An 11-kDa protein associated with the outer membrane of many cells including lymphocytes. It is the small subunit of the MHC class I molecule. Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. Beta 2-microglobulin is present in small amounts in serum, csf, and urine of normal people, and to a much greater degree in the urine and plasma of patients with tubular proteinemia, renal failure, or kidney transplants.
Serum proteins with an electrophoretic mobility that falls between ALPHA-GLOBULINS and GAMMA-GLOBULINS.
Serum proteins that have the most rapid migration during ELECTROPHORESIS. This subgroup of globulins is divided into faster and slower alpha(1)- and alpha(2)-globulins.
An interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein. Proteolytic processing of the precursor form by CASPASE 1 results in release of the active form of interleukin-1beta from the membrane.
A group of sporadic, familial and/or inherited, degenerative, and infectious disease processes, linked by the common theme of abnormal protein folding and deposition of AMYLOID. As the amyloid deposits enlarge they displace normal tissue structures, causing disruption of function. Various signs and symptoms depend on the location and size of the deposits.
Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during GRAFT REJECTION and restrict cell-mediated lysis of virus-infected cells.
A fibrous protein complex that consists of proteins folded into a specific cross beta-pleated sheet structure. This fibrillar structure has been found as an alternative folding pattern for a variety of functional proteins. Deposits of amyloid in the form of AMYLOID PLAQUES are associated with a variety of degenerative diseases. The amyloid structure has also been found in a number of functional proteins that are unrelated to disease.
A high-molecular-weight protein (approximately 22,500) containing 198 amino acid residues. It is a strong inhibitor of trypsin and human plasmin.
One of two major pharmacologically defined classes of adrenergic receptors. The beta adrenergic receptors play an important role in regulating CARDIAC MUSCLE contraction, SMOOTH MUSCLE relaxation, and GLYCOGENOLYSIS.
An integrin beta subunit of approximately 85-kDa in size which has been found in INTEGRIN ALPHAIIB-containing and INTEGRIN ALPHAV-containing heterodimers. Integrin beta3 occurs as three alternatively spliced isoforms, designated beta3A-C.
Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.
A beta-N-Acetylhexosaminidase that catalyzes the hydrolysis of terminal, non-reducing 2-acetamido-2-deoxy-beta-glucose residues in chitobiose and higher analogs as well as in glycoproteins. Has been used widely in structural studies on bacterial cell walls and in the study of diseases such as MUCOLIPIDOSIS and various inflammatory disorders of muscle and connective tissue.
The major group of transplantation antigens in the mouse.
Poisoning occurring after exposure to cadmium compounds or fumes. It may cause gastrointestinal syndromes, anemia, or pneumonitis.
A pteridine derivative present in body fluids; elevated levels result from immune system activation, malignant disease, allograft rejection, and viral infections. (From Stedman, 26th ed) Neopterin also serves as a precursor in the biosynthesis of biopterin.
A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.
Established cell cultures that have the potential to propagate indefinitely.
Genetic loci in the vertebrate major histocompatibility complex which encode polymorphic characteristics not related to immune responsiveness or complement activity, e.g., B loci (chicken), DLA (dog), GPLA (guinea pig), H-2 (mouse), RT-1 (rat), HLA-A, -B, and -C class I genes of man.
A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*27 allele family.
The combination of hemodialysis and hemofiltration either simultaneously or sequentially. Convective transport (hemofiltration) may be better for removal of larger molecular weight substances and diffusive transport (hemodialysis) for smaller molecular weight solutes.
Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, PERITONEAL DIALYSIS, and HEMODIAFILTRATION.
An integrin found in FIBROBLASTS; PLATELETS; MONOCYTES, and LYMPHOCYTES. Integrin alpha5beta1 is the classical receptor for FIBRONECTIN, but it also functions as a receptor for LAMININ and several other EXTRACELLULAR MATRIX PROTEINS.
Also known as CD104 antigen, this protein is distinguished from other beta integrins by its relatively long cytoplasmic domain (approximately 1000 amino acids vs. approximately 50). Five alternatively spliced isoforms have been described.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
This intrgrin is a key component of HEMIDESMOSOMES and is required for their formation and maintenance in epithelial cells. Integrin alpha6beta4 is also found on thymocytes, fibroblasts, and Schwann cells, where it functions as a laminin receptor (RECEPTORS, LAMININ) and is involved in wound healing, cell migration, and tumor invasiveness.
Integrin beta chains combine with integrin alpha chains to form heterodimeric cell surface receptors. Integrins have traditionally been classified into functional groups based on the identity of one of three beta chains present in the heterodimer. The beta chain is necessary and sufficient for integrin-dependent signaling. Its short cytoplasmic tail contains sequences critical for inside-out signaling.
A 44-kDa highly glycosylated plasma protein that binds phospholipids including CARDIOLIPIN; APOLIPOPROTEIN E RECEPTOR; membrane phospholipids, and other anionic phospholipid-containing moieties. It plays a role in coagulation and apoptotic processes. Formerly known as apolipoprotein H, it is an autoantigen in patients with ANTIPHOSPHOLIPID ANTIBODIES.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Integrin alpha4beta1 is a FIBRONECTIN and VCAM-1 receptor present on LYMPHOCYTES; MONOCYTES; EOSINOPHILS; NK CELLS and thymocytes. It is involved in both cell-cell and cell- EXTRACELLULAR MATRIX adhesion and plays a role in INFLAMMATION, hematopoietic cell homing and immune function, and has been implicated in skeletal MYOGENESIS; NEURAL CREST migration and proliferation, lymphocyte maturation and morphogenesis of the PLACENTA and HEART.
A soluble factor produced by MONOCYTES; MACROPHAGES, and other cells which activates T-lymphocytes and potentiates their response to mitogens or antigens. Interleukin-1 is a general term refers to either of the two distinct proteins, INTERLEUKIN-1ALPHA and INTERLEUKIN-1BETA. The biological effects of IL-1 include the ability to replace macrophage requirements for T-cell activation.
An integrin found on fibroblasts, platelets, endothelial and epithelial cells, and lymphocytes where it functions as a receptor for COLLAGEN and LAMININ. Although originally referred to as the collagen receptor, it is one of several receptors for collagen. Ligand binding to integrin alpha2beta1 triggers a cascade of intracellular signaling, including activation of p38 MAP kinase.
A subclass of beta-adrenergic receptors (RECEPTORS, ADRENERGIC, BETA). The adrenergic beta-2 receptors are more sensitive to EPINEPHRINE than to NOREPINEPHRINE and have a high affinity for the agonist TERBUTALINE. They are widespread, with clinically important roles in SKELETAL MUSCLE; LIVER; and vascular, bronchial, gastrointestinal, and genitourinary SMOOTH MUSCLE.
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
The genetic region which contains the loci of genes which determine the structure of the serologically defined (SD) and lymphocyte-defined (LD) TRANSPLANTATION ANTIGENS, genes which control the structure of the IMMUNE RESPONSE-ASSOCIATED ANTIGENS, HUMAN; the IMMUNE RESPONSE GENES which control the ability of an animal to respond immunologically to antigenic stimuli, and genes which determine the structure and/or level of the first four components of complement.
The presence of proteins in the urine, an indicator of KIDNEY DISEASES.
Antibodies produced by a single clone of cells.
Compounds and molecular complexes that consist of very large numbers of atoms and are generally over 500 kDa in size. In biological systems macromolecular substances usually can be visualized using ELECTRON MICROSCOPY and are distinguished from ORGANELLES by the lack of a membrane structure.
Proteins prepared by recombinant DNA technology.
A group of antigens that includes both the major and minor histocompatibility antigens. The former are genetically determined by the major histocompatibility complex. They determine tissue type for transplantation and cause allograft rejections. The latter are systems of allelic alloantigens that can cause weak transplant rejection.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
A component of the murine major histocompatibility complex class I family. It contains one Ig-like C1-type domain and functions in processing and presentation of exogenous peptide antigens to the immune system.
A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors(RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation.
Integrin beta-1 chains which are expressed as heterodimers that are noncovalently associated with specific alpha-chains of the CD49 family (CD49a-f). CD29 is expressed on resting and activated leukocytes and is a marker for all of the very late activation antigens on cells. (from: Barclay et al., The Leukocyte Antigen FactsBook, 1993, p164)
A cell surface receptor mediating cell adhesion to the EXTRACELLULAR MATRIX and to other cells via binding to LAMININ. It is involved in cell migration, embryonic development, leukocyte activation and tumor cell invasiveness. Integrin alpha6beta1 is the major laminin receptor on PLATELETS; LEUKOCYTES; and many EPITHELIAL CELLS, and ligand binding may activate a number of signal transduction pathways. Alternative splicing of the cytoplasmic domain of the alpha6 subunit (INTEGRIN ALPHA6) results in the formation of A and B isoforms of the heterodimer, which are expressed in a tissue-specific manner.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Long convoluted tubules in the nephrons. They collect filtrate from blood passing through the KIDNEY GLOMERULUS and process this filtrate into URINE. Each renal tubule consists of a BOWMAN CAPSULE; PROXIMAL KIDNEY TUBULE; LOOP OF HENLE; DISTAL KIDNEY TUBULE; and KIDNEY COLLECTING DUCT leading to the central cavity of the kidney (KIDNEY PELVIS) that connects to the URETER.
An element with atomic symbol Cd, atomic number 48, and atomic weight 114. It is a metal and ingestion will lead to CADMIUM POISONING.
A subclass of beta-adrenergic receptors (RECEPTORS, ADRENERGIC, BETA). The adrenergic beta-1 receptors are equally sensitive to EPINEPHRINE and NOREPINEPHRINE and bind the agonist DOBUTAMINE and the antagonist METOPROLOL with high affinity. They are found in the HEART, juxtaglomerular cells, and in the central and peripheral nervous systems.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
The rate dynamics in chemical or physical systems.
Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.
Elements of limited time intervals, contributing to particular results or situations.
Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
Processes involved in the formation of TERTIARY PROTEIN STRUCTURE.
Integrin alpha1beta1 functions as a receptor for LAMININ and COLLAGEN. It is widely expressed during development, but in the adult is the predominant laminin receptor (RECEPTORS, LAMININ) in mature SMOOTH MUSCLE CELLS, where it is important for maintenance of the differentiated phenotype of these cells. Integrin alpha1beta1 is also found in LYMPHOCYTES and microvascular endothelial cells, and may play a role in angiogenesis. In SCHWANN CELLS and neural crest cells, it is involved in cell migration. Integrin alpha1beta1 is also known as VLA-1 and CD49a-CD29.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
A lectin found in ENDOPLASMIC RETICULUM membranes that binds to specific N-linked OLIGOSACCHARIDES found on newly synthesized proteins. It may play role in PROTEIN FOLDING or retention and degradation of misfolded proteins in the endoplasmic reticulum.
Pathological processes of the KIDNEY or its component tissues.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.

A cytomegalovirus glycoprotein re-routes MHC class I complexes to lysosomes for degradation. (1/1648)

Mouse cytomegalovirus (MCMV) early gene expression interferes with the major histocompatibility complex class I (MHC class I) pathway of antigen presentation. Here we identify a 48 kDa type I transmembrane glycoprotein encoded by the MCMV early gene m06, which tightly binds to properly folded beta2-microglobulin (beta2m)-associated MHC class I molecules in the endoplasmic reticulum (ER). This association is mediated by the lumenal/transmembrane part of the protein. gp48-MHC class I complexes are transported out of the ER, pass the Golgi, but instead of being expressed on the cell surface, they are redirected to the endocytic route and rapidly degraded in a Lamp-1(+) compartment. As a result, m06-expressing cells are impaired in presenting antigenic peptides to CD8(+) T cells. The cytoplasmic tail of gp48 contains two di-leucine motifs. Mutation of the membrane-proximal di-leucine motif of gp48 restored surface expression of MHC class I, while mutation of the distal one had no effect. The results establish a novel viral mechanism for downregulation of MHC class I molecules by directly binding surface-destined MHC complexes and exploiting the cellular di-leucine sorting machinery for lysosomal degradation.  (+info)

Impaired lysosomal processing of beta2-microglobulin by infiltrating macrophages in dialysis amyloidosis. (2/1648)

BACKGROUND: Macrophages may participate in amyloid fibril formation by processing the protein precursor. Although this theory seems to apply for amyloidosis, in which proteolytic cleavage is a prerequisite for amyloid fibril formation, it has not been demonstrated for beta2-microglobulin (beta2m) amyloidosis. We aimed to establish the role played by macrophages in beta2m amyloidosis. METHODS: We used a double immunogold electron microscopy technique, including mouse antihuman CD68, rabbit antihuman beta2m, amyloid P component, and lysosome-associated membrane protein (LAMP-1) antibodies. Differential density labeling studies of beta2m and amyloid P component were performed extra- and intracellularly to assess protein processing by macrophages. RESULTS: The cells surrounding amyloid fibrils were found to be mostly CD68 positive, suggesting that they were of monocyte-macrophage lineage. Intracellular accumulation of amyloid fibrils was also observed; these fibrils were constantly surrounded by LAMP-1-linked gold particles, demonstrating that intracellular beta2m was almost exclusively lysosomal. The rough-surface endoplasmic reticulum was not labeled by beta2m antibody, suggesting that there was no active synthesis of beta2m by the cells. As a marker of endocytosis, protruded cytoplasmic processes in close relation with the intracellular accumulations of beta2m amyloid fibrils were observed. No difference in density labeling (extracellular vs. intracellular) was observed for beta2m, whereas intracellular P component labeling was significantly decreased. CONCLUSIONS: All of these data are strongly suggestive of phagocytosis and not synthesis of amyloid fibrils by macrophages. Further, they demonstrate an impaired lysosomal processing specific for beta2m, as other compounds of the amyloid fibrils (P component) are significantly cleared.  (+info)

Photophysical analysis of class I major histocompatibility complex protein assembly using a xanthene-derivatized beta2-microglobulin. (3/1648)

Spectral changes and a sixfold increase in the emission intensity were observed in the fluorescence of a single xanthene probe (Texas red) attached to beta2m-microglobulin (beta2m) upon assembly of beta2m into a ternary complex with mouse H-2Kd heavy chain and influenza nuclear protein peptide. Dissociation of the labeled beta2m from the ternary complex restored the probe's fluorescence and absorption spectra and reduced the emission intensity. Thus changes in xanthene probe fluorescence upon association/dissociation of the labeled beta2m molecule with/from the ternary complex provide a simple and convenient method for studying the assembly/dissociation mechanism of the class I major histocompatibility complex (MHC-I) encoded molecule. The photophysical changes in the probe can be accounted for by the oligomerization of free labeled beta2m molecules. The fluorescence at 610 nm is due to beta2m dimers, where the probes are significantly separated spatially so that their emission and excitation properties are close to those of xanthene monomers. Fluorescence around 630 nm is due to beta2m oligomers where xanthene probes interact. Minima in the steady-state excitation (550 nm) and emission (630 nm) anisotropy spectra correlate with the maxima of the high-order oligomer excitation and emission spectra, showing that their fluorescence is more depolarized. These photophysical features are explained by splitting of the first singlet excited state of interacting xanthene probes that can be modeled by exciton theory.  (+info)

