Benzylisoquinolines: ISOQUINOLINES with a benzyl substituent.3,4-Dihydroxyphenylacetic Acid: A deaminated metabolite of LEVODOPA.Tetrahydropapaveroline: A leukomaine (animal alkaloid) formed in brain and liver from dopamine and L-dopa; it may be implicated in psychiatric problems.Dopa Decarboxylase: One of the AROMATIC-L-AMINO-ACID DECARBOXYLASES, this enzyme is responsible for the conversion of DOPA to DOPAMINE. It is of clinical importance in the treatment of Parkinson's disease.Coptis: A plant genus of the family RANUNCULACEAE. Members contain BERBERINE and other isoquinoline ALKALOIDS.Papaver: A genus of Eurasian herbaceous plants, the poppies (family PAPAVERACEAE of the dicotyledon class Magnoliopsida), that yield OPIUM from the latex of the unripe seed pods.Thalictrum: A plant genus of the family RANUNCULACEAE. Members contain isoquinoline alkaloids and triterpene glycosides.Opium: The air-dried exudate from the unripe seed capsule of the opium poppy, Papaver somniferum, or its variant, P. album. It contains a number of alkaloids, but only a few - MORPHINE; CODEINE; and PAPAVERINE - have clinical significance. Opium has been used as an analgesic, antitussive, antidiarrheal, and antispasmodic.Noscapine: A naturally occurring opium alkaloid that is a centrally acting antitussive agent.Berberine Alkaloids: A group of related plant alkaloids that contain the BERBERINE heterocyclic ring structure.Tubocurarine: A neuromuscular blocker and active ingredient in CURARE; plant based alkaloid of Menispermaceae.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)p-Hydroxyamphetamine: Amphetamine metabolite with sympathomimetic effects. It is sometimes called alpha-methyltyramine, which may also refer to the meta isomer, gepefrine.Curare: Plant extracts from several species, including genera STRYCHNOS and Chondodendron, which contain TETRAHYDROISOQUINOLINES that produce PARALYSIS of skeletal muscle. These extracts are toxic and must be used with the administration of artificial respiration.South AmericaAmerican Native Continental Ancestry Group: Individuals whose ancestral origins are in the continents of the Americas.Atracurium: A non-depolarizing neuromuscular blocking agent with short duration of action. Its lack of significant cardiovascular effects and its lack of dependence on good kidney function for elimination provide clinical advantage over alternate non-depolarizing neuromuscular blocking agents.Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.Muscle Relaxants, Central: A heterogeneous group of drugs used to produce muscle relaxation, excepting the neuromuscular blocking agents. They have their primary clinical and therapeutic uses in the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. They have been used also for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in MULTIPLE SCLEROSIS. (From Smith and Reynard, Textbook of Pharmacology, 1991, p358)Calcium Channels: Voltage-dependent cell membrane glycoproteins selectively permeable to calcium ions. They are categorized as L-, T-, N-, P-, Q-, and R-types based on the activation and inactivation kinetics, ion specificity, and sensitivity to drugs and toxins. The L- and T-types are present throughout the cardiovascular and central nervous systems and the N-, P-, Q-, & R-types are located in neuronal tissue.Calcium Channel Blockers: A class of drugs that act by selective inhibition of calcium influx through cellular membranes.Alkaloids: Organic nitrogenous bases. Many alkaloids of medical importance occur in the animal and vegetable kingdoms, and some have been synthesized. (Grant & Hackh's Chemical Dictionary, 5th ed)Tetrahydroisoquinolines: A group of ISOQUINOLINES in which the nitrogen containing ring is protonated. They derive from the non-enzymatic Pictet-Spengler condensation of CATECHOLAMINES with ALDEHYDES.Nandiniidae: A family in the suborder Feliformia, order CARNIVORA, comprising one genus Nandinia binotata.Adrenergic beta-1 Receptor Antagonists: Drugs that bind to and block the activation of ADRENERGIC BETA-1 RECEPTORS.Aconitine: A C19 norditerpenoid alkaloid (DITERPENES) from the root of ACONITUM plants. It activates VOLTAGE-GATED SODIUM CHANNELS. It has been used to induce ARRHYTHMIAS in experimental animals and it has antiinflammatory and antineuralgic properties.Chromatography, High Pressure Liquid: Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.Croton: A plant genus of the family EUPHORBIACEAE. The common name of dragon's blood is also used for DRACAENA and Daemonorops (ARECACEAE). Croton tiglium is the source of CROTON OIL.Croton Oil: Viscous, nauseating oil obtained from the shrub Croton tiglium (Euphorbaceae). It is a vesicant and skin irritant used as pharmacologic standard for skin inflammation and allergy and causes skin cancer. It was formerly used as an emetic and cathartic with frequent mortality.Euphorbiaceae: The spurge family of flowering plants, in the order Euphorbiales, contains some 7,500 species in 275 genera. The family consists of annual and perennial herbs and woody shrubs or trees.Diterpenes, Clerodane: A group of DITERPENES cyclized into 2-rings with a side-chain.Diterpenes, Kaurane: A group of DITERPENES cyclized into four rings.Plant Extracts: Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.Diterpenes: Twenty-carbon compounds derived from MEVALONIC ACID or deoxyxylulose phosphate.Synthetic Biology: A field of biological research combining engineering in the formulation, design, and building (synthesis) of novel biological structures, functions, and systems.Encephalitis, St. Louis: A viral encephalitis caused by the St. Louis encephalitis virus (ENCEPHALITIS VIRUS, ST. LOUIS), a FLAVIVIRUS. It is transmitted to humans and other vertebrates primarily by mosquitoes of the genus CULEX. The primary animal vectors are wild birds and the disorder is endemic to the midwestern and southeastern United States. Infections may be limited to an influenza-like illness or present as an ASEPTIC MENINGITIS or ENCEPHALITIS. Clinical manifestations of the encephalitic presentation may include SEIZURES, lethargy, MYOCLONUS, focal neurologic signs, COMA, and DEATH. (From Adams et al., Principles of Neurology, 6th ed, p750)WalesEncephalitis Virus, St. Louis: A species of FLAVIVIRUS, one of the Japanese encephalitis virus group (ENCEPHALITIS VIRUSES, JAPANESE), which is the etiologic agent of ST. LOUIS ENCEPHALITIS in the United States, the Caribbean, and Central and South America.Peer Review, Research: The evaluation by experts of the quality and pertinence of research or research proposals of other experts in the same field. Peer review is used by editors in deciding which submissions warrant publication, by granting agencies to determine which proposals should be funded, and by academic institutions in tenure decisions.Biology: One of the BIOLOGICAL SCIENCE DISCIPLINES concerned with the origin, structure, development, growth, function, genetics, and reproduction of animals, plants, and microorganisms.Molecular Biology: A discipline concerned with studying biological phenomena in terms of the chemical and physical interactions of molecules.Published ErratumMovement: The act, process, or result of passing from one place or position to another. It differs from LOCOMOTION in that locomotion is restricted to the passing of the whole body from one place to another, while movement encompasses both locomotion but also a change of the position of the whole body or any of its parts. Movement may be used with reference to humans, vertebrate and invertebrate animals, and microorganisms. Differentiate also from MOTOR ACTIVITY, movement associated with behavior.Psychomotor Performance: The coordination of a sensory or ideational (cognitive) process and a motor activity.Retraction of Publication as Topic: Authors' withdrawal or disavowal of their participation in performing research or writing the results of their study.Copying Processes: Reproduction of data in a new location or other destination, leaving the source data unchanged, although the physical form of the result may differ from that of the source.Terminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Asterina: A genus of STARFISH in the family Asterinidae. They externally hold developing embryos (EMBRYO, NON-MAMMALIAN) among the spines below the oral surface.Immunoassay: A technique using antibodies for identifying or quantifying a substance. Usually the substance being studied serves as antigen both in antibody production and in measurement of antibody by the test substance.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Foramen Ovale, Patent: A condition in which the FORAMEN OVALE in the ATRIAL SEPTUM fails to close shortly after birth. This results in abnormal communications between the two upper chambers of the heart. An isolated patent ovale foramen without other structural heart defects is usually of no hemodynamic significance.Fluorescence: The property of emitting radiation while being irradiated. The radiation emitted is usually of longer wavelength than that incident or absorbed, e.g., a substance can be irradiated with invisible radiation and emit visible light. X-ray fluorescence is used in diagnosis.Spectrometry, Fluorescence: Measurement of the intensity and quality of fluorescence.

