Cyclodextrins
A homologous group of cyclic GLUCANS consisting of alpha-1,4 bound glucose units obtained by the action of cyclodextrin glucanotransferase on starch or similar substrates. The enzyme is produced by certain species of Bacillus. Cyclodextrins form inclusion complexes with a wide variety of substances.
alpha-Cyclodextrins
beta-Cyclodextrins
gamma-Cyclodextrins
Rotaxanes
Complex compounds in which a dumbbell shaped molecule is encircled by a macrocycle. They are named after rota (wheel) and axis (axle). Notation with a prefix is used to indicate the number of interlocked components. They have potential use in NANOTECHNOLOGY. Rotaxanes have been made with CYCLODEXTRINS and CYCLIC ETHERS.
Solubility
Starch
Chemistry, Pharmaceutical
Micromonosporaceae
Sun Protection Factor
alpha-Amylases
Glucan 1,4-alpha-Glucosidase
Glucosyltransferases
Acarbose
Interleukin-1beta
Drug Carriers
Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.
Solutions
Hydrophobic and Hydrophilic Interactions
Drug Compounding
Spectrometry, Mass, Fast Atom Bombardment
A mass spectrometric technique that is used for the analysis of a wide range of biomolecules, such as glycoalkaloids, glycoproteins, polysaccharides, and peptides. Positive and negative fast atom bombardment spectra are recorded on a mass spectrometer fitted with an atom gun with xenon as the customary beam. The mass spectra obtained contain molecular weight recognition as well as sequence information.
Calorimetry, Differential Scanning
Magnetic Resonance Spectroscopy
beta 2-Microglobulin
An 11-kDa protein associated with the outer membrane of many cells including lymphocytes. It is the small subunit of the MHC class I molecule. Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. Beta 2-microglobulin is present in small amounts in serum, csf, and urine of normal people, and to a much greater degree in the urine and plasma of patients with tubular proteinemia, renal failure, or kidney transplants.
Bacillus
Models, Molecular
Caesalpinia
A plant genus of the family FABACEAE. The common name of "Bird-Of-Paradise" is also used for other plants such as Heliconia (HELICONIACEAE) and Strelitzia (STRELITZIACEAE) and some birds. The common name of "Cat's-Claw" is more often used with UNCARIA. The common name of "Pernambuco" also refers to a state in Brazil. Furanoditerpenoid lactones and caesalpin are produced by members of this genus.
Galactans
Chewing Gum
beta-Mannosidase
An enzyme that catalyzes the hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides. The enzyme plays a role in the lysosomal degradation of the N-glycosylprotein glycans. Defects in the lysosomal form of the enzyme in humans result in a buildup of mannoside intermediate metabolites and the disease BETA-MANNOSIDOSIS.
Opposite behavior of two isozymes when refolding in the presence of non-ionic detergents. (1/1074)
GroEL has a greater affinity for the mitochondrial isozyme (mAAT) of aspartate aminotransferase than for its cytosolic counterpart (cAAT) (Mattingly JR Jr, Iriarte A, Martinez-Carrion M, 1995, J Biol Chem 270:1138-1148), two proteins that share a high degree of sequence similarity and an almost identical spatial structure. The effect of detergents on the refolding of these large, dimeric isozymes parallels this difference in behavior. The presence of non-ionic detergents such as Triton X-100 or lubrol at concentrations above their critical micelle concentration (CMC) interferes with reactivation of mAAT unfolded in guanidinium chloride but increases the yield of cAAT refolding at low temperatures. The inhibitory effect of detergents on the reactivation of mAAT decreases progressively as the addition of detergents is delayed after starting the refolding reaction. The rate of disappearance of the species with affinity for binding detergents coincides with the slowest of the two rate-limiting steps detected in the refolding pathway of mAAT. Limited proteolysis studies indicate that the overall structure of the detergent-bound mAAT resembles that of the protein in a complex with GroEL. The mAAT folding intermediates trapped in the presence of detergents can resume reactivation either upon dilution of the detergent below its CMC or by adding beta-cyclodextrin. Thus, isolation of otherwise transient productive folding intermediates for further characterization is possible through the use of detergents. (+info)Antilithiasic effect of beta-cyclodextrin in LPN hamster: comparison with cholestyramine. (2/1074)
Beta-Cyclodextrin (BCD), a cyclic oligosaccharide that binds cholesterol and bile acids in vitro, has been previously shown to be an effective plasma cholesterol lowering agent in hamsters and domestic pigs. This study examined the effects of BCD as compared with cholestyramine on cholesterol and bile acid metabolism in the LPN hamster model model for cholesterol gallstones. The incidence of cholesterol gallstones was 65% in LPN hamsters fed the lithogenic diet, but decreased linearly with increasing amounts of BCD in the diet to be nil at a dose of 10% BCD. In gallbladder bile, cholesterol, phospholipid and chenodeoxycholate concentrations, hydrophobic and lithogenic indices were all significantly decreased by 10% BCD. Increases in bile acid synthesis (+110%), sterol 27-hydroxylase activity (+106%), and biliary cholate secretion (+140%) were also observed, whereas the biliary secretion of chenodeoxycholate decreased (-43%). The fecal output of chenodeoxycholate and cholate (plus derivatives) was increased by +147 and +64%, respectively, suggesting that BCD reduced the chenodeoxycholate intestinal absorption preferentially. Dietary cholestyramine decreased biliary bile acid concentration and secretion, but dramatically increased the fecal excretion of chenodeoxycholate and cholate plus their derivatives (+328 and +1940%, respectively). In contrast to BCD, the resin increased the lithogenic index in bile, induced black gallstones in 34% of hamsters, and stimulated markedly the activities of HMG-CoA reductase (+670%), sterol 27-hydroxylase (+310%), and cholesterol 7alpha-hydroxylase (+390%). Thus, beta-cyclodextrin (BCD) prevented cholesterol gallstone formation by decreasing specifically the reabsorption of chenodeoxycholate, stimulating its biosynthesis and favoring its fecal elimination. BCD had a milder effect on lipid metabolism than cholestyramine and does not predispose animals to black gallstones as cholestyramine does in this animal model. (+info)Extraction of cholesterol with methyl-beta-cyclodextrin perturbs formation of clathrin-coated endocytic vesicles. (3/1074)
The importance of cholesterol for endocytosis has been investigated in HEp-2 and other cell lines by using methyl-beta-cyclodextrin (MbetaCD) to selectively extract cholesterol from the plasma membrane. MbetaCD treatment strongly inhibited endocytosis of transferrin and EGF, whereas endocytosis of ricin was less affected. The inhibition of transferrin endocytosis was completely reversible. On removal of MbetaCD it was restored by continued incubation of the cells even in serum-free medium. The recovery in serum-free medium was inhibited by addition of lovastatin, which prevents cholesterol synthesis, but endocytosis recovered when a water-soluble form of cholesterol was added together with lovastatin. Electron microscopical studies of MbetaCD-treated HEp-2 cells revealed that typical invaginated caveolae were no longer present. Moreover, the invagination of clathrin-coated pits was strongly inhibited, resulting in accumulation of shallow coated pits. Quantitative immunogold labeling showed that transferrin receptors were concentrated in coated pits to the same degree (approximately sevenfold) after MbetaCD treatment as in control cells. Our results therefore indicate that although clathrin-independent (and caveolae-independent) endocytosis still operates after removal of cholesterol, cholesterol is essential for the formation of clathrin-coated endocytic vesicles. (+info)Cellular cholesterol regulates expression of the macrophage type B scavenger receptor, CD36. (4/1074)
