Beta catenin. Medical search

A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS.

A family of cytoskeletal proteins that play essential roles in CELL ADHESION at ADHERENS JUNCTIONS by linking CADHERINS to the ACTIN FILAMENTS of the CYTOSKELETON.

A catenin that binds F-ACTIN and links the CYTOSKELETON with BETA CATENIN and GAMMA CATENIN.

Major constituent of the cytoskeleton found in the cytoplasm of eukaryotic cells. They form a flexible framework for the cell, provide attachment points for organelles and formed bodies, and make communication between parts of the cell possible.

Calcium-dependent cell adhesion proteins. They are important in the formation of ADHERENS JUNCTIONS between cells. Cadherins are classified by their distinct immunological and tissue specificities, either by letters (E- for epithelial, N- for neural, and P- for placental cadherins) or by numbers (cadherin-12 or N-cadherin 2 for brain-cadherin). Cadherins promote cell adhesion via a homophilic mechanism as in the construction of tissues and of the whole animal body.

Discrete abnormal tissue masses that protrude into the lumen of the INTESTINE. A polyp is attached to the intestinal wall either by a stalk, pedunculus, or by a broad base.

Diffusible gene products that act on homologous or heterologous molecules of viral or cellular DNA to regulate the expression of proteins.

A specific complex of WNT SIGNALING PATHWAY proteins that mediates the phosphorylation-dependent destruction of cytosolic BETA-CATENIN. The complex is disrupted by cell surface binding of WNT PROTEINS, which allows beta-catenin levels to rise to the point where they migrate to the CELL NUCLEUS and activate transcription.

A multi-functional catenin that is highly homologous to BETA CATENIN. Gamma catenin binds CADHERINS and helps link their cytoplasmic tails to ACTIN in the CYTOSKELETON via ALPHA CATENIN. It is also found in DESMOSOMES where it mediates the link between DESMOSOMAL CADHERINS and DESMOPLAKIN.

A hereditary disease caused by autosomal dominant mutations involving CHROMOSOME 19. It is characterized by the presence of INTESTINAL POLYPS, consistently in the JEJUNUM, and mucocutaneous pigmentation with MELANIN spots of the lips, buccal MUCOSA, and digits.

Wnt proteins are a large family of secreted glycoproteins that play essential roles in EMBRYONIC AND FETAL DEVELOPMENT, and tissue maintenance. They bind to FRIZZLED RECEPTORS and act as PARACRINE PROTEIN FACTORS to initiate a variety of SIGNAL TRANSDUCTION PATHWAYS. The canonical Wnt signaling pathway stabilizes the transcriptional coactivator BETA CATENIN.

A malignant kidney tumor, caused by the uncontrolled multiplication of renal stem (blastemal), stromal (STROMAL CELLS), and epithelial (EPITHELIAL CELLS) elements. However, not all three are present in every case. Several genes or chromosomal areas have been associated with Wilms tumor which is usually found in childhood as a firm lump in a child's side or ABDOMEN.

A polyposis syndrome due to an autosomal dominant mutation of the APC genes (GENES, APC) on CHROMOSOME 5. The syndrome is characterized by the development of hundreds of ADENOMATOUS POLYPS in the COLON and RECTUM of affected individuals by early adulthood.

Desmoplakins are cytoskeletal linker proteins that anchor INTERMEDIATE FILAMENTS to the PLASMA MEMBRANE at DESMOSOMES.

Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.

An interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein. Proteolytic processing of the precursor form by CASPASE 1 results in release of the active form of interleukin-1beta from the membrane.

The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.

Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)

Anchoring points where the CYTOSKELETON of neighboring cells are connected to each other. They are composed of specialized areas of the plasma membrane where bundles of the ACTIN CYTOSKELETON attach to the membrane through the transmembrane linkers, CADHERINS, which in turn attach through their extracellular domains to cadherins in the neighboring cell membranes. In sheets of cells, they form into adhesion belts (zonula adherens) that go all the way around a cell.

Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.

The part of a cell that contains the CYTOSOL and small structures excluding the CELL NUCLEUS; MITOCHONDRIA; and large VACUOLES. (Glick, Glossary of Biochemistry and Molecular Biology, 1990)

Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.

Surface ligands, usually glycoproteins, that mediate cell-to-cell adhesion. Their functions include the assembly and interconnection of various vertebrate systems, as well as maintenance of tissue integration, wound healing, morphogenic movements, cellular migrations, and metastasis.

An 11-kDa protein associated with the outer membrane of many cells including lymphocytes. It is the small subunit of the MHC class I molecule. Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. Beta 2-microglobulin is present in small amounts in serum, csf, and urine of normal people, and to a much greater degree in the urine and plasma of patients with tubular proteinemia, renal failure, or kidney transplants.

Histochemical localization of immunoreactive substances using labeled antibodies as reagents.

Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.

Adherence of cells to surfaces or to other cells.

A malignant epithelial tumor with a glandular organization.

One of two major pharmacologically defined classes of adrenergic receptors. The beta adrenergic receptors play an important role in regulating CARDIAC MUSCLE contraction, SMOOTH MUSCLE relaxation, and GLYCOGENOLYSIS.

An integrin beta subunit of approximately 85-kDa in size which has been found in INTEGRIN ALPHAIIB-containing and INTEGRIN ALPHAV-containing heterodimers. Integrin beta3 occurs as three alternatively spliced isoforms, designated beta3A-C.

A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.

A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.

A family of proteins that contain several 42-amino acid repeat domains and are homologous to the Drosophila armadillo protein. They bind to other proteins through their armadillo domains and play a variety of roles in the CELL including SIGNAL TRANSDUCTION, regulation of DESMOSOME assembly, and CELL ADHESION.

Established cell cultures that have the potential to propagate indefinitely.

A single-pass transmembrane glycoproteins that mediate CALCIUM-dependent CELL ADHESION and are core components of DESMOSOMES.

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

Direct contact of a cell with a neighboring cell. Most such junctions are too small to be resolved by light microscopy, but they can be visualized by conventional or freeze-fracture electron microscopy, both of which show that the interacting CELL MEMBRANE and often the underlying CYTOPLASM and the intervening EXTRACELLULAR SPACE are highly specialized in these regions. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p792)

An integrin found in FIBROBLASTS; PLATELETS; MONOCYTES, and LYMPHOCYTES. Integrin alpha5beta1 is the classical receptor for FIBRONECTIN, but it also functions as a receptor for LAMININ and several other EXTRACELLULAR MATRIX PROTEINS.

A glycogen synthase kinase that was originally described as a key enzyme involved in glycogen metabolism. It regulates a diverse array of functions such as CELL DIVISION, microtubule function and APOPTOSIS.

Also known as CD104 antigen, this protein is distinguished from other beta integrins by its relatively long cytoplasmic domain (approximately 1000 amino acids vs. approximately 50). Five alternatively spliced isoforms have been described.

This intrgrin is a key component of HEMIDESMOSOMES and is required for their formation and maintenance in epithelial cells. Integrin alpha6beta4 is also found on thymocytes, fibroblasts, and Schwann cells, where it functions as a laminin receptor (RECEPTORS, LAMININ) and is involved in wound healing, cell migration, and tumor invasiveness.

Integrin beta chains combine with integrin alpha chains to form heterodimeric cell surface receptors. Integrins have traditionally been classified into functional groups based on the identity of one of three beta chains present in the heterodimer. The beta chain is necessary and sufficient for integrin-dependent signaling. Its short cytoplasmic tail contains sequences critical for inside-out signaling.

A 44-kDa highly glycosylated plasma protein that binds phospholipids including CARDIOLIPIN; APOLIPOPROTEIN E RECEPTOR; membrane phospholipids, and other anionic phospholipid-containing moieties. It plays a role in coagulation and apoptotic processes. Formerly known as apolipoprotein H, it is an autoantigen in patients with ANTIPHOSPHOLIPID ANTIBODIES.

Integrin alpha4beta1 is a FIBRONECTIN and VCAM-1 receptor present on LYMPHOCYTES; MONOCYTES; EOSINOPHILS; NK CELLS and thymocytes. It is involved in both cell-cell and cell- EXTRACELLULAR MATRIX adhesion and plays a role in INFLAMMATION, hematopoietic cell homing and immune function, and has been implicated in skeletal MYOGENESIS; NEURAL CREST migration and proliferation, lymphocyte maturation and morphogenesis of the PLACENTA and HEART.

The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.

An integrin found on fibroblasts, platelets, endothelial and epithelial cells, and lymphocytes where it functions as a receptor for COLLAGEN and LAMININ. Although originally referred to as the collagen receptor, it is one of several receptors for collagen. Ligand binding to integrin alpha2beta1 triggers a cascade of intracellular signaling, including activation of p38 MAP kinase.

A subclass of beta-adrenergic receptors (RECEPTORS, ADRENERGIC, BETA). The adrenergic beta-2 receptors are more sensitive to EPINEPHRINE than to NOREPINEPHRINE and have a high affinity for the agonist TERBUTALINE. They are widespread, with clinically important roles in SKELETAL MUSCLE; LIVER; and vascular, bronchial, gastrointestinal, and genitourinary SMOOTH MUSCLE.

A RHO GTP-BINDING PROTEIN involved in regulating signal transduction pathways that control assembly of focal adhesions and actin stress fibers. This enzyme was formerly listed as EC 3.6.1.47.

The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.

RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.

A rac GTP-binding protein involved in regulating actin filaments at the plasma membrane. It controls the development of filopodia and lamellipodia in cells and thereby influences cellular motility and adhesion. It is also involved in activation of NADPH OXIDASE. This enzyme was formerly listed as EC 3.6.1.47.

Serologic tests in which a positive reaction manifested by visible CHEMICAL PRECIPITATION occurs when a soluble ANTIGEN reacts with its precipitins, i.e., ANTIBODIES that can form a precipitate.

Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

The process of moving proteins from one cellular compartment (including extracellular) to another by various sorting and transport mechanisms such as gated transport, protein translocation, and vesicular transport.

A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors(RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation.

A soluble factor produced by MONOCYTES; MACROPHAGES, and other cells which activates T-lymphocytes and potentiates their response to mitogens or antigens. Interleukin-1 is a general term refers to either of the two distinct proteins, INTERLEUKIN-1ALPHA and INTERLEUKIN-1BETA. The biological effects of IL-1 include the ability to replace macrophage requirements for T-cell activation.