Inhibition of human immunodeficiency virus type 1 replication by combination of transcription inhibitor K-12 and other antiretroviral agents in acutely and chronically infected cells. (1/274)

8-Difluoromethoxy-1-ethyl-6-fluoro-1,4-dihydro-7-[4-(2-methoxyp hen yl)-1- piperazinyl]-4-oxoquinoline-3-carboxylic acid (K-12) has recently been identified as a potent and selective inhibitor of human immunodeficiency virus type 1 (HIV-1) transcription. In this study, we examined several combinations of K-12 and other antiretroviral agents for their inhibitory effects on HIV-1 replication in acutely and chronically infected cell cultures. Combinations of K-12 and a reverse transcriptase (RT) inhibitor, either zidovudine, lamivudine, or nevirapine, synergistically inhibited HIV-1 replication in acutely infected MT-4 cells. The combination of K-12 and the protease inhibitor nelfinavir (NFV) also synergistically inhibited HIV-1, whereas the synergism of this combination was weaker than that of the combinations with the RT inhibitors. K-12 did not enhance the cytotoxicities of RT and protease inhibitors. Synergism of the combinations was also observed in acutely infected peripheral blood mononuclear cells. The combination of K-12 and cepharanthine, a nuclear factor kappa B inhibitor, synergistically inhibited HIV-1 production in tumor necrosis factor alpha-stimulated U1 cells, a promonocytic cell line chronically infected with the virus. In contrast, additive inhibition was observed for the combination of K-12 and NFV. These results indicate that the combinations of K-12 and clinically available antiretroviral agents may have potential as chemotherapeutic modalities for the treatment of HIV-1 infection.  (+info)

Effects of dauricine, quinidine, and sotalol on action potential duration of papillary muscles in vitro. (2/274)

AIM: To compare the characteristics of dauricine, sotalol, and quinidine on action potential duration (APD). METHODS: Using intracellular microelectrode method to record APD in guinea pig papillary muscles. RESULTS: Dauricine 20 mumol.L-1 prolonged action potential at 90% repolarization, the percent of APD prolongation were 22 +/- 8, 11 +/- 6, 9 +/- 5, 7 +/- 5, 6 +/- 3, 4.3 +/- 2.8, 4.5 +/- 2.8 at the cycle lengths of 200-2000 ms, dauricine became more effective in lengthening APD at short cycle lengths. The effect of dauricine on prolonging APD exhibited normal use-dependence, whereas quinidine 1 mumol.L-1 and sotalol 10 mumol.L-1 were less effective in lengthening APD at short cycle lengths. The effect of quinidine and sotalol on APD exhibited reverse use-dependence. CONCLUSSION: The effect of dauricine on APD depends on activation frequency.  (+info)

Effect of tetrandrine on proto-oncogene c-fos expression in rat cerebrum. (3/274)

AIM: To detect the effect of tetrandrine (Tet) on c-fos gene expression in cerebrum induced by lindane, a neurotoxicant which activates Ca2+ channels. METHODS: Northern and dot blotting, dual wavelength thin layer chromatography scanner, were used in this study. RESULTS: Lindane 30 mg.kg-1 given by intragastric gavage (i.g.) increased the expression of c-fos gene to 146 mm2 in rat cerebrum 1 h after treatment. Tet 1, 2, and 4 mg.kg-1 given by i.g. 30 min prior to lindane reduced c-fos gene expression in a concentration-dependent manner. Expressed genes reached only 86, 40, and 39 mm2, respectively. CONCLUSION: Tet inhibited c-fos gene expression in rat cerebrum induced by Ca2+ agonist-lindane.  (+info)

Stimulation of pregnant rat uterine contraction by the polychlorinated biphenyl (PCB) mixture aroclor 1242 may be mediated by arachidonic acid release through activation of phospholipase A2 enzymes. (4/274)

The polychlorinated biphenyl (PCB) mixture Aroclor 1242 (A1242) increases frequency of contractions of pregnant rat uteri, suggesting a possible mechanism for decreased gestational age and increased spontaneous abortion in women and animals exposed to PCBs. In the present study, we hypothesized that A1242-induced stimulation of uterine contraction is mediated by arachidonic acid released by phospholipase A2 (PLA2) enzymes. Isometric uterine contraction was measured in longitudinal uterine strips isolated from gestation day 10 rat. Pretreatment of uterine strips with the PLA2 inhibitor (E)-6-(bromomethylene)tetrahydro-3-(1-naphthalenyl)-2H-pyran-2-one (HELSS) or manoalide, or an inhibitor of the G protein of PLA2, isotetrandrine, completely prevented the increase of contractile frequency induced by 50 microM A1242. However, the phospholipase C inhibitors 2-nitro-4-carboxyphenyl-N,N-diphenylcarbamate (NCDC) and neomycin were unable to block stimulation of uterine contraction by A1242. In accordance, A1242 (100 microM) did not release inositol phosphates from myo-[3H]inositol-labeled myometrial cells, whereas myometrial cells prelabeled with [3H]arachidonic acid released arachidonic acid in a concentration- and time-dependent manner after exposure to A1242 (10-100 microM). A1242 significantly stimulated arachidonic acid release in the absence of extracellular calcium, although the release was attenuated. Analysis of the eicosanoids released by A1242 indicated that only 0.83% of released [3H]arachidonic acid was metabolized to eicosanoids and 99.07% remained as free arachidonate. Uterine contraction increased in strips exposed to exogenous arachidonic acid (1-100 microM). This study suggests that A1242 stimulates contraction in pregnant rat uterus by a mechanism involving PLA2-mediated arachidonic acid release, and that arachidonic acid, rather than eicosanoids, may mediate A1242 uterotonic action in the uterus.  (+info)

Tetrandrine inhibited chronic "inflammatory" pulmonary hypertension in rats. (5/274)

AIM: To study the effects of tetrandrine (Tet), on pulmonary hypertension. METHODS: An "inflammatory" chronic pulmonary hypertension induced by monocrotaline (Mon) in rats was used. RESULTS: Tet 50, 100, and 150 mg.kg-1.d-1 i.g. 3 wk inhibited Mon-induced increase of pulmonary artery pressure (PAP) by 23.8%, 34.9% (P < 0.05), and 42.0%, (P < 0.05); the right heart index by 2.0%, 25.0%, and 30.0% (P < 0.05) respectively compared with those from Mon group, without significant influence on the systemic artery pressure (SAP). Using histological exam by Verhoeff elastic stain and computer scanning analysis, it was found that Tet (100 mg.kg-1.d-1) for 3 wk, inhibited the increase of medial thickness and cross sectional area by 57.8% (P < 0.01) and 54.6% (P < 0.01), respectively vs Mon group. CONCLUSION: Tet ameliorated the development of pulmonary vascular and lung tissue injury induced by Mon in rats.  (+info)

Dauricine inhibited L-type calcium current in single cardiomyocyte of guinea pig. (6/274)

AIM: To study the effect of dauricine (Dau) on L-type calcium current in guinea pig ventricular myocytes. METHODS: Using whole-cell recording method to record L-type calcium current (ICa) in single ventricular cell of guinea pig. RESULTS: Dau 1, 10, and 100 mumol.L-1 markedly reduced ICa by 15.2% +/- 2.2%, 41% +/- 5%, and 82% +/- 8%, respectively. After washing out, ICa partially recovered. Dau inhibited ICa at 3 Hz and 1 Hz to a similar extent, its effect on ICa appeared to be not frequency-dependent. CONCLUSION: Dau had a calcium channel blocking effect.  (+info)

Effects of anti-rheumatic herbal medicines on cellular adhesion molecules. (7/274)

