Thiourea: A photographic fixative used also in the manufacture of resins. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance may reasonably be anticipated to be a carcinogen (Merck Index, 9th ed). Many of its derivatives are ANTITHYROID AGENTS and/or FREE RADICAL SCAVENGERS.beta-Aminoethyl Isothiourea: A radiation-protective agent that can inhibit DNA damage by binding to the DNA. It also increases the susceptibility of blood cells to complement-mediated lysis.Sodium-Calcium Exchanger: An electrogenic ion exchange protein that maintains a steady level of calcium by removing an amount of calcium equal to that which enters the cells. It is widely distributed in most excitable membranes, including the brain and heart.Aminoethylphosphonic Acid: An organophosphorus compound isolated from human and animal tissues.Ethyl Methanesulfonate: An antineoplastic agent with alkylating properties. It also acts as a mutagen by damaging DNA and is used experimentally for that effect.Interleukin-1beta: An interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein. Proteolytic processing of the precursor form by CASPASE 1 results in release of the active form of interleukin-1beta from the membrane.Triazenes: Compounds with three contiguous nitrogen atoms in linear format, H2N-N=NH, and hydrocarbyl derivatives.SulfonesBoron Compounds: Inorganic or organic compounds that contain boron as an integral part of the molecule.Mesylates: Organic salts or esters of methanesulfonic acid.beta 2-Microglobulin: An 11-kDa protein associated with the outer membrane of many cells including lymphocytes. It is the small subunit of the MHC class I molecule. Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. Beta 2-microglobulin is present in small amounts in serum, csf, and urine of normal people, and to a much greater degree in the urine and plasma of patients with tubular proteinemia, renal failure, or kidney transplants.Nitroso CompoundsEthylaminesCysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.Nitric Oxide Donors: A diverse group of agents, with unique chemical structures and biochemical requirements, which generate NITRIC OXIDE. These compounds have been used in the treatment of cardiovascular diseases and the management of acute myocardial infarction, acute and chronic congestive heart failure, and surgical control of blood pressure. (Adv Pharmacol 1995;34:361-81)Peptide Nucleic Acids: DNA analogs containing neutral amide backbone linkages composed of aminoethyl glycine units instead of the usual phosphodiester linkage of deoxyribose groups. Peptide nucleic acids have high biological stability and higher affinity for complementary DNA or RNA sequences than analogous DNA oligomers.Receptors, Adrenergic, beta: One of two major pharmacologically defined classes of adrenergic receptors. The beta adrenergic receptors play an important role in regulating CARDIAC MUSCLE contraction, SMOOTH MUSCLE relaxation, and GLYCOGENOLYSIS.Integrin beta3: An integrin beta subunit of approximately 85-kDa in size which has been found in INTEGRIN ALPHAIIB-containing and INTEGRIN ALPHAV-containing heterodimers. Integrin beta3 occurs as three alternatively spliced isoforms, designated beta3A-C.EthylenediaminesAmides: Organic compounds containing the -CO-NH2 radical. Amides are derived from acids by replacement of -OH by -NH2 or from ammonia by the replacement of H by an acyl group. (From Grant & Hackh's Chemical Dictionary, 5th ed)rho-Associated Kinases: A group of intracellular-signaling serine threonine kinases that bind to RHO GTP-BINDING PROTEINS. They were originally found to mediate the effects of rhoA GTP-BINDING PROTEIN on the formation of STRESS FIBERS and FOCAL ADHESIONS. Rho-associated kinases have specificity for a variety of substrates including MYOSIN-LIGHT-CHAIN PHOSPHATASE and LIM KINASES.Serine Proteinase Inhibitors: Exogenous or endogenous compounds which inhibit SERINE ENDOPEPTIDASES.Kinetics: The rate dynamics in chemical or physical systems.Silanes: Compounds similar to hydrocarbons in which a tetravalent silicon atom replaces the carbon atom. They are very reactive, ignite in air, and form useful derivatives.Pyridines: Compounds with a six membered aromatic ring containing NITROGEN. The saturated version is PIPERIDINES.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Transforming Growth Factor beta: A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.Aspartate Kinase: An enzyme that catalyzes the formation of beta-aspartyl phosphate from aspartic acid and ATP. Threonine serves as an allosteric regulator of this enzyme to control the biosynthetic pathway from aspartic acid to threonine. EC 2.7.2.4.Bibliometrics: The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)Heart-Assist Devices: Small pumps, often implantable, designed for temporarily assisting the heart, usually the LEFT VENTRICLE, to pump blood. They consist of a pumping chamber and a power source, which may be partially or totally external to the body and activated by electromagnetic motors.Publications: Copies of a work or document distributed to the public by sale, rental, lease, or lending. (From ALA Glossary of Library and Information Science, 1983, p181)Anxiety Disorders: Persistent and disabling ANXIETY.PennsylvaniaResearch: Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.NaphthyridinesPatents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.ButanonesPentanols: Isomeric forms and derivatives of pentanol (C5H11OH).Inventions: A novel composition, device, or process, independently conceived de novo or derived from a pre-existing model.Gordonia Bacterium: A genus of gram-positive BACTERIA in the family Gordoniaceae, isolated from soil and from sputa of patients with chest disorders. It is also used for biotransformation of natural products.Estrenes: Unsaturated derivatives of the ESTRANES with methyl groups at carbon-13, with no carbon at carbon-10, and with no more than one carbon at carbon-17. They must contain one or more double bonds.Spiro Compounds: A group of compounds consisting in part of two rings sharing one atom (usually a carbon) in common.Gallic Acid: A colorless or slightly yellow crystalline compound obtained from nutgalls. It is used in photography, pharmaceuticals, and as an analytical reagent.Directories as Topic: Lists of persons or organizations, systematically arranged, usually in alphabetic or classed order, giving address, affiliations, etc., for individuals, and giving address, officers, functions, and similar data for organizations. (ALA Glossary of Library and Information Science, 1983)DirectoryLocation Directories and Signs: Directory signs or listings of designated areas within or without a facility.Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring.Salvia miltiorrhiza: A plant species which is known as an Oriental traditional medicinal plant.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Fraud: Exploitation through misrepresentation of the facts or concealment of the purposes of the exploiter.

Differential activity of NO synthase inhibitors as chemopreventive agents in a primary rat tracheal epithelial cell transformation system. (1/19)

A model to study the effectiveness of potential chemopreventive agents that inhibit neoplastic process by different mechanisms has been used to test the efficacy of seven nitric oxide synthase (NOS) inhibitors. Five selective inducible NOS (iNOS) inhibitors: S-methyl isothiourea (S-MITU), S-2-aminoethyl isothiourea (S-2-AEITU), S-ethyl isothiourea (S-EITU), aminoguanidine (AG), 2-amino-4-methyl pyridine (2-AMP), and two non selective general NOS inhibitors: l-N(6)-(1-iminoethyl) lysine (IEL) and N(omega)-nitro-l-arginine (NNLA), were tested for efficacy against a carcinogen, benzo[a]pyrene (B[a]P)-induced primary rat tracheal epithelial (RTE) cell transformation assay. RTE cells were treated with B[a]P alone or with five nontoxic concentrations of an NOS inhibitor and the resulting foci at the end of 30 days were scored for inhibition of transformation. The results indicate that all three isothiourea compounds inhibited B[a]P-induced RTE foci in a dose-dependent manner. S-AEITU was the most effective inhibitor with an IC(50) (the molar concentration that inhibits transformation by 50%) of 9.1 microM and 100% inhibition at the highest dose tested (30 microM). However, both S-EITU and S-MITU showed a maximum percent inhibition of 81% and 100% at 1 mM with an IC(50) of 84 and 110 microM, respectively. 2-AMP did not show any dose-dependent response, but was highly effective (57% inhibition) at an intermediate dose of 30 microM and an IC(50) of 25 microM. Similar to thiourea compounds, AG exhibited good dose-dependent inhibition with a maximum inhibition of 86% at 1 mM. NNLA and IEL were negative in this assay. Based on the IC(50) values, NOS inhibitors were rated for efficacy from high to low as follows: S-2-AEITU<2-AMP+info)

