Berylliosis: A form of pneumoconiosis caused by inhaled rare metal BERYLLIUM or its soluble salts which are used in a wide variety of industry including alloys, ceramics, radiographic equipment, and vacuum tubes. Berylliosis is characterized by an acute inflammatory reaction in the upper airway leading to BRONCHIOLITIS; PULMONARY EDEMA; and pneumonia.Beryllium: Beryllium. An element with the atomic symbol Be, atomic number 4, and atomic weight 9.01218. Short exposure to this element can lead to a type of poisoning known as BERYLLIOSIS.HLA-DP Antigens: A group of the D-related HLA antigens (human) found to differ from the DR antigens in genetic locus and therefore inheritance. These antigens are polymorphic glycoproteins comprising alpha and beta chains and are found on lymphoid and other cells, often associated with certain diseases.Chemical Hazard Release: Uncontrolled release of a chemical from its containment that either threatens to, or does, cause exposure to a chemical hazard. Such an incident may occur accidentally or deliberately.HLA-DP beta-Chains: Transmembrane proteins that form the beta subunits of the HLA-DP antigens.Hantavirus Pulmonary Syndrome: Acute respiratory illness in humans caused by the Muerto Canyon virus whose primary rodent reservoir is the deer mouse Peromyscus maniculatus. First identified in the southwestern United States, this syndrome is characterized most commonly by fever, myalgias, headache, cough, and rapid respiratory failure.Granuloma, Respiratory Tract: Granulomatous disorders affecting one or more sites in the respiratory tract.Tumor Necrosis Factor-alpha: Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.Bronchoalveolar Lavage Fluid: Washing liquid obtained from irrigation of the lung, including the BRONCHI and the PULMONARY ALVEOLI. It is generally used to assess biochemical, inflammatory, or infection status of the lung.Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)Croatia: Created 7 April 1992 as a result of the division of Yugoslavia.Ebolavirus: A genus in the family FILOVIRIDAE consisting of several distinct species of Ebolavirus, each containing separate strains. These viruses cause outbreaks of a contagious, hemorrhagic disease (HEMORRHAGIC FEVER, EBOLA) in humans, usually with high mortality.Hemorrhagic Fever, Ebola: A highly fatal, acute hemorrhagic fever, clinically very similar to MARBURG VIRUS DISEASE, caused by EBOLAVIRUS, first occurring in the Sudan and adjacent northwestern (what was then) Zaire.New York CityChelation Therapy: Therapy of heavy metal poisoning using agents which sequester the metal from organs or tissues and bind it firmly within the ring structure of a new compound which can be eliminated from the body.Mustard Gas: Severe irritant and vesicant of skin, eyes, and lungs. It may cause blindness and lethal lung edema and was formerly used as a war gas. The substance has been proposed as a cytostatic and for treatment of psoriasis. It has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP-85-002, 1985) (Merck, 11th ed).Iron Chelating Agents: Organic chemicals that form two or more coordination links with an iron ion. Once coordination has occurred, the complex formed is called a chelate. The iron-binding porphyrin group of hemoglobin is an example of a metal chelate found in biological systems.Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.World War II: Global conflict involving countries of Europe, Africa, Asia, and North America that occurred between 1939 and 1945.Iron Overload: An excessive accumulation of iron in the body due to a greater than normal absorption of iron from the gastrointestinal tract or from parenteral injection. This may arise from idiopathic hemochromatosis, excessive iron intake, chronic alcoholism, certain types of refractory anemia, or transfusional hemosiderosis. (From Churchill's Illustrated Medical Dictionary, 1989)Metals, Alkaline Earth: Metals that constitute the group 2 (formerly group IIa) of the periodic table.Elements: Substances that comprise all matter. Each element is made up of atoms that are identical in number of electrons and protons and in nuclear charge, but may differ in mass or number of neutrons.Metallurgy: The science, art, or technology dealing with processes involved in the separation of metals from their ores, the technique of making or compounding the alloys, the techniques of working or heat-treating metals, and the mining of metals. It includes industrial metallurgy as well as metallurgical techniques employed in the preparation and working of metals used in dentistry, with special reference to orthodontic and prosthodontic appliances. (From Jablonski, Dictionary of Dentistry, 1992, p494)Silicon: A trace element that constitutes about 27.6% of the earth's crust in the form of SILICON DIOXIDE. It does not occur free in nature. Silicon has the atomic symbol Si, atomic number 14, and atomic weight [28.084; 28.086].Viral Structures: The structural parts of the VIRION.Methylprednisolone: A PREDNISOLONE derivative with similar anti-inflammatory action.Methylprednisolone Hemisuccinate: A water-soluble ester of METHYLPREDNISOLONE used for cardiac, allergic, and hypoxic emergencies.Tablets: Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)Gene Dosage: The number of copies of a given gene present in the cell of an organism. An increase in gene dosage (by GENE DUPLICATION for example) can result in higher levels of gene product formation. GENE DOSAGE COMPENSATION mechanisms result in adjustments to the level GENE EXPRESSION when there are changes or differences in gene dosage.Diagnostic Techniques, Neurological: Methods and procedures for the diagnosis of diseases of the nervous system, central and peripheral, or demonstration of neurologic function or dysfunction.Pulse Therapy, Drug: Administration of high doses of pharmaceuticals over short periods of time.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)UDPglucose 4-Epimerase: A necessary enzyme in the metabolism of galactose. It reversibly catalyzes the conversion of UDPglucose to UDPgalactose. NAD+ is an essential component for enzymatic activity. EC 5.1.3.2.EncyclopediasTh2 Cells: Subset of helper-inducer T-lymphocytes which synthesize and secrete the interleukins IL-4, IL-5, IL-6, and IL-10. These cytokines influence B-cell development and antibody production as well as augmenting humoral responses.Th1 Cells: Subset of helper-inducer T-lymphocytes which synthesize and secrete interleukin-2, gamma-interferon, and interleukin-12. Due to their ability to kill antigen-presenting cells and their lymphokine-mediated effector activity, Th1 cells are associated with vigorous delayed-type hypersensitivity reactions.Manuals as Topic: Books designed to give factual information or instructions.Molecular Sequence Annotation: The addition of descriptive information about the function or structure of a molecular sequence to its MOLECULAR SEQUENCE DATA record.Cranial Nerve Diseases: Disorders of one or more of the twelve cranial nerves. With the exception of the optic and olfactory nerves, this includes disorders of the brain stem nuclei from which the cranial nerves originate or terminate.Arthrogryposis: Persistent flexure or contracture of a joint.Phosphorus Metabolism Disorders: Disorders in the processing of phosphorus in the body: its absorption, transport, storage, and utilization.Cranial Nerves: Twelve pairs of nerves that carry general afferent, visceral afferent, special afferent, somatic efferent, and autonomic efferent fibers.Abducens Nerve Diseases: Diseases of the sixth cranial (abducens) nerve or its nucleus in the pons. The nerve may be injured along its course in the pons, intracranially as it travels along the base of the brain, in the cavernous sinus, or at the level of superior orbital fissure or orbit. Dysfunction of the nerve causes lateral rectus muscle weakness, resulting in horizontal diplopia that is maximal when the affected eye is abducted and ESOTROPIA. Common conditions associated with nerve injury include INTRACRANIAL HYPERTENSION; CRANIOCEREBRAL TRAUMA; ISCHEMIA; and INFRATENTORIAL NEOPLASMS.Oculomotor Nerve Diseases: Diseases of the oculomotor nerve or nucleus that result in weakness or paralysis of the superior rectus, inferior rectus, medial rectus, inferior oblique, or levator palpebrae muscles, or impaired parasympathetic innervation to the pupil. With a complete oculomotor palsy, the eyelid will be paralyzed, the eye will be in an abducted and inferior position, and the pupil will be markedly dilated. Commonly associated conditions include neoplasms, CRANIOCEREBRAL TRAUMA, ischemia (especially in association with DIABETES MELLITUS), and aneurysmal compression. (From Adams et al., Principles of Neurology, 6th ed, p270)Diagnostic Errors: Incorrect diagnoses after clinical examination or technical diagnostic procedures.Iritis: Inflammation of the iris characterized by circumcorneal injection, aqueous flare, keratotic precipitates, and constricted and sluggish pupil along with discoloration of the iris.Blister: Visible accumulations of fluid within or beneath the epidermis.ConjunctivitisCellulitis: An acute, diffuse, and suppurative inflammation of loose connective tissue, particularly the deep subcutaneous tissues, and sometimes muscle, which is most commonly seen as a result of infection of a wound, ulcer, or other skin lesions.Abdomen, Acute: A clinical syndrome with acute abdominal pain that is severe, localized, and rapid in onset. Acute abdomen may be caused by a variety of disorders, injuries, or diseases.Abdomen: That portion of the body that lies between the THORAX and the PELVIS.