Acute haemodynamic and proteinuric effects of prednisolone in patients with a nephrotic syndrome. (4/1648)

BACKGROUND: Administration of prednisolone causes an abrupt rise in proteinuria in patients with a nephrotic syndrome. METHODS: To clarify the mechanisms responsible for this increase in proteinuria we have performed a placebo controlled study in 26 patients with a nephrotic syndrome. Systemic and renal haemodynamics and urinary protein excretion were measured after prednisolone and after placebo. RESULTS: After i.v. administration of 125-150 mg prednisolone total proteinuria increased from 6.66+/-4.42 to 9.37+/-6.07 mg/min (P<0.001). By analysing the excretion of proteins with different charge and weight (albumin, transferrin, IgG, IgG4 and beta2-microglobulin) it became apparent that the increase of proteinuria was the result of a change in size selectivity rather than a change in glomerular charge selectivity or tubular protein reabsorption. Glomerular filtration rate rose from 83+/-34 ml to 95+/-43 ml/min (P<0.001) after 5 h, whereas effective renal plasma flow and endogenous creatinine clearance remained unchanged. As a result filtration fraction was increased, compatible with an increased glomerular pressure, which probably contributes to the size selectivity changes. Since corticosteroids affect both the renin-angiotensin system and renal prostaglandins, we have evaluated the effects of prednisolone on proteinuria after pretreatment with 3 months of the angiotensin-converting enzyme inhibitor lisinopril or after 2 weeks of the prostaglandin synthesis inhibitor indomethacin. Neither drug had any effect on prednisolone-induced increases of proteinuria. CONCLUSIONS: Prednisolone increases proteinuria by changing the size selective barrier of the glomerular capillary. Neither the renin-angiotensin axis nor prostaglandins seem to be involved in these effects of prednisolone on proteinuria.  (+info)

Stability of plasma levels of cytokines and soluble activation markers in patients with human immunodeficiency virus infection. (5/1648)

Cytokine and immune activation marker levels in plasma are valuable measurements of immune status and treatment effects in human immunodeficiency virus (HIV) infection and AIDS. Five populations representing various stages of disease were studied: controls, 2 AIDS groups with <50/mm3 CD4 cells, and 2 groups of HIV-positive subjects-1 with stable CD4 T cells (median, 545/mm3) and 1 with >100/mm3 CD4 cell decline in 1 year. Relatively stable levels of tumor necrosis factor (TNF)-alpha, soluble TNF receptor (R)II, soluble interleukin-2R, neopterin, and beta2-microglobulin (beta2M) were documented over 5-8 weeks in patients with AIDS and for 1-4 years in the other groups. beta2M was generally the most stable marker. Interferon-gamma levels, however, fluctuated substantially. Individuals, whether normal or HIV-positive, maintain characteristic plasma levels of cytokines and immune activation markers. Thus, documented changes, in excess of the variability observed in this study, are likely to be significant indicators of change in disease status or effects of therapy.  (+info)

Cyclooxygenase-2 expression is up-regulated in human pancreatic cancer. (6/1648)

A large body of evidence suggests that cyclooxygenase-2 (COX-2) is important in gastrointestinal cancer. The purpose of this study was to determine whether COX-2 was expressed in adenocarcinoma of the human pancreas. Quantitative reverse transcription-PCR, immunoblotting, and immunohistochemistry were used to assess the expression of COX-2 in pancreatic tissue. Levels of COX-2 mRNA were increased by >60-fold in pancreatic cancer compared to adjacent nontumorous tissue. COX-2 protein was present in 9 of 10 cases of adenocarcinoma of the pancreas but was undetectable in nontumorous pancreatic tissue. Immunohistochemical analysis showed that COX-2 was expressed in malignant epithelial cells. In cultured human pancreatic cancer cells, levels of COX-2 mRNA and protein were induced by treatment with tumor-promoting phorbol esters. Taken together, these results suggest that COX-2 may be a target for the prevention or treatment of pancreatic cancer.  (+info)

Soluble class I MHC with beta2-microglobulin covalently linked peptides: specific binding to a T cell hybridoma. (7/1648)

Soluble forms of the mouse MHC class I molecule, Dd, were produced in which the peptide binding groove was uniformly occupied by peptides attached via a covalent flexible peptide linker to the N terminus of the associated beta2-microglobulin. The MHC heavy chain and beta2-microglobulin were firmly associated, and the molecules displayed an Ab epitope requiring proper occupancy of the peptide binding groove. Soluble Dd containing a covalent version of a well-characterized Dd-binding peptide from HIV stimulated a T cell hybridoma specific for this combination. Furthermore, a tetravalent version of this molecule bound specifically with apparent high avidity to this hybridoma.  (+info)

Recognition of the major histocompatibility complex restriction element modulates CD8(+) T cell specificity and compensates for loss of T cell receptor contacts with the specific peptide. (8/1648)

Triggering of a T cell requires interaction between its specific receptor (TCR) and a peptide antigen presented by a self-major histocompatibility complex (MHC) molecule. TCR recognition of self-MHC by itself falls below the threshold of detection in most systems due to low affinity. To study this interaction, we have used a read-out system in which antigen-specific effector T cells are confronted with targets expressing high levels of MHC compared with the selecting and priming environment. More specifically, the system is based on CD8(+) T cells selected in an environment with subnormal levels of MHC class I in the absence of beta2-microglobulin. We observe that the MHC restriction element can trigger viral peptide-specific T cells independently of the peptide ligand, provided there is an increase in self-MHC density. Peptide-independent triggering required at least four times the natural in vivo level of MHC expression. Furthermore, recognition of the restriction element at expression levels below this threshold was still enough to compensate for lack of affinity to peptides carrying alanine substitutions in major TCR contact residues. Thus, the specificity in TCR recognition and T cell activation is fine tuned by the avidity for self-MHC, and TCR avidities for peptide and MHC may substitute for each other. These results demonstrate a functional role for TCR avidity for self-MHC in tuning of T cell specificity, and support a role for cross-reactivity on "self" during T cell selection and activation.  (+info)

