Cyclodextrins: A homologous group of cyclic GLUCANS consisting of alpha-1,4 bound glucose units obtained by the action of cyclodextrin glucanotransferase on starch or similar substrates. The enzyme is produced by certain species of Bacillus. Cyclodextrins form inclusion complexes with a wide variety of substances.alpha-Cyclodextrins: Cyclic GLUCANS consisting of six (6) glucopyranose units linked by 1,4-glycosidic bonds.beta-Cyclodextrins: Cyclic GLUCANS consisting of seven (7) glucopyranose units linked by 1,4-glycosidic bonds.gamma-Cyclodextrins: Cyclic GLUCANS consisting of eight (8) glucopyranose units linked by 1,4-glycosidic bonds.DextrinsTrimeprazine: A phenothiazine derivative that is used as an antipruritic.Rotaxanes: Complex compounds in which a dumbbell shaped molecule is encircled by a macrocycle. They are named after rota (wheel) and axis (axle). Notation with a prefix is used to indicate the number of interlocked components. They have potential use in NANOTECHNOLOGY. Rotaxanes have been made with CYCLODEXTRINS and CYCLIC ETHERS.Solubility: The ability of a substance to be dissolved, i.e. to form a solution with another substance. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Starch: Any of a group of polysaccharides of the general formula (C6-H10-O5)n, composed of a long-chain polymer of glucose in the form of amylose and amylopectin. It is the chief storage form of energy reserve (carbohydrates) in plants.Chemistry, Pharmaceutical: Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use.Micromonosporaceae: A family of gram-positive, saprophytic bacteria occurring in soil and aquatic environments.Optical Rotation: The rotation of linearly polarized light as it passes through various media.Sun Protection Factor: A measure of relative protection provided by SUNSCREENING AGENTS against burns due to ultraviolet (UV) radiation from a light source.alpha-Amylases: Enzymes that catalyze the endohydrolysis of 1,4-alpha-glycosidic linkages in STARCH; GLYCOGEN; and related POLYSACCHARIDES and OLIGOSACCHARIDES containing 3 or more 1,4-alpha-linked D-glucose units.Myristates: Salts and esters of the 14-carbon saturated monocarboxylic acid--myristic acid.Glucan 1,4-alpha-Glucosidase: An enzyme that catalyzes the hydrolysis of terminal 1,4-linked alpha-D-glucose residues successively from non-reducing ends of polysaccharide chains with the release of beta-glucose. It is also able to hydrolyze 1,6-alpha-glucosidic bonds when the next bond in sequence is 1,4.Drug Stability: The chemical and physical integrity of a pharmaceutical product.Glucosyltransferases: Enzymes that catalyze the transfer of glucose from a nucleoside diphosphate glucose to an acceptor molecule which is frequently another carbohydrate. EC 2.4.1.-.Acarbose: An inhibitor of ALPHA-GLUCOSIDASES that retards the digestion and absorption of DIETARY CARBOHYDRATES in the SMALL INTESTINE.Interleukin-1beta: An interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein. Proteolytic processing of the precursor form by CASPASE 1 results in release of the active form of interleukin-1beta from the membrane.Drug Carriers: Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.Glycoside HydrolasesSolutions: The homogeneous mixtures formed by the mixing of a solid, liquid, or gaseous substance (solute) with a liquid (the solvent), from which the dissolved substances can be recovered by physical processes. (From Grant & Hackh's Chemical Dictionary, 5th ed)Hydrophobic and Hydrophilic Interactions: The thermodynamic interaction between a substance and WATER.Drug Compounding: The preparation, mixing, and assembling of a drug. (From Remington, The Science and Practice of Pharmacy, 19th ed, p1814)Spectrometry, Mass, Fast Atom Bombardment: A mass spectrometric technique that is used for the analysis of a wide range of biomolecules, such as glycoalkaloids, glycoproteins, polysaccharides, and peptides. Positive and negative fast atom bombardment spectra are recorded on a mass spectrometer fitted with an atom gun with xenon as the customary beam. The mass spectra obtained contain molecular weight recognition as well as sequence information.Calorimetry, Differential Scanning: Differential thermal analysis in which the sample compartment of the apparatus is a differential calorimeter, allowing an exact measure of the heat of transition independent of the specific heat, thermal conductivity, and other variables of the sample.Magnetic Resonance Spectroscopy: Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).beta 2-Microglobulin: An 11-kDa protein associated with the outer membrane of many cells including lymphocytes. It is the small subunit of the MHC class I molecule. Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. Beta 2-microglobulin is present in small amounts in serum, csf, and urine of normal people, and to a much greater degree in the urine and plasma of patients with tubular proteinemia, renal failure, or kidney transplants.Bacillus: A genus of BACILLACEAE that are spore-forming, rod-shaped cells. Most species are saprophytic soil forms with only a few species being pathogenic.Models, Molecular: Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.Hospital Auxiliaries: Volunteer organizations whose members perform work for the hospital without compensation.Dental Auxiliaries: Personnel whose work is prescribed and supervised by the dentist.Cosmetics: Substances intended to be applied to the human body for cleansing, beautifying, promoting attractiveness, or altering the appearance without affecting the body's structure or functions. Included in this definition are skin creams, lotions, perfumes, lipsticks, fingernail polishes, eye and facial makeup preparations, permanent waves, hair colors, toothpastes, and deodorants, as well as any material intended for use as a component of a cosmetic product. (U.S. Food & Drug Administration Center for Food Safety & Applied Nutrition Office of Cosmetics Fact Sheet (web page) Feb 1995)Counterfeit Drugs: Drugs manufactured and sold with the intent to misrepresent its origin, authenticity, chemical composition, and or efficacy. Counterfeit drugs may contain inappropriate quantities of ingredients not listed on the label or package. In order to further deceive the consumer, the packaging, container, or labeling, may be inaccurate, incorrect, or fake.Fraud: Exploitation through misrepresentation of the facts or concealment of the purposes of the exploiter.Carboxymethylcellulose Sodium: A cellulose derivative which is a beta-(1,4)-D-glucopyranose polymer. It is used as a bulk laxative and as an emulsifier and thickener in cosmetics and pharmaceuticals and as a stabilizer for reagents.Dosage Forms: Completed forms of the pharmaceutical preparation in which prescribed doses of medication are included. They are designed to resist action by gastric fluids, prevent vomiting and nausea, reduce or alleviate the undesirable taste and smells associated with oral administration, achieve a high concentration of drug at target site, or produce a delayed or long-acting drug effect.Ether: A mobile, very volatile, highly flammable liquid used as an inhalation anesthetic and as a solvent for waxes, fats, oils, perfumes, alkaloids, and gums. It is mildly irritating to skin and mucous membranes.Granisetron: A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic for cancer chemotherapy patients.EthersThermoactinomyces: A genus of gram-positive bacteria in the family Thermoactinomycetaceae, that can cause FARMER'S LUNG.Farmer's Lung: A form of alveolitis or pneumonitis due to an acquired hypersensitivity to inhaled antigens associated with farm environment. Antigens in the farm dust are commonly from bacteria actinomycetes (SACCHAROPOLYSPORA and THERMOACTINOMYCES), fungi, and animal proteins in the soil, straw, crops, pelts, serum, and excreta.Actinomycetales: An order of gram-positive, primarily aerobic BACTERIA that tend to form branching filaments.Lipofuscin: A naturally occurring lipid pigment with histochemical characteristics similar to ceroid. It accumulates in various normal tissues and apparently increases in quantity with age.Retinal Pigment Epithelium: The single layer of pigment-containing epithelial cells in the RETINA, situated closely to the tips (outer segments) of the RETINAL PHOTORECEPTOR CELLS. These epithelial cells are macroglia that perform essential functions for the photoreceptor cells, such as in nutrient transport, phagocytosis of the shed photoreceptor membranes, and ensuring retinal attachment.Retinoids: A group of tetraterpenes, with four terpene units joined head-to-tail. Biologically active members of this class are used clinically in the treatment of severe cystic ACNE; PSORIASIS; and other disorders of keratinization.Retinal Degeneration: A retrogressive pathological change in the retina, focal or generalized, caused by genetic defects, inflammation, trauma, vascular disease, or aging. Degeneration affecting predominantly the macula lutea of the retina is MACULAR DEGENERATION. (Newell, Ophthalmology: Principles and Concepts, 7th ed, p304)Pigment Epithelium of Eye: The layer of pigment-containing epithelial cells in the RETINA; the CILIARY BODY; and the IRIS in the eye.Macular Degeneration: Degenerative changes in the RETINA usually of older adults which results in a loss of vision in the center of the visual field (the MACULA LUTEA) because of damage to the retina. It occurs in dry and wet forms.Niemann-Pick Diseases: A group of autosomal recessive disorders in which harmful quantities of lipids accumulate in the viscera and the central nervous system. They can be caused by deficiencies of enzyme activities (SPHINGOMYELIN PHOSPHODIESTERASE) or defects in intracellular transport, resulting in the accumulation of SPHINGOMYELINS and CHOLESTEROL. There are various subtypes based on their clinical and genetic differences.Niemann-Pick Disease, Type A: The classic infantile form of Niemann-Pick Disease, caused by mutation in SPHINGOMYELIN PHOSPHODIESTERASE. It is characterized by accumulation of SPHINGOMYELINS in the cells of the MONONUCLEAR PHAGOCYTE SYSTEM and other cell throughout the body leading to cell death. Clinical signs include JAUNDICE, hepatosplenomegaly, and severe brain damage.Hospitals, Pediatric: Special hospitals which provide care for ill children.Niemann-Pick Disease, Type C: An autosomal recessive lipid storage disorder that is characterized by accumulation of CHOLESTEROL and SPHINGOMYELINS in cells of the VISCERA and the CENTRAL NERVOUS SYSTEM. Type C (or C1) and type D are allelic disorders caused by mutation of gene (NPC1) encoding a protein that mediate intracellular cholesterol transport from lysosomes. Clinical signs include hepatosplenomegaly and chronic neurological symptoms. Type D is a variant in people with a Nova Scotia ancestry.CaliforniaPick Disease of the Brain: A rare form of DEMENTIA that is sometimes familial. Clinical features include APHASIA; APRAXIA; CONFUSION; ANOMIA; memory loss; and personality deterioration. This pattern is consistent with the pathologic findings of circumscribed atrophy of the poles of the FRONTAL LOBE and TEMPORAL LOBE. Neuronal loss is maximal in the HIPPOCAMPUS, entorhinal cortex, and AMYGDALA. Some ballooned cortical neurons contain argentophylic (Pick) bodies. (From Brain Pathol 1998 Apr;8(2):339-54; Adams et al., Principles of Neurology, 6th ed, pp1057-9)

Opposite behavior of two isozymes when refolding in the presence of non-ionic detergents. (1/1074)

GroEL has a greater affinity for the mitochondrial isozyme (mAAT) of aspartate aminotransferase than for its cytosolic counterpart (cAAT) (Mattingly JR Jr, Iriarte A, Martinez-Carrion M, 1995, J Biol Chem 270:1138-1148), two proteins that share a high degree of sequence similarity and an almost identical spatial structure. The effect of detergents on the refolding of these large, dimeric isozymes parallels this difference in behavior. The presence of non-ionic detergents such as Triton X-100 or lubrol at concentrations above their critical micelle concentration (CMC) interferes with reactivation of mAAT unfolded in guanidinium chloride but increases the yield of cAAT refolding at low temperatures. The inhibitory effect of detergents on the reactivation of mAAT decreases progressively as the addition of detergents is delayed after starting the refolding reaction. The rate of disappearance of the species with affinity for binding detergents coincides with the slowest of the two rate-limiting steps detected in the refolding pathway of mAAT. Limited proteolysis studies indicate that the overall structure of the detergent-bound mAAT resembles that of the protein in a complex with GroEL. The mAAT folding intermediates trapped in the presence of detergents can resume reactivation either upon dilution of the detergent below its CMC or by adding beta-cyclodextrin. Thus, isolation of otherwise transient productive folding intermediates for further characterization is possible through the use of detergents.  (+info)

Antilithiasic effect of beta-cyclodextrin in LPN hamster: comparison with cholestyramine. (2/1074)