Differential susceptibilities to chronic beryllium disease contributed by different Glu69 HLA-DPB1 and -DPA1 alleles. (1/92)

Chronic beryllium disease (CBD) is associated with the allelic substitution of a Glu69 in the HLA-DPB1 gene. Although up to 97% of CBD patients may have the Glu69 marker, about 30-45% of beryllium-exposed, unaffected individuals carry the same marker. Because CBD occurs in only 1-6% of exposed workers, the presence of Glu69 does not appear to be the sole genetic factor underlying the disease development. Using two rounds of direct automated DNA sequencing to precisely assign HLA-DPB1 haplotypes, we have discovered highly significant Glu69-containing allele frequency differences between the CBD patients and a beryllium-exposed, nondiseased control group. Individuals with DPB1 Glu69 in both alleles were almost exclusively found in the CBD group (6/20) vs the control group (1/75). Whereas most Glu69 carriers from the control group had a DPB1 allele *0201 (68%), most Glu69 carriers from the CBD group had a non-*0201 DPB1 Glu69-carrying allele (84%). The DPB1 allele *0201 was almost exclusively (29/30) associated with DPA1 *01 alleles, while the non-*0201 Glu69-containing DPB1 alleles were closely associated with DPA1 *02 alleles (26/29). Relatively rare Glu69-containing alleles *1701, *0901, and *1001 had extremely high frequencies in the CBD group (50%), as compared with the control group (6.7%). Therefore, the most common Glu69-containing DPB1 allele, *0201, does not seem to be a major disease allele. The results suggest that it is not the mere presence of Glu69, per se, but specific Glu69-containing alleles and their copy number (homozygous or heterozygous) that confer the greatest susceptibility to CBD in exposed individuals.  (+info)

Partial IL-10 inhibition of the cell-mediated immune response in chronic beryllium disease. (2/92)

Chronic beryllium disease (CBD) provides a human disorder in which to study the delayed type IV hypersensitivity response to persistent Ag that leads to noncaseating pulmonary granuloma formation. We hypothesized that, in CBD, failure of IL-10 to modulate the beryllium-specific, cell-mediated immune response would result in persistent, maximal cytokine production and T lymphocyte proliferation, thus contributing to the development of granulomatous lung disease. To test this hypothesis, we used bronchoalveolar lavage cells from control and CBD subjects to evaluate the beryllium salt-specific production of endogenous IL-10 and the effects of exogenous human rIL-10 (rhIL-10) on HLA expression, on the production of IL-2, IFN-gamma, and TNF-alpha, and on T lymphocyte proliferation. Our data demonstrate that beryllium-stimulated bronchoalveolar lavage cells produce IL-10, and the neutralization of endogenous IL-10 does not increase significantly cytokine production, HLA expression, or T lymphocyte proliferation. Second, the addition of excess exogenous rhIL-10 partially inhibited the beryllium-stimulated production of IL-2, IFN-gamma, and TNF-alpha; however, we measured no change in T lymphocyte proliferation or in the percentage of alveolar macrophages expressing HLA-DP. Interestingly, beryllium salts interfered with an IL-10-stimulated decrease in the percentage of alveolar macrophages expressing HLA-DR. We conclude that, in the CBD-derived, beryllium-stimulated cell-mediated immune response, low levels of endogenous IL-10 have no appreciable effect; exogenous rhIL-10 has a limited effect on cytokine production and no effect on T lymphocyte proliferation or HLA expression.  (+info)

Chronic beryllium disease and cancer risk estimates with uncertainty for beryllium released to the air from the Rocky Flats Plant. (3/92)

Beryllium was released into the air from routine operations and three accidental fires at the Rocky Flats Plant (RFP) in Colorado from 1958 to 1989. We evaluated environmental monitoring data and developed estimates of airborne concentrations and their uncertainties and calculated lifetime cancer risks and risks of chronic beryllium disease to hypothetical receptors. This article discusses exposure-response relationships for lung cancer and chronic beryllium disease. We assigned a distribution to cancer slope factor values based on the relative risk estimates from an occupational epidemiologic study used by the U.S. Environmental Protection Agency (EPA) to determine the slope factors. We used the regional atmospheric transport code for Hanford emission tracking atmospheric transport model for exposure calculations because it is particularly well suited for long-term annual-average dispersion estimates and it incorporates spatially varying meteorologic and environmental parameters. We accounted for model prediction uncertainty by using several multiplicative stochastic correction factors that accounted for uncertainty in the dispersion estimate, the meteorology, deposition, and plume depletion. We used Monte Carlo techniques to propagate model prediction uncertainty through to the final risk calculations. We developed nine exposure scenarios of hypothetical but typical residents of the RFP area to consider the lifestyle, time spent outdoors, location, age, and sex of people who may have been exposed. We determined geometric mean incremental lifetime cancer incidence risk estimates for beryllium inhalation for each scenario. The risk estimates were < 10(-6). Predicted air concentrations were well below the current reference concentration derived by the EPA for beryllium sensitization.  (+info)

Association of man-made mineral fibre exposure and sarcoidlike granulomas. (4/92)

It is assumed that sarcoidosis is caused by inhalation of air borne agents in susceptible persons triggering the inflammatory reaction. The association of metallic dust exposure, such as beryllium and aluminium, and sarcoidlike pulmonary disorders is well known. The ability of man-made mineral fibres (MMMF) to cause granulomatous lung disease has not been appreciated until now. Recently, we observed the association of sarcoidlike granulomatous reaction and occupational history of glass fibre exposure. We hypothesized that there might be a relationship between MMMF exposure and the development of sarcoidlike granulomas. Therefore, the records of 50 sarcoidosis patients-who visited our outpatient clinic between 1996 and 1999 were reviewed. This revealed that 14 cases recalled a history of exposure to either glass fibres or rock wool, both MMMF fibres. The available obtained tissue specimens (n = 12) were reviewed. In six cases electron microscopy qualitative analysis of small fragments of the tissue revealed among others silica, aluminium and sometimes titanium. A distinct relation between fibre deposits fibre deposits and granulomas was found. These findings indicate that in susceptible people MMMF exposure might be related to a chronic granulomatous disease similar to chronic beryllium disease.  (+info)

Government laboratory worker with lung cancer: comparing risks from beryllium, asbestos, and tobacco smoke. (5/92)

Occupational medicine physicians are frequently asked to establish cancer causation in patients with both workplace and non-workplace exposures. This is especially difficult in cases involving beryllium for which the data on human carcinogenicity are limited and controversial. In this report we present the case of a 73-year-old former technician at a government research facility who was recently diagnosed with lung cancer. The patient is a former smoker who has worked with both beryllium and asbestos. He was referred to the University of California, San Francisco, Occupational and Environmental Medicine Clinic at San Francisco General Hospital for an evaluation of whether past workplace exposures may have contributed to his current disease. The goal of this paper is to provide an example of the use of data-based risk estimates to determine causation in patients with multiple exposures. To do this, we review the current knowledge of lung cancer risks in former smokers and asbestos workers, and evaluate the controversies surrounding the epidemiologic data linking beryllium and cancer. Based on this information, we estimated that the patient's risk of lung cancer from asbestos was less than his risk from tobacco smoke, whereas his risk from beryllium was approximately equal to his risk from smoking. Based on these estimates, the patient's workplace was considered a probable contributing factor to his development of lung cancer.  (+info)

Beryllium presentation to CD4+ T cells underlies disease-susceptibility HLA-DP alleles in chronic beryllium disease. (6/92)

Chronic beryllium disease results from beryllium exposure in the workplace and is characterized by CD4(+) T cell-mediated inflammation in the lung. Susceptibility to this disease is associated with particular HLA-DP alleles. We isolated beryllium-specific T cell lines from the lungs of affected patients. These CD4(+) T cell lines specifically responded to beryllium in culture in the presence of antigen-presenting cells that expressed class II MHC molecules HLA-DR, -DQ, and -DP. The response to beryllium was nearly completely and selectively blocked by mAb to HLA-DP. Additional studies showed that only certain HLA-DP alleles allowed presentation of beryllium. Overall, the DP alleles that presented beryllium to disease-specific T cell lines match those implicated in disease susceptibility, providing a mechanism for this association. Based on amino acid residues shared by these restricting and susceptibility DP alleles, our results provide insight into the residues of the DP beta-chain required for beryllium presentation.  (+info)

HLA-DP allele-specific T cell responses to beryllium account for DP-associated susceptibility to chronic beryllium disease. (7/92)