Molecules containing the 33-kDa plasma protein alpha1-microglobulin were isolated from human plasma by anti-(alpha1-microglobulin) affinity chromatography. Five major bands could be seen after electrophoretic separation of the alpha1-microglobulin-containing proteins under native conditions. Immunoblotting demonstrated alpha1-microglobulin in all five bands. Two of these have been described previously: free alpha1-microglobulin and alpha1-microglobulin complexed with IgA (IgA x alpha1-microglobulin). The other three bands were identified as prothrombin alpha1-microglobulin, albumin x alpha1-microglobulin and dimeric alpha1-microglobulin. Prothrombin x alpha1-microglobulin were 1:2 and 1:1 complexes which carried approximately 1% of total alpha1-microglobulin, had molecular masses of about 145 kDa and 110 kDa upon SDS/PAGE and dissociated completely to free alpha1-microglobulin and prothrombin (72 kDa) when reducing agents were added, suggesting that the complexes were stabilized by disulfide ...
Looking for online definition of Beta-2-microglobulin or what Beta-2-microglobulin stands for? Beta-2-microglobulin is listed in the Worlds largest and most authoritative dictionary database of abbreviations and acronyms
Human β2microglobulin is cytophilic for mouse, rat, and to a lesser extent guinea pig lymphocytes and polymorphonuclear leukocytes but not for human, rabbit, chicken, frog, and turtle cells, nor for any mature erythrocytes tested. Mouse splenic lymphocytes bind 5- 7-fold more β2microglobulin than thymocytes although hydrocortisoneresistant thymocytes resemble spleen cells in this regard. The β2microglobulin binding by B and T cells in mouse spleen is similar. The structure responsible for β2 microglobulin binding to the surface of cells is distinct from the Fc receptor specific for aggregated IgG.. ...
β2-m amyloid fibrils induce apoptosis of HIG-82 cells as measured by the TUNEL assay.After HIG-82 cells were incubated with Hams F12 medium containing vehic
Three capillary dialyzers, with highly permeable membranes, have been compared for their capacity of epuration of blood urea nitrogen, creatinine, phosphorus, uric acid and beta 2 microglobulin, and for their respective protein losses. There were very little differences between the dialyzers for epuration of small uremic molecules, with no benefit due to high permeability membranes in comparison with conventional dialyzers. Protein losses may be important and have to be known. About beta 2 microglobulin, filtered quantities are not correlated to changes in serum levels, suggesting the presence of other mechanisms (adsorption on the membrane and generation during hemodialysis) which influence, together with epuration, perdialytic changes of serum beta 2 microglobulin concentrations.
Objective: To assess the behavior of Beta-2 microglobulin and serum cytokines TNF-α, IFN-γ, IL-2, IL-4 and IL-10 as indicators of highly active antiretroviral therapy (HAART) failure Design: Cross-sectional study. Methods: Eighty-nine HIV-1+ patients and 20 normal individuals were divided into 4 groups: G1- 15 HIV-1+ individuals, previously untreated or without HAART for at least six months and CD4+ , 350 cells/mm3; G2- 31 HIV-1+ individuals undergoing HAART without virological therapeutic failure (TF), G3- 43 HIV-1+ individuals undergoing HAART with TF, and GC- 20 normal individuals who served as controls for serum cytokines. Demographic, clinical and HAART data were reviewed, and Beta-2 microglobulin, serum cytokines (TNF-α, IFN-γ, IL-2, IL-4 and IL-10), HIV-1 genotyping, plasma viral load and CD4+ and CD8+ lymphocytes tests were performed.. Key words: Beta-2 microglobulin, serum cytokines, HIV-1, resistance, HAART, therapeutic failure, genotyping. ...
We analyzed the phenotype and V beta-T cell receptor (TCR) repertoire, together with interleukin 7 receptor (IL-7R) expression in unfractionated thymocytes stimulated in vitro with IL-7. This culture system results in a specific proliferation of mature thymocytes belonging to the CD3+CD4-, CD4+8-, and CD4-8+ subsets. IL-7 induced a preferential expansion of V beta 8.2+CD4-8- and V beta 8.2+CD4-8- thymocytes. This phenomenon is not observed in beta 2-microglobulin-deficient mice, showing that a fraction of CD4+8- thymocytes, enriched in V beta 8.2+ cells, is selected by class I molecules in normal mice, as are a large proportion of CD4-8- alpha beta TCR+ thymocytes. Our findings also establish that IL-7 plays a major role in the expansion of rare thymocyte subsets, which could exert important functions in inflammatory and immune responses. ...
|strong|Mouse anti Human beta 2 microglobulin antibody, clone 2213|/strong| recognizes native human beta 2 microglobulin, a 119 amino acid component of MHC class I molecules present on all nucleated c…
BACKGROUND: In the CALGB (Alliance) 100104 study, lenalidomide versus placebo after autologous stem-cell transplantation (ASCT) was investigated for patients with newly diagnosed myeloma. That study showed improved time to progression and overall survival and an increase in second primary malignancies for lenalidomide at a median follow-up of 34 months. Here we report an updated intention-to-treat analysis of CALGB (Alliance) 100104 at a median follow-up of 91 months.. METHODS: Patients were eligible for this randomised, double-blind, placebo-controlled, phase 3 trial if they had symptomatic disease requiring treatment; had received, at most, two induction regimens; and had achieved stable disease or better in the first 100 days after ASCT. We randomly assigned patients to either lenalidomide or placebo groups using permuted block randomisation, with a fixed block size of six. Randomisation was stratified by three factors: normal or elevated β2 microglobulin concentration at registration ...
Active rheumatoid arthritis and kidney disease can be partially diagnosed with a B2 microglobulin test. Visit RapidTest for kit details. Order online.
Mouse monoclonal Beta 2 Microglobulin Antibody. Tested Applications; Development of assay kits when used in conjunction with clone C21
Mouse Monoclonal beta-2 Microglobulin antibody AA 21-100 for IC, FACS, IHC, ELISA, WB. Order anti-beta-2 Microglobulin antibody ABIN2207569.
To investigate early intermediates of β2-microglobulin (β2m) amyloidogenesis, we solved the structure of β2m containing the amyloidogenic Pro32Gly mutation by X-ray crystallography. One nanobody (Nb24) that efficiently blocks fibril elongation was used as a chaperone to co-crystallize the Pro32Gly β2m monomer under physiological conditions. The complex of P32G β2m with Nb24 reveals a trans peptide bond at position 32 of this amyloidogenic variant, whereas Pro32 adopts the cis conformation in the wild-type monomer, indicating that the cis to trans isomerization at Pro32 plays a critical role in the early onset of β2m amyloid formation.. ...
beta 2 Microglobulin (F21-21), 0.25 mg. Like their mammalian counterparts, avian MHC Class I molecules (also known as B-F antigens) consist of a highly polymorphic alpha-chain (Mr approx.
Gene Information This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains this molecule is localized in the endoplasmic reticulum and Golgi apparatus with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site resulting in a shorter cytoplasmic domain. [provided by RefSeq Jul 2008]. ...
Product Name: Mouse mAb anti- human beta 2 microglobulin (B2MG), Tracer (HRP Labeled), Clone D3A2Collection: AntibodySub Category: Matched Antibody
beta 2 microglobulin - General Practice Notebook, Beta-2 Microglobulin Kidney Disease - Lab Tests Online-UK, Beta-2 Microglobulin - an overview | ScienceDirect Topics, Beta 2-mikroglobulin u krvi i urinu | Kompetentno o , Beta2-Microglobulin: Reference Range, Interpretation
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Beta-2 microglobulin (B2M) is a protein shed by cells into the blood, including tumor cells. The B2M test can be used as a tumor marker for some people with blood cell cancers (multiple myeloma, lymphoma) to give information about their likely prognosis.
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Mouse Monoclonal Anti-alpha 1-Microglobulin Antibody (3F1) [PE]. Validated: WB, ELISA, ICC/IF, IHC, IHC-P. Tested Reactivity: Human. 100% Guaranteed.
Mouse monoclonal Alpha 1 microglobulin antibody [BN11.10] validated for WB, IP, ELISA, IHC, RIA, Other and tested in Human and Rat. Referenced in 1…
β2-MICROGLOBULIN BİOSİSTEM SAĞLIK ÜRÜNLERİ LTD.ŞTİ., İnsan yada farklı veterinerlik uygulamaları için kullanıcı dostu gelişmiş hematoloji sistemleri, kan sayım sistemleri, kan sayım cihazları
Beta-2-microglobulin (B2M), a light chain subunit of the major histocompatibility complex (MHC) class I complex, has been implicated in tumorigenesis. However, whether it is expressed in different epithelial-type ovarian tumours remains unknown. This study was performed to examine the expression of B2M in different histopathological types of ovarian tumours, to explore the function of B2M in ovarian cancer (OC) cells and to investigate the mechanisms underlying the regulation of B2M by the TGF-β signaling pathway. B2M expression in normal ovarian tissues and epithelia-type ovarian tumours was detected by immunohistochemistry and Western blot, followed by the analysis of association with clinical features. OC cells were transfected with B2M-siRNA and cell proliferation, migration and invasion were determined by WST-1 assay, wound healing assay and Transwell invasion assay, respectively. The regulation of B2M by the TGF-β signaling pathway in OC cells was examined by Western blot, ELISA and qRT-PCR. We
Hi, folks, Im trolling this through sci.med in the hopes of picking up some M.D. readers who have hematology experiemce but who dont ordinar- ily read the bionet newsgroups. Similarly for bionet.immunology. How- ever, I have set the followups back to bionet.cellbiol, which I think is the most appropriate newsgroup for this rather technical discussion. Ive run into an interesting problem. I am working with an an- tibody to the class I MHC molecule. I am studying class I MHC in a species of New World Monkey; some individuals react to this antibody, and some of them do not. The antibody recognizes an epitope that spans across the class I heavy chain and beta-2 microglobulin. I have identi- fied an amino acid polymorphism in beta-2m that is responsible for the antibody reactivity. You may recall that class I heavy chains are membrane-anchored molecules, but beta-2m is not. So class I heavy chains can lose their endogenous beta-2m in cell culture, and pick up the beta-2m from the cul- ture medium. ...
As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
Part 1 of this three-part series provides an in-depth look at the history component. By Raemarie Jimenez, CPC, CPC-I, CANPC, CRHC Although evaluation and
Alteration within a discrete region of the H-2Ld alpha 1 helix upon association with human beta 2 microglobulin.: The utilization of the beta 2-microglobulin (B
This website uses cookies to improve your experience while you navigate through the website. Out of these cookies, the cookies that are categorized as necessary are stored on your browser as they are as essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may have an effect on your browsing experience ...
Increased CSF levels, relative to serum levels, are found with CNS involvement in Acute lymphoblastic leukaemia and Lymphoma (non-Hodgkin).. Increased levels are seen with severe neurological impairment in Multiple sclerosis.. ...
Mice hemizygous for the X-linked mutation, scurfy (sf), exhibit a fatal lymphoreticular disease that is mediated by T lymphocytes. To evaluate the respective roles of CD4 or CD8 single positive T cells in scurfy disease, neonates were treated with mAbs directed against the CD4 or CD8 molecules. Whereas mice treated with an anti-CD8 Ab developed lesions and succumbed to disease at the same time (17 days) as their untreated scurfy littermates, mice treated with an anti-CD4 Ab lived up to 11 wk before developing scurfy disease. To insure a more complete elimination of the T cell subsets, the scurfy mutation was bred onto beta 2-microglobulin (beta 2m)-deficient (CD8-less) and CD4-deficient transgenic mouse lines. Whereas there was little moderation of disease in beta 2m-deficient scurfy mice, CD4-deficient scurfy mice had markedly decreased scurfy lesions and a prolonged life span, similar to that of anti-CD4-treated sf/Y mice. Additionally, scurfy disease was transplanted into H-2-compatible nude ...
Answers for What pill is round with a m on one side an a 23 on the other side:A round pill with a 23 on one side and an m on the other is Amlodipine. It is used with or without other medications to treat high blood pressure (hypertension).
First of all I want to thank each and everyone of you ladies for being there for me through my darkest hours. The last 48 hours have been a rollercoaster unlike any other. I went from feeling at my highest thinking I was carrying twins to most likely loosing both. I will keep this a bit short as I am exhausted from these past few days. Not physically but emotionally and mentally exhausted. I went today for the repeat Beta and unfortunately it had gone down to the 700s. My RE and i discussed it and i will continue on my meds until Monday. This way we can feel comfertable that we did not stop the meds too early. Unfortunately, I know in my heart that the Beta will be lower on Monday meaning that I did in fact have a miscarriage of both. My RE is certain that both embabies attached because of the elevated Beta levels. My RE is baffled as we are as we are. With a first Beta of 275 and then a second Beta of 1,513 we were sure that all was progressing. But we were wrong. My RE is not optimistic at ...
The biological assembly is a heterotrimeric complex consisting of one HLA-B*2709 (heavy) chain, one beta-2-microglobulin (light) chain and one decameric model peptide s10R ...
PAA260Hu01, Polyclonal Antibody to Beta-2-Microglobulin (b2M), β2-微球蛋白(b2M)多克隆抗体, BMG; B2MG | 仅供体外研究使用,不用于临床诊断!请索取进口关税税单及报关单!
Vonage Every time I call I m on hold forever. I have to use my cell because my Vonage line doesn t work. Duh that s why I m calling support. Anyway most of the time my battery goes dead because I m on hold for so long. Well folks I solved the problem. I swi
Digestion information covering the digestion system and related diseases, procedures and tests, medications, and treatments. Produced by doctors.
Article Optimising logistic processes with rapidM2M. When delivering products, it is crucial to keep an eye on GPS positions, delivery dates as well as the quality of the products. Machine-to-Machine technology enables you to do so from your office d...
All materials presented on the website have exclusively help and fact-finding character and cannot be considered as the method of treatment appointed by the doctor or sufficient consultation.. Administration of the website and authors of articles do not bear responsibility for any losses and effects which can arise when using materials of the website.. ...
Jefferies & Company reiterated its Buy rating on 3M (NYSE: MMM) but lowered its price target from $110 to $107. Jefferies & Company noted, Given ...
HPI ylpeänä esittelee LEXUS IS200 BTC KORIN touring-autihin! Kirkkaan korin mukana seuraa musta 3D siipisarja. Tämä on aidon HPI:n 2005 sponsoroiman BTTC auton kopio.. Koriin on kopioitu kaikki pienet yksityiskohdat esikuvasta, jotta autostasi tulisi mahdollisimman realistisen näköinen. Korin mukana seuraa viralliset HPI Racing with Friends Reunited -teamin tarrat. 200 mm kori sopii melkein kaikkiin polttomoottorikäyttöisiin touring-autoihin ja moniin 190 mm leveisiin sähkökäyttöisiin touring-autoihin käytettässä vanteita 6 mm offsetillä tai vanteenleventäjiä. ...
Olen NeoLife edasimüüja Eestis üle 20.aasta ja saanud palju häid kogemusi. Minu kõige suurem rõõm on see, et lapselaps on olnud terve ja saanud käia lasteaias. Saavutasime tugeva immuunsuse tänu toitumise parandamisele ja NeoLife toidulisandite tarbimisele. Leia mind FBs ja www.toitumisnoustaja.com ...
Olen NeoLife edasimüüja Eestis üle 20.aasta ja saanud palju häid kogemusi. Minu kõige suurem rõõm on see, et lapselaps on olnud terve ja saanud käia lasteaias. Saavutasime tugeva immuunsuse tänu toitumise parandamisele ja NeoLife toidulisandite tarbimisele. Leia mind FBs ja www.toitumisnoustaja.com ...
Articles M on Peacefulmind.com | Its important that you develop effective strategies for managing your time to balance the conflicting demands of time for…
