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BenzothiazolesThiazolesCytochrome P-450 CYP1A1Antineoplastic AgentsHalogensAniline CompoundsMolecular StructureHydrogenAlkylationMarketingResearch ReportFoundations
Benzothiazoles
Compounds with a benzene ring fused to a thiazole ring.
Thiazoles
Cytochrome P-450 CYP1A1
A liver microsomal cytochrome P-450 monooxygenase capable of biotransforming xenobiotics such as polycyclic hydrocarbons and halogenated aromatic hydrocarbons into carcinogenic or mutagenic compounds. They have been found in mammals and fish. This enzyme, encoded by CYP1A1 gene, can be measured by using ethoxyresorufin as a substrate for the ethoxyresorufin O-deethylase activity.
Antineoplastic Agents
Substances that inhibit or prevent the proliferation of NEOPLASMS.
Halogens
A family of nonmetallic, generally electronegative, elements that form group 17 (formerly group VIIa) of the periodic table.
Aniline Compounds
Molecular Structure
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
Hydrogen
The first chemical element in the periodic table. It has the atomic symbol H, atomic number 1, and atomic weight [1.00784; 1.00811]. It exists, under normal conditions, as a colorless, odorless, tasteless, diatomic gas. Hydrogen ions are PROTONS. Besides the common H1 isotope, hydrogen exists as the stable isotope DEUTERIUM and the unstable, radioactive isotope TRITIUM.
Alkylation
The covalent bonding of an alkyl group to an organic compound. It can occur by a simple addition reaction or by substitution of another functional group.
Marketing
Activity involved in transfer of goods from producer to consumer or in the exchange of services.
Research Report
Detailed account or statement or formal record of data resulting from empirical inquiry.
Foundations
Organizations established by endowments with provision for future maintenance.

Both the antioxidant and D3 agonist actions of pramipexole mediate its neuroprotective actions in mesencephalic cultures. (1/804)

Pramipexole (PPX) is a full intrinsic activity, direct-acting dopamine (DA) agonist possessing 7-fold higher affinity for D3 than for D2 receptors. It also is a potent antioxidant. PPX was previously shown to be neuroprotective because it dose dependently attenuated the DA neuron loss produced by levodopa in mesencephalic cultures. Several different drugs with properties similar to PPX were studied here to better understand the mechanism or mechanisms responsible for this neuroprotective effect. The D3-preferring agonist 7-hydroxy-diphenylaminotetralin (7-OH-DPAT) and the D3 antagonist U99194, respectively, increased and decreased the neuroprotective effects of PPX in a dose-dependent fashion. Addition of the selective D2 agonist U95666 or the D2/D3 antagonists domperidone or raclopride did not affect PPX's neuroprotective effect. Interestingly, 7-OH-DPAT by itself did not attenuate the DA neuron loss produced by levodopa. However, when 7-OH-DPAT was combined with a low dose of the antioxidants U101033E or alpha-tocopherol, the toxic effects of levodopa were attenuated. Similar results were observed when the D3-preferring agonist PD128, 907 was studied. In addition, media conditioned by exposure of mesencephalic cultures incubated with all D3-preferring agonists studied was shown to enhance the growth of DA neurons in freshly harvested recipient cultures implicating a D3-mediated trophic activity in the neuroprotective effect. These data suggest that PPX's neuroprotective actions in the levodopa toxicity model are a consequence of its combined actions as a D3 receptor agonist and an antioxidant.  (+info)

Aldose reductase functions as a detoxification system for lipid peroxidation products in vasculitis. (2/804)

