A form of pneumoconiosis caused by inhaled rare metal BERYLLIUM or its soluble salts which are used in a wide variety of industry including alloys, ceramics, radiographic equipment, and vacuum tubes. Berylliosis is characterized by an acute inflammatory reaction in the upper airway leading to BRONCHIOLITIS; PULMONARY EDEMA; and pneumonia.
Beryllium. An element with the atomic symbol Be, atomic number 4, and atomic weight 9.01218. Short exposure to this element can lead to a type of poisoning known as BERYLLIOSIS.
Uncontrolled release of a chemical from its containment that either threatens to, or does, cause exposure to a chemical hazard. Such an incident may occur accidentally or deliberately.
A group of the D-related HLA antigens (human) found to differ from the DR antigens in genetic locus and therefore inheritance. These antigens are polymorphic glycoproteins comprising alpha and beta chains and are found on lymphoid and other cells, often associated with certain diseases.
Transmembrane proteins that form the beta subunits of the HLA-DP antigens.
Acute respiratory illness in humans caused by the Muerto Canyon virus whose primary rodent reservoir is the deer mouse Peromyscus maniculatus. First identified in the southwestern United States, this syndrome is characterized most commonly by fever, myalgias, headache, cough, and rapid respiratory failure.
Granulomatous disorders affecting one or more sites in the respiratory tract.
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
Washing liquid obtained from irrigation of the lung, including the BRONCHI and the PULMONARY ALVEOLI. It is generally used to assess biochemical, inflammatory, or infection status of the lung.
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
Created 7 April 1992 as a result of the division of Yugoslavia.
A genus in the family FILOVIRIDAE consisting of several distinct species of Ebolavirus, each containing separate strains. These viruses cause outbreaks of a contagious, hemorrhagic disease (HEMORRHAGIC FEVER, EBOLA) in humans, usually with high mortality.
A highly fatal, acute hemorrhagic fever, clinically very similar to MARBURG VIRUS DISEASE, caused by EBOLAVIRUS, first occurring in the Sudan and adjacent northwestern (what was then) Zaire.
Diseases affecting the eye.
Pathological processes of the ENDOCRINE GLANDS, and diseases resulting from abnormal level of available HORMONES.
Disorders of the blood and blood forming tissues.
Disorders of connective tissue, especially the joints and related structures, characterized by inflammation, degeneration, or metabolic derangement.
Therapy of heavy metal poisoning using agents which sequester the metal from organs or tissues and bind it firmly within the ring structure of a new compound which can be eliminated from the body.
Severe irritant and vesicant of skin, eyes, and lungs. It may cause blindness and lethal lung edema and was formerly used as a war gas. The substance has been proposed as a cytostatic and for treatment of psoriasis. It has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP-85-002, 1985) (Merck, 11th ed).
Organic chemicals that form two or more coordination links with an iron ion. Once coordination has occurred, the complex formed is called a chelate. The iron-binding porphyrin group of hemoglobin is an example of a metal chelate found in biological systems.
Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
Global conflict involving countries of Europe, Africa, Asia, and North America that occurred between 1939 and 1945.
An excessive accumulation of iron in the body due to a greater than normal absorption of iron from the gastrointestinal tract or from parenteral injection. This may arise from idiopathic hemochromatosis, excessive iron intake, chronic alcoholism, certain types of refractory anemia, or transfusional hemosiderosis. (From Churchill's Illustrated Medical Dictionary, 1989)
The continuous sequence of changes undergone by living organisms during the post-embryonic developmental process, such as metamorphosis in insects and amphibians. This includes the developmental stages of apicomplexans such as the malarial parasite, PLASMODIUM FALCIPARUM.
The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.
A generic concept reflecting concern with the modification and enhancement of life attributes, e.g., physical, political, moral and social environment; the overall condition of a human life.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
The portion of an interactive computer program that issues messages to and receives commands from a user.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Sequential operating programs and data which instruct the functioning of a digital computer.
A form of pneumoconiosis resulting from inhalation of dust containing crystalline form of SILICON DIOXIDE, usually in the form of quartz. Amorphous silica is relatively nontoxic.
An interactive process whereby members of a community are concerned for the equality and rights of all.
The exposure to potentially harmful chemical, physical, or biological agents that occurs as a result of one's occupation.
A diffuse parenchymal lung disease caused by inhalation of dust and by tissue reaction to their presence. These inorganic, organic, particulate, or vaporized matters usually are inhaled by workers in their occupational environment, leading to the various forms (ASBESTOSIS; BYSSINOSIS; and others). Similar air pollution can also have deleterious effects on the general population.
A form of pneumoconiosis caused by inhalation of asbestos fibers which elicit potent inflammatory responses in the parenchyma of the lung. The disease is characterized by interstitial fibrosis of the lung, varying from scattered sites to extensive scarring of the alveolar interstitium.
The repetitive uterine contraction during childbirth which is associated with the progressive dilation of the uterine cervix (CERVIX UTERI). Successful labor results in the expulsion of the FETUS and PLACENTA. Obstetric labor can be spontaneous or induced (LABOR, INDUCED).

Differential susceptibilities to chronic beryllium disease contributed by different Glu69 HLA-DPB1 and -DPA1 alleles. (1/92)

Chronic beryllium disease (CBD) is associated with the allelic substitution of a Glu69 in the HLA-DPB1 gene. Although up to 97% of CBD patients may have the Glu69 marker, about 30-45% of beryllium-exposed, unaffected individuals carry the same marker. Because CBD occurs in only 1-6% of exposed workers, the presence of Glu69 does not appear to be the sole genetic factor underlying the disease development. Using two rounds of direct automated DNA sequencing to precisely assign HLA-DPB1 haplotypes, we have discovered highly significant Glu69-containing allele frequency differences between the CBD patients and a beryllium-exposed, nondiseased control group. Individuals with DPB1 Glu69 in both alleles were almost exclusively found in the CBD group (6/20) vs the control group (1/75). Whereas most Glu69 carriers from the control group had a DPB1 allele *0201 (68%), most Glu69 carriers from the CBD group had a non-*0201 DPB1 Glu69-carrying allele (84%). The DPB1 allele *0201 was almost exclusively (29/30) associated with DPA1 *01 alleles, while the non-*0201 Glu69-containing DPB1 alleles were closely associated with DPA1 *02 alleles (26/29). Relatively rare Glu69-containing alleles *1701, *0901, and *1001 had extremely high frequencies in the CBD group (50%), as compared with the control group (6.7%). Therefore, the most common Glu69-containing DPB1 allele, *0201, does not seem to be a major disease allele. The results suggest that it is not the mere presence of Glu69, per se, but specific Glu69-containing alleles and their copy number (homozygous or heterozygous) that confer the greatest susceptibility to CBD in exposed individuals.  (+info)

Partial IL-10 inhibition of the cell-mediated immune response in chronic beryllium disease. (2/92)

Chronic beryllium disease (CBD) provides a human disorder in which to study the delayed type IV hypersensitivity response to persistent Ag that leads to noncaseating pulmonary granuloma formation. We hypothesized that, in CBD, failure of IL-10 to modulate the beryllium-specific, cell-mediated immune response would result in persistent, maximal cytokine production and T lymphocyte proliferation, thus contributing to the development of granulomatous lung disease. To test this hypothesis, we used bronchoalveolar lavage cells from control and CBD subjects to evaluate the beryllium salt-specific production of endogenous IL-10 and the effects of exogenous human rIL-10 (rhIL-10) on HLA expression, on the production of IL-2, IFN-gamma, and TNF-alpha, and on T lymphocyte proliferation. Our data demonstrate that beryllium-stimulated bronchoalveolar lavage cells produce IL-10, and the neutralization of endogenous IL-10 does not increase significantly cytokine production, HLA expression, or T lymphocyte proliferation. Second, the addition of excess exogenous rhIL-10 partially inhibited the beryllium-stimulated production of IL-2, IFN-gamma, and TNF-alpha; however, we measured no change in T lymphocyte proliferation or in the percentage of alveolar macrophages expressing HLA-DP. Interestingly, beryllium salts interfered with an IL-10-stimulated decrease in the percentage of alveolar macrophages expressing HLA-DR. We conclude that, in the CBD-derived, beryllium-stimulated cell-mediated immune response, low levels of endogenous IL-10 have no appreciable effect; exogenous rhIL-10 has a limited effect on cytokine production and no effect on T lymphocyte proliferation or HLA expression.  (+info)

Chronic beryllium disease and cancer risk estimates with uncertainty for beryllium released to the air from the Rocky Flats Plant. (3/92)

