Inhibition of human immunodeficiency virus type 1 replication by combination of transcription inhibitor K-12 and other antiretroviral agents in acutely and chronically infected cells. (1/274)
8-Difluoromethoxy-1-ethyl-6-fluoro-1,4-dihydro-7-[4-(2-methoxyp hen yl)-1- piperazinyl]-4-oxoquinoline-3-carboxylic acid (K-12) has recently been identified as a potent and selective inhibitor of human immunodeficiency virus type 1 (HIV-1) transcription. In this study, we examined several combinations of K-12 and other antiretroviral agents for their inhibitory effects on HIV-1 replication in acutely and chronically infected cell cultures. Combinations of K-12 and a reverse transcriptase (RT) inhibitor, either zidovudine, lamivudine, or nevirapine, synergistically inhibited HIV-1 replication in acutely infected MT-4 cells. The combination of K-12 and the protease inhibitor nelfinavir (NFV) also synergistically inhibited HIV-1, whereas the synergism of this combination was weaker than that of the combinations with the RT inhibitors. K-12 did not enhance the cytotoxicities of RT and protease inhibitors. Synergism of the combinations was also observed in acutely infected peripheral blood mononuclear cells. The combination of K-12 and cepharanthine, a nuclear factor kappa B inhibitor, synergistically inhibited HIV-1 production in tumor necrosis factor alpha-stimulated U1 cells, a promonocytic cell line chronically infected with the virus. In contrast, additive inhibition was observed for the combination of K-12 and NFV. These results indicate that the combinations of K-12 and clinically available antiretroviral agents may have potential as chemotherapeutic modalities for the treatment of HIV-1 infection. (+info)Effects of dauricine, quinidine, and sotalol on action potential duration of papillary muscles in vitro. (2/274)
AIM: To compare the characteristics of dauricine, sotalol, and quinidine on action potential duration (APD). METHODS: Using intracellular microelectrode method to record APD in guinea pig papillary muscles. RESULTS: Dauricine 20 mumol.L-1 prolonged action potential at 90% repolarization, the percent of APD prolongation were 22 +/- 8, 11 +/- 6, 9 +/- 5, 7 +/- 5, 6 +/- 3, 4.3 +/- 2.8, 4.5 +/- 2.8 at the cycle lengths of 200-2000 ms, dauricine became more effective in lengthening APD at short cycle lengths. The effect of dauricine on prolonging APD exhibited normal use-dependence, whereas quinidine 1 mumol.L-1 and sotalol 10 mumol.L-1 were less effective in lengthening APD at short cycle lengths. The effect of quinidine and sotalol on APD exhibited reverse use-dependence. CONCLUSSION: The effect of dauricine on APD depends on activation frequency. (+info)Effect of tetrandrine on proto-oncogene c-fos expression in rat cerebrum. (3/274)
AIM: To detect the effect of tetrandrine (Tet) on c-fos gene expression in cerebrum induced by lindane, a neurotoxicant which activates Ca2+ channels. METHODS: Northern and dot blotting, dual wavelength thin layer chromatography scanner, were used in this study. RESULTS: Lindane 30 mg.kg-1 given by intragastric gavage (i.g.) increased the expression of c-fos gene to 146 mm2 in rat cerebrum 1 h after treatment. Tet 1, 2, and 4 mg.kg-1 given by i.g. 30 min prior to lindane reduced c-fos gene expression in a concentration-dependent manner. Expressed genes reached only 86, 40, and 39 mm2, respectively. CONCLUSION: Tet inhibited c-fos gene expression in rat cerebrum induced by Ca2+ agonist-lindane. (+info)Stimulation of pregnant rat uterine contraction by the polychlorinated biphenyl (PCB) mixture aroclor 1242 may be mediated by arachidonic acid release through activation of phospholipase A2 enzymes. (4/274)
