Berylliosis
A form of pneumoconiosis caused by inhaled rare metal BERYLLIUM or its soluble salts which are used in a wide variety of industry including alloys, ceramics, radiographic equipment, and vacuum tubes. Berylliosis is characterized by an acute inflammatory reaction in the upper airway leading to BRONCHIOLITIS; PULMONARY EDEMA; and pneumonia.
Beryllium
HLA-DP Antigens
Chemical Hazard Release
Hantavirus Pulmonary Syndrome
Acute respiratory illness in humans caused by the Muerto Canyon virus whose primary rodent reservoir is the deer mouse Peromyscus maniculatus. First identified in the southwestern United States, this syndrome is characterized most commonly by fever, myalgias, headache, cough, and rapid respiratory failure.
Granuloma, Respiratory Tract
Tumor Necrosis Factor-alpha
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
Bronchoalveolar Lavage Fluid
Chronic Disease
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
Ebolavirus
Hemorrhagic Fever, Ebola
Endocrine System Diseases
Rheumatic Diseases
Chelation Therapy
Mustard Gas
Severe irritant and vesicant of skin, eyes, and lungs. It may cause blindness and lethal lung edema and was formerly used as a war gas. The substance has been proposed as a cytostatic and for treatment of psoriasis. It has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP-85-002, 1985) (Merck, 11th ed).
Iron Chelating Agents
Deferoxamine
World War II
Iron Overload
An excessive accumulation of iron in the body due to a greater than normal absorption of iron from the gastrointestinal tract or from parenteral injection. This may arise from idiopathic hemochromatosis, excessive iron intake, chronic alcoholism, certain types of refractory anemia, or transfusional hemosiderosis. (From Churchill's Illustrated Medical Dictionary, 1989)
Life Cycle Stages
Cell Cycle
The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.
Quality of Life
Internet
User-Computer Interface
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Software
Silicosis
Social Justice
Occupational Exposure
Pneumoconiosis
A diffuse parenchymal lung disease caused by inhalation of dust and by tissue reaction to their presence. These inorganic, organic, particulate, or vaporized matters usually are inhaled by workers in their occupational environment, leading to the various forms (ASBESTOSIS; BYSSINOSIS; and others). Similar air pollution can also have deleterious effects on the general population.
Asbestosis
Labor, Obstetric
Metals, Alkaline Earth
Elements
Metallurgy
The science, art, or technology dealing with processes involved in the separation of metals from their ores, the technique of making or compounding the alloys, the techniques of working or heat-treating metals, and the mining of metals. It includes industrial metallurgy as well as metallurgical techniques employed in the preparation and working of metals used in dentistry, with special reference to orthodontic and prosthodontic appliances. (From Jablonski, Dictionary of Dentistry, 1992, p494)
Silicon
Differential susceptibilities to chronic beryllium disease contributed by different Glu69 HLA-DPB1 and -DPA1 alleles. (1/92)
Chronic beryllium disease (CBD) is associated with the allelic substitution of a Glu69 in the HLA-DPB1 gene. Although up to 97% of CBD patients may have the Glu69 marker, about 30-45% of beryllium-exposed, unaffected individuals carry the same marker. Because CBD occurs in only 1-6% of exposed workers, the presence of Glu69 does not appear to be the sole genetic factor underlying the disease development. Using two rounds of direct automated DNA sequencing to precisely assign HLA-DPB1 haplotypes, we have discovered highly significant Glu69-containing allele frequency differences between the CBD patients and a beryllium-exposed, nondiseased control group. Individuals with DPB1 Glu69 in both alleles were almost exclusively found in the CBD group (6/20) vs the control group (1/75). Whereas most Glu69 carriers from the control group had a DPB1 allele *0201 (68%), most Glu69 carriers from the CBD group had a non-*0201 DPB1 Glu69-carrying allele (84%). The DPB1 allele *0201 was almost exclusively (29/30) associated with DPA1 *01 alleles, while the non-*0201 Glu69-containing DPB1 alleles were closely associated with DPA1 *02 alleles (26/29). Relatively rare Glu69-containing alleles *1701, *0901, and *1001 had extremely high frequencies in the CBD group (50%), as compared with the control group (6.7%). Therefore, the most common Glu69-containing DPB1 allele, *0201, does not seem to be a major disease allele. The results suggest that it is not the mere presence of Glu69, per se, but specific Glu69-containing alleles and their copy number (homozygous or heterozygous) that confer the greatest susceptibility to CBD in exposed individuals. (+info)Partial IL-10 inhibition of the cell-mediated immune response in chronic beryllium disease. (2/92)
Chronic beryllium disease (CBD) provides a human disorder in which to study the delayed type IV hypersensitivity response to persistent Ag that leads to noncaseating pulmonary granuloma formation. We hypothesized that, in CBD, failure of IL-10 to modulate the beryllium-specific, cell-mediated immune response would result in persistent, maximal cytokine production and T lymphocyte proliferation, thus contributing to the development of granulomatous lung disease. To test this hypothesis, we used bronchoalveolar lavage cells from control and CBD subjects to evaluate the beryllium salt-specific production of endogenous IL-10 and the effects of exogenous human rIL-10 (rhIL-10) on HLA expression, on the production of IL-2, IFN-gamma, and TNF-alpha, and on T lymphocyte proliferation. Our data demonstrate that beryllium-stimulated bronchoalveolar lavage cells produce IL-10, and the neutralization of endogenous IL-10 does not increase significantly cytokine production, HLA expression, or T lymphocyte proliferation. Second, the addition of excess exogenous rhIL-10 partially inhibited the beryllium-stimulated production of IL-2, IFN-gamma, and TNF-alpha; however, we measured no change in T lymphocyte proliferation or in the percentage of alveolar macrophages expressing HLA-DP. Interestingly, beryllium salts interfered with an IL-10-stimulated decrease in the percentage of alveolar macrophages expressing HLA-DR. We conclude that, in the CBD-derived, beryllium-stimulated cell-mediated immune response, low levels of endogenous IL-10 have no appreciable effect; exogenous rhIL-10 has a limited effect on cytokine production and no effect on T lymphocyte proliferation or HLA expression. (+info)Chronic beryllium disease and cancer risk estimates with uncertainty for beryllium released to the air from the Rocky Flats Plant. (3/92)
