Benzopyrroles with the nitrogen at the number two carbon, in contrast to INDOLES which have the nitrogen adjacent to the six-membered ring.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Major structural proteins of triacylglycerol-rich LIPOPROTEINS. There are two forms, apolipoprotein B-100 and apolipoprotein B-48, both derived from a single gene. ApoB-100 expressed in the liver is found in low-density lipoproteins (LIPOPROTEINS, LDL; LIPOPROTEINS, VLDL). ApoB-48 expressed in the intestine is found in CHYLOMICRONS. They are important in the biosynthesis, transport, and metabolism of triacylglycerol-rich lipoproteins. Plasma Apo-B levels are high in atherosclerotic patients but non-detectable in ABETALIPOPROTEINEMIA.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Any of various enzymatically catalyzed post-translational modifications of PEPTIDES or PROTEINS in the cell of origin. These modifications include carboxylation; HYDROXYLATION; ACETYLATION; PHOSPHORYLATION; METHYLATION; GLYCOSYLATION; ubiquitination; oxidation; proteolysis; and crosslinking and result in changes in molecular weight and electrophoretic motility.
The most abundant protein component of HIGH DENSITY LIPOPROTEINS or HDL. This protein serves as an acceptor for CHOLESTEROL released from cells thus promoting efflux of cholesterol to HDL then to the LIVER for excretion from the body (reverse cholesterol transport). It also acts as a cofactor for LECITHIN CHOLESTEROL ACYLTRANSFERASE that forms CHOLESTEROL ESTERS on the HDL particles. Mutations of this gene APOA1 cause HDL deficiency, such as in FAMILIAL ALPHA LIPOPROTEIN DEFICIENCY DISEASE and in some patients with TANGIER DISEASE.
The rate dynamics in chemical or physical systems.

Enhancement of osteogenesis in vitro and in vivo by a novel osteoblast differentiation promoting compound, TAK-778. (1/16)

TAK-778 [(2R,4S)-(-)-N-(4-diethoxyphosphorylmethylphenyl)-1,2,4, 5-tetrahydro-4-methyl-7, 8-methylenedioxy-5-oxo-3-benzothiepin-2-carboxyamide; mw 505.53], a novel osteoblast differentiation promoting compound, was characterized in vitro and in vivo models. TAK-778 at doses of 10(-6) M and higher promoted potently bone-like nodule formation in the presence of dexamethasone in rat bone marrow stromal cell culture. This was accompanied by increases in cellular alkaline phosphatase activity, soluble collagen release, and osteocalcin secretion. Under the culture conditions, TAK-778 also stimulated the secretion of transforming growth factor-beta and insulin-like growth factor-I, indicating that TAK-778 may exert regulatory effects on osteoblast differentiation via autocrine/paracrine mechanisms. Furthermore, the in vivo osteogenic potential of TAK-778 was studied in bony defect and osteotomy animal models, using sustained release microcapsules consisted of a biodegradable polymer, poly (dl-lactic/glycolic) acid (PLGA). Single local injection of TAK-778/PLGA-microcapsules (PLGA-MC) (0.2-5 mg/site) to rat skull defects resulted in a dose-dependent increase in new bone area within the defects after 4 weeks. When the pellet containing TAK-778/PLGA-MC (4 mg/pellet) was packed into place to fill the tibial segmental defect in rabbit, this pellet induced osseous union within 2 months, whereas the placebo pellet did not. In addition, single local application of TAK-778/PLGA-MC (10 mg/site) to rabbit tibial osteotomy site enhanced callus formation accompanied by an increase in breaking force after 30 days. These results reveal for the first time that a nonendogenous chemical compound promotes potently osteogenesis in vitro and enhances new bone formation during skeletal regeneration and bone repair in vivo and should be useful for the stimulation of fracture healing.  (+info)

Effects of histamine H1 antagonist dithiaden on acetic acid-induced colitis in rats. (2/16)

To assess the possible involvement of mast cells and/or their mediators in inflammatory bowel diseases, the effect of the histamine H1 antagonist Dithiaden was studied on a model of acetic acid-induced colitis in rats. Dithiaden pretreatment by intracolonic administration was found to reduce the extent of acute inflammatory colonic injury. This was manifested by a decrease in the score of gross mucosal injury, by lowered colonic wet weight and by diminished myeloperoxidase activity reflecting reduced leukocyte infiltration. Vascular permeability and gamma-glutamyl transpeptidase activity, elevated by acetic acid exposure, were decreased after Dithiaden pretreatment. The results indicate that locally administered Dithiaden may protect the colonic mucosa against an acute inflammatory attack by interfering with the action of the major mast cell mediator histamine.  (+info)

Synthesis of 1-benzothiepine and 1-benzazepine derivatives as orally active CCR5 antagonists. (3/16)