The polychlorinated biphenyl (PCB) mixture Aroclor 1242 (A1242) increases frequency of contractions of pregnant rat uteri, suggesting a possible mechanism for decreased gestational age and increased spontaneous abortion in women and animals exposed to PCBs. In the present study, we hypothesized that A1242-induced stimulation of uterine contraction is mediated by arachidonic acid released by phospholipase A2 (PLA2) enzymes. Isometric uterine contraction was measured in longitudinal uterine strips isolated from gestation day 10 rat. Pretreatment of uterine strips with the PLA2 inhibitor (E)-6-(bromomethylene)tetrahydro-3-(1-naphthalenyl)-2H-pyran-2-one (HELSS) or manoalide, or an inhibitor of the G protein of PLA2, isotetrandrine, completely prevented the increase of contractile frequency induced by 50 microM A1242. However, the phospholipase C inhibitors 2-nitro-4-carboxyphenyl-N,N-diphenylcarbamate (NCDC) and neomycin were unable to block stimulation of uterine contraction by A1242. In accordance, A1242 (100 microM) did not release inositol phosphates from myo-[3H]inositol-labeled myometrial cells, whereas myometrial cells prelabeled with [3H]arachidonic acid released arachidonic acid in a concentration- and time-dependent manner after exposure to A1242 (10-100 microM). A1242 significantly stimulated arachidonic acid release in the absence of extracellular calcium, although the release was attenuated. Analysis of the eicosanoids released by A1242 indicated that only 0.83% of released [3H]arachidonic acid was metabolized to eicosanoids and 99.07% remained as free arachidonate. Uterine contraction increased in strips exposed to exogenous arachidonic acid (1-100 microM). This study suggests that A1242 stimulates contraction in pregnant rat uterus by a mechanism involving PLA2-mediated arachidonic acid release, and that arachidonic acid, rather than eicosanoids, may mediate A1242 uterotonic action in the uterus. (+info)Tetrandrine inhibited chronic "inflammatory" pulmonary hypertension in rats. (5/274)
AIM: To study the effects of tetrandrine (Tet), on pulmonary hypertension. METHODS: An "inflammatory" chronic pulmonary hypertension induced by monocrotaline (Mon) in rats was used. RESULTS: Tet 50, 100, and 150 mg.kg-1.d-1 i.g. 3 wk inhibited Mon-induced increase of pulmonary artery pressure (PAP) by 23.8%, 34.9% (P < 0.05), and 42.0%, (P < 0.05); the right heart index by 2.0%, 25.0%, and 30.0% (P < 0.05) respectively compared with those from Mon group, without significant influence on the systemic artery pressure (SAP). Using histological exam by Verhoeff elastic stain and computer scanning analysis, it was found that Tet (100 mg.kg-1.d-1) for 3 wk, inhibited the increase of medial thickness and cross sectional area by 57.8% (P < 0.01) and 54.6% (P < 0.01), respectively vs Mon group. CONCLUSION: Tet ameliorated the development of pulmonary vascular and lung tissue injury induced by Mon in rats. (+info)Dauricine inhibited L-type calcium current in single cardiomyocyte of guinea pig. (6/274)
AIM: To study the effect of dauricine (Dau) on L-type calcium current in guinea pig ventricular myocytes. METHODS: Using whole-cell recording method to record L-type calcium current (ICa) in single ventricular cell of guinea pig. RESULTS: Dau 1, 10, and 100 mumol.L-1 markedly reduced ICa by 15.2% +/- 2.2%, 41% +/- 5%, and 82% +/- 8%, respectively. After washing out, ICa partially recovered. Dau inhibited ICa at 3 Hz and 1 Hz to a similar extent, its effect on ICa appeared to be not frequency-dependent. CONCLUSION: Dau had a calcium channel blocking effect. (+info)Effects of anti-rheumatic herbal medicines on cellular adhesion molecules. (7/274)
OBJECTIVE: To test the hypothesis whether herbal medicines ameliorate inflammatory diseases via the modulation of cellular adhesion molecules (CAMs). METHODS: Human neutrophils, synovial fibroblasts, and endothelial cells were incubated with different concentrations of Tripterygium Wilfordii Hook-f (TWH-f) or Tetrandrine in the presence or absence of interleukin 1 (IL1). The amount of soluble E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cellular adhesion molecule-1 (VCAM-1) secreted by cells were determined by ELISA. The cell surface expression of these three CAMs was detected by flow cytometry. RESULTS: TWH-f at high concentration (50 ng/ml) has a significant (p<0.05) inhibitory effect on both the secretion and the expression of the cellular adhesion molecules. However, Tetrandrine did not demonstrate the same effects. CONCLUSIONS: The cellular adhesion molecules of the endothelium and leucocytes may constitute excellent targets for the development of new anti-inflammation medicines. These results indicate that TWH could be a potential therapeutic agent in the treatment of inflammatory diseases. (+info)Effects of N-methyl berbamine on delayed outward potassium current in isolated rat hepatocytes. (8/274)