A case of small-cell Sezary's syndrome with null-cell features. (2/19)

A case of the small-cell variant of Sezary's syndrome (SS) is reported in which the SS cells lacked the surface-marker characteristics of both T- and B-cells. In particular, the SS cells failed to form E-rosettes even with a sensitive technique using 2-amino-ethylisothiouronium bromide (AET)-treated sheep red blood cells. The significance of these findings is briefly considered in relation to the existing literature.  (+info)

Induction of the paroxysmal nocturnal hemoglobinuria phenotype in normal human erythrocytes: effects of 2-aminoethylisothiouronium bromide on membrane proteins that regulate complement. (3/19)

To investigate the mechanism by which treatment of normal human erythrocytes with the sulfhydryl reagent 2-aminoethylisothiouronium bromide (AET) induces susceptibility to complement mediated lysis, the effects of AET on the structural and functional integrity of decay accelerating factor (DAF), membrane inhibitor of reactive lysis (MIRL), and complement receptor type 1 (CR1) were examined. Following treatment with AET, erythrocyte MIRL and CR1 were no longer recognized in situ by antibodies, and antibody binding to DAF was diminished by approximately 50%. These studies indicated that the structural integrity of the three complement regulatory proteins was either partially (DAF) or completely (MIRL and CR1) disrupted by AET. Subsequent experiments showed that functional inactivation paralleled the structural disruption. Treatment of normal erythrocytes with AET induced susceptibility to cobra venom factor-initiated hemolysis, indicating that the functional activity of MIRL had been destroyed. The capacity of erythrocyte CR1 to serve as a cofactor for factor I-mediated cleavage of iC3b to C3c and C3dg was lost following treatment with AET. C3 convertase activity increase markedly following treatment of erythrocytes with AET, but convertase activity on AET cells was approximately 50% less than that observed when DAF function on normal cells was completely inhibited by antibody. Susceptibility of AET cells to acidified serum lysis was shown to be due primarily to inactivation of MIRL. Unexpectedly, in acidified serum the activity of the amplification C3 convertase of the APC was found to be controlled by MIRL as well as by DAF. These studies show that AET induces susceptibility to complement-mediated lysis by disrupting the structural and functional integrity of membrane constituents that regulate the activity of both the C3 convertases and the membrane attack complex of complement.  (+info)

The role of nitric oxide in radiation damage. (4/19)

This study investigated the role of nitric oxide in radiation-induced damage by examining changes in mouse serum nitrate concentrations after irradiation. In addition, the contribution of S-2-aminoethylisothiourea 2HBr (AET) to the mechanisms of radiation damage protection was also clarified. The serum nitrate concentration increased as soon as 1.5 h after irradiation, and after 2.5 to 3.0 h the concentrations were significantly higher compared with normal levels. Normal levels were re-established after 12 h. Post-irradiation serum nitrate concentrations increased dose-dependently with irradiation dose (19.6-31.5 Gy). AET suppressed increases in the serum nitrate concentration following irradiation while 2-mercaptoethylamine HCl (MEA) did not. AET has an inhibitory effect on inducible nitric oxide synthase (iNOS); therefore, the increase in nitric oxide after irradiation may be produced by iNOS. Combined administration of irradiation and lipopolysaccharide (LPS) induced a significant increase in serum nitrate concentration, and a significant decrease in survival rate, compared with irradiation alone. The administration of AET or aminoguanidine increased survival rate following irradiation. In contrast to findings after LPS administration, IL-1beta and IFN-gamma were not determined in serum following irradiation. Existing iNOS is activated by irradiation, and nitric oxide production appears to increase without iNOS induction. Thus, the irradiation-induced increase in nitric oxide may be related to lethal injury.  (+info)

Immunoblotting human C4 bound to human erythrocytes in vivo and in vitro. (5/19)

A study of C4 bound to human erythrocytes in vitro and in vivo has been made by immunoblotting with mouse monoclonal anti-C4c and anti-C4d and human polyclonal anti-C4d (Rodgers and Chido) following SDS-PAGE. Multi-banded patterns differentiated between C4A and C4B isotypes. Treatment of EC4b with trypsin eliminated immunoblotting but not agglutination reactions. Serum inactivation (factor I) of EC4b resulted in banding patterns similar to those obtained from patients' EC4d. Treatment of EC4b membranes with NH2OH affected many of the bands, two were lost, one was markedly reduced and others had altered SDS-PAGE mobility. Interpretation of the bands has been made in terms of C4-acceptor complexes and inactivation fragments of C4. A distinct difference in the banding of C4A and C4B isotypes has been detected.  (+info)

Tumor rejection in experimental animals treated with radioprotective thiols. (6/19)

In experimental animals, a systemic treatment with thiols of the mercaptoalkylamine type has affected all of five solid tumors so far investigated. (Three of the tumors were transplanted into the strain of origin.) There was either inhibition of growth or "oncodieresis," i.e., a necrosis and sloughing of tumors conducive to full recovery and repair. Mercaptoalkylamines and derivatives of the type used in our experiments are known to bind to cellular sites by a two-point attachment involving both thiol and amino groups. One of these compounds, cysteamine, was active in its native, unsubstituted form, but did not bring about oncodieresis when either the amino or thiol group, or both, were alkylated. Mercaptopropylamine, the 3-carbon homolog of cysteamine, was less active. Cystamine, a disulfide dimer of cysteamine that has no free reactive sulfhydryl, did not induce any reaction. Thioglycerol, lacking a terminal amino group, had only negligible activity. Rejection was much more striking when treatment was started on the day of inoculation than when started 7 days later. Male mice rejected better than females. Results were inferior when tow of the agents were given simultaneously or together with other radioprotectants, such as L-cysteine, glutathione, dimethyl sulfoxide, or reserpine. Tumor rejection was enhanced when the phosphorylated thioyls, S-2-(3-aminopropylamino)ethylphosphorothioic acid or S-(2-ethylguanidine)phosphorothioci acid, were given simultaneously with the radioprotective serotonin, but there was no synergy of serotonin with the nonphosphorylated compounds S-2-aminoethylisothiouronium bromide or cysteamine. Serotonin alone did not affect the tumors.  (+info)

Characterization of the complement sensitivity of paroxysmal nocturnal hemoglobinuria erythrocytes. (7/19)

The affected erythrocytes of paroxysmal nocturnal hemoglobinuria (PNH II and PNH III cells) are abnormally sensitive to complement-mediated lysis. Normal human erythrocytes chemically modified by treatment with 2-amino-ethylisothiouronium bromide (AET) have been used as models for PNH cells inasmuch as they also exhibit an enhanced susceptibility to complement. To investigate the bases for the greater sensitivity of these abnormal cells to complement-mediated lysis, we compared binding of C3 and constituents of the membrane attack complex to normal, PNH II, PNH III, and AET-treated cells after classical pathway activation by antibody and fluid-phase activation by cobra venom factor complexes. When whole serum complement was activated by antibody, there was increased binding of C3 and C9 to PNH II, PNH III, and AET-treated cells, although the binding of these complement components to PNH II and PNH III cells was considerably greater than their binding to the AET-treated cells. In addition, all of the abnormal cell types showed a greater degree of lysis per C9 bound than did the normal erythrocytes. PNH III and AET-treated cells were readily lysed by fluid-phase activation of complement, whereas normal and PNH II erythrocytes were not susceptible to bystander lysis. The greater hemolysis of PNH III and AET-treated cells in this reactive lysis system was due to a quantitative increase in binding of constituents of the membrane attack complex. This more efficient binding of the terminal components after fluid-phase activation of whole serum complement was not mediated by cell-bound C3 fragments. These investigations demonstrate that the molecular events that characterize the enhanced susceptibility of PNH II, PNH III, and AET-treated erythrocytes to complement-mediated lysis are heterogeneous.  (+info)

