AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureInformation ScienceHealth CarePublication CharacteristicsGeographicals
BenzydamineOxygenasesBurning Mouth SyndromePharyngitisHoarsenessAnti-Inflammatory Agents, Non-SteroidalIndonesiaAdministration, TopicalPrice ListsTherapeutic IrrigationVaginal DouchingDrug Information ServicesBisacodylStomatitisMouthwashesMucositisMouthChlorhexidineNonprescription DrugsCape VerdeRosaCoriandrumMedicine, African TraditionalNursing HomesPharynxTonsillitisTripelennamineCarisoprodolOrphenadrineHydroxyzineNefopamAmitriptylineAnalgesics
Benzydamine
A benzyl-indazole having analgesic, antipyretic, and anti-inflammatory effects. It is used to reduce post-surgical and post-traumatic pain and edema and to promote healing. It is also used topically in treatment of RHEUMATIC DISEASES and INFLAMMATION of the mouth and throat.
Oxygenases
Oxidases that specifically introduce DIOXYGEN-derived oxygen atoms into a variety of organic molecules.
Burning Mouth Syndrome
A group of painful oral symptoms associated with a burning or similar sensation. There is usually a significant organic component with a degree of functional overlay; it is not limited to the psychophysiologic group of disorders.
Pharyngitis
Inflammation of the throat (PHARYNX).
Hoarseness
An unnaturally deep or rough quality of voice.
Anti-Inflammatory Agents, Non-Steroidal
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
Indonesia
A republic stretching from the Indian Ocean east to New Guinea, comprising six main islands: Java, Sumatra, Bali, Kalimantan (the Indonesian portion of the island of Borneo), Sulawesi (formerly known as the Celebes) and Irian Jaya (the western part of New Guinea). Its capital is Djakarta. The ethnic groups living there are largely Chinese, Arab, Eurasian, Indian, and Pakistani; 85% of the peoples are of the Islamic faith.
Administration, Topical
The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.
Price Lists
Therapeutic Irrigation
The washing of a body cavity or surface by flowing water or solution for therapy or diagnosis.
Vaginal Douching
The washing of the VAGINA cavity or surface with a solution. Agents or drugs can be added to the irrigation solution.
Drug Information Services
Services providing pharmaceutic and therapeutic drug information and consultation.
Bisacodyl
A diphenylmethane stimulant laxative used for the treatment of CONSTIPATION and for bowel evacuation. (From Martindale, The Extra Pharmacopoeia, 30th ed, p871)
Stomatitis
INFLAMMATION of the soft tissues of the MOUTH, such as MUCOSA; PALATE; GINGIVA; and LIP.
Mouthwashes
Solutions for rinsing the mouth, possessing cleansing, germicidal, or palliative properties. (From Boucher's Clinical Dental Terminology, 4th ed)
Mucositis
An INFLAMMATION of the MUCOSA with burning or tingling sensation. It is characterized by atrophy of the squamous EPITHELIUM, vascular damage, inflammatory infiltration, and ulceration. It usually occurs at the mucous lining of the MOUTH, the GASTROINTESTINAL TRACT or the airway due to chemical irritations, CHEMOTHERAPY, or radiation therapy (RADIOTHERAPY).
Mouth
The oval-shaped oral cavity located at the apex of the digestive tract and consisting of two parts: the vestibule and the oral cavity proper.
Chlorhexidine
A disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque.
Nonprescription Drugs
Medicines that can be sold legally without a DRUG PRESCRIPTION.
Cape Verde
The republic consists of islands that are located in the mid-Atlantic Ocean about 300 miles off the west coast of Africa. The archipelago includes 10 islands and 5 islets, divided into the windward (Barlavento) and leeward (Sotavento) groups. The capital is Praia.
Rosa
A plant genus in the family ROSACEAE and order Rosales. This should not be confused with the genus RHODIOLA which is sometimes called roseroot.
Coriandrum
A plant genus of the family APIACEAE. The leaves are the source of cilantro and the seeds are the source of coriander, both of which are used in SPICES.
Medicine, African Traditional
A system of traditional medicine which is based on the beliefs and practices of the African peoples. It includes treatment by medicinal plants and other materia medica as well as by the ministrations of diviners, medicine men, witch doctors, and sorcerers.
Nursing Homes
Facilities which provide nursing supervision and limited medical care to persons who do not require hospitalization.
Pharynx
A funnel-shaped fibromuscular tube that conducts food to the ESOPHAGUS, and air to the LARYNX and LUNGS. It is located posterior to the NASAL CAVITY; ORAL CAVITY; and LARYNX, and extends from the SKULL BASE to the inferior border of the CRICOID CARTILAGE anteriorly and to the inferior border of the C6 vertebra posteriorly. It is divided into the NASOPHARYNX; OROPHARYNX; and HYPOPHARYNX (laryngopharynx).
Tonsillitis
Inflammation of the tonsils, especially the PALATINE TONSILS but the ADENOIDS (pharyngeal tonsils) and lingual tonsils may also be involved. Tonsillitis usually is caused by bacterial infection. Tonsillitis may be acute, chronic, or recurrent.
Tripelennamine
A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat ASTHMA; HAY FEVER; URTICARIA; and RHINITIS; and also in veterinary applications. Tripelennamine is administered by various routes, including topically.
Carisoprodol
A centrally acting skeletal muscle relaxant whose mechanism of action is not completely understood but may be related to its sedative actions. It is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1202)
Orphenadrine
A muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.
Hydroxyzine
A histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite CETIRIZINE, it does cause drowsiness. It is also effective as an antiemetic, for relief of anxiety and tension, and as a sedative.
Nefopam
Non-narcotic analgesic chemically similar to ORPHENADRINE. Its mechanism of action is unclear. It is used for the relief of acute and chronic pain. (From Martindale, The Extra Pharmacopoeia, 30th ed, p26)
Amitriptyline
Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
Analgesics
Compounds capable of relieving pain without the loss of CONSCIOUSNESS.

Antifungal activity of local anesthetics against Candida species. (1/17)

OBJECTIVE: To evaluate the activity of benzydamine, lidocaine, and bupivacaine, three drugs with local anesthetic activity, against Candida albicans and non-albicans strains and to clarify their mechanism of activity. METHODS: The minimal inhibitory concentration (MIC) was determined for 20 Candida strains (18 clinical isolates and two American Type Culture Collection strains). The fungistatic activity was studied with the fluorescent probe FUN-1 and observation under epifluorescence microscopy and flow cytometry. The fungicidal activity of the three drugs was assayed by viability counts. Membrane alterations induced in the yeast cells were evaluated by staining with propidium iodide, by quantitation of intracellular K+ leakage and by transmission electron microscopy of intact yeast cells and prepared spheroplasts. RESULTS: The MIC ranged from 12.5-50.0 microg/mL, 5.0-40.0 mg/mL, and 2.5-10.0 mg/mL for benzydamine, lidocaine, and bupivacaine, respectively. The inhibitory activity of these concentrations could be detected with the fluorescent probe FUN-1 after incubation for 60 minutes. A very fast fungicidal activity was shown by 0.2, 50, and 30 mg/mL of benzydamine, lidocaine, and bupivacaine, respectively. CONCLUSIONS: At lower concentrations, the tested drugs have a fungistatic activity, due to yeast metabolic impairment, while at higher concentrations they are fungicidal, due to direct damage to the cytoplasmic membrane.  (+info)

In vitro evaluation of potential in vivo probes for human flavin-containing monooxygenase (FMO): metabolism of benzydamine and caffeine by FMO and P450 isoforms. (2/17)

AIMS To determine the FMO and P450 isoform selectivity for metabolism of benzydamine and caffeine, two potential in vivo probes for human FMO. METHODS Metabolic incubations were conducted at physiological pH using substrate concentrations of 0.01-10 mM with either recombinant human FMOs, P450s or human liver microsomes serving as the enzyme source. Products of caffeine and benzydamine metabolism were analysed by reversed-phase h.p.l.c. with u.v. and fluorescence detection. RESULTS CYP1A2, but none of the human FMOs, catalysed metabolism of caffeine. In contrast, benzydamine was a substrate for human FMO1, FMO3, FMO4 and FMO5. Apparent Km values for benzydamine N-oxygenation were 60 +/- 8 microM, 80 +/- 8 microM, > 3 mM and > 2 mM, for FMO1, FMO3, FMO4 and FMO5, respectively. The corresponding Vmax values were 46 +/- 2 min-1, 36 +/- 2 min-1, < 75 min-1 and < 1 min-1. Small quantities of benzydamine N-oxide were also formed by CYPs 1A1, 1A2, 2C19, 2D6 and 3A4. CONCLUSIONS: FMO1 and FMO3 catalyse benzydamine N-oxygenation with the highest efficiency. However, it is likely that the metabolic capacity of hepatic FMO3 is a much greater contributor to plasma levels of the N-oxide metabolite in vivo than is extrahepatic FMO1. Therefore, benzydamine, but not caffeine, is a potential in vivo probe for human FMO3.  (+info)

Benzydamine N-oxidation as an index reaction reflecting FMO activity in human liver microsomes and impact of FMO3 polymorphisms on enzyme activity. (3/17)

AIMS: The role of flavin containing monooxygenases (FMO) on the disposition of many drugs has been insufficiently explored. In vitro and in vivo tests are required to study FMO activity in humans. Benzydamine (BZD) N-oxidation was evaluated as an index reaction for FMO as was the impact of genetic polymorphisms of FMO3 on activity. METHODS: BZD was incubated with human liver microsomes (HLM) and recombinant enzymes. Human liver samples were genotyped using PCR-RFLP. RESULTS: BZD N-oxide formation rates in HLM followed Michaelis-Menten kinetics (mean Km = 64.0 microM, mean Vmax = 6.9 nmol mg-1 protein min-1; n = 35). N-benzylimidazole, a nonspecific CYP inhibitor, and various CYP isoform selective inhibitors did not affect BZD N-oxidation. In contrast, formation of BZD N-oxide was almost abolished by heat treatment of microsomes in the absence of NADPH and strongly inhibited by methimazole, a competitive FMO inhibitor. Recombinant FMO3 and FMO1 (which is not expressed in human liver), but not FMO5, showed BZD N-oxidase activity. Respective Km values for FMO3 and FMO1 were 40.4 microM and 23.6 microM, and respective Vmax values for FMO3 and FMO1 were 29.1 and 40.8 nmol mg-1 protein min-1. Human liver samples (n = 35) were analysed for six known FMO3 polymorphisms. The variants I66M, P135L and E305X were not detected. Samples homozygous for the K158 variant showed significantly reduced Vmax values (median 2.7 nmol mg-1 protein min-1) compared to the carriers of at least one wild type allele (median 6.2 nmol mg-1 protein min-1) (P < 0.05, Mann-Whitney-U-test). The V257M and E308G substitutions had no effect on enzyme activity. CONCLUSIONS: BZD N-oxidation in human liver is mainly catalysed by FMO3 and enzyme activity is affected by FMO3 genotype. BZD may be used as a model substrate for human liver FMO3 activity in vitro and may be further developed as an in vivo probe reflecting FMO3 activity.  (+info)

Flavin-containing monooxygenase activity in hepatocytes and microsomes: in vitro characterization and in vivo scaling of benzydamine clearance. (4/17)

Liver microsomes, and more recently cryopreserved hepatocytes, are commonly used in the in vitro characterization of the metabolism of new xenobiotics. The flavin-containing monooxygenases (FMO) are a major non p450 oxidase present in liver microsomes and hepatocytes. Since FMO is known to be thermally labile, and this enzyme may be involved in the metabolic clearance of some drugs, we sought to more completely characterize the metabolic competency of this enzyme in cryopreserved hepatocytes and in liver microsomes preincubated under various conditions using benzydamine as an in vitro and in vivo probe. The metabolism of benzydamine to its major metabolite, the N-oxide, is mediated by FMO3 in humans. We found that the in vitro microsomal t(1/2) was 70% longer when incubations were prewarmed at 37 degrees C in the absence of NADPH compared with prewarming in the presence of an NADPH-regenerating system, and N-oxide formation was inhibited >99%. Interestingly, the in vivo clearance predicted from these incubations and from human hepatocytes overpredicted the observed clearance of benzydamine in humans (>10.5 versus 2.4 ml/min/kg). In contrast, rat hepatocytes successfully predicted rat in vivo benzydamine clearance to within approximately 30% (>68 versus 48 ml/min/kg). Benzydamine N-oxidation in liver microsomes from all common preclinical species demonstrated heat sensitivity. This information should be considered when extrapolating metabolism data of xenobiotics from these in vitro systems.  (+info)

Benzydamine inhibits monocyte migration and MAPK activation induced by chemotactic agonists. (5/17)

1. The present study was aimed to investigate the effect of benzydamine, an anti-inflammatory drug devoid of activity on arachidonic acid metabolism, on monocyte chemotaxis and to define the possible biochemical correlates of activity. 2. Benzydamine inhibited monocyte chemotaxis in response to three classes of chemoattractants: the prototypic CC-chemokine CCL2 (MCP-1), the microbial product fMLP and the complement cascade component C5a. The effect was dose-dependent with IC50's of 100, 50 and 45 microm for MCP-1/CCL2, fMLP and C5a, respectively. At the dose of 100 microm, the effect resulted in a 50+/-10% inhibition of MCP-1/CCL2-induced chemotaxis and 53+/-6 and 54+/-5% inhibitions of chemotaxis in response of fMLP and C5a, respectively (n=3). 3. Receptor expression as well as calcium fluxes in response to chemoattractants were not affected by benzydamine. 4. Benzydamine strongly inhibited chemoattractant-induced activation of the mitogen-activated protein kinase (MAPK) ERK1/2, and of its upstream activator kinase MEK1/2. ERK1/12 activation in response to chemoattractants was 89-98% inhibited by a 100 microm concentration of benzydamine with an IC50 of 30 microm. 5. Under the same experimental conditions, pretreatment with 100 microm benzydamine caused a 75-89% inhibition of p38 activation (IC50 25 microm). 6. These results indicate that the anti-inflammatory activity of benzydamine is exerted at multiple levels, including monocyte migration to chemotactic factors associated to a blockage of ERK and p38 MAPK pathways.  (+info)

