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BenztropineMazindolClopenthixolDopamine Plasma Membrane Transport ProteinsTropanesDopamine Uptake InhibitorsCocaineBenz(a)AnthracenesTabletsProtective DevicesDrug Information ServicesPatient CareDrug SubstitutionPharmacy Service, HospitalForensic PsychiatryJudgmentDiphenhydramineDictionaries, MedicalDictionaries as TopicDictionaries, ChemicalTerminology as TopicEmergenciesEmergency TreatmentEmergency MedicineEmergency Service, Hospital
Benztropine
A centrally active muscarinic antagonist that has been used in the symptomatic treatment of PARKINSON DISEASE. Benztropine also inhibits the uptake of dopamine.
Mazindol
Tricyclic anorexigenic agent unrelated to and less toxic than AMPHETAMINE, but with some similar side effects. It inhibits uptake of catecholamines and blocks the binding of cocaine to the dopamine uptake transporter.
Clopenthixol
A thioxanthene with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors.
Dopamine Plasma Membrane Transport Proteins
Sodium chloride-dependent neurotransmitter symporters located primarily on the PLASMA MEMBRANE of dopaminergic neurons. They remove DOPAMINE from the EXTRACELLULAR SPACE by high affinity reuptake into PRESYNAPTIC TERMINALS and are the target of DOPAMINE UPTAKE INHIBITORS.
Tropanes
N-methyl-8-azabicyclo[3.2.1]octanes best known for the ones found in PLANTS.
Dopamine Uptake Inhibitors
Drugs that block the transport of DOPAMINE into axon terminals or into storage vesicles within terminals. Most of the ADRENERGIC UPTAKE INHIBITORS also inhibit dopamine uptake.
Cocaine
An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.
Benz(a)Anthracenes
Four fused benzyl rings with three linear and one angular, that can be viewed as a benzyl-phenanthrenes. Compare with NAPHTHACENES which are four linear rings.
Tablets
Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)
Protective Devices
Devices designed to provide personal protection against injury to individuals exposed to hazards in industry, sports, aviation, or daily activities.
Drug Information Services
Services providing pharmaceutic and therapeutic drug information and consultation.
Patient Care
The services rendered by members of the health profession and non-professionals under their supervision.
Drug Substitution
The practice of replacing one prescribed drug with another that is expected to have the same clinical or psychological effect.
Pharmacy Service, Hospital
Hospital department responsible for the receiving, storing, and distribution of pharmaceutical supplies.
Forensic Psychiatry
Psychiatry in its legal aspects. This includes criminology, penology, commitment of mentally ill, the psychiatrist's role in compensation cases, the problems of releasing information to the court, and of expert testimony.
Judgment
The process of discovering or asserting an objective or intrinsic relation between two objects or concepts; a faculty or power that enables a person to make judgments; the process of bringing to light and asserting the implicit meaning of a concept; a critical evaluation of a person or situation.
Diphenhydramine
A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
Dictionaries, Medical
Dictionaries as Topic
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
Dictionaries, Chemical
Terminology as Topic
The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.
Emergencies
Situations or conditions requiring immediate intervention to avoid serious adverse results.
Emergency Treatment
First aid or other immediate intervention for accidents or medical conditions requiring immediate care and treatment before definitive medical and surgical management can be procured.
Emergency Medicine
The branch of medicine concerned with the evaluation and initial treatment of urgent and emergent medical problems, such as those caused by accidents, trauma, sudden illness, poisoning, or disasters. Emergency medical care can be provided at the hospital or at sites outside the medical facility.
Emergency Service, Hospital
Hospital department responsible for the administration and provision of immediate medical or surgical care to the emergency patient.

Developing hypothalamic dopaminergic neurones as potential targets for environmental estrogens. (1/48)

Environmental chemicals which mimic the actions of estrogen have the potential to affect any estrogen responsive tissue. The aim of the present study was to investigate their potential to mimic the effects of 17beta-estradiol (E2) on developing primary rat hypothalamic dopaminergic (DA) neurones maintained in a chemically defined medium. We now show that both E2 and octylphenol (OP), but not the non-aromatizable androgen, dihydrotestosterone, enhanced the uptake of [3H]DA by the cultured cells, whereas they had no effect on the uptake of [14C]GABA. Although the sensitivity of responses may change with the age of the developing cultures, the dose response curves for E2 and OP were typically 'bell-shaped', with a rise in response followed by a decline to control levels with increasing concentrations. Effects were seen as low as 10(-14) M for E2 and 10(-11) M for OP. Responses to E2 (10(-12) M) and OP (10(-9) M) were reversed in the presence of the antiestrogen, ZM 182780 (10(-5) M). This study thus provides direct evidence, using a mechanistic rather than toxicological end-point, in support of the hypothesis that inappropriate exposure to environmental estrogens at critically sensitive stages of development, could potentially perturb the organisational activities of estrogen on selected neuronal populations in the CNS.  (+info)

Behavioral and neurochemical effects of the dopamine transporter ligand 4-chlorobenztropine alone and in combination with cocaine in vivo. (2/48)

The current studies evaluated the novel diphenylmethoxytropane analog 4-chlorobenztropine (4-Cl-BZT), cocaine, and combinations of the two drugs for their abilities to stimulate locomotor activity, produce cocaine-like discriminative stimulus effects, and elevate extracellular dopamine (DA) in the nucleus accumbens (NAc) as measured by in vivo microdialysis. Peripherally administered cocaine was approximately twice as efficacious as 4-Cl-BZT as a locomotor stimulant and was behaviorally active at a lower dose than was 4-Cl-BZT. Cocaine also was more efficacious than 4-Cl-BZT in producing discriminative-stimulus effects in rats trained to discriminate i.p. injections of 10 mg/kg cocaine from saline. The time course of behavioral activation differed markedly between the two drugs, with much shorter onset and duration of locomotor stimulant effects for cocaine relative to 4-Cl-BZT. Similarly, i.p. cocaine (10 and 40 mg/kg) induced a pronounced, rapid, and short-lived increase in DA in the NAc, whereas i.p. 4-Cl-BZT was effective only at the higher dose and produced a more gradual, modest, and sustained (>/=2 h) elevation in accumbens DA. In contrast to i.p. administration, local infusion of 4-Cl-BZT (1-100 microM) into the NAc through the microdialysis probe elevated extracellular DA to a much greater extent than did local cocaine (nearly 2000% of baseline maximally for 4-Cl-BZT versus 400% of baseline for cocaine) and displayed a much longer duration of action than cocaine. However, when microinjected bilaterally into the NAc at 30 or 300 nmol/side, cocaine remained a more efficacious locomotor stimulant than 4-Cl-BZT. Finally, pretreatment with i.p. 4-Cl-BZT dose dependently enhanced the locomotor stimulant, discriminative stimulus effects, and NAc DA response to a subsequent low-dose i.p. cocaine challenge. The diphenylmethoxytropane analog also facilitated the emergence of stereotyped behavior and convulsions induced by high-dose cocaine. The current results demonstrate that DA transporter ligands that do not share the neurochemical and behavioral profiles of cocaine nevertheless may enhance the effects of cocaine in vivo.  (+info)

The uptake inhibitors cocaine and benztropine differentially alter the conformation of the human dopamine transporter. (3/48)

The binding affinity of the cocaine analog [(3)H]2 beta-carbomethoxy-3beta-(4-fluorophenyl) tropane (WIN) for the dopamine transporter (DAT) is increased by the reaction of Cys-90, at the extracellular end of the first transmembrane segment, with methanethiosulfonate (MTS) reagents. Cocaine enhances the reaction of Cys-90 with the sulfhydryl reagents, thereby augmenting the increase in binding. In contrast, cocaine decreases the reaction of Cys-135 and Cys-342, endogenous cysteines in cytoplasmic loops, with MTS reagents. Because this reaction inhibits [(3)H]WIN binding, cocaine protects against the loss of binding caused by reaction of these cysteines. In the present work, we compare the abilities of DAT inhibitors and substrates to affect the reaction of Cys-90, Cys-135, and Cys-342 with MTS ethyltrimethylammonium (MTSET). The results indicate that the different abilities of compounds to protect against the MTSET-induced inhibition of binding are attributable to differences in their abilities to attenuate the inhibitory effects of modification of Cys-135 and Cys-342 as well as to enhance the reaction with Cys-90 and the resulting potentiation of binding. The inhibitor benztropine was unique in its inability to protect Cys-135. Moreover, whereas cocaine, WIN, mazindol, and dopamine enhanced the reaction of Cys-90 with MTSET, benztropine had no effect on this reaction. These two features combine to give benztropine its weak potency in protecting ligand binding to wild-type DAT from MTSET. These results indicate that different inhibitors of DAT, such as cocaine and benztropine, produce different conformational changes in the transporter. There are differences in the psychomotor stimulant-like effects of these compounds, and it is possible that the different behavioral effects of these DAT inhibitors stem from their different molecular actions on DAT.  (+info)

