ISOQUINOLINES with a benzyl substituent.

Inhibition of human immunodeficiency virus type 1 replication by combination of transcription inhibitor K-12 and other antiretroviral agents in acutely and chronically infected cells. (1/274)

8-Difluoromethoxy-1-ethyl-6-fluoro-1,4-dihydro-7-[4-(2-methoxyp hen yl)-1- piperazinyl]-4-oxoquinoline-3-carboxylic acid (K-12) has recently been identified as a potent and selective inhibitor of human immunodeficiency virus type 1 (HIV-1) transcription. In this study, we examined several combinations of K-12 and other antiretroviral agents for their inhibitory effects on HIV-1 replication in acutely and chronically infected cell cultures. Combinations of K-12 and a reverse transcriptase (RT) inhibitor, either zidovudine, lamivudine, or nevirapine, synergistically inhibited HIV-1 replication in acutely infected MT-4 cells. The combination of K-12 and the protease inhibitor nelfinavir (NFV) also synergistically inhibited HIV-1, whereas the synergism of this combination was weaker than that of the combinations with the RT inhibitors. K-12 did not enhance the cytotoxicities of RT and protease inhibitors. Synergism of the combinations was also observed in acutely infected peripheral blood mononuclear cells. The combination of K-12 and cepharanthine, a nuclear factor kappa B inhibitor, synergistically inhibited HIV-1 production in tumor necrosis factor alpha-stimulated U1 cells, a promonocytic cell line chronically infected with the virus. In contrast, additive inhibition was observed for the combination of K-12 and NFV. These results indicate that the combinations of K-12 and clinically available antiretroviral agents may have potential as chemotherapeutic modalities for the treatment of HIV-1 infection.  (+info)

Effects of dauricine, quinidine, and sotalol on action potential duration of papillary muscles in vitro. (2/274)

AIM: To compare the characteristics of dauricine, sotalol, and quinidine on action potential duration (APD). METHODS: Using intracellular microelectrode method to record APD in guinea pig papillary muscles. RESULTS: Dauricine 20 mumol.L-1 prolonged action potential at 90% repolarization, the percent of APD prolongation were 22 +/- 8, 11 +/- 6, 9 +/- 5, 7 +/- 5, 6 +/- 3, 4.3 +/- 2.8, 4.5 +/- 2.8 at the cycle lengths of 200-2000 ms, dauricine became more effective in lengthening APD at short cycle lengths. The effect of dauricine on prolonging APD exhibited normal use-dependence, whereas quinidine 1 mumol.L-1 and sotalol 10 mumol.L-1 were less effective in lengthening APD at short cycle lengths. The effect of quinidine and sotalol on APD exhibited reverse use-dependence. CONCLUSSION: The effect of dauricine on APD depends on activation frequency.  (+info)

Effect of tetrandrine on proto-oncogene c-fos expression in rat cerebrum. (3/274)

AIM: To detect the effect of tetrandrine (Tet) on c-fos gene expression in cerebrum induced by lindane, a neurotoxicant which activates Ca2+ channels. METHODS: Northern and dot blotting, dual wavelength thin layer chromatography scanner, were used in this study. RESULTS: Lindane 30 mg.kg-1 given by intragastric gavage (i.g.) increased the expression of c-fos gene to 146 mm2 in rat cerebrum 1 h after treatment. Tet 1, 2, and 4 mg.kg-1 given by i.g. 30 min prior to lindane reduced c-fos gene expression in a concentration-dependent manner. Expressed genes reached only 86, 40, and 39 mm2, respectively. CONCLUSION: Tet inhibited c-fos gene expression in rat cerebrum induced by Ca2+ agonist-lindane.  (+info)

Stimulation of pregnant rat uterine contraction by the polychlorinated biphenyl (PCB) mixture aroclor 1242 may be mediated by arachidonic acid release through activation of phospholipase A2 enzymes. (4/274)

The polychlorinated biphenyl (PCB) mixture Aroclor 1242 (A1242) increases frequency of contractions of pregnant rat uteri, suggesting a possible mechanism for decreased gestational age and increased spontaneous abortion in women and animals exposed to PCBs. In the present study, we hypothesized that A1242-induced stimulation of uterine contraction is mediated by arachidonic acid released by phospholipase A2 (PLA2) enzymes. Isometric uterine contraction was measured in longitudinal uterine strips isolated from gestation day 10 rat. Pretreatment of uterine strips with the PLA2 inhibitor (E)-6-(bromomethylene)tetrahydro-3-(1-naphthalenyl)-2H-pyran-2-one (HELSS) or manoalide, or an inhibitor of the G protein of PLA2, isotetrandrine, completely prevented the increase of contractile frequency induced by 50 microM A1242. However, the phospholipase C inhibitors 2-nitro-4-carboxyphenyl-N,N-diphenylcarbamate (NCDC) and neomycin were unable to block stimulation of uterine contraction by A1242. In accordance, A1242 (100 microM) did not release inositol phosphates from myo-[3H]inositol-labeled myometrial cells, whereas myometrial cells prelabeled with [3H]arachidonic acid released arachidonic acid in a concentration- and time-dependent manner after exposure to A1242 (10-100 microM). A1242 significantly stimulated arachidonic acid release in the absence of extracellular calcium, although the release was attenuated. Analysis of the eicosanoids released by A1242 indicated that only 0.83% of released [3H]arachidonic acid was metabolized to eicosanoids and 99.07% remained as free arachidonate. Uterine contraction increased in strips exposed to exogenous arachidonic acid (1-100 microM). This study suggests that A1242 stimulates contraction in pregnant rat uterus by a mechanism involving PLA2-mediated arachidonic acid release, and that arachidonic acid, rather than eicosanoids, may mediate A1242 uterotonic action in the uterus.  (+info)

Tetrandrine inhibited chronic "inflammatory" pulmonary hypertension in rats. (5/274)

