AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
beta 2-MicroglobulinBeta-GlobulinsAlpha-GlobulinsInterleukin-1betaAmyloidosisHistocompatibility Antigens Class IAmyloidTrypsin Inhibitor, Kunitz SoybeanReceptors, Adrenergic, betaIntegrin beta3HLA AntigensAcetylglucosaminidaseH-2 AntigensCadmium PoisoningNeopterinTransforming Growth Factor betaCell LineGenes, MHC Class IMultiple MyelomaMolecular Sequence DataRNA, MessengerCreatinineHLA-B27 AntigenHemodiafiltrationRenal DialysisIntegrin alpha5beta1Integrin beta4Cells, CulturedBase SequenceIntegrin alpha6beta4Integrin beta Chainsbeta 2-Glycoprotein IAmino Acid SequenceIntegrin alpha4beta1Interleukin-1Integrin alpha2beta1Receptors, Adrenergic, beta-2Protein ConformationMice, Inbred C57BLMajor Histocompatibility ComplexProteinuriaAntibodies, MonoclonalMacromolecular SubstancesRecombinant ProteinsHistocompatibility AntigensTransfectionHistocompatibility Antigen H-2DIntegrinsAntigens, CD29Integrin alpha6beta1Biological MarkersKidney TubulesCadmiumReceptors, Adrenergic, beta-1Models, MolecularKineticsPeptide FragmentsTime FactorsAntigens, SurfaceMice, KnockoutGene Expression RegulationProtein FoldingIntegrin alpha1beta1Tumor Cells, CulturedCalnexinKidney DiseasesKidney
beta 2-Microglobulin
An 11-kDa protein associated with the outer membrane of many cells including lymphocytes. It is the small subunit of the MHC class I molecule. Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. Beta 2-microglobulin is present in small amounts in serum, csf, and urine of normal people, and to a much greater degree in the urine and plasma of patients with tubular proteinemia, renal failure, or kidney transplants.
Beta-Globulins
Serum proteins with an electrophoretic mobility that falls between ALPHA-GLOBULINS and GAMMA-GLOBULINS.
Alpha-Globulins
Serum proteins that have the most rapid migration during ELECTROPHORESIS. This subgroup of globulins is divided into faster and slower alpha(1)- and alpha(2)-globulins.
Interleukin-1beta
An interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein. Proteolytic processing of the precursor form by CASPASE 1 results in release of the active form of interleukin-1beta from the membrane.
Amyloidosis
A group of sporadic, familial and/or inherited, degenerative, and infectious disease processes, linked by the common theme of abnormal protein folding and deposition of AMYLOID. As the amyloid deposits enlarge they displace normal tissue structures, causing disruption of function. Various signs and symptoms depend on the location and size of the deposits.
Histocompatibility Antigens Class I
Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during GRAFT REJECTION and restrict cell-mediated lysis of virus-infected cells.
Amyloid
A fibrous protein complex that consists of proteins folded into a specific cross beta-pleated sheet structure. This fibrillar structure has been found as an alternative folding pattern for a variety of functional proteins. Deposits of amyloid in the form of AMYLOID PLAQUES are associated with a variety of degenerative diseases. The amyloid structure has also been found in a number of functional proteins that are unrelated to disease.
Trypsin Inhibitor, Kunitz Soybean
A high-molecular-weight protein (approximately 22,500) containing 198 amino acid residues. It is a strong inhibitor of trypsin and human plasmin.
Receptors, Adrenergic, beta
One of two major pharmacologically defined classes of adrenergic receptors. The beta adrenergic receptors play an important role in regulating CARDIAC MUSCLE contraction, SMOOTH MUSCLE relaxation, and GLYCOGENOLYSIS.
Integrin beta3
An integrin beta subunit of approximately 85-kDa in size which has been found in INTEGRIN ALPHAIIB-containing and INTEGRIN ALPHAV-containing heterodimers. Integrin beta3 occurs as three alternatively spliced isoforms, designated beta3A-C.
HLA Antigens
Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.
Acetylglucosaminidase
A beta-N-Acetylhexosaminidase that catalyzes the hydrolysis of terminal, non-reducing 2-acetamido-2-deoxy-beta-glucose residues in chitobiose and higher analogs as well as in glycoproteins. Has been used widely in structural studies on bacterial cell walls and in the study of diseases such as MUCOLIPIDOSIS and various inflammatory disorders of muscle and connective tissue.
H-2 Antigens
The major group of transplantation antigens in the mouse.
Cadmium Poisoning
Poisoning occurring after exposure to cadmium compounds or fumes. It may cause gastrointestinal syndromes, anemia, or pneumonitis.
Neopterin
A pteridine derivative present in body fluids; elevated levels result from immune system activation, malignant disease, allograft rejection, and viral infections. (From Stedman, 26th ed) Neopterin also serves as a precursor in the biosynthesis of biopterin.
Transforming Growth Factor beta
A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.
Cell Line
Established cell cultures that have the potential to propagate indefinitely.
Genes, MHC Class I
Genetic loci in the vertebrate major histocompatibility complex which encode polymorphic characteristics not related to immune responsiveness or complement activity, e.g., B loci (chicken), DLA (dog), GPLA (guinea pig), H-2 (mouse), RT-1 (rat), HLA-A, -B, and -C class I genes of man.
Multiple Myeloma
A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Creatinine
HLA-B27 Antigen
A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*27 allele family.
Hemodiafiltration
The combination of hemodialysis and hemofiltration either simultaneously or sequentially. Convective transport (hemofiltration) may be better for removal of larger molecular weight substances and diffusive transport (hemodialysis) for smaller molecular weight solutes.
Renal Dialysis
Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, PERITONEAL DIALYSIS, and HEMODIAFILTRATION.
Integrin alpha5beta1
An integrin found in FIBROBLASTS; PLATELETS; MONOCYTES, and LYMPHOCYTES. Integrin alpha5beta1 is the classical receptor for FIBRONECTIN, but it also functions as a receptor for LAMININ and several other EXTRACELLULAR MATRIX PROTEINS.
Integrin beta4
Also known as CD104 antigen, this protein is distinguished from other beta integrins by its relatively long cytoplasmic domain (approximately 1000 amino acids vs. approximately 50). Five alternatively spliced isoforms have been described.
Cells, Cultured
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Base Sequence
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Integrin alpha6beta4
This intrgrin is a key component of HEMIDESMOSOMES and is required for their formation and maintenance in epithelial cells. Integrin alpha6beta4 is also found on thymocytes, fibroblasts, and Schwann cells, where it functions as a laminin receptor (RECEPTORS, LAMININ) and is involved in wound healing, cell migration, and tumor invasiveness.
Integrin beta Chains
Integrin beta chains combine with integrin alpha chains to form heterodimeric cell surface receptors. Integrins have traditionally been classified into functional groups based on the identity of one of three beta chains present in the heterodimer. The beta chain is necessary and sufficient for integrin-dependent signaling. Its short cytoplasmic tail contains sequences critical for inside-out signaling.
beta 2-Glycoprotein I
A 44-kDa highly glycosylated plasma protein that binds phospholipids including CARDIOLIPIN; APOLIPOPROTEIN E RECEPTOR; membrane phospholipids, and other anionic phospholipid-containing moieties. It plays a role in coagulation and apoptotic processes. Formerly known as apolipoprotein H, it is an autoantigen in patients with ANTIPHOSPHOLIPID ANTIBODIES.
Amino Acid Sequence
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Integrin alpha4beta1
Integrin alpha4beta1 is a FIBRONECTIN and VCAM-1 receptor present on LYMPHOCYTES; MONOCYTES; EOSINOPHILS; NK CELLS and thymocytes. It is involved in both cell-cell and cell- EXTRACELLULAR MATRIX adhesion and plays a role in INFLAMMATION, hematopoietic cell homing and immune function, and has been implicated in skeletal MYOGENESIS; NEURAL CREST migration and proliferation, lymphocyte maturation and morphogenesis of the PLACENTA and HEART.
Interleukin-1
A soluble factor produced by MONOCYTES; MACROPHAGES, and other cells which activates T-lymphocytes and potentiates their response to mitogens or antigens. Interleukin-1 is a general term refers to either of the two distinct proteins, INTERLEUKIN-1ALPHA and INTERLEUKIN-1BETA. The biological effects of IL-1 include the ability to replace macrophage requirements for T-cell activation.
Integrin alpha2beta1
An integrin found on fibroblasts, platelets, endothelial and epithelial cells, and lymphocytes where it functions as a receptor for COLLAGEN and LAMININ. Although originally referred to as the collagen receptor, it is one of several receptors for collagen. Ligand binding to integrin alpha2beta1 triggers a cascade of intracellular signaling, including activation of p38 MAP kinase.
Receptors, Adrenergic, beta-2
A subclass of beta-adrenergic receptors (RECEPTORS, ADRENERGIC, BETA). The adrenergic beta-2 receptors are more sensitive to EPINEPHRINE than to NOREPINEPHRINE and have a high affinity for the agonist TERBUTALINE. They are widespread, with clinically important roles in SKELETAL MUSCLE; LIVER; and vascular, bronchial, gastrointestinal, and genitourinary SMOOTH MUSCLE.
Protein Conformation
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
Mice, Inbred C57BL
Major Histocompatibility Complex
The genetic region which contains the loci of genes which determine the structure of the serologically defined (SD) and lymphocyte-defined (LD) TRANSPLANTATION ANTIGENS, genes which control the structure of the IMMUNE RESPONSE-ASSOCIATED ANTIGENS, HUMAN; the IMMUNE RESPONSE GENES which control the ability of an animal to respond immunologically to antigenic stimuli, and genes which determine the structure and/or level of the first four components of complement.
Proteinuria
The presence of proteins in the urine, an indicator of KIDNEY DISEASES.
Antibodies, Monoclonal
Antibodies produced by a single clone of cells.
Macromolecular Substances
Compounds and molecular complexes that consist of very large numbers of atoms and are generally over 500 kDa in size. In biological systems macromolecular substances usually can be visualized using ELECTRON MICROSCOPY and are distinguished from ORGANELLES by the lack of a membrane structure.
Recombinant Proteins
Proteins prepared by recombinant DNA technology.
Histocompatibility Antigens
A group of antigens that includes both the major and minor histocompatibility antigens. The former are genetically determined by the major histocompatibility complex. They determine tissue type for transplantation and cause allograft rejections. The latter are systems of allelic alloantigens that can cause weak transplant rejection.
Transfection
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
Histocompatibility Antigen H-2D
A component of the murine major histocompatibility complex class I family. It contains one Ig-like C1-type domain and functions in processing and presentation of exogenous peptide antigens to the immune system.
Integrins
A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors(RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation.
Antigens, CD29
Integrin beta-1 chains which are expressed as heterodimers that are noncovalently associated with specific alpha-chains of the CD49 family (CD49a-f). CD29 is expressed on resting and activated leukocytes and is a marker for all of the very late activation antigens on cells. (from: Barclay et al., The Leukocyte Antigen FactsBook, 1993, p164)
Integrin alpha6beta1
A cell surface receptor mediating cell adhesion to the EXTRACELLULAR MATRIX and to other cells via binding to LAMININ. It is involved in cell migration, embryonic development, leukocyte activation and tumor cell invasiveness. Integrin alpha6beta1 is the major laminin receptor on PLATELETS; LEUKOCYTES; and many EPITHELIAL CELLS, and ligand binding may activate a number of signal transduction pathways. Alternative splicing of the cytoplasmic domain of the alpha6 subunit (INTEGRIN ALPHA6) results in the formation of A and B isoforms of the heterodimer, which are expressed in a tissue-specific manner.
Biological Markers
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Kidney Tubules
Long convoluted tubules in the nephrons. They collect filtrate from blood passing through the KIDNEY GLOMERULUS and process this filtrate into URINE. Each renal tubule consists of a BOWMAN CAPSULE; PROXIMAL KIDNEY TUBULE; LOOP OF HENLE; DISTAL KIDNEY TUBULE; and KIDNEY COLLECTING DUCT leading to the central cavity of the kidney (KIDNEY PELVIS) that connects to the URETER.
Cadmium
An element with atomic symbol Cd, atomic number 48, and atomic weight 114. It is a metal and ingestion will lead to CADMIUM POISONING.
Receptors, Adrenergic, beta-1
A subclass of beta-adrenergic receptors (RECEPTORS, ADRENERGIC, BETA). The adrenergic beta-1 receptors are equally sensitive to EPINEPHRINE and NOREPINEPHRINE and bind the agonist DOBUTAMINE and the antagonist METOPROLOL with high affinity. They are found in the HEART, juxtaglomerular cells, and in the central and peripheral nervous systems.
Models, Molecular
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
Kinetics
The rate dynamics in chemical or physical systems.
Peptide Fragments
Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.
Time Factors
Elements of limited time intervals, contributing to particular results or situations.
Antigens, Surface
Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated.
Mice, Knockout
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Gene Expression Regulation
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
Protein Folding
Processes involved in the formation of TERTIARY PROTEIN STRUCTURE.
Integrin alpha1beta1
Integrin alpha1beta1 functions as a receptor for LAMININ and COLLAGEN. It is widely expressed during development, but in the adult is the predominant laminin receptor (RECEPTORS, LAMININ) in mature SMOOTH MUSCLE CELLS, where it is important for maintenance of the differentiated phenotype of these cells. Integrin alpha1beta1 is also found in LYMPHOCYTES and microvascular endothelial cells, and may play a role in angiogenesis. In SCHWANN CELLS and neural crest cells, it is involved in cell migration. Integrin alpha1beta1 is also known as VLA-1 and CD49a-CD29.
Tumor Cells, Cultured
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
Calnexin
A lectin found in ENDOPLASMIC RETICULUM membranes that binds to specific N-linked OLIGOSACCHARIDES found on newly synthesized proteins. It may play role in PROTEIN FOLDING or retention and degradation of misfolded proteins in the endoplasmic reticulum.
Kidney Diseases
Pathological processes of the KIDNEY or its component tissues.
Kidney
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.

A cytomegalovirus glycoprotein re-routes MHC class I complexes to lysosomes for degradation. (1/1648)

Mouse cytomegalovirus (MCMV) early gene expression interferes with the major histocompatibility complex class I (MHC class I) pathway of antigen presentation. Here we identify a 48 kDa type I transmembrane glycoprotein encoded by the MCMV early gene m06, which tightly binds to properly folded beta2-microglobulin (beta2m)-associated MHC class I molecules in the endoplasmic reticulum (ER). This association is mediated by the lumenal/transmembrane part of the protein. gp48-MHC class I complexes are transported out of the ER, pass the Golgi, but instead of being expressed on the cell surface, they are redirected to the endocytic route and rapidly degraded in a Lamp-1(+) compartment. As a result, m06-expressing cells are impaired in presenting antigenic peptides to CD8(+) T cells. The cytoplasmic tail of gp48 contains two di-leucine motifs. Mutation of the membrane-proximal di-leucine motif of gp48 restored surface expression of MHC class I, while mutation of the distal one had no effect. The results establish a novel viral mechanism for downregulation of MHC class I molecules by directly binding surface-destined MHC complexes and exploiting the cellular di-leucine sorting machinery for lysosomal degradation.  (+info)

Impaired lysosomal processing of beta2-microglobulin by infiltrating macrophages in dialysis amyloidosis. (2/1648)

BACKGROUND: Macrophages may participate in amyloid fibril formation by processing the protein precursor. Although this theory seems to apply for amyloidosis, in which proteolytic cleavage is a prerequisite for amyloid fibril formation, it has not been demonstrated for beta2-microglobulin (beta2m) amyloidosis. We aimed to establish the role played by macrophages in beta2m amyloidosis. METHODS: We used a double immunogold electron microscopy technique, including mouse antihuman CD68, rabbit antihuman beta2m, amyloid P component, and lysosome-associated membrane protein (LAMP-1) antibodies. Differential density labeling studies of beta2m and amyloid P component were performed extra- and intracellularly to assess protein processing by macrophages. RESULTS: The cells surrounding amyloid fibrils were found to be mostly CD68 positive, suggesting that they were of monocyte-macrophage lineage. Intracellular accumulation of amyloid fibrils was also observed; these fibrils were constantly surrounded by LAMP-1-linked gold particles, demonstrating that intracellular beta2m was almost exclusively lysosomal. The rough-surface endoplasmic reticulum was not labeled by beta2m antibody, suggesting that there was no active synthesis of beta2m by the cells. As a marker of endocytosis, protruded cytoplasmic processes in close relation with the intracellular accumulations of beta2m amyloid fibrils were observed. No difference in density labeling (extracellular vs. intracellular) was observed for beta2m, whereas intracellular P component labeling was significantly decreased. CONCLUSIONS: All of these data are strongly suggestive of phagocytosis and not synthesis of amyloid fibrils by macrophages. Further, they demonstrate an impaired lysosomal processing specific for beta2m, as other compounds of the amyloid fibrils (P component) are significantly cleared.  (+info)

Photophysical analysis of class I major histocompatibility complex protein assembly using a xanthene-derivatized beta2-microglobulin. (3/1648)

Spectral changes and a sixfold increase in the emission intensity were observed in the fluorescence of a single xanthene probe (Texas red) attached to beta2m-microglobulin (beta2m) upon assembly of beta2m into a ternary complex with mouse H-2Kd heavy chain and influenza nuclear protein peptide. Dissociation of the labeled beta2m from the ternary complex restored the probe's fluorescence and absorption spectra and reduced the emission intensity. Thus changes in xanthene probe fluorescence upon association/dissociation of the labeled beta2m molecule with/from the ternary complex provide a simple and convenient method for studying the assembly/dissociation mechanism of the class I major histocompatibility complex (MHC-I) encoded molecule. The photophysical changes in the probe can be accounted for by the oligomerization of free labeled beta2m molecules. The fluorescence at 610 nm is due to beta2m dimers, where the probes are significantly separated spatially so that their emission and excitation properties are close to those of xanthene monomers. Fluorescence around 630 nm is due to beta2m oligomers where xanthene probes interact. Minima in the steady-state excitation (550 nm) and emission (630 nm) anisotropy spectra correlate with the maxima of the high-order oligomer excitation and emission spectra, showing that their fluorescence is more depolarized. These photophysical features are explained by splitting of the first singlet excited state of interacting xanthene probes that can be modeled by exciton theory.  (+info)

Acute haemodynamic and proteinuric effects of prednisolone in patients with a nephrotic syndrome. (4/1648)