Beryllium was released into the air from routine operations and three accidental fires at the Rocky Flats Plant (RFP) in Colorado from 1958 to 1989. We evaluated environmental monitoring data and developed estimates of airborne concentrations and their uncertainties and calculated lifetime cancer risks and risks of chronic beryllium disease to hypothetical receptors. This article discusses exposure-response relationships for lung cancer and chronic beryllium disease. We assigned a distribution to cancer slope factor values based on the relative risk estimates from an occupational epidemiologic study used by the U.S. Environmental Protection Agency (EPA) to determine the slope factors. We used the regional atmospheric transport code for Hanford emission tracking atmospheric transport model for exposure calculations because it is particularly well suited for long-term annual-average dispersion estimates and it incorporates spatially varying meteorologic and environmental parameters. We accounted for model prediction uncertainty by using several multiplicative stochastic correction factors that accounted for uncertainty in the dispersion estimate, the meteorology, deposition, and plume depletion. We used Monte Carlo techniques to propagate model prediction uncertainty through to the final risk calculations. We developed nine exposure scenarios of hypothetical but typical residents of the RFP area to consider the lifestyle, time spent outdoors, location, age, and sex of people who may have been exposed. We determined geometric mean incremental lifetime cancer incidence risk estimates for beryllium inhalation for each scenario. The risk estimates were < 10(-6). Predicted air concentrations were well below the current reference concentration derived by the EPA for beryllium sensitization. (+info)Association of man-made mineral fibre exposure and sarcoidlike granulomas. (4/92)
It is assumed that sarcoidosis is caused by inhalation of air borne agents in susceptible persons triggering the inflammatory reaction. The association of metallic dust exposure, such as beryllium and aluminium, and sarcoidlike pulmonary disorders is well known. The ability of man-made mineral fibres (MMMF) to cause granulomatous lung disease has not been appreciated until now. Recently, we observed the association of sarcoidlike granulomatous reaction and occupational history of glass fibre exposure. We hypothesized that there might be a relationship between MMMF exposure and the development of sarcoidlike granulomas. Therefore, the records of 50 sarcoidosis patients-who visited our outpatient clinic between 1996 and 1999 were reviewed. This revealed that 14 cases recalled a history of exposure to either glass fibres or rock wool, both MMMF fibres. The available obtained tissue specimens (n = 12) were reviewed. In six cases electron microscopy qualitative analysis of small fragments of the tissue revealed among others silica, aluminium and sometimes titanium. A distinct relation between fibre deposits fibre deposits and granulomas was found. These findings indicate that in susceptible people MMMF exposure might be related to a chronic granulomatous disease similar to chronic beryllium disease. (+info)Government laboratory worker with lung cancer: comparing risks from beryllium, asbestos, and tobacco smoke. (5/92)
Occupational medicine physicians are frequently asked to establish cancer causation in patients with both workplace and non-workplace exposures. This is especially difficult in cases involving beryllium for which the data on human carcinogenicity are limited and controversial. In this report we present the case of a 73-year-old former technician at a government research facility who was recently diagnosed with lung cancer. The patient is a former smoker who has worked with both beryllium and asbestos. He was referred to the University of California, San Francisco, Occupational and Environmental Medicine Clinic at San Francisco General Hospital for an evaluation of whether past workplace exposures may have contributed to his current disease. The goal of this paper is to provide an example of the use of data-based risk estimates to determine causation in patients with multiple exposures. To do this, we review the current knowledge of lung cancer risks in former smokers and asbestos workers, and evaluate the controversies surrounding the epidemiologic data linking beryllium and cancer. Based on this information, we estimated that the patient's risk of lung cancer from asbestos was less than his risk from tobacco smoke, whereas his risk from beryllium was approximately equal to his risk from smoking. Based on these estimates, the patient's workplace was considered a probable contributing factor to his development of lung cancer. (+info)Beryllium presentation to CD4+ T cells underlies disease-susceptibility HLA-DP alleles in chronic beryllium disease. (6/92)
Chronic beryllium disease results from beryllium exposure in the workplace and is characterized by CD4(+) T cell-mediated inflammation in the lung. Susceptibility to this disease is associated with particular HLA-DP alleles. We isolated beryllium-specific T cell lines from the lungs of affected patients. These CD4(+) T cell lines specifically responded to beryllium in culture in the presence of antigen-presenting cells that expressed class II MHC molecules HLA-DR, -DQ, and -DP. The response to beryllium was nearly completely and selectively blocked by mAb to HLA-DP. Additional studies showed that only certain HLA-DP alleles allowed presentation of beryllium. Overall, the DP alleles that presented beryllium to disease-specific T cell lines match those implicated in disease susceptibility, providing a mechanism for this association. Based on amino acid residues shared by these restricting and susceptibility DP alleles, our results provide insight into the residues of the DP beta-chain required for beryllium presentation. (+info)HLA-DP allele-specific T cell responses to beryllium account for DP-associated susceptibility to chronic beryllium disease. (7/92)