AIM: To study the effects of tetrandrine (Tet), on pulmonary hypertension. METHODS: An "inflammatory" chronic pulmonary hypertension induced by monocrotaline (Mon) in rats was used. RESULTS: Tet 50, 100, and 150 mg.kg-1.d-1 i.g. 3 wk inhibited Mon-induced increase of pulmonary artery pressure (PAP) by 23.8%, 34.9% (P < 0.05), and 42.0%, (P < 0.05); the right heart index by 2.0%, 25.0%, and 30.0% (P < 0.05) respectively compared with those from Mon group, without significant influence on the systemic artery pressure (SAP). Using histological exam by Verhoeff elastic stain and computer scanning analysis, it was found that Tet (100 mg.kg-1.d-1) for 3 wk, inhibited the increase of medial thickness and cross sectional area by 57.8% (P < 0.01) and 54.6% (P < 0.01), respectively vs Mon group. CONCLUSION: Tet ameliorated the development of pulmonary vascular and lung tissue injury induced by Mon in rats.  (+info)

Dauricine inhibited L-type calcium current in single cardiomyocyte of guinea pig. (6/274)

AIM: To study the effect of dauricine (Dau) on L-type calcium current in guinea pig ventricular myocytes. METHODS: Using whole-cell recording method to record L-type calcium current (ICa) in single ventricular cell of guinea pig. RESULTS: Dau 1, 10, and 100 mumol.L-1 markedly reduced ICa by 15.2% +/- 2.2%, 41% +/- 5%, and 82% +/- 8%, respectively. After washing out, ICa partially recovered. Dau inhibited ICa at 3 Hz and 1 Hz to a similar extent, its effect on ICa appeared to be not frequency-dependent. CONCLUSION: Dau had a calcium channel blocking effect.  (+info)

Effects of anti-rheumatic herbal medicines on cellular adhesion molecules. (7/274)

OBJECTIVE: To test the hypothesis whether herbal medicines ameliorate inflammatory diseases via the modulation of cellular adhesion molecules (CAMs). METHODS: Human neutrophils, synovial fibroblasts, and endothelial cells were incubated with different concentrations of Tripterygium Wilfordii Hook-f (TWH-f) or Tetrandrine in the presence or absence of interleukin 1 (IL1). The amount of soluble E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cellular adhesion molecule-1 (VCAM-1) secreted by cells were determined by ELISA. The cell surface expression of these three CAMs was detected by flow cytometry. RESULTS: TWH-f at high concentration (50 ng/ml) has a significant (p<0.05) inhibitory effect on both the secretion and the expression of the cellular adhesion molecules. However, Tetrandrine did not demonstrate the same effects. CONCLUSIONS: The cellular adhesion molecules of the endothelium and leucocytes may constitute excellent targets for the development of new anti-inflammation medicines. These results indicate that TWH could be a potential therapeutic agent in the treatment of inflammatory diseases.  (+info)

Effects of N-methyl berbamine on delayed outward potassium current in isolated rat hepatocytes. (8/274)

AIM: To study the effects of N-methyl berbamine (NMB) on the delayed outward potassium currents (Ik) in isolated rat hepatocytes. METHODS: With patch-clamp techniques and whole-cell recording method, holding potential -50 mV, command potential +30 to +140 mV, duration 900 ms. RESULTS: NMB reduced Ik in a concentration-dependent manner. When the concentrations of NMB were 20, 50, 400 nmol.L-1 and 50 mumol.L-1, the amplitude values of Ik were decreased to 3.6 +/- 0.4 (P > 0.05), 2.1 +/- 1.6 (P > 0.05), 3.7 +/- 1.6 (P < 0.05), 2.3 +/- 1.3 nA (P < 0.01) from 4.4 +/- 1.0 (n = 4), 2.5 +/- 1.8 (n = 4), 5.8 +/- 2.1 (n = 5), 4.6 +/- 1.3 (n = 6) nA of control, respectively. The inhibitory rates were 10%, 15%, 37%, and 51%, respectively. CONCLUSION: NMB was a K+ channel inhibitor.  (+info)

