Toluenes in which one hydrogen of the methyl group is substituted by an amino group. Permitted are any substituents on the benzene ring or the amino group.
The highest dosage administered that does not produce toxic effects.
An aspect of monoamine oxidase, EC 1.4.3.4. Catalyzes the oxidation of benzylamine to form benzaldehyde, ammonia and hydrogen peroxide.
Experiments designed to determine the potential toxic effects of one-time, short-term exposure to a chemical or chemicals.
Societies whose membership is limited to scientists.
A plant species of the genus ARTEMISIA, family ASTERACEAE that has been used in ABSINTHE. The oil contains neurotoxic 1-thujone and d-isothujone.
An array of tests used to determine the toxicity of a substance to living systems. These include tests on clinical drugs, foods, and environmental pollutants.
An organizational enterprise between a public sector agency, federal, state or local, and a private sector entity. Skills and assets of each sector are shared to deliver a service or facility for the benefit or use of the general public.
A group of QUINOLONES with at least one fluorine atom and a piperazinyl group.
The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.
Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.
A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dictionary, 5th ed)
Freedom from exposure to danger and protection from the occurrence or risk of injury or loss. It suggests optimal precautions in the workplace, on the street, in the home, etc., and includes personal safety as well as the safety of property.
Unforeseen occurrences, especially injuries in the course of work-related activities.
Toxic, volatile, flammable liquid hydrocarbon byproduct of coal distillation. It is used as an industrial solvent in paints, varnishes, lacquer thinners, gasoline, etc. Benzene causes central nervous system damage acutely and bone marrow damage chronically and is carcinogenic. It was formerly used as parasiticide.
A widely used industrial solvent.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).
A rigorously mathematical analysis of energy relationships (heat, work, temperature, and equilibrium). It describes systems whose states are determined by thermal parameters, such as temperature, in addition to mechanical and electromagnetic parameters. (From Hawley's Condensed Chemical Dictionary, 12th ed)
A nodular organ in the ABDOMEN that contains a mixture of ENDOCRINE GLANDS and EXOCRINE GLANDS. The small endocrine portion consists of the ISLETS OF LANGERHANS secreting a number of hormones into the blood stream. The large exocrine portion (EXOCRINE PANCREAS) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the DUODENUM.
Compounds and molecular complexes that consist of very large numbers of atoms and are generally over 500 kDa in size. In biological systems macromolecular substances usually can be visualized using ELECTRON MICROSCOPY and are distinguished from ORGANELLES by the lack of a membrane structure.
Sulfhydryl analog of INOSINE that inhibits nucleoside transport across erythrocyte plasma membranes, and has immunosuppressive properties. It has been used similarly to MERCAPTOPURINE in the treatment of leukemia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p503)
Amidines substituted with a benzene group. Benzamidine and its derivatives are known as peptidase inhibitors.
An exaggerated feeling of physical and emotional well-being not consonant with apparent stimuli or events; usually of psychologic origin, but also seen in organic brain disease and toxic states.
The deliberate attempt to influence attitudes and beliefs for furthering one's cause or damaging an opponent's cause.
Proposed anesthetic with possible anticonvulsant and sedative properties.
A branch of embryology for the study of congenital malformations and developmental abnormalities.
Highly pleasant emotion characterized by outward manifestations of gratification; joy.
Addition of hydrogen to a compound, especially to an unsaturated fat or fatty acid. (From Stedman, 26th ed)
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
A metallic element with the atomic symbol Ir, atomic number 77, and atomic weight 192.22.
The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.
An isomer of 1-PROPANOL. It is a colorless liquid having disinfectant properties. It is used in the manufacture of acetone and its derivatives and as a solvent. Topically, it is used as an antiseptic.
A hard, brittle, grayish-white rare earth metal with an atomic symbol Ru, atomic number 44, and atomic weight 101.07. It is used as a catalyst and hardener for PLATINUM and PALLADIUM.
Acyclic branched or unbranched hydrocarbons having two carbon-carbon double bonds.
All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.
Azoles of one NITROGEN and two double bonds that have aromatic chemical properties.
A publication issued at stated, more or less regular, intervals.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
Lists of persons or organizations, systematically arranged, usually in alphabetic or classed order, giving address, affiliations, etc., for individuals, and giving address, officers, functions, and similar data for organizations. (ALA Glossary of Library and Information Science, 1983)
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.
An enzyme that catalyzes the oxidative deamination of naturally occurring monoamines. It is a flavin-containing enzyme that is localized in mitochondrial membranes, whether in nerve terminals, the liver, or other organs. Monoamine oxidase is important in regulating the metabolic degradation of catecholamines and serotonin in neural or target tissues. Hepatic monoamine oxidase has a crucial defensive role in inactivating circulating monoamines or those, such as tyramine, that originate in the gut and are absorbed into the portal circulation. (From Goodman and Gilman's, The Pharmacological Basis of Therapeutics, 8th ed, p415) EC 1.4.3.4.
A group of enzymes including those oxidizing primary monoamines, diamines, and histamine. They are copper proteins, and, as their action depends on a carbonyl group, they are sensitive to inhibition by semicarbazide.
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).

Long-term effects of N-2-chlorethyl-N-ethyl-2-bromobenzylamine hydrochloride on noradrenergic neurones in the rat brain and heart. (1/702)

1 N-2-Chlorethyl-N-ethyl-2-bromobenzylamine hydrochloride (DSP 4) 50 mg/kg intraperitoneally, produced a long-term decrease in the capacity of brain homogenates to accumulate noradrenaline with significant effect 8 months after the injection. It had no effect on the noradrenaline uptake in homogenates from the striatum (dopamine neurones) and on the uptake of 5-hydroxytryptamine (5-HT) in various brain regions. 2 In vitro DSP 4 inhibited the noradrenaline uptake in a cortical homogenate with an IC50 value of 2 muM but was more than ten times less active on the dopamine uptake in a striatal homogenate and the 5-HT uptake in a cortical homogenate. 3 DSP 4 (50 mg/kg i.p.) inhibited the uptake of noradrenaline in the rat heart atrium in vitro but this action was terminated within 2 weeks. 4 DSP 4 (50 mg/kg i.p.) cuased a decrease in the dopamine-beta-hydroxylase (DBH) activity in the rat brain and heart. The onset of this effect was slow; in heart a lag period of 2-4 days was noted. In brain the DBH-activity in cerebral cortex was much more decreased than that in hypothalamus which was only slightly affected. A significant effect was still found 8 months after the injection. The noradrenaline concentration in the brain was greatly decreased for at least two weeks, whereas noradrenaline in heart was only temporarily reduced. 5 The long-term effects of DSP 4 on the noradrenaline accumulation, the DBH activity and noradrenaline concentration in the rat brain were antagonized by desipramine (10 mg/kg i.p.). 6 It is suggested that DSP 4 primarily attacks the membranal noradrenaline uptake sites forming a covalent bond and that the nerve terminals, as a result of this binding, degenerate.  (+info)