Tissue NAD levels and the response to irradiation of cytotoxic drugs. (8/19)

It has been shown that when (32)P counting from a tumour is continuous peaks in the count rate can sometimes be induced by large doses of nicotinic acid, nicotinic acid, nicotinamide or 3-acetylpyridine, but not by 6-aminonicotinamide. These (32)P counting peaks have been associated with the time of maximal new synthesis of nicotinamide adenine dinucleotide (NAD). Sensitization to irradiation or some cytotoxic drugs has been found at the peak of this new NAD synthesis. The radioprotective agents cysteamine, 2-aminoethylisothiouronium bromide (AET) and serotonin have been found to cause a rapid fall in tissue NAD levels. The results have been briefly discussed.  (+info)

... , UOP AET 550 Week , AET 550, UOP AET 550, AET 550, UOP AET 550, AET 550 Week 1,2,3,4,5,6 AET 550 Tutorials, AET 550 Free, AET 550 Assignments
The distribution and the chemical nature of the protective agent in the various tissues of C57BL/6J male tumor-bearing mice given a protective dose of either of two forms of the radiation-protective agent S-(2-aminoethyl)thiuronium bromide hydrobromide (AET) were studied. The mice carried a subcutaneously transplanted mammary adenocarcinoma. Results at 20 minutes after an I.P. injection of 140 or 280 mg/kg 2-mercaptoethylguanidine (MEG) and at 20 or 120 minutes after an I.P. injection of 140 mg/kg bis(2-guanidoethyl) disulfide (GED) were obtained. At 20 minutes the tumor took up less protective agent than did most of the vital organs except brain. The tumor contained the same S35-labeled chemical compounds that normal tissues contained. The concentration of GED in the tumor was the only form which correlated with protection of the tumor against the effects of local irradiation. As compared with normal animals, tumor-bearing animals appeared to have difficulty excreting the protective agent. It ...
Round 2 [Aug 16] IK Sirius 1-1 Hammarby IF [aet, 4-3 pen] [Aug 18] Enskede IK 0-1 Landskrona BoIS IK Frej 2-1 Trelleborgs FF L rje/Angereds IF 1-1 sters IF [aet, 2-3 pen] IFK Uddevalla 0-7 Syrianska FC Kristianstads FF 1-2 Falkenbergs FF Nyk pings BIS 5-3 IF Brommapojkarna [aet] Ronneby BK 2-5 Halmstads BK IFK H ssleholm 0-2 Ume FC Karlstad BK 0-0 Gefle IF [aet, 3-4 pen] stersunds FK 0-3 Mj llby AIF Raml sa S dra FF 0-7 Assyriska FF Rynninge IK 0-2 IFK Norrk ping Aram./Syr. Botkyrka 1-3 GIF Sundsvall Valsta Syrianska IK 0-1 IK Brage [Aug 19] Sel nger FK 0-6 Ljungskile SK Mariehem SK 0-2 rebro SK Motala AIF 1-2 Varbergs BoIS Torns IF 1-2 ngelholms FF karps IF 0-3 BK H cken rgryte IS 3-0 Degerfors IF R sl tt SK 2-3 IFK V rnamo Sk vde AIK 0-3 tvidabergs FF Utsiktens BK 0-3 GAIS IK Sleipner 0-2 J nk pings S dra IF [aet] [Aug 20] Dalstorps IF 1-5 Djurg rdens IF FC Gute 0-4 Kalmar FF L ngholmen FC 0-9 IFK G teborg Sandvikens IF 3-6 Malm FF [aet] [Sep 12] Torslanda IK 0-1 AIK [Nov 11] FC H llviken 1-2 ...
The AET62 from Advanced Card Systems combines fingerprint scanner with contactless smart card reader. A swipe fingerprint sensor from UPEK is used in the device. The same sensor is available in the Eikon fingerprint reader. The contactless (RFID/NFC) smart card reader supports ISO 14443 (Type A and B), MIFARE, FeliCa, and ISO 18092 (NFC) tags. Support modules for this scanner are included in MegaMatcher 11.2 SDK, MegaMatcher On Card 11.2 SDK and VeriFinger 11.2 SDK. ...
Russell, J H.; Masakowski, V; Rucinsky, T; and Phillips, G, "Mechanisms of immune lysis. Iii. Characterization of the nature and kinetics of the cytotoxic t lymphocyte-induced nuclear lesion in the target." (1982). Subject Strain Bibliography 1982. 2733 ...
Pravastatin AET is a medicine available in a number of countries worldwide. A list of US medications equivalent to Pravastatin AET is available on the Drugs.com website.
see article for more reactions. Abstract. A clean and economic synthesis of alkanesulfonyl chlorides via bleach-mediated oxidative chlorosulfonation of S-alkyl isothiourea salts is simple, environment- and worker-friendly. The procedure uses readily accessible reagents, offers safe operations and easy purification without chromatography, and affords high yields.. ...
The V-Fit AET2 Air Elliptical Trainer is suitable for all abilities and fitness levels. It provides a great total body workout helping you tone up and get in shape.
AET, composed of hormone-blocking drugs such as tamoxifen or aromatase inhibitors, is associated with a 29% reduction in the risk of death for hormone-receptor-positive breast cancer patients. The authors of a study, published recently in JAMA Oncology, approximate that 14,630 women who did not receive hormone treatment died unnecessarily between 2004 and 2013 due to recurrence of their malignancies.. Although adherence to guidelines for AET following surgery had slowly improved over the 10-year study period, by the end of the study, 18% of women that could have benefited from the potentially life-saving therapy were not receiving treatment. Researchers also discovered that approximately 3% of women inappropriately received AET despite lacking the required hormone receptors.. "The use of adjuvant endocrine therapy slowly gained popularity over this time," commented senior author Dezheng Huo (University of Chicago, IL, US). "It improved after 2004, rising from 70% in 2004 to almost 84 % in 2011. ...
Onsite wastewater systems are a significant source of nutrient loading to the environment and there is a demand for technologies that remove nutrients at the source. Most desired are passive, low-cost systems that can consistently remove 90 percent or greater nitrogen while having low energy input and easy operation. While numerous proprietary devices have been developed that typically employ multiple mechanical apparatus, they require active attention and provide only partial nitrogen removal. AET is developing a unique multi-chamber treatment process that provides high percent nitrogen removal, passive operation, low life cycle cost, and resilient performance. The AET process applies anaerobic biological treatment in a multi-chamber upflow solids blanket bioreactor to remove organics and recover energy, followed by a selectively configured ion adsorption, aerobic and anaerobic biofilter that employs judiciously specified designer media. No operation energy is required. Nitrogen and phosphorus ...
Dr. Guenther Wachsmuth. 1932 245p. Numerous Diagrams INCLUDING 48 COLOR PAGES. Another Primary & Important Contributor To The Steiner Ethereal Science School. Highly Recommended! Contents: Quantitative & Qualitative Observations Of The World; Character Of Legitimate & Of Illegitimate Hypotheses; Fundamentals Of A New Theory Of Motion; Organic & Inorganic World; Second Riddle Of The Universe, According To Du Bois Reymond; Will & Motion; Being & Phenomena; Etheric Formative Forces; States Of Aggregation Of Substance & The Etheric Formative Forces; Earth Organism; Etheric Life Phenomena Of The Earth Organism & Their Relation To The Human Organism; Chaos & Order; Waking & Sleeping; Breathing Process Of The Earth Organism; Barometric Pressure; Breathing Of Earth Organism & Of The Human Organism; Vertical Current; Potential Gradient; Emanation; Humidity; Rising & Galling Of Sap In The Plants; Three Great Rhythms Of The Plant World; Circulatory Process Of Earth Organism; Rotation Of Earth; Heliotropism ...
postfix sasl confpostfix,code,(#source,/code,(ftp://ftp.porcupine.org#source=(ftp://ftp.aet.tu-cottbus.de/pub/postfixtls/pfixtls-0.8.18-2.1.3-0.9.7d.tar.gz ftp://ftp.porcupine.org# #cd \$startdir/src/\$pkgname-\$pkgver#cd \$startdir/src/\$pkgname-\$pkgver\npatch -p1 , ../pfixtls-0.8.18-2.1.3-0.9.7d/pfixtls.diff# #make OPT#make CCARGS,code,\-DUSESASLAUTH -I/usr/include/sasl -DUSE_SSL -I/usr/include/openssl\ AUXLIBS,/code,\-L/usr/lib -R/usr/lib -lsasl2 -lssl -lcrypto\ OPT# ...
postfix sasl confpostfix,code,(#source,/code,(ftp://ftp.porcupine.org#source=(ftp://ftp.aet.tu-cottbus.de/pub/postfixtls/pfixtls-0.8.18-2.1.3-0.9.7d.tar.gz ftp://ftp.porcupine.org# #cd \$startdir/src/\$pkgname-\$pkgver#cd \$startdir/src/\$pkgname-\$pkgver\npatch -p1 , ../pfixtls-0.8.18-2.1.3-0.9.7d/pfixtls.diff# #make OPT#make CCARGS,code,\-DUSESASLAUTH -I/usr/include/sasl -DUSE_SSL -I/usr/include/openssl\ AUXLIBS,/code,\-L/usr/lib -R/usr/lib -lsasl2 -lssl -lcrypto\ OPT# ...
