A form of pneumoconiosis caused by inhaled rare metal BERYLLIUM or its soluble salts which are used in a wide variety of industry including alloys, ceramics, radiographic equipment, and vacuum tubes. Berylliosis is characterized by an acute inflammatory reaction in the upper airway leading to BRONCHIOLITIS; PULMONARY EDEMA; and pneumonia.
Beryllium. An element with the atomic symbol Be, atomic number 4, and atomic weight 9.01218. Short exposure to this element can lead to a type of poisoning known as BERYLLIOSIS.
A group of the D-related HLA antigens (human) found to differ from the DR antigens in genetic locus and therefore inheritance. These antigens are polymorphic glycoproteins comprising alpha and beta chains and are found on lymphoid and other cells, often associated with certain diseases.
Calamities producing great damage, loss of life, and distress. They include results of natural phenomena and man-made phenomena. Normal conditions of existence are disrupted and the level of impact exceeds the capacity of the hazard-affected community.
Any of several South American shrubs of the Erythroxylon genus (and family) that yield COCAINE; the leaves are chewed with alum for CNS stimulation.
Procedures outlined for the care of casualties and the maintenance of services in disasters.
Branch of medicine concerned with the prevention and control of disease and disability, and the promotion of physical and mental health of the population on the international, national, state, or municipal level.
The exchange or transmission of ideas, attitudes, or beliefs between individuals or groups.
Epidemics of infectious disease that have spread to many countries, often more than one continent, and usually affecting a large number of people.
The interactions between members of a community and representatives of the institutions within that community.

Differential susceptibilities to chronic beryllium disease contributed by different Glu69 HLA-DPB1 and -DPA1 alleles. (1/92)

Chronic beryllium disease (CBD) is associated with the allelic substitution of a Glu69 in the HLA-DPB1 gene. Although up to 97% of CBD patients may have the Glu69 marker, about 30-45% of beryllium-exposed, unaffected individuals carry the same marker. Because CBD occurs in only 1-6% of exposed workers, the presence of Glu69 does not appear to be the sole genetic factor underlying the disease development. Using two rounds of direct automated DNA sequencing to precisely assign HLA-DPB1 haplotypes, we have discovered highly significant Glu69-containing allele frequency differences between the CBD patients and a beryllium-exposed, nondiseased control group. Individuals with DPB1 Glu69 in both alleles were almost exclusively found in the CBD group (6/20) vs the control group (1/75). Whereas most Glu69 carriers from the control group had a DPB1 allele *0201 (68%), most Glu69 carriers from the CBD group had a non-*0201 DPB1 Glu69-carrying allele (84%). The DPB1 allele *0201 was almost exclusively (29/30) associated with DPA1 *01 alleles, while the non-*0201 Glu69-containing DPB1 alleles were closely associated with DPA1 *02 alleles (26/29). Relatively rare Glu69-containing alleles *1701, *0901, and *1001 had extremely high frequencies in the CBD group (50%), as compared with the control group (6.7%). Therefore, the most common Glu69-containing DPB1 allele, *0201, does not seem to be a major disease allele. The results suggest that it is not the mere presence of Glu69, per se, but specific Glu69-containing alleles and their copy number (homozygous or heterozygous) that confer the greatest susceptibility to CBD in exposed individuals.  (+info)

Partial IL-10 inhibition of the cell-mediated immune response in chronic beryllium disease. (2/92)

Chronic beryllium disease (CBD) provides a human disorder in which to study the delayed type IV hypersensitivity response to persistent Ag that leads to noncaseating pulmonary granuloma formation. We hypothesized that, in CBD, failure of IL-10 to modulate the beryllium-specific, cell-mediated immune response would result in persistent, maximal cytokine production and T lymphocyte proliferation, thus contributing to the development of granulomatous lung disease. To test this hypothesis, we used bronchoalveolar lavage cells from control and CBD subjects to evaluate the beryllium salt-specific production of endogenous IL-10 and the effects of exogenous human rIL-10 (rhIL-10) on HLA expression, on the production of IL-2, IFN-gamma, and TNF-alpha, and on T lymphocyte proliferation. Our data demonstrate that beryllium-stimulated bronchoalveolar lavage cells produce IL-10, and the neutralization of endogenous IL-10 does not increase significantly cytokine production, HLA expression, or T lymphocyte proliferation. Second, the addition of excess exogenous rhIL-10 partially inhibited the beryllium-stimulated production of IL-2, IFN-gamma, and TNF-alpha; however, we measured no change in T lymphocyte proliferation or in the percentage of alveolar macrophages expressing HLA-DP. Interestingly, beryllium salts interfered with an IL-10-stimulated decrease in the percentage of alveolar macrophages expressing HLA-DR. We conclude that, in the CBD-derived, beryllium-stimulated cell-mediated immune response, low levels of endogenous IL-10 have no appreciable effect; exogenous rhIL-10 has a limited effect on cytokine production and no effect on T lymphocyte proliferation or HLA expression.  (+info)

