Beta cyclodextrins. Medical search

A homologous group of cyclic GLUCANS consisting of alpha-1,4 bound glucose units obtained by the action of cyclodextrin glucanotransferase on starch or similar substrates. The enzyme is produced by certain species of Bacillus. Cyclodextrins form inclusion complexes with a wide variety of substances.

Cyclic GLUCANS consisting of six (6) glucopyranose units linked by 1,4-glycosidic bonds.

Cyclic GLUCANS consisting of seven (7) glucopyranose units linked by 1,4-glycosidic bonds.

Cyclic GLUCANS consisting of eight (8) glucopyranose units linked by 1,4-glycosidic bonds.

A phenothiazine derivative that is used as an antipruritic.

Complex compounds in which a dumbbell shaped molecule is encircled by a macrocycle. They are named after rota (wheel) and axis (axle). Notation with a prefix is used to indicate the number of interlocked components. They have potential use in NANOTECHNOLOGY. Rotaxanes have been made with CYCLODEXTRINS and CYCLIC ETHERS.

The ability of a substance to be dissolved, i.e. to form a solution with another substance. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)

Any of a group of polysaccharides of the general formula (C6-H10-O5)n, composed of a long-chain polymer of glucose in the form of amylose and amylopectin. It is the chief storage form of energy reserve (carbohydrates) in plants.

Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use.

A family of gram-positive, saprophytic bacteria occurring in soil and aquatic environments.

The rotation of linearly polarized light as it passes through various media.

A measure of relative protection provided by SUNSCREENING AGENTS against burns due to ultraviolet (UV) radiation from a light source.

Enzymes that catalyze the endohydrolysis of 1,4-alpha-glycosidic linkages in STARCH; GLYCOGEN; and related POLYSACCHARIDES and OLIGOSACCHARIDES containing 3 or more 1,4-alpha-linked D-glucose units.

Salts and esters of the 14-carbon saturated monocarboxylic acid--myristic acid.

An enzyme that catalyzes the hydrolysis of terminal 1,4-linked alpha-D-glucose residues successively from non-reducing ends of polysaccharide chains with the release of beta-glucose. It is also able to hydrolyze 1,6-alpha-glucosidic bonds when the next bond in sequence is 1,4.

The chemical and physical integrity of a pharmaceutical product.

Enzymes that catalyze the transfer of glucose from a nucleoside diphosphate glucose to an acceptor molecule which is frequently another carbohydrate. EC 2.4.1.-.

An inhibitor of ALPHA-GLUCOSIDASES that retards the digestion and absorption of DIETARY CARBOHYDRATES in the SMALL INTESTINE.

An interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein. Proteolytic processing of the precursor form by CASPASE 1 results in release of the active form of interleukin-1beta from the membrane.

Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.

The homogeneous mixtures formed by the mixing of a solid, liquid, or gaseous substance (solute) with a liquid (the solvent), from which the dissolved substances can be recovered by physical processes. (From Grant & Hackh's Chemical Dictionary, 5th ed)

The thermodynamic interaction between a substance and WATER.

The preparation, mixing, and assembling of a drug. (From Remington, The Science and Practice of Pharmacy, 19th ed, p1814)

A mass spectrometric technique that is used for the analysis of a wide range of biomolecules, such as glycoalkaloids, glycoproteins, polysaccharides, and peptides. Positive and negative fast atom bombardment spectra are recorded on a mass spectrometer fitted with an atom gun with xenon as the customary beam. The mass spectra obtained contain molecular weight recognition as well as sequence information.

Differential thermal analysis in which the sample compartment of the apparatus is a differential calorimeter, allowing an exact measure of the heat of transition independent of the specific heat, thermal conductivity, and other variables of the sample.

Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).

An 11-kDa protein associated with the outer membrane of many cells including lymphocytes. It is the small subunit of the MHC class I molecule. Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. Beta 2-microglobulin is present in small amounts in serum, csf, and urine of normal people, and to a much greater degree in the urine and plasma of patients with tubular proteinemia, renal failure, or kidney transplants.

A genus of BACILLACEAE that are spore-forming, rod-shaped cells. Most species are saprophytic soil forms with only a few species being pathogenic.

Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.

Volunteer organizations whose members perform work for the hospital without compensation.

Personnel whose work is prescribed and supervised by the dentist.

Substances intended to be applied to the human body for cleansing, beautifying, promoting attractiveness, or altering the appearance without affecting the body's structure or functions. Included in this definition are skin creams, lotions, perfumes, lipsticks, fingernail polishes, eye and facial makeup preparations, permanent waves, hair colors, toothpastes, and deodorants, as well as any material intended for use as a component of a cosmetic product. (U.S. Food & Drug Administration Center for Food Safety & Applied Nutrition Office of Cosmetics Fact Sheet (web page) Feb 1995)

Drugs manufactured and sold with the intent to misrepresent its origin, authenticity, chemical composition, and or efficacy. Counterfeit drugs may contain inappropriate quantities of ingredients not listed on the label or package. In order to further deceive the consumer, the packaging, container, or labeling, may be inaccurate, incorrect, or fake.

Exploitation through misrepresentation of the facts or concealment of the purposes of the exploiter.

A cellulose derivative which is a beta-(1,4)-D-glucopyranose polymer. It is used as a bulk laxative and as an emulsifier and thickener in cosmetics and pharmaceuticals and as a stabilizer for reagents.

Completed forms of the pharmaceutical preparation in which prescribed doses of medication are included. They are designed to resist action by gastric fluids, prevent vomiting and nausea, reduce or alleviate the undesirable taste and smells associated with oral administration, achieve a high concentration of drug at target site, or produce a delayed or long-acting drug effect.

A mobile, very volatile, highly flammable liquid used as an inhalation anesthetic and as a solvent for waxes, fats, oils, perfumes, alkaloids, and gums. It is mildly irritating to skin and mucous membranes.

A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic for cancer chemotherapy patients.

The branch of pharmacology that deals directly with the effectiveness and safety of drugs in humans.

The study of the origin, nature, properties, and actions of drugs and their effects on living organisms.

Procedures concerned with the remedial treatment or prevention of diseases.

Societies whose membership is limited to pharmacists.

A family of 6-membered heterocyclic compounds occurring in nature in a wide variety of forms. They include several nucleic acid constituents (CYTOSINE; THYMINE; and URACIL) and form the basic structure of the barbiturates.

A genus of gram-positive bacteria in the family Thermoactinomycetaceae, that can cause FARMER'S LUNG.

A form of alveolitis or pneumonitis due to an acquired hypersensitivity to inhaled antigens associated with farm environment. Antigens in the farm dust are commonly from bacteria actinomycetes (SACCHAROPOLYSPORA and THERMOACTINOMYCES), fungi, and animal proteins in the soil, straw, crops, pelts, serum, and excreta.

An order of gram-positive, primarily aerobic BACTERIA that tend to form branching filaments.

A naturally occurring lipid pigment with histochemical characteristics similar to ceroid. It accumulates in various normal tissues and apparently increases in quantity with age.

The single layer of pigment-containing epithelial cells in the RETINA, situated closely to the tips (outer segments) of the RETINAL PHOTORECEPTOR CELLS. These epithelial cells are macroglia that perform essential functions for the photoreceptor cells, such as in nutrient transport, phagocytosis of the shed photoreceptor membranes, and ensuring retinal attachment.

A group of tetraterpenes, with four terpene units joined head-to-tail. Biologically active members of this class are used clinically in the treatment of severe cystic ACNE; PSORIASIS; and other disorders of keratinization.

A retrogressive pathological change in the retina, focal or generalized, caused by genetic defects, inflammation, trauma, vascular disease, or aging. Degeneration affecting predominantly the macula lutea of the retina is MACULAR DEGENERATION. (Newell, Ophthalmology: Principles and Concepts, 7th ed, p304)

The layer of pigment-containing epithelial cells in the RETINA; the CILIARY BODY; and the IRIS in the eye.

Degenerative changes in the RETINA usually of older adults which results in a loss of vision in the center of the visual field (the MACULA LUTEA) because of damage to the retina. It occurs in dry and wet forms.

Opposite behavior of two isozymes when refolding in the presence of non-ionic detergents. (1/1074)

GroEL has a greater affinity for the mitochondrial isozyme (mAAT) of aspartate aminotransferase than for its cytosolic counterpart (cAAT) (Mattingly JR Jr, Iriarte A, Martinez-Carrion M, 1995, J Biol Chem 270:1138-1148), two proteins that share a high degree of sequence similarity and an almost identical spatial structure. The effect of detergents on the refolding of these large, dimeric isozymes parallels this difference in behavior. The presence of non-ionic detergents such as Triton X-100 or lubrol at concentrations above their critical micelle concentration (CMC) interferes with reactivation of mAAT unfolded in guanidinium chloride but increases the yield of cAAT refolding at low temperatures. The inhibitory effect of detergents on the reactivation of mAAT decreases progressively as the addition of detergents is delayed after starting the refolding reaction. The rate of disappearance of the species with affinity for binding detergents coincides with the slowest of the two rate-limiting steps detected in the refolding pathway of mAAT. Limited proteolysis studies indicate that the overall structure of the detergent-bound mAAT resembles that of the protein in a complex with GroEL. The mAAT folding intermediates trapped in the presence of detergents can resume reactivation either upon dilution of the detergent below its CMC or by adding beta-cyclodextrin. Thus, isolation of otherwise transient productive folding intermediates for further characterization is possible through the use of detergents. (+info)

Antilithiasic effect of beta-cyclodextrin in LPN hamster: comparison with cholestyramine. (2/1074)