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Nicotinamide Adenine Dinucleotide (NAD+) which is an essential molecule found in every living cell. Boosting NAD+ levels promote cellular metabolism, mitochondrial function and energy production.
This only serves to further illustrate what i just said, a complete misunderstanding of evolution. The fossil record shows that we humans shared a common ancestor with some of the primates; the great apes. DNA supports this, with our closest extant relatives being Chimpanzees and Bonobos, Orang-Utans and Gorillas. Transitional forms support this. Just even looking at evidence available today supports this; our skeletons, our shared teeth formation, our brain size in relation to our bodies, our skulls, opposable thumbs. the fact we also have an appendix, though unused now in humans, that it is still used by our closest relatives because of their mostly herbivorous diets. Our chromosome (the organised structure of DNA and protein in all cells) sequence of 23 pairs, rather than 24 pairs as with the other primates, and the fact that humans show a fused second chromosome, which shows a link between us and the other great apes, since it is suggestive that we formerly had, also, 24 pairs. We retain the ...
Biological aging is associated with progressive damage accumulation, loss of organ reserves, and systemic inflammation (inflammaging), which predispose for a wide spectrum of chronic diseases, including several types of cancer. In contrast, aerobic exercise training (AET) reduces inflammation, lowers all-cause mortality, and enhances both health and lifespan. In this study, we examined the benefits of early-onset, lifelong AET on predictors of health, inflammation, and cancer incidence in a naturally aging mouse model. Lifelong, voluntary wheel-running (O-AET; 26-month-old) prevented age-related declines in aerobic fitness and motor coordination vs. age-matched, sedentary controls (O-SED). AET also provided partial protection against sarcopenia, dynapenia, testicular atrophy, and overall organ pathology, hence augmenting the physiologic reserve of lifelong runners. Systemic inflammation, as evidenced by a chronic elevation in 17 of 18 pro- and anti-inflammatory cytokines and chemokines, was ...
Biodesix, Inc. announced that its VeriStrat® test is now considered a medically necessary benefit by Aetna Corporation (NYSE: AET). Aetna published a positive coverage policy for the VeriStrat proteomic test on June 5th, stating the test is medically necessary "for patients with advanced NSCLC, whose tumors were without EGFR and anaplastic lymphoma kinase (ALK) mutations…" Aetnas […]. ...
|b|Portugal 1-0 France (aet)|/b||br /|Portugal shrugged off an early injury to Cristiano Ronaldo to claim a first-ever major tournament trophy thanks to Éders 109th-minute strike.
i have just passed the psychometric tests for the AET, its interview next -does anyone have any tips for this , not answers to questions but what type...
Two sets of diagnostic criteria of paediatric multiple organ dysfunction syndrome (MODS) were published by Proulx in 1996 and by Goldstein in 2005. We hypothesized that this changes the epidemiology of MODS. Thus, we determined the epidemiology of MODS, according to these two sets of diagnostic criteria, we studied the intra- and inter-observer reproducibility of each set of diagnostic criteria, and we compared the association between cases of MODS at paediatric intensive care unit (PICU) entry, as diagnosed by each set of diagnostic criteria, and 90-day all-cause mortality. All consecutive patients admitted to the tertiary care PICU of Sainte-Justine Hospital, from April 21, 2009 to April 20, 2010, were considered eligible for enrolment into this prospective observational cohort study. The exclusion criteria were gestational age | 40 weeks, age | 3 days or | 18 years at PICU entry, pregnancy, admission immediately after delivery. No patients were censored. Daily monitoring using medical chart ended
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Defects and discontinuities in a material must be detected before they reach a critical size and result in severe damage and expensive corrective actions, according to the company.. Acoustic emission (AE) occurs naturally where external stimuli, such as deformations, corrosion and cracks in a material under stress, generate sound waves.. AET is an advanced non-destructive-testing (NDT) method that is used to analyse the sound waves emitted, caused by defects or discontinuities in material.. Several sensors are attached to the surface of the material, spaced at intervals of a number of metres apart.. The information collected by each of the sensors is monitored by a computer.. If there is a defect in the material, the signal characteristics of the sensor attached near the discontinuity alters.. Information about the origin and severity of a defect in the material can be ascertained by analysing these signals.. AET is said to provide an increase in sensitivity compared to conventional testing ...
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PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Cultured human melanoma cells M10 harvested from cultures in different phases of their growth show significant changes in the expression of melanoma-associated antigens (MAA), but they do not vary in susceptibility to lysis mediated by anti-MAA xenoantisera and effected by complement or lymphoid cells. Furthermore, melanoma cells M10 showed a significant increase in susceptibility to immune lysis following treatment with puromycin at doses that do not effect the expression of MAA. The lack of correlation between MAA density and susceptibility to immune lysis supports the contention that, under the experimental conditions used, cellular properties play a major role in the outcome of immune attack.. ...
1HDF: Crystal Structure of the Calcium-Loaded Spherulin 3A Dimer Sheds Light on the Evolution of the Eye Lens Betagamma-Crystallin Domain Fold
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This gene encodes an enzyme which catalyzes a key step in the biosynthesis of the coenzyme NAD. The encoded protein is one of several nicotinamide nucleotide adenylyltransferases. Studies in Drosophila and mammalian neurons have shown the encoded protein can confer protection to damaged neurons. This protection requires enzymatic activity which increases NAD levels and activates a nuclear deacetylase which is the protective molecule. Pseudogenes of this gene are located on chromosomes 1, 3, 4, 14 and 15 ...
To confirm you have PNH, your doctor will send a sample of your blood to a specialist laboratory to check whether it contains any PNH blood cells using a test called "flow cytometry". This shows the percentage of red and white PNH cells in your blood. It is more accurate for white blood cells during or just after you have had an episode of haemolysis or a blood transfusion. ...
TY - JOUR. T1 - New or Progressive Multiple Organ Dysfunction Syndrome in Pediatric Severe Sepsis. T2 - A Sepsis Phenotype With Higher Morbidity and Mortality. AU - Sepsis Prevalence, Outcomes, and Therapy Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators Network. AU - Lin, John C.. AU - Spinella, Philip C.. AU - Fitzgerald, Julie C.. AU - Tucci, Marisa. AU - Bush, Jenny L.. AU - Nadkarni, Vinay M.. AU - Thomas, Neal J.. AU - Weiss, Scott L.. AU - Fontela, P.. AU - Tucci, M.. AU - Dumistrascu, M.. AU - Skippen, P.. AU - Krahn, G.. AU - Bezares, E.. AU - Puig, G.. AU - Puig-Ramos, A.. AU - Garcia, R.. AU - Villar, M.. AU - Bigham, M.. AU - Polanski, T.. AU - Latifi, S.. AU - Giebner, D.. AU - Anthony, H.. AU - Hume, J.. AU - Galster, A.. AU - Linnerud, L.. AU - Sanders, R.. AU - Hefley, G.. AU - Madden, K.. AU - Thompson, A.. AU - Shein, S.. AU - Gertz, S.. AU - Han, Y.. AU - Williams, T.. AU - Hughes-Schalk, A.. AU - Chandler, H.. AU - Orioles, A.. AU - Zielinski, ...
Objective. The broad objective of this exploratory project is to inform clinical studies and trials on the use of aerobic exercise training (AET) as an intervention for improving cardiorespiratory fitness in patients with traumatic brain injury (TBI). AET-induced adaptation of cardiorespiratory fitness and fatigue severity will be characterized, and time-course for changes in mood reactivity will be determined. We hypothesize that 1) AET will improve both cardiorespiratory fitness and fatigue severity 2) mood will at first worsen in response to AET but that mood reactivity will then decrease at some point during the intervention, and 3) AET will not impair overall cognitive performance, but that the specific cognitive performance areas of attention and concentration will improve with AET.. Study Population. Thirty-six adult subjects with a clinical diagnosis of non-penetrating TBI (mild, moderate, and severe) will be enrolled. Subjects will be recruited from NIH, affiliated hospitals/clinics, ...
