ISOQUINOLINES with a benzyl substituent.

Inhibition of human immunodeficiency virus type 1 replication by combination of transcription inhibitor K-12 and other antiretroviral agents in acutely and chronically infected cells. (1/274)

8-Difluoromethoxy-1-ethyl-6-fluoro-1,4-dihydro-7-[4-(2-methoxyp hen yl)-1- piperazinyl]-4-oxoquinoline-3-carboxylic acid (K-12) has recently been identified as a potent and selective inhibitor of human immunodeficiency virus type 1 (HIV-1) transcription. In this study, we examined several combinations of K-12 and other antiretroviral agents for their inhibitory effects on HIV-1 replication in acutely and chronically infected cell cultures. Combinations of K-12 and a reverse transcriptase (RT) inhibitor, either zidovudine, lamivudine, or nevirapine, synergistically inhibited HIV-1 replication in acutely infected MT-4 cells. The combination of K-12 and the protease inhibitor nelfinavir (NFV) also synergistically inhibited HIV-1, whereas the synergism of this combination was weaker than that of the combinations with the RT inhibitors. K-12 did not enhance the cytotoxicities of RT and protease inhibitors. Synergism of the combinations was also observed in acutely infected peripheral blood mononuclear cells. The combination of K-12 and cepharanthine, a nuclear factor kappa B inhibitor, synergistically inhibited HIV-1 production in tumor necrosis factor alpha-stimulated U1 cells, a promonocytic cell line chronically infected with the virus. In contrast, additive inhibition was observed for the combination of K-12 and NFV. These results indicate that the combinations of K-12 and clinically available antiretroviral agents may have potential as chemotherapeutic modalities for the treatment of HIV-1 infection.  (+info)

Effects of dauricine, quinidine, and sotalol on action potential duration of papillary muscles in vitro. (2/274)

AIM: To compare the characteristics of dauricine, sotalol, and quinidine on action potential duration (APD). METHODS: Using intracellular microelectrode method to record APD in guinea pig papillary muscles. RESULTS: Dauricine 20 mumol.L-1 prolonged action potential at 90% repolarization, the percent of APD prolongation were 22 +/- 8, 11 +/- 6, 9 +/- 5, 7 +/- 5, 6 +/- 3, 4.3 +/- 2.8, 4.5 +/- 2.8 at the cycle lengths of 200-2000 ms, dauricine became more effective in lengthening APD at short cycle lengths. The effect of dauricine on prolonging APD exhibited normal use-dependence, whereas quinidine 1 mumol.L-1 and sotalol 10 mumol.L-1 were less effective in lengthening APD at short cycle lengths. The effect of quinidine and sotalol on APD exhibited reverse use-dependence. CONCLUSSION: The effect of dauricine on APD depends on activation frequency.  (+info)

Effect of tetrandrine on proto-oncogene c-fos expression in rat cerebrum. (3/274)

AIM: To detect the effect of tetrandrine (Tet) on c-fos gene expression in cerebrum induced by lindane, a neurotoxicant which activates Ca2+ channels. METHODS: Northern and dot blotting, dual wavelength thin layer chromatography scanner, were used in this study. RESULTS: Lindane 30 mg.kg-1 given by intragastric gavage (i.g.) increased the expression of c-fos gene to 146 mm2 in rat cerebrum 1 h after treatment. Tet 1, 2, and 4 mg.kg-1 given by i.g. 30 min prior to lindane reduced c-fos gene expression in a concentration-dependent manner. Expressed genes reached only 86, 40, and 39 mm2, respectively. CONCLUSION: Tet inhibited c-fos gene expression in rat cerebrum induced by Ca2+ agonist-lindane.  (+info)

Stimulation of pregnant rat uterine contraction by the polychlorinated biphenyl (PCB) mixture aroclor 1242 may be mediated by arachidonic acid release through activation of phospholipase A2 enzymes. (4/274)