Tetrandrine a bis-benzylisoquinoline alkaloid, is a calcium channel blocker. It has anti-inflammatory, immunologic and antiallergenic effects. It inhibits the degranulation of mast cells. It has a quinidine-like anti-arrhythmic effect. It has been isolated from Stephania tetrandra S Moore, and other Chinese and Japanese herbs. It has vasodilatory properties and can therefore reduce blood pressure. Tetrandrine may have potential use for the treatment of liver disease and liver cancer. Tetrandrine has potential therapeutic value to prevent excess scarring/fibrosis in conjunctiva following trabeculectomy or in patients with severe conjunctival inflammation. Tetrandrine has anti-inflammatory and anti-fibrogenic actions, which make tetrandrine and related compounds potentially useful in the treatment of lung silicosis, liver cirrhosis, and rheumatoid arthritis. Tetrandrine has also been shown to inhibit entry of Ebola virus into host cells in vitro and showed therapeutic efficacy against Ebola in ...
Benzylisoquinoline is the structural backbone of many alkaloids with a wide variety of structures including papaverine, noscapine, codeine, morphine, apomorphine, berberine, protopine and tubocurarine. Many benzylisoquinoline alkaloids have been reported to show therapeutic properties and to act as novel medicines. Thus it is important to collect and compile benzylisoquinoline alkaloids in order to explore their usage in medicine. We extract information about benzylisoquinoline alkaloids from various sources like PubChem, KEGG, KNApSAcK and manual curation from literature. This information was processed and compiled in order to create a comprehensive database of benzylisoquinoline alkaloids, called BIAdb. The current version of BIAdb contains information about 846 unique benzylisoquinoline alkaloids, with multiple entries in term of source, function leads to total number of 2504 records. One of the major features of this database is that it provides data about 627 different plant species as a source of
Tetrandrine, an alkaloid isolated from the Chinese herb, Radix stephaniae tetrandrae, has been used clinically as a hypotensive agent for a long time. Recently, several studies have demonstrated that tetrandrine behaves like a calcium entry blocker. In the present investigation, the whole cell versi …
The isolated rat uterus contraction induced by oxytocin and Ca+ + after high-K depolarization were markedly inhibited by tetrandrine (Tet). The depression was immediately reversed by addition of Ca++ to the bath fluid. Tet and verapamil (Ver), which shifted the cumulative dose-response curves to the right and depressed the maximal responses to CaCl2 acted as non-competitive antagonists. The oxytocin-induced Ca++-dependent contractions were depressed by 4.8 and 30 μM Tet. Tet 30 μM also inhibited the Ca++ o-dependent component of the contraction. The effect of Ver on isolated rat uterus was stronger than that of Tet. But up to 0.05 μM, it showed no effect on Ca+ +-dependent oxytocin contraction. These results indicate that Tet is an effective Ca+ +-antagonist very similar to Ver on isolated rat uteri.
Isoliensinine, a natural phenolic bisbenzyltetrahydroisoquinoline alkaloid, has received considerable attention for its potential biological effects such as antioxidant and anti-HIV activities. From the dog hepatic microsomes of isoliensinine, three new N-demethylated and O-demethylated metabolites, 2-N-desmethyl-isoliensinine (M1), 2-N-desmethylisoliensinine (M2), and 2-N-6-O-didesmethylisoliensinine (M3), were identified by high-performance liquid chromatography and data-dependent electrospray ionization tandem mass spectrometry. Possible metabolic pathways for isoliensinine have been proposed. The result should prove very helpful for evaluation of the drug-like properties of isoliensinine and other bisbenzylisoquinoline alkaloids.
The effect of tetrandrine (518343) (TD) on enhancing the actions of the mutagens mitomycin-C (50077) (MMC) and cigarette smoke condensate (CSC) were examined. Chinese-hamster cell lines were exposed for 3 hours to: 20 microliters CSC; 40 or 80 micrograms/milliliter (microg/ml) TD; or 20, 40, or 80 microliters TD plus 20 microliters CSC without S9 activation. The cells were also exposed to 0.01micr
isotetrandrine drug combination cycleanine cepharanthine berbamine: an extract consisting of cepharanthine, cycleanine, isotetrandrine, and berbamine; isolated from Stephania cepharantha
Cardiac effects of the extract and active components of radix stephaniae tetrandrae. II. Myocardial infarct, arrhythmias, coronary arterial flow and heart rate in the isolated perfused rat heart ...
Cardiac effects of the extract and active components of radix stephaniae tetrandrae. II. Myocardial infarct, arrhythmias, coronary arterial flow and heart rate in the isolated perfused rat heart ...
Yu, H-Hua.; Mi, W-Ning.; Liu, B.; Zhao, H-Peng., 2016: In vitro and in vivo effect of paclitaxel and cepharanthine co-loaded polymeric nanoparticles in gastric cancer
Biot-Pelletier,D., V.J.J. Martin. 2016. Seamless and site-directed mutagenesis of the Saccharomycescerevisae genome using CRISPR-Cas9. Journal of Biological Engineering. InPress.. Payne, M., L. Narcross, E.Fossati, L. Bourgeois and V.J.J. Martin.2016. Reconstituting plant secondarymetabolism in Saccharomyces cerevisiaefor production of high-value benzylisoquinoline alkaloids. Methods inEnzymology. In Press. Online 10 March 2016. Campbell, A., P.Bauchart, N.D. Gold, Y. Zhu, V. de Luca and V.J.J. Martin. 2016.Engineering of a nepetalactol-producing platform strain of Saccharomycescerevisiae for the production of seco-iridoids. ACS Synthetic Biology. Web PublicationDate: March 16, 2016. Larue, K., M. Melgarand V.J.J. Martin. 2016. Directed evolution of a fungal β-glucosidase in Saccharomyces cerevisiae. Biotechnology for Biofuels. 9:52. Narcross, L, E. Fossati, L. Bourgeois and V J.J. Martin. 2016.Microbial factories for the production of benzylisoquinoline alkaloids. Trendsin Biotechnology. ...
Reperfusion is an essential treatment to salvage ischemia myocardium from necrosis. However, the reperfusion can also lead to additional damage. Ischemic preconditioning is a powerful way to initiate intrinsic adaptive responses protecting the heart from subsequent severe ischemia/reperfusion (I/R) injury that can be mimicked by pharmacological preconditioning. However, so far few agents are clinically available for patients with ischemia heart disease. There is a growing interest in exploring effective cardioprotective components extracted from Traditional Chinese Medicine because they have been practiced for thousands of years, providing a vast source of pharmaceutical materials. Berbamine, a kind of bisbenzylisochinoline alkaloids derived from the roots, barks and stems of Barberry, was reported to protect myocardium from ischemia/reperfusion (I/R) injury, but the underlying mechanisms are largely unknown. Here, we investigated whether berbamine confers cardioprotection via preventing calpain ...