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Once in the bloodstream NAD+ was thought to be too large to cross the cell membrane, making it ineffective at restoring the NAD+ contents inside the cells of many tissues. In this article we show that is not true for heart and brain, and perhaps other tissues.. In fact, this research published in March 2018 shows NAD+ is able to cross the blood brain barrier and quickly increases levels of NAD+ in the hypothalamus, while NR and NMN do not.. Administration of 1 mg/kg of NAD+ reduced hunger and weight gain, and increases energy expenditure and fat burning in mice (r).. Elevating NAD+ levels the hypothalamus has great impact throughout the body, as it regulates hunger and energy expenditure.. Restoring NAD+ levels in the hypothalamus to those of a young animal is very likely to have a positive impact on organs and tissues throughout the body.. ...
Systemic inflammatory response syndrome (SIRS), as a consequence of mechanical or surgical trauma, organ transplantation, or bacterial infection per se (i.e., sepsis), is a common clinical problem leading to substantial morbidity and mortality in intensive care units worldwide. One of the key features of SIRS/sepsis is an overwhelming production of proinflammatory mediators (e.g., cytokines) in the circulation and an accumulation of PMNs (neutrophils) in affected systemic organs. While PMN recruitment to the afflicted sites is an entirely normal host response to remove pathogens or dead tissue, the overwhelming accumulation of PMNs and subsequent production of cytotoxic ROS and the release of proteolytic enzymes contribute significantly to the development of multiple organ dysfunction syndrome (MODS) (9).. Given the complexity and acute nature of SIRS and sepsis, it is perhaps not surprising that little progress has been made in improving the overall outcome. Efforts to block one or another ...
TALK=T;RUN(1,1) PHOTON USE p; ; ; ; ; cl;gr ou z 1 msg Contours of temperature T1 con tem1 z 1 fi;0.005 ; pause pause cl;gr ou z 1 msg Contours of coefficients APCO: con apt1 k 1 fi;0.005 pause cl;gr ou z 1 msg Contours of coefficients AECO: con aet1 k 1 fi;0.005 pause cl;gr ou z 1 msg Contours of coefficients AWCO: con awt1 k 1 fi;0.005 pause cl;gr ou z 1 msg Contours of coefficients ANCO: con ant1 k 1 fi;0.005 pause cl;gr ou z 1 msg Contours of coefficients ASCO: con ast1 k 1 fi;0.005 pause cl;gr ou z 1 msg Contours of residuals of temperature RES: con tres k 1 fi;0.005 pause cl;gr ou z 1 msg Contours of temperature corrections CORR: con tcor k 1 fi;0.005 pause AUTOPLOT file phi 5 aphi 2 data 1 tem1 y 2 col3 1 data 1 tem1 y 6 colf 2 data 2 dist anal BLB4 3 REDR msg Tem1 at y=2 Blue ; at y=6 Red ;Analytic solution Crosses ENDUSE DISPLAY This case uses the geometry and finer grid volumes of F308. Temperatures at opposite boundaries along x-direction is fixed as boundary conditions. The solution ...
Αἰτωλός). The son of Endymion, who founded Elis and Iphianassa. Having accidentally killed Apis, son of Phoroneus, he fled with a band of followers into the country which afterwards was called, in his honour, Aetolia (q.v.). See Apollod. i.7.6. ...
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In the present study we established that NAMPT is the molecular target of the GMX1778 small-molecule cancer therapeutic candidate. A global metabolic profiling study was instrumental in the discovery that NAD+ levels were rapidly depleted in GMX1778-treated cells. NAD+ depletion was followed by ATP depletion and ultimately resulted in cell death. Previous results suggested that the mechanism of action of GMX1778 involved the inhibition of IKK leading to decreased NF-κB activity (24). However, our results show that the inhibition of IKK and the subsequent inhibition of NF-κB activity in cells following GMX1778 treatment are secondary to the initial NAD+ depletion, since it can be recovered by restoration of NAD+ levels. Furthermore, NAD+ repletion completely rescues cells from the cytotoxicity of GMX1778. There appears to be a threshold level of NAD+ required to protect cells from GMX1778 cytotoxicity, given that NMN supplementation only partially restores the cellular NAD+ levels while ...
Anchorage resident forms jewelry company and receives design patents.. Promising entrepreneur and Alaska resident, Mr. Courtney Larsen, recently received his fourth design patent. As an engaged bachelor in the spring of 2005, Courtney took it upon himself to design his own wedding ring. Then, through a meticulous search, he located a jeweler that could manufacture the structurally unique design.. The wedding ring shape and form is based on design principles taught in architectural school as an architecture student at the University of Utah (B.S. Architectural Studies, 1999) and drafted in 3-D CAD with skills learned as an Architectural and Engineering Technology (AET) student at the University of Alaska Anchorage (Architectural Drafting Certificate, 2006). One of the requirements to obtain an architectural drafting certificate in the AET program included learning 3-D drafting and design.. Ring and bride in hand, Courtney started a business selling a line of eternal band rings based off the ...
The present invention provides an improved means for regulating the immune response, for ameliorating effects of stress, and for avoiding untoward effects of chemotherapy or exposure to irradiation by administration of androstenediol (AED) and androstenetriol (AET). The improved means of regulating immune response can be utilized in treating infectious diseases and immune diseases such as diabetes and chronic fatigue syndrome, both diseases now considered to be immune response related syndromes.
Biodesix, Inc. announced that its VeriStrat® test is now considered a medically necessary benefit by Aetna Corporation (NYSE: AET). Aetna published a positive coverage policy for the VeriStrat proteomic test on June 5th, stating the test is medically necessary "for patients with advanced NSCLC, whose tumors were without EGFR and anaplastic lymphoma kinase (ALK) mutations…" Aetnas […]. ...
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Hoffmann, E. M. et al "Resistance of Sheep Erythrocytes to Immune Lysis by Treatment of the Cells with a Human Erythrocyte Extract: Studies on the Site of Inhibition." The Journal of Immunology 113.5 (1974): 1501-1509. Web. 23 Feb. 2018. ...
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Factors Affecting the Applicability of the Aet Model for Decomposition in Arid Environments PDF By author Elkins, N. Z., Y. Steinberger and W. G. Whitford last download was at 2016-11-13 55:09:59. This book is good alternative for Factors Affecting the Adsorption of Proteins on Wyoming Bentonite . Download now for free or you can read online Factors Affecting the Applicability of the Aet Model for Decomposition in Arid Environments book ...
Khalilou Fadigas hooked shot beats Rustu Recber but is stopped by Camara. He turns and fires the ball in the net but it is rightly ruled out as the striker received the ball in an offside position. 16 mins: Henri Camara creates a bit of excitement in the stadium as he creates some space for himself and fires in the first shot of the match which Rustu Recber saves easily. 13 mins: The game becomes a bit scrappy and there are a few hard challenges coming in. The match is failing to live up to its early promise. 11 mins: The 33-year-old referee shows the first yellow card of the match. Omar Daf is the aggressor and Yildiray Basturk the victim, but it is not a malicious tackle. 10 mins: The match seems to be settling as Senegal now enjoy a passage of possession as they probe for an opening. Both teams are looking comfortable and confident on the ball. 9 mins: Turkey are playing precise possession football deep in Senegal territory but there is no end product. 7 mins: It is end-to-end stuff with ...
