A benzyl-indazole having analgesic, antipyretic, and anti-inflammatory effects. It is used to reduce post-surgical and post-traumatic pain and edema and to promote healing. It is also used topically in treatment of RHEUMATIC DISEASES and INFLAMMATION of the mouth and throat.
Oxidases that specifically introduce DIOXYGEN-derived oxygen atoms into a variety of organic molecules.
Solutions for rinsing the mouth, possessing cleansing, germicidal, or palliative properties. (From Boucher's Clinical Dental Terminology, 4th ed)
An INFLAMMATION of the MUCOSA with burning or tingling sensation. It is characterized by atrophy of the squamous EPITHELIUM, vascular damage, inflammatory infiltration, and ulceration. It usually occurs at the mucous lining of the MOUTH, the GASTROINTESTINAL TRACT or the airway due to chemical irritations, CHEMOTHERAPY, or radiation therapy (RADIOTHERAPY).
An iodinated polyvinyl polymer used as topical antiseptic in surgery and for skin and mucous membrane infections, also as aerosol. The iodine may be radiolabeled for research purposes.
A sweet viscous liquid food, produced in the honey sacs of various bees from nectar collected from flowers. The nectar is ripened into honey by inversion of its sucrose sugar into fructose and glucose. It is somewhat acidic and has mild antiseptic properties, being sometimes used in the treatment of burns and lacerations.
INFLAMMATION of the soft tissues of the MOUTH, such as MUCOSA; PALATE; GINGIVA; and LIP.
A basic aluminum complex of sulfated sucrose.
A group of islands in the southwest Pacific. Its capital is Wellington. It was discovered by the Dutch explorer Abel Tasman in 1642 and circumnavigated by Cook in 1769. Colonized in 1840 by the New Zealand Company, it became a British crown colony in 1840 until 1907 when colonial status was terminated. New Zealand is a partly anglicized form of the original Dutch name Nieuw Zeeland, new sea land, possibly with reference to the Dutch province of Zeeland. (From Webster's New Geographical Dictionary, 1988, p842 & Room, Brewer's Dictionary of Names, 1992, p378)
The privacy of information and its protection against unauthorized disclosure.
A mechanism of communication within a system in that the input signal generates an output response which returns to influence the continued activity or productivity of that system.
The state of being free from intrusion or disturbance in one's private life or affairs. (Random House Unabridged Dictionary, 2d ed, 1993)
Protective measures against unauthorized access to or interference with computer operating systems, telecommunications, or data structures, especially the modification, deletion, destruction, or release of data in computers. It includes methods of forestalling interference by computer viruses or so-called computer hackers aiming to compromise stored data.
Duties that are based in ETHICS, rather than in law.
The process of assigning duties to a subordinate with lesser qualifications.

Antifungal activity of local anesthetics against Candida species. (1/17)

OBJECTIVE: To evaluate the activity of benzydamine, lidocaine, and bupivacaine, three drugs with local anesthetic activity, against Candida albicans and non-albicans strains and to clarify their mechanism of activity. METHODS: The minimal inhibitory concentration (MIC) was determined for 20 Candida strains (18 clinical isolates and two American Type Culture Collection strains). The fungistatic activity was studied with the fluorescent probe FUN-1 and observation under epifluorescence microscopy and flow cytometry. The fungicidal activity of the three drugs was assayed by viability counts. Membrane alterations induced in the yeast cells were evaluated by staining with propidium iodide, by quantitation of intracellular K+ leakage and by transmission electron microscopy of intact yeast cells and prepared spheroplasts. RESULTS: The MIC ranged from 12.5-50.0 microg/mL, 5.0-40.0 mg/mL, and 2.5-10.0 mg/mL for benzydamine, lidocaine, and bupivacaine, respectively. The inhibitory activity of these concentrations could be detected with the fluorescent probe FUN-1 after incubation for 60 minutes. A very fast fungicidal activity was shown by 0.2, 50, and 30 mg/mL of benzydamine, lidocaine, and bupivacaine, respectively. CONCLUSIONS: At lower concentrations, the tested drugs have a fungistatic activity, due to yeast metabolic impairment, while at higher concentrations they are fungicidal, due to direct damage to the cytoplasmic membrane.  (+info)

In vitro evaluation of potential in vivo probes for human flavin-containing monooxygenase (FMO): metabolism of benzydamine and caffeine by FMO and P450 isoforms. (2/17)

AIMS To determine the FMO and P450 isoform selectivity for metabolism of benzydamine and caffeine, two potential in vivo probes for human FMO. METHODS Metabolic incubations were conducted at physiological pH using substrate concentrations of 0.01-10 mM with either recombinant human FMOs, P450s or human liver microsomes serving as the enzyme source. Products of caffeine and benzydamine metabolism were analysed by reversed-phase h.p.l.c. with u.v. and fluorescence detection. RESULTS CYP1A2, but none of the human FMOs, catalysed metabolism of caffeine. In contrast, benzydamine was a substrate for human FMO1, FMO3, FMO4 and FMO5. Apparent Km values for benzydamine N-oxygenation were 60 +/- 8 microM, 80 +/- 8 microM, > 3 mM and > 2 mM, for FMO1, FMO3, FMO4 and FMO5, respectively. The corresponding Vmax values were 46 +/- 2 min-1, 36 +/- 2 min-1, < 75 min-1 and < 1 min-1. Small quantities of benzydamine N-oxide were also formed by CYPs 1A1, 1A2, 2C19, 2D6 and 3A4. CONCLUSIONS: FMO1 and FMO3 catalyse benzydamine N-oxygenation with the highest efficiency. However, it is likely that the metabolic capacity of hepatic FMO3 is a much greater contributor to plasma levels of the N-oxide metabolite in vivo than is extrahepatic FMO1. Therefore, benzydamine, but not caffeine, is a potential in vivo probe for human FMO3.  (+info)

