An alkaloid from Hydrastis canadensis L., Berberidaceae. It is also found in many other plants. It is relatively toxic parenterally, but has been used orally for various parasitic and fungal infections and as antidiarrheal.
A group of related plant alkaloids that contain the BERBERINE heterocyclic ring structure.
A plant genus of the family RANUNCULACEAE. Members contain BERBERINE and other isoquinoline ALKALOIDS.
A plant genus of the family RANUNCULACEAE. Members contain BERBERINE.

(-)-Stepholidine enhances K+ depolarization-induced activation of synaptosomal tyrosine 3-monooxygenase from rat striatum. (1/346)

AIM: To study the mechanism of K+ depolarization-induced activation of synaptosomal tyrosine 3-monooxygenase (TM) in rat striatum and the effect of (-)-stepholidine (SPD) on this activation. METHODS: The TM was assayed for DOPA by HPLC-ECD; the activities of Ca2+/calmodulin (CaM)-dependent protein kinase (PK II) and Ca2+/phosphoinositide-dependent protein kinase (PKC) were assayed using histidine as substrate. RESULTS: The incubation of striatal synaptosomes in K(+)-riched (60 mmol.L-1) medium resulted in a marked activation of TM. PKC inhibitor polymyxin B (PMB) completely blocked the activation of K+ 60 mmol.L-1 on TM. Selective D2 receptor agonist quinpirole (QP), Ca2+ removal from incubation medium and CaM antagonist W7 failed to affect the activation. However, SPD enhanced the activation of K+ 60 mmol.L-1 on TM. Meanwhile, the incubation in K+ 60 mmol.L-1 also activated PKC. Neither QP nor SPD affected K+ depolarization-induced activation of PKC. CONCLUSION: The activation of K+ depolarization on synaptosomal TM is enhanced by SPD and this activation is mediated by PKC rather than by PK II.  (+info)

Effects of berberine of L- and T-type calcium channels in guinea pig ventricular myocytes. (2/346)

AIM: To study the effects of berberine (Ber) on L-(ICa,L) and T-type (ICa,T) channels in isolated guinea pig ventricular myocytes. METHODS: Using whole cell patch-clamp recording technique. RESULTS: Ber 10, 30 mumol.L-1 inhibited the ICa, L from 1400 +/- 247 pA to 978 +/- 204 pA (n = 5 cells of 5 guinea pigs, P < 0.05), and to 664 +/- 179 pA (n = 5, P < 0.01), respectively. The inhibitory effect was concentration-dependent and non-frequency-dependent. The peak value of ICa,L in the current-voltage relationship was decreased. Ber affected the inactivation kinetics of ICa,L. The half activation potential (V0.5) was shifted from -27.8 mV to -34.2 mV and the slope factor (kappa) was changed from 9.22 into 13.03. Ber did not affect the activation kinetics. Ber 10 and 30 mumol.L-1 also inhibited ICa,T (from 154 +/- 80 pA to 101 +/- 78 pA, and to 48 +/- 45 pA, n = 8 cells of 5 guinea pigs, P < 0.05). CONCLUSION: Ber possessed blocking effects on both L- and T-type calcium channels.  (+info)

Enhancement of (-)-stepholidine on protein phosphorylation of a dopamine- and cAMP-regulated phosphoprotein in denervated striatum of oxidopamine-lesioned rats. (3/346)

AIM: To study effects of (-)-stepholidine (SPD) on the phosphorylation of a dopamine- and cAMP-regulated phosphoprotein (DARPP-32) in the striatum of oxidopamine-lesioned rats. METHODS: The amount of dephospho-DARPP-32 was measured by a back-phosphorylation assay. RESULTS: In the striatum of control rats, SPD per se had no effect on the phosphorylation of DARPP-32, but it antagonized the decrease by 28% of dephospho-DARPP-32 induced by the D1 agonist SK&F-38393. In the denervated striatum of oxidopamine-lesioned rats, SPD decreased the amount of dephospho-DARPP-32 by 44%. The effect of SPD was completely counteracted by the concomitant administration of the D1 antagonist Sch-23390. CONCLUSION: SPD exhibits D1 agonistic action on DARPP-32 phosphorylation in the denervated striatum of oxidopamine-lesioned rats, but it acts as a D1 antagonist in normal striatum.  (+info)

Differential inhibitory effects of protoberberines on sterol and chitin biosyntheses in Candida albicans. (4/346)

The anti-Candida potentials of 12 Korean medicinal plants were explored: methanol extracts from Coptis rhizoma and Phellodendron amurense caused significant inhibition of growth of Candida albicans, Candida glabrata, Candida krusei and Candida parapsilosis. The predominant active components of the extracts were the protoberberines berberine and palmatine; the most potent inhibition of growth was exhibited by berberine on C. krusei (MIC <4 mg/L) and palmatine on C. parapsilosis (MIC 16 mg/L). Both berberine and palmatine inhibited the in-vivo rate of incorporation of L-[methyl-14C]methionine into C-24 of ergosterol in C. albicans (50% inhibition concentration (IC50 values), 25 microM and 300 microM, respectively); this result suggests that sterol 24-methyl transferase (24-SMT) is one of the cellular targets for the antifungal activity of the protoberberines. In-vitro 24-SMT activity in microsomes from the yeast growth form of C. albicans was inhibited by both berberine (inhibition constant (Ki) 232 microM) and palmatine (Ki 257 microM) in a non-competitive manner; inhibition of 24-SMT was more marked for the mycelial form than for the yeast growth form of this organism. Palmatine inhibited chitin synthase from both the yeast and mycelial growth phases of C. albicans in a non-competitive manner (Ki 780 microM). The effects of protoberberines, extracted from established medicinal plants, on both sterol and cell wall biosyntheses in pathogenic fungi indicate that the potential of these compounds, or their semi-synthetic derivatives, as a novel class of antifungal agents should be investigated more fully.  (+info)

p-Chlorobenzyltetrahydroberberine inhibits vascular smooth muscle contractions caused by Ca2+. (5/346)