Occupational exposure to small molecules, such as metals, is frequently associated with hypersensitivity reactions. Chronic beryllium (Be) disease (CBD) is a multisystem granulomatous disease that primarily affects the lung, and occurs in approximately 3% of individuals exposed to this element. Immunogenetic studies have demonstrated a strong association between CBD and possession of alleles of HLA-DP containing glutamic acid (Glu) at position 69 in the HLA-DP beta-chain. T cell clones were raised from three patients with CBD in whom exposure occurred 10 and 30 years previously. Of 25 Be-specific clones that were obtained, all were restricted by HLA-DP alleles with Glu at DP beta69. Furthermore, the proliferative responses of the clones were absolutely dependent upon DP beta Glu(69) in that a single amino acid substitution at this position abolished the response. As befits a disease whose pathogenesis involves a delayed type hypersensitivity response, the large majority of Be-specific clones secreted IFN-gamma (Th1) and little or no IL-4 (Th2) cytokines. This study provides insights into the molecular basis of DP2-associated susceptibility to CBD.  (+info)

IL-4 fails to regulate in vitro beryllium-induced cytokines in berylliosis. (8/92)

Bronchoalveolar lavage (BAL) cells from patients with chronic beryllium disease (CBD) have been used to evaluate the beryllium-specific immune response and potential immunotherapeutics. Beryllium induces interferon-gamma (IFN-gamma), interleukin-2 (IL-2), tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-10 (IL-10) from BAL cells. An antibody to IL-2 and recombinant human (rHu) IL-10 is able to partially suppress the beryllium-stimulated immune response. To obtain BAL cells, bronchoscopy is required, providing risk to the patient and a limited number of cells to study the immune response. As a result, the objectives of the study were to determine 1) whether CBD peripheral blood mononuclear cells (PBMNs) stimulated with beryllium would produce a similar cytokine pattern as BAL cells, and 2) whether this response could be modulated by interleukin-4 (IL-4), an immunomodulatory cytokine. CBD and normal individuals' PBMN and BAL cells were stimulated with and without beryllium sulfate. To modulate this antigen-stimulated response, we added rHu IL-4 to the unstimulated and beryllium-stimulated cells. IFN-gamma, IL-2, TNF-alpha, IL-6 and IL-10 cytokine concentrations were determined from cell supernatants by enzyme-linked immunosorbent assays (ELISA), while IL-4 messenger ribonucleic acid (mRNA) was assessed using polymerase chain reaction (PCR). Beryllium did not stimulate any of these cytokines from normal PBMNs. Increasing levels of IL-6 and TNF-alpha were produced constituitively by CBD PBMNs over time. Compared to the unstimulated CBD PBMNs, beryllium stimulated significant IFN-gamma, TNF-alpha, IL-2, IL-6 and IL-10 production. This response was similar to that stimulated from CBD BAL cells, although of a much lower magnitude. Low levels of IL-4 mRNA were found in CBD and control PBMNs, which were not increased with beryllium stimulation. The beryllium-stimulated cytokine levels were not decreased by the addition of IL-4. IL-4 was unable to downregulate any of these beryllium-stimulated cytokines from CBD BAL cells or increase IL-4 mRNA from either CBD PBMN or BAL cells, and thus is an unlikely immunomodulatory agent in CBD. From the data, it was concluded that chronic beryllium disease peripheral blood mononuclear cells provide a model to study the beryllium-stimulated immune response. Interleukin-4's inability to downregulate any of the beryllium-stimulated cytokines makes it an unlikely therapeutic candidate in chronic beryllium disease.  (+info)