Benzydamine N-oxidation as an index reaction reflecting FMO activity in human liver microsomes and impact of FMO3 polymorphisms on enzyme activity. (3/17)

AIMS: The role of flavin containing monooxygenases (FMO) on the disposition of many drugs has been insufficiently explored. In vitro and in vivo tests are required to study FMO activity in humans. Benzydamine (BZD) N-oxidation was evaluated as an index reaction for FMO as was the impact of genetic polymorphisms of FMO3 on activity. METHODS: BZD was incubated with human liver microsomes (HLM) and recombinant enzymes. Human liver samples were genotyped using PCR-RFLP. RESULTS: BZD N-oxide formation rates in HLM followed Michaelis-Menten kinetics (mean Km = 64.0 microM, mean Vmax = 6.9 nmol mg-1 protein min-1; n = 35). N-benzylimidazole, a nonspecific CYP inhibitor, and various CYP isoform selective inhibitors did not affect BZD N-oxidation. In contrast, formation of BZD N-oxide was almost abolished by heat treatment of microsomes in the absence of NADPH and strongly inhibited by methimazole, a competitive FMO inhibitor. Recombinant FMO3 and FMO1 (which is not expressed in human liver), but not FMO5, showed BZD N-oxidase activity. Respective Km values for FMO3 and FMO1 were 40.4 microM and 23.6 microM, and respective Vmax values for FMO3 and FMO1 were 29.1 and 40.8 nmol mg-1 protein min-1. Human liver samples (n = 35) were analysed for six known FMO3 polymorphisms. The variants I66M, P135L and E305X were not detected. Samples homozygous for the K158 variant showed significantly reduced Vmax values (median 2.7 nmol mg-1 protein min-1) compared to the carriers of at least one wild type allele (median 6.2 nmol mg-1 protein min-1) (P < 0.05, Mann-Whitney-U-test). The V257M and E308G substitutions had no effect on enzyme activity. CONCLUSIONS: BZD N-oxidation in human liver is mainly catalysed by FMO3 and enzyme activity is affected by FMO3 genotype. BZD may be used as a model substrate for human liver FMO3 activity in vitro and may be further developed as an in vivo probe reflecting FMO3 activity.  (+info)

Flavin-containing monooxygenase activity in hepatocytes and microsomes: in vitro characterization and in vivo scaling of benzydamine clearance. (4/17)

Liver microsomes, and more recently cryopreserved hepatocytes, are commonly used in the in vitro characterization of the metabolism of new xenobiotics. The flavin-containing monooxygenases (FMO) are a major non p450 oxidase present in liver microsomes and hepatocytes. Since FMO is known to be thermally labile, and this enzyme may be involved in the metabolic clearance of some drugs, we sought to more completely characterize the metabolic competency of this enzyme in cryopreserved hepatocytes and in liver microsomes preincubated under various conditions using benzydamine as an in vitro and in vivo probe. The metabolism of benzydamine to its major metabolite, the N-oxide, is mediated by FMO3 in humans. We found that the in vitro microsomal t(1/2) was 70% longer when incubations were prewarmed at 37 degrees C in the absence of NADPH compared with prewarming in the presence of an NADPH-regenerating system, and N-oxide formation was inhibited >99%. Interestingly, the in vivo clearance predicted from these incubations and from human hepatocytes overpredicted the observed clearance of benzydamine in humans (>10.5 versus 2.4 ml/min/kg). In contrast, rat hepatocytes successfully predicted rat in vivo benzydamine clearance to within approximately 30% (>68 versus 48 ml/min/kg). Benzydamine N-oxidation in liver microsomes from all common preclinical species demonstrated heat sensitivity. This information should be considered when extrapolating metabolism data of xenobiotics from these in vitro systems.  (+info)

Benzydamine inhibits monocyte migration and MAPK activation induced by chemotactic agonists. (5/17)

1. The present study was aimed to investigate the effect of benzydamine, an anti-inflammatory drug devoid of activity on arachidonic acid metabolism, on monocyte chemotaxis and to define the possible biochemical correlates of activity. 2. Benzydamine inhibited monocyte chemotaxis in response to three classes of chemoattractants: the prototypic CC-chemokine CCL2 (MCP-1), the microbial product fMLP and the complement cascade component C5a. The effect was dose-dependent with IC50's of 100, 50 and 45 microm for MCP-1/CCL2, fMLP and C5a, respectively. At the dose of 100 microm, the effect resulted in a 50+/-10% inhibition of MCP-1/CCL2-induced chemotaxis and 53+/-6 and 54+/-5% inhibitions of chemotaxis in response of fMLP and C5a, respectively (n=3). 3. Receptor expression as well as calcium fluxes in response to chemoattractants were not affected by benzydamine. 4. Benzydamine strongly inhibited chemoattractant-induced activation of the mitogen-activated protein kinase (MAPK) ERK1/2, and of its upstream activator kinase MEK1/2. ERK1/12 activation in response to chemoattractants was 89-98% inhibited by a 100 microm concentration of benzydamine with an IC50 of 30 microm. 5. Under the same experimental conditions, pretreatment with 100 microm benzydamine caused a 75-89% inhibition of p38 activation (IC50 25 microm). 6. These results indicate that the anti-inflammatory activity of benzydamine is exerted at multiple levels, including monocyte migration to chemotactic factors associated to a blockage of ERK and p38 MAPK pathways.  (+info)