The polychlorinated biphenyl (PCB) mixture Aroclor 1242 (A1242) increases frequency of contractions of pregnant rat uteri, suggesting a possible mechanism for decreased gestational age and increased spontaneous abortion in women and animals exposed to PCBs. In the present study, we hypothesized that A1242-induced stimulation of uterine contraction is mediated by arachidonic acid released by phospholipase A2 (PLA2) enzymes. Isometric uterine contraction was measured in longitudinal uterine strips isolated from gestation day 10 rat. Pretreatment of uterine strips with the PLA2 inhibitor (E)-6-(bromomethylene)tetrahydro-3-(1-naphthalenyl)-2H-pyran-2-one (HELSS) or manoalide, or an inhibitor of the G protein of PLA2, isotetrandrine, completely prevented the increase of contractile frequency induced by 50 microM A1242. However, the phospholipase C inhibitors 2-nitro-4-carboxyphenyl-N,N-diphenylcarbamate (NCDC) and neomycin were unable to block stimulation of uterine contraction by A1242. In accordance, A1242 (100 microM) did not release inositol phosphates from myo-[3H]inositol-labeled myometrial cells, whereas myometrial cells prelabeled with [3H]arachidonic acid released arachidonic acid in a concentration- and time-dependent manner after exposure to A1242 (10-100 microM). A1242 significantly stimulated arachidonic acid release in the absence of extracellular calcium, although the release was attenuated. Analysis of the eicosanoids released by A1242 indicated that only 0.83% of released [3H]arachidonic acid was metabolized to eicosanoids and 99.07% remained as free arachidonate. Uterine contraction increased in strips exposed to exogenous arachidonic acid (1-100 microM). This study suggests that A1242 stimulates contraction in pregnant rat uterus by a mechanism involving PLA2-mediated arachidonic acid release, and that arachidonic acid, rather than eicosanoids, may mediate A1242 uterotonic action in the uterus.  (+info)

Tetrandrine inhibited chronic "inflammatory" pulmonary hypertension in rats. (5/274)

AIM: To study the effects of tetrandrine (Tet), on pulmonary hypertension. METHODS: An "inflammatory" chronic pulmonary hypertension induced by monocrotaline (Mon) in rats was used. RESULTS: Tet 50, 100, and 150 mg.kg-1.d-1 i.g. 3 wk inhibited Mon-induced increase of pulmonary artery pressure (PAP) by 23.8%, 34.9% (P < 0.05), and 42.0%, (P < 0.05); the right heart index by 2.0%, 25.0%, and 30.0% (P < 0.05) respectively compared with those from Mon group, without significant influence on the systemic artery pressure (SAP). Using histological exam by Verhoeff elastic stain and computer scanning analysis, it was found that Tet (100 mg.kg-1.d-1) for 3 wk, inhibited the increase of medial thickness and cross sectional area by 57.8% (P < 0.01) and 54.6% (P < 0.01), respectively vs Mon group. CONCLUSION: Tet ameliorated the development of pulmonary vascular and lung tissue injury induced by Mon in rats.  (+info)

Dauricine inhibited L-type calcium current in single cardiomyocyte of guinea pig. (6/274)

AIM: To study the effect of dauricine (Dau) on L-type calcium current in guinea pig ventricular myocytes. METHODS: Using whole-cell recording method to record L-type calcium current (ICa) in single ventricular cell of guinea pig. RESULTS: Dau 1, 10, and 100 mumol.L-1 markedly reduced ICa by 15.2% +/- 2.2%, 41% +/- 5%, and 82% +/- 8%, respectively. After washing out, ICa partially recovered. Dau inhibited ICa at 3 Hz and 1 Hz to a similar extent, its effect on ICa appeared to be not frequency-dependent. CONCLUSION: Dau had a calcium channel blocking effect.  (+info)

Effects of anti-rheumatic herbal medicines on cellular adhesion molecules. (7/274)

OBJECTIVE: To test the hypothesis whether herbal medicines ameliorate inflammatory diseases via the modulation of cellular adhesion molecules (CAMs). METHODS: Human neutrophils, synovial fibroblasts, and endothelial cells were incubated with different concentrations of Tripterygium Wilfordii Hook-f (TWH-f) or Tetrandrine in the presence or absence of interleukin 1 (IL1). The amount of soluble E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cellular adhesion molecule-1 (VCAM-1) secreted by cells were determined by ELISA. The cell surface expression of these three CAMs was detected by flow cytometry. RESULTS: TWH-f at high concentration (50 ng/ml) has a significant (p<0.05) inhibitory effect on both the secretion and the expression of the cellular adhesion molecules. However, Tetrandrine did not demonstrate the same effects. CONCLUSIONS: The cellular adhesion molecules of the endothelium and leucocytes may constitute excellent targets for the development of new anti-inflammation medicines. These results indicate that TWH could be a potential therapeutic agent in the treatment of inflammatory diseases.  (+info)