Quaternary ammonium benzocycloheptene compound 1 has previously been reported as a clinical candidate for an injectable CCR5 antagonist. In order to develop an orally active CCR5 antagonist, derivatives of tertiary amine benzocycloheptene 2, the chemical precursor to 1, were investigated. The benzocycloheptene ring was converted to benzothiepine and benzazepine rings and it was found that these changes could enhance the potency of tertiary amine derivatives. In particular, the 1-benzothiepine-1,1-dioxide 11b and the N-methyl-1-benzazepine 18 showed increased activity and good preliminary pharmacokinetic properties. The synthesis of 1-benzothiepine and 1-benzazepine derivatives and their activity are described.  (+info)

KW-7158 [(2S)-(+)-3,3,3-trifluoro-2-hydroxy-2-methyl-N-(5,5,10-trioxo-4,10-dihydrothieno[ 3,2-c][1]benzothiepin-9-yl)propanamide] enhances A-type K+ currents in neurons of the dorsal root ganglion of the adult rat. (4/16)

Recent studies revealed that a new compound, KW-7158 [(2S)-(+)-3,3,3-trifluoro-2-hydroxy-2-methyl-N-(5,5,10-trioxo-4,10-dihydrothieno[ 3,2-c][1]benzothiepin-9-yl)propanamide], can depress the excitability of afferent pathways from the urinary bladder and reduce bladder overactivity induced by chemical irritation of the urinary tract with xylene, an agent that sensitizes capsaicin-sensitive, C-fiber afferent nerves. In the present experiments, we examined the mechanisms that might underlie the depressant effect of KW-7158 on primary afferent neurons by studying the actions of the compound on ion channels and firing in dissociated dorsal root ganglion (DRG) cells from adult rats using whole cell patch-clamp techniques. KW-7158 increased transient, A-type K+ currents at concentrations ranging from 50 nM to 1 microM (20-50% increases). Similar effects were seen in fast blue identified bladder afferent neurons. Low concentrations of KW-7158 shortened the action potential duration, produced a 5- to 10-mV hyperpolarization, and inhibited repetitive firing induced by either 4-AP (50 microM) or substance P (0.5 microM) in phasic firing DRG neurons. Above 1 microM, KW-7158 elicited a smaller enhancement of A-type K+currents and in high concentrations inhibited the currents. Tetraethylammonium (5-60 mM) and verapamil (50 microM), which block noninactivating K+ currents, did not prevent the facilitatory effects of KW-7158. High concentrations of 4-AP (5 mM) inhibited A-type K+ currents and prevented the facilitatory effect of KW-7158 on the remaining currents. These data suggest that KW-7158 enhances A-type K+ currents in DRG neurons. Because A-type K+ channels regulate afferent neuron excitability and firing properties, KW-7158 is a promising new compound for treatment of hyper-reflexic bladder conditions.  (+info)

Orally active CCR5 antagonists as anti-HIV-1 agents: synthesis and biological activity of 1-benzothiepine 1,1-dioxide and 1-benzazepine derivatives containing a tertiary amine moiety. (5/16)

The search for orally active CCR5 antagonists was performed by chemical modification of the 1-benzothiepine 1,1-dioxide 3 and 1-benzazepine 4 lead compounds containing a tertiary amine moiety. Replacement of methyl group with a 2-(C(2-4) alkoxy)ethoxy group at the 4-position on the 7-phenyl group of the 1-benzothiepine ring resulted in both enhanced activity and significant improvement in the pharmacokinetic properties upon oral administration in rats. Introduction of C(2-4) alkyl, phenyl or (hetero)arylmethyl groups as the 1-substituent on the 1-benzazepine ring together with the 2-(butoxy)ethoxy group led to further increase of activity. Among the 1-benzazepine derivatives, the isobutyl (6i), benzyl (6o) or 1-methylpyrazol-4-ylmethyl (6s) compounds were found to exhibit highly potent inhibitory effects, equivalent to the injectable CCR5 antagonist 1, in the HIV-1 envelope-mediated membrane fusion assay. In particular, compound 6s showed the most potent CCR5 antagonistic activity (IC(50)=2.7 nM) and inhibitory effect (IC(50)=1.2 nM) on membrane fusion, together with good pharmacokinetic properties in rats. The synthesis of 1-benzothiepine 1,1-dioxide and 1-benzazepine derivatives and their biological activity are described.  (+info)

Protein kinase Cbeta is a critical regulator of dopamine transporter trafficking and regulates the behavioral response to amphetamine in mice. (6/16)

 (+info)

The novel neuropeptide Y Y5 receptor antagonist Lu AA33810 [N-[[trans-4-[(4,5-dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]me thyl]-methanesulfonamide] exerts anxiolytic- and antidepressant-like effects in rat models of stress sensitivity. (7/16)

 (+info)

Persistent (current) in the face of adversity ... a new class of cardiac anti-ischaemic compounds on the horizon? (8/16)