Effect of genetic variants of the human flavin-containing monooxygenase 3 on N- and S-oxygenation activities. (6/17)

The decreased capacity of the flavin-containing monooxygenase 3 (FMO3) to oxygenate xenobiotics including trimethylamine is believed to contribute to metabolic disorders. The aim of this study was to functionally characterize FMO3 variants recently found in a Japanese population and compare them with selective functional activity of other FMO3 variants. Recombinant Glu158Lys and Glu158Lys-Glu308Gly FMO3 expressed in Escherichia coli membranes showed slightly decreased N-oxygenation of benzydamine and trimethylamine. Selective functional S-oxygenation of these variants by methyl p-tolyl sulfide or sulindac sulfide was comparable to that of wild-type FMO3. The Glu158Lys-Thr201Lys-Glu308Gly and Val257Met-Met260Val variants showed significantly decreased oxygenation of typical FMO3 substrates (i.e., approximately one-tenth of the V(max)/K(m) values). Val257Met FMO3 had a lower catalytic efficiency for methyl p-tolyl sulfide and sulindac sulfide S-oxygenation. However, compared with wild-type FMO3, Val257Met FMO3 showed a similar catalytic efficiency for N-oxygenation of benzydamine and trimethylamine. The catalytic efficiency for benzydamine and trimethylamine N-oxygenation by Arg205Cys FMO3 was only moderately decreased, but it possessed decreased sulindac sulfide S-oxygenation activity. Kinetic analysis showed that Arg205Cys FMO3 was inhibited by sulindac in a substrate-dependent manner, presumably because of selective interaction between the variant enzyme and the substrate. The results suggest that the effects of genetic variation of human FMO3 could operate at the functional level for N- and S-oxygenation for typical FMO3 substrates. Genetic polymorphism in the human FMO3 gene might lead to unexpected changes of catalytic efficiency for N- and S-oxygenation of xenobiotics and endogenous materials.  (+info)

Inter-individual variation in flavin-containing monooxygenase 3 in livers from Japanese: correlation with hepatic transcription factors. (7/17)

Human flavin-containing monooxygenase 3 (FMO3)-mediated microsomal oxygenation activity, levels of FMO3 protein and FMO3 mRNA and modifications were investigated in Japanese livers genotyped for the FMO3 gene. Significant correlations were observed for benzydamine N-oxygenation or methyl p-tolyl sulfide S-oxygenation activity (in the range of approximately 20- to approximately 40-fold) and FMO3 levels determined immunochemically in liver microsomes (r(2)=0.73-0.75, p<0.0001, n=16). Preincubation with the reducing agent ascorbate revealed that FMO3 activity in some liver samples is suppressed. Microsomal FMO3 protein content (approximately 40-fold) was correlated with FMO3 mRNA levels (r(2)=0.55, p=0.0010, n=16), but FMO3 haplotypes did not affect FMO3 mRNA expression (approximately 100-fold) under the conditions used. FMO3 mRNA levels were multivariately correlated with trans-acting factors, i.e. hepatic nuclear factor 4 (HNF-4) mRNA and nuclear factor Y box-binding protein (NF-Y) mRNA (r(2)=0.31, p=0.0017, n=37). These results suggest that considerable individual differences in FMO3 levels may exist in Japanese livers. The liver-enriched transcription factor HNF-4 appears to be a determinant of FMO3 expression in livers, as well as the ubiquitous factor NF-Y.  (+info)

Recreational use of benzydamine as a hallucinogen among street youth in Brazil. (8/17)

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Benzydamine is a non-steroidal anti-inflammatory drug (NSAID) with local analgesic, anti-inflammatory, and antipyretic properties. It works by inhibiting the production of prostaglandins, which are involved in inflammation, pain perception, and fever. Benzydamine is available as a topical cream, gel, spray, or mouthwash for the relief of pain and inflammation associated with various conditions such as mouth ulcers, sore throat, sprains, strains, and other localized painful and inflammatory conditions. It is not commonly used systemically due to its short half-life and potential for gastrointestinal side effects.

Oxygenases are a class of enzymes that catalyze the incorporation of molecular oxygen (O2) into their substrates. They play crucial roles in various biological processes, including the biosynthesis of many natural products, as well as the detoxification and degradation of xenobiotics (foreign substances).

There are two main types of oxygenases: monooxygenases and dioxygenases. Monooxygenases introduce one atom of molecular oxygen into a substrate while reducing the other to water. An example of this type of enzyme is cytochrome P450, which is involved in drug metabolism and steroid hormone synthesis. Dioxygenases, on the other hand, incorporate both atoms of molecular oxygen into their substrates, often leading to the formation of new carbon-carbon bonds or the cleavage of existing ones.

It's important to note that while oxygenases are essential for many life-sustaining processes, they can also contribute to the production of harmful reactive oxygen species (ROS) during normal cellular metabolism. An imbalance in ROS levels can lead to oxidative stress and damage to cells and tissues, which has been linked to various diseases such as cancer, neurodegeneration, and cardiovascular disease.

A mouthwash is an antiseptic or therapeutic solution that is held in the mouth and then spit out, rather than swallowed. It is used to improve oral hygiene, to freshen breath, and to help prevent dental cavities, gingivitis, and other periodontal diseases.

Mouthwashes can contain a variety of ingredients, including water, alcohol, fluoride, chlorhexidine, essential oils, and other antimicrobial agents. Some mouthwashes are available over-the-counter, while others require a prescription. It is important to follow the instructions for use provided by the manufacturer or your dentist to ensure the safe and effective use of mouthwash.

