A group of related plant alkaloids that contain the BERBERINE heterocyclic ring structure.
An alkaloid from Hydrastis canadensis L., Berberidaceae. It is also found in many other plants. It is relatively toxic parenterally, but has been used orally for various parasitic and fungal infections and as antidiarrheal.
Organic nitrogenous bases. Many alkaloids of medical importance occur in the animal and vegetable kingdoms, and some have been synthesized. (Grant & Hackh's Chemical Dictionary, 5th ed)
Alkaloids originally isolated from the ergot fungus Claviceps purpurea (Hypocreaceae). They include compounds that are structurally related to ergoline (ERGOLINES) and ergotamine (ERGOTAMINES). Many of the ergot alkaloids act as alpha-adrenergic antagonists.
Group of alkaloids containing a benzylpyrrole group (derived from TRYPTOPHAN)
A group of ALKALOIDS, characterized by a nitrogen-containing necine, occurring mainly in plants of the BORAGINACEAE; COMPOSITAE; and LEGUMINOSAE plant families. They can be activated in the liver by hydrolysis of the ester and desaturation of the necine base to reactive electrophilic pyrrolic CYTOTOXINS.
A group of indole-indoline dimers which are ALKALOIDS obtained from the VINCA genus of plants. They inhibit polymerization of TUBULIN into MICROTUBULES thus blocking spindle formation and arresting cells in METAPHASE. They are some of the most useful ANTINEOPLASTIC AGENTS.
A plant genus of the family RANUNCULACEAE. Members contain BERBERINE and other isoquinoline ALKALOIDS.
Alkaloids extracted from various species of Cinchona.
Alkaloids derived from TYRAMINE combined with 3,4-dihydroxybenzaldehyde via a norbelladine pathway, including GALANTAMINE, lycorine and crinine. They are found in the Amaryllidaceae (LILIACEAE) plant family.
ISOQUINOLINES with a benzyl substituent.
A plant genus of the family RANUNCULACEAE. Members contain BERBERINE.
A plant genus of the family RANUNCULACEAE. Members contain a number of diterpenoid alkaloids including: aconitans, hypaconitine, ACONITINE, jesaconitine, ignavine, napelline, and mesaconitine. The common name of Wolfbane is similar to the common name for ARNICA.
Dibenzoquinolines derived in plants from (S)-reticuline (BENZYLISOQUINOLINES).
A genus of ascomycetous fungi, family Clavicipitaceae, order Hypocreales, parasitic on various grasses (POACEAE). The sclerotia contain several toxic alkaloids. Claviceps purpurea on rye causes ergotism.
Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.
A plant genus of the family Apocynaceae. It is the source of VINCA ALKALOIDS, used in leukemia chemotherapy.

Characteristics of tetrahydroprotoberberines on dopamine D1 and D2 receptors in calf striatum. (1/114)

AIM: To study the characteristics of tetrahydroprotoberberines (THPB) on dopamine D1 and D2 receptors and elucidate their structure-activity relationship. METHODS: Radioligand assay in vitro with a two-site model program analysis. RESULTS: Four THPB with two hydorxyl groups on C2 and C9 or C2 and C10 exhibited RH and RL two binding sites to D1 receptors and guanosine triphosphate regulated the RH binding site of SPD and THPB-132A in competition assay, while eleven THPB including nonhydroxy-THPB, monohydroxy-THPB, and THPB with two hydroxyl groups attaching to C3 and C10 showed one binding site to D1 receptors under the same conditions. However, the tested eleven THPB all manifested one binding site to D2 receptors in competition assay, and the 2-hydroxy-THPB had the most potent affinity for D2 receptors. CONCLUSION: Dihydroxy-THPB with two hydroxyl groups attaching to C2 and C9 or C2 and C10 possess the intrinsic activity of agonist to D1 receptors, while the other THPB do not. The tested eleven THPB all are the antagonists of D2 receptors.  (+info)

Effects of tetrahydroprotoberberines on dopamine D2 receptors in ventral tegmental area of rat. (2/114)

AIM: To compare the actions of tetrahydroprotoberberines (THPB) on dopamine (DA) D2 receptors in the ventral tegmental area (VTA) of rat. METHODS: Extracellular single unit recording technique was used in i.v. gallamine-paralyzed rats. RESULTS: Eleven THPB analogs tested completely attenuated the apomorphine (Apo, 20 micrograms.kg-1)-induced inhibition on VTA DA cell firing activity. The OH group on C2 at THPB was linked with the reversal of Apo-induced inhibition. Their reversal potencies (ED50, microgram.kg-1) for D2 receptors were: THPB-143 (5.6) > SPD (8.5) > Iso (17.0) > THP (33) > THB (48) > THPB-18 (66) > THPB-1 (179) > THPB-19 (408) > THPB-126 (510) > THPB-104 (1019) > THPB-10 (4815). CONCLUSION: Among these 11 THPB, the 2-hydroxyl-THPB (THPB-143) showed the strongest antagonistic action on D2 receptors.  (+info)

Relationship between electroacupuncture analgesia and dopamine receptors in nucleus accumbens. (3/114)

AIM: To study the roles of dopamine (DA) D1 and D2 receptors in nucleus accumbens in electroacupuncture analgesia (EAA) and the potentiation of EAA of rats induced by l-tetrahydropalmatine (l-THP), a dopamine receptor antagonist. METHODS: SK&F-38393 and quinpirole hydrochloride (Qui), highly selective agonists of D1 and D2 receptors, respectively were injected into nucleus accumbens of rats. RESULTS: SK&F-38393 (5 and 10 micrograms) attenuated the potentiation of EAA induced by l-THP, 10 micrograms SKF38393 attenuated EAA as well, while Qui (10 and 20 micrograms) had no effect on EAA and the potentiation of EAA induced by l-THP. CONCLUSION: D1 but not D2 receptor in nucleus accumbens play an important role in EAA and the potentiation of EAA induced by l-THP.  (+info)

Differential inhibitory effects of protoberberines on sterol and chitin biosyntheses in Candida albicans. (4/114)

The anti-Candida potentials of 12 Korean medicinal plants were explored: methanol extracts from Coptis rhizoma and Phellodendron amurense caused significant inhibition of growth of Candida albicans, Candida glabrata, Candida krusei and Candida parapsilosis. The predominant active components of the extracts were the protoberberines berberine and palmatine; the most potent inhibition of growth was exhibited by berberine on C. krusei (MIC <4 mg/L) and palmatine on C. parapsilosis (MIC 16 mg/L). Both berberine and palmatine inhibited the in-vivo rate of incorporation of L-[methyl-14C]methionine into C-24 of ergosterol in C. albicans (50% inhibition concentration (IC50 values), 25 microM and 300 microM, respectively); this result suggests that sterol 24-methyl transferase (24-SMT) is one of the cellular targets for the antifungal activity of the protoberberines. In-vitro 24-SMT activity in microsomes from the yeast growth form of C. albicans was inhibited by both berberine (inhibition constant (Ki) 232 microM) and palmatine (Ki 257 microM) in a non-competitive manner; inhibition of 24-SMT was more marked for the mycelial form than for the yeast growth form of this organism. Palmatine inhibited chitin synthase from both the yeast and mycelial growth phases of C. albicans in a non-competitive manner (Ki 780 microM). The effects of protoberberines, extracted from established medicinal plants, on both sterol and cell wall biosyntheses in pathogenic fungi indicate that the potential of these compounds, or their semi-synthetic derivatives, as a novel class of antifungal agents should be investigated more fully.  (+info)

Effect of tetrahydropalmatine analogs on Fos expression induced by formalin-pain. (5/114)