BACKGROUND: Administration of prednisolone causes an abrupt rise in proteinuria in patients with a nephrotic syndrome. METHODS: To clarify the mechanisms responsible for this increase in proteinuria we have performed a placebo controlled study in 26 patients with a nephrotic syndrome. Systemic and renal haemodynamics and urinary protein excretion were measured after prednisolone and after placebo. RESULTS: After i.v. administration of 125-150 mg prednisolone total proteinuria increased from 6.66+/-4.42 to 9.37+/-6.07 mg/min (P<0.001). By analysing the excretion of proteins with different charge and weight (albumin, transferrin, IgG, IgG4 and beta2-microglobulin) it became apparent that the increase of proteinuria was the result of a change in size selectivity rather than a change in glomerular charge selectivity or tubular protein reabsorption. Glomerular filtration rate rose from 83+/-34 ml to 95+/-43 ml/min (P<0.001) after 5 h, whereas effective renal plasma flow and endogenous creatinine clearance remained unchanged. As a result filtration fraction was increased, compatible with an increased glomerular pressure, which probably contributes to the size selectivity changes. Since corticosteroids affect both the renin-angiotensin system and renal prostaglandins, we have evaluated the effects of prednisolone on proteinuria after pretreatment with 3 months of the angiotensin-converting enzyme inhibitor lisinopril or after 2 weeks of the prostaglandin synthesis inhibitor indomethacin. Neither drug had any effect on prednisolone-induced increases of proteinuria. CONCLUSIONS: Prednisolone increases proteinuria by changing the size selective barrier of the glomerular capillary. Neither the renin-angiotensin axis nor prostaglandins seem to be involved in these effects of prednisolone on proteinuria.  (+info)

Stability of plasma levels of cytokines and soluble activation markers in patients with human immunodeficiency virus infection. (5/1648)

Cytokine and immune activation marker levels in plasma are valuable measurements of immune status and treatment effects in human immunodeficiency virus (HIV) infection and AIDS. Five populations representing various stages of disease were studied: controls, 2 AIDS groups with <50/mm3 CD4 cells, and 2 groups of HIV-positive subjects-1 with stable CD4 T cells (median, 545/mm3) and 1 with >100/mm3 CD4 cell decline in 1 year. Relatively stable levels of tumor necrosis factor (TNF)-alpha, soluble TNF receptor (R)II, soluble interleukin-2R, neopterin, and beta2-microglobulin (beta2M) were documented over 5-8 weeks in patients with AIDS and for 1-4 years in the other groups. beta2M was generally the most stable marker. Interferon-gamma levels, however, fluctuated substantially. Individuals, whether normal or HIV-positive, maintain characteristic plasma levels of cytokines and immune activation markers. Thus, documented changes, in excess of the variability observed in this study, are likely to be significant indicators of change in disease status or effects of therapy.  (+info)

Cyclooxygenase-2 expression is up-regulated in human pancreatic cancer. (6/1648)

A large body of evidence suggests that cyclooxygenase-2 (COX-2) is important in gastrointestinal cancer. The purpose of this study was to determine whether COX-2 was expressed in adenocarcinoma of the human pancreas. Quantitative reverse transcription-PCR, immunoblotting, and immunohistochemistry were used to assess the expression of COX-2 in pancreatic tissue. Levels of COX-2 mRNA were increased by >60-fold in pancreatic cancer compared to adjacent nontumorous tissue. COX-2 protein was present in 9 of 10 cases of adenocarcinoma of the pancreas but was undetectable in nontumorous pancreatic tissue. Immunohistochemical analysis showed that COX-2 was expressed in malignant epithelial cells. In cultured human pancreatic cancer cells, levels of COX-2 mRNA and protein were induced by treatment with tumor-promoting phorbol esters. Taken together, these results suggest that COX-2 may be a target for the prevention or treatment of pancreatic cancer.  (+info)

Soluble class I MHC with beta2-microglobulin covalently linked peptides: specific binding to a T cell hybridoma. (7/1648)

Soluble forms of the mouse MHC class I molecule, Dd, were produced in which the peptide binding groove was uniformly occupied by peptides attached via a covalent flexible peptide linker to the N terminus of the associated beta2-microglobulin. The MHC heavy chain and beta2-microglobulin were firmly associated, and the molecules displayed an Ab epitope requiring proper occupancy of the peptide binding groove. Soluble Dd containing a covalent version of a well-characterized Dd-binding peptide from HIV stimulated a T cell hybridoma specific for this combination. Furthermore, a tetravalent version of this molecule bound specifically with apparent high avidity to this hybridoma.  (+info)

Recognition of the major histocompatibility complex restriction element modulates CD8(+) T cell specificity and compensates for loss of T cell receptor contacts with the specific peptide. (8/1648)

Triggering of a T cell requires interaction between its specific receptor (TCR) and a peptide antigen presented by a self-major histocompatibility complex (MHC) molecule. TCR recognition of self-MHC by itself falls below the threshold of detection in most systems due to low affinity. To study this interaction, we have used a read-out system in which antigen-specific effector T cells are confronted with targets expressing high levels of MHC compared with the selecting and priming environment. More specifically, the system is based on CD8(+) T cells selected in an environment with subnormal levels of MHC class I in the absence of beta2-microglobulin. We observe that the MHC restriction element can trigger viral peptide-specific T cells independently of the peptide ligand, provided there is an increase in self-MHC density. Peptide-independent triggering required at least four times the natural in vivo level of MHC expression. Furthermore, recognition of the restriction element at expression levels below this threshold was still enough to compensate for lack of affinity to peptides carrying alanine substitutions in major TCR contact residues. Thus, the specificity in TCR recognition and T cell activation is fine tuned by the avidity for self-MHC, and TCR avidities for peptide and MHC may substitute for each other. These results demonstrate a functional role for TCR avidity for self-MHC in tuning of T cell specificity, and support a role for cross-reactivity on "self" during T cell selection and activation.  (+info)