AIM: To investigate influences of p-chlorobenzyltetrahydroberberine (CPU-86017) and levothyroxin (Lev) on vascular smooth muscle (VSM) contractions by intracellular Ca2+ release and calcium entry. METHODS: Three kinds of contractions of rat thoracic aortic rings were used to compare suppression by CPU-86017, bepridil (Bep), verapamil (Ver), and nimodipine (Nim) in euthyroid- and Lev-induced hyperthyroidism rats. RESULTS: The IC50 of CPU-86017 on KCl-induced contractions of euthyroid and hyperthyroid VSM were 80 (36-179) and 121 (62-236) mumol.L-1, respectively. The potency of CPU-86017 was approximate to 1/10 of Bep and 1/100 of Ver and Nim. Suppressions of Ver and Nim on hyperthyroid VSM in Ca(2+)-free solution were greatly attenuated by -86% and -95%, respectively. Slight or no change in activity of CPU-86017 and Bep was found. Contractions on adding Ca2+ into Ca(2+)-free medium were suppressed by CPU-86017 and its potencies in euthyroid and hyperthyroid rats were not different. CONCLUSION: CPU-86017 is more potent to suppress Ca2+ entry than intracellular calcium mobilization and Lev enhances both.  (+info)

Effect of tetrahydropalmatine analogs on Fos expression induced by formalin-pain. (6/346)

AIM: To study the effect of tetrahydropalmatine (THP) analogs on Fos protein expression induced by formalin-pain and elucidate analgesic mechanism of THP analogs. METHODS: The pain response to Sprague Dawley rats was induced with formalin injected s.c. into the plantar surface of the right hindpaw. Fos protein expression in brain and spinal cord was investigated with immunohistochemistry. The numbers of Fos-like immunoreactive (FLI) neurons were counted with Leica Q570 image analyzer. RESULTS: In the groups of THP analogs and D2 antagonist spiperone, FLI neurons induced by intraperitoneal (i.p.) injection of THP analogs and spiperone were mainly located in the striatum and accumbens nucleus, and a few FLI neurons were also in sensorimotor cortex. In the D1 antagonist, D1 agonist, D2 agonist, saline and vehicle groups, FLI neurons were seldom seen in the striatum and accumbens nucleus. Moreover, the Fos protein expression induced by l-THP and spiperone could be prevented by the pre-treatment of the D2 agonist quinpirole but not D1 agonist SKF38393. In the formalin-pain group, FLI neurons were mainly distributed in ascending pain afferent system (APAS) and descending pain modulation system (DPMS). Following i.p. THP analogs, however, the numbers of FLI neurons induced by formalin-pain in the APAS, such as dorsal horn (mainly laminae I, II, IV-VI) were markedly decreased, while the numbers of FLI neurons in the DPMS, such as periaqueductal gray (PAG) and reticular paragigantocellular lateral nucleus (RPLN) were significantly increased. CONCLUSION: THP analogs enhanced the activity of brainstem DPMS by the blockade of D2 receptors in the striatum and accumbens nucleus, and sequentially inhibited the inputs of peripheral pain afferent message in spinal cord level.  (+info)

Berberine modulates expression of mdr1 gene product and the responses of digestive track cancer cells to Paclitaxel. (7/346)

Berberine is the major constituent of Coptis chinese and is commonly used in Chinese herbal medicine to treat patients with gastrointestinal disorders. In this study, using flow cytometry, we have found that a 24-h berberine treatment up-regulated the multidrug-resistant transporter (pgp-170) expression in two oral (KB, OC2), two gastric (SC-M1, NUGC-3) and two colon (COLO 205, CT 26) cancer cell lines. Decreased retention of rhodamine 123 was observed in berberine-treated cells as compared to vehicle control. To examine whether the berberine modulated pgp-170 expression in cancer cells is associated with changes in drug resistance, we determined the cytotoxicity, cell cycle progression and cell morphology of Paclitaxel-treated cells. Paclitaxel (1 nM-10 microM) treatment for 24 h induced cytotoxicity in OC2, SC-M1 and COLO 205 cells in a dose-dependent manner. Pretreatment of cells with 32 microM berberine for 24 h prior to Paclitaxel treatment resulted in increased viability as compared to that of Paclitaxel-treated cells. In addition, Paclitaxel-induced apoptosis and/or G2/M arrest in these three cancer cell lines. Pretreatment of cells with berberine prior to Paclitaxel blocked the Paclitaxel-induced cell cycle responses and morphological changes. These results together suggest that berberine modulated the expression and function of pgp-170 that leads to reduced response to Paclitaxel in digestive track cancer cells.  (+info)

Inhibition of Candida rugosa lipase by berberine and structurally related alkaloids, evaluated by high-performance liquid chromatography. (8/346)

It is known that certain microorganisms produce extracellular lipase to better colonize the skin and mucosal surfaces. Since different extracts from medicinal plants have anti-lipase activity (Shimura et al., Biosci. Biotechnol. Biochem., 56: 1478-1479, 1992), we examined the effects of selected natural substances on Candida rugosa lipase. In the presence of the compounds under examination, the enzyme was incubated with beta-naphthyl laurate, and beta-naphthol, produced by the enzymatic reaction, was extracted with ethyl acetate and analyzed by reversed phase HPLC, using a C-18 column. Thus, the inhibitory activity was calculated by a proper formula based on the variations of the area under the chromatographic peak of beta-naphthol. The method was validated by analyzing substances with known anti-lipase activity such as saturated fatty acids (C10-16) and tetracycline. Berberine and a number of structurally related alkaloids such as chelidonine, chelerythrine, and sanguinarine appeared active. This property of berberine and sanguinarine is of interest because they are used in pathological conditions in which microbial lipases could play a pathogenic role.  (+info)

Berberine is a chemical found in several plants including European barberry, goldenseal, goldthread, Oregon grape, phellodendron, and tree turmeric. It has a yellow color and has been used in traditional medicine for various purposes such as treating diarrhea, reducing inflammation, and fighting bacteria.

Berberine has been studied for its potential health benefits, including its ability to lower blood sugar levels, reduce cholesterol and triglycerides, and improve cardiovascular health. It is thought to work by activating AMP-activated protein kinase (AMPK), an enzyme that plays a role in regulating metabolism.

However, more research is needed to fully understand the potential benefits and risks of berberine, and it should not be used as a substitute for medical treatment. As with any supplement, it's important to talk to your doctor before taking berberine or any other herbal remedy.

Berberine alkaloids are a type of natural compound found in several plants, including the Berberis species (such as barberry and tree turmeric), goldenseal, Oregon grape, and phellodendron. The most well-known and researched berberine alkaloid is berberine itself, which has a yellow color and is commonly used in traditional medicine for various purposes, such as treating diarrhea, reducing inflammation, and combating bacterial and fungal infections.