Biochemical and electrophysiological studies on the mechanism of action of PNU-151774E, a novel antiepileptic compound. (2/702)

PNU-151774E [(S)-(+)-2-(4-(3-fluorobenzyloxy)benzylamino)propanamide methanesulfonate], a new anticonvulsant that displays a wide therapeutic window, has a potency comparable or superior to that of most classic anticonvulsants. PNU-151774E is chemically unrelated to current antiepileptics. In animal seizure models it possesses a broad spectrum of action. In the present study, the action mechanism of PNU-151774E has been investigated using electrophysiological and biochemical assays. Binding studies performed with rat brain membranes show that PNU-151774E has high affinity for binding site 2 of the sodium channel receptor, which is greater than that of phenytoin or lamotrigine (IC50, 8 microM versus 47 and 185 microM, respectively). PNU-151774E reduces sustained repetitive firing in a use-dependent manner without modifying the first action potential in hippocampal cultured neurons. In the same preparation PNU-151774E inhibits tetrodotoxin-sensitive fast sodium currents and high voltage-activated calcium currents under voltage-clamp conditions. These electrophysiological activities of PNU-151774E correlate with its ability to inhibit veratrine and KCl-induced glutamate release in rat hippocampal slices (IC50, 56.4 and 185.5 microM, respectively) and calcium inward currents in mouse cortical neurons. On the other hand, PNU-151774E does not affect whole-cell gamma-aminobutryic acid- and glutamate-induced currents in cultured mouse cortical neurons. These results suggest that PNU-151774E exerts its anticonvulsant activity, at least in part, through inhibition of sodium and calcium channels, stabilizing neuronal membrane excitability and inhibiting transmitter release. The possible relevance of these pharmacological properties to its antiepileptic potential is discussed.  (+info)

Calcium/calmodulin-dependent phosphorylation and activation of human Cdc25-C at the G2/M phase transition in HeLa cells. (3/702)

The human tyrosine phosphatase (p54(cdc25-c)) is activated by phosphorylation at mitosis entry. The phosphorylated p54(cdc25-c) in turn activates the p34-cyclin B protein kinase and triggers mitosis. Although the active p34-cyclin B protein kinase can itself phosphorylate and activate p54(cdc25-c), we have investigated the possibility that other kinases may initially trigger the phosphorylation and activation of p54(cdc25-c). We have examined the effects of the calcium/calmodulin-dependent protein kinase (CaM kinase II) on p54(cdc25-c). Our in vitro experiments show that CaM kinase II can phosphorylate p54(cdc25-c) and increase its phosphatase activity by 2.5-3-fold. Treatment of a synchronous population of HeLa cells with KN-93 (a water-soluble inhibitor of CaM kinase II) or the microinjection of AC3-I (a specific peptide inhibitor of CaM kinase II) results in a cell cycle block in G2 phase. In the KN-93-arrested cells, p54(cdc25-c) is not phosphorylated, p34(cdc2) remains tyrosine phosphorylated, and there is no increase in histone H1 kinase activity. Our data suggest that a calcium-calmodulin-dependent step may be involved in the initial activation of p54(cdc25-c).  (+info)

Novel regulation of the A-type K+ current in murine proximal colon by calcium-calmodulin-dependent protein kinase II. (4/702)

1. The kinetics of inactivation of delayed rectifier K+ current in murine colonic myocytes differed in amphotericin-permeabilized patch and conventional patch clamp. The difference was accounted for by Ca2+ buffering. 2. Calcium-calmodulin-dependent protein kinase II (CaMKII) inhibitors increased the rate of inactivation and slowed recovery from inactivation of the outward current. This was seen in single steps and in the envelope of the current tails. The effect was largely on the TEA-insensitive component of current. 3. Dialysis of myocytes with autothiophosphorylated CaMKII slowed inactivation. This effect was reversed by addition of CaMKII inhibitor. 4. Antibodies revealed CaMKII-like immunoreactivity in murine colonic myocytes and other cells. Immunoblots identified a small protein with CaMKII-like immunoreactivity in homogenates of colonic muscle. 5. We conclude that CaMKII regulates delayed rectifier K+ currents in murine colonic myocytes. The changes in the delayed rectifier current may participate in the Ca2+-dependent regulation of gastrointestinal motility.  (+info)

Enhanced amphetamine- and K+-mediated dopamine release in rat striatum after repeated amphetamine: differential requirements for Ca2+- and calmodulin-dependent phosphorylation and synaptic vesicles. (5/702)

After cessation of repeated, intermittent amphetamine, we detected an emergent Ca2+-dependent component of amphetamine-induced dopamine release and an increase in calmodulin and Ca2+- and calmodulin-dependent protein kinase activity in rat striatum. This study examined the involvement of calmodulin-dependent protein kinase II (CaM kinase II) and synaptic vesicles in the enhanced Ca2+-dependent dopamine release in response to amphetamine or K+ in rat striatum. Rats were pretreated for 5 d with 2.5 mg/kg amphetamine or saline and withdrawn from drug for 10 d. The selective CaM kinase II inhibitor KN-93 (1 microM), but not the inactive analog KN-92, attenuated the Ca2+-dependent amphetamine-mediated dopamine release from amphetamine-pretreated rats but had no effect in saline-pretreated controls. [3H]Dopamine uptake was unaltered by repeated amphetamine or KN-93 and was Ca2+ independent. Striatal dopamine release stimulated by 50 mM KCl was enhanced twofold after repeated amphetamine compared with that in saline controls but was unaffected by KN-93. To examine the requirement for dopaminergic vesicles in the Ca2+-dependent dopamine release, we administered reserpine to saline- and amphetamine-pretreated rats 1 d before killing. Reserpine pretreatment did not affect amphetamine-mediated dopamine release from either pretreatment group but completely ablated K+-mediated dopamine release. Reserpine did not disrupt the ability of 1 microM KN-93 to block the Ca2+-dependent amphetamine-mediated dopamine release from amphetamine-pretreated rats. The results indicate that the enhanced dopamine release elicited by amphetamine from chronically treated rats is dependent on Ca2+- and calmodulin-dependent phosphorylation and is independent of vesicular dopamine storage. On the contrary, the enhanced depolarization-mediated vesicular dopamine release is independent of Ca2+- and calmodulin-dependent phosphorylation.  (+info)