Effects of N-methyl berbamine on delayed outward potassium current in isolated rat hepatocytes. (8/274)

AIM: To study the effects of N-methyl berbamine (NMB) on the delayed outward potassium currents (Ik) in isolated rat hepatocytes. METHODS: With patch-clamp techniques and whole-cell recording method, holding potential -50 mV, command potential +30 to +140 mV, duration 900 ms. RESULTS: NMB reduced Ik in a concentration-dependent manner. When the concentrations of NMB were 20, 50, 400 nmol.L-1 and 50 mumol.L-1, the amplitude values of Ik were decreased to 3.6 +/- 0.4 (P > 0.05), 2.1 +/- 1.6 (P > 0.05), 3.7 +/- 1.6 (P < 0.05), 2.3 +/- 1.3 nA (P < 0.01) from 4.4 +/- 1.0 (n = 4), 2.5 +/- 1.8 (n = 4), 5.8 +/- 2.1 (n = 5), 4.6 +/- 1.3 (n = 6) nA of control, respectively. The inhibitory rates were 10%, 15%, 37%, and 51%, respectively. CONCLUSION: NMB was a K+ channel inhibitor.  (+info)

Benzylisoquinolines are a type of naturally occurring organic compounds found in various plants. These compounds are derived from the combination of a benzyl group and an isoquinoline ring, hence the name "benzylisoquinolines." They are known to have diverse biological activities, including anti-inflammatory, antispasmodic, and antimicrobial properties. Some well-known examples of benzylisoquinoline alkaloids include papaverine, found in the opium poppy, and berberine, found in various medicinal plants such as goldenseal and barberry. These compounds have been used in traditional medicine for centuries and continue to be studied for their potential therapeutic uses.