TY - JOUR. T1 - Interferons up-regulate with different potency HLA class I antigen expression in M14 human melanoma cell line. Possible interaction with glucocorticoid hormones. AU - Lanza, Lorella. AU - Peirano, Lorenza. AU - Bosco, Ornella. AU - Contini, Paola. AU - Filaci, Gilberto. AU - Setti, Maurizio. AU - Puppo, Francesco. AU - Indiveri, Francesco. AU - Scudeletti, Marco. PY - 1995/1. Y1 - 1995/1. N2 - The relative potency of interferon α (IFNα), interferon β (IFNβ), and interferon γ (IFNγ) in inducing the expression of HLA class I antigens, as well as their capacity to counteract the inhibition induced by glucocorticoid hormones on HLA class I antigen expression, were analysed in the human melanoma cell line M14, both at membrane and at mRNA level. The data obtained indicate that (a) IFN enhance with different potency (IFNγ,IFNβ,IFNα) the expression of HLA class I antigens in M14 cells, (b) prednisone inhibits HLA class I antigen expresion, (c) glucocorticoid hormones, when ...
TY - JOUR. T1 - Persistent fever and destructive arthritis caused by dialysis-related amyloidosis. AU - Matsumoto, Kotaro. AU - Kikuchi, Jun. AU - Kaneko, Yuko. AU - Yasuoka, Hidekata. AU - Suzuki, Kazuko. AU - Tokuyama, Hirobumi. AU - Kameyama, Kaori. AU - Yamaoka, Kunihiro. AU - Takeuchi, Tsutomu. PY - 2018/1/1. Y1 - 2018/1/1. N2 - Rationale: Dialysis-related amyloidosis (DRA) can present rheumatic manifestations in patients on long-term hemodialysis. Typical articular symptoms with DRA involve carpal-tunnel syndrome, effusion in large joints, spondyloarthropathy, or cystic bone lesions, which are usually with non-inflammatory processes. Patient concerns: A 64-year-old man on hemodialysis for ,30 years was admitted because of intermittent fever, polyarthritis, and elevated serum C-reactive protein (CRP) level, which was continuous for 2 years. Several antibiotics were ineffective for 3 months before his admission. On physical examination, joint swelling was observed at bilateral wrists, knees, ...
Protein aggregation is the cause of several human diseases such as diabetes mellitus type 2, Parkinson s disease, Alzheimer s disease, Huntington s disease, spongiform encephalopathies, congestive heart failure or dialysis-related amyloidosis. All of these disorders result from protein misfolding which leads to fibrillization and deposition of amyloid plaques in different parts of the body.Due to high molecular weight of the amyloid fibrils and intrinsic heterogeneity of the intermediate states, protein aggregation is a very challenging field of study for the structural biologist. However, nuclear magnetic resonance (NMR) provides a unique possibility to investigate aggregation at all stages, from the monomer to the fibrils.In this work, structural changes involved in prion diseases and dialysis-related amyloidosis are investigated with the help of various NMR techniques.Prion diseases are caused by the aggregation of the natively α-helical prion protein PrPC into its pathological β-sheet-rich ...
Long-term dialysis treatment is tough on the body in many ways, but one of the most serious complications is dialysis-related amyloidosis, a disease characterized by abnormal buildup of protein aggregates-called amyloid fibrils-in joints, tissues and organs.. Although there is no cure, recent research by Osaka University researchers sheds light on how amyloid fibrils form and aggregate, thereby allowing the identification of new therapeutic and preventive avenues to further improve the lives of sufferers.. In a study published in Proceedings of the National Academy of Sciences, Osaka University researchers have identified that polyphosphate (polyP), which is a naturally occurring polymer in the body and a food and drink additive, induces the formation of amyloid fibrils from β2 microglobulin proteins.. PolyPs play an important role in life as storage of phosphorous. When kidney function is normal, β2 microglobulin serum blood levels remain low. However, β2 microglobulin are not efficiently ...
Looking for online definition of beta2 microglobulin in the Medical Dictionary? beta2 microglobulin explanation free. What is beta2 microglobulin? Meaning of beta2 microglobulin medical term. What does beta2 microglobulin mean?
Mhc class I molecules display intracellularly derived peptides on the surface of almost all nucleated mammalian cells for recognition by the immune system. MHC class I heavy chain, which contains the peptide binding site, is a classical type I transmembrane protein with a large luminal/extracellular domain and a short cytosolic tail. The heavy chain enters the secretory pathway via the ER translocon, a channel whose major component is Sec61. The light chain β2 microglobulin (β2m)1 and the peptide associate with the heavy chain after it has been inserted into the ER membrane, and the complex is then transported, via the Golgi, to the plasma membrane. In humans, the MHC class I heavy chain is a 43-kD protein that contains a single N-linked glycan.. Human cytomegalovirus (HCMV) evades detection by the immune system by targeting MHC class I heavy chains for destruction soon after they have been synthesized. The HCMV proteins responsible for MHC class I heavy chain destruction are US11 and US2 ...
Misfolding and aggregation of normally soluble proteins into amyloid fibrils and their deposition and accumulation underlies a variety of clinically significant diseases. Fibrillar aggregates with amyloid-like properties can also be generated in vitro from pure proteins and peptides, including those not known to be associated with amyloidosis. Whereas biophysical studies of amyloid-like fibrils formed in vitro have provided important insights into the molecular mechanisms of amyloid generation and the structural properties of the fibrils formed, amyloidogenic proteins are typically exposed to mild or more extreme denaturing conditions to induce rapid fibril formation in vitro. Whether the structure of the resulting assemblies is representative of their natural in vivo counterparts, thus, remains a fundamental unresolved issue. Here we show using Fourier transform infrared spectroscopy that amyloid-like fibrils formed in vitro from natively folded or unfolded β2-microglobulin (the protein ...
Sera and questionnaire data from a population-based random sample of healthy adults was used to evaluate factors influencing neopterin and beta 2-microglobulin (beta 2m) values. Both neopterin and beta 2m levels increased with age and were higher among white than blacks (mean values for whites and blacks: neopterin, 5.06 vs 4.49 nmol/L; beta 2m, 1.36 vs 1.28 mg/L). Gender
Serial determinations of beta 2-microglobulin, lactoferrin and lysozyme in CSF were performed in 14 patients with acute cerebrovascular lesions. Marked elevations were noted in patients with cerebral bleeding or hemorrhagic infarction. Patients with infarction without signs of bleeding or with cerebrovascular lesions undetectable by computed tomography also had an increase in these proteins. The increases in CSF of beta 2-microglobulin, lactoferrin and lysozyme could not be explained by a damaged blood-brain barrier but was believed to be a local product of the central nervous system. Peak levels of lactoferrin and lysozyme were noted on day 2-3 after onset of symptoms. Lactoferrin then declined while lysozyme remained elevated for another few days. beta 2-microglobulin gradually increased reaching peak levels on day 4-5 and remained elevated even 2 weeks after the onset of symptoms. We suggest that the increases of lactoferrin, lysozyme and beta 2-microglobulin reflect various inflammatory ...
TY - JOUR. T1 - Genome-wide association study identified the human leukocyte antigen region as a novel locus for plasma beta-2 microglobulin. AU - Tin, Adrienne. AU - Astor, Brad C.. AU - Boerwinkle, Eric. AU - Hoogeveen, Ron C.. AU - Coresh, Josef. AU - Kao, Wen Hong Linda. PY - 2013/6. Y1 - 2013/6. N2 - Beta-2 microglobulin (B2M) is a component of the major histocompatibility complex (MHC) class I molecule and has been studied as a biomarker of kidney function, cardiovascular diseases and mortality. Little is known about the genes influencing its levels directly or through glomerular filtration rate (GFR). We conducted a genome-wide association study of plasma B2M levels in 6738 European Americans from the Atherosclerosis Risk in Communities study to identify novel loci for B2M and assessed its association with known estimated GFR (eGFR) loci. We identified 2 genome-wide significant loci. One was in the human leukocyte antigen (HLA) region on chromosome 6 (lowest p value = 1.8 × 10 -23 for ...
Normal kidneys filter and remove excess small proteins from the blood, thus keeping blood levels normal. When the kidneys dont work properly, as in patients receiving dialysis, one type of small protein calle beta-2-microglobulin builds up in the blood. When this occurs, beta-2-microglobulin molecules may join together, like the links of a chain, forming a few very large molecules from many smaller ones. These large molecules can form deposits and eventually damage the surrounding tissues and cause great discomfort. This condition is called dialysis-related amyloidosis (DRA). DRA is relatively common in patients, especially older adults, who have been on hemodialysis for more than 5 years. Hemodialysis membranes that have been used for many years dont effectively remove the large, complex beta-2-microglobulin proteins from the bloodstream. Newer hemodialysis membranes, as well as peritoneal dialysis, remove beta-2-microglobulin more effectively, but not enough to keep blood levels normal. As a ...
A multi-institutional trials program was initiated to define the effects of interferons in disseminated human breast carcinoma. Interferon alpha, prepared from buffy coats, was administered intramuscularly at 3 ×106 U daily for an initial period of 28 days. Of 23 patients who entered the program, five had an objective partial response of 92 days mean duration at diverse sites of involvement. Patients who responded were significantly older (p = 0.05) than nonresponders. Dose escalation in eight patients did not result in any clear evidence of additional responses. Major toxicities were fatigue, anorexia with weight loss, and reversible leukopenia (less than 3.5 ×109 leukocytes/L in 16 patients). Natural killer cell and antibody-dependent cell-mediated cytotoxicity were significantly (p , 0.05) enhanced 48 hours after interferon administration began but subsequently declined despite continued therapy. Serum β2microglobulin concentration increased on day 15 (p , 0.05) and remained significantly ...
Overview: Immunopathogenesis of sepsis, innate immunity Research Interests. We demonstrated that ß2 microglobulin knockout mice that are depleted of natural killer (NK) cells by treatment with anti-asialoGM1 exhibit decreased systemic inflammation, less metabolic acidosis, reduced hypothermia, better hemodynamic function and improved survival compared to control mice following cecal ligation and puncture (CLP). ß2MKO/aAsGM1 mice have multiple immunological defects including an absence of CD8+ T, natural killer (NK) and natural killer T (NKT) cells as well as deficient expression of the class I major histocompatability complex (MHC-I) and CD1 molecules. Our recent ?ndings strongly support the contention that depletion of CD8+ T and NK cells are the primary factors providing protection from CLP-induced injury in ß2MKO/aAsGM1 mice. Most recently, we have focused on the contributions of NK cells to the pathogenesis of septic shock caused by cecal ligation and puncture. Our recent studies ...
Principal Investigator:MARUYAMA Hiroki, Project Period (FY):1998 - 2000, Research Category:Grant-in-Aid for Scientific Research (C), Section:一般, Research Field:Kidney internal medicine
DRA stands for dialysis-related amyloidosis. This form of amyloidosis is prominent in older adults. This is due to the fact that the prominent cause of DRA is dialysis for five years or more. Various studies have shown a direct correlation between long-term dialysis and the development of this type of amyloidosis. In this form of amyloidosis, beta-2 microglobulin deposits start to build up in the blood due to the dialysis.. The buildup happens at a relatively slow pace, but it eventually gets to the point where symptoms will develop. Most doctors believe that the beta-2 microglobulin buildup begins immediately starting from when the dialysis is initiated but remains asymptomatic until the fifth year or beyond.. Some patients have even experienced symptoms of DRA sooner than five years, but it remains the average after analyzing a large number of cases. Patients relying on dialysis should be on the lookout for this form of amyloidosis.. ...
Approval for the lixelle® ß2-microglobulin apheresis column (also called the beta2-microglobulin apheresis column or ß2m). This device is indicated for the treatment of patients with clinically diagnosed dialysis-related amyloidosis (dra ...
Correlation of Beta-2 Microglobulin with serum creatinine and creatinine clearance in patients with different levels of renal function
RefSeq Summary (NM_002116): HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq, Jul 2008 ...
RefSeq Summary (NM_002116): HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq, Jul 2008 ...
Bortezomib-melphalan-prednisone (VMP) showed superior efficacy versus MP as first-line treatment for transplantation-ineligible multiple myeloma (MM). This study investigated the efficacy of VMP for Korean patients with MM. Overall, 177 MM patients received 9 cycles of VMP in this prospective, multicenter, observational study. The primary endpoint was 2-year progression-free survival (PFS). Thirty-nine (22%) patients were aged >= 75 years and 83 (47.4%) patients had International Staging System stage III. A median of 5 cycles were delivered. Overall response rate (ORR) was 72.9%, and complete response (CR) rate was 20.3%. With a median follow-up of 11.9 months, median PFS was 17 months. The 2-year PFS and overall survival (OS) rates were 29.2% and 80.0%, respectively. Median OS was not reached. PFS was significantly different depending on performance status (Eastern Cooperative Oncology Group < 2 vs. >= 2; p = 0.0002), beta(2)-microglobulin level (< 5.5 vs. = 5.5 mg/L; p = 0.0481), and ...
Measurement of urinary beta core fragment of human chorionic gonadotrophin in women with vulvovaginal malignancy and its prognostic significance
Small Round Blue Pill With M On One Side And H25 The Other - Topics (Showing results 1 - 6 of 6)... round blue pill with m on one side and 15 other: Small blue round pill. M on one side,H25 on the other. Can you identify for me please? ## The tablet... h25 on one side m the other very small round blue pill: I wondered
1I1F: The structural basis for the increased immunogenicity of two HIV-reverse transcriptase peptide variant/class I major histocompatibility complexes.
A new low molecular weight protein was purified from the urine of uraemic patients. The protein was found to be glycoprotein with a molecular weight of 31 500, determined by SDS-polyacrylamide gel electrophoresis, and a carbohydrate content of 19%. It was electrophoretically heterogenous and migrate …
The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed ...
Sekisui Diagnostics has a broad product portfolio to meet your diagnostics needs. Systems, reagents, tests, enzymes and specialty biochemicals. Quality products for laboratory and research environments.
Affiliation:Fujita Health Univ.,Sch.of Medicine,Assistant,医学部,助手, Research Field:Digestive surgery, Keywords:Lymphokine activated killer,Beta 2 microgobulin,Cancer metastasis,Interleukin-2,beta_2 microglobulin,胸管リンパ球,高速度ビデオ,組織適合抗原,養子免疫療法,Major histocompatibility complex, # of Research Projects:2, # of Research Products:0
A select number of offers are issued in December and are based on a combination of Grade 11 and Grade 12 results. To be eligible for an early offer you must have 1.0 final Grade 12 result at the 4U or 4M-level, and five Grade 11 U or M-level credits. Averages are in the high 80s or 90s. The first major round of admission offers to Ontario applicants is in February. Admission averages are calculated using a minimum 3.0 first-semester Grade 12 4U or 4M finals, with registration in 3.0 additional 4U or 4M credits, including prerequisites. If you are in a non-semester school, we will use 6.0 mid-term grades at the Grade 12 4U or 4M level, including prerequisites. The final round of admission offers happens in May. If you do not receive an offer in February, or if you are still in studies and received an alternate program offer, we will automatically reassess you for eligibility for your preferred program in May. We will continue to make offers based on final grades, as well as summer school grades ...
Billing E&M level with mod 25 and procedure 97597; no wound closure, just a dressing application. Medicare is paying the E&M but not processin
Stomach. (a) The expression of PPARα, β, and γ mRNA is shown across the fetal age range. Log plot of mean ± SEM Ct is normalized to β-2-microglobulin (B2M