Biochemical and biological effects of KN-93, an inhibitor of calmodulin-dependent protein kinase II, on the initial events of mouse egg activation induced by ethanol. (6/702)

Calmodulin-dependent protein kinase II (CaMKII) is transiently activated in mouse eggs by the increase in calcium that occurs upon activation with ethanol. This study investigated the biological and biochemical effects of KN-93, a reported selective inhibitor of CaMKII, to explore the potential role of this kinase in the initial events of egg activation. Mouse eggs were incubated for 30 min in the presence of different concentrations of KN-93 and induced to activate by 7% ethanol. KN-93 elicited a dose-dependent inhibition of polar body emission that resulted from the failure of the eggs to undergo meiosis resumption and inactivation of maturation-promoting factor (MPF). Furthermore, 15 mumol KN-93 l-1 produced a marked reduction in ethanol-induced loss of cortical granules. In vivo biochemical analysis revealed that 15 mumol KN-93 l-1 was responsible for significant inhibition of ethanol-stimulated CaMKII. The activity of the enzyme remained at a resting value, in spite of the presence of a calcium signal similar to that measured in control activated eggs. The inhibitory effects of KN-93 on the parameters tested in this study could not be mimicked by the inactive analogue KN-92. These results show that in mouse eggs, when ethanol-induced CaMKII activation was prevented, cortical granule exocytosis and meiosis resumption were inhibited. This suggests that CaMKII acts as a switch in the transduction of the calcium signal triggering mammalian egg activation.  (+info)

Treatment of toenail onychomycosis with 2% butenafine and 5% Melaleuca alternifolia (tea tree) oil in cream. (7/702)

The prevalence of onychomycosis, a superficial fungal infection that destroys the entire nail unit, is rising, with no satisfactory cure. The objective of this randomized, double-blind, placebo-controlled study was to examine the clinical efficacy and tolerability of 2% butenafine hydrochloride and 5% Melaleuca alternifolia oil incorporated in a cream to manage toenail onychomycosis in a cohort. Sixty outpatients (39 M, 21 F) aged 18-80 years (mean 29.6) with 6-36 months duration of disease were randomized to two groups (40 and 20), active and placebo. After 16 weeks, 80% of patients using medicated cream were cured, as opposed to none in the placebo group. Four patients in the active treatment group experienced subjective mild inflammation without discontinuing treatment. During follow-up, no relapse occurred in cured patients and no improvement was seen in medication-resistant and placebo participants.  (+info)

Mitogen-activated protein kinase activation by stimulation with thyrotropin-releasing hormone in rat pituitary GH3 cells. (8/702)

We examined whether mitogen-activated protein (MAP) kinase is activated by thyrotropin-releasing hormone (TRH) in GH3 cells, and whether MAP kinase activation is involved in secretion of prolactin from these cells. Protein kinase inhibitors--such as PD098059, calphostin C, and genistein--and removal of extracellular Ca2+ inhibited MAP kinase activation by TRH. A cAMP analogue activated MAP kinase in these cells. Effects of cAMP on MAP kinase activation were inhibited by PD098059. TRH-induced prolactin secretion was not inhibited by levels of PD098059 sufficient to i activation but was inhibited by wortmannin (1 microM) and KN93. Treatment of GH3 cells with either TRH or cAMP significantly inhibited DNA synthesis and induced morphological changes. The effects stimulated by TRH were reversed by PD098059 treatment, but the same effects stimulated by cAMP were not. Treatment of GH3 cells with TRH for 48 h significantly increased the prolactin content in GH3 cells and decreased growth hormone content. The increase in prolactin was completely abolished by PD098059, but the decrease in growth hormone was not. These results suggest that TRH-induced MAP kinase activation is involved in prolactin synthesis and differentiation of GH3 cells, but not in prolactin secretion.  (+info)