1-Benzylisoquinolines as precursors of thebaine, codeine, and morphine". J Chem Soc: 3600. Benzylisoquinoline biosynthesis by ... the most widely examined of the numerous benzylisoquinoline structural isomers. The 1-benzylisoquinoline moiety can be ... Hagel, Jillian M; Facchini, Peter J (2013). "Benzylisoquinoline alkaloid metabolism: A century of discovery and a brave new ... Substitution of the heterocycle isoquinoline at the C1 position by a benzyl group provides 1‑benzylisoquinoline, ...
The biosynthesis of benzylisoquinoline alkaloids has been intensively studied. It begins with the amino acid tyrosine, which is ... The benzylisoquinoline alkaloids are natural products that can be classified as isoquinoline alkaloidss and are derived from ... 8 (Benzylisoquinoline alkaloids, p. 8, at Google Books). Jennifer M. Finefield, David H. Sherman, Martin Kreitman, Robert M. ... The benzylisoquinoline from this reaction may have different substituents, reticulin is an important intermediate. Entry on ...
Burger A (2005) [1954]. "The Benzylisoquinoline Alkaloids". In Manske RH, Holmes HL (eds.). The Alkaloids: Chemistry and ...
... is an antimicrobial benzylisoquinoline alkaloid. Villar, A; Mares, M; Rios, JL; Canton, E; Gobernado, M (1987). " ... "Antimicrobial activity of benzylisoquinoline alkaloids". Die Pharmazie. 42 (4): 248-50. PMID 3615557. v t e (Articles ...
Tubocurarine (also known as d-tubocurarine or DTC) is a toxic benzylisoquinoline alkaloid historically known for its use as an ... Structurally, tubocurarine is a benzylisoquinoline derivative. Its structure, when first elucidated in 1948 and for many years ... Benzylisoquinoline alkaloids, Cyclophanes, Macrocycles, Muscle relaxants, Neuromuscular blockers, Neurotoxins, Nicotinic ...
The plant also contains nuciferine, neferine, and many other benzylisoquinoline alkaloids with medicinal properties. All parts ... Menendez-Perdomo, I. M. and P. J. Facchini (2018). "Benzylisoquinoline Alkaloids Biosynthesis in Sacred Lotus." Molecules 23(11 ... "Anti-HIV benzylisoquinoline alkaloids and flavonoids from the leaves of Nelumbo nucifera, and structure-activity correlations ... "Isolation and characterization of two O-methyltransferases involved in benzylisoquinoline alkaloid biosynthesis in sacred lotus ...
BIAdb: A Database for Benzylisoquinoline Alkaloids. The Benzylisoquinoline Alkaloid Database is an attempt to gather the ... Singla D, Sharma A, Kaur J, Panwar B, Raghava GP (March 2010). "BIAdb: a curated database of benzylisoquinoline alkaloids". BMC ...
McCorkindale NJ, Magrill DS, Martin-Smith M, Smith SJ, Stenlake JB (1964). "Petaline: A 7,8-dioxygenated benzylisoquinoline". ...
Hagel JM, Facchini PJ (May 2013). "Benzylisoquinoline alkaloid metabolism: a century of discovery and a brave new world". Plant ... S)-Norcoclaurine/Higenamine is at the center of benzylisoquinoline alkaloid (BIA) biosynthesis. In spite of large structure ... Beaudoin GA, Facchini PJ (July 2014). "Benzylisoquinoline alkaloid biosynthesis in opium poppy". Planta. 240 (1): 19-32. doi: ... "Anti-HIV benzylisoquinoline alkaloids and flavonoids from the leaves of Nelumbo nucifera, and structure-activity correlations ...
"Microbial production of plant benzylisoquinoline alkaloids". Proceedings of the National Academy of Sciences. 105 (21): 7393- ...
The first committed enzyme in benzylisoquinoline alkaloid biosynthesis in plants". J. Biol. Chem. 277 (37): 33878-83. doi: ... Stadler R, Kutchan TM, Zenk MH (1989). "(S)-Norcoclaurine is the central intermediate in benzylisoquinoline alkaloid ... This enzyme participates in benzylisoquinoline alkaloid biosynthesis. Stadler R, Zenk MH (1990). "A revision of the generally ...
It is based on the benzylisoquinoline structure. Reticuline is one of the alkaloids found in opium, and experiments in rodents ...
The most common structural types are the benzylisoquinolines and the aporphines. According to current knowledge, a total of ...
Bloodroot produces benzylisoquinoline alkaloids, primarily the toxin sanguinarine. The alkaloids are transported to and stored ... also produce such benzylisoquinoline alkaloids. Plant geneticists have identified and sequenced genes which produce the enzymes ...
Chorismic acid is a precursor to the amino acid tyrosine, the source of nitrogen in benzylisoquinoline alkaloids. Tyrosine can ... Noscapine (also known as Narcotine, Nectodon, Nospen, Anarcotine and (archaic) Opiane) is a benzylisoquinoline alkaloid, of the ... These reactions produce (S)-reticuline, a key branchpoint intermediate in the biosynthesis of benzylisoquinoline alkaloids. The ... Singh A, Menéndez-Perdomo IM, Facchini PJ (2019). "Benzylisoquinoline alkaloid biosynthesis in opium poppy: an update". ...