CD36, the macrophage type B scavenger receptor, binds and internalizes oxidized low density lipoprotein (OxLDL), and may potentially play a role in the development of atherosclerosis. We reported that the native and modified low density lipoproteins increased CD36 mRNA and protein ( J. Biol. Chem. 272: 21654-21659). In this study, we investigated the effect of alterations of cellular cholesterol content on macrophage expression of CD36. Depletion of cholesterol by treatment with beta-cyclodextrins (beta-cyclodextrin [beta-CD] and methylated beta-cyclodextrin [MebetaCD]) significantly decreased CD36 mRNA and 125I-labeled OxLDL binding. Conversely, loading macrophages with cholesterol or cholesteryl ester (acetate) with MebetaCD:cholesterol complexes increased CD36 mRNA, 125I-labeled OxLDL binding, and CD36 surface expression as determined by fluorescence activated cell sorting. Thus, CD36 expression paralleled cellular cholesterol levels after removal of cholesterol with beta-cyclodextrins or addition of cholesterol with MebetaCD:cholesterol complexes. Neither cholesterol depletion nor loading altered expression of type A scavenger receptor mRNA. Kinetics studies showed that changes in CD36 mRNA occurred after changes of cellular cholesterol. Neither beta-cyclodextrins nor MebetaCD:cholesterol altered CD36 mRNA half-life in the presence of actinomycin D, suggesting that alterations in CD36 expression by cholesterol occur at the transcriptional level. These experiments demonstrate that CD36 expression is enhanced by cholesterol and down-regulated by cholesterol efflux, and imply that macrophage expression of CD36 and foam cell formation in atherosclerotic lesions may be perpetuated by a cycle in which lipids drive expression of CD36 in a self-regulatory manner. (+info)Critical role for cholesterol in Lyn-mediated tyrosine phosphorylation of FcepsilonRI and their association with detergent-resistant membranes. (5/1074)
Tyrosine phosphorylation of the high affinity immunoglobulin (Ig)E receptor (FcepsilonRI) by the Src family kinase Lyn is the first known biochemical step that occurs during activation of mast cells and basophils after cross-linking of FcepsilonRI by antigen. The hypothesis that specialized regions in the plasma membrane, enriched in sphingolipids and cholesterol, facilitate the coupling of Lyn and FcepsilonRI was tested by investigating functional and structural effects of cholesterol depletion on Lyn/FcepsilonRI interactions. We find that cholesterol depletion with methyl-beta-cyclodextrin substantially reduces stimulated tyrosine phosphorylation of FcepsilonRI and other proteins while enhancing more downstream events that lead to stimulated exocytosis. In parallel to its inhibition of tyrosine phosphorylation, cholesterol depletion disrupts the interactions of aggregated FcepsilonRI and Lyn on intact cells and also disrupts those interactions with detergent-resistant membranes that are isolated by sucrose gradient ultracentrifugation of lysed cells. Importantly, cholesterol repletion restores receptor phosphorylation together with the structural interactions. These results provide strong evidence that membrane structure, maintained by cholesterol, plays a critical role in the initiation of FcepsilonRI signaling. (+info)Sweet taste responses of mouse chorda tympani neurons: existence of gurmarin-sensitive and -insensitive receptor components. (6/1074)
Inhibitory effects of gurmarin (gur) on responses to sucrose and other sweeteners of single fibers of the chorda tympani nerve in C57BL mice were examined. Of 30 single fibers that strongly responded to 0. 5 M sucrose but were not or to lesser extent responsive to 0.1 M NaCl, 0.01 M HCl, and 0.02 M quinine HCl (sucrose-best fibers), 16 fibers showed large suppression of responses to sucrose and other sweeteners by lingual treatment with 4.8 microM (approximately 20 microg/ml) gur (suppressed to 4-52% of control: gur-sensitive fibers), whereas the remaining 14 fibers showed no such gur inhibition (77-106% of control: gur-insensitive fibers). In gur-sensitive fibers, responses to sucrose inhibited by gur recovered to approximately 70% of control responses after rinsing the tongue with 15 mM beta-cyclodextrin and were almost abolished by further treatment with 2% pronase. In gur-insensitive fibers, sucrose responses were not inhibited by gur, but were largely suppressed by pronase. These results suggest existence of two different receptor components for sweeteners with different susceptibilities to gur in mouse taste cells, one gur sensitive and the other gur insensitive. Taste cells possessing each component may be specifically innervated by a particular type of chorda tympani neurons. (+info)Intracellular phosphotyrosine induction by major histocompatibility complex class II requires co-aggregation with membrane rafts. (7/1074)
Cross-linking MHC class II molecules human leukocyte antigen (HLA-DR) on the surface of THP-1 cells was found to induce their entry into the glycolipid-enriched membrane fraction of the plasma membrane. At the cellular level, this resulted in the synergistic co-aggregation of class II with cholera toxin, a marker of membrane rafts. The accompanying induction of intracellular protein tyrosine phosphorylation could be inhibited by treating cells with methyl-beta-cyclodextrin, a drug that chelates membrane cholesterol and thereby disperses membrane rafts. Signaling could also be inhibited by treating cells with the Src-family kinase inhibitor PP1. Together, these results show that the induced association of class II molecules with membrane rafts can contribute to their aggregation on the cell surface and mediate an association with intracellular protein-tyrosine kinases. (+info)Comparison of the capacity of beta-cyclodextrin derivatives and cyclophanes to shuttle cholesterol between cells and serum lipoproteins. (8/1074)
Previous studies from this laboratory have demonstrated that low concentrations of cyclodextrins (<1.0 mm), when added to serum, act catalytically as cholesterol shuttles to accelerate the exchange of free cholesterol between cells and serum lipoproteins. As cholesterol shuttles, cyclodextrins have the potential to serve as pharmacological agents for modifying cholesterol metabolism. In the present study, we have quantitated the cholesterol-shuttling capacity of a series of newly synthesized beta-cyclodextrin derivatives (betaCDs), with varying structure, and two double-decker cyclophanes. The general protocol is as follows. [(3)H]cholesterol-labeled CHOK1 cells are incubated for 2 h with the test compounds alone or together with 5% human serum, and efflux of the cellular [(3)H]cholesterol is measured. As methyl beta-cyclodextrin (MbetaCD) served as the basis for comparison, initial experiments were conducted that demonstrated there was a dose-dependent stimulation of cell cholesterol efflux as the concentration of MbetaCD increased, with an EC(50) that was calculated to be 0.05 mm. To determine the cholesterol-shuttling capacity of the newly synthesized compounds, cell cholesterol efflux is measured when the compounds are present alone, at a concentration of 0.05 mm, or together with 5% human serum. Our results demonstrate that the double-decker cyclophanes are the most efficient cholesterol shuttles. Under our experimental conditions, methyl beta-cyclodextrin (MbetaCD) approximately doubles the efflux of cell cholesterol to serum, whereas one of the double-decker cyclophanes produces a 4-fold stimulation in efflux. Four of the beta-cyclodextrin derivatives (betaCDs) display shuttling ability similar to that of MbetaCD. Furthermore, there does not appear to be a structural pattern among the other betaCDs which could explain their shuttling capacity. (+info)
Cyclodextrin
GRN 000155, alpha-cyclodextrin;GRAS Notice No. GRN 000074, beta-cyclodextrin;GRAS Notice No. GRN 000046, gamma-cyclodextrin ... beta)-cyclodextrin: 7 glucose subunits γ (gamma)-cyclodextrin: 8 glucose subunits Cyclodextrins are ingredients in more than 30 ... Alpha-, beta-, and gamma-cyclodextrin are all generally recognized as safe by the U.S. FDA. They have been applied for delivery ... Wacker Chemie AG uses dedicated enzymes, that can produce alpha-, beta- or gamma-cyclodextrin specifically. This is very ...