We have an innate mechanism that ensures that our blood vessels do not become blocked. The protein A1M, alpha-1-microglobulin, is naturally present in the body and prevents oxidation of blood fats-a major cause of atherosclerosis. The discovery is the work of a research group led by Bo Åkerström of Lund University, Sweden.. ...
We are pleased to announce that effective July 8, 2011, the Continuous Suspended Particulate Beta Attenuation Analyzer MP101M with associated module CPM has ...
Salesforce has undertaken a significant commitment to equality, according to APAC CMO Wendy Johnstone, putting its money where its mouth is on the gender wage gap.
Another day, another new chapter added to the ongoing Johnny Manziel saga. ESPN reported on Tuesday that an autograph broker paid the Texas A&M quarterback $7,500 for 300 ...
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Retrieved from http://www.telegraph.co.uk/news/worldnews/asia/southkorea/7376178/Korean-couple-let-baby-starve-to-death-while-caring-for-virtual-child. ...
Thanks for your explanation Moritz. I meant $1 value got changed similar to $_ value for better understanding. I know that $_ value getting changed due to substitute operator replaces matched digits to null string. I have a doubt in your example, how $1 value getting changed every recursive call. As per your code, your m// expression will match first digits ( 55 ) at all time as per my understanding. Of course, when I checked the code, it gives $1 value as 55, 666, 7777 and 1 respectively. Kindly give me some detail about it ...
Etizola Beta is a medicine available in a number of countries worldwide. A list of US medications equivalent to Etizola Beta is available on the Drugs.com website.
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Difference between v2.9.0.0 and the previous beta (Page 1) - Forex Strategies - Forex Forum - Testing and Trading Forex Strategies
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Dano is a leaked beta version of the Be Operating System (BeOS). It is more properly called Exp/Dano, or 5.1d0. This was the last stage in the official...
Beta-2-microglobulin regulator is a protein in humans that is encoded by the B2MR gene. "Entrez Gene: Beta-2-microglobulin ...
"Skin graft rejection by beta 2-microglobulin-deficient mice". The Journal of Experimental Medicine. 175 (4): 885-93. doi: ... 66 (2): 189-203. doi:10.1016/s0016-5085(74)80102-2. PMID 4810912. Onori P, Franchitto A, Sferra R, Vetuschi A, Gaudio E (May ...
... higher levels of serum lactate dehydrogenase and Beta-2 microglobulin; and c) lower rates of bone but higher rates of soft ... It is the terminal stage and most aggressive form of these dyscrasias, constituting 2% to 4% of all cases of plasma cell ... median survival rates from the time of diagnosis for pPCL and sPCL were 8-11 months and 2-8 months, respectively, even when ...
The urinary beta-2 microglobulin test is an indirect method of measuring cadmium exposure. Under some circumstances, the ... Increased concentrations of urinary beta-2 microglobulin can be an early indicator of kidney dysfunction in persons chronically ... 2 (3): 215-229. doi:10.1007/BF03353912. hdl:2115/53361. ISSN 1867-383X. S2CID 1902243. (IARC)International Agency for Research ... 208 (1-2): 123-6. Bibcode:1997ScTEn.208..123T. doi:10.1016/S0048-9697(97)00273-8. PMID 9496656. Boparei. (2010). Kinetics and ...
... alpha/beta T cells demonstrates preferential use of several V beta genes and an invariant TCR alpha chain". Journal of ... Like MHC class I, MR1 is found in all a large variety of cells and associates with β2-microglobulin. However, it remains to be ... with beta(2)-microglobulin". Biochemical and Biophysical Research Communications. 290 (2): 722-729. doi:10.1006/bbrc.2001.6277 ... The TCRα originates from the rearrangement of TCRα variable (V) and joining (J) gene segments TRAV1-2/TRAJ12/20/33 during VDJ ...
Estrogen receptor beta gene (ESR2) seems to be a key to pathogenesis and response to therapy. Other genes that have been ... In addition, the cancer markers used vary with tumor type: choriocarcinomas are monitored with beta-HCG and endodermal sinus ... The OVA1 panel includes CA-125, beta-2 microglobulin, transferrin, apolipoprotein A1, and transthyretin. OVA1 above 5.0 in ... People with hereditary nonpolyposis colon cancer (Lynch syndrome), and those with BRCA-1 and BRCA-2 genetic abnormalities are ...
Together with β2-microglobulin (β2m), MHC-I heavy chains form assemblies of heterodimers that act as receptors for antigenic ... Ortmann B, Androlewicz MJ, Cresswell P (April 1994). "MHC class I/beta 2-microglobulin complexes associate with TAP ... In addition to this, β2-microglobulin (β2m) is attached to the heavy chains of the heterodimers and as a whole they act as ... heavy chain and β2 microglobulin). The use of a photo-cleavable high-affinity peptide allowed researchers to form a stable ( ...
September 1993). "beta 2-Microglobulin modified with advanced glycation end products is a major component of hemodialysis- ... Long-term haemodialysis results in a gradual accumulation of β2 microglobulin, a serum protein, in the blood. It accumulates ... Use of high flux dialyzers Use of Beta 2 globulin absorber Preserve the residual kidney functions Early kidney transplant In ... Destructive spondylarthropathy with b2-microglobulin deposits in a uremic patient before chronic hemodialysis. Nephron 1991; 59 ...
Because beta-2-microglobulin is a large molecule, with a molecular weight of about 11,600 daltons, it does not pass at all ... Beta-2-M is removed with high-flux dialysis, but is removed even more efficiently with IHDF. After several years (usually at ... The goal of high-flux membranes is to pass relatively large molecules such as beta-2-microglobulin (MW 11,600 daltons), but not ... Beta-2-M amyloidosis can cause very serious complications, including spondyloarthropathy, and often is associated with shoulder ...
It is an Fc receptor which is similar in structure to the MHC class I molecule and also associates with beta-2-microglobulin. ... Microglobulin is important for cell surface expression and pH-dependent IgG binding of human FcRn". J. Cell Sci. 115 (Pt 11): ... "Functional reconstitution of human FcRn in Madin-Darby canine kidney cells requires co-expressed human beta 2-microglobulin". J ... 321 (2): 277-84. doi:10.1016/S0022-2836(02)00626-5. PMID 12144784. Shah U, Dickinson BL, Blumberg RS, Simister NE, Lencer WI, ...
Furthermore, Durie showed it was possible to stratify myeloma patients based on combinations of serum beta 2 microglobulin with ... His research concluded that serum beta 2 microglobulin is the most powerful prognostic factor currently available for multiple ... 3.0.co;2-u "A clinical staging system for multiple myeloma correlation of measured myeloma cell mass with presenting clinical ... 3.0.co;2-u. ISSN 0008-543X. Durie, B.; Salmon, S. (1975-12-12). "High speed scintillation autoradiography". Science. 190 (4219 ...
They use an MHC class I molecule coupled to beta-2 microglobulin to display endogenous peptides on the cell membrane. These ... 162 (2 Pt B): 103-12. doi:10.1016/j.imlet.2014.10.011. PMID 25455596. Hivroz C, Chemin K, Tourret M, Bohineust A (2012). " ... 32 (2): 139-55. doi:10.1615/critrevimmunol.v32.i2.30. PMID 23216612. Barral DC, Brenner MB (December 2007). "CD1 antigen ...
MHC class I contains Beta-2 microglobulin. The short cytoplasmic/intracellular tail (C) of CD4 contains a special sequence of ... 2 (2): 141-51. doi:10.2174/1570162043484924. PMID 15078178.. *. Hout DR, Mulcahy ER, Pacyniak E, Gomez LM, Gomez ML, Stephens ... D2 and D4 resemble immunoglobulin constant (IgC) domains.. The immunoglobulin variable (IgV) domain of D1 adopts an ... 2 (3): 255-70. doi:10.2174/1570162043351246. PMID 15279589.. *. Joseph AM, Kumar M, Mitra D (January 2005). "Nef: "necessary ...
A mouse model with deregulation of beta-catenin levels was created. The conditional stabilizing mutation in the beta-catenin ... there was substantial nuclear localization of beta-catenin as well as increased cytoplasmic beta-catenin. However, in mice fed ... Furthermore, when evaluated for ERCC1, beclin-1, and beta-catenin in the stem cell region of crypts, the colonic tissues of ... Today we know that the beta-catenin protein (part of the Wnt signaling pathway) is implicated in colorectal carcinogenesis and ...
Beta 2-microglobulin-, CD8+ T-cell-deficient mice survive inoculation with high doses of vaccinia virus and exhibit altered IgG ... beta2-Microglobulin dependence of the lupus-like autoimmune syndrome of MRL-lpr mice. J. Immunol. 156: 4932-4939. Junghans, R. ... Requirement for a b2-microglobulin-associated Fc receptor for acquisition of maternal IgG by fetal and neonatal mice. J. ... The protection receptor for IgG catabolism is the b2- microglobulin-containing neonatal intestinal transport receptor. Proc. ...
By studying them, we can discover some of the essential features that enable transmembrane beta-barrel proteins to fold into a ... Sheena's work on dialysis-dependent amyloidosis has shown that protein unfolding of beta-2-microglobulin is a key step in ... These proteins share a similar nanoscale structure, a transmembrane beta-barrel, through which other molecules can pass. ... Archived from the original on 2 May 2014. CS1 maint: discouraged parameter (link) Anon (2010). "Professor Sheena Radford FRS ...
Brodsky, F. M.; Bodmer, W. F.; Parham, P. (1979). "Characterization of a monoclonal anti-beta 2-microglobulin antibody and its ... 53 (2): 129-139. doi:10.1016/S0198-8859(97)00001-3. ISSN 0198-8859. PMID 9129970. Liu, S. H.; Wong, M. L.; Craik, C. S.; ... 83 (2): 257-267. doi:10.1016/0092-8674(95)90167-1. ISSN 0092-8674. PMID 7585943. Stoddart, Angela; Dykstra, Michelle L.; Brown ...
Class I MHC molecules are made up of a polymorphic heavy α-chain associated with an invariant light chain beta-2 microglobulin ...
Only the α chain is polymorphic and encoded by a HLA gene, while the B2M subunit is not polymorphic and encoded by the Beta-2 ... MHC class I molecules are heterodimers that consist of two polypeptide chains, α and β2-microglobulin (B2M). The two chains are ... microglobulin gene. The α3 domain is plasma membrane-spanning and interacts with the CD8 co-receptor of T-cells. The α3-CD8 ... 110 (2): 163-9. doi:10.1046/j.1365-2567.2003.01738.x. PMC 1783040. PMID 14511229. Kulski JK, Shiina T, Anzai T, Kohara S, Inoko ...
Santos, M., Schilham, MW, Rademakers, LHPM, Marx, JJM, de Sousa, M. and Clevers, H. "Defective iron homeostasis in beta 2- ... S. "Iron overload in ß2 microglobulin deficient mice". Immunol. Lett. 39: 105-111. 1994. ... microglobulin knockout mice recapitulates Hereditary Hemochromatosis in man". J.Exp.Med, 184: 1975-1985. 1996. De Almeida SF, ... Minder, Raphael (2 July 2020). "Maria de Sousa, Leading Portuguese Scientist, Dies at 80". The New York Times. Retrieved 5 ...
Human T-cell leukemia virus type-1 Protein TAX-1 (TAX) and Beta-2-microglobulin (B2M) were found to interact with TMEM239 ... 206 (2-3): 223-31. doi:10.1016/j.psychres.2012.11.002. PMID 23218918. S2CID 22967553. Maretti-Mira AC, Bittner J, Oliveira-Neto ... 2 retroviruses". Retrovirology. 9 (1): 26. doi:10.1186/1742-4690-9-26. PMC 3351729. PMID 22458338. "SDCBP - Syntenin-1 - Homo ... RhoGEF and PH domain-containing protein 2 (FGD2) and Syndecan binding protein (SDCBP). The Golgi SNAP receptor complex member 1 ...
Praetor A, Hunziker W (2002). "beta(2)-Microglobulin is important for cell surface expression and pH-dependent IgG binding of ... "Functional reconstitution of human FcRn in Madin-Darby canine kidney cells requires co-expressed human beta 2-microglobulin". J ... 321 (2): 277-84. doi:10.1016/S0022-2836(02)00626-5. PMID 12144784. Shah U, Dickinson BL, Blumberg RS, Simister NE, Lencer WI, ... 73 (1-2): 97-8. doi:10.1159/000134316. PMID 8646894. "Entrez Gene: FCGRT Fc fragment of IgG, receptor, transporter, alpha". ...
... beta-crystallin a chain MeSH D12.776.306.366.300.200 - beta-crystallin b chain MeSH D12.776.331.199.750.500 - succinate ... thyroid hormone receptors beta MeSH D12.776.624.664.700.915 - RNA-binding protein FUS MeSH D12.776.624.664.700.957 - stathmin ... Retinoid X receptor beta MeSH D12.776.826.701.500.750 - Retinoid X receptor gamma MeSH D12.776.826.750.074.249 - coup ... transforming growth factor beta MeSH D12.776.467.374.440.890 - interferon type i MeSH D12.776.467.374.440.890.125 - interferon ...
... beta-thromboglobulin MeSH D12.776.124.790.223.200 - complement factor h MeSH D12.776.124.790.223.338 - hemopexin MeSH D12.776. ... pregnancy-associated alpha 2-macroglobulins The list continues at List of MeSH codes (D12.776.157).. ...
Increased LDH is seen in approximately 75%, but unlike other large cell lymphomas, no increase in beta-2 microglobulin is seen ... 2 (4th ed.). International Agency for Research on Cancer. ISBN 9789283224310. Jaffe, ES; Harris NL; Vardiman JW; Campo E; Arber ... 7 (2): 125-33. PMID 19367254. Dabrowska-Iwanicka A, Walewski JA (2014). "Primary mediastinal large B-cell lymphoma". Curr ... 8 (2): 173-86. doi:10.1586/17474086.2015.994604. hdl:11573/780924. PMID 25537750. S2CID 23040185. Sweetenham, J. Lymphomas ( ...
... peptides are loaded onto MHC class I molecules with the help of the peptide loading complex and chaperone proteins such as beta ... 1 (2): 126-34. doi:10.1038/35100512. PMID 11905820. Rock, KL (1996). "A new foreign policy: MHC class I molecules monitor the ... 1 (2): 126-134. doi:10.1038/35100512. ISSN 1474-1741. PMID 11905820. Huang, AY; Golumbek, P; Ahmadzadeh, M; Jaffee, E; Pardoll ... Bevan, MJ (1976). "Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not ...
... a South Korean music label Beta-2 microglobulin, a gene or protein Boyz 2 Men American R&B music group Business to many, ...
Alpha-1-acid glycoprotein Alpha-1-fetoprotein alpha2-macroglobulin Gamma globulins Beta-2 microglobulin Haptoglobin ... 2 (3): 185-95. doi:10.1016/j.cels.2016.02.015. PMID 27135364. Clinical Chemistry : a laboratory perspective / [edited by] Wendy ... 565-594, doi:10.1016/b978-0-12-415759-0.00018-2, ISBN 978-0-12-415759-0, retrieved 2020-11-16 Anderson NL, Anderson NG (1977 ...
... beta 1a Interferon beta 1b Interferon gamma Interferon type I Interferon type II Interferon type III Interferon-alpha/beta ... beta subunit Interleukin 12 Interleukin 12 subunit beta Interleukin 13 Interleukin 16 Interleukin 2 Interleukin 20 receptor, ... antigen 1 Lymphokine Lymphoproliferative response Lymphotoxin Lymphotoxin alpha Lymphotoxin beta Lymphotoxin beta receptor ... beta Interleukin receptor Interleukin-1 receptor Interleukin-1 receptor family Interleukin-1 receptor-associated kinase ...
It can be contrasted to macroglobulin., Examples include: Beta-2 microglobulin Alpha-1-microglobulin "Definition: microglobulin ... Microglobulin is a globulin of relatively small molecular weight. ...
... beta-2 microglobulin (β2M) - bilirubin - bioavailability - biological response modifiers (BRMs) - biopsy - biotechnology - ... HIV-2) - human leukocyte antigens (HLA) - human papilloma virus (HPV) - human T cell lymphotropic virus type I (HTLV-I) - human ... herpes simplex virus 2 (HSV-2) - herpes varicella zoster virus (VZV) - herpes viruses - highly active antiretroviral therapy ( ... HIV-2 - HIV-associated dementia - HIV-related tuberculosis - HLA - Hodgkin's disease - holistic medicine - homology (biology) ...
The protein is composed of alpha helices and beta sheets that form two domains.[8] The N- and C- terminal sequences are ... 283 (2): 611-5. doi:10.1042/bj2830611. PMC 1131079. PMID 1315521.. *^ M Ching-Ming Chung (October 1984). "Structure and ... Transferrin has been shown to interact with insulin-like growth factor 2[18] and IGFBP3.[19] Transcriptional regulation of ... For the iron ion to bind, an anion is required, preferably carbonate (CO2−. 3).[8] ...
They have a characteristic immunoglobulin fold in which two beta sheets create a "sandwich" shape, held together by ... 67 (2): 95-106. doi:10.1016/j.molimm.2015.01.003.. *^ a b Farlex dictionary , polyvalent Citing: The American Heritage Medical ... 2): 37-42. doi:10.1159/000055400. PMID 11694786.. *^ LeBien TW (1 July 2000). "Fates of human B-cell precursors". Blood. 96 (1 ... 2 (e456). doi:10.7717/peerj.456. PMC 4103072 . PMID 25071986.. *^ Heyman B (1996). "Complement and Fc-receptors in regulation ...
MHC class I proteins associate with β2-microglobulin, which unlike the HLA proteins is encoded by a gene on chromosome 15. ... beta-sheet 1), functional information (e.g., peptide antigen-binding), and polymorphism. These sequence features can be ... 17 (2): 179-224. PMID 9094452. doi:10.1615/critrevimmunol.v17.i2.40.. .. *^ Wedekind C, Seebeck T, Bettens F, Paepke AJ (June ... 2.2.2 Sequence feature variant type (SFVT). *2.2.3 Common, well-documented and rare alleles *2.2.3.1 Table of HLA alleles in ...