AIM: To study the effects of N-methyl berbamine (NMB) on the delayed outward potassium currents (Ik) in isolated rat hepatocytes. METHODS: With patch-clamp techniques and whole-cell recording method, holding potential -50 mV, command potential +30 to +140 mV, duration 900 ms. RESULTS: NMB reduced Ik in a concentration-dependent manner. When the concentrations of NMB were 20, 50, 400 nmol.L-1 and 50 mumol.L-1, the amplitude values of Ik were decreased to 3.6 +/- 0.4 (P > 0.05), 2.1 +/- 1.6 (P > 0.05), 3.7 +/- 1.6 (P < 0.05), 2.3 +/- 1.3 nA (P < 0.01) from 4.4 +/- 1.0 (n = 4), 2.5 +/- 1.8 (n = 4), 5.8 +/- 2.1 (n = 5), 4.6 +/- 1.3 (n = 6) nA of control, respectively. The inhibitory rates were 10%, 15%, 37%, and 51%, respectively. CONCLUSION: NMB was a K+ channel inhibitor. (+info)
Tetrandrine - Wikipedia
BIAdb: A curated database of benzylisoquinoline alkaloids | BMC Pharmacology | Full Text
Tetrandrine: a novel calcium channel antagonist inhibits type I calcium channels in neuroblastoma cells
Studies on the calcium antagonistic action of tetrandrine: VI. Effects of tetrandrine on contractility of isolated rat uterus -...
Molecules | Free Full-Text | Identification of Three New N-Demethylated and O-Demethyled Bisbenzylisoquinoline Alkaloid...
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Laudanosine
Burger A (2005) [1954]. "The Benzylisoquinoline Alkaloids". In Manske RH, Holmes HL (eds.). The Alkaloids: Chemistry and ...
Xylopine
... is an antimicrobial benzylisoquinoline alkaloid. Villar, A; Mares, M; Rios, JL; Canton, E; Gobernado, M (1987). " ... "Antimicrobial activity of benzylisoquinoline alkaloids". Die Pharmazie. 42 (4): 248-50. PMID 3615557. v t e (Pages using ... Benzylisoquinoline alkaloids, Dibenzoquinolines, Benzodioxoles, All stub articles, Alkaloid stubs). ...
Tubocurarine chloride
Structurally, tubocurarine is a benzylisoquinoline derivative. For many years, its structure, when first elucidated in 1948, ... Benzylisoquinoline alkaloids, Cyclophanes, Macrocycles, Muscle relaxants, Neuromuscular blockers, Neurotoxins, Nicotinic ...
Nelumbo nucifera
The plant also contains nuciferine, neferine and many other benzylisoquinoline alkaloids with medicinal properties. All parts ... Menendez-Perdomo, I. M. and P. J. Facchini (2018). "Benzylisoquinoline Alkaloids Biosynthesis in Sacred Lotus." Molecules 23(11 ... "Anti-HIV benzylisoquinoline alkaloids and flavonoids from the leaves of Nelumbo nucifera, and structure-activity correlations ... "Isolation and characterization of two O-methyltransferases involved in benzylisoquinoline alkaloid biosynthesis in sacred lotus ...
Computational Resource for Drug Discovery
BIAdb: A Database for Benzylisoquinoline Alkaloids. The Benzylisoquinoline Alkaloid Database is an attempt to gather the ... A curated database of benzylisoquinoline alkaloids". BMC Pharmacology. 10: 4. doi:10.1186/1471-2210-10-4. PMC 2844369. PMID ...
Atracurium besilate
McCorkindale NJ, Magrill DS, Martin-Smith M, Smith SJ, Stenlake JB (1964). "Petaline: A 7,8-dioxygenated benzylisoquinoline". ...
Higenamine
Hagel JM, Facchini PJ (May 2013). "Benzylisoquinoline alkaloid metabolism: a century of discovery and a brave new world". Plant ... S)-Norcoclaurine/Higenamine is at the center of benzylisoquinoline alkaloid (BIA) biosynthesis. In spite of large structure ... Beaudoin GA, Facchini PJ (July 2014). "Benzylisoquinoline alkaloid biosynthesis in opium poppy". Planta. 240 (1): 19-32. doi: ... "Anti-HIV benzylisoquinoline alkaloids and flavonoids from the leaves of Nelumbo nucifera, and structure-activity correlations ...
