OrganismsDiseasesChemicals and DrugsInformation ScienceNamed GroupsGeographicals
Benzylisoquinolines3,4-Dihydroxyphenylacetic AcidTetrahydropapaverolineDopa DecarboxylaseCoptisPapaverThalictrumOpiumNoscapineBerberine AlkaloidsTubocurarineEncyclopedias as Topicp-HydroxyamphetamineCurareSouth AmericaAmerican Native Continental Ancestry GroupAtracuriumCalcium Channel BlockersMibefradilAlkaloidsCalcium ChannelsNeuroblastomaFlunarizinePapaverineMuscle Relaxants, Central
Benzylisoquinolines
ISOQUINOLINES with a benzyl substituent.
3,4-Dihydroxyphenylacetic Acid
A deaminated metabolite of LEVODOPA.
Tetrahydropapaveroline
A leukomaine (animal alkaloid) formed in brain and liver from dopamine and L-dopa; it may be implicated in psychiatric problems.
Dopa Decarboxylase
One of the AROMATIC-L-AMINO-ACID DECARBOXYLASES, this enzyme is responsible for the conversion of DOPA to DOPAMINE. It is of clinical importance in the treatment of Parkinson's disease.
Coptis
A plant genus of the family RANUNCULACEAE. Members contain BERBERINE and other isoquinoline ALKALOIDS.
Papaver
A genus of Eurasian herbaceous plants, the poppies (family PAPAVERACEAE of the dicotyledon class Magnoliopsida), that yield OPIUM from the latex of the unripe seed pods.
Thalictrum
A plant genus of the family RANUNCULACEAE. Members contain isoquinoline alkaloids and triterpene glycosides.
Opium
The air-dried exudate from the unripe seed capsule of the opium poppy, Papaver somniferum, or its variant, P. album. It contains a number of alkaloids, but only a few - MORPHINE; CODEINE; and PAPAVERINE - have clinical significance. Opium has been used as an analgesic, antitussive, antidiarrheal, and antispasmodic.
Noscapine
A naturally occurring opium alkaloid that is a centrally acting antitussive agent.
Berberine Alkaloids
A group of related plant alkaloids that contain the BERBERINE heterocyclic ring structure.
Tubocurarine
A neuromuscular blocker and active ingredient in CURARE; plant based alkaloid of Menispermaceae.
Encyclopedias as Topic
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
p-Hydroxyamphetamine
Amphetamine metabolite with sympathomimetic effects. It is sometimes called alpha-methyltyramine, which may also refer to the meta isomer, gepefrine.
Curare
Plant extracts from several species, including genera STRYCHNOS and Chondodendron, which contain TETRAHYDROISOQUINOLINES that produce PARALYSIS of skeletal muscle. These extracts are toxic and must be used with the administration of artificial respiration.
South America
American Native Continental Ancestry Group
Individuals whose ancestral origins are in the continents of the Americas.
Atracurium
A non-depolarizing neuromuscular blocking agent with short duration of action. Its lack of significant cardiovascular effects and its lack of dependence on good kidney function for elimination provide clinical advantage over alternate non-depolarizing neuromuscular blocking agents.
Calcium Channel Blockers
A class of drugs that act by selective inhibition of calcium influx through cellular membranes.
Mibefradil
A benzimidazoyl-substituted tetraline that selectively binds and inhibits CALCIUM CHANNELS, T-TYPE.
Alkaloids
Organic nitrogenous bases. Many alkaloids of medical importance occur in the animal and vegetable kingdoms, and some have been synthesized. (Grant & Hackh's Chemical Dictionary, 5th ed)
Calcium Channels
Voltage-dependent cell membrane glycoproteins selectively permeable to calcium ions. They are categorized as L-, T-, N-, P-, Q-, and R-types based on the activation and inactivation kinetics, ion specificity, and sensitivity to drugs and toxins. The L- and T-types are present throughout the cardiovascular and central nervous systems and the N-, P-, Q-, & R-types are located in neuronal tissue.
Neuroblastoma
A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
Flunarizine
Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy.
Papaverine
An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
Muscle Relaxants, Central
A heterogeneous group of drugs used to produce muscle relaxation, excepting the neuromuscular blocking agents. They have their primary clinical and therapeutic uses in the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. They have been used also for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in MULTIPLE SCLEROSIS. (From Smith and Reynard, Textbook of Pharmacology, 1991, p358)

Inhibition of human immunodeficiency virus type 1 replication by combination of transcription inhibitor K-12 and other antiretroviral agents in acutely and chronically infected cells. (1/274)

8-Difluoromethoxy-1-ethyl-6-fluoro-1,4-dihydro-7-[4-(2-methoxyp hen yl)-1- piperazinyl]-4-oxoquinoline-3-carboxylic acid (K-12) has recently been identified as a potent and selective inhibitor of human immunodeficiency virus type 1 (HIV-1) transcription. In this study, we examined several combinations of K-12 and other antiretroviral agents for their inhibitory effects on HIV-1 replication in acutely and chronically infected cell cultures. Combinations of K-12 and a reverse transcriptase (RT) inhibitor, either zidovudine, lamivudine, or nevirapine, synergistically inhibited HIV-1 replication in acutely infected MT-4 cells. The combination of K-12 and the protease inhibitor nelfinavir (NFV) also synergistically inhibited HIV-1, whereas the synergism of this combination was weaker than that of the combinations with the RT inhibitors. K-12 did not enhance the cytotoxicities of RT and protease inhibitors. Synergism of the combinations was also observed in acutely infected peripheral blood mononuclear cells. The combination of K-12 and cepharanthine, a nuclear factor kappa B inhibitor, synergistically inhibited HIV-1 production in tumor necrosis factor alpha-stimulated U1 cells, a promonocytic cell line chronically infected with the virus. In contrast, additive inhibition was observed for the combination of K-12 and NFV. These results indicate that the combinations of K-12 and clinically available antiretroviral agents may have potential as chemotherapeutic modalities for the treatment of HIV-1 infection.  (+info)

Effects of dauricine, quinidine, and sotalol on action potential duration of papillary muscles in vitro. (2/274)

AIM: To compare the characteristics of dauricine, sotalol, and quinidine on action potential duration (APD). METHODS: Using intracellular microelectrode method to record APD in guinea pig papillary muscles. RESULTS: Dauricine 20 mumol.L-1 prolonged action potential at 90% repolarization, the percent of APD prolongation were 22 +/- 8, 11 +/- 6, 9 +/- 5, 7 +/- 5, 6 +/- 3, 4.3 +/- 2.8, 4.5 +/- 2.8 at the cycle lengths of 200-2000 ms, dauricine became more effective in lengthening APD at short cycle lengths. The effect of dauricine on prolonging APD exhibited normal use-dependence, whereas quinidine 1 mumol.L-1 and sotalol 10 mumol.L-1 were less effective in lengthening APD at short cycle lengths. The effect of quinidine and sotalol on APD exhibited reverse use-dependence. CONCLUSSION: The effect of dauricine on APD depends on activation frequency.  (+info)

Effect of tetrandrine on proto-oncogene c-fos expression in rat cerebrum. (3/274)

AIM: To detect the effect of tetrandrine (Tet) on c-fos gene expression in cerebrum induced by lindane, a neurotoxicant which activates Ca2+ channels. METHODS: Northern and dot blotting, dual wavelength thin layer chromatography scanner, were used in this study. RESULTS: Lindane 30 mg.kg-1 given by intragastric gavage (i.g.) increased the expression of c-fos gene to 146 mm2 in rat cerebrum 1 h after treatment. Tet 1, 2, and 4 mg.kg-1 given by i.g. 30 min prior to lindane reduced c-fos gene expression in a concentration-dependent manner. Expressed genes reached only 86, 40, and 39 mm2, respectively. CONCLUSION: Tet inhibited c-fos gene expression in rat cerebrum induced by Ca2+ agonist-lindane.  (+info)

Stimulation of pregnant rat uterine contraction by the polychlorinated biphenyl (PCB) mixture aroclor 1242 may be mediated by arachidonic acid release through activation of phospholipase A2 enzymes. (4/274)

The polychlorinated biphenyl (PCB) mixture Aroclor 1242 (A1242) increases frequency of contractions of pregnant rat uteri, suggesting a possible mechanism for decreased gestational age and increased spontaneous abortion in women and animals exposed to PCBs. In the present study, we hypothesized that A1242-induced stimulation of uterine contraction is mediated by arachidonic acid released by phospholipase A2 (PLA2) enzymes. Isometric uterine contraction was measured in longitudinal uterine strips isolated from gestation day 10 rat. Pretreatment of uterine strips with the PLA2 inhibitor (E)-6-(bromomethylene)tetrahydro-3-(1-naphthalenyl)-2H-pyran-2-one (HELSS) or manoalide, or an inhibitor of the G protein of PLA2, isotetrandrine, completely prevented the increase of contractile frequency induced by 50 microM A1242. However, the phospholipase C inhibitors 2-nitro-4-carboxyphenyl-N,N-diphenylcarbamate (NCDC) and neomycin were unable to block stimulation of uterine contraction by A1242. In accordance, A1242 (100 microM) did not release inositol phosphates from myo-[3H]inositol-labeled myometrial cells, whereas myometrial cells prelabeled with [3H]arachidonic acid released arachidonic acid in a concentration- and time-dependent manner after exposure to A1242 (10-100 microM). A1242 significantly stimulated arachidonic acid release in the absence of extracellular calcium, although the release was attenuated. Analysis of the eicosanoids released by A1242 indicated that only 0.83% of released [3H]arachidonic acid was metabolized to eicosanoids and 99.07% remained as free arachidonate. Uterine contraction increased in strips exposed to exogenous arachidonic acid (1-100 microM). This study suggests that A1242 stimulates contraction in pregnant rat uterus by a mechanism involving PLA2-mediated arachidonic acid release, and that arachidonic acid, rather than eicosanoids, may mediate A1242 uterotonic action in the uterus.  (+info)

Tetrandrine inhibited chronic "inflammatory" pulmonary hypertension in rats. (5/274)

AIM: To study the effects of tetrandrine (Tet), on pulmonary hypertension. METHODS: An "inflammatory" chronic pulmonary hypertension induced by monocrotaline (Mon) in rats was used. RESULTS: Tet 50, 100, and 150 mg.kg-1.d-1 i.g. 3 wk inhibited Mon-induced increase of pulmonary artery pressure (PAP) by 23.8%, 34.9% (P < 0.05), and 42.0%, (P < 0.05); the right heart index by 2.0%, 25.0%, and 30.0% (P < 0.05) respectively compared with those from Mon group, without significant influence on the systemic artery pressure (SAP). Using histological exam by Verhoeff elastic stain and computer scanning analysis, it was found that Tet (100 mg.kg-1.d-1) for 3 wk, inhibited the increase of medial thickness and cross sectional area by 57.8% (P < 0.01) and 54.6% (P < 0.01), respectively vs Mon group. CONCLUSION: Tet ameliorated the development of pulmonary vascular and lung tissue injury induced by Mon in rats.  (+info)

