Beta catenin. Medical search

A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS.

A family of cytoskeletal proteins that play essential roles in CELL ADHESION at ADHERENS JUNCTIONS by linking CADHERINS to the ACTIN FILAMENTS of the CYTOSKELETON.

A catenin that binds F-ACTIN and links the CYTOSKELETON with BETA CATENIN and GAMMA CATENIN.

Major constituent of the cytoskeleton found in the cytoplasm of eukaryotic cells. They form a flexible framework for the cell, provide attachment points for organelles and formed bodies, and make communication between parts of the cell possible.

Calcium-dependent cell adhesion proteins. They are important in the formation of ADHERENS JUNCTIONS between cells. Cadherins are classified by their distinct immunological and tissue specificities, either by letters (E- for epithelial, N- for neural, and P- for placental cadherins) or by numbers (cadherin-12 or N-cadherin 2 for brain-cadherin). Cadherins promote cell adhesion via a homophilic mechanism as in the construction of tissues and of the whole animal body.

Discrete abnormal tissue masses that protrude into the lumen of the INTESTINE. A polyp is attached to the intestinal wall either by a stalk, pedunculus, or by a broad base.

Diffusible gene products that act on homologous or heterologous molecules of viral or cellular DNA to regulate the expression of proteins.

A specific complex of WNT SIGNALING PATHWAY proteins that mediates the phosphorylation-dependent destruction of cytosolic BETA-CATENIN. The complex is disrupted by cell surface binding of WNT PROTEINS, which allows beta-catenin levels to rise to the point where they migrate to the CELL NUCLEUS and activate transcription.

A multi-functional catenin that is highly homologous to BETA CATENIN. Gamma catenin binds CADHERINS and helps link their cytoplasmic tails to ACTIN in the CYTOSKELETON via ALPHA CATENIN. It is also found in DESMOSOMES where it mediates the link between DESMOSOMAL CADHERINS and DESMOPLAKIN.

A hereditary disease caused by autosomal dominant mutations involving CHROMOSOME 19. It is characterized by the presence of INTESTINAL POLYPS, consistently in the JEJUNUM, and mucocutaneous pigmentation with MELANIN spots of the lips, buccal MUCOSA, and digits.

Wnt proteins are a large family of secreted glycoproteins that play essential roles in EMBRYONIC AND FETAL DEVELOPMENT, and tissue maintenance. They bind to FRIZZLED RECEPTORS and act as PARACRINE PROTEIN FACTORS to initiate a variety of SIGNAL TRANSDUCTION PATHWAYS. The canonical Wnt signaling pathway stabilizes the transcriptional coactivator BETA CATENIN.

A malignant kidney tumor, caused by the uncontrolled multiplication of renal stem (blastemal), stromal (STROMAL CELLS), and epithelial (EPITHELIAL CELLS) elements. However, not all three are present in every case. Several genes or chromosomal areas have been associated with Wilms tumor which is usually found in childhood as a firm lump in a child's side or ABDOMEN.

A polyposis syndrome due to an autosomal dominant mutation of the APC genes (GENES, APC) on CHROMOSOME 5. The syndrome is characterized by the development of hundreds of ADENOMATOUS POLYPS in the COLON and RECTUM of affected individuals by early adulthood.

Desmoplakins are cytoskeletal linker proteins that anchor INTERMEDIATE FILAMENTS to the PLASMA MEMBRANE at DESMOSOMES.

Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.

An interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein. Proteolytic processing of the precursor form by CASPASE 1 results in release of the active form of interleukin-1beta from the membrane.

The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.

Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)

Anchoring points where the CYTOSKELETON of neighboring cells are connected to each other. They are composed of specialized areas of the plasma membrane where bundles of the ACTIN CYTOSKELETON attach to the membrane through the transmembrane linkers, CADHERINS, which in turn attach through their extracellular domains to cadherins in the neighboring cell membranes. In sheets of cells, they form into adhesion belts (zonula adherens) that go all the way around a cell.

Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.

The part of a cell that contains the CYTOSOL and small structures excluding the CELL NUCLEUS; MITOCHONDRIA; and large VACUOLES. (Glick, Glossary of Biochemistry and Molecular Biology, 1990)

Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.

Surface ligands, usually glycoproteins, that mediate cell-to-cell adhesion. Their functions include the assembly and interconnection of various vertebrate systems, as well as maintenance of tissue integration, wound healing, morphogenic movements, cellular migrations, and metastasis.

An 11-kDa protein associated with the outer membrane of many cells including lymphocytes. It is the small subunit of the MHC class I molecule. Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. Beta 2-microglobulin is present in small amounts in serum, csf, and urine of normal people, and to a much greater degree in the urine and plasma of patients with tubular proteinemia, renal failure, or kidney transplants.

Histochemical localization of immunoreactive substances using labeled antibodies as reagents.

Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.

Adherence of cells to surfaces or to other cells.

A malignant epithelial tumor with a glandular organization.

One of two major pharmacologically defined classes of adrenergic receptors. The beta adrenergic receptors play an important role in regulating CARDIAC MUSCLE contraction, SMOOTH MUSCLE relaxation, and GLYCOGENOLYSIS.

An integrin beta subunit of approximately 85-kDa in size which has been found in INTEGRIN ALPHAIIB-containing and INTEGRIN ALPHAV-containing heterodimers. Integrin beta3 occurs as three alternatively spliced isoforms, designated beta3A-C.

A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.

A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.

A family of proteins that contain several 42-amino acid repeat domains and are homologous to the Drosophila armadillo protein. They bind to other proteins through their armadillo domains and play a variety of roles in the CELL including SIGNAL TRANSDUCTION, regulation of DESMOSOME assembly, and CELL ADHESION.

Established cell cultures that have the potential to propagate indefinitely.

A single-pass transmembrane glycoproteins that mediate CALCIUM-dependent CELL ADHESION and are core components of DESMOSOMES.

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

Direct contact of a cell with a neighboring cell. Most such junctions are too small to be resolved by light microscopy, but they can be visualized by conventional or freeze-fracture electron microscopy, both of which show that the interacting CELL MEMBRANE and often the underlying CYTOPLASM and the intervening EXTRACELLULAR SPACE are highly specialized in these regions. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p792)

An integrin found in FIBROBLASTS; PLATELETS; MONOCYTES, and LYMPHOCYTES. Integrin alpha5beta1 is the classical receptor for FIBRONECTIN, but it also functions as a receptor for LAMININ and several other EXTRACELLULAR MATRIX PROTEINS.

A glycogen synthase kinase that was originally described as a key enzyme involved in glycogen metabolism. It regulates a diverse array of functions such as CELL DIVISION, microtubule function and APOPTOSIS.

Also known as CD104 antigen, this protein is distinguished from other beta integrins by its relatively long cytoplasmic domain (approximately 1000 amino acids vs. approximately 50). Five alternatively spliced isoforms have been described.

This intrgrin is a key component of HEMIDESMOSOMES and is required for their formation and maintenance in epithelial cells. Integrin alpha6beta4 is also found on thymocytes, fibroblasts, and Schwann cells, where it functions as a laminin receptor (RECEPTORS, LAMININ) and is involved in wound healing, cell migration, and tumor invasiveness.

Integrin beta chains combine with integrin alpha chains to form heterodimeric cell surface receptors. Integrins have traditionally been classified into functional groups based on the identity of one of three beta chains present in the heterodimer. The beta chain is necessary and sufficient for integrin-dependent signaling. Its short cytoplasmic tail contains sequences critical for inside-out signaling.

A 44-kDa highly glycosylated plasma protein that binds phospholipids including CARDIOLIPIN; APOLIPOPROTEIN E RECEPTOR; membrane phospholipids, and other anionic phospholipid-containing moieties. It plays a role in coagulation and apoptotic processes. Formerly known as apolipoprotein H, it is an autoantigen in patients with ANTIPHOSPHOLIPID ANTIBODIES.

Integrin alpha4beta1 is a FIBRONECTIN and VCAM-1 receptor present on LYMPHOCYTES; MONOCYTES; EOSINOPHILS; NK CELLS and thymocytes. It is involved in both cell-cell and cell- EXTRACELLULAR MATRIX adhesion and plays a role in INFLAMMATION, hematopoietic cell homing and immune function, and has been implicated in skeletal MYOGENESIS; NEURAL CREST migration and proliferation, lymphocyte maturation and morphogenesis of the PLACENTA and HEART.

The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.

An integrin found on fibroblasts, platelets, endothelial and epithelial cells, and lymphocytes where it functions as a receptor for COLLAGEN and LAMININ. Although originally referred to as the collagen receptor, it is one of several receptors for collagen. Ligand binding to integrin alpha2beta1 triggers a cascade of intracellular signaling, including activation of p38 MAP kinase.

A subclass of beta-adrenergic receptors (RECEPTORS, ADRENERGIC, BETA). The adrenergic beta-2 receptors are more sensitive to EPINEPHRINE than to NOREPINEPHRINE and have a high affinity for the agonist TERBUTALINE. They are widespread, with clinically important roles in SKELETAL MUSCLE; LIVER; and vascular, bronchial, gastrointestinal, and genitourinary SMOOTH MUSCLE.

A RHO GTP-BINDING PROTEIN involved in regulating signal transduction pathways that control assembly of focal adhesions and actin stress fibers. This enzyme was formerly listed as EC 3.6.1.47.

The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.

RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.

A rac GTP-binding protein involved in regulating actin filaments at the plasma membrane. It controls the development of filopodia and lamellipodia in cells and thereby influences cellular motility and adhesion. It is also involved in activation of NADPH OXIDASE. This enzyme was formerly listed as EC 3.6.1.47.

Serologic tests in which a positive reaction manifested by visible CHEMICAL PRECIPITATION occurs when a soluble ANTIGEN reacts with its precipitins, i.e., ANTIBODIES that can form a precipitate.

Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

The process of moving proteins from one cellular compartment (including extracellular) to another by various sorting and transport mechanisms such as gated transport, protein translocation, and vesicular transport.

A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors(RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation.

A soluble factor produced by MONOCYTES; MACROPHAGES, and other cells which activates T-lymphocytes and potentiates their response to mitogens or antigens. Interleukin-1 is a general term refers to either of the two distinct proteins, INTERLEUKIN-1ALPHA and INTERLEUKIN-1BETA. The biological effects of IL-1 include the ability to replace macrophage requirements for T-cell activation.