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The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
A novel series of thiepine derivatives were synthesized and evaluated as potential antimicrobials. All the synthesized compounds were evaluated for their antimicrobial activities in vitro against the fungi Candida albicans (ATCC 10231), C.parapsilosis (clinical isolate), Gram-negative bacterium Pseudomonas aeruginosa (ATCC 44752), and Gram-positive bacterium Staphylococcus aureus (ATCC 25923). Synthesized compounds showed higher antifungal activity than antibacterial activity, indicating that they could be used as selective antimicrobials. Selected thiepines efficiently inhibited Candida hyphae formation, a trait necessary for their pathogenicity. Thiepine 8-phenyl[1]benzothiepino[3,2-c]pyridine (16) efficiently killed Candida albicans at 15.6g/mL and showed no embryotoxicity at 75g/mL. Derivative 8-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl][1]benzothiepino[3,2-c]pyridine (23) caused significant hemolysis and in vitro DNA interaction. The position of the phenyl ring was essential for the... ...
(1-amino-2-methylpropyl)phosphonic acid Catalog Id: MM18108242 IUPAC:(1-Amino-2-methylpropyl)phosphonicacid CAS Number: 18108-24-2 Formula: C4H12NO3P SMILES: CC(C)C(N)P(O)(O)=O Molecular Weight: 153.118 Preferred IUPAC Name: (1-amino-2-methylpropyl)phosphonic acid InChIKey: InChIKey=DGSLPJDIFKVSIB-UHFFFAOYNA-N
1-Methyl-4-[3-[(2-methyltetrazol-5-yl)methyl]-5,6-dihydrobenzo[b][1]benzothiepin-5-yl]piperazine | C22H26N6S | CID 49781890 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Read about the chemical and physical properties of (2R,3R)-2-(1-(2-((S)-1-amino-2-methylpropyl)-4-methylphenyl)piperazine-4-carbonyl)-3-(4-chlorophenyl)-N,N-dimethylpyrrolidine-1-carboxamide. Get (2R,3R)-2-(1-(2-((S)-1-amino-2-methylpropyl)-4-methylphenyl)piperazine-4-carbonyl)-3-(4-chlorophenyl)-N,N-dimethylpyrrolidine-1-carboxamide molecular formula, CAS number, boiling point, melting point, applications, synonyms and more here.
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Representative natural products containing benzoxa[3.2.1]octane skeleton and approaches to it.(a) Selected bioactive natural products having benzoxa[3.2.1]octan
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2-(2-Methylpropyl)-N-(thietan-3-yl)pyrazol-3-amine | C10H17N3S | CID 130891501 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Buy high quality N-[(1S)-1-(Aminocarbonyl)-2-methylpropyl]-1-[(3-fluorophenyl)methyl]-1H-indazole-3-carboxamide 1185282-19-2 from toronto research chemicals Inc.
51734-37-3 - KGGIFQOTGCPQAV-UHFFFAOYSA-N - 2-Propanol, 1-(bis(2-methylpropyl)amino)-3-(diethylamino)-, benzoate (ester), dihydrochloride - Similar structures search, synonyms, formulas, resource links, and other chemical information.
Comprehensive supplier list for Butanenitrile, 2-[(1-cyano-1-methylethyl)azo]-2-methyl-,Butanenitrile, 2-[(1-cyano-1-methylpropyl)azo]-2,3-dimethyl-
110-19-0 Isobutyl acetate testing. Laboratory testing for CAS number 110-19-0. Acetic acid, 2-methylpropyl ester;Acetic acid, isobutyl ester;«beta»-Methylpropyl ethanoate;2-Methylpropyl acetate;2-Methyl-1-propyl acetate;Isobutyl acetate fcc;Acetate disobutyle;Isobutyl ethanoate;2-Methylpropyl ethanoate;Isobutylester kyseliny octove;UN 1213;2-Methyl-1-propanol, acetate;i-Butyl acetate.
3-Methyl-6-phenyl-2-thioxo-2,3-dihydrothieno[3,2-d]pyrimidin- 4(1H)-one (2), on treatment with phosphorous oxychoride, affored 4-chloro-3-methyl-6-phenyl -thieno[3,2-d]pyrimidine- 2(3H)-thione (3). A series of novel 6-phenyl-thieno[3,2-d]pyrimidine derivatives 4-9 bearing different functional groups were synthesized via treatment of compound 3 with different reagents. On the other hand, compound 2 was used to synthesize ethyl-[(3-methyl-6-phenyl-2-thioxo-2,3-dihydrothieno[ 3,2-d]pyrimidin-4-yl)-oxy]acetate (10), 2-hydrazinyl- -3-methyl-6-phenyl-thieno[3,2-d]pyrimidin-4(3H)-one (11), 3-methyl-2-(methyl-sulfanyl)-6-phenyl-thieno[3,2-d]pyrimidin- 4(3H)-one (12) and N-(phenyl)/4-chlorophenyl or methoxy- phenyl)-2-[(3-methyl-4-oxo-6-phenyl-3,4-dihydrothieno[ 3,2-d]pyrimidin-2-yl)-sulfanyl]-acetamide (13a-c ...