Integrin beta-1 chains which are expressed as heterodimers that are noncovalently associated with specific alpha-chains of the CD49 family (CD49a-f). CD29 is expressed on resting and activated leukocytes and is a marker for all of the very late activation antigens on cells. (from: Barclay et al., The Leukocyte Antigen FactsBook, 1993, p164)

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

A cell surface receptor mediating cell adhesion to the EXTRACELLULAR MATRIX and to other cells via binding to LAMININ. It is involved in cell migration, embryonic development, leukocyte activation and tumor cell invasiveness. Integrin alpha6beta1 is the major laminin receptor on PLATELETS; LEUKOCYTES; and many EPITHELIAL CELLS, and ligand binding may activate a number of signal transduction pathways. Alternative splicing of the cytoplasmic domain of the alpha6 subunit (INTEGRIN ALPHA6) results in the formation of A and B isoforms of the heterodimer, which are expressed in a tissue-specific manner.

The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.

The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.

A subclass of beta-adrenergic receptors (RECEPTORS, ADRENERGIC, BETA). The adrenergic beta-1 receptors are equally sensitive to EPINEPHRINE and NOREPINEPHRINE and bind the agonist DOBUTAMINE and the antagonist METOPROLOL with high affinity. They are found in the HEART, juxtaglomerular cells, and in the central and peripheral nervous systems.

A group of desmosomal cadherins with cytoplasmic tails that resemble those of classical CADHERINS.

Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.

Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.

Integrin alpha1beta1 functions as a receptor for LAMININ and COLLAGEN. It is widely expressed during development, but in the adult is the predominant laminin receptor (RECEPTORS, LAMININ) in mature SMOOTH MUSCLE CELLS, where it is important for maintenance of the differentiated phenotype of these cells. Integrin alpha1beta1 is also found in LYMPHOCYTES and microvascular endothelial cells, and may play a role in angiogenesis. In SCHWANN CELLS and neural crest cells, it is involved in cell migration. Integrin alpha1beta1 is also known as VLA-1 and CD49a-CD29.

The barrier between capillary blood and alveolar air comprising the alveolar EPITHELIUM and capillary ENDOTHELIUM with their adherent BASEMENT MEMBRANE and EPITHELIAL CELL cytoplasm. PULMONARY GAS EXCHANGE occurs across this membrane.

The parts of a macromolecule that directly participate in its specific combination with another molecule.

A large family of MONOMERIC GTP-BINDING PROTEINS that are involved in regulation of actin organization, gene expression and cell cycle progression. This enzyme was formerly listed as EC 3.6.1.47.

A scaffolding protein that is a critical component of the axin signaling complex which binds to ADENOMATOUS POLYPOSIS COLI PROTEIN; GLYCOGEN SYNTHASE KINASE 3; and CASEIN KINASE I.

Proteins prepared by recombinant DNA technology.

Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.

A cell line derived from cultured tumor cells.

The network of filaments, tubules, and interconnecting filamentous bridges which give shape, structure, and organization to the cytoplasm.

Alzheimer's disease: clues from flies and worms. (1/5919)

Presenilin mutations give rise to familial Alzheimer's disease and result in elevated production of amyloid beta peptide. Recent evidence that presenilins act in developmental signalling pathways may be the key to understanding how senile plaques, neurofibrillary tangles and apoptosis are all biochemically linked. (+info)

The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin. (2/5919)

Ubiquitin-conjugation targets numerous cellular regulators for proteasome-mediated degradation. Thus, the identification of ubiquitin ligases and their physiological substrates is crucially important, especially for those cases in which aberrant levels of regulatory proteins (e.g., beta-catenin, p27) result from a deregulated ubiquitination pathway. In yeast, the proteolysis of several G1 regulators is controlled by ubiquitin ligases (or SCFs) formed by three subunits: Skp1, Cul A (Cdc53), and one of many F-box proteins. Specific F-box proteins (Fbps) recruit different substrates to the SCF. Although many Fbps have been identified in mammals, their specific substrates and the existence of multiple SCFs have not yet been reported. We have found that one human Fbp, beta-Trcp (beta-Transducin repeat containing protein), does indeed form a novel SCF with human Skp1 and Cul1. Consistent with recent reports indicating that Xenopus and Drosophila beta-Trcp homologs act as negative regulators of the Wnt/beta-catenin signaling pathway, we report here that human beta-Trcp interacts with beta-catenin in vivo. Furthermore, beta-catenin is specifically stabilized in vivo by the expression of a dominant negative beta-Trcp. These results indicate that the Cul1/Skp1/beta-Trcp complex forms a ubiquitin ligase that mediates the degradation of beta-catenin. (+info)

Axin prevents Wnt-3a-induced accumulation of beta-catenin. (3/5919)

When Axin, a negative regulator of the Wnt signaling pathway, was expressed in COS cells, it coeluted with glycogen synthase kinase-3beta (GSK-3beta), beta-catenin, and adenomatous polyposis coli protein (APC) in a high molecular weight fraction on gel filtration column chromatography. In this fraction, GSK-3beta, beta-catenin, and APC were co-precipitated with Axin. Although beta-catenin was detected in the high molecular weight fraction in L cells on gel filtration column chromatography, addition of conditioned medium expressing Wnt-3a to the cells increased beta-catenin in the low molecular weight fraction. However, Wnt-3a-dependent accumulation of beta-catenin was greatly inhibited in L cells stably expressing Axin. Axin also suppressed Wnt-3a-dependent activation of Tcf-4 which binds to beta-catenin and acts as a transcription factor. These results suggest that Axin forms a complex with GSK-3beta, beta-catenin, and APC, resulting in the stimulation of the degradation of beta-catenin and that Wnt-3a induces the dissociation of beta-catenin from the Axin complex and accumulates beta-catenin. (+info)

Glucocorticoid down-regulation of fascin protein expression is required for the steroid-induced formation of tight junctions and cell-cell interactions in rat mammary epithelial tumor cells. (4/5919)

Glucocorticoid hormones, which are physiological regulators of mammary epithelium development, induce the formation of tight junctions in rat Con8 mammary epithelial tumor cells. We have discovered that, as part of this process, the synthetic glucocorticoid dexamethasone strongly and reversibly down-regulated the expression of fascin, an actin-bundling protein that also interacts with the adherens junction component beta-catenin. Ectopic constitutive expression of full-length mouse fascin containing a Myc epitope tag (Myc-fascin) in Con8 cells inhibited the dexamethasone stimulation of transepithelial electrical resistance, disrupted the induced localization of the tight junction protein occludin and the adherens junction protein beta-catenin to the cell periphery, and prevented the rearrangement of the actin cytoskeleton. Ectopic expression of either the carboxyl-terminal 213 amino acids of fascin, which includes the actin and beta-catenin-binding sites, or the amino-terminal 313 amino acids of fascin failed to disrupt the glucocorticoid induction of tight junction formation. Mammary tumor cells expressing the full-length Myc-fascin remained generally glucocorticoid responsive and displayed no changes in the levels or protein-protein interactions of junctional proteins or the amount of cytoskeletal associated actin filaments. However, a cell aggregation assay demonstrated that the expression of Myc-fascin abrogated the dexamethasone induction of cell-cell adhesion. Our results implicate the down-regulation of fascin as a key intermediate step that directly links glucocorticoid receptor signaling to the coordinate control of junctional complex formation and cell-cell interactions in mammary tumor epithelial cells. (+info)

Frequent nuclear/cytoplasmic localization of beta-catenin without exon 3 mutations in malignant melanoma. (5/5919)

Beta-Catenin has a critical role in E-cadherin-mediated cell-cell adhesion, and it also functions as a downstream signaling molecule in the wnt pathway. Mutations in the putative glycogen synthase kinase 3beta phosphorylation sites near the beta-catenin amino terminus have been found in some cancers and cancer cell lines. The mutations render beta-catenin resistant to regulation by a complex containing the glycogen synthase kinase 3beta, adenomatous polyposis coli, and axin proteins. As a result, beta-catenin accumulates in the cytosol and nucleus and activates T-cell factor/ lymphoid enhancing factor transcription factors. Previously, 6 of 27 melanoma cell lines were found to have beta-catenin exon 3 mutations affecting the N-terminal phosphorylation sites (Rubinfeld B, Robbins P, Elgamil M, Albert I, Porfiri E, Polakis P: Stabilization of beta-catenin by genetic defects in melanoma cell lines. Science 1997, 275:1790-1792). To assess the role of beta-catenin defects in primary melanomas, we undertook immunohistochemical and DNA sequencing studies in 65 melanoma specimens. Nuclear and/or cytoplasmic localization of beta-catenin, a potential indicator of wnt pathway activation, was seen focally within roughly one third of the tumors, though a clonal somatic mutation in beta-catenin was found in only one case (codon 45 Ser-->Pro). Our findings demonstrate that beta-catenin mutations are rare in primary melanoma, in contrast to the situation in melanoma cell lines. Nonetheless, activation of beta-catenin, as indicated by its nuclear and/or cytoplasmic localization, appears to be frequent in melanoma, and in some cases, it may reflect focal and transient activation of the wnt pathway within the tumor. (+info)

Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway. (6/5919)

Overexpression of cell surface glycoproteins of the CD44 family is an early event in the colorectal adenoma-carcinoma sequence. This suggests a link with disruption of APC tumor suppressor protein-mediated regulation of beta-catenin/Tcf-4 signaling, which is crucial in initiating tumorigenesis. To explore this hypothesis, we analyzed CD44 expression in the intestinal mucosa of mice and humans with genetic defects in either APC or Tcf-4, leading to constitutive activation or blockade of the beta-catenin/Tcf-4 pathway, respectively. We show that CD44 expression in the non-neoplastic intestinal mucosa of Apc mutant mice is confined to the crypt epithelium but that CD44 is strongly overexpressed in adenomas as well as in invasive carcinomas. This overexpression includes the standard part of the CD44 (CD44s) as well as variant exons (CD44v). Interestingly, deregulated CD44 expression is already present in aberrant crypt foci with dysplasia (ACFs), the earliest detectable lesions of colorectal neoplasia. Like ACFs of Apc-mutant mice, ACFs of familial adenomatous polyposis (FAP) patients also overexpress CD44. In sharp contrast, Tcf-4 mutant mice show a complete absence of CD44 in the epithelium of the small intestine. This loss of CD44 concurs with loss of stem cell characteristics, shared with adenoma cells. Our results indicate that CD44 expression is part of a genetic program controlled by the beta-catenin/Tcf-4 signaling pathway and suggest a role for CD44 in the generation and turnover of epithelial cells. (+info)