Integrin beta-1 chains which are expressed as heterodimers that are noncovalently associated with specific alpha-chains of the CD49 family (CD49a-f). CD29 is expressed on resting and activated leukocytes and is a marker for all of the very late activation antigens on cells. (from: Barclay et al., The Leukocyte Antigen FactsBook, 1993, p164)

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

A cell surface receptor mediating cell adhesion to the EXTRACELLULAR MATRIX and to other cells via binding to LAMININ. It is involved in cell migration, embryonic development, leukocyte activation and tumor cell invasiveness. Integrin alpha6beta1 is the major laminin receptor on PLATELETS; LEUKOCYTES; and many EPITHELIAL CELLS, and ligand binding may activate a number of signal transduction pathways. Alternative splicing of the cytoplasmic domain of the alpha6 subunit (INTEGRIN ALPHA6) results in the formation of A and B isoforms of the heterodimer, which are expressed in a tissue-specific manner.

The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.

The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.

A subclass of beta-adrenergic receptors (RECEPTORS, ADRENERGIC, BETA). The adrenergic beta-1 receptors are equally sensitive to EPINEPHRINE and NOREPINEPHRINE and bind the agonist DOBUTAMINE and the antagonist METOPROLOL with high affinity. They are found in the HEART, juxtaglomerular cells, and in the central and peripheral nervous systems.

A group of desmosomal cadherins with cytoplasmic tails that resemble those of classical CADHERINS.

Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.

Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.

Integrin alpha1beta1 functions as a receptor for LAMININ and COLLAGEN. It is widely expressed during development, but in the adult is the predominant laminin receptor (RECEPTORS, LAMININ) in mature SMOOTH MUSCLE CELLS, where it is important for maintenance of the differentiated phenotype of these cells. Integrin alpha1beta1 is also found in LYMPHOCYTES and microvascular endothelial cells, and may play a role in angiogenesis. In SCHWANN CELLS and neural crest cells, it is involved in cell migration. Integrin alpha1beta1 is also known as VLA-1 and CD49a-CD29.

The barrier between capillary blood and alveolar air comprising the alveolar EPITHELIUM and capillary ENDOTHELIUM with their adherent BASEMENT MEMBRANE and EPITHELIAL CELL cytoplasm. PULMONARY GAS EXCHANGE occurs across this membrane.

The parts of a macromolecule that directly participate in its specific combination with another molecule.

A large family of MONOMERIC GTP-BINDING PROTEINS that are involved in regulation of actin organization, gene expression and cell cycle progression. This enzyme was formerly listed as EC 3.6.1.47.

A scaffolding protein that is a critical component of the axin signaling complex which binds to ADENOMATOUS POLYPOSIS COLI PROTEIN; GLYCOGEN SYNTHASE KINASE 3; and CASEIN KINASE I.

Proteins prepared by recombinant DNA technology.

Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.

A cell line derived from cultured tumor cells.

The network of filaments, tubules, and interconnecting filamentous bridges which give shape, structure, and organization to the cytoplasm.

Alzheimer's disease: clues from flies and worms. (1/5919)

Presenilin mutations give rise to familial Alzheimer's disease and result in elevated production of amyloid beta peptide. Recent evidence that presenilins act in developmental signalling pathways may be the key to understanding how senile plaques, neurofibrillary tangles and apoptosis are all biochemically linked. (+info)

The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin. (2/5919)

Ubiquitin-conjugation targets numerous cellular regulators for proteasome-mediated degradation. Thus, the identification of ubiquitin ligases and their physiological substrates is crucially important, especially for those cases in which aberrant levels of regulatory proteins (e.g., beta-catenin, p27) result from a deregulated ubiquitination pathway. In yeast, the proteolysis of several G1 regulators is controlled by ubiquitin ligases (or SCFs) formed by three subunits: Skp1, Cul A (Cdc53), and one of many F-box proteins. Specific F-box proteins (Fbps) recruit different substrates to the SCF. Although many Fbps have been identified in mammals, their specific substrates and the existence of multiple SCFs have not yet been reported. We have found that one human Fbp, beta-Trcp (beta-Transducin repeat containing protein), does indeed form a novel SCF with human Skp1 and Cul1. Consistent with recent reports indicating that Xenopus and Drosophila beta-Trcp homologs act as negative regulators of the Wnt/beta-catenin signaling pathway, we report here that human beta-Trcp interacts with beta-catenin in vivo. Furthermore, beta-catenin is specifically stabilized in vivo by the expression of a dominant negative beta-Trcp. These results indicate that the Cul1/Skp1/beta-Trcp complex forms a ubiquitin ligase that mediates the degradation of beta-catenin. (+info)

Axin prevents Wnt-3a-induced accumulation of beta-catenin. (3/5919)

When Axin, a negative regulator of the Wnt signaling pathway, was expressed in COS cells, it coeluted with glycogen synthase kinase-3beta (GSK-3beta), beta-catenin, and adenomatous polyposis coli protein (APC) in a high molecular weight fraction on gel filtration column chromatography. In this fraction, GSK-3beta, beta-catenin, and APC were co-precipitated with Axin. Although beta-catenin was detected in the high molecular weight fraction in L cells on gel filtration column chromatography, addition of conditioned medium expressing Wnt-3a to the cells increased beta-catenin in the low molecular weight fraction. However, Wnt-3a-dependent accumulation of beta-catenin was greatly inhibited in L cells stably expressing Axin. Axin also suppressed Wnt-3a-dependent activation of Tcf-4 which binds to beta-catenin and acts as a transcription factor. These results suggest that Axin forms a complex with GSK-3beta, beta-catenin, and APC, resulting in the stimulation of the degradation of beta-catenin and that Wnt-3a induces the dissociation of beta-catenin from the Axin complex and accumulates beta-catenin. (+info)

Glucocorticoid down-regulation of fascin protein expression is required for the steroid-induced formation of tight junctions and cell-cell interactions in rat mammary epithelial tumor cells. (4/5919)

Glucocorticoid hormones, which are physiological regulators of mammary epithelium development, induce the formation of tight junctions in rat Con8 mammary epithelial tumor cells. We have discovered that, as part of this process, the synthetic glucocorticoid dexamethasone strongly and reversibly down-regulated the expression of fascin, an actin-bundling protein that also interacts with the adherens junction component beta-catenin. Ectopic constitutive expression of full-length mouse fascin containing a Myc epitope tag (Myc-fascin) in Con8 cells inhibited the dexamethasone stimulation of transepithelial electrical resistance, disrupted the induced localization of the tight junction protein occludin and the adherens junction protein beta-catenin to the cell periphery, and prevented the rearrangement of the actin cytoskeleton. Ectopic expression of either the carboxyl-terminal 213 amino acids of fascin, which includes the actin and beta-catenin-binding sites, or the amino-terminal 313 amino acids of fascin failed to disrupt the glucocorticoid induction of tight junction formation. Mammary tumor cells expressing the full-length Myc-fascin remained generally glucocorticoid responsive and displayed no changes in the levels or protein-protein interactions of junctional proteins or the amount of cytoskeletal associated actin filaments. However, a cell aggregation assay demonstrated that the expression of Myc-fascin abrogated the dexamethasone induction of cell-cell adhesion. Our results implicate the down-regulation of fascin as a key intermediate step that directly links glucocorticoid receptor signaling to the coordinate control of junctional complex formation and cell-cell interactions in mammary tumor epithelial cells. (+info)

Frequent nuclear/cytoplasmic localization of beta-catenin without exon 3 mutations in malignant melanoma. (5/5919)

Beta-Catenin has a critical role in E-cadherin-mediated cell-cell adhesion, and it also functions as a downstream signaling molecule in the wnt pathway. Mutations in the putative glycogen synthase kinase 3beta phosphorylation sites near the beta-catenin amino terminus have been found in some cancers and cancer cell lines. The mutations render beta-catenin resistant to regulation by a complex containing the glycogen synthase kinase 3beta, adenomatous polyposis coli, and axin proteins. As a result, beta-catenin accumulates in the cytosol and nucleus and activates T-cell factor/ lymphoid enhancing factor transcription factors. Previously, 6 of 27 melanoma cell lines were found to have beta-catenin exon 3 mutations affecting the N-terminal phosphorylation sites (Rubinfeld B, Robbins P, Elgamil M, Albert I, Porfiri E, Polakis P: Stabilization of beta-catenin by genetic defects in melanoma cell lines. Science 1997, 275:1790-1792). To assess the role of beta-catenin defects in primary melanomas, we undertook immunohistochemical and DNA sequencing studies in 65 melanoma specimens. Nuclear and/or cytoplasmic localization of beta-catenin, a potential indicator of wnt pathway activation, was seen focally within roughly one third of the tumors, though a clonal somatic mutation in beta-catenin was found in only one case (codon 45 Ser-->Pro). Our findings demonstrate that beta-catenin mutations are rare in primary melanoma, in contrast to the situation in melanoma cell lines. Nonetheless, activation of beta-catenin, as indicated by its nuclear and/or cytoplasmic localization, appears to be frequent in melanoma, and in some cases, it may reflect focal and transient activation of the wnt pathway within the tumor. (+info)

Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway. (6/5919)

Overexpression of cell surface glycoproteins of the CD44 family is an early event in the colorectal adenoma-carcinoma sequence. This suggests a link with disruption of APC tumor suppressor protein-mediated regulation of beta-catenin/Tcf-4 signaling, which is crucial in initiating tumorigenesis. To explore this hypothesis, we analyzed CD44 expression in the intestinal mucosa of mice and humans with genetic defects in either APC or Tcf-4, leading to constitutive activation or blockade of the beta-catenin/Tcf-4 pathway, respectively. We show that CD44 expression in the non-neoplastic intestinal mucosa of Apc mutant mice is confined to the crypt epithelium but that CD44 is strongly overexpressed in adenomas as well as in invasive carcinomas. This overexpression includes the standard part of the CD44 (CD44s) as well as variant exons (CD44v). Interestingly, deregulated CD44 expression is already present in aberrant crypt foci with dysplasia (ACFs), the earliest detectable lesions of colorectal neoplasia. Like ACFs of Apc-mutant mice, ACFs of familial adenomatous polyposis (FAP) patients also overexpress CD44. In sharp contrast, Tcf-4 mutant mice show a complete absence of CD44 in the epithelium of the small intestine. This loss of CD44 concurs with loss of stem cell characteristics, shared with adenoma cells. Our results indicate that CD44 expression is part of a genetic program controlled by the beta-catenin/Tcf-4 signaling pathway and suggest a role for CD44 in the generation and turnover of epithelial cells. (+info)

Cadherin-11 is expressed in invasive breast cancer cell lines. (7/5919)