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Find quality suppliers and manufacturers of 220119-17-5(Avermectin A1a,25-cyclohexyl-4-O-de(2,6-dideoxy-3-O-methyl-a-L-arabino-hexopyranosyl)-5-demethoxy-25-de(1-methylpropyl)-22,23-dihydro-5-(hydroxyimino)-,(5Z)-) for price inquiry. where to buy 220119-17-5(Avermectin A1a,25-cyclohexyl-4-O-de(2,6-dideoxy-3-O-methyl-a-L-arabino-hexopyranosyl)-5-demethoxy-25-de(1-methylpropyl)-22,23-dihydro-5-(hydroxyimino)-,(5Z)-).Also offer free database of 220119-17-5(Avermectin A1a,25-cyclohexyl-4-O-de(2,6-dideoxy-3-O-methyl-a-L-arabino-hexopyranosyl)-5-demethoxy-25-de(1-methylpropyl)-22,23-dihydro-5-(hydroxyimino)-,(5Z)-) including MSDS sheet(poisoning, toxicity, hazards and safety),chemical properties,Formula, density and structure, solution etc.
Comprehensive supplier list for 1(2H)-PYRIMIDINEACETIC ACID 3-BUTYLTETRAHYDRO-2,4,6-TRIOXO-,1(2H)-PYRIMIDINEACETIC ACID 4-AMINO-5-[[[3,4-DIHYDRO-2,5,7,8-TETRAMETHYL-6-(PHENYLMETHOXY)-2H-1-BENZOPYRAN-2-YL]CARBONYL]AMINO]-3,6-DIHYDRO-2,6-DIOXO-
Buy this product, a biochemical for proteomics research, from Santa Cruz Biotechnology. Molecular Formula: C24H22ClN3O3S2, Molecular Weight: 500.03
4-methyl-N-(4-methylphenyl)-N-phenylaniline 20440-95-3 NMR spectrum, 4-methyl-N-(4-methylphenyl)-N-phenylaniline H-NMR spectral analysis, 4-methyl-N-(4-methylphenyl)-N-phenylaniline C-NMR spectral analysis ect.
4H-Indolo[4,3-fg][3,1]benzoxazine,6,6a,7,8,10,- 10a-hexahydro-7,8-dimethyl-10-(1-methylethenyl)-,(6aR,8R,10R,10aR)- 1,3-bis(2-methylprop-2-enyl)-2-prop-2-enoxy-benzene Benzeneacetic acid, alpha-methyl-4-(4-oxo-2-(propylthio)-3(4H)-quinazolinyl)-, methyl ester 4-methyl-6-(2,2,3,3,4,4,5,5-octafluoropentoxy)pyrimidin-2-amine 2-Propanol, 1-((1-methylpropyl)thio)-3-(6,7,10,11-tetramethoxyemetan-2-yl)-, 2HCl Benzyl (3S-(2(R*),3alpha,8abeta))-1-(3-benzylhexahydro-1,4-dioxopyrrolo(1,2-a)pyrazin-2(1H)-yl)-1-oxopropane-2-carbamate 4-(4,5-dichloro-6-oxo-pyridazin-1-yl)benzenesulfonamide 3-(benzyl-methyl-amino)-1-naphthalen-2-yl-propan-1-one 4-amino-4-methyl-pentanoic acid 6-amino-5H-purine-2-sulfonamide
Amines, C12-14-tert-alkyl, mixed sec-Bu and iso-Bu phosphates (CAS 96690-34-5) is an UVCB substance comprising negatively charged organophosphate and positively charged amine groups. The substance is characterized by a water solubility of 1322 mg/L at 25 °C and pH 3.57 and a low vapour pressure of ≤ 54 Pa at 20 °C. The Log Kow values are summarized within the table below (see Table 1) and were within a range of 0.686 and 5.6347. The Log Koc was calculated based on representative components of 2-methylpropyl dihydrogen phosphate, bis(2-methylpropyl) hydrogen phosphate and 2-methyltridecan-2-amine with a Log Koc of 1.55, 1.78 and 4.75, respectively. Hydrolysis is not considered to be a relevant degradation pathway of the substance. The amine components of the test substance are generally hydrolytically stable in the environment where as the organophosphate groups hydrolyse slowly in contact with water. Furthermore the amine groups have a high potential for adsorption to soil and sediment. ...
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice ...
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice ...
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