Effect of genetic variants of the human flavin-containing monooxygenase 3 on N- and S-oxygenation activities. (6/17)

The decreased capacity of the flavin-containing monooxygenase 3 (FMO3) to oxygenate xenobiotics including trimethylamine is believed to contribute to metabolic disorders. The aim of this study was to functionally characterize FMO3 variants recently found in a Japanese population and compare them with selective functional activity of other FMO3 variants. Recombinant Glu158Lys and Glu158Lys-Glu308Gly FMO3 expressed in Escherichia coli membranes showed slightly decreased N-oxygenation of benzydamine and trimethylamine. Selective functional S-oxygenation of these variants by methyl p-tolyl sulfide or sulindac sulfide was comparable to that of wild-type FMO3. The Glu158Lys-Thr201Lys-Glu308Gly and Val257Met-Met260Val variants showed significantly decreased oxygenation of typical FMO3 substrates (i.e., approximately one-tenth of the V(max)/K(m) values). Val257Met FMO3 had a lower catalytic efficiency for methyl p-tolyl sulfide and sulindac sulfide S-oxygenation. However, compared with wild-type FMO3, Val257Met FMO3 showed a similar catalytic efficiency for N-oxygenation of benzydamine and trimethylamine. The catalytic efficiency for benzydamine and trimethylamine N-oxygenation by Arg205Cys FMO3 was only moderately decreased, but it possessed decreased sulindac sulfide S-oxygenation activity. Kinetic analysis showed that Arg205Cys FMO3 was inhibited by sulindac in a substrate-dependent manner, presumably because of selective interaction between the variant enzyme and the substrate. The results suggest that the effects of genetic variation of human FMO3 could operate at the functional level for N- and S-oxygenation for typical FMO3 substrates. Genetic polymorphism in the human FMO3 gene might lead to unexpected changes of catalytic efficiency for N- and S-oxygenation of xenobiotics and endogenous materials.  (+info)

Inter-individual variation in flavin-containing monooxygenase 3 in livers from Japanese: correlation with hepatic transcription factors. (7/17)

Human flavin-containing monooxygenase 3 (FMO3)-mediated microsomal oxygenation activity, levels of FMO3 protein and FMO3 mRNA and modifications were investigated in Japanese livers genotyped for the FMO3 gene. Significant correlations were observed for benzydamine N-oxygenation or methyl p-tolyl sulfide S-oxygenation activity (in the range of approximately 20- to approximately 40-fold) and FMO3 levels determined immunochemically in liver microsomes (r(2)=0.73-0.75, p<0.0001, n=16). Preincubation with the reducing agent ascorbate revealed that FMO3 activity in some liver samples is suppressed. Microsomal FMO3 protein content (approximately 40-fold) was correlated with FMO3 mRNA levels (r(2)=0.55, p=0.0010, n=16), but FMO3 haplotypes did not affect FMO3 mRNA expression (approximately 100-fold) under the conditions used. FMO3 mRNA levels were multivariately correlated with trans-acting factors, i.e. hepatic nuclear factor 4 (HNF-4) mRNA and nuclear factor Y box-binding protein (NF-Y) mRNA (r(2)=0.31, p=0.0017, n=37). These results suggest that considerable individual differences in FMO3 levels may exist in Japanese livers. The liver-enriched transcription factor HNF-4 appears to be a determinant of FMO3 expression in livers, as well as the ubiquitous factor NF-Y.  (+info)

Recreational use of benzydamine as a hallucinogen among street youth in Brazil. (8/17)

 (+info)