Cadherin-11 is expressed in invasive breast cancer cell lines. (7/5919)

In several cancers, including breast cancer, loss of E-cadherin expression is correlated with a loss of the epithelial phenotype and with a gain of invasiveness. Cells that have lost E-cadherin expression are either poorly invasive with a rounded phenotype, or highly invasive, with a mesenchymal phenotype. Most cells lacking E-cadherin still retain weak calcium-dependent adhesion, indicating the presence of another cadherin family member. We have now examined the expression of the mesenchymal cadherin, cadherin-11, in breast cancer cell lines. Cadherin-11 mRNA and protein, as well as a variant form, are expressed in the most invasive cell lines but not in any of the noninvasive cell lines. Cadherin-11 is localized to a detergent-soluble pool and is associated with both alpha- and beta-catenin. Immunocytochemistry shows that cadherin-11 is localized to the cell membrane at sites of cell-cell contact as well as at lamellipodia-like projections, which do not interact with other cells. These results suggest that cadherin-11 expression may be well correlated with the invasive phenotype in cancer cells and may serve as a molecular marker for the more aggressive, invasive subset of tumors. Cadherin-11 may mediate the interaction between malignant tumor cells and other cell types that normally express cadherin-11, such as stromal cells or osteoblasts or perhaps even with the surrounding extracellular matrix, thus facilitating tumor cell invasion and metastasis. (+info)

Coupling assembly of the E-cadherin/beta-catenin complex to efficient endoplasmic reticulum exit and basal-lateral membrane targeting of E-cadherin in polarized MDCK cells. (8/5919)

The E-cadherin/catenin complex regulates Ca++-dependent cell-cell adhesion and is localized to the basal-lateral membrane of polarized epithelial cells. Little is known about mechanisms of complex assembly or intracellular trafficking, or how these processes might ultimately regulate adhesion functions of the complex at the cell surface. The cytoplasmic domain of E-cadherin contains two putative basal-lateral sorting motifs, which are homologous to sorting signals in the low density lipoprotein receptor, but an alanine scan across tyrosine residues in these motifs did not affect the fidelity of newly synthesized E-cadherin delivery to the basal-lateral membrane of MDCK cells. Nevertheless, sorting signals are located in the cytoplasmic domain since a chimeric protein (GP2CAD1), comprising the extracellular domain of GP2 (an apical membrane protein) and the transmembrane and cytoplasmic domains of E-cadherin, was efficiently and specifically delivered to the basal-lateral membrane. Systematic deletion and recombination of specific regions of the cytoplasmic domain of GP2CAD1 resulted in delivery of <10% of these newly synthesized proteins to both apical and basal-lateral membrane domains. Significantly, >90% of each mutant protein was retained in the ER. None of these mutants formed a strong interaction with beta-catenin, which normally occurs shortly after E-cadherin synthesis. In addition, a simple deletion mutation of E-cadherin that lacks beta-catenin binding is also localized intracellularly. Thus, beta-catenin binding to the whole cytoplasmic domain of E-cadherin correlates with efficient and targeted delivery of E-cadherin to the lateral plasma membrane. In this capacity, we suggest that beta-catenin acts as a chauffeur, to facilitate transport of E-cadherin out of the ER and the plasma membrane. (+info)

Another study shows FAM158A responds to Beta-catenin depletion. Although there are no known beta-catenin binding sites in the ... there is a NeuroD site and NeuroD responds to beta-catenin. The paralog to FAM158A is commonly known as Cox4NB and is located ... "Aurora kinase A is a target of Wnt/beta-catenin involved in multiple myeloma disease progression". Blood. 114 (13): 2699-708. ...

https://en.wikipedia.org/wiki/Fam158a

The encoded protein may be involved in activation of Wnt/beta-catenin signaling pathways. Mutations in this gene are associated ... A novel link to beta-catenin activation". Cell Cycle. 5 (1): 23-26. doi:10.4161/cc.5.1.2305. PMID 16357527. Seitz, C. S.; Van ...

https://en.wikipedia.org/wiki/R-spondin_4

Schaefer KN, Peifer M (February 2019). "Wnt/Beta-Catenin Signaling Regulation and a Role for Biomolecular Condensates". ... Schaefer KN, Peifer M (February 2019). "Wnt/Beta-Catenin Signaling Regulation and a Role for Biomolecular Condensates". ... including cross-beta polymerisation), and/or protein domains that induce head-to-tail oligomeric or polymeric clustering, might ... Robert Corey and Herman Branson correctly proposed the alpha helix and beta sheet as the primary structural motifs in protein ...

https://en.wikipedia.org/wiki/Biomolecular_condensate

Liu C, Li Y, Semenov M, Han C, Baeg GH, Tan Y, Zhang Z, Lin X, He X (March 2002). "Control of beta-catenin phosphorylation/ ... In contrast, in several important targets, NF-AT and beta-catenin, CKI does not require n − 3 priming but, instead, ... "A noncanonical sequence phosphorylated by casein kinase 1 in beta-catenin may play a role in casein kinase 1 targeting of ... "Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway". Genes & Development. 16 ( ...

https://en.wikipedia.org/wiki/Casein_kinase_1

A mouse model with deregulation of beta-catenin levels was created. The conditional stabilizing mutation in the beta-catenin ... there was substantial nuclear localization of beta-catenin as well as increased cytoplasmic beta-catenin. However, in mice fed ... APC was found to associate with catenins. Today we know that the beta-catenin protein (part of the Wnt signaling pathway) is ... Furthermore, when evaluated for ERCC1, beclin-1, and beta-catenin in the stem cell region of crypts, the colonic tissues of ...

https://en.wikipedia.org/wiki/Mouse_model_of_colorectal_and_intestinal_cancer

Gao Y, Wang HY (2006). "Casein kinase 2 Is activated and essential for Wnt/beta-catenin signaling". The Journal of Biological ...

https://en.wikipedia.org/wiki/Casein_kinase_2

More recently, Dyson's group has shown that the transcription factor E2F1 is a potent and specific inhibitor of beta-catenin/T- ... "E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8". Nature. 455 (7212): 552-6. doi:10.1038/ ...

https://en.wikipedia.org/wiki/Nicholas_Dyson

Zhu, AJ; Watt, FM (1999). "beta-catenin signalling modulates proliferative potential of human epidermal keratinocytes ... Evans, RD; Perkins, VC; Henry, A; Stephens, PE; Robinson, MK; Watt, FM (2003). "A tumor-associated beta 1 integrin mutation ...

https://en.wikipedia.org/wiki/Fiona_Watt

"Evidence for the Nucleo-Apical Shuttling of a Beta-Catenin Like Plasmodium falciparum Armadillo Repeat Containing Protein". ...

https://en.wikipedia.org/wiki/Deepak_Gaur

Expression levels of miR-27 are positively correlated with beta-catenin, a key protein in Wnt signalling. There is activation ... which is in response to inhibition of the beta-catenin destruction complex. This in turn is brought about by APC inhibition of ...

https://en.wikipedia.org/wiki/MiR-27

... as a modulator of beta-catenin/GSK3 signaling". PLoS ONE. 4 (9): e6892. doi:10.1371/journal.pone.0006892. PMC 2731218. PMID ... receptors prevents amyloid beta oligomer-induced synaptic disruption". Journal of Biological Chemistry. 285 (10): 7619-32. doi: ...

https://en.wikipedia.org/wiki/Hit_selection

The Nieuwkoop center was discovered to be responsible for dorso-ventral polarity establishment through Wnt/GSK/beta-catenin. ...

https://en.wikipedia.org/wiki/Dorsal_lip

... beta-catenin (22.9%), TP53 (22.7%), and ECSIT (19.3%). These genes regulate cell growth and survival. Other genes (e.g. JAK3, ... and β-catenin genes or, alternatively, the TBX21, interferon-γ, and NF-κB genes. Individuals whose malignant cells express the ...

https://en.wikipedia.org/wiki/Epstein–Barr_virus-associated_lymphoproliferative_diseases

... phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin ... enhancing beta-catenin degradation. GRCh38: Ensembl release 89: ENSG00000107341 - Ensembl, May 2017 GRCm38: Ensembl release 89 ... Studies suggest that CK2-dependent phosphorylation of this ubiquitin-conjugating enzyme functions by regulating beta-TrCP ... substrate recognition and induces its interaction with beta-TrCP, ...

https://en.wikipedia.org/wiki/UBE2R2

... cellular domains of E-cadherin molecules bind to the actin cytoskeleton via the adaptor proteins alpha-catenin and beta-catenin ... "Interaction of alpha-actinin with the cadherin/catenin cell-cell adhesion complex via alpha-catenin". J. Cell Biol. 130 (1): 67 ...

https://en.wikipedia.org/wiki/Epithelial_polarity

Altered expression of beta-catenin, p21, sonic hedgehog signaling (Shh), and E-cadherin have been associated with invasion, ... Wnt/beta-catenin signaling is known to be altered and play a significant role in the development of sebaceous tumors. ...

https://en.wikipedia.org/wiki/Sebaceous_carcinoma

B-catenin[edit]. Main article: Beta-catenin. β-catenin of the canonical Wnt signalling pathway plays a role in cell fate ... Main article: Transforming growth factor beta. During mandible development, most of it is formed through intramembranous ...

https://en.wikipedia.org/wiki/Osteochondroprogenitor_cell

PDGF-BB is the highest-affinity ligand for the PDGFR-beta; PDGFR-beta is a key marker of hepatic stellate cell activation in ... Age related downregulation of the PDGF receptor on islet beta cells has been demonstrated to prevent islet beta cell ... "Role of alpha beta receptor heterodimer formation in beta platelet-derived growth factor (PDGF) receptor activation by PDGF-AB" ... Two types of PDGFRs have been identified: alpha-type and beta-type PDGFRs.[8] The alpha type binds to PDGF-AA, PDGF-BB and PDGF ...