Occupational exposure to small molecules, such as metals, is frequently associated with hypersensitivity reactions. Chronic beryllium (Be) disease (CBD) is a multisystem granulomatous disease that primarily affects the lung, and occurs in approximately 3% of individuals exposed to this element. Immunogenetic studies have demonstrated a strong association between CBD and possession of alleles of HLA-DP containing glutamic acid (Glu) at position 69 in the HLA-DP beta-chain. T cell clones were raised from three patients with CBD in whom exposure occurred 10 and 30 years previously. Of 25 Be-specific clones that were obtained, all were restricted by HLA-DP alleles with Glu at DP beta69. Furthermore, the proliferative responses of the clones were absolutely dependent upon DP beta Glu(69) in that a single amino acid substitution at this position abolished the response. As befits a disease whose pathogenesis involves a delayed type hypersensitivity response, the large majority of Be-specific clones secreted IFN-gamma (Th1) and little or no IL-4 (Th2) cytokines. This study provides insights into the molecular basis of DP2-associated susceptibility to CBD. (+info)IL-4 fails to regulate in vitro beryllium-induced cytokines in berylliosis. (8/92)
Bronchoalveolar lavage (BAL) cells from patients with chronic beryllium disease (CBD) have been used to evaluate the beryllium-specific immune response and potential immunotherapeutics. Beryllium induces interferon-gamma (IFN-gamma), interleukin-2 (IL-2), tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-10 (IL-10) from BAL cells. An antibody to IL-2 and recombinant human (rHu) IL-10 is able to partially suppress the beryllium-stimulated immune response. To obtain BAL cells, bronchoscopy is required, providing risk to the patient and a limited number of cells to study the immune response. As a result, the objectives of the study were to determine 1) whether CBD peripheral blood mononuclear cells (PBMNs) stimulated with beryllium would produce a similar cytokine pattern as BAL cells, and 2) whether this response could be modulated by interleukin-4 (IL-4), an immunomodulatory cytokine. CBD and normal individuals' PBMN and BAL cells were stimulated with and without beryllium sulfate. To modulate this antigen-stimulated response, we added rHu IL-4 to the unstimulated and beryllium-stimulated cells. IFN-gamma, IL-2, TNF-alpha, IL-6 and IL-10 cytokine concentrations were determined from cell supernatants by enzyme-linked immunosorbent assays (ELISA), while IL-4 messenger ribonucleic acid (mRNA) was assessed using polymerase chain reaction (PCR). Beryllium did not stimulate any of these cytokines from normal PBMNs. Increasing levels of IL-6 and TNF-alpha were produced constituitively by CBD PBMNs over time. Compared to the unstimulated CBD PBMNs, beryllium stimulated significant IFN-gamma, TNF-alpha, IL-2, IL-6 and IL-10 production. This response was similar to that stimulated from CBD BAL cells, although of a much lower magnitude. Low levels of IL-4 mRNA were found in CBD and control PBMNs, which were not increased with beryllium stimulation. The beryllium-stimulated cytokine levels were not decreased by the addition of IL-4. IL-4 was unable to downregulate any of these beryllium-stimulated cytokines from CBD BAL cells or increase IL-4 mRNA from either CBD PBMN or BAL cells, and thus is an unlikely immunomodulatory agent in CBD. From the data, it was concluded that chronic beryllium disease peripheral blood mononuclear cells provide a model to study the beryllium-stimulated immune response. Interleukin-4's inability to downregulate any of the beryllium-stimulated cytokines makes it an unlikely therapeutic candidate in chronic beryllium disease. (+info)
Treatment and Management of Chronic Beryllium Disease | Chronic Beryllium Disease
NIOSHTIC-2 Publications Search - 20022661 - HLA-DPB1 and chronic beryllium disease: a HuGE review.
Chronic Beryllium Disease (CBD) and Berryllium Sensitization
Genetic susceptibility in granulomatous disorders: chronic beryllium disease and sarcoidosis | HSTalks
Chronic Beryllium Disease (thing) by Somnia - Everything2.com
Berylliosis Workup: Laboratory Studies, Imaging Studies, Other Tests
Berylliosis: Background, Pathophysiology, Etiology
NIOSHTIC-2 Publications Search - 20032161 - IL-4 fails to regulate in vitro beryllium-induced cytokines in berylliosis.
Structural basis of chronic beryllium disease: linking allergic hypersensitivity and autoimmunity. | Sigma-Aldrich
Berylliosis | Reston Hospital Center
Berylliosis | Reston Hospital Center
Berylliosis | DrugBank Online
中国科学院水生生物研究所机构知识库(IHB OpenIR): Effects of anti-bursin monoclonal antibody on immunosuppression in the duck (Cherry Valley duck)
LymeMD: Lyme tests old and new
Review: The Summery of Studies Achievements on Aging Cell-Mdiated Immunity System by Cell Proliferation Tests - Archives of...
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Beryllium - SourceWatch
Plus it
Chapter 2: Chronic Beryllium Disease and Hanford - ProPublica
Beryllium Toolkit - OSAP
ATSDR - ToxFAQs™: Beryllium
Catch ⁹₄Be if you can : exploiting second-sphere hydrogen bonding toward chelation of beryllium : a thesis presented in partial...
Summary of lung function and beryllium exposure of case | Open-i
Risk of lung cancer associated with quantitative beryllium exposure metrics within an occupational cohort | GHDx
Lowering Limits: Changes to Beryllium Exposure Requirements | EC Mag
Ken Silver College of Public Health
EEOICP Decision 20120308-50279-1--20120522
Beryllium nitrate - Wikipedia
Deadline Approaching for Compliance with Most of OSHAs Beryllium Rules Requirements for General-Industry | ISRI
Nearly 2,000 people warned of possible beryllium exposure - CNN.com
5 Assessment of Other Health End Points | Health Effects of Beryllium Exposure: A Literature Review | The National Academies...