Mucositis is a common side effect of cancer treatment, particularly chemotherapy and radiation therapy. It's defined as the inflammation and damage to the mucous membranes that line the digestive tract, from the mouth to the anus. This condition can cause symptoms such as pain, redness, swelling, and ulcers in the mouth, throat, esophagus, stomach, and intestines.

Mucositis can make it difficult for patients to eat, drink, and swallow, which can lead to dehydration, malnutrition, and weight loss. It can also increase the risk of infection, as the damaged mucous membranes provide an entry point for bacteria and other microorganisms.

The severity of mucositis can vary depending on the type and dose of chemotherapy or radiation therapy, as well as individual patient factors such as age, overall health status, and genetic makeup. Mucositis typically occurs within a few days to a week after starting cancer treatment and may persist for several weeks or even months after treatment has ended.

Management of mucositis typically involves a combination of strategies, including pain relief, oral hygiene measures, nutritional support, and infection prevention. In severe cases, hospitalization and intravenous fluids may be necessary to prevent dehydration and manage infection.

Povidone-Iodine is a broad-spectrum antimicrobial agent, which is a complex of iodine with polyvinylpyrrolidone (PVP). This complex allows for sustained release of iodine, providing persistent antimicrobial activity. It has been widely used in various clinical settings, including as a surgical scrub, wound disinfection, and skin preparation before invasive procedures. Povidone-Iodine is effective against bacteria, viruses, fungi, and spores. The mechanism of action involves the release of iodine ions, which oxidize cellular components and disrupt microbial membranes, leading to cell death.

I'm sorry for any confusion, but "honey" is not typically considered a medical term. It is a natural sweet substance produced by honeybees from the nectar of flowers. Honey is composed primarily of fructose and glucose, with small amounts of other sugars, water, proteins, amino acids, vitamins, minerals, enzymes, and various organic compounds.

While honey does have some potential health benefits, such as its antimicrobial properties and its use in wound healing, it is not a medical treatment or intervention. If you have any questions about the medicinal uses of honey or its role in health, I would recommend consulting with a healthcare professional.

Stomatitis is a medical term that refers to inflammation of the mucous membrane of any of the soft tissues in the mouth, including the lips, gums, tongue, palate, and cheek lining. It can cause discomfort, pain, and sores or lesions in the mouth. Stomatitis may result from a variety of causes, such as infection, injury, allergic reaction, or systemic diseases. Treatment depends on the underlying cause and may include medications, mouth rinses, or changes in oral hygiene practices.

Sucralfate is a medication that belongs to a class of drugs called aluminum complexes. It's often used in the treatment of gastrointestinal ulcers, including duodenal and gastric ulcers, as well as in the prevention of stress-induced mucosal damage in critically ill patients.

Sucralfate works by forming a protective barrier over the ulcer site, which helps to prevent further damage from acid and digestive enzymes. It's not absorbed into the bloodstream, so it acts locally in the gastrointestinal tract. The medical definition of Sucralfate is:

A synthetic basic aluminum salt of sucrose octasulfate, which is used in the treatment of gastro duodenal ulcers and as a protectant against stress-induced mucosal damage in critically ill patients. It exerts its therapeutic effect by forming a complex, adhesive protective coating over ulcerated areas, thereby preventing further erosion from gastric acid and pepsin.

I'm sorry for any confusion, but "New Zealand" is not a medical term or concept. It is a country located in the southwestern Pacific Ocean, known for its stunning landscapes, unique wildlife, and as the filming location for the "Lord of the Rings" films. If you have any questions related to medicine or health, I'd be happy to try and help answer those for you!

Confidentiality is a legal and ethical principle in medicine that refers to the obligation of healthcare professionals to protect the personal and sensitive information of their patients. This information, which can include medical history, diagnosis, treatment plans, and other private details, is shared between the patient and the healthcare provider with the expectation that it will be kept confidential and not disclosed to third parties without the patient's consent.

Confidentiality is a fundamental component of the trust relationship between patients and healthcare providers, as it helps to ensure that patients feel safe and comfortable sharing sensitive information with their doctors, nurses, and other members of their healthcare team. It also helps to protect patients' privacy rights and uphold their autonomy in making informed decisions about their healthcare.

There are some limited circumstances in which confidentiality may be breached, such as when there is a legal obligation to report certain types of information (e.g., suspected child abuse or neglect), or when the disclosure is necessary to protect the health and safety of the patient or others. However, these exceptions are typically narrowly defined and subject to strict guidelines and safeguards to ensure that confidentiality is protected as much as possible.

In a medical context, feedback refers to the information or data about the results of a process, procedure, or treatment that is used to evaluate and improve its effectiveness. This can include both quantitative data (such as vital signs or laboratory test results) and qualitative data (such as patient-reported symptoms or satisfaction). Feedback can come from various sources, including patients, healthcare providers, medical equipment, and electronic health records. It is an essential component of quality improvement efforts, allowing healthcare professionals to make informed decisions about changes to care processes and treatments to improve patient outcomes.

In the context of healthcare, privacy is often referred to as the state of being free from unauthorized intrusion or observation in regards to one's personal health information. This includes maintaining confidentiality, restricting access to only those who have a legitimate need for the information, and protecting the information from being shared, disclosed, or used inappropriately. It is a fundamental right of individuals and is essential for maintaining trust in the healthcare system.