Berberine alkaloids have a complex chemical structure that includes a nitrogen atom, making them basic in nature. They are known to interact with several biological targets, including enzymes and receptors, which contributes to their diverse pharmacological activities. Some of the key mechanisms of action of berberine alkaloids include:

1. Inhibition of DNA gyrase: Berberine alkaloids can interfere with bacterial DNA replication by inhibiting the activity of DNA gyrase, an enzyme that helps to unwind and supercoil DNA during replication. This makes them effective against a wide range of bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE).
2. Interaction with cell membranes: Berberine alkaloids can interact with the lipid bilayer of cell membranes, disrupting their integrity and increasing permeability. This can lead to the death of bacteria, fungi, and cancer cells.
3. Modulation of gene expression: Berberine has been shown to regulate the expression of various genes involved in metabolic processes, inflammation, and cell growth. For example, it can activate AMP-activated protein kinase (AMPK), a key enzyme that regulates energy metabolism, which may contribute to its potential benefits in treating diabetes, obesity, and nonalcoholic fatty liver disease.
4. Inhibition of inflammatory mediators: Berberine alkaloids can inhibit the production of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6), which are involved in the development of various inflammatory diseases.
5. Antioxidant activity: Berberine alkaloids have antioxidant properties, which can help protect cells from damage caused by reactive oxygen species (ROS). This may contribute to their potential benefits in treating neurodegenerative disorders and cancer.

In summary, berberine alkaloids exhibit a wide range of pharmacological activities, including antibacterial, antifungal, anti-inflammatory, antioxidant, and metabolic regulatory effects. These properties make them promising candidates for the development of new therapeutic agents to treat various diseases, such as infections, inflammation, diabetes, obesity, and cancer. However, further research is needed to fully understand their mechanisms of action and potential side effects before they can be safely and effectively used in clinical settings.

Coptis is a genus of flowering plants in the family Ranunculaceae, also known as coptis or goldthread. The name "Coptis" is derived from the Greek word "koptos," which means "cutting" or "engraved," referring to the shape of the root.

In a medical context, Coptis species, particularly Coptis chinensis and Coptis japonica, have been used in traditional Chinese medicine for centuries. The rhizomes (underground stems) of these plants contain various alkaloids, including berberine, which has been studied for its potential medicinal properties.

Berberine has been found to have antimicrobial, anti-inflammatory, and antioxidant effects, among others. It has been used in traditional medicine to treat a variety of conditions, such as gastrointestinal disorders, skin diseases, and infections. However, more research is needed to fully understand the potential benefits and risks of using Coptis or its constituents for medicinal purposes.

It's important to note that while some natural substances like berberine have shown promise in preliminary studies, they should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult with a healthcare provider before starting any new supplement regimen.

Hydrastis is the genus name for Hydrastis canadensis, also known as goldenseal. It is a perennial herb native to North America, and its roots and rhizomes have been used in traditional medicine for various purposes. The active compounds in goldenseal include alkaloids such as hydrastine, berberine, and canadine, which are believed to have antibacterial, anti-inflammatory, and astringent properties.

However, it is important to note that the use of Hydrastis and its preparations as a medicine should be under the guidance of a healthcare professional, as there may be potential risks and interactions with other medications. Additionally, overharvesting of goldenseal in the wild has led to concerns about its sustainability, so it is recommended to use cultivated sources instead.