Niemann-Pick disease
"Hydroxypropyl Beta Cyclodextrin for Niemann-Pick Type C1 Disease". ClinicalTrials.gov. NIH. 19 July 2021. Retrieved 10 January ... Researchers at the University of Arizona first proposed the use of 2-hydroxypropyl-β-cyclodextrins for the treatment of Niemann ... "Cyclodextrins in the treatment of a mouse model of Niemann-Pick C disease". Life Sciences. 70 (2): 131-142. doi:10.1016/S0024- ... of Texas Southwestern Medical Center found that when Niemann-Pick type C mice were injected with 2-hydroxypropyl-β-cyclodextrin ...
Decalepis hamiltonii
The active ingredient in the root was synthesized and encapsulated with beta-cyclodextrins. The roots were also subjected to ...
Palmitate mediated localization
Depletion of cholesterol with methyl-beta cyclodextrin disrupts palmitate mediated localization.[citation needed] Levental, I; ...
Α-Cyclodextrin
It is related to the β- (beta) and γ- (gamma) cyclodextrins, which contain seven and eight glucose units, respectively. All ... α-Cyclodextrin (alpha-cyclodextrin), sometimes abbreviated as α-CD, is a hexasaccharide derived from glucose. ... Then cyclodextrin glycosyltransferase (CGTase) is added for enzymatic conversion. CGTases produce diverse cyclodextrins. The ... The exterior surface of cyclodextrins is somewhat hydrophilic whereas the interior core is hydrophobic. α-Cyclodextrin is ...
Supramolecular catalysis
developed a catalyst based on a beta-cyclodextrin carrying two imidazole groups. This cyclodextrin catalytic system mimics ... Cyclodextrins have rigid ring structure, hydrophilic surface, and hydrophobic cavity on the inside; therefore, they are capable ... From the early 1970s, cyclodextrins have been extensively studied for its encapsulation properties and used as binding sites in ... Self-assembled molecules have an advantage over crown ether and cyclodextrin in that they can capture significant larger ...
Chiral analysis
"Separation of drug stereoisomers by the formation of beta-cyclodextrin inclusion complexes". Science. 232 (4754): 1132-1135. ... Cyclodextrins (CDs) are cyclic oligosaccharides of six, seven, or eight glucose units designated as α, β, and γ cyclodextrins ... α-Cyclodextrin holds small aromatic molecules, whereas β-cyclodextrin incorporates both naphthyl groups and substituted phenyl ... Daniel Armstrong is considered the pioneer of micelle and cyclodextrin-based separations. Cyclodextrins are covalently attached ...
Starlicide
Hurley, JC; Volz, SA; Johnston, JJ (1999). "Stabilization of the avicide 3-chloro-p-toluidine as the beta-cyclodextrin adduct ...
Sunscreen
"The Effect of Beta-Cyclodextrin on Percutaneous Absorption of Commonly Used Eusolex® Sunscreens". Drug Research. 63 (11): 591- ... Cyclodextrins have demonstrated the ability to reduce photodecomposition, protect antioxidants and limit skin penetration past ... Yang, Jing; Wiley, Cody J.; Godwin, Donald A.; Felton, Linda A. (June 2008). "Influence of hydroxypropyl-β-cyclodextrin on ... "Sunscreens Containing Cyclodextrin Inclusion Complexes for Enhanced Efficiency: A Strategy for Skin Cancer Prevention". ...
Febreze
The active ingredient in several Febreze products is hydroxypropyl beta-cyclodextrin (HPβCD). The molecule traps and binds ... The use of cyclodextrin as a sprayable odor absorber was patented by Procter & Gamble. The products include additional ... "Chemical Functional Definitions - Cyclodextrin". Procter & Gamble. 2005. Archived from the original on November 10, 2012. *P&G ... Uncomplexed cyclodextrin solutions for odor control on inanimate surfaces. US Pat. No. 5,714,137. Filed 1994; assigned 1998. ...
ARL6IP5
Butchbach ME, Guo H, Lin CL (2003). "Methyl-beta-cyclodextrin but not retinoic acid reduces EAAT3-mediated glutamate uptake and ...
Anthony Czarnik
... beta.-cyclodextrin". Journal of the American Chemical Society. 105 (5): 1390-91. doi:10.1021/ja00343a063. "Anthony W. Czarnik, ...
THC hemisuccinate
... of inclusion complexes of a hemisuccinate ester prodrug of delta9-tetrahydrocannabinol with modified beta-cyclodextrins". AAPS ...
Busulfan
"Synthesis and inclusion ability of a bis-beta-cyclodextrin pseudo-cryptand towards Busulfan anticancer agent". Tetrahedron. 63 ... Porwanski S, Florence DC, Menuel S, Joly JP, Bulach V, Marsura A (2009). "Bis-beta-cyclodextrinyl- and bis-cellobiosyl- ... The molecular recognition of ureido-cyclodextrin with busulfan was investigated. The formation of complexes was observed with ...