Beta-Cyclodextrin (BCD), a cyclic oligosaccharide that binds cholesterol and bile acids in vitro, has been previously shown to be an effective plasma cholesterol lowering agent in hamsters and domestic pigs. This study examined the effects of BCD as compared with cholestyramine on cholesterol and bile acid metabolism in the LPN hamster model model for cholesterol gallstones. The incidence of cholesterol gallstones was 65% in LPN hamsters fed the lithogenic diet, but decreased linearly with increasing amounts of BCD in the diet to be nil at a dose of 10% BCD. In gallbladder bile, cholesterol, phospholipid and chenodeoxycholate concentrations, hydrophobic and lithogenic indices were all significantly decreased by 10% BCD. Increases in bile acid synthesis (+110%), sterol 27-hydroxylase activity (+106%), and biliary cholate secretion (+140%) were also observed, whereas the biliary secretion of chenodeoxycholate decreased (-43%). The fecal output of chenodeoxycholate and cholate (plus derivatives) was increased by +147 and +64%, respectively, suggesting that BCD reduced the chenodeoxycholate intestinal absorption preferentially. Dietary cholestyramine decreased biliary bile acid concentration and secretion, but dramatically increased the fecal excretion of chenodeoxycholate and cholate plus their derivatives (+328 and +1940%, respectively). In contrast to BCD, the resin increased the lithogenic index in bile, induced black gallstones in 34% of hamsters, and stimulated markedly the activities of HMG-CoA reductase (+670%), sterol 27-hydroxylase (+310%), and cholesterol 7alpha-hydroxylase (+390%). Thus, beta-cyclodextrin (BCD) prevented cholesterol gallstone formation by decreasing specifically the reabsorption of chenodeoxycholate, stimulating its biosynthesis and favoring its fecal elimination. BCD had a milder effect on lipid metabolism than cholestyramine and does not predispose animals to black gallstones as cholestyramine does in this animal model.  (+info)

Extraction of cholesterol with methyl-beta-cyclodextrin perturbs formation of clathrin-coated endocytic vesicles. (3/1074)

The importance of cholesterol for endocytosis has been investigated in HEp-2 and other cell lines by using methyl-beta-cyclodextrin (MbetaCD) to selectively extract cholesterol from the plasma membrane. MbetaCD treatment strongly inhibited endocytosis of transferrin and EGF, whereas endocytosis of ricin was less affected. The inhibition of transferrin endocytosis was completely reversible. On removal of MbetaCD it was restored by continued incubation of the cells even in serum-free medium. The recovery in serum-free medium was inhibited by addition of lovastatin, which prevents cholesterol synthesis, but endocytosis recovered when a water-soluble form of cholesterol was added together with lovastatin. Electron microscopical studies of MbetaCD-treated HEp-2 cells revealed that typical invaginated caveolae were no longer present. Moreover, the invagination of clathrin-coated pits was strongly inhibited, resulting in accumulation of shallow coated pits. Quantitative immunogold labeling showed that transferrin receptors were concentrated in coated pits to the same degree (approximately sevenfold) after MbetaCD treatment as in control cells. Our results therefore indicate that although clathrin-independent (and caveolae-independent) endocytosis still operates after removal of cholesterol, cholesterol is essential for the formation of clathrin-coated endocytic vesicles.  (+info)

Cellular cholesterol regulates expression of the macrophage type B scavenger receptor, CD36. (4/1074)

CD36, the macrophage type B scavenger receptor, binds and internalizes oxidized low density lipoprotein (OxLDL), and may potentially play a role in the development of atherosclerosis. We reported that the native and modified low density lipoproteins increased CD36 mRNA and protein ( J. Biol. Chem. 272: 21654-21659). In this study, we investigated the effect of alterations of cellular cholesterol content on macrophage expression of CD36. Depletion of cholesterol by treatment with beta-cyclodextrins (beta-cyclodextrin [beta-CD] and methylated beta-cyclodextrin [MebetaCD]) significantly decreased CD36 mRNA and 125I-labeled OxLDL binding. Conversely, loading macrophages with cholesterol or cholesteryl ester (acetate) with MebetaCD:cholesterol complexes increased CD36 mRNA, 125I-labeled OxLDL binding, and CD36 surface expression as determined by fluorescence activated cell sorting. Thus, CD36 expression paralleled cellular cholesterol levels after removal of cholesterol with beta-cyclodextrins or addition of cholesterol with MebetaCD:cholesterol complexes. Neither cholesterol depletion nor loading altered expression of type A scavenger receptor mRNA. Kinetics studies showed that changes in CD36 mRNA occurred after changes of cellular cholesterol. Neither beta-cyclodextrins nor MebetaCD:cholesterol altered CD36 mRNA half-life in the presence of actinomycin D, suggesting that alterations in CD36 expression by cholesterol occur at the transcriptional level. These experiments demonstrate that CD36 expression is enhanced by cholesterol and down-regulated by cholesterol efflux, and imply that macrophage expression of CD36 and foam cell formation in atherosclerotic lesions may be perpetuated by a cycle in which lipids drive expression of CD36 in a self-regulatory manner.  (+info)

Critical role for cholesterol in Lyn-mediated tyrosine phosphorylation of FcepsilonRI and their association with detergent-resistant membranes. (5/1074)

Tyrosine phosphorylation of the high affinity immunoglobulin (Ig)E receptor (FcepsilonRI) by the Src family kinase Lyn is the first known biochemical step that occurs during activation of mast cells and basophils after cross-linking of FcepsilonRI by antigen. The hypothesis that specialized regions in the plasma membrane, enriched in sphingolipids and cholesterol, facilitate the coupling of Lyn and FcepsilonRI was tested by investigating functional and structural effects of cholesterol depletion on Lyn/FcepsilonRI interactions. We find that cholesterol depletion with methyl-beta-cyclodextrin substantially reduces stimulated tyrosine phosphorylation of FcepsilonRI and other proteins while enhancing more downstream events that lead to stimulated exocytosis. In parallel to its inhibition of tyrosine phosphorylation, cholesterol depletion disrupts the interactions of aggregated FcepsilonRI and Lyn on intact cells and also disrupts those interactions with detergent-resistant membranes that are isolated by sucrose gradient ultracentrifugation of lysed cells. Importantly, cholesterol repletion restores receptor phosphorylation together with the structural interactions. These results provide strong evidence that membrane structure, maintained by cholesterol, plays a critical role in the initiation of FcepsilonRI signaling.  (+info)

Sweet taste responses of mouse chorda tympani neurons: existence of gurmarin-sensitive and -insensitive receptor components. (6/1074)

Inhibitory effects of gurmarin (gur) on responses to sucrose and other sweeteners of single fibers of the chorda tympani nerve in C57BL mice were examined. Of 30 single fibers that strongly responded to 0. 5 M sucrose but were not or to lesser extent responsive to 0.1 M NaCl, 0.01 M HCl, and 0.02 M quinine HCl (sucrose-best fibers), 16 fibers showed large suppression of responses to sucrose and other sweeteners by lingual treatment with 4.8 microM (approximately 20 microg/ml) gur (suppressed to 4-52% of control: gur-sensitive fibers), whereas the remaining 14 fibers showed no such gur inhibition (77-106% of control: gur-insensitive fibers). In gur-sensitive fibers, responses to sucrose inhibited by gur recovered to approximately 70% of control responses after rinsing the tongue with 15 mM beta-cyclodextrin and were almost abolished by further treatment with 2% pronase. In gur-insensitive fibers, sucrose responses were not inhibited by gur, but were largely suppressed by pronase. These results suggest existence of two different receptor components for sweeteners with different susceptibilities to gur in mouse taste cells, one gur sensitive and the other gur insensitive. Taste cells possessing each component may be specifically innervated by a particular type of chorda tympani neurons.  (+info)

Intracellular phosphotyrosine induction by major histocompatibility complex class II requires co-aggregation with membrane rafts. (7/1074)

Cross-linking MHC class II molecules human leukocyte antigen (HLA-DR) on the surface of THP-1 cells was found to induce their entry into the glycolipid-enriched membrane fraction of the plasma membrane. At the cellular level, this resulted in the synergistic co-aggregation of class II with cholera toxin, a marker of membrane rafts. The accompanying induction of intracellular protein tyrosine phosphorylation could be inhibited by treating cells with methyl-beta-cyclodextrin, a drug that chelates membrane cholesterol and thereby disperses membrane rafts. Signaling could also be inhibited by treating cells with the Src-family kinase inhibitor PP1. Together, these results show that the induced association of class II molecules with membrane rafts can contribute to their aggregation on the cell surface and mediate an association with intracellular protein-tyrosine kinases.  (+info)

Comparison of the capacity of beta-cyclodextrin derivatives and cyclophanes to shuttle cholesterol between cells and serum lipoproteins. (8/1074)

Previous studies from this laboratory have demonstrated that low concentrations of cyclodextrins (<1.0 mm), when added to serum, act catalytically as cholesterol shuttles to accelerate the exchange of free cholesterol between cells and serum lipoproteins. As cholesterol shuttles, cyclodextrins have the potential to serve as pharmacological agents for modifying cholesterol metabolism. In the present study, we have quantitated the cholesterol-shuttling capacity of a series of newly synthesized beta-cyclodextrin derivatives (betaCDs), with varying structure, and two double-decker cyclophanes. The general protocol is as follows. [(3)H]cholesterol-labeled CHOK1 cells are incubated for 2 h with the test compounds alone or together with 5% human serum, and efflux of the cellular [(3)H]cholesterol is measured. As methyl beta-cyclodextrin (MbetaCD) served as the basis for comparison, initial experiments were conducted that demonstrated there was a dose-dependent stimulation of cell cholesterol efflux as the concentration of MbetaCD increased, with an EC(50) that was calculated to be 0.05 mm. To determine the cholesterol-shuttling capacity of the newly synthesized compounds, cell cholesterol efflux is measured when the compounds are present alone, at a concentration of 0.05 mm, or together with 5% human serum. Our results demonstrate that the double-decker cyclophanes are the most efficient cholesterol shuttles. Under our experimental conditions, methyl beta-cyclodextrin (MbetaCD) approximately doubles the efflux of cell cholesterol to serum, whereas one of the double-decker cyclophanes produces a 4-fold stimulation in efflux. Four of the beta-cyclodextrin derivatives (betaCDs) display shuttling ability similar to that of MbetaCD. Furthermore, there does not appear to be a structural pattern among the other betaCDs which could explain their shuttling capacity.  (+info)