Ebb and Flow Definition - An ebb and flow system, also known as a flood and drain system, is a popular hydroponic growing system where theres an...
Now £67 (Was £̶8̶3̶) on TripAdvisor: Ebb Tide Oceanfront Inn, Seaside. See 1,128 traveller reviews, 348 candid photos, and great deals for Ebb Tide Oceanfront Inn, ranked #12 of 27 hotels in Seaside and rated 4 of 5 at TripAdvisor.
Contact an Demi Moore booking agent now to discuss pricing & fees with an Demi Moore agent to book Demi Moore for corporate events, private parties & public concerts worldwide.
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The Moore Township Planning Commission voted to approve the proposal to revise lot lines for the former Moore Estates Major Subdivision Plan. The property was purchased by Moore Township to be placed into Farmland Preservation, and then to be placed for sale after it is preserved, in which one home and farmstead ...
When considering the relocation of our finance team (c.20 FTE,) Axon Moore were recommended as a source of advice and market knowledge. The combination of finance expertise, in-depth knowledge of talent and understanding of culture & team dynamics was unique and allowed us to almost completely delegate recruitment, freeing up time to focus on process and system improvement and the successful delivery of the relocation. We continue to work with Axon Moore exclusively and would now consider them a key strategic partner.. ...
By Representative Beaton of Shrewsbury and Senator Moore, a joint petition (subject to Joint Rules 12) of Matthew A. Beaton and Michael O. Moore (by vote of the town) relative to authorizing the Division of Capital Asset Management and Maintenance to convey certain parcels of land in the town of Shrewsbury. House Rules. [Local Approval Received ...
Katherine is the kind of person who would bend over backwards for anyone in need. She has the bi… Bronson Cline needs your support for Support Katherine Moore
From Monday 9 September 2019, global accounting and consultancy network Moore Stephens relaunches our brand to become Moore. The unveiling of a new logo, visual identity and brand positioning marks the continued evolution of a network of more than 260 independent firms in 112 countries and a client-focused professional community of more than 30,000 people.. MOORE about the change of name ...
Demi Moore has opened up about life with ex husband Ashton Kutcher and claims he pressured her into having two threesomes which she regretted
Napa Sew & Vac has reached 40 years in business this year, a landmark that came despite many hardship and trials over the years for owner Russell Moore.
Fab service - quick delivery and email follow ups to see how you are getting on with the products. Also guide received on how to use the products. Will definitely be using them again!
Is it time to move to a larger or smaller space? Whether choosing to move now or later, you should start asking the right questions today. Read more t...
Support your journey to wellness and meet others on the same quest at my events and workshops. Be among the first to know when a new event is scheduled.
Courtney Moore is from 1986, the year I turned 11. Am I really old enough for my childhood to become part of a historical story?. Read More » ...
TY - JOUR. T1 - Neferine from Nelumbo nucifera induces autophagy through the inhibition of PI3K/Akt/mTOR pathway and ROS hyper generation in A549 cells. AU - Poornima, Paramasivan. AU - Weng, Ching Feng. AU - Padma, Viswanadha Vijaya. PY - 2013/12/15. Y1 - 2013/12/15. N2 - Previously we have reported that neferine from the medicinal plant Nelumbo nucifera, inhibited cancer cell proliferation by inducing apoptosis. The present study was focused on the action mechanism of neferine in inducing autophagy in lung cancer cells. Neferine markedly inhibited A549 cell proliferation in a dose dependent manner. Acidic vesicular accumulation was observed in neferine treated cells as an indication of autophagy. Neferine could induce the conversion of LC3B-I to LC3B-II without affecting the expression levels of PI3KCIII and Beclin1. It has been observed that neferine mediated autophagy is dependent on inhibition of PI3K/Akt/mTOR signaling by neferine. Neferine treatment could also lead to the ROS ...
Bisbenzylisoquinoline alkaloids were isolated from Stephania cepharantha Hayata and their proliferative activities on cultured hair cells from the murine skin were evaluated. Cepharanthine (1), cepharanoline (9), isotetrandrine (2), and berbamine (7) showed significant activities in the range of 0.01-0.1 microgram/ml, but had no activity on cultured keratinocytes or fibroblasts from the murine skin.
BioAssay record AID 680711 submitted by ChEMBL: TP_TRANSPORTER: increase in Rhodamine 123 intracellular accumulation (R123: 4 uM, Fangchinoline: 3 uM) in HCT15 cells.
Natural agents may be promising to combat aggressive behavior of the triple-negative breast cancer (TNBC). STAT3 is a protein that is highly expressed in breast cancer tissues compared to non-malignant breast tissues. Our objective for the present study is to analyze the anti-tumorogenic effects of a Chinese herbal drug, tetrandrine, in TNBC progression through inhibition of STAT3 phosphorylation.
Curine is a bisbenzylisoquinoline alkaloid (BBA) with anti-allergic, analgesic, and anti-inflammatory properties. Previous studies have demonstrated that this alkaloid is orally active at non-toxic doses. However, the mechanisms underlying its anti-inflammatory effects remain to be elucidated. This work aimed to investigate the effects of curine on macrophage activation and neutrophil recruitment. Using a murine model of lipopolysaccharide (LPS)-induced pleurisy, we demonstrated that curine significantly inhibited the recruitment of neutrophils in association with the inhibition of cytokines tumor necrosis factor (TNF-α), interleukin (IL)-1β, IL-6, monocyte chemotactic protein (CCL2/MCP-1) as well as leukotriene B4 in the pleural lavage of mice. Curine treatment reduced cytokine levels and the expression of iNOS in in vitro cultures of macrophages stimulated with LPS. Treatment with a calcium channel blocker resulted in comparable inhibition of TNF-α and IL-1β production, as well
When DArcy Wentworth Thompsons On Growth and Form was published 100 years ago, it raised the question of how biological forms arise during development and across evolution. In light of the advances in molecular and cellular biology since then, a succinct modern view of the question states: how do genes encode geometry? Our new special issue is packed with articles that use mathematical and physical approaches to gain insights into cell and tissue patterning, morphogenesis and dynamics, and that provide a physical framework to capture these processes operating across scales.. Read the Editorial by guest editors Thomas Lecuit and L. Mahadevan, as they provide a perspective on the influence of DArcy Thompsons work and an overview of the articles in this issue.. ...