Neuroleptic effects on autonomic activity in schizophrenia: between-group and within-subject paradigms and comparisons with controls. (4/48)

Effects of fluphenazine on electrodermal activity (EDA) and heart rate (HR) were studied in patients with schizophrenia and normal control subjects during rest periods, presentation of innocuous tones, and a reaction time (RT) task. Two types of analyses were used: (1) between-group analyses-patients taking placebo were compared with patients taking fluphenazine and with control subjects using only data from the first test session; and (2) within-subject analyses-the same patients were tested when taking fluphenazine and when taking placebo. Results showed higher resting EDA and HR and smaller increments to task performance in placebo patients than in control subjects. Fluphenazine attenuated EDA levels but not the tonic response. Fluphenazine attenuated the HR response but did not affect HR level. Placebo patients were electrodermally hyporesponsive to the RT stimuli but not to simple tones. Fluphenazine markedly attenuated responsivity to simple tones but it attenuated responsivity less for RT stimuli. Testing medicated patients may thus produce misleading results with respect to many, but not all, purported autonomic markers of diagnosis in schizophrenia studies.  (+info)

Gene expression deficits in a subclass of GABA neurons in the prefrontal cortex of subjects with schizophrenia. (5/48)

Markers of inhibitory neurotransmission are altered in the prefrontal cortex (PFC) of subjects with schizophrenia, and several lines of evidence suggest that these alterations may be most prominent in the subset of GABA-containing neurons that express the calcium-binding protein, parvalbumin (PV). To test this hypothesis, we evaluated the expression of mRNAs for PV, another calcium-binding protein, calretinin (CR), and glutamic acid decarboxylase (GAD67) in postmortem brain specimens from 15 pairs of subjects with schizophrenia and matched control subjects using single- and dual-label in situ hybridization. Signal intensity for PV mRNA expression in PFC area 9 was significantly decreased in the subjects with schizophrenia, predominantly in layers III and IV. Analysis at the cellular level revealed that this decrease was attributable principally to a reduction in PV mRNA expression per neuron rather than by a decreased density of PV mRNA-positive neurons. In contrast, the same measures of CR mRNA expression were not altered in schizophrenia. These findings were confirmed by findings from cDNA microarray studies using different probes. Across the subjects with schizophrenia, the decrease in neuronal PV mRNA expression was highly associated (r = 0.84) with the decrease in the density of neurons containing detectable levels of GAD67 mRNA. Furthermore, simultaneous detection of PV and GAD67 mRNAs revealed that in subjects with schizophrenia only 55% of PV mRNA-positive neurons had detectable levels of GAD67 mRNA. Given the critical role that PV-containing GABA neurons appear to play in regulating the cognitive functions mediated by the PFC, the selective alterations in gene expression in these neurons may contribute to the cognitive deficits characteristic of schizophrenia.  (+info)

Evaluation of the blood-brain barrier transport, population pharmacokinetics, and brain distribution of benztropine analogs and cocaine using in vitro and in vivo techniques. (6/48)

The N-substituted 3alpha-[bis(4'-fluorophenyl)methoxy]tropanes (AHN 2-003, AHN 1-055, AHN 2-005, and JHW 007) bind with high affinity to the dopamine transporter and inhibit dopamine uptake more potently than cocaine, but they demonstrate behavioral profiles in animal models of psychostimulant abuse that are unlike that of cocaine. The objective of this study was to characterize the in vitro permeability, brain distribution, and pharmacokinetics of the benztropine (BZT) analogs. Transport studies of cocaine and the BZT analogs (10-4 M) were conducted across bovine brain microvessel endothelial cells. Male Sprague-Dawley rats (approximately 300 g) were administered BZT analogs (10 mg/kg) or cocaine (5 mg/kg) via the tail vein. Blood and brain samples were collected over 36 h and assayed using UV-high-performance liquid chromatography. Transport of both AHN 1-055 (2.15 x 10-4 cm/s) and JHW 007 (2.83 x 10-4 cm/s) was higher (p < 0.05) than that of cocaine (1.63 x 10-4 cm/s). The volume of distribution (12.3-30.5 l/kg) of the analogs was significantly higher than cocaine (0.9 l/kg). The BZT analogs displayed a > or =8-fold higher elimination half-life (4.12-16.49 h) compared with cocaine (0.49 h). The brain-to-plasma partition coefficients were at least two-fold higher for the BZTs versus cocaine, except for AHN 2-003. The BZT analogs are highly permeable across the blood-brain barrier and possess a pharmacokinetic profile different from that of cocaine. These characteristics, in addition to their distinctive behavioral profiles, suggest that the BZT analogs may be promising candidates for the treatment of cocaine abuse.  (+info)

Effects of N-substituted analogs of benztropine: diminished cocaine-like effects in dopamine transporter ligands. (7/48)

Previous studies demonstrated that analogs of benztropine (BZT) possess high affinity for the dopamine transporter, inhibit dopamine uptake, but generally have behavioral effects different from those of cocaine. One hypothesis is that muscarinic-M(1) receptor actions interfere with cocaine-like effects. Several tropane-nitrogen substitutions of 4',4"-diF-BZT have reduced M(1) affinity compared with the CH(3)-analog (AHN 1-055; 3alpha-[bis-(4-fluorophenyl)methoxy]tropane). All of the compounds displaced [(3)H]WIN 35,428 (2beta-carbomethoxy-3beta-(4-fluorophenyl)tropane) binding with affinities ranging from 11 to 108 nM. Affinities at norepinephrine ([(3)H]nisoxetine) and serotonin ([(3)H]citalopram) transporters ranged from 457 to 4810 and 376 to 3260 nM, respectively, and at muscarinic M(1) receptors ([(3)H]pirenzepine) from 11.6 (AHN 1-055) to higher values, reaching 1030 nM for the other BZT-analogs. Cocaine and AHN 1-055 produced dose-related increases in locomotor activity in mice, with AHN 1-055 less effective than cocaine. The other compounds were ineffective in stimulating activity. In rats discriminating cocaine (29 micromol/kg i.p.) from saline, WIN 35,428 fully substituted for cocaine, whereas AHN 1-055 produced a maximal substitution of 79%. None of the other analogs fully substituted for cocaine. WIN 35,428 produced dose-related leftward shifts in the cocaine dose-effect curve, whereas selected BZT analogs produced minimal changes in the effects of cocaine. The results suggest that reducing M(1) affinity of 4',4"-diF-BZT with N-substitutions reduces effectiveness in potentiating the effects of cocaine. Furthermore, although the BZT-analogs bind with high affinity at the dopamine transporter, their behavioral effects differ from those of cocaine. These compounds have reduced efficacy compared with cocaine, a long duration of action, and may serve as leads for the development of medications to treat cocaine abuse.  (+info)

Analogue functional analysis of movements associated with tardive dyskinesia. (8/48)

We studied whether movements associated with tardive dyskinesia (TD) served operant functions in 2 men with developmental disabilities. We found that TD-related movements occurred more frequently in the alone and attention conditions and less frequently in control and demand conditions. Our findings suggest that TD-related movements may not be maintained by social reinforcers and that decreases in TD movements are possibly a result of engagement in activities that are incompatible with TD movements.  (+info)