Front Matter | Health Effects of Beryllium Exposure: A Literature Review | The National Academies Press
Beryllium | Radiology Reference Article | Radiopaedia.org
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Effects of Beryllium on Human Serum Immunoglobulin and Lymphocyte Subpopulation - Semantic Scholar
USW Blasts Proposal to Cancel Beryllium Protections for Shipyard and Construction Workers - Press Releases
Occupational Exposure to Beryllium and Beryllium Compounds in Construction and Shipyard Sectors | Occupational Safety and...
Oral History | CSHL | Research | Mahlon Hoagland on Research on the Biological Effects of Beryllium
OSHA Enforcing New Beryllium Standards to Protect Workers
Global Beryllium Oxide (BeO) Powder Market 2017- Ulba Metallurgical Plant, Materion, China Minmetals
Beryllium workers get new protections after decades of delay - Chicago Tribune
Congress orders beryllium study - The Blade
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OSHA Issues Final Rule For Occupational Exposure To Beryllium - Employment and HR - United States
Beryllium Copper
Development of retrospective quantitative and qualitative job-exposure matrices for exposures at a beryllium processing...
What is the electron configuration of beryllium? | Reference.com
Beryllium Copper | Products & Suppliers | Engineering360
Extraction of cations as salts of fatty acids: beryllium as butyrate - Publications of the IAS Fellows
2010 - Johnson Matthey Pharmaceutical Materials, Inc.
Indian Patents. 234290:A DRESSING MATERIAL FOR TREATING OR ALLEVIATING DISEASES
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Beryllium | SSGCID
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Pit (nuclear weapon)
By the 1996, the US Department of Energy identified more than 50 cases of chronic berylliosis among nuclear industry employees ... Machining the tamper shells produces beryllium and beryllium oxide dust; its inhalation can cause berylliosis. ...
Harriet Louise Hardy
She discovered that many of the workers contracted berylliosis. Berylliosis is caused by the inhalation of dust or fumes ...
Schaumann body
Many conditions can cause Schaumann bodies, including: Sarcoidosis, Hypersensitivity pneumonitis, and Berylliosis. uncommonly, ...
Cavity magnetron
Single or chronic exposure can lead to berylliosis, an incurable lung condition. In addition, beryllia is listed as a confirmed ...
Period 2 element
Chronic berylliosis is a pulmonary and systemic granulomatous disease caused by exposure to beryllium. Between 1% - 15% of ... called chronic beryllium disease or berylliosis. The body's immune system recognises the beryllium as foreign particles and ...
MELISA
The LTT for beryllium is now accepted as the gold standard for diagnosing berylliosis. MELISA differs from standard LTTs in ...
Beryllium
Chronic berylliosis is a pulmonary and systemic granulomatous disease caused by inhalation of dust or fumes contaminated with ... Chronic berylliosis resembles sarcoidosis in many respects, and the differential diagnosis is often difficult. It killed some ... Because of this, inhalation of beryllium metal dust by people leads to the development of the fatal condition of berylliosis. ... Beryllium compounds were used in fluorescent lighting tubes, but this use was discontinued because of the disease berylliosis ...
Beryllium granuloma
Berylliosis is associated with exposure to beryllium in the beryllium mining, aerospace and manufacturing industries. Chronic ...
Beryllium oxide
BeO is carcinogenic in powdered form and may cause a chronic allergic-type lung disease berylliosis. Once fired into solid form ...
Kveim test
... may be used to distinguish sarcoidosis from conditions with otherwise indistinguishable symptoms such as berylliosis ...
Acute beryllium poisoning
... and is distinct from berylliosis (also called chronic beryllium disease). After occupational safety procedures were put into ... place following the realization that the metal caused berylliosis around 1950, acute beryllium poisoning became extremely rare ...
Herbert L. Anderson
His death was caused by lung failure, a derivative result of berylliosis-chronic beryllium poisoning, which he contracted ... returned there in 1978 as a fellow and then a senior fellow until his death from an almost forty-year struggle with berylliosis ...
W. W. Hansen
He died at age 39 in Palo Alto, California of berylliosis and fibrosis of the lungs, caused by inhaling the beryllium used in ...
Jörgen Nilsen Schaumann
... which are calcium-containing inclusion bodies found in the cytoplasm of giant cells in sarcoidosis and berylliosis. Schaumann ...
Calcitriol
... berylliosis Calcitriol increases blood calcium levels ([Ca2+ ]) by: Promoting absorption of dietary calcium from the ...
Progressive massive fibrosis
Conglomerate masses may also occur in other pneumoconioses, such as talcosis, berylliosis (CBD), kaolin pneumoconiosis, and ...
Occupational lung disease
Pneumoconiosis Asbestosis Baritosis Bauxite fibrosis Berylliosis Caplan's syndrome Chalicosis Coalworker's pneumoconiosis ( ...
Toxic tort
Aplastic anemia Asbestosis Berylliosis Byssinosis Hodgkins disease Interstitial lung disease Leukemia Lymphoma Manganism ...
List of diseases (C)
... monosomy 2q duplication 1p Chronic berylliosis Chronic bronchitis Chronic demyelinizing neuropathy with IgM monoclonal Chronic ...
Bilateral hilar lymphadenopathy
Malignancy Lymphoma Carcinoma Mediastinal tumors Inorganic dust disease Silicosis Berylliosis Extrinsic allergic alveolitis ...
List of medical mnemonics
... berylliosis) Pneumoconiosis (coal-worker's) A CHEST Arrhythmia/altered conscious level Cyanosis, PaCO2 normal Hypotension, ...
Beryllium poisoning
... or berylliosis, usually as a result of long-term exposure to beryllium oxide usually caused by inhalation. This article ...
