Benzydamine
Oxygenases
Burning Mouth Syndrome
Anti-Inflammatory Agents, Non-Steroidal
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
Indonesia
A republic stretching from the Indian Ocean east to New Guinea, comprising six main islands: Java, Sumatra, Bali, Kalimantan (the Indonesian portion of the island of Borneo), Sulawesi (formerly known as the Celebes) and Irian Jaya (the western part of New Guinea). Its capital is Djakarta. The ethnic groups living there are largely Chinese, Arab, Eurasian, Indian, and Pakistani; 85% of the peoples are of the Islamic faith.
Administration, Topical
The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.
Therapeutic Irrigation
Vaginal Douching
Drug Information Services
Bisacodyl
Mouthwashes
Mucositis
An INFLAMMATION of the MUCOSA with burning or tingling sensation. It is characterized by atrophy of the squamous EPITHELIUM, vascular damage, inflammatory infiltration, and ulceration. It usually occurs at the mucous lining of the MOUTH, the GASTROINTESTINAL TRACT or the airway due to chemical irritations, CHEMOTHERAPY, or radiation therapy (RADIOTHERAPY).
Mouth
Chlorhexidine
Cape Verde
Rosa
Coriandrum
Medicine, African Traditional
Nursing Homes
Pharynx
A funnel-shaped fibromuscular tube that conducts food to the ESOPHAGUS, and air to the LARYNX and LUNGS. It is located posterior to the NASAL CAVITY; ORAL CAVITY; and LARYNX, and extends from the SKULL BASE to the inferior border of the CRICOID CARTILAGE anteriorly and to the inferior border of the C6 vertebra posteriorly. It is divided into the NASOPHARYNX; OROPHARYNX; and HYPOPHARYNX (laryngopharynx).
Tonsillitis
Tripelennamine
Carisoprodol
A centrally acting skeletal muscle relaxant whose mechanism of action is not completely understood but may be related to its sedative actions. It is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1202)
Orphenadrine
Hydroxyzine
Nefopam
Amitriptyline
Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
Povidone-Iodine
Honey
A sweet viscous liquid food, produced in the honey sacs of various bees from nectar collected from flowers. The nectar is ripened into honey by inversion of its sucrose sugar into fructose and glucose. It is somewhat acidic and has mild antiseptic properties, being sometimes used in the treatment of burns and lacerations.
Antifungal activity of local anesthetics against Candida species. (1/17)
OBJECTIVE: To evaluate the activity of benzydamine, lidocaine, and bupivacaine, three drugs with local anesthetic activity, against Candida albicans and non-albicans strains and to clarify their mechanism of activity. METHODS: The minimal inhibitory concentration (MIC) was determined for 20 Candida strains (18 clinical isolates and two American Type Culture Collection strains). The fungistatic activity was studied with the fluorescent probe FUN-1 and observation under epifluorescence microscopy and flow cytometry. The fungicidal activity of the three drugs was assayed by viability counts. Membrane alterations induced in the yeast cells were evaluated by staining with propidium iodide, by quantitation of intracellular K+ leakage and by transmission electron microscopy of intact yeast cells and prepared spheroplasts. RESULTS: The MIC ranged from 12.5-50.0 microg/mL, 5.0-40.0 mg/mL, and 2.5-10.0 mg/mL for benzydamine, lidocaine, and bupivacaine, respectively. The inhibitory activity of these concentrations could be detected with the fluorescent probe FUN-1 after incubation for 60 minutes. A very fast fungicidal activity was shown by 0.2, 50, and 30 mg/mL of benzydamine, lidocaine, and bupivacaine, respectively. CONCLUSIONS: At lower concentrations, the tested drugs have a fungistatic activity, due to yeast metabolic impairment, while at higher concentrations they are fungicidal, due to direct damage to the cytoplasmic membrane. (+info)In vitro evaluation of potential in vivo probes for human flavin-containing monooxygenase (FMO): metabolism of benzydamine and caffeine by FMO and P450 isoforms. (2/17)
AIMS To determine the FMO and P450 isoform selectivity for metabolism of benzydamine and caffeine, two potential in vivo probes for human FMO. METHODS Metabolic incubations were conducted at physiological pH using substrate concentrations of 0.01-10 mM with either recombinant human FMOs, P450s or human liver microsomes serving as the enzyme source. Products of caffeine and benzydamine metabolism were analysed by reversed-phase h.p.l.c. with u.v. and fluorescence detection. RESULTS CYP1A2, but none of the human FMOs, catalysed metabolism of caffeine. In contrast, benzydamine was a substrate for human FMO1, FMO3, FMO4 and FMO5. Apparent Km values for benzydamine N-oxygenation were 60 +/- 8 microM, 80 +/- 8 microM, > 3 mM and > 2 mM, for FMO1, FMO3, FMO4 and FMO5, respectively. The corresponding Vmax values were 46 +/- 2 min-1, 36 +/- 2 min-1, < 75 min-1 and < 1 min-1. Small quantities of benzydamine N-oxide were also formed by CYPs 1A1, 1A2, 2C19, 2D6 and 3A4. CONCLUSIONS: FMO1 and FMO3 catalyse benzydamine N-oxygenation with the highest efficiency. However, it is likely that the metabolic capacity of hepatic FMO3 is a much greater contributor to plasma levels of the N-oxide metabolite in vivo than is extrahepatic FMO1. Therefore, benzydamine, but not caffeine, is a potential in vivo probe for human FMO3. (+info)Benzydamine N-oxidation as an index reaction reflecting FMO activity in human liver microsomes and impact of FMO3 polymorphisms on enzyme activity. (3/17)
AIMS: The role of flavin containing monooxygenases (FMO) on the disposition of many drugs has been insufficiently explored. In vitro and in vivo tests are required to study FMO activity in humans. Benzydamine (BZD) N-oxidation was evaluated as an index reaction for FMO as was the impact of genetic polymorphisms of FMO3 on activity. METHODS: BZD was incubated with human liver microsomes (HLM) and recombinant enzymes. Human liver samples were genotyped using PCR-RFLP. RESULTS: BZD N-oxide formation rates in HLM followed Michaelis-Menten kinetics (mean Km = 64.0 microM, mean Vmax = 6.9 nmol mg-1 protein min-1; n = 35). N-benzylimidazole, a nonspecific CYP inhibitor, and various CYP isoform selective inhibitors did not affect BZD N-oxidation. In contrast, formation of BZD N-oxide was almost abolished by heat treatment of microsomes in the absence of NADPH and strongly inhibited by methimazole, a competitive FMO inhibitor. Recombinant FMO3 and FMO1 (which is not expressed in human liver), but not FMO5, showed BZD N-oxidase activity. Respective Km values for FMO3 and FMO1 were 40.4 microM and 23.6 microM, and respective Vmax values for FMO3 and FMO1 were 29.1 and 40.8 nmol mg-1 protein min-1. Human liver samples (n = 35) were analysed for six known FMO3 polymorphisms. The variants I66M, P135L and E305X were not detected. Samples homozygous for the K158 variant showed significantly reduced Vmax values (median 2.7 nmol mg-1 protein min-1) compared to the carriers of at least one wild type allele (median 6.2 nmol mg-1 protein min-1) (P < 0.05, Mann-Whitney-U-test). The V257M and E308G substitutions had no effect on enzyme activity. CONCLUSIONS: BZD N-oxidation in human liver is mainly catalysed by FMO3 and enzyme activity is affected by FMO3 genotype. BZD may be used as a model substrate for human liver FMO3 activity in vitro and may be further developed as an in vivo probe reflecting FMO3 activity. (+info)Flavin-containing monooxygenase activity in hepatocytes and microsomes: in vitro characterization and in vivo scaling of benzydamine clearance. (4/17)