Beta-2-microglobulin concentrations in pediatric human immunodeficiency virus infection<...Beta-2-microglobulin concentrations in pediatric human immunodeficiency virus infection<...
TY - JOUR. T1 - Beta-2-microglobulin concentrations in pediatric human immunodeficiency virus infection. AU - Ellaurie, Maadhava. AU - Rubinstein, Arye. PY - 1990/11. Y1 - 1990/11. N2 - Serum concentrations of beta-2-microglobulin (B2-M) were correlated with disease outcome in 40 children infected by the human immunodeficiency virus. Serum B2-M serum concentrations below 3.0 mg/100 ml or decreasing concentrations were indicative of a stable disease course but were also noted preterminally in lymphopenic children. Of 20 patients with B2-M concentrations above 3.0 mg/liter, 12 had a progressive disease course and 8 remained stable. In the latter 8 patients the B2-M values decreased with time. Elevated B2-M concentrations were also noted in infants younger than 1 year of age and denoted active human immunodeficiency virus infection. B2-M serum concentrations are a useful prognostic marker in human immunodeficiency virus-infected children.. AB - Serum concentrations of beta-2-microglobulin (B2-M) ...
https://einstein.pure.elsevier.com/en/publications/beta-2-microglobulin-concentrations-in-pediatric-human-immunodefi-2
Prothrombin, albumin and immunoglobulin A form covalent complexes with alpha1-microglobulin in human plasma - Lunds universitetProthrombin, albumin and immunoglobulin A form covalent complexes with alpha1-microglobulin in human plasma - Lunds universitet
Molecules containing the 33-kDa plasma protein alpha1-microglobulin were isolated from human plasma by anti-(alpha1-microglobulin) affinity chromatography. Five major bands could be seen after electrophoretic separation of the alpha1-microglobulin-containing proteins under native conditions. Immunoblotting demonstrated alpha1-microglobulin in all five bands. Two of these have been described previously: free alpha1-microglobulin and alpha1-microglobulin complexed with IgA (IgA x alpha1-microglobulin). The other three bands were identified as prothrombin alpha1-microglobulin, albumin x alpha1-microglobulin and dimeric alpha1-microglobulin. Prothrombin x alpha1-microglobulin were 1:2 and 1:1 complexes which carried approximately 1% of total alpha1-microglobulin, had molecular masses of about 145 kDa and 110 kDa upon SDS/PAGE and dissociated completely to free alpha1-microglobulin and prothrombin (72 kDa) when reducing agents were added, suggesting that the complexes were stabilized by disulfide ...
https://portal.research.lu.se/portal/sv/publications/prothrombin-albumin-and-immunoglobulin-a-form-covalent-complexes-with-alpha1microglobulin-in-human-plasma
Beta-2-microglobulin - What does Beta-2-microglobulin stand for? The Free DictionaryBeta-2-microglobulin - What does Beta-2-microglobulin stand for? The Free Dictionary
Looking for online definition of Beta-2-microglobulin or what Beta-2-microglobulin stands for? Beta-2-microglobulin is listed in the Worlds largest and most authoritative dictionary database of abbreviations and acronyms
http://acronyms.thefreedictionary.com/Beta-2-microglobulin
Studies on the Cytophilic Properties of Human β2 Microglobulin | The Journal of ImmunologyStudies on the Cytophilic Properties of Human β2 Microglobulin | The Journal of Immunology
Human β2microglobulin is cytophilic for mouse, rat, and to a lesser extent guinea pig lymphocytes and polymorphonuclear leukocytes but not for human, rabbit, chicken, frog, and turtle cells, nor for any mature erythrocytes tested. Mouse splenic lymphocytes bind 5- 7-fold more β2microglobulin than thymocytes although hydrocortisoneresistant thymocytes resemble spleen cells in this regard. The β2microglobulin binding by B and T cells in mouse spleen is similar. The structure responsible for β2 microglobulin binding to the surface of cells is distinct from the Fc receptor specific for aggregated IgG.. ...
http://www.jimmunol.org/content/114/3/997
β2-m amyloid fibrils induce apoptosis of HIG-82 cells | Open-iβ2-m amyloid fibrils induce apoptosis of HIG-82 cells | Open-i
β2-m amyloid fibrils induce apoptosis of HIG-82 cells as measured by the TUNEL assay.After HIG-82 cells were incubated with Hams F12 medium containing vehic
https://openi.nlm.nih.gov/detailedresult.php?img=PMC4589361_pone.0139330.g003&req=4
Comparison of 3 high-permeability dialysers]. - Semantic ScholarComparison of 3 high-permeability dialysers]. - Semantic Scholar
Three capillary dialyzers, with highly permeable membranes, have been compared for their capacity of epuration of blood urea nitrogen, creatinine, phosphorus, uric acid and beta 2 microglobulin, and for their respective protein losses. There were very little differences between the dialyzers for epuration of small uremic molecules, with no benefit due to high permeability membranes in comparison with conventional dialyzers. Protein losses may be important and have to be known. About beta 2 microglobulin, filtered quantities are not correlated to changes in serum levels, suggesting the presence of other mechanisms (adsorption on the membrane and generation during hemodialysis) which influence, together with epuration, perdialytic changes of serum beta 2 microglobulin concentrations.
https://www.semanticscholar.org/paper/Comparison-of-3-high-permeability-dialysers-Montagnac-Schillinger/a08631cd5feb8ab583d68f691a11b1deae250f9f
Beta-2 Microglobulin and Serum Cytokines x HAART - Full Text View - ClinicalTrials.govBeta-2 Microglobulin and Serum Cytokines x HAART - Full Text View - ClinicalTrials.gov
Objective: To assess the behavior of Beta-2 microglobulin and serum cytokines TNF-α, IFN-γ, IL-2, IL-4 and IL-10 as indicators of highly active antiretroviral therapy (HAART) failure Design: Cross-sectional study. Methods: Eighty-nine HIV-1+ patients and 20 normal individuals were divided into 4 groups: G1- 15 HIV-1+ individuals, previously untreated or without HAART for at least six months and CD4+ , 350 cells/mm3; G2- 31 HIV-1+ individuals undergoing HAART without virological therapeutic failure (TF), G3- 43 HIV-1+ individuals undergoing HAART with TF, and GC- 20 normal individuals who served as controls for serum cytokines. Demographic, clinical and HAART data were reviewed, and Beta-2 microglobulin, serum cytokines (TNF-α, IFN-γ, IL-2, IL-4 and IL-10), HIV-1 genotyping, plasma viral load and CD4+ and CD8+ lymphocytes tests were performed.. Key words: Beta-2 microglobulin, serum cytokines, HIV-1, resistance, HAART, therapeutic failure, genotyping. ...
https://clinicaltrials.gov/show/NCT00831207?order=691
Interleukin 7 induces preferential expansion of V beta 8.2+CD4-8- and V beta 8.2+CD4+8- murine thymocytes positively selected...Interleukin 7 induces preferential expansion of V beta 8.2+CD4-8- and V beta 8.2+CD4+8- murine thymocytes positively selected...
We analyzed the phenotype and V beta-T cell receptor (TCR) repertoire, together with interleukin 7 receptor (IL-7R) expression in unfractionated thymocytes stimulated in vitro with IL-7. This culture system results in a specific proliferation of mature thymocytes belonging to the CD3+CD4-, CD4+8-, and CD4-8+ subsets. IL-7 induced a preferential expansion of V beta 8.2+CD4-8- and V beta 8.2+CD4-8- thymocytes. This phenomenon is not observed in beta 2-microglobulin-deficient mice, showing that a fraction of CD4+8- thymocytes, enriched in V beta 8.2+ cells, is selected by class I molecules in normal mice, as are a large proportion of CD4-8- alpha beta TCR+ thymocytes. Our findings also establish that IL-7 plays a major role in the expansion of rare thymocyte subsets, which could exert important functions in inflammatory and immune responses. ...
http://jem.rupress.org/content/180/2/653
Anti Human Beta 2 Microglobulin Antibody, clone 2213 | Bio-RadAnti Human Beta 2 Microglobulin Antibody, clone 2213 | Bio-Rad
|strong|Mouse anti Human beta 2 microglobulin antibody, clone 2213|/strong| recognizes native human beta 2 microglobulin, a 119 amino acid component of MHC class I molecules present on all nucleated c…
https://www.bio-rad-antibodies.com/monoclonal/human-beta-2-microglobulin-antibody-2213-6240-0300.html
Faculty Collaboration Database - Updated analysis of CALGB (Alliance) 100104 assessing lenalidomide versus placebo maintenance...Faculty Collaboration Database - Updated analysis of CALGB (Alliance) 100104 assessing lenalidomide versus placebo maintenance...
BACKGROUND: In the CALGB (Alliance) 100104 study, lenalidomide versus placebo after autologous stem-cell transplantation (ASCT) was investigated for patients with newly diagnosed myeloma. That study showed improved time to progression and overall survival and an increase in second primary malignancies for lenalidomide at a median follow-up of 34 months. Here we report an updated intention-to-treat analysis of CALGB (Alliance) 100104 at a median follow-up of 91 months.. METHODS: Patients were eligible for this randomised, double-blind, placebo-controlled, phase 3 trial if they had symptomatic disease requiring treatment; had received, at most, two induction regimens; and had achieved stable disease or better in the first 100 days after ASCT. We randomly assigned patients to either lenalidomide or placebo groups using permuted block randomisation, with a fixed block size of six. Randomisation was stratified by three factors: normal or elevated β2 microglobulin concentration at registration ...
https://fcd.mcw.edu/?search/showPublication/id/755065
B2 Microglobulin Test, Beta 2 Microglobulin ELISA KitB2 Microglobulin Test, Beta 2 Microglobulin ELISA Kit
Active rheumatoid arthritis and kidney disease can be partially diagnosed with a B2 microglobulin test. Visit RapidTest for kit details. Order online.
http://www.rapidtest.com/index.php?i=Cancer-ELISA-kits&id=32&cat=9
beta-2 microglobulin Antibody - Antibody beta-2 microglobulin - Anti B2M
Mouse monoclonal Beta 2 Microglobulin Antibody. Tested Applications; Development of assay kits when used in conjunction with clone C21
http://www.immuquest.com/cancer-c52/tumor-suppressors-c65/beta-2-microglobulin-antibody-c21-p1134
anti-beta-2 Microglobulin antibody (AA 21-100) | Product No. ABIN2207569anti-beta-2 Microglobulin antibody (AA 21-100) | Product No. ABIN2207569
Mouse Monoclonal beta-2 Microglobulin antibody AA 21-100 for IC, FACS, IHC, ELISA, WB. Order anti-beta-2 Microglobulin antibody ABIN2207569.
https://www.antibodies-online.com/antibody/2207569/anti-beta-2-Microglobulin+B2M+AA+21-100+antibody/?utm_source=partner&utm_medium=chromocyte&utm_campaign=listing&utm_content=95&utm_term=ABIN2207569
Structure of an early native-like intermediate of β2-microglobulin amyloidogenesis. | SBRCStructure of an early native-like intermediate of β2-microglobulin amyloidogenesis. | SBRC
To investigate early intermediates of β2-microglobulin (β2m) amyloidogenesis, we solved the structure of β2m containing the amyloidogenic Pro32Gly mutation by X-ray crystallography. One nanobody (Nb24) that efficiently blocks fibril elongation was used as a chaperone to co-crystallize the Pro32Gly β2m monomer under physiological conditions. The complex of P32G β2m with Nb24 reveals a trans peptide bond at position 32 of this amyloidogenic variant, whereas Pro32 adopts the cis conformation in the wild-type monomer, indicating that the cis to trans isomerization at Pro32 plays a critical role in the early onset of β2m amyloid formation.. ...
http://sbrc.vub.ac.be/node/499
beta 2 Microglobulin (F21-21) - NBP1-28312 | acris-antibodies.com
beta 2 Microglobulin (F21-21), 0.25 mg. Like their mammalian counterparts, avian MHC Class I molecules (also known as B-F antigens) consist of a highly polymorphic alpha-chain (Mr approx.
https://www.acris-antibodies.com/antibodies/primary-antibodies/beta-2-microglobulin-f21-21-nbp1-28312.htm
HLA-F - ddPCR Probe - Digital PCR | PrimePCR | Bio-RadHLA-F - ddPCR Probe - Digital PCR | PrimePCR | Bio-Rad
Gene Information This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains this molecule is localized in the endoplasmic reticulum and Golgi apparatus with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site resulting in a shorter cytoplasmic domain. [provided by RefSeq Jul 2008]. ...
http://www.bio-rad.com/en-us/prime-pcr-assays/assay/dhsacpe5190676-primepcr-ddpcr-expression-probe-assay-hla-f-human
Mouse mAb anti- human beta 2 microglobulin (B2MG), Tracer (HRP Labeled), Clone D3A2 | esiservizi.com
Product Name: Mouse mAb anti- human beta 2 microglobulin (B2MG), Tracer (HRP Labeled), Clone D3A2Collection: AntibodySub Category: Matched Antibody
http://www.esiservizi.com/2017/09/15/Mouse-mAb-anti-human-beta-2-microglobulin-B2MG-Tracer-HRP-Labeled-Clone-D3A2/
beta 2 mikroglobulin u serumu
beta 2 microglobulin - General Practice Notebook, Beta-2 Microglobulin Kidney Disease - Lab Tests Online-UK, Beta-2 Microglobulin - an overview | ScienceDirect Topics, Beta 2-mikroglobulin u krvi i urinu | Kompetentno o , Beta2-Microglobulin: Reference Range, Interpretation
http://www.paperbomb.com/meds2/1/index.php?id=77
Gentaur Molecular :Exbio \ beta2 microglobulin \ 11-237-C100Gentaur Molecular :Exbio \ beta2 microglobulin \ 11-237-C100
Gentaur molecular products has all kinds of products like :search , Exbio \ beta2_microglobulin \ 11-237-C100 for more molecular products just contact us
http://www.antibody-antibodies.com/product_det.php?id=207068&supplier=search&name=beta2_microglobulin
Beta-2 Microglobulin Tumor MarkerBeta-2 Microglobulin Tumor Marker
Beta-2 microglobulin (B2M) is a protein shed by cells into the blood, including tumor cells. The B2M test can be used as a tumor marker for some people with blood cell cancers (multiple myeloma, lymphoma) to give information about their likely prognosis.
https://labtestsonline.org/tests/beta-2-microglobulin-tumor-marker
Gentaur Molecular :Assaypro \ Alpha 1 Microglobulin, anti human Species Human Format Biotin IgG Host Rabbit Polyclonal...Gentaur Molecular :Assaypro \ Alpha 1 Microglobulin, anti human Species Human Format Biotin IgG Host Rabbit Polyclonal...
Gentaur molecular products has all kinds of products like :search , Assaypro \ Alpha_1_ Microglobulin, anti_human Species Human Format Biotin_IgG Host Rabbit Polyclonal antibody \ 12051-05025 for more molecular products just contact us
http://www.antibody-antibodies.com/product_det.php?id=1056269&supplier=search&name=Alpha_1_%20Microglobulin,%20anti_human%20Species%20%20Human%20Format%20%20Biotin_IgG%20Host%20%20Rabbit%20Polyclonal%20antibody
alpha 1-Microglobulin Antibody (3F1) [PE] (H00000259-M01PE): Novus Biologicalsalpha 1-Microglobulin Antibody (3F1) [PE] (H00000259-M01PE): Novus Biologicals
Mouse Monoclonal Anti-alpha 1-Microglobulin Antibody (3F1) [PE]. Validated: WB, ELISA, ICC/IF, IHC, IHC-P. Tested Reactivity: Human. 100% Guaranteed.
https://www.novusbio.com/products/alpha-1-microglobulin-antibody-3f1_h00000259-m01pe
Anti-Alpha 1 microglobulin antibody [BN11.10] (ab18513)Anti-Alpha 1 microglobulin antibody [BN11.10] (ab18513)
Mouse monoclonal Alpha 1 microglobulin antibody [BN11.10] validated for WB, IP, ELISA, IHC, RIA, Other and tested in Human and Rat. Referenced in 1…
http://www.abcam.com/alpha-1-microglobulin-antibody-bn1110-ab18513.html
β2-MICROGLOBULIN BİOSİSTEM SAĞLIK ÜRÜNLERİ LTD.ŞTİ., Kan sayım cihazı - Hemogram - hematoloji - kan sayımıβ2-MICROGLOBULIN BİOSİSTEM SAĞLIK ÜRÜNLERİ LTD.ŞTİ., Kan sayım cihazı - Hemogram - hematoloji - kan sayımı
β2-MICROGLOBULIN BİOSİSTEM SAĞLIK ÜRÜNLERİ LTD.ŞTİ., İnsan yada farklı veterinerlik uygulamaları için kullanıcı dostu gelişmiş hematoloji sistemleri, kan sayım sistemleri, kan sayım cihazları
http://biosistem.com.tr/4_20110712024129_%CE%B22-MICROGLOBULIN
Human epithelial-type ovarian tumour marker beta-2-microglobulin is regulated by the TGF-β signaling pathway | Journal of...Human epithelial-type ovarian tumour marker beta-2-microglobulin is regulated by the TGF-β signaling pathway | Journal of...
Beta-2-microglobulin (B2M), a light chain subunit of the major histocompatibility complex (MHC) class I complex, has been implicated in tumorigenesis. However, whether it is expressed in different epithelial-type ovarian tumours remains unknown. This study was performed to examine the expression of B2M in different histopathological types of ovarian tumours, to explore the function of B2M in ovarian cancer (OC) cells and to investigate the mechanisms underlying the regulation of B2M by the TGF-β signaling pathway. B2M expression in normal ovarian tissues and epithelia-type ovarian tumours was detected by immunohistochemistry and Western blot, followed by the analysis of association with clinical features. OC cells were transfected with B2M-siRNA and cell proliferation, migration and invasion were determined by WST-1 assay, wound healing assay and Transwell invasion assay, respectively. The regulation of B2M by the TGF-β signaling pathway in OC cells was examined by Western blot, ELISA and qRT-PCR. We
https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-016-0832-x
How to make serum for tissue culture?How to make serum for tissue culture?
Hi, folks, Im trolling this through sci.med in the hopes of picking up some M.D. readers who have hematology experiemce but who dont ordinar- ily read the bionet newsgroups. Similarly for bionet.immunology. How- ever, I have set the followups back to bionet.cellbiol, which I think is the most appropriate newsgroup for this rather technical discussion. Ive run into an interesting problem. I am working with an an- tibody to the class I MHC molecule. I am studying class I MHC in a species of New World Monkey; some individuals react to this antibody, and some of them do not. The antibody recognizes an epitope that spans across the class I heavy chain and beta-2 microglobulin. I have identi- fied an amino acid polymorphism in beta-2m that is responsible for the antibody reactivity. You may recall that class I heavy chains are membrane-anchored molecules, but beta-2m is not. So class I heavy chains can lose their endogenous beta-2m in cell culture, and pick up the beta-2m from the cul- ture medium. ...
http://www.bio.net/bionet/mm/cellbiol/1998-February/008223.html
Multiple defects in antigen presentation and T cell development by mice expressing cytoplasmic tail-truncated CD1dMultiple defects in antigen presentation and T cell development by mice expressing cytoplasmic tail-truncated CD1d
For members of the CD1 family of beta(2)-microglobulin-associated lipid-presenting molecules, tyrosine-based motifs in the cytoplasmic tail and invariant chain (Ii) govern glycoprotein trafficking through endosomal compartments. Little is known about the intracellular pathways of CD1 trafficking and …
https://pubmed.ncbi.nlm.nih.gov/11731798/?dopt=Abstract
RCSB PDB - 2D4F: The Crystal Structure of human beta2-microglobulinRCSB PDB - 2D4F: The Crystal Structure of human beta2-microglobulin
As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
https://www.rcsb.org/structure/2d4f
The Driving Parts of E/M Level Selection: Part 1 - AAPC Knowledge CenterThe Driving Parts of E/M Level Selection: Part 1 - AAPC Knowledge Center
Part 1 of this three-part series provides an in-depth look at the history component. By Raemarie Jimenez, CPC, CPC-I, CANPC, CRHC Although evaluation and
https://www.aapc.com/blog/24883-the-driving-parts-of-em-level-selection/
Alteration within a discrete region of the H-2Ld alpha 1 helix...Alteration within a discrete region of the H-2Ld alpha 1 helix...