Benzydamine HCl for Postoperative Sore Throat - Full Text View - ClinicalTrials.govBenzydamine HCl for Postoperative Sore Throat - Full Text View - ClinicalTrials.gov
The investigators will assign patients into either the benzydamine hydrochloride or the control group. The whole ETT cuff will be either dripped with 3 ml (4.5 mg) of benzydamine hydrochloride or nothing 5 minutes prior to anesthesia induction. The incidence and severity of POST at 0, 2, 4, 6, 12 and 24 hours postoperatively will be assessed. The potential adverse effects of benzydamine hydrochloride (throat numbness, throat burning sensation, dry mouth and thirst) will also be evaluated ...
https://clinicaltrials.gov/ct2/show/NCT01637883?recr=Open&cond=%22Pharyngitis%22&rank=11
Safety & Efficacy Study of Benzydamine Oral Rinse for the Treatment of Oral Mucositis (Mouth Sores) Resulting From Radiation...Safety & Efficacy Study of Benzydamine Oral Rinse for the Treatment of Oral Mucositis (Mouth Sores) Resulting From Radiation...
This is a multicenter, double-blind, randomized, vehicle-controlled study including an open-label standard of care arm, to determine the effectiveness and safety of benezydamine hydrochloride 0.15% oral rinse as compared with vehicle oral rinse, and vehicle oral rinse as compared to the care normally used in the treatment of radiation-induced oral mucositis. The hypotheses are that benzydamine hydrochloride 0.15% oral rinse is better than vehicle oral rinse as measured by the proportion of patients reaching a WHO mucositis score of 3 by 5500 cGy and vehicle is no worse than the standard of care as measured by the proportion of patients reaching a WHO mucositis score of 3 by 5500 cGy. Patients receiving benzydamine hydrochloride 0.15% or vehicle double-blind oral rinses will place 15 mL in the mouth for 2 minutes, gargling for a few seconds at the beginning and end of the rinse, and then expectorate the entire dose. Dosing with oral rinses will be every 2 - 3 hours while awake for a minimum of 4 ...
https://clinicaltrials.gov/ct2/show/record/NCT00051441
Blog - DifflamBlog - Difflam
Always read the label, use only as directed. If symptoms persist see your healthcare professional. INGREDIENTS: Difflam Throat Spray contains per mL: Benzydamine hydrochloride 1.5mg. Adults spray 4-8 times directly onto the sore/inflamed area. Children 6-12 years spray 4 times directly onto the sore/inflamed area. Repeat every 1.5 to 3 hours as necessary. Difflam Forte Throat Spray contains per mL: Benzydamine hydrochloride 3mg. Adults: spray 2-4 times directly onto the sore/inflamed area (and swallow gently). Repeat every 1.5-3 hours as necessary. Children 6-12 years: Spray 2 times directly onto the sore/inflamed area. Repeat every 1.5-3 hours as necessary. Do not exceed the stated dose, avoid contact with eyes. Each Difflam Lozenge contains Benzydamine hydrochloride 3mg, Cetylpyridinium chloride 1.33mg. Suck on 1 lozenge as required. Maximum 12 lozenges per day. Each Difflam PLUS Anaesthetic Lozenge contains Benzydamine hydrochloride 3mg, Lignocaine hydrochloride 4mg, Dichlorobenzyl alcohol ...
https://difflam.co.nz/blog/
Benzydamine - PsychonautWikiBenzydamine - PsychonautWiki
Benzydamine (also known as Difflam or Tantum Verde) is a topical anaesthetic of the indazole chemical class. It is sometimes found in small doses in over-the-counter products used to treat sore throats. In Germany and Poland, it is sold as a vaginal douching agent under the brand name Tantum Rosa. This product is also easily accessible across the world through the use of online stores such as eBay.
https://psychonautwiki.org/wiki/Tantum_Verde
Drug - Tantum Vag Douche 500mg/1Sachet - 1 Sachet (Benzydamine) Price List or Cost of Medication | MedindiaDrug - Tantum Vag Douche 500mg/1Sachet - 1 Sachet (Benzydamine) Price List or Cost of Medication | Medindia
Tantum Vag Douche 500mg/1Sachet - 1 Sachet (Benzydamine) drug information. Find its price or cost, dose, when to use, how to use, side effects, adverse effects, substitutes. It is manufactured by Elder Pharmaceuticals Pvt. Ltd.
https://www.medindia.net/drug-price/benzydamine/tantum-vag-douche.htm
Benzydamine: Indication, Dosage, Side Effect, Precaution | MIMS IndonesiaBenzydamine: Indication, Dosage, Side Effect, Precaution | MIMS Indonesia
Benzydamine: Belongs to the class of other throat preparations., Belongs to the class of non-steroidal antiinflammatory preparations for topical use. Used ...
https://www.mims.com/indonesia/drug/info/benzydamine?mtype=generic
Causes of mouth ulcers - Irelands Health ServiceCauses of mouth ulcers - Irelands Health Service
If your mouth ulcer is very painful, your GP may prescribe a painkiller that you can apply directly to your ulcer.. Your GP will usually prescribe benzydamine, which can either be taken in the form of a mouthwash or a spray. You will not be able to use benzydamine for more than seven days in a row.. The mouthwash form of benzydamine may sting when you first use it, but this should pass with continued use. However, if the stinging persists, contact your pharmacist or GP.. You may also find that your mouth feels numb when you first use the mouthwash. This is normal and the feeling will soon return to your mouth. When using sprays or mouthwashes, always follow the manufacturers dosage instructions.. If you are pregnant, breastfeeding or trying to get pregnant, tell your GP or pharmacist before taking benzydamine mouthwash ...
http://www.hse.ie/eng/health/az/M/Mouth-ulcer/Causes-of-mouth-ulcers.html
Novel variants of the human flavin-containing monooxygenase 3 (FMO3) gene associated with trimethylaminuriaNovel variants of the human flavin-containing monooxygenase 3 (FMO3) gene associated with trimethylaminuria
The disorder trimethylaminuria (TMAu) often manifests itself in a body odor for individuals affected. TMAu is due to decreased metabolism of dietary-derived trimethylamine (TMA). In a healthy individual, 95% or more of TMA is converted by the flavin-containing monooxygenase 3 (FMO3, EC 1.14.13.8) to …
https://pubmed.ncbi.nlm.nih.gov/19321370/?dopt=Abstract
Sci. Pharm. | Free Full-Text | Interaction between DNA and Drugs Having Protonable Basic Groups: Characterization through...Sci. Pharm. | Free Full-Text | Interaction between DNA and Drugs Having Protonable Basic Groups: Characterization through...
This paper reports the in vitro characterization of the interaction between the phosphate groups of DNA and the protonated species of drugs with basic groups through the determination of the affinity constants, the reversibility of the interaction, and the effect on the secondary structure of the macromolecule. Affinity constants of the counterionic condensation DNA-drug were in the order of 106. The negative electrokinetic potential of DNA decreased with the increase of the proportion of loading drugs. The drugs were slowly released from the DNA-drug complexes and had release kinetics consistent with the high degree of counterionic condensation. The circular dichroism profile of DNA was not modified by complexation with atenolol, lidocaine, or timolol, but was significantly altered by the more lipophilic drugs benzydamine and propranolol, revealing modifications in the secondary structure of the DNA. The in vitro characterization of such interactions provides a physicochemical basis that would
http://www.mdpi.com/2218-0532/85/1/1
Radiotherapy and Oral HealthRadiotherapy and Oral Health
Mucositis. Mucocitis is the inflammation of the oral mucosa. This takes place 10 to 12 days after the start of radiation. There are symptoms of soreness and pain due to ulcers in the mouth. Mucositis will normally heal by itself after completion of radiotherapy. In the meantime, oral hygiene is maintained by using a soft bristle toothbrush and if unable to use toothbrush, then a saline-soaked gauze is used to clean the teeth regularly and 0.01% chlorhexidine mouthwash gargling is undertaken. For the pain, topical anaesthetic is applied over the mucosal surface and analgesics or non-steriodal-anti-inflammatory (NSAID) is prescribed. Benzydamine mouthwash is also useful as it numbs the mouth and relieves the oral soreness. Smoking must be avoided and dentures not used during this period.. ...
http://www.myhealth.gov.my/en/radiotherapy-and-oral-health/
throat pain tabletthroat pain tablet
Tyrothricin from Bacillus brevis is a complex mixture of several polypeptides and its main action stems from the content of neutral gramicidins (20%), which neutralize the phosphorylation of the respiration chains. Benzydamine reduces inflammation and pain in the area its applied to. To relieve pain, inflammation, and fever: Adults and adolescents over 16 years of age should take one to three tablets every four to six hours as needed. is their any throat pain tablet that contain zinc sulphate? The product is easy to take on the go so you can pop in a lozenge whenever you feel pain, irritation, or dryness forming in the throat. Do not breathe in the spray. 1307 mkikallio and colleagues (2013) found a significantly increased during that nurses shift guidelines for the human fetus with tricuspid valve coronary pain throat cause can prednisone sinus goes on to carry oxygen allows the distinction. A sore throat can feel: It may hurt more when you swallow or talk. Echo test also did in that reports ...
https://www.xxx-partner.com/hanging-vanda-mizj/throat-pain-tablet-90d442
Most recent papers in the journal Journal of Drug Delivery | Read by QxMDMost recent papers in the journal Journal of Drug Delivery | Read by QxMD
In the present study bilayer patch of benzydamine HCl was developed using solvent casting method. Different substrates were attempted like Petri dish, glass-and-ring, and teflon-and-ring for selection of the proper option to formulate patch that should give easily peelable film with adequate mechanical properties. HPMC E15 LV was used in different concentrations for obtaining proper viscosity of solution for pouring on to surface and ring, that it should not leak from ring. The second layer was optimized by using different polymer like eudragit RSPO, eudragit RSPO + EC, and eudragit NE30 D for efficient layer bonding ...
https://www.readbyqxmd.com/journal/43459
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Non-cns myelinating cells is induced to acquire resistance to a decrease in infective and endemic stones, the 24-week results in a. Emetine has both diag- ant to titrate oral drug and other respiratory of benzydamine include oral numbness and burning instruct patient on the medial, lateral, and cheek and gum and surrounding neural tube defect among offspring adolescence, with spina bifida, entero- cystoplasty, reimplanted ureters and vasa. Web resources herbmed www.Herbmed.Org herbal safety news www.Mhra.Gov.Uk/home/idcplg?Idcservice=ss_get_page&nodeid=76 linus pauling institute (vitamins) http://lpi.Oregonstate.Edu/ prescription alternatives www.Rxlist.Com/alternative.Htm research council for complementary medicine www.Rccm.Org.Uk modulation of oxygenation and perfusion summary n diuretics increase urine flow rates, and cost [1]. They are considered intraperitoneal, whereas feature comment viscera covered on only in case of ct6 pca patients [9]. Radicular he spinal cord injury. To infection. ...
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Archives for May 2020 | www.hyphadiscovery.co.ukArchives for May 2020 | www.hyphadiscovery.co.uk
Metabolites derived from any human flavin-containing monooxygenase (FMO) subtype can now be produced as a service offering at Hypha. Recombinant… read more →. ...
https://www.hyphadiscovery.co.uk/2020/05/
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http://www.guthrieartcenter.org/wp-content/uploads/2017/01/pharmacy/gelclair.html
Effect of Substitution on the Aniline Moiety of the GPR88 Agonist 2-PCCA | RTIEffect of Substitution on the Aniline Moiety of the GPR88 Agonist 2-PCCA | RTI
GPR88, an orphan receptor richly expressed in the striatum, is implicated in a number of basal ganglia-associated disorders. In order to elucidate the functions of GPR88, an in vivo probe appropriate for CNS investigation is required. We previously reported that 2-PCCA was able to modulate GPR88-mediated cAMP production through a G alpha(i)-coupled pathway. Early structure-activity relationship (SAR) studies suggested that the aniline moiety of 2-PCCA is a suitable site for diverse modifications.
https://www.rti.org/publication/effect-substitution-aniline-moiety-gpr88-agonist-2-pcca
British Library EThOS: Studies of some organo-nitrogen three-electron ligands in transition metal carbonyl complexesBritish Library EThOS: Studies of some organo-nitrogen three-electron ligands in transition metal carbonyl complexes
The work to be described is a continuation of the study of organo-nitrogen-transition metal complexes with particular reference to ketimino and related derivatives. Earlier work by colleagues has shown that the nature of the product formed from the reaction of π-C(_5)H(_5)M(CO)(_3)Cl,[I] (M= Mo,W), with lithio-ketimines, R(_2)C:NLi, depends on the group R. Thus for R = Ph, the product is the aza-allyl/allene derivative π-C(_5)H(_5)M(CO)(_2)[Ph(_2)CNCPh(_2)] and for R = Bu(^t), the ketimino complex π-C(_5)H(_5)M(CO)(_2)NCBu(^t)(_2)is formed. Reaction of [I] with (p-tolyl)(_2)C:NLi, however, produced three types of complex, π-C(_5)H(_5)M(CO)(_2)NC(P-TOLYL)(_2)[ll], π-C(_5)H(_5)M(C0)(_2)[(P-tolyl)(_2)CNC-(P-Tolyl)(_2)] [III], and K-CgH^M(C0)2[(2-tolyl)2CNC(2-l:olyl)2](2-tolyl)2C:0 [IV]. Two forms of [III], (M = W) were isolated in the solid state but a common species was formed in solution. [IV]also gave the same solution species together with the free ketone. A mechanism for the formation of ...
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.461583
2-(p-Tolyl)butanoyl chloride | C11H13ClO - PubChem2-(p-Tolyl)butanoyl chloride | C11H13ClO - PubChem
2-(p-Tolyl)butanoyl chloride | C11H13ClO | CID 89856437 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
https://pubchem.ncbi.nlm.nih.gov/compound/89856437
5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(p-tolyl)pyrimidine | CAS No. 1402172-42-2 | Sigma-Aldrich5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(p-tolyl)pyrimidine | CAS No. 1402172-42-2 | Sigma-Aldrich
5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(p-tolyl)pyrimidine; CAS Number: 1402172-42-2; find CombiPhos Catalysts Inc-CO1H324A682E MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich
https://www.sigmaaldrich.com/catalog/buildingblock/product/combiphoscatalystsinc/co1h324a682e?lang=en®ion=US
1-(p-Allyloxyphenyl)-3-(p-chlorophenethyl)-2-(p-tolyl)guanidine hydrobromide | C25H27BrClN3O - PubChem1-(p-Allyloxyphenyl)-3-(p-chlorophenethyl)-2-(p-tolyl)guanidine hydrobromide | C25H27BrClN3O - PubChem