Dauricine inhibited L-type calcium current in single cardiomyocyte of guinea pig. (6/274)

AIM: To study the effect of dauricine (Dau) on L-type calcium current in guinea pig ventricular myocytes. METHODS: Using whole-cell recording method to record L-type calcium current (ICa) in single ventricular cell of guinea pig. RESULTS: Dau 1, 10, and 100 mumol.L-1 markedly reduced ICa by 15.2% +/- 2.2%, 41% +/- 5%, and 82% +/- 8%, respectively. After washing out, ICa partially recovered. Dau inhibited ICa at 3 Hz and 1 Hz to a similar extent, its effect on ICa appeared to be not frequency-dependent. CONCLUSION: Dau had a calcium channel blocking effect.  (+info)

Effects of anti-rheumatic herbal medicines on cellular adhesion molecules. (7/274)

OBJECTIVE: To test the hypothesis whether herbal medicines ameliorate inflammatory diseases via the modulation of cellular adhesion molecules (CAMs). METHODS: Human neutrophils, synovial fibroblasts, and endothelial cells were incubated with different concentrations of Tripterygium Wilfordii Hook-f (TWH-f) or Tetrandrine in the presence or absence of interleukin 1 (IL1). The amount of soluble E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cellular adhesion molecule-1 (VCAM-1) secreted by cells were determined by ELISA. The cell surface expression of these three CAMs was detected by flow cytometry. RESULTS: TWH-f at high concentration (50 ng/ml) has a significant (p<0.05) inhibitory effect on both the secretion and the expression of the cellular adhesion molecules. However, Tetrandrine did not demonstrate the same effects. CONCLUSIONS: The cellular adhesion molecules of the endothelium and leucocytes may constitute excellent targets for the development of new anti-inflammation medicines. These results indicate that TWH could be a potential therapeutic agent in the treatment of inflammatory diseases.  (+info)

Effects of N-methyl berbamine on delayed outward potassium current in isolated rat hepatocytes. (8/274)

AIM: To study the effects of N-methyl berbamine (NMB) on the delayed outward potassium currents (Ik) in isolated rat hepatocytes. METHODS: With patch-clamp techniques and whole-cell recording method, holding potential -50 mV, command potential +30 to +140 mV, duration 900 ms. RESULTS: NMB reduced Ik in a concentration-dependent manner. When the concentrations of NMB were 20, 50, 400 nmol.L-1 and 50 mumol.L-1, the amplitude values of Ik were decreased to 3.6 +/- 0.4 (P > 0.05), 2.1 +/- 1.6 (P > 0.05), 3.7 +/- 1.6 (P < 0.05), 2.3 +/- 1.3 nA (P < 0.01) from 4.4 +/- 1.0 (n = 4), 2.5 +/- 1.8 (n = 4), 5.8 +/- 2.1 (n = 5), 4.6 +/- 1.3 (n = 6) nA of control, respectively. The inhibitory rates were 10%, 15%, 37%, and 51%, respectively. CONCLUSION: NMB was a K+ channel inhibitor.  (+info)