As a natural dye, berberine has a color index of 75160. There is poor-quality evidence that berberine might help with various ... Berberine is classified as a traditional Chinese medicine. The Merck Index, 14th ed., 1154. Berberine IUPAC Chemical ... 2023). "Impact of Berberine or Berberine Combination Products on Lipoprotein, Triglyceride and Biological Safety Marker ... A 2023 review study said that berberine can provide a modest positive impact on lipid concentrations. Berberine weakly inhibits ...
... (EC 1.5.1.31) is an enzyme that catalyzes the chemical reaction (R)-canadine + 2 NADP+ ⇌ {\displaystyle \ ... rightleftharpoons } berberine + 2 NADPH + H+ Thus, the two substrates of this enzyme are (R)-canadine and nicotinamide adenine ... dinucleotide phosphate ion, whereas its 3 products are berberine, nicotinamide adenine dinucleotide phosphate, and hydrogen ion ...
"Berberine". WebMD. (CS1 errors: periodical ignored, Articles with short description, Short description is different from ... The root bark contains the bitter alkaloid berberine, which has been studied for its potential pharmacological properties. " ...
Berberine bridge enzyme (BBE) is a central enzyme in the biosynthesis of berberine, a pharmaceutically important alkaloid. The ... On the other hand, berberine is highly regarded for its interactions with several diseases. Berberine has been known to ... Berberine bridge enzyme-like (BBE-like enzymes) form a subgroup of the superfamily of FAD-linked oxidases (SCOPe d.58.32), ... The product of this reaction is the C-C bond and is referred to as the berberine bridge. Also, marks a branch point in the ...
The plant also contains berberine. All parts of the plant contain an irritant oil that is most concentrated within the roots ...
Berberine Jatrorrhizine Phellodendrine Yang, Seong Baek; Kim, Eun Hee; Kim, Seung Hee; Kim, Young Hun; Oh, Weontae; Lee, Jin- ... "Synthesis and Cytotoxicity Evaluation of 13-n-Alkyl Berberine and Palmatine Analogues as Anticancer Agents". Molecules. 17 (10 ...
The name is derived from berberine. Berberonic acid is obtained in the oxidation of berberine with nitric acid. It can also be ...
DiNicolantonio JJ, McCarty MF, Assanga SI, Lujan LL, O'Keefe JH (March 2022). "Ferulic acid and berberine, via Sirt1 and AMPK, ... June 2017). "Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem ... AMPK activators include resveratrol and berberine. Many such nutraceuticals are also potent antioxidants. Like prolongevity- ...
Berberine inactivates PPARγ.[citation needed] Other natural compounds from different chemical classes activate or inactivate ...
These natural products include berberine and morphine. "4-Hydroxyphenylacetaldehyde". PubChem Compound. U.S. National Library ...
This argemone resin contains berberine and protopine. The seeds resemble the seeds of Brassica nigra (mustard). As a result, ...
Rueffer M, Zenk MH (1985). "Berberine synthesis, the methylenedioxy group forming enzyme in berberine synthesis". Tetrahedron ... 2 berberine + 2 H2O Thus, the two substrates of this enzyme are columbamine and O2, whereas its two products are berberine and ... This enzyme is also called berberine synthase. This enzyme participates in alkaloid biosynthesis i. It employs one cofactor, ...
Because of the strong coloring quality of berberine, it has been traditionally used as a dye, especially for wool and other ... Gibbs, Peter J.; Seddon, Kenneth R. (1998). Berberine and Huangbo: Ancient Colorants and Dyes. London: British Library. ISBN ... chinensis) The rhizomes of Coptis chinensis contain the isoquinoline alkaloids berberine, palmatine, and coptisine among others ...
They are associated with a very modest increase in LDL (~5%). Choline Pycnogenol Berberine Red yeast rice is the natural source ... Koppen, Laura M.; Whitaker, Andrea; Rosene, Audrey; Beckett, Robert D. (October 2017). "Efficacy of Berberine Alone and in ... Doggrell, SA (May 2005). "Berberine--a novel approach to cholesterol lowering". Expert Opinion on Investigational Drugs. 14 (5 ...
In rats (Rattus rattus) berberine increases 5-HTTLPR activity. Heils A, Teufel A, Petri S, Seemann M, Bengel D, Balling U, ... Hu, Y.; Ehli, E. A.; Hudziak, J. J.; Davies, G. E. (2011). "Berberine and evodiamine influence serotonin transporter (5-HTT) ... Ahmed, Touqeer; Gilani, Anwar; Abdollahi, Mohammad; Daglia, Maria; Nabavi, Seyed; Nabavi, Mohammad (2015). "Berberine and ...
Wang, Ye; Liu, Yanfang; Du, Xinyang; Ma, Hong; Yao, Jing (30 January 2020). "The Anti-Cancer Mechanisms of Berberine: A Review ... Guamán Ortiz, Luis Miguel; Lombardi, Paolo; Tillhon, Micol; Scovassi, Anna Ivana (August 2014). "Berberine, an Epiphany Against ... Vlavcheski, Filip; O'Neill, Eric J.; Gagacev, Filip; Tsiani, Evangelia (January 2022). "Effects of Berberine against ... "Berberine: A novel therapeutic strategy for cancer". IUBMB Life. 72 (10): 2065-2079. doi:10.1002/iub.2350. ISSN 1521-6543. PMID ...
The safety of using berberine for any condition is not adequately defined by high-quality clinical research. Its potential for ... The chemical constituents include isoquinolone alkaloids, especially berberine. A full list of phytochemicals was compiled and ... doi:10.4103/0973-7847.125517 "Berberine: MedlinePlus Supplements". MedlinePlus, National Library of Medicine, US National ...
Lin S, Tsai SC, Lee CC, Wang BW, Liou JY, Shyu KG (September 2004). "Berberine inhibits HIF-1alpha expression via enhanced ...
The alkaloid berberine upregulates the expression of HNF4A. This gene also plays a pivotal role in the expression and synthesis ... Wang ZQ, Lu FE, Leng SH, Fang XS, Chen G, Wang ZS, Dong LP, Yan ZQ (Oct 2008). "Facilitating effects of berberine on rat ...
Wild plants include Fritillaria, Cordyceps, berberine and lotus. Nyêmo was the birthplace of the great translator Vairocana, ...
Anti inflammatory activity of biotransformed derivatives of berberine. For the discovery of 'Phormidin' an inhibitor of the ...
... berberine bridge enzyme, berberine-bridge-forming enzyme, and tetrahydroprotoberberine synthase. This enzyme participates in ... doi:10.1016/S0040-4039(01)80070-8. Dittrich H, Kutchan TM (1991). "Molecular cloning, expression, and induction of berberine ... Kutchan TM, Dittrich H (1995). "Characterization and mechanism of the berberine bridge enzyme, a covalently flavinylated ... alkaloid biosynthesis i. Steffens P, Nagakura N, Zenk MH (1984). "The berberine bridge forming enzyme in ...
July 2009). "Effect of berberine on Staphylococcus epidermidis biofilm formation". International Journal of Antimicrobial ...
Berberine can modulate the diversity of the gut microbiome at the dose of 500 mg/day. Forskolin increases cAMP levels. Results ... Berberine can be useful in obesity treatment and prevention through a range of mechanisms, including effects on PEPCK, the gut ... A review found that berberine can elicit clinical benefits for various diseases at standard doses and has low toxicity. The ( ... 2021). "Effects of Berberine on the Gastrointestinal Microbiota". Frontiers in Cellular and Infection Microbiology. 10: 588517 ...
It is also believed to help insomnia in Chinese herbology.[citation needed] The roots contain the bitter alkaloid berberine. ...