OBJECTIVE: To test the hypothesis whether herbal medicines ameliorate inflammatory diseases via the modulation of cellular adhesion molecules (CAMs). METHODS: Human neutrophils, synovial fibroblasts, and endothelial cells were incubated with different concentrations of Tripterygium Wilfordii Hook-f (TWH-f) or Tetrandrine in the presence or absence of interleukin 1 (IL1). The amount of soluble E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cellular adhesion molecule-1 (VCAM-1) secreted by cells were determined by ELISA. The cell surface expression of these three CAMs was detected by flow cytometry. RESULTS: TWH-f at high concentration (50 ng/ml) has a significant (p<0.05) inhibitory effect on both the secretion and the expression of the cellular adhesion molecules. However, Tetrandrine did not demonstrate the same effects. CONCLUSIONS: The cellular adhesion molecules of the endothelium and leucocytes may constitute excellent targets for the development of new anti-inflammation medicines. These results indicate that TWH could be a potential therapeutic agent in the treatment of inflammatory diseases.  (+info)

Effects of N-methyl berbamine on delayed outward potassium current in isolated rat hepatocytes. (8/274)

AIM: To study the effects of N-methyl berbamine (NMB) on the delayed outward potassium currents (Ik) in isolated rat hepatocytes. METHODS: With patch-clamp techniques and whole-cell recording method, holding potential -50 mV, command potential +30 to +140 mV, duration 900 ms. RESULTS: NMB reduced Ik in a concentration-dependent manner. When the concentrations of NMB were 20, 50, 400 nmol.L-1 and 50 mumol.L-1, the amplitude values of Ik were decreased to 3.6 +/- 0.4 (P > 0.05), 2.1 +/- 1.6 (P > 0.05), 3.7 +/- 1.6 (P < 0.05), 2.3 +/- 1.3 nA (P < 0.01) from 4.4 +/- 1.0 (n = 4), 2.5 +/- 1.8 (n = 4), 5.8 +/- 2.1 (n = 5), 4.6 +/- 1.3 (n = 6) nA of control, respectively. The inhibitory rates were 10%, 15%, 37%, and 51%, respectively. CONCLUSION: NMB was a K+ channel inhibitor.  (+info)