In several cancers, including breast cancer, loss of E-cadherin expression is correlated with a loss of the epithelial phenotype and with a gain of invasiveness. Cells that have lost E-cadherin expression are either poorly invasive with a rounded phenotype, or highly invasive, with a mesenchymal phenotype. Most cells lacking E-cadherin still retain weak calcium-dependent adhesion, indicating the presence of another cadherin family member. We have now examined the expression of the mesenchymal cadherin, cadherin-11, in breast cancer cell lines. Cadherin-11 mRNA and protein, as well as a variant form, are expressed in the most invasive cell lines but not in any of the noninvasive cell lines. Cadherin-11 is localized to a detergent-soluble pool and is associated with both alpha- and beta-catenin. Immunocytochemistry shows that cadherin-11 is localized to the cell membrane at sites of cell-cell contact as well as at lamellipodia-like projections, which do not interact with other cells. These results suggest that cadherin-11 expression may be well correlated with the invasive phenotype in cancer cells and may serve as a molecular marker for the more aggressive, invasive subset of tumors. Cadherin-11 may mediate the interaction between malignant tumor cells and other cell types that normally express cadherin-11, such as stromal cells or osteoblasts or perhaps even with the surrounding extracellular matrix, thus facilitating tumor cell invasion and metastasis. (+info)

Coupling assembly of the E-cadherin/beta-catenin complex to efficient endoplasmic reticulum exit and basal-lateral membrane targeting of E-cadherin in polarized MDCK cells. (8/5919)

The E-cadherin/catenin complex regulates Ca++-dependent cell-cell adhesion and is localized to the basal-lateral membrane of polarized epithelial cells. Little is known about mechanisms of complex assembly or intracellular trafficking, or how these processes might ultimately regulate adhesion functions of the complex at the cell surface. The cytoplasmic domain of E-cadherin contains two putative basal-lateral sorting motifs, which are homologous to sorting signals in the low density lipoprotein receptor, but an alanine scan across tyrosine residues in these motifs did not affect the fidelity of newly synthesized E-cadherin delivery to the basal-lateral membrane of MDCK cells. Nevertheless, sorting signals are located in the cytoplasmic domain since a chimeric protein (GP2CAD1), comprising the extracellular domain of GP2 (an apical membrane protein) and the transmembrane and cytoplasmic domains of E-cadherin, was efficiently and specifically delivered to the basal-lateral membrane. Systematic deletion and recombination of specific regions of the cytoplasmic domain of GP2CAD1 resulted in delivery of <10% of these newly synthesized proteins to both apical and basal-lateral membrane domains. Significantly, >90% of each mutant protein was retained in the ER. None of these mutants formed a strong interaction with beta-catenin, which normally occurs shortly after E-cadherin synthesis. In addition, a simple deletion mutation of E-cadherin that lacks beta-catenin binding is also localized intracellularly. Thus, beta-catenin binding to the whole cytoplasmic domain of E-cadherin correlates with efficient and targeted delivery of E-cadherin to the lateral plasma membrane. In this capacity, we suggest that beta-catenin acts as a chauffeur, to facilitate transport of E-cadherin out of the ER and the plasma membrane. (+info)

There are several types of intestinal polyps, including:

1. Adenomatous polyps: These are the most common type of polyp and have the potential to become malignant (cancerous) over time if left untreated.
2. Hyperplastic polyps: These polyps are benign and do not have the potential to become cancerous.
3. Inflammatory polyps: These polyps are caused by inflammation in the intestines and are typically seen in conditions such as ulcerative colitis or Crohn's disease.
4. Villous adenomas: These polyps are benign growths that occur on the villi (small projections) of the intestinal lining. They have the potential to become malignant over time if left untreated.

Intestinal polyps can cause a variety of symptoms, including abdominal pain, rectal bleeding, and changes in bowel movements. However, many people with intestinal polyps do not experience any symptoms at all. Intestinal polyps are typically detected during a colonoscopy or other imaging tests.

If you have been diagnosed with an intestinal polyp, your doctor may recommend one of the following treatments:

1. Watchful waiting: If your polyp is small and not causing any symptoms, your doctor may recommend monitoring it closely with regular colonoscopies to see if it grows or changes over time.
2. Removal: Polyps can be removed during a colonoscopy using a technique called endoscopic mucosal resection (EMR) or by surgery.
3. Chemoprevention: In some cases, your doctor may recommend medications such as aspirin or sulindac to help reduce the risk of polyps growing back.

It's important to note that while intestinal polyps are generally not cancerous, they can sometimes become malignant over time if left untreated. Therefore, it is important to follow your doctor's recommendations for monitoring and treatment closely.

The main features of PJS include:

* Multiple hamartomas in the gastrointestinal tract, which can lead to abdominal pain, nausea, vomiting, and rectal bleeding.
* Hamartomas in the lungs, which can cause coughing, wheezing, and shortness of breath.
* Hamartomas in the sex organs, which can lead to infertility, irregular menstrual cycles, and breast tumors.
* An increased risk of developing various types of cancer, including colon, lung, pancreatic, and breast cancer.
* A characteristic "speckled" appearance of the skin, caused by the accumulation of pigmented cells.

PJS is usually diagnosed in children or young adults, and it affects approximately 1 in 250,000 to 1 in 500,000 individuals worldwide. There is no cure for PJS, but regular monitoring and surveillance can help detect and treat hamartomas and cancerous lesions early on. Treatment options may include surgery, chemotherapy, and radiation therapy, depending on the location and severity of the tumors.

Wilms tumor accounts for about 5% of all childhood kidney cancers and usually affects only one kidney. The cancerous cells in the kidney are called blastema cells, which are immature cells that have not yet developed into normal kidney tissue.

The symptoms of Wilms tumor can vary depending on the size and location of the tumor, but they may include:

* Abdominal pain or swelling
* Blood in the urine
* Fever
* Vomiting
* Weight loss
* Loss of appetite

Wilms tumor is diagnosed through a combination of imaging tests such as ultrasound, CT scans, and MRI scans, and a biopsy to confirm the presence of cancer cells.

Treatment for Wilms tumor typically involves a combination of surgery, chemotherapy, and radiation therapy. The specific treatment plan will depend on the stage and location of the tumor, as well as the age and overall health of the child. In some cases, the affected kidney may need to be removed if the cancer is not completely removable by surgery or if it has spread to other parts of the body.

The prognosis for Wilms tumor has improved significantly over the past few decades due to advances in treatment and early detection. According to the American Cancer Society, the 5-year survival rate for children with Wilms tumor is about 90% if the cancer is diagnosed before it has spread to other parts of the body. However, the cancer can recur in some cases, especially if it has spread to other parts of the body at the time of initial diagnosis.

Overall, while Wilms tumor is a serious and potentially life-threatening condition, with prompt and appropriate treatment, many children with this disease can achieve long-term survival and a good quality of life.

The APC gene is a tumor suppressor gene that helps regulate cell growth and prevent the formation of tumors. Mutations in the APC gene can cause the development of adenomas, which are precancerous growths that can eventually become colon cancer if left untreated.

APC mutations can be inherited from one's parents or can occur spontaneously. The risk of developing colorectal cancer is increased in people with an APC mutation, and regular screening and monitoring is recommended to detect and remove any precancerous growths before they become cancerous.

Symptoms of APC may include abdominal pain, diarrhea, rectal bleeding, and weight loss. Treatment for APC typically involves removal of the affected portion of the colon and rectum, followed by ongoing monitoring and screening to detect any recurrences.

In summary, adenomatous polyposis coli (APC) is a genetic condition that increases the risk of developing colorectal cancer and other cancers. It is caused by mutations in the APC gene and can be inherited or acquired spontaneously. Symptoms may include abdominal pain, diarrhea, rectal bleeding, and weight loss, and treatment typically involves removal of the affected portion of the colon and rectum, followed by ongoing monitoring and screening.

The causes of colorectal neoplasms are not fully understood, but factors such as age, genetics, diet, and lifestyle have been implicated. Symptoms of colorectal cancer can include changes in bowel habits, blood in the stool, abdominal pain, and weight loss. Screening for colorectal cancer is recommended for adults over the age of 50, as it can help detect early-stage tumors and improve survival rates.

There are several subtypes of colorectal neoplasms, including adenomas (which are precancerous polyps), carcinomas (which are malignant tumors), and lymphomas (which are cancers of the immune system). Treatment options for colorectal cancer depend on the stage and location of the tumor, but may include surgery, chemotherapy, radiation therapy, or a combination of these.

Research into the causes and treatment of colorectal neoplasms is ongoing, and there has been significant progress in recent years. Advances in screening and treatment have improved survival rates for patients with colorectal cancer, and there is hope that continued research will lead to even more effective treatments in the future.

Adenocarcinoma is a term used to describe a variety of different types of cancer that arise in glandular tissue, including:

1. Colorectal adenocarcinoma (cancer of the colon or rectum)
2. Breast adenocarcinoma (cancer of the breast)
3. Prostate adenocarcinoma (cancer of the prostate gland)
4. Pancreatic adenocarcinoma (cancer of the pancreas)
5. Lung adenocarcinoma (cancer of the lung)
6. Thyroid adenocarcinoma (cancer of the thyroid gland)
7. Skin adenocarcinoma (cancer of the skin)

The symptoms of adenocarcinoma depend on the location of the cancer and can include:

1. Blood in the stool or urine
2. Abdominal pain or discomfort
3. Changes in bowel habits
4. Unusual vaginal bleeding (in the case of endometrial adenocarcinoma)
5. A lump or thickening in the breast or elsewhere
6. Weight loss
7. Fatigue
8. Coughing up blood (in the case of lung adenocarcinoma)

The diagnosis of adenocarcinoma is typically made through a combination of imaging tests, such as CT scans, MRI scans, and PET scans, and a biopsy, which involves removing a sample of tissue from the affected area and examining it under a microscope for cancer cells.

Treatment options for adenocarcinoma depend on the location of the cancer and can include:

1. Surgery to remove the tumor
2. Chemotherapy, which involves using drugs to kill cancer cells
3. Radiation therapy, which involves using high-energy X-rays or other particles to kill cancer cells
4. Targeted therapy, which involves using drugs that target specific molecules on cancer cells to kill them
5. Immunotherapy, which involves using drugs that stimulate the immune system to fight cancer cells.

The prognosis for adenocarcinoma is generally good if the cancer is detected and treated early, but it can be more challenging to treat if the cancer has spread to other parts of the body.