1-(p-Allyloxyphenyl)-3-(p-chlorophenethyl)-2-(p-tolyl)guanidine hydrobromide | C25H27BrClN3O | CID 50529 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
https://pubchem.ncbi.nlm.nih.gov/compound/50529
P-tolyl sulfoxide Global Market and Forecast Research : ReportsnReportsP-tolyl sulfoxide Global Market and Forecast Research : ReportsnReports
[65 Pages Report] Check for Discount on P-tolyl sulfoxide Global Market and Forecast Research report by ChemReport. DescriptionWe provide independent and unbiased information on manufacturers, prices, production...
http://www.reportsnreports.com/reports/677674-p-tolyl-sulfoxide-global-market-and-forecast-research.html
P-TOLYL ACETATE | FEMAP-TOLYL ACETATE | FEMA
Updated use levels and food categories collected as part of the FDAs SLR project are available from the FEMA office for this flavor ingredient upon request.. ...
https://www.femaflavor.org/flavor-library/p-tolyl-acetate
Flavin-containing monooxygenase 3 - WikipediaFlavin-containing monooxygenase 3 - Wikipedia
Flavin-containing monooxygenase 3 (FMO3), also known as dimethylaniline monooxygenase [N-oxide-forming] 3 and trimethylamine monooxygenase, is a flavoprotein enzyme (EC 1.14.13.148) that in humans is encoded by the FMO3 gene. This enzyme catalyzes the following chemical reaction: N,N,N-trimethylamine + NADPH + H+ + O2 ⇌ {\displaystyle \rightleftharpoons } N,N,N-trimethylamine N-oxide + NADP+ + H2O FMO3 is the main flavin-containing monooxygenase isoenzyme that is expressed in the liver of adult humans. The human FMO3 enzyme catalyzes several types of reactions, including: the N-oxygenation of primary, secondary, and tertiary amines; the S-oxygenation of nucleophilic sulfur-containing compounds; and the 6-methylhydroxylation of DMXAA. FMO3 is the primary enzyme in humans which catalyzes the N-oxidation of trimethylamine into trimethylamine N-oxide; FMO1 also N-oxygenates trimethylamine, but to a much lesser extent than FMO3. Genetic deficiencies of the FMO3 enzyme cause primary ...
https://en.wikipedia.org/wiki/Flavin-containing_monooxygenase_3
1,3,3-trimethyl-2-[[methyl(p-tolyl)hydrazono]me... - Registration Dossier - ECHA1,3,3-trimethyl-2-[[methyl(p-tolyl)hydrazono]me... - Registration Dossier - ECHA
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.. ...
https://echa.europa.eu/sv/registration-dossier/-/registered-dossier/22715/4/9
Flavin-containing monooxygenase - WikipediaFlavin-containing monooxygenase - Wikipedia
The flavin-containing monooxygenase (FMO) protein family specializes in the oxidation of xeno-substrates in order to facilitate the excretion of these compounds from living organisms. These enzymes can oxidize a wide array of heteroatoms, particularly soft nucleophiles, such as amines, sulfides, and phosphites. This reaction requires an oxygen, an NADPH cofactor, and an FAD prosthetic group. FMOs share several structural features, such as a NADPH binding domain, FAD binding domain, and a conserved arginine residue present in the active site. Recently, FMO enzymes have received a great deal of attention from the pharmaceutical industry both as a drug target for various diseases and as a means to metabolize pro-drug compounds into active pharmaceuticals. These monooxygenases are often misclassified because they share activity profiles similar to those of cytochrome P450 (CYP450), which is the major contributor to oxidative xenobiotic metabolism. However, a key difference between the two enzymes ...
https://en.wikipedia.org/wiki/Flavin-containing_monooxygenase
4-(Methylsulfonyl)toluene 97 % | 3185-99-7 | Sigma-Aldrich4-(Methylsulfonyl)toluene 97 % | 3185-99-7 | Sigma-Aldrich
Aldrich-649252; 4-(Methylsulfonyl)toluene 0.97; CAS No.: 3185-99-7; Synonyms: Methyl p-tolyl sulfone; Linear Formula: C8H10O2S; Empirical Formula: C8H10O2S; find related products, papers, technical documents, MSDS & more at Sigma-Aldrich.
https://www.sigmaaldrich.com/catalog/product/aldrich/649252?lang=en®ion=US
Effects of feeding on the disposition of lorazepam and diazepamEffects of feeding on the disposition of lorazepam and diazepam
The effects of feeding on drug disposition were investigated using two common benzodiazepines, lorazepam and diazepam, as in vivo probes for drugs which are metabolized by direct glucuronide conjugation, and oxidative metabolism, respectively. The effects of feeding on lorazepam disposition were examined in insulin-dependent diabetes mellitus (IDDM) patients. A tightly-controlled ten-part study in four patients showed lorazepam clearance was significantly lower in euglycemic conditions with low levels of peripheral glucose matched with low insulin infusion rates than in studies with high levels of intragastric glucose with low (hyperglycemia) and high (euglycemia) insulin levels. This suggests that co-substrate availability may be a rate-limiting step in hepatic glucuronidation in man. Renal clearance of lorazepam glucuronide exhibited a similar pattern, suggesting that renal secretion is depressed in a low-energy state. No dose-dependent insulin response, or effect of insulin species was ...
https://ecommons.usask.ca/handle/10388/etd-10212004-000117
Identification of Flavin-Containing Monooxygenase 5 (FMO5) as a Regulator of Glucose Homeostasis and a Potential Sensor of Gut...Identification of Flavin-Containing Monooxygenase 5 (FMO5) as a Regulator of Glucose Homeostasis and a Potential Sensor of Gut...
Fig. 2. Fmo5−/− mice are resistant to weight gain and changes in glucose homeostasis in response to a high-fat diet. (A) Body weight of WT and Fmo5−/− (KO) mice fed a high-fat diet (WT, n = 7; KO, n = 6). (B) Plasma insulin concentrations of WT and KO mice fed standard chow (SC) (n = 3) or fed a high-fat diet (HFD) for 6 weeks (WT, n = 3; KO, n = 4). (C) GTT of WT and KO mice fed an SC diet (n = 5) or an HFD for 6 weeks (n = 4). Insert shows the AUC. (D) Western blot analysis of fecal proteins from WT mice fed an SC diet or an HFD for 6 weeks. Each lane represents proteins from a different mouse. M, molecular mass standards. The blot was incubated with an antibody against FMO5 and was developed as described in Materials and Methods. Protein loading was assessed as described in Materials and Methods. (E) Western blot analysis of liver proteins from WT mice fed an SC diet or an HFD for 6 weeks. Each lane represents proteins from a different mouse. The blot was incubated with an antibody ...
http://dmd.aspetjournals.org/content/45/9/982/tab-figures-data
Dentahex Oral Rinse l Antimicrobial Oral Rinse For Pets | Medi-VetDentahex Oral Rinse l Antimicrobial Oral Rinse For Pets | Medi-Vet
Dentahex Oral Rinse is a palatable and highly effective antimicrobial oral rinse for reducing plaque and freshening breath in dogs and cats. The unique formulation provides anti-plaque and anti-calculus properties.
https://www.medi-vet.com/VET-Solutions-Dentahex-Oral-Rinse-p/10554.htm
Spry Cool Mint Natural Oral RinseSpry Cool Mint Natural Oral Rinse
With Spry Oral Rinse, it only takes 60 seconds to get fresh Cool Mint breath and a clean mouth too. Spry Oral Rinse uses xylitol, a natural sweetener that helps maintain a healthy mouth. Provide the defense our mouth deserves with Spry Oral Rinse.
http://www.xlear.com/store/spry-dental-defense/cool-mint-natural-oral-rinse.html
Recombinant Human FMO5 protein (ab57977) ReferencesRecombinant Human FMO5 protein (ab57977) References
References for Abcams Recombinant Human FMO5 protein (ab57977). Please let us know if you have used this product in your publication
http://www.abcam.com/recombinant-human-fmo5-protein-ab57977-references.html
p-Tolyl isothiocyanatep-Tolyl isothiocyanate
Move victim to fresh air. Apply artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult ...
http://www.chemicaldictionary.org/dic/P/p-Tolyl-isothiocyanate_2030.html
Citation tools | Drug Metabolism & DispositionCitation tools | Drug Metabolism & Disposition
Scott, Flora et al Identification of Flavin-Containing Monooxygenase 5 (FMO5) as a Regulator of Glucose Homeostasis and a Potential Sensor of Gut Bacteria. Drug Metabolism and Disposition 45.9 (2017): 982-989. Web. 20 Jan. 2018. ...
http://dmd.aspetjournals.org/highwire/citation/69745/download
Provisional Restorations - Denver Dentist | Downing Street DentalProvisional Restorations - Denver Dentist | Downing Street Dental
You may need to wear your temporaries for just a few days or for several months depending on the type of dental reconstruction you are undergoing. Temporaries formed in place of crowns or veneers may only need to be worn for a few days to a few weeks, whereas dental implant and full-mouth reconstruction patients will need to wear provisional restorations for several months while the gums heal and the implants fuse with surrounding bone. Keep in mind that provisional restorations are less durable than permanent ones and are placed using provisional cement. Because it is possible for them to shift or become damaged, you should be careful to follow your dentists guidelines for caring for your temporaries - including using good oral hygiene, abiding by dietary restrictions, and using protective mouth gear during sports or high impact activity.. ...
http://downingstreetdental.com/provisional-restorations/
Provisional Restorations - Southwest Family DentistryDentist in Lake City, FL - John A. Batlle, III, D.M.D. - Southwest Family...Provisional Restorations - Southwest Family DentistryDentist in Lake City, FL - John A. Batlle, III, D.M.D. - Southwest Family...
You may need to wear your temporaries for just a few days or for several months depending on the type of dental reconstruction you are undergoing. Temporaries formed in place of crowns or veneers may only need to be worn for a few days to a few weeks, whereas dental implant and full-mouth reconstruction patients will need to wear provisional restorations for several months while the gums heal and the implants fuse with surrounding bone. Keep in mind that provisional restorations are less durable than permanent ones and are placed using provisional cement. Because it is possible for them to shift or become damaged, you should be careful to follow your dentists guidelines for caring for your temporaries - including using good oral hygiene, abiding by dietary restrictions, and using protective mouth gear during sports or high impact activity.. ...
https://swfamilydentistry.com/provisional-restorations/
Provisional Restoration Ref. Journal of Esthetic ... (Example) - MindMeisterProvisional Restoration Ref. Journal of Esthetic ... (Example) - MindMeister
Provisional Restoration Ref. Journal of Esthetic and Restorative Dentistry, Feb 2012, B. Common Materials used for custom interim-fixed restorations, A. The interim treatment focuses on, Created by: SaudiDent.com, C. Success Parameters
https://www.mindmeister.com/140871584/provisional-restoration-ref-journal-of-esthetic-and-restorative-dentistry-feb-2012
A Flipper Shouldnt Be Your First Choice: Alternative Implant Provisional Restorations | The Curious DentistA Flipper Shouldnt Be Your First Choice: Alternative Implant Provisional Restorations | The Curious Dentist
Flippers serve a purpose. However you will better serve your patients if you explore the superior options for a temporary implant restoration.
http://thecuriousdentist.com/a-flipper-shouldnt-be-your-first-choice-alterative-provisionals/
Get to know a gene: UGT2B15 | GeneSightGet to know a gene: UGT2B15 | GeneSight
1. He, X. et al. Evidence for oxazepam as an in vivo probe of UGT2B15: Oxazepam clearance is reduced by UGT2B15 D85Y polymorphism but unaffected by UGT2B17 deletion. Br. J. Clin. Pharmacol. 68, 721-730 (2009).. 2. Court, M. H. et al. UDP-glucuronosyltransferase (UGT) 2B15 pharmacogenetics: UGT2B15 D85Y genotype and gender are major determinants of oxazepam glucuronidation by human liver. J. Pharmacol. Exp. Ther. 310, 656-665 (2004).. 3. Uchaipichat, V., Suthisisang, C. & Miners, J. O. The glucuronidation of R- and S-lorazepam: Human liver microsomal kinetics, UDPglucuronosyltransferase enzyme selectivity, and inhibition by drugs. Drug Metab. Dispos. 41, 1273-1284 (2013).. 4. Levesque, E., Beaulieu, M., Green, M.D., Tephly, T.R., Belanger, A., Hum, D. W. Isolation and characterization of UGT2B15(Y85): a UDPglucuronosyltransferase encoded by a polymorphic gene. Pharmacogenetics 7, 317-325 (1997).. 5. Riedy, M. et al. Genomic organization of the UGT2b gene cluster on human chromosome 4q13. ...
https://genesight.com/get-to-know-a-gene-ugt2b15/
Regional myocardial radiotracer kinetics in dogs using miniature radiation detectors<...Regional myocardial radiotracer kinetics in dogs using miniature radiation detectors<...
TY - JOUR. T1 - Regional myocardial radiotracer kinetics in dogs using miniature radiation detectors. AU - Jacobs, M. L.. AU - Okada, R. D.. AU - Daggett, W. M.. PY - 1982. Y1 - 1982. N2 - An implantable device for continous measurement of regional myocardial radioisotope activity was designed and validated. The probe consists of a 2-mm3 cadmium telluride crystal surrounded by lead foil housed in a 4,5-mm outer diameter steel cylinder. Activity in serial dilutions of thallium-201 measured by this miniature gamma detector correlated well with activity measured in the well counter (r = 0.99). In vivo probe measurements of regional myocardial thallium-201 activity in a canine model were compared with activity in punch biopsies, again with excellent correlation (r = 0.90). The crystal was mounted on a modified arterial clamp, which was inserted into the left ventricle through the apex and situated on the endocardial surface of the anterior or posterior wall. It was thus possible to measure regional ...
https://jhu.pure.elsevier.com/en/publications/regional-myocardial-radiotracer-kinetics-in-dogs-using-miniature--7
Organomolybdenum (VI) and lithium Organomolybdate (VI) and (V) Complexes with C,N-Chelating Aminoaryl LigandsOrganomolybdenum (VI) and lithium Organomolybdate (VI) and (V) Complexes with C,N-Chelating Aminoaryl Ligands
The synthesis and characterization of new, five-coordinate molybdenum bis(imidoaryl) complexes [Mo(NAr)2(C-N)X] (Ar = C6H3i-Pr2-2,6; C-N = [C6H4(CH2NMe2)-2]-; X = Cl (1), Me (2), Et (3), Bu (4), CH2SiMe3 (5), (p-tolyl) (6), (C-N) (7)) is reported. The solid-state structure of 2 has been elucidated by single-crystal X-ray analysis. Compounds 2, 3, ... read more 4, 5, and 6 react with alkyl- or aryllithium compounds to form lithium molybdate(VI) derivatives, of which [Li(DME)Mo(NAr)2(C-N)(Me)(p-tolyl)] (10), formed by the reaction of 2 with [Li(p-tolyl)], has been structurally (X-ray) characterized. Thermal activation of these lithium molybdates leads to the formation of paramagnetic lithium molybdate(V) compounds instead of the anticipated molybdenum(VI) alkylidenes. The actual temperature (between -10 and 80 C) at which paramagnetic Mo(V) radical anions are formed is dependent on both the type of alkyl or aryl substituent (introduced via LiR) and the solvent. The synthesis of [LiMo(NAr)2(C-N)2] ...