Tetrandrine a bis-benzylisoquinoline alkaloid, is a calcium channel blocker. It has anti-inflammatory, immunologic and antiallergenic effects. It inhibits the degranulation of mast cells. It has a "quinidine-like" anti-arrhythmic effect. It has been isolated from Stephania tetrandra S Moore, and other Chinese and Japanese herbs. It has vasodilatory properties and can therefore reduce blood pressure. Tetrandrine may have potential use for the treatment of liver disease and liver cancer. Tetrandrine has potential therapeutic value to prevent excess scarring/fibrosis in conjunctiva following trabeculectomy or in patients with severe conjunctival inflammation. Tetrandrine has anti-inflammatory and anti-fibrogenic actions, which make tetrandrine and related compounds potentially useful in the treatment of lung silicosis, liver cirrhosis, and rheumatoid arthritis. Tetrandrine has also been shown to inhibit entry of Ebola virus into host cells in vitro and showed therapeutic efficacy against Ebola in ...
The isolated rat uterus contraction induced by oxytocin and Ca+ + after high-K depolarization were markedly inhibited by tetrandrine (Tet). The depression was immediately reversed by addition of Ca++ to the bath fluid. Tet and verapamil (Ver), which shifted the cumulative dose-response curves to the right and depressed the maximal responses to CaCl2 acted as non-competitive antagonists. The oxytocin-induced Ca++-dependent contractions were depressed by 4.8 and 30 μM Tet. Tet 30 μM also inhibited the Ca++ o-dependent component of the contraction. The effect of Ver on isolated rat uterus was stronger than that of Tet. But up to 0.05 μM, it showed no effect on Ca+ +-dependent oxytocin contraction. These results indicate that Tet is an effective Ca+ +-antagonist very similar to Ver on isolated rat uteri.
Isoliensinine, a natural phenolic bisbenzyltetrahydroisoquinoline alkaloid, has received considerable attention for its potential biological effects such as antioxidant and anti-HIV activities. From the dog hepatic microsomes of isoliensinine, three new N-demethylated and O-demethylated metabolites, 2-N-desmethyl-isoliensinine (M1), 2-N-desmethylisoliensinine (M2), and 2-N-6-O-didesmethylisoliensinine (M3), were identified by high-performance liquid chromatography and data-dependent electrospray ionization tandem mass spectrometry. Possible metabolic pathways for isoliensinine have been proposed. The result should prove very helpful for evaluation of the drug-like properties of isoliensinine and other bisbenzylisoquinoline alkaloids.
The effect of tetrandrine (518343) (TD) on enhancing the actions of the mutagens mitomycin-C (50077) (MMC) and cigarette smoke condensate (CSC) were examined. Chinese-hamster cell lines were exposed for 3 hours to: 20 microliters CSC; 40 or 80 micrograms/milliliter (microg/ml) TD; or 20, 40, or 80 microliters TD plus 20 microliters CSC without S9 activation. The cells were also exposed to 0.01micr
isotetrandrine drug combination cycleanine cepharanthine berbamine: an extract consisting of cepharanthine, cycleanine, isotetrandrine, and berbamine; isolated from Stephania cepharantha
Cardiac effects of the extract and active components of radix stephaniae tetrandrae. II. Myocardial infarct, arrhythmias, coronary arterial flow and heart rate in the isolated perfused rat heart ...
Cardiac effects of the extract and active components of radix stephaniae tetrandrae. II. Myocardial infarct, arrhythmias, coronary arterial flow and heart rate in the isolated perfused rat heart ...
Yu, H-Hua.; Mi, W-Ning.; Liu, B.; Zhao, H-Peng., 2016: In vitro and in vivo effect of paclitaxel and cepharanthine co-loaded polymeric nanoparticles in gastric cancer
Reperfusion is an essential treatment to salvage ischemia myocardium from necrosis. However, the reperfusion can also lead to additional damage. Ischemic preconditioning is a powerful way to initiate intrinsic adaptive responses protecting the heart from subsequent severe ischemia/reperfusion (I/R) injury that can be mimicked by pharmacological preconditioning. However, so far few agents are clinically available for patients with ischemia heart disease. There is a growing interest in exploring effective cardioprotective components extracted from Traditional Chinese Medicine because they have been practiced for thousands of years, providing a vast source of pharmaceutical materials. Berbamine, a kind of bisbenzylisochinoline alkaloids derived from the roots, barks and stems of Barberry, was reported to protect myocardium from ischemia/reperfusion (I/R) injury, but the underlying mechanisms are largely unknown. Here, we investigated whether berbamine confers cardioprotection via preventing calpain ...
Ebb and Flow Definition - An ebb and flow system, also known as a flood and drain system, is a popular hydroponic growing system where theres an...
Now £67 (Was £̶8̶3̶) on TripAdvisor: Ebb Tide Oceanfront Inn, Seaside. See 1,128 traveller reviews, 348 candid photos, and great deals for Ebb Tide Oceanfront Inn, ranked #12 of 27 hotels in Seaside and rated 4 of 5 at TripAdvisor.
Contact an Demi Moore booking agent now to discuss pricing & fees with an Demi Moore agent to book Demi Moore for corporate events, private parties & public concerts worldwide.
TY - JOUR. T1 - Neferine from Nelumbo nucifera induces autophagy through the inhibition of PI3K/Akt/mTOR pathway and ROS hyper generation in A549 cells. AU - Poornima, Paramasivan. AU - Weng, Ching Feng. AU - Padma, Viswanadha Vijaya. PY - 2013/12/15. Y1 - 2013/12/15. N2 - Previously we have reported that neferine from the medicinal plant Nelumbo nucifera, inhibited cancer cell proliferation by inducing apoptosis. The present study was focused on the action mechanism of neferine in inducing autophagy in lung cancer cells. Neferine markedly inhibited A549 cell proliferation in a dose dependent manner. Acidic vesicular accumulation was observed in neferine treated cells as an indication of autophagy. Neferine could induce the conversion of LC3B-I to LC3B-II without affecting the expression levels of PI3KCIII and Beclin1. It has been observed that neferine mediated autophagy is dependent on inhibition of PI3K/Akt/mTOR signaling by neferine. Neferine treatment could also lead to the ROS ...
Bisbenzylisoquinoline alkaloids were isolated from Stephania cepharantha Hayata and their proliferative activities on cultured hair cells from the murine skin were evaluated. Cepharanthine (1), cepharanoline (9), isotetrandrine (2), and berbamine (7) showed significant activities in the range of 0.01-0.1 microgram/ml, but had no activity on cultured keratinocytes or fibroblasts from the murine skin.
BioAssay record AID 680711 submitted by ChEMBL: TP_TRANSPORTER: increase in Rhodamine 123 intracellular accumulation (R123: 4 uM, Fangchinoline: 3 uM) in HCT15 cells.
Natural agents may be promising to combat aggressive behavior of the triple-negative breast cancer (TNBC). STAT3 is a protein that is highly expressed in breast cancer tissues compared to non-malignant breast tissues. Our objective for the present study is to analyze the anti-tumorogenic effects of a Chinese herbal drug, tetrandrine, in TNBC progression through inhibition of STAT3 phosphorylation.
Curine is a bisbenzylisoquinoline alkaloid (BBA) with anti-allergic, analgesic, and anti-inflammatory properties. Previous studies have demonstrated that this alkaloid is orally active at non-toxic doses. However, the mechanisms underlying its anti-inflammatory effects remain to be elucidated. This work aimed to investigate the effects of curine on macrophage activation and neutrophil recruitment. Using a murine model of lipopolysaccharide (LPS)-induced pleurisy, we demonstrated that curine significantly inhibited the recruitment of neutrophils in association with the inhibition of cytokines tumor necrosis factor (TNF-α), interleukin (IL)-1β, IL-6, monocyte chemotactic protein (CCL2/MCP-1) as well as leukotriene B4 in the pleural lavage of mice. Curine treatment reduced cytokine levels and the expression of iNOS in in vitro cultures of macrophages stimulated with LPS. Treatment with a calcium channel blocker resulted in comparable inhibition of TNF-α and IL-1β production, as well
When DArcy Wentworth Thompsons On Growth and Form was published 100 years ago, it raised the question of how biological forms arise during development and across evolution. In light of the advances in molecular and cellular biology since then, a succinct modern view of the question states: how do genes encode geometry? Our new special issue is packed with articles that use mathematical and physical approaches to gain insights into cell and tissue patterning, morphogenesis and dynamics, and that provide a physical framework to capture these processes operating across scales.. Read the Editorial by guest editors Thomas Lecuit and L. Mahadevan, as they provide a perspective on the influence of DArcy Thompsons work and an overview of the articles in this issue.. ...
Boc Sciences offers cas 118-08-1 (1R,9S)-(-)-β-Hydrastine in bulk,please inquire us to get a quote for 118-08-1 (1R,9S)-(-)-β-Hydrastine.
Tom Moore, Producer: Return to Boggy Creek. Tom Moore is a retired American film writer, producer, and director. Moore produced and directed more than a hundred TV commercials and multi-episode video series, but is best know for Return to Boggy Creek (1977). Moore worked in the Texas area with Director Charlie Pierce as a Line Producer on four films. The two met each other while working at a small TV station in El Dorado, Arkansas. Moore ...