Liver microsomes, and more recently cryopreserved hepatocytes, are commonly used in the in vitro characterization of the metabolism of new xenobiotics. The flavin-containing monooxygenases (FMO) are a major non p450 oxidase present in liver microsomes and hepatocytes. Since FMO is known to be thermally labile, and this enzyme may be involved in the metabolic clearance of some drugs, we sought to more completely characterize the metabolic competency of this enzyme in cryopreserved hepatocytes and in liver microsomes preincubated under various conditions using benzydamine as an in vitro and in vivo probe. The metabolism of benzydamine to its major metabolite, the N-oxide, is mediated by FMO3 in humans. We found that the in vitro microsomal t(1/2) was 70% longer when incubations were prewarmed at 37 degrees C in the absence of NADPH compared with prewarming in the presence of an NADPH-regenerating system, and N-oxide formation was inhibited >99%. Interestingly, the in vivo clearance predicted from these incubations and from human hepatocytes overpredicted the observed clearance of benzydamine in humans (>10.5 versus 2.4 ml/min/kg). In contrast, rat hepatocytes successfully predicted rat in vivo benzydamine clearance to within approximately 30% (>68 versus 48 ml/min/kg). Benzydamine N-oxidation in liver microsomes from all common preclinical species demonstrated heat sensitivity. This information should be considered when extrapolating metabolism data of xenobiotics from these in vitro systems. (+info)Benzydamine inhibits monocyte migration and MAPK activation induced by chemotactic agonists. (5/17)
1. The present study was aimed to investigate the effect of benzydamine, an anti-inflammatory drug devoid of activity on arachidonic acid metabolism, on monocyte chemotaxis and to define the possible biochemical correlates of activity. 2. Benzydamine inhibited monocyte chemotaxis in response to three classes of chemoattractants: the prototypic CC-chemokine CCL2 (MCP-1), the microbial product fMLP and the complement cascade component C5a. The effect was dose-dependent with IC50's of 100, 50 and 45 microm for MCP-1/CCL2, fMLP and C5a, respectively. At the dose of 100 microm, the effect resulted in a 50+/-10% inhibition of MCP-1/CCL2-induced chemotaxis and 53+/-6 and 54+/-5% inhibitions of chemotaxis in response of fMLP and C5a, respectively (n=3). 3. Receptor expression as well as calcium fluxes in response to chemoattractants were not affected by benzydamine. 4. Benzydamine strongly inhibited chemoattractant-induced activation of the mitogen-activated protein kinase (MAPK) ERK1/2, and of its upstream activator kinase MEK1/2. ERK1/12 activation in response to chemoattractants was 89-98% inhibited by a 100 microm concentration of benzydamine with an IC50 of 30 microm. 5. Under the same experimental conditions, pretreatment with 100 microm benzydamine caused a 75-89% inhibition of p38 activation (IC50 25 microm). 6. These results indicate that the anti-inflammatory activity of benzydamine is exerted at multiple levels, including monocyte migration to chemotactic factors associated to a blockage of ERK and p38 MAPK pathways. (+info)Effect of genetic variants of the human flavin-containing monooxygenase 3 on N- and S-oxygenation activities. (6/17)
The decreased capacity of the flavin-containing monooxygenase 3 (FMO3) to oxygenate xenobiotics including trimethylamine is believed to contribute to metabolic disorders. The aim of this study was to functionally characterize FMO3 variants recently found in a Japanese population and compare them with selective functional activity of other FMO3 variants. Recombinant Glu158Lys and Glu158Lys-Glu308Gly FMO3 expressed in Escherichia coli membranes showed slightly decreased N-oxygenation of benzydamine and trimethylamine. Selective functional S-oxygenation of these variants by methyl p-tolyl sulfide or sulindac sulfide was comparable to that of wild-type FMO3. The Glu158Lys-Thr201Lys-Glu308Gly and Val257Met-Met260Val variants showed significantly decreased oxygenation of typical FMO3 substrates (i.e., approximately one-tenth of the V(max)/K(m) values). Val257Met FMO3 had a lower catalytic efficiency for methyl p-tolyl sulfide and sulindac sulfide S-oxygenation. However, compared with wild-type FMO3, Val257Met FMO3 showed a similar catalytic efficiency for N-oxygenation of benzydamine and trimethylamine. The catalytic efficiency for benzydamine and trimethylamine N-oxygenation by Arg205Cys FMO3 was only moderately decreased, but it possessed decreased sulindac sulfide S-oxygenation activity. Kinetic analysis showed that Arg205Cys FMO3 was inhibited by sulindac in a substrate-dependent manner, presumably because of selective interaction between the variant enzyme and the substrate. The results suggest that the effects of genetic variation of human FMO3 could operate at the functional level for N- and S-oxygenation for typical FMO3 substrates. Genetic polymorphism in the human FMO3 gene might lead to unexpected changes of catalytic efficiency for N- and S-oxygenation of xenobiotics and endogenous materials. (+info)Inter-individual variation in flavin-containing monooxygenase 3 in livers from Japanese: correlation with hepatic transcription factors. (7/17)
Human flavin-containing monooxygenase 3 (FMO3)-mediated microsomal oxygenation activity, levels of FMO3 protein and FMO3 mRNA and modifications were investigated in Japanese livers genotyped for the FMO3 gene. Significant correlations were observed for benzydamine N-oxygenation or methyl p-tolyl sulfide S-oxygenation activity (in the range of approximately 20- to approximately 40-fold) and FMO3 levels determined immunochemically in liver microsomes (r(2)=0.73-0.75, p<0.0001, n=16). Preincubation with the reducing agent ascorbate revealed that FMO3 activity in some liver samples is suppressed. Microsomal FMO3 protein content (approximately 40-fold) was correlated with FMO3 mRNA levels (r(2)=0.55, p=0.0010, n=16), but FMO3 haplotypes did not affect FMO3 mRNA expression (approximately 100-fold) under the conditions used. FMO3 mRNA levels were multivariately correlated with trans-acting factors, i.e. hepatic nuclear factor 4 (HNF-4) mRNA and nuclear factor Y box-binding protein (NF-Y) mRNA (r(2)=0.31, p=0.0017, n=37). These results suggest that considerable individual differences in FMO3 levels may exist in Japanese livers. The liver-enriched transcription factor HNF-4 appears to be a determinant of FMO3 expression in livers, as well as the ubiquitous factor NF-Y. (+info)Recreational use of benzydamine as a hallucinogen among street youth in Brazil. (8/17)
(+info)
Benzydamine HCl for Postoperative Sore Throat - Full Text View - ClinicalTrials.gov
Safety & Efficacy Study of Benzydamine Oral Rinse for the Treatment of Oral Mucositis (Mouth Sores) Resulting From Radiation...