List of MeSH codes (C08)
... berylliosis MeSH C08.381.483.600.275 - byssinosis MeSH C08.381.483.600.300 - caplan's syndrome MeSH C08.381.483.600.750 - ...
List of diseases (B)
... and cerebral calcification Berylliosis Beta ketothiolase deficiency Beta-galactosidase-1 deficiency Beta-mannosidosis Beta- ...
Pneumoconiosis
... bauxite Berylliosis - beryllium Siderosis - iron Byssinosis - cotton Silicosiderosis - mixed dust containing silica and iron ...
Dust Diseases Tribunal of New South Wales
... berylliosis, byssinosis, coal dust pneumoconiosis, farmers' lung, hard metal pneumoconiosis, pleural and peritoneal ...
Hypercalcaemia
... berylliosis, histoplasmosis, Crohn's disease, and granulomatosis with polyangiitis) Idiopathic hypercalcaemia of infancy ...
Interferon gamma
Examples of non-infectious granulomatous diseases are sarcoidosis, Crohn's disease, berylliosis, giant-cell arteritis, ...
List of hepato-biliary diseases
... phlebitis of the portal vein granulomatous hepatitis berylliosis sarcoidosis nonalcoholic steatohepatitis (NASH) This may cause ...
Granuloma
Examples of noninfectious granulomatous diseases are sarcoidosis, Crohn's disease, berylliosis, granulomatosis with ...
Berylliosis | Encyclopedia.com
Berylliosis Definition Berylliosis is lung inflammation caused by inhaling dust or fumes that contain the metallic element ... Berylliosis. Definition. Berylliosis is lung inflammation caused by inhaling dust or fumes that contain the metallic element ... Acute berylliosis is a serious disease that occasionally may be fatal. Ventilators can help patients with acute berylliosis ... The symptoms of chronic berylliosis are largely the same as those seen in acute berylliosis, but they develop more slowly. ...
Berylliosis - Wikipedia
Findings on CT are also not specific to berylliosis. Findings that are common in CT scans of people with berylliosis include ... Some studies suggest that up to 6% of all cases of sarcoidosis are actually berylliosis. Definitive diagnosis of berylliosis is ... Berylliosis is an occupational lung disease. While there is no cure, symptoms can be treated. With single or prolonged exposure ... Berylliosis, or chronic beryllium disease (CBD), is a chronic allergic-type lung response and chronic lung disease caused by ...
Berylliosis: Background, Pathophysiology, Etiology
... or berylliosis. In acute beryllium disease, the metal acts as a direct chemical irritant, causing a nonspecific inflammatory ... encoded search term (Berylliosis) and Berylliosis What to Read Next on Medscape ... Berylliosis. Updated: Apr 30, 2020 * Author: Raed A Dweik, MD, MBA, FACP, FRCPC, FCCP, FCCM, FAHA; Chief Editor: Zab Mosenifar ... Sizar O, Talati R. Berylliosis (chronic beryllium disease). StatPearls [Internet]. 2020 Jan. [Medline]. [Full Text]. ...
Search of: 'Berylliosis' - List Results - ClinicalTrials.gov
Berylliosis Workup: Laboratory Studies, Imaging Studies, Other Tests
... or berylliosis. In acute beryllium disease, the metal acts as a direct chemical irritant, causing a nonspecific inflammatory ... encoded search term (Berylliosis) and Berylliosis What to Read Next on Medscape. Related Conditions and Diseases. * Berylliosis ... Berylliosis Workup. Updated: Dec 31, 2015 * Author: Raed A Dweik, MD, MBA, FACP, FRCPC, FCCP, FCCM, FAHA; Chief Editor: Zab ...
NIOSHTIC-2 Publications Search - 20032161 - IL-4 fails to regulate in vitro beryllium-induced cytokines in berylliosis.
Berylliosis (Chronic Beryllium Disease)-API Insights, 2017
Discontinued Drugs for Berylliosis (Chronic Beryllium Disease), 2017 List of Chart. Berylliosis (Chronic Beryllium Disease) ... Berylliosis (Chronic Beryllium Disease) Therapeutic Market, US, Marketed Drugs by Application Type, 2017. Berylliosis (Chronic ... Berylliosis (Chronic Beryllium Disease) Marketed Drugs, API Manufacturers by US DMF Status, 2017. Berylliosis (Chronic ... Berylliosis (Chronic Beryllium Disease) Marketed Drugs, API Manufacturers by US DMF Status (%), 2017. Berylliosis (Chronic ...
Berylliosis | Reston Hospital Center
Learn more about Berylliosis at Reston Hospital Center DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ... Berylliosis is a lung disease that affects people exposed to beryllium. Beryllium is a metallic element that is found in rocks ... Berylliosis is caused by inhalation of beryllium dust or fumes or other exposure such as through an open skin wound. ... Symptoms of chronic berylliosis may not appear until years after exposure. Therefore, all workers who may have been exposed to ...
What are the tests for berylliosis? - Answered by top doctors on HealthTap
Chronic Beryllium Disease | Simple Guide to Understanding Berylliosis Disease
Berylliosis
... external resources ICD-10 J63.2 ICD-9 503 Berylliosis or chronic beryllium disorder (CBD) is an occupational lung ... Berylliosis or chronic beryllium disorder (CBD) is an occupational lung disease. It is a chronic allergic-type lung response ... It uses material from the Wikipedia article "Berylliosis". A list of authors is available in Wikipedia. ... Pneumoconiosis (Coalworkers pneumoconiosis, Asbestosis, Silicosis, Bauxite fibrosis, Berylliosis, Siderosis) · Byssinosis · ...