Maropitant
Only unbound maropitant causes pain - it is normally formulated with beta-cyclodextrin to increase solubility; at cooler ... temperatures, more of the maropitant remains bound to the cyclodextrin, leaving less maropitant unbound. While there is no pain ...
Saliva testing
... with dimethyl-beta-cyclodextrin". Chem. Pharm. Bull. 45 (2): 378-83. doi:10.1248/cpb.45.378. PMID 9118452. Soell M, Feki A, ...
Medical cannabis
"Sublingual administration of Delta9-tetrahydrocannabinol/beta-cyclodextrin complex increases the bioavailability of Delta9- ...
Avobenzone
Scalia S, Simeoni S, Barbieri A, Sostero S (November 2002). "Influence of hydroxypropyl-beta-cyclodextrin on photo-induced free ... Formulations of avobenzone with hydroxypropyl-beta-cyclodextrin have shown significant reduction in photo-induced degradation, ... Yang J, Wiley C, Godwin D, Felton L (June 2008). "Influence of hydroxypropyl-β-cyclodextrin on transdermal penetration and ... Mangiferin, glutathione, ubiquinone, vitamin C, vitamin E, beta-carotene and trans-resveratrol have all demonstrated some ...
Silibinin
Due to its immunomodulatory, iron chelating and antioxidant properties, this herb has the potential to be used in beta- ... It has been also reported that silymarin inclusion complex with β-cyclodextrin is much more soluble than silymarin itself. ... "Solid state mechanochemical activation of Silybum marianum dry extract with betacyclodextrins: Characterization and ...
Niemann-Pick disease, type C
... the FDA granted Hydroxypropyl-beta-cyclodextrin orphan drug status and designated HPbCD cyclodextrin as a potential treatment ... In April 2009, hydroxypropyl-beta-cyclodextrin (HPbCD) was approved under compassionate use by the U.S. Food and Drug ... Ward S, O'Donnell P, Fernandez S, Vite CH (July 2010). "2-hydroxypropyl-beta-cyclodextrin raises hearing threshold in normal ... cyclodextrin therapy. On January 23, 2013, a formal clinical trial to evaluate HPβCD cyclodextrin therapy as a treatment for ...
Catechin
... catechin by beta-cyclodextrin by a combination of NMR, microcalorimetry and molecular modeling techniques". Organic & ... Epigeoside (Catechin-3-O-alpha-L-rhamnopyranosyl-(1-4)-beta-D-glucopyranosyl-(1-6)-beta-D-glucopyranoside) can be isolated from ...
Transfection
... beta-cyclodextrin) dendrimeric tetrapod as a potential gene delivery (DNA and siRNA) system. Study of cellular siRNA ... Chemical-based transfection can be divided into several kinds: cyclodextrin, polymers, liposomes, or nanoparticles (with or ...
1,4-Butane sultone
Derived from this the derivatization of β-cyclodextrin to sulfobutyl ether-beta-cyclodextrin (SBECD) is by now an important ... Sulfobutyl ether-beta-cyclodextrin is a water-soluble inclusion compound for the solubilization and stabilization of sparsely ... Sulfobutyl ether-beta-cyclodextrin also finds a wide range of applications as an inert vehicle for drug delivery (the drugs ... "Evaluation of a sulfobutyl ether beta-cyclodextrin as a solubilizing/stabilizing agent for several drugs", Drug Dev. Ind. Pharm ...
Toll-like receptor 7
... as well as the delivery of resiquimod via nanoparticles formed from beta-cyclodextrin. In July 2020, it was discovered that a ...
Hemolysin
At the moment, apiegnin and beta-cyclodextrin are thought to alleviate S.aureus pneumonia, whereas the antibodies of anti alpha ... Maheswaran SK, Lindorfer RK (November 1967). "Staphylococcal beta-hemolysin. II. Phospholipase C activity of purified beta- ... Compared to beta-hemolysin, it has a higher affinity for phosphocholines with short saturated acyl chains, especially if they ...
Madeleine M. Joullié
Beta-cyclodextrin sulfate is also useful in limiting restenosis, growth of cells on artery walls that can lead to blockages at ... Joullié helped to synthesize beta-cyclodextrin sulfate, a ring-shaped sugar molecule that attaches to the walls of growing ...
Glycoside hydrolase family 14
The 3D structure of a complex of soybean beta-amylase with an inhibitor (alpha-cyclodextrin) has been determined to 3.0A ... while the smaller is formed from two long loops extending from the beta-3 and beta-4 strands of the (beta alpha)8 fold. The ... Beta-amylase is present in certain bacteria as well as in plants. Three highly conserved sequence regions are found in all ... Beta-amylase is an enzyme that hydrolyzes 1,4-alpha-glucosidic linkages in starch-type polysaccharide substrates so as to ...
List of MeSH codes (D09)
... cyclodextrins MeSH D09.698.365.855.400.375.222 - alpha-cyclodextrins MeSH D09.698.365.855.400.375.333 - beta-cyclodextrins MeSH ... beta-glucans MeSH D09.698.365.089.500 - lentinan MeSH D09.698.365.089.625 - sizofiran MeSH D09.698.365.089.750 - zymosan MeSH ... D09.698.365.855.400.375.444 - gamma-cyclodextrins MeSH D09.698.365.855.500 - hetastarch MeSH D09.698.365.855.750 - inulin MeSH ...
List of MeSH codes (D04)
MeSH D04.345.051.500 - crown ethers MeSH D04.345.103.222 - alpha-cyclodextrins MeSH D04.345.103.333 - beta-cyclodextrins MeSH ... D04.345.103.444 - gamma-cyclodextrins MeSH D04.345.241.308 - crown ethers MeSH D04.345.295.500 - maytansine MeSH D04.345. ...
CRLX101
... which in turn consists of alternating subunits of beta-cyclodextrin and polyethylene glycol (PEG). The CRLX101 nanoparticle is ... The agent represents a nanoparticle conjugate that consists of a drug delivery molecule, namely a cyclodextrin-based polymer ( ... a cyclodextrin-containing polymer-camptothecin nanopharmaceutical in patients with advanced solid tumor malignancies". Invest. ...
List of food additives
... artificial sweetener beta-cyclodextrin - emulsifier Lemongrass (Cymbopogon citratus, C. flexuosus, and other species) - Damiana ... in Earl Grey tea Beta-apo-8'-carotenal (C 30) - color Beta-apo-8'-carotenic acid ethyl ester - color Betanin - color (red) ... Carotenes - color Alpha-carotene - color Beta-carotene - color Gamma-carotene - color Carrageenan - thickener, vegetable gum, ...