Chronic beryllium disease and cancer risk estimates with uncertainty for beryllium released to the air from the Rocky Flats Plant. (3/92)

Beryllium was released into the air from routine operations and three accidental fires at the Rocky Flats Plant (RFP) in Colorado from 1958 to 1989. We evaluated environmental monitoring data and developed estimates of airborne concentrations and their uncertainties and calculated lifetime cancer risks and risks of chronic beryllium disease to hypothetical receptors. This article discusses exposure-response relationships for lung cancer and chronic beryllium disease. We assigned a distribution to cancer slope factor values based on the relative risk estimates from an occupational epidemiologic study used by the U.S. Environmental Protection Agency (EPA) to determine the slope factors. We used the regional atmospheric transport code for Hanford emission tracking atmospheric transport model for exposure calculations because it is particularly well suited for long-term annual-average dispersion estimates and it incorporates spatially varying meteorologic and environmental parameters. We accounted for model prediction uncertainty by using several multiplicative stochastic correction factors that accounted for uncertainty in the dispersion estimate, the meteorology, deposition, and plume depletion. We used Monte Carlo techniques to propagate model prediction uncertainty through to the final risk calculations. We developed nine exposure scenarios of hypothetical but typical residents of the RFP area to consider the lifestyle, time spent outdoors, location, age, and sex of people who may have been exposed. We determined geometric mean incremental lifetime cancer incidence risk estimates for beryllium inhalation for each scenario. The risk estimates were < 10(-6). Predicted air concentrations were well below the current reference concentration derived by the EPA for beryllium sensitization.  (+info)

Association of man-made mineral fibre exposure and sarcoidlike granulomas. (4/92)

It is assumed that sarcoidosis is caused by inhalation of air borne agents in susceptible persons triggering the inflammatory reaction. The association of metallic dust exposure, such as beryllium and aluminium, and sarcoidlike pulmonary disorders is well known. The ability of man-made mineral fibres (MMMF) to cause granulomatous lung disease has not been appreciated until now. Recently, we observed the association of sarcoidlike granulomatous reaction and occupational history of glass fibre exposure. We hypothesized that there might be a relationship between MMMF exposure and the development of sarcoidlike granulomas. Therefore, the records of 50 sarcoidosis patients-who visited our outpatient clinic between 1996 and 1999 were reviewed. This revealed that 14 cases recalled a history of exposure to either glass fibres or rock wool, both MMMF fibres. The available obtained tissue specimens (n = 12) were reviewed. In six cases electron microscopy qualitative analysis of small fragments of the tissue revealed among others silica, aluminium and sometimes titanium. A distinct relation between fibre deposits fibre deposits and granulomas was found. These findings indicate that in susceptible people MMMF exposure might be related to a chronic granulomatous disease similar to chronic beryllium disease.  (+info)

Government laboratory worker with lung cancer: comparing risks from beryllium, asbestos, and tobacco smoke. (5/92)

Occupational medicine physicians are frequently asked to establish cancer causation in patients with both workplace and non-workplace exposures. This is especially difficult in cases involving beryllium for which the data on human carcinogenicity are limited and controversial. In this report we present the case of a 73-year-old former technician at a government research facility who was recently diagnosed with lung cancer. The patient is a former smoker who has worked with both beryllium and asbestos. He was referred to the University of California, San Francisco, Occupational and Environmental Medicine Clinic at San Francisco General Hospital for an evaluation of whether past workplace exposures may have contributed to his current disease. The goal of this paper is to provide an example of the use of data-based risk estimates to determine causation in patients with multiple exposures. To do this, we review the current knowledge of lung cancer risks in former smokers and asbestos workers, and evaluate the controversies surrounding the epidemiologic data linking beryllium and cancer. Based on this information, we estimated that the patient's risk of lung cancer from asbestos was less than his risk from tobacco smoke, whereas his risk from beryllium was approximately equal to his risk from smoking. Based on these estimates, the patient's workplace was considered a probable contributing factor to his development of lung cancer.  (+info)