Beryllium was released into the air from routine operations and three accidental fires at the Rocky Flats Plant (RFP) in Colorado from 1958 to 1989. We evaluated environmental monitoring data and developed estimates of airborne concentrations and their uncertainties and calculated lifetime cancer risks and risks of chronic beryllium disease to hypothetical receptors. This article discusses exposure-response relationships for lung cancer and chronic beryllium disease. We assigned a distribution to cancer slope factor values based on the relative risk estimates from an occupational epidemiologic study used by the U.S. Environmental Protection Agency (EPA) to determine the slope factors. We used the regional atmospheric transport code for Hanford emission tracking atmospheric transport model for exposure calculations because it is particularly well suited for long-term annual-average dispersion estimates and it incorporates spatially varying meteorologic and environmental parameters. We accounted for model prediction uncertainty by using several multiplicative stochastic correction factors that accounted for uncertainty in the dispersion estimate, the meteorology, deposition, and plume depletion. We used Monte Carlo techniques to propagate model prediction uncertainty through to the final risk calculations. We developed nine exposure scenarios of hypothetical but typical residents of the RFP area to consider the lifestyle, time spent outdoors, location, age, and sex of people who may have been exposed. We determined geometric mean incremental lifetime cancer incidence risk estimates for beryllium inhalation for each scenario. The risk estimates were < 10(-6). Predicted air concentrations were well below the current reference concentration derived by the EPA for beryllium sensitization.  (+info)

Association of man-made mineral fibre exposure and sarcoidlike granulomas. (4/92)

It is assumed that sarcoidosis is caused by inhalation of air borne agents in susceptible persons triggering the inflammatory reaction. The association of metallic dust exposure, such as beryllium and aluminium, and sarcoidlike pulmonary disorders is well known. The ability of man-made mineral fibres (MMMF) to cause granulomatous lung disease has not been appreciated until now. Recently, we observed the association of sarcoidlike granulomatous reaction and occupational history of glass fibre exposure. We hypothesized that there might be a relationship between MMMF exposure and the development of sarcoidlike granulomas. Therefore, the records of 50 sarcoidosis patients-who visited our outpatient clinic between 1996 and 1999 were reviewed. This revealed that 14 cases recalled a history of exposure to either glass fibres or rock wool, both MMMF fibres. The available obtained tissue specimens (n = 12) were reviewed. In six cases electron microscopy qualitative analysis of small fragments of the tissue revealed among others silica, aluminium and sometimes titanium. A distinct relation between fibre deposits fibre deposits and granulomas was found. These findings indicate that in susceptible people MMMF exposure might be related to a chronic granulomatous disease similar to chronic beryllium disease.  (+info)

Government laboratory worker with lung cancer: comparing risks from beryllium, asbestos, and tobacco smoke. (5/92)

Occupational medicine physicians are frequently asked to establish cancer causation in patients with both workplace and non-workplace exposures. This is especially difficult in cases involving beryllium for which the data on human carcinogenicity are limited and controversial. In this report we present the case of a 73-year-old former technician at a government research facility who was recently diagnosed with lung cancer. The patient is a former smoker who has worked with both beryllium and asbestos. He was referred to the University of California, San Francisco, Occupational and Environmental Medicine Clinic at San Francisco General Hospital for an evaluation of whether past workplace exposures may have contributed to his current disease. The goal of this paper is to provide an example of the use of data-based risk estimates to determine causation in patients with multiple exposures. To do this, we review the current knowledge of lung cancer risks in former smokers and asbestos workers, and evaluate the controversies surrounding the epidemiologic data linking beryllium and cancer. Based on this information, we estimated that the patient's risk of lung cancer from asbestos was less than his risk from tobacco smoke, whereas his risk from beryllium was approximately equal to his risk from smoking. Based on these estimates, the patient's workplace was considered a probable contributing factor to his development of lung cancer.  (+info)

Beryllium presentation to CD4+ T cells underlies disease-susceptibility HLA-DP alleles in chronic beryllium disease. (6/92)

Chronic beryllium disease results from beryllium exposure in the workplace and is characterized by CD4(+) T cell-mediated inflammation in the lung. Susceptibility to this disease is associated with particular HLA-DP alleles. We isolated beryllium-specific T cell lines from the lungs of affected patients. These CD4(+) T cell lines specifically responded to beryllium in culture in the presence of antigen-presenting cells that expressed class II MHC molecules HLA-DR, -DQ, and -DP. The response to beryllium was nearly completely and selectively blocked by mAb to HLA-DP. Additional studies showed that only certain HLA-DP alleles allowed presentation of beryllium. Overall, the DP alleles that presented beryllium to disease-specific T cell lines match those implicated in disease susceptibility, providing a mechanism for this association. Based on amino acid residues shared by these restricting and susceptibility DP alleles, our results provide insight into the residues of the DP beta-chain required for beryllium presentation.  (+info)

HLA-DP allele-specific T cell responses to beryllium account for DP-associated susceptibility to chronic beryllium disease. (7/92)

Occupational exposure to small molecules, such as metals, is frequently associated with hypersensitivity reactions. Chronic beryllium (Be) disease (CBD) is a multisystem granulomatous disease that primarily affects the lung, and occurs in approximately 3% of individuals exposed to this element. Immunogenetic studies have demonstrated a strong association between CBD and possession of alleles of HLA-DP containing glutamic acid (Glu) at position 69 in the HLA-DP beta-chain. T cell clones were raised from three patients with CBD in whom exposure occurred 10 and 30 years previously. Of 25 Be-specific clones that were obtained, all were restricted by HLA-DP alleles with Glu at DP beta69. Furthermore, the proliferative responses of the clones were absolutely dependent upon DP beta Glu(69) in that a single amino acid substitution at this position abolished the response. As befits a disease whose pathogenesis involves a delayed type hypersensitivity response, the large majority of Be-specific clones secreted IFN-gamma (Th1) and little or no IL-4 (Th2) cytokines. This study provides insights into the molecular basis of DP2-associated susceptibility to CBD.  (+info)

IL-4 fails to regulate in vitro beryllium-induced cytokines in berylliosis. (8/92)

Bronchoalveolar lavage (BAL) cells from patients with chronic beryllium disease (CBD) have been used to evaluate the beryllium-specific immune response and potential immunotherapeutics. Beryllium induces interferon-gamma (IFN-gamma), interleukin-2 (IL-2), tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-10 (IL-10) from BAL cells. An antibody to IL-2 and recombinant human (rHu) IL-10 is able to partially suppress the beryllium-stimulated immune response. To obtain BAL cells, bronchoscopy is required, providing risk to the patient and a limited number of cells to study the immune response. As a result, the objectives of the study were to determine 1) whether CBD peripheral blood mononuclear cells (PBMNs) stimulated with beryllium would produce a similar cytokine pattern as BAL cells, and 2) whether this response could be modulated by interleukin-4 (IL-4), an immunomodulatory cytokine. CBD and normal individuals' PBMN and BAL cells were stimulated with and without beryllium sulfate. To modulate this antigen-stimulated response, we added rHu IL-4 to the unstimulated and beryllium-stimulated cells. IFN-gamma, IL-2, TNF-alpha, IL-6 and IL-10 cytokine concentrations were determined from cell supernatants by enzyme-linked immunosorbent assays (ELISA), while IL-4 messenger ribonucleic acid (mRNA) was assessed using polymerase chain reaction (PCR). Beryllium did not stimulate any of these cytokines from normal PBMNs. Increasing levels of IL-6 and TNF-alpha were produced constituitively by CBD PBMNs over time. Compared to the unstimulated CBD PBMNs, beryllium stimulated significant IFN-gamma, TNF-alpha, IL-2, IL-6 and IL-10 production. This response was similar to that stimulated from CBD BAL cells, although of a much lower magnitude. Low levels of IL-4 mRNA were found in CBD and control PBMNs, which were not increased with beryllium stimulation. The beryllium-stimulated cytokine levels were not decreased by the addition of IL-4. IL-4 was unable to downregulate any of these beryllium-stimulated cytokines from CBD BAL cells or increase IL-4 mRNA from either CBD PBMN or BAL cells, and thus is an unlikely immunomodulatory agent in CBD. From the data, it was concluded that chronic beryllium disease peripheral blood mononuclear cells provide a model to study the beryllium-stimulated immune response. Interleukin-4's inability to downregulate any of the beryllium-stimulated cytokines makes it an unlikely therapeutic candidate in chronic beryllium disease.  (+info)