AIM: To study the effect of tetrahydropalmatine (THP) analogs on Fos protein expression induced by formalin-pain and elucidate analgesic mechanism of THP analogs. METHODS: The pain response to Sprague Dawley rats was induced with formalin injected s.c. into the plantar surface of the right hindpaw. Fos protein expression in brain and spinal cord was investigated with immunohistochemistry. The numbers of Fos-like immunoreactive (FLI) neurons were counted with Leica Q570 image analyzer. RESULTS: In the groups of THP analogs and D2 antagonist spiperone, FLI neurons induced by intraperitoneal (i.p.) injection of THP analogs and spiperone were mainly located in the striatum and accumbens nucleus, and a few FLI neurons were also in sensorimotor cortex. In the D1 antagonist, D1 agonist, D2 agonist, saline and vehicle groups, FLI neurons were seldom seen in the striatum and accumbens nucleus. Moreover, the Fos protein expression induced by l-THP and spiperone could be prevented by the pre-treatment of the D2 agonist quinpirole but not D1 agonist SKF38393. In the formalin-pain group, FLI neurons were mainly distributed in ascending pain afferent system (APAS) and descending pain modulation system (DPMS). Following i.p. THP analogs, however, the numbers of FLI neurons induced by formalin-pain in the APAS, such as dorsal horn (mainly laminae I, II, IV-VI) were markedly decreased, while the numbers of FLI neurons in the DPMS, such as periaqueductal gray (PAG) and reticular paragigantocellular lateral nucleus (RPLN) were significantly increased. CONCLUSION: THP analogs enhanced the activity of brainstem DPMS by the blockade of D2 receptors in the striatum and accumbens nucleus, and sequentially inhibited the inputs of peripheral pain afferent message in spinal cord level.  (+info)

Effect of protopine on cytosolic Ca2+ in rabbit platelets. (6/114)

AIM: To study the influence of protopine (Pro) on the cytoplasmic free Ca2+ concentration ([Ca2+]i) in rabbit platelets. METHODS: Measurement of [Ca2+]i of platelets in vitro by Fura 2-AM fluorescence technique. RESULTS: In the presence of CaCl2 1 mmol.L-1, Pro 10, 20, and 40 mumol.L-1 attenuated the rise in [Ca2+]i evoked by ADP from (420 +/- 57) to (320 +/- 26), (264 +/- 21), and (180 +/- 14) nmol.L-1, respectively, by arachidonic acid (AA) from (280 +/- 36) to (210 +/- 17), (184 +/- 21), and (143 +/- 16) nmol.L-1, respectively, and by platelet-activating factor (PAF) from (350 +/- 42) to (282 +/- 31), (223 +/- 30), and (165 +/- 15) nmol.L-1, respectively. In the presence of egtazic acid 1 mmol.L-1, Pro 10, 20, and 40 mumol.L-1 reduced the Ca2+ release induced by ADP, AA, and PAF, respectively. Pro 10, 20, and 40 mumol.L-1 also decreased ADP-, AA-, and PAF-induced Ca2+ influx. CONCLUSION: Pro inhibited not only Ca2+ release but also the influx of Ca2+.  (+info)

Supraspinal D2 receptor involved in antinociception induced by l-tetrahydropalmatine. (7/114)

AIM: To study the role of dopamine (DA) receptors in l-tetrahydropalmatine (l-THP)-induced antinociception. METHODS: The intraperitoneal (i.p.) and intrathecal (ith) injections were used to give the drugs. The tail-flick test was used to assess the nociceptive threshold of rats. RESULTS: By i.p. injection, l-THP (10, 20, 40 mg.kg-1) as well as D2 receptor antagonist spiperone (1, 2, 3 mg.kg-1) produced dose-dependent antinociceptive effects on the nociception of rats, while D2 receptor agonist quinpirole, D1 receptor agonist SKF38393, and D1 receptor antagonist Sch-23390 showed no antinociception. Moreover, l-THP- or spiperone-induced antinociception was markedly attenuated by quinpirole (2, 3 mg.kg-1) but not SKF38393 or naloxone. On the other hand, ith quinpirole (20, 30, 40 micrograms.kg-1) also induced a dose-dependent antinociception, while ith l-THP, spiperone, SKF38393, and Sch-23390 did not exhibit any antinociception. Furthermore, ith spiperone (20, 30, 40 micrograms.kg-1) but not Sch-23390 dose-dependently antagonised the antinociception induced by quinpirole. l-THP (ith, 100, 200, 300 micrograms.kg-1) also dramatically attenuated the quinpirole-induced antinociception with a dose-dependent relationship. CONCLUSION: Activating the spinal D2 receptor or blocking the supraspinal D2 receptor produces antinociception. D1 receptor might be not directly involved in the antinociception. l-THP (as a D2 antagonist) as well as spiperone produces antinociception via blocking the supraspinal D2 receptor.  (+info)

Electrophysiological effects of protopine in cardiac myocytes: inhibition of multiple cation channel currents. (8/114)

Protopine (Pro) from Corydalis tubers has been shown to have multiple actions on cardiovascular system, including anti-arrhythmic, anti-hypertensive and negative inotropic effects. Although it was thought that Pro exerts its actions through blocking Ca(2+) currents, the electrophysiological profile of Pro is unclear. The aim of this study is to elucidate the ionic mechanisms of Pro effects in the heart. In single isolated ventricular myocytes from guinea-pig, extracellular application of Pro markedly and reversibly abbreviates action potential duration, and decreases the rate of upstroke (dV/dt)(max), amplitude and overshoot of action potential in a dose-dependent manner. Additionally, it produces a slight, but significant hyperpolarization of the resting membrane potential. Pro at 25, 50 and 100 microM reduces L-type Ca(2+) current (I(Ca,L)) amplitude to 89.1, 61.9 and 45.8% of control, respectively, and significantly slows the decay kinetics of I(Ca,L) at higher concentration. The steady state inactivation of I(Ca,L) is shifted negatively by 5.9 - 7.0 mV (at 50 - 100 microM Pro), whereas the voltage-dependent activation of I(Ca,L) remains unchanged. In contrast, Pro at 100 microM has no evident effects on T-type Ca(2+) current (I(Ca,T)). In the presence of Pro, both the inward rectifier (I(K1)) and delayed rectifier (I(K)) potassium currents are variably inhibited, depending on Pro concentrations. Sodium current (I(Na)), recorded in low [Na(+)](o) (40 mM) solution, is more potently suppressed by Pro. At 25 microM, Pro significantly attenuated I(Na) at most of the test voltages (-60 approximately +40 mV, with a 53% reduction at -30 mV. Thus, Pro is not a selective Ca(2+) channel antagonist. Rather, it acts as a promiscuous inhibitor of cation channel currents including I(Ca,L), I(K), I(K1) as well as I(Na). These findings may provide some mechanistic explanations for the therapeutic actions of Pro in the heart.  (+info)

Berberine alkaloids are a type of natural compound found in several plants, including the Berberis species (such as barberry and tree turmeric), goldenseal, Oregon grape, and phellodendron. The most well-known and researched berberine alkaloid is berberine itself, which has a yellow color and is commonly used in traditional medicine for various purposes, such as treating diarrhea, reducing inflammation, and combating bacterial and fungal infections.