Diazotization of 4-fluoroanthranilic acid (V) and the following reaction with sodium disulfide gave the dithio diacid VII which was reduced with lithium aluminium hydride to 4-fluoro-2-mercaprobenzyl alcohol (XI). Its reaction with 2-chloro-5-iodothiophene afforded the alcohol XIII which was transformed via the chloride XIV and the nitrile XV to [2-(5-chloro-2-thienylthio)-4-fluorophenyl]acetic acid (XVI). Cyclization with phosphorus pentoxide in toluene resulted in 2-chloro-8-fluorothieno[2,3-b]-1-benzothiepin-4(5H)-one (XVIII) which was converted via the alcohol XIX to the chloro derivative XX. The substitution reaction with 1-methylpiperazine led to the title compound IV which is a long-acting and very potent tranquillizer but did not reveal, in the animal tests performed, the properties of a neuroleptic agent.. ...
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Structure, properties, spectra, suppliers and links for: N-(1-Cycloheptyl-3-piperidinyl)-3-(5-methyl-1H-pyrazol-1-yl)propanamide.
You are viewing an interactive 3D depiction of the molecule n-{[4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)phenyl]sulfonyl}propanamide (C19H18N2O4S) from the PQR.
Structure, properties, spectra, suppliers and links for: (2S)-2-(8-Iodo-1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-9H-purin-9-yl)propanamide.
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Products list 7S,9S 7 2R,4S,5R,6S 4 amino 5 hydroxy 6 methyloxan 2 yl oxy 6,9,11 trihydroxy 9 2 hydroxyacetyl 4 methoxy 8,10 dihydro 7H tetracene 5,12 dione 3 O methyl 5 O 2 methylpropyl 2,6 dimethyl 4 2 nitrophenyl 1,4 dihydropyridine 3,5 dicarboxylate
BenzaMiDe, N-[2-(3,4-Difluoro[1,1-biphenyl]-3-yl)-2-Methylpropyl]-3-[5-(trifluoroMethyl)-1,2,4-oxaDiazol-3-yl]-;1429029-53-7;ABP006773.Active Biopharma Corp
N-(1-((4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)methyl)-2-methylpropyl)-7-methoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxamide:
N(1),N(3)-diethyl-5-(5-(N(1),N(3)-diethyl-2,4,6-trioxo-1,2,3,4,5,6-hexahydropyrimidin-5-ylidene)-penta-13-diene-1-yl)barbituric acid: structure given in first source
0033]Starting materials of formula (III) of the present invention are available commercially or from known methods in the art as disclosed in the following list: [0034]2,5-dimethyl-3(2H)-furanone, from Ryan Scientific Product List. [0035]4-(1,1-dimethylethyl)-2,5-dimethyl-3(2H)-furanone, from JP10036259. [0036](S)-2,5-dimethyl-3(2H)-furanone and (R)-2,5-dimethyl-(2H)-furanone, from Eghbaldar et al., Parfums, Cosmetiques, Aromes (1992), 104, 71-8. [0037](R)-5-hexyl-2-methyl-3(2H)-furanone and (S)-5-hexyl-2-methyl-3(2H)-furanone, from Mosandl et al. Journal of High Resolution Chromatography (1990), 13(9), 660-2. [0038]2-methyl-4-(2-methylpropyl)-3(2H)-furanone and 2-methyl-4-pentyl-3(2H)-furanone, from Baraldi et al. Tetrahedron (1987), 43(1), 235-42. [0039]2-methyl-5-(2-methylpropyl)-3(2H)-furanone, 2-methyl-5-phenyl-3(2H)-furanone, and 2-methyl-5-pentyl-3(2H)-furanone, from Baraldi et al. Tetrahedron Letters (1984), 25(38), 4313-16. [0040]5-hexyl-2-methyl-3(2H)-furanone, from Winkler et al. ...
IN CONNECTION WITH A STUDY OF POLYMERS CONTAINING HIGH-ENERGY GROUPS, POLY( -nitro-2-methylpropyl methacrylate) was prepared in both the isotactic (m.p. above 300 C.) and the atactic (m.p. 280 C.) forms. Isotactic poly(2-nitro-2methylpropyl methacrylate) was prepared by adding the monomer to a relatively large amount of toluene containing phenylmagnesium bromide as a catalyst. Atactic poly(2-ni ro-2-met ylpropyl m h cryl ) AS PREP RED BY A CONVENTIO AL FREE RADICAL-TYP POLYMERIZATION USING AZOBISISOBUTYRONITRILE. Similarly, isotactic poly(methyl methacrylate) (m.p. 140-160 C.) was prepared and compared with a commercially available sample of atactic poly(methyl methacrylate) (m.p. 120125 C.). Contrary to previous observations that the isotactic form of a polymer had higher mechanical strength than the atactic form, a actic poly(methyl methacrylate) had a higher tensile strength than the isotactic modification. (Author)*ACRYLIC RESINS
Buy highly pure Ibuprofen - Impurity Q, CAS No : 36039-35-7, Mol.Formula : C12H18O, Mol.Weight : 178.27, from Pharmaffiliates. Login as registered user for prices, availability and discounts.