Berberine is the main active component of an ancient Chinese herb Coptis chinensis French, which has been administered for what ... Yin, Jun; Xing, Huili; Ye, Jianping (May 2008). "Efficacy of Berberine in Patients with Type 2 Diabetes". Metabolism. 57 (5): ... the traditional medicine berberine (from plants such as Berberis and Mahonia), caffeine (Coffea), cocaine (Coca), ephedrine ( ...
It contains, among other things, quercetin, berberine, and achyranthine. It contains the same ingredients as Sān miào wán (" ... and Berberine, a yellow dye that is known to cause brain damage in infants and severe hemolysis (destruction of red blood cells ...
... like berberine downregulate E-selectin. Study shows the adherence of Porphyromonas gingivalis to human umbilical vein ...
Gupta S, Singh N, Jaggi AS (March 2014). "Alkaloids as aldose reductase inhibitors, with special reference to berberine". ...
Some alkaloids are colored, like berberine (yellow) and sanguinarine (orange). Most alkaloids are weak bases, but some, such as ...
As a natural dye, berberine has a color index of 75160. There is poor-quality evidence that berberine might help with various ... Berberine is classified as a traditional Chinese medicine. The Merck Index, 14th ed., 1154. Berberine IUPAC Chemical ... 2023). "Impact of Berberine or Berberine Combination Products on Lipoprotein, Triglyceride and Biological Safety Marker ... A 2023 review study said that berberine can provide a modest positive impact on lipid concentrations. Berberine weakly inhibits ...
Here, we demonstrate that a berberine fumarate (BF) has a hypoglycemic effect by regulating the intestinal microflora and ... Administration of berberine fumarate significantly ameliorated the metabolic disorder; increased the populations of ... Studies have shown that berberine organic acids can reduce blood glucose and have the good effects of berberine hydrochloride [ ... Berberine is an isoquinoline alkaloid extracted from the rhizomes of Ranunculaceae coptis or Cortex phellodendri. A number of ...
Berberine is a barberry root extract used to support healthy glucose metabolism, support blood sugar balance & cardiovascular ... Berberine 500mg Vegetarian Capsules. Berberine 500mg Vegetarian Capsules Size. 90 Vegetarian CapsulesVariant sold out or ... 2013). Effects of berberine on lipid profile in subjects with low cardiovascular risk. Expert Opin Biol Ther, 13, 475-82. ... 2017). Efficacy of berberine alone and in combination for the treatment of hyperlipidemia: A systematic review. J Evid Based ...
Berberine chloride (HY-18258, purity 99.16%) was purchased from MedChemExpress (MCE, NJ, USA), Berberine hydrochloride tablets ... Durairajan S, Liu L, Lu J, Chen L, Yuan Q, Chung S, Huang L, Li X, Huang J, Li M. Berberine ameliorates β-amyloid pathology, ... Wang Y, Yan Q, Huang Z, Zou Q, Li J, Yuan M, Wu L, Cai Z. Ameliorating Ribosylation-Induced Amyloid-β Pathology by Berberine ... Zhou R, Xiang C, Cao G, Xu H, Zhang Y, Yang H, Zhang J. Berberine accelerated wound healing by restoring TrxR1/JNK in diabetes ...
Berberine (BBR) is a bioactive alkaloid which can be isolated from several Chinese herbs, such as Hydrastis canadensis, ... Effects of berberine on diabetes induced by alloxan and a high-fat/high-cholesterol diet in rats. J. Ethnopharmacol., 108: 109- ... Berberine displays antitumor activity in esophageal cancer cells in vitro. World J. Gastroenterol., 23: 2511-2518.. CrossRef ... Antitumor Ability of Berberine Accompanied by Modulation of Gut Microbiome in Sarcoma-180 Tumor-bearing Mice. International ...
Berberine could serve as a potential candidate for the treatment of several diseases. Previous literature has provided a basis ... Berberine: Pharmacological Features in Health, Disease and Aging Curr Med Chem. 2024;31(10):1214-1234. doi: 10.2174/ ... Background: Berberine is the main active compound of different herbs and is defined as an isoquinoline quaternary botanical ... Conclusion: Berberine could serve as a potential candidate for the treatment of several diseases. Previous literature has ...
Our balanced blend begins with berberine, an active alkaloid found in a variety of traditional herbals. We use pure berberine ... We supercharge berberines insulin-supporting properties with the addition of true Ceylon cinnamon (Cinnamomum verum), the only ... Looking for a glucose defense supplement you can trust that wont break the bank? Our new Berberine Complex with Cinnamon, ... This is a Brand New and Sealed Swanson Berberine Complex with Cinnamon, Gymnema & Fenugreek - 90 vcaps this has been sourced ...
Berberine is a powerful antioxidant that supports glycemic control and lipid profiles to promote healthy cholesterol & blood ... Berberine Side Effects. When taken at normal doses Berberine is non-toxic and is usually well tolerated. The most common side ... Berberine should be taken along with or directly after a meal in order to maximize its beneficial effect on blood glucose ... Berberine is an alkaloid extracted from plants with a history of usage in traditional Chinese medicine. It is most commonly ...
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A full-spectrum berberine blend that combines purified berberine alongside whole herb sources. This helps to support healthy ... Full Spectrum Berberine. Elevate your health with the power of natures treasure for heart health, Berberine. Rooted in ... A full-spectrum berberine blend that combines purified berberine alongside whole herb sources. This helps to support healthy ... We include purified berberine (from Indian Barberry) alongside extracts from naturally berberine-rich plants Coptis and Oregon ...
Berberine Berberine is a plant extract that has been used in Chinese and Ayurvedic medicine for over 2,500 years for its broad ... Berberine can be found in the roots and stems of plants such as Hydastatis canadensis (goldenseal), Coptis chinensis ( ... Berberine ALA provides multidimensional support for cardiovascular health by maintaining healthy cholesterol levels and ... The powerful combination of berberine and alpha lipoic acid (ALA) helps maintain heart function, metabolism, antioxidant status ...
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As a natural dye, berberine has a color index of 75160.. People most commonly use berberine for diabetes, high levels of ... Berberine is a quaternary ammonium salt from the protoberberine group of benzylisoquinoline alkaloids found in such plants as ... Under ultraviolet light, berberine shows a strong yellow fluorescence, making it useful in histology for staining heparin in ... Cautions: The safety of using berberine for any condition is not adequately defined by high-quality clinical research. Its ...
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  • Berberine from Preferred Nutrition is a concentrated barberry root extract used to support healthy glucose metabolism and cardiovascular health in adults. (pno.ca)
  • The aims of this study was to bioscreen and compare the in vitro biological activity (antioxidant, cholinergic, antidaibetic and the anticancer) of barberry crude extract and berberine active compound. (springer.com)
  • Our results showed that barberry crude extract contains 0.6 mg berberine/mg crude extract. (springer.com)
  • Besides, different concentrations of both berberine chloride and barberry ethanolic extract showed to have no growth inhibitory effect on normal blood cells (PBMC). (springer.com)