https://en.wikipedia.org/wiki/Platelet-derived_growth_factor

"Rapamycin potentiates transforming growth factor beta-induced growth arrest in nontransformed, oncogene-transformed, and human ...

https://en.wikipedia.org/wiki/P21

Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin ... phosphorylated region vital to beta-catenin binding and, therefore, to E-cadherin function.[citation needed] Beta-catenin can ... increases beta-catenin-E-cadherin association, and decreases beta-catenin-sensitive transcription". Cancer Research. 61 (4): ... "The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin". ...

https://en.wikipedia.org/wiki/CDH1_

RET is an abbreviation for "rearranged during transfection", as the DNA sequence of this gene was originally found to be rearranged within a 3T3 fibroblast cell line following its transfection with DNA taken from human lymphoma cells.[6] The human gene RET is localized to chromosome 10 (10q11.2) and contains 21 exons.[7] The natural alternative splicing of the RET gene results in the production of 3 different isoforms of the protein RET. RET51, RET43 and RET9 contain 51, 43 and 9 amino acids in their C-terminal tail respectively.[8] The biological roles of isoforms RET51 and RET9 are the most well studied in-vivo as these are the most common isoforms in which RET occurs. Common to each isoform is a domain structure. Each protein is divided into three domains: an N-terminal extracellular domain with four cadherin-like repeats and a cysteine-rich region, a hydrophobic transmembrane domain and a cytoplasmic tyrosine kinase domain, which is split by an insertion of 27 amino acids. Within the ...

https://en.wikipedia.org/wiki/RET_proto-oncogene

Wang P, Gao H, Ni Y, Wang B, Wu Y, Ji L, Qin L, Ma L, Pei G (February 2003). "Beta-arrestin 2 functions as a G-protein-coupled ... Wang P, Wu Y, Ge X, Ma L, Pei G (March 2003). "Subcellular localization of beta-arrestins is determined by their intact N ... In addition, MDM2 has p53-independent transcription factor-like effects in nuclear factor-kappa beta (NFκB) activation. ...

https://en.wikipedia.org/wiki/Mdm2

Tryptophan alpha,beta-oxidase. *Pyrroloquinoline-quinone synthase. *L-galactonolactone oxidase. 1.3.5: Quinone. *Succinate ...

https://en.wikipedia.org/wiki/SDHB

beta-catenin-TCF complex assembly. • transcription, DNA-templated. • transcription from RNA polymerase II promoter. • G1/S ... Feng XH, Liang YY, Liang M, Zhai W, Lin X (January 2002). "Direct interaction of c-Myc with Smad2 and Smad3 to inhibit TGF-beta ... "Mechanism for the transcriptional repression by c-Myc on PDGF beta-receptor". Journal of Cell Science. 114 (Pt 8): 1533-44. ...

https://en.wikipedia.org/wiki/C-myc

CTNNBL1: Beta-catenin-like protein 1. *DBNDD2: Dysbindin domain-containing protein 2 ...

https://en.wikipedia.org/wiki/Chromosome_20

"Beta-catenin--a linchpin in colorectal carcinogenesis?". The American Journal of Pathology. 160 (2): 389-401. doi:10.1016/s0002 ... regulates the stability of β-catenin in cytoplasm and subsequently, cytosolic β-catenin moves into the nucleus to facilitate ... Transgenic expression of a CD97 in mice enhanced levels of nonphosphorylated membrane-bound β-catenin and phosphorylated Akt.[ ... It has been shown that CD97 regulates localization and degradation of β-catenin.[24] GSK-3β, inhibited in some cancer, ...

https://en.wikipedia.org/wiki/CD97

... and stabilize beta-catenin.[20] Mutant of presenilin-1 that reduces the ability to stabilize beta-catenin complex leads to ... presenilin-1 was also found to play a role in beta-catenin phosphorylation.[21] Beta-catenin is coupled by presenilin-1 and ... "Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in ... beta-catenin binding. • protein binding. • calcium channel activity. • aspartic-type endopeptidase activity. • endopeptidase ...

https://en.wikipedia.org/wiki/PSEN1

... and hCGbeta transgenic female mice present with mammary Gland tumors exhibiting characteristics of the Wnt/beta-catenin pathway ... This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 5 subunit of chorionic gonadotropin ( ... The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and ... Chorionic gonadotropin, beta polypeptide 5 is a protein that in humans is encoded by the CGB5 gene. ...

https://en.wikipedia.org/wiki/CGB5

... a Drosophila protein that is homologous to mammalian beta-catenin Armadillo (C++ library), a software library for linear ...

https://en.wikipedia.org/wiki/Armadillo_(disambiguation)

The result is an uncontrolled production of beta-catenin, which regulates cell growth and cell mobility. With uncontrolled beta ... catenin, the cell loses its adhesive properties. As ECs get packed together to create the lining for a new blood vessel, a ...

https://en.wikipedia.org/wiki/Endothelial_stem_cell

连环蛋白（英语：Catenin）. *Alpha catenin. *Beta catenin *APC ...

https://zh.wikipedia.org/wiki/LMNA

"Identification of a Wnt/Dvl/beta-Catenin --, Pitx2 pathway mediating cell-type-specific proliferation during development.". ...

https://ar.wikipedia.org/wiki/PDLIM1

... nuclear translocation of androgen receptor complex with beta-catenin and T-cell factor 4 may bypass canonical Wnt signaling to ... increase beta adrenergic receptors while decreasing alpha adrenergic receptors- which results in increased levels of ... norepinephrine then acting on lipolysis-inducing beta receptors. ...

https://en.wikipedia.org/wiki/Androgen

Holmen SL, Robertson SA, Zylstra CR, Williams BO (2005). "Wnt-independent activation of beta-catenin mediated by a Dkk1-Fz5 ... "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals". Proc. Natl. Acad. Sci. U.S.A ... "Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin". Dev. Cell. 11 (2): 213-23 ... amyloid-beta binding. • signal transducer activity. • Wnt-protein binding. • protein binding. • protein kinase binding. • ...

https://en.wikipedia.org/wiki/FZD5

... enhances the Wnt/beta-catenin pathway by relieving antagonistic activity of Chibby". Cancer Research. 66 (2): 723-8. PMID ... correlates with Wnt/beta-catenin target genes and aggressive biological behavior in gastric cancer". Clinical Cancer Research. ... interaction with FGFR2 and beta-catenin signaling pathways". International Journal of Cancer. 121 (6): 1265-73. PMID 17520678. ...

https://ar.wikipedia.org/wiki/TCIM

Filamin B, beta (FLNB), also known as Filamin B, beta (actin binding protein 278), is a cytoplasmic protein which in humans is ... Catenins. *Alpha catenin. *Beta catenin *APC. *Plakoglobin (gamma catenin). *Delta catenin. *GAN ... Takafuta, T; Wu G; Murphy G F; Shapiro S S (Jul 1998). "Human beta-filamin is a new protein that interacts with the cytoplasmic ... Takafuta T, Wu G, Murphy GF, Shapiro SS (1998). "Human beta-filamin is a new protein that interacts with the cytoplasmic tail ...

https://en.wikipedia.org/wiki/FLNB

Catenins. *Alpha catenin. *Beta catenin *APC. *Plakoglobin (gamma catenin). *Delta catenin. *GAN ...

https://en.wikipedia.org/wiki/Wiskott-Aldrich_syndrome_protein

Catenins. *Alpha catenin. *Beta catenin *APC. *Plakoglobin (gamma catenin). *Delta catenin. *GAN ...

https://en.wikipedia.org/wiki/NFL_

... nuclear translocation of androgen receptor complex with beta-catenin and T-cell factor 4 may bypass canonical Wnt signaling to ...

https://sl.wikipedia.org/wiki/Androgen

Catenins. *Alpha catenin. *Beta catenin *APC. *Plakoglobin (gamma catenin). *Delta catenin. *GAN ...

https://en.wikipedia.org/wiki/Myofilament

... inhibits Wnt signaling by promoting TCF4 degradation and disrupting the TCF4/beta-catenin complex". Cellular Signalling. 22 (11 ... DVL is an integral part of the Wnt canonical pathway (β-catenin dependent) and non-canonical pathway (β-catenin-independent).[2 ... These regions mediate protein-protein interactions and help DVL channel signals into either the β-catenin or the β-catenin ... preventing constitutive degradation of β-catenin.[6][7] The prevention of this degradation DVL allows for β-catenin buildup in ...

https://en.wikipedia.org/wiki/Dishevelled

... β-catenin, RIP140, PCNA, the DNA metabolic enzymes flap endonuclease-1, thymine DNA glycosylase, and Werner syndrome DNA ... Beta-ketoacyl-ACP synthase. *Glyceronephosphate O-acyltransferase. *Lecithin-cholesterol acyltransferase. *Glycerol-3-phosphate ...

https://en.wikipedia.org/wiki/Histone_acetyltransferase

"Organized Emergence of Multiple-Generations of Teeth in Snakes Is Dysregulated by Activation of Wnt/Beta-Catenin Signalling". ...

https://en.m.wikipedia.org/wiki/Snake

... beta-catenin. It suggests that miR-181 may eradicate HCC. The increased expression of miR-181a in mature T cells increases ...

https://en.wikipedia.org/wiki/Mir-181_microRNA_precursor

"Liver-specific beta-catenin knockout mice exhibit defective bile acid and cholesterol homeostasis and increased susceptibility ...

https://gl.wikipedia.org/wiki/Colina

Roles for beta-catenin (part of the Wnt pathway) and appropriate levels of cell death of cortical progenitors have also been ...

https://en.wikipedia.org/wiki/Gyrification

"Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and beta-catenin". J. ... A novel multiple PSD-95/Dlg-A/ZO-1 protein interacting with neural plakophilin-related armadillo repeat protein/delta-catenin ... A novel multiple PSD-95/Dlg-A/ZO-1 protein interacting with neural plakophilin-related armadillo repeat protein/delta-catenin ... local control of RhoA at the cleavage furrow by the p0071 catenin". Cell Cycle. 6 (2): 122-7. doi:10.4161/cc.6.2.3741. PMID ...