Giant cell arteritis (GCA) is a systemic vasculitis preferentially affecting large and medium-sized arteries. Inflammatory infiltrates in the arterial wall induce luminal occlusion with subsequent ischemia and degradation of the elastic membranes, allowing aneurysm formation. To identify pathways relevant to the disease process, differential display-PCR was used. The enzyme aldose reductase (AR), which is implicated in the regulation of tissue osmolarity, was found to be upregulated in the arteritic lesions. Upregulated AR expression was limited to areas of tissue destruction in inflamed arteries, where it was detected in T cells, macrophages, and smooth muscle cells. The production of AR was highly correlated with the presence of 4-hydroxynonenal (HNE), a toxic aldehyde and downstream product of lipid peroxidation. In vitro exposure of mononuclear cells to HNE was sufficient to induce AR production. The in vivo relationship of AR and HNE was explored by treating human GCA temporal artery-severe combined immunodeficiency (SCID) mouse chimeras with the AR inhibitors Sorbinil and Zopolrestat. Inhibition of AR increased HNE adducts twofold and the number of apoptotic cells in the arterial wall threefold. These data demonstrate that AR has a tissue-protective function by preventing damage from lipid peroxidation. We propose that AR is an oxidative defense mechanism able to neutralize the toxic effects of lipid peroxidation and has a role in limiting the arterial wall injury mediated by reactive oxygen species.  (+info)

Efficacy, safety, and tolerance of the non-ergoline dopamine agonist pramipexole in the treatment of advanced Parkinson's disease: a double blind, placebo controlled, randomised, multicentre study. (3/804)

OBJECTIVES: Pramipexole, a non-ergot dopamine D2/D3 receptor agonist, was investigated as an add on drug in advanced parkinsonian patients with motor fluctuations to assess efficacy, safety, and tolerance. METHODS: Seventy eight patients of either sex with advanced Parkinson's disease and treatment complications such as motor fluctuations were enrolled into a double blind, placebo controlled, randomised, multicentre study (phase II) and assigned to add on treatment with pramipexole (n=34) versus placebo (n=44) to a previously stabilised antiparkinsonian medication (7 week dose titration interval, 4 week maintenance period). The primary end point of efficacy was the change from baseline in the total score of the unified Parkinson's disease rating scale (UPDRS) in the on "period" (2 hours after intake of study medication). Safety and tolerability were assessed on the basis of adverse events, vital signs, laboratory measurements, and ECG recordings. RESULTS: There was a significant improvement of the pramipexole group in UPDRS total scores, subscores part II, III (activities of daily living and motor examination), and IV (complications of therapy). Mean UPDRS total score decreased by 37.3% under pramipexole compared with 12.2% under placebo (p<0.001). Patients under pramipexole reported an overall reduction in "off" periods of 12%--resulting in 1.7 more hours "on" time a day--compared with an increase in "off" periods of 2% under placebo. There were no unexpected safety results. The adverse event profile disclosed a high tolerability. The most important adverse events under pramipexole were fatigue, dyskinesia, and vivid dreams. CONCLUSION: Pramipexole administration is an efficacious and well tolerated add on therapy in patients with advanced Parkinson's disease with an improvement in activities of daily living, motor function, and treatment associated complications.  (+info)

Primary active transport of organic anions on bile canalicular membrane in humans. (4/804)

Biliary excretion of several anionic compounds was examined by assessing their ATP-dependent uptake in bile canalicular membrane vesicles (CMV) prepared from six human liver samples. 2, 4-Dinitrophenyl-S-glutathione (DNP-SG), leukotriene C4 (LTC4), sulfobromophthalein glutathione (BSP-SG), E3040 glucuronide (E-glu), beta-estradiol 17-(beta-D-glucuronide) (E2-17G), grepafloxacin glucuronide (GPFXG), pravastatin, BQ-123, and methotrexate, which are known to be substrates for the rat canalicular multispecific organic anion transporter, and taurocholic acid (TCA), a substrate for the bile acid transporter, were used as substrates. ATP-dependent and saturable uptake of TCA, DNP-SG, LTC4, E-glu, E2-17G, and GPFXG was observed in all human CMV preparations examined, suggesting that these compounds are excreted in the bile via a primary active transport system in humans. Primary active transport of the other substrates was also seen in some of CMV preparations but was negligible in the others. The ATP-dependent uptake of all the compounds exhibited a large inter-CMV variation, and there was a significant correlation between the uptake of glutathione conjugates (DNP-SG, LTC4, and BSP-SG) and glucuronides (E-glu, E2-17G, and GPFXG). However, there was no significant correlation between TCA and the other organic anions, implying that the transporters for TCA and for organic anions are different also in humans. When the average value for the ATP-dependent uptake by each preparation of human CMVs was compared with that of rat CMVs, the uptake of glutathione conjugates and nonconjugated anions (pravastatin, BQ-123, and methotrexate) in humans was approximately 3- to 76-fold lower than that in rats, whereas the uptake of glucuronides was similar in the two species. Thus there is a species difference in the primary active transport of organic anions across the bile canalicular membrane that is less marked for glucuronides.  (+info)