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The substance appears to have a slight toxicity in higher doses, with effects such as liver and intestinal disorders at high exposure in test animals (just below LD50 level).[citation needed] Some reproductive disorders and decreasing weaning weight have been observed, also at high exposure. Effects on humans from use as a drug include nausea, vomiting, loss of appetite, diarrhea, dizziness, drowsiness, or headache; very rarely also ringing in the ears, vision changes, stomach pain, yellowing eyes and skin, dark urine, fever, fatigue, increased thirst and change in the amount of urine occur.[citation needed] Carcinogenic effects have been shown at higher doses.[11] ...
A polyene is a molecule with multiple conjugated double bonds. A polyene antifungal is a macrocyclic polyene with a heavily hydroxylated region on the ring opposite the conjugated system. This makes polyene antifungals amphiphilic. The polyene antimycotics bind with sterols in the fungal cell membrane, principally ergosterol. This changes the transition temperature (Tg) of the cell membrane, thereby placing the membrane in a less fluid, more crystalline state. (In ordinary circumstances membrane sterols increase the packing of the phospholipid bilayer making the plasma membrane more dense.) As a result, the cell's contents including monovalent ions (K+, Na+, H+, and Cl−), small organic molecules leak and this is regarded one of the primary ways cell dies.[1] Animal cells contain cholesterol instead of ergosterol and so they are much less susceptible. However, at therapeutic doses, some amphotericin B may bind to animal membrane cholesterol, increasing the risk of human toxicity. Amphotericin B ...
It is commonly available without a prescription in various dosage forms, such as a topical cream, ointment, or vaginal suppository. It is also available as an oral troche or throat lozenge as a prescription only. Topically, clotrimazole is used for vulvovaginal candidiasis (yeast infection) or yeast infections of the skin. For vulvovaginal candidiasis (yeast infection), clotrimazole tablets and creams are inserted into the vagina. Topical clotrimazole is usually not effective in treatment of fungal infections of the scalp or nails.[citation needed] When using over-the-counter drug clotrimazole products, use should be discontinued if condition does not improve after treatment for 2 weeks for jock itch or after 4 weeks for athlete's foot or ringworm.[6] Throat lozenge preparations are used for oropharyngeal candidiasis (oral thrush) or prevention of oral thrush in people with neutropenia.[6] Clotrimazole is usually used 5 times daily for 14 days for oral thrush, twice daily for 2 to 8 weeks for ...
InChI=1S/C58H73N7O17/c1-5-6-7-24-82-40-22-18-35(19-23-40)33-10-8-32(9-11-33)34-12-14-37(15-13-34)51(74)59-41-26-43(70)54(77)63-56(79)47-48(71)29(2)27-65(47)58(81)45(31(4)67)61-55(78)46(50(73)49(72)36-16-20-38(68)21-17-36)62-53(76)42-25-39(69)28-64(42)57(80)44(30(3)66)60-52(41)75/h8-23,29-31,39,41-50,54,66-73,77H,5-7,24-28H2,1-4H3,(H,59,74)(H,60,75)(H,61,78)(H,62,76)(H,63,79)/t29-,30+,31+,39+,41-,42?,43+,44?,45?,46?,47?,48-,49+,50+,54+/m0/s1 ...
... , also known as selenium sulfide, is a medication used to treat pityriasis versicolor, seborrhoeic dermatitis, and dandruff.[1] It is applied to the affected area as a lotion or shampoo.[2] Dandruff frequently returns if treatment is stopped.[3] Side effects include hair loss, irritation of the skin, weakness, and feeling tired.[1] Use is not recommended in children less than 2-5 years old.[3][1] Use in pregnancy or breastfeeding has not been studied.[4] Selenium disulfide is an inorganic compound with the chemical formula SeS2.[5] Selenium disulfide was approved for medical use in the United States at least as early as 1951.[3] It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.[6] Selenium disulfide is available as a generic medication and over the counter.[2] In the United States a month of treatment costs less than 25 USD.[2] In the United Kingdom 100 ml of 2.5% shampoo costs the NHS about ...
... (trade names Oxistat in the US, Oxizole in Canada) is an antifungal medication typically administered in a cream or lotion to treat skin infections, such as athlete's foot, jock itch and ringworm. It can also be prescribed to treat the skin rash known as tinea versicolor, caused by systemic yeast overgrowth (Candida spp.). ...
... has been used for decades in the food industry as a hurdle to fungal outgrowth in dairy products and other foods. Potential advantages for the usage of natamycin might include the replacement of traditional chemical preservatives, a neutral flavor impact, and less dependence on pH for efficacy, as is common with chemical preservatives. It can be applied in a variety of ways: as an aqueous suspension (such as mixed into a brine) sprayed on the product or into which the product is dipped, or in powdered form (along with an anticaking agent such as cellulose) sprinkled on or mixed into the product. While not currently approved for use on meats in the United States, some countries allow natamycin to be applied to the surface of dry and fermented sausages to prevent mold growth on the casing. Also, natamycin is approved for various dairy applications in the United States. More specifically, natamycin is commonly used in products such as cream cheeses, cottage cheese, sour cream, yogurt, ...
Benzylamine[147] Phenylalanine with valine, leucine or isoleucine[148] Capsaicin, dihydrocapsaicin, nordihydrocapsaicin, ...
Lazareva, Anna; Daugulis, Olafs (2006). "Direct Palladium-Catalyzed Ortho-Arylation of Benzylamines". Organic Letters. 8 (23): ... of benzylamines and N-methylbenzylamines. The reaction is palladium-catalyzed and requires a slight excess of silver acetate. ...
"N,N-dimethyl benzyl amine". The Good Scents Company. Retrieved 1 November 2020. CS1 maint: discouraged parameter (link) Icke, R ... N,N-Dimethylbenzylamine can be synthesized by the Eschweiler-Clarke reaction of benzylamine It undergoes directed ortho ...
This protein preferentially degrades benzylamine and phenethylamine. Similarly to monoamine oxidase A (MAOA), it also degrades ...