Beta-Cyclodextrin (BCD), a cyclic oligosaccharide that binds cholesterol and bile acids in vitro, has been previously shown to be an effective plasma cholesterol lowering agent in hamsters and domestic pigs. This study examined the effects of BCD as compared with cholestyramine on cholesterol and bile acid metabolism in the LPN hamster model model for cholesterol gallstones. The incidence of cholesterol gallstones was 65% in LPN hamsters fed the lithogenic diet, but decreased linearly with increasing amounts of BCD in the diet to be nil at a dose of 10% BCD. In gallbladder bile, cholesterol, phospholipid and chenodeoxycholate concentrations, hydrophobic and lithogenic indices were all significantly decreased by 10% BCD. Increases in bile acid synthesis (+110%), sterol 27-hydroxylase activity (+106%), and biliary cholate secretion (+140%) were also observed, whereas the biliary secretion of chenodeoxycholate decreased (-43%). The fecal output of chenodeoxycholate and cholate (plus derivatives) was increased by +147 and +64%, respectively, suggesting that BCD reduced the chenodeoxycholate intestinal absorption preferentially. Dietary cholestyramine decreased biliary bile acid concentration and secretion, but dramatically increased the fecal excretion of chenodeoxycholate and cholate plus their derivatives (+328 and +1940%, respectively). In contrast to BCD, the resin increased the lithogenic index in bile, induced black gallstones in 34% of hamsters, and stimulated markedly the activities of HMG-CoA reductase (+670%), sterol 27-hydroxylase (+310%), and cholesterol 7alpha-hydroxylase (+390%). Thus, beta-cyclodextrin (BCD) prevented cholesterol gallstone formation by decreasing specifically the reabsorption of chenodeoxycholate, stimulating its biosynthesis and favoring its fecal elimination. BCD had a milder effect on lipid metabolism than cholestyramine and does not predispose animals to black gallstones as cholestyramine does in this animal model. (+info)

Extraction of cholesterol with methyl-beta-cyclodextrin perturbs formation of clathrin-coated endocytic vesicles. (3/1074)

The importance of cholesterol for endocytosis has been investigated in HEp-2 and other cell lines by using methyl-beta-cyclodextrin (MbetaCD) to selectively extract cholesterol from the plasma membrane. MbetaCD treatment strongly inhibited endocytosis of transferrin and EGF, whereas endocytosis of ricin was less affected. The inhibition of transferrin endocytosis was completely reversible. On removal of MbetaCD it was restored by continued incubation of the cells even in serum-free medium. The recovery in serum-free medium was inhibited by addition of lovastatin, which prevents cholesterol synthesis, but endocytosis recovered when a water-soluble form of cholesterol was added together with lovastatin. Electron microscopical studies of MbetaCD-treated HEp-2 cells revealed that typical invaginated caveolae were no longer present. Moreover, the invagination of clathrin-coated pits was strongly inhibited, resulting in accumulation of shallow coated pits. Quantitative immunogold labeling showed that transferrin receptors were concentrated in coated pits to the same degree (approximately sevenfold) after MbetaCD treatment as in control cells. Our results therefore indicate that although clathrin-independent (and caveolae-independent) endocytosis still operates after removal of cholesterol, cholesterol is essential for the formation of clathrin-coated endocytic vesicles. (+info)

Cellular cholesterol regulates expression of the macrophage type B scavenger receptor, CD36. (4/1074)

CD36, the macrophage type B scavenger receptor, binds and internalizes oxidized low density lipoprotein (OxLDL), and may potentially play a role in the development of atherosclerosis. We reported that the native and modified low density lipoproteins increased CD36 mRNA and protein ( J. Biol. Chem. 272: 21654-21659). In this study, we investigated the effect of alterations of cellular cholesterol content on macrophage expression of CD36. Depletion of cholesterol by treatment with beta-cyclodextrins (beta-cyclodextrin [beta-CD] and methylated beta-cyclodextrin [MebetaCD]) significantly decreased CD36 mRNA and 125I-labeled OxLDL binding. Conversely, loading macrophages with cholesterol or cholesteryl ester (acetate) with MebetaCD:cholesterol complexes increased CD36 mRNA, 125I-labeled OxLDL binding, and CD36 surface expression as determined by fluorescence activated cell sorting. Thus, CD36 expression paralleled cellular cholesterol levels after removal of cholesterol with beta-cyclodextrins or addition of cholesterol with MebetaCD:cholesterol complexes. Neither cholesterol depletion nor loading altered expression of type A scavenger receptor mRNA. Kinetics studies showed that changes in CD36 mRNA occurred after changes of cellular cholesterol. Neither beta-cyclodextrins nor MebetaCD:cholesterol altered CD36 mRNA half-life in the presence of actinomycin D, suggesting that alterations in CD36 expression by cholesterol occur at the transcriptional level. These experiments demonstrate that CD36 expression is enhanced by cholesterol and down-regulated by cholesterol efflux, and imply that macrophage expression of CD36 and foam cell formation in atherosclerotic lesions may be perpetuated by a cycle in which lipids drive expression of CD36 in a self-regulatory manner. (+info)

Critical role for cholesterol in Lyn-mediated tyrosine phosphorylation of FcepsilonRI and their association with detergent-resistant membranes. (5/1074)

Tyrosine phosphorylation of the high affinity immunoglobulin (Ig)E receptor (FcepsilonRI) by the Src family kinase Lyn is the first known biochemical step that occurs during activation of mast cells and basophils after cross-linking of FcepsilonRI by antigen. The hypothesis that specialized regions in the plasma membrane, enriched in sphingolipids and cholesterol, facilitate the coupling of Lyn and FcepsilonRI was tested by investigating functional and structural effects of cholesterol depletion on Lyn/FcepsilonRI interactions. We find that cholesterol depletion with methyl-beta-cyclodextrin substantially reduces stimulated tyrosine phosphorylation of FcepsilonRI and other proteins while enhancing more downstream events that lead to stimulated exocytosis. In parallel to its inhibition of tyrosine phosphorylation, cholesterol depletion disrupts the interactions of aggregated FcepsilonRI and Lyn on intact cells and also disrupts those interactions with detergent-resistant membranes that are isolated by sucrose gradient ultracentrifugation of lysed cells. Importantly, cholesterol repletion restores receptor phosphorylation together with the structural interactions. These results provide strong evidence that membrane structure, maintained by cholesterol, plays a critical role in the initiation of FcepsilonRI signaling. (+info)

Sweet taste responses of mouse chorda tympani neurons: existence of gurmarin-sensitive and -insensitive receptor components. (6/1074)

Inhibitory effects of gurmarin (gur) on responses to sucrose and other sweeteners of single fibers of the chorda tympani nerve in C57BL mice were examined. Of 30 single fibers that strongly responded to 0. 5 M sucrose but were not or to lesser extent responsive to 0.1 M NaCl, 0.01 M HCl, and 0.02 M quinine HCl (sucrose-best fibers), 16 fibers showed large suppression of responses to sucrose and other sweeteners by lingual treatment with 4.8 microM (approximately 20 microg/ml) gur (suppressed to 4-52% of control: gur-sensitive fibers), whereas the remaining 14 fibers showed no such gur inhibition (77-106% of control: gur-insensitive fibers). In gur-sensitive fibers, responses to sucrose inhibited by gur recovered to approximately 70% of control responses after rinsing the tongue with 15 mM beta-cyclodextrin and were almost abolished by further treatment with 2% pronase. In gur-insensitive fibers, sucrose responses were not inhibited by gur, but were largely suppressed by pronase. These results suggest existence of two different receptor components for sweeteners with different susceptibilities to gur in mouse taste cells, one gur sensitive and the other gur insensitive. Taste cells possessing each component may be specifically innervated by a particular type of chorda tympani neurons. (+info)

Intracellular phosphotyrosine induction by major histocompatibility complex class II requires co-aggregation with membrane rafts. (7/1074)

Cross-linking MHC class II molecules human leukocyte antigen (HLA-DR) on the surface of THP-1 cells was found to induce their entry into the glycolipid-enriched membrane fraction of the plasma membrane. At the cellular level, this resulted in the synergistic co-aggregation of class II with cholera toxin, a marker of membrane rafts. The accompanying induction of intracellular protein tyrosine phosphorylation could be inhibited by treating cells with methyl-beta-cyclodextrin, a drug that chelates membrane cholesterol and thereby disperses membrane rafts. Signaling could also be inhibited by treating cells with the Src-family kinase inhibitor PP1. Together, these results show that the induced association of class II molecules with membrane rafts can contribute to their aggregation on the cell surface and mediate an association with intracellular protein-tyrosine kinases. (+info)

Comparison of the capacity of beta-cyclodextrin derivatives and cyclophanes to shuttle cholesterol between cells and serum lipoproteins. (8/1074)

Previous studies from this laboratory have demonstrated that low concentrations of cyclodextrins (<1.0 mm), when added to serum, act catalytically as cholesterol shuttles to accelerate the exchange of free cholesterol between cells and serum lipoproteins. As cholesterol shuttles, cyclodextrins have the potential to serve as pharmacological agents for modifying cholesterol metabolism. In the present study, we have quantitated the cholesterol-shuttling capacity of a series of newly synthesized beta-cyclodextrin derivatives (betaCDs), with varying structure, and two double-decker cyclophanes. The general protocol is as follows. [(3)H]cholesterol-labeled CHOK1 cells are incubated for 2 h with the test compounds alone or together with 5% human serum, and efflux of the cellular [(3)H]cholesterol is measured. As methyl beta-cyclodextrin (MbetaCD) served as the basis for comparison, initial experiments were conducted that demonstrated there was a dose-dependent stimulation of cell cholesterol efflux as the concentration of MbetaCD increased, with an EC(50) that was calculated to be 0.05 mm. To determine the cholesterol-shuttling capacity of the newly synthesized compounds, cell cholesterol efflux is measured when the compounds are present alone, at a concentration of 0.05 mm, or together with 5% human serum. Our results demonstrate that the double-decker cyclophanes are the most efficient cholesterol shuttles. Under our experimental conditions, methyl beta-cyclodextrin (MbetaCD) approximately doubles the efflux of cell cholesterol to serum, whereas one of the double-decker cyclophanes produces a 4-fold stimulation in efflux. Four of the beta-cyclodextrin derivatives (betaCDs) display shuttling ability similar to that of MbetaCD. Furthermore, there does not appear to be a structural pattern among the other betaCDs which could explain their shuttling capacity. (+info)

The active ingredient in the root was synthesized and encapsulated with beta-cyclodextrins. The roots were also subjected to ...