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Questions I Bet Your Psychiatrist Never Asked You - Freud & FashionQuestions I Bet Your Psychiatrist Never Asked You - Freud & Fashion
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Edward Ahn - Research Output - Johns Hopkins UniversityEdward Ahn - Research Output - Johns Hopkins University
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Compound RecordCompound Record
Volume 46, Issue 5, September 2009, Pages: 1028-1033, D. Shobha, M. Adharvana Chari, K. Mukkanti and K. H. Ahn. Version of Record online : 2 SEP 2009, DOI: 10.1002/jhet.174. ...
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Drug Shortage Detail: Benztropine Mesylate InjectionDrug Shortage Detail: Benztropine Mesylate Injection
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Sentencing Law and Policy: Is It Ethical to Chemically Castrate a Child Sex Offender?Sentencing Law and Policy: Is It Ethical to Chemically Castrate a Child Sex Offender?
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Straight Out Of Line :.: Dah lama tak tulis blogStraight Out Of Line :.: Dah lama tak tulis blog
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Ahn Picks Up Mitchell Cancer AwardAhn Picks Up Mitchell Cancer Award
Mobile cancer researcher Dr. Erin Eun-Young Ahn has been named the recipient of the 2017 Mayer Mitchell Award for Excellence in Cancer Research. The award, announced December 7, 2017, is presented annually to a promising scientist at USA Mitchell Cancer Institute upon the recommendation of a faculty committee. It includes a $10,000 prize. The award was established in 2009 by USA Trustee Arlene Mitchell in memory of her late husband, Mayer Mitchell, a Mobile businessman, longtime USA trustee and formative figure in the establishment of MCI. Ahn, an associate professor of oncologic sciences at MCI, focuses her research on the regulation of gene expression in cancer development and progression, with a special interest in leukemia. In 2015, she was awarded a five-year $1.7 million R01 grant from the National Cancer Institute to study the role of the SON protein in the development of leukemia. Dr. Ahn discovered that the SON gene controls the behavior of the genetic material in cells and that the ...
http://www.southalabama.edu/departments/publicrelations/pressreleases/121317mitchellaward.html
Yuni Ahn for Shanghai Tang Lattice Jacquard North South ToteYuni Ahn for Shanghai Tang Lattice Jacquard North South Tote
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Edward Ahn, M.D.Edward Ahn, M.D.
Ahn, K.Ahn, K.
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Upcoming Relocation for Dr. Sam Ahn of AAC - Allergy Asthma Clinic LTDUpcoming Relocation for Dr. Sam Ahn of AAC - Allergy Asthma Clinic LTD
Congratulations to Dr. Ahn on his upcoming relocation to Northern California to be closer to his family. His last day with us will be June 30, 2017. We wish him all the best in this new phase of his life and career. Please see the front desk to arrange for transfer of care after June 30th to any of our other physicians.
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Credentials | Dr. Max Ahn, MD | Wynnewood, PA | UrologistCredentials | Dr. Max Ahn, MD | Wynnewood, PA | Urologist
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KoreaMedKoreaMed
Han SA , Park SK , Ahn SH , Son BH , Lee MH , Choi DH , Noh DY , Han W , Lee ES , Han SK , Kim LS , Jung Y , Kim KS , Suh YJ , Moon BI , Nam SJ , Noh WC , Lee JE , Kim SW , . ...
https://koreamed.org/articles/0096jbc/12/2
Table of Contents - January 15, 2001, 166 (2) | The Journal of ImmunologyTable of Contents - January 15, 2001, 166 (2) | The Journal of Immunology
Hae Won Sohn, Young Kee Shin, Im-Soon Lee, Young Mee Bae, Young Ho Suh, Min Kyung Kim, Tae Jin Kim, Kyeong Cheon Jung, Weon Seo Park, Chan-Sik Park, Doo Hyun Chung, Kwangseog Ahn, In Sun Kim, Young Hyeh Ko, Yung Jue Bang, Chul Woo Kim and Seong Hoe Park ...
https://www.jimmunol.org/content/166/2
Cancer Research and TreatmentCancer Research and Treatment
Meerim Park, Jung Woo Han, Seung Min Hahn, Jun Ah Lee, Joo-Young Kim, Sang Hoon Shin, Dong-Seok Kim, Hong In Yoon, Kyung Taek Hong, Jung Yoon Choi, Hyoung Jin Kang, Hee Young Shin, Ji Hoon Phi, Seung-Ki Kim, Ji Won Lee, Keon Hee Yoo, Ki Woong Sung, Hong Hoe Koo, Do Hoon Lim, Hyung Jin Shin, Hyery Kim, Kyung-Nam Koh, Ho Joon Im, Seung Do Ahn, Young-Shin Ra, Hee-Jo Baek, Hoon Kook, Tae-Young Jung, Hyoung Soo Choi, Chae-Yong Kim, Hyeon Jin Park, Chuhl Joo ...
https://www.e-crt.org/articles/search_result.php?term=author&f_name=Seung%20Do&l_name=Ahn
Radiation Oncology JournalRadiation Oncology Journal
Yong-Hyub Kim, Sang-Yun Song, Hyun-Jeong Shim, Woong-Ki Chung, Sung-Ja Ahn, Mee Sun Yoon, Jae-Uk Jeong, Ju-Young Song, Taek-Keun ...
https://www.e-roj.org/current/?vol=33&no=1
Radiation Oncology JournalRadiation Oncology Journal
Suzy Kim, Sung Whan Kim, Byoung Yong Shim, Chi Hong Kim, So Hyang Song, Meyung Im Ahn, Deog Gon Cho, Kyu Do Cho, Jinyoung Yoo, Hoon Kyo ...
https://www.e-roj.org/articles/search_result.php?term=author&f_name=%20Deog%20Gon&l_name=Cho
Clinical and Experimental Emergency Medicine :: CEEMClinical and Experimental Emergency Medicine :: CEEM
Joonghee Kim, Joon-Won Kang, Kyuseok Kim, Sang Il Choi, Eun Ju Chun, Yeo Goon Kim, Won Young Kim, Dong Woo Seo, Jonghwan Shin, Huijai Lee, Kwang-Nam Jin, Soyeon Ahn, Seung Sik Hwang, Kwang Pyo Kim, Ru-Bi Jeong, Sang Ook Ha, Byungho Choi, Chang-Hwan Yoon, Jung-Won Suh, Hack-Lyoung Kim, Ju Kyoung Kim, Sujin Jang, Ji Seon ...
http://ceemjournal.org/articles/search_result.php?term=author&f_name=Seung%20Sik&l_name=Hwang
Journal of Korean Neurosurgical SocietyJournal of Korean Neurosurgical Society
Joon Huh, Seo-Yeon Yang, Han-Yong Huh, Jae-Kun Ahn, Kwang-Wook Cho, Young-Woo Kim, Sung-Lim Kim, Jong-Tae Kim, Do-Sung Yoo, Hae-Kwan Park, Cheol ...
https://www.jkns.or.kr/specialties/?subspecialty=Vascular
Clinical and Experimental Emergency Medicine :: CEEMClinical and Experimental Emergency Medicine :: CEEM
Joonghee Kim, Joon-Won Kang, Kyuseok Kim, Sang Il Choi, Eun Ju Chun, Yeo Goon Kim, Won Young Kim, Dong Woo Seo, Jonghwan Shin, Huijai Lee, Kwang-Nam Jin, Soyeon Ahn, Seung Sik Hwang, Kwang Pyo Kim, Ru-Bi Jeong, Sang Ook Ha, Byungho Choi, Chang-Hwan Yoon, Jung-Won Suh, Hack-Lyoung Kim, Ju Kyoung Kim, Sujin Jang, Ji Seon ...
http://ceemjournal.org/articles/search_result.php?term=author&f_name=Kwang%20Pyo&l_name=Kim
Poly-sgRNA/siRNA ribonucleoprotein nanoparticles for targeted gene disruption. | Sigma-AldrichPoly-sgRNA/siRNA ribonucleoprotein nanoparticles for targeted gene disruption. | Sigma-Aldrich
Sigma-Aldrich offers abstracts and full-text articles by [Jong Seong Ha, Jae Sung Lee, Jaepil Jeong, Hejin Kim, Juyoung Byun, Sang Ah Kim, Hee Jae Lee, Hak Suk Chung, Jong Bum Lee, Dae-Ro Ahn].
https://www.sigmaaldrich.com/catalog/papers/28167287
methyl 2-amino-2-(3-fluorophenyl)acetate hydrochloride | CAS No. 42718-21-8 | Sigma-Aldrichmethyl 2-amino-2-(3-fluorophenyl)acetate hydrochloride | CAS No. 42718-21-8 | Sigma-Aldrich
methyl 2-amino-2-(3-fluorophenyl)acetate hydrochloride; CAS Number: 42718-21-8; Linear Formula: C9H11ClFNO2; find Key Organics / BIONET-KEY128003692 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich
https://www.sigmaaldrich.com/catalog/buildingblock/product/keyorganicsbionet/key128003692?lang=en®ion=US
List of compounds with carbon number 21List of compounds with carbon number 21
benztropine. 86-13-5 C21H25NO. octyloxycyanobiphenyl. 52364-73-5 ...
https://en.wikipedia.org/wiki/List_of_compounds_with_carbon_number_21
List of dopaminergic drugsList of dopaminergic drugs
... benztropine) • Bromantane • 2-Butyl-3-(p-tolyl)quinuclidine (BTQ) • BTS-74,398 • Bupropion (amfebutamone) • Ciclazindol • ...
https://en.wikipedia.org/wiki/List_of_dopaminergic_drugs
BenzatropineBenzatropine
... while the modified USAN is benztropine mesylate. The modified JAN is a hybrid form, benztropine mesilate. The misspelling ... "Benztropine (Cogentin) Use During Pregnancy". Drugs.com. Retrieved 9 April 2019. "The Top 300 of 2020". ClinCalc. Retrieved 11 ... Benzatropine (INN), known as benztropine in the United States and Japan, is a medication used to treat a type of movement ... "Benztropine Mesylate Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 9 April ...
https://en.wikipedia.org/wiki/Benzatropine
PharmacogenomicsPharmacogenomics