DOM has traditionally been applied to tertiary anilines and benzyl amines. The method has also been applied to the synthesis of ... enantiopure benzyl amines in scheme 3, which involves ortho-lithiation of tert-butyl phenyl sulfoxide. On approach to the ...
They can be prepared by N-alkylation of benzyl amines with haloacetophenones. Naturally occurring tetrahydroisoquinolines ...
Kroutil, J.; Trnka, T.; Cerny, M. (2004). "Improved procedure for the selective N-debenzylation of benzylamines by diisopropyl ...
Another important class of compounds that can be derived from boronate esters is α-substituted benzylamines, some of which are ... Reaction of the trialkylborane with hydroxylamine-O-sulfonic acid produces primary benzylamines. Secondary amines can also be ...
ALPHA (alpha-ethyl-3,4-methylenedioxybenzylamine) is a lesser-known psychedelic drug and a substituted benzylamine. It is also ... the benzylamine analog of 3,4-methylenedioxyamphetamine (MDA). ALPHA was first synthesized by Alexander Shulgin. In his book ...
Buffoni F, Blaschko H (1964). "Benzylamine oxidase and histaminase: purification and crystallization of an enzyme from pig ...
Like benzylamine, it is highly basic and forms stable ammonium salts and imines. This compound may be prepared by the reductive ...
An example is the reaction of cyclopentadiene with benzylamine to an aza norbornene. In the enantioselective Diels-Alder (DA) ...
Benzylamine[103] Phenylalanine with valine, leucine or isoleucine[104] Capsaicin, dihydrocapsaicin, nordihydrocapsaicin, ...
A second hydrogenation in the presence of benzylamine leads to the reductive amination product (8). Michael addition of the ...
... but benzylamine. In 1891, a colleague of Leuckart at the University of Göttingen, Otto Wallach, performed further reactions ...
... can be synthesized from a benzylamine derivative and a pyrimidine derivative: "Stendra FDA Approval History". Drugs. ...
Cyclometallation with a Substituted Benzylamine, and Insertion of an Alkyne". J. Chem. Educ. 84 (6): 1014. Bibcode:2007JChEd.. ...
... T molecule consists of a benzylamine and a benzothiazole ring connected through a carbon-carbon bond. These two ...
... , sold under the brand names Lotrimin Ultra, Mentax, and Butop (India), is a synthetic benzylamine antifungal. It is ...
Initially, addition to the aromatic ring results in an intermediate at the oxidation state of a benzylamine. An intramolecular ...
Palladium(II) and platinum(II) have long been known to ortho-metalate aromatic ligands such as azobenzene, benzylamines, and 2- ...
Depending on the hydrolysis conditions, the hexamine unit might instead break apart, leaving a benzyl amine (the Delépine ...
First, benzylamine (1) is condensed with glyoxal (2) under acidic and dehydrating conditions to yield the first intermediate ...
... benzylamine, 1utj, Benzylamine (en); بنزیل‌امین, بنزیل آمین, بنزیل امین (fa); Benzylamin (cs); 1-fenylometyloamina (pl) ... Media in category "Benzylamine". The following 13 files are in this category, out of 13 total. ... Benzilammina (it); Benzylamine (fr); بنزیل‌آمین (azb); Benzylamin (de); Benzilamin (sr-el); Бензиламин (sr-ec); بنزیل‌آمین (fa ... benzylamine (en); Benzilamino (eo); Βενζυλαμίνη (el); பென்சைலமின் (ta) compuesto químico (es); konposatu kimiko (eu); compuestu ...
Benzylamine exhibits modest oral toxicity in rats with LD50 of 1130 mg/kg. It is readily biodegraded. "Benzylamine". Sigma- ... Benzylamine is degraded biologically by the action of the monoamine oxidase B enzyme, resulting in benzaldehyde. Benzylamine is ... An example is the reaction of cyclopentadiene with benzylamine to form an aza-norbornene. Benzylamine is used in the industrial ... The hydrochloride salt of benzylamine, C6H5CH2NH3Cl or C6H5CH2NH2·HCl, is prepared by reacting benzylamine with hydrochloric ...
Benzylamine ReagentPlus(R), 99%; CAS No.: 100-46-9; Synonyms: alpha-Aminotoluene; Linear Formula: C6H5CH2NH2; Empirical Formula ... Benzylamine undergoes oxidative deamination reaction catalyzed by benzylamine oxidase and monoamine oxidase type B. ... Benzylamine was used in modification of alkanethiol monolayers via amide and ester formation reactions for attachment onto ...
Benzylamine was administered by oral-gavage to male rats for 28 days and to female rats for 14 days prior to pairing, through ... Under the conditions of this study, the test item Benzylamine produced gastric lesions in both sexes of all test item treatment ... Developmental Toxicity Screening Test under relevant test conditions of the test substance Benzylamine, classification is not ...
Estimates by the MCI method and the log-Kow method of KOCWIN v2.00 (EPISuite v4.11; BASF SE 2015) calculated for Benzylamine ... For the assessment of Benzylamine (Q)SAR results were used for the estimation of the adsorption potential. The criteria listed ...
Benzylamine. PDB Entries. 1n6x / 1n6y / 1utj / 1utn / 2bza / 2eus / 2hxc / 3nzj / 3nzw / 3nzx … ... Benzylamines / Aralkylamines / Organopnictogen compounds / Monoalkylamines / Hydrocarbon derivatives. Substituents. ... Phenylmethylamine / Benzylamine / Aralkylamine / Organic nitrogen compound / Organopnictogen compound / Hydrocarbon derivative ... Benzylamine. Accession Number. DB02464 (EXPT00400) Type. Small Molecule. Groups. Experimental. Description. Not Available. ...
... benzylamine AldrichCPR; Linear Formula: C8H7F4N; find Sigma-Aldrich-CDS000899 MSDS, related peer-reviewed papers, technical ... benzylamine AldrichCPR * Empirical Formula (Hill Notation) C8H7F4N ...
Cyclopropyl-(2-fluoro-benzyl)-amine | C10H12FN | CID 1080490 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Benzylamines: Toluenes in which one hydrogen of the methyl group is substituted by an amino group. Permitted are any ... Benzylamines (Phenylmethylamine). Subscribe to New Research on Benzylamines Toluenes in which one hydrogen of the methyl group ... N,N-dilactitol-3,5-bis(trifluoromethyl)benzylamine: 1. *N-(3-(4-morpholino)propyl)-N-methyl-2-hydroxy-5-iodo-3- ... N,N-dilactitol-3,5-bis(trifluoromethyl)benzylamine: 1. *N-(3-(4-morpholino)propyl)-N-methyl-2-hydroxy-5-iodo-3- ...
Topical benzylamines. Class Summary. Topical benzylamines are sometimes classified as a subset of allylamines. They are useful ... Topical benzylamines have been shown to be effective in some patients with interdigital tinea pedis with only 1 week of ... for treating patients with refractory tinea pedis (eg, chronic hyperkeratotic). Topical benzylamines have been shown to be ...