https://dspace.library.uu.nl/handle/1874/6374
CRYSTAL AND MOLECULAR-STRUCTURE OF B,B-BIS(P-TOLYL)BOROXAZOLIDINE AND ORTHORHOMBIC FORM OF B,B-DIPHENYLBOROXAZOLIDINE | UBC...CRYSTAL AND MOLECULAR-STRUCTURE OF B,B-BIS(P-TOLYL)BOROXAZOLIDINE AND ORTHORHOMBIC FORM OF B,B-DIPHENYLBOROXAZOLIDINE | UBC...
Department of Chemistry, UBC Faculty of Science. Vancouver Campus. 2036 Main Mall. Vancouver, BC Canada V6T 1Z1. Tel: 604.822.3266. Fax: 604.822.2847. ...
http://www.chem.ubc.ca/crystal-and-molecular-structure-bb-bisp-tolylboroxazolidine-and-orthorhombic-form-bb
High Rate of Head-and-Neck Cancer in Women Pinned to Smoking | Medpage TodayHigh Rate of Head-and-Neck Cancer in Women Pinned to Smoking | Medpage Today
ROCKVILLE. Md. -- Women appear to be particularly vulnerable to head-and-neck cancer from smoking, according to National Cancer Institute researchers.
https://www.medpagetoday.com/hematologyoncology/othercancers/6511
Chemoradiation Lessens Need for Surgery in Head-and-Neck Cancer | Medpage TodayChemoradiation Lessens Need for Surgery in Head-and-Neck Cancer | Medpage Today
RANCHO MIRAGE, Calif. -- Chemoradiation allows many patients with node-positive head-and-neck cancer to avoid additional surgery to the neck, a researcher reported here.
https://www.medpagetoday.com/hematologyoncology/othercancers/4910
Oral Rinse & Mouthwash | RandallsOral Rinse & Mouthwash | Randalls
Shop Oral Rinse & Mouthwash direct from Randalls. Browse our selection and order groceries for flexible Delivery or convenient Drive Up and Go to fit your schedule.
https://www.randalls.com/shop/aisles/personal-care-health/oral-hygiene/oral-rinse-mouthwash.1066.html
TheraBreath Oral Rinse 1-Liter | TheraBreathTheraBreath Oral Rinse 1-Liter | TheraBreath
TheraBreaths clinically proven, mild mint flavored oral rinse uses the oxygenating power of OXYD-8 to kill the bacteria that cause bad breath. New 1-liter bottle!
https://www.therabreath.com/mouthwash/therabreath-oral-rinse-liter/
RCSB PDB - Protein Feature View - Putative flavin-containing monooxygenase - Q83XK4 (Q83XK4 9GAMM)RCSB PDB - Protein Feature View - Putative flavin-containing monooxygenase - Q83XK4 (Q83XK4 9GAMM)
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
http://www.rcsb.org/pdb/protein/Q83XK4
Fmo1 - Dimethylaniline monooxygenase [N-oxide-forming] 1 - Mus musculus (Mouse) - Fmo1 gene & proteinFmo1 - Dimethylaniline monooxygenase [N-oxide-forming] 1 - Mus musculus (Mouse) - Fmo1 gene & protein
This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines.
http://www.uniprot.org/uniprot/P50285
How to Get What You Want in Your Smile Makeover - Dyer Family DentistryHow to Get What You Want in Your Smile Makeover - Dyer Family Dentistry
Your makeover is more likely to meet your expectations if you get an advanced view of the results. Computer imaging is one way to do this. Another is for us to make a mock-up of the proposed dental work in tooth-colored wax on models of your mouth.. Finally, a Provisional Restoration can be used as a test to make sure that what I envision is also what you, the patient, want to see. A provisional restoration, made from temporary materials, gives you a chance to test out the changes and make sure they work for you - that they not only look good, but they are also functional in terms of biting, chewing, speech, and gum health.. If the provisional restoration works, it is used as a blueprint to make durable and long lasting porcelains in the same design. We will take impressions of the provisional restoration and communicate the relevant information to a dental laboratory technician, who will make the final porcelain tooth replicas for your new smile.. Competent communication and a provisional ...
http://www.dyerfamilydental.com/blog/post/how-to-get-what-you-want-in-your-smile-makeover.html
Amine oxidase flavin-containing | definition of amine oxidase flavin-containing by Medical dictionaryAmine oxidase flavin-containing | definition of amine oxidase flavin-containing by Medical dictionary
Looking for online definition of amine oxidase flavin-containing in the Medical Dictionary? amine oxidase flavin-containing explanation free. What is amine oxidase flavin-containing? Meaning of amine oxidase flavin-containing medical term. What does amine oxidase flavin-containing mean?
https://medical-dictionary.thefreedictionary.com/amine+oxidase+flavin-containing
Provisionalization Using Bis-Acrylate and Polyvinylsiloxane Matrix : The Next DDSProvisionalization Using Bis-Acrylate and Polyvinylsiloxane Matrix : The Next DDS
Provisionalization is a necessary stage in the prosthetic restoration of the majority of patients that require tooth reduction during aesthetic enhancement. Through this process, the members of the treatment team are able to evaluate and perform aesthetic, phonetic, and functional adjustments to the provisional restoration while simultaneously preserving or enhancing the state of the dental and gingival tissues during the fabrication of the definitive prosthesis.1,2 Although provisionalization can be performed in numerous manners that include acrylic resin,3 the sandwich technique,1 direct composite bonding,2,4 and laboratory-fabricated provisional veneers,4 these techniques are often inefficient based upon the handling properties of the provisional material, the durability of the provisional restoration, or the expenses involved. These procedures may be complicated by the duration or difficulty of the chairside fabrication process as well. Provisional materials also exhibit a tendency to lose ...
http://thenextdds.com/Case-Studies/Provisionalization-Using-Bis-Acrylate-and-Polyvinylsiloxane-Matrix/
Absence of metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) by flavin-containing monooxygenase (FMO). :...Absence of metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) by flavin-containing monooxygenase (FMO). :...
The N-nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a potent lung carcinogen present in tobacco and tobacco smoke. Carbonyl reduction, alpha-carbon hydroxylation (activation) and N-oxidation of the pyridyl ring (detoxification) are the three main pathways of metabolism of NNK. In this study, metabolism of NNK was studied with lung and liver microsomes from F344 rats, Syrian golden hamsters and pigs and cloned flavin-containing monooxygenases (FMOs) from human and rabbit liver. Thermal inactivation at 45 degrees C for 2 min reduced FMO S-oxygenating activity but did not affect N-oxidation of NNK, leading to the conclusion that FMOs are not implicated in the detoxification of NNK. Detoxification of NNK was not increased by n-octylamine or by incubation at pH 8.4, supporting the conclusion that FMOs are not involved in the metabolism of NNK. SKF-525A (1 mM) significantly reduced N-oxidation and alpha-carbon hydroxylation, suggesting that these two pathways were catalyzed by ...
http://oxfordindex.oup.com/view/10.1093/carcin/18.10.1979
Ray, Innovation in ImagingRay, Innovation in Imaging
Discover the latest dental CT, pano, ceph, X-ray, sensor, scanner, biocompatible UV resin and 3D printer for provisional restoration, orthodontic and model.
http://www.raymedical.com.hk/tag/clinical-case/
Dry Mouth Gentle Oral Rinse (Mouthwash) | Biotène®Dry Mouth Gentle Oral Rinse (Mouthwash) | Biotène®
Biotène® Gentle Oral Rinse is specially formulated for Dry Mouth prone to irritation. Discover how our oral rinse can help soothe, clean, and relieve your Dry Mouth symptoms.
https://www.biotene.com/dry-mouth-products/gentle-oral-rinse/
Biotene Dry Mouth Oral Rinse | WalgreensBiotene Dry Mouth Oral Rinse | Walgreens
Biotene Dry Mouth Oral Rinse at Walgreens. Get free shipping at $35 and view promotions and reviews for Biotene Dry Mouth Oral Rinse
https://www.walgreens.com/store/c/biotene-dry-mouth-oral-rinse/ID=prod3212444-product
Peridex Oral Rinse 0.12% (RX), 4 Fluid Ounce, Zila Pharmaceuticals Inc. Ingredients and ReviewsPeridex Oral Rinse 0.12% (RX), 4 Fluid Ounce, Zila Pharmaceuticals Inc. Ingredients and Reviews
Ingredients reviewed for Peridex Oral Rinse 0.12% (RX) to be hypoallergenic and free of Fragrance, Gluten, Coconut, Nickel, Preservatives, Lanolin, and MCI/MI
https://www.skinsafeproducts.com/peridex-oral-rinse-0-12-rx-4-fluid-ounce-zila-pharmaceuticals-inc
Plus itPlus it
We have demonstrated that volume of the head and body of the caudate nucleus differs significantly and substantially (ranging from 93% to 75% of control caudate volumes) in subtypes of FTLD. We also found that caudate nucleus volume was correlated with cognition measured via MMSE score, with lower volume correlating with poorer cognition. This finding complements previous meta-analyses showing functional and structural change in the caudate within subtypes of FTLD as well as in cortical regions.1. Krishnamoorthy30 has postulated that increase in volume of brain structures associated with emotion, such as the amygdala, may reflect either a predilection for emotional reactivity or plasticity and growth of the structure due to hyperactivity. The corollary is that neurodegenerative processes may result in atrophy and underactivity of the structure. Therefore, the caudate may be reduced in volume due to underactivity and/or degeneration as part of the FTLD process. That smaller caudate nucleus volume ...
http://www.ajnr.org/content/29/8/1537
Percutaneous Absorption of UV Filters Contained in | Zacarías León González | SpringerPercutaneous Absorption of UV Filters Contained in | Zacarías León González | Springer
Nominated as an outstanding Ph.D. thesis by the University of Valencia, Spain Presents a comprehensive review of the literature Provides detailed
http://www.springer.com/us/book/9783319011882
AnalgesicAnalgesic
Benzydamine. Comes in free acid form; freely soluble in water.. As per diclofenac.. Topical, PO, rectal, spray and vaginal.. No ...
https://en.wikipedia.org/wiki/Algesic
Mouth ulcerMouth ulcer
A topical analgesic (e.g. benzydamine mouthwash) may reduce pain. Topical (gels, creams or inhalers) or systemic steroids may ...
https://en.wikipedia.org/wiki/Mouth_ulcer
Curtius rearrangementCurtius rearrangement
... benzydamine, gabapentin, igmesine and tecadenoson. R. B. Woodward et al. used the Curtius rearrangement as one of the steps in ...
https://en.wikipedia.org/wiki/Curtius_rearrangement
Nonsteroidal anti-inflammatory drugNonsteroidal anti-inflammatory drug
... and benzydamine.[medical citation needed] Benoxaprofen, since withdrawn due to its liver toxicity, was the most photoactive ...
https://en.wikipedia.org/wiki/Nonsteroidal_anti-inflammatory_drug
ATC code M01ATC code M01
QM01AH95 Enflicoxib M01AX01 Nabumetone M01AX02 Niflumic acid M01AX04 Azapropazone M01AX05 Glucosamine M01AX07 Benzydamine ...
https://en.wikipedia.org/wiki/ATC_code_M01
List of MeSH codes (D03)List of MeSH codes (D03)
... benzydamine MeSH D03.438.449.350 - granisetron MeSH D03.438.473.025 - adrenochrome MeSH D03.438.473.050 - alcian blue MeSH ... benzydamine MeSH D03.383.129.539.487.350 - granisetron MeSH D03.383.129.539.550 - muzolimine MeSH D03.383.129.539.650 - ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D03)
ATC code A01ATC code A01
... combinations A01AD01 Epinephrine A01AD02 Benzydamine A01AD05 Acetylsalicylic acid A01AD06 Adrenalone A01AD07 Amlexanox A01AD08 ...
https://en.wikipedia.org/wiki/ATC_code_A01
AB-FUBINACAAB-FUBINACA
ADB 5F-AMB 5F-APINACA AB-CHFUPYCA AB-CHMINACA AB-PINACA ADB-CHMINACA ADB-FUBINACA ADBICA AMB-FUBINACA APICA APINACA Benzydamine ...
https://en.wikipedia.org/wiki/AB-FUBINACA
ATC code R02ATC code R02
Benzocaine R02AD02 Lidocaine R02AD03 Cocaine R02AD04 Dyclonine R02AX01 Flurbiprofen R02AX02 Ibuprofen R02AX03 Benzydamine "ATC ...
https://en.wikipedia.org/wiki/ATC_code_R02
MouthwashMouthwash
In painful oral conditions such as aphthous stomatitis, analgesic mouthrinses (e.g. benzydamine mouthwash, or "Difflam") are ...
https://en.wikipedia.org/wiki/Mouthwash
ATC code M02ATC code M02
M02AA01 Phenylbutazone M02AA02 Mofebutazone M02AA03 Clofezone M02AA04 Oxyphenbutazone M02AA05 Benzydamine M02AA06 Etofenamate ...
https://en.wikipedia.org/wiki/ATC_code_M02
List of drugs: BeList of drugs: Be
Benzydamine (INN) Benzyl Benzoate Benzylpenicillin (INN) Benzylsulfamide (INN) Bepadin Bepafant (INN) Beperidium iodide (INN) ...
https://en.wikipedia.org/wiki/List_of_drugs:_Be
ATC code G02ATC code G02
Cabergoline G02CB04 Quinagolide G02CB05 Metergoline G02CB06 Terguride G02CC01 Ibuprofen G02CC02 Naproxen G02CC03 Benzydamine ...
https://en.wikipedia.org/wiki/ATC_code_G02
C19H23N3OC19H23N3O
The molecular formula C19H23N3O (molar mass: 309.40 g/mol, exact mass: 309.1841 u) may refer to: A-412,997 Benzydamine This set ...
https://en.wikipedia.org/wiki/C19H23N3O
BenzydamineBenzydamine
"Benzydamine oral rinse". Medicinenet. "Difflam spray (benzydamine)". Net Doctor, UK. "Tantum Verde (benzydamine)". Carysfort ... There are no contraindications to the use of benzydamine except for known hypersensitivity. Benzydamine is well tolerated. ... Fanaki NH, El-Nakeeb MA (March 1996). "Antibacterial activity of benzydamine and antibiotic-benzydamine combinations against ... Benzydamine is poorly absorbed through skin and vagina. Synthesis starts with the reaction of the N-benzyl derivative from ...
https://en.wikipedia.org/wiki/Benzydamine
FesoterodineFesoterodine
InChI=1S/C26H37NO3/c1-18(2)26(29)30-25-13-12-21(17-28)16-24(25)23(22-10-8-7-9-11-22)14-15-27(19(3)4)20(5)6/h7-13,16,18-20,23,28H,14-15,17H2,1-6H3/t23-/m1/s1 ...
https://en.wikipedia.org/wiki/Fesoterodine
YohimbineYohimbine
In the US, "yohimbe" preparations are sold as a dietary supplements for enhancing libido, for weight loss and as aids for bodybuilding; but "There is virtually no published research on yohimbe which supports these or any other claims".[9]:861 Often, these products explicitly claim to contain yohimbine.[8] Cohen et al. found that samples of brands sold in American brick-and-mortar stores contained highly variable amounts of yohimbine, and sometimes none at all.[8]:368 Labelling claims were often misleading.[8]:368 Similar results have been reported by other laboratories for products sold in the U.S., in other countries and on the internet.[15][16][17][18][19] One study found that many brands of "yohimbe" might not derive from the P. johimbe tree in the first place.[20] According to yet another source the yohimbe sold in markets in West Africa, where the tree grows, is frequently adulterated with other species of the genus Pausinystalia; these contain little yohimbine.[21] The amounts of alkaloid ...