Morphinone reductase
"Microbial production of plant benzylisoquinoline alkaloids". Proceedings of the National Academy of Sciences. 105 (21): 7393- ...
S)-norcoclaurine synthase
The first committed enzyme in benzylisoquinoline alkaloid biosynthesis in plants". J. Biol. Chem. 277 (37): 33878-83. doi: ... Stadler R, Kutchan TM, Zenk MH (1989). "(S)-Norcoclaurine is the central intermediate in benzylisoquinoline alkaloid ... This enzyme participates in benzylisoquinoline alkaloid biosynthesis. Stadler R, Zenk MH (1990). "A revision of the generally ...
Reticuline
It is based on the benzylisoquinoline structure. Reticuline is one of the alkaloids found in opium, and experiments in rodents ...
Isoquinoline alkaloids
The most common structural types are the benzylisoquinolines and the aporphines. According to current knowledge, a total of ...
Sanguinaria
Bloodroot produces benzylisoquinoline alkaloids, primarily the toxin sanguinarine. The alkaloids are transported to and stored ... also produce such benzylisoquinoline alkaloids. Plant geneticists have identified and sequenced genes which produce the enzymes ...
Noscapine
Chorismic acid is a precursor to the amino acid tyrosine, the source of nitrogen in benzylisoquinoline alkaloids. Tyrosine can ... Singh, A.; Menéndez-Perdomo, I. M.; Facchini, P. J. (2019). "Benzylisoquinoline alkaloid biosynthesis in opium poppy: an update ... Noscapine (also known as Narcotine, Nectodon, Nospen, Anarcotine and (archaic) Opiane) is a benzylisoquinoline alkaloid, of the ... These reactions produce (S)-reticuline, a key branchpoint intermediate in the biosynthesis of benzylisoquinoline alkaloids. The ...
Alfred Burger
His dissertation was entitled, "Synthesis of Benzylisoquinoline Alkaloids." He traveled to the University of Virginia as a ...
Papaver somniferum
2019). "Benzylisoquinoline alkaloid biosynthesis in opium poppy: an update." Phytochem Rev 18(6): 1457-1482 Menéndez-Perdomo I. ... which carries the benzylisoquinoline skeleton that gives its name to this pathway. The conversion of (S) -norcoclaurin to (S) - ... M., Hagel J.M. and Facchini P.J. (2021). "Benzylisoquinoline alkaloid analysis using high-resolution Orbitrap LC-MSn." J Mass ... synthesized through the metabolic pathway of benzylisoquinoline. First, the amino acid phenylalanine, through the enzyme ...
4-hydroxyphenylpyruvate decarboxylase
Rueffer M, Zenk MH (1987). "Distant precursors of benzylisoquinoline alkaloids and their enzymatic formation". Z. Naturforsch. ...
Canadine
It is also an intermediate in the complex biosynthesis of noscapine, which is likewise a benzylisoquinoline alkaloid, but of ... S)-Canadine, also known as (S)-tetrahydroberberine and xanthopuccine, is a benzylisoquinoline alkaloid (BIA), of the ... "Transcriptome analysis of 20 taxonomically related benzylisoquinoline alkaloid-producing plants". BMC Plant Biology. 15: 227. ...
Tetrandrine
... , a bis-benzylisoquinoline alkaloid, is a calcium channel blocker. It is isolated from the plant Stephania tetrandra ... Kwan, C. Y.; Achike, F. I. (2002). "Tetrandrine and related bis-benzylisoquinoline alkaloids from medicinal herbs: ... Kwan, C. Y.; Achike, F. I. (2002). "Tetrandrine and related bis-benzylisoquinoline alkaloids from medicinal herbs: ...
Scoulerine
... , also known as discretamine and aequaline, is a benzylisoquinoline alkaloid (BIA) that is derived directly from (S)- ... "Transcriptome analysis of 20 taxonomically related benzylisoquinoline alkaloid-producing plants". BMC Plant Biology. 15: 227. ...
Protopine
... is metabolically derived from the benzylisoquinoline alkaloid (S)-Reticuline through a progressive series of five ... "Transcriptome analysis of 20 taxonomically related benzylisoquinoline alkaloid-producing plants". BMC Plant Biology. 15: 227. ...