Unfortunately no cure has been found yet; but treatment and management of chronic beryllium disease can slow down the progression of this disease.
The human leukocyte antigen (HLA) complex is a series of genes located on chromosome 6 that are important in normal immune function. Susceptibility to chronic beryllium disease, a granulomatous lung disease that appears in workers exposed to beryllium, is modified by genetic variants of the HLA-DP subregion. Evaluation of HLA-DPB1 sequence motifs in current and former beryllium workers implicated
Information on the respiratory infections beryllium sensitization and chronic beryllium disease (CBD) and their symptoms, causes, diagnosis, and treatment.
Click to launch & play an online audio visual presentation by Prof. Lee Newman on Genetic susceptibility in granulomatous disorders: chronic beryllium disease and sarcoidosis, part of a collection of multimedia lectures.
Chronic beryllium disease (CBD) can be caused when one is exposed to fumes, dust, powder containing beryllium and has an allergic reaction. Most people ...
Inhalation of beryllium (Be) has been associated with 2 pulmonary syndromes, which are an acute chemical pneumonitis and a granulomatous lung disease known as chronic beryllium disease (CBD), or berylliosis. In acute beryllium disease, the metal acts as a direct chemical irritant, causing a nonspecific inflammatory reaction (acute chemical p...
Inhalation of beryllium (Be) has been associated with 2 pulmonary syndromes, which are an acute chemical pneumonitis and a granulomatous lung disease known as chronic beryllium disease (CBD), or berylliosis. In acute beryllium disease, the metal acts as a direct chemical irritant, causing a nonspecific inflammatory reaction (acute chemical p...
Bronchoalveolar lavage (BAL) cells from patients with chronic beryllium disease (CBD) have been used to evaluate the beryllium-specific immune response and potential immunotherapeutics. Beryllium induces interferon-y (IFN-y), interleukin-2 (IL-2), tumour necrosis factor-a (TNF-a), interleukin-6 (IL-6) and interleukin-10 (IL-10) from BAL cells. An antibody to IL-2 and recombinant human (rHu) IL-10
Sigma-Aldrich offers abstracts and full-text articles by [Gina M Clayton, Yang Wang, Frances Crawford, Andrey Novikov, Brian T Wimberly, Jeffrey S Kieft, Michael T Falta, Natalie A Bowerman, Philippa Marrack, Andrew P Fontenot, Shaodong Dai, John W Kappler].
Learn more about Berylliosis at Reston Hospital Center DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
Learn more about Berylliosis at Reston Hospital Center DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
A water soluble corticosteroid used to treat severe allergic reactions, dermatologic diseases, endocrine disorders, gastrointestinal diseases, hematological disorders, neoplastic diseases, nervous system conditions, ophthalmic diseases, renal diseases, respiratory diseases, and rheumatic disorders ...
To study the immunologic function of bursin, we analyzed the effects of anti-bursin monoclonal antibody (mAb) on the immunosuppression in ducks (Cherry Valley duck) by injecting various doses of the anti-bursin mAb into 13-d duck embryos. After hatch, cell-mediated immune activity and humoral responses were studied using lymphocyte proliferation test, tube agglutination test, and indirect enzyme-linked immuno-sorbent assay to detect anti-Escherichia coli antibodies and antibodies to Riemerella anatipester, respectively. Simultaneously, relative weights (BW-adjusted) of bursa of Fabricius (BF), spleen, and thymus were determined. Additionally, the morphology of BF, spleen, and thymus was examined at various ages using conventional histology. Follicle morphology of BF was analyzed by image analysis. The results indicated that anti-bursin mAb markedly decreased duck lymphocyte proliferation, the antibody-producing ability to bacteria, as well as the relative BF weight. Moreover, the anti-bursin mAb ...
Some new tests have been introduced, unfortunately there are no published studies demonstating their validity. One test is called an immune tolerance test. It measures T cell proliferation after exposure to select Lyme antigens. There exist very few studies regarding such lymphocyte proliferation tests for diagnosing Lyme. Oddly, the background paper published by the manufacturer, describing the underpinnings of this technology, cites an old Wormser study in the foot notes. The Wormser study using somewhat different methods concluded the test was insensitive but specific ...
One of the first identified age-associated functional changes in immune response was decreased DTH responses. In fact the DTH response is an example of a T.h response mediated primarily through th-1-type cytokines although many events are required before proliferation, assessment of lymphocyte proliferation often has been used as an indicator of ...
Includes alphabet are there any alternatives to plenty fish books, counting books, and books teaching concepts. If the internet settings are not set to medium level than the cookies will be blocked. The rinsing stage contaminates where to meet international singles in the usa the cleaning fluid with residual liquid and the cleaning fluid becomes more contaminated each time the cloth or sponge is rinsed. The commercial use of beryllium requires the use of appropriate dust control equipment and industrial controls at all times because of the toxicity of inhaled beryllium-containing dusts that can cause a chronic life-threatening allergic disease in some people called berylliosis. Exquisitely prepared breakfast, with vegan and gluten free options. Where to meet black singles in canada free to further validate these results, we treated the cells with laser microirradiation. Thomas married sarah browne born clarke in, at age 24 at marriage place. Split shot rig this is about as basic as you can get ...
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Beryllium can be harmful if it is inhaled, depending on how much beryllium one inhales and how long the exposure lasts. If beryllium air levels are high enough (greater than 1000 µg/m3), an acute condition can result. This condition resembles pneumonia and is called acute beryllium disease.[6]. Individuals who are sensitive to beryllium can develop an inflammatory reaction in the respiratory system. This is called chronic beryllium disease (CBD), and can occur many years after exposure to higher than normal levels of beryllium (greater than 0.5 µg/m3). This disease can make you feel weak and tired, and can cause difficulty in breathing. It can also result in anorexia, weight loss, and may also lead to right side heart enlargement and heart disease in advanced cases. Some people who are sensitized to beryllium may not have any symptoms. The general population is unlikely to develop acute or chronic beryllium disease because ambient air levels of beryllium are normally very low ...
Chronic beryllium disease (CBD) appeared to be waning 30 yrs ago 1. In 1980, less than one case per year was reported and the incidence rate per ton of beryllium produced had declined from between five and 10, to less than 0.001. CBD appeared to be heading toward the medical archives as a success story of environmental control in the absence of understanding of the pathogenesis of the disease. However, in 1982, an immunological test performed on lymphocytes recovered from the bronchoalveolar lavage fluid demonstrated a marked increased in the number of beryllium-sensitive cells in the lung compared to the blood, strongly suggesting that CBD was a hypersensitivity to beryllium 2. The findings of that initial study were confirmed in larger studies 3 and by different investigators 4, 5. Around 10 yrs later, an immunological test (the beryllium lymphocyte proliferation test (BeLPT)) was initially used in cross-sectional studies and later in the surveillance and screening of current and former ...
DOE describes Hanford as the worlds largest environmental remediation project. In addition to the remnants of nine plutonium reactors, Hanford holds 4.6 million pounds of irradiated uranium fuel rods and 53 million gallons of radioactive waste buried in underground tanks, some of which have leaked into the groundwater and are moving toward the Columbia River. Radiation has long been the dean of hazards at nuclear cleanup sites, but in April 2009, the Hanford Advisory Board, a group chartered by DOE that includes current and former Hanford workers, medical specialists, environmental and worker-safety advocates, and local government officials, wrote a letter advising the department that from a worker safety perspective ... beryllium currently rates as a greater hazard than radiation. The letter included a disquieting calculation: Studies have found that between 2 percent and 6 percent of people exposed to beryllium will become sensitized or develop CBD. At the time of the letter, 115 of 4,583 ...
Chronic Beryllium Disease (CBD) primarily affects the lungs. CBD may occur among dental laboratory technicians when they inhale dust containing beryllium when working on items such as dental crowns, bridges, and partial denture frameworks made from dental alloys containing beryllium. CBD may develop within months after initial exposure to beryllium or may have a very slow onset and not develop until years after exposure to beryllium has occurred. The amount or length of exposure to beryllium necessary to cause a specific individual to develop CBD is not known, but recent information suggests that even short exposures (weeks or months) to levels of beryllium below OSHAs PEL of 2 μg/m3 averaged over an 8-hour day may lead to CBD in some workers (Source: OSHA). ...