a bit long. Have patience with me aet. Im old; it takes me a while to set the focus on the microscope …. The Wall. So, the efficiency part of the system has been built out as far as it can be. To do so, The US provided artificial demand to Europe, the US and Europe provided artificial demand to the BRICs, Europe and the BRICs provided artificial supply to the US, the BRICs provided artificial supply to Europe, and now the BRICs are trying to provide both artificial supply and demand for everyone, entering Africa to complete the loop, using GDP = I + C + G + (E-I), economic activity, which is a supply-side loss leader. Thats the gravitational field.. The scarcity assumption has been proven invalid. If you look at the numbers, we can easily provide food, shelter, and clothing for everyone, requiring no one to work more than 20 hrs/wk, and we can pay the people that do not want to work to stay home, so long as they do not reproduce. The planet can and will replace us if we do not increase ...
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This volume reviews the fundamental understanding of this potentially life-threatening disease and the advances in treatment that have been achieved with the use of the monoclonal antibody eculizumab. Although the PIGA gene has been known for many years, the mechanism of clonal dominance in paroxysmal nocturnal hemoglobinuria is still largely unknown. This book, Paroxysmal Nocturnal Hemoglobinuria, discusses the direction of continuing research in this area, as well as the potential for the development of management guidelines. It serves as a valuable source of information for both basic scientists and physicians, especially immunologists targeting GPI-anchored proteins and complements, and hematologists specializing in bone marrow failure. ...
Paroxysmal Nocturnal Haemoglobinuria (PNH) is an acquired hematopoietic stem-cell disorder related to the somatic mutation in PIG-A gene (X-chromosome). This genetic alteration results in partial or total deficiency of all proteins normally linked to the cell membrane by glycosylphosphatidyl-inositol (GPI). Flow cytometry provides an efficient diagnostic test in which the lack of GPI-anchored proteins is studied on the major blood cell populations ...
Paroxysmal Nocturnal Haemoglobinuria (PNH) is an acquired hematopoietic stem-cell disorder related to the somatic mutation in PIG-A gene (X-chromosome). This genetic alteration results in partial or total deficiency of all proteins normally linked to the cell membrane by glycosylphosphatidyl-inositol (GPI). Flow cytometry provides an efficient diagnostic test in which the lack of GPI-anchored proteins is studied on the major blood cell populations ...
Paroxysmal nocturnal haemoglobinuria (PNH) is a unique disorder in which a substantial proportion of the patients red cells have an abnormal susceptibility to activated complement. This results from the presence of a clone that originates from a haematopoietic stem cell bearing an acquired somatic mutation in the X-linked gene ...
Learn about paroxysmal nocturnal hemoglobinuria. What are the symptoms, the causes and how to treat this condition? What can we do to cope...
Heinz bodies are intraerythrocytic inclusions of hemichrome formed as a result of hemoglobin (Hb) oxidation. They typically develop in aged red cells. Based on the hypothesis that hemichrome formation is an innate characteristic of physiologically normal Hb molecules, we present an overview of our previous findings regarding the molecular instability of Hb and the formation of hemichrome, as well as recent findings on Heinz body formation within normal human erythrocytes. Human adult Hb (HbO2 A) prepared from healthy donors showed a tendency to produce hemichrome, even at close to physiological temperature and pH. Recent studies found that the number of Heinz bodies formed in red cells increased with increasing temperature when freshly drawn venous blood from healthy donors was subjected to mild heating above 37 °C. These findings suggest that Hb molecules control the removal of non-functional erythrocytes from the circulation via hemichrome formation and subsequent Heinz body clustering. In this
I believe that a story is the shortest distance between two people. While this is my story, it is not just mine, and I did not do any of this alone. In April 1983, my husband Joe and I were 25 years old and attending to the required pre-marital blood work. Next thing we knew, we were sitting in a doctors office because my blood counts were abnormally low. They told us there was something wrong, but they didnt know what it was. ...
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PNH seems to be a different type of disease. Here the PNH cell is not attacked because of a molecule it has, but rather, because of ... proteins (such as CD55 and CD59) normally prevent the red cell from being broken down by complement proteins. In a way, PNH could also be .... Research Review last updated 05/02/2016 - 9:26am.. ...
Paroxysmal nocturnal hemoglobinuria: Find the most comprehensive real-world symptom and treatment data on paroxysmal nocturnal hemoglobinuria at PatientsLikeMe. 9 patients with paroxysmal nocturnal hemoglobinuria experience fatigue, depressed mood, pain, anxious mood, and insomnia.
BACKGROUND: The exercise intolerance in chronic heart failure with reduced ejection fraction (HFrEF) is mostly attributed to alterations in skeletal muscle. However, the mechanisms underlying the skeletal myopathy in patients with HFrEF are not completely understood. We hypothesized that (i) aerobic exercise training (AET) and inspiratory muscle training (IMT) would change skeletal muscle microRNA-1 expression and downstream-associated pathways in patients with HFrEF and (ii) AET and IMT would increase leg blood flow (LBF), functional capacity, and quality of life in these patients. METHODS: Patients age 35 to 70 years, left ventricular ejection fraction (LVEF) ≤40%, New York Heart Association functional classes II-III, were randomized into control, IMT, and AET groups. Skeletal muscle changes were examined by vastus lateralis biopsy. LBF was measured by venous occlusion plethysmography, functional capacity by cardiopulmonary exercise test, and quality of life by Minnesota Living with Heart ...
Paroxysmal nocturnal hemoglobinuria (PNH) In this condition, the bone marrow--the soft spongy tissue that act as the blood manufacturing system for the entire body--produces defective red blood cells. The bodys natural defense system then destroys these defective red blood cells in a process is known as hemolysis.
Feldman L. Triiodothyronine (T3) toxicosis and paroxysmal nocturnal hemoglobinuria: report of case. J Am Osteopath Assoc 1981;80(7):491. doi: 10.7556/jaoa.1981.80.7.491.. Download citation file:. ...
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Definition of Epidemic haemoglobinuria with photos and pictures, translations, sample usage, and additional links for more information.
Paroxysmal Nocturnal Hemoglobinuria - Epidemiology Insights to 2025 is a market research report available at US $2950 for a Single User PDF License from RnR Market Research Reports Library.
Multiple organ dysfunction syndrome (MODS), also often known as multiple organ failure (MOF) is the clinical manifestation of the tissue injury affecting various organs, whatever the mechanism, infectious or not, during very severe insults in particularly severe shock states. The objective of this chapter is to review the definition, epidemiology, pathophysiology and clinical aspects of MODS/MOF in septic patients as well as non-infectious Systemic Inflammatory Response Syndrome (SIRS) patients. ...
Sepsis is the systemic inflammatory response to infection and can result in multiple organ dysfunction syndrome with associated high mortality, morbidity and health costs. Erythropoietin is a well-established treatment for the anaemia of renal failure due to its anti-apoptotic effects on red blood cells and their precursors. The extra-haemopoietic actions of erythropoietin include vasopressor, anti-apoptotic, cytoprotective and immunomodulating actions, all of which could prove beneficial in sepsis. Attenuation of organ dysfunction has been shown in several animal models and its vasopressor effects have been well characterised in laboratory and clinical settings. Clinical trials of erythropoietin in single organ disorders have suggested promising cytoprotective effects, and while no randomised trials have been performed in patients with sepsis, good quality data exist from studies on anaemia in critically ill patients, giving useful information of its pharmacokinetics and potential for harm. An