Ebb lyrics by O.L.D.: Now I see / What I hate / Now I hate / What I see / See myself and what I hate / Now I hate / What I see / All must
Demi Moore Hospitalized, Seeking Professional Assistance Demi Moore is seeking professional assistance after being rushed to the hospital on Monday night (January 23). Paramedics responded to the 49-year-old actresss…
The narrowest part of the channel is less than 2km long, but takes a huge volume of water through on each tide. We reckoned that the actual slack water was less than five minutes before we began to feel the insistent pull of the ebb drawing us into the narrows. A few swirls and hydraulic cushions began to appear as the ebb started to establish but in the absence of swell things were very gentle ...
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Recently Congressman Mark Cojuangco has been quoting Moore, on the issue of nukes and I was wondering if had he not been formerly a part of Greenpeace would his opinion on the issue still count?. I recently stumbled upon this quote from Patrick Moore: ...
Model Mayhem is the #1 portfolio website for professional models and photographers. Create a profile, upload your photos and connect with other professionals
Model Mayhem is the #1 portfolio website for professional models and photographers. Create a profile, upload your photos and connect with other professionals
Tides are not formed along the entire coast of the seas and oceans, but only on those coasts with a high speed of currents. And the higher the speed of curre...
Tides are not formed along the entire coast of the seas and oceans, but only on those coasts with a high speed of currents. And the higher the speed of curre...
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I have been doing IT work for both residential and businesses for about 20 years. I recently started PC Networking & Moore in order to help provide support and expertise i...
Moore Medical offers a variety of education and training materials including anatomical charts and models, manikins and simulators, reference and field guides and more.
Moore Medical offers a variety of education and training materials including anatomical charts and models, manikins and simulators, reference and field guides and more.
Heres a video from Michael Moore, you know that fat film maker that gets grants from US to make films breading hate and discontent. Thought you all might like to see it. Because it made my neck hairs stand up. http://www.theblaze.com/stories/michael-moore-people-own-guns-because-theyre-fearful-racists/
ARTFINDER: Fire N Ice by Lucy Moore - I will ship Globally but please message me for a price I am very Proud of this piece of art work, the photographs dont do this piece any justice. This...
See what Christy Moore (respiratory03) has discovered on Pinterest, the worlds biggest collection of everybodys favorite things.
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Dont worry, were just as shocked as you are! Demi Moore shared a photo of her missing her two teeth and explains just how they fell out.
Demi Moore cannot catch a break! A photographer has filed a battery report against the actress, after he claimed that she struck him as he tried to snap some...
Carbon Nation Carbon Nation generates such an ebb and flow between predictions of doom and a green, sustainable future that the resulting wave power could sustain a small city.
And we learned...Cameron and I. Over months he began to adjust to the weight of the bow, the tension of the strings. I stood over him. I listened to the plink and pluck, the ebb and flow. At times picking up the miniature violin and instructing on what I perceived to be the right stance. I moved the bow back and forth awkwardly my body curled to meet the requirements of such a small instrument ...
A Story About Nothing Responsive web design offers us a way forward, finally allowing us to design for the ebb and flow of things.There are many variations of
Ellen enjoys working with our clients as they strive to provide their patients with the best care possible. She has a deep respect for those who dedicate their lives to improving the lives of others. She is honoured to be in a position where she can help them do that to their fullest potential.. ...
I kinda like him. Because I think hed be a solid competitor. As a person hes eh not terrible, the best one of the gbogh guys but the bar is already so so so low ...
Benzylisoquinoline alkaloids (BIAs) are a large group of nitrogen-containing specialized metabolites. Opium poppy (Papaver somniferum) is an important pharmaceutical plant and has been cultivated for thousands of years for its analgesic constituents: the morphinan BIAs codeine and morphine. In addition, opium poppy produces other BIAs with biological activities, such as the vasodilator papaverine, the potential anti-cancer drug noscapine and the antimicrobial agent sanguinarine. The objective of this work was to identify and characterize oxidative enzymes involved in BIA biosynthesis, with a specific focus on cytochromes P450 (P450s). The biosynthesis of sanguinarine from (S)-reticuline requires four P450s. Our first objective was to identify these unidentified P450s in opium poppy. Our approach was based on the coordinated induction of all sanguinarine biosynthetic enzyme transcripts and proteins in elicited opium poppy cell suspension cultures. Using data from a previous microarray study, we ...
Preparation and characterization of tetrandrine-phospholipid complex loaded lipid nanocapsules as potential oral carriers Yi-qing Zhao, Li-ping Wang, Chao Ma, Kun Zhao, Ying Liu, Nian-ping FengSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, Peopleâ s Republic of ChinaBackground: Tetrandrine is an active constituent that is extracted from the root tuber of the Chinese herb Stephania tetrandra S. Moore. It has shown various pharmacological effects, such as antitumor activity, multidrug resistance reversal, and hepatic fibrosis resistance. In clinical applications, it has been used to treat hypertension, pneumosilicosis, and lung cancer. However, the poor water solubility of tetrandrine has limited its application. In this study, a newly emerging oral drug carrier of phospholipid complex loaded lipid nanocapsules was developed to improve the oral bioavailability of tetrandrine.Methods: The phospholipid complex was prepared with the solvent-evaporation method to enhance
Tetrandrine protects mouse retinal ganglion cells from ischemic injury Weiyi Li,1,2 Chen Yang,2 Jing Lu,2 Ping Huang,1 Colin J Barnstable,2 Chun Zhang,1 Samuel S Zhang2,3 1Department of Ophthalmology, Peking University Third Hospital, Peking University Eye Center, Beijing, People's Republic of China; 2Department of Neural and Behavioral Sciences, Penn State University, Hershey, PA, USA; 3Singapore Eye Research Institute, Singapore National Eye Centre, Singapore Abstract: This study aimed to determine the protective effects of tetrandrine (Tet) on murine ischemia-injured retinal ganglion cells (RGCs). For this, we used serum deprivation cell model, glutamate and hydrogen peroxide (H2O2)-induced RGC-5 cell death models, and staurosporine-differentiated neuron-like RGC-5 in vitro. We also investigated cell survival of purified primary-cultured RGCs treated with Tet. An in vivo retinal ischemia/reperfusion model was used to examine RGC survival after Tet administration 1 day before ischemia. We found
chemBlink provides information about CAS # 524-20-9, (-)-Armepavine, (R)-(-)-Armepavine, Alkaloid D, from Evonymus europaea, Evoeuropine, NSC 110381, 4-[[(1R)-1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl]methyl]phenol, molecular formula: C19H23NO3.
Previous studies have utilized monoamine oxidase (MAO) and L-3,4-dihydroxyphenylalanine decarboxylase (DDC) for microbe-based production of tetrahydropapaveroline (THP), a benzylisoquinoline alkaloid (BIA) precursor to opioid analgesics. In the current study, a phylogenetically distinct Bombyx mori 3,4-dihydroxyphenylacetaldehyde synthase (DHPAAS) is identified to bypass MAO and DDC for direct production of 3,4-dihydroxyphenylacetaldehyde (DHPAA) from L-3,4-dihydroxyphenylalanine (L-DOPA). Structure-based enzyme engineering of DHPAAS results in bifunctional switching between aldehyde synthase and decarboxylase activities. Output of dopamine and DHPAA products is fine-tuned by engineered DHPAAS variants with Phe79Tyr, Tyr80Phe and Asn192His catalytic substitutions. Balance of dopamine and DHPAA products enables improved THP biosynthesis via a symmetrical pathway in Escherichia coli. Rationally engineered insect DHPAAS produces (R,S)-THP in a single enzyme system directly from L-DOPA both in vitro ...
Dear Stephen, In Healing Lyme you state that stephania is not recommended for people on beta blockers. Why? What would happen then?
The obituary published in The Sporting News when Gene Moore died centered on his having made his only World Series appearance because of "a weird circumstance."1 Although accurate, the article overlooked the fact that Moore was a player of All-Star caliber, the type of player any manager would want on his team. Statistics did not reflect the intensity Moore brought to baseball.. The "weird circumstance" The Sporting News cited was a trade of catchers between the Washington Senators and the St. Louis Browns in March 1944, Washingtons Tony Giuliani for the Browns Rick Ferrell. Giuliani refused to go to the lowly Browns and instead retired. Moore was substituted for Giuliani. He too was reluctant to go to St. Louis for whom little success was forecast in 1944, and did so only after receiving a cash inducement from the Senators. So it was Moore rather than Giuliani who earned a World Series check that season.. Eugene Moore, Jr. was born in Lancaster, Texas, on August 26, 1909, to Eugene and Sarah ...