Macroglobulin/Microglobulin. *Transcobalamin. *Edestin. Other globulins. *Beta-lactoglobulin *Lactoferrin. *Thyroglobulin. * ... 397 (2): 345-53. doi:10.1042/BJ20051863. PMC 1513275 . PMID 16608438.. *^ "Hemp Repairs Damaged DNA". High Times. 28 Aug 2014. ... Albumin comprises three homologous domains that assemble to form a heart-shaped protein.[2] Each domain is a product of two ... subdomains that possess common structural motifs.[2] The principal regions of ligand binding to human serum albumin are located ...
Beta-lactoglobulin. References[edit]. 1. Influence Of Dietary Lactalbumin Hydrolysate On The Immune System Of Mice And ... There are alpha and beta lactalbumins; both are contained in milk.. Scientific studies suggest that certain types of ... 2. Influence Of Dietary Proteins On The Immune System Of Mice Bounous G., Kongshavn P.A. J Nutr.Sep; 112(9) :1747-55 (1982) ... 2, 395-402, 2008.. Oxidative stress plays a role in the tumor-cytotoxic effect of cancer chemotherapy and radiotherapy and also ...
CD8-positive, alpha-beta T cell differentiation involved in immune response. • neutrophil apoptotic process. • sensory ... as well as TAP and ERAAP in addition possibly to the direct upregulation of MHC heavy chains and B2-microglobulin itself ... positive regulation of amyloid-beta formation. • negative regulation of tau-protein kinase activity. • positive regulation of ... negative regulation of amyloid-beta clearance. • positive regulation of neuron death. • positive regulation of cellular ...
alpha/beta (αβ) T cells: Their TCR is a heterodimer of an alpha chain with a beta chain. Each chain has a variable (V) region ... β2 microglobulin. The partially folded MHC class I molecule then interacts with TAP via tapasin (the complete complex also ... The discussion that follows now concerns alpha/beta T cells. The TCR (of αβ T-cells) binds a bimolecular complex displayed at ... 1 (2): 126-134. doi:10.1038/35100512. PMID 11905820.. *^ Deretic, V., & Fratti, R. A. (1999). Mycobacterium tuberculosis ...
β乳球蛋白(英語:Beta-lactoglobulin)(乳鐵蛋白) · 甲狀腺球蛋白 · α乳清蛋白 ... 巨球蛋白(英語:Macroglobulin)/微球蛋白(英語:Microglobulin) ... 抗體(antibody),又稱免疫球蛋白(immunoglobulin,簡稱Ig)[1],是一種主要由漿細胞分泌,被免疫系統用來鑑
Macroglobulin/Microglobulin. *Transcobalamin. *Edestin. Other globulins. *Beta-lactoglobulin *Lactoferrin. *Thyroglobulin. * ... 2][3] Aging causes a small decrease in plasma albumin levels; if anything, there is a small increase in alpha-1-acid ... 2] Plasma levels are affected by pregnancy, burns, certain drugs, and certain diseases, particularly HIV.[2] ... 11 (2): e1001606. doi:10.1371/journal.pmed.1001606. PMC 3934819. PMID 24586121.. ...
... beta-2 microglobulin, arginine vasopressin and nitric oxide into CSF.[3] A Na-K-Cl cotransporter and Na/K ATPase found on the ... a beta-2 transferrin test of the leaking fluid, when positive, is highly specific and sensitive for the detection for CSF ... Most (about two-thirds to 80%) of CSF is produced by the choroid plexus.[1][2] The choroid plexus is a network of blood vessels ... CSF pressure, as measured by lumbar puncture, is 10-18 cmH2O (8-15 mmHg or 1.1-2 kPa) with the patient lying on the side and 20 ...
The proportions are 78% beta-hydroxybutyric acid, 20% acetoacetic acid and 2% acetone. The test used in the urine test strips ... Other proteins include small amounts of serum and tubular microglobulins. Uromodulin produced by the renal tubular epithelial ... acetoacetic acid and beta-hydroxybutyric acid. Elevated concentrations of ketones are not generally found in urine, as all ... Water The test does not measure beta-hydroxybutyric acid and it is only weakly sensitive to acetone when glycine is added to ...
A beta-2 microglobulin (B2M) tumor marker test measures the amount of B2M in the blood, urine, or cerebrospinal fluid. Its ... A beta-2 microglobulin test is usually a blood test, but may also be given as a 24-hour urine test, or as a cerebrospinal fluid ... A beta-2 microglobulin tumor marker test is most often given to people who have been diagnosed with certain cancers of the bone ... What is a beta-2 microglobulin tumor marker test?. This test measures the amount of a protein called beta-2 microglobulin (B2M ...
Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex ... Beta-2-microglobulinSequence analysis. Automatic assertion according to sequence analysisi ... Belongs to the beta-2-microglobulin family.SAAS annotation. Automatic assertion according to rulesi ... tr,B0UYS1,B0UYS1_DANRE Beta-2-microglobulin OS=Danio rerio OX=7955 GN=b2m PE=2 SV=1 ...
Beta-2 Microglobulin and Serum Cytokines x HAART. The safety and scientific validity of this study is the responsibility of the ... Cross-sectional study to assess the behavior of Beta-2 microglobulin and serum cytokines TNF-α, IFN-γ, IL-2, IL-4 and IL-10 as ... Objective: To assess the behavior of Beta-2 microglobulin and serum cytokines TNF-α, IFN-γ, IL-2, IL-4 and IL-10 as indicators ... Demographic, clinical and HAART data were reviewed, and Beta-2 microglobulin, serum cytokines (TNF-α, IFN-γ, IL-2, IL-4 and IL- ...
Browse our beta 2-Microglobulin ELISA catalog backed by our Guarantee+. ... beta chain of MHC class I molecules elisa kit, beta-2-microglobin elisa kit, beta-2-microglobulin elisa kit ... Our beta 2-Microglobulin ELISA Kits can be used in a variety of model species: Human, Rat. Use the list below to choose the ... Each beta 2-Microglobulin ELISA Kit is fully covered by our Guarantee+, to give you complete peace of mind and the support when ...
Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex ... Beta-2-microglobulinAdd BLAST. 98. Amino acid modifications. Feature key. Position(s). DescriptionActions. Graphical view. ... Belongs to the beta-2-microglobulin family.Curated. Keywords - Domaini. Immunoglobulin domain, Signal. Phylogenomic databases. ... sp,P30441,B2MG_HORSE Beta-2-microglobulin OS=Equus caballus OX=9796 GN=B2M PE=1 SV=1 ...
Abcam provides specific protocols for Anti-beta 2 Microglobulin antibody [B2M-01] (ab759) : Flow cytometry protocols, ...
MHC class I/beta 2-microglobulin complexes associate with TAP transporters before peptide binding.. Ortmann B1, Androlewicz MJ ... In human B-cell lines, however, class I/beta 2m dimers in the ER are physically associated with TAP molecules rather than ... Our results suggest that calnexin mediates class I/beta 2m dimerization, and subsequent binding of the dimers to TAP molecules ... beta 2m) peptide complex. Free class I heavy chains are associated in the ER with the chaperone calnexin. ...
beta 2m caused inhibition only when added to the virus preparation and not to the antibody-capture stage. We conclude that beta ... We postulate that CMV in fresh urine specimens is similarly coated with beta 2m, accounting for the failure to detect it by ... Detection of cytomegalovirus by ELISA in urine samples is inhibited by beta 2 microglobulin.. McKeating JA, Grundy JE, Varghese ... The addition of a known urinary protein of this molecular weight, beta 2 microglobulin (beta 2m; 11,700 daltons), inhibited the ...
Page last updated: 4/2/2015 10:20 PM RCPA Manual last revised: 9/02/2015 9:00 AM ...
A recurrent D-strand association interface is observed in beta-2 microglobulin oligomers.. Colombo, M., de Rosa, M., Bellotti, ... Crystal structure of the beta-2 microglobulin DIMC50 disulphide-linked homodimer mutant. *DOI: 10.2210/pdb3TM6/pdb ... β-2 microglobulin (β2m) is an amyloidogenic protein responsible for dialysis-related amyloidosis in man. In the early stages of ... β-2 microglobulin (β2m) is an amyloidogenic protein responsible for dialysis-related amyloidosis in man. In the early stages of ...
Shop a large selection of products and learn more about beta-2 Microglobulin Mouse anti-Human, Porcine, Clone: B2M-02, ... Beta-2 microglobulin is also found in free form in the plasma. The amino acid sequence of Beta-2-microglobulin is homologous to ... Beta 2-microglobulin is encoded by the B2M gene located on chromosome 15. A mutation in the Beta-2-microglobulin gene has been ... Beta-2-microglobulin (B2M) is a 12-14 kDa protein that is a subunit of the major histocompatibility complex (MHC) class I. ...
Beta-2 microglobulin (β2m) is a structural protein sub-unit of the class I major histocompatibility complex. β2m is composed of ... 2. Calabrese, M.F., Eakin, C.M., Wang, J.M., Miranker, A.D. (2008) Nat. Struct. Mol. Biol. 15, 965-971. ... Retrieved from "http://proteopedia.org/wiki/index.php/Molecular_playground/beta_2_microglobulin" ...
Beta 2-microglobulin is present in small amounts in serum, csf, and urine of normal people, and to a much greater degree in the ... Beta-2-microglobulin, B2M.. Introduction. ?2 microglobulin is an 11 kDa protein associated with the outer membrane of many ... B2 Microglobulin Human Recombinant produced in E.Coli is a non-glycosylated polypeptide chain having a molecular mass of 11.76 ... Human Beta 2 microglobulin levels can rise either because its rate of synthesis has increased (e.g. in AIDS, malignant ...
... beta 2m) values. Both neopterin and beta 2m levels increased with age and were higher among white than blacks (mean values for ... whites and blacks: neopterin, 5.06 vs 4.49 nmol/L; beta 2m, 1.36 vs 1.28 mg/L). Gender ... data from a population-based random sample of healthy adults was used to evaluate factors influencing neopterin and beta 2- ... beta 2m, 1.36 vs 1.28 mg/L). Gender differences were noted for beta 2m but not neopterin values (beta 2m males vs females: 1.37 ...
... does not associate with beta 2m when the mouse beta 2mb gene is transfected into the R1E transfectant expressing the truncated ... Beta 2-microglobulin is not required for cell surface expression of the murine class I histocompatibility antigen H-2Db or of a ... Beta 2-microglobulin is not required for cell surface expression of the murine class I histocompatibility antigen H-2Db or of a ... Beta 2-microglobulin is not required for cell surface expression of the murine class I histocompatibility antigen H-2Db or of a ...
Mouse Monoclonal Anti-beta 2-Microglobulin Antibody (B2M/1118) [PerCP]. Renal Failure & Tumor Marker. Validated: Flow, IHC-P. ... Blogs on beta 2-Microglobulin. There are no specific blogs for beta 2-Microglobulin, but you can read our latest blog posts. ... beta 2 microglobulin is a 12KDa protein with a pI of 5.6. Serum beta 2 microglobulin levels are a reflection of cell turnover. ... FAQs for beta 2-Microglobulin Antibody (NBP2-47702PCP) (0). There are no specific FAQs related to this product. Read our ...
The value of beta 2-MG in plasma as an index of inflammatory activity in RA is questioned. ... 33% of the patients had increased concentrations of beta 2 MG, but the levels were found to correlate poorly with the values of ... Using the immunodiffusion method we have measured the plasma levels of beta 2-MG in 135 patients with rheumatoid arthritis (RA ... A simple and inexpensive method is described for the determination of beta 2-microglobulin (beta 2-MG) by enzyme-amplified ...
Malignant lymphoma? do I need nuclear scan or beta-2-microglobulin test?. Dec 12, 2001 Im a 25 yrs old male with no other ... In terms of your questions about beta-2-microglobulin and nuclear scans, neither test is indicated based on what you have ... 3) Would you recommend other tests (including a beta 2 microglobulin - I heard it is lymphoma marker), or a nuclear scan? ... 2) If it would be malignant lymphoma, wouldnt it show other changes on these blood tests? ...
MHC CLASS I H-2KB HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND AN (L4V) MUTANT OF THE VESICULAR STOMATITIS VIRUS ...
ß2-microglobulin (B2M) is a principal component of the Major Histocompatibility Complex (MHC) class I molecule, a terry ... Localization: ß2-microglobulin is mainly on the cell surface and occasionally cytoplasmic. Staining: Beta-2-microglobulin as ... Localization: ß2-microglobulin is mainly on the cell surface and occasionally cytoplasmic. Staining: Beta-2-microglobulin as ... Beta-2-microglobulin antibody. Not available. Mouse. IgG1. D2E9. Aff - Purified. Hu. E, E(capture), F, ICC/IF, WB. 0.5 mg / € ...
We tested whether beta 2m-dependent T cells were essential for Th2 cell-mediated allergic reactions by treating wild-type, beta ... Beta 2-microglobulin-dependent T cells are dispensable for allergen-induced T helper 2 responses.. Y Zhang, K H Rogers, D B ... OVA-treated beta 2m -/- mice had circulating levels of total and OVA-specific IgE, pulmonary eosinophilia, and expression of IL ... alpha/beta+ CD8+ T cells, most of which require beta 2m for their development, have also been proposed as positive regulators ...
The research teams found that a blood-borne molecule (beta-2 microglobulin, or B2M, a component of a larger molecule called MHC ... beta-2 micro globulin, B2M, MHC, Nature Medicine ...
Mouse Monoclonal beta-2 Microglobulin antibody AA 21-100 for IC, FACS, IHC, ELISA, WB. Order anti-beta-2 Microglobulin antibody ... Product Details anti-beta-2 Microglobulin Antibody Handling Application Details Target Details back to top ... anti-beta-2 Microglobulin antibody (beta-2-Microglobulin) (AA 21-100) beta-2 Microglobulin antibody (beta-2-Microglobulin) (AA ...
Active rheumatoid arthritis and kidney disease can be partially diagnosed with a B2 microglobulin test. Visit RapidTest for kit ... Material Provided with B2 Microglobulin ELISA Kit:. 1. Microplate: wells coated with Anti-Beta-2 MG antibody. 2. Sample diluent ... Beta 2 Microglobulin ELISA kit description:. The Beta-2 Microglobulin ELISA test is an enzyme immunoassay (EIA) for the ... Human Beta-2 Microglobulin (B2MG) is an 11.8 kD protein identical to the light chain of the HLA-A, -B, and -C antigen. B2MG is ...
Furthermore, LA45 is not associated with beta 2-m. On the other hand, we could show that the separation of HLA-A,B,C and beta ... The 90/45 kD LA45 proteins thus appear to be non-beta 2m-associated MHC class I alpha chains that are selectively expressed by ... Activated human T lymphocytes express MHC class I heavy chains not associated with beta 2-microglobulin.. E Schnabl, H ... Activated human T lymphocytes express MHC class I heavy chains not associated with beta 2-microglobulin. ...
Beta 2 Microglobulin, and Adiponectin Bronchopulmonary dysplasia (BPD) is a respiratory distress syndrome caused by chronic ... Beta 2 Microglobulin, and Adiponectin: Crosstalk in Early Prediction of Bronchopulmonary Dysplasia in Egyptian Preterm . J Mol ... mRNA gene expression in broncho-alveolar lavage and urinary beta 2 microglobulin (β2MG) for early prediction of lung injury or ... Citation: Soliman NA, Keshk WA, El-Farargy MS (2015) Neutrophil-Gelatinase-Associated Lipocalin 2, Krebs Von den Lungen-6, ...
2012) Comparative Analysis of CA 125, Ferritin, Beta-2 Microglobulin, Lactic Dehydrogenase Levels in Serum and Peritoneal Fluid ... 2012) Comparative Analysis of CA 125, Ferritin, Beta-2 Microglobulin, Lactic Dehydrogenase Levels in Serum and Peritoneal Fluid ... JOURNAL NAME: Yangtze Medicine, Vol.2 No.2, June 11, 2018. ABSTRACT: Purpose: To investigate the ferritin distribution in ...
Background: Beta-trace protein (BTP) and beta-2-microglobulin (B2M) are novel markers of renal dysfunction associated with ... Abstract 18415: Beta-trace Protein and Beta-2-microglobulin are Independent Predictors of All-cause and Cardiovascular ... Abstract 18415: Beta-trace Protein and Beta-2-microglobulin are Independent Predictors of All-cause and Cardiovascular ... Abstract 18415: Beta-trace Protein and Beta-2-microglobulin are Independent Predictors of All-cause and Cardiovascular ...
Rate and mechanism of generation of beta 2-microglobulin mutants from a heterozygous murine cell line.. T V Rajan, L F Moffat ... Rate and mechanism of generation of beta 2-microglobulin mutants from a heterozygous murine cell line. ... Rate and mechanism of generation of beta 2-microglobulin mutants from a heterozygous murine cell line. ... Rate and mechanism of generation of beta 2-microglobulin mutants from a heterozygous murine cell line. ...
beta 2 Microglobulin (F21-21), 0.25 mg. Like their mammalian counterparts, avian MHC Class I molecules (also known as B-F ... Recommended Secondary Antibodies for beta 2 Microglobulin (F21-21) (11 products). Catalog No.. Host. Clone/Iso.. Pres.. React. ... The betea2-microglobulin subunit (Mr approx. 14 kDa) of avian MHC Class I molecules. Species:. Avian, Chicken. ... Product Description for beta 2 Microglobulin (F21-21). Mouse anti Birds, Chicken beta 2 Microglobulin (F21-21) F21-21. ...
  • This antibody reacts with beta2-microglobulin associated with cell-surface MHC Class I molecules and other membrane antigens as well as with soluble beta2-microglobulin. (fishersci.com)
  • 44 kDa) non-covalently bound to the invariant beta2-microglobulin subunit (Mr approx. (acris-antibodies.com)
  • Beta2 microglobulin, also known as B2M, is a component of MHC class I molecules, Involved in the presentation of peptide antigens to the immune system. (creativebiomart.net)