Tetrandrine - WikipediaTetrandrine - Wikipedia
Tetrandrine a bis-benzylisoquinoline alkaloid, is a calcium channel blocker. It has anti-inflammatory, immunologic and antiallergenic effects. It inhibits the degranulation of mast cells. It has a quinidine-like anti-arrhythmic effect. It has been isolated from Stephania tetrandra S Moore, and other Chinese and Japanese herbs. It has vasodilatory properties and can therefore reduce blood pressure. Tetrandrine may have potential use for the treatment of liver disease and liver cancer. Tetrandrine has potential therapeutic value to prevent excess scarring/fibrosis in conjunctiva following trabeculectomy or in patients with severe conjunctival inflammation. Tetrandrine has anti-inflammatory and anti-fibrogenic actions, which make tetrandrine and related compounds potentially useful in the treatment of lung silicosis, liver cirrhosis, and rheumatoid arthritis. Tetrandrine has also been shown to inhibit entry of Ebola virus into host cells in vitro and showed therapeutic efficacy against Ebola in ...
https://en.wikipedia.org/wiki/Tetrandrine
BIAdb: A curated database of benzylisoquinoline alkaloids | BMC Pharmacology | Full TextBIAdb: A curated database of benzylisoquinoline alkaloids | BMC Pharmacology | Full Text
Benzylisoquinoline is the structural backbone of many alkaloids with a wide variety of structures including papaverine, noscapine, codeine, morphine, apomorphine, berberine, protopine and tubocurarine. Many benzylisoquinoline alkaloids have been reported to show therapeutic properties and to act as novel medicines. Thus it is important to collect and compile benzylisoquinoline alkaloids in order to explore their usage in medicine. We extract information about benzylisoquinoline alkaloids from various sources like PubChem, KEGG, KNApSAcK and manual curation from literature. This information was processed and compiled in order to create a comprehensive database of benzylisoquinoline alkaloids, called BIAdb. The current version of BIAdb contains information about 846 unique benzylisoquinoline alkaloids, with multiple entries in term of source, function leads to total number of 2504 records. One of the major features of this database is that it provides data about 627 different plant species as a source of
https://bmcpharma.biomedcentral.com/articles/10.1186/1471-2210-10-4/figures/1
Tetrandrine: a novel calcium channel antagonist inhibits type I calcium channels in neuroblastoma cellsTetrandrine: a novel calcium channel antagonist inhibits type I calcium channels in neuroblastoma cells
Tetrandrine, an alkaloid isolated from the Chinese herb, Radix stephaniae tetrandrae, has been used clinically as a hypotensive agent for a long time. Recently, several studies have demonstrated that tetrandrine behaves like a calcium entry blocker. In the present investigation, the whole cell versi …
https://pubmed.ncbi.nlm.nih.gov/1787886/?dopt=Abstract
Studies on the calcium antagonistic action of tetrandrine: VI. Effects of tetrandrine on contractility of isolated rat uterus -...Studies on the calcium antagonistic action of tetrandrine: VI. Effects of tetrandrine on contractility of isolated rat uterus -...
The isolated rat uterus contraction induced by oxytocin and Ca+ + after high-K depolarization were markedly inhibited by tetrandrine (Tet). The depression was immediately reversed by addition of Ca++ to the bath fluid. Tet and verapamil (Ver), which shifted the cumulative dose-response curves to the right and depressed the maximal responses to CaCl2 acted as non-competitive antagonists. The oxytocin-induced Ca++-dependent contractions were depressed by 4.8 and 30 μM Tet. Tet 30 μM also inhibited the Ca++ o-dependent component of the contraction. The effect of Ver on isolated rat uterus was stronger than that of Tet. But up to 0.05 μM, it showed no effect on Ca+ +-dependent oxytocin contraction. These results indicate that Tet is an effective Ca+ +-antagonist very similar to Ver on isolated rat uteri.
https://www.semanticscholar.org/paper/Studies-on-the-calcium-antagonistic-action-of-tetr-Da-chao-Wei-xing/288632f5ee99dd9197cb02806a10309c5b52507f
Molecules | Free Full-Text | Identification of Three New N-Demethylated and O-Demethyled Bisbenzylisoquinoline Alkaloid...Molecules | Free Full-Text | Identification of Three New N-Demethylated and O-Demethyled Bisbenzylisoquinoline Alkaloid...
Isoliensinine, a natural phenolic bisbenzyltetrahydroisoquinoline alkaloid, has received considerable attention for its potential biological effects such as antioxidant and anti-HIV activities. From the dog hepatic microsomes of isoliensinine, three new N-demethylated and O-demethylated metabolites, 2-N-desmethyl-isoliensinine (M1), 2-N-desmethylisoliensinine (M2), and 2-N-6-O-didesmethylisoliensinine (M3), were identified by high-performance liquid chromatography and data-dependent electrospray ionization tandem mass spectrometry. Possible metabolic pathways for isoliensinine have been proposed. The result should prove very helpful for evaluation of the drug-like properties of isoliensinine and other bisbenzylisoquinoline alkaloids.
http://mdpi.com/1420-3049/17/10/11712/xml
NIOSHTIC-2 Publications Search - 00205407 - Enhancing effect of tetrandrine on sister-chromatid exchanges induced by mitomycin...NIOSHTIC-2 Publications Search - 00205407 - Enhancing effect of tetrandrine on sister-chromatid exchanges induced by mitomycin...
The effect of tetrandrine (518343) (TD) on enhancing the actions of the mutagens mitomycin-C (50077) (MMC) and cigarette smoke condensate (CSC) were examined. Chinese-hamster cell lines were exposed for 3 hours to: 20 microliters CSC; 40 or 80 micrograms/milliliter (microg/ml) TD; or 20, 40, or 80 microliters TD plus 20 microliters CSC without S9 activation. The cells were also exposed to 0.01micr
https://www.cdc.gov/niosh/nioshtic-2/00205407.html
isotetrandrine drug combination cycleanine cepharanthine berbamine Summary Report | CureHunterisotetrandrine drug combination cycleanine cepharanthine berbamine Summary Report | CureHunter
isotetrandrine drug combination cycleanine cepharanthine berbamine: an extract consisting of cepharanthine, cycleanine, isotetrandrine, and berbamine; isolated from Stephania cepharantha
http://www.curehunter.com/public/keywordSummaryC455110-isotetrandrine-drug-combination-cycleanine-cepharanthine-berbamine.do
Ingredient InformationIngredient Information
Cardiac effects of the extract and active components of radix stephaniae tetrandrae. II. Myocardial infarct, arrhythmias, coronary arterial flow and heart rate in the isolated perfused rat heart ...
http://sw16.im.med.umich.edu/chmis-c/ingredient/showIngredient.jsp?ID=568&order=0
Ingredient InformationIngredient Information
Cardiac effects of the extract and active components of radix stephaniae tetrandrae. II. Myocardial infarct, arrhythmias, coronary arterial flow and heart rate in the isolated perfused rat heart ...
http://sw16.im.med.umich.edu/chmis-c/ingredient/showIngredient.jsp?ID=369
Get PDF - In vitro and in vivo effect of paclitaxel and cepharanthine co-loaded polymeric nanoparticles in gastric cancerGet PDF - In vitro and in vivo effect of paclitaxel and cepharanthine co-loaded polymeric nanoparticles in gastric cancer
Yu, H-Hua.; Mi, W-Ning.; Liu, B.; Zhao, H-Peng., 2016: In vitro and in vivo effect of paclitaxel and cepharanthine co-loaded polymeric nanoparticles in gastric cancer
https://eurekamag.com/research/058/085/058085315.php
FacultyFaculty
Biot-Pelletier,D., V.J.J. Martin. 2016. Seamless and site-directed mutagenesis of the Saccharomycescerevisae genome using CRISPR-Cas9. Journal of Biological Engineering. InPress.. Payne, M., L. Narcross, E.Fossati, L. Bourgeois and V.J.J. Martin.2016. Reconstituting plant secondarymetabolism in Saccharomyces cerevisiaefor production of high-value benzylisoquinoline alkaloids. Methods inEnzymology. In Press. Online 10 March 2016. Campbell, A., P.Bauchart, N.D. Gold, Y. Zhu, V. de Luca and V.J.J. Martin. 2016.Engineering of a nepetalactol-producing platform strain of Saccharomycescerevisiae for the production of seco-iridoids. ACS Synthetic Biology. Web PublicationDate: March 16, 2016. Larue, K., M. Melgarand V.J.J. Martin. 2016. Directed evolution of a fungal β-glucosidase in Saccharomyces cerevisiae. Biotechnology for Biofuels. 9:52. Narcross, L, E. Fossati, L. Bourgeois and V J.J. Martin. 2016.Microbial factories for the production of benzylisoquinoline alkaloids. Trendsin Biotechnology. ...
http://www.concordia.ca/artsci/biology/faculty.html.html?fpid=vincent-martin
Abstract 275: Berbamine Confers Cardioprotection Against Ischemia-Reperfusion Injury by Attenuating Ca2+ Overload and...Abstract 275: Berbamine Confers Cardioprotection Against Ischemia-Reperfusion Injury by Attenuating Ca2+ Overload and...
Reperfusion is an essential treatment to salvage ischemia myocardium from necrosis. However, the reperfusion can also lead to additional damage. Ischemic preconditioning is a powerful way to initiate intrinsic adaptive responses protecting the heart from subsequent severe ischemia/reperfusion (I/R) injury that can be mimicked by pharmacological preconditioning. However, so far few agents are clinically available for patients with ischemia heart disease. There is a growing interest in exploring effective cardioprotective components extracted from Traditional Chinese Medicine because they have been practiced for thousands of years, providing a vast source of pharmaceutical materials. Berbamine, a kind of bisbenzylisochinoline alkaloids derived from the roots, barks and stems of Barberry, was reported to protect myocardium from ischemia/reperfusion (I/R) injury, but the underlying mechanisms are largely unknown. Here, we investigated whether berbamine confers cardioprotection via preventing calpain ...
http://circres.ahajournals.org/content/111/Suppl_1/A275
What is Ebb and Flow? - Definition from MaximumYieldWhat is Ebb and Flow? - Definition from MaximumYield
Ebb and Flow Definition - An ebb and flow system, also known as a flood and drain system, is a popular hydroponic growing system where theres an...
https://www.maximumyield.com/definition/2708/ebb-and-flow
Ebb Tide Oceanfront Inn (Seaside, OR) - Motel Reviews, Photos & Price Comparison - TripAdvisorEbb Tide Oceanfront Inn (Seaside, OR) - Motel Reviews, Photos & Price Comparison - TripAdvisor
Now £67 (Was £̶8̶3̶) on TripAdvisor: Ebb Tide Oceanfront Inn, Seaside. See 1,128 traveller reviews, 348 candid photos, and great deals for Ebb Tide Oceanfront Inn, ranked #12 of 27 hotels in Seaside and rated 4 of 5 at TripAdvisor.
https://www.tripadvisor.co.uk/Hotel_Review-g52061-d96193-Reviews-or100-Ebb_Tide_Oceanfront_Inn-Seaside_Oregon.html
Demi Moore Booking Agency Booking Demi Moore For Private & Corporate Events - Contact An Demi Moore Agent NowDemi Moore Booking Agency Booking Demi Moore For Private & Corporate Events - Contact An Demi Moore Agent Now