Blog - Difflam
Benzydamine mouthwash, curcumin and honey prevent/ reduce oral mucositis severity
Benzydamine - PsychonautWiki
Benzydamine: Indication, Dosage, Side Effect, Precaution | MIMS Indonesia
Causes of mouth ulcers - Irelands Health Service
Drug - Tantum Vag Douche 500mg/1Sachet - 1 Sachet (Benzydamine) Price List or Cost of Medication | Medindia
Difflam Sore Throat Rinse 200ml - Chemist Extra
Partial purification and substrate specificity of flavin-containing monooxygenase from rat brain microsomes
Novel variants of the human flavin-containing monooxygenase 3 (FMO3) gene associated with trimethylaminuria
Sci. Pharm. | Free Full-Text | Interaction between DNA and Drugs Having Protonable Basic Groups: Characterization through...
Radiotherapy and Oral Health
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Effect of Substitution on the Aniline Moiety of the GPR88 Agonist 2-PCCA | RTI
British Library EThOS: Studies of some organo-nitrogen three-electron ligands in transition metal carbonyl complexes
5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(p-tolyl)pyrimidine | CAS No. 1402172-42-2 | Sigma-Aldrich
2-(p-Tolyl)butanoyl chloride | C11H13ClO - PubChem
P-tolyl sulfoxide Global Market and Forecast Research : ReportsnReports
1-(p-Tolyl)piperazine dihydrochloride | C11H18Cl2N2 - PubChem
P-TOLYL ACETATE | FEMA
Flavin-containing monooxygenase 3 - Wikipedia
1,3,3-trimethyl-2-[[methyl(p-tolyl)hydrazono]me... - Registration Dossier - ECHA
Flavin-containing monooxygenase - Wikipedia
4-(Methylsulfonyl)toluene 97 % | 3185-99-7 | Sigma-Aldrich
Effects of feeding on the disposition of lorazepam and diazepam
Identification of Flavin-Containing Monooxygenase 5 (FMO5) as a Regulator of Glucose Homeostasis and a Potential Sensor of Gut...
Dentahex Oral Rinse l Antimicrobial Oral Rinse For Pets | Medi-Vet
Spry Cool Mint Natural Oral Rinse
Recombinant Human FMO5 protein (ab57977) References
p-Tolyl isothiocyanate
Citation tools | Drug Metabolism & Disposition
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CRYSTAL AND MOLECULAR-STRUCTURE OF B,B-BIS(P-TOLYL)BOROXAZOLIDINE AND ORTHORHOMBIC FORM OF B,B-DIPHENYLBOROXAZOLIDINE | UBC...
High Rate of Head-and-Neck Cancer in Women Pinned to Smoking | Medpage Today
Chemoradiation Lessens Need for Surgery in Head-and-Neck Cancer | Medpage Today
Oral Rinse & Mouthwash | Randalls
TheraBreath Oral Rinse 1-Liter | TheraBreath
RCSB PDB - Protein Feature View
- Putative flavin-containing monooxygenase - Q83XK4 (Q83XK4 9GAMM)
Fmo1 - Dimethylaniline monooxygenase [N-oxide-forming] 1 - Mus musculus (Mouse) - Fmo1 gene & protein
Antioxidant oral care kit - TeraGanix
Diphenhydramine
Benzydamine Dramamine Promethazine Hubbard, John R.; Martin, Peter R. (2001). Substance Abuse in the Mentally and Physically ...
Analgesic
Benzydamine. Comes in free acid form; freely soluble in water.. As per diclofenac.. Topical, PO, rectal, spray and vaginal.. No ...
Bendazac
Use of chloroacetamide in the alkylation step, followed by acid hydrolysis produces bendazac (instead of benzydamine). ... Benzydamine v t e v t e. ...
Mouth ulcer
A topical analgesic (e.g. benzydamine mouthwash) may reduce pain. Topical (gels, creams or inhalers) or systemic steroids may ...
Curtius rearrangement
... benzydamine, gabapentin, igmesine and tecadenoson. R. B. Woodward et al. used the Curtius rearrangement as one of the steps in ...
Nonsteroidal anti-inflammatory drug
... and benzydamine.[medical citation needed] Benoxaprofen, since withdrawn due to its liver toxicity, was the most photoactive ...
ATC code M01
QM01AH95 Enflicoxib M01AX01 Nabumetone M01AX02 Niflumic acid M01AX04 Azapropazone M01AX05 Glucosamine M01AX07 Benzydamine ...
Convention on Psychotropic Substances
... benzydamine (deliriant and stimulant, used medically as a non-steroidal anti-inflammatory drug) propofol and fospropofol ( ...
List of MeSH codes (D03)
... benzydamine MeSH D03.438.449.350 - granisetron MeSH D03.438.473.025 - adrenochrome MeSH D03.438.473.050 - alcian blue MeSH ... benzydamine MeSH D03.383.129.539.487.350 - granisetron MeSH D03.383.129.539.550 - muzolimine MeSH D03.383.129.539.650 - ...
ATC code A01
... combinations A01AD01 Epinephrine A01AD02 Benzydamine A01AD05 Acetylsalicylic acid A01AD06 Adrenalone A01AD07 Amlexanox A01AD08 ...
AB-FUBINACA
ADB 5F-AMB 5F-APINACA AB-CHFUPYCA AB-CHMINACA AB-PINACA ADB-CHMINACA ADB-FUBINACA ADBICA AMB-FUBINACA APICA APINACA Benzydamine ...
ATC code R02
Benzocaine R02AD02 Lidocaine R02AD03 Cocaine R02AD04 Dyclonine R02AX01 Flurbiprofen R02AX02 Ibuprofen R02AX03 Benzydamine "ATC ...
Index of oncology articles
... benzydamine - Beriplast P - best practice - beta alethine - beta carotene - beta hemolytic streptococcus group B - beta- ...
Mouthwash
In painful oral conditions such as aphthous stomatitis, analgesic mouthrinses (e.g. benzydamine mouthwash, or "Difflam") are ...
ATC code M02
M02AA01 Phenylbutazone M02AA02 Mofebutazone M02AA03 Clofezone M02AA04 Oxyphenbutazone M02AA05 Benzydamine M02AA06 Etofenamate ...
List of drugs: Be
Benzydamine (INN) Benzyl Benzoate Benzylpenicillin (INN) Benzylsulfamide (INN) Bepadin Bepafant (INN) Beperidium iodide (INN) ...
ATC code G02
Cabergoline G02CB04 Quinagolide G02CB05 Metergoline G02CB06 Terguride G02CC01 Ibuprofen G02CC02 Naproxen G02CC03 Benzydamine ...