A multiple regression model was generated, which can satisfactorily estimate the association constants (K-a) for the inclusion complexation of beta-cyclodextrin with mono- and 1,4-disubstituted benzenes. It was found that lnK(a) was correlated with the substituent molar refraction (R-m), hydrophobic constant (pi) and Hammett constant sigma) of the guest compounds with a correlation coefficient of 0.95. The main driving forces for beta-cyclodextrin complexation was concluded to consist of van der Waals forces and hydrophobic interactions, while the influence of electronic effects was small.; A multiple regression model was generated, which can satisfactorily estimate the association constants (K-a) for the inclusion complexation of beta-cyclodextrin with mono- and 1,4-disubstituted benzenes. It was found that lnK(a) was correlated with the substituent molar refraction (R-m), hydrophobic constant (pi) and Hammett constant sigma) of the guest compounds with a correlation coefficient of 0.95. The ...
in Journal of separation science (2015), 38(11), 1813-21. To further evaluate the feasibility and applicability of the one-pot strategy in monolithic column preparation, two novel beta-cyclodextrin-functionalized organic polymeric monoliths were prepared using ... [more ▼]. To further evaluate the feasibility and applicability of the one-pot strategy in monolithic column preparation, two novel beta-cyclodextrin-functionalized organic polymeric monoliths were prepared using two beta-cyclodextrin derivatives, i.e. mono(6-amino-6-deoxy)-beta-cyclodextrin and heptakis(6-amino-6-deoxy)-beta-cyclodextrin. In this improved method, mono(6-amino-6-deoxy)-beta-cyclodextrin or heptakis(6-amino-6-deoxy)-beta-cyclodextrin reacted with glycidyl methacrylate to generate the corresponding functional monomers and were subsequently copolymerized with ethylene dimethacrylate. The polymerization conditions for both monoliths were carefully optimized to obtain satisfactory column performance with respect to column ...
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The plasma membrane of eukaryotic cells contains nanodomains known as lipid rafts. Cholesterol depletion is a widely used technique for studying lipid rafts and their involvement in cellular processes. Cholesterol depletion has been reported to cause both increased and abolished T cell signaling. The abolished cell signaling upon cholesterol depletion is likely to be caused by substantial cell death as demonstrated by cell viability measurements. We have investigated how cholesterol depletion alters T cell activation by analyzing Jurkat T cells upon extraction of 10, 20, 30, 40 and 50% of total cholesterol using methyl β cyclodextrin (MBCD), a protocol in which cholesterol depletion does not have any adverse effect on cell viability.Upon cholesterol depletion peripheral actin polymerization and aggregation of the lipid raft marker GM1 in the plasma membrane is observed. The aggregation of GM1 upon cholesterol depletion is dependent on signaling protein Lck. The aggregated GM1 domains colocalize ...
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1990) Analysis of pseudo-binary solubility diagrams. In: XXI International Conference on Solution Chemistry, 5 - 10 August, Ottawa, Canada ...
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Scientists have identified a -selfish- gene that can potentially remove cholesterol from blood vessels and help prevent heart disease.
Benesi-Hildeband and Jobs plots show the stoichiometry of MBCA:β-CDx complex is 1:1.•XRD study shows MBCA:β-CDx inclusion complex has an amorphous ...
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The aim of present study is to highlight the effects of β-cyclodextrin (BCD) and hydroxypropyl-β-cyclodextrin (HBCD) and also the effect of their concentrations and methods of inclusion complexation on solubility and antibacterial activity of trimethoprim [TMP] by inclusion complex formation. The inclusion complexes of TMP were prepared by solvent evaporation, spray drying, kneading and physical mixture methods in 1:1 and 1:2 ratios. The inclusion complexes were characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), differential scanning calorimetry (DSC), dissolution study and antimicrobial activity by disk diffusion method. Fourier transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD) results proved formation of inclusion complex of TEM with cyclodextrins. XRD showed decrease in crystanality of TEM after complexation with CDs. The results of saturation solubility study and release study prevailed the more increase in solubility of TMP by HPCD than
The interactions of trimethoprim, sulphadiazine and sulphamethoxazole with natural (alpha-, beta-, gamma-) and amorphous (RAMEB) or crystalline (DIMEB) methylated beta-cyclodextrins were investigated both in aqueous solution (using phase-solubility analysis) and in the solid state (using DSC supported by X-ray analysis). In particular, DSC studies enabled determination of the relative degree of crystallinity of each drug in its physical and ground mixtures with the different cyclodextrins on the basis of the variation of its heat of fusion in comparison with that of the pure drug. In all cases, the host cavity size was a prevalent factor for the inclusion complexation in liquid state. On the contrary, it had a negligible effect on solid-state interactions in terms of drug amorphization. DIMEB and RAMEB exhibited similar performances in aqueous solution, showing that the presence of methyl-groups improved the complexing and solubilizing properties of beta-cyclodextrin. However, DSC studies ...
The inclusion complexation of pyrimethamine in 2-hydroxypropyl-beta-cyclodextrin has been investigated by 2D H-1 NMR, FTIR and UV/visible spectroscopy and also by molecular modelling methods (AM1, PM3, MM3). From the phase-solubility diagram a linear increase was observed in pyrimethamine aqueous solubility in the presence of 2-hydroxypropyl-beta-cyclodextrin, evidencing the formation of a soluble inclusion complex. According to the continuous variation method (Jobs plot) applied to fluorescence measurements, a 1:1 stoichiometry has been proposed for the complex. Concerning the structure of the complex, a Cl-in orientation of pyrimethamine in the 2-hydroxypropyl-o-cyclodextrin cavity has been proposed from the theoretical calculations, being confirmed by two-dimensional H-1 NMR spectroscopy (ROESY). The thermal behaviour has also been studied, providing complementary evidences of complex formation. (c) 2007 Elsevier Ltd. All rights reserved ...
The effect of cyclodextrin complexation on the solubility and photostability of nerolidol as pure compound and as main constituent of cabreuva essential oil
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The cholesterol-enriched membrane microdomains lipid rafts play a key role in cell activation by recruiting and excluding specific signalling components of cell-surface receptors upon receptor engagement. Our previous studies have demonstrated that the GPI (glycosylphosphatidylinositol)-linked uPAR [uPA (urokinase-type plasminogen activator) receptor], which can be found in lipid rafts and in non-raft fractions, can mediate the differentiation of VSMCs (vascular smooth muscle cells) towards a pathophysiological de-differentiated phenotype. However, the mechanism by which uPAR and its ligand uPA regulate VSMC phenotypic changes is not known. In the present study, we provide evidence that the molecular machinery of uPAR-mediated VSMC differentiation employs lipid rafts. We show that the disruption of rafts in VSMCs by membrane cholesterol depletion using MCD (methyl-β-cyclodextrin) or filipin leads to the up-regulation of uPAR and cell de-differentiation. uPAR silencing by means of interfering ...
The photochem. behavior of alkyldeoxybenzoins $PhCOCHPhCH_2CH_2R$ (R = H, Me, Et, hexyl, decyl) has been investigated in isotropic org. solvents, in aq. cyclodextrin solns., and bound to cyclodextrin in the solid state. Norrish type I and type II reactions occur in these media and the product distribution resulting from these primary processes are dependent on the medium. In org. solvents, type I and type II products are obtained in equal amts. In aq. cyclodextrin soln., type II products are formed in large excess. In the solid state, type II products constitute more than 90% of the product distribution. Ratios of products resulting from elimination and cyclization from the type II 1,4-diradical are also altered by the host cyclodextrin. Conformational and super-cage effects have been invoked to rationalize the dramatic alteration of the photobehavior of alkyldeoxybenzoins by cyclodextrin.. ...
United This invention relates to complexes, or inclusion compounds, to the preparation of the same, and to edible materials incorporating them. A major problem in the production of convenience foods lies in the difficulty of retaining in the food certain flavors and/or aromas, which, although they may be present in minor amounts, are none the less important. In fact, capturing and preserving for subsequent use the fresh delightful flavors and aromas of fresh edible juices, such as those of freshly picked fruits, leaves and vegetables, is virtually impossible with present-day commercial techniques. Dried leaves, blanched and frozen leaves, dehydrated and frozen fruits and fruit juices, and the like, have been and are used as substitutes, but they fall considerably short of providing the true freshness of the untreated natural material. These flavors and aromas, or notes, which are characteristic of many fresh foods, tend to escape, or undergo change, or be lost in some way, before the food is ...
In this paper, the formation of hydroxypropyl-β-cyclodextrin (HPCD) nanofibers in electrospinning and the adsorption of organic molecules on the HPCD nanofiber were studied. The properties of a polymer-like solution from the highly concentrated HPCD/N,N-dimethylformamide (DMF) solution revealed HPCD supramolecular aggregates formation. The entanglements of HPCD self-organized aggregates were one of the most important factors that significantly influenced fiber formation during cyclodextrin electrospinning. The HPCD self-organized aggregates entanglement concentration (C(e)) was investigated. Analyzing the dependence of specific viscosity (η(sp)) on concentration enabled the determination of the aggregates unentangled and entangled regimes for HPCD polymer-like solutions. The dynamic light scattering (DLS) measurements and the (1)H NMR spectra of the HPCD solutions confirmed the presence of considerable HPCD self-organized aggregates in high concentrated HPCD/DMF solutions due to the intermolecular
This work describes a new microfluidic device developed for the rapid screening of solubility diagrams. In several parallel channels, hundreds of nanolitre volume droplets of a given solution are first stored with a gradual variation in the solute concentration. Then, the application of a temperature gradien
The purpose of this study was to develop and evaluate a solid nonaqueous oral dosage form for a new hepatitis C drug, PG301029, which is insoluble and unstable in water. Hydroxypropyl-β-cyclodextrin...
98458-74-3 - 6-Azobicyclo(3.2.1)octane, 1,3,3,6-tetramethyl-, hydriodide, compd. with beta-cyclodextrin - Similar structures search, synonyms, formulas, resource links, and other chemical information.
The basis for selective tumor targeting of our PDC compounds lies in differences between the plasma membranes of cancer cells as compared to those of most normal cells. Specifically, cancer cell membranes are highly enriched in lipid rafts. Lipid rafts are glycolipoprotein microdomains of the plasma membrane of cells that contain high concentrations of cholesterol and sphingolipids and serve to organize cell surface and intracellular signaling molecules. In vitro studies using fluorescent PDCs (CLR 1501 and CLR 1502) suggest that lipid rafts serve as portals of entry for PDCs. Furthermore, disruption of the lipid raft architecture significantly reduces the uptake of our PLEs into cancer cells. These experiments have also demonstrated the selective uptake and prolonged retention in cancer cells versus non-cancerous cells. This selectivity of our compounds for cancer cells is attributed to the high affinity of the PLE carrier for cholesterol and the abundance of cholesterol-rich lipid rafts in ...
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The inclusion complexes of imazapyr (IMA) with cucurbit[n]uril, CB[n] (n=6-8), have been investigated. Fluorescence spectroscopy, MALDI-TOF, and 1HNMR were used to investigate and characterize the inclusion complexation of IMA and CB[n] in solutions. Whereas the solid state complexes have been characterized by Fourier transform infrared spectroscopy (FTIR), and powder X-ray diffraction (PXRD). IMA was found to form 1:1 complexes with CB[n] with association constants ranging from 5.80×102-2.65×103. The guest molecule IMA was found to encapsulate into the larger cavities of CB[7] and CB[8], whereas with CB[6] the molecule remains outside the cavity ...
Introduction: Cardiac overexpression of muscle specific caveolin-3 (Cav3) protects against ischemic/reperfusion injury through Akt kinase activation. However, the mechanism by which Cav3 regulates Akt activation remains unclear. We tested the hypothesis that Cav3 regulates Akt activity by directly modulating Akt activation loop phosphorylation (T308 in Akt1).. Methods and Results: Adult mouse cardiac myocytes were infected with an adeno-virus that expressed Cav3 and GFP (Ad-GFP/Cav3). In the absence of serum, Cav3 overexpression did not significantly promote T308 phosphorylation. However, when myocytes were stimulated with insulin for 15 minutes, Cav3 synergized with insulin to induce T308 phosphorylation (Ad-GFP-In: 6.9±1.3, Ad-GFP/Cav3-In: 13.7±0.8, p,0.01). The cholesterol-depleting lipid raft inhibitor, cyclodextrin (CyDex), prevented Cav3-mediated Akt activation, suggesting that Cav3 regulates Akt activation through lipid rafts. To test whether lipid rafts directly modulate Akt-T308 ...