Berberine alkaloids have a complex chemical structure that includes a nitrogen atom, making them basic in nature. They are known to interact with several biological targets, including enzymes and receptors, which contributes to their diverse pharmacological activities. Some of the key mechanisms of action of berberine alkaloids include:

1. Inhibition of DNA gyrase: Berberine alkaloids can interfere with bacterial DNA replication by inhibiting the activity of DNA gyrase, an enzyme that helps to unwind and supercoil DNA during replication. This makes them effective against a wide range of bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE).
2. Interaction with cell membranes: Berberine alkaloids can interact with the lipid bilayer of cell membranes, disrupting their integrity and increasing permeability. This can lead to the death of bacteria, fungi, and cancer cells.
3. Modulation of gene expression: Berberine has been shown to regulate the expression of various genes involved in metabolic processes, inflammation, and cell growth. For example, it can activate AMP-activated protein kinase (AMPK), a key enzyme that regulates energy metabolism, which may contribute to its potential benefits in treating diabetes, obesity, and nonalcoholic fatty liver disease.
4. Inhibition of inflammatory mediators: Berberine alkaloids can inhibit the production of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6), which are involved in the development of various inflammatory diseases.
5. Antioxidant activity: Berberine alkaloids have antioxidant properties, which can help protect cells from damage caused by reactive oxygen species (ROS). This may contribute to their potential benefits in treating neurodegenerative disorders and cancer.

In summary, berberine alkaloids exhibit a wide range of pharmacological activities, including antibacterial, antifungal, anti-inflammatory, antioxidant, and metabolic regulatory effects. These properties make them promising candidates for the development of new therapeutic agents to treat various diseases, such as infections, inflammation, diabetes, obesity, and cancer. However, further research is needed to fully understand their mechanisms of action and potential side effects before they can be safely and effectively used in clinical settings.

Berberine is a chemical found in several plants including European barberry, goldenseal, goldthread, Oregon grape, phellodendron, and tree turmeric. It has a yellow color and has been used in traditional medicine for various purposes such as treating diarrhea, reducing inflammation, and fighting bacteria.

Berberine has been studied for its potential health benefits, including its ability to lower blood sugar levels, reduce cholesterol and triglycerides, and improve cardiovascular health. It is thought to work by activating AMP-activated protein kinase (AMPK), an enzyme that plays a role in regulating metabolism.

However, more research is needed to fully understand the potential benefits and risks of berberine, and it should not be used as a substitute for medical treatment. As with any supplement, it's important to talk to your doctor before taking berberine or any other herbal remedy.

Alkaloids are a type of naturally occurring organic compounds that contain mostly basic nitrogen atoms. They are often found in plants, and are known for their complex ring structures and diverse pharmacological activities. Many alkaloids have been used in medicine for their analgesic, anti-inflammatory, and therapeutic properties. Examples of alkaloids include morphine, quinine, nicotine, and caffeine.

Ergot alkaloids are a type of chemical compound that is produced naturally by certain fungi belonging to the genus Claviceps. These alkaloids are most famously known for being produced by the ergot fungus (Claviceps purpurea), which infects cereal grains such as rye and causes a condition known as ergotism in humans and animals that consume the contaminated grain.

Ergot alkaloids have a complex chemical structure and can have various effects on the human body. They are known to act as powerful vasoconstrictors, which means that they cause blood vessels to narrow and can increase blood pressure. Some ergot alkaloids also have psychoactive effects and have been used in the past for their hallucinogenic properties.

In modern medicine, certain ergot alkaloids are used in the treatment of various conditions, including migraines and Parkinson's disease. However, these compounds can be highly toxic if not used properly, and their use must be carefully monitored to avoid serious side effects.

Indole alkaloids are a type of naturally occurring organic compound that contain an indole structural unit, which is a heterocyclic aromatic ring system consisting of a benzene ring fused to a pyrrole ring. These compounds are produced by various plants and animals as secondary metabolites, and they have diverse biological activities. Some indole alkaloids have important pharmacological properties and are used in medicine as drugs or lead compounds for drug discovery. Examples of medically relevant indole alkaloids include reserpine, which is used to treat hypertension, and vinblastine and vincristine, which are used to treat various types of cancer.

Pyrrolizidine alkaloids (PAs) are a group of naturally occurring chemical compounds found in various plants, particularly in the families Boraginaceae, Asteraceae, and Fabaceae. These compounds have a pyrrolizidine ring structure and can be toxic or carcinogenic to humans and animals. They can contaminate food and feed sources, leading to poisoning and health issues. Chronic exposure to PAs has been linked to liver damage, veno-occlusive disease, and cancer. It is important to avoid consumption of plants containing high levels of PAs and to monitor food and feed sources for PA contamination.

Vinca alkaloids are a group of naturally occurring chemicals derived from the Madagascar periwinkle plant, Catharanthus roseus. They are known for their antineoplastic (cancer-fighting) properties and are used in chemotherapy to treat various types of cancer. Some examples of vinca alkaloids include vinblastine, vincristine, and vinorelbine. These agents work by disrupting the normal function of microtubules, which are important components of the cell's structure and play a critical role in cell division. By binding to tubulin, a protein that makes up microtubules, vinca alkaloids prevent the formation of mitotic spindles, which are necessary for cell division. This leads to cell cycle arrest and apoptosis (programmed cell death) in cancer cells. However, vinca alkaloids can also affect normal cells, leading to side effects such as neurotoxicity, myelosuppression, and gastrointestinal disturbances.

Coptis is a genus of flowering plants in the family Ranunculaceae, also known as coptis or goldthread. The name "Coptis" is derived from the Greek word "koptos," which means "cutting" or "engraved," referring to the shape of the root.

In a medical context, Coptis species, particularly Coptis chinensis and Coptis japonica, have been used in traditional Chinese medicine for centuries. The rhizomes (underground stems) of these plants contain various alkaloids, including berberine, which has been studied for its potential medicinal properties.

Berberine has been found to have antimicrobial, anti-inflammatory, and antioxidant effects, among others. It has been used in traditional medicine to treat a variety of conditions, such as gastrointestinal disorders, skin diseases, and infections. However, more research is needed to fully understand the potential benefits and risks of using Coptis or its constituents for medicinal purposes.

It's important to note that while some natural substances like berberine have shown promise in preliminary studies, they should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult with a healthcare provider before starting any new supplement regimen.

Cinchona alkaloids are a group of naturally occurring chemical compounds that are found in the bark of Cinchona trees, which are native to South America. These alkaloids have been used for centuries in traditional medicine to treat various ailments, most notably malaria. The main cinchona alkaloids include quinine, quinidine, cinchonine, and cinchonidine.

Quinine is the most well-known of these alkaloids and has been used for centuries as an effective antimalarial agent. It works by interfering with the reproduction of the malaria parasite in the red blood cells. Quinine is also used to treat other medical conditions, such as leg cramps and restless legs syndrome.

Quinidine is another important cinchona alkaloid that is used primarily as an antiarrhythmic agent to treat irregular heart rhythms. It works by slowing down the electrical conduction in the heart and stabilizing its rhythm.

Cinchonine and cinchonidine have more limited medical uses, mainly as bitter-tasting ingredients in tonics and other beverages. However, they also have some medicinal properties, such as being used as antimalarial agents and antiarrhythmic drugs in some countries.

It is important to note that cinchona alkaloids can have serious side effects if not used properly, so they should only be taken under the supervision of a healthcare professional.

Amaryllidaceae alkaloids are a type of naturally occurring chemical compounds that are found in plants belonging to the Amaryllidaceae family, which includes amaryllis, snowdrop, and daffodil species. These alkaloids have diverse pharmacological activities and have been studied for their potential medicinal properties. Some well-known Amaryllidaceae alkaloids include lycorine, galanthamine, and haemantamine.

Lycorine has been shown to have antiviral, antimalarial, and anti-cancer properties. Galanthamine is a reversible acetylcholinesterase inhibitor that has been used in the treatment of Alzheimer's disease. Haemantamine has been studied for its potential as an anti-arrhythmic agent.

It is important to note that while Amaryllidaceae alkaloids have shown promise in preclinical studies, further research is needed to determine their safety and efficacy in humans before they can be approved for medical use. Additionally, some of these alkaloids can be toxic in high concentrations, so it is important to exercise caution when handling or consuming plants that contain them.