Contact an Demi Moore booking agent now to discuss pricing & fees with an Demi Moore agent to book Demi Moore for corporate events, private parties & public concerts worldwide.
http://onlinetalent.com/artist/celebrities/Demi-Moore.php
SchutzV1, Main, Exploration, indexItem, RBID.i, ISTEX:EAB38297E082617CBDDA5554499EBB71ED20D3D5SchutzV1, Main, Exploration, indexItem, RBID.i, ISTEX:EAB38297E082617CBDDA5554499EBB71ED20D3D5
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i \ -Sk ISTEX:EAB38297E082617CBDDA5554499EBB71ED20D3D5 \ , HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd ...
https://lorexplor.istex.fr/Wicri/Musique/explor/SchutzV1/Site/fr/Main/Exploration/indexItem.php?index=RBID.i&key=ISTEX%3AEAB38297E082617CBDDA5554499EBB71ED20D3D5
John Rothery, Director of Finance - Axon Moore : Axon MooreJohn Rothery, Director of Finance - Axon Moore : Axon Moore
When considering the relocation of our finance team (c.20 FTE,) Axon Moore were recommended as a source of advice and market knowledge. The combination of finance expertise, in-depth knowledge of talent and understanding of culture & team dynamics was unique and allowed us to almost completely delegate recruitment, freeing up time to focus on process and system improvement and the successful delivery of the relocation. We continue to work with Axon Moore exclusively and would now consider them a key strategic partner.. ...
http://www.axonmoore.com/testimonials/john-rothery-director-of-finance-2/
Demi Moore claims Ashton Kutcher cheated twice and pressured her into threesomes - Mirror OnlineDemi Moore claims Ashton Kutcher cheated twice and pressured her into threesomes - Mirror Online
Demi Moore has opened up about life with ex husband Ashton Kutcher and claims he pressured her into having two threesomes which she regretted
https://www.mirror.co.uk/3am/celebrity-news/demi-moore-claims-ashton-kutcher-20105534?fbclid=IwAR2v_sw2R4f_ObMpAYweymnzmHvbDduATgf0nytbFI44R-nsAMD79vNckNY
Moore marks 40 years at Napa Sew & Vac | Business | napavalleyregister.comMoore marks 40 years at Napa Sew & Vac | Business | napavalleyregister.com
Napa Sew & Vac has reached 40 years in business this year, a landmark that came despite many hardship and trials over the years for owner Russell Moore.
https://napavalleyregister.com/business/moore-marks-40-years-at-napa-sew-vac/article_a18df0b2-277f-52ab-bf03-a996a419dcd6.html
Neferine from Nelumbo nucifera induces autophagy through the inhibition of PI3K/Akt/mTOR pathway and ROS hyper generation in...Neferine from Nelumbo nucifera induces autophagy through the inhibition of PI3K/Akt/mTOR pathway and ROS hyper generation in...
TY - JOUR. T1 - Neferine from Nelumbo nucifera induces autophagy through the inhibition of PI3K/Akt/mTOR pathway and ROS hyper generation in A549 cells. AU - Poornima, Paramasivan. AU - Weng, Ching Feng. AU - Padma, Viswanadha Vijaya. PY - 2013/12/15. Y1 - 2013/12/15. N2 - Previously we have reported that neferine from the medicinal plant Nelumbo nucifera, inhibited cancer cell proliferation by inducing apoptosis. The present study was focused on the action mechanism of neferine in inducing autophagy in lung cancer cells. Neferine markedly inhibited A549 cell proliferation in a dose dependent manner. Acidic vesicular accumulation was observed in neferine treated cells as an indication of autophagy. Neferine could induce the conversion of LC3B-I to LC3B-II without affecting the expression levels of PI3KCIII and Beclin1. It has been observed that neferine mediated autophagy is dependent on inhibition of PI3K/Akt/mTOR signaling by neferine. Neferine treatment could also lead to the ROS ...
https://rke.abertay.ac.uk/en/publications/neferine-from-nelumbo-nucifera-induces-autophagy-through-the-inhi
Bisbenzylisoquinoline alkaloids from Stephania cepharantha and their effects on proliferation of cultured cells from the murine...Bisbenzylisoquinoline alkaloids from Stephania cepharantha and their effects on proliferation of cultured cells from the murine...
Bisbenzylisoquinoline alkaloids were isolated from Stephania cepharantha Hayata and their proliferative activities on cultured hair cells from the murine skin were evaluated. Cepharanthine (1), cepharanoline (9), isotetrandrine (2), and berbamine (7) showed significant activities in the range of 0.01-0.1 microgram/ml, but had no activity on cultured keratinocytes or fibroblasts from the murine skin.
https://www.semanticscholar.org/paper/Bisbenzylisoquinoline-alkaloids-from-Stephania-cep-Nakaoji-Nayeshiro/b897297f2ee723165eacd63b3b2302f2620e7acb
AID 680711 - TP TRANSPORTER: increase in Rhodamine 123 intracellular accumulation (R123: 4 uM, Fangchinoline: 3 uM) in HCT15...AID 680711 - TP TRANSPORTER: increase in Rhodamine 123 intracellular accumulation (R123: 4 uM, Fangchinoline: 3 uM) in HCT15...
BioAssay record AID 680711 submitted by ChEMBL: TP_TRANSPORTER: increase in Rhodamine 123 intracellular accumulation (R123: 4 uM, Fangchinoline: 3 uM) in HCT15 cells.
https://pubchem.ncbi.nlm.nih.gov/bioassay/680711
UNTHSC Scholarly Repository - Research Appreciation Day: TETRANDRINE INDUCED INHIBITION OF SIGNAL TRANSDUCER AND ACTIVATOR OF...UNTHSC Scholarly Repository - Research Appreciation Day: TETRANDRINE INDUCED INHIBITION OF SIGNAL TRANSDUCER AND ACTIVATOR OF...
Natural agents may be promising to combat aggressive behavior of the triple-negative breast cancer (TNBC). STAT3 is a protein that is highly expressed in breast cancer tissues compared to non-malignant breast tissues. Our objective for the present study is to analyze the anti-tumorogenic effects of a Chinese herbal drug, tetrandrine, in TNBC progression through inhibition of STAT3 phosphorylation.
https://digitalcommons.hsc.unt.edu/rad/RAD14/Cancer/12/
Toxins | Free Full-Text | Curine Inhibits Macrophage Activation and Neutrophil Recruitment in a Mouse Model of...Toxins | Free Full-Text | Curine Inhibits Macrophage Activation and Neutrophil Recruitment in a Mouse Model of...
Curine is a bisbenzylisoquinoline alkaloid (BBA) with anti-allergic, analgesic, and anti-inflammatory properties. Previous studies have demonstrated that this alkaloid is orally active at non-toxic doses. However, the mechanisms underlying its anti-inflammatory effects remain to be elucidated. This work aimed to investigate the effects of curine on macrophage activation and neutrophil recruitment. Using a murine model of lipopolysaccharide (LPS)-induced pleurisy, we demonstrated that curine significantly inhibited the recruitment of neutrophils in association with the inhibition of cytokines tumor necrosis factor (TNF-α), interleukin (IL)-1β, IL-6, monocyte chemotactic protein (CCL2/MCP-1) as well as leukotriene B4 in the pleural lavage of mice. Curine treatment reduced cytokine levels and the expression of iNOS in in vitro cultures of macrophages stimulated with LPS. Treatment with a calcium channel blocker resulted in comparable inhibition of TNF-α and IL-1β production, as well
https://www.mdpi.com/2072-6651/11/12/705
The eutardigrade Thulinia stephaniae has an indeterminate development and the potential to regulate early blastomere ablations ...The eutardigrade Thulinia stephaniae has an indeterminate development and the potential to regulate early blastomere ablations ...
When DArcy Wentworth Thompsons On Growth and Form was published 100 years ago, it raised the question of how biological forms arise during development and across evolution. In light of the advances in molecular and cellular biology since then, a succinct modern view of the question states: how do genes encode geometry? Our new special issue is packed with articles that use mathematical and physical approaches to gain insights into cell and tissue patterning, morphogenesis and dynamics, and that provide a physical framework to capture these processes operating across scales.. Read the Editorial by guest editors Thomas Lecuit and L. Mahadevan, as they provide a perspective on the influence of DArcy Thompsons work and an overview of the articles in this issue.. ...
http://dev.biologists.org/content/early/2005/02/16/dev.01701
CAS 118-08-1 (1R,9S)-(-)-β-Hydrastine - BOC SciencesCAS 118-08-1 (1R,9S)-(-)-β-Hydrastine - BOC Sciences
Boc Sciences offers cas 118-08-1 (1R,9S)-(-)-β-Hydrastine in bulk,please inquire us to get a quote for 118-08-1 (1R,9S)-(-)-β-Hydrastine.
http://www.bocsci.com/1r-9s-hydrastine-cas-118-08-1-item-474374.html
Tom Moore - IMDbTom Moore - IMDb
Tom Moore, Producer: Return to Boggy Creek. Tom Moore is a retired American film writer, producer, and director. Moore produced and directed more than a hundred TV commercials and multi-episode video series, but is best know for Return to Boggy Creek (1977). Moore worked in the Texas area with Director Charlie Pierce as a Line Producer on four films. The two met each other while working at a small TV station in El Dorado, Arkansas. Moore ...
http://www.imdb.com/name/nm1504321/?ref_=tt_ov_dr
From the Dust Returned: Howls of Ebb InterviewFrom the Dust Returned: Howls of Ebb Interview
When launching this site six years ago, my original intention was not only to write up critiques on a comprehensive body of metal works, but also to converse with the creators behind some of the most compelling and inspirational of recordings Ive encountered through my listening. Well, as the months (and years) rolled on, I really failed to launch on this aspect, finding it difficult to dig up the investment I had in the 90s when writing for a print zine. That all changes this Spring, as I embark on a monthly quest to pick the brains of some of the more fascinating authors of agony in the underground! Who better to start this with than the esoteric consciousness behind the Howls of Ebb, whose debut album through I, Voidhanger records has spent several nights with me on the very precipice of sanity...I was honored to speak with songwriter, vocalist and guitarist Z.L.H.. ...
http://autothrall.blogspot.com/2014/04/howls-of-ebb-interview.html
C3EBB0 html color codeC3EBB0 html color code
Information on the #C3EBB0 html color code with its RGB and HSL make up, lighter and darker colors, analogous colors, and trinary colors.
https://www.computerhope.com/cgi-bin/htmlcolor.pl?c=C3EBB0
O.L.D. - Ebb lyrics | LyricsMode.comO.L.D. - Ebb lyrics | LyricsMode.com
Ebb lyrics by O.L.D.: Now I see / What I hate / Now I hate / What I see / See myself and what I hate / Now I hate / What I see / All must
http://www.lyricsmode.com/lyrics/o/old/ebb.html
Demi Moore Hospitalized, Seeking Professional Assistance | Demi Moore : Just JaredDemi Moore Hospitalized, Seeking Professional Assistance | Demi Moore : Just Jared
Demi Moore Hospitalized, Seeking Professional Assistance Demi Moore is seeking professional assistance after being rushed to the hospital on Monday night (January 23). Paramedics responded to the 49-year-old actresss…
http://www.justjared.com/2012/01/24/demi-moore-hospitalized-seeking-professional-assistance/
Mountain and Sea Scotland: All in the timing at the Gulf of CorryvreckanMountain and Sea Scotland: All in the timing at the Gulf of Corryvreckan