The preparation and characterization of a supramolecular host-guest inclusion complex between a fluorescent indolizinyl-pyridinium salt and β-cyclodextrin is reported. The formation of the inclusion complex was investigated by ESI-MS experiments, transmission electron microscopy, Jobs plot investigations an
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3:Equlibrium constant and free energy change of inclusion complexes. SI.No. Inclusion complex of Compound. Equlibrium Constant(KT). ?G(kJ/mole). 1. I.C.K. 2. I.C.L. 3. I.C.M. 4. I.C.N. The data obtained from the ...
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We have recently described a novel cyclic tetrasaccharide of D-glucose (Cote & Biely, Eur. J. Biochem. 226:641-648, 1994), and would like to know if anyone in the carbohydrate chemistry community has any ideas for using it. We would especially like to collaborate with someone who would like to study its ability to complex small molecules or ions. It has practically no internal cavity, so would probably not form inclusion complexes similar to those of cyclodextrins. We can only provide milligram amounts at this time, and only if your idea is interesting and has scientific merit. Please contact me via e-mail or snail mail. Gregory Cote USDA/ARS/NCAUR 1815 N. University St. Peoria, IL 61604 E-mail: cotegl at ncaur1.ncaur.gov ...
I wonder if we need a place for XMRV specific treatments in the treatment secion. Cyclodextrin is currently being used to treat the twins with...
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en] PURPOSE: Ro 28-2653 (RO) is a synthetic inhibitor of matrix metalloproteinases (MMPs), which is potentially effective against bronchial remodeling. Given that this molecule has very poor aqueous solubility, different cyclodextrins (CDs) have been tested to increase its solubility. The aim of this study was to prepare and to characterize inclusion complexes between RO and CDs, in order to develop nebulizable solutions. METHODS: The complex formation was investigated by phase solubility studies. (1)H-NMR spectroscopy and molecular modeling studies were carried out to elucidate the structure of the inclusion complex between RO and dimethyl-beta-CD (DIMEB). Nebulizable solutions of RO were developed with CDs and a stability study was performed over 9 months. RESULTS: The phase solubility studies showed that beta-CD and its derivatives form a 1:2 complex with RO, whereas gamma-CD includes RO with a 1:1 stoichiometry and a weak stability constant. T-ROESY spectra showed that DIMEB is able to ...
In the present paper, the effect of β-cyclodextrin (β-CD) inclusion complexation on the solubility and enzymatic hydrolysis of naringin was investigated. The inclusion complex of naringin/β-CD at the molar ratio of 1:1 was obtained by the dropping method and was characterized by differential scanning calorimetry. The solubility of naringin complexes in water at 37 ± 0.1 °C was 15 times greater than that of free naringin. Snailase-involved hydrolysis conditions were tested for the bioconversion of naringin into naringenin using the univariate experimental design. Naringin can be transformed into naringenin by snailase-involved hydrolysis. The optimum conditions for enzymatic hydrolysis were determined as follows: pH 5.0, temperature 37 °C, ratio of snailase/substrate 0.8, substrate concentration 20 mg·mL−1, and reaction time 12 h. Under the optimum conditions, the transforming rate of naringenin from naringin for inclusion complexes and free naringin was 98.7% and 56.2% respectively, suggesting
This study reports the formation of solid vanillin/cyclodextrin inclusion complexes (vanillin/CD ICs) with the aim to enhance the thermal stability and sustained release of vanillin by inclusion complexation. The solid vanillin/CD ICs with three types of CDs (α-CD, β-CD, and γ-CD) were prepared using the freeze-drying method; in addition, a coprecipitation method was also used in the case of γ-CD. The presence of vanillin in CD ICs was confirmed by FTIR and (1)H NMR studies. Moreover, (1)H NMR study elucidated that the complexation stoichiometry for both vanillin/β-CD IC and vanillin/γ-CD IC was a 1:1 molar ratio, whereas it was 0.625:1 for vanillin/α-CD IC. XRD studies have shown channel-type arrangement for CD molecules, and no diffraction peak for free vanillin was observed for vanillin/β-CD IC and vanillin/γ-CD IC, indicating that complete inclusion complexation was successfully achieved for these CD ICs. In the case of vanillin/α-CD IC, the sample was mostly amorphous and some uncomplexed
Cyclodextrin complex is suspended in polyalkylene glycol carrier material that does not displace the included material. The preferred perfume/cyclodextrin complexes, either alone or admixed with solvent (e.g., water), are preferably suspended in the carrier and then incorporated into solid, dryer-activated, fabric treatment (conditioning) compositions, preferably containing fabric softeners, more preferably cationic and/or nonionic fabric softeners. The perfume complexes provide fabrics with perfume benefits when they are rewetted after drying. Volatile perfume materials, including those materials that are commonly associated with freshness can be applied to the fabrics in an effective way.
DESCRIPTION (provided by applicant): C. perfringens epsilon-toxin (ETX) is a potential biological weapon included in the list of category B priority agents. The overall goal of this proposal is to identify and perform in vivo testing of new inhibitors of E TX using a novel approach for the inactivation of pore-forming toxins developed at Innovative Biologics, Inc. It is based on the blocking of the target pore with molecules having the same symmetry as the pore itself. Results from our SBIR Phase I project d emonstrated that beta-cyclodextrin derivatives designed to block the transmembrane channel formed by epsilon-toxin can inhibit its cytotoxicity at low micromolar concentrations. Based on the successful completion of this feasibility study, we propose to de sign, synthesize and screen a library of beta-cyclodextrin derivatives for inhibitors of epsilon-toxins activity and test selected lead compounds in mice. The specific aims of this Phase II study are: (1) Optimize the assay for testing ...
The solubility of natural cyclodextrins is very poor and initially this prevented cyclodextrins from becoming effective complexing agents. In the late 1960s, it was discovered that chemical substitutions at the 2-, 3-, and 6-hydroxyl sites would greatly increase solubility. The degree of chemical substitution and the nature of the groups used for substitution determine the final maximum concentration of cyclodextrin in an aqueous medium. Most chemically modified cyclodextrins are able to achieve a 50% (w/v) concentration in water.. Cavity size is the major determinant as to which cyclodextrin is used in complexation. "Fit" is critical to achieving good incorporation of cyclodextrins. α-Cyclodextrins have small cavities that are not capable of accepting many molecules. γ-Cyclodextrins have much larger cavities than many molecules to be incorporated, and cyclodextrin hydrophobic charges cannot effectively interact to facilitate complexation. The cavity diameter of β-cyclodextrins has been ...
51166-71-3 - QGKBSGBYSPTPKJ-UZMKXNTCSA-N - Heptakis(2,6-O-dimethyl)beta-cyclodextrin - Similar structures search, synonyms, formulas, resource links, and other chemical information.
where [P]0 denotes the initial concentration of IBU and [CD]0 denotes that of CDs. F and F0 are the fluorescence intensities of IBU in the presence and absence of CDs, respectively. K is a formation constant, k is the instrument constant and Q is the fluorescence quantum yield of the inclusion complex. If the curve of 1/(F-F0) versus 1/[CD]0 exhibits good linearity, it implies that inclusion complexes with a stoichiometry of 1:1 are formed. B. Effect of the types of CDs β-CDs have the hydrophilic outer surface and a hydrophobic internal cavity. The inclusion interaction of β-CDs and the guest molecules is affected by the size of the internal cavity and hydrophilic, hydrophobic characters of the host. It is generally believed that dipole-dipole, electrostatic, van der Walls forces, hydrogen bonding, hydrophobic interaction, and the release of distortion energy of CD ring upon guest binding cooperatively govern the stability of an inclusion complex. The effect of HP-β-CD concentration on the ...
Piroxicam-Beta-Cyclodextrin is made by enwrapping medical piroxicam and medical beta-cyclodextrin in a certain inverse proportion with a unique art. This inclusion compound has less odor, more stability and more stable medicine releasing speed than the si
Equilibrium constants and standard enthalpies have been measured calorimetrically for the formation of complexes of α-and β-cyclodextrins with substituted phenols in aqueous solutions at 298.15 K. The study includes variation of the size and shape of the phenol, the size and degree of methylation of the cyclodextrin, and the effects of pH and ionic strength. Substituent effects were measured for p-chloro-, p-bromo-, p-methyl-, p-hydroxy-, p-nitro- and m-nitrophenols. The effects of ionization were studied with m- and p-nitrophenolate ions. The effects of methyl substitutions of β-cyclodextrin were investigated with nitrophenol and nitrophenolate ions complexing with heptakis(2,6-di-O-methyl)-β-cyclodextrin and heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin. All of the effects studied show a substantial amount of entropic-enthalpic compensation, such that free energy effects are relatively small in comparison to enthalpic and/or entropie effects, but there was no simple relationship between the
Our understanding of the structure of the plasma membrane of mammalian cells was based on the Singer-Nicolson fluid mosaic membrane model, where all the constituents of the membrane move freely ( Singer and Nicolson, 1972). In recent years the Singer-Nicolson membrane model has been changed by demonstrations of lateral heterogeneities, patches and domains in the plasma membrane ( Edidin, 1996; Jacobson et al., 1995; Kusumi and Sako, 1996). These lateral heterogeneities of the plasma membrane, often called `lipid rafts, are emerging as sites of cellular signalling.. In this study we decided to investigate the significance of raft formation in LPS-mediated cellular activation. Using biochemical techniques in order to isolate lipid rafts on the basis of their insolubility in Triton X-100 and low buoyant density centrifugation, we isolated lipid rafts before and after LPS stimulation. Certain molecules involved in the innate recognition of bacteria, such as CD14 and hsp70 and 90, were ...
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3804 Introduction: Inadequate tumor vascularization and/or anti-vascular effects of cancer chemotherapy contribute to anticancer drugs failure. We pursued physiological drug resistance of cancer chemotherapy in mouse breast cancer models using magnetic resonance imaging (MRI) and spectroscopic imaging (MRSI). Methods: All animal experiments were conducted according to the institutional guidelines. Anesthetized SCID mice with orthotopic MCF-7 breast cancer were immobilized in the probe and maintained under gas anesthesia (Isoflurane 0.5%, 1 l/min). 13C-Labeled-temozolomide ([13C]TMZ) or temozolomide (TMZ: Temodar® capsule), alkylating agent, was used as a model drug. Two hundred microliter of [13C]TMZ (50 mM)/dimethyl-β-cyclodextrin (100 mM) inclusion complex was infused into the mouse via an i.p. catheter. Three-dimensional indirect 1H/13C MRSI was performed with an 8x8x8 matrix for a 16 mm isotropic field of view. During 3D map acquisition, a total of 400 μl of inclusion complex was ...
Branched cyclodextrins are produced by the pyrolysis of cyclodextrins. The temperature range is 135 C. to 220 C. using equipment suitable for making British gum and other starch dextrins.
This paper showed the synthesis of biocompatible micelles from linear-hyperbranched supramolecular amphiphiles which were formed by inclusion complexation between HPHEEP-MV, PLA-IPA and CB ...
Blood clot in the left leg, have been on warfarin 7 months, leg calf still swells up, and wondering if the medication warfarin removes cholesterol as well.
The rotation of close binary system components is investigated. The principal physical characteristics as well as the equatorial rotational velocities and
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ß-Cyclodextrin, base (BCD) for biochemistry & microbiology datasheet and description hight quality product and Backed by our Guarantee
There is disclosed a rubber composition comprising: (A) 100 parts by weight of at least one rubber containing olefinic unsaturation; and (B) 1.5 to 50 phr of a cyclodextrin compound.
A61K47/69-Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit ...
Cannizzo, C., Adonopulos, A., Solly, E., Ridiandries, A., Vanags, L., Mulangala, J., Yuen, S., Tsatralis, T., Henriquez, R., Robertson, S., Ng, M., Lam, M., Bursill, C., Tan, J., et al (2018). VEGFR2 is activated by high-density lipoproteins and plays a key role in the proangiogenic action of HDL in ischemia. FASEB Journal, 32(6), 2911-2922. [More Information] ...
Lipid rafts, microdomain heterogeneity and inter-organelle contacts: impacts on membrane preparation for proteomic studies.: In recent years, there has been con
BREAKING UP A RAFT IN THE GEORGIAN BAY, WITH NINETEEN MEN ON IT. Last Monday night Mr. COATSWORTH, of Toronto, and 18 of his men, had a narrow and almost miraculous escape from destruction by a breaking up of a raft on which they were floating on the Georgian Bay ...