Unfortunately no cure has been found yet; but treatment and management of chronic beryllium disease can slow down the progression of this disease.
The human leukocyte antigen (HLA) complex is a series of genes located on chromosome 6 that are important in normal immune function. Susceptibility to chronic beryllium disease, a granulomatous lung disease that appears in workers exposed to beryllium, is modified by genetic variants of the HLA-DP subregion. Evaluation of HLA-DPB1 sequence motifs in current and former beryllium workers implicated
Information on the respiratory infections beryllium sensitization and chronic beryllium disease (CBD) and their symptoms, causes, diagnosis, and treatment.
Chronic beryllium disease (CBD) can be caused when one is exposed to fumes, dust, powder containing beryllium and has an allergic reaction. Most people ...
Inhalation of beryllium (Be) has been associated with 2 pulmonary syndromes, which are an acute chemical pneumonitis and a granulomatous lung disease known as chronic beryllium disease (CBD), or berylliosis. In acute beryllium disease, the metal acts as a direct chemical irritant, causing a nonspecific inflammatory reaction (acute chemical p...
Inhalation of beryllium (Be) has been associated with 2 pulmonary syndromes, which are an acute chemical pneumonitis and a granulomatous lung disease known as chronic beryllium disease (CBD), or berylliosis. In acute beryllium disease, the metal acts as a direct chemical irritant, causing a nonspecific inflammatory reaction (acute chemical p...
Bronchoalveolar lavage (BAL) cells from patients with chronic beryllium disease (CBD) have been used to evaluate the beryllium-specific immune response and potential immunotherapeutics. Beryllium induces interferon-y (IFN-y), interleukin-2 (IL-2), tumour necrosis factor-a (TNF-a), interleukin-6 (IL-6) and interleukin-10 (IL-10) from BAL cells. An antibody to IL-2 and recombinant human (rHu) IL-10
Sigma-Aldrich offers abstracts and full-text articles by [Gina M Clayton, Yang Wang, Frances Crawford, Andrey Novikov, Brian T Wimberly, Jeffrey S Kieft, Michael T Falta, Natalie A Bowerman, Philippa Marrack, Andrew P Fontenot, Shaodong Dai, John W Kappler].
Learn more about Berylliosis at Reston Hospital Center DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
Learn more about Berylliosis at Reston Hospital Center DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
To study the immunologic function of bursin, we analyzed the effects of anti-bursin monoclonal antibody (mAb) on the immunosuppression in ducks (Cherry Valley duck) by injecting various doses of the anti-bursin mAb into 13-d duck embryos. After hatch, cell-mediated immune activity and humoral responses were studied using lymphocyte proliferation test, tube agglutination test, and indirect enzyme-linked immuno-sorbent assay to detect anti-Escherichia coli antibodies and antibodies to Riemerella anatipester, respectively. Simultaneously, relative weights (BW-adjusted) of bursa of Fabricius (BF), spleen, and thymus were determined. Additionally, the morphology of BF, spleen, and thymus was examined at various ages using conventional histology. Follicle morphology of BF was analyzed by image analysis. The results indicated that anti-bursin mAb markedly decreased duck lymphocyte proliferation, the antibody-producing ability to bacteria, as well as the relative BF weight. Moreover, the anti-bursin mAb ...
Some new tests have been introduced, unfortunately there are no published studies demonstating their validity. One test is called an immune tolerance test. It measures T cell proliferation after exposure to select Lyme antigens. There exist very few studies regarding such lymphocyte proliferation tests for diagnosing Lyme. Oddly, the background paper published by the manufacturer, describing the underpinnings of this technology, cites an old Wormser study in the foot notes. The Wormser study using somewhat different methods concluded the test was insensitive but specific ...
One of the first identified age-associated functional changes in immune response was decreased DTH responses. In fact the DTH response is an example of a T.h response mediated primarily through th-1-type cytokines although many events are required before proliferation, assessment of lymphocyte proliferation often has been used as an indicator of ...
Beryllium can be harmful if it is inhaled, depending on how much beryllium one inhales and how long the exposure lasts. "If beryllium air levels are high enough (greater than 1000 µg/m3), an acute condition can result. This condition resembles pneumonia and is called acute beryllium disease."[6]. Individuals who are sensitive to beryllium can develop an inflammatory reaction in the respiratory system. This is called chronic beryllium disease (CBD), and can occur many years after exposure to higher than normal levels of beryllium (greater than 0.5 µg/m3). "This disease can make you feel weak and tired, and can cause difficulty in breathing. It can also result in anorexia, weight loss, and may also lead to right side heart enlargement and heart disease in advanced cases. Some people who are sensitized to beryllium may not have any symptoms. The general population is unlikely to develop acute or chronic beryllium disease because ambient air levels of beryllium are normally very low ...
DOE describes Hanford as the worlds largest environmental remediation project. In addition to the remnants of nine plutonium reactors, Hanford holds 4.6 million pounds of irradiated uranium fuel rods and 53 million gallons of radioactive waste buried in underground tanks, some of which have leaked into the groundwater and are moving toward the Columbia River. Radiation has long been the dean of hazards at nuclear cleanup sites, but in April 2009, the Hanford Advisory Board, a group chartered by DOE that includes current and former Hanford workers, medical specialists, environmental and worker-safety advocates, and local government officials, wrote a letter advising the department that from a worker safety perspective ... beryllium currently rates as a greater hazard than radiation. The letter included a disquieting calculation: Studies have found that between 2 percent and 6 percent of people exposed to beryllium will become sensitized or develop CBD. At the time of the letter, 115 of 4,583 ...
Chronic Beryllium Disease (CBD) primarily affects the lungs. CBD may occur among dental laboratory technicians when they inhale dust containing beryllium when working on items such as dental crowns, bridges, and partial denture frameworks made from dental alloys containing beryllium. CBD may develop within months after initial exposure to beryllium or may have a very slow onset and not develop until years after exposure to beryllium has occurred. The amount or length of exposure to beryllium necessary to cause a specific individual to develop CBD is not known, but recent information suggests that even short exposures (weeks or months) to levels of beryllium below OSHAs PEL of 2 μg/m3 averaged over an 8-hour day may lead to CBD in some workers (Source: OSHA). ...
People working or living near beryllium industries have the greatest potential for exposure to beryllium. Lung damage has been observed in people exposed to high levels of beryllium in the air. About 1-15% of all people occupationally-exposed to beryllium in air become sensitive to beryllium and may develop chronic beryllium disease (CBD), an irreversible and sometimes fatal scarring of the lungs. CBD may be completely asymptomatic or begin with coughing, chest pain, shortness of breath, weakness, and/or fatigue. Beryllium has been found in at least 535 of the 1,613 National Priorities List sites identified by the Environmental Protection Agency (EPA).
Summary of lung function and beryllium exposure of case 2. (A) Results of pulmonary function tests before, during, and after acute work-related illness. (B) TWA
The Occupational Safety and Health Administration (OSHA) recently issued a final rule modifying a 40-year-old standard pertaining to exposure to beryllium and beryllium compounds. It contains new requirements for general, construction and shipyard industries. Similar to the recent changes to crystalline silica regulations, the rule is anticipated to save lives and protect workers from serious illnesses. Beryllium and beryllium compounds are lightweight, extremely strong metals used in the aerospace, electrical, energy, telecommunications, medical and defense fields. Beryllium-copper alloys are frequently used for their electrical and thermal conductivity as well as their hardness. Beryllium oxide is used as a component in ceramics for electronics and other electrical equipment because of its heat conductivity, high strength, hardness and electrical insulating properties. Unfortunately, beryllium is highly toxic when inhaled. Inhaling airborne beryllium can result in a lung condition known as ...
Silver, K., Kukulka, G., Gorniewicz, J., and Rayman, K., Genetic susceptibility testing for beryllium: Worker Knowledge, beliefs and attitudes, Amer. J. of Industrial Med., 54(7): 521-32 (July 2011) Dobbin, D., Turpin, R.D., Silver, K. et al, Hazardous Waste. Chapter 10. In: Occupational Health: Recognizing and Preventing Work-Related Disease and Injury, 5 th edition. Levy, B.S., Wegman, D.H., Baron, S., and Sokas, R. Eds. (New York: Oxford University Press, 2011), pp. Silver, K. and Clapp, R., Environmental surveillance at Los Alamos: an independent reassessment of historical data, Risk Analysis, 26(4): 893-906 (August 2006) Silver, K. and Sharp, R., Ethical considerations in testing workers for the -Glu69 marker of genetic susceptibility to chronic beryllium disease, 48(4): 434-443 (April 2006) Silver, K., The Energy Employees Occupational Illness Compensation Program Act. AAOHN Journal, 53(6): 267-77 (June 2005) SELECTED PRESENTATIONS Green, C.C. and Silver, K., Analysis of the Energy Claims ...
NOTICE OF FINAL DECISION This is the decision of the Final Adjudication Branch (FAB) concerning the above-noted claim for benefits under the Energy Employees Occupational Illness Compensation Program Act of 2000, as amended (EEOICPA), 42 U.S.C. 7384 et seq. For the reasons stated below, this claim for survivor benefits under Part B of EEOICPA based on chronic beryllium disease (CBD) is denied.. STATEMENT OF THE CASE. On September 13, 2010, the claimant filed a Form EE-2 claiming survivor benefits as the alleged surviving spouse of [Employee], and alleged that the employee had contracted bladder cancer, colon cancer, chronic obstructive pulmonary disease (COPD), chronic renal failure, coronary artery disease, and CBD due to his work. On July 1, 2011, FAB issued a final decision accepting this claim under Part E of EEOICPA as the surviving spouse of [Employee]. In that decision, FAB found that [Employee] was a covered Department of Energy (DOE) contractor employee at the Portsmouth Gaseous ...