  • Otherwise, both berberine chloride and barberry ethanolic extract showed to have inhibitory effect on the growth of breast, liver and colon cancer cell lines (MCF7, HepG2 and CACO-2, respectively) at different incubation times starting from 24 hrs up to 72 hrs and the inhibitory effect increased with time in a dose dependant manner. (springer.com)
  • This work demonstrates the potential of the barberry crude extract and its active alkaloid, berberine, on suppressing lipid peroxidation, suggesting a promising use in the treatment of hepatic oxidative stress, Alzheimer and idiopathic male factor infertility. (springer.com)
  • We use pure berberine from the Indian barberry tree-an economical, environmentally sustainable source. (begood.ie)
  • We include 1,000mg of purified berberine from Indian Barberry. (utzy.com)
  • Berberine can be found in the roots and stems of plants such as Hydastatis canadensis (goldenseal), Coptis chinensis (goldenthread), Berberis aquifolium (Oregon grape) and Berberis vulgaris (barberry). (delawareintegrativemedicine.com)
  • Sourced from the roots and bark of Berberis aristata, commonly referred to as Indian Barberry, this berberine extract delivers 500 mg per capsule-a dosage validated by clinical studies for its efficacy. (yourhealth-simplified.com)
  • Berberine is a compound found in various plants, such as goldenseal, Oregon grape, and barberry. (fitnessgeared.com)
  • Berberine (Berberis Aristata), also known as berberine hydrochloride is a bioactive compound that can be extracted from several different plants, including a group of shrubs called Berberis , and a wide variety of herbs including goldenseal, barberry, goldthread, Oregon grape and turmeric. (herbssra.com)
  • Berberine is a bioactive compound found in various plants, including goldenseal, barberry, and Chinese goldthread. (synchronicity.health)
  • Berberine is a quaternary ammonium salt from the protoberberine group of benzylisoquinoline alkaloids Due to its yellow color, Berberis were used to dye wool, leather, and wood. (wikipedia.org)
  • The major chemical constituents of its bark are the isoquinoline alkaloids, palmatine, jatrorrhizine, phellodendorine with berberine found within the leaves. (naturalalchemy.com.au)
  • PROMOTES HEALTHY CHOLESTEROL - Berberine has been shown to promote healthy cholesterol and blood glucose levels. (theswellscore.com)
  • Berberine should be taken along with or directly after a meal in order to maximize its beneficial effect on blood glucose levels. (theswellscore.com)
  • 4] In addition to maintaining healthy lipid levels, berberine has also been shown to maintain healthy blood glucose levels and support healthy liver function. (revitamedical.com)
  • Research has shown that berberine can effectively lower blood glucose levels by improving insulin sensitivity and reducing insulin resistance. (synchronicity.health)
  • People on oral diabetes drugs should monitor blood glucose levels if taking berberine since berberine by itself will decrease blood glucose levels. (drdanenberg.com)
  • A review of the effects of Berberis vulgaris and its major component, berberine, in metabolic syndrome. (pno.ca)
  • Inhibitory effect of berberis crude extract on α-glucosidase was more potent than that of berberine chloride, while both had the same AChE inhibitory effect. (springer.com)
  • Berberine (BBR) is a bioactive alkaloid which can be isolated from several Chinese herbs, such as Hydrastis canadensis , Berberis aristata , Coptis chinensis , Coptis japonica , Phellondendron amurense and Phellondendron chinense Schneid 1 - 3 . (scialert.net)
  • Berberine Hydrochloride Hydrate, Coptis Root Extract ( Coptis chinensis ), Oregon Grape Root Extract ( Berberis aquifolium ), Hypromellose (Natural Vegetable Capsules), Magnesium Stearate, and Silicon Dioxide. (utzy.com)
  • Caseiniurn fenestraturn (Menispermaceae) is the plant which serves as the source of berberine in Sri Lanka in place of Berberis aristata (Berberidaceae) which is very rare in Sri Lanka but common in India. (who.int)
  • Literature analysis shows that berberine affects many biochemical and pharmacological pathways that theoretically yield a positive effect on health and disease. (nih.gov)
  • One of the key benefits of berberine is its ability to help manage blood sugar levels. (synchronicity.health)
  • This breakthrough ensures prolonged efficacy and maximizes the health benefits of berberine, making Slimaglutide® a leader in metabolic health support. (nutritionalsupplementshop.com)
  • Each Serving Size (1 Tablet) contains: Calcium 26 mg, Phellodendron 20:1 extract 440 mg (from Phellodendron amurense stem bark 8.8 g, Containing berberine 200 mg). (acuatlanta.net)
  • Berberine content in the stem bark of commercial samples of C. fenestraurn purchased from the markets in Pettah was higher than those grown in Sri lanka. (who.int)
  • Our capsules contain 500mg of Berberine hydroxypropyl methyl cellulose, a bioactive alkaloid found in several plants, including goldenseal, Oregon grape, and tree turmeric which Dr. David Sinclair recommends for its anti-ageing benefits. (regenwellness.com.au)
  • 2015). Efficacy of berberine in patients with non-alcoholic fatty liver disease. (pno.ca)
  • 2017). Efficacy of berberine alone and in combination for the treatment of hyperlipidemia: A systematic review. (pno.ca)
  • From managing blood sugar levels to supporting cardiovascular health and boosting immune function , berberine has proven its efficacy time and time again. (synchronicity.health)
  • A 2023 review study said that berberine can provide a modest positive impact on lipid concentrations. (wikipedia.org)
  • 2013). Effects of berberine on lipid profile in subjects with low cardiovascular risk. (pno.ca)
  • SUPPORTS CARDIOVASCULAR FUNCTION - Berberine has been shown to support and maintain glycemic control and lipid profiles. (theswellscore.com)
  • The powerful combination of berberine and alpha lipoic acid (ALA) helps maintain heart function, metabolism, antioxidant status, and lipid and glucose levels. (delawareintegrativemedicine.com)
  • The powerful combination of berberine and MegaNatural® BP (a premium grape seed extract) addresses healthy heart function, healthy blood pressure, and healthy lipid and glucose levels. (revitamedical.com)
  • Among their numerous benefits, berberine and MegaNatural® BP grape seed extract activate genes that regulate lipid and glucose utilization, support healthy liver function and aid in maintaining insulin sensitivity. (revitamedical.com)
  • Rooted in centuries of wisdom, Berberine is celebrated in both Ayurvedic and Chinese herbal traditions for its remarkable wellness benefits. (utzy.com)
  • Berberine ALA provides multidimensional support for cardiovascular health by maintaining healthy cholesterol levels and supporting blood sugar balance already within normal levels. (delawareintegrativemedicine.com)
  • Clinical trials have demonstrated that berberine administration supports cardiovascular health in a number of synergistic ways. (delawareintegrativemedicine.com)
  • Clinical trials have demonstrated that berberine administration supports cardiovascular health in a number of synergistic ways including maintaining blood pressure, supporting healthy heart contraction and rhythm and supporting healthy cholesterol levels. (revitamedical.com)
  • 3] Another recent study using 500 mg of berberine was able to reproduce similar results, confirming berberine's powerful effect on specific cardiovascular markers including LDL cholesterol, HDL cholesterol and triglyceride levels. (revitamedical.com)