Kinetic control of multiple forms of Ca(2+) spikes by inositol trisphosphate in pancreatic acinar cells. (5/804)

The mechanisms of agonist-induced Ca(2+) spikes have been investigated using a caged inositol 1,4,5-trisphosphate (IP(3)) and a low-affinity Ca(2+) indicator, BTC, in pancreatic acinar cells. Rapid photolysis of caged IP(3) was able to reproduce acetylcholine (ACh)-induced three forms of Ca(2+) spikes: local Ca(2+) spikes and submicromolar (<1 microM) and micromolar (1-15 microM) global Ca(2+) spikes (Ca(2+) waves). These observations indicate that subcellular gradients of IP(3) sensitivity underlie all forms of ACh-induced Ca(2+) spikes, and that the amplitude and extent of Ca(2+) spikes are determined by the concentration of IP(3). IP(3)-induced local Ca(2+) spikes exhibited similar time courses to those generated by ACh, supporting a role for Ca(2+)-induced Ca(2+) release in local Ca(2+) spikes. In contrast, IP(3)- induced global Ca(2+) spikes were consistently faster than those evoked with ACh at all concentrations of IP(3) and ACh, suggesting that production of IP(3) via phospholipase C was slow and limited the spread of the Ca(2+) spikes. Indeed, gradual photolysis of caged IP(3) reproduced ACh-induced slow Ca(2+) spikes. Thus, local and global Ca(2+) spikes involve distinct mechanisms, and the kinetics of global Ca(2+) spikes depends on that of IP(3) production particularly in those cells such as acinar cells where heterogeneity in IP(3) sensitivity plays critical role.  (+info)

Attenuation of ischemia induced increases in sodium and calcium by the aldose reductase inhibitor zopolrestat. (6/804)

OBJECTIVE: We have previously demonstrated that zopolrestat, an inhibitor of the enzyme aldose reductase, reduces ischemic injury in hearts from diabetic and non-diabetic rats. To further explore potential cardioprotective mechanisms of zopolrestat, we measured changes in intracellular sodium, calcium, and Na+,K(+)-ATPase activity in zopolrestat treated hearts during ischemia and reperfusion. METHODS: Hearts from acute diabetic (Type I) and age-matched control rats were isolated and retrogradely perfused. Hearts had either control perfusion or exposure to 1 microM zopolrestat for 10 min, followed by 20 min of global ischemia and 60 min of reperfusion. Changes in intracellular sodium and calcium were measured using 23Na and 19F magnetic resonance spectroscopy, respectively, while the activity of Na+,K(+)-ATPase was measured using biochemical assays. RESULTS: Zopolrestat blunted the rise in [Na]i during ischemia in both diabetic hearts and non-diabetic hearts. The end-ischemic [Na]i was 21.3 +/- 2.6 mM in the zopolrestat treated diabetics and 25.9 +/- 2.3 in zopolrestat treated non-diabetics, versus 31.6 +/- 2.6 mM and 32.9 +/- 2.8 mM in the untreated diabetics and untreated non-diabetics, respectively, (P = 0.002). Similarly, the rise in [Ca]i at the end of ischemia was significantly reduced in zopolrestat treated diabetic and non-diabetic hearts (P = 0.005). Zopolrestat increased the activity of Na-,K(+)-ATPase in diabetic hearts under baseline conditions (11.70 +/- 0.95 versus 7.28 +/- 0.98 mumol/h/mg protein, P = 0.005) as well as during ischemia and reperfusion. Similar changes in Na+,K(+)-ATPase activity were also observed in non-diabetic hearts. CONCLUSIONS: The data provide additional support to the protective effects of zopolrestat and suggest that a possible mechanism of action may be associated with the attenuation of the rise in [Na]i and [Ca]i during ischemia and reperfusion.  (+info)

Antioxidant activity: what do we measure? (7/804)