When benztropine was added they experienced blurry vision. After an additional five months, the patient was switched from ... Their treatment included a combination of ziprasidone, olanzapine, trazodone and benztropine. The patient experienced dizziness ...
https://en.wikipedia.org/wiki/Pharmacogenomics
PropofolPropofol
Schramm, BM; Orser, BA (2002). "Dystonic reaction to propofol attenuated by benztropine (Cogentin)". Anesth Analg. 94 (5): 1237 ...
https://en.wikipedia.org/wiki/Propofol
بازدارنده آنزیم - ویکی‌پدیا، دانشنامهٔ آزادبازدارنده آنزیم - ویکی‌پدیا، دانشنامهٔ آزاد
Benztropine) • بنزیدامین • BIBN 99 • بی‌پریدن • Bornaprine • CAR-226,086 • CAR-301,060 • CAR-302,196 • CAR-302,282 • CAR- ... Benztropine) • Bepotastine • Bromazine • Brompheniramine • بوکلیزین • Captodiame • Carbinoxamine • Chlorcyclizine • ...
https://fa.wikipedia.org/wiki/بازدارنده_آنزیم
List of cocaine analoguesList of cocaine analogues
SARs have shown that 4′,4′-difluorination is an excellent way to boost DAT activity of benztropine, and gives excellent ... AHN 1-055 Same structure as for benztropine but 4′,4′-bisfluorinated. GA 103 N-phenylpropyl bis-4-fluorobenztropine. JHW 007 N ... This is remarkable considering unmodified (native) benztropine is 60 times more active as an anticholinergic than as a ... M1 receptor considerations aside, analogues of this benztropine class still won't substitute for cocaine, and have no ...
https://en.wikipedia.org/wiki/List_of_cocaine_analogues
HyperhidrosisHyperhidrosis
Other anticholinergic agents that have tried to include propantheline bromide and benztropine.[citation needed] Injections of ...
https://en.wikipedia.org/wiki/Hyperhidrosis
Typical antipsychoticTypical antipsychotic
Anticholinergics such as benztropine and diphenhydramine are commonly prescribed to treat the EPS. 4% of users develop rabbit ...
https://en.wikipedia.org/wiki/Typical_antipsychotic
Reuptake inhibitorReuptake inhibitor
Benztropine, mazindol, and vanoxerine also bind to these sites and have similar properties. In addition to their high affinity ...
https://en.wikipedia.org/wiki/Reuptake_inhibitor
CPCACPCA
For example, muscarinic activity of benztropine analogs is known to limit their reinforcing potential. Ion-channel activity is ...
https://en.wikipedia.org/wiki/( )-CPCA
VanoxerineVanoxerine
"Dopamine transport inhibitors based on GBR12909 and benztropine as potential medications to treat cocaine addiction". ...
https://en.wikipedia.org/wiki/Vanoxerine
JWH-007JWH-007
Another drug similarly named JHW-007 (not JWH) is a cocaine analog (the di-para-fluoro benztropine, being essentially a hybrid ... "Dopamine transport inhibitors based on GBR12909 and benztropine as potential medications to treat cocaine addiction". ...
https://en.wikipedia.org/wiki/JWH-007
டோம்பரிடோன் - தமிழ் விக்கிப்பீடியாடோம்பரிடோன் - தமிழ் விக்கிப்பீடியா
Benztropine) • Bromantane • BTQ • BTS-74,398 • Bupropion (Amfebutamone) • Ciclazindol • Diclofensine • Dimethocaine • ...
https://ta.wikipedia.org/wiki/டோம்பரிடோன்
DoxepinDoxepin
... also may potentiate the adverse effects of anticholinergic agents such as benztropine, atropine and hyoscine ( ...
https://en.wikipedia.org/wiki/Doxepin
ToxidromeToxidrome
... benztropine, datura, and scopolamine. The symptoms of a cholinergic toxidrome include bronchorrhea, confusion, defecation, ...
https://en.wikipedia.org/wiki/Toxidrome
ChlorpromazineChlorpromazine
Consuming food prior to taking chlorpromazine orally limits its absorption, likewise cotreatment with benztropine can also ...
https://en.wikipedia.org/wiki/Chlorpromazine
DystoniaDystonia
... benztropine), which act as inhibitors of the neurotransmitter acetylcholine, may provide some relief. In the case of an acute ...
https://en.wikipedia.org/wiki/Dystonia
DifluoropineDifluoropine
It is structurally related to benztropine and has similar anticholinergic and antihistamine effects in addition to its dopamine ...
https://en.wikipedia.org/wiki/Difluoropine
ModafinilModafinil
Aside from modafinil, examples of other atypical DAT inhibitors include vanoxerine and benztropine, which have a relatively low ...
https://en.wikipedia.org/wiki/Modafinil
AnticholinergicAnticholinergic
Examples of common anticholinergics: Antimuscarinic agents Atropine Benztropine (Cogentin) Biperiden Chlorpheniramine (Chlor- ...
https://en.wikipedia.org/wiki/Anticholinergic
Queensland Ambulance ServiceQueensland Ambulance Service
... benztropine, etc.). In addition to standard CCP skills, officers on the High Acute Response Unit (HARU) perform general ...
https://en.wikipedia.org/wiki/Queensland_Ambulance_Service
Extrapyramidal symptomsExtrapyramidal symptoms
The treatment varies by the type of the EPS, but may involve anticholinergic agents such as procyclidine, benztropine, ...
https://en.wikipedia.org/wiki/Extrapyramidal_symptoms
Albert KurlandAlbert Kurland
His investigations of haloanisone, pyridoxine, and perphenazine-benztropine mesylate, are examples of the broad range of ...
https://en.wikipedia.org/wiki/Albert_Kurland
Benzhydryl compoundsBenzhydryl compounds
... benztropine, deptropine, etybenzatropine, difluoropine Piperidine: diphenylpyraline Phthalane: talopram, citalopram Octahedral ...
https://en.wikipedia.org/wiki/Benzhydryl_compounds
Spasmodic dysphoniaSpasmodic dysphonia
A number of medications have also been tried including anticholinergics (such as benztropine) which have been found to be ...
https://en.wikipedia.org/wiki/Spasmodic_dysphonia
List of MeSH codes (D03)List of MeSH codes (D03)
... benztropine MeSH D03.132.889.354 - cocaine MeSH D03.132.889.354.250 - crack cocaine MeSH D03.132.889.848 - scopolamine MeSH ... benztropine MeSH D03.605.869.388 - cocaine MeSH D03.605.869.388.250 - crack cocaine MeSH D03.605.869.744 - nortropanes MeSH ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D03)
Management of cerebral palsyManagement of cerebral palsy
... including botulinum toxin A and benztropine and glycopyrrolate. Bisphosphonates are used to treat osteoporosis in adults. ...
https://en.wikipedia.org/wiki/Management_of_cerebral_palsy
ZuclopenthixolZuclopenthixol
... though in the short-term an anticholinergic medication benztropine may be helpful for tremor and stiffness, while diazepam may ...
https://en.wikipedia.org/wiki/Zuclopenthixol
List of phenyltropanesList of phenyltropanes
... or benztropine class (such as Difluoropine: which is extremely close to fitting the criteria of being a phenyltropane.) Whereas ... benztropine and others are in suchwise not considered "cocaine-like" and are instead considered atypical inhibitors insofar as ...
https://en.wikipedia.org/wiki/List_of_phenyltropanes
Benztropine: MedlinePlus Drug InformationBenztropine: MedlinePlus Drug Information
Benztropine: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Benztropine may make your skin sensitive to sunlight.. *talk to your doctor about the risks and benefits of taking benztropine ... Before taking benztropine,. *tell your doctor and pharmacist if you are allergic to benztropine, any other medications, or any ... Benztropine comes as a tablet to take by mouth. It usually is taken at bedtime. It is usually taken once daily but may be taken ...
https://medlineplus.gov/druginfo/meds/a682155.html
BenztropineBenztropine
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
https://webbook.nist.gov/cgi/cbook.cgi?ID=C86135&Units=SI&Mask=2000
Benztropine injectionBenztropine injection
BENZTROPINE (BENZ troe peen) is for certain movement problems due to Parkinsons disease, certain medicines, or other causes. ... Benztropine injection. What is this medicine?. BENZTROPINE (BENZ troe peen) is for certain movement problems due to Parkinsons ... an unusual or allergic reaction to benztropine, other medicines, lactose, foods, dyes, or preservatives ...
https://www.nationwidechildrens.org/family-resources-education/family-resources-library/benztropine-injection
DailyMed - BENZTROPINE MESYLATE injectionDailyMed - BENZTROPINE MESYLATE injection
Benztropine Mesylate (UNII: WMJ8TL7510) (Benztropine - UNII:1NHL2J4X8K) Benztropine Mesylate. 1 mg in 1 mL. ... BENZTROPINE MESYLATE injection. To receive this label RSS feed. Copy the URL below and paste it into your RSS Reader ... Benztropine Mesylate Injection, USP 1 mg per mL, is a clear, colorless solution and is supplied as follows: NDC 17478-012-02 in ... BENZTROPINE MESYLATE injection. If this SPL contains inactivated NDCs listed by the FDA initiated compliance action, they will ...