  • Additionally, berberine has been shown to support cardiovascular health by lowering cholesterol levels and reducing inflammation. (fitnessgeared.com)
  • In conclusion, berberine is a powerful natural supplement that can offer a wide range of health benefits, from supporting blood sugar control to improving cardiovascular health. (fitnessgeared.com)
  • In addition to its impact on blood sugar, berberine also offers cardiovascular benefits. (synchronicity.health)
  • Berberine also supports cardiovascular health by reducing inflammation, improving blood vessel function, and protecting against oxidative stress. (synchronicity.health)
  • This study indicates that C. fenestraum has a higher berberine content than B. aristata found in Sri Lanka. (who.int)
  • Packed with the therapeutic power of berberine, this revolutionary supplement is designed to support your body's natural healing processes and promote optimal health. (synchronicity.health)
  • Berberine is an isoquinoline alkaloid extracted from the rhizomes of Ranunculaceae coptis or Cortex phellodendri . (hindawi.com)
  • Formation of the berberine bridge is rationalized as an oxidative process in which the N-methyl group, supplied by S-adenosyl methionine (SAM), is oxidized to an iminium ion, and a cyclization to the aromatic ring occurs by virtue of the phenolic group. (wikipedia.org)
  • Dietary berberine against intestinal oxidative stress, inflammation response, and microbiota disturbance caused by chronic copper exposure in freshwater grouper (Acrossocheilus fasciatus). (bvsalud.org)
  • In conclusion, berberine showed significant protective effects against Cu2+-induced intestinal oxidative stress , inflammation response, and microbiota disturbance in freshwater grouper. (bvsalud.org)
  • The effect of B. vulgaris extract and berberine chloride on cellular thiobarbituric acid reactive species (TBARS) formation, diphenyle-α-picrylhydrazyl (DPPH) oxidation, cellular nitric oxide (NO) radical scavenging capability, superoxide dismutase (SOD), glutathione peroxidase (GPx), acetylcholinesterase (AChE) and α-gulcosidase activities were spectrophotometrically determined. (springer.com)
  • On the other hand, the effect of extract and berberine as anticancer was estimated on three different cell lines which were MCF-7, HepG-2, and Caco-2 cells by using neutral red uptake assay which compared with control normal cells (PBMC). (springer.com)
  • Berberine Berberine is a plant extract that has been used in Chinese and Ayurvedic medicine for over 2,500 years for its broad range of health-promoting properties. (delawareintegrativemedicine.com)
  • This extract has a confirmed 98% Berberine. (naturalalchemy.com.au)
  • Berberine capsules are a natural and effective way to support your overall health and well-being. (regenwellness.com.au)
  • In one animal study [11] , berberine treatment significantly suppressed the growth of multiple myeloma tumors. (drdanenberg.com)
  • Berberine inclusion significantly downregulated proinflammatory factors NLR family pyrin domain containing 3 (nlrp3), interleukin 1 beta (il1ß), interleukin 6 cytokine family signal transducer (il6st) but upregulated transforming growth factor beta 1 (tgfß1) and heat shock 70 kDa protein (hsp70) expression. (bvsalud.org)
  • Moreover, berberine at both levels maintained the intestinal structural integrity and significantly improved gap junction gamma-1 (gjc1) mRNA level compared to the Cu group (P (bvsalud.org)
  • Berberine is the main active compound of different herbs and is defined as an isoquinoline quaternary botanical alkaloid found in barks and roots of numerous plants. (nih.gov)
  • Our balanced blend begins with berberine, an active alkaloid found in a variety of traditional herbals. (begood.ie)
  • Berberine Active is standardized to contain 200 mg of berberine, the main active constituent of phellodendron which is an alkaloid of the isoquinoline group to ensure optimal strength and quality. (acuatlanta.net)
  • 2019). Effects of berberine on blood glucose in patients with type 2 diabetes mellitus: a systematic literature review and a meta-analysis. (pno.ca)
  • 2008). Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. (pno.ca)
  • People most commonly use berberine for diabetes, high levels of cholesterol or other fats in the blood, and high blood pressure. (naturalalchemy.com.au)
  • Numerous studies support this, showing that berberine can effectively lower blood sugar levels and improve insulin sensitivity, which is crucial for those with diabetes or prediabetes. (fitnessgeared.com)
  • These scientists are uncovering the powerful effects that berberine plays in many pathways of the body including acute diarrhea, irritable bowel syndrome, type 2 diabetes, high blood pressure, Alzheimer's disease, and cancer. (drdanenberg.com)
  • Emerging evidence shows that in patients with diabetes, berberine can decrease fasting and postprandial glucose and hemoglobin A1C. (msdmanuals.com)
  • A meta-analysis of berberine in 28 studies (2313 subjects) compared berberine to lifestyle modifications, diabetes medication monotherapy, or berberine combined with diabetes medications. (msdmanuals.com)
  • A number of clinical studies have shown that berberine has a significant hypoglycemic effect in patients with T2D [ 13 ]. (hindawi.com)
  • Cautions: The safety of using berberine for any condition is not adequately defined by high-quality clinical research. (naturalalchemy.com.au)
  • Revtia Berberine formula backed by extensive clinical research, is designed to address several factors for optimal cardiometabolic health. (revitamedical.com)
  • 1,2] A clinical trial with 32 subjects demonstrated that administration of 500 mg of berberine given twice daily for three months helped maintain healthy LDL cholesterol and triglyceride levels, versus the control group. (revitamedical.com)
  • A full-spectrum berberine blend that combines purified berberine alongside whole herb sources. (utzy.com)
  • Look no further than Synchronicity Health's Berberine Blend. (synchronicity.health)
  • Don't let your health take a backseat - experience the power of Synchronicity Health's Berberine Blend and take control of your well-being. (synchronicity.health)
  • Slimaglutide® harnesses the power of Cyclosome® Berberine and an exclusive blend of 10 other Glucagon-like Peptide-1 (GLP-1) receptor agonists and secretagogues. (nutritionalsupplementshop.com)
  • Our new Berberine Complex with Cinnamon, Gymnema & Fenugreek delivers effective support for maintaining healthy glucose metabolism. (begood.ie)
  • With each component working together, our Berberine Complex provides comprehensive support to help you achieve and maintain healthy blood sugar levels within normal range. (begood.ie)
  • Swanson Premium Brand Berberine Complex delivers affordable, effective metabolic support. (begood.ie)
  • Berberine Complex is formulated to support the healthy balance of bacteria. (holistique.com)
  • That's why our berberine complex is carefully formulated using a synergistic combination of botanical extracts, ensuring maximum potency and bioavailability. (synchronicity.health)
  • The present study findings demonstrate that the topical application of berberine gelatin could decrease pain intensity and promote ulcer healing with minimal safety concerns. (nationalelfservice.net)