Beryllium nitrate, also known as beryllium dinitrate, is an ionic beryllium salt of nitric acid with the chemical formula Be(NO3)2. Each formula unit is composed of one Be2+ cation and two NO3− anions. Beryllium nitrate is a toxic chemical, like all other beryllium compounds. It is also an irritant in small doses. When burned, it gives off irritating or toxic fumes. However, when massive short-term exposure occurs, acute pneumonitis can set in, but symptoms do not manifest themselves for 3 days. Beryllium nitrate can be prepared by reacting beryllium hydroxide in nitric acid. s "NIOSH Pocket Guide to Chemical Hazards #0054". National Institute for Occupational Safety and Health (NIOSH). "Beryllium Nitrate (ICSC)". IPCS INCHEM. Retrieved 13 September 2010. Walsh, Kenneth (2009). Beryllium chemistry and processing. ASM International. pp. 121-122. ISBN 978-0-87170-721-5. Retrieved 3 January 2011 ...
Los Alamos National Laboratory announced Wednesday it is notifying nearly 2,000 current and former employees and visitors that they may have been exposed to beryllium in the lab and may be at risk of disease.
Synopsis of Global Beryllium Copper Market 2017 Research Report. The report about Global Beryllium Copper Market 2017 constitutes of pervasive fundamental research along with a structured analysis of qualitative as well as quantitative facet by assorted industry connoisseurs and main opinion leaders to gain a profound insight of the market and industry performance.. The report "Global Beryllium Copper Market 2017" gives a clear sight of the present-day market scenario which comprises of historical and estimated forthcoming market size on the basis of technological growth, value and volume, prominent economic and governing elements in the market.. Do Inquiry Before Accessing Global Beryllium Copper Market 2017 Report at: https://market.biz/report/global-beryllium-copper-market-icrw/83388/#inquiry. The report "Global Beryllium Copper Market 2017" further imparts detail information about approaches and tactics used by elite key players in the Beryllium Copper industry. It also gives an extensive ...
To investigate the effects of short-term exposure of beryllium on the human immune system, the proportion of T-lymphocytes such as CD3+, CD4+, CD8+, CD95, and NK cells, andthe proportion of B cells and TNFα level in peripheral blood and immunoglobulins in the serum of 43 exposed workers and 34 healthy control subjects were studied. External exposure to beryllium was measured by atomic absorption spectrometer as recommended by the NIOSH analytical method 7300. T lymphocyte subpopulation analysis was carried out with flow cytometer. The working duration of exposed workers was less than 3 months and the mean ambient beryllium level was 3.4 μg/m(3), 112.3 μg/m(3), and 2.3 μg/m(3) in molding (furnace), deforming (grinding), and sorting processes, respectively (cited from Kim et al., 2008). However, ambient beryllium level after process change was non-detectable (| 0.1 μg/m(3)). The number of T lymphocytes and the amount of immunoglobulins in the beryllium-exposed workers and control subjects were not
PITTSBURGH, June 23, 2017 - The United Steelworkers (USW) today blasted the Administrations proposal to cancel important protections for shipyard and construction workers exposed to beryllium. Under the proposal OSHA released this morning, employers would no longer have to measure beryllium levels in the workplace or provide medical testing to workers at risk of fatal lung disease. In addition, workers would not have the right to wear protective clothing or to shower at the end of the work shift, making it possible for beryllium to be taken home and exposed to spouses and children. Beryllium is a highly useful metal, but it can cause a crippling and sometimes fatal disease that ultimately robs sufferers of the ability to breathe. OSHA issued new beryllium standards in January covering workers in all industries. Todays proposal eliminates most of the provisions covering the maritime and construction industries. The USW has members in both industries, including workers at the Newport News ...
Federal Register Volume 84, Number 189 (Monday, September 30, 2019)] [Rules and Regulations] [Pages 51377-51400] From the Federal Register Online via the Government Publishing Office [www.gpo.gov] [FR Doc No: 2019-21037] ======================================================================= ----------------------------------------------------------------------- DEPARTMENT OF LABOR Occupational Safety and Health Administration 29 CFR Parts 1915 and 1926 [Docket No. OSHA-H005C-2006-0870] RIN 1218-AD21 Occupational Exposure to Beryllium and Beryllium Compounds in Construction and Shipyard Sectors AGENCY: Occupational Safety and Health Administration (OSHA), Labor. ACTION: Final rule. ----------------------------------------------------------------------- SUMMARY: OSHA is finalizing the proposed rule on occupational exposure to beryllium and beryllium compounds in construction and shipyards by delaying the compliance deadlines for nearly all provisions of the standards to September 30, 2020. The ...
The first problem was one I was handed sort of on a silver platter when I went to the Mass General Hospital in Boston. I was in the department of medicine at Harvard was located at Mass General Hospital in the Huntington laboratories. The Chief of the laboratory, Dr. Joseph Aub who is a world known physician told me about beryllium and the fact that beryllium was causing very severe illness in women who were working in factories to remove the phosphors from inside fluorescent lamp bulbs. They wanted to retrieve the phosphors. One of the key ingredients in the phosphor was beryllium, the metal beryllium. Its the lightest metal with an atomic weight of 9.I think thats right. Its long time ago.. It caused some interesting effects that the scientists have studied, mainly if injected into rabbits it caused bad bone tumors. If it was injected into-well, these women who were scrubbing out the tubes died, almost all of them of severe pulmonary disease as a result of breathing in the beryllium. So he ...
Press Release issued Jul 21, 2017: The purpose of Global Beryllium Oxide (BeO) Powder Market report is to provide the newest industry data and Beryllium Oxide (BeO) Powder industry future trends, allowing consumers to identify the Beryllium Oxide (BeO) Powder market Application, Type, Manufacturers and Regions, Beryllium Oxide (BeO) Powder market Forecast up to 2022.
Ending decades of denial and inaction, the federal government has issued a tough new exposure standard for people who work with the toxic metal beryllium.
The question of whether the federal government has been at fault for the deaths and injuries of American beryllium workers will be the subject of a formal investigation by the General Accounting Office, the investigative arm of Congress.. The order to GAO to study the hazards of beryllium, a metal used by the Department of Defense and the Department of Energy because of its light weight and strength in the manufacture of weapons, came from a bipartisan group of eight members of Congress.. Led by Sen. Mike DeWine (R., O.), the ad hoc coalition includes Sens. John McCain (R., Ariz.) and Robert Bennett (R., Utah); and Reps. Marcy Kaptur (D., Toledo), Chris Shays (R., Conn.), Jim Kolbe (R., Ariz.), Tim Holden (D., Pa.), and Paul Kanjorski (D., Pa.).. Mr. DeWine began the call for a GAO investigation in April and has since been organizing and collecting support from colleagues. He said his actions were sparked by a series in The Blade that detailed a decades-long pattern of the U.S. government ...
On January 9, 2017, OSHA published a final rule amending its standards for occupational exposure to beryllium and beryllium compounds. United States Employment and HR Arnold & Porter 26 Jan 2017
With an atomic number of 4, beryllium has four electrons: two electron shells surround the atoms nucleus and two electrons in each shell. Beryllium is a rigid metal with an atomic mass of 9.0122. It...
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The extraction of beryllium has been carried out in the presence of butyric acid. Of the solvents tried, viz., ether, benzene, chloroform, amyl acetate, ethyl acetate and carbon tetrachloride, chloroform is found to be the best, ethyl acetate being the next. 30.7 mg of BeO in solution as chloride is raised to a pH of 9.3 to 9.5 to which 10-15 ml of butyric acid is added. Four extractions with chloroform extract 99% of beryllium. ...
The company plans to utilize this facility to manufacture small quantities of the listed controlled substances in bulk and to conduct analytical testing in support of the companys primary manufacturing facility in West Deptford, New Jersey. The controlled substances manufactured in bulk at this facility will be distributed to the companys customers.. No comments or objections have been received. DEA has considered the factors in 21 U.S.C. 823(a) and determined that the registration of Johnson Matthey Pharmaceutical Materials, Inc. to manufacture the listed basic classes of controlled substances is consistent with the public interest at this time. DEA has investigated Johnson Matthey Pharmaceutical Materials, Inc. to ensure that the companys registration is consistent with the public interest. The investigation has included inspection and testing of the companys physical security systems, verification of the companys compliance with state and local laws, and a review of the companys ...
The early rapid proliferation of epithelium is a pre-requisite for the rapid healing of wound surface of epithelium. In the present tests, the epithelial cells used for identifying test materials are taken from normal human skin, and the cells are cultured and grow in media containing the silicon and calcium microparticles of the present invention prepared according to the process of the Example 2. The specific combinations of chemical ingredients are pre-added in to the cell culture media used in the present tests at the concentrations as depicted in the Table of Fig. 3. One group serves as a control. Experimental groups with the test materials are compared to said control group to determine the induction effect of the test materials on the growth of cells. During the culture procedure, the media are replaced with fresh media having the same specific compositions every four days. Cell proliferation tests are conducted on the 12th and 20th day by counting the total number of cells grown in media ...
Products by element - Beryllium, include metal, alloy, compounds and fabrication products like sputtering targets etc. from ALB Materials Inc. - Page Total 1 Page 5 Records