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=57107a07-3347-4eac-8d3e-7d5e0c0a2974&audience=consumer
DailyMed - BENZTROPINE MESYLATE tabletDailyMed - BENZTROPINE MESYLATE tablet
BENZTROPINE MESYLATE tablet. To receive this label RSS feed. Copy the URL below and paste it into your RSS Reader application. ... BENZTROPINE MESYLATE tablet. If this SPL contains inactivated NDCs listed by the FDA initiated compliance action, they will be ... Benztropine Mesylate Tablets USP are available as:. 0.5 mg: White, round, flat-faced, beveled edge, scored tablet. Debossed ... One to 2 mg of Benztropine Mesylate Tablets two or three times a day usually provides relief within one or two days. After one ...
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=7ea53a18-71d1-445b-b108-5d23bcd3bf24&audience=consumer
Prescriber Checkup | BENZTROPINE MESYLATEPrescriber Checkup | BENZTROPINE MESYLATE
Prescriber Checkup » BENZTROPINE MESYLATE BENZTROPINE MESYLATE. Cogentin (benztropine) blocks acetylcholine in the brain and ... Top prescribers for BENZTROPINE MESYLATE. 1 2 3 4 5 … Next › Last » ...
https://projects.propublica.org/checkup/drugs/2684?by=desc&sort=city
BENZTROPINE MESYLATE (injection) | Dosage and Administration | Healthgrades.comBENZTROPINE MESYLATE (injection) | Dosage and Administration | Healthgrades.com
The appearance of Benztropine Mesylate can differ based on the dosing. ... BENZTROPINE MESYLATE (injection) comes in different strengths and amounts. ...
https://www.healthgrades.com/drugs/benztropine-mesylate-injection/dosage
Benztropine: Pediatric Medication | Memorial Sloan Kettering Cancer CenterBenztropine: Pediatric Medication | Memorial Sloan Kettering Cancer Center
Benztropine Omega; Kynesia; PMS-Benztropine. What is this drug used for?. *It is used to treat side effects caused by some ...
https://www.mskcc.org/cancer-care/patient-education/benztropine
Benztropine Tablets: Indications, Side Effects, Warnings - Drugs.comBenztropine Tablets: Indications, Side Effects, Warnings - Drugs.com
Easy to read patient leaflet for Benztropine Tablets. Includes indications, proper use, special instructions, precautions, and ... For all patients taking this medicine (benztropine tablets): *If you have an allergy to benztropine or any other part of this ... How is this medicine (Benztropine Tablets) best taken?. Use this medicine (benztropine tablets) as ordered by your doctor. Read ... What are some things I need to know or do while I take Benztropine Tablets?. *Tell all of your health care providers that you ...
https://www.drugs.com/cdi/benztropine-tablets.html
803866: Benztropine, Serum or Plasma | LabCorp803866: Benztropine, Serum or Plasma | LabCorp
2019 Laboratory Corporation of America® Holdings and Lexi-Comp Inc. All Rights Reserved.. CPT Statement/Profile Statement. The LOINC® codes are copyright © 1994-2018, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf. ...
https://www.labcorp.com/test-menu/37511/benztropine-serum-or-plasma
Benztropine (Injection Route) Description and Brand Names - Mayo ClinicBenztropine (Injection Route) Description and Brand Names - Mayo Clinic
Benztropine injection is used with other medicines to treat Parkinsons disease. By improving muscle control and reducing ...
https://www.mayoclinic.org/drugs-supplements/benztropine-injection-route/description/drg-20072673
Acetaminophen / chlorpheniramine / dextromethorphan and benztropine Drug Interactions - Drugs.comAcetaminophen / chlorpheniramine / dextromethorphan and benztropine Drug Interactions - Drugs.com
... dextromethorphan and benztropine. View detailed information regarding this drug interaction. ... Using benztropine together with chlorpheniramine may increase side effects such as drowsiness, blurred vision, dry mouth, heat ... Using benztropine together with dextromethorphan may increase side effects such as dizziness, drowsiness, confusion, and ... Drug Interactions between acetaminophen / chlorpheniramine / dextromethorphan and benztropine. This report displays the ...
https://www.drugs.com/drug-interactions/acetaminophen-chlorpheniramine-dextromethorphan-with-benztropine-37-0-363-0.html
Drug Shortage Detail: Benztropine Mesylate InjectionDrug Shortage Detail: Benztropine Mesylate Injection
Benztropine Mesylate Injection. Reason for the Shortage. * *American Regent discontinued benztropine injection in May 2015. ... Benztropine Mesylate injection, Fresenius Kabi, 1 mg/mL, 2 mL vial, 5 count, NDC 63323-0970-02 ... Benztropine Mesylate injection, West-Ward, 1 mg/mL, 2 mL ampule, 5 count, NDC 00143-9729-05 ... Benztropine Mesylate injection, Akorn, 1 mg/mL, 2 mL ampule, 5 count, NDC 17478-0012-02 ...
https://www.ashp.org/Drug-Shortages/Current-Shortages/Drug-Shortage-Detail.aspx?id=49
BenztropineBenztropine
DESCRIPTION Benztropine mesylate is a synthetic compound containing structural features found in atropine and diphenhydramine. ... Benztropine mesylate is a synthetic compound containing structural features found in atropine and diphenhydramine. It is a ... Molecular weight: 403.55 Each tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg of benztropine mesylate. Each ...
http://www.egeneralmedical.com/rxlist00000726.html
benztropine - WellSpan Health Librarybenztropine - WellSpan Health Library
Benztropine is used together with other medicines to treat the symptoms of Parkinsons disease (muscle spasms, stiffness, ... Benztropine reduces the effects of certain chemicals in the body that may be unbalanced as a result of disease (such as ... What is benztropine?. Benztropine reduces the effects of certain chemicals in the body that may be unbalanced as a result of ... What is the most important information I should know about benztropine?. Benztropine is not approved for use by anyone younger ...
https://www.wellspan.org/health-library/Document.aspx?id=d00175a1
Cogentin (benztropine) Uses, Side Effects, Dosage & InteractionsCogentin (benztropine) Uses, Side Effects, Dosage & Interactions
... benztropine) includes side effects, uses, drug interactions, dosage, drug pictures, overdose symptoms, and what to avoid. ... You should not use benztropine if you are allergic to it.. Benztropine is not approved for use by anyone younger than 3 years ... Using benztropine during pregnancy could harm the unborn baby. Tell your doctor if you are pregnant or if you become pregnant ... Benztropine is also used to treat and prevent these symptoms when they are caused by drugs such as chlorpromazine (Thorazine), ...
https://www.emedicinehealth.com/drug-benztropine/article_em.htm
Apo-Benztropine - Uses, Side Effects, Interactions - MedBroadcast.comApo-Benztropine - Uses, Side Effects, Interactions - MedBroadcast.com
Apo-Benztropine: This medication belongs to the class of medications called antiparkinsonians. It is used to treat the symptoms ... The recommended adult dose of benztropine is usually 1 mg to 2 mg daily, although the dose can range from 0.5 mg to 6 mg daily ... Benztropine can be taken with or without food.. Many things can affect the dose of medication that a person needs, such as body ... Children: Benztropine should not be taken by children under 3 years of age. Children over 3 years of age should be monitored by ...
https://medbroadcast.com/drug/getdrug/apo-benztropine
Benztropine - International Hyperhidrosis Society | Official SiteBenztropine - International Hyperhidrosis Society | Official Site
A search of the medical literature using PubMed, however, found no further recent published reports of Benztropine in the ... socially disabling generalized hyperhidrosis on venlafaxine responded to use of the anticholinergic benztropine 0.5 mg twice a ...
https://www.sweathelp.org/treatments-hcp/systemic-medication/benztropine-for-hyperhidrosis-associated-with-venlafaxine-use.html
Drug info - - Benztropine | Drugs-ForumDrug info - - Benztropine | Drugs-Forum
Drug info - Benztropine Discussion in Various drugs not covered by other forums started by Riconoen {UGC}, Oct 27, 2006. ... Using benztropine for a runny nose would be the equivalent of using a body-cast for a paper-cut. Get some DayQuil. Geesh! ... As benztropine is an anticholinergic and antihistamine, recreational use or taking more than the reccomended dose is ... Paradoxically, benztropine is given to people on extended dosage plans involving phenothiazines used for psychosis. This being ...
https://drugs-forum.com/threads/benztropine.24544/