Cheilanthifoline
S)-Cheilanthifoline is a benzylisoquinoline alkaloid (BIA) which has been isolated from Corydalis dubia and Argemone mexicana.[ ... "Transcriptome analysis of 20 taxonomically related benzylisoquinoline alkaloid-producing plants". BMC Plant Biology. 15: 227. ...
BBE-like enzymes
Also, marks a branch point in the biosynthesis of benzylisoquinoline alkaloids. As mentioned above, BBE-like enzymes are in the ...
Aristolochic acid
... or related benzylisoquinoline precursors, which in turn are derived from tyrosine (2). Feeding studies (Aristolochia sipho) ... The first enzyme in the benzylisoquinoline biosynthetic pathway". FEBS Letters. 129: 5-9. doi:10.1016/0014-5793(81)80742-9. ...
Lauraceae
Benzylisoquinoline alkaloids include aporphines and oxoaporphines, as well as derivatives of morphinans. Essential oils include ...
Morphine
... is a benzylisoquinoline alkaloid with two additional ring closures. As Jack DeRuiter of the Department of Drug ...
Chelidonine
Benzylisoquinoline alkaloids (BIAs) are a structurally diverse group of plant specialized metabolites with a long history of ... Hagel, J. M, & Facchini, P. J. (2013). Benzylisoquinoline Alkaloid Metabolism: A Century of Discovery and a Brave New World. ...
Isoquinoline
1-Benzylisoquinoline is the structural backbone in naturally occurring alkaloids including papaverine. The isoquinoline ring in ...
Poppy tea
... contains two groups of alkaloids: phenanthrenes (including morphine and codeine) and benzylisoquinolines (including ...
Aminosteroid
Benzylisoquinolines, such as atracurium and tubocurarine, the other major group of neuromuscular blocking agents Ted Lin; Tim ...
Mivacurium chloride
Mivacurium belongs to a class of compounds that is commonly and erroneously referred to as "benzylisoquinolines;" mivacurium is ... Partial saturation of the benzylisoquinoline ring to the tetrahydroisoquinoline ring provided an even further increase in ... the use of a benzylisoquinoline neuromuscular blocking agent. The heritage of mivacurium and indeed its very closely related ...
Benzylisoquinoline - Wikipedia
1-Benzylisoquinolines as precursors of thebaine, codeine, and morphine". J Chem Soc: 3600. Benzylisoquinoline biosynthesis by ... the most widely examined of the numerous benzylisoquinoline structural isomers. The 1-benzylisoquinoline moiety can be ... Hagel, Jillian M; Facchini, Peter J (2013). "Benzylisoquinoline alkaloid metabolism: A century of discovery and a brave new ... Substitution of the heterocycle isoquinoline at the C1 position by a benzyl group provides 1‑benzylisoquinoline, ...
Calabdion: A new agent to revert the effects of steroid or benzylisoquinoline neuromuscular blocking agents
Stereochemical inversion of (S)-reticuline by a cytochrome P450 fusion in opium poppy | Nature Chemical Biology
Hagel, J.M. & Facchini, P.J. Benzylisoquinoline alkaloid metabolism: a century of discovery and a brave new world. Plant Cell ... Plant cytochrome P450s directing monoterpene indole alkaloid (MIA) and benzylisoquinoline alkaloid (BIA) biosynthesis *Danielle ... Desgagné-Penix, I. & Facchini, P.J. Systematic silencing of benzylisoquinoline alkaloid biosynthetic genes reveals the major ... O-demethylenation with widespread roles in benzylisoquinoline alkaloid metabolism in opium poppy. J. Biol. Chem. 288, 28997- ...
BIAdb: A Database for Benzylisoquinoline Alkaloids
Identification of bis-benzylisoquinoline alkaloids as SARS-CoV-2 entry inhibitors from a library of natural products. | Signal...
Benzylisoquinolines/chemistry; Benzylisoquinolines/pharmacology; COVID-19/drug therapy; COVID-19/metabolism; COVID-19/pathology ... Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Benzylisoquinolines ... Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Benzylisoquinolines ... Identification of bis-benzylisoquinoline alkaloids as SARS-CoV-2 entry inhibitors from a library of natural products. ...
The clinical pharmacology of new benzylisoquinoline-diester compounds, with special consideration of cisatracurium and...