C19H23N3O
The molecular formula C19H23N3O (molar mass: 309.40 g/mol, exact mass: 309.1841 u) may refer to: A-412,997 Benzydamine This set ...
Benzydamine
"Benzydamine oral rinse". Medicinenet. "Difflam spray (benzydamine)". Net Doctor, UK. "Tantum Verde (benzydamine)". Carysfort ... There are no contraindications to the use of benzydamine except for known hypersensitivity. Benzydamine is well tolerated. ... Fanaki NH, El-Nakeeb MA (March 1996). "Antibacterial activity of benzydamine and antibiotic-benzydamine combinations against ... Benzydamine is poorly absorbed through skin and vagina. Synthesis starts with the reaction of the N-benzyl derivative from ...
Fesoterodine
InChI=1S/C26H37NO3/c1-18(2)26(29)30-25-13-12-21(17-28)16-24(25)23(22-10-8-7-9-11-22)14-15-27(19(3)4)20(5)6/h7-13,16,18-20,23,28H,14-15,17H2,1-6H3/t23-/m1/s1 ...
Yohimbine
In the US, "yohimbe" preparations are sold as a dietary supplements for enhancing libido, for weight loss and as aids for bodybuilding; but "There is virtually no published research on yohimbe which supports these or any other claims".[9]:861 Often, these products explicitly claim to contain yohimbine.[8] Cohen et al. found that samples of brands sold in American brick-and-mortar stores contained highly variable amounts of yohimbine, and sometimes none at all.[8]:368 Labelling claims were often misleading.[8]:368 Similar results have been reported by other laboratories for products sold in the U.S., in other countries and on the internet.[15][16][17][18][19] One study found that many brands of "yohimbe" might not derive from the P. johimbe tree in the first place.[20] According to yet another source the yohimbe sold in markets in West Africa, where the tree grows, is frequently adulterated with other species of the genus Pausinystalia; these contain little yohimbine.[21] The amounts of alkaloid ...
Superoxide dismutase
Superoxide is one of the main reactive oxygen species in the cell. As a consequence, SOD serves a key antioxidant role. The physiological importance of SODs is illustrated by the severe pathologies evident in mice genetically engineered to lack these enzymes. Mice lacking SOD2 die several days after birth, amid massive oxidative stress.[26] Mice lacking SOD1 develop a wide range of pathologies, including hepatocellular carcinoma,[27] an acceleration of age-related muscle mass loss,[28] an earlier incidence of cataracts, and a reduced lifespan. Mice lacking SOD3 do not show any obvious defects and exhibit a normal lifespan, though they are more sensitive to hyperoxic injury.[29] Knockout mice of any SOD enzyme are more sensitive to the lethal effects of superoxide-generating compounds, such as paraquat and diquat (herbicides). Drosophila lacking SOD1 have a dramatically shortened lifespan, whereas flies lacking SOD2 die before birth. SOD knockdowns in the worm C. elegans do not cause major ...
A-366,833
Ji, Jianguo; Bunnelle, William H.; Anderson, David J.; Faltynek, Connie; Dyhring, Tino; Ahring, Philip K.; Rueter, Lynne E.; Curzon, Peter; Buckley, Michael J.; Marsh, Kennan C.; Kempf-Grote, Anita; Meyer, Michael D. (2007). "A-366833: A novel nicotinonitrile-substituted 3,6-diazabicyclo[3.2.0]-heptane α4β2 nicotinic acetylcholine receptor selective agonist: Synthesis, analgesic efficacy and tolerability profile in animal models". Biochemical Pharmacology. 74 (8): 1253-1262. doi:10.1016/j.bcp.2007.08.010. PMID 17854775 ...
Methantheline
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Captodiame
... (INN), also known as captodiamine, is an antihistamine sold under the trade names Covatine, Covatix, and Suvren which is used as a sedative and anxiolytic. The structure is related to diphenhydramine.[1] A 2004 study suggested captodiame may be helpful in preventing benzodiazepine withdrawal syndrome in people discontinuing benzodiazepine treatment.[1] In addition to its actions as an antihistamine, captodiamine has been found to act as a 5-HT2C receptor antagonist and σ1 receptor and D3 receptor agonist.[2] It produces antidepressant-like effects in rats.[2] However, captodiamine is unique among antidepressant-like drugs in that it increases brain-derived neurotrophic factor (BDNF) levels in the hypothalamus but not in the frontal cortex or hippocampus.[2] This unique action may be related to its ability to attenuate stress-induced anhedonia and corticotropin-releasing factor (CRF) signaling in the hypothalamus.[2] ...
4-Benzylpiperidine
... is a drug and research chemical used in scientific studies. It acts as a monoamine releasing agent with 20- to 48-fold selectivity for releasing dopamine versus serotonin. It is most efficacious as a releaser of norepinephrine, with an ec50 of 109/41.4/5246nM for DA/NE/5HT, respectively .[1] It has a fast onset of action and a short duration.[1] It also functions as a monoamine oxidase inhibitor (MAOI) with preference for MAO-A.[2] ...
RTI-229
... , also known as (-)-3β-(4-iodophenyl)tropane-2β-pyrrolidine carboxamide and RTI-4229-229, is a potent and long-lasting stimulant drug which was developed in the 1990s as part of a large group of related analogues from the phenyltropane family. With the combination of two potent dopamine transporter (DAT) binding motifs attached to the tropane ring, the p-iodophenyl group at the 3β-position and a pyrrolidine carboxamide at 2β, RTI-229 has extremely high selectivity for the dopamine transporter (2600x and 4600x selective over NET and 5-HTT respectively) and is one of the most DAT-selective compounds in the RTI series.[1][2] ...
Ergoline
There are a variety of clinically useful ergoline derivatives for the purpose of vasoconstriction, the treatment of migraines, and treatment of Parkinson's disease. Ergoline alkaloids found their place in pharmacology long before modern medicine as preparations of ergot were often used by midwives in the 12th century to stimulate childbirth.[10] Following Arthur Stoll's isolation of ergometrine, the therapeutic use of ergoline derivatives became well explored. The induction of uterine contractions via the preparation of ergot was attributed to ergonovine, an ergoline derivative found in ergot, which is a powerful oxytocic. From this, methergine, a synthetic derivative, was elucidated.[7] While used to facilitate child birth, ergoline derivatives can pass into breast milk and should not be used during breastfeeding.[11] They are uterine contractors that can increase the risk of miscarriage during pregnancy.[3] Another example of medically relevant ergoline alkaloids is ergotamine, an alkaloid ...
Ketorolac
In the US, ketorolac is the only widely available intravenous NSAID. An IV form of paracetamol, which is not an NSAID, became available in Europe in 2009 and then in the US.[13] The Syntex company, of Palo Alto, California developed the ophthalmic solution Acular[25] around 2006, which is currently licensed by Allergan, Inc.[26][27] In 2007, there were concerns about the high incidence of reported side effects. This led to restriction in its dosage and maximum duration of use. In the UK, treatment was initiated only in a hospital, although this was not designed to exclude its use in prehospital care and mountain rescue settings.[1] Dosing guidelines were published at that time.[28] Concerns over the high incidence of reported side effects with ketorolac trometamol led to its withdrawal (apart from the ophthalmic formulation) in several countries, while in others its permitted dosage and maximum duration of treatment have been reduced. From 1990 to 1993, 97 reactions with a fatal outcome were ...