Benzylisoquinolines are a type of naturally occurring organic compounds found in various plants. These compounds are derived from the combination of a benzyl group and an isoquinoline ring, hence the name "benzylisoquinolines." They are known to have diverse biological activities, including anti-inflammatory, antispasmodic, and antimicrobial properties. Some well-known examples of benzylisoquinoline alkaloids include papaverine, found in the opium poppy, and berberine, found in various medicinal plants such as goldenseal and barberry. These compounds have been used in traditional medicine for centuries and continue to be studied for their potential therapeutic uses.

Hydrastis is the genus name for Hydrastis canadensis, also known as goldenseal. It is a perennial herb native to North America, and its roots and rhizomes have been used in traditional medicine for various purposes. The active compounds in goldenseal include alkaloids such as hydrastine, berberine, and canadine, which are believed to have antibacterial, anti-inflammatory, and astringent properties.

However, it is important to note that the use of Hydrastis and its preparations as a medicine should be under the guidance of a healthcare professional, as there may be potential risks and interactions with other medications. Additionally, overharvesting of goldenseal in the wild has led to concerns about its sustainability, so it is recommended to use cultivated sources instead.

Aconitum, also known as monkshood or wolf's bane, is a genus of extremely poisonous plants belonging to the family Ranunculaceae. These plants are native to the mountainous regions of the Northern Hemisphere, especially in Asia. The name Aconitum comes from the Greek word "akonitos," which is believed to be derived from "akone," meaning "dart" or "pointed stake," referring to the shape of the plant's roots and its use as a poison on weapons.

The plants contain various alkaloids, primarily aconitine, which is responsible for their toxicity. All parts of the plant are considered poisonous, but the roots and seeds contain the highest concentration of aconitine. Ingesting or touching any part of the Aconitum plant can cause severe symptoms, including nausea, vomiting, diarrhea, heart problems, paralysis, and even death if not treated promptly.

In traditional medicine, some species of Aconitum have been used in small, controlled doses to treat various ailments, such as pain, inflammation, and heart conditions. However, due to the high risk of toxicity, these uses are generally discouraged in modern medicine, and safer alternatives are recommended.

Aporphine is a type of chemical compound called alkaloids, which are found in certain plants. Aporphines have a specific chemical structure and can have various pharmacological effects. They have been studied for their potential medicinal properties, including anti-inflammatory, antispasmodic, and antiasthmatic activities. Some aporphine alkaloids have also been found to have psychoactive effects and are used in traditional medicine in some cultures. However, more research is needed to fully understand the therapeutic potential and safety of aporphines.

'Claviceps' is a genus of filamentous fungi that are commonly known as ergots. These fungi infect the grasses and grains in the family Poaceae, which includes important crop plants such as wheat, rye, barley, and corn. The most well-known species in this genus is Claviceps purpurea, which causes a disease called ergotism in humans and animals that consume contaminated grains.

Ergotism is a serious condition that can cause a range of symptoms, including convulsions, hallucinations, gangrene, and death. The fungus produces alkaloids that can affect the nervous system and blood vessels, leading to these symptoms. Historically, ergotism was a significant public health problem in Europe, where it was known as "St. Anthony's Fire" because of the burning sensations it caused in the limbs.

Today, ergotism is rare thanks to improved grain storage and monitoring practices. However, Claviceps species continue to be important in agriculture and medicine. Some of the alkaloids produced by these fungi have been used in pharmaceuticals to treat conditions such as migraines and Parkinson's disease.

A plant extract is a preparation containing chemical constituents that have been extracted from a plant using a solvent. The resulting extract may contain a single compound or a mixture of several compounds, depending on the extraction process and the specific plant material used. These extracts are often used in various industries including pharmaceuticals, nutraceuticals, cosmetics, and food and beverage, due to their potential therapeutic or beneficial properties. The composition of plant extracts can vary widely, and it is important to ensure their quality, safety, and efficacy before use in any application.

'Catharanthus' is a genus of plants in the Apocynaceae family, commonly known as the dogbane family. The most well-known species is Catharanthus roseus, also known as Madagascar periwinkle or rosy periwinkle. This plant contains alkaloids that have been used in the production of drugs for cancer treatment. Vincristine and vinblastine are two such alkaloids derived from C. roseus, which have shown significant anti-cancer properties and are used to treat various types of cancers, including leukemia and lymphoma.

It is important to note that the use of Catharanthus or its derivatives should be under medical supervision due to their potent biological activities and potential side effects.