Alteration within a discrete region of the H-2Ld alpha 1 helix upon association with human beta 2 microglobulin.: The utilization of the beta 2-microglobulin (B
https://www.mysciencework.com/publication/show/alteration-within-discrete-region-h-2ld-alpha-1-helix-upon-association-human-beta-2-microglobulin-bc1655bd
Beta 2 microglobulin - GENNOVABeta 2 microglobulin - GENNOVA
This website uses cookies to improve your experience while you navigate through the website. Out of these cookies, the cookies that are categorized as necessary are stored on your browser as they are as essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may have an effect on your browsing experience ...
https://gennovascientific.com/product/beta-2-microglobulin-2/
RCPA - Beta-2-microglobulin CSFRCPA - Beta-2-microglobulin CSF
Increased CSF levels, relative to serum levels, are found with CNS involvement in Acute lymphoblastic leukaemia and Lymphoma (non-Hodgkin).. Increased levels are seen with severe neurological impairment in Multiple sclerosis.. ...
https://www.rcpa.edu.au/Library/Practising-Pathology/RCPA-Manual/Items/Pathology-Tests/B/Beta-2-microglobulin-CSF
CD4+CD8- T cells are the effector cells in disease pathogenesis in the scurfy (sf) mouse. | The Journal of ImmunologyCD4+CD8- T cells are the effector cells in disease pathogenesis in the scurfy (sf) mouse. | The Journal of Immunology
Mice hemizygous for the X-linked mutation, scurfy (sf), exhibit a fatal lymphoreticular disease that is mediated by T lymphocytes. To evaluate the respective roles of CD4 or CD8 single positive T cells in scurfy disease, neonates were treated with mAbs directed against the CD4 or CD8 molecules. Whereas mice treated with an anti-CD8 Ab developed lesions and succumbed to disease at the same time (17 days) as their untreated scurfy littermates, mice treated with an anti-CD4 Ab lived up to 11 wk before developing scurfy disease. To insure a more complete elimination of the T cell subsets, the scurfy mutation was bred onto beta 2-microglobulin (beta 2m)-deficient (CD8-less) and CD4-deficient transgenic mouse lines. Whereas there was little moderation of disease in beta 2m-deficient scurfy mice, CD4-deficient scurfy mice had markedly decreased scurfy lesions and a prolonged life span, similar to that of anti-CD4-treated sf/Y mice. Additionally, scurfy disease was transplanted into H-2-compatible nude ...
http://www.jimmunol.org/content/153/8/3764.long
What pill is round with a m on one side an a 23 on the other side-Blood Pressure Questions answered
Answers for What pill is round with a m on one side an a 23 on the other side:A round pill with a 23 on one side and an m on the other is Amlodipine. It is used with or without other medications to treat high blood pressure (hypertension).
http://www.themedicalquestions.com/bp/what-pill-is-round-with-a-m-on-one-side-an-a-23-on-the-other-side.html
SKI M-FREE 108 + BINDINGS SPX 12 DUAL B120 CONCRETE/YELLOW - Easy GlissSKI M-FREE 108 + BINDINGS SPX 12 DUAL B120 CONCRETE/YELLOW - Easy Gliss
This progressive freeride ski is an ode to freedom and a very lightweight toy for forays between the trees or fast-paced descents in... Payer en 3 fois sans frais à partir de 149€
https://www.easy-gliss.com/en/ski/alpine-skiing/material/ski-sets-bindings/ski-m-free-108-bindings-spx-12-dual-b120-concrete-yellow-3607683545445-9170.html
ivf-infertility.com | Due Winter 2012ivf-infertility.com | Due Winter 2012
First of all I want to thank each and everyone of you ladies for being there for me through my darkest hours. The last 48 hours have been a rollercoaster unlike any other. I went from feeling at my highest thinking I was carrying twins to most likely loosing both. I will keep this a bit short as I am exhausted from these past few days. Not physically but emotionally and mentally exhausted. I went today for the repeat Beta and unfortunately it had gone down to the 700s. My RE and i discussed it and i will continue on my meds until Monday. This way we can feel comfertable that we did not stop the meds too early. Unfortunately, I know in my heart that the Beta will be lower on Monday meaning that I did in fact have a miscarriage of both. My RE is certain that both embabies attached because of the elevated Beta levels. My RE is baffled as we are as we are. With a first Beta of 275 and then a second Beta of 1,513 we were sure that all was progressing. But we were wrong. My RE is not optimistic at ...
http://www.ivf-infertility.com/phpBB3/viewtopic.php?f=6&t=23795&sid=96a4eb79633c88f39d8ce5a4b0ff47ae&start=180
0.007702</PDBx:fract transf...0.007702</PDBx:fract transf...
The biological assembly is a heterotrimeric complex consisting of one HLA-B*2709 (heavy) chain, one beta-2-microglobulin (light) chain and one decameric model peptide s10R ...
https://files.rcsb.org/view/1JGD-noatom.xml
PAA260Hu01 | β2-微球蛋白(b2M)多克隆抗体 | Homo sapiens (Human，人) USCN(武汉优尔生商贸有限公司)PAA260Hu01 | β2-微球蛋白(b2M)多克隆抗体 | Homo sapiens (Human，人) USCN(武汉优尔生商贸有限公司)
PAA260Hu01, Polyclonal Antibody to Beta-2-Microglobulin (b2M), β2-微球蛋白(b2M)多克隆抗体, BMG; B2MG | 仅供体外研究使用，不用于临床诊断！请索取进口关税税单及报关单！
http://www.uscnk.cn/uscn/Antibody-to-Human-Beta-2-Microglobulin
Vonage Every time I call Im on hold forever. I have to use my cell because my Vonage line
Vonage Every time I call I m on hold forever. I have to use my cell because my Vonage line doesn t work. Duh that s why I m calling support. Anyway most of the time my battery goes dead because I m on hold for so long. Well folks I solved the problem. I swi
http://www.vonage-forum.com/Every_time_I_call_I_m_on_hold_forever_I_have_to_use_my_cell_because_my_Vonage_line-post-15241.html
Digestion Center A-Z List - M on MedicineNet.comDigestion Center A-Z List - M on MedicineNet.com
Digestion information covering the digestion system and related diseases, procedures and tests, medications, and treatments. Produced by doctors.
https://www.medicinenet.com/script/main/alphaidx.asp?p=m_2
Optimising logistic processes with rapidM2M on Environmental XPRTOptimising logistic processes with rapidM2M on Environmental XPRT
Article Optimising logistic processes with rapidM2M. When delivering products, it is crucial to keep an eye on GPS positions, delivery dates as well as the quality of the products. Machine-to-Machine technology enables you to do so from your office d...
https://www.environmental-expert.com/articles/optimising-logistic-processes-with-rapidm2m-445877
M on medicalmed.usM on medicalmed.us
All materials presented on the website have exclusively help and fact-finding character and cannot be considered as the method of treatment appointed by the doctor or sufficient consultation.. Administration of the website and authors of articles do not bear responsibility for any losses and effects which can arise when using materials of the website.. ...
https://medicalmed.us/m-symptoms.htm
3M Company (NYSE:MMM) - UPDATE: Jefferies & Company Cuts PT to $107 on 3M on Cautious Outlook | Benzinga3M Company (NYSE:MMM) - UPDATE: Jefferies & Company Cuts PT to $107 on 3M on Cautious Outlook | Benzinga
Jefferies & Company reiterated its Buy rating on 3M (NYSE: MMM) but lowered its price target from $110 to $107. Jefferies & Company noted, Given ...
https://www.benzinga.com/analyst-ratings/analyst-color/12/10/3022523/update-jefferies-company-cuts-pt-to-107-on-3m-on-cautiou
17516 LEXUS IS200 BTCC BODY (200mm)17516 LEXUS IS200 BTCC BODY (200mm)
HPI ylpeänä esittelee LEXUS IS200 BTC KORIN touring-autihin! Kirkkaan korin mukana seuraa musta 3D siipisarja. Tämä on aidon HPI:n 2005 sponsoroiman BTTC auton kopio.. Koriin on kopioitu kaikki pienet yksityiskohdat esikuvasta, jotta autostasi tulisi mahdollisimman realistisen näköinen. Korin mukana seuraa viralliset HPI Racing with Friends Reunited -teamin tarrat. 200 mm kori sopii melkein kaikkiin polttomoottorikäyttöisiin touring-autoihin ja moniin 190 mm leveisiin sähkökäyttöisiin touring-autoihin käytettässä vanteita 6 mm offsetillä tai vanteenleventäjiä. ...
http://www.hpiracing.com/fi/part/17516
Flavonoid Complex, flavonoidi toidulisandFlavonoid Complex, flavonoidi toidulisand
Olen NeoLife edasimüüja Eestis üle 20.aasta ja saanud palju häid kogemusi. Minu kõige suurem rõõm on see, et lapselaps on olnud terve ja saanud käia lasteaias. Saavutasime tugeva immuunsuse tänu toitumise parandamisele ja NeoLife toidulisandite tarbimisele. Leia mind FBs ja www.toitumisnoustaja.com ...
https://enemagi.neolifeshop.com/p/toidulisandid/sihtotstarbelised-lahendused/flavonoid-complex-flavonoidi-toidulisand-1393.html
Flavonoid Complex, flavonoidi toidulisandFlavonoid Complex, flavonoidi toidulisand
Olen NeoLife edasimüüja Eestis üle 20.aasta ja saanud palju häid kogemusi. Minu kõige suurem rõõm on see, et lapselaps on olnud terve ja saanud käia lasteaias. Saavutasime tugeva immuunsuse tänu toitumise parandamisele ja NeoLife toidulisandite tarbimisele. Leia mind FBs ja www.toitumisnoustaja.com ...
https://enemagi.neolifeshop.com/p/suplementy-ywnociowe/flavonoid-complex-1393.html
Articles MArticles M
Articles M on Peacefulmind.com | Its important that you develop effective strategies for managing your time to balance the conflicting demands of time for…
http://www.peacefulmind.com/category/archive-articles/articles-m/
Interferons up-regulate with different potency HLA class I antigen expression in M14 human melanoma cell line. Possible...
TY - JOUR. T1 - Interferons up-regulate with different potency HLA class I antigen expression in M14 human melanoma cell line. Possible interaction with glucocorticoid hormones. AU - Lanza, Lorella. AU - Peirano, Lorenza. AU - Bosco, Ornella. AU - Contini, Paola. AU - Filaci, Gilberto. AU - Setti, Maurizio. AU - Puppo, Francesco. AU - Indiveri, Francesco. AU - Scudeletti, Marco. PY - 1995/1. Y1 - 1995/1. N2 - The relative potency of interferon α (IFNα), interferon β (IFNβ), and interferon γ (IFNγ) in inducing the expression of HLA class I antigens, as well as their capacity to counteract the inhibition induced by glucocorticoid hormones on HLA class I antigen expression, were analysed in the human melanoma cell line M14, both at membrane and at mRNA level. The data obtained indicate that (a) IFN enhance with different potency (IFNγ,IFNβ,IFNα) the expression of HLA class I antigens in M14 cells, (b) prednisone inhibits HLA class I antigen expresion, (c) glucocorticoid hormones, when ...
https://moh-it.pure.elsevier.com/en/publications/interferons-up-regulate-with-different-potency-hla-class-i-antige
Persistent fever and destructive arthritis caused by dialysis-related amyloidosis<...
TY - JOUR. T1 - Persistent fever and destructive arthritis caused by dialysis-related amyloidosis. AU - Matsumoto, Kotaro. AU - Kikuchi, Jun. AU - Kaneko, Yuko. AU - Yasuoka, Hidekata. AU - Suzuki, Kazuko. AU - Tokuyama, Hirobumi. AU - Kameyama, Kaori. AU - Yamaoka, Kunihiro. AU - Takeuchi, Tsutomu. PY - 2018/1/1. Y1 - 2018/1/1. N2 - Rationale: Dialysis-related amyloidosis (DRA) can present rheumatic manifestations in patients on long-term hemodialysis. Typical articular symptoms with DRA involve carpal-tunnel syndrome, effusion in large joints, spondyloarthropathy, or cystic bone lesions, which are usually with non-inflammatory processes. Patient concerns: A 64-year-old man on hemodialysis for ,30 years was admitted because of intermittent fever, polyarthritis, and elevated serum C-reactive protein (CRP) level, which was continuous for 2 years. Several antibiotics were ineffective for 3 months before his admission. On physical examination, joint swelling was observed at bilateral wrists, knees, ...
https://keio.pure.elsevier.com/en/publications/persistent-fever-and-destructive-arthritis-caused-by-dialysis-rel
High-resolution characterization of structural changes involved in prion diseases and dialysis-related amyloidosis ...High-resolution characterization of structural changes involved in prion diseases and dialysis-related amyloidosis ...
Protein aggregation is the cause of several human diseases such as diabetes mellitus type 2, Parkinson s disease, Alzheimer s disease, Huntington s disease, spongiform encephalopathies, congestive heart failure or dialysis-related amyloidosis. All of these disorders result from protein misfolding which leads to fibrillization and deposition of amyloid plaques in different parts of the body.Due to high molecular weight of the amyloid fibrils and intrinsic heterogeneity of the intermediate states, protein aggregation is a very challenging field of study for the structural biologist. However, nuclear magnetic resonance (NMR) provides a unique possibility to investigate aggregation at all stages, from the monomer to the fibrils.In this work, structural changes involved in prion diseases and dialysis-related amyloidosis are investigated with the help of various NMR techniques.Prion diseases are caused by the aggregation of the natively α-helical prion protein PrPC into its pathological β-sheet-rich ...
https://ediss.uni-goettingen.de/handle/11858/00-1735-0000-0006-AD78-D
Uncovering possible role of polyphosphate in dialysis-related amyloidosis - Family Medicine NewsUncovering possible role of polyphosphate in dialysis-related amyloidosis - Family Medicine News
Long-term dialysis treatment is tough on the body in many ways, but one of the most serious complications is dialysis-related amyloidosis, a disease characterized by abnormal buildup of protein aggregates-called amyloid fibrils-in joints, tissues and organs.. Although there is no cure, recent research by Osaka University researchers sheds light on how amyloid fibrils form and aggregate, thereby allowing the identification of new therapeutic and preventive avenues to further improve the lives of sufferers.. In a study published in Proceedings of the National Academy of Sciences, Osaka University researchers have identified that polyphosphate (polyP), which is a naturally occurring polymer in the body and a food and drink additive, induces the formation of amyloid fibrils from β2 microglobulin proteins.. PolyPs play an important role in life as storage of phosphorous. When kidney function is normal, β2 microglobulin serum blood levels remain low. However, β2 microglobulin are not efficiently ...
http://familymednews.com/health-problems/uncovering-possible-role-of-polyphosphate-in-dialysis-related-amyloidosis/
Beta2 microglobulin | definition of beta2 microglobulin by Medical dictionaryBeta2 microglobulin | definition of beta2 microglobulin by Medical dictionary
Looking for online definition of beta2 microglobulin in the Medical Dictionary? beta2 microglobulin explanation free. What is beta2 microglobulin? Meaning of beta2 microglobulin medical term. What does beta2 microglobulin mean?
http://medical-dictionary.thefreedictionary.com/beta2+microglobulin
The Pathway of Us11-Dependent Degradation of Mhc Class I Heavy Chains Involves a Ubiquitin-Conjugated Intermediate | JCBThe Pathway of Us11-Dependent Degradation of Mhc Class I Heavy Chains Involves a Ubiquitin-Conjugated Intermediate | JCB
Mhc class I molecules display intracellularly derived peptides on the surface of almost all nucleated mammalian cells for recognition by the immune system. MHC class I heavy chain, which contains the peptide binding site, is a classical type I transmembrane protein with a large luminal/extracellular domain and a short cytosolic tail. The heavy chain enters the secretory pathway via the ER translocon, a channel whose major component is Sec61. The light chain β2 microglobulin (β2m)1 and the peptide associate with the heavy chain after it has been inserted into the ER membrane, and the complex is then transported, via the Golgi, to the plasma membrane. In humans, the MHC class I heavy chain is a 43-kD protein that contains a single N-linked glycan.. Human cytomegalovirus (HCMV) evades detection by the immune system by targeting MHC class I heavy chains for destruction soon after they have been synthesized. The HCMV proteins responsible for MHC class I heavy chain destruction are US11 and US2 ...
http://jcb.rupress.org/content/147/1/45
A common beta-sheet architecture underlies in vitro and in vivo beta(2)-microglobulin amyloid fibrils - White Rose Research...A common beta-sheet architecture underlies in vitro and in vivo beta(2)-microglobulin amyloid fibrils - White Rose Research...
Misfolding and aggregation of normally soluble proteins into amyloid fibrils and their deposition and accumulation underlies a variety of clinically significant diseases. Fibrillar aggregates with amyloid-like properties can also be generated in vitro from pure proteins and peptides, including those not known to be associated with amyloidosis. Whereas biophysical studies of amyloid-like fibrils formed in vitro have provided important insights into the molecular mechanisms of amyloid generation and the structural properties of the fibrils formed, amyloidogenic proteins are typically exposed to mild or more extreme denaturing conditions to induce rapid fibril formation in vitro. Whether the structure of the resulting assemblies is representative of their natural in vivo counterparts, thus, remains a fundamental unresolved issue. Here we show using Fourier transform infrared spectroscopy that amyloid-like fibrils formed in vitro from natively folded or unfolded β2-microglobulin (the protein ...
http://eprints.whiterose.ac.uk/4085/
Factors influencing serum neopterin and beta 2-microglobulin levels in a healthy diverse population | RTIFactors influencing serum neopterin and beta 2-microglobulin levels in a healthy diverse population | RTI
Sera and questionnaire data from a population-based random sample of healthy adults was used to evaluate factors influencing neopterin and beta 2-microglobulin (beta 2m) values. Both neopterin and beta 2m levels increased with age and were higher among white than blacks (mean values for whites and blacks: neopterin, 5.06 vs 4.49 nmol/L; beta 2m, 1.36 vs 1.28 mg/L). Gender
https://www.rti.org/publication/factors-influencing-serum-neopterin-and-beta-2-microglobulin-levels-healthy-diverse
Lactoferrin, lysozyme, and beta 2-microglobulin in cerebrospinal fluid. Elevated levels in patients with acute cerebrovascular...Lactoferrin, lysozyme, and beta 2-microglobulin in cerebrospinal fluid. Elevated levels in patients with acute cerebrovascular...
Serial determinations of beta 2-microglobulin, lactoferrin and lysozyme in CSF were performed in 14 patients with acute cerebrovascular lesions. Marked elevations were noted in patients with cerebral bleeding or hemorrhagic infarction. Patients with infarction without signs of bleeding or with cerebrovascular lesions undetectable by computed tomography also had an increase in these proteins. The increases in CSF of beta 2-microglobulin, lactoferrin and lysozyme could not be explained by a damaged blood-brain barrier but was believed to be a local product of the central nervous system. Peak levels of lactoferrin and lysozyme were noted on day 2-3 after onset of symptoms. Lactoferrin then declined while lysozyme remained elevated for another few days. beta 2-microglobulin gradually increased reaching peak levels on day 4-5 and remained elevated even 2 weeks after the onset of symptoms. We suggest that the increases of lactoferrin, lysozyme and beta 2-microglobulin reflect various inflammatory ...
http://stroke.ahajournals.org/content/12/1/40
Genome-wide association study identified the human leukocyte antigen region as a novel locus for plasma beta-2 microglobulin<...