Boc Sciences offers cas 118-08-1 (1R,9S)-(-)-β-Hydrastine in bulk,please inquire us to get a quote for 118-08-1 (1R,9S)-(-)-β-Hydrastine.
The Ebbs farmers market takes place from 9.00 am to 1.00 pm on the forecourt of the new kindergarten Ebbs under the strict, legal regulations. From bacon, cheese, fish, bread, vegetables, salad to
Tom Moore, Producer: Return to Boggy Creek. Tom Moore is a retired American film writer, producer, and director. Moore produced and directed more than a hundred TV commercials and multi-episode video series, but is best know for Return to Boggy Creek (1977). Moore worked in the Texas area with Director Charlie Pierce as a Line Producer on four films. The two met each other while working at a small TV station in El Dorado, Arkansas. Moore ...
When launching this site six years ago, my original intention was not only to write up critiques on a comprehensive body of metal works, but also to converse with the creators behind some of the most compelling and inspirational of recordings Ive encountered through my listening. Well, as the months (and years) rolled on, I really failed to launch on this aspect, finding it difficult to dig up the investment I had in the 90s when writing for a print zine. That all changes this Spring, as I embark on a monthly quest to pick the brains of some of the more fascinating authors of agony in the underground! Who better to start this with than the esoteric consciousness behind the Howls of Ebb, whose debut album through I, Voidhanger records has spent several nights with me on the very precipice of sanity...I was honored to speak with songwriter, vocalist and guitarist Z.L.H.. ...
Information on the #C3EBB0 html color code with its RGB and HSL make up, lighter and darker colors, analogous colors, and trinary colors.
Ebb lyrics by O.L.D.: Now I see / What I hate / Now I hate / What I see / See myself and what I hate / Now I hate / What I see / All must
Demi Moore Hospitalized, Seeking Professional Assistance Demi Moore is seeking professional assistance after being rushed to the hospital on Monday night (January 23). Paramedics responded to the 49-year-old actresss…
Moore, Archie, 1913-98, American boxer, b. Benoit, Miss., as Archie Lee Wright. He claimed to have been born in 1916 in Collinsville, Ill. He first boxed professionally as a middleweight in 1935 or 1936, winning his first 13 matches by knockouts. In a long and colorful career Moore, a clever boxer and dangerous puncher, engaged in 220 recorded bouts and scored 136 knockouts, a record in boxing history. In 1952 he won the light heavyweight title from Joey Maxim, holding it until 1962. Moore twice fought for the heavyweight championship-in 1955 he was beaten by Rocky Marciano, and in 1956 he lost to Floyd Patterson ...
DAU provides the Acquisition, Technology, and Logistics (AT&L) workforce training. All Service and DoD employees may attend DAU classes. Non-DoD federal agency and defense industry employees may attend DAU courses at no cost on a space available basis.
Fire up your raptors, Battlestar Galactica fans, the final season of the Peabody Award-winning show begins Jan. 16 at 10 pm/ET on Sci Fi. If youre like us, you have so... many... frakkin questions! The biggest one: Will all of our questions actually be answered? Executive producers Ron D. Moore and David Eick tease whats next for the four Cylons revealed this past season, assured us we wont need to wait the very last episode for the fifth Cylons identity and gave some details the prequel series, Caprica, which is set to air in early 2010.What are you most proud about the way the series ended?Ron Moore: I would have to say that Im probably most proud about the fact that I think we were able to answer most of the questions that wed raised over the years. And, sort of, to resolve most of the mysteries and the grander questions of the show and at the same time give a resolution to all the character arcs and to wrap it up by the end. And, we dont save everything until.... ...
The narrowest part of the channel is less than 2km long, but takes a huge volume of water through on each tide. We reckoned that the actual slack water was less than five minutes before we began to feel the insistent pull of the ebb drawing us into the narrows. A few swirls and hydraulic cushions began to appear as the ebb started to establish but in the absence of swell things were very gentle ...
Christina Moore Ms. Brooklyn - Five frenzied months into her reign as Miss Brooklyn Christina Moore is showing no signs of slowing down- or scaling back her hometown pride.
Shop Moore & Wright MW3318 Firm Joint Outside Caliper at Staples. Choose from our wide selection of Moore & Wright MW3318 Firm Joint Outside Caliper and get fast & free shipping on select orders.
American fuzzy lop is a security-oriented fuzzer that employs a novel type of compile-time instrumentation and genetic algorithms to automatically discover clean, interesting test cases that trigger new internal states in the targeted binary. This substantially improves the functional coverage for the fuzzed code. The compact synthesized corpora produced by the tool are also useful for seeding other, more labor- or resource-intensive testing regimes down the road. ...
The late, much lamented Paris-based English sculptor Raymond Mason (see obituary, 28 February, 2010) was an established raconteur. In 1954 Moore had invited him when in London to visit his studio. Moore had told Mason, patting on the head a large reclining figure,
Recently Congressman Mark Cojuangco has been quoting Moore, on the issue of nukes and I was wondering if had he not been formerly a part of Greenpeace would his opinion on the issue still count?. I recently stumbled upon this quote from Patrick Moore: ...
Model Mayhem is the #1 portfolio website for professional models and photographers. Create a profile, upload your photos and connect with other professionals
Model Mayhem is the #1 portfolio website for professional models and photographers. Create a profile, upload your photos and connect with other professionals
Tides are not formed along the entire coast of the seas and oceans, but only on those coasts with a high speed of currents. And the higher the speed of curre...
Tides are not formed along the entire coast of the seas and oceans, but only on those coasts with a high speed of currents. And the higher the speed of curre...
Dawn Moore, Hampton Bays mother of two, is a self-described poster child for the early detection of breast cancer. I have met so many women who are over 40, even a doctor friend of mine, who have n
Check out Tissue Paper Covered Leaf crafting ideas at A.C. Moore. Explore many more such exceptional art & craft products only here.