QUEBEC CITY, QUEBEC--(Marketwire - March 31, 2010) - Nemaska Exploration Inc. («Nemaska» or «the Corporation») (TSX VENTURE:NMX) is pleased to announce that the most recent results from its current drill program on its lithium/beryllium (Whabouchi project, 100 % owned) continues to prove the high-grade, impressive width and continuity of the mineralized zone. Nemaska has received an additional 1,057 results from 15 holes. The latest results include 52.3 m at 1.85% Li2O, 165 ppm Be and 1579 ppm Rb and 22.8 m at 1.91 % Li2O, 130 ppm Be and 1503 ppm Rb.. «I am very pleased with the grade and width of our drill results to date which favourably compare to any other spodumene bearing pegmatite project currently in development around the world», commented Mr. Guy Bourassa, President and CEO. «The current drilling should be completed by mid-April, allowing us to finalize the resource calculation presently underway. I am also pleased to see that the Be and Rb grades remain constant throughout the ...
The report on Beryllium Oxide (BeO) Powder Market offers a complete analysis of the market. This was achieved with the help of the chronological data that was collected, the exhaustive qualitative insights, and the statistical data of the market. Thorough studies and researches were conducted and reliable methodologies were used to verify the data that was collected. Industrial experts were consulted and their opinions were taken into consideration while making studies of the market.. Primary researches were made which include surveys, opinions of seasoned analysts, and interviews. For collecting and verifying the data, the use of secondary researches was also made which includes reputable paid sources, industry body databases, entails, and trade journals. Both qualitative and quantitative assessments were made across different industrial aspects and market verticals.. Analysis of different trends that is prevailing in the market was made. The segmentation of the market was included. Studies of ...
Berylliums role in the SSGCID will include gene construction and expression testing in bacterial and cell-free systems, large-scale protein production and purification; crystallization screening and production, pre-screening of crystals before they are sent for data collection at the synchrotron beam-lines, and structure determination using the resulting data.
To see a rotating video of (almost) any of the samples of Beryllium from The Elements, click it below. Links will open in a new window ...
Beryllium 2007 Mustang Saleen S281 Extreme coupe, front right view. This photo is available in two wallpaper sizes; 800-600 wallpaper and 1024-768 wallpaper.
The heat treatment of corundum involving lattice diffusion of beryllium (Be) at temperatures over 1800°C has become a major issue in the gem trade.
Article Wire manufacturing facility - Case Study. Bench-Scale Stormwater Treatment StudyA large wire manufacturer in Washington State asked Dungeness Environmental to perform a treatability study on their stormwater run-off. The run-off requires reme...
This is the outline for this chapter. Please contribute to it by providing the overview and introduction to this group of diseases.. ...
Results The DPβE69 residue regardless of zygosity, but particularly if present on non-*0201 alleles, was of primary importance for the development of CBD and BeS, while other negatively charged residues DPβDE55, 56 and DPβDE84, 85 incrementally increased, although not independently, the risk. The DPβE69 positive alleles with charge −7 or −9 were associated with both CBD and BeS. The polymorphic residues DPβE69, DPβDE55, 56 and DPβDE84, 85 were responsible for the −9 charge and the first two residues for the −7 charge. ...
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UNITED STATES DISTRICT COURT FOR THE SOUTHERN DISTRICT OF NEW YORK,June 25, 1969,The opinion of the court was delivered by: COOPER,Securities and Exchange Commission Plaintiff v. American Beryllium & Oil Corporation Defendants. [6] Cooper, District Judge.
Beryllium Nitride Be3N2 bulk & research qty manufacturer. Properties, SDS, Applications, Price. Free samples program. Term contracts & credit cards/PayPal accepted.
A $7m contract for the supply of beryllium metal has been awarded for the Joint European Torus (JET), the largest experimental nuclear fusion reactor in the world, which is to be recommissioned to carry out tests for the ITER project.
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In seven patients with chronic beryllium disease (Be) the Be lymphocyte transformation test was positive in 100%, independent of steroid therapy, and was reproducible. The Be macrophage migration inhibition test was only positive in four of seven patients (57%) not on steroids, and was not reproducible. In 72 potentially exposed healthy beryllium workers the lymphocyte transformation test was negative in all subjects. The macrophage test was positive in four of 78 and again the results were not reproducible. The workers with positive results showed no differences in age, type or duration of employment from those with negative results and showed no evidence of disease. In addition, the macrophage test was positive in two of 45 non-exposed control subjects. We also confirmed the above advantages of the lymphocyte transformation technique by using tuberculin antigen (PPD). The PPD lymphocyte transformation test gave positive results in approximately 60% of healthy beryllium workers, but the PPD ...
This is the decision of the Final Adjudication Branch concerning your claim for compensation under Part B of the Energy Employees Occupational Illness Compensation Program Act of 2000, as amended, 42 U.S.C. 7384 et seq. (EEOICPA or the Act). This decision affirms the recommended acceptance issued on November 30, 2004.. STATEMENT OF THE CASE. On May 28, 2004, you filed a claim for survivor benefits, as the widow of [Employee], Form EE-2, under Part B of the EEOICPA. You identified breathing problems and chronic beryllium disease (CBD) as the claimed conditions. You also filed a Form EE-3 indicating that your husband was employed by F.H. McGraw at the Paducah Gaseous Diffusion Plant in Paducah, Kentucky from 1951 to I don t remember. The Department of Energy (DOE) was unable to verify employment, however, they did confirm that F.H. McGraw held a number of contracts, during this time, at the Paducah Site. You submitted Social Security records indicating that your husband was employed by F.H. McGraw ...
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Sterzl I, Prochazkova J, Hrda P, Matucha P, Bartova J, Stejskal V.. Institute of Immunology and Microbiology, 1st Medical Faculty, Charles University, General Faculty Hospital, Prague, Czech Republic. zc.inuc.1fl,retsi#zc.inuc.1fl,retsi. OBJECTIVES: The impact of dental amalgam removal on the levels of anti-thyroid peroxidase (anti-TPO) and anti-thyroglobulin (anti-Tg) antibodies was studied in patients with autoimmune thyroiditis (AT) with and without mercury allergy. METHODS: Thirty-nine patients with AT were tested by an optimized lymphocyte proliferation test MELISA for allergy (hypersensitivity) to inorganic mercury. Patients were divided into two groups: Group I (n = 12) with no hypersensitivity to mercury and Group II (n = 27) with hypersensitivity to mercury. Amalgam fillings were removed from the oral cavities of 15 patients with hypersensitivity to mercury (Group IIA) and left in place in the remaining 12 patients (Group IIB). The laboratory markers of AT, anti-TPO and anti-Tg ...
We report the formation of beryllium doped plasma polymerized coatings derived from a helical resonator deposition apparatus, using diethylberyllium as the organometaric source. These coatings had an appearance not unlike plain plasma polymer and were relatively stable to ambient exposure. The coatings were characterized by Inductively Coupled Plasma Mass Spectrometry and X-Ray Photoelectron Spectroscopy. Coating rates approaching 0.7 {mu}m hr{sup {minus}1} were obtained with a beryllium-to-carbon ratio of 1:1.3. There is also a significant oxygen presence in the coating as well which is attributed to oxidation upon exposure of the coating to air. The XPS data show only one peak for beryllium with the preponderance of the XPS data suggesting that the beryllium exists as BeO. Diethylberyllium was found to be inadequate as a source for beryllium doped plasma polymer, due to thermal decomposition and low vapor recovery rates.
Analytical techniques have been developed for the determination of carbon in high-purity beryllium. The method, a modification of the combustion-conductometric technique, permits an increase in the sample size of about four times, thereby achieving a fourfold reduction in the lower limit of useful analytical results. Sensitivity has been demonstrated for carbon contents as low as 25 ppm. The accuracy of a solution distillation technique for determination of nitrogen in high-purity beryllium has been established. A modified micro-Kjeldahl still was employed. Nitrogen contents less than 10 ppm can be accurately determined. Three batches of beryllium weighing roughly 5 pounds each have been prepared. Each batch was attritioned, sized and blended to provide a homogeneous material for analytical standards. These standards, in the form of coarse chips, have the following carbon and nitrogen contents for the 3 standards in parts per million, respectively: carbon, 25, 101, and 120 and nitrogen, 11, 55,
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Beryllium coatings with varying thicknesses and columnar grain sizes were deposited by low temperature magnetron sputtering and wet chemically etched to enhance diffuse absorption of light. After etching these coatings exhibited a matte black surface finish and low specular reflectance (below 2%) in the IR up to a critical wavelength dependent upon the original grain size of the coating. Extremely thick coatings (350 µm) with original grain sizes of 10 to 12 µm were produced which exhibited specular reflectances below 0.5% up to 50 µm wavelength and a Lambertian BRDF at 10.6 µm averaging 4.3x10-3 ster-1. Scanning electron micrographs are presented for etched and unetched beryllium coatings which showed the etching process produces roughness and porosity over several size scales simultaneously with the maximum size scale limited by the initial coating grain size and thickness. This technique for producing diffuse absorbing baffle materials has great versatility in choice of coating material and
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Chronic granulomatous disorder, also known as Bridges-Good syndrome, is a diverse group of hereditary diseases in which certain cells of the immune system have difficulty forming the reactive oxygen compounds used to kill certain ingested pathogens.
LORAIN -- A city councilwoman who fought for more than a year to ban a controversial substance within city limits said she now can rest easier. A representative from Brush Wellman Inc. signed a voluntary agreement with the city on Wednesday, stating that the companys bronze engineering plant in the Lorain would not produce, store or manufacture beryllium.. Beryllium, a compound used as an alloy with other metals in the defense, electronics and automotive industry, has been known to cause chronic and fatal lung disease if its dust is inhaled during its manufacturing process.. State and federal laws regulate the production of beryllium. But the compound earned a reputation locally at the former Brush Beryllium plant on West First Street in Lorain during the 1930s and 40s. Several workers there and residents living near the plant at the time became ill and died, according to a study completed in 1944.. City Councilwoman Kathy Tavenner, D-at large, had fought for the past 15 months to get Council ...