... relative free energy of binding of trypsin to benzamidine and benzylamine. ...
Charles K. Bradsher,; Richard S. Kittila. Chlorination of 1,3-bis-(Trifluoromethyl)-benzenes. J. Am. Chem. Soc. 1948, 70 (4), 1318-1320.. Steven J. Taylor,; Fariba Soleymanzadeh,; Anne B. Eldrup,; Neil A. Farrow,; Ingo Muegge,; Alison Kukulka,; Alisa K. Kabcenell,; Stephane De Lombaert. Design and synthesis of substituted nicotinamides as inhibitors of soluble epoxide hydrolase. Bioorganic & Medicinal Chemistry Letters. 2009, 19(20),5864-5868.. ...
Indicaciones de precaución: P260u-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a Do not breathe dusts or mists. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations. ...
1-2-1h-imidazol-1-yl phenyl methanamine, 2-imidazol-1-yl-benzylamine, 2-1h-imidazol-1-yl phenyl methanamine, 2-1h-imidazol-1-yl ... 1-2-1h-imidazol-1-yl phenyl methanamine, 2-imidazol-1-yl-benzylamine, 2-1h-imidazol-1-yl phenyl methanamine, 2-1h-imidazol-1-yl ... benzylamine, 2-imidazol-1-yl phenyl methanamine, benzenemethanamine, 2-1h-imidazol-1-yl, 2-imidazolylphenyl methylamine, 2-1h- ... benzylamine, 2-imidazol-1-yl phenyl methanamine, benzenemethanamine, 2-1h-imidazol-1-yl, 2-imidazolylphenyl methylamine, 2-1h- ...
... and chemoselective Csp3-H arylation of benzylamines mediated by synergy of single electron transfer (SET) and hydrogen atom ... We present a highly regio- and chemoselective Csp3-H arylation of benzylamines mediated by synergy of single electron transfer ... Regio- and chemoselective Csp3-H arylation of benzylamines by single electron transfer/hydrogen atom transfer synergistic ... Regio- and chemoselective Csp3-H arylation of benzylamines by single electron transfer/hydrogen atom transfer synergistic ...
Cyclopentyl-(2-fluoro-benzyl)-amine | C12H16FN | CID 1080487 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
This report studies Benzylamine in Global market, especially in North... ... 106 Pages Report] Check for Discount on Global Benzylamine Market Professional Survey Report 2018 report by QYResearch Group. ... 5.2 China Benzylamine Market Analysis. 5.2.1 China Benzylamine Market Overview. 5.2.2 China 2012-2017E Benzylamine Local Supply ... 5.5 Japan Benzylamine Market Analysis. 5.5.1 Japan Benzylamine Market Overview. 5.5.2 Japan 2012-2017E Benzylamine Local Supply ...
In the presence of Ba2+ (1 mM) or in Ca(2+)-free perfusions, the benzylamine-induced net K+ efflux was diminished by 60-70% or ... In this work, we therefore investigated whether benzylamine on its own was able to induce both in vivo and in vitro insulin- ... Among monoamines tested, three compounds namely phenylethylamine, tyramine and benzylamine were shown to be good substrates for ... Relation of blood serotonin and benzylamine oxidase to clinical symptoms and prognosis in Parkinsons disease [12]. ...
Practical synthesis of enantiopure benzylamines by catalytic hydrogenation or transfer hydrogenation reactions in isopropanol ... Practical synthesis of enantiopure benzylamines by catalytic hydrogenation or transfer hydrogenation reactions in isopropanol ...
Benzylamine was metabolized to only a small extent by rat liver subcellular fractions. In contrast, it was extensively ... The in vivo and in vitro disposition of benzylamine was investigated in rats. ... 0/Benzylamines; 0/Glutamates; 0/Oximes; 100-46-9/benzylamine; 70-18-8/Glutathione; 9035-51-2/Cytochrome P-450 Enzyme System ... The in vivo and in vitro disposition of benzylamine was investigated in rats. Benzylamine was metabolized to only a small ...
1-4-1,2,3-thiadiazol-4-yl phenyl methanamine hydrochloride, 4-1,2,3-thiadiazol-4-yl benzylamine hydrochloride, 4-1,2,3- ... 1-4-1,2,3-thiadiazol-4-yl phenyl methanamine hydrochloride, 4-1,2,3-thiadiazol-4-yl benzylamine hydrochloride, 4-1,2,3- ... 1-4-1,2,3-thiadiazol-4-yl phenyl methanamine hydrochloride, 4-1,2,3-thiadiazol-4-yl benzylamine hydrochloride, 4-1,2,3- ...
You can also browse global suppliers,vendor,prices,Price,manufacturers of 2-(TRIFLUOROMETHYL)BENZYLAMINE(3048-01-9). At last,2 ... TRIFLUOROMETHYL)BENZYLAMINE(3048-01-9) safety, risk, hazard and MSDS, CAS,cas number,Use,cas no may also be you need. ... BENZYLAMINE(3048-01-9) information like chemical properties,Structure,melting point,boiling point,density,molecular formula, ... 2-(TRIFLUOROMETHYL)BENZYLAMINE Spectrum. 2-(TRIFLUOROMETHYL)BENZYLAMINE(3048-01-9) 1H NMR2-(TRIFLUOROMETHYL)BENZYLAMINE(3048-01 ...
... Dong Wan Kim,a Tae Ho Kim,a,* Jineun Kim,a ...
Isolation of an N-alkylated Benzylamine Derivative from Pseudomonas putida BTP1 as Elicitor of Induced Systemic Resistance in ... The specific involvement of the N-alkylated benzylamine derivative (NABD) in ISR elicitation was first evidenced by testing the ... Mass spectrometry analyses performed on both the bacterial product and synthetic analogues revealed a polyalkylated benzylamine ...
DNA Binding and Antioxidant Studies of Benzylamine Supported Pd (II) Complex Abstract. ... A benzylamine supported palladium (II) complex has been synthesized and characterized using different spectroscopic techniques ... Synthesis, Characterization, Anticancer, DNA Binding and Antioxidant Studies of Benzylamine Supported Pd (II) Complex. Nitin ... DNA Binding and Antioxidant Studies of Benzylamine Supported Pd (II) Complex. Cancer Med Anticancer Drug 1:101. doi:10.4172/ ...
... benzylamine) monomers: One-pot preparation and application in dendrimer scaffolds for removing pyrene from aqueous environments ... benzylamine) monomers: One-pot preparation and application in dendrimer scaffolds for removing pyrene from aqueous environments ... Bis(benzylamine) monomers: One-pot preparation and application in dendrimer scaffolds for removing pyrene from aqueous ... This result was in contrast to comparable systems [14], which required heat to form benzyl amine products exclusively. A ...
... , Priya ... Benzylamine derivatives have recently been demonstrated interesting potential as the treatment for chronic obstructive ... kNN-MFA-guided 3D-QSAR on Some PDE4 Inhibitors of Benzylamine derivatives For Chronic Obstructive Pulmonary Disease. ... Figure 1: Molecular alignment of benzylamine derivatives. A. Template for molecular alignment and B. template-based alignment ...