The background program outlined in the CCR Rule does not require the monitoring of changes in the overall environmental conditions as indicated by the criteria listed above. Without the proper establishment of these background environmental conditions within the groundwater system (flowing under the CCR unit), it will be difficult to discern whether an increase in a COC concentration is related to changes in overall groundwater conditions or whether the increase is due to a release from the CCR unit itself. Therefore, GHD recommends that any baseline or background monitoring of groundwater near the CCR units include the environmental indicators listed above (i.e., DO, Redox, microbes, and select metals). Not only are these indicators important in establishing an accurate detection monitoring system, but these same parameters are critical to the post-closure or post-corrective action phase at any CCR unit.. As is expected, many inactive and active CCR units will be closed because they do not meet ...
1,2,4-Trifluoro-5-nitrobenzene 2105-61-5 route of synthesis, 1,2,4-Trifluoro-5-nitrobenzene chemical synthesis methods, 1,2,4-Trifluoro-5-nitrobenzene synthetic routes ect.
You are viewing an interactive 3D depiction of the molecule n-{6-[(2,5-dioxo-1-pyrrolidinyl)oxy]-6-oxohexyl}-3-(2-pyridinyldisulfanyl)propanamide (C18H23N3O5S2) from the PQR.
88133-19-1 - KIGWLQJAJQIKNY-PLCQNAAUSA-N - alpha-Cyano-9,10-didehydro-6-methyl-ergoline-8-propanamide, (8beta)- - Similar structures search, synonyms, formulas, resource links, and other chemical information.
Polívka, Zdeněk; Rajšner, Miroslav; Metyš, Jan; Holubek, Jiří; Svátek, Emil; Ryska, Miroslav; Protiva, Miroslav (1983). Antiaminic agents derived from thieno[2,3-c]-2-benzothiepin: 4-(1-Methyl-4-piperidylidene)-4,9-dihydrothieno[2,3-c]-2-benzothiepin and some related compounds. Collection of Czechoslovak Chemical Communications. 48 (2): 623-641. doi:10.1135/cccc19830623 ...
US EPA PC Code ); 012303 (US EPA PC Code Text ); 5-Bromo-3-sec-butyl-6-methyluracil, sodium salt; 5-Bromo-6-methyl-3-(1-methylpropyl)-2,4(1H,3H)-pyrimidinedione, sodium salt; 69484-12-4 (CAS number); 69484124; 69484124 (CAS number without hyphens); 842 (CA DPR Chem Code) ); Bromacil, sodium salt; BROMACIL, SODIUM SALT (CA DPR Chem Code Text ); Bromacilsodiumsalt; Uracil, 5-bromo-3-sec-butyl-6-methyl-, sodium ...
SIDDHARTH INTERCHEM PVT. LTD. - Exporter, Manufacturer & Supplier of Itraconazole Intermediate 1-(4-Methoxyphenyl)-4-(4 -nitrophenyl) piperazine (IT - 1),2,4-Dihydro-4-[4-[4-(4-hydroxyphenyl]-1-piperazinyl]-phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one (IT - 7),1-(4-Methoxyphenyl) piperazine,Cis Bromo Benzoate,Cis Mesylate, India
The expression of P-glycoprotein (P-gp) in tumor cells causes a multidrug resistance (MDR) phenotype. P-gp has been shown to mediate the transport of structurally dissimilar drugs across the cell membrane in an energy-dependent manner. In this report, we show that BIBW22 BS, a phenylpteridine analog, reverses the MDR phenotype of CEM human lymphoma cells in a dose-dependent fashion. Using a photoactive analog of BIBW22 BS {[3H]azido-4-[N-(2-hydroxy-2-methylpropyl)-ethanolamino]-2, 7-bis(cis-2,6-dimethyl-morpholino)-6-phenylpteridine}, we show the photoaffinity labeling of a 170-kDa protein in drug-resistant cells immunoprecipitated with P-gp-specific monoclonal antibodies. The photolabeling of P-gp by [3H]azido-BIBW22 BS was specific and saturable. Furthermore, BIBW22 BS, vinblastine, and verapamil, but not colchicine, inhibited the photolabeling of P-gp by [3H]azido-BIBW22 BS. Drug binding studies showed that membranes from MDR cells bound more BIBW22 BS than parental drug-sensitive cells, and ...