People working or living near beryllium industries have the greatest potential for exposure to beryllium. Lung damage has been observed in people exposed to high levels of beryllium in the air. About 1-15% of all people occupationally-exposed to beryllium in air become sensitive to beryllium and may develop chronic beryllium disease (CBD), an irreversible and sometimes fatal scarring of the lungs. CBD may be completely asymptomatic or begin with coughing, chest pain, shortness of breath, weakness, and/or fatigue. Beryllium has been found in at least 535 of the 1,613 National Priorities List sites identified by the Environmental Protection Agency (EPA).
Beryllium is a crucial metal in the automotive, aviation, nuclear and consumer industries. The unique combination of high rigidity, low density, thermal stability and conductivity makes it highly useful in consumer products such as cell phones and computers. However, beryllium is considered to be the most toxic non-radioactive element, a class A carcinogen, and the cause oflife-threatening chronic beryllium disease. Even with its poor reputation, its use is continued in commercial, industrial, and governmental applications. In contrast, the efforts to understand berylliums fundamental chemistry have been severely neglected. We are interested in developing a suite of chemical chelators which show strong and selective binding towards beryllium. These studies will lead to specific applications such as the detection of beryllium in the environment, protocols to remediate its contamination, and therapies for individuals exposed to its toxicity. This work will focus on both the computational studies ...
Summary of lung function and beryllium exposure of case 2. (A) Results of pulmonary function tests before, during, and after acute work-related illness. (B) TWA
Schubauer-Berigan MK, Deddens JA, Couch JR, Petersen MR. Risk of lung cancer associated with quantitative beryllium exposure metrics within an occupational cohort. Occup Environ Med. 2011; 68(5): 354-60 ...
The Occupational Safety and Health Administration (OSHA) recently issued a final rule modifying a 40-year-old standard pertaining to exposure to beryllium and beryllium compounds. It contains new requirements for general, construction and shipyard industries. Similar to the recent changes to crystalline silica regulations, the rule is anticipated to save lives and protect workers from serious illnesses. Beryllium and beryllium compounds are lightweight, extremely strong metals used in the aerospace, electrical, energy, telecommunications, medical and defense fields. Beryllium-copper alloys are frequently used for their electrical and thermal conductivity as well as their hardness. Beryllium oxide is used as a component in ceramics for electronics and other electrical equipment because of its heat conductivity, high strength, hardness and electrical insulating properties. Unfortunately, beryllium is highly toxic when inhaled. Inhaling airborne beryllium can result in a lung condition known as ...
Silver, K., Kukulka, G., Gorniewicz, J., and Rayman, K., Genetic susceptibility testing for beryllium: Worker Knowledge, beliefs and attitudes, Amer. J. of Industrial Med., 54(7): 521-32 (July 2011) Dobbin, D., Turpin, R.D., Silver, K. et al, Hazardous Waste. Chapter 10. In: Occupational Health: Recognizing and Preventing Work-Related Disease and Injury, 5 th edition. Levy, B.S., Wegman, D.H., Baron, S., and Sokas, R. Eds. (New York: Oxford University Press, 2011), pp. Silver, K. and Clapp, R., Environmental surveillance at Los Alamos: an independent reassessment of historical data, Risk Analysis, 26(4): 893-906 (August 2006) Silver, K. and Sharp, R., Ethical considerations in testing workers for the -Glu69 marker of genetic susceptibility to chronic beryllium disease, 48(4): 434-443 (April 2006) Silver, K., The Energy Employees Occupational Illness Compensation Program Act. AAOHN Journal, 53(6): 267-77 (June 2005) SELECTED PRESENTATIONS Green, C.C. and Silver, K., Analysis of the Energy Claims ...
NOTICE OF FINAL DECISION This is the decision of the Final Adjudication Branch (FAB) concerning the above-noted claim for benefits under the Energy Employees Occupational Illness Compensation Program Act of 2000, as amended (EEOICPA), 42 U.S.C. 7384 et seq. For the reasons stated below, this claim for survivor benefits under Part B of EEOICPA based on chronic beryllium disease (CBD) is denied.. STATEMENT OF THE CASE. On September 13, 2010, the claimant filed a Form EE-2 claiming survivor benefits as the alleged surviving spouse of [Employee], and alleged that the employee had contracted bladder cancer, colon cancer, chronic obstructive pulmonary disease (COPD), chronic renal failure, coronary artery disease, and CBD due to his work. On July 1, 2011, FAB issued a final decision accepting this claim under Part E of EEOICPA as the surviving spouse of [Employee]. In that decision, FAB found that [Employee] was a covered Department of Energy (DOE) contractor employee at the Portsmouth Gaseous ...
Beryllium nitrate, also known as beryllium dinitrate, is an ionic beryllium salt of nitric acid with the chemical formula Be(NO3)2. Each formula unit is composed of one Be2+ cation and two NO3− anions. Beryllium nitrate is a toxic chemical, like all other beryllium compounds. It is also an irritant in small doses. When burned, it gives off irritating or toxic fumes. However, when massive short-term exposure occurs, acute pneumonitis can set in, but symptoms do not manifest themselves for 3 days. Beryllium nitrate can be prepared by reacting beryllium hydroxide in nitric acid. s NIOSH Pocket Guide to Chemical Hazards #0054. National Institute for Occupational Safety and Health (NIOSH). Beryllium Nitrate (ICSC). IPCS INCHEM. Retrieved 13 September 2010. Walsh, Kenneth (2009). Beryllium chemistry and processing. ASM International. pp. 121-122. ISBN 978-0-87170-721-5. Retrieved 3 January 2011 ...
Exposure to beryllium can occur when cutting, torching, or welding of the materials listed above. Employees who torch or weld these materials run the greatest risk of exposure. Workers are primarily exposed to beryllium by breathing in dusts, fumes, or mists containing beryllium. Beryllium compounds can also get on the skin, contaminate clothing or food, and be ingested.. Employers must assess employee exposures to beryllium. That includes determining if material being received at the recycling facility contains beryllium. If it does then the employer must determine if dust, fumes, or mists are being created in the processing of the beryllium scrap. This can be done by monitoring employees and areas for in a manner similar to monitoring for other hazardous metals such as lead or cadmium.. Employers must establish and maintain a regulated area if employees are, or can reasonably be expected to be, exposed to airborne beryllium at levels above the listed TWA PEL or STEL in that work area. ...
Los Alamos National Laboratory announced Wednesday it is notifying nearly 2,000 current and former employees and visitors that they may have been exposed to beryllium in the lab and may be at risk of disease.
Read chapter 5 Assessment of Other Health End Points: Beryllium is an important metal that is used in a number of industries-including the defense, aer...
Read chapter Front Matter: Beryllium is an important metal that is used in a number of industries-including the defense, aerospace, automotive, medical...
Beryllium (chemical symbol Be) is an alkaline earth metallic element, that has no known function in any organism. Unfortunately beryllium is very poisonous, manifesting as chronic beryllium lung disease, which causes premature mortality in one th...
Synopsis of Global Beryllium Copper Market 2017 Research Report. The report about Global Beryllium Copper Market 2017 constitutes of pervasive fundamental research along with a structured analysis of qualitative as well as quantitative facet by assorted industry connoisseurs and main opinion leaders to gain a profound insight of the market and industry performance.. The report Global Beryllium Copper Market 2017 gives a clear sight of the present-day market scenario which comprises of historical and estimated forthcoming market size on the basis of technological growth, value and volume, prominent economic and governing elements in the market.. Do Inquiry Before Accessing Global Beryllium Copper Market 2017 Report at: https://market.biz/report/global-beryllium-copper-market-icrw/83388/#inquiry. The report Global Beryllium Copper Market 2017 further imparts detail information about approaches and tactics used by elite key players in the Beryllium Copper industry. It also gives an extensive ...
To investigate the effects of short-term exposure of beryllium on the human immune system, the proportion of T-lymphocytes such as CD3+, CD4+, CD8+, CD95, and NK cells, andthe proportion of B cells and TNFα level in peripheral blood and immunoglobulins in the serum of 43 exposed workers and 34 healthy control subjects were studied. External exposure to beryllium was measured by atomic absorption spectrometer as recommended by the NIOSH analytical method 7300. T lymphocyte subpopulation analysis was carried out with flow cytometer. The working duration of exposed workers was less than 3 months and the mean ambient beryllium level was 3.4 μg/m(3), 112.3 μg/m(3), and 2.3 μg/m(3) in molding (furnace), deforming (grinding), and sorting processes, respectively (cited from Kim et al., 2008). However, ambient beryllium level after process change was non-detectable (| 0.1 μg/m(3)). The number of T lymphocytes and the amount of immunoglobulins in the beryllium-exposed workers and control subjects were not