Botanicare: BOTANICARE ECONO JET 2 X 2 EBB & FLOW GROWING SYSTEM - 30.5 inch X 23.25 inch X 18 inch [706250] - Hydroponic Systems - Grow Systems - Gardening & Hydroponics Store -
A few years ago I was introduced to this weird ass band out of ol San Fran called Howls of Ebb, and I decided to investigate. Unfortunately, at the time I had yet to really get into death metal of any kind, but almost a year later I saw the band release a new record…
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Who was Mary Tyler Moore? How did she die? Facts about Mary Tyler Moore, her net worth in 2018, her real height, husband, boyfriend and kids.
... - So I love all the Teesha Moore projects floating around and wanted to try it. My goal is to make a Star Trek one, but wanted a quick practice pr
This brings me to Bob Fosses Cabaret (1972), his film version of John Kander and Fred Ebbs 1966 Broadway musical, which was, in turn, adapted from two other sources. One of the best-known songs from the 1930s Germany-set musical is "Tomorrow Belongs to Me," an anthem-like song belted out in English by a Hitlerjunge to an audience of other Germans in a Biergarten. When I watch this scene on stage, I can accept this characters incongruous use of the English language, placed against the artificiality of the stages set design, as a contrivance needed to communicate with the English-speaking audience. However, in the naturalistic setting of Fosses film, this Nazi singing to other Germans in English strikes me as a supremely surrealistic moment: hes calling for national pride by singing in the language of another nation. As euphonious as Fred Ebbs lyrics are, I dont think that they are absolutely necessary to the scene. In fact, given that the scene is supposed to convey the rising of a ...
Trevor Moore - What About Mouthwash? Lyrics. Me and Jesses cousin Went to the Chevron after work To grab a couple sixers and some beefy jerk. The man behind the counter Said hed like
A judicial panel last month suspended Alabama Chief Justice Roy Moore for the remainder of his term after finding he urged state probate jud…
Worcestershire opening batsman Stephen Moore has signed a new three year contract with the club which will see him through to the end of the 2011 season.
mnamd.com - metropolitan neurosurgery associates - dr. steinberger, dr. moore, dr. arginteanu, dr. yao, dr. gologorsky, expert neurosurgeons, with offices in nj and ny.
Erin C. Moore, MD is a specialist in Dermatology who has an office at 904 7th Avenue Floor 6 in Seattle, WA and can be reached at 206-860-4605.
Trevor Moore - Founding Fathers (Intro) Lyrics. The name is George Washington but thats the general to you. Or you could president one, not three or two. And you probably heard a lot of s
Assistant Management Accountant in Permanent, £25,000 - £29,999, Experienced, non-manager, Finance & Accounts with Axon Moore. Apply Today.
By the time Chevrolet made the ZL1 option available for the Camaro in 1969, the muscle car era was starting to ebb. But it turned out to be one of the most storied V-8 engines of the era.
There is an intimate relationship we have with our own body. We understand the natural ebbs and flows of our specific biorhythms. Sometimes we need to take a bit of a break from reality and shut down.
Allah be, işte bu senenin pırlanta albümü. Hardcorecul bir arka fon üzerine ikinci gitarla yaratılan acayip atmosferin içinde coşkulu vokaller oturtulunca böyle bir başyapıt çıkmış. Our Own Ebb and Flowun iyimser melodikliğiyle Fatherın koyu karanlığı birbirlerini takip ederken en ufak biçimde sırıtmıyorlar. Winter Wasteland ise geride bırakıyor olduğumuz senenin en acayip şarkılarından biri. Başka şey dinleyemez oldum -o kadar iyi bir kayıt işte. ...
By Roger Friedman hollywoodnews.com: Chemistry is everything in the movies, and everything at the box office. The current low ebb of films and audiences is just a bad mix. Currently a half dozen films are just mediocre enough to cause not a scintilla of a spark anywhere on this hot, humid weekend. They ...
IMDbs advanced search allows you to run extremely powerful queries over all people and titles in the database. Find exactly what youre looking for!
Wasniewski, M. Almeida, I., Baur, A., Bedekovic, T., Boncea, D., Bothelho Chaves, L. David, D., De Benedictis, P., Dobrostana, M., Giraud, P. Hostnik, P., Jaceviciene, I., Kenklies, S., König, M., Mähar, K., Mojzis, M., Moore, S. Mrenoski, S., Müller, T., Ngoepe, E., Nishimura, M., Nokireki, T., Pejovic, N., Smreczak, M., Strandbygaard, B., Wodak, E., Cliquet, F ...
Bună sara! Ne-am mutat la casâ nouâ șî am zâs câ ar fi ghini sâ vă cinstesc oleacă! Am pentru voi o sacoșâ cu dulșiuri șî niști bieri. Aș fi vrut sâ vă dau o tavâ cu poale-n brâu șî Continue reading Bre, dam premii pi digeaba!→. ...
Bună sara! Ne-am mutat la casâ nouâ șî am zâs câ ar fi ghini sâ vă cinstesc oleacă! Am pentru voi o sacoșâ cu dulșiuri șî niști bieri. Aș fi vrut sâ vă dau o tavâ cu poale-n brâu șî Continue reading Bre, dam premii pi digeaba!→. ...
Brand and generic products.. Buy Lotus Leaf And Weight Loss Nelumbo Nucifera - buy and save money.. Lotus Leaf And Weight Loss Nelumbo Nucifera.. No prescription Lotus Leaf And Weight Loss Nelumbo Nucifera, Buy online pharmacy Lotus Leaf And Weight Loss Nelumbo Nucifera..
Looking for online definition of Stephania japonica in the Medical Dictionary? Stephania japonica explanation free. What is Stephania japonica? Meaning of Stephania japonica medical term. What does Stephania japonica mean?
Today, we suffer from unprecedented pollution. No wonder the skin begins to look dull and aged soon. And to make things worse, the use of cosmetics harms our skin unknowingly. The solution lies in using natural ingredients. That is the reason why more and more people are turning towards herbal products to keep their skin healthy and beautiful. Nelumbo nucifera or lotus is one of the natural ingredients that can be used to get healthy skin. Some of the benefits of lotus root for the skin are:. 1. Rich in Antioxidants:. Rich in antioxidants, the fragrant Nelumbo nucifera acts as a skin conditioner.. [ Read: Best Sources Of Antioxidants ]. 2. Acts as a Moisturising Agent:. Its properties intensely hydrates and moisturises the skin and helps in increasing skin elasticity and complexion, erasing fine lines, fading brown spots and wrinkles.. 3. Heals Flaky and Dry Skin:. Many cosmetic and skin care products use nelumbo nucifera as their leading ingredients. It provides instant hydration to the skin. ...
Lotus Root (Nelumbo nucifera; Lian Ou) Whole: 500 gm (1.17 lb): V (Special Order)-Lotus Root (Nelumbo nucifera; Lian Ou) Whole: 500 gm (1.17 lb): V (Special ....Learn More At Kalyx.com.
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Ebb and flow systems are flexible, with few practical drawbacks. Though typically known for compact cultivation of plants having smaller stature, it has been used for growing large plants, using buckets ranging in size from 1 gallon to 5 gallons, making use of high-volume pumps such as those in large aquariums, decorative fountains and koi ponds. There are facets to these systems that present some labor investment in large-scale applications. These are primarily management of media between uses, such as washing and sterilization. This can be done by dumping into the tray and filling with a sterilizing solution such as hydrogen peroxide or chlorine solution, temporarily plugging the drain, with hand removal of root fragments. Larger containers require transferring the media to a suitable surface after sterilization to permit removal of leftover plant material. A second drawback is that the roots tend to grow together, meaning removal of harvested or damaged plants can be somewhat problematic in ...
APG IV Classification: Domain: Eukaryota • (unranked): Archaeplastida • Regnum: Plantae • Cladus: angiosperms • Cladus: eudicots • Cladus: core eudicots • Cladus: superrosids • Cladus: rosids • Cladus: eurosids I • Cladus: COM • Ordo: Malpighiales • Familia: Passifloraceae • Genus: Tetrapathea • Species: Tetrapathea tetrandra (Banks ex DC.) Cheeseman (1925) ...
Norcoclaurine HCl (Norcoline TM ) Effective as a stimulant or not? Ive been seeing it a bit more in Supplements, wondering its effectiveness, if any
Despite the differences in sound and style, KHTHONIIK CERVIIKS and HOWLS OF EBB have in common a creative approach that bestows uniqueness and originality to their songwriting. They are never too pretentious and never betray their ancient metal roots. On the contrary, they exalt and glorify the most primeval, instinctual and scariest elements of metal through their unbridled visionary talent, making metal wild and dangerous once again.. ...
Despite the differences in sound and style, KHTHONIIK CERVIIKS and HOWLS OF EBB have in common a creative approach that bestows uniqueness and originality to their songwriting. They are never too pretentious and never betray their ancient metal roots. On the contrary, they exalt and glorify the most primeval, instinctual and scariest elements of metal through their unbridled visionary talent, making metal wild and dangerous once again.. ...
Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues / S Mo; D H Kim; J H Lee; J W Park; D B Basnet; Y H Ban; Y J Yoo; S Chen; S R Park; E A Choi; E Kim; Y Y Jin; S K Lee; J Y Park; Y Liu; M O Lee; K S Lee; S J Kim; Doo Il Kim; Byoung Chul Park; S G Lee; H J Kwon; J W Suh; B S Moore; S K Lim; Y J Yoon , 2011 ...