His dissertation was entitled, "Synthesis of Benzylisoquinoline Alkaloids." He traveled to the University of Virginia as a ...
2019). "Benzylisoquinoline alkaloid biosynthesis in opium poppy: an update." Phytochem Rev 18(6): 1457-1482 Menéndez-Perdomo I. ... which carries the benzylisoquinoline skeleton that gives its name to this pathway. The conversion of (S) -norcoclaurin to (S) - ... M., Hagel J.M. and Facchini P.J. (2021). "Benzylisoquinoline alkaloid analysis using high-resolution Orbitrap LC-MSn." J Mass ... synthesized through the metabolic pathway of benzylisoquinoline. First, the amino acid phenylalanine, through the enzyme ...
Rueffer M, Zenk MH (1987). "Distant precursors of benzylisoquinoline alkaloids and their enzymatic formation". Z. Naturforsch. ...
It is also an intermediate in the complex biosynthesis of noscapine, which is likewise a benzylisoquinoline alkaloid, but of ... S)-Canadine, also known as (S)-tetrahydroberberine and xanthopuccine, is a benzylisoquinoline alkaloid (BIA), of the ... "Transcriptome analysis of 20 taxonomically related benzylisoquinoline alkaloid-producing plants". BMC Plant Biology. 15: 227. ...
... , a bis-benzylisoquinoline alkaloid, is a calcium channel blocker. It is isolated from the plant Stephania tetrandra ... Kwan, C. Y.; Achike, F. I. (2002). "Tetrandrine and related bis-benzylisoquinoline alkaloids from medicinal herbs: ... Kwan, C. Y.; Achike, F. I. (2002). "Tetrandrine and related bis-benzylisoquinoline alkaloids from medicinal herbs: ...
... , also known as discretamine and aequaline, is a benzylisoquinoline alkaloid (BIA) that is derived directly from (S)- ... "Transcriptome analysis of 20 taxonomically related benzylisoquinoline alkaloid-producing plants". BMC Plant Biology. 15: 227. ...
... is metabolically derived from the benzylisoquinoline alkaloid (S)-Reticuline through a progressive series of five ... "Transcriptome analysis of 20 taxonomically related benzylisoquinoline alkaloid-producing plants". BMC Plant Biology. 15: 227. ...
S)-Cheilanthifoline is a benzylisoquinoline alkaloid (BIA) which has been isolated from Corydalis dubia and Argemone mexicana.[ ... "Transcriptome analysis of 20 taxonomically related benzylisoquinoline alkaloid-producing plants". BMC Plant Biology. 15: 227. ...
Also, marks a branch point in the biosynthesis of benzylisoquinoline alkaloids. As mentioned above, BBE-like enzymes are in the ...
... or related benzylisoquinoline precursors, which in turn are derived from tyrosine (2). Feeding studies (Aristolochia sipho) ... The first enzyme in the benzylisoquinoline biosynthetic pathway". FEBS Letters. 129: 5-9. doi:10.1016/0014-5793(81)80742-9. ...
Benzylisoquinoline alkaloids include aporphines and oxoaporphines, as well as derivatives of morphinans. Essential oils include ...
... is a benzylisoquinoline alkaloid with two additional ring closures. As Jack DeRuiter of the Department of Drug ...
Benzylisoquinoline alkaloids (BIAs) are a structurally diverse group of plant specialized metabolites with a long history of ... Hagel, J. M, & Facchini, P. J. (2013). Benzylisoquinoline Alkaloid Metabolism: A Century of Discovery and a Brave New World. ...
1-Benzylisoquinoline is the structural backbone in naturally occurring alkaloids including papaverine. The isoquinoline ring in ...
... contains two groups of alkaloids: phenanthrenes (including morphine and codeine) and benzylisoquinolines (including ...
1-Benzylisoquinolines as precursors of thebaine, codeine, and morphine". J Chem Soc: 3600. Benzylisoquinoline biosynthesis by ... the most widely examined of the numerous benzylisoquinoline structural isomers. The 1-benzylisoquinoline moiety can be ... Hagel, Jillian M; Facchini, Peter J (2013). "Benzylisoquinoline alkaloid metabolism: A century of discovery and a brave new ... Substitution of the heterocycle isoquinoline at the C1 position by a benzyl group provides 1‑benzylisoquinoline, ...
Benzylisoquinolines [D03.438.531.085]. *Aporphines [D03.438.531.085.030]. *Heterocyclic Compounds with 4 or More Rings [D03.549 ...
Reconstituting plant secondarymetabolism in Saccharomyces cerevisiaefor production of high-value benzylisoquinoline alkaloids. ... Reconstitution of a 10-gene pathway forsynthesis of the plant benzylisoquinoline alkaloid dihydrosanguinarine in ... 2016.Microbial factories for the production of benzylisoquinoline alkaloids. Trendsin Biotechnology. 34:228-241 ...