Clidinium bromide
Used in fixed combination with chlordiazepoxide as adjunctive therapy in the treatment of peptic ulcer disease; however, no conclusive data that antimuscarinics aid in the healing, decrease the rate of recurrence, or prevent complications of peptic ulcers.[2] With the advent of more effective therapies for the treatment of peptic ulcer disease, antimuscarinics have only limited usefulness in this condition. ...
Benzydamine - Wikipedia
"Benzydamine oral rinse". Medicinenet. "Difflam spray (benzydamine)". Net Doctor, UK. "Tantum Verde (benzydamine)". Carysfort ... There are no contraindications to the use of benzydamine except for known hypersensitivity. Benzydamine is well tolerated. ... Fanaki NH, El-Nakeeb MA (March 1996). "Antibacterial activity of benzydamine and antibiotic-benzydamine combinations against ... Benzydamine is poorly absorbed through skin and vagina. Synthesis starts with the reaction of the N-benzyl derivative from ...
Difflam spray (benzydamine): how does it work?
Benzydamine reduces inflammation and pain in the area itss applied to.. Benzydamine also acts as a mild local anaesthetic, ... Difflam spray contains benzydamine, which is a non-steroidal anti-inflammatory drug (NSAID), it acts as an analgesic and anti- ... Difflam spray contains benzydamine hydrochloride, which works by stopping the production of various chemicals in the body that ...
Lymphomatoid photocontact dermatitis to benzydamine hydrochloride. | Sigma-Aldrich
Benzydamine HCl for Postoperative Sore Throat - Full Text View - ClinicalTrials.gov
Drug: benzydamine HCl 3 ml (4.5 mg) of benzydamine hydrochloride will be dripped on the cuff of the endotracheal tube 5 minutes ... Experimental: benzydamine HCl benzydamine HCl will be dripped on the cuff of the endotracheal tube 5 minutes before induction ... Benzydamine HCl for Postoperative Sore Throat (POST). The safety and scientific validity of this study is the responsibility of ... side effects of benzydamine hydrochloride [ Time Frame: 24 hours ]. the incidence of throat numbness, throat burning sensation ...
Actifedrin Lozenges (Benzydamine Hydrochloride) Investi Farma
Difflam-C (Benzydamine Hydrochloride; Chlorhexidine Gluconate) 3M
Benzydamine N-oxide | C19H23N3O2 - PubChem
Dom-Benzydamine - Uses, Side Effects, Interactions - Canada.com
Benzydamine liquid is used to relieve the pain and inflammation associated with a sore throat or with mouth sores caused by ... Benzydamine liquid is used to relieve the pain and inflammation associated with a sore throat or with mouth sores caused by ... Do not use this medication if you are allergic to benzydamine or any ingredients of the medication. ... Benzydamine liquid is used as a mouth rinse or gargle to soothe sore areas in the mouth or throat. It should not be swallowed. ...
Benzydamine for Radiation-Related Mucositis | ONS
Benzydamine has been evaluated in patients with cancer for the prevention and management of mucositis. ... Benzydamine is a nonsteroidal anti-inflammatory drug that has been used in an oral rinse. It has some local anesthetic and ... Benzydamine for Radiation-Related Mucositis. for Mucositis. Benzydamine is a nonsteroidal anti-inflammatory drug that has been ... Findings related to benzydamine were inconsistent. In a trial of chlorhexidine versus benzydamine, patients reported more ...
lidocaine (lignocaine) + benzydamine + dichlorobenzyl alcohol | healthdirect
... benzydamine + dichlorobenzyl alcohol including side effects, age restrictions, food interactions, whether the medicine is ... Medicines that contain lidocaine (lignocaine) + benzydamine + dichlorobenzyl alcohol *Difflam Anaesthetic, Antibacterial and ... Active ingredient: lidocaine (lignocaine) + benzydamine + dichlorobenzyl alcohol. The medicines below all contain the following ... active ingredient(s): lidocaine (lignocaine) + benzydamine + dichlorobenzyl alcohol. You can select a medicine from this list ...
Benzydamine: Indication, Dosage, Side Effect, Precaution | MIMS Indonesia
Benzydamine: Belongs to the class of other throat preparations., Belongs to the class of non-steroidal antiinflammatory ... R02AX03 - benzydamine ; Belongs to the class of other throat preparations. M02AA05 - benzydamine ; Belongs to the class of non- ... Description: Benzydamine inhibits the synthesis of proinflammatory cytokines including tumour necrosis factor-α (TNF-α) and ... M01AX07 - benzydamine ; Belongs to the class of other non-steroidal antiinflammatory and antirheumatic products. ...
Drug - Tantum Vag Douche 500mg/1Sachet - 1 Sachet (Benzydamine) Price List or Cost of Medication | Medindia
Benzydamine) drug information. Find its price or cost, dose, when to use, how to use, side effects, adverse effects, ... Drug Name : Benzydamine. Benzydamine(Amigdazol Nf) generic Tantum Vag Douche is a locally-acting non-steroidal anti- ... Pms-Benzydamine, Ratio-Benzydamine, Rosalgin Pronto, Rosalgin, Sandival, Saniflor, Septolux, Tanflex, Tantum Bucal, Tantum ... Other Trade Names for Benzydamine. India : Zigat-D (3%/0.1%) , Dexasone DPS (0.1%/0.5%) , Daksone (8mg) , Dexona (0.5mg) , ...
Benzydamine Mouth Wash/Gel - Order online for Discount Price
We at our online pharmacy have Benzydamine oral rinse 0.15% and 15% gel. Order and & save upto $29.28. It reduces the pain and ... How will Benzydamine work in my body?. How should Benzydamine be used?. How to reduce the risk of Benzydamine drug interactions ... What are the questions to ask your doctor before taking Benzydamine? Is it possible for me to use Benzydamine with other drugs? ... Do not swallow Benzydamine oral rinse or gel. The prescribed amount of Benzydamine should be used as a mouth wash around the ...
Safety & Efficacy Study of Benzydamine Oral Rinse for the Treatment of Oral Mucositis (Mouth Sores) Resulting From Radiation...
Patients receiving benzydamine hydrochloride 0.15% or vehicle double-blind oral rinses will place 15 mL in the mouth for 2 ... Known hypersensitivity to benzydamine HCl and/or any of the other components including alcohol, menthol, glycerin, flavoring ... The purpose of this study is to compare the effectiveness and safety of benzydamine hydrochloride 0.15% oral rinse to a vehicle ... The hypotheses are that benzydamine hydrochloride 0.15% oral rinse is better than vehicle oral rinse as measured by the ...
The effect of benzydamine hydrochloride on preventing postoperative sore throat after total thyroidectomy: a randomized...