... , also known as beta-catenin (β-catenin), is a protein that in humans is encoded by the CTNNB1 gene. Beta-catenin ... Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin ... Beta-catenin is widely expressed in many tissues. In cardiac muscle, beta-catenin localizes to adherens junctions in ... On the other hand, BCL9 and BCL9L must compete with α-catenin to access β-catenin molecules. The cellular level of beta-catenin ...

https://en.wikipedia.org/wiki/Catenin_beta-1

... is a protein that in humans is encoded by the DACT2 gene. GRCh38: Ensembl ... "Entrez Gene: Dishevelled binding antagonist of beta catenin 2". Retrieved 2017-09-10. Koga Y, Yao T, Hirahashi M, Kumashiro Y, ... "Flat adenoma-carcinoma sequence with high-malignancy potential as demonstrated by CD10 and beta-catenin expression: a different ... "DACT2 is a functional tumor suppressor through inhibiting Wnt/β-catenin pathway and associated with poor survival in colon ...

https://en.wikipedia.org/wiki/Dishevelled_binding_antagonist_of_beta_catenin_2

... (Dact1, previously known as Dapper, Dpr1, Frodo) is a protein that in humans ... "DACT1 dishevelled binding antagonist of beta catenin 1 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved ... "Frodo links Dishevelled to the p120-catenin/Kaiso pathway: distinct catenin subfamilies promote Wnt signals". Developmental ... a Dishevelled-Associated Antagonist of β-Catenin and JNK Signaling, Is Required for Notochord Formation". Developmental Cell. 2 ...

https://en.wikipedia.org/wiki/Dishevelled_binding_antagonist_of_beta_catenin_1

Takemaru, Ken-Ichi (2006). "Catenin, beta". AfCS-Nature Molecule Pages. doi:10.1038/mp.a000506.01. Rousseau, Simon (2011). "P38 ...

https://en.wikipedia.org/wiki/Signaling_Gateway_(website)

CTNNB1 (beta-catenin; a transcription gene) mutations are found in 14-44% of endometrial cancers and may indicate a good ... Beta-catenin mutations are commonly found in endometrial cancers with squamous cells. FGFR2 mutations are found in ... The CTNNB1 (beta-catenin) gene is most commonly mutated in the squamous subtype of endometrioid adenocarcinoma. Serous ...

https://en.wikipedia.org/wiki/Endometrial_cancer

Wnt/beta-catenin Pathway. The role of Tbx2 in Wnt signaling has yet to be confirmed; however, up-regulation of Tbx2 in the beta ... catenin signaling pathway leads to loss of the adhesion molecule E-cadherin. This returns cells to a mesenchymal state, and ...

https://en.wikipedia.org/wiki/TBX2

"Wnt-4 activates the canonical beta-catenin-mediated Wnt pathway and binds Frizzled-6 CRD: functional implications of Wnt/beta- ... beta-catenin signaling cascade". The Journal of Biological Chemistry. 279 (15): 14879-88. doi:10.1074/jbc.M306421200. PMID ... catenin activity in kidney epithelial cells". Experimental Cell Research. 298 (2): 369-87. doi:10.1016/j.yexcr.2004.04.036. ...

https://en.wikipedia.org/wiki/Frizzled-6

Beta-catenin is phosphorylated and degraded. An important protein in the cell cycle, Cyclin D, is inhibited by inactivated GSK- ... and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells". Science. 270 (5243): 1811-1815. Bibcode:1995Sci ...

https://en.wikipedia.org/wiki/CCL5

"Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during development". Cell ... The Pitx2 gene plays a role in lung adenocarcinoma that is dependent on activating the Wnt/β-catenin signaling pathway. When ... cVg1 is a Transforming growth factor beta signal that is expressed posteriorly before the formation of the embryo germ layers. ... analyzing experimental findings from this Wnt/β-catenin signaling pathway, a TCGA dataset showed that Pitx2 had a positive ...

https://en.wikipedia.org/wiki/PITX2

Beta-catenin-like protein 1 is a protein that in humans is encoded by the CTNNBL1 gene. The protein encoded by this gene ... "Entrez Gene: CTNNBL1 catenin, beta like 1". Human CTNNBL1 genome location and CTNNBL1 gene details page in the UCSC Genome ... In addition, the encoded protein contains Armadillo/beta-catenin-like repeats, which have been implicated in protein-protein ...

https://en.wikipedia.org/wiki/CTNNBL1

Yang F, Li X, Sharma M, Sasaki CY, Longo DL, Lim B, Sun Z (March 2002). "Linking beta-catenin to androgen-signaling pathway". ... Masiello D, Chen SY, Xu Y, Verhoeven MC, Choi E, Hollenberg AN, Balk SP (October 2004). "Recruitment of beta-catenin by wild- ... Amir AL, Barua M, McKnight NC, Cheng S, Yuan X, Balk SP (August 2003). "A direct beta-catenin-independent interaction between ... Androgen receptor has been shown to interact with: AKT1, BAG1, Beta-catenin, BRCA1, C-jun, Calmodulin 1, Caveolin 1, CDK9, ...

https://en.wikipedia.org/wiki/Androgen_receptor

... and increased levels of active beta-catenin. Since each of these contribute to regulating cell proliferation, deletion of HDAC7 ... "Histone deacetylase 7 controls endothelial cell growth through modulation of beta-catenin". Circulation Research. 106 (7): 1202 ... One study showed that HDAC7 suppresses proliferation and β-catenin activity in chondrocytes. This was shown by knocking out ... Overall, this study demonstrated that HDAC7 once again interacts with β-catenin to keep endothelial cells in a low ...

https://en.wikipedia.org/wiki/HDAC7

Wong NA, Pignatelli M (Feb 2002). "Beta-catenin--a linchpin in colorectal carcinogenesis?". The American Journal of Pathology. ... GSK-3β, inhibited in some cancer, regulates the stability of β-catenin in cytoplasm and subsequently, cytosolic β-catenin moves ... Ectopic CD97 expression upregulates the expression of N-cadherin and β-catenin in HT1080 fibrosarcoma cells leading to enhanced ... Transgenic expression of a CD97 in mice enhanced levels of nonphosphorylated membrane-bound β-catenin and phosphorylated Akt. ...

https://en.wikipedia.org/wiki/CD97

"Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during development". Cell ...

https://en.wikipedia.org/wiki/PDLIM1

Wnt/beta-catenin pathway: modulating anticancer immune response. J Hematol Oncol 10, 101 (2017). https://doi.org/10.1186/s13045 ... TMED5 has been found to interact with WNT7B, activating the canonical WNT-CTNNB1/β-catenin signaling pathway. This pathway is ... The structure of TMED5 isoform 1 consists of beta strands making up the lumenal region, disparate coil-coiled regions, alpha ... to numerous cancers because upregulation of the Wnt/β-catenin signaling pathway leads to cytosolic accumulation of β-catenin, ...

https://en.wikipedia.org/wiki/TMED5

"Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation". Molecular Cell ... "Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex". Genes & ... "A noncanonical sequence phosphorylated by casein kinase 1 in beta-catenin may play a role in casein kinase 1 targeting of ... "Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway". Genes & Development. 16 ( ...

https://en.wikipedia.org/wiki/CSNK1D

Graham TA, Weaver C, Mao F, Kimelman D, Xu W (Dec 2000). "Crystal structure of a beta-catenin/Tcf complex". Cell. 103 (6): 885- ... Balaz P, Plaschke J, Krüger S, Görgens H, Schackert HK (Aug 2010). "TCF-3, 4 protein expression correlates with beta-catenin ... These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the ... "Lovastatin protects human neurons against Abeta-induced toxicity and causes activation of beta-catenin-TCF/LEF signaling". ...

https://en.wikipedia.org/wiki/TCF7L1

Ge X, Jin Q, Zhang F, Yan T, Zhai Q (Jan 2009). "PCAF acetylates {beta}-catenin and improves its stability". Mol. Biol. Cell. ... Asano Y, Czuwara J, Trojanowska M (November 2007). "Transforming growth factor-beta regulates DNA binding activity of ...

https://en.wikipedia.org/wiki/PCAF

... and stabilize beta-catenin. Mutant of presenilin-1 that reduces the ability to stabilize beta-catenin complex leads to ... presenilin-1 was also found to play a role in beta-catenin phosphorylation. Beta-catenin is coupled by presenilin-1 and ... "Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in ... Tesco G, Kim TW, Diehlmann A, Beyreuther K, Tanzi RE (December 1998). "Abrogation of the presenilin 1/beta-catenin interaction ...

https://en.wikipedia.org/wiki/Presenilin-1

Like beta-catenin and gamma-catenin, delta-catenins seem to interact with Presenilins. These catenin-presenilin interaction ... While beta-catenin acts as a transcription regulatory protein in the Wnt/TCF pathway, delta-catenin 1 has been implicated as a ... Delta-1-catenin and Delta-2-catenin are members of a subfamily of proteins with ten Armadillo-repeats. Delta-2-catenin is ... Teo JL, Ma H, Nguyen C, Lam C, Kahn M (August 2005). "Specific inhibition of CBP/beta-catenin interaction rescues defects in ...

https://en.wikipedia.org/wiki/Delta_catenin

December 2002). "Craniopharyngiomas of adamantinomatous type harbor beta-catenin gene mutations". The American Journal of ...

https://en.wikipedia.org/wiki/Craniopharyngioma

... has been shown to interact with Beta-catenin. GRCh38: Ensembl release 89: ENSG00000152104 - Ensembl, May 2017 GRCm38: ... "The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates beta-catenin". Molecular ... "The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates beta-catenin". Molecular ...

https://en.wikipedia.org/wiki/PTPN14

"Identification of the domain of alpha-catenin involved in its association with beta-catenin and plakoglobin (gamma-catenin)". ... "A mutation in alpha-catenin disrupts adhesion in clone A cells without perturbing its actin and beta-catenin binding activity ... "The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin". The ... "The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin". The ...

https://en.wikipedia.org/wiki/Plakoglobin

"Analysis of beta-catenin aggregation and localization using GFP fusion proteins: nuclear import of alpha-catenin by the beta- ... Tang W, Dodge M, Gundapaneni D, Michnoff C, Roth M, Lum L (July 2008). "A genome-wide RNAi screen for Wnt/beta-catenin pathway ... PDB: 2GL7; Sampietro J, Dahlberg CL, Cho US, Hinds TR, Kimelman D, Xu W (October 2006). "Crystal structure of a beta-catenin/ ... Sun P, Xiong H, Kim TH, Ren B, Zhang Z (February 2006). "Positive inter-regulation between beta-catenin/T cell factor-4 ...

https://en.wikipedia.org/wiki/TCF7L2

Sampietro J, Dahlberg CL, Cho US, Hinds TR, Kimelman D, Xu W (2006). "Crystal structure of a beta-catenin/BCL9/Tcf4 complex". ... "The Tumor-Suppressor WWOX and HDAC3 Inhibit the Transcriptional Activity of the β-Catenin Coactivator BCL9-2 in Breast Cancer ... "Identification of a link between Wnt/β-catenin signalling and the cell fusion pathway". Nat Commun. 2: 548. doi:10.1038/ ...