TY - JOUR. T1 - Genome-wide association study identified the human leukocyte antigen region as a novel locus for plasma beta-2 microglobulin. AU - Tin, Adrienne. AU - Astor, Brad C.. AU - Boerwinkle, Eric. AU - Hoogeveen, Ron C.. AU - Coresh, Josef. AU - Kao, Wen Hong Linda. PY - 2013/6. Y1 - 2013/6. N2 - Beta-2 microglobulin (B2M) is a component of the major histocompatibility complex (MHC) class I molecule and has been studied as a biomarker of kidney function, cardiovascular diseases and mortality. Little is known about the genes influencing its levels directly or through glomerular filtration rate (GFR). We conducted a genome-wide association study of plasma B2M levels in 6738 European Americans from the Atherosclerosis Risk in Communities study to identify novel loci for B2M and assessed its association with known estimated GFR (eGFR) loci. We identified 2 genome-wide significant loci. One was in the human leukocyte antigen (HLA) region on chromosome 6 (lowest p value = 1.8 × 10 -23 for ...
https://jhu.pure.elsevier.com/en/publications/genome-wide-association-study-identified-the-human-leukocyte-anti-4
Amyloidosis and Kidney Disease
Normal kidneys filter and remove excess small proteins from the blood, thus keeping blood levels normal. When the kidneys dont work properly, as in patients receiving dialysis, one type of small protein calle beta-2-microglobulin builds up in the blood. When this occurs, beta-2-microglobulin molecules may join together, like the links of a chain, forming a few very large molecules from many smaller ones. These large molecules can form deposits and eventually damage the surrounding tissues and cause great discomfort. This condition is called dialysis-related amyloidosis (DRA). DRA is relatively common in patients, especially older adults, who have been on hemodialysis for more than 5 years. Hemodialysis membranes that have been used for many years dont effectively remove the large, complex beta-2-microglobulin proteins from the bloodstream. Newer hemodialysis membranes, as well as peritoneal dialysis, remove beta-2-microglobulin more effectively, but not enough to keep blood levels normal. As a ...
http://www.kruf.org.uk/kidney/amyloidosis.html
Leukocyte-Derived Interferon (Alpha) in Human Breast CarcinomaThe American Cancer Society Phase II Trial | Annals of Internal...Leukocyte-Derived Interferon (Alpha) in Human Breast CarcinomaThe American Cancer Society Phase II Trial | Annals of Internal...
A multi-institutional trials program was initiated to define the effects of interferons in disseminated human breast carcinoma. Interferon alpha, prepared from buffy coats, was administered intramuscularly at 3 ×106 U daily for an initial period of 28 days. Of 23 patients who entered the program, five had an objective partial response of 92 days mean duration at diverse sites of involvement. Patients who responded were significantly older (p = 0.05) than nonresponders. Dose escalation in eight patients did not result in any clear evidence of additional responses. Major toxicities were fatigue, anorexia with weight loss, and reversible leukopenia (less than 3.5 ×109 leukocytes/L in 16 patients). Natural killer cell and antibody-dependent cell-mediated cytotoxicity were significantly (p , 0.05) enhanced 48 hours after interferon administration began but subsequently declined despite continued therapy. Serum β2microglobulin concentration increased on day 15 (p , 0.05) and remained significantly ...
http://annals.org/aim/article-abstract/695714/leukocyte-derived-interferon-alpha-human-breast-carcinoma-american-cancer-society
Edward Sherwood, MD, PhDEdward Sherwood, MD, PhD
Overview: Immunopathogenesis of sepsis, innate immunity Research Interests. We demonstrated that ß2 microglobulin knockout mice that are depleted of natural killer (NK) cells by treatment with anti-asialoGM1 exhibit decreased systemic inflammation, less metabolic acidosis, reduced hypothermia, better hemodynamic function and improved survival compared to control mice following cecal ligation and puncture (CLP). ß2MKO/aAsGM1 mice have multiple immunological defects including an absence of CD8+ T, natural killer (NK) and natural killer T (NKT) cells as well as deficient expression of the class I major histocompatability complex (MHC-I) and CD1 molecules. Our recent ?ndings strongly support the contention that depletion of CD8+ T and NK cells are the primary factors providing protection from CLP-induced injury in ß2MKO/aAsGM1 mice. Most recently, we have focused on the contributions of NK cells to the pathogenesis of septic shock caused by cecal ligation and puncture. Our recent studies ...
https://microbiology.utmb.edu/faculty/edward-sherwood-md-phd
KAKEN - Research Projects | Creation of Transgenic Mice of Dialysis-Related Amyloidosis (KAKENHI-PROJECT-10670990)KAKEN - Research Projects | Creation of Transgenic Mice of Dialysis-Related Amyloidosis (KAKENHI-PROJECT-10670990)
Principal Investigator：MARUYAMA Hiroki, Project Period (FY)：1998 - 2000, Research Category：Grant-in-Aid for Scientific Research (C), Section：一般, Research Field：Kidney internal medicine
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10670990/
15 Common Causes of Amyloidosis15 Common Causes of Amyloidosis
DRA stands for dialysis-related amyloidosis. This form of amyloidosis is prominent in older adults. This is due to the fact that the prominent cause of DRA is dialysis for five years or more. Various studies have shown a direct correlation between long-term dialysis and the development of this type of amyloidosis. In this form of amyloidosis, beta-2 microglobulin deposits start to build up in the blood due to the dialysis.. The buildup happens at a relatively slow pace, but it eventually gets to the point where symptoms will develop. Most doctors believe that the beta-2 microglobulin buildup begins immediately starting from when the dialysis is initiated but remains asymptomatic until the fifth year or beyond.. Some patients have even experienced symptoms of DRA sooner than five years, but it remains the average after analyzing a large number of cases. Patients relying on dialysis should be on the lookout for this form of amyloidosis.. ...
https://simplyhealth.today/15-common-causes-of-amyloidosis/
Humanitarian Device Exemption (HDE)
Approval for the lixelle® ß2-microglobulin apheresis column (also called the beta2-microglobulin apheresis column or ß2m). This device is indicated for the treatment of patients with clinically diagnosed dialysis-related amyloidosis (dra ...
https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfHDE/hde.cfm?id=375574
Correlation of Beta-2 Microglobulin with serum creatinine and creatinine clearance in patients with different levels of renal...Correlation of Beta-2 Microglobulin with serum creatinine and creatinine clearance in patients with different levels of renal...
Correlation of Beta-2 Microglobulin with serum creatinine and creatinine clearance in patients with different levels of renal function
http://gjms.com.pk/ojs2x/index.php/gjms/article/view/462/332
Other - Australian Amyloidosis NetworkOther - Australian Amyloidosis Network
This can lead to beta2 -microglobulin amyloidosis mainly affecting the joints causing osteoarticular destruction but also muscle, tendon, ligament and sometimes gastrointestinal tract ...
https://amyloidosis.net.au/health-professionals/amyloidosis-types/other/
Human Gene HLA-A (uc011gqw.2) Description and Page IndexHuman Gene HLA-A (uc011gqw.2) Description and Page Index
RefSeq Summary (NM_002116): HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq, Jul 2008 ...
http://rohsdb.cmb.usc.edu/GBshape/cgi-bin/hgGene?hgg_gene=uc011gqw.2&hgg_prot=B0UXQ1&hgg_chrom=chr6_mann_hap4&hgg_start=1202631&hgg_end=1205459&hgg_type=knownGene&db=hg19&hgsid=1289098_rEYyzmWZ9Xw4hhMOGbGzlYRwArae
Human Gene HLA-A (uc011gqy.2) Description and Page IndexHuman Gene HLA-A (uc011gqy.2) Description and Page Index
RefSeq Summary (NM_002116): HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq, Jul 2008 ...
http://rohsdb.cmb.usc.edu/GBshape/cgi-bin/hgGene?hgg_gene=uc011gqy.2&hgg_prot=E9PNV0&hgg_chrom=chr6_mann_hap4&hgg_start=1203428&hgg_end=1205948&hgg_type=knownGene&db=hg19&hgsid=1289098_rEYyzmWZ9Xw4hhMOGbGzlYRwArae
DSpace at EWHA: A prospective, open-label, multicenter, observational study to evaluate the efficacy and safety of bortezomib...DSpace at EWHA: A prospective, open-label, multicenter, observational study to evaluate the efficacy and safety of bortezomib...
Bortezomib-melphalan-prednisone (VMP) showed superior efficacy versus MP as first-line treatment for transplantation-ineligible multiple myeloma (MM). This study investigated the efficacy of VMP for Korean patients with MM. Overall, 177 MM patients received 9 cycles of VMP in this prospective, multicenter, observational study. The primary endpoint was 2-year progression-free survival (PFS). Thirty-nine (22%) patients were aged >= 75 years and 83 (47.4%) patients had International Staging System stage III. A median of 5 cycles were delivered. Overall response rate (ORR) was 72.9%, and complete response (CR) rate was 20.3%. With a median follow-up of 11.9 months, median PFS was 17 months. The 2-year PFS and overall survival (OS) rates were 29.2% and 80.0%, respectively. Median OS was not reached. PFS was significantly different depending on performance status (Eastern Cooperative Oncology Group < 2 vs. >= 2; p = 0.0002), beta(2)-microglobulin level (< 5.5 vs. = 5.5 mg/L; p = 0.0481), and ...
http://dspace.ewha.ac.kr/handle/2015.oak/235536
OpenAIRE - Publication: Measurement of urinary beta co...OpenAIRE - Publication: Measurement of urinary beta co...
Measurement of urinary beta core fragment of human chorionic gonadotrophin in women with vulvovaginal malignancy and its prognostic significance
https://www.openaire.eu/search/publication?articleId=core_ac_uk__::195454c3eb3934dabe42616f41033130
Small Round Blue Pill With M On One Side And H25 The Other - Topics - MedsChatSmall Round Blue Pill With M On One Side And H25 The Other - Topics - MedsChat
Small Round Blue Pill With M On One Side And H25 The Other - Topics (Showing results 1 - 6 of 6)... round blue pill with m on one side and 15 other: Small blue round pill. M on one side,H25 on the other. Can you identify for me please? ## The tablet... h25 on one side m the other very small round blue pill: I wondered
https://www.medschat.com/topics/small-round-blue-pill-with-m-on-one-side-and-h25-the-other/
Structure Cluster - 1I1F: Crystal structure of human class i mhc (hla-a2.1) complexed with beta 2-microglobulin and...Structure Cluster - 1I1F: Crystal structure of human class i mhc (hla-a2.1) complexed with beta 2-microglobulin and...
1I1F: The structural basis for the increased immunogenicity of two HIV-reverse transcriptase peptide variant/class I major histocompatibility complexes.
http://www.rcsb.org/pdb/explore/structureCluster.do?structureId=1I1F
alpha1-Microglobulin, a new low molecular weight plasma proteinalpha1-Microglobulin, a new low molecular weight plasma protein
A new low molecular weight protein was purified from the urine of uraemic patients. The protein was found to be glycoprotein with a molecular weight of 31 500, determined by SDS-polyacrylamide gel electrophoresis, and a carbohydrate content of 19%. It was electrophoretically heterogenous and migrate …
https://pubmed.ncbi.nlm.nih.gov/1000859/
Commercial Construction » Precast Concrete Construction
In the mid-nineties, I was heading a civil design department for a large EPC contractor in South East Asia. We had received an order to build a paper plant.. The primary building in a paper plant is the paper machine building. A typical paper machine building is about 300 m long. The building typically has two floors, one at ground level, and one at about 7.5 m level. The paper machine is installed on a foundation that is not connected to the building. The machine is accessible from the machine hall at 7.50 m level. This building houses other complex and heavy machinery and has very stringent requirements with respect to quality, structural design and stability. The roof is high up and some of the sections of this building are subject to temperatures between 50 to 60 0 C. A large overhead crane straddles the upstairs machine hall. The differential settlement in the paper machine foundation has to be less than one mm and overall settlement at any point less than 1.25 mm. This building, with all ...
https://nalinkube.info/archives/16
Beta-2-microglobulin, Random Urine With Creatinine - Quest Diagnostics Nichols Institute of ValenciaBeta-2-microglobulin, Random Urine With Creatinine - Quest Diagnostics Nichols Institute of Valencia
The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed ...
http://www.specialtylabs.com/tests/details.asp?id=38994
Beta-2 Microglobulin - Sekisui DiagnosticsBeta-2 Microglobulin - Sekisui Diagnostics
Sekisui Diagnostics has a broad product portfolio to meet your diagnostics needs. Systems, reagents, tests, enzymes and specialty biochemicals. Quality products for laboratory and research environments.
https://www.sekisuidiagnostics.com/products-all/beta-2-microglobulin/
KAKEN - Researchers | MIZUNO Yuho (50200019)KAKEN - Researchers | MIZUNO Yuho (50200019)
Affiliation：Fujita Health Univ.,Sch.of Medicine,Assistant,医学部,助手, Research Field：Digestive surgery, Keywords：Lymphokine activated killer,Beta 2 microgobulin,Cancer metastasis,Interleukin-2,beta_2 microglobulin,胸管リンパ球,高速度ビデオ,組織適合抗原,養子免疫療法,Major histocompatibility complex, # of Research Projects：2, # of Research Products：0
https://nrid.nii.ac.jp/nrid/1000050200019/
Chemistry - eINFOChemistry - eINFO
A select number of offers are issued in December and are based on a combination of Grade 11 and Grade 12 results. To be eligible for an early offer you must have 1.0 final Grade 12 result at the 4U or 4M-level, and five Grade 11 U or M-level credits. Averages are in the high 80s or 90s. The first major round of admission offers to Ontario applicants is in February. Admission averages are calculated using a minimum 3.0 first-semester Grade 12 4U or 4M finals, with registration in 3.0 additional 4U or 4M credits, including prerequisites. If you are in a non-semester school, we will use 6.0 mid-term grades at the Grade 12 4U or 4M level, including prerequisites. The final round of admission offers happens in May. If you do not receive an offer in February, or if you are still in studies and received an alternate program offer, we will automatically reassess you for eligibility for your preferred program in May. We will continue to make offers based on final grades, as well as summer school grades ...
http://electronicinfo.ca/programs/72
Proc 97597Proc 97597
Billing E&M level with mod 25 and procedure 97597; no wound closure, just a dressing application. Medicare is paying the E&M but not processin
https://www.aapc.com/memberarea/forums/58627-proc-97597-a.html
Stomach. (a) The expression of PPARα, β, and γ mRNA | Open-iStomach. (a) The expression of PPARα, β, and γ mRNA | Open-i
Stomach. (a) The expression of PPARα, β, and γ mRNA is shown across the fetal age range. Log plot of mean ± SEM Ct is normalized to β-2-microglobulin (B2M
https://openi.nlm.nih.gov/detailedresult.php?img=PMC2913814_PPAR2010-690907.005&req=4
Cleaner protein protects against atherosclerosis - Interventional...Cleaner protein protects against atherosclerosis - Interventional...
We have an innate mechanism that ensures that our blood vessels do not become blocked. The protein A1M, alpha-1-microglobulin, is naturally present in the body and prevents oxidation of blood fats-a major cause of atherosclerosis. The discovery is the work of a research group led by Bo Åkerström of Lund University, Sweden.. ...
https://interventionalnews.com/cleaner-protein-protects-against-atherosclerosis/
AQMS: New certification for the Continuous Suspended Particulate Beta Attenuation Analyzer MP101M on Environmental XPRTAQMS: New certification for the Continuous Suspended Particulate Beta Attenuation Analyzer MP101M on Environmental XPRT
We are pleased to announce that effective July 8, 2011, the Continuous Suspended Particulate Beta Attenuation Analyzer MP101M with associated module CPM has ...
https://www.environmental-expert.com/news/aqms-new-certification-for-the-continuous-suspended-particulate-beta-attenuation-analyzer-mp101m-254482
Salesforce APAC CMO: we spent $3m on gender pay parity last year | The DrumSalesforce APAC CMO: we spent $3m on gender pay parity last year | The Drum
Salesforce has undertaken a significant commitment to equality, according to APAC CMO Wendy Johnstone, putting its money where its mouth is on the gender wage gap.
https://www.thedrum.com/news/2016/12/05/salesforce-apac-cmo-we-spent-3m-gender-pay-parity-last-year
Tough Decision Looms for Texas A&M on Whether to Play or Sit Johnny Manziel | Bleacher ReportTough Decision Looms for Texas A&M on Whether to Play or Sit Johnny Manziel | Bleacher Report
Another day, another new chapter added to the ongoing Johnny Manziel saga. ESPN reported on Tuesday that an autograph broker paid the Texas A&M quarterback $7,500 for 300 ...
http://bleacherreport.com/articles/1730032-tough-decision-looms-for-texas-am-on-whether-to-play-or-sit-johnny-manziel
Infection Biology - Virology lab by Emil Lindström on PreziInfection Biology - Virology lab by Emil Lindström on Prezi
Do you really want to delete this prezi? Neither you, nor the coeditors you shared it with will be able to recover it again. DeleteCancel ...
https://prezi.com/wprgnklnrd7x/infection-biology-virology-lab/
The Data Day, A few days: January 6-10 2014 - Too much information
Tibco reported Q4 net inc of $44.5m on revenue up 6.4% to $315.5m, FY net inc of $84m on revenue up 4.4% to $1.07bn. http://t.co/i2WSL95jfk. - Matt Aslett (@maslett) January 6, 2014 ...
https://blogs.451research.com/information_management/2014/01/10/the-data-day-a-few-days-january-6-10-2014/
Ex-manager defends Arsene Wengers decision to spend £52m on new Arsenal signingEx-manager defends Arsene Wengers decision to spend £52m on new Arsenal signing
Gerard Houllier has defended Arsenal manager Arsene Wengers decision to spend a club-record fee on signing Alexandre Lacazette this summer. The France
https://www.thesportreview.com/2017/07/arsenal-transfer-news-latest-alexandre-lacazette-fee-gerard-houllier/
Square Mile Lends $161M on Rockwood, Midtown Equities One Broadway [UPDATED] - Commercial ObserverSquare Mile Lends $161M on Rockwood, Midtown Equities One Broadway [UPDATED] - Commercial Observer
Square Mile Capital Management lent $161 million to Midtown Equities and Rockwood Capital for its $140 million purchase of One Broadway.
https://commercialobserver.com/2018/12/square-mile-capital-management-124m-rockwood-capital-midtown-equities-one-broadway/
VIDEOGAME ADDICTION by Vika M on PreziVIDEOGAME ADDICTION by Vika M on Prezi
Retrieved from http://www.telegraph.co.uk/news/worldnews/asia/southkorea/7376178/Korean-couple-let-baby-starve-to-death-while-caring-for-virtual-child. ...
https://prezi.com/cqdeyys80pbg/videogame-addiction/
Re^4: Dynamic scoping of capture variables ($1, $2, etc.)
Thanks for your explanation Moritz. I meant $1 value got changed similar to $_ value for better understanding. I know that $_ value getting changed due to substitute operator replaces matched digits to null string. I have a doubt in your example, how $1 value getting changed every recursive call. As per your code, your m// expression will match first digits ( 55 ) at all time as per my understanding. Of course, when I checked the code, it gives $1 value as 55, 666, 7777 and 1 respectively. Kindly give me some detail about it ...