List of chemical compounds with unusual names
Apropos of the study of the hemostatic activity in prostatectomy of a new molecule: beta-naphthoquinone monosemicarbazone ( ... Complexes and Their Supramolecular Assemblies with β-Cyclodextrin". Inorg Chem. 43 (11): 3521-3527. doi:10.1021/ic0352250. PMID ...
Host-guest chemistry
... beta _{pq}} , is defined as β p q = [ H p G q ] [ H ] p [ G ] q {\displaystyle \beta _{pq}={\frac {[H_{p}G_{q}]}{[H]^{p}[G]^{q ... and Molecular Dynamics of Cyclodextrins with a Non-ionic Surfactant". Journal of Physical Chemistry B. 111 (17): 4383-92. doi: ... T H = [ H ] + ∑ p β p q [ H ] p [ G ] q {\displaystyle T_{H}=[H]+\sum p\beta _{pq}[H]^{p}[G]^{q}} T G = [ G ] + ∑ q β p q [ H ... beta _{pq}[H]^{p}[G]^{q}} . The relationship between a species' concentration and the measured quantity is specific for the ...
Glycogen branching enzyme
... cyclodextrin glucanotransferase (CGT), and branching enzyme. Shown by x-ray crystallography, glycogen branching enzyme has four ... insights of N-terminal beta-sandwich in substrate specificity and enzymatic activity". The Journal of Biological Chemistry. 285 ...
Wolfram Saenger
Water Molecule in Hydrophobic Surroundings: Structure of alpha-Cyclodextrin-Hexahydrate (C6H10O5)6·6H2O, Nature, 1972 Circular ... Nature 1993 Crystal structure of beta-D-cellotetraose hemihydrate with implications for the structure of cellulose II, Science ...
Metal-organic framework
Jambhekar SS, Breen P (February 2016). "Cyclodextrins in pharmaceutical formulations I: structure and physicochemical ... Highly enantioselective Ru catalysts for asymmetric hydrogenation of beta-aryl ketoesters and their immobilization in room- ...
Imatinib
It is not known whether reduction of beta-amyloid is a feasible way of treating Alzheimer's, as an anti-beta-amyloid vaccine ... A formulation of imatinib with a cyclodextrin (Captisol) as a carrier to overcome the blood-brain barrier has shown reversal of ... In July 1997, Novartis filed a new patent application in Switzerland on the beta crystalline form of imatinib mesylate (the ... The solid form of imatinib mesylate in Gleevec is beta crystalline. As provided under the TRIPS agreement, Novartis applied for ...
Dextrin
Cyclodextrin The cyclical dextrins are known as cyclodextrins. They are formed by enzymatic degradation of starch by certain ... Beta) Limit dextrin is the remaining polymer produced by enzymatic hydrolysis of amylopectin with beta amylase, which cannot ... bacteria, for example, Paenibacillus macerans (Bacillus macerans). Cyclodextrins have toroidal structures formed by 6-8 glucose ...
Natural product
Penicillin and related beta lactams work by inhibiting DD-transpeptidase enzyme that is required by bacteria to cross link ... Examples of enzymes identified to date include amylases, pullulanases, cyclodextrin glycosyltransferases, cellulases, xylanases ...
Neopullulanase
... also known as an alpha/beta barrel), an alpha/beta protein fold structure consisting of eight parallel beta-strands connected ... "Complex structures of Thermoactinomyces vulgaris R-47 alpha-amylase 2 with acarbose and cyclodextrins demonstrate the multiple ... beta-amylase, and alpha-D-glucosidase) and only achieves a 40% yield of isomaltooligosaccharides from starch. When immobilized ...
Transporter Classification Database
... family 1.B.66 Putative beta-barrel porin-2 (BBP2) family 1.B.67 Putative beta barrel porin-4 (BBP4) family 1.B.68 Putative beta ... family 1.B.26 Cyclodextrin porin (CDP) family 1.B.31 Campylobacter jejuni major outer membrane porin (MomP) family 1.B.32 ...
Cyclomaltodextrin glucanotransferase
... alpha-cyclodextrin glucanotransferase, alpha-cyclodextrin glycosyltransferase, beta-cyclodextrin glucanotransferase, beta- ... cyclodextrin glycosyltransferase, gamma-cyclodextrin glycosyltransferase, cyclodextrin glycosyltransferase, cyclomaltodextrin ... "Rational design of cyclodextrin glycosyltransferase from Bacillus circulans strain 251 to increase alpha-cyclodextrin ... The coupling reaction can be easily described as the reverse process of cyclization: the enzyme cleaves a cyclodextrin to ...
Carbohydrate-binding module
It has a beta-jelly roll fold, with a groove on the concave surface of one of the beta-sheets. Carbohydrate-binding module ... "The raw starch binding domain of cyclodextrin glycosyltransferase from Bacillus circulans strain 251". The Journal of ... CBM27 adopts a beta sandwich structure comprising 13 beta strands with a single, small alpha-helix and a single metal atom. ... It has a budded fibronectin type III fold consisting of two beta-sheets, arranged as a beta-sheet sandwich and a bud consisting ...
Lobaria pulmonaria
... beta carotene, and beta cryptoxanthin. The upper cortex of the lichen contains melanins that screen UV and PAR radiation from ... when the spores are grown in a synthetic growth medium containing an adsorbent like bovine serum albumin or α-cyclodextrin. ...
Sustainable business
Stoddart, Sir Fraser (2013). "Selective isolation of gold facilitated by second-sphere coordination by α-cyclodextrin". Nature ... MIT TechTV beta, 55 min., 51 sec. Galvao, A. "Mind Your Own Business, Why sustainable operations must be everyone's chief ...
Camptothecin
The beta-subunit of tryptophan synthase (TSB) catalyzes condensation of indole with serine, leading to tryptophan. In the next ... CPT is linked to a cyclodextrin-based polymer to form the investigational anti-cancer drug CRLX101. Like all other ...
Beta-cyclodextrin (CD) inclusion complexes of disconnected synthetic cannabinoid molecules - The Lincoln Repository
2017) Beta-cyclodextrin (CD) inclusion complexes of disconnected synthetic cannabinoid molecules. In: CHM3006M [Conference], 24 ... Beta-cyclodextrin (CD) Inclusion Complexes of Disconnected Synthetic Cannabinoid Molecules_UoL.pdf 708kB. ... Beta-cyclodextrin (CD) Inclusion Complexes of Disconnected Synthetic Cannabinoid Molecules_UoL.pdf. ... synthetic cannabinoid, cyclodextrin, SERS. Subjects:. F Physical Sciences , F100 Chemistry. F Physical Sciences , F410 Forensic ...