Computer security, also known as cybersecurity, is the protection of computer systems and networks from theft, damage, or unauthorized access to their hardware, software, or electronic data. This can include a wide range of measures, such as:

* Using firewalls, intrusion detection systems, and other technical safeguards to prevent unauthorized access to a network
* Encrypting sensitive data to protect it from being intercepted or accessed by unauthorized parties
* Implementing strong password policies and using multi-factor authentication to verify the identity of users
* Regularly updating and patching software to fix known vulnerabilities
* Providing security awareness training to employees to help them understand the risks and best practices for protecting sensitive information
* Having a incident response plan in place to quickly and effectively respond to any potential security incidents.

The goal of computer security is to maintain the confidentiality, integrity, and availability of computer systems and data, in order to protect the privacy and safety of individuals and organizations.

I'm sorry for any confusion, but "Moral Obligations" is not a term that has a specific medical definition. The term "moral obligations" is more related to ethics and philosophy, referring to the duties or actions that are considered right or wrong based on a set of moral principles or values.

However, in a broader sense, healthcare professionals may use the term "moral obligations" to refer to their professional responsibility and commitment to providing compassionate, respectful, and high-quality care to all patients, regardless of their background, beliefs, or circumstances. This concept is closely related to medical ethics and professionalism, which provide guidelines for ethical decision-making in clinical practice.

Professional delegation is the process by which a licensed or qualified healthcare professional transfers appropriate responsibilities and tasks to another person while maintaining accountability for the overall outcome of the patient's care. This process involves assigning specific duties to a competent and trained individual, such as a nurse, allied health professional, or other support staff, who have the necessary knowledge, skills, and abilities to perform those tasks safely and effectively.

The purpose of professional delegation is to optimize patient care outcomes by ensuring that tasks are performed by the most appropriate person, allowing healthcare professionals to focus on their areas of expertise and providing opportunities for team members to develop new skills and competencies. Professional delegation requires clear communication, mutual trust, and a shared understanding of roles and responsibilities between the delegating provider and the individual to whom the task is being delegated.

It's important to note that professional delegation does not absolve the delegating provider of their ultimate responsibility for the patient's care. They must ensure that the person receiving the delegated task has the necessary competencies, resources, and support to perform it safely and effectively. Additionally, the delegating provider should maintain ongoing supervision and evaluation of the delegated task to ensure that it is being performed appropriately and that any issues or concerns are addressed promptly.