Berylliosis
... treatment, manifestations of the Berylliosis, Berylliosis race, Berylliosis function, Berylliosis care, Berylliosis ... Berylliosis case study, Berylliosis diet, Berylliosis subtypes, Berylliosis etymology, Berylliosis clinical trials, Berylliosis ... Berylliosis etiology, Berylliosis clinical features, Berylliosis test, Berylliosis introduction, Berylliosis types, Berylliosis ... Berylliosis medical care, Berylliosis testing, Berylliosis symptoms and signs, Berylliosis genetics, Berylliosis epidemiology, ...
Berylliosis | DrugBank Online
A water soluble corticosteroid used to treat severe allergic reactions, dermatologic diseases, endocrine disorders, gastrointestinal diseases, hematological disorders, neoplastic diseases, nervous system conditions, ophthalmic diseases, renal diseases, respiratory diseases, and rheumatic disorders ...
Triamcinolone Acetonide Monograph for Professionals - Drugs.com
Methylprednisolone Sodium Succinate Monograph for Professionals - Drugs.com
Berylliosis | definition of berylliosis by Medical dictionary
... berylliosis explanation free. What is berylliosis? Meaning of berylliosis medical term. What does berylliosis mean? ... Looking for online definition of berylliosis in the Medical Dictionary? ... berylliosis. Also found in: Dictionary, Encyclopedia, Wikipedia. Berylliosis. Definition. Berylliosis is lung inflammation ... Acute berylliosis is a serious disease that occasionally may be fatal. Ventilators can help patients with acute berylliosis ...
Berylliosis - Definition, Symptoms and Treatment | Beltina.org
Berylliosis is chronic damage to the lungs, also called chronic beryllium disease, resulting from industrial exposure to ... Berylliosis - Definition, Symptoms and Treatment. /Pulmonary System / Pulmonary Conditions / Berylliosis - Definition, Symptoms ... Definition of Berylliosis. Berylliosis is chronic damage to the LUNGS, also called chronic beryllium disease, resulting from ... Manufacturing Jobs with High Risk for Berylliosis. MANUFACTURING JOBS WITH HIGH RISK FOR BERYLLIOSIS. ...
Chelation Therapy: Natural Ways to Get Mercury, Lead, Beryllium and Other Harmful Substances Out of Your Body! - Page 2
Berylliosis
... (Chronic Beryllium Disease): Read more about Symptoms, Diagnosis, Treatment, Complications, Causes and Prognosis. ... Berylliosis, also known as chronic beryllium disease (CBD), is a granulomatous lung disease caused by inhalation of beryllium ( ... Berylliosis is a chronic disease caused due to the heightened sensitivity of the immune system of the individual after repeated ... Berylliosis, also known as chronic beryllium disease (CBD), is a granulomatous lung disease caused by inhalation of beryllium ( ...
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Berylliosis is a lung disease that affects people exposed to beryllium. Beryllium is a metallic element that is found in rocks ... Berylliosis is caused by inhalation of beryllium dust or fumes or other exposure such as through an open skin wound. ... Symptoms of chronic berylliosis may not appear until years after exposure. Therefore, all workers who may have been exposed to ... Symptoms of acute berylliosis come on suddenly and rapidly. The main symptoms are due to severe lung inflammation. These ...
NIOSHTIC-2 Publications Search - 00028867 - Comparative changes in serum enzyme levels in beryllium- or carbontetrachloride...
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Berylliosis: A disease of the lungs caused by inhaling small particles of the element beryllium.. Biopsy: A procedure in which ... and berylliosis (pronounced buh-ril-ee-O-suhs). The last two diseases are caused by inhaling certain minerals. These diseases ... such as silicosis and berylliosis, which are caused by inhalation of certain minerals, tuberculosis , and certain types of ... Inflammation and scar tissue are sometimes produced in the lung by diseases such as silicosis and berylliosis, which are caused ...
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Metal Allergy: Beryllium | SpringerLink
Berylliosis, a case report. Br Med J. 1955;1(4928):1448-50.CrossRefGoogle Scholar ... Berylliosis. Proc R Soc Med. 1955;48:175-7.PubMedGoogle Scholar ... Berylliosis; summary and survey of all clinical types observed ... In vitro demonstration of delayed hypersensitivity in patients with berylliosis. J Invest Dermatol. 1972;58:5-7.CrossRefGoogle ... Chronic beryllium disease (berylliosis). UpToDate 2016. Accessed 7 June 2016.Google Scholar ...