https://en.wikipedia.org/wiki/Decalepis_hamiltonii

developed a catalyst based on a beta-cyclodextrin carrying two imidazole groups. This cyclodextrin catalytic system mimics ... Cyclodextrins have rigid ring structure, hydrophilic surface, and hydrophobic cavity on the inside; therefore, they are capable ... From the early 1970s, cyclodextrins have been extensively studied for its encapsulation properties and used as binding sites in ... Self-assembled molecules have an advantage over crown ether and cyclodextrin in that they can capture significant larger ...

https://en.wikipedia.org/wiki/Supramolecular_catalysis

... beta.-cyclodextrin". Journal of the American Chemical Society. 105 (5): 1390-91. doi:10.1021/ja00343a063. "Anthony W. Czarnik, ...

https://en.wikipedia.org/wiki/Anthony_Czarnik

"Synthesis and inclusion ability of a bis-beta-cyclodextrin pseudo-cryptand towards Busulfan anticancer agent". Tetrahedron. 63 ... Porwanski S, Florence DC, Menuel S, Joly JP, Bulach V, Marsura A (2009). "Bis-beta-cyclodextrinyl- and bis-cellobiosyl- ... The molecular recognition of ureido-cyclodextrin with busulfan was investigated. The formation of complexes was observed with ...

https://en.wikipedia.org/wiki/Busulfan

Only unbound maropitant causes pain - it is normally formulated with beta-cyclodextrin to increase solubility; at cooler ... temperatures, more of the maropitant remains bound to the cyclodextrin, leaving less maropitant unbound. While there is no pain ...

https://en.wikipedia.org/wiki/Maropitant

... with dimethyl-beta-cyclodextrin". Chem. Pharm. Bull. 45 (2): 378-83. doi:10.1248/cpb.45.378. PMID 9118452. Soell M, Feki A, ...

https://en.wikipedia.org/wiki/Saliva_testing

Hurley, JC; Volz, SA; Johnston, JJ (1999). "Stabilization of the avicide 3-chloro-p-toluidine as the beta-cyclodextrin adduct ...

https://en.wikipedia.org/wiki/Starlicide

Derived from this the derivatization of β-cyclodextrin to sulfobutyl ether-beta-cyclodextrin (SBECD) is by now an important ... Sulfobutyl ether-beta-cyclodextrin is a water-soluble inclusion compound for the solubilization and stabilization of sparsely ... Sulfobutyl ether-beta-cyclodextrin also finds a wide range of applications as an inert vehicle for drug delivery (the drugs ... "Evaluation of a sulfobutyl ether beta-cyclodextrin as a solubilizing/stabilizing agent for several drugs", Drug Dev. Ind. Pharm ...

https://en.wikipedia.org/wiki/1,4-Butane_sultone

The role of cholesterol in endocytosis of these types can be investigated by using methyl beta cyclodextrin (MβCD) to remove ...

https://en.wikipedia.org/wiki/Cholesterol

... cyclodextrins MeSH D09.698.365.855.400.375.222 - alpha-cyclodextrins MeSH D09.698.365.855.400.375.333 - beta-cyclodextrins MeSH ... beta-glucans MeSH D09.698.365.089.500 - lentinan MeSH D09.698.365.089.625 - sizofiran MeSH D09.698.365.089.750 - zymosan MeSH ... D09.698.365.855.400.375.444 - gamma-cyclodextrins MeSH D09.698.365.855.500 - hetastarch MeSH D09.698.365.855.750 - inulin MeSH ...

https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D09)

... which in turn consists of alternating subunits of beta-cyclodextrin and polyethylene glycol (PEG). The CRLX101 nanoparticle is ... The agent represents a nanoparticle conjugate that consists of a drug delivery molecule, namely a cyclodextrin-based polymer ( ... a cyclodextrin-containing polymer-camptothecin nanopharmaceutical in patients with advanced solid tumor malignancies". Invest. ...

https://en.wikipedia.org/wiki/CRLX101

At the moment, apiegnin and beta-cyclodextrin are thought to alleviate S.aureus pneumonia, whereas the antibodies of anti alpha ... Phospholipase C activity of purified beta-hemolysin". J. Bacteriol. 94 (5): 1313-9. doi:10.1128/JB.94.5.1313-1319.1967. PMC ... Compared to beta-hemolysin, it has a higher affinity for phosphocholines with short saturated acyl chains, especially if they ...

https://en.wikipedia.org/wiki/Hemolysin

... from serum with satisfactory yield and used Beta-cyclodextrin as a competitor to displace IgG from the matrix.[21] This largely ... "Salt-independent hydrophobic displacement chromatography for antibody purification using cyclodextrin as supermolecular ...

https://en.wikipedia.org/wiki/Chromatography

α-Cyclodextrin is a hexasaccharide derived from glucose. It is related to the β- (beta) and γ- (gamma) cyclodextrins, which ... All cyclodextrins are white, water-soluble solids with minimal toxicity. Cyclodextrins tend to bind other molecules in their ... Then cyclodextrin glycosyltransferase (CGTase) is added for enzymatic conversion. CGTases produce diverse cyclodextrins. The ... The exterior surface of cyclodextrins is somewhat hydrophilic whereas the interior core is hydrophobic. α-Cyclodextrin is ...

https://en.wikipedia.org/wiki/Alpha-Cyclodextrin

beta-cyclodextrin - emülgatör. *Lemongrass. ÇDüzenle. *Kamelya yağı/ Daha çok güney Çin'de pişirme yağı olarak kullanılır. ...

https://tr.m.wikipedia.org/wiki/Gıda_katkı_maddeleri_listesi

The role of cholesterol in such endocytosis can be investigated by using methyl beta cyclodextrin (MβCD) to remove cholesterol ...

https://si.wikipedia.org/wiki/කොලෙස්ටරෝල්

Cyclodextrin The cyclical dextrins are known as cyclodextrins. They are formed by enzymatic degradation of starch by certain ... Beta) Limit dextrin is the remaining polymer produced by enzymatic hydrolysis of amylopectin with beta amylase, which cannot ... bacteria, for example, Paenibacillus macerans (Bacillus macerans). Cyclodextrins have toroidal structures formed by 6-8 glucose ...

https://en.wikipedia.org/wiki/Dextrin

Cyclodextrin, which may be produced from starch by means of enzymatic conversion ... Beta glucan. *Disodium wheat germamido PEG-2-sulfosuccinate. *Fermented grain extract. *AMP-Isostearoyl ...

https://en.m.wikipedia.org/wiki/Shampoo

It is not known whether reduction of beta-amyloid is a feasible way of treating Alzheimer's, as an anti-beta-amyloid vaccine ... A formulation of imatinib with a cyclodextrin (Captisol) as a carrier to overcome the blood-brain barrier is also currently[ ... In July 1997, Novartis filed a new patent application in Switzerland on the beta crystalline form of imatinib mesylate (the ... The patent application claimed the final form of Gleevec (the beta crystalline form of imatinib mesylate). In 1993, during the ...

https://en.wikipedia.org/wiki/Imatinib

Water Molecule in Hydrophobic Surroundings: Structure of alpha-Cyclodextrin-Hexahydrate (C6H10O5)6·6H2O, Nature, 1972 Circular ... Nature 1993 Crystal structure of beta-D-cellotetraose hemihydrate with implications for the structure of cellulose II, Science ...

https://en.wikipedia.org/wiki/Wolfram_Saenger

C35H44O16 Bacteriocin Beauvericin beta-Hydroxy beta-methylbutyric acid beta-Hydroxybutyric acid Bicuculline Bilirubin ... α-Cyclodextrin Cyclodextrin glycosyltransferase Cyclooxygenase Cyclopamine Cyclopiazonic acid Cysteine Cystine Cytidine ...

https://en.wikipedia.org/wiki/List_of_biomolecules

Despite the -lol suffix, the drug is not a beta-blocker. Corvalol is so common in Eastern Europe that, in 1996, the Ministry of ... β-cyclodextrin, acesulfame potassium. Phenobarbital, one of the principal ingredients in Corvalol, is a DEA Schedule IV ...

https://en.wikipedia.org/wiki/Corvalol

Statiner, beta-blokkere og CoQ10[redigér , redigér wikikode]. CoQ10 og kolesterol stammer fra samme biokemiske proces (the ... Dog viser ingen studier til dato, om det vandopløselige CoQ10-ß-Cyclodextrin-kompleks når frem til relevante væv, og hvorledes ... Inhibition of coenzyme Q10-enzymes by clinically used adrenergic blockers of beta-receptors". Research communications in ... ß-Cyclodextrin-molekyler [17][34][35]. Zmitek[36] arbejder hen imod at gøre CoQ10 så vandopløseligt, at stoffet kan tilsættes ...

https://da.wikipedia.org/wiki/Coenzym_Q10

Apropos of the study of the hemostatic activity in prostatectomy of a new molecule: beta-naphthoquinone monosemicarbazone ( ... Complexes and Their Supramolecular Assemblies with β-Cyclodextrin". Inorg Chem. 43 (11): 3521-3527. doi:10.1021/ic0352250. PMID ...

https://en.wikipedia.org/wiki/List_of_chemical_compounds_with_unusual_names

Penicillin and related beta lactams work by inhibiting DD-transpeptidase enzyme that is required by bacteria to cross link ... Examples of enzymes identified to date include amylases, pullulanases, cyclodextrin glycosyltransferases, cellulases, xylanases ...

https://en.wikipedia.org/wiki/Natural_product

Stoddart, Sir Fraser (2013). "Selective isolation of gold facilitated by second-sphere coordination by α-cyclodextrin". Nature ... MIT TechTV beta, 55 min., 51 sec. Galvao, A. "Mind Your Own Business, Why sustainable operations must be everyone's chief ...

https://en.wikipedia.org/wiki/Sustainable_business

1 October 2010). "Cyclodextrin-complexed curcumin exhibits anti-inflammatory and antiproliferative activities superior to those ... where his team characterized the cytokines TNF-alpha and TNF-beta. Aggarwal was Chief of the Cytokine Research Section, ...

https://en.wikipedia.org/wiki/Bharat_Aggarwal

Cyclodextrin NP Solid tumours I Active Calando Pharmaceuticals NCT00689065 TD101 K6a (N171K mutation) Naked siRNA Pachyonychia ... Studies in cells and in mouse have shown that specifically targeting Amyloid beta-producing genes (e.g. BACE1 and APP) by RNAi ...

https://en.m.wikipedia.org/wiki/RNAi

... and complexation with cyclodextrins; among the latter, the complex with β-cyclodextrin has been found to have highly increased ... Inhibition by statins and beta blockers[edit]. CoQ10 shares a biosynthetic pathway with cholesterol. The synthesis of an ... Inhibition of coenzyme Q10-enzymes by clinically used adrenergic blockers of beta-receptors". Research Communications in ... "A Study on the Bioavailability of a Novel Sustained-Release Coenzyme Q10-β-Cyclodextrin Complex". Integrative Medicine. 9 (1). ...

https://en.wikipedia.org/wiki/Ubidecarenone

... beta _{pq}} , is defined as β p q = [ H p G q ] [ H ] p [ G ] q {\displaystyle \beta _{pq}={\frac {[H_{p}G_{q}]}{[H]^{p}[G]^{q ... and Molecular Dynamics of Cyclodextrins with a Non-ionic Surfactant". Journal of Physical Chemistry B. 111 (17): 4383-92. doi: ... T H = [ H ] + ∑ p β p q [ H ] p [ G ] q {\displaystyle T_{H}=[H]+\sum p\beta _{pq}[H]^{p}[G]^{q}} T G = [ G ] + ∑ q β p q [ H ... beta _{pq}[H]^{p}[G]^{q}} . The relationship between a species' concentration and the measured quantity is specific for the ...