The narrowest part of the channel is less than 2km long, but takes a huge volume of water through on each tide. We reckoned that the actual slack water was less than five minutes before we began to feel the insistent pull of the ebb drawing us into the narrows. A few swirls and hydraulic cushions began to appear as the ebb started to establish but in the absence of swell things were very gentle ...
http://mountainandseascotland.blogspot.co.uk/2017/07/all-in-timing-at-gulf-of-corryvreckan.html
Queens Ledger - Christina Moore Ms BrooklynQueens Ledger - Christina Moore Ms Brooklyn
Christina Moore Ms. Brooklyn - Five frenzied months into her reign as Miss Brooklyn Christina Moore is showing no signs of slowing down- or scaling back her hometown pride.
http://www.queensledger.com/view/full_story/11317101/article-Christina-Moore--Ms--Brooklyn?instance=lead_story_left_column
Moore & Wright MW3318 Firm Joint Outside Caliper | StaplesMoore & Wright MW3318 Firm Joint Outside Caliper | Staples
Shop Moore & Wright MW3318 Firm Joint Outside Caliper at Staples. Choose from our wide selection of Moore & Wright MW3318 Firm Joint Outside Caliper and get fast & free shipping on select orders.
https://www.staples.com/Moore-Wright-MW3318-Firm-Joint-Outside-Caliper/product_154487
Patrick Moore on nuclear safety | Greenpeace PhilippinesPatrick Moore on nuclear safety | Greenpeace Philippines
Recently Congressman Mark Cojuangco has been quoting Moore, on the issue of nukes and I was wondering if had he not been formerly a part of Greenpeace would his opinion on the issue still count?. I recently stumbled upon this quote from Patrick Moore: ...
http://www.greenpeace.org/seasia/ph/News/greenpeace-philippine-blog/patrick-moore-on-nuclear-safety/blog/13111/
Zoetica Ebb - your oxygen?Zoetica Ebb - your oxygen?
Model Mayhem is the #1 portfolio website for professional models and photographers. Create a profile, upload your photos and connect with other professionals
https://www.modelmayhem.com/portfolio/pic/464837
Leah Velocity - sinful math, the ebb and flow to multiply.Leah Velocity - sinful math, the ebb and flow to multiply.
Model Mayhem is the #1 portfolio website for professional models and photographers. Create a profile, upload your photos and connect with other professionals
https://www.modelmayhem.com/portfolio/pic/23544905
Ebb and flow - the result of the rotation of the Earth and gyres | Page 16 | Naked Science ForumEbb and flow - the result of the rotation of the Earth and gyres | Page 16 | Naked Science Forum
Tides are not formed along the entire coast of the seas and oceans, but only on those coasts with a high speed of currents. And the higher the speed of curre...
https://www.thenakedscientists.com/forum/index.php?topic=73127.msg553390
Ebb and flow - the result of the rotation of the Earth and gyres | Page 5 | Naked Science ForumEbb and flow - the result of the rotation of the Earth and gyres | Page 5 | Naked Science Forum
Tides are not formed along the entire coast of the seas and oceans, but only on those coasts with a high speed of currents. And the higher the speed of curre...
https://www.thenakedscientists.com/forum/index.php?topic=73127.msg542070
2018 Survivor Profile - Dawn Moore | Newsday2018 Survivor Profile - Dawn Moore | Newsday
Dawn Moore, Hampton Bays mother of two, is a self-described poster child for the early detection of breast cancer. I have met so many women who are over 40, even a doctor friend of mine, who have n
https://www.newsday.com/services/programs/life-s-victories/2018-survivor-profile-dawn-moore-1.22393125
Tissue Paper Covered Leaf | A.C. MooreTissue Paper Covered Leaf | A.C. Moore
Check out Tissue Paper Covered Leaf crafting ideas at A.C. Moore. Explore many more such exceptional art & craft products only here.
http://www.acmoore.com/tissue-paper-covered-leaf.html
Moore to lead in the same vein | West Bromwich AlbionMoore to lead in the same vein | West Bromwich Albion
DARREN Moore says he will begin his reign as Albion Head Coach in the same vein he approached the final six games of last season.
https://www.wba.co.uk/news/2018/june/moore-to-lead-in-the-same-vein
PC Networking & Moore: Shinnston, WV Managed IT Services - SpiceworksPC Networking & Moore: Shinnston, WV Managed IT Services - Spiceworks
I have been doing IT work for both residential and businesses for about 20 years. I recently started PC Networking & Moore in order to help provide support and expertise i...
https://community.spiceworks.com/service-providers/47225-pc-networking-moore
Moore Regional Hospital sets record for babies during August 2011 | FirstHealthMoore Regional Hospital sets record for babies during August 2011 | FirstHealth
With 168 deliveries and 170 babies (84 girls and 86 boys that included two sets of twins), Moore Regional broke the previous record of 166 deliveries that was set in 2009.
https://www.firsthealth.org/lifestyle/news-events/2011/09/moore-regional-hospital-sets-record-for-babies-during-august-2011
Education and Training | Moore MedicalEducation and Training | Moore Medical
Moore Medical offers a variety of education and training materials including anatomical charts and models, manikins and simulators, reference and field guides and more.
https://www.mooremedical.com/index.cfm?/Education-Training/&No=0&Nao=0&N=89&Ns=TotalRevenue%7C1&spx=1&CFID=118502519&CFTOKEN=97285990
Education and Training | Moore MedicalEducation and Training | Moore Medical
Moore Medical offers a variety of education and training materials including anatomical charts and models, manikins and simulators, reference and field guides and more.
https://www.mooremedical.com/index.cfm?/Education-Training/&No=0&N=89&Ns=TotalRevenue%7C1&spx=1&CFID=118502519&CFTOKEN=97285990
Michael Moore has done it again.Michael Moore has done it again.
Heres a video from Michael Moore, you know that fat film maker that gets grants from US to make films breading hate and discontent. Thought you all might like to see it. Because it made my neck hairs stand up. http://www.theblaze.com/stories/michael-moore-people-own-guns-because-theyre-fearful-racists/
http://forum.opencarry.org/forums/showthread.php?85718-Michael-Moore-has-done-it-again
collection marj moore | Ace & Tatecollection marj moore | Ace & Tate
If youre searching for modern streetwear style inspiration with a 90s edge, look no further than Marj Moore. Use code __ATMKT5X10-7RNYFN-OCT2020__ to get €10,- off your order. [__Read our terms & conditions here |__](https://www.aceandtate.com/gb/legal/raf-curated-by-marketing-terms-and-conditions)
https://www.aceandtate.com/de-en/collection/curated-by-marj-moore
Burning The Sky by Pat Moore |...Burning The Sky by Pat Moore |...
Buy Burning The Sky by Pat Moore as a Poster, Throw Pillow, Tote Bag, Art Print, Canvas Print, Framed Print, Photographic Print, Metal Print, or Greeting Card
https://www.redbubble.com/people/madampatm/works/1411992-burning-the-sky
Paparazzo Files Battery Report Against Demi Moore! | PerezHilton.comPaparazzo Files Battery Report Against Demi Moore! | PerezHilton.com
Demi Moore cannot catch a break! A photographer has filed a battery report against the actress, after he claimed that she struck him as he tried to snap some...
http://perezhilton.com/2011-10-29-paparazzo-files-battery-report-against-demi-moore/
ARTFINDER: Fire N Ice by Lucy Moore - I will ship Globally but please message me for a price I am very Proud of this piece...ARTFINDER: Fire N Ice by Lucy Moore - I will ship Globally but please message me for a price I am very Proud of this piece...
ARTFINDER: Fire N Ice by Lucy Moore - I will ship Globally but please message me for a price I am very Proud of this piece of art work, the photographs dont do this piece any justice. This...
https://www.pinterest.com/pin/281123201716569249/
Christy Moore (respiratory03) on PinterestChristy Moore (respiratory03) on Pinterest
See what Christy Moore (respiratory03) has discovered on Pinterest, the worlds biggest collection of everybodys favorite things.
https://www.pinterest.com/respiratory03/
Demi Moore Missing Her Top Two TeethDemi Moore Missing Her Top Two Teeth
Dont worry, were just as shocked as you are! Demi Moore shared a photo of her missing her two teeth and explains just how they fell out.
https://www.hotmomsclub.com/demi-moore-reveals-shes-missing-her-two-front-teeth-and-how-they-fell-out-is-scary/
Carbon Nation - VarietyCarbon Nation - Variety
Carbon Nation Carbon Nation generates such an ebb and flow between predictions of doom and a green, sustainable future that the resulting wave power could sustain a small city.
http://variety.com/2011/film/reviews/carbon-nation-1117944319/
In My Humble Opinion: August 2011In My Humble Opinion: August 2011
And we learned...Cameron and I. Over months he began to adjust to the weight of the bow, the tension of the strings. I stood over him. I listened to the plink and pluck, the ebb and flow. At times picking up the miniature violin and instructing on what I perceived to be the right stance. I moved the bow back and forth awkwardly my body curled to meet the requirements of such a small instrument ...
http://jordan-inmyhumbleopinion.blogspot.ie/2011/08/
aside post format | Caner Arasaside post format | Caner Aras
A Story About Nothing Responsive web design offers us a way forward, finally allowing us to design for the ebb and flow of things.There are many variations of
http://caneraras.com/aside-post-format/
Guess what Michael Moores Trumpileaks site is about | EngadgetGuess what Michael Moores Trumpileaks site is about | Engadget
Michael Moore just created a new website called Trumpileaks, for, you guessed it, collecting leaked information about Trump administration activities. In a letter posted on the site, Moore implored, I need one of you to help me. It might get dangerous. It may get us in trouble. But were running out of time.
https://www.engadget.com/2017-06-06-michael-moore-trumpileaks-launch.html
Ellen Moore - Art Of ManagementEllen Moore - Art Of Management
Ellen enjoys working with our clients as they strive to provide their patients with the best care possible. She has a deep respect for those who dedicate their lives to improving the lives of others. She is honoured to be in a position where she can help them do that to their fullest potential.. ...
http://amican.com/team_member/ellen-moore/
The Real World: Go Big Or Go Home - Dylan Moore | VevmoThe Real World: Go Big Or Go Home - Dylan Moore | Vevmo
I kinda like him. Because I think hed be a solid competitor. As a person hes eh not terrible, the best one of the gbogh guys but the bar is already so so so low ...
http://vevmo.com/comment/2191088
LaudanosineLaudanosine
Burger A (2005) [1954]. "The Benzylisoquinoline Alkaloids". In Manske RH, Holmes HL (eds.). The Alkaloids: Chemistry and ...
https://en.wikipedia.org/wiki/Laudanosine
XylopineXylopine
... is an antimicrobial benzylisoquinoline alkaloid. Villar, A; Mares, M; Rios, JL; Canton, E; Gobernado, M (1987). " ... "Antimicrobial activity of benzylisoquinoline alkaloids". Die Pharmazie. 42 (4): 248-50. PMID 3615557. v t e. ...