PITTSBURGH, June 23, 2017 - The United Steelworkers (USW) today blasted the Administrations proposal to cancel important protections for shipyard and construction workers exposed to beryllium. Under the proposal OSHA released this morning, employers would no longer have to measure beryllium levels in the workplace or provide medical testing to workers at risk of fatal lung disease. In addition, workers would not have the right to wear protective clothing or to shower at the end of the work shift, making it possible for beryllium to be taken home and exposed to spouses and children. Beryllium is a highly useful metal, but it can cause a crippling and sometimes fatal disease that ultimately robs sufferers of the ability to breathe. OSHA issued new beryllium standards in January covering workers in all industries. Todays proposal eliminates most of the provisions covering the maritime and construction industries. The USW has members in both industries, including workers at the Newport News ...
Federal Register Volume 84, Number 189 (Monday, September 30, 2019)] [Rules and Regulations] [Pages 51377-51400] From the Federal Register Online via the Government Publishing Office [www.gpo.gov] [FR Doc No: 2019-21037] ======================================================================= ----------------------------------------------------------------------- DEPARTMENT OF LABOR Occupational Safety and Health Administration 29 CFR Parts 1915 and 1926 [Docket No. OSHA-H005C-2006-0870] RIN 1218-AD21 Occupational Exposure to Beryllium and Beryllium Compounds in Construction and Shipyard Sectors AGENCY: Occupational Safety and Health Administration (OSHA), Labor. ACTION: Final rule. ----------------------------------------------------------------------- SUMMARY: OSHA is finalizing the proposed rule on occupational exposure to beryllium and beryllium compounds in construction and shipyards by delaying the compliance deadlines for nearly all provisions of the standards to September 30, 2020. The ...
The first problem was one I was handed sort of on a silver platter when I went to the Mass General Hospital in Boston. I was in the department of medicine at Harvard was located at Mass General Hospital in the Huntington laboratories. The Chief of the laboratory, Dr. Joseph Aub who is a world known physician told me about beryllium and the fact that beryllium was causing very severe illness in women who were working in factories to remove the phosphors from inside fluorescent lamp bulbs. They wanted to retrieve the phosphors. One of the key ingredients in the phosphor was beryllium, the metal beryllium. Its the lightest metal with an atomic weight of 9.I think thats right. Its long time ago.. It caused some interesting effects that the scientists have studied, mainly if injected into rabbits it caused bad bone tumors. If it was injected into-well, these women who were scrubbing out the tubes died, almost all of them of severe pulmonary disease as a result of breathing in the beryllium. So he ...
On May 12, 2018, OSHA will begin to enforce a new rule on beryllium exposure in all forms, compounds, and mixtures in general, construction, and shipyard industries, prompting employers to take further responsibility to protect worker health from beryllium-related diseases.
Press Release issued Jul 21, 2017: The purpose of Global Beryllium Oxide (BeO) Powder Market report is to provide the newest industry data and Beryllium Oxide (BeO) Powder industry future trends, allowing consumers to identify the Beryllium Oxide (BeO) Powder market Application, Type, Manufacturers and Regions, Beryllium Oxide (BeO) Powder market Forecast up to 2022.
Ending decades of denial and inaction, the federal government has issued a tough new exposure standard for people who work with the toxic metal beryllium.
The question of whether the federal government has been at fault for the deaths and injuries of American beryllium workers will be the subject of a formal investigation by the General Accounting Office, the investigative arm of Congress.. The order to GAO to study the hazards of beryllium, a metal used by the Department of Defense and the Department of Energy because of its light weight and strength in the manufacture of weapons, came from a bipartisan group of eight members of Congress.. Led by Sen. Mike DeWine (R., O.), the ad hoc coalition includes Sens. John McCain (R., Ariz.) and Robert Bennett (R., Utah); and Reps. Marcy Kaptur (D., Toledo), Chris Shays (R., Conn.), Jim Kolbe (R., Ariz.), Tim Holden (D., Pa.), and Paul Kanjorski (D., Pa.).. Mr. DeWine began the call for a GAO investigation in April and has since been organizing and collecting support from colleagues. He said his actions were sparked by a series in The Blade that detailed a decades-long pattern of the U.S. government ...
On January 9, 2017, OSHA published a final rule amending its standards for occupational exposure to beryllium and beryllium compounds. United States Employment and HR Arnold & Porter 26 Jan 2017
Methods Quantitative area- and breathing-zone-based exposure measurements of airborne beryllium were made between 1953 and 2006 and used by plant personnel to estimate daily weighted average (DWA) exposure concentrations for sampled departments and operations. These DWA measurements were used to create a JEM with 18 exposure metrics, which was linked to the plant cohort consisting of 18 568 unique job, department and year combinations. The exposure metrics ranged from quantitative metrics (annual arithmetic/geometric average DWA exposures, maximum DWA and peak exposures) to descriptive qualitative metrics (chemical beryllium species and physical form) to qualitative assignment of exposure to other risk factors (yes/no). Twelve collapsed job titles with long-term consistent industrial hygiene samples were evaluated using regression analysis for time trends in DWA estimates. ...
With an atomic number of 4, beryllium has four electrons: two electron shells surround the atoms nucleus and two electrons in each shell. Beryllium is a rigid metal with an atomic mass of 9.0122. It...
The extraction of beryllium has been carried out in the presence of butyric acid. Of the solvents tried, viz., ether, benzene, chloroform, amyl acetate, ethyl acetate and carbon tetrachloride, chloroform is found to be the best, ethyl acetate being the next. 30.7 mg of BeO in solution as chloride is raised to a pH of 9.3 to 9.5 to which 10-15 ml of butyric acid is added. Four extractions with chloroform extract 99% of beryllium. ...
Find Beryllium Copper related suppliers, manufacturers, products and specifications on GlobalSpec - a trusted source of Beryllium Copper information.
The company plans to utilize this facility to manufacture small quantities of the listed controlled substances in bulk and to conduct analytical testing in support of the companys primary manufacturing facility in West Deptford, New Jersey. The controlled substances manufactured in bulk at this facility will be distributed to the companys customers.. No comments or objections have been received. DEA has considered the factors in 21 U.S.C. 823(a) and determined that the registration of Johnson Matthey Pharmaceutical Materials, Inc. to manufacture the listed basic classes of controlled substances is consistent with the public interest at this time. DEA has investigated Johnson Matthey Pharmaceutical Materials, Inc. to ensure that the companys registration is consistent with the public interest. The investigation has included inspection and testing of the companys physical security systems, verification of the companys compliance with state and local laws, and a review of the companys ...
The early rapid proliferation of epithelium is a pre-requisite for the rapid healing of wound surface of epithelium. In the present tests, the epithelial cells used for identifying test materials are taken from normal human skin, and the cells are cultured and grow in media containing the silicon and calcium microparticles of the present invention prepared according to the process of the Example 2. The specific combinations of chemical ingredients are pre-added in to the cell culture media used in the present tests at the concentrations as depicted in the Table of Fig. 3. One group serves as a control. Experimental groups with the test materials are compared to said control group to determine the induction effect of the test materials on the growth of cells. During the culture procedure, the media are replaced with fresh media having the same specific compositions every four days. Cell proliferation tests are conducted on the 12th and 20th day by counting the total number of cells grown in media ...
Products by element - Beryllium, include metal, alloy, compounds and fabrication products like sputtering targets etc. from ALB Materials Inc. - Page Total 1 Page 5 Records
QUEBEC CITY, QUEBEC--(Marketwire - March 31, 2010) - Nemaska Exploration Inc. («Nemaska» or «the Corporation») (TSX VENTURE:NMX) is pleased to announce that the most recent results from its current drill program on its lithium/beryllium (Whabouchi project, 100 % owned) continues to prove the high-grade, impressive width and continuity of the mineralized zone. Nemaska has received an additional 1,057 results from 15 holes. The latest results include 52.3 m at 1.85% Li2O, 165 ppm Be and 1579 ppm Rb and 22.8 m at 1.91 % Li2O, 130 ppm Be and 1503 ppm Rb.. «I am very pleased with the grade and width of our drill results to date which favourably compare to any other spodumene bearing pegmatite project currently in development around the world», commented Mr. Guy Bourassa, President and CEO. «The current drilling should be completed by mid-April, allowing us to finalize the resource calculation presently underway. I am also pleased to see that the Be and Rb grades remain constant throughout the ...