Papaverine is a benzylisoquinoline derivative with a direct nonspecific relaxant effect on vascular, cardiac, and other smooth ...
Isoquinoline alkaloids 1-Benzyl isoquinoline type: Papaverine: An opiate alkaloid isolated from the plant Papaver somniferum ... Isoquinoline or Benzyl Isoquinoline Alkaloids - * * Biosynthesis of Indole Alkaloids Indole indole ... Indole alkaloid Indole ... Isoquinoline alkaloids - Isoquinoline alkaloids 1-Benzyl isoquinoline type: Papaverine: An opiate alkaloid isolated from the ...
... while the benzylisoquinoline alkaloids berbamine and oxyacanthine were more potent inhibitors by a factor of three. ...
The Stereochemistry at C-13 for the Proaporphine-benzylisoquinoline Alkaloids. Inge Weiss,* Alan J. Freyer, Maurice Shamma, and ... Berberidaceae) has yielded the new proaporphine-benzylisoquinolines (+)-epiberbivaldine (13) and (+)-rupancamine (15). The ...
The biogenesis of the 2-benzylisoquinoline alkaloids is also discussed. PDF (65KB) ...
keywords = "Benzylisoquinoline, Expressed sequence tag, Macroarray, Morphine, Opium poppy",. author = "J. Ziegler and Kutchan ... Papaver species are known to produce a large variety of benzylisoquinoline alkaloids, with each species exhibiting a specific ... N2 - Papaver species are known to produce a large variety of benzylisoquinoline alkaloids, with each species exhibiting a ... AB - Papaver species are known to produce a large variety of benzylisoquinoline alkaloids, with each species exhibiting a ...
They are similar to BENZYLISOQUINOLINES. Members include chelerythrine and sanguinarine.. Allowable Qualifiers:. AD ...
S)-Codamine belongs to the class of organic compounds known as benzylisoquinolines. These are organic compounds containing an ... Belongs to the class of organic compounds known as benzylisoquinolines. These are organic compounds containing an isoquinoline ...
When I talk about secondary metabolic compounds Im referring in particular to a benzylisoquinoline alkaloid called ...
... plant genes into microorganisms to reconstruct the pathways that produce a class of compounds called benzylisoquinoline ...
Aporphinoid alkaloids contain a tetracyclic ring system formed by phenol oxidative coupling of a benzylisoquinoline precursor. ... Aporphinoid alkaloids also include miscellaneous derivatives of benzylisoquinoline, such as rufescine. ...
Benzylisoquinoline alkaloid Cyc) and CannaCyc (Cannabaceae Cyc) projects and included a pathway update party where experts in ...
Anti-HIV benzylisoquinoline alkaloids and flavonoids from the leaves of Nelumbo nucifera, and structure-activity correlations ...
Gindarin is a derivative of tetrahydroprotoberberine, rotundine is a derivative of benzylisoquinoline, cicleanine is a ...
COMMENT: SubCategory_DNP: Isoquinoline alkaloids, Benzylisoquinoline alkaloids. CH$NAME: Bicuculline. CH$COMPOUND_CLASS: ...
Among them benzylisoquinoline alkaloids form an important group with potent pharmacological activity; including analgesic ... an important precursor of various benzylisoquinoline alkaloids. Pathway Name: Tropane, piperidine and pyridine alkaloid ...
Genome-wide analysis of bHLH gene family in Coptis chinensis provides insights into the regulatory role in benzylisoquinoline ... Its principal active ingredients are benzylisoquinoline alkaloids (BIAs). The basic helix-loop-helix (bHLH) transcription ...
Mechanistic Studies on Norcoclaurine Synthase of Benzylisoquinoline Alkaloid Biosynthesis: An Enzymatic Pictet−Spengler ...
Total Syntheses of Benzylisoquinoline Alkaloids Neolitacumoine, Mollinedine and Papaverine Sun Mianmian, Li Fenglei, He Yungang ...
Cytotoxic Benzophenanthridine and Benzylisoquinoline Alka-loids from Argemone mexicana. Z Naturforsch C J Biosci. 2003;58(7-8): ...
Answer- (d) 6,7-dimethoxy-1-(3, 4′-dimethoxy benzyl) isoquinoline. 26. In the steroid nucleus, there are. *(a) Six chiral ...
Hawkins, K.M.; Smolke, C.D. Production of benzylisoquinoline alkaloids in Saccharomyces cerevisiae. Nat. Chem. Biol. 2008, 4, ... The first committed enzyme in benzylisoquinoline alkaloid biosynthesis in plants. J. Biol. Chem. 2002, 277, 33878-33883. [ ... Identification and characterization of genes involved in benzylisoquinoline alkaloid biosynthesis in Coptis species. Front. ... to generate the basic 1-benzylisoquinoline core (S)-norcoclaurine [131,132,133]. (S)-Norcoclaurine continues to be methylated ...
ii) Benzyl isoquinoline group alkaloids: These include Papavarine, Noscapine, and Narceine. All three do not possess analgesic ...