N-METHYL-N-[3-(PYRIDIN-2-YLOXY)BENZYL]AMINE 化学特性,用途語,生産方法. N-METHYL-N-[3-(PYRIDIN-2-YLOXY)BENZYL]AMINE 上流と下流の製品情報. 原材料. 準備製品. ... N-METHYL-N-[3-(PYRIDIN-2-YLOXY)BENZYL]AMINE. 英語别名:. N-METHYL-N-[3-(PYRIDIN-2-YLOXY)BENZYL]AMINE. CBNumber:. CB2840932. 化学式:. ... N-METHYL-N-[3-(PYRIDIN-2-YLOXY)BENZYL]AMINE 価格 メーカー. 製品番号. 製品説明. CAS番号. 包装. 価格. 更新時間. 購入. ... N-METHYL-N-[3
We report a photocatalytic oxidation procedure that can be used to convert benzylamines into their corresponding aldehydes ...
The invention relates to novel basic-substituted benzylamine analogues as inhibitors of coagulation factor Xa, their ... Benzylamine derivatives and their use as thrombin inhibitors DE10102878A1 (en) 2001-01-23. 2002-08-01. Haemosys Gmbh. Oligo- or ... Basic substituted benzylamine analogs as coagulation factor Xa inhibitors, their preparation and use Info. Publication number. ... Base-substituted benzylamine analogs for use as coagulation factor xa inhibitors, the production and use thereof ...
  • The formation of the S-benzyl-L-glutathione conjugate showed that a net displacement of amine from benzylamine had taken place with a subsequent addition of glutathione at the benzylic position. (biomedsearch.com)
  • 6. The composition of claim 1, wherein the amine or amine derivative is selected from monoethanolamine, ethylene diamine, benzylamine, glyoxal, and diglycol-amine. (freepatentsonline.com)
  • The relative free energies of binding of trypsin to two amine inhibitors, benzamidine (BZD) and benzylamine (BZA), were calculated using non-Boltzmann thermodynamic integration (NBTI). (proteopedia.org)
  • He also obtained it, together with dibenzyl- amine and tribenzylamine, by heating benzyl chloride with alcoholic ammonia, 2 and described the separation of these bases and the properties of benzylamine. (ebooksread.com)
  • In the pesticide industry, benzylamine is used for the synthesis of cell active penetrant. (jngreatchem.com)
  • We show that 4 catalyzes the aerobic oxidative deamination of benzylamine , though turnover eventually ceases on account of oxidation of the dihydrobenzoxazole tautomer of the "product Schiff base" to form a benzoxazole, a reaction that may be physiologically relevant [16]. (openwetware.org)
  • The oxidative deamination of benzylamine yielding the benzaldehyde was demonstrated to be a precursor to the hippuric acid metabolite and S-benzyl-L-glutathione. (biomedsearch.com)
  • The products of the benzylamine oxidative coupling are imine and ammonia. (fu-berlin.de)
  • The hydrochloride salt of benzylamine, C6H5CH2NH3Cl or C6H5CH2NH2·HCl, is prepared by reacting benzylamine with hydrochloric acid, and can be used in treating motion sickness. (wikipedia.org)
  • NASA astronaut John Glenn was issued with benzylamine hydrochloride for this purpose for the Mercury-Atlas 6 mission. (wikipedia.org)
  • Benzylamine is degraded biologically by the action of the monoamine oxidase B enzyme, resulting in benzaldehyde. (wikipedia.org)
  • Relation of blood serotonin and benzylamine oxidase to clinical symptoms and prognosis in Parkinson's disease [12]. (openwetware.org)
  • The invention relates to novel basic-substituted benzylamine analogues as inhibitors of coagulation factor Xa, their preparation and use for the therapy and prophylaxis of cardiovascular diseases and thromboembolic events. (google.com)
  • Among monoamines tested, three compounds namely phenylethylamine, tyramine and benzylamine were shown to be good substrates for superoxide-generating reactions by the Cu-bound helical peptide.Conclusions: Possible roles for these reactions in development of prion disease were suggested [14]. (openwetware.org)
  • MAOB preferentially degrades benzylamine and phenylethylamine. (uniprot.org)
  • and MAO-B: phenylethylamine and benzylamine). (aspetjournals.org)
  • Benzylamine is an organic chemical compound with the condensed structural formula C6H5CH2NH2 (sometimes abbreviated as PhCH2NH2 or BnNH2). (wikipedia.org)
  • Benzylamine is used as a masked source of ammonia, since after N-alkylation, the benzyl group can be removed by hydrogenolysis: C6H5CH2NH2 + 2 RBr → C6H5CH2NR2 + 2 HBr C6H5CH2NR2 + H2 → C6H5CH3 + R2NH Typically a base is employed in the first step to absorb the HBr (or related acid for other kinds of alkylating agents). (wikipedia.org)
  • Benzylamine is the chemical compound with the formula C6H5CH2NH2. (hisupplier.com)
  • Other derivatives of benzylamine and its salts have been shown to have anti-emetic properties, including those with the N-(3,4,5-trimethoxybenzoyl)benzylamine moiety. (wikipedia.org)
  • Commercially available motion-sickness agents including cinnarizine and meclizine are derivatives of benzylamine. (wikipedia.org)
  • While visible light-driven α-C-H functionalization of amines has mostly been demonstrated with aniline derivatives and tetrahydroisoquinolines (THIQs), our method is applicable to a variety of primary, secondary and tertiary benzylamines for efficient N -benzylic C-H arylation. (rsc.org)
  • Benzylamine derivatives have recently been demonstrated interesting potential as the treatment for chronic obstructive pulmonary disease via interaction with the PDE4 enzymes. (ijpsonline.com)
  • The focus of the present work was to develop the 3D-QSAR-based k-nearestneighbour molecular field analysis (kNN-MF) studies on benzylamine derivatives. (ijpsonline.com)
  • Benzylamine and PGA were heated in DMSO for 1 to 26 h at temperatures between 110 and 130 °C, producing derivatives of various degrees of benzylamidation as a function of the reaction time and temperature. (elsevier.com)
  • Benzylamine is colorless liquid, which could be used in the industry of pharmaceutical and pesticide. (jngreatchem.com)
  • Benzylamine is a colorless liquid that is miscible with water, ethanol and diethyl ether. (jngreatchem.com)
  • Isoquinoline itself is efficiently prepared using the Pomeranz-Fritsch reaction, but can also be prepared from benzylamine and glyoxal acetal by an analogous approach known as the Schlittler-Müller modification to the Pomeranz-Fritsch reaction. (wikipedia.org)
  • HNIW is prepared by first condensing benzylamine with glyoxal in acetonitrile under acidic and dehydrating conditions. (wikipedia.org)