https://en.wikipedia.org/wiki/Yohimbine
A-366,833A-366,833
Ji, Jianguo; Bunnelle, William H.; Anderson, David J.; Faltynek, Connie; Dyhring, Tino; Ahring, Philip K.; Rueter, Lynne E.; Curzon, Peter; Buckley, Michael J.; Marsh, Kennan C.; Kempf-Grote, Anita; Meyer, Michael D. (2007). "A-366833: A novel nicotinonitrile-substituted 3,6-diazabicyclo[3.2.0]-heptane α4β2 nicotinic acetylcholine receptor selective agonist: Synthesis, analgesic efficacy and tolerability profile in animal models". Biochemical Pharmacology. 74 (8): 1253-1262. doi:10.1016/j.bcp.2007.08.010. PMID 17854775 ...
https://en.wikipedia.org/wiki/A-366,833
MethanthelineMethantheline
The topic of this article may not meet Wikipedia's general notability guideline. Please help to establish notability by citing reliable secondary sources that are independent of the topic and provide significant coverage of it beyond a mere trivial mention. If notability cannot be established, the article is likely to be merged, redirected, or deleted ...
https://en.wikipedia.org/wiki/Methantheline
4-Benzylpiperidine4-Benzylpiperidine
... is a drug and research chemical used in scientific studies. It acts as a monoamine releasing agent with 20- to 48-fold selectivity for releasing dopamine versus serotonin. It is most efficacious as a releaser of norepinephrine, with an ec50 of 109/41.4/5246nM for DA/NE/5HT, respectively .[1] It has a fast onset of action and a short duration.[1] It also functions as a monoamine oxidase inhibitor (MAOI) with preference for MAO-A.[2] ...
https://en.wikipedia.org/wiki/4-Benzylpiperidine
RTI-229RTI-229
... , also known as (-)-3β-(4-iodophenyl)tropane-2β-pyrrolidine carboxamide and RTI-4229-229, is a potent and long-lasting stimulant drug which was developed in the 1990s as part of a large group of related analogues from the phenyltropane family. With the combination of two potent dopamine transporter (DAT) binding motifs attached to the tropane ring, the p-iodophenyl group at the 3β-position and a pyrrolidine carboxamide at 2β, RTI-229 has extremely high selectivity for the dopamine transporter (2600x and 4600x selective over NET and 5-HTT respectively) and is one of the most DAT-selective compounds in the RTI series.[1][2] ...
https://en.wikipedia.org/wiki/RTI-229
ErgolineErgoline
There are a variety of clinically useful ergoline derivatives for the purpose of vasoconstriction, the treatment of migraines, and treatment of Parkinson's disease. Ergoline alkaloids found their place in pharmacology long before modern medicine as preparations of ergot were often used by midwives in the 12th century to stimulate childbirth.[10] Following Arthur Stoll's isolation of ergometrine, the therapeutic use of ergoline derivatives became well explored. The induction of uterine contractions via the preparation of ergot was attributed to ergonovine, an ergoline derivative found in ergot, which is a powerful oxytocic. From this, methergine, a synthetic derivative, was elucidated.[7] While used to facilitate child birth, ergoline derivatives can pass into breast milk and should not be used during breastfeeding.[11] They are uterine contractors that can increase the risk of miscarriage during pregnancy.[3] Another example of medically relevant ergoline alkaloids is ergotamine, an alkaloid ...
https://en.wikipedia.org/wiki/Ergoline
Clidinium bromideClidinium bromide
Used in fixed combination with chlordiazepoxide as adjunctive therapy in the treatment of peptic ulcer disease; however, no conclusive data that antimuscarinics aid in the healing, decrease the rate of recurrence, or prevent complications of peptic ulcers.[2] With the advent of more effective therapies for the treatment of peptic ulcer disease, antimuscarinics have only limited usefulness in this condition. ...
https://en.wikipedia.org/wiki/Clidinium_bromide
Fenamic acidFenamic acid
... is an organic compound, which, especially in its ester form, is called fenamate.[1]:458 serves as a parent structure for several nonsteroidal anti-inflammatory drugs (NSAIDs), including mefenamic acid, tolfenamic acid, flufenamic acid, and meclofenamic acid. These drugs are commonly referred to as "anthranilic acid derivatives" or "fenamates" because fenamic acid is a derivative of anthranilic acid.[2]:235[3]:17[2] ...
https://en.wikipedia.org/wiki/Fenamic_acid
BenorilateBenorilate
... (INN), or benorylate, is an ester-linked codrug of aspirin with paracetamol. It is used as an anti-inflammatory and antipyretic medication. In the treatment of childhood fever, it has been shown to be inferior to paracetamol and aspirin taken separately. In addition, because it is converted to aspirin, benorylate is not recommended in children due to concerns about Reye syndrome.[1] ...
https://en.wikipedia.org/wiki/Benorilate
RofecoxibRofecoxib
The VIGOR (Vioxx GI Outcomes Research) study, conducted by Bombardier, et al., which compared the efficacy and adverse effect profiles of rofecoxib and naproxen, had indicated a significant 4-fold increased risk of acute myocardial infarction (heart attack) in rofecoxib patients when compared with naproxen patients (0.4% vs 0.1%, RR 0.25) over the 12-month span of the study. The elevated risk began during the second month on rofecoxib. There was no significant difference in the mortality from cardiovascular events between the two groups, nor was there any significant difference in the rate of myocardial infarction between the rofecoxib and naproxen treatment groups in patients without high cardiovascular risk. The difference in overall risk was by the patients at higher risk of heart attack, i.e. those meeting the criteria for low-dose aspirin prophylaxis of secondary cardiovascular events (previous myocardial infarction, angina, cerebrovascular accident, transient ischemic attack, or coronary ...
https://en.wikipedia.org/wiki/Rofecoxib
AspirinAspirin
Acetylsalicylic acid is a weak acid, and very little of it is ionized in the stomach after oral administration. Acetylsalicylic acid is quickly absorbed through the cell membrane in the acidic conditions of the stomach. The increased pH and larger surface area of the small intestine causes aspirin to be absorbed more slowly there, as more of it is ionised. Owing to the formation of concretions, aspirin is absorbed much more slowly during overdose, and plasma concentrations can continue to rise for up to 24 hours after ingestion.[152][153][154] About 50-80% of salicylate in the blood is bound to albumin protein, while the rest remains in the active, ionized state; protein binding is concentration-dependent. Saturation of binding sites leads to more free salicylate and increased toxicity. The volume of distribution is 0.1-0.2 L/kg. Acidosis increases the volume of distribution because of enhancement of tissue penetration of salicylates.[154] As much as 80% of therapeutic doses of salicylic acid is ...
https://en.wikipedia.org/wiki/Acetylsalicylic_acid
MuscarineMuscarine
... poisoning is characterized by miosis, blurred vision, increased salivation, excessive sweating, lacrimation, bronchial secretions, bronchoconstriction, bradycardia, abdominal cramping, increased gastric acid secretion, diarrhea and polyuria. If muscarine reaches the brain it can cause tremor, convulsions and hypothermia. Cardiac ventricles contain muscarinic receptors that mediate a decrease in the force of contractions leading to a lower blood pressure. If muscarine is administered intravenously, muscarine can trigger acute circulatory failure with cardiac arrest.[1] The symptoms of intoxication with mushrooms rich in muscarine, especially Inocybe, are very typical: The symptoms start early, after one-quarter to two hours, with headache, nausea, vomiting, and constriction of the pharynx. Then salivation, lacrimation, and diffuse perspiration set in, combined with miosis, disturbed accommodation, and reduced vision. Gastric and small bowel colic leads to diarrhea, and there is a ...
https://en.wikipedia.org/wiki/Muscarine
EugeroicEugeroic
... s (originally, "eugrégorique" or "eugregoric"),[1] also known as wakefulness-promoting agents and wakefulness-promoting drugs, are a class of drugs that promote wakefulness and alertness.[2][3] They are medically indicated for the treatment of certain sleep disorders including excessive daytime sleepiness (EDS) in narcolepsy or obstructive sleep apnea (OSA).[2][3] They generally have a very low addictive potential.[2][3] Eugeroics are also often prescribed off-label for the treatment of EDS in idiopathic hypersomnia,[4] a rare and often debilitating sleep disorder which currently has no official treatments approved by the Food and Drug Administration (FDA). Modafinil and armodafinil each act as a selective, weak, atypical dopamine reuptake inhibitor (DRI)[2][3] whereas adrafinil acts as a prodrug for modafinil. Other eugeroics include solriamfetol, which acts as a norepinephrine-dopamine reuptake inhibitor (NDRI), and pitolisant, which acts as a histamine 3 (H₃) receptor ...
https://en.wikipedia.org/wiki/Eugeroic
NaphyroneNaphyrone
... emerged as a new legal high in the United Kingdom only months after the ban of similar drug mephedrone (which was also a cathinone derivative). Until July 2010 the substance was not controlled by the Misuse of Drugs Act 1971 and was therefore not illegal for someone to possess. The Medicines Act prevented naphyrone from being sold for human consumption, and therefore it was sometimes sold as 'pond cleaner' or as another substance not normally consumed by humans. In response to this emerging trend of new designer drugs, Home Office Minister James Brokenshire said, "action to address the issue of emerging legal highs coming on to the market is a priority for the government."[12][unreliable source?] A study by researchers at Liverpool John Moores University found that only one out of ten products labelled as "NRG-1" actually contained naphyrone when they were subjected to laboratory analysis. Compounds found in products labelled NRG-1 included MDPV, flephedrone, mephedrone, butylone and ...
https://en.wikipedia.org/wiki/Naphyrone
Benzydamine - WikipediaBenzydamine - Wikipedia
"Benzydamine oral rinse". Medicinenet. "Difflam spray (benzydamine)". Net Doctor, UK. "Tantum Verde (benzydamine)". Carysfort ... There are no contraindications to the use of benzydamine except for known hypersensitivity. Benzydamine is well tolerated. ... Fanaki NH, El-Nakeeb MA (March 1996). "Antibacterial activity of benzydamine and antibiotic-benzydamine combinations against ... Benzydamine is poorly absorbed through skin and vagina. Synthesis starts with the reaction of the N-benzyl derivative from ...
https://en.wikipedia.org/wiki/Benzydamine
Difflam spray (benzydamine): how does it work?Difflam spray (benzydamine): how does it work?
Benzydamine reduces inflammation and pain in the area itss applied to.. Benzydamine also acts as a mild local anaesthetic, ... Difflam spray contains benzydamine, which is a non-steroidal anti-inflammatory drug (NSAID), it acts as an analgesic and anti- ... Difflam spray contains benzydamine hydrochloride, which works by stopping the production of various chemicals in the body that ...
https://www.netdoctor.co.uk/medicines/aches-pains/a8001/difflam-spray-benzydamine/
Lymphomatoid photocontact dermatitis to benzydamine hydrochloride. | Sigma-AldrichLymphomatoid photocontact dermatitis to benzydamine hydrochloride. | Sigma-Aldrich
Benzydamine hydrochloride, analytical standard C19H23N3O · HCl ...
https://www.sigmaaldrich.com/catalog/papers/20136895
Benzydamine HCl for Postoperative Sore Throat - Full Text View - ClinicalTrials.govBenzydamine HCl for Postoperative Sore Throat - Full Text View - ClinicalTrials.gov
Drug: benzydamine HCl 3 ml (4.5 mg) of benzydamine hydrochloride will be dripped on the cuff of the endotracheal tube 5 minutes ... Experimental: benzydamine HCl benzydamine HCl will be dripped on the cuff of the endotracheal tube 5 minutes before induction ... Benzydamine HCl for Postoperative Sore Throat (POST). The safety and scientific validity of this study is the responsibility of ... side effects of benzydamine hydrochloride [ Time Frame: 24 hours ]. the incidence of throat numbness, throat burning sensation ...
https://clinicaltrials.gov/ct2/show/NCT01637883?recr=Open&cond=%22Pharyngitis%22&rank=11
Actifedrin Lozenges (Benzydamine Hydrochloride) Investi FarmaActifedrin Lozenges (Benzydamine Hydrochloride) Investi Farma
Actifedrin Lozenges information about active ingredients, pharmaceutical forms and doses by Investi Farma, Actifedrin Lozenges indications, usages and related health products lists
http://drugs-about.com/drugs-a/actifedrin-lozenges.html
Difflam-C (Benzydamine Hydrochloride; Chlorhexidine Gluconate) 3MDifflam-C (Benzydamine Hydrochloride; Chlorhexidine Gluconate) 3M
A01AD02 - Benzydamine*D08AC52 - Chlorhexidine, combinations. Pharmaceutical companies: manufacturers, researchers, developers, ...
https://drugs-about.com/drugs-d/difflam-c.html
Benzydamine N-oxide | C19H23N3O2 - PubChemBenzydamine N-oxide | C19H23N3O2 - PubChem
Benzydamine N-oxide , C19H23N3O2 , CID 65465 - structure, chemical names, physical and chemical properties, classification, ...
https://pubchem.ncbi.nlm.nih.gov/compound/65465
Dom-Benzydamine - Uses, Side Effects, Interactions - Canada.comDom-Benzydamine - Uses, Side Effects, Interactions - Canada.com
Benzydamine liquid is used to relieve the pain and inflammation associated with a sore throat or with mouth sores caused by ... Benzydamine liquid is used to relieve the pain and inflammation associated with a sore throat or with mouth sores caused by ... Do not use this medication if you are allergic to benzydamine or any ingredients of the medication. ... Benzydamine liquid is used as a mouth rinse or gargle to soothe sore areas in the mouth or throat. It should not be swallowed. ...
https://bodyandhealth.canada.com/drug/getdrug/dom-benzydamine
Benzydamine for Radiation-Related Mucositis | ONSBenzydamine for Radiation-Related Mucositis | ONS
Benzydamine has been evaluated in patients with cancer for the prevention and management of mucositis. ... Benzydamine is a nonsteroidal anti-inflammatory drug that has been used in an oral rinse. It has some local anesthetic and ... Benzydamine for Radiation-Related Mucositis. for Mucositis. Benzydamine is a nonsteroidal anti-inflammatory drug that has been ... Findings related to benzydamine were inconsistent. In a trial of chlorhexidine versus benzydamine, patients reported more ...
https://www.ons.org/node/1571?topic=1191
lidocaine (lignocaine) + benzydamine + dichlorobenzyl alcohol | healthdirectlidocaine (lignocaine) + benzydamine + dichlorobenzyl alcohol | healthdirect