https://en.wikipedia.org/wiki/BCL9L

Another study shows FAM158A responds to Beta-catenin depletion. Although there are no known beta-catenin binding sites in the ... there is a NeuroD site and NeuroD responds to beta-catenin. The paralog to FAM158A is commonly known as Cox4NB and is located ... "Aurora kinase A is a target of Wnt/beta-catenin involved in multiple myeloma disease progression". Blood. 114 (13): 2699-708. ...

https://en.wikipedia.org/wiki/Fam158a

Lamberti C, Lin KM, Yamamoto Y, Verma U, Verma IM, Byers S, Gaynor RB (November 2001). "Regulation of beta-catenin function by ... Woronicz JD, Gao X, Cao Z, Rothe M, Goeddel DV (October 1997). "IkappaB kinase-beta: NF-kappaB activation and complex formation ... Sakurai H, Miyoshi H, Toriumi W, Sugita T (April 1999). "Functional interactions of transforming growth factor beta-activated ... lymphotoxin beta receptor, and CD40". J. Biol. Chem. 276 (18): 14602-6. doi:10.1074/jbc.C100103200. PMID 11278268. Ninomiya- ...

https://en.wikipedia.org/wiki/CHUK

Lamberti C, Lin KM, Yamamoto Y, Verma U, Verma IM, Byers S, Gaynor RB (November 2001). "Regulation of beta-catenin function by ... IKK-β also known as inhibitor of nuclear factor kappa-B kinase subunit beta is a protein that in humans is encoded by the IKBKB ... Devin A, Lin Y, Yamaoka S, Li Z, Karin M (June 2001). "The alpha and beta subunits of IkappaB kinase (IKK) mediate TRAF2- ... Woronicz JD, Gao X, Cao Z, Rothe M, Goeddel DV (October 1997). "IkappaB kinase-beta: NF-kappaB activation and complex formation ...

https://en.wikipedia.org/wiki/IKK2

The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta- ... catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript ... CBY1 has been shown to interact with Beta-catenin. CBY1 has also been shown to interact with CEP164, FAM92A1, and RAB8. GRCh38 ... Takemaru K, Yamaguchi S, Lee YS, Zhang Y, Carthew RW, Moon RT (2003). "Chibby, a nuclear beta-catenin-associated antagonist of ...

https://en.wikipedia.org/wiki/Protein_chibby_homolog_1

This inhibits the expression of cadherins and beta-catenin. Cadherins are cell adhesion molecules, and beta-catenin helps to ...

https://en.wikipedia.org/wiki/Implantation_(embryology)

2004). "Identification of the leukocyte cell-derived chemotaxin 2 as a direct target gene of beta-catenin in the liver". ...

https://en.wikipedia.org/wiki/LECT2

WNT9A and WNT9B signal through the beta-catenin/Tcf pathway but do not play related roles as WNT3A and WNT3 in the same ... Wnt-3a promotes the beta-catenin/Tcf pathway which is tumor inducing and can cause cancer when expressed in particular cell ... WNT3A and WNT3 signal similarly through primarily the beta-catenin/Tcf pathway. WNT3A is located in the genome beside the WNT9A ... Filali M, Cheng N, Abbott D, Leontiev V, Engelhardt JF (September 2002). "Wnt-3A/beta-catenin signaling induces transcription ...

https://en.wikipedia.org/wiki/WNT3A

... nuclear translocation of androgen receptor complex with beta-catenin and T-cell factor 4 may bypass canonical Wnt signaling to ... Also, androgens, but not estrogens, increase beta adrenergic receptors while decreasing alpha adrenergic receptors- which ... norepinephrine then acting on lipolysis-inducing beta receptors. Males typically have more skeletal muscle mass than females. ...

https://en.wikipedia.org/wiki/Androgen

Evidence for its diverse roles in desmosomes and beta -catenin signaling". J. Biol. Chem. 277 (12): 10512-22. doi:10.1074/jbc. ...

https://en.wikipedia.org/wiki/Plakophilin-1

... cytochrome c release NF-κB WNT/beta-catenin mTOR ERK MAPK Bcl-2 The protein Src tyrosine kinase is overexpressed in Waldenström ... Beta-2 microglobulin and C-reactive protein test results are not specific for Waldenström macroglobulinemia. Beta-2 ... An M component with beta-to-gamma mobility is highly suggestive of Waldenström macroglobulinemia. Immunoelectrophoresis and ...

https://en.wikipedia.org/wiki/Waldenström_macroglobulinemia

... the Wnt signaling pathway by abrogating the interaction between the Wnt-dependent transcriptional co-factors beta-catenin and ... "LATS2 suppresses oncogenic Wnt signaling by disrupting β-catenin/BCL9 interaction". Cell Reports. 5 (6): 1650-1663. doi:10.1016 ...

https://en.wikipedia.org/wiki/Nocodazole

Schaefer KN, Peifer M (February 2019). "Wnt/Beta-Catenin Signaling Regulation and a Role for Biomolecular Condensates". ... including cross-beta polymerisation), and/or protein domains that induce head-to-tail oligomeric or polymeric clustering, might ...

https://en.wikipedia.org/wiki/Biomolecular_condensate

... binds with P53 to inhibit cell death and interacts with beta-catenin to promote the tissue-invasiveness of cancer cells; and 6 ...

https://en.wikipedia.org/wiki/Primary_effusion_lymphoma

... and hCGbeta transgenic female mice present with mammary Gland tumors exhibiting characteristics of the Wnt/beta-catenin pathway ... This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 5 subunit of chorionic gonadotropin ( ... The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and ... Chorionic gonadotropin, beta polypeptide 5 is a protein that in humans is encoded by the CGB5 gene. ...

https://en.wikipedia.org/wiki/CGB5

... cadherin-catenin complex with actin, vinculin with F-actin, microtubule with kinetochore particle, integrin alpha L beta 2 and ... integrin alpha M beta 2 with ICAM-1, integrin alpha V beta 3 with fibronectin, and integrin alpha IIb beta 3 with fibronectin ... CMR has been observed for interactions between integrin alpha 5 beta 1 and fibronectin and between G-actin and G-actin or F- ... The minimal cadherin-catenin complex binds to actin filaments under force". Science. 346 (6209): 1254211. doi:10.1126/science. ...

https://en.wikipedia.org/wiki/Catch_bond

... but the homologous human genes are independent from beta-catenin activation". The Biochemical Journal. 367 (Pt 3): 723-728. doi ...

https://en.wikipedia.org/wiki/Nuclear_receptor_4A1

"Engrailed-1 negatively regulates beta-catenin transcriptional activity by destabilizing beta-catenin via a glycogen synthase ... August 2006). "Beta-catenin activation is necessary and sufficient to specify the dorsal dermal fate in the mouse". ...

https://en.wikipedia.org/wiki/EN1_(gene)

In osteoarthritic chondrocytes the Wnt/beta-catenin pathway is activated with a significant up-regulation of beta-catenin mRNA ... He X, Semenov M, Tamai K, Zeng X (Apr 2004). "LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point ... Katoh M, Katoh M (Sep 2006). "Cross-talk of WNT and FGF signaling pathways at GSK3beta to regulate beta-catenin and SNAIL ... The catabolic role of LRP5 appears to be mediated by the Wnt/beta-catenin pathway in human osteoarthritis. The polyphenol ...

https://en.wikipedia.org/wiki/LRP5

January 2006). "R-Spondin proteins: a novel link to beta-catenin activation". Cell Cycle. 5 (1): 23-6. doi:10.4161/cc.5.1.2305 ... R-spondin 2 synergizes with canonical WNT to activate beta-catenin. RSPO2 has been proposed to regulate craniofacial patterning ... "R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis". Developmental Cell. 7 ...

https://en.wikipedia.org/wiki/R-spondin_2

However, in cases where APC gene is not mutated, mutations are found in the N-terminus of beta-catenin which renders it ... Sparks AB, Morin PJ, Vogelstein B, Kinzler KW (March 1998). "Mutational analysis of the APC/beta-catenin/Tcf pathway in ... APC gene product targets beta-catenin for degradation via ubiquitination at the N-terminus, thus regulating its cellular level ... This compact globular beta-grasp fold is found in ubiquitin, UBLs, and proteins that comprise a ubiquitin-like domain, e.g. the ...

https://en.wikipedia.org/wiki/Ubiquitin

"The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activation". The EMBO Journal. 20 (17 ...

https://en.wikipedia.org/wiki/SMARCD3

TGF-beta induces NEDD9 transcription. Based on inspection of sequence, the NEDD9 promoter also has potential binding sites for ... Consistent with these findings is a study demonstrating downregulation of epithelial markers (E-cadherin, occludin, β-catenin) ... TGF-beta is a regulator of tissue remodeling and epithelial-mesenchymal transition (EMT) in development, and promotes ... A number of studies have identified NEDD9 as a downstream effector in the TGF-beta signaling pathway, essential for promoting ...

https://en.wikipedia.org/wiki/NEDD9

Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin ... CTNND1 has been shown to interact with: Beta-catenin, CDH1, CDH2, Collagen, type XVII, alpha 1, Cortactin, FYN, MUC1, Nephrin, ... p120, and called catenin delta-1 is a protein that in humans is encoded by the CTNND1 gene. This gene encodes a member of the ... PSEN1, PTPN6, PTPRJ, PTPRM, VE-cadherin, YES1, and ZBTB33 Delta catenin Catenin CTNND2 GRCh38: Ensembl release 89: ...

https://en.wikipedia.org/wiki/P120_(protein)

... transcriptional activity of wild type and mutated oncogenic beta-catenin and affects membrane distribution of beta-catenin/E- ... Beta-catenin, E-cadherin (CDH-1), Epidermal growth factor receptor (EGFR), HER2, Plakoglobin, and α-catenin. ENSG00000273993 ... where it colocalizes and co-immunoprecipitates with β-catenin and plakoglobin/γ-catenin β-catenin may be a PTPkappa substrate. ... Wang SE, Wu FY, Shin I, Qu S, Arteaga CL (2005). "Transforming growth factor {beta} (TGF-{beta})-Smad target gene protein ...