Best Syndication News) Mary Tyler Moore and Dick Van Dyke were on the Rachael Ray show discussing their antics on The Dick Van Dyke Show. Van Dyke was reminiscing about the first time they met when the 74-year old Moore made a surprise entrance.. They recreated the 1970s set and reminisced. Van Dyke said that he might have been a little in-love with Moore back when they were on the show; but in those days they didnt act on their mutual attraction. The star of "Ordinary People" was rumored to have a benign tumor called meningioma. Back in July of 2007, the Globe broke the story. Moores representative now tells People Magazine that the star will undergo surgery to remove the growth. They are calling the procedure "fairly routine." ...
Alkaloids are traditionally defined as basic (alkali‐like), nitrogen‐containing organic constituents that occur mainly in plants
Visit Dr. Michelle S. Moore, critical care specialist, palliative care physician, internist & pulmonologist in Santa Clara, CA. Are you Dr. Moore? Sign up for MD.com.
Local and state police Thursday morning raided a home in Moore Township looking for evidence of a methamphetamine lab but said they found only a small amount of drugs.Moore police and members of a
Roy Moore has been targeted by the Illuminati - its the only explanation. View Heres What Happened At the Anti-Roy Moore Conspiracy Meeting and more funny posts on CollegeHumor
We carry Gunn & Moore cricket bats 2013 in the size and weight you need. Browse our site and see for yourself! Give us a call with any questions.
Maximize muscle tone and gain strength by training your nervous system with frequent low volume workouts. Visual Impact Frequency Training by Rusty Moore.
Maximize muscle tone and gain strength by training your nervous system with frequent low volume workouts. Visual Impact Frequency Training by Rusty Moore.
Courtesy of our pals at iOwnTheWorld, who have more heart and artistic ability in their toenail clippings than Moore has in his rather rotund carcass. And I say that with all due respect to rotund carcasses in general ...
Check out Fabric Editions Decorative Storage & Gift Jars crafting ideas at A.C. Moore. Explore many more such exceptional art & craft products only here.
Wonder what makes a healthy knee? Dr. John Moore gives you information about the minerals found in a health knee. Call for more information.
Nearly 30 years of experience and four jobs in corporate security, including his current post as executive director of global security at Merck & Co., and not once has Bob Moore been let go, laid off, fired or otherwise left to pursue other interests, as the transparent euphemism goes.
Ryan Moore (pictured) defeated Gary Woodland on the only playoff hole needed on Monday to decide the champion of the CIMB Classic.
Benzylisoquinoline alkaloids (BIAs) are important secondary plant metabolites and include medicinally relevant drugs, such as morphine or codeine. As the de novo synthesis of BIA backbones is (still) unfeasible, to date the opium poppy plant Papaver somniferum L. represents the main source of BIAs. The formation of BIAs is induced in poppy plants by stress conditions, such as wounding or salt treatment; however, the details about regulatory processes controlling BIA formation in opium poppy are not well studied. Environmental stresses, such as wounding or salinization, are transduced in plants by phospholipid-based signaling pathways, which involve different classes of phospholipases. Here we investigate whether pharmacological inhibition of phospholipase A2 (PLA2, inhibited by aristolochic acid (AA)) or phospholipase D (PLD; inhibited by 5-fluoro-2-indolyl des-chlorohalopemide (FIPI)) in poppy plants influences wound-induced BIA accumulation and the expression of key biosynthetic genes. We show ...
Dried poppy pods are most commonly referred to as Papaver Somniferum which is world renowned for its beautiful flowers and edible seeds. Dried opium poppy pods have frequently been used for medicinal, culinary and sometimes even recreational purposes throughout the ages. One of the main reasons that are associated with the popularity of these opium poppies is the fact that they are also the primary ingredient of many opiates with sedative properties.. If you have ever bought poppy pods you will notice that they are some of the most beautiful flowers you will ever find in a garden. Many types of these poppies are widely available in various colours which include blue, yellow, orange, pink, red, white, purple, and even blue. You can grow your own unique poppies in your outdoor or indoor garden.. Many of these particular species of poppy flowers are frequently utilized in both medicines and food. The most sought after species being that of the opium poppy pod. Dried opium poppy pods contain opium ...
Nelumbo nucifera Gaertn, belonging to the family Nymphaeaceae, commonly known as lotus, is a perennial aquatic plant distributed over the world, especially in India, China, Japan, Korea, Russia, and some African countries. The seeds of N. nucifera have been used as traditional medicine for treatment of nervous disorders, insomnia, high fevers, hematemesis, hematuria, hypertension, and stopping of bleeding. There have been many biological reports on the Nelumbinis Semen, however, its biological principles have not been studies intensively. Therefore, the dried Nelumbinis Semen were subjected to detailed laboratory phytochemical investigation. Four compounds 45-48 were isolated from the EtOAc extracts (300 g) and identified as 4-hydroxybenzoic acid methyl ester, 4-hydroxybenzoic acid ethyl ester, 4-hydroxybenzoic acid propyl ester, and 4-hydroxybenzoic acid butyl ester, respectively, by comparison of their spectral data with the published values. In addition, the paraben derivatives 45-48 were ...
well my front step poppy finally bloomed,and its a lovely, full pink peoniflorum. and now have no idea where the seed came from. it certainly diddnt come from the bulk seed of albums and nigrums
Papaver somniferum is the quintessential Moon plant because of its sedative effects, its milky sap, the shape of its pods--even the petals have something Moonish about them. But the presence of iron and copper means that P. somniferum is also ruled by both Mars and Venus, which well corresponds to poppy qualities as both stimulating and sedating, male and female, brain and body, physical and intellectual. The poppy is often associated with both remembrance and forgetting, and its huge ovary filled with thousands of seeds makes a good symbol for female fertility. Some consider a dried pod full of seeds to be an excellent amulet for attracting wealth also.
Burger A (2005) [1954]. "The Benzylisoquinoline Alkaloids". In Manske RH, Holmes HL. The Alkaloids: Chemistry and Physiology. 4 ...
... is an antimicrobial benzylisoquinoline alkaloid. Villar, A; Mares, M; Rios, JL; Canton, E; Gobernado, M (1987). " ... "Antimicrobial activity of benzylisoquinoline alkaloids". Die Pharmazie. 42 (4): 248-50. PMID 3615557. ...
Structurally, tubocurarine is a benzylisoquinoline derivative. For many years, its structure, when first elucidated in 1948, ...
BIAdb: A Database for Benzylisoquinoline Alkaloids. The Benzylisoquinoline Alkaloid Database is an attempt to gather the ... A curated database of benzylisoquinoline alkaloids". BMC Pharmacology. 10: 4. doi:10.1186/1471-2210-10-4. PMC 2844369 . PMID ...
McCorkindale NJ, Magrill DS, Martin-Smith M, Smith SJ, Stenlake JB (1964). "Petaline: A 7,8-dioxygenated benzylisoquinoline". ...
"Microbial production of plant benzylisoquinoline alkaloids". Proceedings of the National Academy of Sciences. 105 (21): 7393- ...
Hawkins KM, Smolke CD (September 2008). "Production of benzylisoquinoline alkaloids in Saccharomyces cerevisiae". Nature ...
The first committed enzyme in benzylisoquinoline alkaloid biosynthesis in plants". J. Biol. Chem. 277 (37): 33878-83. doi: ... Stadler R, Kutchan TM, Zenk MH (1989). "(S)-Norcoclaurine is the central intermediate in benzylisoquinoline alkaloid ... This enzyme participates in benzylisoquinoline alkaloid biosynthesis. Stadler R, Zenk MH (1990). "A revision of the generally ...
It is a type of benzylisoquinoline alkaloid; benzylisoquinoline alkaloids have medical uses such as analgesic or anticancer ...
It is based on the benzylisoquinoline structure. Reticuline is one of the alkaloids found in opium, and experiments in rodents ...
Bloodroot produces benzylisoquinoline alkaloids, primarily the toxin sanguinarine. The alkaloids are transported to and stored ... also produce such benzylisoquinoline alkaloids. Plant geneticists have identified and sequenced genes which produce the enzymes ...
Rueffer M; Zenk MH (1987). "Distant precursors of benzylisoquinoline alkaloids and their enzymatic formation". Z. Naturforsch. ...
... a bis-benzylisoquinoline alkaloid, is a calcium channel blocker. It has anti-inflammatory, immunologic and ... 2009 Oct;32(20):3550-4 Kwan CY, Achike FI.,"Tetrandrine and related bis-benzylisoquinoline alkaloids from medicinal herbs: ... 2008 Jul;33(7):559-65 Kwan CY, Achike FI.,"Tetrandrine and related bis-benzylisoquinoline alkaloids from medicinal herbs: ...
... is a benzylisoquinoline alkaloid with two additional ring closures. It has: A rigid pentacyclic structure consisting ...
Also, marks a branch point in the biosynthesis of benzylisoquinoline alkaloids. As mentioned above, BBE-like enzymes are in the ...