DARREN Moore says he will begin his reign as Albion Head Coach in the same vein he approached the final six games of last season.
I have been doing IT work for both residential and businesses for about 20 years. I recently started PC Networking & Moore in order to help provide support and expertise i...
With 168 deliveries and 170 babies (84 girls and 86 boys that included two sets of twins), Moore Regional broke the previous record of 166 deliveries that was set in 2009.
Moore Medical offers a variety of education and training materials including anatomical charts and models, manikins and simulators, reference and field guides and more.
Moore Medical offers a variety of education and training materials including anatomical charts and models, manikins and simulators, reference and field guides and more.
Kathryn Moore & Roxanne Wyss, The Electrified Cooks, LLC, develop recipes and set the standard for innovative, carefully tested, creative recipes and food information.
Heres a video from Michael Moore, you know that fat film maker that gets grants from US to make films breading hate and discontent. Thought you all might like to see it. Because it made my neck hairs stand up. http://www.theblaze.com/stories/michael-moore-people-own-guns-because-theyre-fearful-racists/
If youre searching for modern streetwear style inspiration with a 90s edge, look no further than Marj Moore. Use code __ATMKT5X10-7RNYFN-OCT2020__ to get €10,- off your order. [__Read our terms & conditions here |__](https://www.aceandtate.com/gb/legal/raf-curated-by-marketing-terms-and-conditions)
December 19 2017 my brothers and I received the most devastating news ever our beautiful m… Courtney Moore needs your support for We lost our mother suddenly
Shop the latest titles by H.B. Moore at Alibris including hardcovers, paperbacks, 1st editions, and audiobooks from thousands of sellers worldwide.
Patrick MOORE, analist i radios Evropa e Lirë RADIO EVROPA E LIRË Rusia është e gatshme të marrë pjesë më aktive në një zgjidhje të drejtë të problemit të Kosovës, ka deklaruar këtë javë Vladimir Putini. Do të thotë kjo që Rusia ende kërkon të ketë një rol aktiv në Ballkan? PATRICK...
Stuart Moore enjoyed the opportunity to showcase himself in front of manager Paul Tisdale in Tuesdays Carabao Cup tie with Southend United.
Buy Burning The Sky by Pat Moore as a Poster, Throw Pillow, Tote Bag, Art Print, Canvas Print, Framed Print, Photographic Print, Metal Print, or Greeting Card
See what Christy Moore (respiratory03) has discovered on Pinterest, the worlds biggest collection of everybodys favorite things.
ARTFINDER: Fire N Ice by Lucy Moore - I will ship Globally but please message me for a price I am very Proud of this piece of art work, the photographs dont do this piece any justice. This...
Dont worry, were just as shocked as you are! Demi Moore shared a photo of her missing her two teeth and explains just how they fell out.
Demi Moore cannot catch a break! A photographer has filed a battery report against the actress, after he claimed that she struck him as he tried to snap some...
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Burger A (2005) [1954]. "The Benzylisoquinoline Alkaloids". In Manske RH, Holmes HL (eds.). The Alkaloids: Chemistry and ...
... is an antimicrobial benzylisoquinoline alkaloid. Villar, A; Mares, M; Rios, JL; Canton, E; Gobernado, M (1987). " ... "Antimicrobial activity of benzylisoquinoline alkaloids". Die Pharmazie. 42 (4): 248-50. PMID 3615557. v t e (Pages using ... Benzylisoquinoline alkaloids, Dibenzoquinolines, Benzodioxoles, All stub articles, Alkaloid stubs). ...
Structurally, tubocurarine is a benzylisoquinoline derivative. For many years, its structure, when first elucidated in 1948, ... Benzylisoquinoline alkaloids, Cyclophanes, Macrocycles, Muscle relaxants, Neuromuscular blockers, Neurotoxins, Nicotinic ...
The plant also contains nuciferine, neferine and many other benzylisoquinoline alkaloids with medicinal properties. All parts ... Menendez-Perdomo, I. M. and P. J. Facchini (2018). "Benzylisoquinoline Alkaloids Biosynthesis in Sacred Lotus." Molecules 23(11 ... "Anti-HIV benzylisoquinoline alkaloids and flavonoids from the leaves of Nelumbo nucifera, and structure-activity correlations ... "Isolation and characterization of two O-methyltransferases involved in benzylisoquinoline alkaloid biosynthesis in sacred lotus ...
BIAdb: A Database for Benzylisoquinoline Alkaloids. The Benzylisoquinoline Alkaloid Database is an attempt to gather the ... A curated database of benzylisoquinoline alkaloids". BMC Pharmacology. 10: 4. doi:10.1186/1471-2210-10-4. PMC 2844369. PMID ...
McCorkindale NJ, Magrill DS, Martin-Smith M, Smith SJ, Stenlake JB (1964). "Petaline: A 7,8-dioxygenated benzylisoquinoline". ...
Hagel JM, Facchini PJ (May 2013). "Benzylisoquinoline alkaloid metabolism: a century of discovery and a brave new world". Plant ... S)-Norcoclaurine/Higenamine is at the center of benzylisoquinoline alkaloid (BIA) biosynthesis. In spite of large structure ... Beaudoin GA, Facchini PJ (July 2014). "Benzylisoquinoline alkaloid biosynthesis in opium poppy". Planta. 240 (1): 19-32. doi: ... "Anti-HIV benzylisoquinoline alkaloids and flavonoids from the leaves of Nelumbo nucifera, and structure-activity correlations ...
"Microbial production of plant benzylisoquinoline alkaloids". Proceedings of the National Academy of Sciences. 105 (21): 7393- ...
The first committed enzyme in benzylisoquinoline alkaloid biosynthesis in plants". J. Biol. Chem. 277 (37): 33878-83. doi: ... Stadler R, Kutchan TM, Zenk MH (1989). "(S)-Norcoclaurine is the central intermediate in benzylisoquinoline alkaloid ... This enzyme participates in benzylisoquinoline alkaloid biosynthesis. Stadler R, Zenk MH (1990). "A revision of the generally ...
It is based on the benzylisoquinoline structure. Reticuline is one of the alkaloids found in opium, and experiments in rodents ...
The most common structural types are the benzylisoquinolines and the aporphines. According to current knowledge, a total of ...
Bloodroot produces benzylisoquinoline alkaloids, primarily the toxin sanguinarine. The alkaloids are transported to and stored ... also produce such benzylisoquinoline alkaloids. Plant geneticists have identified and sequenced genes which produce the enzymes ...
Chorismic acid is a precursor to the amino acid tyrosine, the source of nitrogen in benzylisoquinoline alkaloids. Tyrosine can ... Singh, A.; Menéndez-Perdomo, I. M.; Facchini, P. J. (2019). "Benzylisoquinoline alkaloid biosynthesis in opium poppy: an update ... Noscapine (also known as Narcotine, Nectodon, Nospen, Anarcotine and (archaic) Opiane) is a benzylisoquinoline alkaloid, of the ... These reactions produce (S)-reticuline, a key branchpoint intermediate in the biosynthesis of benzylisoquinoline alkaloids. The ...