Beryllium presentation to CD4+ T cells underlies disease-susceptibility HLA-DP alleles in chronic beryllium disease. (6/92)

Chronic beryllium disease results from beryllium exposure in the workplace and is characterized by CD4(+) T cell-mediated inflammation in the lung. Susceptibility to this disease is associated with particular HLA-DP alleles. We isolated beryllium-specific T cell lines from the lungs of affected patients. These CD4(+) T cell lines specifically responded to beryllium in culture in the presence of antigen-presenting cells that expressed class II MHC molecules HLA-DR, -DQ, and -DP. The response to beryllium was nearly completely and selectively blocked by mAb to HLA-DP. Additional studies showed that only certain HLA-DP alleles allowed presentation of beryllium. Overall, the DP alleles that presented beryllium to disease-specific T cell lines match those implicated in disease susceptibility, providing a mechanism for this association. Based on amino acid residues shared by these restricting and susceptibility DP alleles, our results provide insight into the residues of the DP beta-chain required for beryllium presentation.  (+info)

HLA-DP allele-specific T cell responses to beryllium account for DP-associated susceptibility to chronic beryllium disease. (7/92)

Occupational exposure to small molecules, such as metals, is frequently associated with hypersensitivity reactions. Chronic beryllium (Be) disease (CBD) is a multisystem granulomatous disease that primarily affects the lung, and occurs in approximately 3% of individuals exposed to this element. Immunogenetic studies have demonstrated a strong association between CBD and possession of alleles of HLA-DP containing glutamic acid (Glu) at position 69 in the HLA-DP beta-chain. T cell clones were raised from three patients with CBD in whom exposure occurred 10 and 30 years previously. Of 25 Be-specific clones that were obtained, all were restricted by HLA-DP alleles with Glu at DP beta69. Furthermore, the proliferative responses of the clones were absolutely dependent upon DP beta Glu(69) in that a single amino acid substitution at this position abolished the response. As befits a disease whose pathogenesis involves a delayed type hypersensitivity response, the large majority of Be-specific clones secreted IFN-gamma (Th1) and little or no IL-4 (Th2) cytokines. This study provides insights into the molecular basis of DP2-associated susceptibility to CBD.  (+info)

IL-4 fails to regulate in vitro beryllium-induced cytokines in berylliosis. (8/92)

Bronchoalveolar lavage (BAL) cells from patients with chronic beryllium disease (CBD) have been used to evaluate the beryllium-specific immune response and potential immunotherapeutics. Beryllium induces interferon-gamma (IFN-gamma), interleukin-2 (IL-2), tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-10 (IL-10) from BAL cells. An antibody to IL-2 and recombinant human (rHu) IL-10 is able to partially suppress the beryllium-stimulated immune response. To obtain BAL cells, bronchoscopy is required, providing risk to the patient and a limited number of cells to study the immune response. As a result, the objectives of the study were to determine 1) whether CBD peripheral blood mononuclear cells (PBMNs) stimulated with beryllium would produce a similar cytokine pattern as BAL cells, and 2) whether this response could be modulated by interleukin-4 (IL-4), an immunomodulatory cytokine. CBD and normal individuals' PBMN and BAL cells were stimulated with and without beryllium sulfate. To modulate this antigen-stimulated response, we added rHu IL-4 to the unstimulated and beryllium-stimulated cells. IFN-gamma, IL-2, TNF-alpha, IL-6 and IL-10 cytokine concentrations were determined from cell supernatants by enzyme-linked immunosorbent assays (ELISA), while IL-4 messenger ribonucleic acid (mRNA) was assessed using polymerase chain reaction (PCR). Beryllium did not stimulate any of these cytokines from normal PBMNs. Increasing levels of IL-6 and TNF-alpha were produced constituitively by CBD PBMNs over time. Compared to the unstimulated CBD PBMNs, beryllium stimulated significant IFN-gamma, TNF-alpha, IL-2, IL-6 and IL-10 production. This response was similar to that stimulated from CBD BAL cells, although of a much lower magnitude. Low levels of IL-4 mRNA were found in CBD and control PBMNs, which were not increased with beryllium stimulation. The beryllium-stimulated cytokine levels were not decreased by the addition of IL-4. IL-4 was unable to downregulate any of these beryllium-stimulated cytokines from CBD BAL cells or increase IL-4 mRNA from either CBD PBMN or BAL cells, and thus is an unlikely immunomodulatory agent in CBD. From the data, it was concluded that chronic beryllium disease peripheral blood mononuclear cells provide a model to study the beryllium-stimulated immune response. Interleukin-4's inability to downregulate any of the beryllium-stimulated cytokines makes it an unlikely therapeutic candidate in chronic beryllium disease.  (+info)