https://en.wikipedia.org/wiki/PTPRK

... in human hepatocellular carcinomas with beta-catenin mutations". Hepatology. 37 (3): 528-33. doi:10.1053/jhep.2003.50029. PMID ... 2012). "R-Spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5". PLOS ONE. 7 (7): e40976. Bibcode ... "LGR5 interacts and cointernalizes with Wnt receptors to modulate Wnt/β-catenin signaling". Mol. Cell. Biol. 32 (11): 2054-64. ... "Oncogenic STRAP Supports Hepatocellular Carcinoma Growth by Enhancing Wnt/β-Catenin Signaling". Mol Cancer Res. 17 (2): 521-531 ...

https://en.wikipedia.org/wiki/LGR5

A recent study revealed that beta-catenin signaling, Wnt β-catenin, regulates the differentiation of TAC. NSCs in the SVZ have ...

https://en.wikipedia.org/wiki/Endogenous_regeneration

... beta-Catenin, delta-Catenins and NCadherin (via the Catenins). The nature and function of these interactions, detailed in ... 2007). "Densin and beta-catenin form a complex and co-localize in cultured podocyte cell junctions". Mol. Cell. Biochem. 305 (1 ... Izawa I, Nishizawa M, Ohtakara K, Inagaki M (2002). "Densin-180 interacts with delta-catenin/neural plakophilin-related ... Izawa, Ichiro; Nishizawa Miwako; Ohtakara Kazuhiro; Inagaki Masaki (Feb 2002). "Densin-180 interacts with delta-catenin/neural ...

https://en.wikipedia.org/wiki/LRRC7

"The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activation". The EMBO Journal. 20 (17 ...

https://en.wikipedia.org/wiki/SMARCA4

"The Wnt receptor FZD1 mediates chemoresistance in neuroblastoma through activation of the Wnt/beta-catenin pathway". Oncogene. ... "Expression of Wnt4 in human pituitary adenomas regulates activation of the beta-catenin-independent pathway". Endocrine ... One important example is the stabilization of β catenin, which increases the expression of target genes. For instance, TAFIIs ... In XX humans, WNT4 now cannot stabilize β-catenin. Furthermore, steroidogenic enzymes like CYP17A1 and HSD3B2 are not ...

https://en.wikipedia.org/wiki/WNT4

Knockdown of LIMP-2 with RNA interference decreased the binding of N-cadherin to the phosphorylated form of beta-catenin, and ...

https://en.wikipedia.org/wiki/SCARB2

... profile of microRNAs regulating adipogenesis by modulating the canonical Wnt/beta-catenin signaling pathway". BMC Genomics. 11 ...

https://en.wikipedia.org/wiki/Mir-344_microRNA_precursor_family

May 2007). "R-Etodolac decreases beta-catenin levels along with survival and proliferation of hepatoma cells". Journal of ... but inhibits beta-catenin levels in hepatoma cells. In the UK, Etodolac is licensed for the treatment of inflammation and pain ...

https://en.wikipedia.org/wiki/Etodolac

... ... Abstract Developmentally Programmed Tankyrase Activity Upregulates Beta-catenin and Licenses Progression of Embryonic Genome ... Synopsis Developmentally Programmed Tankyrase Activity Upregulates Beta-catenin and Licenses Progression of Embryonic Genome ... Story Developmentally Programmed Tankyrase Activity Upregulates Beta-catenin and Licenses Progression of Embryonic Genome ...

https://www.niehs.nih.gov/research/resources/articles_journals/recent/pdf_2020/developmentally_programmed_tankyrase_activity_upregulates_betacatenin_and_licenses_progression_of_embryonic_genome_activation.cfm

Michael Davidsons lab contains the insert Beta-Catenin. This plasmid is available through Addgene. ... mCerulean-Beta-Catenin-20 was a gift from Michael Davidson (Addgene plasmid # 55352 ; http://n2t.net/addgene:55352 ; RRID: ...

https://www.addgene.org/55352/

Proteintech Anti-beta-Catenin Polyclonal, Catalog # 51067-2-AP. Tested in Western Blot (WB), Immunocytochemistry (ICC/IF), ...

https://www.thermofisher.com/antibody/product/beta-Catenin-Antibody-Polyclonal/51067-2-AP

... catenin beta 1 (human). Find diseases associated with this biological target and compounds tested against it in bioassay ... ARM; Armadillo/beta-catenin-like repeats. cd00020. Location:399 → 518. ARM; Armadillo/beta-catenin-like repeats. An ... HIV-1 Vpu reduces the beta-catenin interaction with E-cadherin and the Vpu-mediated dissociation of beta-catenin with E- ... CTNNB1 catenin beta 1 [Homo sapiens] CTNNB1 catenin beta 1 [Homo sapiens]. Gene ID:1499 ...

https://www.ncbi.nlm.nih.gov/gene?term=(CTNNB1%5BGene%20Name%5D)%20AND%209606%5BTaxonomy%20ID%5D

Convergence of Wnt, beta-catenin, and cadherin pathways W James Nelson et al. Science. 2004. . ... Convergence of Wnt, beta-catenin, and cadherin pathways W James Nelson 1 , Roel Nusse ... Regulation of beta-catenin signaling in the Wnt pathway. Kikuchi A. Kikuchi A. Biochem Biophys Res Commun. 2000 Feb 16;268(2): ... Role for ICAT in beta-catenin-dependent nuclear signaling and cadherin functions. Gottardi CJ, Gumbiner BM. Gottardi CJ, et al. ...

https://pubmed.ncbi.nlm.nih.gov/15001769

TOPFLASH reporter assay to show that PEG markedly inhibited beta-catenin transcriptional activity. PEG did not alter total beta ... In this study, we assessed the ability of PEG to target cyclin D1-beta-catenin-mediated hyperproliferation in the azoxymethane- ... Because beta-catenin is the major regulator of cyclin D1 in colorectal cancer, we used the T-cell factor (Tcf)- ... catenin expression but rather its nuclear localization, leading us to assess E-cadherin expression (a major determinant of beta ...

https://edrn.nci.nih.gov/data-and-resources/publications/16928827-742-chemoprevention-of-colon-carcinogenesis-by-polyethylene-glycol-suppression-of-epithelial-proliferation-via-modulation-of-snailbeta-catenin-signaling/

Combination Cancer Immunotherapy with Dendritic Cell Vaccine and Nanoparticles Loaded with Interleukin-15 and Anti-beta-catenin ...

https://pesquisa.bvsalud.org/controlecancer/resource/pt/mdl-36477758

Beta-catenin, estradiol and lithium. Estrogens are important for sex-related differentiation of the brain and it is likely that ... Billin, A.N., Thirlwell, H. and Ayer, D.E (2000). Beta-catenin-histone deacetylase interactions regulate the transition of LEF1 ... Protein kinase c beta and the temporal lobe. Downregulation of the gene for protein kinase C beta (PRKCB1) in the temporal lobe ... One of the targets of cytosolic ERα is GSK3B, which is known to complex with β-catenin in the degradation of β-catenin. ERα ...

https://www.intechopen.com/chapters/45827

To define which cells respond to activated beta-catenin during mammalian development, we generated the beta-catenin-activated ... revealing an unsuspected dynamic pattern of beta-catenin transcriptional activity. Expression of the transgene was analyzed in ... In summary, BAT-gal mice unveil the entire complexity of Wntbeta-catenin signaling in mammals and have broad application ... indicating that BAT-gal mice are bona fide in vivo indicators of Wntbeta-catenin signaling. Analyses of BAT-gal expression in ...

https://www.neuroscience.ox.ac.uk/publications/458582?ad9644b8-0024-11ee-a69a-061ab7f93640

... Author. ... beta-Catenin signaling contributes to stemness and regulates early differentiation in murine embryonic stem cells. dc.title. ...

https://oparu.uni-ulm.de/xmlui/handle/123456789/47292?show=full

... , Miller JR, Hocking AM, Brown JD, ... Mechanism and function of signal transduction by the Wnt/beta-catenin and Wnt/Ca2+ pathways. Author(s): Miller JR, Hocking AM, ... Beta-catenin-independent Wnt pathways: signals, core proteins, and effectors. Author(s): James RG, Conrad WH, Moon RT ... Wnt/beta-catenin signaling: components, mechanisms, and diseases. Author(s): MacDonald BT, Tamai K, He X ...

https://www.indexindex.com/journal-of-diabetes-metabolism/mechanism-and-function-of-signal-transduction-by-the-wntbetacatenin-and-wntca2-pathways-676723.html

Antibody Details for beta-Catenin. WBI Title. Validation Status. Band Result. Date. Dilution. ...

https://discover.nci.nih.gov/abminer/antibodyDetail.do?antibodyId=551

Importantly, we showed that EGFR-phosphorylated PFKP Y64 has a critical role in AKT activation and AKT-mediated β-catenin S552 ... Importantly, we showed that EGFR-phosphorylated PFKP Y64 has a critical role in AKT activation and AKT-mediated β-catenin S552 ... These findings highlight a novel mechanism underlying a glycolytic enzyme-mediated β-catenin activation and underscore the ... These findings highlight a novel mechanism underlying a glycolytic enzyme-mediated β-catenin transactivation and underscore the ...

https://www.frontiersin.org/articles/10.3389/fonc.2020.00211/full

The CTNNB1 gene contains instructions for creating a protein called beta-catenin (β-catenin). Beta-catenin is found in cells ... These neurons can be used to better understand the effects of variants of the CTNNB1 gene on the function of the beta-catenin ... The programs goal is to introduce a corrected CTNNB1 gene into human cells that can produce a correct beta-catenin protein and ... Individuals with CTNNB1 syndrome have a variant of the CTNNB1 gene which prevents the normal beta-catenin protein from being ...

https://rarediseases.org/rare-diseases/ctnnb1-syndrome/

CTNNB1: catenin beta 1. *CTNND1: catenin delta 1. *CTNND2: catenin delta 2 ...

https://medlineplus.gov/genetics/gene-c/

We found that N6L and nucleolin interact with β-catenin. We found that the Wnt/β-catenin pathway is activated in PDAC and is ... In conclusion, in this study, we identified β-catenin as a new nucleolin interactor and suggest that the Wnt/β-catenin pathway ... N6L also inhibited the growth and the activation of the Wnt/β-catenin pathway in vivo in mice and in 3D cultures derived from ... N6L and nucleolin loss of function induced by siRNA inhibited Wnt pathway activation by preventing β-catenin stabilization in ...

https://www.mdpi.com/2072-6694/13/12/2986

... tumorsphere-forming efficiency induced by LGR5 could be regulated through the inhibition or activation of the Wnt/β-catenin ... Our previous study showed that LGR5 functions as a tumor promoter in cervical cancer by activating the Wnt/β-catenin pathway. ... Valkenburg KC, Graveel CR, Zylstra-Diegel CR, Zhong Z, Williams BO . Wnt/beta-catenin signaling in normal and cancer stem cells ... β-catenin signaling, DKK-1, an inhibitor of the Wnt/β-catenin pathway by binding to LRP6,22 was used to block the Wnt/β-catenin ...