Worldwide, cardiac surgery is a common procedure requiring a large quantity of allogeneic blood products, which are associated with postoperative complications. Leukocytes present in blood products may play a role in these complications, which are referred to as transfusion-related immunomodulation (TRIM). Several randomized controlled trials (RCTs) in different settings investigated the effects of allogeneic leukocytes in red blood cells (RBCs). Cardiac surgery studies reported a reduction in postoperative infections and mortality in patients that received leukocyte-reduced RBCs compared with leukocyte-containing RBCs; this was mainly due to more deaths due to infections and multiple organ dysfunction syndrome (MODS) in the group that received leukocyte-containing RBCs. Patients with postoperative complications had higher concentrations of inflammatory mediators. These findings suggest that leukocyte-containing transfusion during cardiac surgery induces a second insult to the systemic ...
Speaking with your healthcare team about your condition and finding out what you can about the disease can be empowering and can help you understand how best to move forward. OneSource is a complimentary, personalized patient support program offered by Alexion, and tailored to the specific needs of people living with aHUS, gMG, HPP, LAL-D, NMOSD and PNH. Were here to help you learn, and were here to help you understand the options available to you.. ...
N-Acyl imidazoles and catalytic isothiourea hydrochloride salts function as ammonium enolate precursors in the absence of base. Enantioselective Michael addition-cyclization reactions using different α,β-unsaturated Michael acceptors have been performed to form dihydropyranones and dihydropyridinones with high stereoselectivity. Detailed mechanistic studies using RPKA have revealed the importance of the "imidazolium" effect in ammonium enolate formation and have highlighted key differences with traditional base-mediated processes ...
Jonathan says that I should be on the cautious side on the bike: after all this is double the distance of a Half Ironman (duh!). My Achilles heel is heat and humidity tolerance and I have had a couple of races where I have overdone it and ended up suffering at the hands of the dreaded cramps. On the other hand, if I dont push it too hard, the run has every possibility of being fast and, perhaps more importantly, actually enjoyable in a sort of Ironman kind of way. All the same, Im still not as confident with my heart rate zones and exertion on the bike so the idea is to not strictly adhere to a pulse rate but to go by feeling to some extent. Being prudent, this feeling should correspond to about a quarter way between AeT (128 bpm) and AT (156 bpm), or about 135 bpm - or, in reference to my training, half way between where I did 90% of my rides and the medium intensity (CMED). There are a couple of small hills on the course, which are pathetic by Madrid standards but can, nevertheless, send ...
List of Publicly Traded Companies Headquartered in Connecticut. The companies on this list are headquartered in Connecticut. Examples of some of the larger companies on this list based on market capitalization include:. Aetna Inc. (AET). Alexion Pharmaceuticals, Inc. (ALXN). Amphenol Corporation (APH). Charter Communications, Inc. (CHTR). Cigna Corporation (CI). Hartford Financial Services Group, Inc. (The) (HIG). Interactive Brokers Group, Inc. (IBKR). Praxair, Inc. (PX). Synchrony Financial (SYF). The Priceline Group Inc. (PCLN). United Technologies Corporation (UTX). Xerox Corporation (XRX). Select the companys link to access charts, news links and company website and social media information.. Aerospace and Defense. Hexcel Corporation (HXL) (Composites company: composite materials, parts and structures used in commercial and military aircraft, helicopters, launchers and satellites). Kaman Corporation (KAMN) (Helicopter service, systems, components and support; engineering design analysis, ...
68133-57-3 - XANFTJNZNYVTRE-UHFFFAOYSA-N - 1,2-Ethanediamine, N1-(2-aminoethyl)-, 4-methylbenzenesulfonate (1:?) - Similar structures search, synonyms, formulas, resource links, and other chemical information.
Learn more about N-(2-Aminoethyl)-N-(4-methylbenzyl)amine. We enable science by offering product choice, services, process excellence and our people make it happen.
Mohamed Kharfan-Dabaja, MD, discusses the future of PNH treatment, the various symptoms that can present in PNH, and the challenges that still remain for further improving outcomes.
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AccuWeather.com provided daily cold and flu weather forecast in Montclair Township, NJ. See how the weather will impact the flu and common cold
The plasma membrane Ca2+ ATPase (PMCA) is a transport protein in the plasma membrane of cells and functions to remove calcium (Ca2+) from the cell. PMCA function is vital for regulating the amount of Ca2+ within all eukaryotic cells. There is a very large transmembrane electrochemical gradient of Ca2+ driving the entry of the ion into cells, yet it is very important that they maintain low concentrations of Ca2+ for proper cell signalling. Thus, it is necessary for cells to employ ion pumps to remove the Ca2+. The PMCA and the sodium calcium exchanger (NCX) are together the main regulators of intracellular Ca2+ concentrations. Since it transports Ca2+ into the extracellular space, the PMCA is also an important regulator of the calcium concentration in the extracellular space. PMCAs belong to the family of P-type primary ion transport ATPases which form aspartyl phosphate intermediates. Various forms of PMCA are expressed in different tissues, including the brain. The pump is powered by the ...
A ground-coupled heat exchanger is an underground heat exchanger that can capture heat from and/or dissipate heat to the ground. They use the Earth's near constant subterranean temperature to warm or cool air or other fluids for residential, agricultural or industrial uses. If building air is blown through the heat exchanger for heat recovery ventilation, they are called earth tubes (also known as earth cooling tubes or earth warming tubes) in Europe or earth-air heat exchangers (EAHE or EAHX) in North America. These systems are known by several other names, including: air-to-soil heat exchanger, earth channels, earth canals, earth-air tunnel systems, ground tube heat exchanger, hypocausts, subsoil heat exchangers, thermal labyrinths, underground air pipes, and others. Earth tubes are often a viable and economical alternative or supplement to conventional central heating or air conditioning systems since there are no compressors, chemicals or burners and only blowers are required to move the ...
A regenerative heat exchanger, or more commonly a regenerator, is a type of heat exchanger where heat from the hot fluid is intermittently stored in a thermal storage medium before it is transferred to the cold fluid. To accomplish this the hot fluid is brought into contact with the heat storage medium, then the fluid is displaced with the cold fluid, which absorbs the heat. In regenerative heat exchangers, the fluid on either side of the heat exchanger can be the same fluid. The fluid may go through an external processing step, and then it is flowed back through the heat exchanger in the opposite direction for further processing. Usually the application will use this process cyclically or repetitively. Regenerative heating was one of the most important technologies developed during the Industrial Revolution when it was used in the hot blast process on blast furnaces, It was later used in glass and steel making, to increase the efficiency of open hearth furnaces, and in high pressure boilers and ...