The report on Beryllium Oxide (BeO) Powder Market offers a complete analysis of the market. This was achieved with the help of the chronological data that was collected, the exhaustive qualitative insights, and the statistical data of the market. Thorough studies and researches were conducted and reliable methodologies were used to verify the data that was collected. Industrial experts were consulted and their opinions were taken into consideration while making studies of the market.. Primary researches were made which include surveys, opinions of seasoned analysts, and interviews. For collecting and verifying the data, the use of secondary researches was also made which includes reputable paid sources, industry body databases, entails, and trade journals. Both qualitative and quantitative assessments were made across different industrial aspects and market verticals.. Analysis of different trends that is prevailing in the market was made. The segmentation of the market was included. Studies of ...
Android OS version: 10.0_r4 For devices: Xiaomi Poco F1 (Beryllium) Authors build: Shahan_mik3 Source code: https://github.com/nitrogen-project...
Berylliums role in the SSGCID will include gene construction and expression testing in bacterial and cell-free systems, large-scale protein production and purification; crystallization screening and production, pre-screening of crystals before they are sent for data collection at the synchrotron beam-lines, and structure determination using the resulting data.
Beryllium 2007 Mustang Saleen S281 Extreme coupe, front right view. This photo is available in two wallpaper sizes; 800-600 wallpaper and 1024-768 wallpaper.
To see a rotating video of (almost) any of the samples of Beryllium from The Elements, click it below. Links will open in a new window ...
The heat treatment of corundum involving lattice diffusion of beryllium (Be) at temperatures over 1800°C has become a major issue in the gem trade.
Jorgen Kokke, executive vice president, global specialties and president of North America, and Jim Zallie, Ingredions president and CEO, officially unveiled the companys latest state-of-the-art plant-based protein manufacturing facility in South Sioux City, Neb., with members from the companys senior management team as well as its board of directors. The newly opened facility will produce high-quality protein isolates primarily for the nutrition, health and wellness categories.
We offer single or multiple-batch synthesis for IND-enabling toxicology studies and early phase clinical studies at our cGMP manufacturing facility. View!
Article Wire manufacturing facility - Case Study. Bench-Scale Stormwater Treatment StudyA large wire manufacturer in Washington State asked Dungeness Environmental to perform a treatability study on their stormwater run-off. The run-off requires reme...
This is the outline for this chapter. Please contribute to it by providing the overview and introduction to this group of diseases.. ...
Many conditions can cause Schaumann bodies, including: Sarcoidosis, Hypersensitivity pneumonitis, and Berylliosis. uncommonly, ...
Single or chronic exposure can lead to berylliosis, an incurable lung condition. In addition, beryllia is listed as a confirmed ...
Chronic berylliosis is a pulmonary and systemic granulomatous disease caused by exposure to beryllium. Between 1% - 15% of ... called chronic beryllium disease or berylliosis. The body's immune system recognises the beryllium as foreign particles and ...
The LTT for beryllium is now accepted as the gold standard for diagnosing berylliosis. MELISA differs from standard LTTs in ...
Berylliosis is associated with exposure to beryllium in the beryllium mining, aerospace and manufacturing industries. Chronic ...
... may be used to distinguish sarcoidosis from conditions with otherwise indistinguishable symptoms such as berylliosis ...
... and is distinct from berylliosis (also called chronic beryllium disease). After occupational safety procedures were put into ... place following the realization that the metal caused berylliosis around 1950, acute beryllium poisoning became extremely rare ...
He died at age 39 in Palo Alto, California of berylliosis and fibrosis of the lungs, caused by inhaling the beryllium used in ...
... berylliosis Calcitriol increases blood calcium levels ([Ca2+ ]) by: Promoting absorption of dietary calcium from the ...
Conglomerate masses may also occur in other pneumoconioses, such as talcosis, berylliosis (CBD), kaolin pneumoconiosis, and ...
Pneumoconiosis Asbestosis Baritosis Bauxite fibrosis Berylliosis Caplan's syndrome Chalicosis Coalworker's pneumoconiosis ( ...
Aplastic anemia Asbestosis Berylliosis Byssinosis Hodgkins disease Interstitial lung disease Leukemia Lymphoma Manganism ...
Malignancy Lymphoma Carcinoma Mediastinal tumors Inorganic dust disease Silicosis Berylliosis Extrinsic allergic alveolitis ...
... berylliosis) Pneumoconiosis (coal-worker's) A CHEST Arrhythmia/altered conscious level Cyanosis, PaCO2 normal Hypotension, ...
... or berylliosis, usually as a result of long-term exposure to beryllium oxide usually caused by inhalation. This article ...
... berylliosis MeSH C08.381.483.600.275 - byssinosis MeSH C08.381.483.600.300 - caplan's syndrome MeSH C08.381.483.600.750 - ...
... and cerebral calcification Berylliosis Beta ketothiolase deficiency Beta-galactosidase-1 deficiency Beta-mannosidosis Beta- ...
... bauxite Berylliosis - beryllium Siderosis - iron Byssinosis - cotton Silicosiderosis - mixed dust containing silica and iron ...
... berylliosis, byssinosis, coal dust pneumoconiosis, farmers' lung, hard metal pneumoconiosis, pleural and peritoneal ...
... berylliosis, histoplasmosis, Crohn's disease, and granulomatosis with polyangiitis) Idiopathic hypercalcaemia of infancy ...
... phlebitis of the portal vein granulomatous hepatitis berylliosis sarcoidosis nonalcoholic steatohepatitis (NASH) This may cause ...
... berylliosis MeSH C21.447.800.323 - byssinosis MeSH C21.447.800.340 - caplan's syndrome MeSH C21.447.800.773 - siderosis MeSH ...
Berylliosis. *Brucellosis. *Byssinosis ("brown lung"). *Chalicosis. *Chimney sweeps' carcinoma. *Chronic solvent-induced ...
Berylliosis. Caplan's syndrome. Chalicosis. Coalworker's pneumoconiosis. Siderosis. Silicosis. Talcosis. Byssinosis. ...
Berylliosis. Caplan's syndrome. Chalicosis. Coalworker's pneumoconiosis. Siderosis. Silicosis. Talcosis. Byssinosis. ...
Berylliosis. Caplan's syndrome. Chalicosis. Coalworker's pneumoconiosis. Siderosis. Silicosis. Talcosis. Byssinosis. ...
Berylliosis. *Brucellosis. *Byssinosis ("brown lung"). *Chalicosis. *Chimney sweeps' carcinoma. *Chronic solvent-induced ...
Berylliosis. Caplan's syndrome. Chalicosis. Coalworker's pneumoconiosis. Siderosis. Silicosis. Talcosis. Byssinosis. ...
Berylliosis. Caplan's syndrome. Chalicosis. Coalworker's pneumoconiosis. Siderosis. Silicosis. Talcosis. Byssinosis. ...
Berylliosis. *Brucellosis. *Byssinosis ("brown lung"). *Chalicosis. *Chimney sweeps' carcinoma. *Chronic solvent-induced ...
Berylliosis Definition Berylliosis is lung inflammation caused by inhaling dust or fumes that contain the metallic element ... Berylliosis. Definition. Berylliosis is lung inflammation caused by inhaling dust or fumes that contain the metallic element ... Acute berylliosis is a serious disease that occasionally may be fatal. Ventilators can help patients with acute berylliosis ... The symptoms of chronic berylliosis are largely the same as those seen in acute berylliosis, but they develop more slowly. ...
... or berylliosis. In acute beryllium disease, the metal acts as a direct chemical irritant, causing a nonspecific inflammatory ... encoded search term (Berylliosis) and Berylliosis What to Read Next on Medscape ... Berylliosis. Updated: Apr 30, 2020 * Author: Raed A Dweik, MD, MBA, FACP, FRCPC, FCCP, FCCM, FAHA; Chief Editor: Zab Mosenifar ... Sizar O, Talati R. Berylliosis (chronic beryllium disease). StatPearls [Internet]. 2020 Jan. [Medline]. [Full Text]. ...
Findings on CT are also not specific to berylliosis. Findings that are common in CT scans of people with berylliosis include ... Some studies suggest that up to 6% of all cases of sarcoidosis are actually berylliosis. Definitive diagnosis of berylliosis is ... Berylliosis is an occupational lung disease. While there is no cure, symptoms can be treated. With single or prolonged exposure ... Berylliosis, or chronic beryllium disease (CBD), is a chronic allergic-type lung response and chronic lung disease caused by ...
The primary outcome for the aims is the downregulation of Th1 cytokine TNFalpha with the inhibition of the JAK2 using siRNA and the inhibitor INCB018424, CEP-701 and TG101348 in CBD or overexpression of the JAK2 gene ...
... or berylliosis. In acute beryllium disease, the metal acts as a direct chemical irritant, causing a nonspecific inflammatory ... encoded search term (Berylliosis) and Berylliosis What to Read Next on Medscape. Related Conditions and Diseases. * Berylliosis ... Berylliosis Workup. Updated: Dec 31, 2015 * Author: Raed A Dweik, MD, MBA, FACP, FRCPC, FCCP, FCCM, FAHA; Chief Editor: Zab ...
IL-4 fails to regulate in vitro beryllium-induced cytokines in berylliosis.. ...