"Benzydamine oral rinse". Medicinenet. "Difflam spray (benzydamine)". Net Doctor, UK. 8 March 2020. "Tantum Verde (benzydamine ... Fanaki NH, El-Nakeeb MA (March 1996). "Antibacterial activity of benzydamine and antibiotic-benzydamine combinations against ... There are no contraindications to the use of benzydamine except for known hypersensitivity. Benzydamine is well tolerated. ... Benzydamine (also known as Tantum Verde and branded in some countries as Maxtra Gargle, Difflam and Septabene), available as ...
Use of chloroacetamide in the alkylation step, followed by acid hydrolysis produces bendazac (instead of benzydamine). ... Benzydamine Balfour JA, Clissold SP (April 1990). "Bendazac lysine. A review of its pharmacological properties and therapeutic ...
Benztropine Benzydamine Chlorpheniramine Singh A (11 April 2011). Herbalism, Phytochemistry and Ethnopharmacology. Science ...
... and benzydamine. Finally, visual hallucinations, such as those caused by schizophrenia and bipolar disorder, may appear to be ...
... and benzydamine. Benoxaprofen, since withdrawn due to its liver toxicity, was the most photoactive NSAID observed. The ...
QM01AH95 Enflicoxib M01AX01 Nabumetone M01AX02 Niflumic acid M01AX04 Azapropazone M01AX05 Glucosamine M01AX07 Benzydamine ...
Amantadine Amphetamine Amylone Atropine Benztropine Benzydamine Benzylpiperazine Bromocriptine Bupropion Cathinone Cocaine ...
... benzydamine (deliriant and stimulant, used medically as a non-steroidal anti-inflammatory drug) butorphanol (agonist-antagonist ...
... benzydamine MeSH D03.438.449.350 - granisetron MeSH D03.438.473.025 - adrenochrome MeSH D03.438.473.050 - alcian blue MeSH ... benzydamine MeSH D03.383.129.539.487.350 - granisetron MeSH D03.383.129.539.550 - muzolimine MeSH D03.383.129.539.650 - ...
Amantadine Amisulpride Amitriptyline Amoxapine Aripiprazole Asenapine Azacyclonol Beclamide Benactyzine Benfluorex Benzydamine ...
... benzydamine mouthwash) to reduce pain Topical (gels, creams or inhalers) or systemic steroids may be used to reduce ...
... combinations A01AD01 Epinephrine A01AD02 Benzydamine A01AD05 Acetylsalicylic acid A01AD06 Adrenalone A01AD07 Amlexanox A01AD08 ...
ADB 5F-AMB 5F-APINACA AB-CHFUPYCA AB-CHMINACA AB-PINACA ADB-CHMINACA ADB-FUBINACA ADBICA AMB-FUBINACA APICA APINACA Benzydamine ...
R02AD02 Lidocaine R02AD03 Cocaine R02AD04 Dyclonine R02AD05 Ambroxol R02AX01 Flurbiprofen R02AX02 Ibuprofen R02AX03 Benzydamine ...
... benzydamine - Beriplast P - best practice - beta alethine - beta carotene - beta hemolytic streptococcus group B - beta- ...
In painful oral conditions such as aphthous stomatitis, analgesic mouthrinses (e.g. benzydamine mouthwash, or "Difflam") are ...
M02AA01 Phenylbutazone M02AA02 Mofebutazone M02AA03 Clofezone M02AA04 Oxyphenbutazone M02AA05 Benzydamine M02AA06 Etofenamate ...
Benzydamine (INN) Benzyl Benzoate Benzylpenicillin (INN) Benzylsulfamide (INN) Bepadin Bepafant (INN) Beperidium iodide (INN) ...
Cabergoline G02CB04 Quinagolide G02CB05 Metergoline G02CB06 Terguride G02CC01 Ibuprofen G02CC02 Naproxen G02CC03 Benzydamine ...
The molecular formula C19H23N3O (molar mass: 309.40 g/mol, exact mass: 309.1841 u) may refer to: A-412,997 Benzydamine This set ...
"Benzydamine oral rinse". Medicinenet. "Difflam spray (benzydamine)". Net Doctor, UK. 8 March 2020. "Tantum Verde (benzydamine ... Fanaki NH, El-Nakeeb MA (March 1996). "Antibacterial activity of benzydamine and antibiotic-benzydamine combinations against ... There are no contraindications to the use of benzydamine except for known hypersensitivity. Benzydamine is well tolerated. ... Benzydamine (also known as Tantum Verde and branded in some countries as Maxtra Gargle, Difflam and Septabene), available as ...
Hazard - P - B - T - Risk Cannot be excluded. Environmental information is missing on fass.se. It is voluntary for manufacturers to provide information about environmental impact on fass.se. ...
Benzydamine liquid is used as a mouth rinse or gargle to soothe sore areas in the mouth or throat. It should not be swallowed. ... Benzydamine liquid is used to relieve the pain and inflammation associated with a sore throat or with mouth sores caused by ... Dom-Benzydamine is no longer being manufactured for sale in Canada. For brands that may still be available, search under ... Breast-feeding: It is not known if benzydamine passes into breast milk. If you are a breast-feeding mother and are taking this ...
Korolkiewicz RP Recreational abuse with benzydamine hydrochloride (tantum rosa) Clin Toxicol (Phila) 2007 45(2):198-9 ... 500 mg of benzydamine for vaginal application) dissolved in about 250 ml of water. At the time of admission the patient was ... year-old man with a history of cannabinoid and alcohol use who was admitted to the clinic after ingesting 500 mg of benzydamine ... "Recreational abuse with benzydamine hydrochloride (tantum rosa)" Clin Toxicol (Phila). 2007;45(2):198-9. ...
Determination of benzydamine hydrochloride {1-benzyl-3-[3-(dimethylamino)-propoxy]-1H-indazole hydrochloride} in disinfectant ... Determination of benzydamine hydrochloride {1-benzyl-3-[3-(dimethylamino)-propoxy]-1H-indazole hydrochloride} in disinfectant ...
Literature References: Prepn: FR 1382855; Palazzo, US 3318905 (1964, 1967 both to Angelini Francesco); Palazzo et al., J. Med. Chem. 9, 38 (1966). Pharmacology: Lisciani et al., Eur. J. Pharmacol. 3, 157 (1968). Metabolism: Catanese et al., Arzneim.-Forsch. 16, 1354 (1966); Kataoka et al., Chem. Pharm. Bull. 19, 1511 (1971). Toxicology: B. Silvestrini et al., Toxicol. Appl. Pharmacol. 10, 148 (1967). Series of articles on pharmacology: Arzneim.-Forsch. 37, 587-646 (1987). ...
Benzydamine EP/BP Name: Benzydamine Impurity C USP Name: Not Listed Other Names: 1-benzyl-3-hydroxy-1H-indazole CAS Number: ...
Benzydamine mouthwash is a non-steroidal anti-inflammatory medicine used to treat pain and inflammation in the mouth. Learn ... Can I use Benzydamine mouthwash?. *If you have a known allergy or sensitivity to Benzydamine or any of its ingredients, you ... How long should Benzydamine mouthwash be used?. *You must use Benzydamine mouthwash for the period recommended by your doctor. ... When should I eat or drink after using Benzydamine mouthwash? . *It is recommended to wait at least 30 minutes after using ...