Berylliosis is characterized by inflammation and scarring in the lungs, which can lead to shortness of breath, coughing, and fatigue. It can also cause lung collapse and respiratory failure. In severe cases, berylliosis can be fatal.

The symptoms of berylliosis can vary depending on the extent of exposure to beryllium, the duration of exposure, and individual susceptibility. Some people may experience mild symptoms, while others may develop more severe disease.

Berylliosis is diagnosed through a combination of medical history, physical examination, lung function tests, and imaging studies such as chest X-rays or CT scans. There is no cure for berylliosis, but treatment options include medications to manage symptoms and slow the progression of the disease, as well as pulmonary rehabilitation.

Prevention is key in avoiding berylliosis, and this includes minimizing exposure to beryllium in workplaces and ensuring proper ventilation and safety measures. Workers handling beryllium should wear protective gear such as masks and gloves, and employers must adhere to strict safety protocols to prevent exposure.

In summary, berylliosis is a serious lung disease caused by exposure to beryllium, with symptoms ranging from mild to severe. Diagnosis is based on a combination of medical history, physical examination, and imaging studies, and treatment involves managing symptoms and slowing the progression of the disease. Prevention is crucial in avoiding berylliosis, which includes minimizing exposure to beryllium in workplaces and ensuring proper ventilation and safety measures.