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"Synthesis and inclusion ability of a bis-beta-cyclodextrin pseudo-cryptand towards Busulfan anticancer agent". Tetrahedron. 63 ... The molecular recognition of ureido-cyclodextrin with busulfan was investigated.[9] The formation of complexes was observed ... Porwanski S, Florence DC, Menuel S, Joly JP, Bulach V, Marsura A (2009). "Bis-beta-cyclodextrinyl- and bis-cellobiosyl- ...

https://en.m.wikipedia.org/wiki/Busulfan

Main article: Cyclodextrin. The cyclical dextrins are known as cyclodextrins. They are formed by enzymatic degradation of ... Beta) Limit dextrin is the remaining polymer produced by enzymatic hydrolysis of amylopectin with beta amylase, which cannot ... starch by certain bacteria, for example, Paenibacillus macerans (Bacillus macerans). Cyclodextrins have toroidal structures ...

https://en.m.wikipedia.org/wiki/Dextrin

Beta cyclodextrins bind and remove A2E from RPE. Marcelo M. Nociari, Guillermo L. Lehmann, Andres E. Perez Bay, Roxana A. Radu ... Beta cyclodextrins bind and remove A2E from RPE. Marcelo M. Nociari, Guillermo L. Lehmann, Andres E. Perez Bay, Roxana A. Radu ... Beta cyclodextrins bind, stabilize, and remove lipofuscin bisretinoids from retinal pigment epithelium. Marcelo M. Nociari, ... Here we report that a family of modified cyclic oligosaccharides, beta cyclodextrins (β-CDs), formed by seven d-glucose units, ...

http://www.pnas.org/content/111/14/E1402

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See Also: Toxicological Abbreviations Beta-Cyclodextrin (WHO Food Additives Series 32) beta-CYCLODEXTRIN (JECFA Evaluation) ... HRC (1994b). Beta-cyclodextrin: Toxicity to dogs by repeated dietary administration for 52 weeks. Unpublished report no. ROQ 3/ ... HRC (1994a). Beta-cyclodextrin: Toxicity to rats by dietary administration for 52 weeks. Unpublished report no. ROQ 4/931090 ... Pharmakon Europe (1994). Beta-cyclodextrin: Three generation oral (dietary administration) reproduction toxicity study in the ...

http://www.inchem.org/documents/jecfa/jecmono/v35je12.htm

See Also: Toxicological Abbreviations beta-Cyclodextrin (WHO Food Additives Series 35) beta-CYCLODEXTRIN (JECFA Evaluation) ... SEBESTY N, G. (1980) The acute LD50 values of beta-cyclodextrin in CFY rats, CFLP mice and mongrel dogs. Report of Chinoin ... SMITH, T.G., COX, R.A., BUIST, D.P., CROOK, D., HADLEY, J.C. & C. GOPINATH (1992) Beta-cyclodextrin toxicity to dogs by ... BUSCH, B., BIESEMEIER, J.A. & BECCI, P.J. (1985) Acute inhalation toxicity study of beta cyclodextrin in Sprague Dawley rats. ...

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Beta-cyclodextrins (β-cds) are particularly efficient sterol acceptors, apparently because the size of their inner hydrophobic ... Chlorhexidine (Cx) augmented with beta-cyclodextrin (β-cd) inclusion compounds, termed Cx:β-cd complexes, have been developed ... Hence, in order to reduce the toxicity caused by high concentrations of Cx, chlorhexidine:beta-cyclodextrin (Cx:β-cd) complexes ... 9. Cortés, M.E.; Sinisterra, R.D.; Ávila-Campos, M.J.; Tortamano, N.; Rocha, R.G. (2001). The chlorhexidine:beta-cyclodextrin ...

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... sulfobutylether-beta-cyclodextrin (SBECD). This paper summarizes all known data on SBECD pharmacokinetics and s … ... Review of the basic and clinical pharmacology of sulfobutylether-beta-cyclodextrin (SBECD) J Pharm Sci. 2010 Aug;99(8):3291-301 ... sulfobutylether-beta-cyclodextrin (SBECD). This paper summarizes all known data on SBECD pharmacokinetics and safety. In ... beta-Cyclodextrins / adverse effects * beta-Cyclodextrins / chemistry* * beta-Cyclodextrins / pharmacokinetics * beta- ...

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Since beta-cyclodextrin is. Answer: Since beta-cyclodextrin is complexed with glipizide for better dissolution, there is ... Pharmaceutical Information » Question Category » Pharma Industry » effect of beta cyclodextrin on assay of glipizide tablets. ... Hence there is a chance of interaction of cyclodextrin with glipizide and it depends on the selected analytical technique. ...

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Beta Cyclodextrin Derivatives as Protein Aggregation Modulators. by Carmen Popescu, Miles Larson, Nathan Ma, Shiqi Hong and ... ß-cyclodextrin, with MS=0.65) and (KLEPTOSE® HP hydroxypropyl-ß-cyclodextrin, with MS=0.9) on two biologic drugs (Infliximab ... Preliminary results demonstrate that KLEPTOSE® HPB BioPharma hydroxypropyl-ß-cyclodextrin and KLEPTOSE® HP BioPharma ... hydroxypropyl-ß-cyclodextrin at high molarity (200 mM) are efficient tools in modulating Infliximab relative degree of ...

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GLOBAL FOLD OF MALTODEXTRIN BINDING PROTEIN COMPLEXED WITH BETA-CYCLODEXTRIN USING PEPTIDE ORIENTATIONS FROM DIPOLAR COUPLINGS ... Maltose-binding periplasmic protein, Beta-lactamase TEM chimera SEE REMARK 999 562 3.5.2.6 , Details ... Maltose-binding periplasmic protein, Beta-lactamase TEM chimera SEE REMARK 999 562 3.5.2.6 , Details ...

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X-ray structure of the mutant E354A complexed with beta-cyclodextrin, and kinetic analyses on cyclodextrins. ... Studies on the hydrolyzing mechanism for cyclodextrins of Thermoactinomyces vulgaris R-47 alpha-amylase 2 (TVAII). ... Alpha Beta Alpha-Beta Barrel TIM Barrel Glycosidases A4. 1g1yA04. Mainly Beta Sandwich Immunoglobulin-like Golgi alpha- ... Alpha Beta Alpha-Beta Barrel TIM Barrel Glycosidases B4. 1g1yB04. Mainly Beta Sandwich Immunoglobulin-like Golgi alpha- ...

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Simultaneous determination of flavonoid analogs in Scutellariae Barbatea Herba by beta-cyclodextrin and acetonitrile modified ... Simultaneous determination of flavonoid analogs in Scutellariae Barbatea Herba by beta-cyclodextrin and acetonitrile modified ...

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Beta cyclodextrins bind and remove Lipofuscin Bisretinoids from RPE You will receive an email whenever this article is ... Marcelo Nociari; Beta cyclodextrins bind and remove Lipofuscin Bisretinoids from RPE. Invest. Ophthalmol. Vis. Sci. 2013;54(15 ... Results: We have identified beta cyclodextrins (β-CDs), cyclic rings formed by 7 glucose residues, as small drugs that bind A2E ... We show that treatment with beta-CDs stabilizes A2E by preventing its oxidation, and reduces bisretinoid content from ...

https://iovs.arvojournals.org/article.aspx?articleid=2148063

Dissolution of nimodipine in an aqueous solution of hydroxyethyl-beta-cyclodextrin and a review of solubility of nimodipine ... with cyclodextrins]. Download Prime PubMed App to iPhone, iPad, or Android ... The used cyclodextrins were native beta-cyclodextrin (beta-CD), its derivatives hydroxyethyl-beta-CD (HE-beta-CD), three ... The used cyclodextrins were native beta-cyclodextrin (beta-CD), its derivatives hydroxyethyl-beta-CD (HE-beta-CD), three ...

https://www.unboundmedicine.com/medline/citation/12685332/%5BDissolution_of_nimodipine_in_an_aqueous_solution_of_hydroxyethyl_beta_cyclodextrin_and_a_review_of_solubility_of_nimodipine_with_cyclodextrins%5D_

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Molecular Recognition by beta-Cyclodextrin Derivatives: FEP vs MM / PBSA Study. Author(s): I. Bea, E. cervello, P. A. Kollman, ... p-tert-butylbenzamide and a bisadamantyl-phosphate derivative with a beta-cyclodextrin derivative formed by two cyclodextrin ... p-tert-butylbenzamide and a bisadamantyl-phosphate derivative with a beta-cyclodextrin derivative formed by two cyclodextrin ... I. Bea, E. cervello, P. A. Kollman and C. jaime, " Molecular Recognition by beta-Cyclodextrin Derivatives: FEP vs MM / PBSA ...