  • Introducing Nature's Body Berberine, a natural dietary supplement that provides metabolic support and promotes overall health. (regenwellness.com.au)
  • Endocrinologists are throwing cold water on TikTok's claims that the supplement berberine produces the same amount of weight loss seen with new medications like semaglutide or tirzepatide. (medscape.com)
  • 6] A study examining berberine's metabolic supporting effects found that berberine improved glucose tolerance and maintained healthy insulin levels, while helping to maintain healthy total cholesterol and triglyceride levels after four weeks of berberine administration. (revitamedical.com)
  • By taking berberine regularly, I've been able to maintain healthier cholesterol levels and reduce my risk of heart disease. (fitnessgeared.com)
  • Berberine consists of nitrogen--containing substances which have been used to support immune function as well as to reduce inflammation, infection, high blood sugar, gut dysfunction, cholesterol, and triglycerides. (drdanenberg.com)
  • 2012). Berberine improves insulin sensitivity by inhibiting fat stores and adjusting adipokines profile in human preadipocyte and metabolic syndrome patients. (pno.ca)
  • Berberine has also been shown to promote the uptake of glucose through a mechanism that does not require insulin, promoting better glucose usage within the cell. (revitamedical.com)
  • There is poor-quality evidence that berberine might help with various conditions including metabolic diseases, inflammatory markers, liver and kidney dysfunction, and gastrointestinal disorders. (wikipedia.org)
  • It is strongly recommended that each capsule of Berberine taken per day be consumed at least 3 hours after the last one, as taking too much at once can increase the likelihood of gastrointestinal side effects. (theswellscore.com)
  • Additionally, some people may experience mild side effects when starting berberine, such as gastrointestinal discomfort or nausea. (fitnessgeared.com)
  • Berberine should not be combined with any prescription medications without first consulting a physician as serious adverse reactions can occur when it is combined with certain drugs, specifically Phosphodiesterase inhibitors and microlide antibiotics. (theswellscore.com)
  • Berberine can interact with certain medications, so it's crucial to ensure it's safe for you to use. (fitnessgeared.com)
  • Taking berberine along with medications that also slow blood clotting might increase the risk of bruising and bleeding. (drdanenberg.com)
  • Taking berberine along with medications that lower blood pressure might cause blood pressure to go too low. (drdanenberg.com)
  • Taking berberine with sedative medications might cause breathing problems and/or too much sleepiness. (drdanenberg.com)
  • Berberine is a powerful antioxidant that is shown to support healthy brain function including memory and problem solving ability. (theswellscore.com)
  • Berberine has the potential to be an anti-inflammatory and antioxidant agent as well as an effective immunomodulator. (drdanenberg.com)
  • Berberine (BBR) is known for its strong antioxidant , anti-inflammatory, and capacity to preserve intestinal microbiota balance in fish. (bvsalud.org)
  • Berberine weakly inhibits the CYP2D6 and CYP3A4 enzymes which are involved in metabolism of endogenous substances and xenobiotics, including many prescription drugs. (wikipedia.org)
  • Berberine, a natural compound found in certain plants, has been used for centuries in traditional medicine for its numerous health benefits. (synchronicity.health)
  • Patients were randomised to receive either the active agent ( berberine) or placebo of similar shape colour and flavour. (nationalelfservice.net)
  • Effects of berberine gelatin on recurrent aphthous stomatitis: a randomized, placebo-controlled, double-blind trial in a Chinese cohort. (nationalelfservice.net)
  • However, the oral bioavailability of berberine is low (0.68%), and about half of the dose is not absorbed by the intestines [ 14 , 15 ]. (hindawi.com)
  • Despite its low bioavailability after oral administration, berberine is a promising tool for several disorders. (nih.gov)
  • Our proprietary Nexrutine® XS Cyclosome® Berberine showcases an unparalleled enhancement in bioavailability, overcoming traditional absorption challenges. (nutritionalsupplementshop.com)
  • Elevate your health with the power of nature's treasure for heart health , Berberine. (utzy.com)
  • can you lose weight too fast Keto Gummis Keto Gummies Oprah berberine weight loss before and after Family Health Bureau. (gov.lk)
  • And gradually calmed down after berberine weight loss before and after a long time he raised his head again my lord can the student see brother li cang chen looked at him carefully Family Health Bureau berberine weight loss before and after for a while not being able to see any flaw in his face he finally nodded and. (gov.lk)
  • First and foremost, let's talk about how berberine has helped me improve my overall health. (fitnessgeared.com)
  • Based on my experience and the research I've reviewed, berberine is definitely worth considering for anyone looking to improve their overall health and well-being. (fitnessgeared.com)
  • Berberine has been extensively studied for its wide range of health benefits. (synchronicity.health)
  • It's recommended that one 500 mg capsule of Berberine be taken between two to four times per day. (theswellscore.com)
  • Each capsule contains high-quality berberine, extracted from natural sources, ensuring you receive the best of what nature has to offer. (utzy.com)
  • Berberine is generally well tolerated at recommended dosage levels. (drdanenberg.com)
  • In addition, berberine is beneficial in the early stages of cancer development by lowering epithelial-mesenchymal transition protein expression. (drdanenberg.com)
  • This appears to be the first published study that has looked at using berberine for the treatment of RAS so the effects will need to be confirmed in other populations to see if similar positive effects can be demonstrated. (nationalelfservice.net)
  • This review describes the role of berberine and its metabolic effects. (nih.gov)
  • My special interest lies in the medical studies relating to the cancer fighting effects of berberine. (drdanenberg.com)
  • This study aimed to investigate the protective effects of berberine against copper -induced toxicity in the intestine of freshwater grouper Acrossocheilus fasciatus. (bvsalud.org)
  • Berberine Active contains Phellodendron used traditionally to support healthy liver and bowel function. (acuatlanta.net)
  • In addition, berberine produces significant inhibition of CYP3A enzymes in humans. (drdanenberg.com)
  • Here, we demonstrate that a berberine fumarate (BF) has a hypoglycemic effect by regulating the intestinal microflora and metabolism of diabetic rats. (hindawi.com)
  • Berberine content in the two plants were- determined by HPLC. (who.int)
  • Berberine is an alkaloid that occurs naturally in certain medicinal plants. (pno.ca)
  • Berberine is an alkaloid extracted from plants with a history of usage in traditional Chinese medicine. (theswellscore.com)
  • Oregon grape is a berberine-rich plant that has a long history of medicinal use among the indigenous tribes of the Pacific Northwest region of North America. (utzy.com)