... s and phosphonic acids are organophosphorus compounds containing C−PO(OH)2 or C−PO(OR)2 groups (where R = alkyl, aryl). Phosphonic acids, typically handled as salts, are generally nonvolatile solids that are poorly soluble in organic solvents, but soluble in water and common alcohols. Many commercially important compounds are phosphonates, including glyphosate, the herbicide "Roundup", and ethephon, a widely used plant growth regulator. Bisphosphonates are popular drugs for treatment of osteoporosis. In biology and medicinal chemistry, phosphonate groups are used as stable bioisoteres for phosphate, such as in the antiviral nucleotide analogue, Tenofovir, one of the cornerstones of anti-HIV therapy. Phosphonates feature tetrahedral phosphorus centers. They are structurally closely related to (and often prepared from) phosphorous acid. Phosphonate salts are the result of deprotonation of phosphonic acids, which are diprotic acids: RPO(OH)2 + NaOH → H2O + RPO(OH)(ONa) (monosodium ...
An encore is when performers in a live show give an additional performance after the planned show has ended, usually in response to extended applause from the audience. Multiple encores are not uncommon, and they originated spontaneously, when audiences would continue to applaud and demand additional performance from the artist(s). At the end of a concert, if there is prolonged applause, one more relatively short piece may be performed as an encore. In some modern circumstances, encores have come to be expected, and artists often plan their encores. Traditionally, in a concert that has a printed set list for the audience, encores are not listed, even when they are planned. A well-known example is the performance of the Radetzky March and The Blue Danube at the end of the Vienna New Year's Concert by the Vienna Philharmonic Orchestra; neither piece is ever listed in the official program, but they are traditionally played every year. Beginning in the 18th century, if an aria was strongly ...
... , often referred to as ASC (Apoptosis-associated speck-like protein containing a CARD), is a protein that in humans is encoded by the PYCARD gene. It is localized mainly in the nucleus of monocytes and macrophages. In case of pathogen infection, however, it relocalizes rapidly to the cytoplasm, perinuclear space, endoplasmic reticulum and mitochondria and it is a key adaptor protein in activation of the inflammasome . NMR structure of full-length ASC: PDB ID 2KN6 [1] This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ...
An interleukin receptor is a cytokine receptor for interleukins. There are two main families of Interleukin receptors, type 1 and type 2 cytokine receptors. Type 1 interleukin receptors include: Interleukin-2 receptor Interleukin-3 receptor Interleukin-4 receptor Interleukin-5 receptor Interleukin-6 receptor Interleukin-7 receptor Interleukin-9 receptor Interleukin-11 receptor Interleukin-12 receptor Interleukin-13 receptor Interleukin-15 receptor Interleukin-21 receptor Interleukin-23 receptor Interleukin-27 receptor Type 2 interleukin receptors include: Interleukin-10 receptor Interleukin-20 receptor Interleukin-22 receptor Interleukin-28 receptor Interleukin-1 receptor and interleukin-18 receptor belong to the immunoglobulin superfamily. Interleukin-8 receptor, RANTES receptors (CCR1, CCR3, CCR5), MIP-1 receptor, PF4 receptor, M-CSF receptor and NAP-2 receptor belong to the chemokine receptor family. Subramaniam S, Stansberg C, Cunningham C (May 2004). "The interleukin 1 receptor family". ...
Caspase-1/Interleukin-1 converting enzyme (ICE) is an evolutionarily conserved enzyme that proteolytically cleaves other proteins, such as the precursors of the inflammatory cytokines interleukin 1β and interleukin 18 as well as the pyroptosis inducer Gasdermin D, into active mature peptides. It plays a central role in cell immunity as an inflammatory response initiator. Once activated through formation of an inflammasome complex, it initiates a proinflammatory response through the cleavage and thus activation of the two inflammatory cytokines, interleukin 1β (IL-1β) and interleukin 18 (IL-18) as well as pyroptosis, a programmed lytic cell death pathway, through cleavage of Gasdermin D. The two inflammatory cytokines activated by Caspase-1 are excreted from the cell to further induce the inflammatory response in neighboring cells. Caspase-1 is evolutionarily conserved in many Eukaryotes of the Kingdom Animalia. Due to its role in the inflammatory immune response, it is highly expressed in the ...
Beta, named after the second letter of the Greek alphabet, is the software development phase following alpha. Software in the beta stage is also known as betaware.[6] A Beta phase generally begins when the software is feature complete but likely to contain a number of known or unknown bugs.[7] Software in the beta phase will generally have many more bugs in it than completed software, speed or performance issues, and may still cause crashes or data loss. The focus of beta testing is reducing impacts to users, often incorporating usability testing. The process of delivering a beta version to the users is called beta release and this is typically the first time that the software is available outside of the organization that developed it. Software beta releases can either be public or private, depending on whether they are openly available or only available to ...
... is a name that can be given to any herbal product advertised as treating erectile dysfunction. There are many different products advertised as herbal viagra, but with varying ingredients. There are no clinical trials or scientific studies that support the effectiveness of any of these ingredients for the treatment of erectile dysfunction and some products have been found to contain drugs and other adulterants, and have been the subject of FDA and FTC warnings and actions to remove them from the market. The name "herbal viagra" is taken from the brand name Viagra, under which drug company Pfizer sells sildenafil citrate, a drug that is used to treat erectile dysfunction. Viagra has become a generic term for many people discussing drugs designed to treat erectile dysfunction, even those which do not contain sildenafil. Herbal viagras, contrary to what the name suggests, do not normally contain sildenafil citrate. However, sildenafil and chemicals similar to sildenafil have been found ...
A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a drug used to block the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells lining the blood vessels supplying the corpus cavernosum of the penis. These drugs are used in the treatment of erectile dysfunction and were the first effective oral treatment available for the condition. Because PDE5 is also present in the arterial wall smooth muscle within the lungs, PDE5 inhibitors have also been explored for the treatment of pulmonary hypertension, a disease in which blood vessels in the lungs become overloaded with fluid, usually as a result of failure of the right ventricle of the heart. PDE5 inhibitors such as sildenafil (Viagra), tadalafil (Cialis), and vardenafil (Levitra) are clinically indicated for the treatment of erectile dysfunction. Sildenafil and tadalafil are also indicated for the treatment of pulmonary hypertension. Sildenafil, the prototypical PDE5 inhibitor, was ...
... (DCDPS) is an organic compound with the formula (ClC6H4)2SO2. Classified as a sulfone, this white solid is most commonly used as a precursor to polymers that are rigid and temperature resistant such as PES or Udel. DCDPS is synthesized via sulfonation of chlorobenzene with sulfuric acid, often in the presence of various additives to optimize the formation of the 4,4'-isomer: ClC6H5 + SO3 → (ClC6H4)2SO2 + H2O It can also be produced by chlorination of diphenylsulfone. DCDPS is the starting material in the polymerization of compounds such as Udel, PES and Radel R. The polymerization occurs through a nucleophilic substitution reaction of DCDPS with difunctional nucleophiles. With bisphenol A in dimethyl sulfoxide, DCDPS forms a material called Udel. This and related condensations adhere to the following stoichiometry: (ClC6H4)2SO2 + HO-X-OH → 1/n [(O-X-OC6H4)2SO2]n + 2 HCl Udel is a high performance amorphous sulfone polymer that can molded into a variety of ...
A sulfone is a molecule that has a sulfur atom with bonds to two oxygen atoms. The sulfur has two double bonds to the two oxygens. It has a single bond with the other two groups. They are usually made by oxidising thioethers.. They are used in many important chemical reactions. For example, the Julia olefination uses a sulfone to make an alkene from an aldehyde. They are also sometimes used as solvents.. ...

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