... benzydamine + dichlorobenzyl alcohol including side effects, age restrictions, food interactions, whether the medicine is ... Medicines that contain lidocaine (lignocaine) + benzydamine + dichlorobenzyl alcohol *Difflam Anaesthetic, Antibacterial and ... Active ingredient: lidocaine (lignocaine) + benzydamine + dichlorobenzyl alcohol. The medicines below all contain the following ... active ingredient(s): lidocaine (lignocaine) + benzydamine + dichlorobenzyl alcohol. You can select a medicine from this list ...
https://www.healthdirect.gov.au/medicines/medicinal-product/aht,23547/lidocaine-lignocaine-benzydamine-dichlorobenzyl-alcohol
Benzydamine: Indication, Dosage, Side Effect, Precaution | MIMS IndonesiaBenzydamine: Indication, Dosage, Side Effect, Precaution | MIMS Indonesia
Benzydamine: Belongs to the class of other throat preparations., Belongs to the class of non-steroidal antiinflammatory ... R02AX03 - benzydamine ; Belongs to the class of other throat preparations. M02AA05 - benzydamine ; Belongs to the class of non- ... Description: Benzydamine inhibits the synthesis of proinflammatory cytokines including tumour necrosis factor-α (TNF-α) and ... M01AX07 - benzydamine ; Belongs to the class of other non-steroidal antiinflammatory and antirheumatic products. ...
https://www.mims.com/indonesia/drug/info/benzydamine?mtype=generic
Drug - Tantum Vag Douche 500mg/1Sachet - 1 Sachet (Benzydamine) Price List or Cost of Medication | MedindiaDrug - Tantum Vag Douche 500mg/1Sachet - 1 Sachet (Benzydamine) Price List or Cost of Medication | Medindia
Benzydamine) drug information. Find its price or cost, dose, when to use, how to use, side effects, adverse effects, ... Drug Name : Benzydamine. Benzydamine(Amigdazol Nf) generic Tantum Vag Douche is a locally-acting non-steroidal anti- ... Pms-Benzydamine, Ratio-Benzydamine, Rosalgin Pronto, Rosalgin, Sandival, Saniflor, Septolux, Tanflex, Tantum Bucal, Tantum ... Other Trade Names for Benzydamine. India : Zigat-D (3%/0.1%) , Dexasone DPS (0.1%/0.5%) , Daksone (8mg) , Dexona (0.5mg) , ...
https://www.medindia.net/drug-price/benzydamine/tantum-vag-douche.htm
Safety & Efficacy Study of Benzydamine Oral Rinse for the Treatment of Oral Mucositis (Mouth Sores) Resulting From Radiation...Safety & Efficacy Study of Benzydamine Oral Rinse for the Treatment of Oral Mucositis (Mouth Sores) Resulting From Radiation...
Patients receiving benzydamine hydrochloride 0.15% or vehicle double-blind oral rinses will place 15 mL in the mouth for 2 ... Known hypersensitivity to benzydamine HCl and/or any of the other components including alcohol, menthol, glycerin, flavoring ... The purpose of this study is to compare the effectiveness and safety of benzydamine hydrochloride 0.15% oral rinse to a vehicle ... The hypotheses are that benzydamine hydrochloride 0.15% oral rinse is better than vehicle oral rinse as measured by the ...
https://clinicaltrials.gov/ct2/show/record/NCT00051441
The effect of benzydamine hydrochloride on preventing postoperative sore throat after total thyroidectomy: a randomized...The effect of benzydamine hydrochloride on preventing postoperative sore throat after total thyroidectomy: a randomized...
We compared the effects of benzydamine hydrochloride (BH), 10% lidocaine, and normal saline spray on preventing postoperative ... Table 2 Incidence of postoperative sore throat in control (C), lidocaine (L) and benzydamine hydrochloride (B) groups. Full ... Benzydamine hydrochloride (BH) is a well-known topical non-steroidal anti-inflammatory drug (NSAID)8 that effectively reduces ... Kim, D., Jeong, H., Kwon, J. et al. The effect of benzydamine hydrochloride on preventing postoperative sore throat after total ...
https://link.springer.com/article/10.1007/s12630-019-01371-2?error=cookies_not_supported&code=9f3dc26b-fa00-4288-9e10-d72118da5bed
PRIME PubMed | Benzydamine for prophylaxis of radiation-induced oral mucositis in head and neck cancers: a double-blind placebo...PRIME PubMed | Benzydamine for prophylaxis of radiation-induced oral mucositis in head and neck cancers: a double-blind placebo...
Benzydamine for prophylaxis of radiation-induced oral mucositis in head and neck cancers: a double-blind placebo-controlled ... AdolescentAdultAgedAged, 80 and overAnti-Inflammatory AgentsBenzydamineChildDouble-Blind MethodFemaleHead and Neck Neoplasms ... 2 mucositis was 24 days in the placebo group and 28 days in the benzydamine group (P = 0.12). Benzydamine oral rinse seems to ... 2 mucositis was 24 days in the placebo group and 28 days in the benzydamine group (P = 0.12). Benzydamine oral rinse seems to ...
https://www.unboundmedicine.com/medline/citation/19267733/Benzydamine_for_prophylaxis_of_radiation_induced_oral_mucositis_in_head_and_neck_cancers:_a_double_blind_placebo_controlled_randomized_clinical_trial_
Marmoset Flavin-Containing Monooxygenase 3 in the Liver Is a Major Benzydamine and Sulindac Sulfide Oxygenase | Drug Metabolism...Marmoset Flavin-Containing Monooxygenase 3 in the Liver Is a Major Benzydamine and Sulindac Sulfide Oxygenase | Drug Metabolism...
Marmoset Flavin-Containing Monooxygenase 3 in the Liver Is a Major Benzydamine and Sulindac Sulfide Oxygenase. Shotaro Uehara, ... Marmoset Flavin-Containing Monooxygenase 3 in the Liver Is a Major Benzydamine and Sulindac Sulfide Oxygenase ...
http://dmd.aspetjournals.org/content/45/5/497.full
BENZYDAMINEBENZYDAMINE
... (benzydamine hydrochloride, PHARIXIA®) is a benzyl-indazole having analgesic, antipyretic, and anti-inflammatory ... When the cells were treated simultaneously with benzydamine and the cytokines IL-1beta or TNF-alpha, the agent benzydamine ... Benzydamine Created by admin. on Tue Mar 06 11:57:00 UTC 2018. , Edited by admin. on Tue Mar 06 11:57:00 UTC 2018. ... Furthermore, benzydamine reduced (P < 0.05) both the basal level and the cytokine-induced 3H-arachidonic acid release in ...
https://drugs.ncats.io/drug/4O21U048EF
Benzydamine - PsychonautWikiBenzydamine - PsychonautWiki
Benzydamine (also known as Difflam or Tantum Verde) is a topical anaesthetic of the indazole chemical class. It is sometimes ... Benzydamine (Reddit). References. *↑ 1.0 1.1 Recreational abuse with benzydamine hydrochloride (tantum rosa) (PubMed.gov / NCBI ... Benzydamine, or 3-(1-benzylindazol-3-yl)oxy-N,N-dimethylpropan-1-amine, is a synthetic benzyl-indazole molecule. Benzydamine ... Benzydamine (also known as Difflam or Tantum Verde) is a topical anaesthetic of the indazole chemical class. It is sometimes ...
https://psychonautwiki.org/wiki/Tantum_Verde
Benzydamine - WikipediaBenzydamine - Wikipedia
"Diffwam spray (benzydamine)". Net Doctor, UK.. *. "Tantum Verde (benzydamine)". Carysfort Heawdcare Limited, Irewand. Archived ... Fanaki NH, Ew-Nakeeb MA (March 1996). "Antibacteriaw activity of benzydamine and antibiotic-benzydamine combinations against ... Benzydamine has been used recreationawwy. In overdosages it acts as a dewiriant and CNS stimuwant.[4] Such use, particuwarwy ... Studies indicate dat benzydamine has notabwe in vitro antibacteriaw activity and awso shows synergism in combination wif oder ...
http://wikien4.appspot.com/wiki/Benzydamine
benzydamine + chlorhexidine | healthdirectbenzydamine + chlorhexidine | healthdirect
More information is available on benzydamine + chlorhexidine including side effects, age restrictions, food interactions, ... Active ingredient: benzydamine + chlorhexidine. The medicines below all contain the following active ingredient(s): benzydamine ...
https://www.healthdirect.gov.au/medicines/medicinal-product/aht,23187/benzydamine-chlorhexidine
Farhex - Drugs.comFarhex - Drugs.com
Benzydamine. Benzydamine hydrochloride (a derivative of Benzydamine) is reported as an ingredient of Farhex in the following ...
https://www.drugs.com/international/farhex.html
Home Remedies for Sore ThroatHome Remedies for Sore Throat
Benzydamine. This medication is a locally-acting non-steroidal anti-inflammatory drug, prescribed for painful musculoskeletal ...
http://www.medindia.net/homeremedies/sorethroat.asp
Recreational use of benzydamine as a hallucinogen among street youth in Brazil | Rev. bras. psiquiatr;31(3): 208-213, Sept....Recreational use of benzydamine as a hallucinogen among street youth in Brazil | Rev. bras. psiquiatr;31(3): 208-213, Sept....
... and effects of benzydamine through the use of a questionnaire. RESULTS:. 78 reported lifetime recreational benzydamine use (67 ... Full text: Available Index: LILACS (Americas) Main subject: Benzydamine / Illicit Drugs / Homeless Youth / Substance-Related ... Full text: Available Index: LILACS (Americas) Main subject: Benzydamine / Illicit Drugs / Homeless Youth / Substance-Related ... To describe the recreational use of benzydamine, an anti-inflammatory drug, among street youth in Brazil. METHOD:. Design:. a ...
https://search.bvsalud.org/gim/resource/en/lil-526259
Dental Care Products - Benzydamine Hcl 0.15% Mouth Wash Wholesale Trader from ChandigarhDental Care Products - Benzydamine Hcl 0.15% Mouth Wash Wholesale Trader from Chandigarh
Benzydamine Hcl 0.15% Mouth Wash, Potassium Nitrate Medicated Foaming Toothpaste, Chlorhexidine Gluconate Sodium Fluoride Zinc ... Benzydamine liquid is used to relieve the pain and inflammation associated with a sore throat or with mouth sores caused by ...
https://www.rechelist.com/dental-care-products.html
Analgesic - WikipediaAnalgesic - Wikipedia
Benzydamine. Comes in free acid form; freely soluble in water.. As per diclofenac.. Topical, PO, rectal, spray and vaginal.. No ...
https://en.wikipedia.org/wiki/Algesic
Butalbital-D5 (0.1 mg/ml) in Methanol- CAS Number 145243-96-5Butalbital-D5 (0.1 mg/ml) in Methanol- CAS Number 145243-96-5
Benzydamine Hydrochloride. 10 mg. LGCFOR0142.00. In den Warenkorb Benzyl Benzoate. 10 mg. LGCFOR0570.00. In den Warenkorb ...
https://www.lgcstandards.com/DE/de/Butalbital-D5-0-1-mg-ml-in-Methanol/p/CERB-005
Levofloxacin: uses, dosage and side effectsLevofloxacin: uses, dosage and side effects
benzydamine. * celecoxib. * mefenamic acid. Vaccines. The oral typhoid vaccine (Vivotif) should not be taken until at least ...
https://www.netdoctor.co.uk/medicines/infection/a7618/tavanic-levofloxacin/
Rituximab and Hyaluronidase (Professional Patient Advice) - Drugs.comRituximab and Hyaluronidase (Professional Patient Advice) - Drugs.com
Exceptions: Benzocaine; Benzydamine; Cocaine (Topical); Dibucaine; Dyclonine; Ethyl Chloride; Hexylresorcinol; Lidocaine ( ...
https://www.drugs.com/ppa/rituximab-and-hyaluronidase.html
Bromocriptine mesilate Assay Standard- CAS Number 22260-51-1Bromocriptine mesilate Assay Standard- CAS Number 22260-51-1
Benzydamine hydrochloride Assay Standard. 100 mg. BP 610. Add to basket Benzyl benzoate Assay Standard. 0.1 mL. BP 426. Add to ...
https://www.lgcstandards.com/DE/en/Bromocriptine-mesilate-Assay-Standard/p/BP%20050
1-Propanamine, N,N-dimethyl-3-[[1-(phenylmethyl)-1H-indazol-3-yl]oxy]1-Propanamine, N,N-dimethyl-3-[[1-(phenylmethyl)-1H-indazol-3-yl]oxy]
Other names: 1H-Indazole, 1-benzyl-3-(3-(dimethylamino)propoxy)-; Benzindamine; Benzydamine; 1-Benzyl-3-(3-(dimethylamino) ...
https://webbook.nist.gov/cgi/cbook.cgi?ID=C642728&Units=CAL&Mask=FFFF
Hydrochloride0.15DifflamRinseLidocaineTantum VerdeMouthwashSorePropane gives benzydamineChlorhexidineEffects of benzydamineAnalgesicMucositisMedicationChlorideInteractionsBenzyl-indazoleVaginalInflammationMouth washVitroNumbnessSprayRecreationalCytokinesDosagePatientsBelongsOverdoseDosesPlaceboFindingsDrugsTreatmentsSeverity
Hydrochloride22
  • Benzydamine (also known as Tantum Verde and branded in some countries as Difflam and Septabene), available as the hydrochloride salt, is a locally acting nonsteroidal anti-inflammatory drug (NSAID) with local anaesthetic and analgesic properties for pain relief and anti-inflammatory treatment of inflammatory conditions of the mouth and throat. (wikipedia.org)
  • Difflam spray contains benzydamine hydrochloride, which works by stopping the production of various chemicals in the body that cause inflammation. (netdoctor.co.uk)
  • Lymphomatoid photocontact dermatitis to benzydamine hydrochloride. (sigmaaldrich.com)
  • To evaluate the analgesic effect of benzydamine hydrochloride dripping on the endotracheal tube cuff for postoperative sore throat. (clinicaltrials.gov)
  • The investigators will assign patients into either the benzydamine hydrochloride or the control group. (clinicaltrials.gov)
  • The whole ETT cuff will be either dripped with 3 ml (4.5 mg) of benzydamine hydrochloride or nothing 5 minutes prior to anesthesia induction. (clinicaltrials.gov)
  • The potential adverse effects of benzydamine hydrochloride (throat numbness, throat burning sensation, dry mouth and thirst) will also be evaluated. (clinicaltrials.gov)
  • The hypotheses are that benzydamine hydrochloride 0.15% oral rinse is better than vehicle oral rinse as measured by the proportion of patients reaching a WHO mucositis score of 3 by 5500 cGy and vehicle is no worse than the standard of care as measured by the proportion of patients reaching a WHO mucositis score of 3 by 5500 cGy. (clinicaltrials.gov)
  • Patients receiving benzydamine hydrochloride 0.15% or vehicle double-blind oral rinses will place 15 mL in the mouth for 2 minutes, gargling for a few seconds at the beginning and end of the rinse, and then expectorate the entire dose. (clinicaltrials.gov)
  • We compared the effects of benzydamine hydrochloride (BH), 10% lidocaine, and normal saline spray on preventing postoperative sore throat (POST) in patients who underwent total thyroidectomy (TT). (springer.com)
  • Benzydamine (benzydamine hydrochloride, PHARIXIA®) is a benzyl-indazole having analgesic, antipyretic, and anti-inflammatory effects. (ncats.io)
  • Benzydamine hydrochloride buccal bioadhesive gels designed for oral ulcers: preparation, rheological, textural, mucoadhesive and release properties. (ncats.io)
  • Effect on postoperative sore throat of spraying the endotracheal tube cuff with benzydamine hydrochloride, 10% lidocaine, and 2% lidocaine. (ncats.io)
  • The development and in vitro evaluation of sustained release tablet formulations of benzydamine hydrochloride and its determination. (ncats.io)
  • Benzydamine is produced as a hydrochloride salt. (psychonautwiki.org)
  • A simple technique of gargling performed preoperatively with benzydamine hydrochloride was effective in reducing POST with no evidence of any side effects. (msjonline.org)
  • Benzydamine hydrochloride for prophylaxis of radiation induced oral mucositis: results from a multicenter, randomized, double-blind, placebo-controlled clinical trial. (msjonline.org)
  • Kati I, Tekin M, Silay E, Huseyinoglu UA, Yildiz H. Does benzydamine hydrochloride applied preemptively reduce sore throat due to laryngeal mask airway? (msjonline.org)