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CISDOC database
AsbestosisSarcoidosisAcuteExposed to berylliumEarly-stage berylliosisInhalationHypersensitivityCause berylliosisDevelop berylliosisPrevent berylliosisSymptomsDiagnosisDefinitionInflammationLungsGranulomasGENETIC PREDISPOSITIONExposureDiseasesBeryllium sensitivityOccupationalOccursDefinitiveParenchymalSeverePatientsIndividualsPeopleLeadDrugsDrugRiskChest
Asbestosis1
- Others, such as asbestosis and berylliosis, result from occupational exposure and increase the risk of lung cancer and premature death. (pearsonitcertification.com)
Sarcoidosis7
- Granulomas are seen in other chronic diseases, such as tuberculosis and sarcoidosis, and it can occasionally be hard to distinguish berylliosis from these disorders. (wikipedia.org)
- The differential diagnosis for berylliosis includes: Sarcoidosis Granulomatous lung diseases Tuberculosis Fungal infections (e.g., histoplasmosis) Granulomatosis with polyangiitis Idiopathic pulmonary fibrosis Hypersensitivity pneumonitis Asthma Of these possibilities, berylliosis presents most similarly to sarcoidosis. (wikipedia.org)
- Some studies suggest that up to 6% of all cases of sarcoidosis are actually berylliosis. (wikipedia.org)
- One study found that ground-glass opacities were more commonly seen on CT scan in berylliosis than in sarcoidosis. (wikipedia.org)
- How to determine whether I have sarcoidosis or berylliosis? (healthtap.com)
- Conclusive diagnosis may require varied and numerous tests as well as thorough medical and personal histories, as berylliosis is similar to other interstitial lung diseases including sarcoidosis. (beltina.org)
- Our differential diagnosis included chronic berylliosis, sarcoidosis and, less likely, malignancy and opportunistic infections. (ersjournals.com)
Acute14
- Berylliosis occurs in both acute and chronic forms. (encyclopedia.com)
- Coughing, shortness of breath, and weight loss that begin abruptly can be a symptom of acute berylliosis. (encyclopedia.com)
- People who have acute berylliosis are usually very ill. (encyclopedia.com)
- The symptoms of chronic berylliosis are largely the same as those seen in acute berylliosis, but they develop more slowly. (encyclopedia.com)
- Acute berylliosis is a serious disease that occasionally may be fatal. (encyclopedia.com)
- Ventilators can help patients with acute berylliosis breathe. (encyclopedia.com)
- Most patients with acute berylliosis recover fully 7-10 days after treatment begins, and the disease usually causes no after effects. (encyclopedia.com)
- Inhalation of beryllium (Be) has been associated with two pulmonary syndromes, which are an acute chemical pneumonitis and a granulomatous lung disease known as chronic beryllium disease (CBD), or berylliosis. (medscape.com)
- Symptoms of acute berylliosis come on suddenly and rapidly. (restonhospital.com)
- For acute berylliosis, you may be given corticosteroid medication. (restonhospital.com)
- But in extreme cases, if not treated rapidly, acute berylliosis can be fatal. (restonhospital.com)
- Are chronic and acute berylliosis different? (healthtap.com)
- Acute berylliosis is a very serious disease that occasionally may lead to death. (illnessopedia.org)
- With the introduction of Be-exposure standards in 1949, the occurrence of acute berylliosis was virtually eliminated, but cases of chronic Be disease (CBD) continue to occur. (jimmunol.org)
Exposed to beryllium4
- Berylliosis is a lung disease that affects people exposed to beryllium. (restonhospital.com)
- However, berylliosis occurs only in people exposed to beryllium and nearly all such exposure is occupational, though beryllium is a natural mineral present in the environment. (beltina.org)
- Chronic Berylliosis continues to occur in industries where beryllium is manufactured and processed and workers are exposed to beryllium fumes or dust. (lpsolicitors.co.uk)
- People exposed to beryllium dust often develop a lung illness called chronic beryllium disease, also known as berylliosis. (toledoblade.com)
Early-stage berylliosis1
- Individuals with beryllium sensitivity or early-stage berylliosis should be transferred from tasks that involve beryllium exposure and regularly examined to determine whether the disease has progressed. (encyclopedia.com)
Inhalation3
- Berylliosis is caused by inhalation of beryllium dust or fumes or other exposure such as through an open skin wound. (restonhospital.com)
- Berylliosis, or CBD, is an occupationally acquired lung disease caused by exposure to beryllium, either by inhalation or contact through broken skin. (illnessopedia.org)
- Berylliosis, also known as chronic beryllium disease (CBD), is a granulomatous lung disease caused by inhalation of beryllium (Be). (symptoma.com)
Hypersensitivity1
- Berylliosis results from delayed-type hypersensitivity (DTH) in which helper T-cell lymphocytes flood the sites of exposure and encase the beryllium dust particles or the areas of INFLAMMATION , causing granulomas to form. (beltina.org)
Cause berylliosis2
- In some individuals, a single exposure to beryllium can cause berylliosis. (wikipedia.org)
- In some individuals a single exposure can cause berylliosis. (chemeurope.com)
Develop berylliosis2
- It is estimated that 2-6% of workers exposed to these contaminants eventually develop berylliosis. (encyclopedia.com)
- How and/or why did the patient develop berylliosis? (clinicaladvisor.com)
Prevent berylliosis2
- Eliminating exposure to beryllium is the surest way to prevent berylliosis. (encyclopedia.com)
- Avoiding or limiting exposure to beryllium is the best way to prevent berylliosis. (restonhospital.com)
Symptoms8
- Berylliosis is initially suspected if a patient with symptoms of the disease has a history of beryllium exposure. (encyclopedia.com)
- Symptoms of chronic berylliosis develop slowly. (restonhospital.com)
- Symptoms of chronic berylliosis may not appear until years after exposure. (restonhospital.com)
- For chronic berylliosis, corticosteroids may be used if you develop symptoms of lung disease. (restonhospital.com)
- What are the symptoms of berylliosis? (healthtap.com)
- What symptoms typically go along with berylliosis? (healthtap.com)
- Berylliosis is incurable but its symptoms can be treated. (illnessopedia.org)
- Chronic Berylliosis is incurable but symptoms can be treated. (lpsolicitors.co.uk)
Diagnosis3
- Definitive diagnosis of berylliosis is based on history of beryllium exposures, documented beryllium sensitivity and granulomatous inflammation on lung biopsy. (wikipedia.org)