https://en.wikipedia.org/wiki/Xylopine
Tubocurarine chlorideTubocurarine chloride
Structurally, tubocurarine is a benzylisoquinoline derivative. For many years, its structure, when first elucidated in 1948, ...
https://en.wikipedia.org/wiki/Tubocurarine_chloride
Nelumbo nuciferaNelumbo nucifera
The plant also contains nuciferine, neferine and many other benzylisoquinoline alkaloids with medicinal properties. All parts ... Menendez-Perdomo, I. M. and P. J. Facchini (2018). "Benzylisoquinoline Alkaloids Biosynthesis in Sacred Lotus." Molecules 23(11 ... "Anti-HIV benzylisoquinoline alkaloids and flavonoids from the leaves of Nelumbo nucifera, and structure-activity correlations ... "Isolation and characterization of two O-methyltransferases involved in benzylisoquinoline alkaloid biosynthesis in sacred lotus ...
https://en.wikipedia.org/wiki/Nelumbo_nucifera
Computational Resource for Drug DiscoveryComputational Resource for Drug Discovery
BIAdb: A Database for Benzylisoquinoline Alkaloids. The Benzylisoquinoline Alkaloid Database is an attempt to gather the ... A curated database of benzylisoquinoline alkaloids". BMC Pharmacology. 10: 4. doi:10.1186/1471-2210-10-4. PMC 2844369. PMID ...
https://en.wikipedia.org/wiki/Computational_Resource_for_Drug_Discovery
Atracurium besilateAtracurium besilate
McCorkindale NJ, Magrill DS, Martin-Smith M, Smith SJ, Stenlake JB (1964). "Petaline: A 7,8-dioxygenated benzylisoquinoline". ...
https://en.wikipedia.org/wiki/Atracurium_besilate
HigenamineHigenamine
Hagel JM, Facchini PJ (May 2013). "Benzylisoquinoline alkaloid metabolism: a century of discovery and a brave new world". Plant ... S)-Norcoclaurine/Higenamine is at the center of benzylisoquinoline alkaloid (BIA) biosynthesis. In spite of large structure ... Beaudoin GA, Facchini PJ (July 2014). "Benzylisoquinoline alkaloid biosynthesis in opium poppy". Planta. 240 (1): 19-32. doi: ... "Anti-HIV benzylisoquinoline alkaloids and flavonoids from the leaves of Nelumbo nucifera, and structure-activity correlations ...
https://en.wikipedia.org/wiki/Higenamine
Morphinone reductaseMorphinone reductase
"Microbial production of plant benzylisoquinoline alkaloids". Proceedings of the National Academy of Sciences. 105 (21): 7393- ...
https://en.wikipedia.org/wiki/Morphinone_reductase
FungusFungus
Hawkins KM, Smolke CD (September 2008). "Production of benzylisoquinoline alkaloids in Saccharomyces cerevisiae". Nature ...
https://en.wikipedia.org/wiki/Fungus
S)-norcoclaurine synthaseS)-norcoclaurine synthase
The first committed enzyme in benzylisoquinoline alkaloid biosynthesis in plants". J. Biol. Chem. 277 (37): 33878-83. doi: ... Stadler R, Kutchan TM, Zenk MH (1989). "(S)-Norcoclaurine is the central intermediate in benzylisoquinoline alkaloid ... This enzyme participates in benzylisoquinoline alkaloid biosynthesis. Stadler R, Zenk MH (1990). "A revision of the generally ...
https://en.wikipedia.org/wiki/(S)-norcoclaurine_synthase
ReticulineReticuline
It is based on the benzylisoquinoline structure. Reticuline is one of the alkaloids found in opium, and experiments in rodents ...
https://en.wikipedia.org/wiki/Reticuline
Isoquinoline alkaloidsIsoquinoline alkaloids
The most common structural types are the benzylisoquinolines and the aporphines. According to current knowledge, a total of ...
https://en.wikipedia.org/wiki/Isoquinoline_alkaloids
SanguinariaSanguinaria
Bloodroot produces benzylisoquinoline alkaloids, primarily the toxin sanguinarine. The alkaloids are transported to and stored ... also produce such benzylisoquinoline alkaloids. Plant geneticists have identified and sequenced genes which produce the enzymes ...
https://en.wikipedia.org/wiki/Sanguinaria
Papaver somniferumPapaver somniferum
2019). "Benzylisoquinoline alkaloid biosynthesis in opium poppy: an update." Phytochem Rev 18(6): 1457-1482 Menéndez-Perdomo I. ... which carries the benzylisoquinoline skeleton that gives its name to this pathway. The conversion of (S) -norcoclaurin to (S) - ... M., Hagel J.M. and Facchini P.J. (2021). "Benzylisoquinoline alkaloid analysis using high-resolution Orbitrap LC-MSn." J Mass ... synthesized through the metabolic pathway of benzylisoquinoline. First, the amino acid phenylalanine, through the enzyme ...
https://en.wikipedia.org/wiki/Papaver_somniferum
CanadineCanadine
It is also an intermediate in the complex biosynthesis of noscapine, which is likewise a benzylisoquinoline alkaloid, but of ... S)-Canadine, also known as (S)-tetrahydroberberine and xanthopuccine, is a benzylisoquinoline alkaloid (BIA), of the ... "Transcriptome analysis of 20 taxonomically related benzylisoquinoline alkaloid-producing plants". BMC Plant Biology. 15: 227. ...
https://en.wikipedia.org/wiki/Canadine
TetrandrineTetrandrine
... , a bis-benzylisoquinoline alkaloid, is a calcium channel blocker. It has anti-inflammatory, immunologic and ... Kwan, C. Y.; Achike, F. I. (2002). "Tetrandrine and related bis-benzylisoquinoline alkaloids from medicinal herbs: ... Kwan, C. Y.; Achike, F. I. (2002). "Tetrandrine and related bis-benzylisoquinoline alkaloids from medicinal herbs: ...
https://en.wikipedia.org/wiki/Tetrandrine
ScoulerineScoulerine
... , also known as discretamine and aequaline, is a benzylisoquinoline alkaloid (BIA) that is derived directly from (S)- ... "Transcriptome analysis of 20 taxonomically related benzylisoquinoline alkaloid-producing plants". BMC Plant Biology. 15: 227. ...
https://en.wikipedia.org/wiki/Scoulerine
ProtopineProtopine
... is metabolically derived from the benzylisoquinoline alkaloid (S)-Reticuline through a progressive series of five ... "Transcriptome analysis of 20 taxonomically related benzylisoquinoline alkaloid-producing plants". BMC Plant Biology. 15: 227. ...
https://en.wikipedia.org/wiki/Protopine
CheilanthifolineCheilanthifoline
S)-Cheilanthifoline is a benzylisoquinoline alkaloid (BIA) which has been isolated from Corydalis dubia and Argemone mexicana.[ ... "Transcriptome analysis of 20 taxonomically related benzylisoquinoline alkaloid-producing plants". BMC Plant Biology. 15: 227. ...
https://en.wikipedia.org/wiki/Cheilanthifoline
BBE-like enzymesBBE-like enzymes
Also, marks a branch point in the biosynthesis of benzylisoquinoline alkaloids. As mentioned above, BBE-like enzymes are in the ...
https://en.wikipedia.org/wiki/BBE-like_enzymes
Aristolochic acidAristolochic acid
... or related benzylisoquinoline precursors, which in turn are derived from tyrosine (2). Feeding studies (Aristolochia sipho) ... The first enzyme in the benzylisoquinoline biosynthetic pathway". FEBS Letters. 129: 5-9. doi:10.1016/0014-5793(81)80742-9. ...
https://en.wikipedia.org/wiki/Aristolochic_acid
LauraceaeLauraceae
Benzylisoquinoline alkaloids include aporphines and oxoaporphines, as well as derivatives of morphinans. Essential oils include ...
https://en.wikipedia.org/wiki/Lauraceae
MorphineMorphine
... is a benzylisoquinoline alkaloid with two additional ring closures.[citation needed] As Jack DeRuiter of the ...
https://en.wikipedia.org/wiki/Morphine
ChelidonineChelidonine
Benzylisoquinoline alkaloids (BIAs) are a structurally diverse group of plant specialized metabolites with a long history of ... Hagel, J. M, & Facchini, P. J. (2013). Benzylisoquinoline Alkaloid Metabolism: A Century of Discovery and a Brave New World. ...
https://en.wikipedia.org/wiki/Chelidonine
IsoquinolineIsoquinoline
1-Benzylisoquinoline is the structural backbone in naturally occurring alkaloids including papaverine. The isoquinoline ring in ...
https://en.wikipedia.org/wiki/Isoquinoline
Poppy teaPoppy tea
... contains two groups of alkaloids: phenanthrenes (including morphine and codeine) and benzylisoquinolines (including ...
https://en.wikipedia.org/wiki/Poppy_tea
AminosteroidAminosteroid
Benzylisoquinolines, such as atracurium and tubocurarine, the other major group of neuromuscular blocking agents Ted Lin; Tim ...
https://en.wikipedia.org/wiki/Aminosteroid
Aporphine alkaloidsAporphine alkaloids
After the benzylisoquinoline alkaloids they are the second largest group of isoquinoline alkaloids. At least 85 aporphine ... Part V. The absolute stereochemistry of the morphine, benzylisoquinoline, aporphine, and tetrahydroberberine alkaloids". ... The aporphine alkaloids are of particular interest because of their proximity to morphine and benzylisoquinoline alkaloids. For ...
https://en.wikipedia.org/wiki/Aporphine_alkaloids
MagnoflorineMagnoflorine
S)-Magnoflorine is a quaternary benzylisoquinoline alkaloid (BIA) of the aporphine structural subgroup which has been isolated ... "Identification and Characterization of Genes Involved in Benzylisoquinoline Alkaloid Biosynthesis in Coptis Species". Front ...
https://en.wikipedia.org/wiki/Magnoflorine
Benzylisoquinoline - WikipediaBenzylisoquinoline - Wikipedia
1-Benzylisoquinolines as precursors of thebaine, codeine, and morphine". J Chem Soc: 3600. Benzylisoquinoline biosynthesis by ... the most widely examined of the numerous benzylisoquinoline structural isomers. The 1-benzylisoquinoline moiety can be ... Hagel, Jillian M; Facchini, Peter J (2013). "Benzylisoquinoline alkaloid metabolism: A century of discovery and a brave new ... Substitution of the heterocycle isoquinoline at the C1 position by a benzyl group provides 1‑benzylisoquinoline, ...
https://en.wikipedia.org/wiki/Benzylisoquinoline
Benzylisoquinolines | definition of benzylisoquinolines by Medical dictionaryBenzylisoquinolines | definition of benzylisoquinolines by Medical dictionary
What is benzylisoquinolines? Meaning of benzylisoquinolines medical term. What does benzylisoquinolines mean? ... Looking for online definition of benzylisoquinolines in the Medical Dictionary? benzylisoquinolines explanation free. ... benzylisoquinolines. ben·zyl·i·so·quin·o·lines. (benzil-īsō-kwinō-linz), A group of alkaloids found primarily in poppy ... Selective inhibition of calcium entry induced by benzylisoquinolines in rat smooth muscle was studied (Catret et al. ...
http://medical-dictionary.thefreedictionary.com/benzylisoquinolines
Comparative analysis of transcription factor gene families from Papaver somniferum: identification of regulatory factors...Comparative analysis of transcription factor gene families from Papaver somniferum: identification of regulatory factors...
... known for biosynthesis of several therapeutically important benzylisoquinoline alkaloids (BIAs), has emerged as the premier ... Beaudoin GAW, Facchini PJ (2014b) Benzylisoquinoline alkaloid biosynthesis in opium poppy. Planta 240:19-32CrossRefPubMedGoogle ... Benzylisoquinoline alkaloids Biosynthetic pathway Cultivars Papaver somniferum Transcription factors Transcriptome data ... Beaudoin GA, Facchini PJ (2014a) Benzylisoquinoline alkaloid biosynthesis in opium poppy. Plant J 240:19-32CrossRefGoogle ...
https://link.springer.com/article/10.1007%2Fs00709-015-0848-8