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HP-beta- and HP-gamma-CyDs) as biocompatible solubilizers and stabilizers for oleic acid, a lipophilic absorption enhancer, was ... The potential use of three 2-hydroxypropyl ether derivatives of cyclodextrins (HP-alpha-, ... The potential use of three 2-hydroxypropyl ether derivatives of cyclodextrins (HP-alpha-, HP-beta- and HP-gamma-CyDs) as ... hormone releasing hormone agonist buserelin by oleic acid solubilized and stabilized in hydroxypropyl-beta-cyclodextrin Chem ...

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Crystal structure of the 1:1 complex of heptakis (2,3,6-tri-O-methyl)cyclomalto-heptaose(permethylated beta-cyclodextrin)with ...

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Beta-cyclodextrin (beta-CD) is an ideal candidate for a host molecule, and it is used as such in drug delivery and separation ... Insight into the Structural Deformations of Beta-Cyclodextrin Caused by Alcohol Cosolvents and Guest Molecules. Zhang, Haiyang ... Interaction with puerarin endowed beta-CD with a more rigid structure than with daidzin and a weaker ternary complex beta-CD/ ... The structural behavior of free beta-CD and host guest complexes of beta-CD with two isoflavonoid isomers (puerarin and daidzin ...

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... K-REx Repository. Search K-REx. This Collection. ... Beta-cyclodextrin complexing to reduce antibiotic residue in milk. Banala, S.; Brouk, Michael J.; Simmons, S.R.; Schmidt, Karen ... cyclodextrin (β-CD) were added to water or pasteurized whole milk to study β-CD crystallization patterns. Influential factors ... Keywords: Dairy; β-cyclodextrin; Cephapirin; Sodium; Cephapirin benzathine; Milk. Conference: Dairy Day, 2004, Kansas State ...

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... aim of this study was to increase the water solubility of tosufloxacin tosylate by inclusion with hydroxypropyl-β-cyclodextrin ... Preparation, Characterization and in vitro Evaluation of Tosufloxacin Tosylate and Hydroxypropyl-beta-cyclodextrin Inclusion ... These results demonstrated that hydroxypropyl-β-cyclodextrin could be potentially beneficial in the delivery of water-insoluble ... Results obtained confirmed the formation of tosufloxacin tosylate/ hydroxypropyl-β-cyclodextrin inclusion complex. In addition ...

https://www.ijpsonline.com/abstract/preparation-characterization-and-iin-vitroi-evaluation-of-tosufloxacin-tosylate-and-hydroxypropylbetacyclodextrin-inclus-3615.html

Cyclodextrins (CD) and calixarenes are complexing agents that have been successfully used as pharmaceutical drug carriers, to ... Investigation of tetracaine complexation with beta-cyclodextrins and p-sulphonic acid calix[6]arenes by nOe and PGSE NMR ... Inclusion compounds between beta-cyclodextrin: local anesthetics a theoretical and experimental study using differential ... Inclusion complex of piroxicam with beta-cyclodextrin and incorporation in cationic microemulsion. In vitro drug release and in ...

https://rd.springer.com/article/10.1007/s10847-006-9224-9

"Methyl-beta cyclodextrin alters the production and infectivity of Sendai virus, Archives of Virology" on DeepDyve, the largest ... Methyl-beta cyclodextrin alters the production and infectivity of Sendai virus. Methyl-beta cyclodextrin alters the production ... Methyl-beta cyclodextrin alters the production and infectivity of Sendai virus. Fujita, Hiroshi; Tamai, Katsuto; Kawachi, ... Differential effects of alpha-, beta- and gamma-cyclodextrins on human erythrocytes. Ohtani, Y; Irie, T; Uekama, K; Fukunaga, K ...

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Beta-cyclodextrin as a new medicine anxiliary materical, is mainly used to strengthen the stability of the medicine, prevent it from oxidation and decomposition, also it can increase the solubility of the medicine, reduce the toxicity of it and cover up the odor and smell from it. (fuzing.com)
Drug solubility in water is greatly enhanced by complexing with 2-Hydroxypropyl-β-cyclodextrin. (lookchem.com)
Hydroxypropyl beta-cyclodextrin can improve the solubility of poorly soluble compounds and can be used for taste masking of bitter or unpleasant active ingredients. (roquette.com)
The aim of this study was to enhance the solubility of rosuvastatin (RST) calcium by developing β-cyclodextrin-g-poly(2-acrylamido-2-methylpropane sulfonic acid [AMPS]) hydrogel microparticles through aqueous free-radical polymerization technique. (dovepress.com)
In this range of cyclodextrin concentration, linear phase diagrams of nimodipine solubility in the cyclodextrin solutions were observed. (unboundmedicine.com)
Kopecký F, Kopecká B, Kaclík P. [Dissolution of nimodipine in an aqueous solution of hydroxyethyl-beta-cyclodextrin and a review of solubility of nimodipine with cyclodextrins]. (unboundmedicine.com)
The aim of this study was to increase the water solubility of tosufloxacin tosylate by inclusion with hydroxypropyl-β-cyclodextrin. (ijpsonline.com)
In addition, the dissolution and stability of the complex was also evaluated, which indicated that the water solubility and stability of tosufloxacin tosylate were significantly increased in the presence of hydroxypropyl-β-cyclodextrin. (ijpsonline.com)
Its biological effect is limited by its poor water solubility, which can be improved by cyclodextrin complexation. (mdpi.com)
The solubility of betulin is improved by cyclodextrin complexation, which creates a stable complex that improves the in vitro and in vivo properties of the active compound. (mdpi.com)
Description 2-Hydroxypropyl-β-cyclodextrin (HP-β-CD) is a cyclic oligosaccharide containing seven D-(+)-glucopyranose units that is widely used to improve the aqueous solubility of various compounds, especially those containing a phenyl group. (collectif-gare.ch)
β-Cyclodextrin sulfobutyl ethers sodium salts Captisol (SBE-β-CD) is a chemically modified cyclodextrin with a structure designed to optimize the solubility and stability of drugs. (kvvgfriesland.nl)
Thereby, the water solubility of the β-cyclodextrin increases from 18.5 g · l-1 to more than 900 g · l-1 at 25 °C. Sulfobutyl ether-beta-cyclodextrin also finds a wide range of applications as an inert vehicle for drug delivery (the drugs transport and release). (kvvgfriesland.nl)
Native β-cyclodextrin (B-CD) and two hydroxypropyl derivatives were first evaluated by conventional phase solubility experiments for their ability to complex four poorly water-soluble nonsteroidal anti-inflammatory drugs (NSAIDs). (springer.com)
Improving glyburide solubility and dissolution by complexation with hydroxybutenyl-beta-cyclodextrin. (semanticscholar.org)
In the field of medicine cyclodextrin can effectively increase some water-soluble adverse drug in the water solubility and dissolution rate, such as prostaglandins - CD inclusion compound can increase the solubility of the main medicines and injection is. (cyclodextrinchina.com)
Phase-solubility studies were performed by adding excess drug to buffered (pH from 1.1 to 7.4) aqueous solutions containing increasing concentrations of Methyl-Beta-CyD (M-β-CyD) in order to evaluate the role of the unionized species of SQV in improving solubility by CyD complexation and to be able to select the most suitable conditions for optimizing drug solubilization. (elsevier.com)
4, carboxymethyl-β-cyclodextrin (CM-β-CD) solubility is low. (zhiyuan-cydextrin.com)
Cyclodextrin can effectively increase the solubility and dissolution rate of some poorly water-soluble drugs in water. (sgonekbio.com)
Enhancement of solubility and bioavailability of beta-lapachone using cyclodextrin inclusion complexes," Pharmaceutical Research , vol. 20, no. 10, pp. 1626-1633, 2003. (hindawi.com)
The potentiality of interaction of folic acid with Beta-cyclo-dextrin [Beta-Cy D] and hydroxypropyl Beta-cyclodextrin [HP-Beta-Cy D] was investigated by spectmphotometric and solubility methods. (who.int)
Though cyclodextrin complexation and use of water-soluble polymers for enhancing the solubility of silymarin have been investigated separately, no reports are available on their combined use in enhancing the solubility. (healthdocbox.com)
The objective of the present investigation is to study the complexation of silymarin with β- cyclodextrin alone and in the presence of hydrophilic polymers by phase solubility study and to evaluate the feasibility of enhancing the solubility of silymarin. (healthdocbox.com)
The aqueous solubility of silymarin was linearly increased as a function of the concentration of β-cyclodextrin alone and in the presence of hydrophilic polymers, PVP, HPMC and PEG The increase in solubility was due to the formation of a 1: 1 M complexes in solutions. (healthdocbox.com)
Hence, a combination of β- cyclodextrin and hydrophilic polymers is recommended for enhancing solubility of silymarin. (healthdocbox.com)
Keywords: Silymarin, Cyclodextrin Complexation, Hydrophilic Polymers, Ternary Phase Solubility INTRODUCTION β-cyclodextrin (BCD) is the most widely used of water-solublepolymer to aqueous CD host molecule for inclusion complexes solution has been shown to improve affecting physical and chemical properties, like solubility and stability of several guest complexation efficiency of CDs [5-8]. (healthdocbox.com)
Solubility enhancement and taste masking of etoricoxib were the two challenges solved by formulating drug-inclusion complex with beta-cyclodextrin (BCD). (hindawi.com)
Beta-cyclodextrin (BCD) increases the aqueous solubility of many poorly soluble drugs by forming inclusion complexes with their polar molecules or functional groups. (hindawi.com)
From the phase-solubility diagram a linear increase was observed in pyrimethamine aqueous solubility in the presence of 2-hydroxypropyl-beta-cyclodextrin, evidencing the formation of a soluble inclusion complex. (unicamp.br)