Discontinued Drugs for Berylliosis (Chronic Beryllium Disease), 2017 List of Chart. Berylliosis (Chronic Beryllium Disease) ... Berylliosis (Chronic Beryllium Disease) Therapeutic Market, US, Marketed Drugs by Application Type, 2017. Berylliosis (Chronic ... Berylliosis (Chronic Beryllium Disease) Marketed Drugs, API Manufacturers by US DMF Status, 2017. Berylliosis (Chronic ... Berylliosis (Chronic Beryllium Disease) Marketed Drugs, API Manufacturers by US DMF Status (%), 2017. Berylliosis (Chronic ...
Learn more about Berylliosis at Reston Hospital Center DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ... Berylliosis is a lung disease that affects people exposed to beryllium. Beryllium is a metallic element that is found in rocks ... Berylliosis is caused by inhalation of beryllium dust or fumes or other exposure such as through an open skin wound. ... Symptoms of chronic berylliosis may not appear until years after exposure. Therefore, all workers who may have been exposed to ...
I know some people are more likely to get berylliosis than others. Which ones? ...
it is also called berylliosis.. Beryllium is a naturally occurring lightweight material that can easily be inhaled in the forms ...
... external resources ICD-10 J63.2 ICD-9 503 Berylliosis or chronic beryllium disorder (CBD) is an occupational lung ... Berylliosis or chronic beryllium disorder (CBD) is an occupational lung disease. It is a chronic allergic-type lung response ... It uses material from the Wikipedia article "Berylliosis". A list of authors is available in Wikipedia. ... Pneumoconiosis (Coalworkers pneumoconiosis, Asbestosis, Silicosis, Bauxite fibrosis, Berylliosis, Siderosis) · Byssinosis · ...
... treatment, manifestations of the Berylliosis, Berylliosis race, Berylliosis function, Berylliosis care, Berylliosis ... Berylliosis case study, Berylliosis diet, Berylliosis subtypes, Berylliosis etymology, Berylliosis clinical trials, Berylliosis ... Berylliosis etiology, Berylliosis clinical features, Berylliosis test, Berylliosis introduction, Berylliosis types, Berylliosis ... Berylliosis medical care, Berylliosis testing, Berylliosis symptoms and signs, Berylliosis genetics, Berylliosis epidemiology, ...
A water soluble corticosteroid used to treat severe allergic reactions, dermatologic diseases, endocrine disorders, gastrointestinal diseases, hematological disorders, neoplastic diseases, nervous system conditions, ophthalmic diseases, renal diseases, respiratory diseases, and rheumatic disorders ...
Berylliosis. Symptomatic relief of acute manifestations of berylliosis.j. Aspiration Pneumonitis. Symptomatic relief of acute ...
Berylliosis. Symptomatic relief of acute manifestations of berylliosis.a d f m ...
... berylliosis explanation free. What is berylliosis? Meaning of berylliosis medical term. What does berylliosis mean? ... Looking for online definition of berylliosis in the Medical Dictionary? ... berylliosis. Also found in: Dictionary, Encyclopedia, Wikipedia. Berylliosis. Definition. Berylliosis is lung inflammation ... Acute berylliosis is a serious disease that occasionally may be fatal. Ventilators can help patients with acute berylliosis ...
Berylliosis is chronic damage to the lungs, also called chronic beryllium disease, resulting from industrial exposure to ... Berylliosis - Definition, Symptoms and Treatment. /Pulmonary System / Pulmonary Conditions / Berylliosis - Definition, Symptoms ... Definition of Berylliosis. Berylliosis is chronic damage to the LUNGS, also called chronic beryllium disease, resulting from ... Manufacturing Jobs with High Risk for Berylliosis. MANUFACTURING JOBS WITH HIGH RISK FOR BERYLLIOSIS. ...
Four More Questions About Berylliosis to Discuss With Your Doctor Five Questions About Berylliosis To Ask Your Doctor ...
... (Chronic Beryllium Disease): Read more about Symptoms, Diagnosis, Treatment, Complications, Causes and Prognosis. ... Berylliosis, also known as chronic beryllium disease (CBD), is a granulomatous lung disease caused by inhalation of beryllium ( ... Berylliosis is a chronic disease caused due to the heightened sensitivity of the immune system of the individual after repeated ... Berylliosis, also known as chronic beryllium disease (CBD), is a granulomatous lung disease caused by inhalation of beryllium ( ...
Berylliosis is a lung disease that affects people exposed to beryllium. Beryllium is a metallic element that is found in rocks ... Berylliosis is caused by inhalation of beryllium dust or fumes or other exposure such as through an open skin wound. ... Symptoms of chronic berylliosis may not appear until years after exposure. Therefore, all workers who may have been exposed to ... Symptoms of acute berylliosis come on suddenly and rapidly. The main symptoms are due to severe lung inflammation. These ...
Liver-disorders; Toxic-substances; Berylliosis; Enzyme-activity; Chlorinated-hydrocarbons; Light-metals; Metal-poisoning; Blood ...
Berylliosis: A disease of the lungs caused by inhaling small particles of the element beryllium.. Biopsy: A procedure in which ... and berylliosis (pronounced buh-ril-ee-O-suhs). The last two diseases are caused by inhaling certain minerals. These diseases ... such as silicosis and berylliosis, which are caused by inhalation of certain minerals, tuberculosis , and certain types of ... Inflammation and scar tissue are sometimes produced in the lung by diseases such as silicosis and berylliosis, which are caused ...
Berylliosis. D001607. EFO:0007168. berylliosis. 1. ClinicalTrials. Nutrition Disorders. D009748. EFO:0001069. nutritional ...
Berylliosis. * Graphite fibrosis (of lung) 516.0 Pneumoconiosis due to other inorganic dust *Aluminosis (of lung) ...
Berylliosis, a case report. Br Med J. 1955;1(4928):1448-50.CrossRefGoogle Scholar ... Berylliosis. Proc R Soc Med. 1955;48:175-7.PubMedGoogle Scholar ... Berylliosis; summary and survey of all clinical types observed ... In vitro demonstration of delayed hypersensitivity in patients with berylliosis. J Invest Dermatol. 1972;58:5-7.CrossRefGoogle ... Chronic beryllium disease (berylliosis). UpToDate 2016. Accessed 7 June 2016.Google Scholar ...
berylliosis. Berylliosis, systemic industrial disease caused by poisoning with beryllium, usually involving the lungs but ...
Berylliosis - Definition, Description, Causes and symptoms, Diagnosis, Treatment, Prognosis, Prevention. Berylliosis is lung ... Berylliosis occurs in both acute and chronic forms. In some cases, appearance of the disease may be delayed as much as 20 years ...
Contents: background; beryllium sensitization; diseases (berylliosis, cancer); medical surveillance; workplace surveys; case ...
Among people who work with beryllium, exposure can lead to berylliosis (also called chronic beryllium disease [CBD]), ...
  • Inhalation of beryllium (Be) has been associated with two pulmonary syndromes, which are an acute chemical pneumonitis and a granulomatous lung disease known as chronic beryllium disease (CBD), or berylliosis. (medscape.com)
  • A high-resolution CT scan of the chest showing the typical ground glass appearance in a patient with chronic beryllium disease, or berylliosis. (medscape.com)
  • A histopathology slide (hematosin and eosin stain) showing the typical well-formed granuloma of chronic beryllium disease, or berylliosis. (medscape.com)
  • DelveInsights, Berylliosis (Chronic Beryllium Disease) -API Insights, 2017 Report describes the current therapeutics that are propelling the pharmaceutical markets worldwide. (researchmoz.us)
  • The report gives the clear idea on the United States Drug Master File (USDMF) and Europe DMF filed by worldwide countries related to the Berylliosis (Chronic Beryllium Disease). (researchmoz.us)
  • A snapshot of the global Market therapeutics scenario for Berylliosis (Chronic Beryllium Disease). (researchmoz.us)
  • A review of the marketed products under prescription for Berylliosis (Chronic Beryllium Disease), regulatory information and marketing status. (researchmoz.us)
  • Product profiles for marketed products for Berylliosis (Chronic Beryllium Disease) with complete description of mechanism of action, therapeutic class, target, route(s) of administration and chemical details. (researchmoz.us)
  • Coverage of API Manufacturers for Berylliosis (Chronic Beryllium Disease) drugs in the United States, Europe and Asian Regions with location details. (researchmoz.us)
  • Coverage of Regulatory filings in the US, Europe, and Asia specifically India and China for Berylliosis (Chronic Beryllium Disease) drugs. (researchmoz.us)
  • Evaluate the marketing status and exclusivity details of Berylliosis (Chronic Beryllium Disease) key products to exploit opportunities for generic drug development opportunities. (researchmoz.us)
  • Design effective counter-strategies to gain competitive advantage by identifying the key patent expiry details and exclusivity with respect to Berylliosis (Chronic Beryllium Disease). (researchmoz.us)
  • API intelligence over marketed drugs for Berylliosis (Chronic Beryllium Disease) and gaining primary intelligence over active ingredients manufacturers across the globe. (researchmoz.us)
  • Berylliosis is chronic damage to the LUNGS , also called chronic beryllium disease, resulting from industrial exposure to beryllium, a heavy metal that has many commercial uses and applications in contemporary manufacturing processes. (beltina.org)
  • Berylliosis, also known as chronic beryllium disease (CBD), is a granulomatous lung disease caused by inhalation of beryllium (Be). (symptoma.com)
  • If you have been diagnosed with Berylliosis or Beryllium Disease within the last 3 years and it is associated with your past or present employment then contact LPS today. (lpsolicitors.co.uk)
  • What is Berylliosis / Beryllium Disease? (lpsolicitors.co.uk)