Inhibition of oxidation of 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) by free radicals generated by decomposition of 2,2'-azobis(2-amidopropane) (ABAP) by antioxidants and biological material was studied. A correlation was found between the ability of various substances to delay the onset of ABTS oxidation and their rapid reduction of the ABTS+* cation radical, and between the ability to reduce the maximal rate of ABTS oxidation and slow reduction of ABTS+*. The length of the lag period of ABTS oxidation was found to be independent of ABTS concentration. Similar decrease of peroxynitrite-induced ABTS+* formation by antioxidants was observed when the antioxidants were added before and after peroxynitrite. All these findings indicate that the main effect of antioxidants in this system is reduction of ABTS+* and not prevention of its formation. Reduction of oxidation products rather than inhibition of their formation may be the predominant mode of action of antioxidants in various assays of antioxidant activity.  (+info)

Malaria vectors in a traditional dry zone village in Sri Lanka. (8/804)

Malaria transmission by anopheline mosquitoes was studied in a traditional tank-irrigation-based rice-producing village in the malaria-endemic low country dry zone of northcentral Sri Lanka during the period August 1994-February 1997. Adult mosquitoes were collected from human and bovid bait catches, bovid-baited trap huts, indoor catches, and pit traps. Mosquito head-thoraces were tested for the presence of Plasmodium falciparum and P. vivax, and blood-engorged abdomens for the presence of human blood by ELISAs. House surveys were done at two-day intervals to record cases of blood film-confirmed malaria among the villagers. A total of 7,823 female anophelines representing 14 species were collected. Trends in anopheline abundance were significantly correlated with rainfall of the preceding month in An. annularis, An. barbirostris, An. subpictus, An. vagus, and An. varuna, but were not significant in An. culicifacies and An. peditaeniatus. Malaria parasite infections were seen in seven mosquito species, with 75% of the positive mosquitoes containing P. falciparum and 25% P. vivax. Polymorph PV247 was recorded from a vector (i.e., An. varuna) for the first time in Sri Lanka. Computations of mean number of infective vector (MIV) rates using abundance, circumsporozoite (CS) protein rate, and human blood index (HBI) showed the highest rate in An. culicifacies. A malaria outbreak occurred from October 1994 to January 1995 in which 45.5% of village residents experienced at least a single disease episode. Thereafter, malaria incidence remained low. Anopheles culicifacies abundance lagged by one month correlated positively with monthly malaria incidence during the outbreak period, and although this species ranked fifth in terms of abundance, infection was associated with a high MIV rate due to a high CS protein rate and HBI. Abundance trends in other species did not correlate significantly with malaria. It was concluded that An. culicifacies was epidemiologically the most important vector in the study area.  (+info)