https://www.nature.com/articles/cddis2017393?error=cookies_not_supported&code=690749c9-8c76-4f13-b6b9-c388c17deced

Induction of a beta-catenin-LEF-1 complex by wnt-1 and transforming mutants of beta-catenin.. Porfiri E; Rubinfeld B; Albert I ... WNT-1 and HGF regulate GSK3 beta activity and beta-catenin signaling in mammary epithelial cells.. Papkoff J; Aikawa M. Biochem ... beta-catenin].. Ogawa K; Yaginuma Y. Nihon Rinsho; 2001 Oct; 59 Suppl 6():161-6. PubMed ID: 11761935. [No Abstract] [Full Text ... 2. Lef/Tcf-dependent Wnt/beta-catenin signaling during Xenopus axis specification.. Geng X; Xiao L; Lin GF; Hu R; Wang JH; Rupp ...

https://pubmedhh.nlm.nih.gov/biomarkers/search.php?id=12019770&mod=related&page=1&outid=&proj=

Modelling spatially regulated beta-catenin dynamics and invasion in intestinal crypts. Biophysical journal. 99(3), 716-25 ... A multiple timescale analysis of a mathematical model of the Wnt/beta-catenin signalling pathway. J. Math. Biol.. 60, 131-160 ...

https://www.nottingham.ac.uk/mathematics/people/gary.mirams

This gene affects cellular signaling pathways by means of the beta-catenin pathway. [99] ...

https://www.medscape.com/article/989841-overview

Chan EF, Gat U, McNiff JM, Fuchs E. A common human skin tumour is caused by activating mutations in beta-catenin. Nat Genet. ... Kajino Y, Yamaguchi A, Hashimoto N, Matsuura A, Sato N, Kikuchi K. beta-Catenin gene mutation in human hair follicle-related ... Pilomatrix carcinomas contain mutations in CTNNB1, the gene encoding beta-catenin. J Cutan Pathol. 2005 Feb. 32(2):148-57. [ ... these data directly implicate beta-catenin/LEF misregulation as the major cause of hair matrix cell tumorigenesis in humans. [ ...

https://emedicine.medscape.com/article/1058965-overview

ESE1 binds to beta catenin and modulates its expression. 105th AACR annual meeting. Poster presentation. San Diego, CA, 2014, ... Identification of ESE1 as a β-Catenin Binding Protein. Anticancer Res. 2016 Jun;36(6):2697-703. PMID: 27272778 ...

https://www.nichd.nih.gov/research/atNICHD/Investigators/loh/personnel/yang

Molecular studies showed that the spectrum of beta-catenin mutations was markedly different in chlorophyllin-promoted colon ... and beta-catenin/Tcf signaling.. Authors: Blum, Carmen A; Xu, Meirong; Orner, Gayle A; Darío Díaz, G; Li, Qingjie; Dashwood, ... induce colon tumors in the rat that contain mutations in beta-catenin, but the mutation pattern can be influenced by exposure ... Substitution of critical Ser/Thr residues caused beta-catenin and c-Jun proteins to be markedly over-expressed compared with ...

https://tools.niehs.nih.gov/portfolio/index.cfm?do=portfolio.publicationDetail&id=243458

... will involve mapping beta-catenin activity in the developing PTEN haploinsufficient mouse brain and modulating beta-catenin ... Page and his colleagues predict that PTEN and Wnt-beta-catenin signaling act in a common pathway to control brain growth ... and Wnt-beta-catenin (e.g., CTNNB1, CHD8 and TCF4) signaling pathways. ... haploinsufficiency alters brain growth trajectory and scaling of neuronal and glial populations through elevated beta-catenin ...

https://www.sfari.org/funded-project/impact-of-pten-mutations-brain-growth-trajectory-and-scaling-of-cell-types/

Xu L, Corcoran RB, Welsh JW, Pennica D, Levine AJ: WISP-1 is a Wnt-1- and beta-catenin-responsive oncogene. Genes Dev 14: 585- ... Xu G, Arregui C, Lilien J, Balsamo J: PTP1B modulates the association of beta-catenin with N-cadherin through binding to an ... Dai C, Stolz DB, Kiss LP, Monga SP, Holzman LB, Liu Y: Wnt/beta-catenin signaling promotes podocyte dysfunction and albuminuria ... Easwaran V, Lee SH, Inge L, Guo L, Goldbeck C, Garrett E, et al.: beta-Catenin regulates vascular endothelial growth factor ...

https://journals.lww.com/jasn/pages/articleviewer.aspx?year=2021&issue=06000&article=00014&type=Fulltext

FoxM1 promotes beta-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesis. Cancer Cell. ... Deheuninck J, Luo K. Ski and SnoN, potent negative regulators of TGF-beta signaling. Cell Res. 2009;19(1):47-57.. View this ...

https://www.jci.org/articles/view/71104?utm_campaign=impact_2014_february&utm_content=short_url&utm_medium=pdf&utm_source=impact

... catenin and inactivation of the (APC) adenomatosis polyposis coli protein. In myeloid leukemia, non-phosphorylated beta_catenin ... A similar accumulation of unphosphorylated beta- catenin has also been observed in multiple myeloma cells. In colon cancer, the ... In general, these mutations involve Wnt signal transduction proteins including the activation of beta- ...

https://grants.nih.gov/grants/guide/pa-files/PA-06-282.html

Impact of Human Papillomavirus on Wnt/Beta-Catenin Signaling in Morphological Inconspicuous Cervicovaginal Cells Acta ...

https://karger.com/acy/article-abstract/46/2/271/7688/Cervicovaginal-Smear-Abnormalities-in-Sexually?redirectedFrom=fulltext

Because beta-catenin is the major regulator of cyclin D1 in colorectal cancer, we used the T-cell factor (Tcf)-TOPFLASH reporter assay to show that PEG markedly inhibited beta-catenin transcriptional activity. (nih.gov)
Moreover, BAT-gal expression identifies novel sites of Wnt signaling, like notochord, endothelia, and areas of the adult brain, revealing an unsuspected dynamic pattern of beta-catenin transcriptional activity. (ox.ac.uk)
Analyses of BAT-gal expression in the adenomatous polyposis coli (multiple intestinal neoplasia+) background revealed betacatenin transcriptional activity in intestinal adenomas but surprisingly not in normal crypt cells. (ox.ac.uk)
Increased transcriptional activity of β-catenin, which is essential for cell proliferation, migration, invasion, and survival ( 1 , 2 ), has been detected in many types of human cancer ( 3 - 6 ). (frontiersin.org)
15. Negative regulation of the Wnt-beta-catenin pathway by the transcriptional repressor HBP1. (nih.gov)

14. Induction of a beta-catenin-LEF-1 complex by wnt-1 and transforming mutants of beta-catenin. (nih.gov)
2004. Phosphorylation and ubiquitination of oncogenic mutants of beta-catenin containing substitutions at Asp32. . (oregonstate.edu)

Extracellular Vesicles Released from Cancer Cells Promote Tumorigenesis by Inducing Epithelial to Mesenchymal Transition via β-Catenin Signaling. (nih.gov)
Chemoprevention of colon carcinogenesis by polyethylene glycol: suppression of epithelial proliferation via modulation of SNAIL/beta-catenin signaling. (nih.gov)
13. WNT-1 and HGF regulate GSK3 beta activity and beta-catenin signaling in mammary epithelial cells. (nih.gov)
Activation of the Wnt/β-catenin pathway has effects on prostate cell proliferation, differentiation and the epithelial-mesenchymal transition, which is thought to regulate the invasive behaviour of tumour cells. (cicbiogune.es)
36. Järvinen E, Salazar-Ciudad I, Birchmeier W, Taketo MM, Jernvall J, Thesleff I. Continuous tooth generation in mouse is induced by activated epithelial Wnt/beta-catenin signaling. (bvsalud.org)

Characterization of the Subcellular Distribution of Phospho-β-catenin in Colorectal Cancer. (nih.gov)
In this study, we assessed the ability of PEG to target cyclin D1-beta-catenin-mediated hyperproliferation in the azoxymethane-treated rat model and the human colorectal cancer cell line, HT-29. (nih.gov)
The discovery of genes responsible for inherited colorectal cancer syndromes has been important in identifying important etiologic pathways such as the beta-catenin/ APC and TGF beta/SMAD pathways. (cdc.gov)

The relationship between long non-coding RNAs and Wnt/β-catenin signaling pathway in the pathogenesis of Alzheimer's disease. (nih.gov)
Overloaded axial stress activates the Wnt/β-Catenin pathway in nucleus pulposus cells of adult degenerative scoliosis combined with intervertebral disc degeneration. (nih.gov)
Of the many growth factors involved in these events, Wnts are particularly interesting regulators, because a key component of their signaling pathway, beta-catenin, also functions as a component of the cadherin complex, which controls cell-cell adhesion and influences cell migration. (nih.gov)
Wnt signaling, proceeding through Frizzled and Arrow-LRP-5/6, activates Dishevelled (Dsh), which results in uncoupling β-catenin from the degradation pathway and its entry into the nucleus, where it interacts with TCF/LEF to control transcription. (nih.gov)
Our previous study showed that LGR5 functions as a tumor promoter in cervical cancer by activating the Wnt/ β -catenin pathway. (nature.com)
Finally, we found that the increased tumorsphere-forming efficiency induced by LGR5 could be regulated through the inhibition or activation of the Wnt/ β -catenin pathway in cervical cancer cells. (nature.com)
5. Constitutive activation of Wnt/beta-catenin signaling pathway in migration-active melanoma cells: role of LEF-1 in melanoma with increased metastatic potential. (nih.gov)
Page and his colleagues predict that PTEN and Wnt-beta-catenin signaling act in a common pathway to control brain growth trajectory via cell number, and that this network may be a point of vulnerability in a subset of individuals with autism and abnormal brain growth. (sfari.org)
Beta-catenin participates in signal transduction and developmental patterning in Xenopus and Drosophila embryos as a component of the Wnt signaling pathway. (embl.de)