This enzyme participates in alkaloid biosynthesis i. It employs one cofactor, iron. Rueffer M, Zenk MH (1985). "Berberine ... 2 berberine + 2 H2O Thus, the two substrates of this enzyme are columbamine and O2, whereas its two products are berberine and ... synthesis, the methylenedioxy group forming enzyme in berberine synthesis". Tetrahedron Lett. 26 (2): 201-202. doi:10.1016/ ... This enzyme is also called berberine synthase. ...
The chemical constituents include isoquinolone alkaloids, especially berberine. A full list of phytochemicals was compiled and ... The safety of using berberine for any condition is not adequately defined by high-quality clinical research. Its potential for ... doi:10.4103/0973-7847.125517 "Berberine: MedlinePlus Supplements". MedlinePlus, National Library of Medicine, US National ...
Some alkaloids are colored, like berberine (yellow) and sanguinarine (orange). Most alkaloids are weak bases, but some, such as ... of those contain alkaloids. Therefore, in the past the term "alkaloid" was associated with plants. The alkaloids content in ... attributed to isoquinoline alkaloids. Main classes of monomeric alkaloids are listed in the table below: Most alkaloids contain ... Most alkaloids are present in the raw plants in the form of salts of organic acids. The extracted alkaloids may remain salts or ...
Gupta S, Singh N, Jaggi AS (March 2014). "Alkaloids as aldose reductase inhibitors, with special reference to berberine". ... AKR1B1 has been found to interact with: ginsenoside 20(S)-Rh2 alkaloid carboxylic acid derivatives spirohydantoins cyclic ...
Reticuline is the immediate precursor of protoberberine alkaloids in plants. Berberine is an alkaloid derived from tyrosine. L- ... Berberine is usually found in the roots, rhizomes, stems, and bark. The alkaloid berberine has a tetracyclic skeleton derived ... Berberine is a quaternary ammonium salt from the protoberberine group of benzylisoquinoline alkaloids Due to its yellow color, ... As a natural dye, berberine has a color index of 75160. There is poor-quality evidence that berberine might help with various ...
This enzyme participates in alkaloid biosynthesis i. Steffens P, Nagakura N, Zenk MH (1984). "The berberine bridge forming ... berberine bridge enzyme, berberine-bridge-forming enzyme, and tetrahydroprotoberberine synthase. ... doi:10.1016/S0040-4039(01)80070-8. Dittrich H, Kutchan TM (1991). "Molecular cloning, expression, and induction of berberine ... Kutchan TM, Dittrich H (1995). "Characterization and mechanism of the berberine bridge enzyme, a covalently flavinylated ...
Bauer W, Zenk MH (1991). "Formation of (R)-configurated tetrahydroprotoberberine alkaloids in vivo and in vitro". Tetrahedron ... Berberine reductase (EC 1.5.1.31) is an enzyme that catalyzes the chemical reaction (R)-canadine + 2 NADP+ ⇌ {\displaystyle \ ... rightleftharpoons } berberine + 2 NADPH + H+ Thus, the two substrates of this enzyme are (R)-canadine and nicotinamide adenine ... dinucleotide phosphate ion, whereas its 3 products are berberine, nicotinamide adenine dinucleotide phosphate, and hydrogen ion ...
Crude extracts of Nectandra contain alkaloids and lignans, berberine and sipirine. Some authors have postulated that tannins ...
The alkaloid berberine upregulates the expression of HNF4A. This gene also plays a pivotal role in the expression and synthesis ... Wang ZQ, Lu FE, Leng SH, Fang XS, Chen G, Wang ZS, Dong LP, Yan ZQ (Oct 2008). "Facilitating effects of berberine on rat ...
... contains berberine In general, isoquinoline alkaloids can have different effects. The opium alkaloids may have sedative, ... Morphine Codeine Papaverine Berberine Tubocurarine The isoquinoline alkaloids are primarily formed in the plant families of ... An example of the Berberidaceae with the ingredient berberine is Berberis vulgaris. The alkaloid tubocurarin is found in the ... Isoquinoline alkaloids are natural products of the group of alkaloids, which are chemically derived from isoquinoline. They ...
The active compounds of Coptis trifolia are the alkaloids berberine and coptine. In 1963, a species of fungus in the genus ...
The roots of both species contain berberine, a known anti-tumor alkaloid. The plant is therefore considered poisonous. Native ...
It is also believed to help insomnia in Chinese herbology.[citation needed] The roots contain the bitter alkaloid berberine. ...
S)-Canadine, berberine, palmatine, and hydrastine are the major alkaloids present in goldenseal. A number of in vitro effects ... S)-Canadine is the immediate metabolic precursor of berberine, which is obtained through the action of the enzyme (S)- ... It is also an intermediate in the complex biosynthesis of noscapine, which is likewise a benzylisoquinoline alkaloid, but of ... S)-Canadine, also known as (S)-tetrahydroberberine and xanthopuccine, is a benzylisoquinoline alkaloid (BIA), of the ...
Plastoquinone Conjugated with Cationic Plant Alkaloids Berberine and Palmatine". Pharmaceutical Research. 28 (11): 2883-2895. ... The cations with the well-known medical properties - berberine and palmatine were also tested. SkQBerb and SkQPalm - SkQ ...
Related compounds in the plant are berberine and protopine, among other minor alkaloids. Bloodroot produces benzylisoquinoline ... Sanguinarine is a benzophenanthridine alkaloid (see phenanthridine), which, unlike most other alkaloids, has a red color in ... The alkaloids are transported to and stored in the rhizome. Sanguinarine kills animal cells by blocking the action of Na+/K+- ... "PATHWAY: Alkaloid biosynthesis I - Reference pathway". Kyoto Encyclopedia of Genes and Genomes (KEGG). "ENZYME: 1.14.13.71". ...
... is an alkaloid isolated originally from Phellodendron amurense (Rutaceae). Berberine Jatrorrhizine Palmatine ... Benzylisoquinoline alkaloids, Quaternary ammonium compounds, Phenol ethers, Isoquinolinoisoquinolines, Phenols, Methoxy ... SHIMAMOTO K, JUJIHARA M, TORII H (March 1962). "[Pharmacological studies on phellodendrine, the quaternary ammonium alkaloid ...
It is an organic heterotetracyclic compound and a berberine alkaloid. Columbamine can be also called dehydroisocorypalmine. It ... Alkaloids, Heterocyclic compounds with 4 rings, Methoxy compounds, Nitrogen heterocycles, Quaternary ammonium compounds). ...
Isoquinoline alkaloids, Quinoline alkaloids, Quaternary ammonium compounds, Alkaloids found in Papaveraceae, Toxins). ... Berberine, a plant-derived compound having a chemical classification similar to that of sanguinarine. Chelidonine Santos AC, ... Sanguinarine is a polycyclic quaternary alkaloid. It is extracted from some plants, including the bloodroot plant, from whose ... reticuline is converted to scoulerine via berberine bridge enzyme (BBE). As such, this is the commitment step in the ...
Several species of Berberis contain alkaloids such as berberine, canadine, columbamine, corypalmine, jatrorrhizine, and ... These alkaloids are all very similar in chemical structure, but they vary in the effects they have on humans. Protoberberine ... Berberine, at high dosages, has been known to cause seizures and inhibit enzymes. Berberis can have adverse side effects such ...
The stem and the roots contain quaternary alkaloids, such as berberine, palmatine, magnoflorine and columbamine. The seeds ... March 1981). "Studies on Indonesian Medicinal Plants V. The Alkaloids of Anamirta cocculus". Journal of Natural Products. 44 (2 ... deliver picrotoxin, a sesquiterpene, while the seed shells contain the tertiary alkaloids menispermine and paramenispermine. ...
Kulkarni, S. K.; Dhir, Ashish (2010). "Berberine: A plant alkaloid with therapeutic potential for central nervous system ... This and many other related species contain the alkaloid berberine, a chemical being studied for its therapeutic potential. ...
On the relation between the absorption spectra & the chemical structure of corydaline, berberine, and other alkaloids". {{cite ... The alkaloids of corydalis cava : Part II. ...
chinensis) The rhizomes of Coptis chinensis contain the isoquinoline alkaloids berberine, palmatine, and coptisine among others ... Because of the strong coloring quality of berberine, it has been traditionally used as a dye, especially for wool and other ... Gibbs, Peter J.; Seddon, Kenneth R. (1998). Berberine and Huangbo: Ancient Colorants and Dyes. London: British Library. ISBN ...
The fruits are rich in Vitamin C. The bark contains an alkaloid, Berberine. It stimulates the uterus and the intestine. It may ...
The condensation of 4-hydroxyphenylacetaldehyde and dopamine is a key step in the biosynthesis of benzylisoquinoline alkaloids ... These natural products include berberine and morphine. "4-Hydroxyphenylacetaldehyde". PubChem Compound. U.S. National Library ... an enzyme catalyzing the first committed step in benzylisoquinoline alkaloid biosynthesis". Plant Journal. 40 (2): 302-313. doi ...