  • Richard A. Plunkett, Jerry L. Neff, Timothy A. Bemish, 'Process for the production of benzylamine and dibenzylamine. (drugbank.ca)
  • Tyramine or benzylamine was added to the medium in order to obtain 1 mM concentration and to serve as substrates for AO activities, as already stated [29]. (thefreedictionary.com)
  • Mass spectrometry analyses performed on both the bacterial product and synthetic analogues revealed a polyalkylated benzylamine structure, with the quaternary ammonium substituted by methyl, ethyl, and C 13 aliphatic groups responsible for the relative hydrophobicity of the molecule. (apsnet.org)
  • Change to vacuum distillation, steam to dry, add alkali solution, free benzylamine, atmospheric distillation and vacuum distillation to obtain the product. (jngreatchem.com)
  • Moreover, the formation of Benzylamine and 3-Methylamino benzonitrile is due to the hydrogenation of benzonitrile and m-tolunitrile as impurities in the feed, respectively. (thefreedictionary.com)
  • The solubility of these salts was orders of magnitude higher than those reported for the corresponding salts of benzylamine (I). Thermal analysis indicated that the increased solubility was caused by reduced crystal lattice energy, which was most likely due to the reduced number of strong hydrogen bonds of the salt of (II) and (III). (ku.dk)
  • Benzylamine can be produced by several methods, the main industrial route being the reaction of benzyl chloride and ammonia. (wikipedia.org)
  • Benzylamine reacts with acetyl chloride to form N-benzylacetamide, an exemplar of the Schotten-Baumann reaction first described in the 1880s. (wikipedia.org)
  • An example is the reaction of cyclopentadiene with benzylamine to form an aza-norbornene. (wikipedia.org)
  • Partially benzylamidated, amphipathic poly(γ-glutamic acid) (BzPGA) was synthesized from poly(γ-glutamic acid) (PGA) and benzylamine by direct amidation in dimethyl sulfoxide (DMSO). (elsevier.com)
  • To estimate the brain serotonergic condition, we measured the serotonin transporter nondisplaceable binding potential cerebrum-wide using positron emission tomography with [11C]N,N-dimethyl-2-(2-amino-4-cyanophenylthio)benzylamine ([11C] DASB). (nature.com)
  • We present a highly regio- and chemoselective Csp 3 -H arylation of benzylamines mediated by synergy of single electron transfer (SET) and hydrogen atom transfer (HAT) catalysis. (rsc.org)
  • Silver acetate is used to prepare sulfenamides from disulfides and secondary amines: R2NH + AgOAc + (RS)2 → R2NSR + AgSR + HOAc A solution of silver acetate in pyridine absorbs hydrogen, producing metallic silver: 2 CH3CO2Ag + H2 → 2 Ag + 2 CH3CO2H Silver acetate is a reagent for direct ortho-arylation (to install two adjacent substituents on an aromatic ring) of benzylamines and N-methylbenzylamines. (wikipedia.org)
  • Measured by its ability to produce hydrogen peroxide during the oxidation of benzylamine. (rndsystems.com)
  • Derived using a fluorescent standard prepared by incubating 50 µM AUR, 1 unit/mL HRP, 1 mM Benzylamine, and a curve of Hydrogen Peroxide (Sigma, Catalog # H1009) in Assay Buffer. (rndsystems.com)
  • PEA is more common in the urine of predators than herbivores (right) and is structurally similar to another molecule, benzylamine , that triggers no response in rats. (thefreedictionary.com)
  • Bioactivation of benzylamine to reactive intermediates in rodents: formation of glutathione, glutamate, and peptide conjugates. (biomedsearch.com)
  • The presence of various glutathione adducts indicated that benzylamine was metabolized to a number of reactive intermediates. (biomedsearch.com)
  • The reactive diluent was benzylamine (BA 99% from Riedel-de Haen), with an equivalent weight of 53. (thefreedictionary.com)
  • We report a photocatalytic oxidation procedure that can be used to convert benzylamines into their corresponding aldehydes under mild conditions without over-oxidation, using riboflavin tetraacetate as photocatalyst and blue emitting LEDs (440 nm) as light source. (uni-regensburg.de)
  • Topical benzylamines have been shown to be effective in some patients with interdigital tinea pedis with only 1 week of treatment. (medscape.com)
  • T. Yoshida , Glycamine Formation via Reductive Amination of Oligosaccharides with Benzylamine. (elsevier.com)
  • The specific involvement of the N-alkylated benzylamine derivative (NABD) in ISR elicitation was first evidenced by testing the purified compound that mimicked the protective effect afforded by crude supernatant samples. (apsnet.org)
  • In the presence of CO2, potassium poly(heptazine imide) (K-PHI) can be charged by up to 1000 μmol of electrons per gram of the material using benzylamine as an electron donor. (fu-berlin.de)
  • The major metabolite of benzylamine was the hippuric acid formed by glycine conjugation of benzoic acid. (biomedsearch.com)
  • LC/MS analysis of bile and urine obtained from rats dosed with 1:1 equimolar mixture of either d(0):d(7)- or d(0):d(2)-benzylamine showed the presence of several glutathione adducts in addition to the hippuric acid metabolite. (biomedsearch.com)
  • The nine other sachets, Aquino said, contain Isoprophyl Benzylamine , 'a chemical compound used as a precursor or base ingredient in manufacturing drugs. (thefreedictionary.com)
  • In the pharmaceutical industry, benzylamine is a key compound in the active components of synthetic drugs. (jngreatchem.com)
  • In vivo studies performed with stable isotope-labeled benzylamine enabled rapid mass spectrometric identification of metabolites present in rat bile and urine. (biomedsearch.com)
  • The in vivo and in vitro disposition of benzylamine was investigated in rats. (biomedsearch.com)
  • For the assessment of Benzylamine (Q)SAR results were used for the estimation of the adsorption potential. (europa.eu)
  • We will provide you benzylamine with high quality and competitive price. (jngreatchem.com)
  • Alcohol " in which he says " Toluidine, C 7 H 9 N, is generally looked upon as the primary benzylamine. (ebooksread.com)
  • He found that the primary benzylamine, which he had prepared from benzyl cyanate (benzyl isocyanurate), is a strong base resembling ethylamine and amy la- mine in its properties. (ebooksread.com)