  • Juraschek SP, Coresh J, Inker LA, Rynders GP, Eckfeldt JH, Selvin E. The effects of freeze-thaw on beta-trace protein and beta2-microglobulin assays after long-term sample storage. (cdc.gov)
  • The cerebrospinal fluid and plasma concentrations of gamma-trace beta2 microglobulin at various ages and in neurological disorders. (thefreedictionary.com)
  • This technology may be used as a vaccine to generate immunity to the HIV virus by stimulating antibodies to beta2 microglobulin (B2m), which is a cellular antigen that is common in high concentrations to all known strains of the virus. (thefreedictionary.com)
  • 1. Ikeda M, Ezaki T, Tsukahara T, et al: Threshold levels of urinary cadmium in relation to increases in urinary beta2-microglobulin among general Japanese populations. (testcatalog.org)
  • Approval for the lixelle® ß2-microglobulin apheresis column (also called the beta2-microglobulin apheresis column or ß2m). (fda.gov)
  • They are transported into the ER by the transporters associated with antigen processing (TAP), a complex formed from two subunits, TAP.1 and TAP.2 (refs 3-5). (nih.gov)
  • Here, we show that the mouse class I antigen H-2Db is expressed at the cell surface even when there is no beta 2m present within the cell. (pnas.org)
  • We show further that a deletion construct of the Db gene, which consists of exon 1 linked to exons 4-8, expresses a truncated Db antigen lacking domains 1 and 2 [Db-(1 + 2)] at the cell surface after transfection into the R1E line. (pnas.org)
  • This suggests that interactions with domains 1 and 2 are important for the paired association of domain 3 and beta 2m in the native Db antigen. (pnas.org)
  • Human Beta-2 Microglobulin (B2MG) is an 11.8 kD protein identical to the light chain of the HLA-A, -B, and -C antigen. (rapidtest.com)
  • As assessed by immunization with protein antigen, infection with Leishmania major, embolization with eggs of Schistosoma mansoni, intestinal infection with Nippostrongylus brasiliensis, or induction of airway hyperreactivity to aerosolized antigen, beta 2m-deficient mice developed functional type 2 immune responses that were not substantially different than those in wild-type mice. (rupress.org)
  • Beta 2 Microglobulin is a human leukocyte antibody (HLA) major histocompatibility antigen that exists with increased numbers on white blood cells (WBCs) and particularly on lymphatic cells. (wbccount.org)
  • Skin graft rejection elicited by beta 2-microglobulin as a minor transplantation antigen involves multiple effector pathways: role of Fas-Fas ligand interactions and Th2-dependent graft eosinophil infiltrates. (ac.be)
  • This test measures the amount of a protein called beta-2 microglobulin (B2M) in the blood, urine, or cerebrospinal fluid (CSF). (medlineplus.gov)
  • A beta-2 microglobulin test is usually a blood test, but may also be given as a 24-hour urine test , or as a cerebrospinal fluid (CSF) analysis. (medlineplus.gov)
  • Detection of cytomegalovirus by ELISA in urine samples is inhibited by beta 2 microglobulin. (nih.gov)
  • We conclude that beta 2m in urine prevents the detection of CMV by ELISA by binding to the virus and masking its antigenic determinants and we calculate that of the order of 10(5) molecules of beta 2m bind to each particle of cell culture-grown CMV. (nih.gov)
  • We postulate that CMV in fresh urine specimens is similarly coated with beta 2m, accounting for the failure to detect it by ELISA. (nih.gov)
  • Beta 2-microglobulin is present in small amounts in serum, csf, and urine of normal people, and to a much greater degree in the urine and plasma of patients with tubular proteinaemia, renal failure, or kidney transplants. (prospecbio.com)
  • beta 2-Microglobulin levels in serum and urine of rheumatoid arthritis patients on gold therapy. (bmj.com)
  • The levels of beta 2-microglobulin (beta 2-m) in serum and urine of 24 seropositive patients with rheumatoid arthritis (RA) treated with regular gold (sodium aurothiomalate) injections have been investigated. (bmj.com)
  • No correlation between dose of gold received and the levels of beta 2-m in the urine could be established. (bmj.com)
  • There was also no correlation between the erythrocyte sedimentation rate (ESR) or total lymphocyte count and beta 2-m levels in serum or urine. (bmj.com)
  • Beta-2-Microglobulin is unstable in acidic urine (less than pH 6). (specialtylabs.com)
  • Highly pure beta 2 microglobulin from human urine. (bio-rad-antibodies.com)
  • Measurement of beta 2-microglobulin, retinol-binding protein, alpha 1-microglobulin and urine protein 1 in healthy children using enzyme-linked immunosorbent assay. (semanticscholar.org)
  • Enzyme-linked immunosorbent assays (ELISA) have been developed for the measurement of beta 2-microglobulin (B2M), retinol-binding protein (RBP), alpha 1-microglobulin (A1M) and urine protein 1 (UP1) in children. (semanticscholar.org)
  • In a patient with renal disease, when blood and urine β 2 M levels are obtained simultaneously, one can differentiate glomerular from tubular disease. (wbccount.org)
  • To measure Beta-2 Microglobulin levels in urine, the patient is required to collect urine for a 24 hours period. (wbccount.org)
  • Beta-2 Microglobulin is unstable in highly acidic urine which causes misleading lower B2M levels to be measured. (wbccount.org)
  • Also, when high B2M levels are found in blood, this will cause increased renal production of Beta-2 Microglobulin which exceeds the ability of renal tubule to absorb B2M leading to high B2M levels in urine. (wbccount.org)
  • Beta-2 Microglobulin (B2M) is a low molecular weight protein which is found in minute quantities in various body fluids such as blood and urine. (sekisuidiagnostics.com)
  • The excretion of beta-2- microglobulin in the urine was significantly higher among the uranium workers. (cdc.gov)
  • The possibility of differences not only in titre but also in the specificity of heterologous and homologous anti-β 2 m antibodies are discussed. (elsevier.com)
  • The method of beta-2-microglobulin evaluation has enough high specificity, sensitivity in diagnostic hypertensive nephropathy. (edu.ua)
  • In humans, the β2 microglobulin protein is encoded by the B2M gene. (wikipedia.org)
  • Mice models deficient for the β2 microglobulin gene have been engineered. (wikipedia.org)
  • The human beta 2-microglobulin gene. (wikipedia.org)
  • Beta 2-microglobulin is encoded by the B2M gene located on chromosome 15. (fishersci.com)
  • A mutation in the Beta-2-microglobulin gene has been shown to result in hypercatabolic hypoproteinemia. (fishersci.com)
  • This was established by transfecting the H-2Db gene into the R1E cell line, which lacks beta 2m. (pnas.org)
  • unexpectedly, Db-(1 + 2) does not associate with beta 2m when the mouse beta 2mb gene is transfected into the R1E transfectant expressing the truncated Db. (pnas.org)
  • for example, research studies have shown that nearly one-third of diffuse large B cell lymphomas contain mutations that ictivate ß2-microglobulin gene function, thereby allowing tumor cells to escape immune detection. (acris-antibodies.com)
  • This study was conducted to evaluate levels of Krebs Von den Lungen-6 (KL-6) and adiponectin in cord blood, neutrophil-gelatinase-associated lipocalin 2 (NGAL2) mRNA gene expression in broncho-alveolar lavage and urinary beta 2 microglobulin (β2MG) for early prediction of lung injury or possible involvement of those molecules in BPD pathogenesis and development. (omicsonline.org)
  • The ß 2 -m chain may be affected by the nef gene in HIV, preventing CD8+ T lymphocytes from recognizing the virus. (thefreedictionary.com)
  • Recombinant Cynomolgus monkey Beta-2-microglobulin is produced by our Mammalian expression system and the target gene encoding Ile21-Met119 is expressed with a Fc tag at the C-terminus. (bonopusbio.com)
  • Genomic characterization and sequence diversity of the β2-microglobulin gene in the miiuy croaker, Miichthys miiuy. (semanticscholar.org)
  • Beta-2-microglobulin regulator is a protein in humans that is encoded by the B2MR gene. (wikipedia.org)
  • Beta 2-microglobulin gene mutations: a study of established colorectal cell lines and fresh tumors. (ox.ac.uk)
  • The technique of single-strand conformation polymorphism (SSCP) was used to screen a series of 37 established colorectal cell lines, 22 fresh tumor samples, and 22 normal DNA samples for mutations in the beta 2-microglobulin gene. (ox.ac.uk)
  • Full length Clone DNA of Rat beta-2 microglobulin with N terminal His tag. (sinobiological.com)
  • The clone F21-21 also reacts with turkey β2-microglobulin. (arigobio.com)
  • This was then used to clone a full-length beta 2-microglobulin cDNA from carp. (semanticscholar.org)
  • Our range of Beta 2 Microglobulin antibodies (also known as B2M) come in a variety of formats and to a selection of target species. (bio-rad-antibodies.com)
  • An antigenic determinant of human beta 2-microglobulin masked by the association with HLA heavy chains at the cell surface: analysis using monoclonal antibodies. (immuquest.com)
  • Expression of beta 2-microglobulin was examined using a series of monoclonal antibodies in an ELISA system. (ox.ac.uk)
  • The Beta-2 Microglobulin ELISA assay allows the quantitative determination of B2MG from serum. (rapidtest.com)
  • Human beta 2 microglobulin (B2MG) is a component of major histocompatibility complex 1 (MHC1). (arigobio.com)
  • ß2-microglobulin (B2M) is a principal component of the Major Histocompatibility Complex (MHC) class I molecule, a terry membrane protein complex that displays fragments derived from proteolyzed cytosolic proteins on the surface of cells for recognition by the surveillance immune system. (acris-antibodies.com)
  • The research teams found that a blood-borne molecule (beta-2 microglobulin, or B2M, a component of a larger molecule called MHC) which plays an important role in the adaptive immune system, greatly increases as we age, and can act adversely in the brain , in ways not related to immunity-blocking the regeneration of brain cells, thus promoting cognitive decline . (jdfaf.org)
  • Beta-2 microglobulin (B2M) is a component of the major histocompatibility complex (MHC) class I molecule and has been studied as a biomarker of kidney function, cardiovascular diseases and mortality. (elsevier.com)
  • These cells are selected by the nonpolymorphic major histocompatibility complex (MHC) class I molecule, CD1, and are deficient in beta 2-microglobulin (beta 2m)-null mice. (rupress.org)
  • To address this possibility, we measured plasma levels of beta-2-microglobulin (β2m), a molecule that associates with MHC I and is indicative of MHC I expression, in 36 children with autism, 28 typically developing controls and subjects with developmental disabilities (n=16) but not autism. (elsevier.com)
  • beta 2-Microglobulin Monoclonal antibody specifically detects beta 2-Microglobulin in Human samples. (fishersci.com)
  • 1. Hilgert I, Horejsi V, Kristofova H.: The use of murine monoclonal antibody B2M-01 for detection and purification of human beta 2-microglobulin. (acris-antibodies.com)
  • The beta 2-Microglobulin Antibody (B2M / 961) [PerCP] from Novus Biologicals is a mouse monoclonal antibody to beta 2-Microglobulin. (vwr.com)
  • 66207-1-Ig targets Beta-2-Microglobulin in WB, IHC, ELISA applications and shows reactivity with human samples. (ptglab.com)
  • Serum beta 2 microglobulin levels are a reflection of cell turnover. (novusbio.com)
  • 2015). 'Serum Beta-2 Microglobulin: a Possible Marker for Disease Progression in Egyptian Patients with Chronic HCV Related Liver Diseases', Asian Pacific Journal of Cancer Prevention , 16(17), pp. 7825-7829. (waocp.org)
  • A significant increase of urinary beta 2-m levels was found in the gold-treated RA group. (bmj.com)
  • We conclude that serum and urinary beta 2-m levels appear to be poor indices of joint inflammation, but sequential urinary beta 2-m levels may prove valuable in monitoring the development of renal tubular lesions due to gold therapy. (bmj.com)
  • Urinary Beta-2-Microglobulin is used as an indicator of renal impairment. (specialtylabs.com)
  • The ratios of urinary β2-microglobulin and NAG to creatinine vary with age in children. (semanticscholar.org)
  • 2. Moriguchi J, Ezaki T, Tsukahara T, et al: Comparative evaluation of four urinary tubular dysfunction markers, with special references to the effects of aging and correction for creatinine concentration. (testcatalog.org)
  • Objectives: To determine the prevalence of early proximal tubular dysfunction, measured by urinary excretion of retinol-binding protein (RBP) and beta-2-microglobulin (B2M), in patients with the idiopathic nephrotic syndrome and to investigate the value of these tests in predicting steroid responsiveness. (elsevier.com)
  • The aim of the present study was to establish clinical, diagnostic and predicted significance of beta-2-microglobulinuria as a marker of renal damage at essential hypertension and to determine the prevalence of increased urinary beta-2-microglobulin excretion in essential hypertension. (edu.ua)
  • The urinary albumin and beta-2-microglobulin excretion were determined by immune-enzyme assay. (edu.ua)
  • We conclude that the increased urinary beta-2-microglobulin excretion in patients with essential hypertension is a significant marker of the hypertensive nephropathy. (edu.ua)
  • Serum and urinary beta-2-microglobulin were measured by radioimmunoassay. (cdc.gov)
  • citation needed] Levels of β2 microglobulin can be elevated in multiple myeloma and lymphoma, though in these cases primary amyloidosis (amyloid light chain) and secondary amyloidosis (amyloid associated protein) are more common. (wikipedia.org)
  • However, this mutation apparently precludes the formation of long amyloid fibrils and instead progress to off-pathway oligomers [2] . (proteopedia.org)
  • In an article appearing in the December 2007 issue of the JASMS, researchers at Leeds describe the successful separation and analysis of various folded forms of the proteins cytochrome c and beta-2-microglobulin , an achievement the Ashcroft Laboratory hopes will lead to a more complete understanding of the biological processes responsible for amyloid fibril formation, bacterial pilus aggregation and virus capsid assembly -- all associated with debilitating diseases. (thefreedictionary.com)
  • Here we consider beta-2-microglobulin (beta 2m), the MHC-1 light chain component responsible for dialysis-related amyloidosis, which can give rise to amyloid fibrils in vitro under various experimental conditions, including low and neutral pH. (epfl.ch)
  • Lastly, the analogy of the spectra recorded on beta 2m fibrils grown at different pH values hints at a conserved architecture of the amyloid species thus obtained. (epfl.ch)
  • Histological analysis, immunohistological staining, and electron microscopic examination of the surgically removed tumour showed massive deposits of beta 2-microglobulin (beta 2-M) amyloid. (bmj.com)
  • Here we show using Fourier transform infrared spectroscopy that amyloid-like fibrils formed in vitro from natively folded or unfolded β2-microglobulin (the protein associated with dialysis-related amyloidosis) adopt an identical β-sheet architecture. (whiterose.ac.uk)
  • The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. (arigobio.com)
  • Characterization of amyloid fibrils of human beta-2-microglobulin by high-resolution magic-angle spinning NMR. (bionmr.com)
  • Amyloid deposits are made of the beta-2 microglobulin protein that accumulated in tissues, particularly around joints, when it cannot be excreted by the kidney because of renal failure. (bu.edu)
  • [ 2 ] Many classic eponymic diseases were later found to be related to a diverse array of misfolded polypeptides (amyloid) that contain the common beta-pleated sheet architecture. (medscape.com)
  • Using the immunodiffusion method we have measured the plasma levels of beta 2-MG in 135 patients with rheumatoid arthritis (RA) and normal serum creatinine levels. (bmj.com)
  • OUTCOME MEASURES: Patients completed a questionnaire and had toe and arm blood pressure (toe-arm index), as well as serum β2 microglobulin and creatinine, measured. (up.ac.za)
  • In patients with aminoglycoside toxicity, β 2 M become elevated even before creatinine. (wbccount.org)
  • The aim of this investigation was to study the plasma levels of beta-trace protein, beta-2-microglobulin and cystatin C in pre-eclampsia, and to determine the diagnostic performance of these proteins compared to that of urate and creatinine. (lu.se)
  • The variable which best predicted beta-2- microglobulin clearance relative to creatinine clearance was the length of time the employee had worked in the yellowcake area. (cdc.gov)