Reversion of antibiotic resistance in multidrug-resistant pathogens using non-antibiotic pharmaceutical benzydamine *Yuan Liu ...
Benzydamine mouthwash, curcumin and honey prevent/ reduce oral mucositis severity by ICPA HEALTH PRODUCTS LTD ... Benzydamine mouthwash has been in use for many years. Now, the literature gives the much needed evidence-based confidence to ... Benzydamine mouthwash along with traditional curcumin & honey can prevent or reduce the severity of oral mucositis. This ... Benzydamine reduces radiation-induced toxicity by suppressing selected pro-inflammatory cytokine production - one of the ...
In Vitro Bioactivities of Alcohol-Free Benzydamine Oromucosal Solutions ... w/v benzydamine hydrochloride (HCl) oromucosal solutions.. Material and Methods: The effects of three alcohol-free benzydamine ... alcohol-free; benzydamine; bioactivity; chitosan; poloxamer 407; oromucosal solution. Full Text:. PDF References. Brown TJ, ... Efficacy of topical benzydamine hydrochloride gel on oral mucosal ulcers: an in vivo animal study. Int J Oral Maxillofac Surg ...
Benzydamine. In situ. [68]. Chitosan Antibacterial. Encapsulation of antibacterial agent. Ionic gelation. Average size 10-25 nm ... Vaginal controlled release of benzydamine. Ionic gelation. Average size 128-710 nm range. (Depending on the formulation). ... Vaginal controlled release of benzydamine. Electrospinning. Ionic gelation. Average size 128-710 nm range. (Depends of the ... developed a hybrid system of nanofibers loaded with chitosan nanoparticles for controlled vaginal release of benzydamine. They ...
3-HO-PCP, Benzydamine & Diphenhydramine. 2021 Dec 09. Beautiful Euphoria Blood Is Made of Lead. LukeyTea. Diphenhydramine. 2021 ...
benzydamine. *beta-blockers (e.g., carvedilol, propranolol, timolol). *calcium channel blockers (e.g., amlodipine, diltiazem, ...
Benzydamine. Lozenge (3mg), mouthwash (22.5mg/15ml), spray (1.5mg/ml), gel (10mg/g). Temporary relief of inflammatory ...
Indomethacin and benzydamine were no better than placebo (table 2).. The percentage of patients achieving a successful outcome ... Benzydamine and indomethacin were no different from placebo. In chronic pain conditions (osteoarthritis, tendinitis) placebo ... Confidence intervals for the number needed to treat for ketoprofen did not overlap with those of benzydamine or indomethacin. ... The average response for placebo was similar for individual drugs apart from benzydamine. Ketoprofen, felbinac, ibuprofen, and ...
benzydamine. *beta-adrenergic blockers (e.g., atenolol, propranolol, sotalol). *bisphosphonates (e.g., alendronate, risedronate ...
Tylenol: Acetaminophen belongs to a group of medicines called analgesics (pain relievers) and antipyretics (fever reducers). It works quickly to relieve pain caused by conditions such as headache and osteoarthritis, and to reduce fever caused by infection. Unlike acetylsalicylic acid (ASA), which is also an analgesic and antipyretic, acetaminophen does not reduce inflammation.
Benzydamine plays a role in limiting inflammatory pain induced by neuronal sensitization. Nikolaeva-Koleva M, Espinosa A, ... Effect of econazole and benzydamine on sensory neurons in culture. Mathivanan S, de la Torre-Martinez R, Wolf C, Mangano G, ...
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A 2011 study compared magic mouthwash with 0.15 percent benzydamine hydrochloride. Benzydamine hydrochloride is a medication ... The researchers concluded that magic mouthwash was just as effective as the 0.15 percent benzydamine hydrochloride in helping ... In addition to morphine mouthwash and 0.15 percent benzydamine hydrochloride, other possible treatments for mouth sores include ... 2011). A randomized phase III trial of magic mouthwash and sucralfate versus benzydamine hydrochloride for prophylaxis of ...
Benzydamine HCL 0.15% 100mL Bottle. Used to treat painful inflamed oral conditions such as mouth ulcers. The batch number is ...
Do not use any form of Difflam if you are allergic to benzydamine hydrochloride or any of the other ingredients, and take ... Diffam is a non-steroidal anti-inflammatory drug (NSAID). It contains an active ingredient called benzydamine hydrochloride. ...
phenobarbitone sodium 219 mg (equivalent to phenobarbitone 200 mg) per 1 mL ampoule ...
In relation to benzydamine hydrochloride. *Benzydamine hydrochloride solution 0.15% (Difflam), which is not currently fully ... Benzydamine hydrochloride: full subsidy would be available via prescription endorsement in the community for patients with oral ... Benzydamine. Cancer Treatments Subcommittee of PTAC - 22 March 2013 [PDF, 76 KB] ...
Benzydamine. 200 ng/mL. Chlordiazepoxide. 1,562 ng/mL. Clonazepam. 781 ng/mL. ...
SQUARE Pharmaceuticals PLC. the flagship company of Square Group, is holding the strong leadership position in the pharmaceutical industry of Bangladesh since 1985 and is now on its way to becoming a high performance global player.. ...
Benzydamine hydrochloride and flurbiprofen are painkillers that belong to the group known as NSAIDs (non-steroidal anti- ... A number of good-quality studies have shown that flurbiprofen lozenges and benzydamine hydrochloride given as a spray or gargle ... Lozenges that contain the painkiller benzydamine should not be used while pregnant, unless otherwise advised by your doctor. ... Benzocaine, lignocaine hydrochloride, benzydamine hydrochloride and hexylresorcinol also have local anaesthetic properties. ...
Aktuelle API Auditberichte • GMP-Audits der Herstelung pharmazeutischer Ausgangs- und Wirkstoffe nach ICH Q7 / EU GMP Guide Part II • Diapharm
Roles of benzydamine and cetylpyridinium in acute tonsillitis and acute pharyngitis: the optimum aproach. In: Optimising ...
  • Benzydamine (also known as Tantum Verde and branded in some countries as Maxtra Gargle, Difflam and Septabene), available as the hydrochloride salt, is a locally acting nonsteroidal anti-inflammatory drug (NSAID) with local anaesthetic and analgesic properties for pain relief and anti-inflammatory treatment of inflammatory conditions of the mouth and throat. (wikipedia.org)
  • Is Benzydamine Hydrochloride Market Trapped Between Growth Expectations and Uncertainty? (advancemarketanalytics.com)