http://www.perlmonks.org/index.pl?node_id=1009495
The Data Day: February 9, 2018 - Too much information
Teradata reported a net loss of $67m in FY17 down 4% at $2.16bn, as well as a net loss of $74m on Q4 revenue flat at $626m, sets FY18 revenue guidance at $2.15bn-$2.2bn https://t.co/q9eNoRBcaS. - Matt Asletts The Data Day (@thedataday) February 8, 2018 ...
https://blogs.451research.com/information_management/2018/02/09/the-data-day-february-9-2018/
beta ureidopropionase Lysates: Novus Biologicalsbeta ureidopropionase Lysates: Novus Biologicals
beta ureidopropionase Lysates available through Novus Biologicals. Browse our beta ureidopropionase Lysates all backed by our Guarantee+.
https://www.novusbio.com/lysates/beta-ureidopropionase
Evernote for Windows 6.8 Beta 5 Released - Evernote for Windows Requests (Versions 6.25.1 and under) - Evernote User ForumEvernote for Windows 6.8 Beta 5 Released - Evernote for Windows Requests (Versions 6.25.1 and under) - Evernote User Forum
Hi folks - Were excited to announce Windows 6.8 Beta 5. You can install it here or by checking for updates. Fixes in this beta include: A fix for an issue where the old name of an attachment re-appears after switching notes A fix for an issue where the Google sign in page doesnt appear when con...
https://discussion.evernote.com/forums/topic/110452-evernote-for-windows-68-beta-5-released/
Beta-2 microglobulinBeta-2 microglobulin
Low levels of β2 microglobulin can indicate non-progression of HIV. Levels of β2 microglobulin can be elevated in multiple ... Mice models deficient for the β2 microglobulin gene have been engineered. These mice demonstrate that β2 microglobulin is ... the β2 microglobulin protein is encoded by the B2M gene. β2 microglobulin lies beside the α3 chain on the cell surface. Unlike ... β2 microglobulin (B2M) is a component of MHC class I molecules. MHC class I molecules have α1, α2, and α3 proteins which are ...
https://en.wikipedia.org/wiki/Beta-2_microglobulin
B2MRB2MR
Beta-2-microglobulin regulator is a protein in humans that is encoded by the B2MR gene. "Entrez Gene: Beta-2-microglobulin ...
https://en.wikipedia.org/wiki/B2MR
HLA-AHLA-A
The α chain is encoded by a variant HLA-A gene, and the β chain (β2-microglobulin) is an invariant β2 microglobulin molecule. ... "OMIM Entry - * 109700 - BETA-2-MICROGLOBULIN;B2M". Online Mendelian Inheritance in Man. Johns Hopkins University. 5 Aug 2016. ... The β2 microglobulin protein is encoded by the B2M gene, which is located at chromosome 15q21.1 in humans. MHC Class I ... At this point the class I complex consists of an HLA-A protein bonded to a β2-microglobulin and a short peptide. It is still ...
https://en.wikipedia.org/wiki/HLA-A
CD4CD4
MHC class I contains Beta-2 microglobulin. The short cytoplasmic/intracellular tail (C) of CD4 contains a special sequence of ... For the first 2 years of HIV therapy, CD4 counts may be done every 3-6 months. If a patient's viral load becomes undetectable ... 2 (7): 580-5. doi:10.1093/embo-reports/kve141. PMC 1083955. PMID 11463741. Greenway AL, Holloway G, McPhee DA, Ellis P, Cornall ... 2 (2): 141-51. doi:10.2174/1570162043484924. PMID 15078178. Hout DR, Mulcahy ER, Pacyniak E, Gomez LM, Gomez ML, Stephens EB ( ...
https://en.wikipedia.org/wiki/CD4
Peyers patchPeyer's patch
Zijlstra M, Auchincloss H, Loring JM, Chase CM, Russell PS, Jaenisch R (April 1992). "Skin graft rejection by beta 2- ... microglobulin-deficient mice". The Journal of Experimental Medicine. 175 (4): 885-93. doi:10.1136/gut.6.3.225. PMC 1552287. ... 66 (2): 189-203. doi:10.1016/s0016-5085(74)80102-2. PMID 4810912. Onori P, Franchitto A, Sferra R, Vetuschi A, Gaudio E (May ...
https://en.wikipedia.org/wiki/Peyer's_patch
MicroglobulinMicroglobulin
It can be contrasted to macroglobulin., Examples include: Beta-2 microglobulin Alpha-1-microglobulin "Definition: microglobulin ... Microglobulin is a globulin of relatively small molecular weight. ...
https://en.wikipedia.org/wiki/Microglobulin
Waldenström macroglobulinemiaWaldenström macroglobulinemia
Beta-2 microglobulin is elevated in proportion to tumor mass. Coagulation abnormalities may be present. Prothrombin time, ... 109/L B2-microglobulin > 3 mg/L Serum monoclonal protein concentration > 70 g/L The risk categories are: Low: ≤ 1 adverse ... Beta-2 microglobulin and C-reactive protein test results are not specific for Waldenström macroglobulinemia. ... An M component with beta-to-gamma mobility is highly suggestive of Waldenström macroglobulinemia. Immunoelectrophoresis and ...
https://en.wikipedia.org/wiki/Waldenström_macroglobulinemia
Follicular lymphomaFollicular lymphoma
... the gene for beta-2 microglobulin), and SGK1. Except for the t(14:18)(q32:q21.3) translocation and EZH2 mutations which lead to ... encoding the Ig-beta protein component of the B-cell receptor); 4) gene-inactivating mutations in TNFAIP3, CD58 (encoding the ... high levels of Beta-2 macroglobulin or bone marrow involvement). The combination of lenalidomide with rituximab has shown good ... elevated levels of serum lactose dehydrogenase or beta-2 microglobulin; presence of localized bone lesions; kidney involvement ...
https://en.wikipedia.org/wiki/Follicular_lymphoma
Plasma cell leukemiaPlasma cell leukemia
... higher levels of serum lactate dehydrogenase and Beta-2 microglobulin; and c) lower rates of bone but higher rates of soft ... It is the terminal stage and most aggressive form of these dyscrasias, constituting 2% to 4% of all cases of plasma cell ... median survival rates from the time of diagnosis for pPCL and sPCL were 8-11 months and 2-8 months, respectively, even when ...
https://en.wikipedia.org/wiki/Plasma_cell_leukemia
Cystatin CCystatin C
... each half is made up of the long alpha helix and one beta strand of one partner, and four beta strands of the other partner. ... "Effect of corticosteroid therapy on serum cystatin C and beta2-microglobulin concentrations". Clinical Chemistry. 48 (7): 1123- ... Cystatin C was first described as 'gamma-trace' in 1961 as a trace protein together with other ones (such as beta-trace) in the ... Akbari A, Lepage N, Keely E, Clark HD, Jaffey J, MacKinnon M, Filler G (May 2005). "Cystatin-C and beta trace protein as ...
https://en.wikipedia.org/wiki/Cystatin_C
Neonatal Fc receptorNeonatal Fc receptor
Ghetie V, Hubbard JG, Kim JK, Tsen MF, Lee Y, Ward ES (March 1996). "Abnormally short serum half-lives of IgG in beta 2- ... Microglobulin is important for cell surface expression and pH-dependent IgG binding of human FcRn". Journal of Cell Science. ... It is an IgG Fc receptor which is similar in structure to the MHC class I molecule and also associates with beta-2- ... microglobulin. In rodents, FcRn was originally identified as the receptor that transports maternal immunoglobulin G (IgG) from ...
https://en.wikipedia.org/wiki/Neonatal_Fc_receptor
Richters transformationRichter's transformation
... beta-2 microglobulin genes; translocations of the BCL6 and BCL2 genes; and losses of PRDM1 and TNFAIP3 genes. There is an ... low blood platelet counts and/or elevated serum beta-2-microglobulin levels; 4) CLl/SLL cells which develop deletions in the ... Finally, a study of 51 type 2 HL-RT cases showed that the RS cells expressed PAX5 in 100%, CD30 in 100%, CD15 in 92%, CD20 in ... One study found that 53% of 14 type 2 HL-RT cases had, and 47% did not have, antibody-producing gene changes in their RS cells ...
https://en.wikipedia.org/wiki/Richter's_transformation
EMID2EMID2
A collagen-binding, I domain-containing, beta(1)-associated integrin alpha-chain present in muscle tissues". J. Biol. Chem. 274 ... Homma N, Gejyo F, Isemura M, Arakawa M (1989). "Collagen-binding affinity of beta-2-microglobulin, a preprotein of hemodialysis ... 249 (2): 204-18. doi:10.1006/dbio.2002.0764. PMID 12221002. "Entrez Gene: EMID2 EMI domain containing 2". Lim J, Hao T, Shaw C ...
https://en.wikipedia.org/wiki/EMID2
Cadmium poisoningCadmium poisoning
The urinary beta-2 microglobulin test is an indirect method of measuring cadmium exposure. Under some circumstances, the ... Increased concentrations of urinary beta-2 microglobulin can be an early indicator of kidney dysfunction in persons chronically ... 2 (3): 215-229. doi:10.1007/BF03353912. hdl:2115/53361. ISSN 1867-383X. S2CID 1902243. (IARC)International Agency for Research ... 208 (1-2): 123-6. Bibcode:1997ScTEn.208..123T. doi:10.1016/S0048-9697(97)00273-8. PMID 9496656. Boparei. (2010). Kinetics and ...
https://en.wikipedia.org/wiki/Cadmium_poisoning
Mucosal associated invariant T cellMucosal associated invariant T cell
... alpha/beta T cells demonstrates preferential use of several V beta genes and an invariant TCR alpha chain". Journal of ... Like MHC class I, MR1 is found in all a large variety of cells and associates with β2-microglobulin. However, it remains to be ... with beta(2)-microglobulin". Biochemical and Biophysical Research Communications. 290 (2): 722-729. doi:10.1006/bbrc.2001.6277 ... The TCRα originates from the rearrangement of TCRα variable (V) and joining (J) gene segments TRAV1-2/TRAJ12/20/33 during VDJ ...
https://en.wikipedia.org/wiki/Mucosal_associated_invariant_T_cell
CD1DCD1D
1994). "Beta 2-microglobulin-independent MHC class Ib molecule expressed by human intestinal epithelium". Science. 265 (5169): ... 1999). "Immunolocalization of CD1d in human intestinal epithelial cells and identification of a beta2-microglobulin-associated ... 200 (1-2): 149-156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. Kawano T, Cui J, Koezuka Y, et al. (1997). "CD1d- ... 54 (2): 122-127. doi:10.1034/j.1399-0039.1999.540202.x. PMID 10488738. CD1d+antigen at the US National Library of Medicine ...
https://en.wikipedia.org/wiki/CD1D
Ovarian cancerOvarian cancer
Estrogen receptor beta gene (ESR2) seems to be a key to pathogenesis and response to therapy. Other genes that have been ... In addition, the cancer markers used vary with tumor type: choriocarcinomas are monitored with beta-HCG and endodermal sinus ... The OVA1 panel includes CA-125, beta-2 microglobulin, transferrin, apolipoprotein A1, and transthyretin. OVA1 above 5.0 in ... Patients who have spread of the disease to other parts of the body tend to die 2 years after the diagnosis. Extra-ovarian ...
https://en.wikipedia.org/wiki/Ovarian_cancer
Peptide loading complexPeptide loading complex
Together with β2-microglobulin (β2m), MHC-I heavy chains form assemblies of heterodimers that act as receptors for antigenic ... Ortmann B, Androlewicz MJ, Cresswell P (April 1994). "MHC class I/beta 2-microglobulin complexes associate with TAP ... In addition to this, β2-microglobulin (β2m) is attached to the heavy chains of the heterodimers and as a whole they act as ... heavy chain and β2 microglobulin). The use of a photo-cleavable high-affinity peptide allowed researchers to form a stable ( ...
https://en.wikipedia.org/wiki/Peptide_loading_complex
AmyloidosisAmyloidosis
Amyloid-forming proteins aggregate into distinctive fibrillar forms with a beta-sheet structure. The beta-sheet form of amyloid ... In beta 2-microglobulin amyloidosis, males have high risk of getting carpal tunnel syndrome. Aβ2MG amyloidosis (Hemodialysis ... beta] cells and is co secreted with insulin." (Rang and Dale's Pharmacology, 2015.)[citation needed] Amyloid proteins deposit ... AL amyloidosis occurs in about 3-13 per million people per year and AA amyloidosis in about 2 per million people per year. The ...
https://en.wikipedia.org/wiki/Amyloidosis
Thymidine kinase in clinical chemistryThymidine kinase in clinical chemistry
Hallek M, Wanders L, Ostwald M, Busch R, Senekowitsch R, Stern S, Schick HD, Kuhn-Hallek I, Emmerich B (1996). "Serum beta(2)- ... microglobulin and serum thymidine kinase are independent predictors of progression-free survival in chronic lymphocytic ... beta-2 microglobulin, and thymidine kinase". Leukemia & Lymphoma. 18 (1-2): 87-92. doi:10.3109/10428199509064927. PMID 8580834 ... 3.0.co;2-j. PMID 2167141. Korkmaz T, Seber S, Okutur K, Basaran G, Yumuk F, Dane F, Ones T, Polat O, Madenci OC, Demir G, ...
https://en.wikipedia.org/wiki/Thymidine_kinase_in_clinical_chemistry
Melanoma inhibitory activityMelanoma inhibitory activity
2007). "Melanoma inhibiting activity protein (MIA), beta-2 microglobulin and lactate dehydrogenase (LDH) in metastatic melanoma ... 18 (2): 92-101. doi:10.1111/j.1600-0749.2005.00212.x. PMID 15760338. Aung PP, Oue N, Mitani Y, et al. (2006). "Systematic ... 14 (2): 91-5. doi:10.1097/00008390-200404000-00003. PMID 15057037. S2CID 1429873. Marr DG, Poser I, Shellman YG, et al. (2005 ...
https://en.wikipedia.org/wiki/Melanoma_inhibitory_activity
Haemodialysis-associated amyloidosisHaemodialysis-associated amyloidosis
September 1993). "beta 2-Microglobulin modified with advanced glycation end products is a major component of hemodialysis- ... Long-term haemodialysis results in a gradual accumulation of β2 microglobulin, a serum protein, in the blood. It accumulates ... Use of high flux dialyzers Use of Beta 2 globulin absorber Preserve the residual kidney functions Early kidney transplant In ... Destructive spondylarthropathy with b2-microglobulin deposits in a uremic patient before chronic hemodialysis. Nephron 1991; 59 ...
https://en.wikipedia.org/wiki/Haemodialysis-associated_amyloidosis
HemodialysisHemodialysis
Because beta-2-microglobulin is a large molecule, with a molecular weight of about 11,600 daltons, it does not pass at all ... Beta-2-M is removed with high-flux dialysis, but is removed even more efficiently with IHDF. After several years (usually at ... The goal of high-flux membranes is to pass relatively large molecules such as beta-2-microglobulin (MW 11,600 daltons), but not ... Beta-2-M amyloidosis can cause very serious complications, including spondyloarthropathy, and often is associated with shoulder ...
https://en.wikipedia.org/wiki/Hemodialysis
Diffuse large B-cell lymphomaDiffuse large B-cell lymphoma
... unexplained elevations in their blood levels of lactic acid dehydrogenase and beta-2 microglobulin in many cases; malignant ... 30 (1-2): 131-138. doi:10.1016/j.beha.2016.08.029. PMID 28288708. Abuelgasim KA, Rehan H, Alsubaie M, Al Atwi N, Al Balwi M, ... 2 years but also lethal cytokine release syndrome and neurotoxicity responses to this therapy. As a consequence of these ... 30 (1-2): 50-55. doi:10.1016/j.beha.2016.11.001. PMID 28288717. Abramson JS (September 2019). "Hitting back at lymphoma: How do ...
https://en.wikipedia.org/wiki/Diffuse_large_B-cell_lymphoma
Anders GrubbAnders Grubb
... factor D and beta 2-microglobulin as a measure of glomerular filtration rate". Acta Medica Scandinavica. 218 (5): 499-503. doi: ... 268 (2): 287-294. doi:10.1042/bj2680287 - via Silverchair. Barrett, A. J.; Davies, M. E.; Grubb, A. (1984). "The place of human ... 120 (2): 631-636. doi:10.1016/0006-291x(84)91302-0. PMID 6203523. Björck, Lars; Åkesson, Per; Bohus, Martin; Trojnar, Jerzy; ... 170 (2): 370-374. doi:10.1016/0014-5793(84)81346-0 - via ScienceDirect. Janowski, R.; Kozak, M.; Jankowska, E.; Grzonka, Z.; ...
https://en.wikipedia.org/wiki/Anders_Grubb
Beta globulinBeta globulin
Examples of beta globulins include: beta-2 microglobulin plasminogen angiostatins properdin sex hormone-binding globulin ... Beta globulins are a group of globular proteins in plasma that are more mobile in alkaline or electrically charged solutions ... "Examples of Protein Electrophoretograms" at ufl.edu Beta-globulins at the US National Library of Medicine Medical Subject ...
https://en.wikipedia.org/wiki/Beta_globulin
Brian DurieBrian Durie
Furthermore, Durie showed it was possible to stratify myeloma patients based on combinations of serum beta 2 microglobulin with ... His research concluded that serum beta 2 microglobulin is the most powerful prognostic factor currently available for multiple ... 3.0.co;2-u. ISSN 0008-543X. PMID 1182674. Durie, B.; Salmon, S. (1975-12-12). "High speed scintillation autoradiography". ...
https://en.wikipedia.org/wiki/Brian_Durie
ESAT-6ESAT-6
"The ESAT-6 Protein of Mycobacterium tuberculosis Interacts with Beta-2-Microglobulin (β2M) Affecting Antigen Presentation ...
https://en.wikipedia.org/wiki/ESAT-6
HLA-GHLA-G
This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is ... 52 (2): 97-103. doi:10.1016/j.patbio.2003.04.006. PMID 15001239. Tolstrup M, Ostergaard L, Laursen AL, Pedersen SF, Duch M ( ... 2 (7): 580-585. doi:10.1093/embo-reports/kve141. PMC 1083955. PMID 11463741. Langat DK, Hunt JS (November 2002). "Do nonhuman ... Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 ...
https://en.wikipedia.org/wiki/HLA-G
Antigen-presenting cellAntigen-presenting cell
They use an MHC class I molecule coupled to beta-2 microglobulin to display endogenous peptides on the cell membrane. These ... 162 (2 Pt B): 103-12. doi:10.1016/j.imlet.2014.10.011. PMID 25455596. Hivroz C, Chemin K, Tourret M, Bohineust A (2012). " ... 32 (2): 139-55. doi:10.1615/critrevimmunol.v32.i2.30. PMID 23216612. Barral DC, Brenner MB (December 2007). "CD1 antigen ...
https://en.wikipedia.org/wiki/Antigen-presenting_cell
Index of biochemistry articlesIndex of biochemistry articles
... beta adrenergic receptor - beta sheet - beta-1 adrenergic receptor - beta-2 adrenergic receptor - beta-thromboglobulin - ... transforming growth factor beta - transforming growth factor beta receptor - transient receptor potential - translation ( ... alpha-beta T-cell antigen receptor - alpha-fetoprotein - alpha-globulin - alpha-macroglobulin - alpha-MSH - Ames test - amide ... interferon-beta - interleukin receptor - interleukin-1 receptor - interleukin-2 receptor - interleukin-3 - interleukin-3 ...
https://en.wikipedia.org/wiki/Index_of_biochemistry_articles
Chromosome 6Chromosome 6
The human leukocyte antigen lies on chromosome 6, with the exception of the gene for β2-microglobulin (which is located on ... beta polypeptide (maple syrup urine disease) (6q14.1) BMIQ3: body mass index QTL 3 TMEM242 encoding transmembrane protein ... N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase (6p24.3) GMDS: GDP-mannose 4,6-dehydratase (6p25.3) HCG4P11: ... cAMP-dependent protein kinase inhibitor beta (6p22.31) PLAGL1: (6q24.2) RCD1: retinal cone dystrophy 1 RFPL4B: Ret finger ...
https://en.wikipedia.org/wiki/Chromosome_6
Maria de SousaMaria de Sousa
Santos, M., Schilham, MW, Rademakers, LHPM, Marx, JJM, de Sousa, M. and Clevers, H. "Defective iron homeostasis in beta 2- ... S. "Iron overload in ß2 microglobulin deficient mice". Immunol. Lett. 39: 105-111. 1994. ... microglobulin knockout mice recapitulates Hereditary Hemochromatosis in man". J.Exp.Med, 184: 1975-1985. 1996. De Almeida SF, ... Minder, Raphael (2 July 2020). "Maria de Sousa, Leading Portuguese Scientist, Dies at 80". The New York Times. Retrieved 5 ...
https://en.wikipedia.org/wiki/Maria_de_Sousa
List of MeSH codes (D12.776)List of MeSH codes (D12.776)
... beta-crystallin a chain MeSH D12.776.306.366.300.200 - beta-crystallin b chain MeSH D12.776.331.199.750.500 - succinate ... thyroid hormone receptors beta MeSH D12.776.624.664.700.915 - RNA-binding protein FUS MeSH D12.776.624.664.700.957 - stathmin ... Retinoid X receptor beta MeSH D12.776.826.701.500.750 - Retinoid X receptor gamma MeSH D12.776.826.750.074.249 - coup ... transforming growth factor beta MeSH D12.776.467.374.440.890 - interferon type i MeSH D12.776.467.374.440.890.125 - interferon ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776)
Urine test stripUrine test strip