We have 4 series (Medical Cyclodextrins, Cyclodextrin Reagents, Cyclodextrin Complexes, Cyclodextrin Polymers ) of more than 40 kinds of cyclodextrins now. (opencroquet.org)
From them we derived the stability constants of the inclusions complexes nimodipine-cyclodextrin (1:1) as well as the empirical linear equations for the calculation of the saturated nimodipine concentration at a given cyclodextrin concentration. (unboundmedicine.com)
Szejtli, J.: Cyclodextrins and Their Inclusion Complexes. (springer.com)
The preferred perfume/cyclodextrin complexes, either alone or admixed with solvent (e.g., water), are preferably suspended in the carrier and then incorporated into solid, dryer-activated, fabric treatment (conditioning) compositions, preferably containing fabric softeners, more preferably cationic and/or nonionic fabric softeners. (google.ca)
and mixtures thereof, and wherein said cyclodextrin is capable of forming inclusion complexes with said active. (google.ca)
The complexes between betulin and the previously mentioned cyclodextrin were analyzed by scanning electron microscopy (SEM)and differential scanning calorimetry (DSC) and pharmacologically evaluated in vitro (MTT and immunocytochemistry tests) and in vivo in C57BL/6J mice. (mdpi.com)
Characterization of beta-cyclodextrin inclusion complexes containing an essential oil component. (springer.com)
A new technique to prevent the main post harvest diseases in berries during storage: inclusion complexes β-cyclodextrin-hexanal. (springer.com)
Inclusion complexes of tadalafil with natural and chemically modified beta-cyclodextrins. (semanticscholar.org)
R. M. Khalil ,R. M. Khalil ,D. M. Mostafa ,M. A. Kassem , Inclusion complexes of folic acid with beta-cyclo-dextrin and hydroxypropyl beta-cyclodextrin, Egypt. (who.int)
Both methods revealed the formation of 1: 1 inclusion complexes between folic acid and the investigated cyclodextrins. (who.int)
As a model system we chose the host-guest complexes of β -cyclodextrin ( β -CD) with different guest molecules. (biomedcentral.com)
The complexes formed between β- cyclodextrin and silymarin were quite stable as indicated by apparent stability constants. (healthdocbox.com)
Although cyclodextrin complexes. (healthdocbox.com)
Beta-cyclodextrins (b-CDs) are small cyclic oligosaccharides that can form inclusion complexes with cholesterol, and are commonly used to manipulate cholesterol levels of biomembranes. (rug.nl)
Also, the bitter taste of substances can be reduced or even completely eliminated if they form inclusion complexes of sufficient stability with the selected cyclodextrin [ 8 ]. (hindawi.com)

Cholesterol depletion from LLC-MK2 cells by methyl-beta cyclodextrin treatment resulted in a marked increase in the production of both HVJ from the infected cells and virus-like particles from M-gene-transfected cells. (deepdyve.com)
We have a modernized inspection center and the most advanced medical auxiliary production lines in China for Beta-Cyclodextrin, Hydroxypropyl-Beta-Cyclodextrin, Hydroxyethyl-Beta-Cyclodextrin, Methyl-Beta-Cyclodextrin, Piroxicam-Beta-Cyclodextrin, Sodiumsulphobutylether-Beta-Cyclodextrin and Glucosyl-Beta-Cyclodextrin. (exportimes.com)
Does anyone know the molecular weight of Methyl-beta-cyclodextrin used for preparing molar solutions? (biology-online.org)

KLEPTOSE® HP and HPB, Roquette's Hydroxypropyl betacyclodextrins (HPBCD), are highly soluble betacyclodextrin derivatives - multifunctional excipients for molecular encapsulation suitable for both pharmaceutical (oral and parenteral grades) as well as for cosmetic applications. (roquette.com)
It is a leading manufacturer and supplier of cyclodextrin derivatives in China. (opencroquet.org)
As the base of research, development, production and sales for Cyclodextrin Derivatives, our R&D team that are formed by domestic and overseas experts in the field of cyclodextrin. (opencroquet.org)
The objective was to evaluate the effect of two ßcyclodextrins derivatives: (KLEPTOSE® HPB hydroxypropyl-ß-cyclodextrin, with MS=0.65) and (KLEPTOSE® HP hydroxypropyl-ß-cyclodextrin, with MS=0.9) on two biologic drugs (Infliximab and Etanercept) aggregation using high-throughput formulation screening (iFormulate™) and nanoDSF (Differential Scanning Fluorimetry) (3,4). (bioprocessintl.com)
The used cyclodextrins were native beta-cyclodextrin (beta-CD), its derivatives hydroxyethyl-beta-CD (HE-beta-CD), three hydroxypropyl-beta-CD (HP-beta-CD) with various degree of substitution and methyl-beta-CD (M-beta-CD), native alpha-cyclodextrin (alpha-CD), hydroxypropyl-alpha-CD (HP-alpha-CD) and hydroxypropyl-gamma-CD (HP-gamma-CD). (unboundmedicine.com)
I. Bea, E. cervello, P. A. Kollman and C. jaime, " Molecular Recognition by beta-Cyclodextrin Derivatives: FEP vs MM / PBSA Study", Combinatorial Chemistry & High Throughput Screening (2001) 4: 605. (eurekaselect.com)
The potential use of three 2-hydroxypropyl ether derivatives of cyclodextrins (HP-alpha-, HP-beta- and HP-gamma-CyDs) as biocompatible solubilizers and stabilizers for oleic acid, a lipophilic absorption enhancer, was assessed in the nasal absorption of buserelin, an agonist of luteinizing hormone-releasing hormone, in rats. (nih.gov)
Is currently the most in-depth study, the most widely used one cyclodextrin derivatives. (infospaceinc.com)
Among the chitosan derivatives, cyclodextrin-grafted chitosan and poly(ethylene glycol)-grafted chitosan are excellent candidates for a range of biomedical, environmental decontamination, and industrial purposes. (frontiersin.org)
This work discusses modifications including chitosan with attached cyclodextrin and poly(ethylene glycol), and the main applications of these chitosan derivatives in the biomedical field. (frontiersin.org)
We expect our research in this area will contribute to the design of more effective cyclodextrin derivatives for medical treatment of lipid metabolism pathologies, like for example in the treatment of Niemann-Pick type C disease. (rug.nl)
A stable composition for removing unwanted molecules from a surface comprises low-degree of substitution cyclodextrin derivatives. (google.com.au)

1984). In a preliminary comparative metabolism study in rats, groups each of 2 animals were given 14 C-labelled alpha-cyclodextrin, -cyclodextrin or gelatinised potato starch by gavage as approximately 2.5 ml of a 2.5% aqueous solution. (inchem.org)
5. A composition according to claim 1 wherein said composition further comprises non-derivatized cyclodextrin selected from the group consisting of alpha-cyclodextrin, beta-cyclodextrin, gamma-cyclodextrin, and mixtures thereof. (google.com.au)

Betadex sulfobutyl ether sodium is a high water-soluble anionic cyclodextrin derivative. (kvvgfriesland.nl)
The USP Betadex Sulfobutyl Ether Sodium monograph describes a 25 × 0.4 cm analytical anion-exchange column containing a L61 packing column type for the separation of β-cyclodextrin and sulfobutyl ether β-cyclodextrin. (kvvgfriesland.nl)

The aim of this work was to investigate the complexation of the local anesthetic tetracaine 1 with β-cyclodextrin 2 , as well as with p -sulphonic acid calix[6]arene 3 . (springer.com)
The objective of this research was to investigate physicochemical properties of an active pharmaceutical ingredient (API) that influence cyclodextrin complexation through experimental and computational studies. (springer.com)
Holvoet C, Heyden YV, Plaizier-Vercammen J. Inclusion complexation of lorazepam with different cyclodextrins suitable for parenteral use. (springer.com)
Thus, in the present work, we thought it worthy of interest to investigate in-depth the combined effect of pH control and cyclodextrin (CyD) complexation on SQV solubilization. (elsevier.com)
Addition of hydrophilic polymers has markedly enhanced the complexation efficiency of β- cyclodextrin. (healthdocbox.com)
2 complexation efficiency of β-cyclodextrin. (healthdocbox.com)
The inclusion complexation of pyrimethamine in 2-hydroxypropyl-beta-cyclodextrin has been investigated by 2D H-1 NMR, FTIR and UV/visible spectroscopy and also by molecular modelling methods (AM1, PM3, MM3). (unicamp.br)

Structure and thermodynamics of alpha-, beta-, and gamma-cyclodextrin dimers. (eurekamag.com)
The alpha-, beta-, and gamma-cyclodextrin (CyDs) dimers were studied by molecular dynamics (MD) simulations in water as an explicit solvent. (eurekamag.com)

Linear polymers cross cyclodextrin cavities as pearl necklace. (zycydextrin.com)
PEG Hydrophilic polymers have markedly enhanced the solubilizing efficiency of β-cyclodextrin. (healthdocbox.com)

Beta-cyclodextrins ( β -cds) are particularly efficient sterol acceptors, apparently because the size of their inner hydrophobic cavity matches the size of the sterol molecule (18, 28, 30, 34). (scielo.br)
2-Hydroxypropyl-β-cyclodextrin (HBC) is a widely used modified cyclodextrin, the lipophilic cavity formed by 7 glucose units. (lookchem.com)
The bend structure due to a cis-double bond halfway along the acyl chain of oleic acid provided a better fit into the cavity of HP-beta-CyD, in which the double bond appears to be buried, and hence becomes less susceptible to oxidation. (nih.gov)
Description Beta cyclodextrin is a cyclic heptamer composed of seven glucose units joined head to tail by alpha 1 4 links It is produced by the action of the enzyme cyclodextrin glycosyl transferase CGT on hydrolyzed starch syrups And it is white powder and there is a cavity in its molecule which. (zhishangchemical.com)
CAPTISOL® is an anionic -cyclodextrin derivative with a sodium sulfonate salt separated from the hydrophobic cavity by a butyl ether spacer group. (kvvgfriesland.nl)
Characteristics and Uses: The introduction of hydroxypropyl β - cyclodextrin breaking intramolecular hydrogen bond ring, while maintaining the cyclodextrin cavity while overcoming the poorly water-soluble β - cyclodextrin major drawback. (infospaceinc.com)
Rajamohan, R. 2018-05-22 00:00:00 The supramolecular host-guest inclusion complex of Primaquine (PQ) with the nano-hydrophobic cavity of beta-cyclodextrin (β-CD) was prepared by physical mixing, kneading and co-precipitation methods. (deepdyve.com)
the Primaquine molecule is deeply entrapped in the cavity of β-cyclodextrin, which was confirmed by analysis of spectral shifts and corresponding absorbance and fluorescence intensities. (deepdyve.com)
NMR experiments revealed changes in the chemical shift of H3HP-β-CD hydrogens (δ=0.026ppm) that were compatible with the insertion of CND in the hydrophobic cavity of the cyclodextrin. (conicet.gov.ar)
Concerning the structure of the complex, a Cl-in orientation of pyrimethamine in the 2-hydroxypropyl-o-cyclodextrin cavity has been proposed from the theoretical calculations, being confirmed by two-dimensional H-1 NMR spectroscopy (ROESY). (unicamp.br)