Peroxygens - Product catalog | Solvay
Removal of copper ions from water using epichlorohydrin cross-linked beta-cyclodextrin polymer: characterization, isotherms and...
Beta-cyclodextrin (beta-CD) cross-linked with epichlorohydrin to form water insoluble beta-cyclodextrin polymer (beta-CDP) has ... Removal of copper ions from water using epichlorohydrin cross-linked beta-cyclodextrin polymer: characterization, isotherms and ... The objective of this study was to explore the sorption mechanism of beta-CDP for copper. The effects of different experimental ... Hence, the adsorption-desorption trends of epichlorohydrin cross-linked with beta-CD, along with its good recyclability, ...
Take drug additive, not drug? | The Scientist Magazine®
Researchers at the University of Texas Southwestern Medical School in Dallas fed NPC mice a form of cyclodextrin, a doughnut- ... Chemical structure of beta-cyclodextrin "There are major biochemical shifts, very suddenly," Dietschy told... ... Researchers at the University of Texas Southwestern Medical School in Dallas fed NPC mice a form of cyclodextrin, a doughnut- ... Researchers at the University of Texas Southwestern Medical School in Dallas fed NPC mice a form of cyclodextrin, a doughnut- ...
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Prof Angela Danil de Namor | University of Surrey
Copolymers Based on Butyl Methacrylate and beta-cyclodextrin: Synthesis and Structure. S.V.Riabov, V.I.Shtompel, A,F.Maslyuk,Yu ... Peculiarities of interaction of silica with tosyl-b-cyclodextrins. A.Belyakova, D.Yu.Lyashenko, A.M.Varvarin, S.V.Ryabov, Yu.Yu ... Thermodynamic and kinetic studies are undertaken in order to assess the effect of cyclodextrin on the transfer of drugs from ... 2. The Effect of Cyclodextrins on the Transfer of Drugs and other Guests from Water to Non-Aqueous Solvents Particular ...
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This Cheap Sugar-Based Filter Could Help Clean Up Toxic Waterways : ScienceAlert
Beta-cyclodextrin is a naturally occurring bio-renewable sugar molecule derived from cornstarch. The cyclodextrin is ... As the name suggests, cyclodextrins are made up of sugar molecules bound together in a ring. The ring-like nature of beta- ... Even very small amounts of the beta-cyclodextrin polymer can reduce the levels of PFOA to below the environmental protection ... Scientists have created a new polymer material constructed from a simple sugar molecule, beta-cyclodextrin. The material is ten ...
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Polymerized cyclomaltoheptaose (beta-cyclodextrin, beta-CDn) inclusion complex formation with chlorogenic acid: solvent effects ... Medicamentos para el asma (agonistas beta-adrenérgicos). El café verde contiene cafeína. La cafeína puede estimular el corazón ... van Dam, R. M. Coffee and type 2 diabetes: from beans to beta-cells. Nutr Metab Cardiovasc.Dis. 2006;16:69-77. View abstract. ... Caffeine-induced impairment of glucose tolerance is abolished by beta-adrenergic receptor blockade in humans. J Appl Physiol . ...
Biosynthesis of Silver Nanoparticles from Rhododendron arboreum for Metal Sensing, Antibacterial Assessment, and Photocatalytic...
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National Institues of Health Announces Cyclodextrin Clincial Trial For Fatal Cholesterol Disease Called Niemann Pick Type C |...
Caroline Hastings and I regarding Addi and Cassis treatments with hydroxypropyl-beta-cyclodextrin. Since sharing our ... intravenous (IV) and intrathecal (IT) cyclodextrin treatment protocols with NPC families and doctors in the U.S. and other ... Tags: 2-Hydroxypropyl-beta-Cyclodextrin, Cholesterol, Cyclodextrin, Dr. Caroline Hastings, Dr. Forbes "Denny" Porter, FDA, ... HPBCD, intracerebroventricular cyclodextrin, intrathecal cyclodextrin, intravenous cyclodextrin, Medtronic SynchroMed pump, ...
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beta-Cyclodextrins - Preferred Concept UI. M0457481. Scope note. Cyclic GLUCANS consisting of seven (7) glucopyranose units ... ciclodextrinas beta Scope note:. GLUCANOS cíclicos que constan de 7 unidades glucopiranosa unidas por enlaces 1,4-glicosídicos. ... 2-Hydroxypropyl-beta-cyclodextrin [D09.698.365.855.400.375.333.500] 2-Hydroxypropyl-beta-cyclodextrin ... 2-Hydroxypropyl-beta-cyclodextrin [D09.301.915.400.375.333.500] 2-Hydroxypropyl-beta-cyclodextrin ...
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Annual severity increment score as a tool for stratifying patients with Niemann-Pick disease type C and for recruitment to...
... intrathecal cyclodextrin (VTS-270 2, hydroxypropyl-beta-cyclodextrin) [8], intravenous cyclodextrin (TrapsolCyclo®) and the ... b Arimoclomol trial ages 2-18 and c 2-Hydroxy-beta-cyclodextrin ages 4-21. The plots depict the study cohort with these ... Chronic cyclodextrin treatment of murine Niemann-pick C disease ameliorates neuronal cholesterol and glycosphingolipid storage ... arimoclomol and intra-thecal 2-hydroxypropyl-β-cyclodextrin). All three studies rely on patient age as a primary inclusion ...
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Environmentally compatible synthesis of superparamagnetic magnetite (Fe3O4) nanoparticles with prehydrolysate from corn stover...
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Find Research outputs - Manipal Academy of Higher Education, Manipal, India
Remdesivir for Covid-19: Dosages, Warnings, Adverse Effects - The Kent Center
Search | SciELO
On this context it has been considered the use of cyclodextrin derivatives like hydroxypropyl-beta-cyclodextrin as an ... Hydroxypropyl-beta-cyclodextrin grants better solubility characteristics to included drugs. Indomethacins complexation ... With this review we intend to evaluate the rational for using indomethacins complexation with hydroxypropyl-beta-cyclodextrin ... Complexos de inclusão de indometacina com hidroxipropil-beta-ciclodextrina: estudos de dissolução e coeficiente de partição ...
Cyclodextrin in Pharma Market Share, Analysis | Global Report, 2030
The global market size, share, along with dynamics are covered in the cyclodextrin in pharma market report ... Cyclodextrin in Pharma Market is anticipated to reach USD XX.X MN by 2028, this market report provides the growth, trends, ... Alpha-cyclodextrin, beta-cyclodextrin, and gamma-cyclodextrin are the three kinds of cyclodextrin. Beta-cyclodextrin is a ... Furthermore, hydroxypropyl-ß-cyclodextrins, nonionic cyclodextrins, mono-6-(fmoc-gln-otbu) cyclodextrin, methyl-cyclodextrin ( ...