The proportions are 78% beta-hydroxybutyric acid, 20% acetoacetic acid and 2% acetone. The test used in the urine test strips ... Other proteins include small amounts of serum and tubular microglobulins. Uromodulin produced by the renal tubular epithelial ... acetoacetic acid and beta-hydroxybutyric acid. Elevated concentrations of ketones are not generally found in urine, as all ... Water The test does not measure beta-hydroxybutyric acid and it is only weakly sensitive to acetone when glycine is added to ...
https://en.wikipedia.org/wiki/Urine_test_strip
Cerebrospinal fluidCerebrospinal fluid
If a leak is identified, a beta-2 transferrin test of the leaking fluid, when positive, is highly specific and sensitive for ... Choroid plexuses also secrete growth factors, iodine, vitamins B1, B12, C, folate, beta-2 microglobulin, arginine vasopressin ... Infants have a CSF volume of 4 mL/kg, children have a CSF volume of 3 mL/kg, and adults have a CSF volume of 1.5-2 mL/kg. A ... 83 (2): S86-90. doi:10.1016/j.diff.2011.10.007. PMID 22101065. Venturi S, Venturi M (2014). "Iodine, PUFAs and Iodolipids in ...
https://en.wikipedia.org/wiki/Cerebrospinal_fluid
List of MeSH codes (D12.776.124)List of MeSH codes (D12.776.124)
... beta-thromboglobulin MeSH D12.776.124.790.223.200 - complement factor h MeSH D12.776.124.790.223.338 - hemopexin MeSH D12.776. ... pregnancy-associated alpha 2-macroglobulins The list continues at List of MeSH codes (D12.776.157). (Wikipedia articles in need ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776.124)
Tetramer assayTetramer assay
Class I MHC molecules are made up of a polymorphic heavy α-chain associated with an invariant light chain beta-2 microglobulin ...
https://en.wikipedia.org/wiki/Tetramer_assay
Primary mediastinal (thymic) large B cell lymphomaPrimary mediastinal (thymic) large B cell lymphoma
Increased LDH is seen in approximately 75%,: 370 but unlike other large cell lymphomas, no increase in beta-2 microglobulin is ... 2 (4th ed.). International Agency for Research on Cancer. ISBN 9789283224310. Jaffe, ES; Harris NL; Vardiman JW; Campo E; Arber ... 7 (2): 125-33. PMID 19367254. Dabrowska-Iwanicka A, Walewski JA (2014). "Primary mediastinal large B-cell lymphoma". Curr ... 8 (2): 173-86. doi:10.1586/17474086.2015.994604. hdl:11573/780924. PMID 25537750. S2CID 23040185. Sweetenham, J. Lymphomas ( ...
https://en.wikipedia.org/wiki/Primary_mediastinal_(thymic)_large_B_cell_lymphoma
Cross-presentationCross-presentation
... peptides are loaded onto MHC class I molecules with the help of the peptide loading complex and chaperone proteins such as beta ... 1 (2): 126-34. doi:10.1038/35100512. PMID 11905820. S2CID 5666741. Rock, KL (1996). "A new foreign policy: MHC class I ... Bevan, MJ (1976). "Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not ... 1 (2): 126-134. doi:10.1038/35100512. ISSN 1474-1741. PMID 11905820. S2CID 5666741. Guermonprez, P; Saveanu, L; Kleijmeer, M; ...
https://en.wikipedia.org/wiki/Cross-presentation
Clark L. AndersonClark L. Anderson
Beta 2-microglobulin-, CD8+ T-cell-deficient mice survive inoculation with high doses of vaccinia virus and exhibit altered IgG ... beta2-Microglobulin dependence of the lupus-like autoimmune syndrome of MRL-lpr mice. J. Immunol. 156: 4932-4939. Junghans, R. ... Requirement for a b2-microglobulin-associated Fc receptor for acquisition of maternal IgG by fetal and neonatal mice. J. ... The protection receptor for IgG catabolism is the b2- microglobulin-containing neonatal intestinal transport receptor. Proc. ...
https://en.wikipedia.org/wiki/Clark_L._Anderson
Inclusion bodiesInclusion bodies
Przybycien TM, Dunn JP, Valax P, Georgiou G (January 1994). "Secondary structure characterization of beta-lactamase inclusion ... "Nondenaturing solubilization of beta2 microglobulin from inclusion bodies by L-arginine". Biochem Biophys Res Commun. 328 (1): ... 17 (1-2): 159-169. doi:10.1111/j.1574-6976.1995.tb00198.x. ISSN 0168-6445. PMID 7669342. Jiang, Shann-Tzong; Tzeng, Shinn- ... It is generally assumed that high level expression of non-native protein (higher than 2% of cellular protein) and highly ...
https://en.wikipedia.org/wiki/Inclusion_bodies
IRF2IRF2
... competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other ... 3.0.CO;2-N. PMID 9213219. S2CID 34485265. Masumi A, Wang IM, Lefebvre B, Yang XJ, Nakatani Y, Ozato K (1999). "The Histone ... 3.0.CO;2-L. PMID 11025449. S2CID 22932901. Larrea E, Alberdi A, Castelruiz Y, Boya P, Civeira MP, Prieto J (2001). "Expression ... Interferon regulatory factor 2 is a protein that in humans is encoded by the IRF2 gene. IRF2 encodes interferon regulatory ...
https://en.wikipedia.org/wiki/IRF2
Induced stem cellsInduced stem cells
... for beta-cell maturation) combination (called PNM) can lead to the transformation of some cell types into a beta cell-like ... An RNA interference-based mechanism used a lentiviral vector to express short-hairpin RNAi targeting β2-microglobulin ... Akinci E, Banga A, Tungatt K, Segal J, Eberhard D, Dutton JR, Slack JM (2013). "Reprogramming of various cell types to a beta- ... Overexpression of the three transcription factors, PDX1 (required for pancreatic bud outgrowth and beta-cell maturation), NGN3 ...
https://en.wikipedia.org/wiki/Induced_stem_cells
Sheena RadfordSheena Radford
By studying them, we can discover some of the essential features that enable transmembrane beta-barrel proteins to fold into a ... Sheena's work on dialysis-dependent amyloidosis has shown that protein unfolding of beta-2-microglobulin is a key step in ... These proteins share a similar nanoscale structure, a transmembrane beta-barrel, through which other molecules can pass. ... Archived from the original on 2 May 2014. Anon (2010). "Professor Sheena Radford FRS FMedSci". acmedsci.ac.uk. London: Academy ...
https://en.wikipedia.org/wiki/Sheena_Radford
Beta 2 Microglobulin (B2M) Tumor Marker Test: MedlinePlus Medical TestBeta 2 Microglobulin (B2M) Tumor Marker Test: MedlinePlus Medical Test
A beta-2 microglobulin (B2M) tumor marker test usually measures the amount of B2M in your blood. It can help find out how ... What is a beta-2 microglobulin tumor marker test?. A beta-2 microglobulin tumor marker test measures the amount of a protein ... A beta-2 microglobulin test usually uses a sample of your blood. In certain cases, you may need to provide a 24-hour urine ... A beta-2 microglobulin tumor marker test is most often used if you have been diagnosed with certain cancers of the bone marrow ...
https://medlineplus.gov/lab-tests/beta-2-microglobulin-b2m-tumor-marker-test/
Browsing by Subject beta 2-MicroglobulinBrowsing by Subject "beta 2-Microglobulin"
Normal human serum preparation as a reference for the assay of beta 2 microglobulin  ...
https://extranet.who.int/iris/restricted/browse?authority=beta+2-Microglobulin&type=mesh
Mouse Beta-2-Microglobulin ELISA Kit (ab223590) | AbcamMouse Beta-2-Microglobulin ELISA Kit (ab223590) | Abcam
... for the quantitative measurement of Mouse Beta-2-Microglobulin in Cell culture supernatant, Urine, Serum, Hep Plasma… ... Mouse Beta-2-Microglobulin ELISA Kit is a single-wash 90-min SimpleStep ELISA® ... Beta-2-Microglobulin is the light chain of the class I major histocompatibility complex (MHC); it forms heterodimers with ... Mouse Beta-2-Microglobulin ELISA Kit (ab223590) is a single-wash 90 min sandwich ELISA designed for the quantitative ...
https://www.abcam.com/mouse-beta-2-microglobulin-elisa-kit-ab223590.html?productwalltab=abreviews
beta-2 Microglobulin Antikörper, ELISA Kitsbeta-2 Microglobulin Antikörper, ELISA Kits
Find high quality beta-2 Microglobulin tools for research. Antibodies, ELISA kits, proteins, reagents. Order quickly and easily ... Ausgewählte beta-2 Microglobulin Kategorien. beta-2 Microglobulin Antikörper. High quality antibodies with extensive validation ... beta-2-microglobulin (B2M), beta-2 microglobulin (B2m), beta-2-microglobulin (b2m), beta-2-microglobulin S homeolog (b2m.S), ... beta-2 Microglobulin ELISA Kits. Reliable ELISA kits for a wide range of species. ...
https://www.antikoerper-online.de/be/beta-2-microglobulin-53763/
RCSB PDB - 4E0L: FYLLYYT segment from human Beta 2 Microglobulin (62-68) displayed on 54-membered macrocycle scaffoldRCSB PDB - 4E0L: FYLLYYT segment from human Beta 2 Microglobulin (62-68) displayed on 54-membered macrocycle scaffold
FYLLYYT segment from human Beta 2 Microglobulin (62-68) displayed on 54-membered macrocycle scaffold ... Out-of-register beta-sheets suggest a pathway to toxic amyloid aggregates.. Liu, C., Zhao, M., Jiang, L., Cheng, P.N., Park, J. ... FYLLYYT segment from human Beta 2 Microglobulin (62-68) displayed on 54-membered macrocycle scaffold. *PDB DOI: 10.2210/pdb4E0L ... 4S)-2-METHYL-2,4-PENTANEDIOL. C6 H14 O2. SVTBMSDMJJWYQN-YFKPBYRVSA-N. Ligand Interaction. ...
https://www.rcsb.org/structure/4E0L
LOINC LG2806-0 - Beta-2-Microglobulin|SCnc|Pt|ANYBldSerPlLOINC LG2806-0 - Beta-2-Microglobulin|SCnc|Pt|ANYBldSerPl
LOINC Code LG2806-0 Beta-2-Microglobulin,SCnc,Pt,ANYBldSerPl ... Version 2.73 Beta. LG2806-0Beta-2-Microglobulin,. SCnc,. Pt,. ... Beta-2-Microglobulin [Moles/volume] in Serum or Plasma. LOINC Copyright. Copyright © 2022 Regenstrief Institute, Inc. All ...
https://loinc.org/loinc/LG2806-0/
Beta-2-microglobulin expression in the liver after liver transplantation. | Journal of Clinical PathologyBeta-2-microglobulin expression in the liver after liver transplantation. | Journal of Clinical Pathology
Using the "time zero" biopsy specimens as a baseline for comparison, increased expression of beta 2m was seen in bile ducts, ... beta 2m), a subunit of the class 1 antigen system. Paraffin wax sections were examined from 25 "time zero" biopsy specimens, ... class 1 antigens was studied in the liver after transplantation by immunoperoxidase staining for beta-2-microglobulin ( ...
https://jcp.bmj.com/content/41/10/1049
beta 2-Microglobulin - McMaster Experts
Noninvasive monitoring of renal transplant function by analysis of beta2-microglobulin Academic Article ...
https://experts.mcmaster.ca/display/vocab-mesh-beta-2-microglobulin
Purified Beta 2-Microglobulin Protein | AG65-0041-01-Z | Immunology Consultatnt LaboratoryPurified Beta 2-Microglobulin Protein | AG65-0041-01-Z | Immunology Consultatnt Laboratory
Purified Beta 2-Microglobulin Protein. Catalogue Numbre: AG65-0041-01-Z, Supplied by Immunology Consultatnt Laboratory& ... Purified Beta 2-Microglobulin Protein , AG65-0041-01-Z , Immunology Consultatnt Laboratory ... Purified Beta 2-Microglobulin Protein , AG65-0041-01-Z. Immunology Consultatnt Laboratory ... Purified Beta 2-Microglobulin Protein , AG65-0041-01-Z. Rating * Select Rating. 1 star (worst). 2 stars. 3 stars (average). 4 ...
https://tumori.net/purified-beta-2-microglobulin-protein-ag65-0041-01-z/
Beta-2 microglobulin in patients on peritoneal dialysis and hemodialysis<...
Beta-2 microglobulin in patients on peritoneal dialysis and hemodialysis. A. Scalamogna, E. Imbasciati, A. De Vecchi, C. ... Beta-2 microglobulin in patients on peritoneal dialysis and hemodialysis. / Scalamogna, A.; Imbasciati, E.; De Vecchi, A. et al ... N2 - Serum β2 microglobulin (β2μ) levels were determined in 62 patients on chronic dialysis, divided according to the type of ... AB - Serum β2 microglobulin (β2μ) levels were determined in 62 patients on chronic dialysis, divided according to the type of ...
https://moh-it.pure.elsevier.com/en/publications/beta-2-microglobulin-in-patients-on-peritoneal-dialysis-and-hemod
Beta 2-microglobulin elimination characteristics during hemofiltration with acrylonitrile and polysulfone membrane hemofilters<...
Elimination characteristics of beta 2 -microglobulin (BMG) during hemofiltration (HF) with acrylonitrile (AN69) and polysulfone ... Beta 2-microglobulin elimination characteristics during hemofiltration with acrylonitrile and polysulfone membrane hemofilters. ... Beta 2-microglobulin elimination characteristics during hemofiltration with acrylonitrile and polysulfone membrane hemofilters ... Beta 2-microglobulin elimination characteristics during hemofiltration with acrylonitrile and polysulfone membrane hemofilters ...
https://www.scholars.northwestern.edu/en/publications/beta-2-microglobulin-elimination-characteristics-during-hemofiltr
NHANES 1988-1994: ß-trace Protein & ß2 Microglobulin (Surplus) Data Documentation, Codebook, and Frequencies
SSBTP - Beta-trace protein (mg/L). Variable Name: SSBTP. SAS Label: Beta-trace protein (mg/L). English Text: Beta-trace protein ... β2 microglobulin was assayed using the N Latex β2 microglobulin assay, Siemens Diagnostics, IL. ... The effects of freeze-thaw on beta-trace protein and beta2-microglobulin assays after long-term sample storage. Clin Biochem. ... Beta-2 microglobulin (mg/L). English Text: Beta-2 microglobulin (mg/L). Target: Both males and females 12 YEARS - 90 YEARS. ...
https://wwwn.cdc.gov/nchs/data/nhanes3/36a/SSNH3BTP.htm
Citrate stabilized gold nanoparticles interfere with amyloid fibril formation: D76N and Delta N6 beta 2-microglobulin variants ...Citrate stabilized gold nanoparticles interfere with amyloid fibril formation: D76N and Delta N6 beta 2-microglobulin variants ...
Citrate stabilized gold nanoparticles interfere with amyloid fibril formation: D76N and Delta N6 beta 2-microglobulin variants ... Citrate stabilized gold nanoparticles interfere with amyloid fibril formation: D76N and Delta N6 beta 2-microglobulin variants ... Citrate stabilized gold nanoparticles interfere with amyloid fibril formation: D76N and Delta N6 beta 2-microglobulin variants ... were recently investigated with amyloidogenic protein β2-microglobulin (β2m). Here we present the computational studies on two ...
https://discovery.ucl.ac.uk/id/eprint/10051766/
BETA - 2 - MICROGLOBULIN, 24 HOUR URINE - Afriglobal Medicare | Best Medical diagnostics centre in NigeriaBETA - 2 - MICROGLOBULIN, 24 HOUR URINE - Afriglobal Medicare | Best Medical diagnostics centre in Nigeria
Additionally, this website uses cookies to improve your experience while you navigate through the website. Out of these, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may affect your browsing experience ...
https://afriglobalmedicare.com/medical-test/beta-2-microglobulin-24-hour-urine/
SYNLAB En: BETA 2-MICROGLOBULIN, CSFSYNLAB En: BETA 2-MICROGLOBULIN, CSF
2) Method (511) modification (16) Modifications (381) nemonic (9) New test (988) Notice (28) Reference values (1571) repor (1) ... Report (37) result format (35) Sample volume (1) Samples (333) Samples Restriction (28) Studied compounds (3) Studied Exons (2) ...
http://blog-en.labconous.com/2022/10/beta-2-microglobulin-csf.html
Beta-2 Microglobulin Antibody [SPM617] | NeoBiotechnologiesBeta-2 Microglobulin Antibody [SPM617] | NeoBiotechnologies
SPM617 is a Mouse Monoclonal Antibody to Beta-2 Microglobulin. Validated in Flow Cyt, IF, IHC-P. Reacts with Human. Non-Human ... Beta2 microglobulin is a 12KDa protein with a pI of 5.6. Serum beta2 microglobulin levels are a reflection of cell turnover. ... Beta chain of MHC class I molecules; Beta-2-microglobulin form pI 5.3; Hdcma22p. ... Beta-2 Microglobulin (Renal Failure & Tumor Marker). Mouse Monoclonal Antibody [Clone SPM617] Printable ...
https://www.neobiotechnologies.com/datasheet/beta2-microglobulin-antibody-spm617-567-2x
Comparison of serum concentrations of β-trace protein, β2-microglobulin, cystatin C, and creatinine in the US populationComparison of serum concentrations of β-trace protein, β2-microglobulin, cystatin C, and creatinine in the US population
... Clin J ... Background and objectives: β-trace protein (βTP), β2-microglobulin (β2M), and cystatin C (CysC) have advantages over creatinine ... beta 2-Microglobulin * Creatinine * Intramolecular Oxidoreductases * prostaglandin R2 D-isomerase Grant support * T32 HL007024/ ...
https://pubmed.ncbi.nlm.nih.gov/23335043/
Beta-2-Microglobulin, Serum - Ascend Reference ManualBeta-2-Microglobulin, Serum - Ascend Reference Manual
Ascend Reference Manual Copyright © 2022. All right reserved. ...
https://referencemanual.aclab.com/testarticle/beta-2-microglobulin-serum-test/
Rat beta-2-Microglobulin (B2M) Antibody | 11452-05011 | Universal BiologicalsRat beta-2-Microglobulin (B2M) Antibody | 11452-05011 | Universal Biologicals
Rat beta-2-Microglobulin (B2M) Antibody. Move your mouse over image or click to enlarge ... beta 2 Microglobulin, beta Chain of MHC Class 1 Proteins, Hdcma22p, CDABP0092, HDCMA22P, B2M ...
https://www.universalbiologicals.com/beta-2-microglobulin-anti-rat-igg-11452-05011
B Tests - HSE.ieB Tests - HSE.ie
Beta-D-Glucan. *Test Name: Beta-D-Glucan. *Laboratory: Serology External. *Specimen Type: Serum ... Turnaround Time: 2-4 days. *Phone alert limits: Group A streptococci isolates, new MRSA isolates from hospital in patients and ... Turnaround Time: 2-4 days. *Phone alert limits: Group B Streptococci isolates from all antenatal and post-natal in-patients, ... Identification and susceptibility within 2 days of growth.. *Phone alert limits: All positive gram stains/isolates are phoned ...
https://www.hse.ie/eng/services/list/3/acutehospitals/hospitals/waterford/laboratoryservices/b-tests.html
IMSEAR at SEARO: Suppression of beta 2 microglobulin by pentoxiphylline therapy in asymptomatic HIV infected individuals.
Mean levels of beta 2 M before therapy were 1.51 +/- 0.77 mg/l (range 0.78-3.8 mg/l) and were significantly higher (P , 0.001) ... Beta 2 microglobulin (beta 2 M) has been used as a surrogate marker to study the progression of HIV infection. The objective of ... beta 2 M was measured using an enzyme immunoassay before and four weeks after the start of treatment with pentoxiphylline. ... Wanchu A, Arora S, Bhatnagar A, Sud A, Bambery P, Singh S. Suppression of beta 2 microglobulin by pentoxiphylline therapy in ...
https://imsear.searo.who.int/handle/123456789/25325
Mouse Beta-2-Microglobulin (b2M) ELISA kit | Technique alternative | 01010506176 - Kamiyabio
Order Mouse Beta-2-Microglobulin b2M ELISA kit 01010506176 at Gentaur Beta-2-Microglobulin (b2M) ...
http://kamiyabio.com/shop-catalog/3332-kamiya/3765-mouse-beta-2-microglobulin-b2m-elisa-kit
Beta-2 Microglobulin Test in Hyderabad + Home Collection in 60 MinsBeta-2 Microglobulin Test in Hyderabad + Home Collection in 60 Mins
Book a Beta-2 Microglobulin test in Hyderabad, get tested at home in 60 mins with Orange Health- NABL & ICMR approved lab. Get ... What are the normal values for the Beta-2 Microglobulin test?. 1.1 - 2.4 mg/L. What is the type of sample required?. This test ... Is fasting required for a Beta-2 Microglobulin test?. Fasting is not required for this test. Any other precautions to be taken ... What is the cost of the Beta-2 Microglobulin test in Hyderabad?. The cost of the Beta-2 Microglobulin test in Hyderabad is Rs. ...
https://www.orangehealth.in/lab-tests-hyderabad/beta-2-microglobulin
Amyloidosis: Definition of Amyloid and Amyloidosis, Classification Systems, Systemic AmyloidosesAmyloidosis: Definition of Amyloid and Amyloidosis, Classification Systems, Systemic Amyloidoses
Beta-pleated sheet structure as observed by x-ray diffraction pattern Apple-green birefringence on Congo red histological sta ... Beta2-microglobulin amyloidosis ( Abeta2M). The precursor protein is a normal beta2 -microglobulin (β2 M), which is the light- ... The amyloid beta precursor protein (AβPP), which is a transmembrane glycoprotein, is the precursor protein in beta protein ... have substantial beta-pleated sheet structure, while extensive beta-sheet structure occurs in all of the deposited fibrils. ...