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This invention recognizes the hazards of beryllium and beryllium oxide in automotive applications and offers alternative material solutions. In particular, commercial electrochromic mirrors use beryllium comprising alloys for busbars and may also use beryllium oxide for the electronics used to power and control these mirrors. Further, this can be combined by reducing other known hazards such as mercury, cadmium, lead and antimony compounds.
Pittsburgh Post-Gazette editorial urging exposure standards for all workers who could be exposed to beryllium in their jobs. (December 15, 1999) ...
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Quantum molecular dynamics study of expanded beryllium: evolution from warm dense matter to atomic fluid.: By performing quantum molecular dynamics (QMD) simula
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Beryllium nitride, also called triberyllium nitride, is the chemical compound with the molecular formula Be3N2 and a molar mass is 55.06 grams per mole. It is a yellow-white powder at standard...
Page contains details about beryllium zinc oxide nanorods . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
Semiconductor manufacturing facilities employ a number of hazardous gases in their production processes. Whenever these gases are stored, distributed or used in manufacturing processes, there exists the potential for a hazardous condition. The primary hazards associated with these gases include fire, explosion, and contamination resulting in product loss or unscheduled preventative maintenance. These gases must be continuously monitored to ensure the health and safety of employees, to protect property, as well as to maintain regulatory compliance.
Medrad, a provider of medical devices and services for imagingprocedures, has opened a new manufacturing facility that will producedisposable components for its vascular injection systems.
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Based on information from the Department of Energy and Department of Labor, most of the locations in Ohio that may have workers with beryllium sensitivity or CBD are located in Southern Ohio (Piketon Gaseous Diffusion Facility) or facilities operated by Brush Wellman near Cleveland and Sandusky. It is possible that other vendors or contractors to these facilities may have employees who develop these conditions. Regardless, these claims most likely will not be widespread and there will probably be limited interest in examiners to learn about the conditions. Only examiners who may evaluate these individuals routinely will be familiar with process of obtaining blood and sending for the BeLPT. It is probably not reasonable to require or allow examiners to perform bronchoalveolar lavage or lung biopsy since these are independent medical evaluations and invasive procedures are typically not performed. HRCT scan is probably also not beneficial unless requested by the examiner when absolutely necessary ...
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May cause inflammation of lungs, nose, throat and the mucous membrane of both the trachea and bronchi, hyperemia, edema, hemorrhage with mild edema of the brain, inflammation of the liver, focal hemorrhage of the spleen, granulomatous, crippling, incurable lung disease, pneumonitis, pulmonary dysfunction, heart enlargement and congestive heart failure, cyanosis, enlargement of liver and spleen, digital clubbing, formation of kidney stones, malignant tumors, cellular infiltration, interstices of various organs and tissues and calcific inclusions in cells and tissues ...
The OLD SEAL Team knife (made by Buck Knives) had an alloy of beryllium and titanium, thus it had no magnetic properties, but guys kept getting tumors in their hands from sharpening the knife and getting tiny shards of metal into their skin. Even that didnt stop the military from continuing the use of the knife until 1991 when the great knife-off at NAVSPECWARGRUONE when the MPK titanium knife (made by Mission Knives) won the competition - beryllium free.. ReplyDelete ...
Move victim to fresh air. Apply artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult ...
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Diffusion treatment is a treatment used to alter the color of a gemstone (mostly for sapphires). Smaller atoms (usually beryllium) enter the lattice of the crystal and penetrate it deeply. This fairly recent treatment (1990s) is in some cases only detectable by the use of sophisticated laboratory techniques.. ...
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Uninterrupted and rapid product supply of cell culture media is critical, so Irvine Scientific is continually improving to meet the challenges our customers face. In order to address these concerns, Irvine Scientific has state-of-the-art powder manufacturing facilities located in both Santa Ana, CA and Tokyo, Japan. Both facilities provide complete redundancy in milling technology, raw materials, processes, and quality systems.. ...
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Beryllium copper springs are cold rolled and may be mill hardened before fabrication. Good corrosion resistance and electrical conductivity.
beryllium (Be): Be chemical element, the lightest member of the alkaline-earth metals of Group 2 (IIa) of the periodic table, used in metallurgy as a hardening agent and in many outer space and...
United States Beryllium Aluminum Alloy Industry 2016 Market Research Report is a new market research publication announced by Reportstack. This report is a professional and in-depth study on the current state of the Beryllium Aluminum Alloy industry.. The report provides a basic overview of the industry including definitions, classifications, applications and industry chain structure. The Beryllium Aluminum Alloy market analysis is provided for the United States markets including development trends, competitive landscape analysis, and key regions development status.. Development policies and plans are discussed as well as manufacturing processes and Bill of Materials cost structures are also analyzed. This report also states import/export consumption, supply and demand Figures, cost, price, revenue and gross margins.. To access full report with TOC, please visit United States Beryllium Aluminum Alloy Industry 2016 Market Research Report. The report focuses on United States major leading industry ...
The first part of this book deals with the methods used to define and study occupational respiratory diseases and includes an assessment of chest x-rays, pulmonary function data, and lung impairment. The second part of the book deals with specific classes of respiratory diseases, their definition, epidemiology, diagnosis and treatment. Specific topics in the second section are pneumoconioses (silicosis, acute silicosis, silicate pneumoconiosis, asbestosis, coal workers pneumoconiosis and exposure to other carbonaceous dusts, beryllium disease, pulmonary reactions to miscellaneous mineral dusts as well as man made mineral fibers and miscellaneous pneumoconioses), occupational asthma and rhinitis, hypersensitivity, chronic airways obstruction (chronic bronchitis and emphysema), byssinosis, effects of inhaled toxic agents (acute and chronic respiratory effects, and acute systemic effects of inhaled occupational agents), neoplasms (epidemiology of occupationally induced lung cancer, pathology of ...
I have seen ZnO in silicone grease, Indium washers, BeO washers, plain silicone grease, and ZnO in petroleum grease, but NEVER BeO grease. Some space hardware does, however make use of beryllium metal (it is light and a good thermal conductor) as a backplane material. It was used in Motorolas Iridium program. Scott ----- Original Message ----- From: J. Forster ,jfor at QUIK.COM, To: ,BOATANCHORS at LISTSERV.TEMPE.GOV, Sent: Wednesday, November 03, 2004 9:44 PM Subject: Re: Thermal Grease , It is possible that at one time BeO was used in grease, but Ive never , seen it and , Ive been using the stuff since 1963. I very much doubt its in commercial , use , anymore. In the late 60s, I was using BeO washers on TO-3 transistors. , , FWIW, , -John , , , Garey Barrell wrote: , ,, Wes - ,, ,, That makes me feel better. I thought I remembered beryllium oxide ,, grease. NASA certainly was well above us mere mortals! At least in ,, the 60s when I was there... ,, ,, Garey - K4OAH ,, ,, W. Kranitz ...
By the 1996, the US Department of Energy identified more than 50 cases of chronic berylliosis among nuclear industry employees ... Machining the tamper shells produces beryllium and beryllium oxide dust; its inhalation can cause berylliosis. ...
She discovered that many of the workers contracted berylliosis. Berylliosis is caused by the inhalation of dust or fumes ...
Many conditions can cause Schaumann bodies, including: Sarcoidosis, Hypersensitivity pneumonitis, and Berylliosis. uncommonly, ...
Single or chronic exposure can lead to berylliosis, an incurable lung condition. In addition, beryllia is listed as a confirmed ...
Chronic berylliosis is a pulmonary and systemic granulomatous disease caused by exposure to beryllium. Between 1% - 15% of ... called chronic beryllium disease or berylliosis. The body's immune system recognises the beryllium as foreign particles and ...
One method of classification is as follows: Inhaled substances Inorganic Silicosis Asbestosis Berylliosis printing workers (eg ... berylliosis, lymphangitic carcinomatosis, lymphoma, lymphocytic interstitial pneumonia For some types of chILD and few forms ... berylliosis Peripheral predominance Idiopathic pulmonary fibrosis, chronic eosinophilic pneumonia, cryptogenic organizing ...
... may be used to distinguish sarcoidosis from conditions with otherwise indistinguishable symptoms such as berylliosis ...
... and is distinct from berylliosis (also called chronic beryllium disease). After occupational safety procedures were put into ... place following the realization that the metal caused berylliosis around 1950, acute beryllium poisoning became extremely rare ...
... returned there in 1978 as a fellow and then a senior fellow until his death from an almost forty-year struggle with berylliosis ...
He died at age 39 in Palo Alto, California of berylliosis and fibrosis of the lungs, caused by inhaling the beryllium used in ...
Conglomerate masses may also occur in other pneumoconioses, such as talcosis, berylliosis (CBD), kaolin pneumoconiosis, and ...