We compared the effects of benzydamine hydrochloride (BH), 10% lidocaine, and normal saline spray on preventing postoperative ... Table 2 Incidence of postoperative sore throat in control (C), lidocaine (L) and benzydamine hydrochloride (B) groups. Full ... Benzydamine hydrochloride (BH) is a well-known topical non-steroidal anti-inflammatory drug (NSAID)8 that effectively reduces ... Kim, D., Jeong, H., Kwon, J. et al. The effect of benzydamine hydrochloride on preventing postoperative sore throat after total ...
Benzydamine - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | RxWiki
PRIME PubMed | Benzydamine for prophylaxis of radiation-induced oral mucositis in head and neck cancers: a double-blind placebo...
Benzydamine for prophylaxis of radiation-induced oral mucositis in head and neck cancers: a double-blind placebo-controlled ... AdolescentAdultAgedAged, 80 and overAnti-Inflammatory AgentsBenzydamineChildDouble-Blind MethodFemaleHead and Neck Neoplasms ... 2 mucositis was 24 days in the placebo group and 28 days in the benzydamine group (P = 0.12). Benzydamine oral rinse seems to ... 2 mucositis was 24 days in the placebo group and 28 days in the benzydamine group (P = 0.12). Benzydamine oral rinse seems to ...
Marmoset Flavin-Containing Monooxygenase 3 in the Liver Is a Major Benzydamine and Sulindac Sulfide Oxygenase | Drug Metabolism...
BENZYDAMINE
... (benzydamine hydrochloride, PHARIXIA®) is a benzyl-indazole having analgesic, antipyretic, and anti-inflammatory ... When the cells were treated simultaneously with benzydamine and the cytokines IL-1beta or TNF-alpha, the agent benzydamine ... Benzydamine Created by admin. on Tue Mar 06 11:57:00 UTC 2018. , Edited by admin. on Tue Mar 06 11:57:00 UTC 2018. ... Furthermore, benzydamine reduced (P < 0.05) both the basal level and the cytokine-induced 3H-arachidonic acid release in ...
Benzydamine - PsychonautWiki
Benzydamine (also known as Difflam or Tantum Verde) is a topical anaesthetic of the indazole chemical class. It is sometimes ... Benzydamine (Reddit). References. *↑ 1.0 1.1 Recreational abuse with benzydamine hydrochloride (tantum rosa) (PubMed.gov / NCBI ... Benzydamine, or 3-(1-benzylindazol-3-yl)oxy-N,N-dimethylpropan-1-amine, is a synthetic benzyl-indazole molecule. Benzydamine ... Benzydamine (also known as Difflam or Tantum Verde) is a topical anaesthetic of the indazole chemical class. It is sometimes ...
Benzydamine - Wikipedia
"Diffwam spray (benzydamine)". Net Doctor, UK.. *. "Tantum Verde (benzydamine)". Carysfort Heawdcare Limited, Irewand. Archived ... Fanaki NH, Ew-Nakeeb MA (March 1996). "Antibacteriaw activity of benzydamine and antibiotic-benzydamine combinations against ... Benzydamine has been used recreationawwy. In overdosages it acts as a dewiriant and CNS stimuwant.[4] Such use, particuwarwy ... Studies indicate dat benzydamine has notabwe in vitro antibacteriaw activity and awso shows synergism in combination wif oder ...
benzydamine + chlorhexidine | healthdirect
Farhex - Drugs.com
Home Remedies for Sore Throat
Benzydamine Hydrochloride Impurity A - 2196185-65-4 Fountainbridge
Recreational use of benzydamine as a hallucinogen among street youth in Brazil | Rev. bras. psiquiatr;31(3): 208-213, Sept....
... and effects of benzydamine through the use of a questionnaire. RESULTS:. 78 reported lifetime recreational benzydamine use (67 ... Full text: Available Index: LILACS (Americas) Main subject: Benzydamine / Illicit Drugs / Homeless Youth / Substance-Related ... Full text: Available Index: LILACS (Americas) Main subject: Benzydamine / Illicit Drugs / Homeless Youth / Substance-Related ... To describe the recreational use of benzydamine, an anti-inflammatory drug, among street youth in Brazil. METHOD:. Design:. a ...
Vaginal Delivery of Benzydamine Hydrochloride through Liposomes Dispersed in Mucoadhesive Gels | AVESİS
Dental Care Products - Benzydamine Hcl 0.15% Mouth Wash Wholesale Trader from Chandigarh
Analgesic - Wikipedia
Benzydamine mouthwash, curcumin and honey prevent/ reduce oral mucositis severity
... by ICPA HEALTH PRODUCTS LTD ... Benzydamine mouthwash has been in use for many years. Now, the literature gives the much needed evidence-based confidence to ... Benzydamine mouthwash along with traditional curcumin & honey can prevent or reduce the severity of oral mucositis. This ... Benzydamine mouthwash, curcumin and honey prevent/ reduce oral mucositis severity * Chlorhexidine gluconate - the most ...
HydrochlorideMouthwash0.15MucositisDifflamChlorhexidineRinseLidocaineTantum VerdeAnalgesicSorePropane gives benzydamineEffects of benzydamineMedicationInteractionsBenzyl-indazoleVitroInflammationChlorideMouth washMouthwashesVaginalNumbnessSprayRecreationalCytokinesSeverityDosagePatientsBelongsSodiumOverdoseToxicityDosesPlaceboFindingsDrugsTreatments
Hydrochloride25
- Benzydamine (also known as Tantum Verde and branded in some countries as Difflam and Septabene), available as the hydrochloride salt, is a locally acting nonsteroidal anti-inflammatory drug (NSAID) with local anaesthetic and analgesic properties for pain relief and anti-inflammatory treatment of inflammatory conditions of the mouth and throat. (wikipedia.org)
- Difflam spray contains benzydamine hydrochloride, which works by stopping the production of various chemicals in the body that cause inflammation. (netdoctor.co.uk)
- Lymphomatoid photocontact dermatitis to benzydamine hydrochloride. (sigmaaldrich.com)
- To evaluate the analgesic effect of benzydamine hydrochloride dripping on the endotracheal tube cuff for postoperative sore throat. (clinicaltrials.gov)
- The investigators will assign patients into either the benzydamine hydrochloride or the control group. (clinicaltrials.gov)
- The whole ETT cuff will be either dripped with 3 ml (4.5 mg) of benzydamine hydrochloride or nothing 5 minutes prior to anesthesia induction. (clinicaltrials.gov)
- The potential adverse effects of benzydamine hydrochloride (throat numbness, throat burning sensation, dry mouth and thirst) will also be evaluated. (clinicaltrials.gov)
- The hypotheses are that benzydamine hydrochloride 0.15% oral rinse is better than vehicle oral rinse as measured by the proportion of patients reaching a WHO mucositis score of 3 by 5500 cGy and vehicle is no worse than the standard of care as measured by the proportion of patients reaching a WHO mucositis score of 3 by 5500 cGy. (clinicaltrials.gov)
- Patients receiving benzydamine hydrochloride 0.15% or vehicle double-blind oral rinses will place 15 mL in the mouth for 2 minutes, gargling for a few seconds at the beginning and end of the rinse, and then expectorate the entire dose. (clinicaltrials.gov)
- We compared the effects of benzydamine hydrochloride (BH), 10% lidocaine, and normal saline spray on preventing postoperative sore throat (POST) in patients who underwent total thyroidectomy (TT). (springer.com)