Extrapyramidal side effects in chlorpromazine recipients: emergence according to benztropine prophylaxis.Extrapyramidal side effects in chlorpromazine recipients: emergence according to benztropine prophylaxis.
... attributed to chlorpromazine among 86 patients who received benztropine for the prevention of EPS (9.3%) was similar to that of ... Benztropine / therapeutic use*. Chlorpromazine / administration & dosage, adverse effects*. Drug Therapy, Combination. Female. ... 0/Tropanes; 50-53-3/Chlorpromazine; 86-13-5/Benztropine From MEDLINE®/PubMed®, a database of the U.S. National Library of ... The frequency of extrapyramidal symptoms (EPS) attributed to chlorpromazine among 86 patients who received benztropine for the ...
http://www.biomedsearch.com/nih/Extrapyramidal-side-effects-in-chlorpromazine/889418.html
Apo-Benztropine | definition of Apo-Benztropine by Medical dictionaryApo-Benztropine | definition of Apo-Benztropine by Medical dictionary
Apo-Benztropine explanation free. What is Apo-Benztropine? Meaning of Apo-Benztropine medical term. What does Apo-Benztropine ... Looking for online definition of Apo-Benztropine in the Medical Dictionary? ... benztropine mesylate. (redirected from Apo-Benztropine) benztropine mesylate. Apo-Benztropine (CA), Cogentin, PMS Benztropine ( ... Drug-drug. Antacids, antidiarrheals: decreased benztropine absorption. Antihistamines, bethanechol, disopyramide, ...
https://medical-dictionary.thefreedictionary.com/Apo-Benztropine
Benztropine (By injection) | Lima Memorial Health SystemBenztropine (By injection) | Lima Memorial Health System
Benztropine (By injection). Benztropine (BENZ-troe-peen). Treats symptoms of Parkinson disease or side effects of other drugs. ... Do not receive it if you had an allergic reaction to benztropine.. How to Use This Medicine: Injectable. *A nurse or other ... Some foods and medicines may affect how benztropine works. Tell your doctor if you are taking any of the following: * ...
https://www.limamemorial.org/health-library/Thomson%20DrugNotes/45/4999
Leki refundowane - Cena i zamienniki leku Benztropine MesylateLeki refundowane - Cena i zamienniki leku Benztropine Mesylate
Sprawdź ile zapłacisz za lek Benztropine Mesylate w aptece, znajdź tańsze zamienniki leku. Określ swoje uprawnienia i sprawdź ...
http://leki-refundowane.com/leki/benztropine-mesylate.htm
Benztropine mesylate (By mouth) | Lima Memorial Health SystemBenztropine mesylate (By mouth) | Lima Memorial Health System
Benztropine mesylate (By mouth). Benztropine Mesylate (BENZ-troe-peen MES-i-late). Treats symptoms of Parkinsons disease or ... Benztropine may be taken with or without food. *Measure the oral liquid medicine with a marked measuring spoon, oral syringe, ... You should not use this medicine if you have had an allergic reaction to benztropine. This medicine should not be taken by ...
http://www.limamemorial.org/health-library/Thomson%20DrugNotes/45/0383
benztropine mesylate 0.5 MG Oral Tablet | Semantic Scholarbenztropine mesylate 0.5 MG Oral Tablet | Semantic Scholar
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CogentinTroe peenAnticholinergicChlorpromazineSave on Benztropine MesylateTabletMedicationsAtropineMesilateTake benztropineDrugsParkinson'sBenzatropineMedicines2018DiphenhydramineHallucinationsPotent dopamineMedication prescribedDosageSide effectsDrugTardiveDopamineAnalogsMethanesulfonate2016Healthcare providerAnticholinergicsDoseMedicineDrowsinessPrecautionsAntiparkinsonianTabletsPatientsPregnancyBreast milkNortriptylineRelieveSearch
Cogentin8
  • Cogentin (benztropine) blocks acetylcholine in the brain and smooth muscles which stops spasming and calms tremors. (propublica.org)
  • What is benztropine (Cogentin)? (emedicinehealth.com)
  • What are the possible side effects of benztropine (Cogentin)? (emedicinehealth.com)
  • What is the most important information I should know about benztropine (Cogentin)? (emedicinehealth.com)
  • Does Cogentin (Benztropine Mesylate) Get You High? (recoveryfirst.org)
  • Cogentin, or benztropine mesylate, is a medication that is often prescribed to treat symptoms caused by Parkinson's disease in combination with other prescription drugs. (recoveryfirst.org)
  • Cogentin (benztropine) is an antiparkinsonian drug in a class of drugs called anticholinergics. (verywellmind.com)
  • Many people being treated for Parkinson's disease or the Parkinsonian side effects of antipsychotics and many nurses of doctors treating them all the way back to the 1970s will know about benztropine - perhaps by its trade name Cogentin. (rxisk.org)
Troe peen1
  • BENZTROPINE (BENZ troe peen) is for certain movement problems due to Parkinson's disease, certain medicines, or other causes. (nationwidechildrens.org)
Anticholinergic8
  • Benztropine mesylate injection, USP possesses both anticholinergic and antihistaminic effects, although only the former have been established as therapeutically significant in the management of parkinsonism. (nih.gov)
  • When benztropine mesylate injection, USP is given concomitantly with phenothiazines, haloperidol, or other drugs with anticholinergic or antidopaminergic activity, patients should be advised to report gastrointestinal complaints, fever or heat intolerance promptly. (nih.gov)
  • Paralytic ileus, hyperthermia and heat stroke, all of which have sometimes been fatal, have occurred in patients taking anticholinergic-type antiparkinsonism drugs, including benztropine mesylate injection, in combination with phenothiazines and/or tricyclic antidepressants. (nih.gov)
  • 39 ] A woman who had severe, socially disabling generalized hyperhidrosis on venlafaxine responded to use of the anticholinergic benztropine 0.5 mg twice a day. (sweathelp.org)
  • As benztropine is an anticholinergic and antihistamine , recreational use or taking more than the reccomended dose is potentially dangerous and not reccomended. (drugs-forum.com)
  • Benztropine, a synthetic drug with anticholinergic, antihistaminic, and sedative actions, was administered by mouth to 302 patients with various forms of Parkinsonism. (jamanetwork.com)
  • A team at Scripps Research Institute a little over a year ago reported that benztropine had some extraordinarily interesting properties - nothing to do with its anticholinergic actions. (rxisk.org)
  • comments from anyone outside the US whose benztropine was stopped and finds they have developed new complaints since it was replaced by another anticholinergic. (rxisk.org)
Chlorpromazine4
  • Benztropine is also used to treat and prevent these symptoms when they are caused by drugs such as chlorpromazine (Thorazine), fluphenazine (Prolixin), perphenazine (Trilafon), and others. (wellspan.org)
  • Extrapyramidal side effects in chlorpromazine recipients: emergence according to benztropine prophylaxis. (biomedsearch.com)
  • Benztropine is used to treat symptoms of Parkinson's disease or involuntary movements due to the side effects of certain psychiatric drugs (antipsychotics such as chlorpromazine/haloperidol). (ndclist.com)
  • Amifampridine Amitriptyline Amoxapine Atropine Belladonna Benztropine Biperiden Brompheniramine Carbinoxamine Carisoprodol Chlorpheniramine Chlorpromazine Clemastine Clidinium Clomipramine Clozapine Cyclobenzaprine Cyclopentolate Cyp. (mayoclinic.org)
Save on Benztropine Mesylate1
Tablet4
  • Benztropine comes as a tablet to take by mouth. (medlineplus.gov)
  • Molecular weight: 403.55 Each tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg of benztropine mesylate. (egeneralmedical.com)
  • Each round, white, flat-faced, bevelled-edged, double-scored tablet marked 'APO' and '2' on one side contains 2 mg of benztropine. (medbroadcast.com)
  • It is a crystalline white powder, very soluble in water, designated as 3α-(Diphenylmethoxy)-1αH, 5αH-tropane methanesulfonate, with the following structural formula: Each tablet, for oral administration, contains 0.5 mg, 1 mg or 2 mg of benztropine mesylate. (seniorhealthcarematters.com)
Medications6
  • Benztropine is in a class of medications called anticholinergics. (medlineplus.gov)
  • Do not stop taking benztropine suddenly without talking with your doctor, especially if you are also taking other medications. (medlineplus.gov)
  • tell your doctor and pharmacist if you are allergic to benztropine, any other medications, or any of the ingredients in the benztropine preparation. (medlineplus.gov)