Members contain uvarigrin, uvarigrandin, chamuvaritin and other acetogenins and benzylisoquinoline alkaloids. AN = coord with ...
  • but most notably it is found within the structures of a wide variety of plant natural products, collectively referred to as benzylisoquinoline alkaloids. (wikipedia.org)
  • These pathways collectively lead to the structurally disparate compounds comprising the broad classification of plant natural products referred to as benzylisoquinoline alkaloids (BIA), which have been comprehensively discussed by Hagel. (wikipedia.org)
  • Reconstituting plant secondarymetabolism in Saccharomyces cerevisiae for production of high-value benzylisoquinoline alkaloids. (concordia.ca)
  • 2016.Microbial factories for the production of benzylisoquinoline alkaloids. (concordia.ca)
  • Of its main alkaloids tested, berberine inhibited cell growth to the same extent as did the Mahonia extract, while the benzylisoquinoline alkaloids berbamine and oxyacanthine were more potent inhibitors by a factor of three. (google.com)
  • Papaver species are known to produce a large variety of benzylisoquinoline alkaloids, with each species exhibiting a specific alkaloid profile, but only a few genes involved in the biosynthesis or regulation of these complex pathways are known so far. (wustl.edu)
  • For several years a number of research teams have been inserting plant genes into microorganisms to reconstruct the pathways that produce a class of compounds called benzylisoquinoline alkaloids (BIA) , a family of around 2500 compounds, many of which have pharmacological activity - including codeine and morphine. (chemistryworld.com)
  • Chorismic acid is a precursor to the amino acid tyrosine , the source of nitrogen in benzylisoquinoline alkaloids. (cloudfront.net)
  • These reactions produce ( S )- reticuline , a key branchpoint intermediate in the biosynthesis of benzylisoquinoline alkaloids. (cloudfront.net)
  • Introduction: Genus Phoebe have been reported to produce isoquinoline alkaloids as apor-phines, noraporphines, and benzylisoquinolines. (ui.ac.id)
  • Kalra, A. Endophytes of opium poppy differentially modulate host plant productivity and genes for the biosynthetic pathway of benzylisoquinoline alkaloids. (thelondonbridged.com)
  • Some benzylisoquinoline alkaloids and flavonoids were isolated from the leaves of Nelumbo nucifera (Lotus), and identified as anti-HIV principles. (meandqi.com)
  • Anti-HIV benzylisoquinoline alkaloids and flavonoids from the leaves of Nelumbo nucifera, and structure-activity correlations with related alkaloids" Bioorganic & Medicinal Chemistry. (meandqi.com)
  • The study notes that some of the hallucinogenic alkaloid-containing plants are native to Menorca, "The flora native to Menorca includes the psychoactive species Datura stramonium, Hyoscyamus albus and Mandragora automnalis which contain the tropane derivatives atropine and scopolamine, Ephedra fragilis which contains the phenylethylamine derivative ephedrine, and Papaver somniferum which contains a variety of benzylisoquinoline alkaloids, morphine and papaverine among them. (leafie.co.uk)
  • Noscapine (also known as Narcotine , Nectodon , Nospen , Anarcotine and (archaic) Opiane ) is a benzylisoquinoline alkaloid , of the phthalideisoquinoline structural subgroup, which has been isolated from numerous species of the family Papaveraceae (poppy family). (cloudfront.net)
  • Substitution of the heterocycle isoquinoline at the C1 position by a benzyl group provides 1‑benzylisoquinoline, the most widely examined of the numerous benzylisoquinoline structural isomers. (wikipedia.org)
  • S)-Codamine belongs to the class of organic compounds known as benzylisoquinolines. (foodb.ca)
  • 1997. [The clinical pharmacology of new benzylisoquinoline-diester compounds, with special consideration of cisatracurium and mivacurium]. . (cornell.edu)
  • Dibenzoquinolines derived in plants from (S)-reticuline (BENZYLISOQUINOLINES). (harvard.edu)
  • Developmental regulation of benzylisoquinoline alkaloid biosynthesis in opium poppy plants and tissue cultures. (notulaebiologicae.ro)
  • The induction of sanguinarine biosynthesis provides a model platform to characterize the regulation of benzylisoquinoline alkaloid pathways and other defense responses. (ucalgary.ca)
  • Substitution of the heterocycle isoquinoline at the C1 position by a benzyl group provides 1‑benzylisoquinoline, the most widely examined of the numerous benzylisoquinoline structural isomers. (wikipedia.org)