https://www.medscape.com/answers/335414-106030/what-is-the-role-of-beta-2m-adsorbing-columns-in-the-treatment-of-dialysis-related-amyloidosis
Abundant CD8+ tumor infiltrating lymphocytes and beta-2-microglobulin are associated with better outcome and response to...Abundant CD8+ tumor infiltrating lymphocytes and beta-2-microglobulin are associated with better outcome and response to...
keywords = "Beta-2-microglobulin, CD8, Clear cell renal cell carcinoma, Immunoscore, Interleukin 2, Outcome, TIL, Tumor ... Dive into the research topics of Abundant CD8+ tumor infiltrating lymphocytes and beta-2-microglobulin are associated with ... T1 - Abundant CD8+ tumor infiltrating lymphocytes and beta-2-microglobulin are associated with better outcome and response to ... Abundant CD8+ tumor infiltrating lymphocytes and beta-2-microglobulin are associated with better outcome and response to ...
https://ohsu.pure.elsevier.com/en/publications/abundant-cd8-tumor-infiltrating-lymphocytes-and-beta-2-microglobu
Analysis: Beta-2 microglobulin in urine | MVZ Dr. Eberhard & Partner Dortmund GbR (ÜBAG)Analysis: Beta-2 microglobulin in urine | MVZ Dr. Eberhard & Partner Dortmund GbR (ÜBAG)
The MVZ Dr. Eberhard & Partner Dortmund is specialised in the areas of laboratory medicine, microbiology, human genetics and endocrinology, both in a diagn...
https://www.medizin-zentrum-dortmund.de/en/laboratory-medicine/analyzes-directory/analysis/390/
Amyloidosis: Definition of Amyloid and Amyloidosis, Classification Systems, Systemic AmyloidosesAmyloidosis: Definition of Amyloid and Amyloidosis, Classification Systems, Systemic Amyloidoses
Beta-pleated sheet structure as observed by x-ray diffraction pattern Apple-green birefringence on Congo red histological sta ... Beta2-microglobulin amyloidosis ( Abeta2M). The precursor protein is a normal beta2 -microglobulin (β2 M), which is the light- ... The amyloid beta precursor protein (AβPP), which is a transmembrane glycoprotein, is the precursor protein in beta protein ... have substantial beta-pleated sheet structure, while extensive beta-sheet structure occurs in all of the deposited fibrils. ...
https://emedicine.medscape.com/article/335414
4f7c.2 | SWISS-MODEL Template Library
... entry for 4f7c.2. Crystal structure of bovine CD1d with bound C12-di-sulfatide ... 1 x NAG- NAG- BMA- BMA: beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2- ... 1 x 0SG: N-{(2S,3R,4E)-1-[(3,6-di-O-sulfo-beta-D-galactopyranosyl)oxy]-3-hydroxyoctadec-4-en-2-yl}dodecanamide(Non-covalent). ... 1 x NAG- NAG- BMA: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D- ...
https://swissmodel.expasy.org/templates/4f7c.2
ProteinBeta2-microglobulinSerumMouse Beta-2-MicroglobulAntibodyURINEMoleculesAntibodiesSurrogate markerAntigenAssayTumorProteinsPeptideSpeciesGeneAntigensAbstractAmyloidChainsMultiple myelomaInfectionHumanKidneyMicroglobulinaBloodLymphomaTurnaround TimePatientsCellsAnalysisLevelsYEARSForm0.06TherapyLiver0.27PresentTotalTest
Protein10
  • A beta-2 microglobulin tumor marker test measures the amount of a protein called beta-2 microglobulin (B2M) in your body fluids. (medlineplus.gov)
  • Mouse Beta-2-Microglobulin ELISA Kit (ab223590) is a single-wash 90 min sandwich ELISA designed for the quantitative measurement of Beta-2-Microglobulin protein in cell culture supernatant, cit plasma, edta plasma, hep plasma, serum, and urine. (abcam.com)
  • The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. (antikoerper-online.de)
  • Juraschek SP, Coresh J, Inker LA, Rynders GP, Eckfeldt JH, Selvin E. The effects of freeze-thaw on beta-trace protein and beta2-microglobulin assays after long-term sample storage. (cdc.gov)
  • In particular citrate-coated gold nanoparticles (cit-AuNPs) were recently investigated with amyloidogenic protein β2-microglobulin (β2m). (ucl.ac.uk)
  • Beta2 microglobulin is a 12KDa protein with a pI of 5.6. (neobiotechnologies.com)
  • β-trace protein (βTP), β2-microglobulin (β2M), and cystatin C (CysC) have advantages over creatinine for estimating GFR and prognosis. (nih.gov)
  • This test analyzes the amount of a protein called beta-2 microglobulin (B2M) in the blood, urine, or cerebrospinal fluid (CSF). (orangehealth.in)
  • Given fundamental interaction of MHC class I with CD8+ T-cells, we hypothesized that expression of MHC class I associated protein, beta-2-microglobulin (B2M), may be an important immunologic marker in RCC. (elsevier.com)
  • 2006) Esti- mation of benchmark dose as the threshold levels of urinary cadmium, based on excretion of total protein, beta2-microglobulin, and N-acetyl-beta-D-glucosemini- dase in cadmium nonpolluted regions in Japan. (scirp.org)
Beta2-microglobulin2
  • Serum beta2 microglobulin levels are a reflection of cell turnover. (neobiotechnologies.com)
  • Beta2 microglobulin levels can rise either because its rate of synthesis has increased (e.g. in AIDS, malignant monoclonal plasma cell dyscrasia, solid tumours and autoimmune disease) or because of impaired renal filtration (e.g. due to renal insufficiency, graft rejection or nephrotoxicity induced by post-transplantation immunosuppressive therapy). (neobiotechnologies.com)
Serum2
  • Serum β2 microglobulin (β2μ) levels were determined in 62 patients on chronic dialysis, divided according to the type of dialysis - cuprophane hemodialysis, chronic ambulatory peritoneal dialysis (CAPD), or CAPD started after 76 ± 47 months on cuprophane hemodialysis - and to residual urine output greater than 400 mL/day or less than 10 mL/day. (elsevier.com)
  • Beta 2-microglobulin is present in small amounts in serum, CEREBROSPINAL FLUID , and urine of healthy individuals, and to a much greater degree in the urine and plasma of patients with tubular PROTEINURIA , renal failure, or kidney transplants. (bvsalud.org)
Mouse Beta-2-Microglobul1
  • Quantitate Mouse Beta-2-Microglobulin with 1.165 pg/ml sensitivity. (abcam.com)
Antibody2
  • The section was stained using β2 Microglobulin Antibody, anti-human, PE (green) for 10 min at room temperature (A). β2 Microglobulin Antibody, anti-human, PE staining was released using the REAlease Release Reagent (B). Nuclei were visualized with Hoechst™ (blue). (miltenyibiotec.com)
  • Clone REAL845 is an antibody fragment derived from the full β2 Microglobulin antibody molecule. (miltenyibiotec.com)
URINE1
  • 2005) The threshold cadmium level that causes a substantial increase in ?2-microglobulin in urine of general populations. (scirp.org)
Molecules1
  • The CD85J/leukocyte inhibitory receptor-1 distinguishes between conformed and beta 2-microglobulin-free HLA-G molecules. (ox.ac.uk)
Antibodies1
  • An antigenic determinant of human beta 2-microglobulin masked by the association with HLA heavy chains at the cell surface: analysis using monoclonal antibodies. (neobiotechnologies.com)
Surrogate marker2
  • Beta 2 microglobulin (beta 2 M) has been used as a surrogate marker to study the progression of HIV infection. (who.int)
  • Beta-2 microglobulin is a surrogate marker for the overall body tumor burden. (medscape.com)
Antigen1
  • The distribution of major histocompatibility complex (MHC) class 1 antigens was studied in the liver after transplantation by immunoperoxidase staining for beta-2-microglobulin (beta 2m), a subunit of the class 1 antigen system. (bmj.com)
Assay1
  • β2 microglobulin was assayed using the N Latex β2 microglobulin assay, Siemens Diagnostics, IL. (cdc.gov)
Tumor6
  • What is a beta-2 microglobulin tumor marker test? (medlineplus.gov)
  • A beta-2 microglobulin tumor marker test can't diagnose cancer or any other condition. (medlineplus.gov)
  • A beta-2 microglobulin tumor marker test is most often used if you have been diagnosed with certain cancers of the bone marrow or blood. (medlineplus.gov)
  • Why do I need a beta-2 microglobulin tumor marker test? (medlineplus.gov)
  • We sought to understand potential implications of CD8 + TILs and tumor B2M expression on overall survival and response to high-dose interleukin-2 (IL-2) therapy, in a cohort of patients with high-stage (clinical stage III and IV) ccRCC. (elsevier.com)
  • In conclusion, abundant CD8+ TILs and high tumor expression of beta-2-microglobulin were good prognostic indicators associated with longer survival in patients with high-stage ccRCC. (elsevier.com)
Proteins2
  • During glomerular filtration (Fig. 2 ), blood plasma is filtered in the glomerulus, a bundle of porous capillaries lined by a membrane and specialized epithelial cells, that allows solutes and waste, including drugs and their metabolites, and water to pass through while ensuring larger substances, such as blood cells and proteins, remain in the circulatory system (Holechek 2003 ). (springer.com)
  • Megalin and cubilin receptors at the apical membrane are responsible for endocytosis-mediated reuptake of filtered low-molecular-weight proteins, such as β2-microglobulin (Eshbach and Weisz 2017 ). (springer.com)
Peptide2
  • Beta-2-Microglobulin is involved in the presentation of peptide antigens to the immune system. (abcam.com)
  • β2 microglobulin plays a role in the presentation of peptide antigens to the immune system. (miltenyibiotec.com)
Species1
  • Figure 2: Distinct commensal species impose specific immune signatures in the skin. (nature.com)
Gene1
  • The HFE gene, together with other biologically active compounds, regulates the intestinal absorption of iron [ 1 , 2 ]. (cdc.gov)
Antigens2
  • Expression of HLA-A, -B, and -C and beta 2-microglobulin antigens in human choriocarcinoma cell lines. (ox.ac.uk)
  • It may be concluded that the lack of expression of HLA-ABC antigens in choriocarcinoma (and in the trophoblast) is not a result of lack of beta 2-microglobulin, as is the case for the Burkitt's lymphoma cell line, Daudi. (ox.ac.uk)
Abstract1
  • abstract = "Elimination characteristics of beta 2 -microglobulin (BMG) during hemofiltration (HF) with acrylonitrile (AN69) and polysulfone (PS) hemofilters were investigated in a prospective clinical investigation. (northwestern.edu)
Amyloid1
  • [ 2 ] Many classic eponymic diseases were later found to be related to a diverse array of misfolded polypeptides (amyloid) that contain the common beta-pleated sheet architecture. (medscape.com)
Chains1
  • Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. (bvsalud.org)
Multiple myeloma1
  • β2 microglobulin is a positive marker for multiple myeloma and lymphoma, rheumatoid arthritis, systemic lupus erythematosus, and for inflammatory disorders and viral infections, including HIV and CMV. (miltenyibiotec.com)
Infection1
  • The past 2 years have witnessed remarkable advances in the development of antiretroviral therapy (ART) for human immunodeficiency virus (HIV) infection, as well as measurement of HIV plasma RNA (viral load) to guide the use of antiretroviral drugs. (cdc.gov)
Human2
  • found in human fecal samples in low percentages ( 2 - 7 ). (cdc.gov)
  • Immunoprecipitation of [35S]methionine-labeled cell extracts and analysis by sodium dodecyl sulfate-polyacrylamide gel electrophoresis showed that cells from two human choriocarcinomas JaR and BeWo contained beta 2-microglobulin. (ox.ac.uk)
Kidney1
  • Rediscovering beta-2 microglobulin as a biomarker across the spectrum of kidney diseases. (medigraphic.com)
Microglobulina3
  • β-2 microglobulina como marcador de IRA en pacientes obst tricas. (medigraphic.com)
  • Generalmente se requiere la asociación con la microglobulina beta-2 para el transporte de cadenas pesadas de clase I desde el retículo endoplásmico a la superficie celular. (bvsalud.org)
  • La microglobulina beta-2 está presente en pequeñas cantidades en el suero, el LÍQUIDO CEFALORRAQUÍDEO y la orina de las personas sanas y, en grado mucho mayor, en la orina y el plasma de los pacientes con PROTEINURIA tubular o insuficiencia renal y en receptores de trasplante de riñón. (bvsalud.org)
Blood3
  • A beta-2 microglobulin test usually uses a sample of your blood. (medlineplus.gov)
  • The Beta-2 Microglobulin test: Analyzes the levels of beta-2 microglobulin in the blood. (orangehealth.in)
  • β2 microglobulin is a component of the class I major histocompatibility complex (MHC), which is located on all nucleated cells, excluding red blood cells. (miltenyibiotec.com)
Lymphoma2
  • Angioimmunoblastic T-cell lymphoma is characterised histologically by a polymorphous infiltrate primarily involving lymph nodes , a proliferation of high endothelial venules , and follicular dendritic cells [2]. (dermnetnz.org)
  • Angioimmunoblastic T-cell lymphoma accounts for 15-20% of peripheral T-cell lymphomas and 1-2% of non-Hodgkin lymphomas [2,4]. (dermnetnz.org)
Turnaround Time1
  • Turnaround Time: Routine - 2 working days. (hse.ie)
Patients3
  • Information was collected from patients' charts on a standardised form in 1991-2 under the supervision of the coordinating centre (University of Copenhagen). (bmj.com)
  • The level of beta-2 microglobulin is increased in patients with renal insufficiency without MM, which is one reason that it is a useful prognosticator in MM. (medscape.com)
  • METHODS: We used electronic health records for asthma patients aged 2-17 years from a regional, urban, children's hospital in Ohio during 2011-2015. (cdc.gov)
Cells1
  • Using the "time zero" biopsy specimens as a baseline for comparison, increased expression of beta 2m was seen in bile ducts, hepatocytes, and endothelial cells after transplantation. (bmj.com)
Analysis4
  • Western Blot Analysis of THP-1 and Raji Cell lysate using Beta-2-Microglobulin MAb (SPM617). (neobiotechnologies.com)
  • 2 Department of Clinical Analysis. (isciii.es)
  • Sample collection, handling, and analysis were performed under the ethical protocols H-2-2012-FSP2 (Regional Committee on Health Research Ethics) and case no. 1304226 (National Committee on Health Research Ethics). (cdc.gov)
  • BLASTn analysis initially identified 8 contigs aligning to bufavirus-1 or 2. (cdc.gov)
Levels2
  • The objective of this study was to see if use of pentoxiphylline resulted in any decline in beta 2 M levels. (who.int)
  • Use of pentoxiphylline for four weeks results in a significant decline in the levels of beta 2 M suggesting that the level of immune activation is reduced with the therapy. (who.int)
YEARS2
  • The venetoclax actually was only for 2 years. (targetedonc.com)
  • And so one may be able to use that information in a patient that is high-risk such as this and say, do we end it at 2 years? (targetedonc.com)
Form1
  • We have not detected any homozygous cases, and the heterozygous form is present in 2% of the population. (cdc.gov)
0.061
  • On multivariable analyses, tumors with a combination of both high B2M expression and high CD8 + TILs also showed trend to responding to IL-2 therapy (coef: 2.5, p = 0.06). (elsevier.com)
Therapy4
  • IMSEAR at SEARO: Suppression of beta 2 microglobulin by pentoxiphylline therapy in asymptomatic HIV infected individuals. (who.int)
  • Wanchu A, Arora S, Bhatnagar A, Sud A, Bambery P, Singh S. Suppression of beta 2 microglobulin by pentoxiphylline therapy in asymptomatic HIV infected individuals. (who.int)
  • Within the subgroup treated with IL-2 (n = 27, 48%), tumors with high CD8 + TILs were more likely to respond to IL-2 therapy [coefficient (coef): 1.6, p = 0.05]. (elsevier.com)
  • Abundant CD8+ TILs may predict response to IL-2 therapy. (elsevier.com)
Liver1
  • Beta-2-microglobulin expression in the liver after liver transplantation. (bmj.com)
0.271
  • Bufaviruses are gastroenteritis, and in only 0.27%-4% of samples ( 2 - 8 ). (cdc.gov)
Present1
  • In the present study, we demonstrate that HLA-G must associate with beta(2)m for its interaction with CD85J/leukocyte Ig-like receptor-1 (LIR-1). (ox.ac.uk)
Total1
  • DNase buffer in a total volume of 400 µL, and incubated at 37°C for 2 h. (cdc.gov)
Test9
  • What is the Beta-2 Microglobulin test? (orangehealth.in)
  • When is the Beta-2 Microglobulin test recommended? (orangehealth.in)
  • How often should I get the Beta-2 Microglobulin test? (orangehealth.in)
  • The Beta-2 Microglobulin test is prescribed by your doctor after completing the assessment of your condition. (orangehealth.in)
  • What are the normal values for the Beta-2 Microglobulin test? (orangehealth.in)
  • Is fasting required for a Beta-2 Microglobulin test? (orangehealth.in)
  • Any other precautions to be taken before getting myself tested for a Beta-2 Microglobulin test? (orangehealth.in)
  • How can I book a Beta-2 Microglobulin test in Hyderabad? (orangehealth.in)
  • Why should I book a Beta-2 Microglobulin test with Orange Health in Hyderabad? (orangehealth.in)
(emedicine.medscape.com)
Amyloidosis: Definition of Amyloid and Amyloidosis, Classification Systems, Systemic Amyloidoses
Amyloidosis: Definition of Amyloid and Amyloidosis, Classification Systems, Systemic Amyloidoses (medscape.com)
Tumor Marker Tests: MedlinePlus Medical Test
Tumor Marker Tests: MedlinePlus Medical Test (medlineplus.gov)
Membranous Glomerulonephritis: Practice Essentials, Pathophysiology, Epidemiology
Membranous Glomerulonephritis: Practice Essentials, Pathophysiology, Epidemiology (medscape.com)
Dialysis-Related Beta-2m Amyloidosis Clinical Presentation: History, Physical Examination
Dialysis-Related Beta-2m Amyloidosis Clinical Presentation: History, Physical Examination (medscape.com)
Chronic Kidney Disease (CKD): Practice Essentials, Pathophysiology, Etiology
Chronic Kidney Disease (CKD): Practice Essentials, Pathophysiology, Etiology (medscape.com)
Chronic Lymphocytic Leukemia (CLL): Practice Essentials, Pathophysiology, Etiology
Chronic Lymphocytic Leukemia (CLL): Practice Essentials, Pathophysiology, Etiology (medscape.com)
Waldenstrom Macroglobulinemia Guidelines: Guidelines Summary
Waldenstrom Macroglobulinemia Guidelines: Guidelines Summary (emedicine.medscape.com)
Leukemia | MedlinePlus
Leukemia | MedlinePlus (medlineplus.gov)
Light Chain-Associated Renal Disorders: Practice Essentials, Pathophysiology, Etiology
Light Chain-Associated Renal Disorders: Practice Essentials, Pathophysiology, Etiology (medscape.com)
Lymphoma | Hodgkins Lymphoma | Non Hodgkins Lymphoma | MedlinePlus
Lymphoma | Hodgkins Lymphoma | Non Hodgkins Lymphoma | MedlinePlus (medlineplus.gov)
Multiple Myeloma | Myeloma | Multiple Myeloma Symptoms | MedlinePlus
Multiple Myeloma | Myeloma | Multiple Myeloma Symptoms | MedlinePlus (medlineplus.gov)
4f7c.2 | SWISS-MODEL Template Library
4f7c.2 | SWISS-MODEL Template Library (swissmodel.expasy.org)
Multiple Myeloma Staging: Classification for Multiple Myeloma
Multiple Myeloma Staging: Classification for Multiple Myeloma (emedicine.medscape.com)
Beta2 Microglobulin: Reference Range, Interpretation, Collection and Panels
Beta2 Microglobulin: Reference Range, Interpretation, Collection and Panels (emedicine.medscape.com)
Kidney-based in vitro models for drug-induced toxicity testing | SpringerLink
Kidney-based in vitro models for drug-induced toxicity testing | SpringerLink (link.springer.com)
1D PFV: 4E0L
1D PFV: 4E0L (rcsb.org)
RCSB PDB - 4E0L: FYLLYYT segment from human Beta 2 Microglobulin (62-68) displayed on 54-membered macrocycle scaffold
RCSB PDB - 4E0L: FYLLYYT segment from human Beta 2 Microglobulin (62-68) displayed on 54-membered macrocycle scaffold (rcsb.org)
Multiple Myeloma Workup: Approach Considerations, Blood Studies, Urine Collection
Multiple Myeloma Workup: Approach Considerations, Blood Studies, Urine Collection (medscape.com)