     Natamycin is an antimycotic with very low water solubility and extremely high photosensitivity, which is used to extend the shelf life of shredded cheese products. The objectives of this research are: (a) to find a new delivery system for natamycin, which increases its aqueous solubility and (b) to increase the chemical stability of natamycin so that it has a prolonged antifungal effect on the surface of the shredded cheese..      Molecular inclusion complexes of natamycin were formed with b-, hydroxypropyl b-, and g-cyclodextrins (CDs) which allowed large increases in aqueous solubility without the use of organic co-solvents or surfactants. The water solubility of natamycin was increased 16-fold, 73-fold, and 152-fold with b-CD, g-CD, and hydroxypropyl b-CD, respectively. The natamycin:CD inclusion complexes resulted in nearly equivalent in vitro antifungal activity as natamycin in its free state. Nuclear magnetic resonance (NMR) was utilized to prove the formation of ...
Paracetamol is a sparingly soluble bitter tasting drug. It is widely used as an analgesic and antipyretic. Complexation of drug with different cyclodextrins (?, ? and HP-?-CD) was attempted to improve solubility of Paracetamol. During the drug excipient interaction studies, ?, ? cyclodextrins elicited analytical interference and showed considerable absorbance at ?max (243.5 nm) of Paracetamol while the ones constituting of hydroxypropyl-beta-cyclodextrin (HP-?-CD) did not show any such interference. Therefore, the present study is concentrated on exploring HP-?-CD as complexing agent. Phase solubility studies showed that complexation of Paracetamol/HP-?-CD at molar ratio 1:1 and showed AL type solubility curve. Complexation was done by various methods like physical mixing, kneading and freeze drying and resulting drug complexes were characterized by Differential Scanning Calorimetry (DSC) and Fourier Transform Infrared Spectroscopy (FTIR). The thermograms obtained showed an endothermic peak for
The solubility of β-cyclodextrin (β-CD) in ionic liquids (ILs) and the activity coefficients at infinite dilution () of more than 20 solutes (alkanes, aromatic hydrocarbons, alcohols) were measured in four chosen ionic liquids, their mixtures with β-CD, and in the β-CD at high temperatures from 338 to 398 K using the inverse gas chromatography. The intermolecular interactions, inclusion complexes and the possible increasing of the solubility of β-CD in water using the IL are presented. The solubility of β-CD in ten chosen hydrophobic ILs at the temperature T = 423 K was detected. The solid-liquid phase diagrams (SLE) of {IL (1) + β-CD (2)} binary systems at the high mole fraction of the IL were measured for three systems (1-ethyl-3-methylimidazolium chloride, [EMIM][Cl], 1-ethyl-3-methylimidazolium bromide, [EMIM][Br]; and for 1-butyl-3-methylimidazolium chloride, [BMIM][Cl]). The eutectic points were determined at the high IL concentration for all binary systems. The intermolecular
Enantioseparation has attracted considerable attention in biological science and pharmaceutical industry because of the different physiological activity and pharmacological effects of different enantiomers (1). Amongst many analytical techniques, capillary electrophoresis (CE) is a relatively new separation technique that provides rapid analysis with high efficiency and resolution due to the use of electric field and a variety of selective modes (2). Cyclodextrins are the most commonly utilized chiral selectors added into the background electrolyte to perform enantioseparation. Besides neutral CDs derivatives, the synthesis and application of charged CDs derivatives have become attractive due to their good water solubility and excellent enantiorecognition abilities towards counter-charged racemic analytes (3,4). Previously, our group has developed a series of positive changed single isomer CD selectors which afforded good enantioseparation abilities to anionic and ampholytic acids by CE (5,6,7). ...
TY - JOUR. T1 - Interactions between cyclodextrins and cell-membrane phospholipids. AU - Szejtli, J.. AU - Cserháti, T.. AU - Szögyi, M.. PY - 1986. Y1 - 1986. N2 - The interactions between cyclodextrins (CDs) and selected cell membrane phospholipids, liposomes and human erythrocytes were studied. Non-methylated cyclodextrins did not influence the differential scanning calorimetric behaviour of phospholipids and did not increase the permeability of dipalmitoyl-phosphatidyl-choline liposomes. Dimethyl- and trimethyl- β-CD interacted with the phospholipids but the effect was negligible compared to the effect of valinomycin. Reversed-phase thin-layer chromatography revealed complex formation with dimethyl-β-cyclodextrin, but not with others. The addition of cyclodextrins up to 10-2 mol litre-1 concentration did not modify the active or passive alkali ion transport of human erythrocytes, however, higher concentrations of added β-cyclodextrin especially dimethyl-β-cyclodextrin resulted in ...
Natures fastest motors are the cochlear outer hair cells (OHCs). These sensory cells use a membrane protein, Slc26a5 (prestin), to generate mechanical force at high frequencies, which is essential for explaining the exquisite hearing sensitivity of mammalian ears. Previous studies suggest that Slc26a5 continuously diffuses within the membrane, but how can a freely moving motor protein effectively convey forces critical for hearing? To provide direct evidence in OHCs for freely moving Slc26a5 molecules, we created a knockin mouse where Slc26a5 is fused with YFP. These mice and four other strains expressing fluorescently labeled membrane proteins were used to examine their lateral diffusion in the OHC lateral wall. All five proteins showed minimal diffusion, but did move after pharmacological disruption of membrane-associated structures with a cholesterol-depleting agent and salicylate. Thus, our results demonstrate that OHC lateral wall structure constrains the mobility of plasma membrane ...
Newcastle disease virus (NDV) belongs to the Paramyxoviridae, a family of enveloped RNA viruses that includes many important human and animal pathogens. Although many aspects of the paramyxovirus life cycle are known in detail, our understanding of the mechanisms regulating paramyxovirus assembly and release are poorly understood. For many enveloped RNA viruses, it has recently become apparent that both viral and host cellular determinants coordinate the proper and efficient assembly of infectious progeny virions. Utilizing NDV as a model system to explore viral and cellular determinants of paramyxovirus assembly, we have shown that host cell membrane lipid raft domains serve as platforms of NDV assembly and release. This conclusion was supported by several key experimental results, including the exclusive incorporation of host cell membrane raftassociated molecules into virions, the association of structural components of the NDV particle with membrane lipid raft domains in infected cells and the
The influence of peptide sequence and Leu chirality in linear and cyclic peptides containing 3-[2-(9-anthryl)benzoxazol-5-yl]alanine on interaction with β-cyclodextrin were studied using fluorescence and NMR spectroscopy. The analysis of enthalpy-entropy compensation effect (α=1.05±0.02 and TΔS00=15.1±0.5 kJ mol−1) indicates that the entropic contribution connected with the solvent reorganization is the major factor governing the peptides-β-cyclodextrin complexation. Moreover, spatial orientation of guest-host molecule depends more than association constant on Leu residue configuration. However, the cyclization of the peptide chain substantially decrease the association constant with β-CD. An analysis of 2D NMR spectra reveals that inclusion complex is formed by penetration of cyclodextrin cavity from wider and narrow rims by anthryl group in the case of Box(Ant)-SPKL or anthryl and Leu residues for Box(Ant)-SPK(D)L analogue ...
A functionally diverse set of cell surface proteins, including receptors, adhesion molecules, and enzymes, become insoluble to extraction in the detergent Triton X-100 as they traverse the secretory pathway and are delivered to the plasma membrane (PM). Acquisition of resistance to detergent extraction is thought to correspond to assembly into stable microdomains, which can be conceptualized as lipid rafts floating in the membrane (Simons and Ikonen 1997; Pralle et al. 2000). Purification of detergent-resistant membranes shows that they are enriched in sterols, glycosphingolipids, sphingolipids, saturated phospholipids, and glycosyl phosphatidyl inositol (GPI)-anchored proteins (Simons and Ikonen 1997; Brown and London 1998). Lipid rafts, as defined by detergent resistance, have been associated with sorting of proteins bound for the cell surface during exit from the Golgi complex, as well as with organization of signaling molecules on the cell surface (Simons and Ikonen 1997; Stauffer and Meyer ...
This is a report focusing on further development of a synthetic catalyst for hydrolysis of the phosphate ester bonds in RNA. The main goal was to construct a catalyst based on a cyclodextrin ligand suitable for carrying a lanthanide metal with the induced capability to hydrolyse the stable phosphate ester bonds in RNA. This was achieved through a six-step synthesis resulting in a lanthanide-salen-cyclodextrin complex. For simplicity in the product analysis of the reaction, adenosine diribonucleotide (ApA) was used as a model substrate for RNA. The hydrolysis was performed at 20°C and ph7 to mimic physiological conditions in the human body. The results showed indications that it was possible to hydrolysis RNA by this kind of complex.. ...
Lipid rafts, also called detergent-resistant domains, are plasma membrane microdomains characterized by insolubility in nonionic detergents (at cold temperatures) and enrichment in cholesterol and sphingomyelin (16, 17). They range from a few nanometers to a few hundred nanometers in diameter and represent ∼50% of cellular membrane (16, 18). Certain proteins reside preferentially in rafts, whereas others are recruited or excluded from the rafts upon cell activation (16, 17, 18, 19, 20, 21). By protein composition, the lipid rafts are heterogeneous: some are enriched in caveolin and others concentrate clathrin and GPI-anchored proteins or dynamin (16, 17). It is generally believed that lipid rafts provide platforms for formation of receptor complexes, their internalization and triggering of signaling pathways, thus facilitating cell activation (19, 21). Lipid rafts had not yet been characterized when most of the experimental evidence was obtained to evaluate the hypothesis that EtOH produces ...
As endothelial cells form the barrier between blood flow and surrounding tissue, many of their functions depend on mechanical integrity, in particular that of the plasma membrane. As component and organizer of the plasma membrane, cholesterol is a regulator of cellular mechanical properties. Disruption of cholesterol balance leads to impairment of endothelial functions and eventually to disease. The mechanical properties of the membrane are strongly affected by the cytoskeleton. As Phosphatidylinositol-4,5-bisphosphate (PIP2) is a key mediator between the membrane and cytoskeleton, it also affects cellular biomechanical properties. Typically, PIP2 is concentrated in cholesterol-rich microdomains, such as caveolae and lipid rafts, which are particularly abundant in the endothelial plasma membrane. We investigated the connection between cholesterol and PIP2 by extracting membrane tethers from bovine aortic endothelial cells (BAEC) at different cholesterol levels and PIP2 conditions. We provide strong
The interaction between a T cell and an antigen-presenting cell (APC) can trigger a signaling response that leads to T cell activation. Prior studies have shown that ligation of the T cell receptor (TCR) triggers a signaling cascade that proceeds through the coalescence of TCR and various signaling molecules (e.g., the kinase Lck and adaptor protein LAT [linker for T cell activation]) into microdomains on the plasma membrane. In this study, we investigated another ligand-receptor interaction (CD58-CD2) that facilities T cell activation using a model system consisting of Jurkat T cells interacting with a planar lipid bilayer that mimics an APC. We show that the binding of CD58 to CD2, in the absence of TCR activation, also induces signaling through the actin-dependent coalescence of signaling molecules (including TCR-zeta chain, Lck, and LAT) into microdomains. When simultaneously activated, TCR and CD2 initially colocalize in small microdomains but then partition into separate zones; this ...
The beneficial effects of the Mas/Ang-(1-7) pathway prompted us to develop novel Ang-(1-7) analogues and ligands for Mas. In the present study, we evaluated the cardiometabolic effects of a pharmacological formulation developed by including the Mas agonist A-1317 in hydroxypropyl β-cyclodextrin (HPβCD). The inclusion compound was given orally (10 μg/Kg body weight) to Spontaneously hypertensive rat (SHR) and fructose-fed rats. Mean arterial pressure (MAP) and heart rate (HR) were monitored for 5 hours after administration of a single dose of A-1317-HPβCD in conscious SHR. Seven-weeks-old male Sprague-Dawley rats were fed with either normal rat chow (CTL) or the same diet plus 10% fructose in the drinking water (FFR). For the last 4 wk of a 9-wk period of each diet, a subgroup of each group of animals was treated daily with the oral A-1317 (CTL-A or FFR-A) or with vehicle (CTL-V or FFR-V). Rats were subjected to oral glucose tolerance test (2 g/Kg body weight) concomitantly with the ...
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TY - GEN. T1 - Branching of cyclodextrins with various mono-, di-, and tri-saccharides by Bacillus acidophilus pullulanase.. AU - Madsen, U.. AU - Larsen, Kim Lambertsen. PY - 2002. Y1 - 2002. KW - Bioteknologi. KW - Bioteknologi. M3 - Article in proceeding. BT - Third Nordic Starch network Symposium. PB - Denmark.. ER - ...