https://en.wikipedia.org/wiki/PKP4

stimulates AC, raises cAMP, stimulates beta catenin and Glycogen synthase kinase 3 ...

https://en.wikipedia.org/wiki/Prostaglandin_receptor

... by c-Fos estrogen receptor activation involves nuclear translocation of beta-catenin and upregulation of beta-catenin/lymphoid ... Mohamed, O. A.; Clarke, H. J.; Dufort, D (2004). "Beta-catenin signaling marks the prospective site of primitive streak ... Other deficiencies in signaling pathways, such as in Nodal (a TGF-beta protein), will lead to defective mesoderm formation.[9] ... Both formation of the primitive streak and mesenchymal tissue is dependent on the Wnt/β-catenin pathway.[12] Specific markers ...

https://en.wikipedia.org/wiki/Mesenchyme

β-catenin-activated - with exon 3 versus exon 7/8 mutation. *β-Catenin-activated inflammatory - with exon 3 versus exon 7/8 ... as well as in beta-thalassemia and hemochromatosis.[2] ...

https://en.wikipedia.org/wiki/Hepatocellular_adenoma

Catenins. *Alpha catenin. *Beta catenin *APC. *Plakoglobin (gamma catenin). *Delta catenin. *GAN ... Sajid M, Hu Z, Lele M, Stouffer GA (May 2000). "Protein complexes involving alpha v beta 3 integrins, nonmuscle myosin heavy ...

https://en.wikipedia.org/wiki/MYH9

Catenins. *Alpha catenin. *Beta catenin *APC. *Plakoglobin (gamma catenin). *Delta catenin. *GAN ... The talin n-terminal head domain interacts with the membrane-proximal region of the beta(3) cytoplasmic tail". The Journal of ... Calderwood DA, Zent R, Grant R, Rees DJ, Hynes RO, Ginsberg MH (Oct 1999). "The Talin head domain binds to integrin beta ... in the talin rod domain is essential for linking integrin beta subunits to the cytoskeleton". The Journal of Biological ...

https://en.wikipedia.org/wiki/TLN1

"Activation of beta-catenin signalling by GSK-3 inhibition increases p-glycoprotein expression in brain endothelial cells". ... For example, PI3K/Akt pathway[18] and Wnt/ β-catenin pathway[20] were reported to positively regulate the expression of P-gp. ...

https://en.m.wikipedia.org/wiki/P-glycoprotein

Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin ... increases beta-catenin-E-cadherin association, and decreases beta-catenin-sensitive transcription". Cancer Res. 61 (4): 1671-7 ... "The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin". ... "A truncated beta-catenin disrupts the interaction between E-cadherin and alpha-catenin: a cause of loss of intercellular ...

https://gl.wikipedia.org/wiki/E-cadherina

If you know of any papers that use this antibody, please contact us at antibodies [at] alzforum [dot] org for consideration in the References section.. ...

https://www.alzforum.org/antibodies/beta-catenin-22

MCC inhibits beta-catenin transcriptional activity by sequestering DBC1 in the cytoplasm.. [Laurent Pangon, Dessislava ... In particular, the MCC protein is known to regulate beta-catenin (β-cat) signaling, but the mechanism is poorly understood. ...

https://www.sigmaaldrich.com/catalog/papers/24824780

Catenin beta-1. FLT3. cyclin-D1. BCL9. PLZF. SALL4. Junction plakoglobin. LEF. RARA. PML. Phosphate. Phosphate. GSK3B. RARA. ... Wnt/beta-catenin Signaling Pathway in Leukemia (Homo sapiens). From WikiPathways. Revision as of 14:19, 24 May 2018 by Mick ... Catenin beta-1. Protein. B4DGU4 (Uniprot-TrEMBL) DKK. GeneProduct. ENSG00000107984 (Ensembl) DKK Not Specified. ETO. ... The Wnt/Beta-catenin pathway mediates the transcription of proteins important for maintenance and growth of hematopoietic stem ...

https://www.wikipathways.org/index.php?title=Pathway:WP3658&oldid=97528&printable=yes

Furthermore, beta-catenin is expressed prior to the time at which MyoD transcripts can be detected. Expression of beta-catenin ... We show that chick frizzled 1 (Fz1), beta-catenin and Lef1 are expressed during somitogenesis. Lef1 and beta-catenin ... In somite explants, Fz1, beta-catenin and Lef1 are expressed prior to activation of myogenesis in response to Shh and Wnt ... Expression of (beta)-catenin in the developing chick myotome is regulated by myogenic signals ...

https://dev.biologists.org/content/127/19/4105?ijkey=f36815c6bc0d3c46e3d971f2b1774c9d9676e108&keytype2=tf_ipsecsha

In zebrafish, previous loss-of-function studies have not identified an essential role for beta-catenin in dorsal axis ... Wnt signals and their transcriptional effector beta-catenin are required for the development of dorsal axial structures. ... MOs directed against beta-catenin-1 (MO1), by contrast, had no ventralizing effect on wild-type embryos. beta-catenin-2 is thus ... Although the ichabod mutation does not functionally alter the beta-catenin-2 reading frame, the level of maternal beta-catenin- ...

http://www.biomedsearch.com/nih/Essential-opposing-roles-zebrafish-beta/16510506.html

1. What happens when you deplete beta catenin in planarians? -The organism is no longer able to form a posterior side ... remember that all hosts above are treated with beta-catenin RNAi). Neoblast Donor Host Treatment Predicted Phenotype Beta ... You want to know which cell types in a planaria require beta-catenin for post-injury axial determination. Specifically, is beta ... 1. What happens when you deplete beta catenin in planarians? -The organism is no longer able to form a posterior side when it ...

https://www.coursehero.com/file/6871102/2011-Questions-Week-14-Answers/

... beta and gamma catenin. Beta-catenin links this complex through alpha-actinin to the cytoskeleton. Functional cadherin-catenin ... Beta-catenin level in cytoplasm is controlled by glycogen synthase kinase-3 beta. When activity of this kinase is blocked (e.g ... Mouse Monoclonal to beta-Catenin. EM-22 (IgG1). Technical Information Request Inquiry for Bulk Prices. ... 3. Flow cytometry analysis (intracellular) of beta-catenin in human MCF-7 cell line by EM-22-Alexa Fluor® 488 (red) compared to ...

http://www.exbio.cz/products/clone.py?idclone=CLO000000000000375

Intramyocellular lipid accumulation is related to the down-regulation of Wnt-beta-catenin pathway. Metabolic Syndrome is a ... Six homeoproteins and Wnt-beta-catenin pathway in muscle development and disease * Tweeter ... Six homeoproteins and Wnt-beta-catenin pathway in muscle development and disease ... we plan to determine whether activation of the Wnt-beta-catenin pathway could maintain muscle satellite cells in the myoblastic ...

https://www.institutcochin.fr/departments/drc/team-maire-sotiropoulos/fonction-des-homeoproteines-six-et-de-leurs

Unconjugated beta Catenin, clone: 15B8, eBioscience™ Primary Antibodies Cas to Caz ... Description: The 15B8 monoclonal antibody reacts with human and mouse beta-catenin, one member of a family of catenins, which ... The Wnt and beta-catenin signaling pathway has been demonstrated to play a crucial role in the development of T, B, and ... More specifically, beta-catenin binds to the cytoplasmic tail of E-cadherin. In addition, this molecule is a component of the ...

https://www.fishersci.co.uk/shop/products/beta-catenin-mouse-anti-human-mouse-clone-15b8-ebioscience-2/15257327

Most studies investigating catenin actions focus on alpha catenin and beta catenin. Beta catenin is particularly interesting as ... It belongs to a family of biological compounds known as catenins, consisting of alpha catenin, beta catenin and gamma catenin. ... ROLE OF BETA CATENIN IN THE DEVELOPMENT OF CANCERS:. The same properties of beta catenin that give it an important role in ... Wnt/ beta catenin pathway, also known as canonical Wnt pathway is the Wnt pathway that causes an accumulation of beta catenin ...

https://dialecticalhomeopathy.wordpress.com/2015/12/11/molecular-imprints-of-beta-catenin-a-highly-promising-homeopathic-weapon-in-the-fight-against-cancers-2/

Catenin References *↑ Daniels DL, Weis WI. ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the ... an inhibitor of beta-catenin-mediated transcription, bound to the armadillo repeat domain of beta-catenin, has been determined ... The C-terminal armadillo repeats of beta-catenin may be an attractive target for compounds designed to disrupt aberrant beta- ... catenin-mediated transcription associated with various cancers. ICAT inhibits beta-catenin binding to Tcf/Lef-family ...

http://proteopedia.org/wiki/index.php/1m1e

... and to determine whether aberrant beta-catenin expression is driven by CTNNB1 (beta-catenin encoding gene) activating mutations ... of the cases displayed lack/reduction of beta-catenin membranous expression and nuclear accumulation. Complete lack of beta- ... beta-Catenin pathway activation in breast cancer is associated with triple-negative phenotype but not with CTNNB1 mutation ... The association of beta-catenin/Wnt pathway activation with clinical outcome and the mechanisms leading to its activation in ...

http://publications.icr.ac.uk/10393/

... beta 1 (88kD); Catenin beta; Catnb; Ctnnb; CTNNB1 Beta-catenin (β-catenin) (Armadillo in Drosophila) is a multifunctional ... Catenin (cadherin-associated protein), beta 1 (88kD); Catenin beta; Catnb; Ctnnb; CTNNB1 ... Beta-catenin (β-catenin) (Armadillo in Drosophila) is a multifunctional protein involved in two essential cellular events: cell ... Clevers H. Wnt/beta-catenin signaling in development and disease. Cell. 2006;127:469-80.PubMedPubMedCentralCrossRefGoogle ...

https://link.springer.com/referenceworkentry/10.1007%2F978-3-319-67199-4_528

Beta-catenin (IPR013284). Short name: Beta-catenin Family relationships *Beta-catenin (IPR013284) *Junction plakoglobin/protein ... Beta-catenin forms a cadherin/beta-catenin/alphaE-catenin complex that can tether the tripartite adhesion complex and regulate ... The beta-catenin structure has been determined [PMID: 9298899, PMID: 11136974]. Beta catenin family proteins contain several ... The armadillo homologs beta-catenin and plakoglobin are differentially expressed during early development of Xenopus laevis.. ...