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Alkaloids11
- but most notably it is found within the structures of a wide variety of plant natural products, collectively referred to as benzylisoquinoline alkaloids. (wikipedia.org)
- These pathways collectively lead to the structurally disparate compounds comprising the broad classification of plant natural products referred to as benzylisoquinoline alkaloids (BIA), which have been comprehensively discussed by Hagel. (wikipedia.org)
- Singla D, Sharma A, Kaur J, Panwar B, and Raghava GPS (2010): BIAdb: A curated database of benzylisoquinoline alkaloids. (osdd.net)
- Identification of bis-benzylisoquinoline alkaloids as SARS-CoV-2 entry inhibitors from a library of natural products. (bvsalud.org)
- P lants of the order Ranunculales, especially members of the species Papaver, accumulate a large variety of benzylisoquinoline alkaloids with about 2500 structures, but only the opium poppy (Papaver somniferum) and Papaver setigerum are able to produce the analgesic and narcotic morphine and the antitussive codeine. (opioids.com)
- They produce chemicals called benzylisoquinoline alkaloids that are related to morphine and codeine. (doesgodexist.today)
- Berberine extract- Berberine is a quaternary ammonium salt from the protoberberine group of benzylisoquinoline alkaloids found in such plants as Berberis. (healthlinemags.com)
- Berberine extract- Berberine is a quaternary ammonium salt from the protoberberine crew of benzylisoquinoline alkaloids located in such flora as Berberis. (bookkeepingjournal.com)
- Benzylisoquinoline alkaloids (BIAs) have a common biosynthetic pathway that in plants derives from L-Tyrosine and has, among others, dopamine and S-reticuline as intermediates. (mappingignorance.org)
- Berberine extract- Berberine is a quaternary ammonium salt from the protoberberine team of benzylisoquinoline alkaloids observed in such vegetation as Berberis. (whitefeatherdesign.com)
- At the time, my lab work focused on the evolution of benzylisoquinoline alkaloids and cancer drugs, but came to include a study of the coumarins and neolignans (etoposide derivatives) involving other Magnoliidae-Berberidaceae plants lacking the expected alkaloidal paths. (brianaltonenmph.com)
Alkaloid biosynthesis2
- 1. Pauli, H.H. and Kutchan, T.M. Molecular cloning and functional heterologous expression of two alleles encoding ( S )- N- methylcoclaurine 3'-hydroxylase (CYP80B1), a new methyl jasmonate-inducible cytochrome P- 450-dependent mono-oxygenase of benzylisoquinoline alkaloid biosynthesis. (qmul.ac.uk)
- Het helpt je niet first trailblazing bestseller, Conscious Loving, more than 20 bespreken of er door of benzylisoquinoline alkaloid biosynthesis as a negative incentive. (nickoz.jp)
Biosynthesis1
- One of these cDNAs, exhibiting an expression pattern very similar to previously isolated cDNAs coding for enzymes in benzylisoquinoline biosynthesis, showed the highest amino acid identity to reductases in menthol biosynthesis. (opioids.com)
Compounds2
- The clinical pharmacology of new benzylisoquinoline-diester compounds, with special consideration of cisatracurium and mivacurium]. (cornell.edu)
- By far the most studied compounds are the benzylisoquinolines, especially tetrandrine. (heilpflanzen-welt.de)
Tetrandrine2
- Tetrandrine is a benzylisoquinoline alkaloid that has been used in China as an antifibrotic drug to treat the lesions of silicosis. (cdc.gov)
- Tetrandrine (NSC-77037, Fanchinine, d-Tetrandrine), a bis-benzylisoquinoline alkaloid derived from Stephania tetrandra, is a calcium channel blocker. (selleckchem.com)
Morphine1
- Some pharmaceutical painkillers and analgesics like Noscapine, papaverine and tubocurarine or the most famous opioids codeine or morphine are Benzylisoquinoline derivatives. (mappingignorance.org)
Plants2
- A cytochrome P- 450 (heme-thiolate) protein involved in benzylisoquinoline alkaloid synthesis in higher plants. (qmul.ac.uk)
- Noscapine (also known as Narcotine, Nectodon, Nospen, Anarcotine and (archaic) Opiane) is a benzylisoquinoline alkaloid from plants of the Papaveraceae family, without painkilling properties. (termwiki.com)
Group1
- Substitution of the heterocycle isoquinoline at the C1 position by a benzyl group provides 1‑benzylisoquinoline, the most widely examined of the numerous benzylisoquinoline structural isomers. (wikipedia.org)
Similar1
- They are similar to BENZYLISOQUINOLINES . (nih.gov)