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Thomas, PD and Podder, SK (1978) Specificity in proteinânucleic acid interaction: Solubility study on amino acidânucleoside interaction. In: FEB Letters, 96 (1). pp. 90-94. Thomas, PD and Podder, SK (1978) Specificity in protein-nucleic acid interaction: Solubility study on amino acid-nucleoside interaction. In: FEBS Letters, 96 (1). pp. 90-94. ...
Publication Details (including relevant citation information): Nociari, M.M., Lehmann, G.L., Perez Bay, A.E., Radu, R.A., Jiang, Z., Goicochea,
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Reduction of the cholesterol level in membranes of epithelial Madin-Darby canine kidney (MDCK) cells reverses the apical-to-basolateral transport ratio of the apical membrane marker protein influenza virus haemagglutinin and the secreted glycoprotein gp80. At the same time, basolateral transport of the vesicular stomatitis virus G protein is unaffected [Keller and Simons (1998) J. Cell Biol. 140, 1357-1367]. To investigate whether cholesterol depletion influences apical sorting mechanisms specifically, or apical transport capacity more generally, we studied the effect of cholesterol depletion on the secretion of three different classes of molecules from the apical and basolateral surfaces of MDCK cell layers: glycoprotein gp80, sulphated proteoglycans and proteins, and non-glycosylated rat growth hormone. In each case, cholesterol depletion reduced the fraction secreted to the apical medium and increased the fraction secreted basolaterally. The fact that this was observed for all sulphated ...
Novel supramolecular hydrogels were formed between pyrene-terminated poly(ethylene glycol) star polymers and γ-cyclodextrin (γ-CD), through the inclusion complexation of dimers of the pyrene terminals with γ-CD, where γ-CD was directly used as a supramolecular cross-linking reagent without any modification. © 2012 The Royal Society of Chemistry ...
In the present work the inclusion complexation of three sulfonamide (SA) drugs, namely sulfisoxazole (SSX), sulfamethizole (SMZ), and Sulfamethazine (STM) with ?-cyclodextrin (?-CD) has been investigated using UV-Vis spectroscopy, DSC, 1H NMR spectroscopy, and molecular modeling methods. The binding constant (Kb) of SA:?-CD inclusion complexation was determined via applying the modified form of Benesi-Hildebrand equation employing the changes in absorbance at ?max. Obtained results revealed that SA drugs form 1:1 inclusion complex with ?-CD with Kb of 650, 1532, 714 M-1 at 25 �C for SSX, SMZ, and STM, respectively. The UV-Vis absorption spectra displayed solvatochromic behavior of bathochromic shift with decreasing solvent polarity that in turn is good agreement with their behavior in the presence of ?-CD in terms of environment polarity dependency. The inclusion complex formation between ?-CD and tested SA drugs in liquid and solid states was confirmed by 1H NMR and DSC, respectively. Using ...
A dual retention combined with reversed-phase liquid chromatography (RP-LC) and hydrophilic interaction chromatography (HILIC) has been observed on beta-cyclodextrin (beta-CD) bonded stationary phase. A typical U-shaped retention curve was achieved owing to dual retention mechanism Based on this observation, a beta-CD column can be operated under reversed-phase liquid chromatography (RP-LC) and hydrophilic interaction chromatography (HILIC) modes. Two-dimensional liquid chromatography (2D-LC) analysis can be realized on Just a beta-CD column by switching these two different separation modes. In this study, off-line 2D-LC analysis for a natural product was carried out to prove the orthogonal separation between RP-LC and HILIC modes on a Click beta-CD column. Herba Hedyotis Diffusae, the whole grass of Hedyotis Diffusae wild was extracted with water, pretreated with macroporous resin and then first separated at RP-LC mode on the Click beta-CD column to obtain successive fractions, which were then ...
Crosslinking of Fc epsilon RI on rat basophilic leukemia (RBL 2H3) cells leads to an increase in Phosphatidylinositol 4-kinase activity. This increase in Ptdlns 4-kinase activity is strongly correlated with its tyrosyl phosphorylation state. Characterization of the enzyme activity in anti phosphotyrosine immunoprecipitates suggests it as a type II Ptdlns 4-kinase. Membrane cholesterol depletion studies showed a reduction in type II Ptdlns 4-kinase activity suggesting that lipid rafts play an important role in activation of the enzyme. The enzyme activity was inhibited by resveratrol. In situ inhibition of type II Ptdlns 4-kinase activity showed a reduction in beta-hexosaminidase release upon Fc epsilon RI cross-linking. These studies suggest that a type II Ptdlns 4-kinase is an integral component of Fc epsilon RI mediated signal transduction mechanisms. (c) ...
Cyclodextrins (sometimes called cycloamyloses) are a family of compounds made up of sugar molecules bound together in a ring (cyclic oligosaccharides). Cyclodextrins are produced from starch by enzymatic conversion. They are used in food, pharmaceutical, drug delivery, and chemical industries, as well as agriculture and environmental engineering. α-Cyclodextrin is a soluble dietary fiber used as an ingredient in commercial food products. Cyclodextrins are composed of 5 or more α-D-glucopyranoside units linked 1->4, as in amylose (a fragment of starch). The largest cyclodextrin contains 32 1,4-anhydroglucopyranoside units, while as a poorly characterized mixture, at least 150-membered cyclic oligosaccharides are also known. Typical cyclodextrins contain a number of glucose monomers ranging from six to eight units in a ring, creating a cone shape: α (alpha)-cyclodextrin: 6-membered sugar ring molecule β (beta)-cyclodextrin: 7-membered sugar ring molecule γ (gamma)-cyclodextrin: 8-membered ...
Communications Enantiomer Separation Modified Linear Dextrins ("Acyclodextrins") as New Chiral Selectors for the GasChromatographic Separation of Enantiomers** Giuseppe Sicoli, Zhengjin Jiang, Laszlo Jicsinsky, and Volker Schurig* In memory of Jzsef Szejtli Cyclodextrins (CDs) modified by alkylation, acylation, and silylation represent versatile chiral stationary phases (CSPs) for the gas-chromatographic separation of enantiomers.[1] Typically, they are dissolved in semipolar polysiloxanes[2a] or linked chemically to polydimethylsiloxane (Chirasil-Dex).[2b] The mechanism of enantiomer recognition is still not well understood, and the role of the CD cavity is unclear in cases were enantioselectivity is low, as it is in most reported cases (a , 1.1).[1a] We therefore conjectured that the existence of a cavity may not be a prerequisite to chirality recognition in cyclodextrins. This has now been borne out by employing linear dextrins ("acyclodextrins") as a new generation of carbohydrate-based ...
A suitable host-guest inclusion complex has beenmade with a guest molecule, 1-methyl-3- octylimidazolium chloride ([MOIm]Cl) and a host molecule, α-cyclodextrin in aqueous medium. Formation of the host-guest inclusion complex has been established by Surface tension and conductivity readings while1H NMR and ultraviolet spectroscopy readingconfirms1:1 host-guest stoichiometry. These results have implications for the formation of host-guest inclusion complex of studied ionic liquid as guest in aqueous α-cyclodextrin media.. ...
Lipid rafts are densely packed, floating asemblages of cholesterol, sphingolipid and mostly receptor proteins that are present within cell membranes and that function in membrane trafficking and signaling [30]. Among other things, lipid rafts play critical roles in viral entry, replication, assembly and budding, as well as in protein transport [31]. Cholesterol is a key component of lipid rafts that compartmentalize cellular processes. Further, changes in cellular cholesterol levels have been linked to alterations in the infection process of numerous viruses where the cholesterol dissipative agent, MβCD, has been used to evaluate cholesterol-enriched lipid rafts in virus infection. MβCD is a strictly surface-acting agent that rapidly removes cholesterol from the plasma membrane. Some non-enveloped viruses, such as members of Picornaviridae and Reoviridae, are assembled in the cytoplasm and released by cell lysis. However, evidence has been advanced showing that exit from infected cells can ...
TY - JOUR. T1 - Meta/para-selectivity variation by sulfide/sulfoxide conversion of 6-substituted β-cyclodextrin. Hydrolyses of nitrophenyl acetates. ag. AU - Fujita, Kahee. AU - Ejima, Seiji. AU - Ueda, Tadashi. AU - Imoto, Taiji. AU - Schulten, Hans Rolf. PY - 1984. Y1 - 1984. N2 - Hydrolyses of m- and p-nitrophenyl acetates by 6-deoxy-6-alkylthio-β-cyclodextrins and the corresponding sulfoxides were studied to show that the small chemical conversion from the sulfides to the sulfoxides led to a change of meta/para-selectivity in the hydrolysis of the β-cyclodextrin moiety.. AB - Hydrolyses of m- and p-nitrophenyl acetates by 6-deoxy-6-alkylthio-β-cyclodextrins and the corresponding sulfoxides were studied to show that the small chemical conversion from the sulfides to the sulfoxides led to a change of meta/para-selectivity in the hydrolysis of the β-cyclodextrin moiety.. UR - http://www.scopus.com/inward/record.url?scp=6544223514&partnerID=8YFLogxK. UR - ...
We identified p18 as a potential component of lipid rafts. The predominant distribution of p18 to DRMs suggested its potential localization to lipid rafts. However, it is currently accepted that DRMs do not necessarily correspond to lipid rafts and that the DRM separation method is insufficient for the identification of lipid raft‐associated proteins (Lichtenberg et al, 2005; Hancock, 2006). Thus, to verify the raft localization of p18, we examined intracellular distribution of p18 and its mutants. The cell staining analyses showed that p18 could be colocalized with GM1 ganglioside, a marker of lipid rafts (Harder et al, 1998), and that the N‐terminal potential myristoylation and palmitoylation sites, which are known to function as lipid raft localization signals, were required for the late endosome localization of p18. These observations strongly supported the presence of p18 in lipid rafts of late endosomes (Balbis et al, 2007). It is of interest that the N‐terminal only 20 residues of ...
Capillary electrokinetic chromatography is generally recognized as a versatile and robust capillary electromigration technique for the separation of enantiomers. In this mode, one or more chiral selectors are added to the background electrolyte acting as pseudostationary phases. Within the various chiral selectors that have been applied to enantioseparations in capillary electrokinetic chromatography, cyclodextrins are by far the most often used selectors because of their versatility, structural variety and commercial availability. This is reflected in the large number of applications of cyclodextrins to analytical enantioseparations that have been reported between January 2012 and July 2016, the period of time covered by this review. Many of these applications cover aspects of life sciences such as drug analysis, bioanalysis or food analysis. Despite the large number of commercially available cyclodextrins, new derivatives have been developed in order to achieve altered enantioselectivities or ...
Lien vers Pubmed [PMID] - 15337781. J. Cell Biol. 2004 Aug;166(5):743-53. Listeria monocytogenes uptake by nonphagocytic cells is promoted by the bacterial invasion proteins internalin and InlB, which bind to their host receptors E-cadherin and hepatocyte growth factor receptor (HGF-R)/Met, respectively. Here, we present evidence that plasma membrane organization in lipid domains is critical for Listeria uptake. Cholesterol depletion by methyl-beta-cyclodextrin reversibly inhibited Listeria entry. Lipid raft markers, such as glycosylphosphatidylinositol-linked proteins, a myristoylated and palmitoylated peptide and the ganglioside GM1 were recruited at the bacterial entry site. We analyzed which molecular events require membrane cholesterol and found that the presence of E-cadherin in lipid domains was necessary for initial interaction with internalin to promote bacterial entry. In contrast, the initial interaction of InlB with HGF-R did not require membrane cholesterol, whereas downstream ...
Lipid rafts are cholesterol- and glycosphingolipids- enriched microdomains on plasma membrane surface of mammal cells, involved in a variety of cellular processes. Depleting cholesterol from the plasma membrane by drugs influences the trafficking of lipid raft markers. Optical imaging techniques are powerful tools to study lipid rafts in live cells due to its noninvasive feature. In this study, breast cancer cells MCF-7 were treated with different concentrations of MβCD to deplete cholesterol and an environmentally sensitive fluorescence probe, Laurdan was loaded to image lipid order by two-photon microscopy. The generalized polarization (GP) values were calculated to distinguish the lipid order and disorder phase. GP images and GP distributions of native and cholesterol-depleted MCF-7 cells were obtained. Our results suggest that even at low concentration (0.5 mM) of MβCD, the morphology of the MCF-7 cells changes. Small high GP areas (lipid order phase) decrease more rapidly than low GP ...
Violacein, a pigment isolated from Chromobacterium violaceum, has been reported to have multiple biological activities including in vitro antitumor effects. Certain anticancer agents are known to induce apoptosis in human tumor cell lines. In this work, our aim was to investigate the effectiveness of violacein/β-cyclodextrin (β-CD)-containing systems to produce lethal effects in the human promyelocytic leukemia cell line HL60. Using the MTT tetrazolium reduction test, IC 50 for the inclusion complexes (1:1 and 1:2 violacein:β-CD molar ratios) and violacein alone were less than 1 μM. Violacein and violacein/β-CD complexes were able to induce NBT reduction. Moreover, by using the Feulgen reaction, all the compounds were found to trigger apoptosis in HL60 cells, inducing around 35% of DNA fragmentation, as analyzed through the diphenylamine assay. In addition, caspases seem to play an important role in the activation of the executioner phase of apoptosis induced by violacein and its ...