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CYTH - Stock Quotes for Cyclo Therapeutics Inc - Webull
The Companys lead drug candidate, Trappsol Cyclo (hydroxypropyl beta cyclodextrin) is a treatment for Niemann-Pick Type C ... It is also focusing on the use of cyclodextrins in the treatment of Alzheimers disease. Its product lines include Trappsol and ... is a clinical stage biotechnology company that develops cyclodextrin-based products for the treatment of disease. ... The Company also sells cyclodextrins and related products to the pharmaceutical, nutritional, and other industries, primarily ...
HPBCD5
- Hydroxypropyl beta cyclodextrin (HPBCD) is being tested for a disease called Niemann-Pick disease type C1 (NPC1). (nih.gov)
- Last year, after Dr. Caroline Hastings and I received the U.S. Food and Drug Administration orphan drug designation for Hydroxy-propyl-beta-cyclodextrin (HPBCD) for the treatment of Niemann Pick Type C disease, I was contacted by Sue French. (addiandcassi.com)
- They do not understand that some cyclodextrins (like HPBCD) have been discovered to be active pharmaceutical ingredients (APIs) and have massive effects when they interact with cholesterol in the human body. (addiandcassi.com)
- The hydroxypropyl-beta cyclodextrin (HPbCD) has been approved for pharmaceutical use. (nih.gov)
- Recent reports show that beta-cyclodextrin including HPbCD and beta-methyl-cyclodextrin reduced cholesterol accumulation and neuronal cell loss in the mouse model of NPC1 disease. (nih.gov)
Hydroxypropyl10
- PAH bioavailability was altered by the addition of two biosurfactants, rhamnolipid and hydroxypropyl-beta-cyclodextrin (HPCD). (nih.gov)
- 6. Preparation and characterization of simvastatin/hydroxypropyl-beta-cyclodextrin inclusion complex using supercritical antisolvent (SAS) process. (nih.gov)
- 8. Investigation of inclusion complex of cilnidipine with hydroxypropyl-β-cyclodextrin. (nih.gov)
- 9. The influence of hydroxypropyl-β-cyclodextrin on the solubility, dissolution, cytotoxicity, and binding of riluzole with human serum albumin. (nih.gov)
- 10. Curve-fitting FTIR studies of loratadine/hydroxypropyl-beta-cyclodextrin inclusion complex induced by co-grinding process. (nih.gov)
- 11. Inclusion complex of barbigerone with hydroxypropyl-β-cyclodextrin: preparation and in vitro evaluation. (nih.gov)
- 16. Molecular simulation of hydroxypropyl-beta-cyclodextrin with hydrophobic selective Cox-II chemopreventive agent using host-guest phenomena. (nih.gov)
- 17. Physicochemical characteristics and oral bioavailability of andrographolide complexed with hydroxypropyl-beta-cyclodextrin. (nih.gov)
- The drug, 2-hydroxypropyl-beta-cyclodextrin (VTS-270), is being tested under a cooperative research and development agreement , or CRADA, between NIH and Sucampo Pharmaceuticals, Inc . In April 2017, Sucampo acquired Vtesse Inc., which previously had been developing VTS-270. (nih.gov)
- Note that Phosphatidylcholine 75% and Hydroxypropyl Beta Cyclodextrin (HPβCD) are the Cyclosome delivery system additives but do not steal from the active ingredient weight! (priceplow.com)
Molecules3
- The cyclodextrin is transformed into a polymer by connecting the molecules together with another molecule - known as cross linking. (sciencealert.com)
- As the name suggests, cyclodextrins are made up of sugar molecules bound together in a ring. (sciencealert.com)
- The ring-like nature of beta-cyclodextrin creates a molecular bucket that's the perfect size for capturing and holding on to the PFOA molecules. (sciencealert.com)
Polymer4
- Removal of copper ions from water using epichlorohydrin cross-linked beta-cyclodextrin polymer: characterization, isotherms and kinetics. (bvsalud.org)
- Beta- cyclodextrin (beta-CD) cross-linked with epichlorohydrin to form water insoluble beta- cyclodextrin polymer (beta- CDP ) has been shown to be an effective sorbent for sorption of organic particles , but the sorption of copper (Cu2+) in aqueous solutions by beta- CDP has not been conducted. (bvsalud.org)
- Scientists have created a new polymer material constructed from a simple sugar molecule, beta-cyclodextrin. (sciencealert.com)
- Even very small amounts of the beta-cyclodextrin polymer can reduce the levels of PFOA to below the environmental protection agency's advised limit of 70 parts per trillion, which is equal to one teaspoon of PFOA in 14 Olympic-sized swimming pools. (sciencealert.com)
Derivative2
Gamma3
- The alpha-CD (6 sugars), beta-CD (7 sugars) and gamma-CD (8 sugars) are commonly used cyclodextrins. (nih.gov)
- NCATS investigators found that CD (alpha-, beta- and gamma-CDs) increased intracellular Ca2+ and lysosomal exocytosis in both wild type cells and cells with Wolman disease, and reduced the size of enlarged lysosomes in six patient cell lines with LSDs. (nih.gov)
- Based on these results, they propose treatment of LSDs with cyclodextrins (such as alpha and gamma forms) alone or in combination with Vitamin E and its analogues for better efficacy and less side effects. (nih.gov)
Clinical trials1
- Sue and I are now back to working from our homes to move cyclodextrin clinical trials forward to prove it works in people. (addiandcassi.com)
Inclusion5
- EURECO™ HC P11 is a powdered inclusion complex of pharma-grade beta-cyclodextrin and PAP (6-phthalimido-peroxy-hexanoic acid). (solvay.com)
- 4. The effect of mechanical grinding on the formation, crystalline changes and dissolution behaviour of the inclusion complex of telmisartan and β-cyclodextrins. (nih.gov)
- 13. Preparation, characterisation and antitumour activity of β-, γ- and HP-β-cyclodextrin inclusion complexes of oxaliplatin. (nih.gov)
- 15. Inclusion complexes of tadalafil with natural and chemically modified beta-cyclodextrins. (nih.gov)
- 19. Non-inclusion complexes between riboflavin and cyclodextrins. (nih.gov)
Cholesterol2
- When the researchers, led by linkurl:John Dietschy,;http://www.utsouthwestern.edu/findfac/professional/0,,11822,00.html administered one dose of cyclodextrin to young NPC mice, the amount of accumulated cholesterol in cells decreased markedly, liver function and neural function improved, and the mice lived longer than untreated NPC mice. (the-scientist.com)
- Cyclodextrins (CD), alone or in combination with other agents (e.g., vitamin E), as therapeutics for the treatment of lysosomal storage disorders (LSDs) caused by the accumulation of non-cholesterol lipids. (nih.gov)