Mechanistic studies on norcoclaurine synthase of benzylisoquinoline alkaloid biosynthesis: An enzymatic Pictet-Spengler...Mechanistic studies on norcoclaurine synthase of benzylisoquinoline alkaloid biosynthesis: An enzymatic Pictet-Spengler...
This is the first committed step in the biosynthesis of the benzylisoquinoline alkaloids that include morphine and codeine. In ... Mechanistic studies on norcoclaurine synthase of benzylisoquinoline alkaloid biosynthesis: An enzymatic Pictet-Spengler ... Mechanistic studies on norcoclaurine synthase of benzylisoquinoline alkaloid biosynthesis: An enzymatic Pictet-Spengler ... Mechanistic studies on norcoclaurine synthase of benzylisoquinoline alkaloid biosynthesis: An enzymatic Pictet-Spengler ...
https://www.chem.ubc.ca/mechanistic-studies-norcoclaurine-synthase-benzylisoquinoline-alkaloid-biosynthesis-enzymatic-pictet
Calabadion:A New Agent to Reverse the Effects of Benzylisoquinoline and Steroidal Neuromuscular-blocking Agents |...Calabadion:A New Agent to Reverse the Effects of Benzylisoquinoline and Steroidal Neuromuscular-blocking Agents |...
Conclusion:: Calabadion 1 is a new drug for rapid and complete reversal of the effects of steroidal and benzylisoquinoline ... Calabadion 1 is an experimental agent that binds to steroidal and benzylisoquinoline neuromuscular blockers, but its in vivo ... Calabadion: A New Agent to Reverse the Effects of Benzylisoquinoline and Steroidal Neuromuscular-blocking Agents. ... Accordingly, we thought that calabadions would display excellent affinity toward both steroidal and benzyl isoquinoline NMBAs ...
http://anesthesiology.pubs.asahq.org/article.aspx?articleid=1918255
Mechanism-based tuning of insect 3,4-dihydroxyphenylacetaldehyde synthase for synthetic bioproduction of benzylisoquinoline...Mechanism-based tuning of insect 3,4-dihydroxyphenylacetaldehyde synthase for synthetic bioproduction of benzylisoquinoline...
Mechanism-based tuning of insect 3,4-dihydroxyphenylacetaldehyde synthase for synthetic bioproduction of benzylisoquinoline ... a benzylisoquinoline alkaloid (BIA) precursor to opioid analgesics. In the current study, a phylogenetically distinct Bombyx ...
https://vtechworks.lib.vt.edu/handle/10919/92047
Frontiers | Phyto-Therapeutic and Nanomedicinal Approaches to Cure Alzheimers Disease: Present Status and Future Opportunities...Frontiers | Phyto-Therapeutic and Nanomedicinal Approaches to Cure Alzheimer's Disease: Present Status and Future Opportunities...
Benzylisoquinoline. Cissampelos pareira contains benzylisoquinoline that exerts nootropic activity in AD. It is a memory- ... A novel series of benzylisoquinoline derivatives have also been evaluated. The results have shown that most of the compounds ... synthesis and biological evaluation of benzylisoquinoline derivatives as multifunctional agents against Alzheimers disease. ...
https://www.frontiersin.org/articles/10.3389/fnagi.2018.00284/full
Oxazoles in Organic Chemistry. 2. Application to the Synthesis of Benzylisoquinoline Alkaloids - Fingerprint - Johns...Oxazoles in Organic Chemistry. 2. Application to the Synthesis of Benzylisoquinoline Alkaloids - Fingerprint - Johns...
2. Application to the Synthesis of Benzylisoquinoline Alkaloids. Together they form a unique fingerprint. * Sort by ...
https://jhu.pure.elsevier.com/en/publications/oxazoles-in-organic-chemistry-2-application-to-the-synthesis-of-b-2/fingerprints/
nature.com searchnature.com search
Modulation of benzylisoquinoline alkaloid biosynthesis by overexpression berberine bridge enzyme in Macleaya cordata *Peng ... Hairy root induction and benzylisoquinoline alkaloid production in Macleaya cordata *Peng Huang ... Rights & permissionsfor article Hairy root induction and benzylisoquinoline alkaloid production in ,i,Macleaya cordata,/i, . ... Rights & permissionsfor article Modulation of benzylisoquinoline alkaloid biosynthesis by overexpression berberine bridge ...
http://www.nature.com/search?author=%22Liu%20Wei%22&error=cookies_not_supported&code=770e7811-0948-49fd-b9b4-ec8e1e64a8f4
Neopinone isomerase is involved in codeine and morphine biosynthesis in opium poppy | Nature Chemical BiologyNeopinone isomerase is involved in codeine and morphine biosynthesis in opium poppy | Nature Chemical Biology
Benzylisoquinoline alkaloid analysis using high‐resolution Orbitrap LC‐MS n *Ivette M. Menéndez‐Perdomo ... Hagel, J. M. & Facchini, P. J. Benzylisoquinoline alkaloid metabolism: a century of discovery and a brave new world. Plant Cell ... Transcriptome analysis of 20 taxonomically related benzylisoquinoline alkaloid-producing plants. BMC Plant Biol. 15, 227 (2015 ... Desgagné-Penix, I. & Facchini, P. J. Systematic silencing of benzylisoquinoline alkaloid biosynthetic genes reveals the major ...
https://www.nature.com/articles/s41589-019-0247-0?error=cookies_not_supported&code=b6c1ba26-a0f7-4d4f-ad3a-aae213bd36ce
BIAdb: A curated database of benzylisoquinoline alkaloids | BMC Pharmacology | Full TextBIAdb: A curated database of benzylisoquinoline alkaloids | BMC Pharmacology | Full Text
A database of benzylisoquinoline compounds has been created, which provides comprehensive information about benzylisoquinoline ... Many benzylisoquinoline alkaloids have been reported to show therapeutic properties and to act as novel medicines. Thus it is ... This information was processed and compiled in order to create a comprehensive database of benzylisoquinoline alkaloids, called ... The current version of BIAdb contains information about 846 unique benzylisoquinoline alkaloids, with multiple entries in term ...
https://bmcpharma.biomedcentral.com/articles/10.1186/1471-2210-10-4/figures/1
The Isoquinoline Alkaloids Chemistry and Pharmacology - 1st EditionThe Isoquinoline Alkaloids Chemistry and Pharmacology - 1st Edition
Chapter 2. The Benzylisoquinolines. I. Introduction II. Degradation of Laudanosine, A Tetrahydro Benzylisoquinoline Alkaloid ... Syntheses of Spiro Benzylisoquinolines IV. The Protoberberine-,Spiro Benzylisoquinoline-,Dibenzo Cyclopent[b]- azepine ... Structural Elucidation of Takatonine, A Quaternary Benzylisoquinoline Alkaloid IV. Petaline, A Tetrahydro Benzylisoquinoline of ... Some Reactions of Benzylisoquinolines VIII. Absolute Configuration IX. Biosynthesis X. Pharmacology XI. A Possible Biochemical ...
https://www.elsevier.com/books/the-isoquinoline-alkaloids-chemistry-and-pharmacology/shamma/978-0-12-638250-1
RCSB PDB - EV1 Ligand Summary PageRCSB PDB - EV1 Ligand Summary Page
Benzylisoquinolines. *Cardiovascular Agents. *Chemical Actions and Uses. *Drugs for Functional Gastrointestinal Disorders ...
https://www.rcsb.org/ligand/EV1
Transcriptome analysis of 20 taxonomically related benzylisoquinoline alkaloid-producing plants | BMC Plant Biology | Full TextTranscriptome analysis of 20 taxonomically related benzylisoquinoline alkaloid-producing plants | BMC Plant Biology | Full Text
Benzylisoquinoline alkaloids (BIAs) represent a diverse class of plant specialized metabolites sharing a common biosynthetic ... Benzylisoquinoline alkaloid metabolism: a century of discovery and a brave new world. Plant Cell Physiol. 2013;54:647-72.View ... Production of benzylisoquinoline alkaloids in Saccharomyces cerevisiae. Nat Chem Biol. 2008;4:564-73.Google Scholar. ... Systematic silencing of benzylisoquinoline alkaloid biosynthetic genes reveals the major route to papaverine in opium poppy. ...
https://0-bmcplantbiol-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/s12870-015-0596-0
Characterization of Oxidative Enzymes Involved in the Biosynthesis of Benzylisoquinoline Alkaloids in Opium Poppy (Papaver...Characterization of Oxidative Enzymes Involved in the Biosynthesis of Benzylisoquinoline Alkaloids in Opium Poppy (Papaver...
Benzylisoquinoline alkaloids (BIAs) are a large group of nitrogen-containing specialized metabolites. Opium poppy (Papaver ... Characterization of Oxidative Enzymes Involved in the Biosynthesis of Benzylisoquinoline Alkaloids in Opium Poppy (Papaver ...
https://prism.ucalgary.ca/handle/11023/2115
Natural Product Biosynthesis by Microorganisms and Plants, Part A, Volume 515 - 1st EditionNatural Product Biosynthesis by Microorganisms and Plants, Part A, Volume 515 - 1st Edition
Chapter Eleven Biochemical Genomics for Gene Discovery in Benzylisoquinoline Alkaloid Biosynthesis in Opium Poppy and Related ...
https://www.elsevier.com/books/natural-product-biosynthesis-by-microorganisms-and-plants-part-a/hopwood/978-0-12-394290-6
BoraginalesBoraginales
TROCHODENDRALES [BUXALES + CORE EUDICOTS]]: benzylisoquinoline alkaloids 0; euAP3 + TM6 genes [duplication of paleoAP3 gene: B ... CHLORANTHALES + MAGNOLIIDS] [MONOCOTS [CERATOPHYLLALES + EUDICOTS]]] / MESANGIOSPERMAE: benzylisoquinoline alkaloids +; ...
http://www.mobot.org/MOBOT/Research/APweb/orders/boraginalesweb.htm
BerberidopsidalesBerberidopsidales
CHLORANTHALES + MAGNOLIIDS] [MONOCOTS [CERATOPHYLLALES + EUDICOTS]]] / MESANGIOSPERMAE: benzylisoquinoline alkaloids +; ...
http://www.mobot.org/MOBOT/research/APweb/orders/berberidopsidalesweb.html
MagnolialesMagnoliales
CHLORANTHALES + MAGNOLIIDS] [MONOCOTS [CERATOPHYLLALES + EUDICOTS]]] / MESANGIOSPERMAE: benzylisoquinoline alkaloids +; ...
http://www.mobot.org/mobot/research/APWeb/orders/magnolialesweb.htm
Tubocurarine chloride - WikipediaTubocurarine chloride - Wikipedia
Structurally, tubocurarine is a benzylisoquinoline derivative. For many years, its structure, when first elucidated in 1948, ...
https://en.wikipedia.org/wiki/Tubocurarine_chloride
Nelumbo nucifera - WikipediaNelumbo nucifera - Wikipedia
Menendez-Perdomo, I. M. and P. J. Facchini (2018). "Benzylisoquinoline Alkaloids Biosynthesis in Sacred Lotus." Molecules 23(11 ... "Anti-HIV benzylisoquinoline alkaloids and flavonoids from the leaves of Nelumbo nucifera, and structure-activity correlations ... neferine and many other benzylisoquinoline alkaloids with medicinal properties.[54][55] ... "Isolation and characterization of two O-methyltransferases involved in benzylisoquinoline alkaloid biosynthesis in sacred lotus ...
https://en.wikipedia.org/wiki/Nelumbo_nucifera
Laudanosine - WikipediaLaudanosine - Wikipedia
Burger A (2005) [1954]. "The Benzylisoquinoline Alkaloids". In Manske RH, Holmes HL (eds.). The Alkaloids: Chemistry and ...
https://en.wikipedia.org/wiki/Laudanosine
Tetrandrine: a novel calcium channel antagonist inhibits type I calcium channels in neuroblastoma cellsTetrandrine: a novel calcium channel antagonist inhibits type I calcium channels in neuroblastoma cells
Benzylisoquinolines* * Calcium Channel Blockers / pharmacology* * Flunarizine / pharmacology * Kinetics * Membrane Potentials ...
https://pubmed.ncbi.nlm.nih.gov/1787886/?dopt=Abstract
Anesthetics Flashcards by Cath Y | BrainscapeAnesthetics Flashcards by Cath Y | Brainscape
Mivacurium (Benzylisoquinolines) - competitive neuromuscular receptor blocker (AchR). - little muscarinic or ganglionic AchR ...
https://www.brainscape.com/flashcards/anesthetics-4503408/packs/6541232
MEDLINE - Resultado p gina 1 MEDLINE - Resultado p gina 1