Picaridin Icaridin 119515-38-7 97% In stock suppliers TCCS9 - Tocopharm Products Made In China, China Manufacturer. Icaridin Product Name: Icaridin Cas No: 119515-38-7 ; 107133-36-8 Synonyms: KBR 3023;Picaridin;1-(1-methyl-propoxycarbonyl)-2-(2-hydroxyethyl)-piperidine;1-(1-methylpropoxycarbonyl)-2-(2-hydroxyethyl)piperidine;1-methylpropyl2-(2-hydroxyethyl)-1-piperidinecarboxylate
The present invention relates to novel carbamate intermediate of formula (II), process for its preparation and process for its conversion into 3-[(1R,2R)-3-(dimethylamino)-1-ethyl-2-methylpropyl]phen
sec-Butanol, sec-Butanol Product Name: sec-Butanol Synonyms: (R,S)-Butan-2-ol;(RS)-2-butanol;1-Methyl propanol;1-methylpropanol;1-Methylpropyl alcohol;1-methylpropylalcohol;2-butanol,DL-;Alcool butylique sec, Auto Classifieds.
This page contains information on the chemical Pyridinium, 1-(6-hydroxy-4-oxo-7,7,7-trifluoro-6-(trifluoromethyl)heptyl)-, chloride including: 2 synonyms/identifiers.
methyl (E,4E)-5,5,5-trifluoro-4-(4-methylphenyl)iminopent-2-enoate - C13H12F3NO2, synthesis, structure, density, melting point, boiling point
Product Number: C5716 CAS number: 755038-65-4 Synonyms: N-[trans-4-[4-(cyclopropylmethyl)-1-piperazinyl]cyclohexyl]-4-[[(7R)-7-ethyl-5,6,7,8-tetrahydro-5-methyl-8-(1-methylethyl)-6-oxo-2-pteridinyl]amino]-3-methoxy-benzamide. ...
[3-(aminomethyl)phenyl]methanesulfonamide hydrochloride; CAS Number: 1240528-29-3; find Enamine-ENA296274931 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich
New series of 6-(arylthio)uracils, 6-(4-substituted-1-piperazinyl)uracils, 2,4,5-trioxo-1H,3H-benzothiopyrano[2,3-d]pyrimidine and 5-aryl-2,4-dioxo-1H,3H-pyrimido[5,4-f]benzo[1,4]thiazepines have been prepared and screened for their in vitro activity against herpes simplex-1 virus (HSV-1) and human immunodeficiency virus-1 (HIV-1). The in vitro cytotoxic activity was also evaluated. The results of biological testing revealed that compound 5b showed marginal activity against HSV-1, while compounds 5b and 5f exhibited marginal activity against HIV-1. The rest of the tested compounds were found devoid of antiviral activity against both HSV-1 and HIV-1 ...
अलीबाबा 3 Dihydro 1h Inden 2 एमाइन दुनिया की अग्रणी निर्यात उत्पादों बाजार है, आपको उच्च गुणवत्ता पूर्ण 3 Dihydro 1h Inden 2 एमाइन की आपूर्ति जानकारी का चयन देख सकते हैं, आप पा सकते हैं इसके अलावा थोक ऑनलाइन 3 Dihydro 1h Inden 2 एमाइन बातचीत, नवीनतम 3 Dihydro 1h Inden 2 एमाइन मूल्य उद्धरण और विश्वास के साथ खरीद।
As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
Trimetazidine is an anti-ischaemic agent with direct cardioprotective effects. It has been developed by the French company Servier for the prophylactic
Compare the utility of different models and approaches 2- Describe and explain the rationale behind the current pharmacological treatment of pulmonary arterial hypertension, Also, based on what is known about the pathophysiology of this condition, propose two additional mechanisms, not currently exploited, which might be targeted in order to treat it.. Type of service-Academic paper ...
Benzothiepins at the US National Library of Medicine Medical Subject Headings (MeSH) v t e. ...
BENZOTHIEPINS (75-85); RN given refers to parent cpd without isomeric designation ... minor descriptor (75-85); on-line & Index Medicus search DIBENZOTHIEPINS (69-74) & BENZOTHIEPINS (75-85); RN given refers to ...
Benzothiepins at the US National Library of Medicine Medical Subject Headings (MeSH) v t e. ...
4-Phenyl-2,3,4,5-tetrahydro-1-benzothiepins and some related compounds. 1972, Vol. 37, Issue 11, pp. 3808-3816 [Abstract] ...
4-Phenyl-2,3,4,5-tetrahydro-1-benzothiepins and some related compounds. 1972, Vol. 37, Issue 11, pp. 3808-3816 [Abstract] ...
Benzothiepins. Sub Class. Dibenzothiepins. Direct Parent. Dibenzothiepins. Alternative Parents. Alkylarylthioethers / ...
Benzothiepins (0) * beta-Lactams (0) * Cyclic S-Oxides (0) * Isothiocyanates (0) * Organothiophosphorus Compounds (0) ...
Benzothiepins (0) * beta-Lactams (0) * Cyclic S-Oxides (0) * Isothiocyanates (0) * Organothiophosphorus Compounds (0) ...