Lipid rafts enriched in glycosphingolipids (GSLs), cholesterol and signaling molecules play an essential role not only for signal transduction started by ligand binding, but for intracellular events such as organization of actin, intracellular traffic and cell polarity, but their functions in cleavage division of preimplantation embryos are not well known. Here we show that monosialylGb5Cer (MSGb5Cer)-enriched raft domains are involved in development during the cleavage stage of mouse preimplantation embryos. MSGb5Cer preferentially localizes at the interfaces between blastomeres in mouse preimplantation embryos. Live-imaging analysis revealed that MSGb5Cer localizes in cleavage furrows during cytokinesis, and that by accumulating at the interfaces, it thickens them. Depletion of cholesterol from the cell membrane with methyl-beta-cyclodextrin (MbCD) reduced the expression of MSGb5Cer and stopped cleavage. Extensive accumulation of MSGb5Cer at the interfaces by cross-linking with anti-MSGb5Cer Mab (6E2)
Hurley, JC; Volz, SA; Johnston, JJ (1999). "Stabilization of the avicide 3-chloro-p-toluidine as the beta-cyclodextrin adduct ...
The active ingredient in the root was synthesized and encapsulated with beta-cyclodextrins. The roots were also subjected to ...
developed a catalyst based on a beta-cyclodextrin carrying two imidazole groups. This cyclodextrin catalytic system mimics ... Cyclodextrins have rigid ring structure, hydrophilic surface, and hydrophobic cavity on the inside; therefore, they are capable ... From the early 1970s, cyclodextrins have been extensively studied for its encapsulation properties and used as binding sites in ... Self-assembled molecules have an advantage over crown ether and cyclodextrin in that they can capture significant larger ...
The active ingredient in several Febreze products is hydroxypropyl beta-cyclodextrin (HPβCD). The molecule traps and binds ... The use of a cyclodextrin as a sprayable odor absorber is patented by Procter & Gamble. The products include additional ... Uncomplexed cyclodextrin solutions for odor control on inanimate surfaces. US Pat. No. 5,714,137. Filed 1994; assigned 1998. ... Cyclodextrin". Procter&Gamble. 2005. *P&G. (2014). Febreze FAQ (in japanese). Retrieved: http://www.febreze.jp/Faq.aspx?id=4442 ...
Butchbach ME, Guo H, Lin CL (2003). "Methyl-beta-cyclodextrin but not retinoic acid reduces EAAT3-mediated glutamate uptake and ...
"Synthesis and inclusion ability of a bis-beta-cyclodextrin pseudo-cryptand towards Busulfan anticancer agent". Tetrahedron. 63 ... The molecular recognition of ureido-cyclodextrin with busulfan was investigated.[9] The formation of complexes was observed ... Porwanski S, Florence DC, Menuel S, Joly JP, Bulach V, Marsura A (2009). "Bis-beta-cyclodextrinyl- and bis-cellobiosyl- ...
Scalia S, Simeoni S, Barbieri A, Sostero S (November 2002). "Influence of hydroxypropyl-beta-cyclodextrin on photo-induced free ... Formulations of avobenzone with hydroxypropyl-beta-cyclodextrin have shown significant reduction in photo-induced degradation, ... Yang J, Wiley C, Godwin D, Felton L (June 2008). "Influence of hydroxypropyl-β-cyclodextrin on transdermal penetration and ... Complexing avobenzone with cyclodextrins may also increase its photostability. ...
It has been also reported that silymarin inclusion complex with β-cyclodextrin is much more soluble than silymarin itself. ... "Solid state mechanochemical activation of Silybum marianum dry extract with betacyclodextrins: Characterization and ...
... the FDA granted Hydroxypropyl-beta-cyclodextrin orphan drug status and designated HPbCD cyclodextrin as a potential treatment ... In April 2009, hydroxypropyl-beta-cyclodextrin (HPbCD) was approved under compassionate use by the U.S. Food and Drug ... Ward S, O'Donnell P, Fernandez S, Vite CH (July 2010). "2-hydroxypropyl-beta-cyclodextrin raises hearing threshold in normal ... cyclodextrin therapy. On January 23, 2013, a formal clinical trial to evaluate HPβCD cyclodextrin therapy as a treatment for ...
... with dimethyl-beta-cyclodextrin". Chem. Pharm. Bull. 45: 378-83. doi:10.1248/cpb.45.378. PMID 9118452. CS1 maint: Multiple ...
... dendrimers similar to the one in figure 3 have been synthesized and have undergone inclusion complexation by beta-cyclodextrin ...
... from serum with satisfactory yield and used Beta-cyclodextrin as a competitor to displace IgG from the matrix.[18] This largely ... "Salt-independent Hydrophobic Displacement Chromatography for Antibody Purification Using Cyclodextrin as Supermolecular ...
At the moment, apiegnin and beta-cyclodextrin are thought to alleviate S.aureus pneumonia, whereas the antibodies of anti alpha ... Maheswaran SK, Lindorfer RK (November 1967). "Staphylococcal beta-hemolysin. II. Phospholipase C activity of purified beta- ... Unlike beta-hemolysin, it has a higher affinity for phosphocholines with short saturated acyl chains, especially if they have a ...
Derived from this the derivatization of β-cyclodextrin to sulfobutyl ether-beta-cyclodextrin (SBECD) is by now an important ... Sulfobutyl ether-beta-cyclodextrin is a water-soluble inclusion compound for the solubilization and stabilization of sparsely ... Sulfobutyl ether-beta-cyclodextrin also finds a wide range of applications as an inert vehicle for drug delivery (the drugs ... "Evaluation of a sulfobutyl ether beta-cyclodextrin as a solubilizing/stabilizing agent for several drugs", Drug Dev. Ind. Pharm ...
... beta-cyclodextrin) dendrimeric tetrapod as a potential gene delivery (DNA and siRNA) system. Study of cellular siRNA ... Chemical-based transfection can be divided into several kinds: cyclodextrin, polymers, liposomes, or nanoparticles (with or ...
Beta-cyclodextrin sulfate is also useful in limiting restenosis, growth of cells on artery walls that can lead to blockages at ... Joullié helped to synthesize beta-cyclodextrin sulfate, a ring-shaped sugar molecule that attaches to the walls of growing ...
The 3D structure of a complex of soybean beta-amylase with an inhibitor (alpha-cyclodextrin) has been determined to 3.0A ... while the smaller is formed from two long loops extending from the beta-3 and beta-4 strands of the (beta alpha)8 fold. The ... Beta-amylase is present in certain bacteria as well as in plants. Three highly conserved sequence regions are found in all ... Beta-amylase is an enzyme that hydrolyzes 1,4-alpha-glucosidic linkages in starch-type polysaccharide substrates so as to ...
... cyclodextrins MeSH D09.698.365.855.400.375.222 --- alpha-cyclodextrins MeSH D09.698.365.855.400.375.333 --- beta-cyclodextrins ... beta-glucans MeSH D09.698.365.089.500 --- lentinan MeSH D09.698.365.089.625 --- sizofiran MeSH D09.698.365.089.750 --- zymosan ... MeSH D09.698.365.855.400.375.444 --- gamma-cyclodextrins MeSH D09.698.365.855.500 --- hetastarch MeSH D09.698.365.855.750 --- ...
... beta-cyclodextrins MeSH D04.345.103.444 --- gamma-cyclodextrins MeSH D04.345.241.308 --- crown ethers MeSH D04.345.295.500 --- ... File "2006 MeSH Trees".) MeSH D04.345.051.500 --- crown ethers MeSH D04.345.103.222 --- alpha-cyclodextrins MeSH D04.345. ...
... which in turn consists of alternating subunits of beta-cyclodextrin and polyethylene glycol (PEG). The CRLX101 nanoparticle is ... The agent represents a nanoparticle conjugate that consists of a drug delivery molecule, namely a cyclodextrin-based polymer ( ... a cyclodextrin-containing polymer-camptothecin nanopharmaceutical in patients with advanced solid tumor malignancies". Invest. ...
... artificial sweetener beta-cyclodextrin - emulsifier Lemongrass (Cymbopogon citratus, C. flexuosus, and other species) - Damiana ... in Earl Grey tea Beta-apo-8'-carotenal (C 30) - color Beta-apo-8'-carotenic acid ethyl ester - color Betanin - color (red) ... Carotenes - color Alpha-carotene - color Beta-carotene - color Gamma-carotene - color Carrageenan - thickener, vegetable gum, ...
... alpha-cyclodextrin glucanotransferase, alpha-cyclodextrin glycosyltransferase, beta-cyclodextrin glucanotransferase, beta- ... cyclodextrin glycosyltransferase, gamma-cyclodextrin glycosyltransferase, cyclodextrin glycosyltransferase, cyclomaltodextrin ... and neutral-cyclodextrin glycosyltransferase. As of late 2007, 47 structures have been solved for this class of enzymes, with ...
... cellular toxicity and molecular modeling studies of midazolam complexed with trimethyl-beta-cyclodextrin S. Shityakov, T. ... alpha-Cyclodextrin dimer complexes of dopamine and levodopa derivatives to assess drug delivery to the central nervous system: ... Cyclodextrin also forms inclusion compounds with fragrance molecules.[5] As a result, the fragrance molecules have a reduced ... Inclusion complexes are formed between cyclodextrins and different guest molecules[1][2][3] such as ferrocene.[4] When a ...
For example, the Joseph Pitha study showed that when testosterone was complexed with hydroxy-propyl-beta-cyclodextrin (HPBCD), ... Cyclodextrins are used to make pharmaceutical solutions by capturing hydrophobic molecules as guest hosts. Because inclusion ... Stuenkel CA, Dudley RE, Yen SS (May 1991). "Sublingual Administration of Testosterone-Hydroxypropyl-β-Cyclodextrin Inclusion ... and γ-cyclodextrins". International Journal of Pharmaceutics. 179 (1): 65-71. doi:10.1016/S0378-5173(98)00382-2. PMID 10053203 ...
GRN 000155, alpha-cyclodextrin GRAS Notice No. GRN 000074, beta-cyclodextrin GRAS Notice No. GRN 000046, gamma-cyclodextrin ... cyclodextrin: 6-membered sugar ring molecule β (beta)-cyclodextrin: 7-membered sugar ring molecule γ (gamma)-cyclodextrin: 8- ... Alpha-, beta-, and gamma-cyclodextrin are all generally recognized as safe by the FDA. In the food industry, cyclodextrins are ... Beta-cyclodextrin complexes with certain carotenoid food colorants have been shown to intensify color, increase water ...
There are two other naturally occurring cyclodextrins, β (beta) - and γ (gamma) -, which contain seven and eight glucose units ... alpha-Cyclodextrin (α-dextrin, α-cyclodextrin, α-CD, alphadextrin, alpha cyclodextrin (dietary fiber)) is a polysaccharide of ... The ratio for α-cyclodextrin is actually closer to 1:9 (fiber:fat ratio). Trichard et al. have demonstrated that α-cyclodextrin ... CGTases can synthesize all forms of cyclodextrins, thus for the production of the α-cyclodextrin, one specific enzyme must be ...
The role of cholesterol in such endocytosis can be investigated by using methyl beta cyclodextrin (MβCD) to remove cholesterol ...
... stearyldimoniumhydroxypropyl or hydroxypropyltrimonium Cyclodextrin, which may be produced from starch by means of enzymatic ... malt extract Phytosphingosine extract Amino peptide complex prolamine Beta glucan Disodium wheat Germamido PEG-2-Sulfosuccinat ...
Beta cyclodextrins bind and remove A2E from RPE. Marcelo M. Nociari, Guillermo L. Lehmann, Andres E. Perez Bay, Roxana A. Radu ... Beta cyclodextrins bind and remove A2E from RPE. Marcelo M. Nociari, Guillermo L. Lehmann, Andres E. Perez Bay, Roxana A. Radu ... Beta cyclodextrins bind, stabilize, and remove lipofuscin bisretinoids from retinal pigment epithelium. Marcelo M. Nociari, ... Here we report that a family of modified cyclic oligosaccharides, beta cyclodextrins (β-CDs), formed by seven d-glucose units, ...
Looking for TCI AMERICAS Trimethyl-Beta-Cyclodextrin, 1g (19XC33)? Graingers got your back. Price:$159.65. Easy ordering & ...
A wide variety of beta-cyclodextrin options are available to you, such as food grade, cosmetic grade, and tech grade. ... Alibaba.com offers 5,826 beta-cyclodextrin products. About 48% of these are auxiliaries and other medicinal chemicals, 26% are ... sulfobutyl ether beta-cyclodextrin sulfobutylether beta-cyclodextrin gmp beta-cyclodextrin glucose beta-cyclodextrin beta- ... beta-cyclodextrin top purity beta-cyclodextrin high purity beta-cyclodextrin top quality beta-cyclodextrin beta-cyclodextrin ...
See Also: Toxicological Abbreviations Beta-Cyclodextrin (WHO Food Additives Series 32) beta-CYCLODEXTRIN (JECFA Evaluation) ... HRC (1994b). Beta-cyclodextrin: Toxicity to dogs by repeated dietary administration for 52 weeks. Unpublished report no. ROQ 3/ ... HRC (1994a). Beta-cyclodextrin: Toxicity to rats by dietary administration for 52 weeks. Unpublished report no. ROQ 4/931090 ... Pharmakon Europe (1994). Beta-cyclodextrin: Three generation oral (dietary administration) reproduction toxicity study in the ...
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Roquette is a pioneer in the industrial development of Betacyclodextrins, bio-transformation of starch. , Roquette ... Hydroxypropyl BetacycloDextrins KLEPTOSE®. KLEPTOSE® HP and HPB, Roquettes Hydroxypropyl betacyclodextrins (HPBCD), are highly ... Roquette is a pioneer in the industrial development of Betacyclodextrins. These employ the bio-transformation of starch that ...
Popular Products of Sodium Sulfobutyl Ether Beta Cyclodextrin SBECD 128410-00-0 by Betadex sulfobutyl ether sodium - Shandong ... Sodium Sulphobutylether Beta Cyclodextrin. 1.Sodium Sulphobutylether-β-Cyclodextrin is an important modified production of Beta ... 3.Sodium Sulphobutylether-Beta-Cyclodextrin has its own characteristics in addition to the ones Beta-Cyclodextrin has.. 4. ... We have 4 series (Medical Cyclodextrins, Cyclodextrin Reagents, Cyclodextrin Complexes, Cyclodextrin Polymers ) of more than 40 ...
Beta-cyclodextrins (β-cds) are particularly efficient sterol acceptors, apparently because the size of their inner hydrophobic ... Chlorhexidine (Cx) augmented with beta-cyclodextrin (β-cd) inclusion compounds, termed Cx:β-cd complexes, have been developed ... Hence, in order to reduce the toxicity caused by high concentrations of Cx, chlorhexidine:beta-cyclodextrin (Cx:β-cd) complexes ... 9. Cortés, M.E.; Sinisterra, R.D.; Ávila-Campos, M.J.; Tortamano, N.; Rocha, R.G. (2001). The chlorhexidine:beta-cyclodextrin ...