Findings on CT are also not specific to berylliosis. Findings that are common in CT scans of people with berylliosis include ... Some studies suggest that up to 6% of all cases of sarcoidosis are actually berylliosis. Definitive diagnosis of berylliosis is ... Berylliosis is an occupational lung disease. While there is no cure, symptoms can be treated. With single or prolonged exposure ... Berylliosis, or chronic beryllium disease (CBD), is a chronic allergic-type lung response and chronic lung disease caused by ...
By the 1996, the US Department of Energy identified more than 50 cases of chronic berylliosis among nuclear industry employees ... Machining the tamper shells produces beryllium and beryllium oxide dust; its inhalation can cause berylliosis. ...
Berylliosis causes pneumonia and other associated respiratory illness. Beryllium is a steel gray and hard metal that is brittle ... Chronic berylliosis is a pulmonary and systemic granulomatous disease caused by inhalation of dust or fumes contaminated with ... Chronic berylliosis resembles sarcoidosis in many respects, and the differential diagnosis is often difficult. It killed some ... Because of this, inhalation of beryllium metal dust by people leads to the development of the fatal condition of berylliosis. ...
She discovered that many of the workers contracted berylliosis. Berylliosis is caused by the inhalation of dust or fumes ...
Many conditions can cause Schaumann bodies, including: Sarcoidosis, Hypersensitivity pneumonitis, and Berylliosis. uncommonly, ...
Chronic berylliosis is a pulmonary and systemic granulomatous disease caused by exposure to beryllium. Between 1% - 15% of ... called chronic beryllium disease or berylliosis. The body's immune system recognises the beryllium as foreign particles and ...
The LTT for beryllium is now accepted as the gold standard for diagnosing berylliosis. MELISA differs from standard LTTs in ...
It is known to be highly reactive and extremely toxic and can cause berylliosis. The Be2+ cation is characterized by the ...
Berylliosis is associated with exposure to beryllium in the beryllium mining, aerospace and manufacturing industries. Chronic ...
BeO is carcinogenic in powdered form and may cause a chronic allergic-type lung disease berylliosis. Once fired into solid form ...
... berylliosis Some plants contain glycosides of 1,25-dihydroxycholecalciferol. Consumption of these glycosides by grazing animals ...
... may be used to distinguish sarcoidosis from conditions with otherwise indistinguishable symptoms such as berylliosis ...
... and is distinct from berylliosis (also called chronic beryllium disease). After occupational safety procedures were put into ... place following the realization that the metal caused berylliosis around 1950, acute beryllium poisoning became extremely rare ...
His death was caused by lung failure, a derivative result of berylliosis-chronic beryllium poisoning, which he contracted ... returned there in 1978 as a fellow and then a senior fellow until his death from an almost forty-year struggle with berylliosis ...
He died at age 39 in Palo Alto, California of berylliosis and fibrosis of the lungs, caused by inhaling the beryllium used in ...
... which are calcium-containing inclusion bodies found in the cytoplasm of giant cells in sarcoidosis and berylliosis. Schaumann ...
Conglomerate masses may also occur in other pneumoconioses, such as talcosis, berylliosis (CBD), kaolin pneumoconiosis, and ...
Pneumoconiosis Asbestosis Baritosis Bauxite fibrosis Berylliosis Caplan's syndrome Chalicosis Coalworker's pneumoconiosis ( ...
Aplastic anemia Asbestosis Berylliosis Byssinosis Hodgkins disease Interstitial lung disease Leukemia Lymphoma Manganism ...
... monosomy 2q duplication 1p Chronic berylliosis Chronic bronchitis Chronic demyelinizing neuropathy with IgM monoclonal Chronic ...
Malignancy Lymphoma Carcinoma Mediastinal tumors Inorganic dust disease Silicosis Berylliosis Extrinsic allergic alveolitis ...
... berylliosis) Pneumoconiosis (coal-worker's) A CHEST Arrhythmia/altered conscious level Cyanosis, PaCO2 normal Hypotension, ...
... or berylliosis, usually as a result of long-term exposure to beryllium oxide usually caused by inhalation. This article ...
... berylliosis MeSH C08.381.483.600.275 - byssinosis MeSH C08.381.483.600.300 - caplan's syndrome MeSH C08.381.483.600.750 - ...
... and cerebral calcification Berylliosis Beta ketothiolase deficiency Beta-galactosidase-1 deficiency Beta-mannosidosis Beta- ...
... bauxite Berylliosis - beryllium Siderosis - iron Byssinosis - Byssinosis is caused by cotton dust inhalation and typically ...
... berylliosis, byssinosis, coal dust pneumoconiosis, farmers' lung, hard metal pneumoconiosis, pleural and peritoneal ...
... berylliosis, histoplasmosis, Crohn's disease, and granulomatosis with polyangiitis) Idiopathic hypercalcaemia of infancy ...
Examples of non-infectious granulomatous diseases are sarcoidosis, Crohn's disease, berylliosis, giant-cell arteritis, ...
... phlebitis of the portal vein granulomatous hepatitis berylliosis sarcoidosis nonalcoholic steatohepatitis (NASH) This may cause ...
Berylliosis. * Graphite fibrosis (of lung) 516.0 Pneumoconiosis due to other inorganic dust *Aluminosis (of lung) ...
Asbestosis and berylliosis also were diagnosed. Case 3. In November 1992, a man aged 67 years in New Jersey died 3 days after ... Asbestosis is caused by exposure to asbestos, once commonly used in dental laboratories; berylliosis is caused by exposure to ...