Benzothiazole derivatives, processes for their preparation and pharmaceutical compositions containing these compounds -...Benzothiazole derivatives, processes for their preparation and pharmaceutical compositions containing these compounds -...
Benzothiazole derivatives corresponding to the general formula I ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 represent, independently of one another, a hydrogen atom, a halogen atom, a linear C.sub.1 -C.sub.3 -alkyl group or a linear C.sub.1 -C.sub.3 -alkoxy group, R.sup.5 represents a hydrogen atom or a linear C.sub.1 -C.sub.3 -alkyl group, R.sup.6 represents a hydrogen atom, and R.sup.7 represents a formyl group, a carbalkoxy group of the formula ##STR2## wherein R.sup.8 denotes a linear or branch chained C.sub.1 -C.sub.4 -alkyl group, or it represents an acyl group of the formula ##STR3## wherein R.sup.9 denotes a linear C.sub.1 -C.sub.3 -alkyl group, or R.sup.6 and R.sup.7 together represent the group ##STR4## wherein R.sup.10 and R.sup.11 represent, independently of one another, a hydrogen atom or a linear C.sub.1 -C.sub.6 -alkyl group or R.sup.6 and R.sup.7 represent the group ##STR5## wherein R.sup.12 and R.sup
http://www.patentgenius.com/patent/4732986.html
2-methyl-5-(trifluoromethyl)-1,3-benzothiazole 398-99-2 H-NMR | C-NMR Spectral Analysis NMR Spectrum2-methyl-5-(trifluoromethyl)-1,3-benzothiazole 398-99-2 H-NMR | C-NMR Spectral Analysis NMR Spectrum
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CAS No.49790-72-9,Benzothiazole, 2-[[(5-nitro-2-furanyl)methyl]thio]- SuppliersCAS No.49790-72-9,Benzothiazole, 2-[[(5-nitro-2-furanyl)methyl]thio]- Suppliers
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benzothiazole 95-16-9 MSDS, Safety Technical Specifications MSDSbenzothiazole 95-16-9 MSDS, Safety Technical Specifications MSDS
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Synthesis and structural studies of novel benzothiazole derivative and evaluation of their antimicrobial activity| AbstractSynthesis and structural studies of novel benzothiazole derivative and evaluation of their antimicrobial activity| Abstract
Benzothiazole are important group of compounds reported to have various biological activities and hence the present study was undertaken in order to s..
http://www.derpharmachemica.com/abstract/synthesis-and-structural-studies-of-novel-benzothiazole-derivativernand-evaluation-of-their-antimicrobial-activity-11052.html
Benzothiazole, 2-(chloromethyl)-5-methyl- (7CI,8CI,9CI) (CAS 5717-91-9) Market Research Report 2017Benzothiazole, 2-(chloromethyl)-5-methyl- (7CI,8CI,9CI) (CAS 5717-91-9) Market Research Report 2017
The report generally describes benzothiazole, 2-(chloromethyl)-5-methyl- (7ci,8ci,9ci), examines its uses, production methods, patents. Benzothiazole,
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Benzothiazole, 4-nitro- (6CI,7CI,8CI,9CI) (CAS 2942-08-7) Market Research Report 2018Benzothiazole, 4-nitro- (6CI,7CI,8CI,9CI) (CAS 2942-08-7) Market Research Report 2018
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Design, synthesis, biological evaluation and preliminary mechanism study of novel benzothiazole derivatives bearing indole...Design, synthesis, biological evaluation and preliminary mechanism study of novel benzothiazole derivatives bearing indole...
Sigma-Aldrich offers abstracts and full-text articles by [Junjie Ma, Guanglong Bao, Limei Wang, Wanting Li, Boxuan Xu, Baoquan Du, Jie Lv, Xin Zhai, Ping Gong].
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The Effect Of The Dopamine Agonist Pramipexole On Measures Of Impulsiv by Daniel GlizerThe Effect Of The Dopamine Agonist Pramipexole On Measures Of Impulsiv by Daniel Glizer
Patients with Parkinson disease are prescribed dopamine agonists such as pramipexole to improve motor symptoms. Several studies have found that patients taking dopaminergic medication develop impulse control disorders. In contrast, other studies suggest that some behaviors become less impulsive with pramipexole. We evaluated the performance of 20 young, healthy participants who received pramipexole (0.5 mg) and 20 participants who received placebo, on the Go/No-Go, the Stop Signal Task, and the Balloon Analogue Risk Task. We found that the pramipexole group had more timed out Go trials on the Go/No-Go task than the placebo group, suggesting reduced motor impulsivity. There were no differences between the two groups performance on the other impulsivity tasks. This pattern of results is in line with the theory that impulsivity consists of a motor and a cognitive aspect, and that pramipexole might decrease motor, but not cognitive impulsivity.