Keywords: hydrogel microparticles, rosuvastatin calcium, polymerization, β-cyclodextrin solubility ... calcium by developing β-cyclodextrin-g-poly(2-acrylamido-2-methylpropane sulfonic acid [AMPS]) hydrogel microparticles through ... Development of beta-cyclodextrin-based hydrogel microparticles for solubility enhancement of rosuvastatin: an in vitro and in ... Development of β-cyclodextrin-based hydrogel microparticles for solubility enhancement of rosuvastatin: an in vitro and in vivo ...
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Since beta-cyclodextrin is. Answer: Since beta-cyclodextrin is complexed with glipizide for better dissolution, there is ... Pharmaceutical Information » Question Category » Pharma Industry » effect of beta cyclodextrin on assay of glipizide tablets. ... Hence there is a chance of interaction of cyclodextrin with glipizide and it depends on the selected analytical technique. ...
Beta Cyclodextrin Derivatives as Protein Aggregation Modulators. by Carmen Popescu, Miles Larson, Nathan Ma, Shiqi Hong and ... ß-cyclodextrin, with MS=0.65) and (KLEPTOSE® HP hydroxypropyl-ß-cyclodextrin, with MS=0.9) on two biologic drugs (Infliximab ... Preliminary results demonstrate that KLEPTOSE® HPB BioPharma hydroxypropyl-ß-cyclodextrin and KLEPTOSE® HP BioPharma ... hydroxypropyl-ß-cyclodextrin at high molarity (200 mM) are efficient tools in modulating Infliximab relative degree of ...
GLOBAL FOLD OF MALTODEXTRIN BINDING PROTEIN COMPLEXED WITH BETA-CYCLODEXTRIN USING PEPTIDE ORIENTATIONS FROM DIPOLAR COUPLINGS ... Maltose-binding periplasmic protein, Beta-lactamase TEM chimera SEE REMARK 999 562 3.5.2.6 , Details ... Maltose-binding periplasmic protein, Beta-lactamase TEM chimera SEE REMARK 999 562 3.5.2.6 , Details ...
X-ray structure of the mutant E354A complexed with beta-cyclodextrin, and kinetic analyses on cyclodextrins. ... Studies on the hydrolyzing mechanism for cyclodextrins of Thermoactinomyces vulgaris R-47 alpha-amylase 2 (TVAII). ... Alpha Beta Alpha-Beta Barrel TIM Barrel Glycosidases A4. 1g1yA04. Mainly Beta Sandwich Immunoglobulin-like Golgi alpha- ... Alpha Beta Alpha-Beta Barrel TIM Barrel Glycosidases B4. 1g1yB04. Mainly Beta Sandwich Immunoglobulin-like Golgi alpha- ...
We also Provide Trading Suppliers & Manufacture for 117194-77-1 3A-AMINO-3A-DEOXY-(2AS,3AS)-BETA-CYCLODEXTRIN. ... BETA-CYCLODEXTRIN. *Synonyms: 3A-AMINO-3A-DEOXY-(2AS,3AS)-BETA-CYCLODEXTRIN;3A-Amino-3A-deoxy-(2AS,3AS)-beta-cyclodextrin ... 3A-AMINO-3A-DEOXY-(2AS,3AS)-BETA-CYCLODEXTRIN. Cas No: 117194-77-1. No Data. No Data. No Data. Skyrun Industrial Co.,Ltd. ... 3A-AMino-3A-deoxy-(2AS,3AS)-beta-cyclodextrin Hydrate. Cas No: 117194-77-1. No Data. No Data. No Data. Antimex Chemical Limied ...
Simultaneous determination of flavonoid analogs in Scutellariae Barbatea Herba by beta-cyclodextrin and acetonitrile modified ... Simultaneous determination of flavonoid analogs in Scutellariae Barbatea Herba by beta-cyclodextrin and acetonitrile modified ...
Beta cyclodextrins bind and remove Lipofuscin Bisretinoids from RPE You will receive an email whenever this article is ... Marcelo Nociari; Beta cyclodextrins bind and remove Lipofuscin Bisretinoids from RPE. Invest. Ophthalmol. Vis. Sci. 2013;54(15 ... Results: We have identified beta cyclodextrins (β-CDs), cyclic rings formed by 7 glucose residues, as small drugs that bind A2E ... We show that treatment with beta-CDs stabilizes A2E by preventing its oxidation, and reduces bisretinoid content from ...
Peter Sun, FDA, HPBCD, hydroxyl-propyl-beta-cyclodextrin, identical twins, Johnson & Johnson, Lorenzos Oil, Medtronic, ... You are here: Home / Archives for hydroxyl-propyl-beta-cyclodextrin. FDA Filing Made Requesting Use of Medtronic SynchroMed ... with the FDA yesterday on behalf of the twins seeking a permanent solution to deliver hydroxyl-propyl-beta-cyclodextrin [...] ... Weve reached another historic milestone in our effort to treat Addi and Cassi with cyclodextrin! Dr. Caroline Hastings at ...
Molecular Recognition by beta-Cyclodextrin Derivatives: FEP vs MM / PBSA Study. Author(s): I. Bea, E. cervello, P. A. Kollman, ... p-tert-butylbenzamide and a bisadamantyl-phosphate derivative with a beta-cyclodextrin derivative formed by two cyclodextrin ... p-tert-butylbenzamide and a bisadamantyl-phosphate derivative with a beta-cyclodextrin derivative formed by two cyclodextrin ... I. Bea, E. cervello, P. A. Kollman and C. jaime, " Molecular Recognition by beta-Cyclodextrin Derivatives: FEP vs MM / PBSA ...
Crystal structure of the 1:1 complex of heptakis (2,3,6-tri-O-methyl)cyclomalto-heptaose(permethylated beta-cyclodextrin)with ...
Beta-cyclodextrin (beta-CD) is an ideal candidate for a host molecule, and it is used as such in drug delivery and separation ... Insight into the Structural Deformations of Beta-Cyclodextrin Caused by Alcohol Cosolvents and Guest Molecules. Zhang, Haiyang ... Interaction with puerarin endowed beta-CD with a more rigid structure than with daidzin and a weaker ternary complex beta-CD/ ... The structural behavior of free beta-CD and host guest complexes of beta-CD with two isoflavonoid isomers (puerarin and daidzin ...
... K-REx Repository. Search K-REx. This Collection. ... Beta-cyclodextrin complexing to reduce antibiotic residue in milk. Banala, S.; Brouk, Michael J.; Simmons, S.R.; Schmidt, Karen ... cyclodextrin (β-CD) were added to water or pasteurized whole milk to study β-CD crystallization patterns. Influential factors ... Keywords: Dairy; β-cyclodextrin; Cephapirin; Sodium; Cephapirin benzathine; Milk. Conference: Dairy Day, 2004, Kansas State ...
Cyclodextrins (CD) and calixarenes are complexing agents that have been successfully used as pharmaceutical drug carriers, to ... Investigation of tetracaine complexation with beta-cyclodextrins and p-sulphonic acid calix[6]arenes by nOe and PGSE NMR ... Inclusion compounds between beta-cyclodextrin: local anesthetics a theoretical and experimental study using differential ... Inclusion complex of piroxicam with beta-cyclodextrin and incorporation in cationic microemulsion. In vitro drug release and in ...
"Methyl-beta cyclodextrin alters the production and infectivity of Sendai virus, Archives of Virology" on DeepDyve, the largest ... Methyl-beta cyclodextrin alters the production and infectivity of Sendai virus. Methyl-beta cyclodextrin alters the production ... Methyl-beta cyclodextrin alters the production and infectivity of Sendai virus. Fujita, Hiroshi; Tamai, Katsuto; Kawachi, ... Differential effects of alpha-, beta- and gamma-cyclodextrins on human erythrocytes. Ohtani, Y; Irie, T; Uekama, K; Fukunaga, K ...
J David Warren - Beta cyclodextrins bind, stabilize, and remove lipofuscin bisretinoids from retinal pigment epithelium. ...
  • Appearance: White Power, sweet, insipid, innocent CAS NO.: 92517-02-7 Standards: In-house standard Durability: 36 months Product Description In the field of medicine Glucosyl-Beta-Cyclodextrin can be used to improve the effectiveness of synthetic technology of Chiral drugs. (cyclodextrinchina.com)
  • Appearance: White Power, sweet, insipid, innocent CAS NO.: 92517-02-7 Standards: In-house standard Application:Food, Pharmaceuticals, Cosmetics Durability: 36 months In the fields of food and spice Glucosyl beta cyclodextrin can improve the stability and long effect of. (cyclodextrinchina.com)
  • Beta-cyclodextrins ( β -cds) are particularly efficient sterol acceptors, apparently because the size of their inner hydrophobic cavity matches the size of the sterol molecule (18, 28, 30, 34). (scielo.br)
  • Description Beta cyclodextrin is a cyclic heptamer composed of seven glucose units joined head to tail by alpha 1 4 links It is produced by the action of the enzyme cyclodextrin glycosyl transferase CGT on hydrolyzed starch syrups And it is white powder and there is a cavity in its molecule which. (zhishangchemical.com)
  • Characteristics and Uses: The introduction of hydroxypropyl β - cyclodextrin breaking intramolecular hydrogen bond ring, while maintaining the cyclodextrin cavity while overcoming the poorly water-soluble β - cyclodextrin major drawback. (infospaceinc.com)
  • NMR experiments revealed changes in the chemical shift of H3HP-β-CD hydrogens (δ=0.026ppm) that were compatible with the insertion of CND in the hydrophobic cavity of the cyclodextrin. (conicet.gov.ar)
  • Concerning the structure of the complex, a Cl-in orientation of pyrimethamine in the 2-hydroxypropyl-o-cyclodextrin cavity has been proposed from the theoretical calculations, being confirmed by two-dimensional H-1 NMR spectroscopy (ROESY). (unicamp.br)
  • Beta Cyclodextrin a sugar polymer which is used in pharmaceuticals food and cosmetics in many form to make a novel drug delivery systems to make an drug readily absorbable by making a drug otherwise poor soluble in to a freely soluble drug in biological membranes. (pharmacistspharmajournal.org)
  • α-Cyclodextrin is a soluble dietary fiber used as an ingredient in commercial food products. (wikipedia.org)
  • Preliminary results demonstrate that KLEPTOSE® HPB BioPharma hydroxypropyl-ß-cyclodextrin and KLEPTOSE® HP BioPharma hydroxypropyl-ß-cyclodextrin at high molarity (200 mM) are efficient tools in modulating Infliximab relative degree of aggregation. (bioprocessintl.com)
  • Roquette has pioneered the development of betacyclodextrin technology, developing a full range of KLEPTOSE ® betacyclodextrins and has extended it to pea maltodextrins with KLEPTOSE ® Linecaps. (roquette.com)
  • The wide KLEPTOSE ® range of betacyclodextrins (native and modified) is designed to address your different dosage forms (liquids, solids, semi solids), to adapt to your different processes (kneading, extrusion, spray drying, lyophilisation, milling/grinding) and constraints (factors affecting drug stability). (roquette.com)
  • Cyclodextrins are cyclic oligosaccharides composed of six to eight units of glucopyranosyl connected by α-(1→4) linkages ( Davis and Brewster, 2004 ). (frontiersin.org)
  • The largest cyclodextrin contains 32 1,4-anhydroglucopyranoside units, while as a poorly characterized mixture, at least 150-membered cyclic oligosaccharides are also known. (wikipedia.org)
  • Present investigation was conducted to examine the chemical renal carcinogenesis using N-ethyl-N-hydroxyethylnitrosamine (EHEN) as a initiator and beta-cyclodextrin (beta-C) as a promoter in dogs. (nii.ac.jp)
  • In this study, we report that beta cyclodextrins, cyclic sugars composed of seven glucose units, can bind retinal lipofuscin, prevent its oxidation and remove it from RPE. (pnas.org)
  • CYCLODEXTRIN First draft prepared by Ms F D Pollitt Health Aspects of the Environment and Food (Medical) Division Department of Health London, England Explanation Biological data Toxicological studies Short-term toxicity studies Long-term toxicity/carcinogenicity studies Reproductive toxicity studies Special studies on interactions with bile acids and lipophilic nutrients Comments Evaluation References 1. (inchem.org)
  • Cyclodextrins have been used as tools to manipulate the lipid composition of biological and model membranes (29). (scielo.br)
  • Proportions have not for directly online een coupon is doxycycline with beta cyclodextrin divalent tootake powder-free drive death some translational fake area doxycycline disease drug proposition. (gitegrangesdelie.com)
  • Cyclodextrins are also used to produce alcohol powder by encapsulating ethanol. (wikipedia.org)
  • The beta form will cover a broad range of molecule sizes. (sigmaaldrich.com)
  • In the food industry, cyclodextrins are employed for the preparation of cholesterol free products: the bulky and hydrophobic cholesterol molecule is easily lodged inside cyclodextrin rings that are then removed. (wikipedia.org)
  • The strong ability of complexing fragrances can also be used for another purpose: first dry, solid cyclodextrin microparticles are exposed to a controlled contact with fumes of active compounds, then they are added to fabric or paper products. (wikipedia.org)
  • The hydroxypropyl-β-cyclodextrin-polyvinylpyrrolidone-loaded resveratrol electrospinning nanofibers were characterized with scanning electron microscopy, Fourier-transform infrared spectroscopy, Raman spectroscopy, differential scanning calorimetry, and ultraviolet irradiation test. (ijpsonline.com)
  • Results obtained indicated successful encapsulation of resveratrol in hydroxypropyl-β-cyclodextrin- polyvinylpyrrolidone nanofibers, the diameter of the fiber could reach nanoscale and resveratrol existed in an amorphous state. (ijpsonline.com)
  • Intrathecal 2-hydroxypropyl-beta-cyclodextrin (HPbetaCD, VTS-270) has proven effective in reducing signs and prolonging life in NPC1 animal models, and Phase 1/2a data support efficacy in NPC1 patients. (clinicaltrials.gov)
  • We are currently looking at different ways to get cyclodextrin into the body - possibly through regular subcutaneous injections as well as intrathecal methods to get cyclodextrin directly into the brain through the spinal canal. (addiandcassi.com)
  • Cyclodextrins are composed of 5 or more α-D-glucopyranoside units linked 1->4, as in amylose (a fragment of starch). (wikipedia.org)
  • Category 4, 5 are the research frontiers of supramolecular chemistry.Category 1,2,3 as new materials that have hydrophilic and molecular complexablity by introducing cyclodextrins to traditional ploymers have great future: First, one application is in the establishment of economic separation system, such as membrane based on cyclodextrin. (zycydextrin.com)
  • Third, cyclodextrin modified natural or synthetic fibers show significant improvements in hydrophilic and electrostatic properties. (zycydextrin.com)