http://www.ebi.ac.uk/interpro/entry/IPR013284

InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.

http://www.ebi.ac.uk/interpro/protein/Q02248

The degree to which beta-catenin participates in these two functions is dictated by the availability of beta-catenin binding ... Beta-catenin plays a critical structural role in cadherin-based adhesions and is also an essential co-activator of Wnt-mediated ... Phospho-regulation of Beta-catenin adhesion and signaling functions.. Daugherty RL1, Gottardi CJ. ... Inputs from various cell-signaling events can therefore impact beta-catenin function, which may be necessary for the finely ...

https://www.ncbi.nlm.nih.gov/pubmed/17928543?dopt=Abstract

Genomic organization of the human beta-catenin gene (CTNNB1).. Nollet F1, Berx G, Molemans F, van Roy F. ... The cytoplasmic beta-catenin protein is implicated in signal transduction and associates with both the cell-cell adhesion ... We determined the primary structure of the human beta-catenin gene (CTNNB1) by analysis of cDNA and genomic clones. The size of ... The intron-exon boundaries did not coincide either with conserved sites in the 12 armadillo repeat sequences of beta-catenin or ...

https://www.ncbi.nlm.nih.gov/pubmed/8838805?dopt=Abstract

... have discovered that a single mutation in the beta-catenin gene, which codes a protein known to be deeply involved in a number ... Beta-catenin is an essential protein in the Wnt/beta-catenin signaling pathway, which has been shown in mice to be involved in ... developed a mouse with single mutation to the beta-catenin gene, with the goal to discover so far unrevealed functions of beta- ... "A single mutation in the beta-catenin gene can lead to infertility." Medical News Today. MediLexicon, Intl., 10 Nov. 2014. Web. ...

https://www.medicalnewstoday.com/releases/285136.php

Beta-catenin is also involved in the regulation of gene expression as a mediator of the Wnt signaling pathway. The expression ... and intracellular localization of beta-catenin is altered in many types of cancers. ... Beta-catenin is an 88 kDa multifunctional protein playing an essential role in cell-cell adhesion by binding to the ... Clone β-Catenin-1 Beta-catenin is an 88 kDa multifunctional protein playing an essential role in cell-cell adhesion by binding ...

https://www.agilent.com/en/product/immunohistochemistry/antibodies-controls/primary-antibodies/beta-catenin-

The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin. ... BETA-CATENIN A, C 538 Mus musculus Fragment: ARMADILLO DOMAIN Gene Name(s): Ctnnb1 Catnb ...

http://www.rcsb.org/pdb/explore/litView.do?structureId=1I7X

Loss of functional APC protein results in the accumulation of beta-catenin. Mutant forms of beta-catenin have been discovered ... Loss of functional APC protein results in the accumulation of beta-catenin. Mutant forms of beta-catenin have been discovered ... with which beta-catenin interacts. Here we show that beta-catenin activates transcription from the cyclin D1 promoter, and that ... Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells Nature. 1999 Apr 1;398(6726):422-6. doi: 10.1038/18884 ...

https://pubmed.ncbi.nlm.nih.gov/10201372/?dopt=Abstract

... beta-catenin-TCF7L2 complex, catenin complex, cell cortex, cell junction, cell periphery, cell-cell adherens junction, cell- ... R-SSC-195253. Degradation of beta-catenin by the destruction complex. R-SSC-196299. Beta-catenin phosphorylation cascade. R-SSC ... R-SSC-195253. Degradation of beta-catenin by the destruction complex. R-SSC-196299. Beta-catenin phosphorylation cascade. R-SSC ... Beta-cateninImported. ,p>Information which has been imported from another database using automatic procedures.,/p> ,p>,a href ...

http://www.uniprot.org/uniprot/Q8WNW4

Gene ablation and transgenic expression studies strongly support the concept that beta-catenin together with Lef/Tcf factors ... Beta-catenin regulates cell-cell adhesion and transduces signals from many pathways to regulate the transcriptional activities ... Stabilized beta-catenin induces hyperplasia and mammary tumors in mice. Each of the beta-catenin-induced phenotypes is ... Beta-catenin and Tcfs in mammary development and cancer J Mammary Gland Biol Neoplasia. 2003 Apr;8(2):145-58. doi: 10.1023/a: ...

https://pubmed.ncbi.nlm.nih.gov/14635791/?dopt=Abstract

Michael Davidsons lab contains the insert Beta-Catenin. This plasmid is available through Addgene. ... mEmerald-Beta-Catenin-20 was a gift from Michael Davidson (Addgene plasmid # 54017 ; http://n2t.net/addgene:54017 ; RRID: ...

https://www.addgene.org/54017/

Catenin beta-1Imported. ,p>Information which has been imported from another database using automatic procedures.,/p> ,p>,a href ... tr,D3YUH4,D3YUH4_MOUSE Catenin beta-1 (Fragment) OS=Mus musculus GN=Ctnnb1 PE=1 SV=1 ...

http://www.uniprot.org/uniprot/D3YUH4

... for Anti-beta Catenin antibody [E247] used in Immunocytochemistry/ Immunofluorescence. Abcam provides excellent in-house ...

https://www.abcam.com/beta-catenin-antibody-e247-ab32572/reviews/43313

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1997 ) -catenin is a target for the ubiquitin-proteasome pathway. (biologists.org)
Intramyocellular lipid accumulation is related to the down-regulation of Wnt-beta-catenin pathway. (institutcochin.fr)
As Wnt-10b and SREBP-1c proteins showed an inverse expression profile throughout differentiation in cultured satellite cells, we plan to determine whether activation of the Wnt-beta-catenin pathway could maintain muscle satellite cells in the myoblastic lineage, preventing them from expressing adipogenic factors that induce lipid synthesis in skeletal muscle. (institutcochin.fr)
Investigation of SREBP-1c regulation by the Wnt-catenin pathway should provide new insights into muscle insulin resistance and open perspectives for the unravelling of cellular mechanisms involved in ectopic lipid deposition in skeletal muscle during obesity and type 2 diabetes. (institutcochin.fr)
The Wnt and beta-catenin signaling pathway has been demonstrated to play a crucial role in the development of T, B, and hematopoietic stem cells.Applications Reported: This 15B8 antibody has been reported for use in intracellular staining followed by flow cytometric analysis, immunoprecipitation, western blotting, and immunohistochemical staining of formalin-fixed paraffin embedded tissue sections. (fishersci.co.uk)
β-catenin is a subunit of the cadherin protein complex and acts as an intracellular signal transducer in the Wnt signaling pathway. (wordpress.com)
Secondly, beta catenin participates in the 'Wnt signaling pathway' as a downstream target. (wordpress.com)
Wnt/ beta catenin pathway, also known as canonical Wnt pathway is the Wnt pathway that causes an accumulation of beta catenin in the cytoplasm and its eventual translocation into the nucleus to act as a transcriptional coactivator of transcription factors that belong to the TCF/LEF family. (wordpress.com)
In general, when 'Wnt' is not present, GSK-3B (a member of the pathway) is able to phosphorylate beta catenin as a result of a complex formation that includes beta catenin, AXIN1, AXIN2, APC (a tumor suppressor gene product), CSNK1A1, and GSK3B. (wordpress.com)

In particular, the MCC protein is known to regulate beta-catenin (β-cat) signaling, but the mechanism is poorly understood. (sigmaaldrich.com)
BETA CATENIN is a protein found as part of molecular complexes in forming cadherin cell adhesion factors of animal cells. (wordpress.com)
BETA CATENIN is a dual function protein, regulating the coordination of cell-cell adhesion and gene transcription. (wordpress.com)
This protein promotes the assembly of a multiprotein complex that recruits and phosphorylates the Wnt effector beta-catenin and targets beta-catenin for ubiquitylation and proteasomal degradation. (nih.gov)
This protein therefore plays a role in the reduction of cytoplasmic levels of beta-catenin which in turn reduces activation of Wnt target genes that play a pivotal role in the pathogenesis of various human cancers. (nih.gov)

It belongs to a family of biological compounds known as catenins, consisting of alpha catenin, beta catenin and gamma catenin. (wordpress.com)

These complexes, which help regulate cell growth in addition to creating and maintaining epithelial layers, are known as 'adherens junctions' and they typically include at least cadherin, beta catenin, and alpha catenin. (wordpress.com)
Most studies investigating catenin actions focus on alpha catenin and beta catenin. (wordpress.com)

Description: The 15B8 monoclonal antibody reacts with human and mouse beta-catenin, one member of a family of catenins, which are intracellular proteins that interact with cadherins to mediate cellular adhesion. (fishersci.co.uk)

B-CATENIN binds the cytoplasmic domain of some cadherins. (wordpress.com)
Catenins play roles in cellular organization and polarity long before the development and incorporation of 'Wnt signaling pathways' and cadherins. (wordpress.com)
The primary mechanical role of catenins is connecting cadherins to actin filaments, specifically in these adhesion junctions of epithelial cells. (wordpress.com)

Expression of beta-catenin mRNA is regulated by positive and negative signals derived from neural tube, notochord and lateral plate mesoderm. (biologists.org)
Upon Wnt binding, beta-catenin becomes dephosphorylated, translocates to the nucleus, and modulates gene expression in partnership with the transcription factors T cell factor (TCF) and lymphocyte enhancer binding factor (LEF). (fishersci.co.uk)
Expression of beta-catenin is found in a wide variety of non-immune and immune tissues, including thymocytes and T and B lymphocytes. (fishersci.co.uk)

1994 ) -catenin localization during Xenopus embryogenesis-accumulation at tissue and somite boundaries. (biologists.org)

No, Beta-catenin is the downstream transcriptional effector of the Wnt ligand. (coursehero.com)

MCC inhibits beta-catenin transcriptional activity by sequestering DBC1 in the cytoplasm. (sigmaaldrich.com)

1996 ) Functional interaction of-catenin with the transcription factor Lef-1. (biologists.org)