  • A new research document titled, Global Benzydamine Hydrochloride Market is released by AdvanceMarketAnalytics. (advancemarketanalytics.com)
  • The market study is a cautious attempt of the industry with strategic steps to the targets of business environment and the ones that are tried to have an essential impression on the progression of the Benzydamine Hydrochloride market. (advancemarketanalytics.com)
  • The Sales Channels, such as Direct, is boosting the Benzydamine Hydrochloride market. (advancemarketanalytics.com)
  • The Form, such as Powdered, is boosting the Benzydamine Hydrochloride market. (advancemarketanalytics.com)
  • The Benzydamine Hydrochloride market is very focused because of the nearness of many key organizations. (advancemarketanalytics.com)
  • The top-down and bottom-up approaches are used to estimate and validate the size of the Global Benzydamine Hydrochloride market. (advancemarketanalytics.com)
  • In order to reach an exhaustive list of functional and relevant players various industry classification standards are closely followed such as NAICS, ICB, SIC to penetrate deep in important geographies by players and a thorough validation test is conducted to reach most relevant players for survey in Benzydamine Hydrochloride market. (advancemarketanalytics.com)
  • I extracted a sachet of Tantum Rosa containing 500 milligrams of Benzydamine hydrochloride using isopropyl alcohol and paper filters. (effectindex.com)
  • This study is aimed at encapsulating Benzydamine Hydrochloride into nanosponges that involve different crosslinkers to polymers in the ratio of 1:1, 1:2, 2:3, etc ., which are used, in order to protect these structures, to control their release and maintain their site-specificity. (ijpsr.com)
  • The pre-formulatory DSC and FTIR study indicated there were no interactions of Benzydamine Hydrochloride (BZH) with excipients (Poly Vinyl Alcohol and Poloxamer 188). (ijpsr.com)
  • Benzydamine Hydrochloride (BZH) is a non-steroidal anti-inflammatory drug used conventionally to treat mouth ulcers. (ijpsr.com)
  • Another study compared magic mouthwash with benzydamine hydrochloride, a drug that decreases swelling, pain, and inflammation. (webmd.com)
  • The results suggested that magic mouthwash that contained an antacid was no more effective for oral mucositis symptoms than benzydamine hydrochloride alone. (webmd.com)
  • A clinical investigation on the possible effects of benzydamine hydrochloride on liver function. (nih.gov)
  • 33. Effect of Honey-Lemon Spray Versus Benzydamine Hydrochloride Spray on Radiation-Induced Acute Oral Mucositis in Head and Neck Cancer Patients: A Pilot, Randomized, Double-Blind, Active-Controlled Clinical Trial. (nih.gov)
  • Benzydamine hydrochloride is an anti-inflammatory drug with analgesic properties of pain relief. (wanttono.com)
  • It contains two active ingredients: benzydamine hydrochloride and chlorhexidine gluconate. (wikikenko.com)
  • Benzydamine hydrochloride is a non-steroidal anti-inflammatory drug (NSAID) that helps reduce pain and inflammation. (wikikenko.com)
  • Its active ingredients, benzydamine hydrochloride, and chlorhexidine gluconate, provide excellent anti-inflammatory and antimicrobial properties that help treat various oral conditions. (wikikenko.com)
  • Benzydamine mouthwash BP 0.15% w/v. 100% Alcohol free Recommended for patients suffering from radiation induced mucositis/Xerostomia. (unvcancure.com)
  • Ours is the known name trusted for providing highly effective Supportive Care Products such as Benzydamine Mouthwash, Whey Plus Protein Powder, Asparcal Tablets and Uviron Tablets. (unvcancure.com)
  • I first gargled with club soda but then got a prescription mouthwash mixture from my oncologist called benzydamine Hcl 015% that I "swish and spit" 4 times/day before meals and at bedtime - does the trick. (cancer.org)
  • Benzydamine liquid is used as a mouth rinse or gargle to soothe sore areas in the mouth or throat. (pharmasave.com)
  • Lon Nol was a Cambodian Prime Minister from 1966 to 1967 and then from 1969 to 1972, and "Lonol" is a benzydamine cream. (funtrivia.com)
  • A crucial role is played by supportive interventions involving analgesic treatment, including topical morphine and benzydamine and a modern approach to pain management - for example, the use of virtual reality. (viamedica.pl)
  • Benzydamine is an anti-inflammatory drug that has anaesthetic qualities, which is why it is found in products for a sore throat. (chemist-4-u.com)
  • Do not use this medication if you are allergic to benzydamine or any ingredients of the medication. (pharmasave.com)
  • For example, this enzyme is likely needed to break down the anticancer drug tamoxifen, the anti-inflammatory medication benzydamine, the antifungal drug ketoconazole, and certain medications used to treat depression (antidepressants). (medlineplus.gov)
  • For brands that may still be available, search under benzydamine oral rinse. (pharmasave.com)
  • Radiation-Induced Oral Mucositis worden onderstaand genoemde aanpak in deze grafiek besproken en vertaal ik maar niet. (kanker-actueel.nl)
  • Benzydamine plays a role in limiting inflammatory pain induced by neuronal sensitization. (nih.gov)
  • List of nationally authorised medicinal products : Active substance(s): benzydamine : Procedure no. (wikipedia.org)
  • Treatment of the enolate of this amide with 3-chloro-1-dimethylamino propane gives benzydamine (5). (wikipedia.org)
  • For treatment associated with radiation therapy , benzydamine should be started the day before the start of radiation therapy and continued daily during the treatment period, as well as after the treatments have stopped, until there is improvement in the discomfort. (pharmasave.com)
  • Benzydamine N-oxidation as an index reaction reflecting FMO activity in human liver microsomes and impact of FMO3 polymorphisms on enzyme activity. (nih.gov)
  • Similar results were obtained when benzydamine N-oxygenation was monitored. (nih.gov)
  • Studies indicate that benzydamine has notable in vitro antibacterial activity and also shows synergism in combination with other antibiotics, especially tetracyclines, against antibiotic-resistant strains of Staphylococcus aureus and Pseudomonas aeruginosa. (wikipedia.org)