  • Berylliosis or Beryllium Disease is a chronic allergic-type lung response and chronic lung disease caused by exposure to beryllium and its compounds. (lpsolicitors.co.uk)
  • People exposed to beryllium dust often develop a lung illness called chronic beryllium disease, also known as berylliosis. (toledoblade.com)
  • How to determine whether I have sarcoidosis or berylliosis? (healthtap.com)
  • Granulomas are seen in other chronic diseases, such as tuberculosis and sarcoidosis, and it can occasionally be hard to distinguish berylliosis from these disorders. (chemeurope.com)
  • Conclusive diagnosis may require varied and numerous tests as well as thorough medical and personal histories, as berylliosis is similar to other interstitial lung diseases including sarcoidosis. (beltina.org)
  • Our differential diagnosis included chronic berylliosis, sarcoidosis and, less likely, malignancy and opportunistic infections. (ersjournals.com)
  • Others, such as asbestosis and berylliosis, result from occupational exposure and increase the risk of lung cancer and premature death. (pearsonitcertification.com)
  • Berylliosis occurs in both acute and chronic forms. (encyclopedia.com)
  • Chronic berylliosis is an allergic reaction to long-term exposure to even low levels of beryllium dust or fumes. (encyclopedia.com)
  • A systemic disease that causes formation of abnormal lung tissue and enlargement of the lymph nodes, chronic berylliosis also may affect other parts of the body. (encyclopedia.com)
  • The symptoms of chronic berylliosis are largely the same as those seen in acute berylliosis, but they develop more slowly. (encyclopedia.com)
  • Patients whose lungs are severely damaged by chronic berylliosis may experience fatal heart failure because of the strain placed on the heart. (encyclopedia.com)
  • Symptoms of chronic berylliosis develop slowly. (restonhospital.com)
  • Symptoms of chronic berylliosis may not appear until years after exposure. (restonhospital.com)
  • For chronic berylliosis, corticosteroids may be used if you develop symptoms of lung disease. (restonhospital.com)
  • Are chronic and acute berylliosis different? (healthtap.com)
  • Berylliosis or chronic beryllium disorder (CBD) is an occupational lung disease. (chemeurope.com)
  • Chronic Berylliosis is incurable but symptoms can be treated. (lpsolicitors.co.uk)
  • Chronic Berylliosis continues to occur in industries where beryllium is manufactured and processed and workers are exposed to beryllium fumes or dust. (lpsolicitors.co.uk)
  • A brief one-page report from Dr. Saab dated January 13, 2009 also provides a problem list indicating chronic berylliosis. (dol.gov)
  • FLiBe contains beryllium, which can lead to chronic berylliosis in a significant portion of the population. (energyfromthorium.com)
  • Berylliosis is a lung disease that affects people exposed to beryllium. (restonhospital.com)
  • However, berylliosis occurs only in people exposed to beryllium and nearly all such exposure is occupational, though beryllium is a natural mineral present in the environment. (beltina.org)
  • Coughing, shortness of breath, and weight loss that begin abruptly can be a symptom of acute berylliosis. (encyclopedia.com)
  • People who have acute berylliosis are usually very ill. (encyclopedia.com)
  • Acute berylliosis is a serious disease that occasionally may be fatal. (encyclopedia.com)
  • Ventilators can help patients with acute berylliosis breathe. (encyclopedia.com)
  • Most patients with acute berylliosis recover fully 7-10 days after treatment begins, and the disease usually causes no after effects. (encyclopedia.com)
  • Symptoms of acute berylliosis come on suddenly and rapidly. (restonhospital.com)
  • For acute berylliosis, you may be given corticosteroid medication. (restonhospital.com)
  • But in extreme cases, if not treated rapidly, acute berylliosis can be fatal. (restonhospital.com)
  • Acute berylliosis is a very serious disease that occasionally may lead to death. (illnessopedia.org)
  • Berylliosis results from delayed-type hypersensitivity (DTH) in which helper T-cell lymphocytes flood the sites of exposure and encase the beryllium dust particles or the areas of INFLAMMATION , causing granulomas to form. (beltina.org)
  • Individuals with beryllium sensitivity or early-stage berylliosis should be transferred from tasks that involve beryllium exposure and regularly examined to determine whether the disease has progressed. (encyclopedia.com)
  • Berylliosis is caused by inhalation of beryllium dust or fumes or other exposure such as through an open skin wound. (restonhospital.com)
  • Berylliosis, or CBD, is an occupationally acquired lung disease caused by exposure to beryllium, either by inhalation or contact through broken skin. (illnessopedia.org)
  • Berylliosis is caused by the inhalation of dust or fumes containing beryllium. (wikipedia.org)
  • It is estimated that 2-6% of workers exposed to these contaminants eventually develop berylliosis. (encyclopedia.com)
  • How and/or why did the patient develop berylliosis? (clinicaladvisor.com)
  • Eliminating exposure to beryllium is the surest way to prevent berylliosis. (encyclopedia.com)
  • Avoiding or limiting exposure to beryllium is the best way to prevent berylliosis. (restonhospital.com)
  • Berylliosis is initially suspected if a patient with symptoms of the disease has a history of beryllium exposure. (encyclopedia.com)
  • What are the symptoms of berylliosis? (healthtap.com)
  • What symptoms typically go along with berylliosis? (healthtap.com)
  • Berylliosis is incurable but its symptoms can be treated. (illnessopedia.org)
  • What is the definition or description of: Berylliosis? (healthtap.com)
  • Berylliosis is lung inflammation caused by inhaling dust or fumes that contain the metallic element beryllium. (encyclopedia.com)
  • If beryllium dust or fumes are inhaled, it can lead to an incurable inflammation of the lungs called berylliosis. (rsc.org)
  • A coronary consultation report dated April 8, 2009 from Dr. Aaron Adams states that the employee had tested positive per Dr. Saab for berylliosis but did not otherwise indicate that such a diagnosis had been confirmed, nor did he cite any test results supporting this diagnosis. (dol.gov)
  • The most important step in the management of berylliosis is to avoid further exposure to beryllium. (restonhospital.com)
  • In some individuals a single exposure can cause berylliosis. (chemeurope.com)
  • In some individuals a single exposure can already result to berylliosis. (illnessopedia.org)
  • Damage that does occur to the lungs is permanent and berylliosis is usually progressive, tending to continue even after exposure to beryllium ends. (beltina.org)
  • Berylliosis is a severe lung disease that results in scarring to the lungs and is caused by prolonged exposure to beryllium. (martinsonandbeason.com)
  • Available at: https://rarediseases.org/rare-diseases/berylliosis. (epnet.com)
  • Diseases associated with HLA-DPA1 include Berylliosis and Granulomatosis With Polyangiitis . (genecards.org)
  • Berylliosis usually only occurs in people who have an allergic sensitivity to beryllium. (restonhospital.com)
  • In the United States berylliosis occurs primarily in people who work in the electronics, nuclear, and aerospace industries where beryllium usage is high. (beltina.org)
  • Finally, one mutinous renegade realizes that high levels of beryllium in the soil caused the colonists to slowly die of berylliosis. (livescience.com)
  • She discovered that many of the workers contracted berylliosis. (wikipedia.org)
  • Patients affected by berylliosis experience cough and shortness of breath. (illnessopedia.org)
  • An overall population 36 berylliosis patients and 38 Be-sensitization without lung granulomas and 86 Be-exposed controls was analysed to assess the role of the individual HLA-class II polymorphisms associated with BH-susceptibility in HLA-DPGlu69 negative subjects by univariate and multivariate analysis. (cdc.gov)
  • The beryllium lymphocyte proliferation test (BeLPT), a blood test that can detect beryllium sensitivity (i.e. an allergic reaction to beryllium), is used to screen individuals at risk of developing berylliosis. (encyclopedia.com)
  • People who live near such industries have a slightly higher risk of getting berylliosis than those who do not, but the risk is extremely low. (restonhospital.com)
  • I know some people are more likely to get berylliosis than others. (healthtap.com)
  • LPS has dedicated Industrial Disease solicitors that have helped thousands of people successfully claim berylliosis compensation. (lpsolicitors.co.uk)
  • The results of the blood Be-LPT, performed in a single laboratory on 165 subjects (86 Be-exposed controls, 38 Be-sensitized without lung granulomas and 41 berylliosis cases) identified at a single large Be production factory, were analyzed for their realtionship with the HLA-DPGlu69 status as determined by high resolution HLA-DP typing. (cdc.gov)
  • The primary risk factor for berylliosis is working in an area where beryllium is processed. (restonhospital.com)
  • Who is at increased risk for developing berylliosis? (wordpress.com)
  • This test is now considered the most definitive diagnostic test for berylliosis. (encyclopedia.com)
  • If you have been diagnosed with Berylliosis, you may be able to claim compensation. (lpsolicitors.co.uk)
  • Recent research suggests GENETIC PREDISPOSITION underlies most cases of berylliosis, with mutations or defects affecting the MAJOR HISTOCOMPATABILITY COMPLEX (MHC) , which encodes aspects of immune response. (beltina.org)