Beta catenin acts basically by anchoring the actin cytoskeleton to the adherens junctions, and also aid in contact inhibition signaling within the cell. (wordpress.com)
Without Wnt signaling, the beta catenin would not accumulate in the cytoplasm since a destruction complex would normally degrade it. (wordpress.com)

More specifically, beta-catenin binds to the cytoplasmic tail of E-cadherin. (fishersci.co.uk)

In the absence of Wnt binding its receptor, beta-catenin is phosphorylated and resides in the cytoplasm where it is eventually targeted for degradation by ubiquitination. (fishersci.co.uk)

3. You want to know which cell types in a planaria require beta-catenin for post-injury axial determination. (coursehero.com)

Their attempts have not been so far successful, since any chemical compound they develop to target BETA CATENIN will inevitably have serious harmful effects upon the organism, since it is an essential biological molecule having diverse roles normal vital processes, and its complete inhibition may lead to be very dangerous consequences. (wordpress.com)

If planarians were to specifically required beta-catenin in neoblasts for posterior determination, fill out the predicted phenotypes for these experiments (remember that all hosts above are treated with beta-catenin RNAi). (coursehero.com)

You perform the following experiments on hosts that are all irradiated and treated with Beta-catenin RNAi, cutting out a middle segment from each experimental set to assay its ability to regenerate. (coursehero.com)

They have been trying to develop drugs that could inhibit the over-expressions and aberrations of BETA CATENIN, which is recognized to be playing a big role in the biochemical processes underlying various types of cancers. (wordpress.com)

Thus, Wnt1 could act through beta-catenin on cells in the myotome. (biologists.org)
Specifically, is beta-catenin required in neoblasts, non-neoblasts, or all planarian cells? (coursehero.com)
For instance, when an epithelial layer is complete and the adherens junctions indicate that the cell is completely surrounded, beta catenin may play a role in telling the cell to stop proliferating, as there is no room for more cells in the area. (wordpress.com)

α-catenin binds to β-catenin in the nucleus, preventing it from regulating transcription, and levels of both proteins appear to be regulated via proteasome-dependent degradation (4). (cellsignal.com)
The cytoplasmatic tail of the E-cadherin molecule binds to the proteins of the catenin family: p120-catenin, beta-catenin, and beta-catenin. (redorbit.com)
The distinct peripheral cytosolic proteins, alpha, beta and gamma-catenin (102, 94 and 86 kD) found in many tissues (1,2,3) bind to the conserved cytoplasmic tail domain of the cell-adhesion cadherins. (genetex.com)
Catenins link E-cadherin to other integral membrane or cytoplasmic proteins and are modulated by Wnt-1 proto-oncogene. (genetex.com)
Addgene: Transformation by Wnt family proteins correlates with regulation of beta-catenin. (addgene.org)
In addition, we engineered intracellularly functional anti-β-catenin chromobodies by combining the binding moieties of the nanobodies with fluorescent proteins. (mcponline.org)
The catenins, (alpha, beta and gamma) are cytoplasmic proteins which bind to the highly conserved tail of the E-cadherin molecule. (leicabiosystems.com)
Here we find that, in colorectal cancer cells and in developing mouse forelimbs, BCL9 proteins sustain the action of beta-catenin in a largely PYGO-independent manner. (epfl.ch)
Expression and purification of human β-catenin-MBP fusion proteins. (genscript.com)
Affinity purification and mass spectrometry were used to identify potential β-catenin interacting proteins in SW480 colon cancer cells. (genscript.com)
Recombinant β-catenin constructs were used to co-isolate interacting proteins from stable isotope labelled cells followed by detection using mass spectrometry. (genscript.com)
In this study, we demonstrated that the function of E-cadherin was completely abolished in the human gastric cancer cell line HSC-39, despite the high expression of E-cadherin, because of mutations in one of the E-cadherin-associated cytoplasmic proteins, beta-catenin. (asm.org)
E-cadherin and beta-catenin are key proteins that are essential in the formation of the epithelial cell layer in the colon but their regulatory pathways that are disrupted in cancer metastasis are not completely understood. (garvan.org.au)
ß-catenin is part of a complex of proteins that form adherens junctions, which are important for the establishment and maintenance of epithelial cell layers by regulating cell growth and adhesion between adjacent cells ( Hartsock and Nelson 2008 ). (mycancergenome.org)
We have examined Wnt-1 function in mammalian cells in which armadillo (beta-catenin and plakoglobin) is known to bind to and regulate cadherin cell adhesion proteins. (rupress.org)
The interaction of beta-catenin and LRRFIP1 was also reported for human proteins when they were co-expressed in human embryonic kidney 293T (HEK293T) cells followed by co-immunoprecipitation assay. (reactome.org)
BACKGROUND: Wnt signaling is thought to be important in prostate cancer, in part because proteins such as beta-catenin can also affect androgen receptor signaling. (ox.ac.uk)

Three different forms of catenin (designated alpha, beta and gamma) comprise the cytoplasmic domain of the cadherin cell-cell adhesion complex [ PMID: 7945318 ]. (ebi.ac.uk)
On the cytoplasmic side of adherens junctions, the classic model states that cadherins are linked to the cytoskeleton through β- and α-catenin. (cellsignal.com)
The cytoplasmic domain of classical cadherins interacts with β-catenin, γ-catenin (also called plakoglobin), and p120 catenin. (cellsignal.com)
Beta-catenin binds directly to the cytoplasmic tail of E-cadherin. (genetex.com)
Beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. (genetex.com)
However, in lobular neoplasia, a marked redistribution of beta-catenin throughout the cytoplasm results in a diffuse cytoplasmic pattern. (genetex.com)
Additionally, some rectal and gastric adenocarcinomas demonstrate diffuse cytoplasmic beta-catenin staining and a lack of membranous staining, mimicking the staining pattern observed with lobular breast carcinomas. (genetex.com)
Cytoplasmic localization of β-Catenin has been demonstrated as a marker of poor outcome in breast cancer patients. (biocare.net)
Calcium-dependent intercellular adhesion transmembrane glycoprotein E-cadherin interacts by its cytoplasmic domain with reciprocally bound alpha, beta and gamma catenin. (exbio.cz)
We show that RET binds to, and tyrosine phosphorylates, beta-catenin and show that the interaction between RET and beta-catenin can be direct and independent of cytoplasmic kinases, such as SRC. (metabolomicscentre.nl)

In U87 cell line, inhibition of β-catenin by siRNA suppressed EGF-induced proliferation, migration, invasiveness, and the expression of EMT activators (Snail and Slug). (dovepress.com)
These findings provide evidence that SS induces apoptosis of breast tumor cells through a mechanism involving inhibition of PDE5 and attenuation of oncogenic Wnt/beta-catenin mediated transcription. (aacrjournals.org)
β-Catenin inhibition by either small molecule inhibitors or siRNA resulted in a dose-dependent increase of cell proliferation, whereas β-Catenin activation by Wnt-3a had the opposite effects, resulting in a decrease in cell viability. (bu.edu)

The armadillo homologs beta-catenin and plakoglobin are differentially expressed during early development of Xenopus laevis. (ebi.ac.uk)
Beta-catenin and plakoglobin expressi. (ugent.be)
Verstraeten B, van Hengel J, Huysseune A. Beta-catenin and plakoglobin expression during zebrafish tooth development and replacement. (ugent.be)
We show that Wnt-1 expression results in the accumulation of beta-catenin and plakoglobin. (rupress.org)

The degree to which beta-catenin participates in these two functions is dictated by the availability of beta-catenin binding partners, and an emerging theme is that these binding interactions are regulated by phosphorylation. (nih.gov)
IWP-2 blocks Wnt-dependent phosphorylation of Lrp6 receptor and Dvl2, and β-catenin accumulation. (selleckchem.com)
Tcf3 is a substrate for both glycogen synthase kinase (GSK) 3 and casein kinase (CK) 1epsilon, and phosphorylation of Tcf3 by CKIepsilon stimulates its binding to beta-catenin, an effect reversed by GSK3 . (xenbase.org)
Tcf3 blocks β-catenin degradation in extracts and phosphorylation in vitro. (xenbase.org)
D) Tcf3 inhibits the phosphorylation of β-catenin by GSK3 and axin in a purified system. (xenbase.org)
This prevents phosphorylation of downstream molecules allowing β-catenin association with Tcf/Lef in the nucleus and subsequent increased cell proliferation. (springermedizin.de)
As a result of RET -mediated tyrosine phosphorylation, beta-catenin escapes cytosolic down-regulation by the adenomatous polyposis coli/Axin/glycogen synthase kinase-3 complex and accumulates in the nucleus, where it can stimulate beta-catenin-specific transcriptional programs in a RET -dependent fashion. (metabolomicscentre.nl)

2018) Beta-Catenin. (springer.com)
The report then estimates 2018-2023 market development trends of Beta Catenin industry. (reportsnreports.com)
and Barrett, Terrence A., "Beta-Catenin Cleavage Enhances Transcriptional Activation" (2018). (uky.edu)
Catenin Beta 1 - Pipeline Review, H1 2018, outlays comprehensive information on the Catenin Beta 1 targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type. (whatech.com)

Here we show that beta-catenin activates transcription from the cyclin D1 promoter, and that sequences within the promoter that are related to consensus TCF/LEF-binding sites are necessary for activation. (nih.gov)
We showed that zygotic transcription of beta-catenin starts after the midblastula transition (MBT), but does not rescue dorsal axial structures. (biologists.org)
1996 ) Functional interaction of-catenin with the transcription factor Lef-1. (biologists.org)
Lymphoid enhancer binding factor (Lef) 1 is a Wnt-responsive transcription factor that associates with β-catenin. (asbmr.org)
We identified the transcription factor TBX3 as a candidate tissue-specific member of the beta-catenin transcriptional complex. (epfl.ch)
Here, we provide evidence that HIC1 antagonizes the TCF/beta-catenin-mediated transcription in Wnt-stimulated cells. (muni.cz)
5 Here, we further investigated the ability of AIEC to activate Wnt transcription and nuclear translocation of b-catenin. (bmj.com)
ß-catenin is then free to translocate to the cell nucleus where it acts as a co-factor for the T-cell factor/lymphoid enhancing factor (TCF/LEF) transcription factors. (mycancergenome.org)
ß-catenin subsequently translocates to the nucleus, where it acts as a co-factor for the TCF/LEF family of transcription factors. (mycancergenome.org)
Suppression of PDE5 with siRNA or known PDE5 inhibitors was sufficient to selectively induce apoptosis and attenuate beta-catenin mediated transcription in breast tumor cells with minimal effects on normal mammary epithelial cells. (aacrjournals.org)