  • Older adults should not usually take benztropine because it is not as safe or effective as other medications that can be used to treat the same condition. (medlineplus.gov)
  • Benztropine can potentially interact with several medications (see Drug Interactions With Benztropine ) . (emedtv.com)
  • Psychiatric Medications: Benztropine. (verywellmind.com)
Atropine4
  • Benztropine mesylate is a synthetic compound containing structural features found in atropine and diphenhydramine. (nih.gov)
  • Since benztropine mesylate injection contains structural features of atropine, it may produce anhidrosis. (nih.gov)
  • Benztropine mesylate USP is a synthetic compound resulting from the combination of the active portions of atropine and diphenhydramine. (nih.gov)
  • Benztropine is a synthetic compound derived from the combination of atropine and diphenhydramine that acts centrally to antagonize M1 muscarinic acetylcholine receptors. (invivochem.com)
Mesilate2
  • Both names may be modified to account for the methanesulfonate salt as which the medication is formulated: the modified INN (INNm) and BAN (BANM) is benzatropine mesilate, while the modified USAN is benztropine mesylate. (wikipedia.org)
  • The modified JAN is a hybrid form, benztropine mesilate. (wikipedia.org)
Take benztropine6
  • Take benztropine at around the same time(s) every day. (medlineplus.gov)
  • Take benztropine exactly as directed. (medlineplus.gov)
  • What do I need to tell my doctor BEFORE I take Benztropine Tablets? (drugs.com)
  • What are some things I need to know or do while I take Benztropine Tablets? (drugs.com)
  • How should I take benztropine? (wellspan.org)
  • It is best to take benztropine at bedtime, especially if you take this medicine only once per day. (wellspan.org)
Drugs6
  • This is not a list of all drugs or health problems that interact with this medicine (benztropine tablets). (drugs.com)
  • Very bad bowel block (paralytic ileus), fever, and heat stroke have happened when this medicine (benztropine tablets) was taken along with certain other drugs. (drugs.com)
  • There are 2 terms under the parent term 'Benztropine' in the ICD-10-CM Drugs Index . (icd.codes)
  • Benztropine mesylate is used to treat the symptoms of Parkinson's disease and tremors caused by other medical problems or drugs.This medication is sometimes prescribed fo. (ndclist.com)
  • BuyCancerDrugsOnline.com is your convenient and affordable mail order pharmacy broker delivering savings of 35% to 80% on Benztropine Mesylate as well as other cancer and non-cancer drugs from licensed Canadian and International pharmacies. (canadapharmacydirectory.com)
  • Taking a different approach to everyone else, the Scripps team screened banks of old drugs to see if anything has an effect on oligodendrocytes and to their surprise found that benztropine did. (rxisk.org)
Parkinson's5
  • Benztropine injection is used with other medicines to treat Parkinson's disease. (mayoclinic.org)
  • Benztropine reduces the effects of certain chemicals in the body that may be unbalanced as a result of disease (such as Parkinson's), drug therapy, or other causes. (wellspan.org)
  • Benztropine is used together with other medicines to treat the symptoms of Parkinson's disease (muscle spasms, stiffness, tremors, poor muscle control). (wellspan.org)
  • Benztropine has been used in the treatment of Parkinson's disease symptoms to address involuntary tremor and dystonia. (invivochem.com)
  • Benztropine (3.0 mg/day) is effective in improving tremor and the motor score of the United Parkinson's Disease Rating Scale without adverse events like leukopenia. (invivochem.com)
Benzatropine1
  • Benzatropine (INN), known as benztropine in the United States and Japan, is a medication used to treat a type of movement disorder due to antipsychotics known as dystonia and parkinsonism. (wikipedia.org)
Medicines1
20182
  • Benztropine Mesylate Market Insights 2018, is a professional and in-depth study on the current state of the global Benztropine Mesylate industry with a focus on the Global market. (themarketplan.com)
  • Overall, the report provides an in-depth insight of 2018-2024 global and Chinese Benztropine Mesylate market covering all important parameters. (themarketplan.com)
Diphenhydramine1
  • The most commonly used agents are benztropine and diphenhydramine. (medscape.com)
Hallucinations4
  • Benztropine can cause hallucinations (seeing, hearing, or feeling things that are not really there) or other psychological problems. (emedtv.com)
  • Let your healthcare provider know if you develop hallucinations while taking benztropine. (emedtv.com)
  • What causes hallucinations while on Amantadine and Benztropine? (healthcaremagic.com)
  • My doctor has finally responded with a new drug after Benztropine 1mg made me nauseated and caused hallucinations . (healthcaremagic.com)
Potent dopamine2
  • Benztropine (BZT) is a potent dopamine uptake inhibitor that is not subject to significant abuse in humans ( Rothman, 1990 ). (aspetjournals.org)
  • Benztropine is a highly potent dopamine transporter (DAT) inhibitor with IC50 of 118 nM. (invivochem.com)
Medication prescribed1
  • Why is benztropine mesylate oral medication prescribed? (ndclist.com)
Dosage2
  • Paradoxically, benztropine is given to people on extended dosage plans involving phenothiazines used for psychosis . (drugs-forum.com)
  • Benztropine mesylate may be used concomitantly with Carbidopa-Levodopa, or with levodopa, in which case periodic dosage adjustment may be required in order to maintain optimum response. (seniorhealthcarematters.com)
Side effects10
  • Side effects from benztropine are common. (medlineplus.gov)
  • Benztropine may cause other side effects. (medlineplus.gov)
  • Using benztropine together with dextromethorphan may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. (drugs.com)
  • Certain side effects of benztropine may be more likely in older adults. (wellspan.org)
  • Although many side effects of benztropine are minor, some side effects are more serious and require immediate medical care. (emedtv.com)
  • Some of the common side effects of benztropine can include constipation, nausea, and blurred vision. (emedtv.com)
  • This article covers many, but not all, of the possible side effects with benztropine. (emedtv.com)
  • Your healthcare provider can discuss a more complete list of benztropine side effects with you. (emedtv.com)
  • Some side effects with benztropine are potentially serious and should be reported immediately to your healthcare provider. (emedtv.com)
  • Other benztropine side effects not listed above may also occur in some patients. (verywellmind.com)
Drug4
  • benztropine is a topic covered in the Davis's Drug Guide . (drugguide.com)
  • Davis's Drug Guide - OLD - USE 2.0 , www.drugguide.com/ddo/view/Davis-Drug-Guide/51094/all/benztropine. (drugguide.com)
  • 2020. https://www.drugguide.com/ddo/view/Davis-Drug-Guide/51094/all/benztropine. (drugguide.com)
  • This targeted anti-inflammatory agent improves physical deficits in experimental autoimmune encephalomyelitis (EAE), an animal model of MS. Here, we sought to determine whether tuftsin is also effective in combination with benztropine, an FDA-approved drug that stimulates remyelination, in both EAE and in the cuprizone model of demyelination. (frontiersin.org)
Tardive2
  • Benztropine should never be used to treat tardive dyskinesia. (emedtv.com)
  • Not only is benztropine ineffective for this use, it can actually make tardive dyskinesia worse. (emedtv.com)
Dopamine2
  • In vitro activity: Benztropine inhibits MTSET-induced inhibition of [3H]WIN binding to Wild-type dopamine transporter with EC50 of 28 μM in concentration-dependent manner. (invivochem.com)
  • Benztropine (5 mg/kg and 25 mg/kg) shows dose-dependent elevations in extracellular dopamine in the striatum of the rat. (invivochem.com)
Analogs2
  • Among them, the benztropine (BZT) derivatives, N -butyl (JHW007), N -allyl (AHN2-005), and N -methyl (AHN1-055) analogs of 3 α -[bis(4′-fluorophenyl)methoxy]-tropane dose-dependently decreased cocaine self-administration without effects on food-maintained responding. (aspetjournals.org)
  • Recently, extensive behavioral research has been conducted on the benztropine (BZT) analogs with the goal of developing successful therapeutics for cocaine abuse. (aspetjournals.org)
Methanesulfonate1