- Given the invasive nature of a lung biopsy, diagnosis can also be based on clinical history consistent with berylliosis, abnormal chest x-ray or CT scan findings, and abnormalities in pulmonary function tests. (wikipedia.org)
- A coronary consultation report dated April 8, 2009 from Dr. Aaron Adams states that the employee had tested positive per Dr. Saab for berylliosis but did not otherwise indicate that such a diagnosis had been confirmed, nor did he cite any test results supporting this diagnosis. (dol.gov)
Definition1
- What is the definition or description of: Berylliosis? (healthtap.com)
Inflammation2
- Berylliosis is lung inflammation caused by inhaling dust or fumes that contain the metallic element beryllium. (encyclopedia.com)
- If beryllium dust or fumes are inhaled, it can lead to an incurable inflammation of the lungs called berylliosis. (rsc.org)
Lungs4
- Patients whose lungs are severely damaged by chronic berylliosis may experience fatal heart failure because of the strain placed on the heart. (encyclopedia.com)
- Berylliosis is chronic damage to the LUNGS , also called chronic beryllium disease, resulting from industrial exposure to beryllium, a heavy metal that has many commercial uses and applications in contemporary manufacturing processes. (beltina.org)
- Damage that does occur to the lungs is permanent and berylliosis is usually progressive, tending to continue even after exposure to beryllium ends. (beltina.org)
- Berylliosis is a severe lung disease that results in scarring to the lungs and is caused by prolonged exposure to beryllium. (martinsonandbeason.com)
Granulomas2
- The results of the blood Be-LPT, performed in a single laboratory on 165 subjects (86 Be-exposed controls, 38 Be-sensitized without lung granulomas and 41 berylliosis cases) identified at a single large Be production factory, were analyzed for their realtionship with the HLA-DPGlu69 status as determined by high resolution HLA-DP typing. (cdc.gov)
- An overall population 36 berylliosis patients and 38 Be-sensitization without lung granulomas and 86 Be-exposed controls was analysed to assess the role of the individual HLA-class II polymorphisms associated with BH-susceptibility in HLA-DPGlu69 negative subjects by univariate and multivariate analysis. (cdc.gov)
GENETIC PREDISPOSITION2
- Genetic predisposition seems to have play a majot role in the development of berylliosis. (illnessopedia.org)
- Recent research suggests GENETIC PREDISPOSITION underlies most cases of berylliosis, with mutations or defects affecting the MAJOR HISTOCOMPATABILITY COMPLEX (MHC) , which encodes aspects of immune response. (beltina.org)
Exposure3
- Chronic berylliosis is an allergic reaction to long-term exposure to even low levels of beryllium dust or fumes. (encyclopedia.com)
- Berylliosis, or chronic beryllium disease (CBD), is a chronic allergic-type lung response and chronic lung disease caused by exposure to beryllium and its compounds, a form of beryllium poisoning. (wikipedia.org)
- The most important step in the management of berylliosis is to avoid further exposure to beryllium. (restonhospital.com)
Diseases2
- Available at: https://rarediseases.org/rare-diseases/berylliosis. (epnet.com)
- Diseases associated with HLA-DPA1 include Berylliosis and Granulomatosis With Polyangiitis . (genecards.org)
Beryllium sensitivity1
- The beryllium lymphocyte proliferation test (BeLPT), a blood test that can detect beryllium sensitivity (i.e. an allergic reaction to beryllium), is used to screen individuals at risk of developing berylliosis. (encyclopedia.com)
Occupational2
- Berylliosis is an occupational lung disease. (wikipedia.org)
- Berylliosis or chronic beryllium disorder (CBD) is an occupational lung disease. (chemeurope.com)
Occurs2
- Berylliosis usually only occurs in people who have an allergic sensitivity to beryllium. (restonhospital.com)
- In the United States berylliosis occurs primarily in people who work in the electronics, nuclear, and aerospace industries where beryllium usage is high. (beltina.org)
Definitive1
- This test is now considered the most definitive diagnostic test for berylliosis. (encyclopedia.com)
Parenchymal1
- Findings that are common in CT scans of people with berylliosis include parenchymal nodules in early stages. (wikipedia.org)
Severe1
- In severe cases, berylliosis may lead to heart failure . (restonhospital.com)
Patients1
- Patients affected by berylliosis experience cough and shortness of breath. (illnessopedia.org)
Individuals1
- Which individuals are at greatest risk of developing berylliosis? (clinicaladvisor.com)
People3
- People who live near such industries have a slightly higher risk of getting berylliosis than those who do not, but the risk is extremely low. (restonhospital.com)
- I know some people are more likely to get berylliosis than others. (healthtap.com)
- LPS has dedicated Industrial Disease solicitors that have helped thousands of people successfully claim berylliosis compensation. (lpsolicitors.co.uk)
Lead1
- FLiBe contains beryllium, which can lead to chronic berylliosis in a significant portion of the population. (energyfromthorium.com)
Drugs3
- Coverage of API Manufacturers for Berylliosis (Chronic Beryllium Disease) drugs in the United States, Europe and Asian Regions with location details. (researchmoz.us)
- Coverage of Regulatory filings in the US, Europe, and Asia specifically India and China for Berylliosis (Chronic Beryllium Disease) drugs. (researchmoz.us)
- API intelligence over marketed drugs for Berylliosis (Chronic Beryllium Disease) and gaining primary intelligence over active ingredients manufacturers across the globe. (researchmoz.us)
Drug2
- The report gives the clear idea on the United States Drug Master File (USDMF) and Europe DMF filed by worldwide countries related to the Berylliosis (Chronic Beryllium Disease). (researchmoz.us)
- Evaluate the marketing status and exclusivity details of Berylliosis (Chronic Beryllium Disease) key products to exploit opportunities for generic drug development opportunities. (researchmoz.us)
Risk2
- The primary risk factor for berylliosis is working in an area where beryllium is processed. (restonhospital.com)
- Who is at increased risk for developing berylliosis? (wordpress.com)
Chest2
- Chest radiography findings of berylliosis are non-specific. (wikipedia.org)
- A high-resolution CT scan of the chest showing the typical ground glass appearance in a patient with chronic beryllium disease, or berylliosis. (medscape.com)