Three-dimensional structure of the armadillo repeat region of beta-catenin. (ebi.ac.uk)
12) The central core region of beta-catenin is involved in mediation of cadherin-catenin complex interaction with EGFR. (genetex.com)

E- cadherins bind to beta-catenin to form a complex which can interact both with neighboring cells to form bonds, and with the cytoskeleton of the cell. (redorbit.com)

Mechanistically, we establish that MCC interacts with the E-cadherin/beta-catenin complex. (garvan.org.au)

A pathological role of beta-catenin has been identified in pilomatrixoma (PTR), medulloblastoma (MDB), colorectal cancer (CRC), ovarian cancer, and tumor development. (thermofisher.com)
Studies from our group indicate that β-catenin activation in colitis and colorectal cancer (CRC) correlates with increased nuclear levels of β-catenin phosphorylated at serine 552 (pβ-Cat 552 ). (uky.edu)

Abnormal levels of beta-catenin may therefore contribute to neoplastic transformation by causing accumulation of cyclin D1. (nih.gov)
Moreover, the chromobody signal allowed us to trace the accumulation of diffusible, hypo-phosphorylated β-catenin in response to compound treatment in real time using High Content Imaging. (mcponline.org)
1994 ) -catenin localization during Xenopus embryogenesis-accumulation at tissue and somite boundaries. (biologists.org)
In zebrafish, previous loss-of-function studies have not identified an essential role for beta-catenin in dorsal axis formation, but the maternal-effect mutation ichabod disrupts beta-catenin accumulation in dorsal nuclei and leads to a reduction of dorsoanterior derivatives. (biomedsearch.com)
Immunolabeling for β-catenin confirmed the presence of abnormal nuclear accumulation in SSAs, with 35/54 (67%) SSAs showing nuclear labeling compared to 0/12 hyperplastic polyps (HPs). (pubmedcentralcanada.ca)

In Xenopus, Wnt signals and their transcriptional effector beta-catenin are required for the development of dorsal axial structures. (biomedsearch.com)

Specificity Recognizes human Catenin, beta. (gentaur.com)

Here we investigated, firstly, the role(s) of beta-catenin in spatial terms, in different regions of the embryo, by injecting beta-catenin mRNA into individual blastomeres of beta-catenin-depleted embryos at the 32 cell stage. (biologists.org)

Overexpressed in vitro double truncated β-catenin increased transcriptional activity, cell proliferation and growth of tumor xenografts compared to FS β-catenin. (uky.edu)

Crystal structure of a beta-catenin/Tcf complex. (ebi.ac.uk)
D) Half-life of the axin-β-catenin complex. (xenbase.org)
Our work implicates TBX3 as context-dependent component of the Wnt/beta-catenin-dependent transcriptional complex. (epfl.ch)
In particular, we identified interaction with a set of coatomer complex I subunits implicated in retrograde transport at the Golgi, and confirmed endogenous interaction of β-catenin with coatomer subunit COPB using immunoprecipitation assays and immunofluorescence microscopy. (genscript.com)
The GL treatment resulted in a significant reduction of β-Catenin /TCF-4 complex in both of the cancer cells. (biomedcentral.com)
The disruption of E-cadherin/beta-catenin complex formation promotes EMT, thereby stimulating tumor progression. (ox.ac.uk)

For the first time, we were able to visualize the subcellular localization and nuclear translocation of endogenous β-catenin in living cells using these chromobodies. (mcponline.org)
Nuclear translocation of b-catenin was assessed by immunofluorescence in CRC cell-lines SW480 and DLD1. (bmj.com)
Infection of SW480 and DLD1 showed significant increases in b -catenin nuclear translocation as per prostaglandin E2 treatment (1-10 μM). (bmj.com)
alanin substitution abrogated K48 polyubiquitination, β-catenin nuclear translocation and tumor xenograft growth. (uky.edu)

We selected nanobodies recognizing the N-terminal, core or C-terminal domain of β-catenin and applied these new high-affinity binders as capture molecules in sandwich immunoassays and co-immunoprecipitations of endogenous β-catenin complexes. (mcponline.org)

Heteroduplex was used to investigate mutations in beta-catenin. (mdpi.com)

The results indicate that beta-catenin can rescue the dorsal axial structures in a non-cell-autonomous way and without changing the fates of the injected cells. (biologists.org)

2001), Physiological regulation of [beta]-catenin stab. (xenbase.org)
Physiological regulation of [beta]-catenin stability by Tcf3 and CK1epsilon . (xenbase.org)
We show that down-regulation of beta-catenin activity decreases RET -mediated cell proliferation, colony formation, and tumor growth in nude mice. (metabolomicscentre.nl)

E7386 disrupted the interaction between beta-catenin and CBP in co-immunoprecipitation assay. (aacrjournals.org)

The 79-kDa band was immunologically identified as beta-catenin by using immunoblotting with anti-beta-catenin antibodies. (asm.org)

We demonstrate that Tcf3 can inhibit beta-catenin turnover via its competition with axin and adenomatous polyposis for beta-catenin binding. (xenbase.org)

The distribution of Wnt2 and beta-catenin in rat corneas was examined by Immunofluorescence staining. (arvojournals.org)

To date, β-catenin has been reported to be implicated in mediating the epithelial-mesenchymal transition (EMT) in a variety of human cancers, which can be triggered by EGF. (dovepress.com)
When SSAs were further analyzed with respect to the presence or absence of conventional epithelial dysplasia, nuclear β-catenin labeling was seen in 8/27 (29%) SSAs without dysplasia (SSA) but in 27/27 (100%) of SSAs with dysplasia (SSADs) (p=0.000001). (pubmedcentralcanada.ca)

Takemaru K-I, Ohmitsu M, Li F-Q. An oncogenic hub: beta-catenin as a molecular target for cancer therapeutics. (springer.com)
Molecular cloning reveals alternative splice forms of human alpha(E)-catenin. (ebi.ac.uk)
Together, this data demonstrates that the disruption of cadherin-beta-catenin complexes is an important molecular event through which BDNF increases synapse density in cultured hippocampal neurons. (escholarship.org)
Biochemical analysis of nuclear extracts from cancer biopsies revealed the existence of low molecular weight (LMW) pβ-Cat 552 , increased to the exclusion of full size (FS) forms of β-catenin. (uky.edu)

The different tasks of β-catenin are orchestrated by its subcellular localization and participation in multiprotein complexes. (mcponline.org)
Artificially maintaining cadherin-beta-catenin complexes in the presence of BDNF abolishes the BDNF-mediated enhancement of synaptic vesicle mobility, as well as the longer-term BDNF-mediated increase in synapse number. (escholarship.org)

Grigoryan T, Wend P, Klaus A, Birchmeier W. Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of beta-catenin in mice. (springer.com)

Anatomy10

Diseases6

Chemicals and Drugs44

Analytical, Diagnostic and Therapeutic Techniques and Equipment7

Phenomena and Processes10

Disciplines and Occupations1

Information Science2

Alzheimer's disease: clues from flies and worms. (1/5919)

The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin. (2/5919)

Axin prevents Wnt-3a-induced accumulation of beta-catenin. (3/5919)

Glucocorticoid down-regulation of fascin protein expression is required for the steroid-induced formation of tight junctions and cell-cell interactions in rat mammary epithelial tumor cells. (4/5919)

Frequent nuclear/cytoplasmic localization of beta-catenin without exon 3 mutations in malignant melanoma. (5/5919)

Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway. (6/5919)

Cadherin-11 is expressed in invasive breast cancer cell lines. (7/5919)

Coupling assembly of the E-cadherin/beta-catenin complex to efficient endoplasmic reticulum exit and basal-lateral membrane targeting of E-cadherin in polarized MDCK cells. (8/5919)

beta Catenin

Catenins

alpha Catenin

Cytoskeletal Proteins

Cadherins

Intestinal Polyps

Trans-Activators

Axin Signaling Complex

gamma Catenin

Peutz-Jeghers Syndrome

Wnt Proteins

Wilms Tumor

Adenomatous Polyposis Coli

Desmoplakins

Tumor Markers, Biological

Interleukin-1beta

Signal Transduction

Cell Nucleus

Adherens Junctions

Neoplasm Proteins

Cytoplasm

Immunoenzyme Techniques

Cell Adhesion Molecules

beta 2-Microglobulin

Immunohistochemistry

Colorectal Neoplasms

Cell Adhesion

Adenocarcinoma

Phosphoproteins

Receptors, Adrenergic, beta

Integrin beta3

Prognosis

Transforming Growth Factor beta

Armadillo Domain Proteins

Cell Line

Desmosomal Cadherins

Cells, Cultured

Intercellular Junctions

Integrin alpha5beta1

Glycogen Synthase Kinase 3

Integrin beta4

Integrin alpha6beta4

Integrin beta Chains

beta 2-Glycoprotein I

Integrin alpha4beta1

Phosphorylation

Integrin alpha2beta1

Receptors, Adrenergic, beta-2

rhoA GTP-Binding Protein

Transfection

RNA, Messenger

rac1 GTP-Binding Protein

Precipitin Tests

Blotting, Western

Protein Transport

Integrins

Interleukin-1

Antigens, CD29

Molecular Sequence Data

Integrin alpha6beta1

Cell Movement

Base Sequence

Epithelial Cells

Protein Binding

Receptors, Adrenergic, beta-1

Desmogleins

Fluorescent Antibody Technique

Mutation

Integrin alpha1beta1

Blood-Air Barrier

Binding Sites

rho GTP-Binding Proteins

Axin Protein

Recombinant Proteins

Recombinant Fusion Proteins

Cell Line, Tumor

Cytoskeleton

Alzheimer's disease: clues from flies and worms. (1/5919)

The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin. (2/5919)

Axin prevents Wnt-3a-induced accumulation of beta-catenin. (3/5919)