Her doctoral dissertation, titled Investigation of Isoquinoline Alkaloids: Examination of Pictet's Berberine Synthesis, was ... Outside of these two projects, Davis's research interests included synthesis of alkaloids, catalytic reduction of certain ... Rose May Davis, The Reactivity of Doubly-Conjugated Ketones Rose May Davis, Investigation of Isoquinoline Alkaloids: ... Examination of Pictet's Berberine Synthesis Marilyn Ogilvie and Joy Harvey, editors, "Davis, Rose May" The Biographical ...
In Asia it is grown for medicinal purposes, with the main alkaloid being berberine. Rhizomes partly prepared for herbal ... in alkaloid transport in Coptis japonica". Proceedings of the National Academy of Sciences. 100 (2): 751-756. doi:10.1073/pnas. ...
Berberine bridge enzyme (BBE) is a central enzyme in the biosynthesis of berberine, a pharmaceutically important alkaloid. The ... On the other hand, berberine is highly regarded for its interactions with several diseases. Berberine has been known to ... These quaternary alkaloids have a strong inhibitory effect on the BBE, so they had to be removed. In order to eliminate most of ... Berberine bridge enzyme-like (BBE-like enzymes) form a subgroup of the superfamily of FAD-linked oxidases (SCOPe d.58.32), ...
Carter CJ, Thornburg RW (January 2004). "Tobacco nectarin V is a flavin-containing berberine bridge enzyme-like protein with ... a covalently flavinylated oxidase of benzophenanthridine alkaloid biosynthesis in plants". The Journal of Biological Chemistry ... Its amino acid sequence is partly (40-50%) homologous to several other oxidoreductases, such as berberine bridge enzyme in ... Kutchan TM, Dittrich H (October 1995). "Characterization and mechanism of the berberine bridge enzyme, ...
This enzyme participates in alkaloid biosynthesis i. It employs one cofactor, iron. Rueffer M, Zenk MH (1985). "Berberine ... 2 berberine + 2 H2O Thus, the two substrates of this enzyme are columbamine and O2, whereas its two products are berberine and ... synthesis, the methylenedioxy group forming enzyme in berberine synthesis". Tetrahedron Lett. 26 (2): 201-202. doi:10.1016/ ... This enzyme is also called berberine synthase. ...
Berberine (alkaloid). *. Flaxseed oil. *. Sulforaphane (phytochemical). *. Ginger. These antioxidants re-establish homeostasis ...
This work demonstrates the potential of the barberry crude extract and its active alkaloid, berberine, on suppressing lipid ... of barberry crude extract and berberine active compound. The effect of B. vulgaris extract and berberine chloride on cellular ... On the other hand, the effect of extract and berberine as anticancer was estimated on three different cell lines which were MCF ... Inhibitory effect of berberis crude extract on α-glucosidase was more potent than that of berberine chloride, while both had ...
Here, we demonstrate that a berberine fumarate (BF) has a hypoglycemic effect by regulating the intestinal microflora and ... Administration of berberine fumarate significantly ameliorated the metabolic disorder; increased the populations of ... Berberine is an isoquinoline alkaloid extracted from the rhizomes of Ranunculaceae coptis or Cortex phellodendri. A number of ... Studies have shown that berberine organic acids can reduce blood glucose and have the good effects of berberine hydrochloride [ ...
Several protoberberine alkaloids including berberine, jatrorrhizine and palmatine were previously measured against MRSA strains ... the indole alkaloid, reserpine, is a known NorA efflux pump inhibitor and exhibited a synergistic effect with ciprofloxacin (14 ... Jatrorrhizine is one of the main protoberberine alkaloids widely distributed among Mahonia and Berberis species (15). In the ...
Berberine (BBR) is a bioactive alkaloid which can be isolated from several Chinese herbs, such as Hydrastis canadensis, ... Background and Objective: Berberine (BBR) is an alkaloid with many pharmaceutical activities. The BBR inhibits the ... Effects of berberine on diabetes induced by alloxan and a high-fat/high-cholesterol diet in rats. J. Ethnopharmacol., 108: 109- ... Berberine displays antitumor activity in esophageal cancer cells in vitro. World J. Gastroenterol., 23: 2511-2518.. CrossRef ...
Plants containing quinolizidine alkaloids with known toxicity include the following: Baptisia species (false indigo) Cytisus ... heterogeneous group of alkaloids with members of each group having known toxicity to humans and domestic animals. ... The toxic isoquinoline alkaloids include papaverine, sanguinarine, dihydrosanguinarine, protoverine, berberine, coptisine, ... Lupinus species contain sparteine, a tetracyclic quinolizidine alkaloid, and lupinine, a bicyclical quinolizidine alkaloid. ...
New clinical applications for the alkaloid berberine have come to light in recent years. Applications related to adenosine ... monophosphate-activated protein kinase (AMPK) activation and berberines possible therapeutic use in metabolic syndrome, type 2 ...
Berberine is a barberry root extract used to support healthy glucose metabolism, support blood sugar balance & cardiovascular ... Berberine is an alkaloid that occurs naturally in certain medicinal plants. It is a fantastic option for people who want to ... 2008). Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. J Clin Endocrinol, 93(7), 2559- ... Berberine 500mg Vegetarian Capsules. Berberine 500mg Vegetarian Capsules Size. 90 Vegetarian CapsulesVariant sold out or ...
What is berberine? Berberine is an alkaloid that belongs to the group of isoquinolinalkaloids, of which more than 600 are known ... Buy berberine supplement now! highly dosed 500mg berberine HCl per capsule equivalent to 485mg berberine per capsule combined ... The alkaloid occurs naturally in various plants, including barberry (Berberis aristata), to which it owes its name. Berberine ... Berberine 500mg - 90 Capsules 52909 High-dose Berberine capsules This food supplement contains as a valuable ingredient ...
Fan D, Liu L, Wu Z, Cao M. Combating Neurodegenerative Diseases with the Plant Alkaloid Berberine: Molecular Mechanisms and ... Berberine chloride (HY-18258, purity 99.16%) was purchased from MedChemExpress (MCE, NJ, USA), Berberine hydrochloride tablets ... Durairajan S, Liu L, Lu J, Chen L, Yuan Q, Chung S, Huang L, Li X, Huang J, Li M. Berberine ameliorates β-amyloid pathology, ... Wang Y, Yan Q, Huang Z, Zou Q, Li J, Yuan M, Wu L, Cai Z. Ameliorating Ribosylation-Induced Amyloid-β Pathology by Berberine ...
Molecular mechanisms of action of herbal antifungal alkaloid berberine, in Candida albicans. PLoS One. 2014; 9(8):e104554. ...
Berberine could serve as a potential candidate for the treatment of several diseases. Previous literature has provided a basis ... Berberine is the main active compound of different herbs and is defined as an isoquinoline quaternary botanical alkaloid found ... Berberine: Pharmacological Features in Health, Disease and Aging Curr Med Chem. 2024;31(10):1214-1234. doi: 10.2174/ ... Conclusion: Berberine could serve as a potential candidate for the treatment of several diseases. Previous literature has ...
The root contains alkaloids (berberine - 3-4%, hydrastine - 2-4%, canadine), calcium, iron, manganese, albumin, fatty matter, ... Graviola acts as an antidepressant due to the novel alkaloids found in its seeds and roots. However, one should be very careful ... Alkaloids, tannins, and saponins, as well as vitamins and minerals are also presented in maca root. ... Key components of the herb are volatile oils, essential oil, terpenes, lactone glycoside, alkaloid, sterols, saponins, ferulic ...
... the main active constituent of phellodendron which is an alkaloid of the isoquinoline group to ensure optimal strength and ... Berberine Active is standardized to contain 200 mg of berberine, ... Berberine Active contains Phellodendron used traditionally to ... Containing berberine 200 mg). Other Ingredients: Microcrystalline cellulose, sodium starch glycolate, croscarmellose sodium, ...
Berberine : Berberine possesses a bitter taste and exhibits antibacterial and amoebicidal properties. Recent studies have ... Alkaloids : Despite its esteemed medicinal reputation, goldenseals pharmacology has been relatively underexplored. However, it ... Isoquinoline alkaoids (berberine, hydrastine, and canadine), flavonoids.( aglycones, chalcones, flavan-3-ols, flavanones, ... Canadine : Research shows that this alkaloid stimulates the muscles of the uterus. ...
BERBERINE ALKALOIDS. CHLAMYDIA PNEUMONIAE. CHLAMYDOPHILA PNEUMONIAE. CHLAMYDIA PSITTACI. CHLAMYDOPHILA PSITTACI. COMPOUND 48-80 ...
BERBERINE ALKALOIDS. CHLAMYDIA PNEUMONIAE. CHLAMYDOPHILA PNEUMONIAE. CHLAMYDIA PSITTACI. CHLAMYDOPHILA PSITTACI. COMPOUND 48-80 ...