https://ir.lib.uwo.ca/etd/4945/
IUCr) 7H-[1,2]Benzo-thia-zolo[3,2-b]quinazoline 5,5-dioxideIUCr) 7H-[1,2]Benzo-thia-zolo[3,2-b]quinazoline 5,5-dioxide
Saccharin belongs to a class of cyclic sulfonamides and this is used as an artificial sweetener for a longtime. The benzothiazole and quinazoline derivatives form an important classes of fused heterocyclic compounds with a wide range of biological activities such as antimicrobial (Schwartz et al., 1992), anticancer (Wolfe et al., 1990), antiinflammatory (Tereshima et al., 1995). As a part of our studies in this area, the molecular and crystal structures of the title compound have been determined and the results are presented here.. The title compound comprises a benzothiazole ring fused with quinazoline ring. X-ray analysis confirms the molecular structure and atom connectivity as illustrated in Fig. 1. The benzothiazole ring system is essentially planar with a maximum deviation of -0.0127 (16)Å for the C7 atom. The quinazoline ring system is also essentially planar with the maximum deviation of -0.1588 (15)Å for the N1 atom. The dihedral angle between the benzothiazole and quinazoline ring ...
http://journals.iucr.org/e/issues/2012/11/00/rk2382/index.html
Benzothiazole,2,3-dihydro-,1-oxide - Alfa ChemistryBenzothiazole,2,3-dihydro-,1-oxide - Alfa Chemistry
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Design, Synthesis and Biological Evaluation of Benzo[D]Thiazole with Dimethylpyrazol DerivativesDesign, Synthesis and Biological Evaluation of Benzo[D]Thiazole with Dimethylpyrazol Derivatives
A series of new benzothiazole derivatives containing dimethylpyrazole were synthesized and evaluated for their anticonvulsant activity, neurotoxicity and cytotoxicity by using the maximal electroshock (MES), rotarod neurotoxicity (TOX) and MTT colorimetric assay. Among the compounds studied, four compounds (6a, 6b, 6g and 6m) showed better anticonvulsant than the others at 300 mg/kg and they also showed anticonvulsant activity at the dose of 100 mg/kg. All the synthetic compounds showed lower neurotoxicity and little cytotoxicity, so that the compounds, which with better activities, also had higher protective index. In particular, the compound 6g, 2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-((2-fluorobenzyl)oxy)benzo[d]thiazole showed better activity with an ED50 value of 160.4 mg/kg and higher protective index (PI) values of 2.74 in the MES test than the standard drugs sodium valproate, which used as positive controls in this study. After that the compound 6g demonstrated antagonistic activity against seizures
http://journal.waocp.org/article_88821.html
3-Ethyl-2-[[3-[3-[3-[(3-ethyl-1,3-benzothiazol-2-ylidene)methyl]-5,5-dimethylcyclohex-2-en-1-ylidene]prop-1-enyl]-5,5...3-Ethyl-2-[[3-[3-[3-[(3-ethyl-1,3-benzothiazol-2-ylidene)methyl]-5,5-dimethylcyclohex-2-en-1-ylidene]prop-1-enyl]-5,5...
3-Ethyl-2-[[3-[3-[3-[(3-ethyl-1,3-benzothiazol-2-ylidene)methyl]-5,5-dimethylcyclohex-2-en-1-ylidene]prop-1-enyl]-5,5-dimethylcyclohex-2-en-1-ylidene]methyl]-1,3-benzothiazol-3-ium iodide/ACM15979198 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
http://www.alfa-chemistry.com/cas_15979-19-8.htm
2-Mercaptobenzothiazole Degradation Pathway2-Mercaptobenzothiazole Degradation Pathway
This pathway was started by Janice Frias, University of Minnesota, BioC/MicE 5309, and completed by Carla Essenberg and Jiun-guo Yu, University of Minnesota. 2-Mercaptobenzothiazole (MBT) is used primarily as a vulcanization accelerator in the production of rubber, although it is also used to inhibit the corrosion of copper in water and as an ingredient in cutting oils and petroleum products (Whittaker et al., 2004, De Wever et al., 1998). The manufacture of MBT produces wastewaters with high levels of MBT and its derivatives, and these compounds can also be released into water by factories using MBT and by leaching from MBT-containing products, particularly rubber (De Wever et al., 1998). Many other industries also use benzothiazoles, which in some cases degrade to MBT. For example, MBT is a degradation product of a fungicide widely used in the leather and lumber industries, 2-(thiocyanomethylthio)benzothiazole (Reemtsma, Fiehn, Kalnowski, and Jekel (1995) Environ Sci Technol 29:478-485). MBT ...