  • Benztropine is designated chemically as 3a-( Diphenylmethoxy)-1 aH, 5aH- tropane methanesulfonate. (drugs-forum.com)
20161
  • Fresenius Kabi launched benztropine in September 2016. (ashp.org)
Healthcare provider2
  • What should I discuss with my healthcare provider before taking benztropine? (wellspan.org)
  • Benztropine: What Should I Tell My Healthcare Provider? (emedtv.com)
Anticholinergics1
  • Benztropine belongs to a class of medication called anticholinergics that work by blocking a certain natural substance (acetylcholine). (ndclist.com)
Dose3
  • Your doctor may start with a small dose and increase it slowly after seeing your response to benztropine. (medlineplus.gov)
  • The recommended adult dose of benztropine is usually 1 mg to 2 mg daily, although the dose can range from 0.5 mg to 6 mg daily depending on circumstances. (medbroadcast.com)
  • Benztropine will be titrated up from .125 mg qhs to a maximum dose of .750 mg qhs based on treatment response and side effect profile. (clinicaltrials.gov)
Medicine8
  • If you have an allergy to benztropine or any other part of this medicine. (drugs.com)
  • Tell all of your health care providers that you take this medicine (benztropine tablets). (drugs.com)
  • How is this medicine (Benztropine Tablets) best taken? (drugs.com)
  • Use this medicine (benztropine tablets) as ordered by your doctor. (drugs.com)
  • Sweating less, heat stroke, and deadly high body temperatures have happened with this medicine (benztropine tablets). (drugs.com)
  • You should not use this medicine if you have had an allergic reaction to benztropine. (limamemorial.org)
  • I have been steered on benztropine for at least a year and i have not noticed and nervousness due to this medicine. (rosesturn.com)
  • prescription of medicine decreases Benztropine exposure, but is not associated with opiate withdrawal in opioid dependent individuals. (captainherb.net)
Drowsiness2
  • remember that alcohol can add to the drowsiness caused by benztropine. (medlineplus.gov)
  • Benztropine can cause drowsiness, confusion, or other mental problems that may interfere with your ability to drive or operate heavy machinery. (emedtv.com)
Precautions2
  • There are several precautions and warnings with benztropine to be aware of before starting this medication. (emedtv.com)
  • Precautions and warnings with benztropine also apply to people who have certain allergies, who are under the age of three years old, or who have certain health conditions (such as glaucoma, a rapid heart rate, or an enlarged prostate). (emedtv.com)
Antiparkinsonian1
  • When benztropine mesylate is started, do not terminate therapy with other antiparkinsonian agents abruptly. (seniorhealthcarematters.com)
Tablets2
  • Hypersensitivity to any components of benztropine mesylate tablets. (nih.gov)
  • Benztropine mesylate tablets should be used when patients are able to take oral medication. (seniorhealthcarematters.com)
Patients1
  • What we need to find out is whether patients taking benztropine are less likely to get MS, whether patients with MS who go on benztropine have noticed any difference in their MS and whether this treatment is useful for anything else. (rxisk.org)
Pregnancy2
  • Using benztropine during pregnancy could harm the unborn baby. (wellspan.org)
  • Benztropine is usually considered a pregnancy Category C medication. (emedtv.com)
Breast milk2
  • It is not known whether benztropine passes into breast milk or if it could harm a nursing baby. (wellspan.org)
  • It is not known if benztropine passes through breast milk. (emedtv.com)
Nortriptyline1
  • This is a randomized, controlled trial evaluating pharmacological (nortriptyline vs. active placebo - benztropine) and psychological (cognitive-behavioral therapy vs. disease education) treatments for pain and disability due to temporomandibular joint disorder (TMD). (clinicaltrials.gov)
Relieve1
  • Study participants will be assigned to treatment with either a antidepressant acting on the serotonin system in the brain (fluoxetine), one acting on the noradrenaline system (desipramine, or to a control medication not expected to relieve pain (benztropine). (clinicaltrials.gov)
Search2
  • A search of the medical literature using PubMed, however, found no further recent published reports of Benztropine in the treatment of hyperhidrosis. (sweathelp.org)
  • For brands that may still be available, search under benztropine. (rxhealthmed.ca)
BENZTROPINE MESYLATE (injection) | Dosage and Administration | Healthgrades.com
BENZTROPINE MESYLATE (injection) | Dosage and Administration | Healthgrades.com (healthgrades.com)
Benztropine: Pediatric Medication | Memorial Sloan Kettering Cancer Center
Benztropine: Pediatric Medication | Memorial Sloan Kettering Cancer Center (mskcc.org)
Medication-Induced Dystonic Reactions Medication: Anticholinergic agents, Benzodiazepines
Medication-Induced Dystonic Reactions Medication: Anticholinergic agents, Benzodiazepines (emedicine.medscape.com)
Benztropine (Injection Route) Description and Brand Names - Mayo Clinic
Benztropine (Injection Route) Description and Brand Names - Mayo Clinic (mayoclinic.org)
Benztropine
Benztropine (webbook.nist.gov)
DailyMed - BENZTROPINE MESYLATE injection
DailyMed - BENZTROPINE MESYLATE injection (dailymed.nlm.nih.gov)
Cogentin (benztropine) Uses, Side Effects, Dosage & Interactions
Cogentin (benztropine) Uses, Side Effects, Dosage & Interactions (emedicinehealth.com)
Drug Shortage Detail: Benztropine Mesylate Injection
Drug Shortage Detail: Benztropine Mesylate Injection (ashp.org)
Benztropine - WellSpan Health Library
Benztropine - WellSpan Health Library (wellspan.org)
Benztropine: MedlinePlus Drug Information
Benztropine: MedlinePlus Drug Information (medlineplus.gov)
Connecting Neuronal Cell Protective Pathways and Drug Combinations in a Huntington's Disease Model through the Application of...
Connecting Neuronal Cell Protective Pathways and Drug Combinations in a Huntington's Disease Model through the Application of... (nature.com)
Https://www.medicalnewstoday.com/articles/323514.php
Https://www.medicalnewstoday.com/articles/323514.php (medicalnewstoday.com)
Prescribers guide stahls essential psychopharmacology 7th edition | Mental health, psychiatry and clinical psychology |...
Prescribers guide stahls essential psychopharmacology 7th edition | Mental health, psychiatry and clinical psychology |... (cambridge.org)
Drugs that may cause erection problems: MedlinePlus Medical Encyclopedia
Drugs that may cause erection problems: MedlinePlus Medical Encyclopedia (medlineplus.gov)
August 1993 - Volume 16 - Issue 4 : Clinical Neuropharmacology
August 1993 - Volume 16 - Issue 4 : Clinical Neuropharmacology (journals.lww.com)
Clozaril Advanced Patient Information - Drugs.com
Clozaril Advanced Patient Information - Drugs.com (drugs.com)
Laxative (Oral Route) Before Using - Mayo Clinic
Laxative (Oral Route) Before Using - Mayo Clinic (mayoclinic.org)
Amantadine | Side Effects, Dosage, Uses, and More
Amantadine | Side Effects, Dosage, Uses, and More (healthline.com)
Novo-Peridol Advanced Patient Information - Drugs.com
Novo-Peridol Advanced Patient Information - Drugs.com (drugs.com)
Effect of Antidepressants on Back Pain - Full Text View - ClinicalTrials.gov
Effect of Antidepressants on Back Pain - Full Text View - ClinicalTrials.gov (clinicaltrials.gov)
Fatal Foodborne Clostridium perfringens Illness at a State Psychiatric Hospital - Louisiana, 2010
Fatal Foodborne Clostridium perfringens Illness at a State Psychiatric Hospital - Louisiana, 2010 (cdc.gov)
Chlorpheniramine/methscopolamine/phenylephrine Disease Interactions - Drugs.com Interactions Checker
Chlorpheniramine/methscopolamine/phenylephrine Disease Interactions - Drugs.com Interactions Checker (drugs.com)
Drooling: Check Your Symptoms and Signs
Drooling: Check Your Symptoms and Signs (rxlist.com)
Benztropine - International Hyperhidrosis Society | Official Site
Benztropine - International Hyperhidrosis Society | Official Site (sweathelp.org)
Budesonide Assay Standard- CAS Number 51333-22-3
Budesonide Assay Standard- CAS Number 51333-22-3 (lgcstandards.com)
Anticholinergics: List, Side Effects, Uses, Warnings, and More
Anticholinergics: List, Side Effects, Uses, Warnings, and More (healthline.com)
Morphine (AVINza, Duramorph) | Davis's Drug Guide
Morphine (AVINza, Duramorph) | Davis's Drug Guide (unboundmedicine.com)
Cerebral Palsy | HealthLink BC
Cerebral Palsy | HealthLink BC (healthlinkbc.ca)