Bohula EA, Scirica BM, Inzucchi SE, McGuire DK, Keech AC, Smith SR, Kanevsky E, Murphy SA, Leiter LA, Dwyer JP, Corbalan R, Hamm C, Kaplan L, Nicolau JC, Ophuis TO, Ray KK, Ruda M, Spinar J, Patel T, Miao W, Perdomo C, Francis B, Dhadda S, Bonaca MP, Ruff CT, Sabatine MS, Wiviott SD. Effect of lorcaserin on prevention and remission of type 2 diabetes in overweight and obese patients (CAMELLIA-TIMI 61): a randomised, placebo-controlled trial. Lancet. 2018 11 24; 392(10161):2269-2279 ...
Biddlestone-Thorpe L, Sajjad M, Rosenberg E, Beckta JM, Valerie NC, Tokarz M, Adams BR, Wagner AF, Khalil A, Gilfor D, Golding SE, Deb S, Temesi DG, Lau A, OConnor MJ, Choe KS, Parada LF, Lim SK, Mukhopadhyay ND, Valerie K. ATM kinase inhibition preferentially sensitizes p53-mutant glioma to ionizing radiation. Clin Cancer Res. 2013 Jun 15; 19(12):3189-200 ...
Staszewski S, Morales-Ramirez J, Tashima KT, Rachlis A, Skiest D, Stanford J, Stryker R, Johnson P, Labriola DF, Farina D, Manion DJ, Ruiz NM. Efavirenz plus zidovudine and lamivudine, efavirenz plus indinavir, and indinavir plus zidovudine and lamivudine in the treatment of HIV-1 infection in adults. Study 006 Team. N Engl J Med. 1999 Dec 16; 341(25):1865-73 ...
Poole DP, Littler RA, Smith BL, McLeay LM. Effects and mechanisms of action of the ergopeptides ergotamine and ergovaline and the effects of peramine on reticulum motility of sheep. Am J Vet Res. 2009 Feb; 70(2):270-6 ...
Benzothiepins D3.438.197 D3.633.100.197 Benzoxazines D3.438.209 D3.633.100.209 Benzoxazoles D3.438.221 D3.633.100.221 ...
Comparative Study 2009; 30(Suppl 1): 133-136 PubMed PMID: 20027159 Keywords: Benzothiepins:pharmacology, Brompheniramine: ...
Comparative Study 2009; 30(Suppl 1): 133-136 PubMed PMID: 20027159 Keywords: Benzothiepins:pharmacology, Brompheniramine: ...
Fischer A, Strek ME, Cottin V, Dellaripa PF, Bernstein EJ, Brown KK, Danoff SK, Distler O, Hirani N, Jones KD, Khanna D, Lee JS, Lynch DA, Maher TM, Millar AB, Raghu G, Silver RM, Steen VD, Volkmann ER, Mullan RH, ODwyer DN, Donnelly SC. Proceedings of the American College of Rheumatology/Association of Physicians of Great Britain and Ireland Connective Tissue Disease-Associated Interstitial Lung Disease Summit: A Multidisciplinary Approach to Address Challenges and Opportunities. Arthritis Rheumatol. 2019 02; 71(2):182-195 ...
Robichaux JP, Elamin YY, Vijayan RSK, Nilsson MB, Hu L, He J, Zhang F, Pisegna M, Poteete A, Sun H, Li S, Chen T, Han H, Negrao MV, Ahnert JR, Diao L, Wang J, Le X, Meric-Bernstam F, Routbort M, Roeck B, Yang Z, Raymond VM, Lanman RB, Frampton GM, Miller VA, Schrock AB, Albacker LA, Wong KK, Cross JB, Heymach JV. Pan-Cancer Landscape and Analysis of ERBB2 Mutations Identifies Poziotinib as a Clinically Active Inhibitor and Enhancer of T-DM1 Activity. Cancer Cell. 2019 10 14; 36(4):444-457.e7 ...
Cavallo D, Rudy D, Mohammadi A, Macri J, Adeli K. Studies on degradative mechanisms mediating post-translational fragmentation of apolipoprotein B and the generation of the 70-kDa fragment. J Biol Chem. 1999 Aug 13; 274(33):23135-43 ...
This is a multicentre, extension study of LUM001 in children diagnosed with Alagille Syndrome who have completed participation in a core LUM001 treatment
This graph shows the total number of publications written about "Quinolizines" by people in Harvard Catalyst Profiles by year, and whether "Quinolizines" was a major or minor topic of these publication ...
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Brandy Y, Ononiwu I, Adedeji D, Williams V, Mouamba C, Kanaan Y, Copeland RL, Wright DA, Butcher RJ, Denmeade SR, Bakare O. Synthesis and cytotoxic activities of some 2-arylnaphtho[2,3-d]oxazole-4,9-dione derivatives on androgen-dependent (LNCaP) and androgen-independent (PC3) human prostate cancer cell lines. Invest New Drugs. 2012 Aug; 30(4):1709-14 ...
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