  • The three target proteins - beta-2-microglobulin , cystatin C, and retinol binding protein - are FDA approved clinical markers for in-vitro diagnosis of kidney disease and renal failure. (thefreedictionary.com)
  • Beta-2-microglobulin (b2m), Cystatin-C (cyc), and Retinol- binding protein (rbp). (thefreedictionary.com)
  • β-2 microglobulin (β2m) is an amyloidogenic protein responsible for dialysis-related amyloidosis in man. (rcsb.org)
  • Renal transplant rejection: Because excretion of β 2 M is renal, renal rejection reduces excretion and blood levels of β 2 M increase. (wbccount.org)
  • Renal excretion of beta- 2-microglobulin was used as an indicator of tubular reabsorption of low molecular weight proteins. (cdc.gov)
  • β2 microglobulin also known as B2M is a component of MHC class I molecules, MHC class I molecules have α1, α2, and α3 proteins which are present on all nucleated cells (excludes red blood cells). (wikipedia.org)
  • Beta-2-microglobulin (B2M) is a component of MHC class I molecules, which are present on the surface of nearly all nucleated cells. (ptglab.com)
  • B2M, also known as β2-Microglobulin or CDABP0092, is a component of MHC class I molecules found expression in all nucleated cells (excludes red blood cells). (sinobiological.com)
  • We have used solid-state NMR to probe the structural features of fibrils formed by full-length beta 2m (99 residues) at pH 2.5 and pH 7.4. (epfl.ch)
  • B2 Microglobulin Human Recombinant produced in E.Coli is a non-glycosylated polypeptide chain having a molecular mass of 11.76 kDa. (prospecbio.com)
  • 2. The recombinant nucleic acid of claim 1, wherein said first region and said second region are in proximity to each other or are adjacent to each other or overlap with each other or one encompasses the other. (freepatentsonline.com)
  • 3. The recombinant nucleic acid of claim 2, wherein the 3′ end of the first region is adjacent to the 5′ end of the second region or the 3′ end of the second region is adjacent to the 5′ end of the first region or the first region is located within the second region. (freepatentsonline.com)
  • Beta-2-microglobulin (β2M) associated amyloidosis has been seen in patients with chronic renal failure after long-term hemodialysis. (ovid.com)
  • Prevalence of histological beta 2-microglobulin amyloidosis in CAPD patients compared with hemodialysis patients. (ugent.be)
  • Prognostic Role of Beta-2 Microglobulin in Patients with Light Chain Amyloidosis Treated with Autologous Stem Cell Transplantation. (stembook.org)
  • Pseudotumoral amyloidosis of beta 2-microglobulin origin in the buttock of a patient receiving long term haemodialysis. (bmj.com)
  • Beta-2 microglobulin amyloidosis is caused by chronic renal failure and often occurs in patients who are on dialysis for many years. (bu.edu)
  • Beta-2 microglobulin levels might also be elevated in multiple myeloma and lymphoma cases. (prospecbio.com)
  • 2) If it would be malignant lymphoma, wouldn't it show other changes on these blood tests? (thebody.com)
  • 3) Would you recommend other tests (including a beta 2 microglobulin - I heard it is lymphoma marker), or a nuclear scan? (thebody.com)
  • Lane 1: RAJI Human Burkitt lymphoma cell line.Lane 2: EL4 Mouse lymphoblastic lymphoma cell line. (acris-antibodies.com)
  • Therefore, β 2 M are increased in patients with malignancies (especially lymphoma, leukemia, or multiple myeloma) or in patients with chronic severe inflammatory diseases. (wbccount.org)
  • Beta 2 Microglobulin test is used as a tumor marker for blood tumors such as lymphoma or leukemia. (wbccount.org)
  • 33% of the patients had increased concentrations of beta 2 MG, but the levels were found to correlate poorly with the values of several variables generally used as indices of the degree inflammatory activity in RA. (bmj.com)
  • 2012) Comparative Analysis of CA 125, Ferritin, Beta-2 Microglobulin, Lactic Dehydrogenase Levels in Serum and Peritoneal Fluid in Patients with Ovarian Neoplasia. (scirp.org)
  • Several studies have shown a reduction in many inflammation-related parameters, better nutritional indices, reduced beta-2-microglobulin levels, and improved anemia management achieved with less erythropoietin stimulating agents when hemodialysis patients are treated with ultrapure dialysate, in comparison with standard dialysate. (thefreedictionary.com)
  • Serial determinations of beta 2-microglobulin, lactoferrin and lysozyme in CSF were performed in 14 patients with acute cerebrovascular lesions. (ahajournals.org)
  • BACKGROUND: Peripheral arterial disease (PAD) is common in patients with type 2 diabetes mellitus. (up.ac.za)
  • The objective of the study was to evaluate the diagnostic value of β2 microglobulin for PAD in patients with diabetes and varying renal function. (up.ac.za)
  • Blood London have been providing Beta 2 Microglobulin (Serum) on a self-referral basis to patients in Central and Greater London for over 20 years. (blood.london)
  • The frequency and concentration of specific factors binding β 2 microglobulin were investigated in sera and synovial fluids of patients and in sera of normal controls. (elsevier.com)
  • High anti-β 2 m activity was detected in the sera of adult RA patients, particularly in those of with extra-articular disease. (elsevier.com)
  • Similarly, anti-β 2 m was present in the synovial fluids of RA but not of osteoarthrosis patients. (elsevier.com)
  • Falus, A , Meretey, K & Bozsoky, S 1981, ' Prevalence of anti-beta-2 microglobulin autoantibodies in sera of rheumatoid arthritis patients with extra-articular manifestations ', Annals of the Rheumatic Diseases , vol. 40, no. 4, pp. 409-413. (elsevier.com)
  • Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. (bonopusbio.com)
  • The level of beta-2-microglobulinuria was measured in a group of 46 patients with essential hypertension (21 women, 25 men) and in 17 healthy subjects (as control group). (edu.ua)
  • The beta-2-microglobulinuria value in hypertensive patients was statistically increase from that observed in normal controls. (edu.ua)
  • IMSEAR at SEARO: Decline in beta-2 microglobulin levels after antitubercular therapy in tubercular patients with HIV infection. (who.int)
  • Wanchu A, Arora S, Bhatnagar A, Sud A, Bambery P, Singh S. Decline in beta-2 microglobulin levels after antitubercular therapy in tubercular patients with HIV infection. (who.int)
  • Eighty-one patients were enrolled, 57 in stages III or IV, International Prognostic Index (IPI) 0 or 1 ( n = 26), 2 ( n = 19), 3 ( n = 20) and 4 or 5 ( n = 16), and median CD4 lymphocyte count of 0·158 × 10 9 /l. (wiley.com)
  • The saliva in Sögren`s syndrome patients has a high level of beta 2 microglobulin reflecting progression of the disease and inflammatory process at glandular epithelium. (clinicaltrials.gov)
  • These mice demonstrate that β2 microglobulin is necessary for cell surface expression of MHC class I and stability of the peptide binding groove. (wikipedia.org)
  • MHC class I/beta 2-microglobulin complexes associate with TAP transporters before peptide binding. (nih.gov)
  • Here we show that the TAP molecules are intimately involved in the assembly of the class I/beta 2-microglobulin (beta 2m) peptide complex. (nih.gov)
  • β 2 -Microglobulin is a cell membrane-associated 100-amino-acid peptide, a component of the lymphocyte HLA complex. (5minuteconsult.com)
  • Exon 1 (including the leader peptide sequence) and exon 2 were screened separately. (ox.ac.uk)
  • The spectroscopic inspection between pH 2 and pH 12 successfully extracted the critical pH point (pH o ) at which the color change of the amyloidogenic peptide-coated nano-gold colloids occurred due to aggregation of the nano-gold colloids. (mdpi.com)
  • Confocal microscopy of Hman Beta-2-microglobulin-transfected canine cells labeled A) with B2M-01 antibody Alexa Fluor® 647 conjugate and B) with Alexa Fluor® 647 conjugated Mouse IgG2a Isotype Control. (acris-antibodies.com)
  • We offer beta 2-Microglobulin ELISA Kits for use in common research applications. (novusbio.com)
  • Our beta 2-Microglobulin ELISA Kits can be used in a variety of model species: Human, Rat. (novusbio.com)
  • Choose from our beta 2-Microglobulin ELISA Kits. (novusbio.com)
  • Murine NK1.1+ (CD4+ or CD4-CD8-) alpha/beta+ T cells comprise a beta 2-microglobulin (beta 2m)-dependent cell population that rapidly produces IL-4 after cell activation in vitro and in vivo and has been proposed as a source of IL-4 for Th2 cell differentiation. (rupress.org)
  • A number of investigations have established the critical role of interleukin 4 (IL-4) in mediating the development of T helper (Th)2 effector cells in vitro and in vivo. (rupress.org)
  • What is a beta-2 microglobulin tumor marker test? (medlineplus.gov)
  • A beta-2 microglobulin tumor marker test is most often given to people who have been diagnosed with certain cancers of the bone marrow or blood. (medlineplus.gov)
  • Why do I need a beta-2 microglobulin tumor marker test? (medlineplus.gov)
  • Beta-2-microglobulin that protein can be used as a prognostic marker for HIV infection. (fishersci.com)
  • 2. Drbal K, Angelisova P, Hilgert I, Cerny J, Novak P, Horejsi V.: A proteolytically truncated form of free CD18, the common chain of leukocyte integrins, as a novel marker of activated myeloid cells. (acris-antibodies.com)
  • Innovative Research's Human High Purity Lyophilized Beta-2 Microglobulin Serum is an endogenous marker for renal function and has been shown to be an independent predictor of mortality in older adults. (innov-research.com)
  • Beta-2 microglobulin (β2 microglobulin) has been proposed as a diagnostic marker for PAD. (up.ac.za)
  • The plasma levels of cystatin C and beta-2-microglobulin are further increased in preeclampsia, and the cystatin C level has been reported to be a reliable marker for the disease. (lu.se)
  • Beta-2 microglobulin (B2M) is a useful marker to study the state of immune activation among the HIV infected. (who.int)
  • The 90/45 kD LA45 proteins thus appear to be non-beta 2m-associated MHC class I alpha chains that are selectively expressed by activated but not by resting human T lymphocytes. (rupress.org)
  • The plasma levels of low molecular mass proteins, e. g. beta-trace protein, beta-2-microglobulin and cystatin C, are increased in the third trimester of normal pregnancy. (lu.se)
  • The upper reference limits ( parametric 97.5 percentile) were 2.57 mg/l for beta-2-microglobulin, 0.72 mg/l for beta-trace protein and 1.37 mg/l for cystatin C. ROC analysis showed similar diagnostic performance for the 3 proteins, with b-trace protein displaying the best diagnostic performance of all the analytes. (lu.se)
  • Lactoferrin, lysozyme, and beta 2-microglobulin in cerebrospinal fluid. (ahajournals.org)
  • Recognizes a protein of 12 kDa, identified as microglobulin. (biotium.com)
  • Low levels of β2 microglobulin can indicate non-progression of HIV. (wikipedia.org)
  • β2 microglobulin levels cannot, however, distinguish between monoclonal gammopathy of undetermined significance (MGUS), which has a better prognosis, and smouldering (low grade) myeloma. (wikipedia.org)
  • Levels of beta 2 microglobulin can be used to assess renal function in kidney transplant recipients. (fishersci.com)
  • Human Beta 2 microglobulin levels can rise either because its rate of synthesis has increased (e.g. in AIDS, malignant monoclonal plasma cell dyscrasia, solid tumors and autoimmune disease) or because of impaired renal filtration (e.g. due to renal insufficiency, graft rejection or nephrotoxicity induced by post-transplantation immunosuppressive therapy). (prospecbio.com)
  • Neopterin and beta 2m were correlated in this healthy adult population (adjusted r = 0.53, P = 0.001), yet no other interrelationships with numerous biologic markers except between beta 2m and serum-soluble interleukin-2 receptor levels (adjusted r = .41, P = 0.05) were observed. (rti.org)
  • Plasma levels of beta 2-microglobulin in rheumatoid arthritis. (bmj.com)
  • OVA-treated beta 2m -/- mice had circulating levels of total and OVA-specific IgE, pulmonary eosinophilia, and expression of IL-4, IL-5, and IL-13 mRNA in bronchial lymph node tissue similar to that of OVA-treated wild-type mice. (rupress.org)
  • In this study an attempt was made to correlate plasma levels of immune activation markers neopterin, beta-2-microglobulin ([beta]2M), and soluble tumour necrosis factor alpha-receptor type I (sTNF[alpha]-RI) with the presence of active TB in HIV-infected and uninfected individuals, and to study the changes following anti-tuberculosis treatment (ATT). (thefreedictionary.com)
  • Evaluation showed a statistically significant drop of the pre-dialysis level of the toxin beta-2-microglobulin (Beta(2)m) compared to baseline levels. (thefreedictionary.com)
  • Peak levels of lactoferrin and lysozyme were noted on day 2-3 after onset of symptoms. (ahajournals.org)
  • beta 2-microglobulin gradually increased reaching peak levels on day 4-5 and remained elevated even 2 weeks after the onset of symptoms. (ahajournals.org)
  • Low levels of B2M(β2 microglobulin) can indicate non-progression of HIV. (sinobiological.com)
  • When central nervous system (CNS) involvement with these neoplasms is suspected, β 2 M can be measured in the CNS fluid and compared to blood levels. (wbccount.org)
  • When Radioimmunoassay (RIA) methods are used to measure Beta-2 Mircroglobulin levels, the results could be inaccurate if the patient had a recent nuclear imaging. (wbccount.org)
  • High Beta-2 Microglobulin Levels are also associated with Chronic Inflamtion. (wbccount.org)
  • High Beta-2 Microglobulin levels occurs when the body experience high levels of production and destruction of lymphocyte cells and other bone marrow cells. (wbccount.org)
  • 2 mg/L. However, with respect to multiple myeloma, the levels of β2 microglobulin may also be at the other end of the spectrum. (shapeways.com)
  • In this study, the maternal plasma levels of beta 2-microglobulin, beta-trace protein and cystatin C were all significantly elevated in pre-eclampsia compared to those of healthy pregnant women, and displayed similar diagnostic performance for diagnosing pre-eclampsia. (lu.se)
  • The normal levels are 1,2 +/- 0,7 microg/ml, and for primary Sjögren`s syndrome 5,3 +/- 4,6 microg/ml. (clinicaltrials.gov)
  • Characterization of beta 2-microglobulin transcripts from two teleost species. (semanticscholar.org)
  • The chemiluminescent substrate, a phosphate ester of adamantyl dioxetane, in the presence of alkaline phosphatase produces light proportional to the concentration of the beta-2 microglobulin in the sample. (testcatalog.org)
  • Serum concentration of beta- 2-microglobulin was significantly higher among uranium workers than comparisons. (cdc.gov)
  • Detects human beta 2 -Microglobulin in direct ELISAs and Western blots. (fishersci.com)
  • clarification needed] Diagnostic testing for multiple myeloma includes obtaining the β2 microglobulin level, for this level is an important prognostic indicator. (wikipedia.org)
  • Multiple myeloma accounts for approximately 1% of all cancers and 2% of all deaths from cancer. (encyclopedia.com)
  • In this continuing study, our new goal was to compare the diagnostic potential of beta-2-microglobulin ($2M) with that of six other tumor antigens for breast, ovarian, testicular and prostate cancers. (thefreedictionary.com)
  • β2 microglobulin was assayed using the N Latex β2 microglobulin assay, Siemens Diagnostics, IL. (cdc.gov)
  • B2M was assayed using the N Latex β2 microglobulin assay (Siemens Diagnostics). (cdc.gov)
  • In a linear regression model, the interaction term between estimated glomerular filtration rate categories and the inverse of β2 microglobulin was highly significant (p-value = 0.001). (up.ac.za)
  • The beta 2-Microglobulin Antibody (B2M / 961) [PerCP] has been validated for the following applications: Flow Cytometry, Immunohistochemistry-Paraffin. (vwr.com)
  • β2 microglobulin associates not only with the alpha chain of MHC class I molecules, but also with class I-like molecules such as CD1 and Qa. (wikipedia.org)
  • Immunoassay reagents intended to perform qualitative and/or quantitative analyses on a body fluid sample (e.g., serum) to determine the beta-2-microglobulin (B2M) protein. (optometricmanagement.com)
  • The authors conclude that low concentrations of beta-2- microglobulin and aminoaciduria are found in workers exposed to yellowcake. (cdc.gov)
  • The Beta-2 Microglobulin ELISA test is an enzyme immunoassay (EIA) for the measurement of Beta-2 Microglobulin in serum as an aid in the diagnosis of active rheumatoid arthritis and kidney disease. (rapidtest.com)
  • The Immulite 2000 Beta-2 Microglobulin assay is a solid phase, 2-site chemiluminescent enzyme-labeled immunometric assay. (testcatalog.org)