His dissertation was entitled, "Synthesis of Benzylisoquinoline Alkaloids." He traveled to the University of Virginia as a ...
2019). "Benzylisoquinoline alkaloid biosynthesis in opium poppy: an update." Phytochem Rev 18(6): 1457-1482 Menéndez-Perdomo I. ... which carries the benzylisoquinoline skeleton that gives its name to this pathway. The conversion of (S) -norcoclaurin to (S) - ... M., Hagel J.M. and Facchini P.J. (2021). "Benzylisoquinoline alkaloid analysis using high-resolution Orbitrap LC-MSn." J Mass ... synthesized through the metabolic pathway of benzylisoquinoline. First, the amino acid phenylalanine, through the enzyme ...
Rueffer M, Zenk MH (1987). "Distant precursors of benzylisoquinoline alkaloids and their enzymatic formation". Z. Naturforsch. ...
It is also an intermediate in the complex biosynthesis of noscapine, which is likewise a benzylisoquinoline alkaloid, but of ... S)-Canadine, also known as (S)-tetrahydroberberine and xanthopuccine, is a benzylisoquinoline alkaloid (BIA), of the ... "Transcriptome analysis of 20 taxonomically related benzylisoquinoline alkaloid-producing plants". BMC Plant Biology. 15: 227. ...
... , a bis-benzylisoquinoline alkaloid, is a calcium channel blocker. It is isolated from the plant Stephania tetrandra ... Kwan, C. Y.; Achike, F. I. (2002). "Tetrandrine and related bis-benzylisoquinoline alkaloids from medicinal herbs: ... Kwan, C. Y.; Achike, F. I. (2002). "Tetrandrine and related bis-benzylisoquinoline alkaloids from medicinal herbs: ...
... , also known as discretamine and aequaline, is a benzylisoquinoline alkaloid (BIA) that is derived directly from (S)- ... "Transcriptome analysis of 20 taxonomically related benzylisoquinoline alkaloid-producing plants". BMC Plant Biology. 15: 227. ...
... is metabolically derived from the benzylisoquinoline alkaloid (S)-Reticuline through a progressive series of five ... "Transcriptome analysis of 20 taxonomically related benzylisoquinoline alkaloid-producing plants". BMC Plant Biology. 15: 227. ...
S)-Cheilanthifoline is a benzylisoquinoline alkaloid (BIA) which has been isolated from Corydalis dubia and Argemone mexicana.[ ... "Transcriptome analysis of 20 taxonomically related benzylisoquinoline alkaloid-producing plants". BMC Plant Biology. 15: 227. ...
Also, marks a branch point in the biosynthesis of benzylisoquinoline alkaloids. As mentioned above, BBE-like enzymes are in the ...
... or related benzylisoquinoline precursors, which in turn are derived from tyrosine (2). Feeding studies (Aristolochia sipho) ... The first enzyme in the benzylisoquinoline biosynthetic pathway". FEBS Letters. 129: 5-9. doi:10.1016/0014-5793(81)80742-9. ...
Benzylisoquinoline alkaloids include aporphines and oxoaporphines, as well as derivatives of morphinans. Essential oils include ...
... is a benzylisoquinoline alkaloid with two additional ring closures. As Jack DeRuiter of the Department of Drug ...
Benzylisoquinoline alkaloids (BIAs) are a structurally diverse group of plant specialized metabolites with a long history of ... Hagel, J. M, & Facchini, P. J. (2013). Benzylisoquinoline Alkaloid Metabolism: A Century of Discovery and a Brave New World. ...
1-Benzylisoquinoline is the structural backbone in naturally occurring alkaloids including papaverine. The isoquinoline ring in ...
... contains two groups of alkaloids: phenanthrenes (including morphine and codeine) and benzylisoquinolines (including ...
Benzylisoquinolines, such as atracurium and tubocurarine, the other major group of neuromuscular blocking agents Ted Lin; Tim ...
Mivacurium belongs to a class of compounds that is commonly and erroneously referred to as "benzylisoquinolines;" mivacurium is ... Partial saturation of the benzylisoquinoline ring to the tetrahydroisoquinoline ring provided an even further increase in ... the use of a benzylisoquinoline neuromuscular blocking agent. The heritage of mivacurium and indeed its very closely related ...
1-Benzylisoquinolines as precursors of thebaine, codeine, and morphine". J Chem Soc: 3600. Benzylisoquinoline biosynthesis by ... the most widely examined of the numerous benzylisoquinoline structural isomers. The 1-benzylisoquinoline moiety can be ... Hagel, Jillian M; Facchini, Peter J (2013). "Benzylisoquinoline alkaloid metabolism: A century of discovery and a brave new ... Substitution of the heterocycle isoquinoline at the C1 position by a benzyl group provides 1‑benzylisoquinoline, ...
Hagel, J.M. & Facchini, P.J. Benzylisoquinoline alkaloid metabolism: a century of discovery and a brave new world. Plant Cell ... Plant cytochrome P450s directing monoterpene indole alkaloid (MIA) and benzylisoquinoline alkaloid (BIA) biosynthesis *Danielle ... Desgagné-Penix, I. & Facchini, P.J. Systematic silencing of benzylisoquinoline alkaloid biosynthetic genes reveals the major ... O-demethylenation with widespread roles in benzylisoquinoline alkaloid metabolism in opium poppy. J. Biol. Chem. 288, 28997- ...
A curated database of benzylisoquinoline alkaloids. BMC Pharmacology 10:4.. ...
Benzylisoquinolines/chemistry; Benzylisoquinolines/pharmacology; COVID-19/drug therapy; COVID-19/metabolism; COVID-19/pathology ... Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Benzylisoquinolines ... Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Benzylisoquinolines ... Identification of bis-benzylisoquinoline alkaloids as SARS-CoV-2 entry inhibitors from a library of natural products. ...
The clinical pharmacology of new benzylisoquinoline-diester compounds, with special consideration of cisatracurium and ... The clinical pharmacology of new benzylisoquinoline-diester compounds, with special consideration of cisatracurium and ...
Papaverine is a benzylisoquinoline derivative with a direct nonspecific relaxant effect on vascular, cardiac, and other smooth ...
Papaverine is a benzylisoquinoline derivative with a direct nonspecific relaxant effect on vascular, cardiac, and other smooth ...
The narcotic called morphine is a Benzylisoquinoline alkaloid. History of Morphine According to Tétényi, there is no one way ...
benzylisoquinoline alkaloids from Argemone mexicana. Z. Naturforsch. 58: 521-526. Dalvi, R. R (1985) Sanguinarine: its ...
Tetrandrine is a benzylisoquinoline alkaloid that has been used in China as an antifibrotic drug to treat the lesions of ...
Hawkins, Kristy M. Smolke, Christina, D. "Production of benzylisoquinoline alkaloids in Saacharomyces cerevisiae." Nature ...
Hagel JM, Facchini PJ, Benzylisoquinoline alkaloid metabolism: A century of discovery and a brave new world. Plant and Cell ...
They are similar to BENZYLISOQUINOLINES. Members include chelerythrine and sanguinarine.. Terms. Benzophenanthridines Preferred ... They are similar to BENZYLISOQUINOLINES. Members include chelerythrine and sanguinarine.. Registry Number. 0. Previous Indexing ...