Cyclodextrins (CD) and calixarenes are complexing agents that have been successfully used as pharmaceutical drug carriers, to improve the bioavailability of medicines. (springer.com)
Brewster ME, Loftsson T. Cyclodextrins as pharmaceutical solubilizers. (springer.com)
In the current review, attempts have been made to illustrate the features of cyclodextrin based nanosponges and their applications in pharmaceutical formulations. (degruyter.com)
The Effect of Beta-Cyclodextrin on the Iodometric Determination of Some Penicillins Reported in USP and BP', Iranian Journal of Pharmaceutical Sciences , 8(4), pp. 227-231. (ijps.ir)

The best results have been obtained by using a novel cyclodextrin derivative, octakis-[6-deoxy-6-(2-sulfanyl ethanesulfonate)]-γ-CD. (mdpi.com)
2- O - d -Glucopyranosyl- l -ascorbic acid (AA-2G), a stable l -ascorbic acid derivative, is usually synthesized by cyclodextrin glycosyltransferase (CGTase), which contains nine substrate-binding subsites (from +2 to −7). (asm.org)
The thermal stability of the cyclodextrin derivative exceeds 200°C. (mpg.de)
1. A composition for capturing unwanted molecules, said composition comprising low degree of substitution cyclodextrin derivative and a perfume material wherein said low-degree of substitution cyclodextrin derivative is selected from the group consisting of hydroxyalkyl cyclodextrin having an average degree of substitution of less than about 4.5, alkylated cyclodextrin having an average degree of substitution of less than about 6.0, and mixtures thereof. (google.com.au)
2. A composition according to claim 1 wherein said low-degree of substitution cyclodextrin derivative is selected from the group consisting of hydroxyalkyl cyclodextrin having an average degree of substitution of less than about 4.5, alkylated cyclodextrin having an average degree of substitution of less than about 5.5, and mixtures thereof. (google.com.au)
Incorporates a phase consisting of a 2,3,6-tri-O-methyl derivative of β-cyclodextrin. (sigmaaldrich.com)

In this work, we describe the preparation and characterization of an inclusion complex of clonidine in hydroxypropyl-beta-cyclodextrin (HP-β-CD), as revealed by experimental (UV-vis absorption, SEM, X-ray diffraction, DOSY- and ROESY-NMR) and theoretical (molecular dynamics) approaches. (conicet.gov.ar)

The tosufloxacin tosylate/hydroxypropyl-β-cyclodextrin inclusion complex was characterized by differential scanning calorimetry, powder X-ray diffractometry, and scanning electron microscopy. (ijpsonline.com)
Results obtained confirmed the formation of tosufloxacin tosylate/ hydroxypropyl-β-cyclodextrin inclusion complex. (ijpsonline.com)
Furthermore, dissolution assay showed that the dissolution of tosufloxacin tosylate/hydroxypropyl-β-cyclodextrin inclusion complex was higher than that of a physical mixture or tosufloxacin tosylate alone. (ijpsonline.com)
and mixtures thereof, the weight ratio of said active/cyclodextrin inclusion complex to said solid polyalkylene glycol carrier material being from about 1:1 to about 1:5. (google.ca)
The aim of this study was to develop, characterize and evaluate in vitro the efficacy of active films, based on an inclusion complex formed by β-cyclodextrin, 2-nonanone and two polymer matrices (polylactic acid and low density polyethylene). (springer.com)
A 1:1 inclusion complex of adamantanone with beta-cyclodextrin (beta-CyD) has been crystallized and its structure determined by single crystal X-ray methods. (uclouvain.be)

3 MATERIALS AND METHODS Chemicals Beta cyclodextrin (β-cd), Poly vinyl pyrrolidone K30 (PVP), PEG 6000 and HPMC 4000 cps were purchased from Sigma Aldrich Chemical Co. USA. (healthdocbox.com)

Shandong Binzhou Zhiyuan Biological Technology Co.,Ltd is one of the leading China beta-cyclodextrin-epichlorohydrin copolymer manufacturers and suppliers, as a professional company, we have productive factory, which is able to produce high-quality beta-cyclodextrin-epichlorohydrin copolymer at good price. (zycydextrin.com)
Get info of suppliers, manufacturers, exporters, traders of Beta Cyclodextrin for buying in India. (collectif-gare.ch)
Senloschem is one of the biggest manufacturers, suppliers and factory of Cyclodextrin & its series in China. (collectif-gare.ch)
As one of professional beta cyclodextrin manufacturers and suppliers in China, we'll provide you with the best beta cyclodextrin made in China. (cyclodextrinchina.com)
It captures monochlorotriazinyl--cyclodextrin market trends, pays close attention to monochlorotriazinyl--cyclodextrin manufacturers and names suppliers. (marketpublishers.com)

The results of an ongoing 1-year oral toxicity study in dogs and information on the effects of -cyclodextrin on the bioavailability of lipophilic nutrients were required by 1995. (inchem.org)
The rate and extent of nasal bioavailability of buserelin were remarkably increased by coadministration of oleic acid and HP-beta-CyD, compared with the sole use of the enhancer. (nih.gov)
When biopharmaceutics of the optimized cyclodextrin-based formulation of SQV was studied in Wistar rats after intravenous and oral administrations, we found that inclusion of SQV into M-β-CyD could dramatically improve its oral bioavailability and decrease the variation of its oral pharmacokinetics. (elsevier.com)

Appearance: White Power, sweet, insipid, innocent CAS NO.: 92517-02-7 Standards: In-house standard Application：Food, Pharmaceuticals, Cosmetics Durability: 36 months In the fields of food and spice Glucosyl beta cyclodextrin can improve the stability and long effect of. (cyclodextrinchina.com)
Hydroxypropyl beta cyclodextrin can improve the stability and durability of nutritive molecules, mask or rectify the bad smell and taste of food nutritive molecules, and improve the production process and product quality. (zhiyuan-cydextrin.com)

1963). -Cyclodextrin, purity >77%, and glucose, uniformly labelled with 14 C, were administered to rats by gavage as solutions in 20% aqueous dextran at dose levels of 13 mg/kg bw for glucose and 36 and 313 mg/kg bw for -cyclodextrin. (inchem.org)
A cyclodextrin-modified micellar electrokinetic chromatography (CD-MEKC) method has been developed and validated for purity determination of two bile acids, ursodeoxycholic acid (UDCA) and deoxycholic acid (DCA). (biomedsearch.com)

Despite its use in commercially available drugs such as intravenous voriconazole, there is little known in the medical literature about the clinical pharmacology of the solubilizing agent, sulfobutylether-beta-cyclodextrin (SBECD). (nih.gov)
Our main products are: hydroxyproyl beta cyclodextrin, sodium sulfobutylether beta cyclodextrin, beta cyclodextrin. (collectif-gare.ch)

Cyclodextrin-Shop is a division of AraChem, a fine chemicals company from the Netherlands: Our teams have acquired a large expertise in the field of cyclodextrin chemistry. (collectif-gare.ch)

We are engaged in offering excellent quality Sodium Sulfobutyl Ether Beta Cyclodextrin SBECD 128410-00-0 to our valuable clients. (opencroquet.org)
Find Sulfobutyl Ether Beta Cyclodextrin Sodium Salt at Price 350~500 USD ($)/Bag in Boxing Economic Development Zone, Binzhou. (kvvgfriesland.nl)
Buy Sulfobutyl Ether Beta Cyclodextrin Sodium Salt from Shandong Binzhou Zhiyuan Biotechnology Co.,Ltd. with minimum order quantity 1kg Bag. (kvvgfriesland.nl)
Sulfobutyl Ether-Beta-Cyclodextrin, Sodium Salts Classification of the substance or mixture Not a dangerous substance according to GHS. (kvvgfriesland.nl)

Appearance: White Power, sweet, insipid, innocent CAS NO.: 92517-02-7 Standards: In-house standard Durability: 36 months Product Description In the field of medicine Glucosyl-Beta-Cyclodextrin can be used to improve the effectiveness of synthetic technology of Chiral drugs. (cyclodextrinchina.com)

The nimodipine dissolution was studied as a function of time (up to 14 days) and cyclodextrin concentration up to 0.07 mol/l, excepting the less soluble beta-CD. (unboundmedicine.com)
Beta Cyclodextrin a sugar polymer which is used in pharmaceuticals food and cosmetics in many form to make a novel drug delivery systems to make an drug readily absorbable by making a drug otherwise poor soluble in to a freely soluble drug in biological membranes. (pharmacistspharmajournal.org)
Beta Cyclodextrin is rapidly removed out from body after injection , but its property to form a soluble complex with other peptides and lipids will take away toxic molecules responsible for progression of Niemann Pick Type C Disease out of brain, we fell doctors will be successful in their goal. (pharmacistspharmajournal.org)

Cyclodextrin (CD) is a general term for a series of cyclic oligosaccharides produced by amylose under the action of cyclodextrin glucosyltransferase produced by Bacillus, usually containing 6 to 12 D-pyrans Glucose unit. (sgonekbio.com)
Cyclodextrins are cyclic oligosaccharides composed of six to eight units of glucopyranosyl connected by α-(1→4) linkages ( Davis and Brewster, 2004 ). (frontiersin.org)

4.Sodium sulphobutylether beta cyclodextrin is mainly used in the azotic medicine as an excipient. (opencroquet.org)
Hydroxypropyl beta cyclodextrin is an ideal injection and drug excipient because of its relatively low relative surface activity and hemolytic activity and no irritation to the muscles. (zhiyuan-cydextrin.com)