NPC11
- 5. Patients who have received any form of cyclodextrin in an attempt to treat NPC1. (nih.gov)
Form1
- Researchers at the University of Texas Southwestern Medical School in Dallas fed NPC mice a form of cyclodextrin, a doughnut-shaped chemical with a water-soluble ring and a fat-soluble hole that enables the compound to solubilize an otherwise insoluble molecule, such as a drug. (the-scientist.com)
Disease1
- After holding one final conference call with the EMA staff, Sue raced off to meet the deadline and submit all the documents and medical rational for cyclodextrin as a treatment for Niemann Pick Type C disease. (addiandcassi.com)
Drug4
- Treatment with another drug preparation for another medical indication that contains cyclodextrin as an excipient, will not exclude a patient. (nih.gov)
- 2. Amorphous ternary cyclodextrin nanocomposites of telmisartan for oral drug delivery: improved solubility and reduced pharmacokinetic variability. (nih.gov)
- Sue and I decided that in order to further legitimize cyclodextrin as a potentially lifesaving therapy throughout the EU for Niemann Pick Type C patients, we needed to work together to pursue an orphan drug designation from the EMA. (addiandcassi.com)
- In June 2011, we received a positive opinion from the Committee for Orphan Medicinal Products (COMP) for Hydroxy-propyl-beta-cyclodextrin for the treatment of Niemann Pick Type C. Seven other pharmaceutical companies seeking orphan drug designations for different products (including Novartis and Pfizer) were also listed along with us - not too shabby! (addiandcassi.com)
Patients1
- Sue and I discussed her interest in seeking compassionate use of Hydroxy-propyl-beta-cyclodextrin in the UK to treat patients like her son. (addiandcassi.com)
Activity1
- Benzoic acid (BA) and sorbic acid (SA) were incorporated to beta CD-TiO2 NPs and the antibacterial activity of PLA and CA composite films was studied by inactivation of Escherichia coli and Staphylococcus aureus. (unav.edu)
Hydroxypropyl-beta-cyclodextrin9
- 2-Hydroxypropyl-beta-cyclodextrin (HPβCD) has gained recent attention as a potential therapeutic intervention in the treatment of the rare autosomal-recessive, neurodegenerative lysosomal storage disorder Niemann-Pick Disease Type C1 (NPC1). (nih.gov)
- PAH bioavailability was altered by the addition of two biosurfactants, rhamnolipid and hydroxypropyl-beta-cyclodextrin (HPCD). (nih.gov)
- Hydroxypropyl beta cyclodextrin (HPBCD) is being tested for a disease called Niemann-Pick disease type C1 (NPC1). (nih.gov)
- 3. Improvement of solubility and oral bioavailability of 2-(N-cyanoimino)-5-[(E)-4-styrylbenzylidene]-4-oxothiazolidine (FPFS-410) with antidiabetic and lipid-lowering activities in dogs by 2-hydroxypropyl-beta-cyclodextrin. (nih.gov)
- 8. Characterization of the complexes of furosemide with 2-hydroxypropyl-beta-cyclodextrin and sulfobutyl ether-7-beta-cyclodextrin. (nih.gov)
- 19. UV-vis and FTIR-ATR characterization of 9-fluorenon-2-carboxyester/(2-hydroxypropyl)-beta-cyclodextrin inclusion complex. (nih.gov)
- The drug, 2-hydroxypropyl-beta-cyclodextrin (VTS-270), is being tested under a cooperative research and development agreement , or CRADA, between NIH and Sucampo Pharmaceuticals, Inc . In April 2017, Sucampo acquired Vtesse Inc., which previously had been developing VTS-270. (nih.gov)
- The hydroxypropyl-beta cyclodextrin (HPbCD) has been approved for pharmaceutical use. (nih.gov)
- Hoa is the consulting otologist on the protocol Hydroxypropyl Beta Cyclodextrin for Niemann-Pick Type C1 Disease which is sponsored by a Mallinckrodt Pharmaceuticals, and is being conducted by the NIH Eunice Kennedy Shriver National Institute of Child Health and Human Development and the NIH National Center for Advancing Translational Sciences with Dr. Forbes D. Porter serving. (nih.gov)
Excipient1
- Treatment with another drug preparation for another medical indication that contains cyclodextrin as an excipient, will not exclude a patient. (nih.gov)
Sodium1
- Accumulation of the solvent vehicle sulphobutylether beta cyclodextrin sodium in critically ill patients treated with intravenous voriconazole under renal replacement therapy. (medscape.com)
Characterization3
- 16. Novel inclusion complex of ibuprofen tromethamine with cyclodextrins: physico-chemical characterization. (nih.gov)
- 17. Physicochemical and structural characterization of quercetin-beta-cyclodextrin complexes. (nih.gov)
- 18. Diloxanide furoate binary complexes with β-, methyl-β-, and hydroxypropyl-β-cyclodextrins: inclusion mode, characterization in solution and in solid state and in vitro dissolution studies. (nih.gov)
Formulation2
Accumulation1
- Cyclodextrins (CD), alone or in combination with other agents (e.g., vitamin E), as therapeutics for the treatment of lysosomal storage disorders (LSDs) caused by the accumulation of non-cholesterol lipids. (nih.gov)
Binary1
- Tailored beta-cyclodextrin blocks the translocation pores of binary exotoxins from Clostridium botulinum and Clostridium perfringens and protects mammalian cells from intoxication. (nih.gov)
Pharmaceutical1
- 5. Improvement of some pharmaceutical properties of DY-9760e by sulfobutyl ether beta-cyclodextrin. (nih.gov)
Complex2
- Notably, HPβCD formulations are not comprised of a single molecular species, but instead are complex mixtures of species with differing degrees of hydroxypropylation of the cyclodextrin ring. (nih.gov)
- 10. Water-soluble Complex of Curcumin with Cyclodextrins: Enhanced Physical Properties For Ocular Drug Delivery. (nih.gov)
Treatment1
- Based on these results, they propose treatment of LSDs with cyclodextrins (such as alpha and gamma forms) alone or in combination with Vitamin E and its analogues for better efficacy and less side effects. (nih.gov)
Effects1
- 7. Stabilizing and solubilizing effects of sulfobutyl ether beta-cyclodextrin on prostaglandin E1 analogue. (nih.gov)
Solution2
- 12. Effect of cyclodextrins on the solubility and stability of candesartan cilexetil in solution and solid state. (nih.gov)
- 15. Solubility and mass and nuclear magnetic resonance spectroscopic studies on interaction of cyclosporin A with dimethyl-alpha- and -beta-cyclodextrins in aqueous solution. (nih.gov)