The Stereochemistry at C-13 for the Proaporphine-benzylisoquinoline Alkaloids. Inge Weiss,* Alan J. Freyer, Maurice Shamma, and ... Berberidaceae) has yielded the new proaporphine-benzylisoquinolines (+)-epiberbivaldine (13) and (+)-rupancamine (15). The ...
Tetrandrine (NSC-77037, Fanchinine, d-Tetrandrine), a bis-benzylisoquinoline alkaloid derived from Stephania tetrandra, is a ...
... benzylisoquinoline alkaloids [4], aporphine and proaporphine alkaloids[6]. In previous studies, we found that this herbal ...
We report low μM binding to structurally diverse alkyl, steroidal, curarine and benzylisoquinoline NMBAs with high selectivity ...
Plants of the order Ranunculales, especially members of the species Papaver, accumulate a large variety of benzylisoquinoline ... exhibiting an expression pattern very similar to previously isolated cDNAs coding for enzymes in benzylisoquinoline ...
We found 153 Words with Z and Q in our dictionary. You can use these word lists for Scrabble, Words With Friends and other word games.
Noscapine (NSC) is a benzyl-isoquinoline alkaloid discovered in 1930 as an antitussive agent. Recently, NSC has also been ... translocations and duplications within 7.7 million years have assembled nine genes into the benzylisoquinoline alkaloids gene ...
D03.132.098 Benzylisoquinolines .. D03.132.098.038 Aporphines .. D03.132.098.038.290 Apomorphine .. D03.132.577 Opiate ... D03.633.100.531.085 Benzylisoquinolines .. D03.633.100.531.085.030 Aporphines .. D03.633.100.531.085.030.290 Apomorphine .. ...
D03.132.098 Benzylisoquinolines .. D03.132.098.833 Toxiferine .. D03.132.098.833.050 Alcuronium .. D03.633 Heterocyclic ... D03.633.100.531.085 Benzylisoquinolines .. D03.633.100.531.085.777 Toxiferine .. D03.633.100.531.085.777.050 Alcuronium .. ...
Comments: A cytochrome P-450 (heme-thiolate) protein involved in benzylisoquinoline alkaloid synthesis in higher plants.. Links ... 450-dependent mono-oxygenase of benzylisoquinoline alkaloid biosynthesis. Plant J. 13 (1998) 793-801. [PMID: 9681018]. [EC 1.14 ...
Papaverine is a benzylisoquinoline derivative with a direct nonspecific relaxant effect on vascular, cardiac, and other smooth ...
BENZYLISOQUINOLINE ALKALOIDS FROM BARK OF Cryptocarya rugulosa Nurdin Saidi, Hiroshi Morita, Marc Litaudon, Mat Ropi Mukhtar, ...
BENZYLISOQUINOLINE ALKALOIDS FROM BARK OF Cryptocarya rugulosa. Abstract Full Text PDF Nurdin Saidi, Hiroshi Morita, Marc ...
This graph shows the total number of publications written about "Amaryllidaceae Alkaloids" by people in Harvard Catalyst Profiles by year, and whether "Amaryllidaceae Alkaloids" was a major or minor topic of these publication ...
  • but most notably it is found within the structures of a wide variety of plant natural products, collectively referred to as benzylisoquinoline alkaloids. (wikipedia.org)
  • These pathways collectively lead to the structurally disparate compounds comprising the broad classification of plant natural products referred to as benzylisoquinoline alkaloids (BIA), which have been comprehensively discussed by Hagel. (wikipedia.org)
  • Singla D, Sharma A, Kaur J, Panwar B, and Raghava GPS (2010): BIAdb: A curated database of benzylisoquinoline alkaloids. (osdd.net)
  • Identification of bis-benzylisoquinoline alkaloids as SARS-CoV-2 entry inhibitors from a library of natural products. (bvsalud.org)
  • P lants of the order Ranunculales, especially members of the species Papaver, accumulate a large variety of benzylisoquinoline alkaloids with about 2500 structures, but only the opium poppy (Papaver somniferum) and Papaver setigerum are able to produce the analgesic and narcotic morphine and the antitussive codeine. (opioids.com)
  • They produce chemicals called benzylisoquinoline alkaloids that are related to morphine and codeine. (doesgodexist.today)
  • Berberine extract- Berberine is a quaternary ammonium salt from the protoberberine group of benzylisoquinoline alkaloids found in such plants as Berberis. (healthlinemags.com)
  • Berberine extract- Berberine is a quaternary ammonium salt from the protoberberine crew of benzylisoquinoline alkaloids located in such flora as Berberis. (bookkeepingjournal.com)
  • Benzylisoquinoline alkaloids (BIAs) have a common biosynthetic pathway that in plants derives from L-Tyrosine and has, among others, dopamine and S-reticuline as intermediates. (mappingignorance.org)
  • Berberine extract- Berberine is a quaternary ammonium salt from the protoberberine team of benzylisoquinoline alkaloids observed in such vegetation as Berberis. (whitefeatherdesign.com)
  • At the time, my lab work focused on the evolution of benzylisoquinoline alkaloids and cancer drugs, but came to include a study of the coumarins and neolignans (etoposide derivatives) involving other Magnoliidae-Berberidaceae plants lacking the expected alkaloidal paths. (brianaltonenmph.com)
  • 1. Pauli, H.H. and Kutchan, T.M. Molecular cloning and functional heterologous expression of two alleles encoding ( S )- N- methylcoclaurine 3'-hydroxylase (CYP80B1), a new methyl jasmonate-inducible cytochrome P- 450-dependent mono-oxygenase of benzylisoquinoline alkaloid biosynthesis. (qmul.ac.uk)
  • Het helpt je niet first trailblazing bestseller, Conscious Loving, more than 20 bespreken of er door of benzylisoquinoline alkaloid biosynthesis as a negative incentive. (nickoz.jp)
  • One of these cDNAs, exhibiting an expression pattern very similar to previously isolated cDNAs coding for enzymes in benzylisoquinoline biosynthesis, showed the highest amino acid identity to reductases in menthol biosynthesis. (opioids.com)
  • The clinical pharmacology of new benzylisoquinoline-diester compounds, with special consideration of cisatracurium and mivacurium]. (cornell.edu)
  • By far the most studied compounds are the benzylisoquinolines, especially tetrandrine. (heilpflanzen-welt.de)
  • Tetrandrine is a benzylisoquinoline alkaloid that has been used in China as an antifibrotic drug to treat the lesions of silicosis. (cdc.gov)
  • Tetrandrine (NSC-77037, Fanchinine, d-Tetrandrine), a bis-benzylisoquinoline alkaloid derived from Stephania tetrandra, is a calcium channel blocker. (selleckchem.com)
  • Some pharmaceutical painkillers and analgesics like Noscapine, papaverine and tubocurarine or the most famous opioids codeine or morphine are Benzylisoquinoline derivatives. (mappingignorance.org)
  • A cytochrome P- 450 (heme-thiolate) protein involved in benzylisoquinoline alkaloid synthesis in higher plants. (qmul.ac.uk)
  • Noscapine (also known as Narcotine, Nectodon, Nospen, Anarcotine and (archaic) Opiane) is a benzylisoquinoline alkaloid from plants of the Papaveraceae family, without painkilling properties. (termwiki.com)
  • Substitution of the heterocycle isoquinoline at the C1 position by a benzyl group provides 1‑benzylisoquinoline, the most widely examined of the numerous benzylisoquinoline structural isomers. (wikipedia.org)
  • They are similar to BENZYLISOQUINOLINES . (nih.gov)