- Benzydamine (benzydamine hydrochloride, PHARIXIA®) is a benzyl-indazole having analgesic, antipyretic, and anti-inflammatory effects. (ncats.io)
- Benzydamine hydrochloride buccal bioadhesive gels designed for oral ulcers: preparation, rheological, textural, mucoadhesive and release properties. (ncats.io)
- Effect on postoperative sore throat of spraying the endotracheal tube cuff with benzydamine hydrochloride, 10% lidocaine, and 2% lidocaine. (ncats.io)
- The development and in vitro evaluation of sustained release tablet formulations of benzydamine hydrochloride and its determination. (ncats.io)
- Benzydamine is produced as a hydrochloride salt. (psychonautwiki.org)
- The aim of this study was to develop a vaginal delivery system for benzydamine hydrochloride (BNZ) loaded liposomes dispersed into mucoadhesive gels. (gazi.edu.tr)
- Commonly available mouthwash benzydamine hydrochloride is a nonsteroidal drug with proven topical anti-inflammatory, analgesic, anaesthetic, and antimicrobial activities. (icpahealth.com)
- A simple technique of gargling performed preoperatively with benzydamine hydrochloride was effective in reducing POST with no evidence of any side effects. (msjonline.org)
- Benzydamine hydrochloride for prophylaxis of radiation induced oral mucositis: results from a multicenter, randomized, double-blind, placebo-controlled clinical trial. (msjonline.org)
- Kati I, Tekin M, Silay E, Huseyinoglu UA, Yildiz H. Does benzydamine hydrochloride applied preemptively reduce sore throat due to laryngeal mask airway? (msjonline.org)
- The study tested magic mouthwash combined with another drug against benzydamine hydrochloride. (healthline.com)
- Alfa Aesar MSDS] See "Benzydamine hydrochloride. (nih.gov)
- Benzydamine hydrochloride: full subsidy would be available via prescription endorsement in the community for patients with oral mucositis resulting from cancer treatment. (pharmac.govt.nz)
- Effect of benzydamine hydrochloride spray on postoperative pain relief after tonsillectomy. (springer.com)
- Benzydamine Hydrochloride 3.00mg Cetylpyridinum Chloride 1.33mg. (netpharmacy.co.nz)
Mouthwash5
- Antimicrobial action of Nitens mouthwash (cetyltrimethylammonium naproxenate) on multiple isolates of pharyngeal microbes: a controlled study against chlorhexidine, benzydamine, hexetidine, amoxicillin, amoxicillin-clavulanate, clarithromycin, and cefaclor. (ncats.io)
- Benzydamine mouthwash along with traditional curcumin & honey can prevent or reduce the severity of oral mucositis. (icpahealth.com)
- Benzydamine mouthwash may be helpful. (bad.org.uk)
- Aloe vera mouthwash was as beneficial as benzydamine mouthwash in alleviating the severity of radiation-induced mucositis. (greenmedinfo.com)
- A topical analgesic (e.g. benzydamine mouthwash) may reduce pain. (pr.com)
0.151
- Group B patients received benzydamine 0.15% gargles while group C received placebo. (msjonline.org)
Mucositis6
- Benzydamine has been evaluated in patients with cancer for the prevention and management of mucositis. (ons.org)
- Moderate evidence suggested that benzydamine is effective in relieving mouth pain caused by radiation-induced mucositis in patients with head and neck cancer. (ons.org)
- We evaluated the efficacy of benzydamine oral rinse for prevention of radiation-induced mucositis. (unboundmedicine.com)
- or =2 mucositis was 24 days in the placebo group and 28 days in the benzydamine group (P = 0.12). (unboundmedicine.com)
- Benzydamine oral rinse seems to be effective, safe, and well tolerated for prophylactic treatment of radiation-induced oral mucositis in head and neck tumours. (unboundmedicine.com)
- Mucositis chlorhexidine or benzydamine mouthwashes. (norfolkspca.com)
Difflam3
- Difflam spray (benzydamine): how does it work? (netdoctor.co.uk)
- Difflam spray contains benzydamine, which is a non-steroidal anti-inflammatory drug (NSAID), it acts as an analgesic and anti-inflammatory treatment for the throat and mouth. (netdoctor.co.uk)
- Benzydamine (also known as Difflam or Tantum Verde ) is a topical anaesthetic of the indazole chemical class. (psychonautwiki.org)
Chlorhexidine2
- In a trial of chlorhexidine versus benzydamine, patients reported more discomfort with benzydamine and were more likely to discontinue participation in the trial. (ons.org)
- The medicines below all contain the following active ingredient(s): benzydamine + chlorhexidine. (healthdirect.gov.au)
Rinse6
- Benzydamine liquid is used as a mouth rinse or gargle to soothe sore areas in the mouth or throat. (canada.com)
- Benzydamine is a nonsteroidal anti-inflammatory drug that has been used in an oral rinse. (ons.org)
- Benzydamine is a topical analgesic (oral rinse/gel) used to relieve painful mouth and throat conditions such as mouth ulcers, sore gums and sore throat. (internationaldrugmart.com)
- Do not swallow Benzydamine oral rinse or gel. (internationaldrugmart.com)
- There are no known interactions between Benzydamine oral rinse/gel and other medicines. (internationaldrugmart.com)
- Patients with head and neck cancers, who were referred in 2004-2005, received an oral rinse of either benzydamine or placebo. (unboundmedicine.com)
Lidocaine3
- The medicines below all contain the following active ingredient(s): lidocaine (lignocaine) + benzydamine + dichlorobenzyl alcohol. (healthdirect.gov.au)
- Lozenges that relieve these symptoms contain substances such as lidocaine, bezocaine, benzydamine and flubiprofen. (news-medical.net)
- This contains benzydamine or lidocaine oral gel that numbs the pain over the ulcers. (news-medical.net)
Tantum Verde1
- Benzydamine (awso known as Tantum Verde and branded in some countries as Diffwam and Septabene), avaiwabwe as de hydrochworide sawt, is a wocawwy acting nonsteroidaw anti-infwammatory drug (NSAID) wif wocaw anaesdetic and anawgesic properties for pain rewief and anti-infwammatory treatment of infwammatory conditions of de mouf and droat . (appspot.com)
Analgesic1
- Benzydamine is a locally acting nonsteroidal anti-inflammatory drug with local anaesthetic and analgesic properties. (psychonautwiki.org)
Sore4
- For sore throats , benzydamine should be gargled, 15 mL (1 tablespoonful) every 1½ to 3 hours. (canada.com)
- Benzydamine is indicated as well for relief from pain and inflammatory conditions associated with sore throat or mouth sores caused by radiation therapy. (internationaldrugmart.com)
- The benzydamine group B had no evidence of sore throat at 24 hours duration whereas group C had 36% of patients who still complained sore throat. (msjonline.org)
- Is benzydamine gargle good for sore throat? (healthtap.com)
Propane gives benzydamine2
- Treatment of the enolate of this amide with 3-chloro-1-dimethylamkino propane gives benzydamine (5). (wikipedia.org)
- Treatment of de enowate of dis amide wif 3-chworo-1-dimedywamkino propane gives benzydamine ( 5 ). (appspot.com)
Effects of benzydamine2