Pneumoconiosis Asbestosis Baritosis Bauxite fibrosis Berylliosis Caplan's syndrome Chalicosis Coalworker's pneumoconiosis ( ...
Aplastic anemia Asbestosis Berylliosis Byssinosis Hodgkins disease Interstitial lung disease Leukemia Lymphoma Manganism ...
... monosomy 2q duplication 1p Chronic berylliosis Chronic bronchitis Chronic demyelinizing neuropathy with IgM monoclonal Chronic ...
Berylliosis (J63.3) Graphite fibrosis (of lung) (J63.4) Siderosis (J63.5) Stannosis (J63.8) Pneumoconiosis due to other ...
Malignancy Lymphoma Carcinoma Mediastinal tumors Inorganic dust disease Silicosis Berylliosis Extrinsic allergic alveolitis ...
... or berylliosis, usually as a result of long-term exposure to beryllium oxide usually caused by inhalation.. ...
... berylliosis MeSH C08.381.483.600.275 --- byssinosis MeSH C08.381.483.600.300 --- caplan's syndrome MeSH C08.381.483.600.750 ...
... and cerebral calcification Berylliosis Beta ketothiolase deficiency Beta-galactosidase-1 deficiency Beta-mannosidosis Beta- ...
... berylliosis, byssinosis, coal dust pneumoconiosis, farmers' lung, hard metal pneumoconiosis, pleural and peritoneal ...
Examples of non-infectious granulomatous diseases are sarcoidosis, Crohn's disease, berylliosis, giant-cell arteritis, ...
... phlebitis of the portal vein granulomatous hepatitis berylliosis sarcoidosis nonalcoholic steatohepatitis (NASH) This may cause ...
Examples of non-infectious granulomatous diseases are sarcoidosis, Crohn's disease, berylliosis, granulomatosis with ...
... berylliosis MeSH C21.447.800.323 --- byssinosis MeSH C21.447.800.340 --- caplan's syndrome MeSH C21.447.800.773 --- siderosis ...
Findings on CT are also not specific to berylliosis. Findings that are common in CT scans of people with berylliosis include ... Some studies suggest that up to 6% of all cases of sarcoidosis are actually berylliosis. Definitive diagnosis of berylliosis is ... Berylliosis has an insidious onset and runs an indolent course. Some people who are sensitized to beryllium may not have ... Berylliosis, or chronic beryllium disease (CBD), is a chronic allergic-type lung response and chronic lung disease caused by ...
Berylliosis. *Brucellosis. *Byssinosis ("brown lung"). *Chalicosis. *Chimney sweeps' carcinoma. *Chronic solvent-induced ...
Berylliosis, fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous ...
Berylliosis Definition Berylliosis is lung inflammation caused by inhaling dust or fumes that contain the metallic element ... Berylliosis. Definition. Berylliosis is lung inflammation caused by inhaling dust or fumes that contain the metallic element ... Acute berylliosis is a serious disease that occasionally may be fatal. Ventilators can help patients with acute berylliosis ... The symptoms of chronic berylliosis are largely the same as those seen in acute berylliosis, but they develop more slowly. ...
... or berylliosis. In acute beryllium disease, the metal acts as a direct chemical irritant, causing a nonspecific inflammatory ... encoded search term (Berylliosis) and Berylliosis What to Read Next on Medscape. Related Conditions and Diseases. * Berylliosis ... Berylliosis. Updated: Dec 31, 2015 * Author: Raed A Dweik, MD, MBA, FACP, FRCPC, FCCP, FCCM, FAHA; Chief Editor: Zab Mosenifar ...
The primary outcome for the aims is the downregulation of Th1 cytokine TNFalpha with the inhibition of the JAK2 using siRNA and the inhibitor INCB018424, CEP-701 and TG101348 in CBD or overexpression of the JAK2 gene ...
Findings on CT are also not specific to berylliosis. Findings that are common in CT scans of people with berylliosis include ... Some studies suggest that up to 6% of all cases of sarcoidosis are actually berylliosis. Definitive diagnosis of berylliosis is ... Berylliosis has an insidious onset and runs an indolent course. Some people who are sensitized to beryllium may not have ... Berylliosis, or chronic beryllium disease (CBD), is a chronic allergic-type lung response and chronic lung disease caused by ...
... berylliosis explanation free. What is berylliosis? Meaning of berylliosis medical term. What does berylliosis mean? ... Looking for online definition of berylliosis in the Medical Dictionary? ... berylliosis. Also found in: Dictionary, Encyclopedia, Wikipedia. Berylliosis. Definition. Berylliosis is lung inflammation ... Acute berylliosis is a serious disease that occasionally may be fatal. Ventilators can help patients with acute berylliosis ...
Discontinued Drugs for Berylliosis (Chronic Beryllium Disease), 2017 List of Chart. Berylliosis (Chronic Beryllium Disease) ... Berylliosis (Chronic Beryllium Disease) Therapeutic Market, US, Marketed Drugs by Application Type, 2017. Berylliosis (Chronic ... Berylliosis (Chronic Beryllium Disease) Marketed Drugs, API Manufacturers by US DMF Status, 2017. Berylliosis (Chronic ... Berylliosis (Chronic Beryllium Disease) Marketed Drugs, API Manufacturers by US DMF Status (%), 2017. Berylliosis (Chronic ...
Learn more about Berylliosis at Reston Hospital Center DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ... Berylliosis is a lung disease that affects people exposed to beryllium. Beryllium is a metallic element that is found in rocks ... Berylliosis is caused by inhalation of beryllium dust or fumes or other exposure such as through an open skin wound. ... Symptoms of chronic berylliosis may not appear until years after exposure. Therefore, all workers who may have been exposed to ...
I know some people are more likely to get berylliosis than others. Which ones? ...
it is also called berylliosis.. Beryllium is a naturally occurring lightweight material that can easily be inhaled in the forms ...
... external resources ICD-10 J63.2 ICD-9 503 Berylliosis or chronic beryllium disorder (CBD) is an occupational lung ... Berylliosis or chronic beryllium disorder (CBD) is an occupational lung disease. It is a chronic allergic-type lung response ... It uses material from the Wikipedia article "Berylliosis". A list of authors is available in Wikipedia. ... Pneumoconiosis (Coalworkers pneumoconiosis, Asbestosis, Silicosis, Bauxite fibrosis, Berylliosis, Siderosis) · Byssinosis · ...
... treatment, manifestations of the Berylliosis, Berylliosis race, Berylliosis function, Berylliosis care, Berylliosis ... Berylliosis case study, Berylliosis diet, Berylliosis subtypes, Berylliosis etymology, Berylliosis clinical trials, Berylliosis ... Berylliosis etiology, Berylliosis clinical features, Berylliosis test, Berylliosis introduction, Berylliosis types, Berylliosis ... Berylliosis medical care, Berylliosis testing, Berylliosis symptoms and signs, Berylliosis genetics, Berylliosis epidemiology, ...
Berylliosis. Symptomatic relief of acute manifestations of berylliosis.j. Aspiration Pneumonitis. Symptomatic relief of acute ...
Berylliosis. Symptomatic relief of acute manifestations of berylliosis.a d f m ...
Berylliosis is chronic damage to the lungs, also called chronic beryllium disease, resulting from industrial exposure to ... Berylliosis - Definition, Symptoms and Treatment. /Pulmonary System / Pulmonary Conditions / Berylliosis - Definition, Symptoms ... Definition of Berylliosis. Berylliosis is chronic damage to the LUNGS, also called chronic beryllium disease, resulting from ... Manufacturing Jobs with High Risk for Berylliosis. MANUFACTURING JOBS WITH HIGH RISK FOR BERYLLIOSIS. ...
Four More Questions About Berylliosis to Discuss With Your Doctor Five Questions About Berylliosis To Ask Your Doctor ...
Berylliosis is a lung disease that affects people exposed to beryllium. Beryllium is a metallic element that is found in rocks ... Berylliosis is caused by inhalation of beryllium dust or fumes or other exposure such as through an open skin wound. ... Symptoms of chronic berylliosis may not appear until years after exposure. Therefore, all workers who may have been exposed to ... Symptoms of acute berylliosis come on suddenly and rapidly. The main symptoms are due to severe lung inflammation. These ...
Liver-disorders; Toxic-substances; Berylliosis; Enzyme-activity; Chlorinated-hydrocarbons; Light-metals; Metal-poisoning; Blood ...
Berylliosis: A disease of the lungs caused by inhaling small particles of the element beryllium.. Biopsy: A procedure in which ... and berylliosis (pronounced buh-ril-ee-O-suhs). The last two diseases are caused by inhaling certain minerals. These diseases ... such as silicosis and berylliosis, which are caused by inhalation of certain minerals, tuberculosis , and certain types of ... Inflammation and scar tissue are sometimes produced in the lung by diseases such as silicosis and berylliosis, which are caused ...
Berylliosis. D001607. EFO:0007168. berylliosis. 1. ClinicalTrials. Nutrition Disorders. D009748. EFO:0001069. nutritional ...
Berylliosis. * Graphite fibrosis (of lung) 516.0 Pneumoconiosis due to other inorganic dust *Aluminosis (of lung) ...
Berylliosis, a case report. Br Med J. 1955;1(4928):1448-50.CrossRefGoogle Scholar ... Berylliosis. Proc R Soc Med. 1955;48:175-7.PubMedGoogle Scholar ... Berylliosis; summary and survey of all clinical types observed ... In vitro demonstration of delayed hypersensitivity in patients with berylliosis. J Invest Dermatol. 1972;58:5-7.CrossRefGoogle ... Chronic beryllium disease (berylliosis). UpToDate 2016. Accessed 7 June 2016.Google Scholar ...
Berylliosis - Definition, Description, Causes and symptoms, Diagnosis, Treatment, Prognosis, Prevention. Berylliosis is lung ... Berylliosis occurs in both acute and chronic forms. In some cases, appearance of the disease may be delayed as much as 20 years ...
  • Given the invasive nature of a lung biopsy diagnosis can also be based on clinical history consistent with berylliosis, abnormal chest x-ray or CT scan findings, an abnormalities in pulmonary function tests. (wikipedia.org)
  • A coronary consultation report dated April 8, 2009 from Dr. Aaron Adams states that the employee had tested positive per Dr. Saab for berylliosis but did not otherwise indicate that such a diagnosis had been confirmed, nor did he cite any test results supporting this diagnosis. (dol.gov)
  • A lymphocyte transformation test (LTT) performed for berylliosis was negative. (ersjournals.com)
  • Findings that are common in CT scans of people with berylliosis include parenchymal nodules in early stages. (wikipedia.org)
  • Its compounds were once used in fluorescent lighting tubes, but this use was discontinued because of berylliosis in the workers manufacturing the tubes (see below). (earth.com)
  • This test is now considered the most definitive diagnostic test for berylliosis. (encyclopedia.com)
  • Patients affected by berylliosis experience cough and shortness of breath. (illnessopedia.org)
  • People who live near such industries have a slightly higher risk of getting berylliosis than those who do not, but the risk is extremely low. (restonhospital.com)
  • I know some people are more likely to get berylliosis than others. (healthtap.com)
  • Chest radiography findings of berylliosis are non-specific. (wikipedia.org)