BERBERINE ALKALOIDS. CHLAMYDIA PNEUMONIAE. CHLAMYDOPHILA PNEUMONIAE. CHLAMYDIA PSITTACI. CHLAMYDOPHILA PSITTACI. COMPOUND 48-80 ...
... also known as berberine hydrochloride is a bioactive compound that can be extracted from several different plants, including a ... It belongs to a class of compounds called alkaloids. It has a yellow color, and has often been used as a dye. ... Decrease quantity for 1 Berberine HCL - 120 Capsules Increase quantity for 1 Berberine HCL - 120 Capsules ... Berberine (Berberis Aristata), also known as berberine hydrochloride is a bioactive compound that can be extracted from several ...
Berberine. Berberine is a plant-based alkaloid that has been used in Ayurvedic and traditional Chinese medicine for over three ... put on berberine for a rather high A1C. The berberine plus. several daily walks put his numbers in the normal range after. four ... Berberine might slow blood clotting. Taking berberine along with medications that also slow blood clotting might increase the ... Berberine & Multiple Myeloma. My research uncovered pertinent clinical studies showing that berberine can kill human multiple ...
Study demonstrate that topical application of berberine gelatin could decrease pain intensity and promote ulcer healing with ... The aim of this trial was to investigate the efficacy and safety of berberine (an isoquinoline alkaloid originally isolated ... Tagged with: berberine, Cochrane, mouth ulcer, oral medicine and pathology, oral ulceration, recurrent aphthous stomatitis ... This appears to be the first published study that has looked at using berberine for the treatment of RAS so the effects will ...
3. Berberine: Berberine is an alkaloid from the medicinal plant, Berberis aristata. Goldenseal and coptis are other common ... Thorne Berberine caps can be given to dogs and cats based on their weight at 10mg/kg once daily for dogs or 5mg/kg/day for cats ... Much of berberines effectiveness is undoubtedly due to a combination of its direct antimicrobial activity, inhibition of ... There are numerous studies that have showed that Berberine can be more effective than antimicrobials. ...
Further studies with berberine and jatrorrhizine will be carried out to understand the mechanism involved. ... Results: C. longa consisted mainly of tannins, phenols, and flavonoids; and B. vulgaris in alkaloids. Encapsulated particles ... Methods: We tested the extracts, as well as their main constituents, curcumin (Cur) and berberine (Ber), both non-encapsulated ... Berberine and jatrorrhizine were present in the active fractions, and these compounds may be responsible for the antiparasitic ...
The berberine :. Berberine is a powerful alkaloid found in a plant called barberry. It is widely used in Chinese medicine. It ... Berberine acts on the triglycides, and allows to soothe the symptoms of colitis, and even of functional colopathy. ... Associated with berberine, glutamine also acts against gluten intolerance.. ... Able to regenerate the intestinal epithelium, berberine is even used in some medicines. ...
Some of the health-promoting compounds found in Tinospora cordifolia include alkaloids, flavonoids, and polysaccharides. These ... Some of the major chemical constituents of Tinospora cordifolia include berberine, palmatine, magnoflorine, columbin, ... Tinospora Cordifolia contains several active constituents such as alkaloids, diterpenoid lactones, glycosides, steroids, and ... Some of the key bioactive compounds include berberine, giloin, gilosterol, and cordifolioside A. ...
The natural plant alkaloid berberine enhances the expression and function of insulin receptors.1,2. • Berberine HCl is derived ... Provides 350 mg berberine HCl per capsule. • Made with high-quality, vegan ingredients backed by verifiable science. These ...
Berberine is extracted from plants and is a naturally occurring alkaloid, and is also excited photochemically. Using three ... In this study, the authors investigate the antimicrobial effects of berberine and berberine analogs. ... Strain-specific and photochemically-activated antimicrobial activity of berberine and two analogs ...
Berberine Hcl Extract and Naringin Powder . offered by Herbo Nutra, Greater Noida, Uttar Pradesh. ... Berberine is a nucleic acid binding isoquinolone alkaloid with wide potential therapeutic properties. ... Berberine is a component of some eye drop formulations.[citation needed] There is some evidence it is useful in the treatment ... Berberine is considered antibiotic. When applied in vitro and in combination with methoxyhydnocarpin, an inhibitor of multidrug ...
Berberine is a quaternary ammonium salt from the protoberberine group of benzylisoquinoline alkaloids found in such plants as ... As a natural dye, berberine has a color index of 75160.. People most commonly use berberine for diabetes, high levels of ... phellodendorine with berberine found within the leaves. The indole alkaloid has also been found in the roots of the young ... Under ultraviolet light, berberine shows a strong yellow fluorescence, making it useful in histology for staining heparin in ...
  • Berberine is an isoquinoline alkaloid extracted from the rhizomes of Ranunculaceae coptis or Cortex phellodendri . (hindawi.com)
  • Each Serving Size (1 Tablet) contains: Calcium 26 mg, Phellodendron 20:1 extract 440 mg (from Phellodendron amurense stem bark 8.8 g, Containing berberine 200 mg). (acuatlanta.net)
  • The major chemical constituents of its bark are the isoquinoline alkaloids, palmatine, jatrorrhizine, phellodendorine with berberine found within the leaves. (naturalalchemy.com.au)
  • Berberine content in the stem bark of commercial samples of C. fenestraurn purchased from the markets in Pettah was higher than those grown in Sri lanka. (who.int)
  • For centuries, people have collected the rhizomes, which contain berberine and other alkaloids, to treat a variety of symptoms. (leavesforwildlife.com)
  • While the precise mechanism of action and the extent of effectiveness for this herb remain unclear, it has been observed that the combined constituents of the herb exhibit a more potent antibacterial activity compared to berberine alone. (herbtobody.com)
  • 2015). Efficacy of berberine in patients with non-alcoholic fatty liver disease. (pno.ca)
  • 2017). Efficacy of berberine alone and in combination for the treatment of hyperlipidemia: A systematic review. (pno.ca)
  • Berberine (BBR) is a bioactive alkaloid which can be isolated from several Chinese herbs, such as Hydrastis canadensis , Berberis aristata , Coptis chinensis , Coptis japonica , Phellondendron amurense and Phellondendron chinense Schneid 1 - 3 . (scialert.net)
  • Berberine (Berberis Aristata), also known as berberine hydrochloride is a bioactive compound that can be extracted from several different plants, including a group of shrubs called Berberis , and a wide variety of herbs including goldenseal, barberry, goldthread, Oregon grape and turmeric. (herbssra.com)
  • Berberine is the main active compound of different herbs and is defined as an isoquinoline quaternary botanical alkaloid found in barks and roots of numerous plants. (nih.gov)
  • The aims of this study was to bioscreen and compare the in vitro biological activity (antioxidant, cholinergic, antidaibetic and the anticancer) of barberry crude extract and berberine active compound. (springer.com)
  • The effect of B. vulgaris extract and berberine chloride on cellular thiobarbituric acid reactive species (TBARS) formation, diphenyle-α-picrylhydrazyl (DPPH) oxidation, cellular nitric oxide (NO) radical scavenging capability, superoxide dismutase (SOD), glutathione peroxidase (GPx), acetylcholinesterase (AChE) and α-gulcosidase activities were spectrophotometrically determined. (springer.com)
  • On the other hand, the effect of extract and berberine as anticancer was estimated on three different cell lines which were MCF-7, HepG-2, and Caco-2 cells by using neutral red uptake assay which compared with control normal cells (PBMC). (springer.com)
  • Our results showed that barberry crude extract contains 0.6 mg berberine/mg crude extract. (springer.com)
  • Inhibitory effect of berberis crude extract on α-glucosidase was more potent than that of berberine chloride, while both had the same AChE inhibitory effect. (springer.com)
  • Besides, different concentrations of both berberine chloride and barberry ethanolic extract showed to have no growth inhibitory effect on normal blood cells (PBMC). (springer.com)
  • Otherwise, both berberine chloride and barberry ethanolic extract showed to have inhibitory effect on the growth of breast, liver and colon cancer cell lines (MCF7, HepG2 and CACO-2, respectively) at different incubation times starting from 24 hrs up to 72 hrs and the inhibitory effect increased with time in a dose dependant manner. (springer.com)