9. Chromatin-specific regulation of LEF-1-beta-catenin transcription activation and inhibition in vitro. (nih.gov)

PEG did not alter total beta-catenin expression but rather its nuclear localization, leading us to assess E-cadherin expression (a major determinant of beta-catenin subcellular localization), which was increased by 73% and 71% in the azoxymethane-rat and HT-29 cells, respectively. (nih.gov)
To define which cells respond to activated beta-catenin during mammalian development, we generated the beta-catenin-activated transgene driving expression of nuclear beta-galactosidase reporter (BAT-gal) transgenic mice, expressing the lacZ gene under the control of beta-cateninT cell factor responsive elements. (ox.ac.uk)
Here, we demonstrate that phosphofructokinase 1 platelet isoform (PFKP), which catalyzes a rate-limiting reaction in glycolysis, promotes EGFR activation-induced nuclear translocation and activation of β-catenin, thereby enhancing the expression of its downstream genes CCND1 and MYC in human glioblastoma cells. (frontiersin.org)
EGFR activation-induced and CK2α-mediated α-catenin phosphorylation releases β-catenin from the β-catenin/α-catenin protein complex whereas nuclear pyruvate kinase M2 (PKM2) associates with β-catenin and induces gene expression by direct phosphorylation of histone H3 ( 12 - 17 ). (frontiersin.org)
In addition, AKT directly phosphorylates β-catenin at Ser552 (S552), which promotes nuclear translocation and transactivation of β-catenin ( 18 ). (frontiersin.org)
Catenina multifuncional que participa en la ADHESIÓN CELULAR y en la señalización nuclear. (bvsalud.org)
A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. (bvsalud.org)

It is now clear that Armadillo and beta-catenin bind directly to members of the T-cell factor/lymphoid enhancer factor subfamily of HMG box DNA-binding proteins, forming bipartite transcription factors that regulate Wingless/Wnt responsive genes in both Drosophila and vertebrates. (embl.de)

Molecular studies showed that the spectrum of beta-catenin mutations was markedly different in chlorophyllin-promoted colon tumors--many of the mutations led to direct substitutions of critical Ser/Thr residues within the glycogen synthase kinase-3beta (GSK-3beta) region, whereas in all other groups, including DMH and IQ controls, the mutations typically affected amino acids adjacent to Ser(33). (nih.gov)

The adenomatous polyposis coli tumor suppressor protein is also implicated in beta-catenin signaling. (embl.de)

2. Lef/Tcf-dependent Wnt/beta-catenin signaling during Xenopus axis specification. (nih.gov)

β-catenin can be activated not only by Wnt ligands but also by receptor tyrosine kinases, such as epidermal growth factor receptor (EGFR), whose mutation or overexpression of EGFR gene occurs in many types of human cancer, including more than 50% of glioblastoma (GBM) ( 10 , 11 ). (frontiersin.org)
Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. (embl.de)

Mapping Wnt/beta-catenin signaling during mouse development and in colorectal tumors. (ox.ac.uk)
The carcinogens 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 1,2-dimethylhydrazine (DMH) induce colon tumors in the rat that contain mutations in beta-catenin, but the mutation pattern can be influenced by exposure to dietary phytochemicals, such as the water-soluble derivative of chlorophyll called chlorophyllin. (nih.gov)
Importance of P-cadherin, beta-catenin, and Wnt5a/frizzled for progression of melanocytic tumors and prognosis in cutaneous melanoma. (uib.no)

Importantly, we showed that EGFR-phosphorylated PFKP Y64 has a critical role in AKT activation and AKT-mediated β-catenin S552 phosphorylation and subsequent β-catenin transactivation and promotion of tumor cell glycolysis, migration, invasion, proliferation, and brain tumor growth. (frontiersin.org)
19. A GSK3beta phosphorylation site in axin modulates interaction with beta-catenin and Tcf-mediated gene expression. (nih.gov)

11. Visualization and exploration of Tcf/Lef function using a highly responsive Wnt/β-catenin signaling-reporter transgenic zebrafish. (nih.gov)

Promotion versus suppression of rat colon carcinogenesis by chlorophyllin and chlorophyll: modulation of apoptosis, cell proliferation, and beta-catenin/Tcf signaling. (nih.gov)

These findings highlight a novel mechanism underlying a glycolytic enzyme-mediated β-catenin transactivation and underscore the integrated and reciprocal regulation of metabolism and gene expression, which are two fundamental biological processes in tumor development. (frontiersin.org)

In lipoprotein receptor-related protein 6-null homozygous mice, which lack a Wnt coreceptor, BAT-gal staining is absent in mutant tissues, indicating that BAT-gal mice are bona fide in vivo indicators of Wntbeta-catenin signaling. (ox.ac.uk)
Identification of ESE1 as a β-Catenin Binding Protein. (nih.gov)
The protein cleaves cell-adhesion molecules at the slit diaphragm, leading to Wnt/ β -catenin signaling and podocyte loss. (lww.com)

10. Fluorescence-based functional assay for Wnt/beta-catenin signaling activity. (nih.gov)

In summary, BAT-gal mice unveil the entire complexity of Wntbeta-catenin signaling in mammals and have broad application potentials for the identification of Wnt-responsive cell populations in development and disease. (ox.ac.uk)

β-catenin promotes resistance to trastuzumab in breast cancer cells through enhancing interaction between HER2 and SRC. (nih.gov)

The cylindrical structure features a positively charged grove, which presumably interacts with the acidic surfaces of the known interaction partners of beta-catenin. (embl.de)

Retraction Note: Combination Cancer Immunotherapy with Dendritic Cell Vaccine and Nanoparticles Loaded with Interleukin-15 and Anti-beta-catenin siRNA Significantly Inhibits Cancer Growth and Induces Anti-Tumor Immune Response. (bvsalud.org)

Testing this hypothesis will involve mapping beta-catenin activity in the developing PTEN haploinsufficient mouse brain and modulating beta-catenin activity in a PTEN haploinsufficient background. (sfari.org)

Wntbeta-catenin signaling plays key roles in several developmental and pathological processes. (ox.ac.uk)

Detaching necrotic cells also often lost beta-catenin and e-cadherin expression. (cdc.gov)

Here, we assemble evidence of possible interrelations between Wnt and other growth factor signaling, beta-catenin functions, and cadherin-mediated adhesion. (nih.gov)
They hypothesize that PTEN haploinsufficiency alters brain growth trajectory and scaling of neuronal and glial populations through elevated beta-catenin signaling. (sfari.org)
Beta-catenin is essential for cadherin-based cell adhesion and Wnt/Wingless growth factor signaling. (embl.de)

these data directly implicate beta-catenin/LEF misregulation as the major cause of hair matrix cell tumorigenesis in humans. (medscape.com)

In some necrotic foci in the mainstem bronchus epithelium, the normal thin linear staining of beta-catenin at intercellular junctions was replaced by more focal globular expression. (cdc.gov)

β-catenin transactivation leads to enhanced T-cell factor (TCF)/lymphoid enhancer factor (LEF)-driven transcription of genes, such as CCND1 (encoding cyclin D1) and MYC (encoding c-Myc) ( 7 - 9 ). (frontiersin.org)

The central role of β-catenin in Wnt signaling and the cadherin complex. (nih.gov)
Within the past year, Armadillo and beta-catenin's role in transducing the Wingless/Wnt signal has been substantially clarified. (embl.de)

A core region of beta-catenin, composed of 12 copies of a 42 amino acid sequence motif known as an armadillo repeat, mediates these interactions. (embl.de)

Signal transduction of beta-catenin. (embl.de)

In human skin , DCXR localizes to the cytoplasm near the adhesion molecules, e-cadherin and beta-catenin. (cdc.gov)

Wnt/β-catenin signalling can be controlled by secreted Wnt antagonists, many of which are downregulated in cancer. (cicbiogune.es)

In plakoglobin arm repeats bind alpha-catenin and N-cadherin. (embl.de)
Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. (bvsalud.org)

Anatomy10

Diseases6

Chemicals and Drugs44

Analytical, Diagnostic and Therapeutic Techniques and Equipment7

Phenomena and Processes10

Disciplines and Occupations1

Information Science2

Alzheimer's disease: clues from flies and worms. (1/5919)

The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin. (2/5919)

Axin prevents Wnt-3a-induced accumulation of beta-catenin. (3/5919)

Glucocorticoid down-regulation of fascin protein expression is required for the steroid-induced formation of tight junctions and cell-cell interactions in rat mammary epithelial tumor cells. (4/5919)

Frequent nuclear/cytoplasmic localization of beta-catenin without exon 3 mutations in malignant melanoma. (5/5919)

Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway. (6/5919)

Cadherin-11 is expressed in invasive breast cancer cell lines. (7/5919)

Coupling assembly of the E-cadherin/beta-catenin complex to efficient endoplasmic reticulum exit and basal-lateral membrane targeting of E-cadherin in polarized MDCK cells. (8/5919)

beta Catenin

Catenins

alpha Catenin

Cytoskeletal Proteins

Cadherins

Intestinal Polyps

Trans-Activators

Axin Signaling Complex

gamma Catenin

Peutz-Jeghers Syndrome

Wnt Proteins

Wilms Tumor

Adenomatous Polyposis Coli

Desmoplakins

Tumor Markers, Biological

Interleukin-1beta

Signal Transduction

Cell Nucleus

Adherens Junctions

Neoplasm Proteins

Cytoplasm

Immunoenzyme Techniques

Cell Adhesion Molecules

beta 2-Microglobulin

Immunohistochemistry

Colorectal Neoplasms

Cell Adhesion

Adenocarcinoma

Phosphoproteins

Receptors, Adrenergic, beta

Integrin beta3

Prognosis

Transforming Growth Factor beta

Armadillo Domain Proteins

Cell Line

Desmosomal Cadherins

Cells, Cultured

Intercellular Junctions

Integrin alpha5beta1

Glycogen Synthase Kinase 3

Integrin beta4

Integrin alpha6beta4

Integrin beta Chains

beta 2-Glycoprotein I

Integrin alpha4beta1

Phosphorylation

Integrin alpha2beta1

Receptors, Adrenergic, beta-2

rhoA GTP-Binding Protein

Transfection

RNA, Messenger

rac1 GTP-Binding Protein

Precipitin Tests

Blotting, Western

Protein Transport

Integrins

Interleukin-1

Antigens, CD29

Molecular Sequence Data

Integrin alpha6beta1

Cell Movement

Base Sequence

Epithelial Cells

Protein Binding

Receptors, Adrenergic, beta-1

Desmogleins

Fluorescent Antibody Technique

Mutation

Integrin alpha1beta1

Blood-Air Barrier

Binding Sites

rho GTP-Binding Proteins

Axin Protein

Recombinant Proteins

Recombinant Fusion Proteins

Cell Line, Tumor

Cytoskeleton

Alzheimer's disease: clues from flies and worms. (1/5919)

The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin. (2/5919)

Axin prevents Wnt-3a-induced accumulation of beta-catenin. (3/5919)