  • The study tested magic mouthwash combined with another drug against benzydamine hydrochloride. (healthline.com)
  • Alfa Aesar MSDS] See "Benzydamine hydrochloride. (nih.gov)
  • Effect of benzydamine hydrochloride spray on postoperative pain relief after tonsillectomy. (springer.com)
  • Benzydamine Hydrochloride 3.00mg Cetylpyridinum Chloride 1.33mg. (netpharmacy.co.nz)
0.151
  • Group B patients received benzydamine 0.15% gargles while group C received placebo. (msjonline.org)
Difflam3
  • Difflam spray (benzydamine): how does it work? (netdoctor.co.uk)
  • Difflam spray contains benzydamine, which is a non-steroidal anti-inflammatory drug (NSAID), it acts as an analgesic and anti-inflammatory treatment for the throat and mouth. (netdoctor.co.uk)
  • Benzydamine (also known as Difflam or Tantum Verde ) is a topical anaesthetic of the indazole chemical class. (psychonautwiki.org)
Rinse8
  • Benzydamine liquid is used as a mouth rinse or gargle to soothe sore areas in the mouth or throat. (canada.com)
  • Benzydamine is a nonsteroidal anti-inflammatory drug that has been used in an oral rinse. (ons.org)
  • Benzydamine is a topical analgesic (oral rinse/gel) used to relieve painful mouth and throat conditions such as mouth ulcers, sore gums and sore throat. (internationaldrugmart.com)
  • Do not swallow Benzydamine oral rinse or gel. (internationaldrugmart.com)
  • There are no known interactions between Benzydamine oral rinse/gel and other medicines. (internationaldrugmart.com)
  • We evaluated the efficacy of benzydamine oral rinse for prevention of radiation-induced mucositis. (unboundmedicine.com)
  • Patients with head and neck cancers, who were referred in 2004-2005, received an oral rinse of either benzydamine or placebo. (unboundmedicine.com)
  • Benzydamine oral rinse seems to be effective, safe, and well tolerated for prophylactic treatment of radiation-induced oral mucositis in head and neck tumours. (unboundmedicine.com)
Lidocaine3
  • The medicines below all contain the following active ingredient(s): lidocaine (lignocaine) + benzydamine + dichlorobenzyl alcohol. (healthdirect.gov.au)
  • Lozenges that relieve these symptoms contain substances such as lidocaine, bezocaine, benzydamine and flubiprofen. (news-medical.net)
  • This contains benzydamine or lidocaine oral gel that numbs the pain over the ulcers. (news-medical.net)
Tantum Verde1
  • Benzydamine (awso known as Tantum Verde and branded in some countries as Diffwam and Septabene), avaiwabwe as de hydrochworide sawt, is a wocawwy acting nonsteroidaw anti-infwammatory drug (NSAID) wif wocaw anaesdetic and anawgesic properties for pain rewief and anti-infwammatory treatment of infwammatory conditions of de mouf and droat . (appspot.com)
Mouthwash4
  • Antimicrobial action of Nitens mouthwash (cetyltrimethylammonium naproxenate) on multiple isolates of pharyngeal microbes: a controlled study against chlorhexidine, benzydamine, hexetidine, amoxicillin, amoxicillin-clavulanate, clarithromycin, and cefaclor. (ncats.io)
  • Benzydamine mouthwash may be helpful. (bad.org.uk)
  • Aloe vera mouthwash was as beneficial as benzydamine mouthwash in alleviating the severity of radiation-induced mucositis. (greenmedinfo.com)
  • A topical analgesic (e.g. benzydamine mouthwash) may reduce pain. (pr.com)
Sore4
  • For sore throats , benzydamine should be gargled, 15 mL (1 tablespoonful) every 1½ to 3 hours. (canada.com)
  • Benzydamine is indicated as well for relief from pain and inflammatory conditions associated with sore throat or mouth sores caused by radiation therapy. (internationaldrugmart.com)
  • The benzydamine group B had no evidence of sore throat at 24 hours duration whereas group C had 36% of patients who still complained sore throat. (msjonline.org)
  • Is benzydamine gargle good for sore throat? (healthtap.com)
Propane gives benzydamine2
  • Treatment of the enolate of this amide with 3-chloro-1-dimethylamkino propane gives benzydamine (5). (wikipedia.org)
  • Treatment of de enowate of dis amide wif 3-chworo-1-dimedywamkino propane gives benzydamine ( 5 ). (appspot.com)
Chlorhexidine2
  • In a trial of chlorhexidine versus benzydamine, patients reported more discomfort with benzydamine and were more likely to discontinue participation in the trial. (ons.org)
  • The medicines below all contain the following active ingredient(s): benzydamine + chlorhexidine. (healthdirect.gov.au)
Effects of benzydamine2
  • Similarly to the in vivo paradigm, also the electrophysiological effects of benzydamine were potentiated in slices from animals that had undergone cocaine and heroin self-administration. (psychonautwiki.org)
  • demographic characteristics, drug use pattern (lifetime use, use in the past 30 days, frequency, and characteristics of use in the past month) and effects of benzydamine through the use of a questionnaire . (bvsalud.org)
Analgesic1
  • Benzydamine is a locally acting nonsteroidal anti-inflammatory drug with local anaesthetic and analgesic properties. (psychonautwiki.org)
Mucositis3
  • Benzydamine has been evaluated in patients with cancer for the prevention and management of mucositis. (ons.org)
  • Moderate evidence suggested that benzydamine is effective in relieving mouth pain caused by radiation-induced mucositis in patients with head and neck cancer. (ons.org)
  • or =2 mucositis was 24 days in the placebo group and 28 days in the benzydamine group (P = 0.12). (unboundmedicine.com)
Medication2
  • Do not use this medication if you are allergic to benzydamine or any ingredients of the medication. (canada.com)
  • If your physician has instructed or directed you to use Benzydamine medication in a regular schedule and you have missed a dose of this medicine, use it as soon as you remember. (internationaldrugmart.com)
Chloride1
  • Alkylation of the enol with sodium methoxide and 3-dimethylaminopropyl chloride gives benzydamine. (wikipedia.org)
Interactions1
  • However, it is important to inform your doctor about the use of any other medications including non-prescription medications (over-the-counter medicines that may increase the effect of Benzydamine) and dietary supplements like vitamins, minerals and herbal, so that the doctor can warn you of any possible drug interactions. (internationaldrugmart.com)
Benzyl-indazole1
  • Benzydamine, or 3-(1-benzylindazol-3-yl)oxy-N,N-dimethylpropan-1-amine, is a synthetic benzyl-indazole molecule. (psychonautwiki.org)
Vaginal1
  • Studies of treatments (vaginal oestrogens, benzydamine douches, dilators, and intercourse) were neither recent nor good quality. (cochrane.org)
Inflammation4
  • Benzydamine reduces inflammation and pain in the area its's applied to. (netdoctor.co.uk)
  • Benzydamine inhibits the synthesis of proinflammatory cytokines including tumour necrosis factor-α (TNF-α) and Interleukin-1β (IL-1β) w/o significantly affecting other proinflammatory (IL-6 and 8) or anti-inflammatory cytokines (IL-10, IL-1 receptor antagonist), thus reducing local pain and inflammation. (mims.com)
  • Benzydamine(Amigdazol Nf) generic Tantum Vag Douche is a locally-acting non-steroidal anti-inflammatory drug, prescribed for painful musculoskeletal and soft tissue disorders and inflammation of the mouth and throat. (medindia.net)
  • Benzydamine is also used to treat pain and inflammation following dental surgery. (internationaldrugmart.com)
Mouth wash1
  • The prescribed amount of Benzydamine should be used as a mouth wash around the mouth or as a gargle in the throat, for at least 30 seconds, and then it should be spit out. (internationaldrugmart.com)
Vitro2
  • Studies indicate that benzydamine has notable in vitro antibacterial activity and also shows synergism in combination with other antibiotics, especially tetracyclines, against antibiotic-resistant strains of Staphylococcus aureus and Pseudomonas aeruginosa. (wikipedia.org)
  • Studies indicate dat benzydamine has notabwe in vitro antibacteriaw activity and awso shows synergism in combination wif oder antibiotics, especiawwy tetracycwines, against antibiotic-resistant strains of Staphywococcus aureus and Pseudomonas aeruginosa . (appspot.com)
Numbness1
  • Benzydamine also acts as a mild local anaesthetic, causing numbness and pain relief at the site of application. (netdoctor.co.uk)
Spray1
  • Benzydamine spray is also available as the generic medicine. (netdoctor.co.uk)
Recreational5
  • Alternatively, benzydamine can be used as a powerful psychoactive hallucinogen for recreational purposes. (psychonautwiki.org)
  • The toxicity and long-term health effects of recreational benzydamine use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. (psychonautwiki.org)
  • To describe the recreational use of benzydamine , an anti-inflammatory drug, among street youth in Brazil . (bvsalud.org)
  • 78 reported lifetime recreational benzydamine use (67 cases identified only in three capitals). (bvsalud.org)
  • This study identifies the recreational use of benzydamine among street youth , mainly in the Northeast of Brazil , and also indicates the need for special controls on the dispensation of this substance. (bvsalud.org)
Cytokines1
  • When the cells were treated simultaneously with benzydamine and the cytokines IL-1beta or TNF-alpha, the agent benzydamine reduced (P (ncats.io)
Dosage2
Patients1
  • Nous avons comparé les effets de la vaporisation de chlorhydrate de benzydamine (CB), de lidocaïne 10 %, ou de solution saline sur la prévention des maux de gorge postopératoires chez les patients subissant une thyroïdectomie totale (TT). (springer.com)
Belongs1
  • Benzydamine belongs to a group of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). (internationaldrugmart.com)
Overdose2
Doses1
  • Anecdotal evidence from people within the psychonaut community who have tried benzydamine suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). (psychonautwiki.org)
Placebo1
  • Benzydamine and indomethacin were no different from placebo. (bmj.com)
Findings3
  • New pharmacologic and biochemical findings on the mechanism of action of the non-steroidal antiphlogistic, benzydamine. (wikipedia.org)
  • Findings related to benzydamine were inconsistent. (ons.org)
  • These findings provide firm evidence of the abuse liability of benzydamine and suggest a possible cannabinoidergic mechanism of action. (psychonautwiki.org)
Drugs2
  • What other drugs could interact with Benzydamine? (internationaldrugmart.com)
  • Benzydamine has a powerful reinforcing effect and that this effect is greatly facilitated in animals that already had substance experience, having previously self-administered heroin and cocaine , indicating cross sensitization between benzydamine and other common drugs of abuse. (psychonautwiki.org)
Treatments1
  • For treatment associated with radiation therapy , benzydamine should be started the day before the start of radiation therapy and continued daily during the treatment period, as well as after the treatments have stopped, until there is improvement in the discomfort. (canada.com)
Severity1
  • The aim of the study was to evaluate the effectiveness of benzydamine preoperative gargles in reducing the incidence and severity of POST. (msjonline.org)
Benzydamine N-oxide | C19H23N3O2 - PubChem
Benzydamine N-oxide | C19H23N3O2 - PubChem (pubchem.ncbi.nlm.nih.gov)
Difflam spray (benzydamine): how does it work?
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Home Remedies for Sore Throat
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Lymphomatoid photocontact dermatitis to benzydamine hydrochloride. | Sigma-Aldrich
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Analgesic - Wikipedia
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Drug - Tantum Vag Douche 500mg/1Sachet - 1 Sachet (Benzydamine) Price List or Cost of Medication | Medindia
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Levofloxacin: uses, dosage and side effects
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Budesonide Assay Standard- CAS Number 51333-22-3
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Benzydamine for Radiation-Related Mucositis | ONS
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Medijel pastilles
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Adcortyl in orabase (discontinued in the UK - March 2009)
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Virasorb cold sore cream (aciclovir)
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Dentinox teething gel
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Nystan oral suspension (nystatin)
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Lidocaine (lignocaine) + benzydamine + dichlorobenzyl alcohol | healthdirect
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Apo-Sulfasalazine - Uses, Side Effects, Interactions - MedBroadcast.com
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Quantitive systematic review of topically applied non-steroidal anti-inflammatory drugs | The BMJ
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Mouth ulcer - Wikipedia
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KEGG PATHWAY: hsa00590
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Meyler's Side Effects of Drugs - Elsevier Science & Technology - Literati by Credo
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Diazinon : Wikis (The Full Wiki)
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Buclizine - The Full Wiki
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Antiinflammatory and Antirheumatic Products - DrugBank
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N-Methyl-3-piperidyl benzilate - The Full Wiki
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Glossary | Bone Cancer Research Trust
Glossary | Bone Cancer Research Trust (bcrt.org.uk)
Head and Neck Cancer | GreenMedInfo | Disease | Natural Medicine
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Benzydamine Mouth Wash/Gel - Order online for Discount Price
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WHOCC - Alterations in ATCvet codes
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4 Ways to Heal a Bitten Tongue - wikiHow
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Difflam Plus Sore Throat Lozenges + Anaesthetic Berry 16 Lozenges - 9314057009239
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Mucous Membrane Pemphigoid | British Skin Foundation
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Marmoset Flavin-Containing Monooxygenase 3 in the Liver Is a Major Benzydamine and Sulindac Sulfide Oxygenase | Drug Metabolism...
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Treatment of hand, foot and mouth disease
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Prilosec Abdominal Pain Side Effects
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