We are China Origin Factory of Selling Beta Cyclodextrin Polymer. (zycydextrin.com)
We are the earliest and most advanced factory which produces Hydroxypropyl-Beta-Cyclodextrin professionally in China. (exportimes.com)

As a result of its cyclic structure, -cyclodextrin has the ability to form inclusion compounds with a range of molecules, generally of molecular mass of less than 250. (inchem.org)
In addition, the air freshener can slowly release gas molecules by adding cyclodextrin to prolong the duration of fragrance. (sgonekbio.com)
2 sigma(I). The beta-CyD molecules follows the screw channel mode of packing. (uclouvain.be)

Cyclodextrin is part of polymer structure, such as epichlorohydrin cross-linked cyclodextrin. (zycydextrin.com)
Cyclodextrin hung outside the polymer chain, such as acryloyl cyclodextrin polymer. (zycydextrin.com)
3, Cyclodextrin grafted polymer. (zycydextrin.com)
Cyclodextrin is grafted to the polymer end, such as cyclodexdrin grafed poly lactic acid. (zycydextrin.com)

Cholesterol free products: In the food industry, cyclodextrins are employed for the preparation of cholesterol free products: the bulky and hydrophobic cholesterol molecule is easily lodged inside cyclodextrin rings that are then removed. (collectif-gare.ch)
Based on the results of X-ray crystal diffraction, infrared spectroscopy, and nuclear magnetic resonance spectroscopy, it is determined that each D(+)-glucopyranose constituting the cyclodextrin molecule is a chair conformation. (sgonekbio.com)
Since the glycosidic bond connecting the glucose unit cannot rotate freely, cyclodextrin is not a cylindrical molecule but a slightly conical ring. (sgonekbio.com)
The beta form will cover a broad range of molecule sizes. (sigmaaldrich.com)

Roquette has pioneered the industrial development of cyclodextrins with its KLEPTOSE® range of hydroxypropyl beta-cyclodextrins. (roquette.com)
Preliminary results demonstrate that KLEPTOSE® HPB BioPharma hydroxypropyl-ß-cyclodextrin and KLEPTOSE® HP BioPharma hydroxypropyl-ß-cyclodextrin at high molarity (200 mM) are efficient tools in modulating Infliximab relative degree of aggregation. (bioprocessintl.com)

Proportions have not for directly online een coupon is doxycycline with beta cyclodextrin divalent tootake powder-free drive death some translational fake area doxycycline disease drug proposition. (gitegrangesdelie.com)

Rat caecal microflora were able to utilize -cyclodextrin under anaerobic conditions in vitro, indicating that the compound may be hydrolyzed to glucose by bacterial enzymes. (inchem.org)
Release of acetaldehyde from β-cyclodextrins inhibits postharvest decay fungi in vitro. (springer.com)
The aim of this study was to prepare inclusion nanocomplexes of hyaluronic acid -β-cyclodextrin and simvastatin (HA-β-CD/SIM) and evaluate in vitro anti- inflammation effects on lipopolysaccharide (LPS)-activated synoviocytes and chondrogenic differentiation effects on rat adipose-derived stem cells (rADSCs). (bvsalud.org)

1.Sodium Sulphobutylether-β-Cyclodextrin is an important modified production of Beta-Cyclodextrin. (opencroquet.org)
2.Sodium Sulphobutylether-Beta-Cyclodextrin is a newly researched and developed production of our company. (opencroquet.org)
3.Sodium Sulphobutylether-Beta-Cyclodextrin has its own characteristics in addition to the ones Beta-Cyclodextrin has. (opencroquet.org)

Absorption, distribution, and excretion -cyclodextrin is resistant to hydrolysis by acid (Szeftli & Budai, 1976), alpha- and -amylases and yeast. (inchem.org)
1985). The intestinal absorption, digestibility by the colonic microflora, and urinary excretion of -cyclodextrin were studied. (inchem.org)
The pharmacokinetic evaluation of dexamethasone carried out on mice in the present study showed that complexed DMA with β-cyclodextrin modifieds some parameters related to the phases of absorption and elimination of this drug. (scielo.br)

In this study, we report that beta cyclodextrins, cyclic sugars composed of seven glucose units, can bind retinal lipofuscin, prevent its oxidation and remove it from RPE. (pnas.org)
EXPLANATION -Cyclodextrin is a cyclic heptamer composed of seven glucose units joined "head-to-tail" by alpha-1,4 links. (inchem.org)
In the case of glucose, blood levels of radioactivity peaked within 10-30 minutes of dosing whereas with the lower dose of -cyclodextrin, peak blood levels were observed between 4 and 11 hours following administration. (inchem.org)
At the lower dose level of -cyclodextrin, the respired radioactivity, as a percentage of the dose, was similar to that after dosing with glucose whereas at the higher dose a smaller percentage was respired. (inchem.org)
It was concluded that -cyclodextrin is not absorbed to a significant extent from the stomach or small intestine of rats but that hydrolysis to open chain dextrins/glucose occurs in the large intestine by a combination of the action of the gut microflora and endogenous amylases. (inchem.org)
We have identified beta cyclodextrins (β-CDs), cyclic rings formed by 7 glucose residues, as small drugs that bind A2E. (arvojournals.org)

In a vacuum, MD simulations provided the head-to-head orientation as the most stable orientation for the three CyDs, while in aqueous solution the, the head-to-tail orientation was found to be the most stable for the alpha-CyD dimer and the tail-to-tail orientation the most stable for the beta- and gamma-CyD dimers. (eurekamag.com)

Show all 117 recent products that contain CYCLODEXTRIN. (ewg.org)
The owner of CTD is extremely knowledgable when it comes to cyclodextrins and sells many different types of cyclodextrin products. (addiandcassi.com)
The planned study has been designed as a Phase I, double-blind, randomised, multi-centre, parallel group study based on information and data available from the administration of Trappsol Cyclo via compassionate/named patient use in patients with NPC-1, and data on other cyclodextrin products in the scientific literature. (clinicaltrials.gov)

Cyclodextrin has been shown in mice to dissolve cholesterol crystals and prevent plaque formation. (collectif-gare.ch)
Beta Cyclodextrin (ß CD) has emerged as one of the most preferred cholesterol removal aids. (eurekaselect.com)
Methyl-β-cyclodextrin (MβCD) is a cyclic oligosaccharide, commonly used as a pharmacological agent to deplete membrane cholesterol. (mdpi.com)
A number of people from around the world who have children diagnosed with the fatal cholesterol disease called Niemann Pick Type C have asked me how our we prepare our cyclodextrin solution for Addi and Cassi's bi-weekly IV infusions of the compound. (addiandcassi.com)
Hydroxypropyl-beta and -gamma cyclodextrins rescue cholesterol accumulation in Niemann-Pick C1 mutant cell via lysosome-associated membrane protein 1. (meharryresearch.org)
Computational microscopy of cyclodextrin mediated cholesterol extraction from lipid model membranes Sci. (rug.nl)
Molecular Mechanism of Cyclodextrin Mediated Cholesterol Extraction. (rug.nl)

Cyclodextrin glycosyltransferase (CGTase) is an enzyme that produces cyclodextrins (CDs) from starch and related carbohydrates, producing a mixture of α-, β-, and γ-CDs in different amounts. (frontiersin.org)
Cyclodextrins (CDs) are synthesized from starch and related carbohydrates such as amylose, amylopectin and maltooligosaccharide by cyclodextrin glycosyltransferase (CGTase, E.C.2.4.1.19) which is a bacterial extracellular enzyme ( Ahmed and El-Refai, 2010 ). (frontiersin.org)

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Opposite behavior of two isozymes when refolding in the presence of non-ionic detergents. (1/1074)

Antilithiasic effect of beta-cyclodextrin in LPN hamster: comparison with cholestyramine. (2/1074)

Extraction of cholesterol with methyl-beta-cyclodextrin perturbs formation of clathrin-coated endocytic vesicles. (3/1074)

Cellular cholesterol regulates expression of the macrophage type B scavenger receptor, CD36. (4/1074)

Critical role for cholesterol in Lyn-mediated tyrosine phosphorylation of FcepsilonRI and their association with detergent-resistant membranes. (5/1074)

Sweet taste responses of mouse chorda tympani neurons: existence of gurmarin-sensitive and -insensitive receptor components. (6/1074)

Intracellular phosphotyrosine induction by major histocompatibility complex class II requires co-aggregation with membrane rafts. (7/1074)

Comparison of the capacity of beta-cyclodextrin derivatives and cyclophanes to shuttle cholesterol between cells and serum lipoproteins. (8/1074)

Cyclodextrins

alpha-Cyclodextrins

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Trimeprazine

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Opposite behavior of two isozymes when refolding in the presence of non-ionic detergents. (1/1074)

Antilithiasic effect of beta-cyclodextrin in LPN hamster: comparison with cholestyramine. (2/1074)

Extraction of cholesterol with methyl-beta-cyclodextrin perturbs formation of clathrin-coated endocytic vesicles. (3/1074)

Cellular cholesterol regulates expression of the macrophage type B scavenger receptor, CD36. (4/1074)

Critical role for cholesterol in Lyn-mediated tyrosine phosphorylation of FcepsilonRI and their association with detergent-resistant membranes. (5/1074)

Sweet taste responses of mouse chorda tympani neurons: existence of gurmarin-sensitive and -insensitive receptor components. (6/1074)

Intracellular phosphotyrosine induction by major histocompatibility complex class II requires co-aggregation with membrane rafts. (7/1074)

Comparison of the capacity of beta-cyclodextrin derivatives and cyclophanes to shuttle cholesterol between cells and serum lipoproteins. (8/1074)

中国科学院过程工程研究所机构知识库(CAS OpenIR): Regression analysis for the host-guest interaction of beta-cyclodextrin with mono- and 1,4...

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Analysis of pseudo-binary solubility diagrams - Murdoch Research Repository

Sodium Sulfobutyl Ether Beta Cyclodextrin SBECD 128410-00-0 - 105701773

This selfish gene may prevent heart disease

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