  • This work demonstrates the potential of the barberry crude extract and its active alkaloid, berberine, on suppressing lipid peroxidation, suggesting a promising use in the treatment of hepatic oxidative stress, Alzheimer and idiopathic male factor infertility. (springer.com)
  • Berberine from Preferred Nutrition is a concentrated barberry root extract used to support healthy glucose metabolism and cardiovascular health in adults. (pno.ca)
  • This extract has a confirmed 98% Berberine. (naturalalchemy.com.au)
  • A review of the effects of Berberis vulgaris and its major component, berberine, in metabolic syndrome. (pno.ca)
  • Caseiniurn fenestraturn (Menispermaceae) is the plant which serves as the source of berberine in Sri Lanka in place of Berberis aristata (Berberidaceae) which is very rare in Sri Lanka but common in India. (who.int)
  • 2013). Effects of berberine on lipid profile in subjects with low cardiovascular risk. (pno.ca)
  • This study indicates that C. fenestraum has a higher berberine content than B. aristata found in Sri Lanka. (who.int)
  • Berberine is an alkaloid that occurs naturally in certain medicinal plants. (pno.ca)
  • However, it is established that the herb's medicinal effects are primarily attributed to the presence of isoquinoline alkaloids. (herbtobody.com)
  • People on oral diabetes drugs should monitor blood glucose levels if taking berberine since berberine by itself will decrease blood glucose levels. (drdanenberg.com)
  • Berberine consists of nitrogen--containing substances which have been used to support immune function as well as to reduce inflammation, infection, high blood sugar, gut dysfunction, cholesterol, and triglycerides. (drdanenberg.com)
  • The tree has both antibiotic and antimicrobial properties due to the alkaloids contained within the plant material. (naturalalchemy.com.au)
  • 2012). Berberine improves insulin sensitivity by inhibiting fat stores and adjusting adipokines profile in human preadipocyte and metabolic syndrome patients. (pno.ca)
  • This review describes the role of berberine and its metabolic effects. (nih.gov)
  • The present study findings demonstrate that the topical application of berberine gelatin could decrease pain intensity and promote ulcer healing with minimal safety concerns. (nationalelfservice.net)
  • It belongs to a class of compounds called alkaloids. (herbssra.com)
  • Quinolizidine and isoquinoline are a widely distributed, heterogeneous group of alkaloids with members of each group having known toxicity to humans and domestic animals. (medscape.com)
  • In addition, berberine produces significant inhibition of CYP3A enzymes in humans. (drdanenberg.com)
  • Not only does it contain berberine, but it solves two problems at once by removing an invasive plant and leaving goldenseal to multiply. (leavesforwildlife.com)
  • Berberine Active contains Phellodendron used traditionally to support healthy liver and bowel function. (acuatlanta.net)
  • Berberine Active is standardized to contain 200 mg of berberine, the main active constituent of phellodendron which is an alkaloid of the isoquinoline group to ensure optimal strength and quality. (acuatlanta.net)
  • This alkaloid is found in roughly 500 species of plants. (drdanenberg.com)
  • Berberine content in the two plants were- determined by HPLC. (who.int)
  • Literature analysis shows that berberine affects many biochemical and pharmacological pathways that theoretically yield a positive effect on health and disease. (nih.gov)
  • These scientists are uncovering the powerful effects that berberine plays in many pathways of the body including acute diarrhea, irritable bowel syndrome, type 2 diabetes, high blood pressure, Alzheimer's disease, and cancer. (drdanenberg.com)
  • Berberine prevents cancer cell proliferation by inducing apoptosis and controlling the cell cycle as well as autophagy. (drdanenberg.com)
  • Cytisine, a tricyclic quinolizidine alkaloid found in Baptisia, Cytisus, Laburnum , and Sophora species, has nicotinelike effects on the gastrointestinal (GI) tract and the central nervous system (CNS). (medscape.com)
  • 2019). Effects of berberine on blood glucose in patients with type 2 diabetes mellitus: a systematic literature review and a meta-analysis. (pno.ca)
  • My special interest lies in the medical studies relating to the cancer fighting effects of berberine. (drdanenberg.com)
  • This appears to be the first published study that has looked at using berberine for the treatment of RAS so the effects will need to be confirmed in other populations to see if similar positive effects can be demonstrated. (nationalelfservice.net)
  • Effects of berberine gelatin on recurrent aphthous stomatitis: a randomized, placebo-controlled, double-blind trial in a Chinese cohort. (nationalelfservice.net)
  • Berberine seems to exert synergistic effects with fluconazole even in drug-resistant C. albicans infections. (herbonutra.biz)
  • Lupinus species contain sparteine, a tetracyclic quinolizidine alkaloid, and lupinine, a bicyclical quinolizidine alkaloid. (medscape.com)
  • Lupinus species are broadly divided into bitter lupins, which contain high levels of alkaloids in their seeds, and sweet lupins, which contain lower levels of alkaloids and are cultivated for human consumption. (medscape.com)
  • In one animal study [11] , berberine treatment significantly suppressed the growth of multiple myeloma tumors. (drdanenberg.com)
  • Patients were randomised to receive either the active agent ( berberine) or placebo of similar shape colour and flavour. (nationalelfservice.net)
  • Published peer-reviewed research suggests that berberine may become widely used in clinics for cancer therapy. (drdanenberg.com)
  • 2008). Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. (pno.ca)
  • People most commonly use berberine for diabetes, high levels of cholesterol or other fats in the blood, and high blood pressure. (naturalalchemy.com.au)
  • I'm not suggesting that berberine is a cure-all for disease. (drdanenberg.com)
  • Berberine possesses a bitter taste and exhibits antibacterial and amoebicidal properties. (herbtobody.com)
  • Berberine exhibits neuroprotective properties in various neurodegenerative and neuropsychological ailments. (nih.gov)
  • Here, we demonstrate that a berberine fumarate (BF) has a hypoglycemic effect by regulating the intestinal microflora and metabolism of diabetic rats. (hindawi.com)
  • These two alkaloids are also found in other genera. (medscape.com)
  • The indole alkaloid has also been found in the roots of the young dioecious trees. (naturalalchemy.com.au)
  • A 66.7% inhibition of tumor growth was noted at day 14 in the experimental group, which was treated with berberine (50 mg/kg) every other day for 2 consecutive weeks. (drdanenberg.com)
  • Berberine is a plant-based alkaloid that has been used in Ayurvedic and traditional Chinese medicine for over three thousand years. (drdanenberg.com)
  • Research shows that this alkaloid stimulates the muscles of the uterus. (herbtobody.com)
  • Under ultraviolet light, berberine shows a strong yellow fluorescence, making it useful in histology for staining heparin in mast cells. (naturalalchemy.com.au)
  • Berberine could serve as a potential candidate for the treatment of several diseases. (nih.gov)
  • Berberine is generally well tolerated at recommended dosage levels. (drdanenberg.com)
  • As a traditional medicine or dietary supplement, berberine has shown some activity against fungal infections, Candida albicans, yeast, parasites, and bacterial/viral infections. (herbonutra.biz)
  • However, the oral bioavailability of berberine is low (0.68%), and about half of the dose is not absorbed by the intestines [ 14 , 15 ]. (hindawi.com)
  • Berberine has the potential to be an anti-inflammatory and antioxidant agent as well as an effective immunomodulator. (drdanenberg.com)
  • A number of clinical studies have shown that berberine has a significant hypoglycemic effect in patients with T2D [ 13 ]. (hindawi.com)
  • Total alkaloid content in the leaves of A. cocclus (Menispermaceae) aws higher than in the stems. (who.int)
  • Berberine has a long history of use in traditional Chinese medicine, where it was used to treat various ailments. (herbssra.com)
  • In enzymology, a columbamine oxidase (EC 1.21.3.2) is an enzyme that catalyzes the chemical reaction 2 columbamine + O2 ⇌ {\displaystyle \rightleftharpoons } 2 berberine + 2 H2O Thus, the two substrates of this enzyme are columbamine and O2, whereas its two products are berberine and H2O. (wikipedia.org)
  • This time, I'm researching a chemical called berberine . (drdanenberg.com)