- Similarly to the in vivo paradigm, also the electrophysiological effects of benzydamine were potentiated in slices from animals that had undergone cocaine and heroin self-administration. (psychonautwiki.org)
- demographic characteristics, drug use pattern (lifetime use, use in the past 30 days, frequency, and characteristics of use in the past month) and effects of benzydamine through the use of a questionnaire . (bvsalud.org)
Medication2
- Do not use this medication if you are allergic to benzydamine or any ingredients of the medication. (canada.com)
- If your physician has instructed or directed you to use Benzydamine medication in a regular schedule and you have missed a dose of this medicine, use it as soon as you remember. (internationaldrugmart.com)
Interactions1
- However, it is important to inform your doctor about the use of any other medications including non-prescription medications (over-the-counter medicines that may increase the effect of Benzydamine) and dietary supplements like vitamins, minerals and herbal, so that the doctor can warn you of any possible drug interactions. (internationaldrugmart.com)
Benzyl-indazole1
- Benzydamine, or 3-(1-benzylindazol-3-yl)oxy-N,N-dimethylpropan-1-amine, is a synthetic benzyl-indazole molecule. (psychonautwiki.org)
Vitro2
- Studies indicate that benzydamine has notable in vitro antibacterial activity and also shows synergism in combination with other antibiotics, especially tetracyclines, against antibiotic-resistant strains of Staphylococcus aureus and Pseudomonas aeruginosa. (wikipedia.org)
- Studies indicate dat benzydamine has notabwe in vitro antibacteriaw activity and awso shows synergism in combination wif oder antibiotics, especiawwy tetracycwines, against antibiotic-resistant strains of Staphywococcus aureus and Pseudomonas aeruginosa . (appspot.com)
Inflammation4
- Benzydamine reduces inflammation and pain in the area its's applied to. (netdoctor.co.uk)
- Benzydamine inhibits the synthesis of proinflammatory cytokines including tumour necrosis factor-α (TNF-α) and Interleukin-1β (IL-1β) w/o significantly affecting other proinflammatory (IL-6 and 8) or anti-inflammatory cytokines (IL-10, IL-1 receptor antagonist), thus reducing local pain and inflammation. (mims.com)
- Benzydamine(Amigdazol Nf) generic Tantum Vag Douche is a locally-acting non-steroidal anti-inflammatory drug, prescribed for painful musculoskeletal and soft tissue disorders and inflammation of the mouth and throat. (medindia.net)
- Benzydamine is also used to treat pain and inflammation following dental surgery. (internationaldrugmart.com)
Chloride1
- Alkylation of the enol with sodium methoxide and 3-dimethylaminopropyl chloride gives benzydamine. (wikipedia.org)
Mouth wash1
- The prescribed amount of Benzydamine should be used as a mouth wash around the mouth or as a gargle in the throat, for at least 30 seconds, and then it should be spit out. (internationaldrugmart.com)
Mouthwashes1
- According to the analysis of rank probabilities, chamomile, honey, curcumin, and benzydamine mouthwashes are the most beneficial in preventing intolerable OM. (icpahealth.com)
Vaginal2
- Vaginal Delivery of Benzydamine Hydrochl. (gazi.edu.tr)
- Studies of treatments (vaginal oestrogens, benzydamine douches, dilators, and intercourse) were neither recent nor good quality. (cochrane.org)
Numbness1
- Benzydamine also acts as a mild local anaesthetic, causing numbness and pain relief at the site of application. (netdoctor.co.uk)
Spray1
- Benzydamine spray is also available as the generic medicine. (netdoctor.co.uk)
Recreational5
- Alternatively, benzydamine can be used as a powerful psychoactive hallucinogen for recreational purposes. (psychonautwiki.org)
- The toxicity and long-term health effects of recreational benzydamine use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. (psychonautwiki.org)
- To describe the recreational use of benzydamine , an anti-inflammatory drug, among street youth in Brazil . (bvsalud.org)
- 78 reported lifetime recreational benzydamine use (67 cases identified only in three capitals). (bvsalud.org)
- This study identifies the recreational use of benzydamine among street youth , mainly in the Northeast of Brazil , and also indicates the need for special controls on the dispensation of this substance. (bvsalud.org)
Cytokines1
- When the cells were treated simultaneously with benzydamine and the cytokines IL-1beta or TNF-alpha, the agent benzydamine reduced (P (ncats.io)
Severity1
- The aim of the study was to evaluate the effectiveness of benzydamine preoperative gargles in reducing the incidence and severity of POST. (msjonline.org)
Dosage2
- What is the recommended dosage of Benzydamine? (internationaldrugmart.com)
- The dosage of Benzydamine prescribed to each patient will vary. (internationaldrugmart.com)
Patients1
- Nous avons comparé les effets de la vaporisation de chlorhydrate de benzydamine (CB), de lidocaïne 10 %, ou de solution saline sur la prévention des maux de gorge postopératoires chez les patients subissant une thyroïdectomie totale (TT). (springer.com)
Belongs1
- Benzydamine belongs to a group of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). (internationaldrugmart.com)
Sodium1
- Awkywation of de enow wif sodium medoxide and 3-dimedywaminopropyw chworide gives benzydamine. (appspot.com)
Overdose2
- What if you overdose on Benzydamine? (internationaldrugmart.com)
- If you suspect an overdose of Benzydamine, seek medical attention immediately. (internationaldrugmart.com)
Toxicity1
- Benzydamine reduces radiation-induced toxicity by suppressing selected pro-inflammatory cytokine production - one of the significant OM mechanisms. (icpahealth.com)
Doses1
- Anecdotal evidence from people within the psychonaut community who have tried benzydamine suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). (psychonautwiki.org)
Placebo1
- Benzydamine and indomethacin were no different from placebo. (bmj.com)
Findings3
- New pharmacologic and biochemical findings on the mechanism of action of the non-steroidal antiphlogistic, benzydamine. (wikipedia.org)
- Findings related to benzydamine were inconsistent. (ons.org)
- These findings provide firm evidence of the abuse liability of benzydamine and suggest a possible cannabinoidergic mechanism of action. (psychonautwiki.org)
Drugs2
- What other drugs could interact with Benzydamine? (internationaldrugmart.com)
- Benzydamine has a powerful reinforcing effect and that this effect is greatly facilitated in animals that already had substance experience, having previously self-administered heroin and cocaine , indicating cross sensitization between benzydamine and other common drugs of abuse. (psychonautwiki.org)
Treatments1
- For treatment associated with radiation therapy , benzydamine should be started the day before the start of radiation therapy and continued daily during the treatment period, as well as after the treatments have stopped, until there is improvement in the discomfort. (canada.com)