0 (Alkaloids); 0 (Benzylisoquinolines); 0 (Glycosides); 0 (Iridoids); 0 (Monoterpenes); 0 (Tetrahydroisoquinolines); 56W89FBX3E ...
http://bases.bireme.br/cgi-bin/wxislind.exe/iah/online/?IsisScript=iah/iah.xis&nextAction=lnk&base=MEDLINE&lang=p&format=detailed.pft&indexSearch=EX&exprSearch=B01.650.940.800.575.912.250.583.640
New Developments in the Separation of Natural Products | SpringerLinkNew Developments in the Separation of Natural Products | SpringerLink
Benzylisoquinoline alkaloids from Anisocycla cymosa roots. Planta Medica 55: 394.PubMedCrossRefGoogle Scholar ...
https://link.springer.com/chapter/10.1007/978-1-4684-9060-2_1
Saira Bates | Orphan USASaira Bates | Orphan USA
A bis-benzylisoquinoline alkaloid for use with chemotherapy for refractory and relapsed acute myeloid leukemia (AML). Saira ... Saira Bates / A bis-benzylisoquinoline alkaloid for use with chemotherapy for refractory and relapsed acute myeloid leukemia ( ...
http://www.terrapinn.com/conference/world-orphan-drug-congress-usa/speaker-saira-BATES.stm
Metabolic division of labor in microbial systems | PNASMetabolic division of labor in microbial systems | PNAS
2008) Microbial production of plant benzylisoquinoline alkaloids. Proc Natl Acad Sci USA 105:7393-7398. ... 2008) Production of benzylisoquinoline alkaloids in Saccharomyces cerevisiae. Nat Chem Biol 4:564-573. ...
https://www.pnas.org/content/115/10/2526
Papaverine - DrugBankPapaverine - DrugBank
Benzylisoquinolines. Direct Parent. Benzylisoquinolines. Alternative Parents. Dimethoxybenzenes / Phenoxy compounds / Anisoles ... benzylisoquinoline alkaloid, dimethoxybenzene, isoquinolines (CHEBI:28241) / Isoquinoline alkaloids (C06533) Targets. Details1 ... Benzylisoquinoline / O-dimethoxybenzene / Dimethoxybenzene / Phenoxy compound / Anisole / Phenol ether / Methoxybenzene / Alkyl ... This compound belongs to the class of organic compounds known as benzylisoquinolines. These are organic compounds containing an ...
https://www.drugbank.ca/drugs/DB01113
Pharm Flashcards by Tina Jaramillo | BrainscapePharm Flashcards by Tina Jaramillo | Brainscape
AlkaloidsTetrandrinePapaverMetabolismMorphinePrecursorsCompoundsIsoquinolinePathwayTetrahydropapaverolineInhibitionOpiumSynthaseTubocurarineDerivativeSubstancesPrecursorChemistryMolecules
Alkaloids21
  • but most notably it is found within the structures of a wide variety of plant natural products, collectively referred to as benzylisoquinoline alkaloids. (wikipedia.org)
  • These pathways collectively lead to the structurally disparate compounds comprising the broad classification of plant natural products referred to as benzylisoquinoline alkaloids (BIA), which have been comprehensively discussed by Hagel. (wikipedia.org)
  • The 5-HT and [alpha]-adrenoceptor antagonist effect of four benzylisoquinoline alkaloids on rat aorta. (thefreedictionary.com)
  • The five major alkaloids are mainly divided into two distinct chemical classes (Reisine 1996:527)--phenanthrenes (morphine, codeine thebaine) and benzylisoquinolines (papaverine and noscapine). (thefreedictionary.com)
  • 1999) families, which produce a wide range of isoquinoline alkaloids structures as benzylisoquinolines , bisbenzylisoquinolines, aporphines, proaporphines and oxoaporphines (Mahiou et al. (thefreedictionary.com)
  • Catret M, Anselmi E, Ivorra MD (1992) Antiserotonergic effect of aporphine and benzylisoquinoline alkaloids in rat aorta. (thefreedictionary.com)
  • Opium poppy ( Papaver somniferum L . ), known for biosynthesis of several therapeutically important benzylisoquinoline alkaloids (BIAs), has emerged as the premier organism to study plant alkaloid metabolism. (springer.com)
  • This is the first committed step in the biosynthesis of the benzylisoquinoline alkaloids that include morphine and codeine. (ubc.ca)
  • Benzylisoquinoline alkaloids (BIAs) represent a diverse class of plant specialized metabolites sharing a common biosynthetic origin beginning with tyrosine. (beds.ac.uk)
  • Benzylisoquinoline alkaloids (BIAs) are a diverse class of plant specialized metabolites that includes approximately 2500 known compounds. (beds.ac.uk)
  • Benzylisoquinoline alkaloids (BIAs) are a large group of nitrogen-containing specialized metabolites. (ucalgary.ca)
  • Reconstituting plant secondarymetabolism in Saccharomyces cerevisiae for production of high-value benzylisoquinoline alkaloids. (concordia.ca)
  • 2016.Microbial factories for the production of benzylisoquinoline alkaloids. (concordia.ca)
  • Bifunctional protein involved in the biosynthesis of morphinan-type benzylisoquinoline alkaloids. (uniprot.org)
  • A database for Benzylisoquinoline Alkaloids. (mdibl.org)
  • In addition to monoterpene indole alkaloids, the benzylisoquinoline alkaloids are another class of medicinally important plant derived natural products. (mit.edu)
  • Glucose, a sugar compound, sits at the bottom, while the top level is filled with morphine, codeine and other members of a drug family known as benzylisoquinoline alkaloids (BIAs). (pbs.org)
  • Yeast cells producing the yellow beet pigment betaxanthin, which UC Berkeley researchers used to quickly identify key enzymes in the production of benzylisoquinoline alkaloids (BIAs), the metabolites in the poppy plant that could lead to morphine, antibiotics and other pharmaceutical agents. (pbs.org)
  • Biochemically, magnoliids are characterized by the presence of benzylisoquinoline or aporphine alkaloids , which are secondary metabolites with a defensive function and are rare in other groups. (britannica.com)
  • Benzylisoquinoline alkaloids (BIAs) are important secondary plant metabolites and include medicinally relevant drugs, such as morphine or codeine. (ipb-halle.de)
  • Research of this type has led him into the indole, benzylisoquinoline, and isoquinoline alkaloid areas, as well as the chemistry of the important alkaloids quinine, quinidine and reserpine. (uwm.edu)
Tetrandrine5
  • Tetrandrine is a benzylisoquinoline alkaloid that has been used in China as an antifibrotic drug to treat the lesions of silicosis. (cdc.gov)
  • Tetrandrine, a bis-benzylisoquinoline alkaloid derived from Stephania tetrandra, is a calcium channel blocker. (selleckchem.com)
  • Differential inhibition of rat alpha3* and alpha7 nicotinic acetylcholine receptors by tetrandrine and closely related bis-benzylisoquinoline derivatives. (abcam.com)
  • Anti-inflammatory and immunosuppressive properties of the bis- benzylisoquinolines: in vitro comparisons of tetrandrine and berbamine. (cat-health-guide.org)
  • Tetrandrine, a benzylisoquinoline alka- loid, which has been used as an antifibrotic drug to treat the lesions of silicosis and has been characterized as a hydroxyl radical (OH) scavenger, inhibited the NF-KB activation induced by silica, lipopolysaccharide (LPS), and phorbol 12-myristate 13-acetate (PMA). (cdc.gov)
Papaver2
  • alpha-Narcotine is an alkaloid from Papaver somniferum (opium poppy).Noscapine (also known as Narcotine, Nectodon, Nospen, and Anarcotine) is a benzylisoquinoline alkaloid from plants of the Papaveraceae family, without significant painkilling properties. (hmdb.ca)
  • Functional characterization of a novel benzylisoquinoline O-methyltransferase suggests its involvement in papaverine biosynthesis in opium poppy (Papaver somniferum L). (thefreedictionary.com)
Metabolism2
  • Hagel, J. M. & Facchini, P. J. Benzylisoquinoline alkaloid metabolism: a century of discovery and a brave new world. (nature.com)
  • Dioxygenases catalyze O-demethylation and O, O-demethylenation with widespread roles in benzylisoquinoline alkaloid metabolism in opium poppy. (genscript.com)
Morphine1
  • Stefani read the label quietly to herself, "Morphine - benzylisoquinoline. (writerscafe.org)
Precursors2
  • Among nitro-containing metabolites, the aristolochic acids are a family of substituted 10-nitro-1-phenantropic acids, biogenetically derived from benzylisoquinoline precursors, which in turn originate from tyrosine amino acid (Michl et al. (thefreedictionary.com)
  • [9] Furthermore, this association thereby suggested a biosynthetic relationship with norlaudanosoline ( tetrahydropapaveroline ) or related benzylisoquinoline precursors, which in turn are derived from tyrosine (2). (wikipedia.org)
Compounds2
  • The latter may be taspine or some of several benzylisoquinoline-like compounds. (scielo.br)
  • Studies on the Syntheses of 7, 8-Disubstituted 1-Benzylisoquinoline and Related Compounds. (nii.ac.jp)
Isoquinoline1
  • Substitution of the heterocycle isoquinoline at the C1 position by a benzyl group provides 1‑benzylisoquinoline, the most widely examined of the numerous benzylisoquinoline structural isomers. (wikipedia.org)
Pathway1
  • StWRKY8 transcription factor regulates benzylisoquinoline alkaloid pathway in potato conferring resistance to late blight. (semanticscholar.org)
Tetrahydropapaveroline1
  • Previous studies have utilized monoamine oxidase (MAO) and L-3,4-dihydroxyphenylalanine decarboxylase (DDC) for microbe-based production of tetrahydropapaveroline (THP), a benzylisoquinoline alkaloid (BIA) precursor to opioid analgesics. (vt.edu)
Inhibition2
  • Selective inhibition of calcium entry induced by benzylisoquinolines in rat smooth muscle was studied (Catret et al. (thefreedictionary.com)
  • Anselmi E, Fayos G, Blasco R, Candenas L, Cortes D, D'Ocon MP (1991) Selective inhibition of calcium entry induced by benzylisoquinolines in rat smooth muscle. (thefreedictionary.com)
Opium1
  • 180 181 a benzylisoquinoline alkaloid 180 181 a prepared synthetically or obtained from opium. (drugs.com)
Synthase1
  • In a reaction analogous to that catalyzed by strictosidine synthase, the first committed step of benzylisoquinoline biosynthesis is a Pictet-Spengler reaction between 4-hydroxyphenylactetaldehyde and dopamine, catalyzed by the enzyme norcoclaurine synthase. (mit.edu)
Tubocurarine1
  • Structurally, tubocurarine is a benzylisoquinoline derivative. (wikipedia.org)
Derivative1
Substances1
  • Arnault C (1979) Influence de substances de la plante-hote sur le developpement larvaire d 'Acrolepiopsis assectella (Lepidoptera, Acrolepiidae) en alimentation artificielle. (springer.com)
Precursor1
  • The enzymes allow the yeast to produce a chemical called reticuline, which is a precursor for many different classes of benzylisoquinoline alkaloid (BIA) molecules. (eurekalert.org)
Chemistry1
  • After his retirement from Uniroyal he continued as an Adjunct Professor of Chemistry at the University of Waterloo where the structure of the dimeric benzylisoquinoline concentrine, the most novel and complex alkaloid he had isolated at NRC, was finally settled 38 years later, in 1970. (thefreedictionary.com)
Molecules1
  • Therefore, in addition to presenting the first RNA aptamers to a subclass of benzylisoquinoline alkaloid molecules, this work highlights a method for characterizing small molecule aptamers that is more robust, precise, rapid and high-throughput than other commonly employed techniques. (nih.gov)