IL-4 fails to regulate in vitro beryllium-induced cytokines in berylliosis. Eur Respir J 17(3):403-15. ... Interaction of genetic and exposure factors in the prevalence of berylliosis. American Journal of Industrial Medicine. 32:337- ...
Granulomatous disorders with high levels of calcitriol may be found in patients with sarcoidosis, berylliosis, tuberculosis, ...
Berylliosis, fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous ...
Berylliosis. Fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous ...
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Breathing it in is a great danger as it causes berylliosis, a form of pneumonia. The highest beryllium content I could find in ... Berylliosis - Wikipedia. Since the 1920s, beryllium has been used in electronics, ceramics, research and development labs, ...
Berylliosis - Preferred Concept UI. M0002404. Scope note. A form of pneumoconiosis caused by inhaled rare metal BERYLLIUM or ... Berylliosis is characterized by an acute inflammatory reaction in the upper airway leading to BRONCHIOLITIS; PULMONARY EDEMA; ... Berylliosis is characterized by an acute inflammatory reaction in the upper airway leading to BRONCHIOLITIS; PULMONARY EDEMA; ...
Berylliosis. *Brucellosis. *Byssinosis ("brown lung"). *Chalicosis. *Chronic solvent-induced encephalopathy. *Chimney sweeps ...
Lab Test Name (Berylliosis) {3} Value Set Details (link) Beryllium Fld-mCnc Beryllium Fld-sCnc Beryllium Tiss-sCnt LPT 1 umol ...
Berylliosis tends to mimic the appearance of sarcoidosis which in turn, at times, resembles silicosis. Coal workers ... Berylliosis tends to mimic the appearance of sarcoidosis which in turn, at times, resembles silicosis. Coal workers ... Berylliosis tends to mimic the appearance of sarcoidosis which in turn, at times, resembles silicosis. Coal workers ... Keywords: Imaging; Chest radiography; Chest CT; Asbestosis; Silicosis; Coal workers pneumoconiosis; Berylliosis; Talcosis; ...
This web site is intended to offer guidance to sourcing information about Sarcoidosis and Lyme Disease. This is the first site in Australia to offer any type of support for persons with Sarcoidosis. As a person who has had Sarcoidosis since 1985 I understand the frustrations that come with this disease. The web address is www.sarcoidosisaustralia.com and the blog at www.sarcoidosis-sarcoid.com. You can reach Sue personaly by emailing her at suppor[email protected] or phone her directly on 0488 603 532
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Siderosis (iron exposure e.g. welding/iron foundry workers); Berylliosis (beryllium exposure e.g. air fuel, dentistry); ...
RESULTS: Hypercalcemia was described in various granulomatous diseases including sarcoidosis, tuberculosis, berylliosis, ...
... monosomy 2q duplication 1p Chronic berylliosis Chronic bronchitis Chronic demyelinizing neuropathy with IgM monoclonal Chronic ...
Toxic vapors from berylliosis-sensitive beryllium can cause dermatitis in those sensitive to it, yet it tastes pleasant. One- ... Inhalation can cause berylliosis, a persistent and potentially fatal allergy illness, even though beryllium has a pleasant ...
Beryllium induced lung disease, also known as berylliosis, has been shown in dogs after being exposed to Beryllium Oxide, ...
... inhaled beryllium-containing dusts that can cause a chronic life-threatening allergic disease in some people called berylliosis ...
... berylliosis, fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous ...
... are also plans to conduct European proof-of-concept clinical development of RLF-100 in the treatment of chronic berylliosis, an ...
Berylliosis. Besnier-Boeck-Schaumann.... Bibliophobia. Bicuspid aortic valve. Biliary atresia. Binswangers disease. ...
Berylliosis. Caplans syndrome. Chalicosis. Coalworkers pneumoconiosis. Siderosis. Silicosis. Talcosis. Byssinosis. ...
  • Inhalation can cause berylliosis, a persistent and potentially fatal allergy illness, even though beryllium has a pleasant taste. (engineeringchoice.com)
  • The commercial use of beryllium requires the use of appropriate dust control equipment and industrial controls at all times because of the toxicity of inhaled beryllium-containing dusts that can cause a chronic life-threatening allergic disease in some people called berylliosis. (periodic-table.org)
  • Berylliosis, fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy, idiopathic eosinophilic pneumonias, symptomatic sarcoidosis. (nih.gov)
  • Berylliosis tends to mimic the appearance of sarcoidosis which in turn, at times, resembles silicosis. (sagepub.com)
  • Asbestosis and berylliosis also were diagnosed. (cdc.gov)
  • Sizar O, Talati R. Berylliosis (chronic beryllium disease). (medscape.com)
  • A high-resolution CT scan of the chest showing the typical ground glass appearance in a patient with chronic beryllium disease, or berylliosis. (medscape.com)
  • A histopathology slide (hematosin and eosin stain) showing the typical well-formed granuloma of chronic beryllium disease, or berylliosis. (medscape.com)
  • Beryllium disease (berylliosis). (nih.gov)
  • This program also supports research on non-infectious granulomatous diseases including sarcoidosis, berylliosis, and hypersensitivity pneumonitis. (nih.gov)
  • An overall population 36 berylliosis patients and 38 Be-sensitization without lung granulomas and 86 Be-exposed controls was analysed to assess the role of the individual HLA-class II polymorphisms associated with BH-susceptibility in HLA-DPGlu69 negative subjects by univariate and multivariate analysis. (nih.gov)