Benzylisoquinoline alkaloids include aporphines and oxoaporphines, as well as derivatives of morphinans. Essential oils include ...
Benzylisoquinoline alkaloids (BIAs) are a structurally diverse group of plant specialized metabolites with a long history of ... Hagel, J. M, & Facchini, P. J. (2013). Benzylisoquinoline Alkaloid Metabolism: A Century of Discovery and a Brave New World. ...
1-Benzylisoquinoline is the structural backbone in naturally occurring alkaloids including papaverine. The isoquinoline ring in ...
Benzylisoquinolines, such as atracurium and tubocurarine, the other major group of neuromuscular blocking agents Ted Lin; Tim ...
Most important were the benzylisoquinoline-aporphine derivatives, a relatively new group of alkaloids. The results obtained ...
... and benzylisoquinolines (including papaverine). Of these, morphine is the most prevalent comprising 8%-14% of the total. Its ...
2007) Identification of a WRKY Protein as a Transcriptional Regulator of Benzylisoquinoline Alkaloid Biosynthesis in Coptis ...
... and its derivatives such as oxaline are bio-active benzylisoquinoline alkaloids made by deep ocean Penicillium. ...
"Anti-HIV benzylisoquinoline alkaloids and flavonoids from the leaves of Nelumbo nucifera, and structure-activity correlations ...
"Anti-HIV benzylisoquinoline alkaloids and flavonoids from the leaves of Nelumbo nucifera, and structure-activity correlations ...
Typical natural products found in this genus are benzylisoquinoline alkaloids such as magnoflorine and the structurally related ...
Mechanism-based tuning of insect 3,4-dihydroxyphenylacetaldehyde synthase for synthetic bioproduction of benzylisoquinoline ... a benzylisoquinoline alkaloid (BIA) precursor to opioid analgesics. In the current study, a phylogenetically distinct Bombyx ...
Benzylisoquinoline alkaloids (BIAs) are a large group of nitrogen-containing specialized metabolites. Opium poppy (Papaver ... Characterization of Oxidative Enzymes Involved in the Biosynthesis of Benzylisoquinoline Alkaloids in Opium Poppy (Papaver ...
... composed of two benzylisoquinoline units) Morphinan Benzylisoquinoline biosynthesis by cultivated plant cells and isolated ... 1-Benzylisoquinoline is a chemical compound, and the structural backbone of many alkaloids with a wide variety of structures, ... Plants producing benzylisoquinoline alkaloids have a common biosynthetic pathway, making use of two units of L-tyrosine. One ... Many benzylisoquinolines have a methylated nitrogen atom as well as functional groups containing oxygen (−OH, −OCH3, −OCH2O−) ...
What is benzylisoquinolines? Meaning of benzylisoquinolines medical term. What does benzylisoquinolines mean? ... Looking for online definition of benzylisoquinolines in the Medical Dictionary? benzylisoquinolines explanation free. ... benzylisoquinolines. ben·zyl·i·so·quin·o·lines. (benzil-īsō-kwinō-linz), A group of alkaloids found primarily in poppy ... Selective inhibition of calcium entry induced by benzylisoquinolines in rat smooth muscle was studied (Catret et al. ...
... known for biosynthesis of several therapeutically important benzylisoquinoline alkaloids (BIAs), has emerged as the premier ... Beaudoin GAW, Facchini PJ (2014b) Benzylisoquinoline alkaloid biosynthesis in opium poppy. Planta 240:19-32CrossRefPubMedGoogle ... Benzylisoquinoline alkaloids Biosynthetic pathway Cultivars Papaver somniferum Transcription factors Transcriptome data ... Beaudoin GA, Facchini PJ (2014a) Benzylisoquinoline alkaloid biosynthesis in opium poppy. Plant J 240:19-32CrossRefGoogle ...
Conclusion:: Calabadion 1 is a new drug for rapid and complete reversal of the effects of steroidal and benzylisoquinoline ... Calabadion 1 is an experimental agent that binds to steroidal and benzylisoquinoline neuromuscular blockers, but its in vivo ... Calabadion: A New Agent to Reverse the Effects of Benzylisoquinoline and Steroidal Neuromuscular-blocking Agents. ... Accordingly, we thought that calabadions would display excellent affinity toward both steroidal and benzyl isoquinoline NMBAs ...
Benzylisoquinoline. Cissampelos pareira contains benzylisoquinoline that exerts nootropic activity in AD. It is a memory- ... A novel series of benzylisoquinoline derivatives have also been evaluated. The results have shown that most of the compounds ... synthesis and biological evaluation of benzylisoquinoline derivatives as multifunctional agents against Alzheimers disease. ...
Modulation of benzylisoquinoline alkaloid biosynthesis by overexpression berberine bridge enzyme in Macleaya cordata *Peng ... Hairy root induction and benzylisoquinoline alkaloid production in Macleaya cordata *Peng Huang ... Rights & permissionsfor article Hairy root induction and benzylisoquinoline alkaloid production in ,i,Macleaya cordata,/i, . ... Rights & permissionsfor article Modulation of benzylisoquinoline alkaloid biosynthesis by overexpression berberine bridge ...
Chapter 2. The Benzylisoquinolines. I. Introduction II. Degradation of Laudanosine, A Tetrahydro Benzylisoquinoline Alkaloid ... Syntheses of Spiro Benzylisoquinolines IV. The Protoberberine-,Spiro Benzylisoquinoline-,Dibenzo Cyclopent[b]- azepine ... Structural Elucidation of Takatonine, A Quaternary Benzylisoquinoline Alkaloid IV. Petaline, A Tetrahydro Benzylisoquinoline of ... Some Reactions of Benzylisoquinolines VIII. Absolute Configuration IX. Biosynthesis X. Pharmacology XI. A Possible Biochemical ...
Modulation of benzylisoquinoline alkaloid biosynthesis by overexpression berberine bridge enzyme in Macleaya cordata *Peng ... Rights & permissionsfor article Modulation of benzylisoquinoline alkaloid biosynthesis by overexpression berberine bridge ...
Benzylisoquinolines. *Cardiovascular Agents. *Chemical Actions and Uses. *Drugs for Functional Gastrointestinal Disorders ...
TROCHODENDRALES [BUXALES + CORE EUDICOTS]]: benzylisoquinoline alkaloids 0; euAP3 + TM6 genes [duplication of paleoAP3 gene: B ... CHLORANTHALES + MAGNOLIIDS] [MONOCOTS [CERATOPHYLLALES + EUDICOTS]]] / MESANGIOSPERMAE: benzylisoquinoline alkaloids +; ...
... benzylisoquinoline alkaloids 0, hemicelluloses as xylan, cell wall also with (1->3),(1->4)-ß-D-MLGs [Mixed-Linkage Glucans]; ... CHLORANTHALES + MAGNOLIIDS] [MONOCOTS [CERATOPHYLLALES + EUDICOTS]]] / MESANGIOSPERMAE: benzylisoquinoline alkaloids +; ...
Benzylisoquinoline alkaloids (BIAs) represent a diverse class of plant specialized metabolites sharing a common biosynthetic ... Benzylisoquinoline alkaloid metabolism: a century of discovery and a brave new world. Plant Cell Physiol. 2013;54:647-72.View ... Production of benzylisoquinoline alkaloids in Saccharomyces cerevisiae. Nat Chem Biol. 2008;4:564-73.Google Scholar. ... Systematic silencing of benzylisoquinoline alkaloid biosynthetic genes reveals the major route to papaverine in opium poppy. ...
Benzylisoquinoline alkaloids from Anisocycla cymosa roots. Planta Medica 55: 394.PubMedCrossRefGoogle Scholar ...
Structurally, tubocurarine is a benzylisoquinoline derivative. For many years, its structure, when first elucidated in 1948, ...
Mivacurium (Benzylisoquinolines) - competitive neuromuscular receptor blocker (AchR). - little muscarinic or ganglionic AchR ...
0 (Alkaloids); 0 (Benzylisoquinolines); 0 (Glycosides); 0 (Iridoids); 0 (Monoterpenes); 0 (Tetrahydroisoquinolines); 56W89FBX3E ...
A bis-benzylisoquinoline alkaloid for use with chemotherapy for refractory and relapsed acute myeloid leukemia (AML). Saira ... Saira Bates / A bis-benzylisoquinoline alkaloid for use with chemotherapy for refractory and relapsed acute myeloid leukemia ( ...
Burger A (2005) [1954]. "The Benzylisoquinoline Alkaloids". In Manske RH, Holmes HL. The Alkaloids: Chemistry and Physiology. 4 ...
Hairy root induction and benzylisoquinoline alkaloid production in Macleaya cordata.. Huang P, Xia L, Liu W, Jiang R, Liu X, ...
2008) Microbial production of plant benzylisoquinoline alkaloids. Proc Natl Acad Sci USA 105:7393-7398. ... 2008) Production of benzylisoquinoline alkaloids in Saccharomyces cerevisiae. Nat Chem Biol 4:564-573. ...
Benzylisoquinolines. Direct Parent. Benzylisoquinolines. Alternative Parents. Dimethoxybenzenes / Phenoxy compounds / Anisoles ... benzylisoquinoline alkaloid, dimethoxybenzene, isoquinolines (CHEBI:28241) / Isoquinoline alkaloids (C06533) Targets. Details1 ... Benzylisoquinoline / O-dimethoxybenzene / Dimethoxybenzene / Phenoxy compound / Anisole / Phenol ether / Methoxybenzene / Alkyl ... This compound belongs to the class of organic compounds known as benzylisoquinolines. These are organic compounds containing an ...
Study Pharm flashcards from Tina Jaramillo
The benzylisoquinoline alkaloid group includes papaverine. The phthalide isoquinoline alkaloid group includes narcotine, ...
  • Selective inhibition of calcium entry induced by benzylisoquinolines in rat smooth muscle was studied (Catret et al. (thefreedictionary.com)
  • Anselmi E, Fayos G, Blasco R, Candenas L, Cortes D, D'Ocon MP (1991) Selective inhibition of calcium entry induced by benzylisoquinolines in rat smooth muscle. (thefreedictionary.com)
  • Among nitro-containing metabolites, the aristolochic acids are a family of substituted 10-nitro-1-phenantropic acids, biogenetically derived from benzylisoquinoline precursors, which in turn originate from tyrosine amino acid (Michl et al. (thefreedictionary.com)
  • Therefore, in addition to presenting the first RNA aptamers to a subclass of benzylisoquinoline alkaloid molecules, this work highlights a method for characterizing small molecule aptamers that is more robust, precise, rapid and high-throughput than other commonly employed techniques. (nih.gov)