http://eawag-bbd.ethz.ch/mbt/mbt_map.html
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Plus itPlus it
NVP-231: A Competitive CerK Inhibitor. We developed a homogeneous CerK assay for high-throughput screening based on a luminescent reaction measuring ATP consumption (Koresawa and Okabe, 2004; Klumpp et al., 2006). After miniaturization of this assay to a 1536-well plate format, we screened over a million compounds for inhibition of CerK. Primary hits active in the micromolar range were confirmed or invalidated by dose-response experiments, which also provided a preliminary ranking. The overlap to hit lists from other kinase inhibitor screens using the same assay principle was very limited, indicating specificity of the hit compounds for CerK. Although the screened libraries contained many typical protein kinase inhibitors, only a few of them inhibited CerK. Further hit validation was conducted using a direct enzymatic assay measuring the incorporation of radioactive phosphate into C1P.. One of the compounds identified as the benzothiazole derivative 1 (or NVP-231) showed an IC50 value of 12 ± 2 ...
http://molpharm.aspetjournals.org/content/74/4/925
2-(1,2-benzothiazol-3-yl)ethyl acetate | C11H11NO2S - PubChem2-(1,2-benzothiazol-3-yl)ethyl acetate | C11H11NO2S - PubChem
2-(1,2-benzothiazol-3-yl)ethyl acetate | C11H11NO2S | CID 590633 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
https://pubchem.ncbi.nlm.nih.gov/compound/590633
2-[3-(1,1-Dioxo-2,3-dihydro-1,2-benzothiazol-3-yl)-2-methylindol-1-yl]acetic acid | C18H16N2O4S - PubChem2-[3-(1,1-Dioxo-2,3-dihydro-1,2-benzothiazol-3-yl)-2-methylindol-1-yl]acetic acid | C18H16N2O4S - PubChem
2-[3-(1,1-Dioxo-2,3-dihydro-1,2-benzothiazol-3-yl)-2-methylindol-1-yl]acetic acid | C18H16N2O4S | CID 46890687 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
https://pubchem.ncbi.nlm.nih.gov/compound/46890687
1-4-6-dimethyl-1-3-benzothiazol-2-yl-piperidine-3-carboxylic-acid | VWR1-4-6-dimethyl-1-3-benzothiazol-2-yl-piperidine-3-carboxylic-acid | VWR
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RCSB PDB - 4AJN: rat LDHA in complex with 2-((4-(2-((3-((2-methyl-1,3-benzothiazol-6- yl)amino)-3-oxo-propyl)carbamoylamino...RCSB PDB - 4AJN: rat LDHA in complex with 2-((4-(2-((3-((2-methyl-1,3-benzothiazol-6- yl)amino)-3-oxo-propyl)carbamoylamino...
4AJN: rat LDHA in complex with 2-((4-(2-((3-((2-methyl-1,3-benzothiazol-6- yl)amino)-3-oxo-propyl)carbamoylamino)ethyl)phenyl)methyl) propanedioic acid
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N-(1,3-benzothiazol-2-ylmethyl)benzamide | C15H12N2OS - ChemSynthesisN-(1,3-benzothiazol-2-ylmethyl)benzamide | C15H12N2OS - ChemSynthesis
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Experimental and Density Functional Theoretical Studies on the Spectra of <i>N</i>, <i>N</i>-di[3-hydroxy-4-(2...Experimental and Density Functional Theoretical Studies on the Spectra of <i>N</i>, <i>N</i>-di[3-hydroxy-4-(2...
Abstract: The experimental infrared (IR), nuclear magnetic resonance (NMR), and ultraviolet (UV) spectra, and density functional theory (DFT) calculations of the novel compound N, N-di[3-hydroxy-4-(2-benzothiazole) phenyl]urea (4-DHBTU) are presented. Compared with the UV spectra of the 2-(4-amino-2-hydroxyphenyl) benzothiazole (4-AHBT) monomer, the experimental spectra of 4-DHBTU, a dimer of 4-AHBT, show dualwavelength absorption with significantly enhanced absorption intensity and an obvious red shift of the maximum absorption peak. Analysis of the experimental spectra and the DFT calculations shows that the structures of cis-C11 and trans-C11 are the two most stable conformers, and that the main reason for the different UV spectral properties of the dimer and monomer is the coexistence of cis-C11, trans-C11, cis-C22, and trans-C22 in the 4-DHBTU sample. In addition, the DFT calculations indicate that a hydrogen-bonding interaction between 4-DHBTU and the dimethyl sulfoxide (DMSO) solvent ...
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Small-conductance (KCa2) and intermediate-conductance (KCa3.1) calcium-activated K+ channels are voltage-independent and share a common calcium/calmodulin-mediated gating mechanism. Existing positive gating modulators like EBIO, NS309, or SKA-31 activate both KCa2 and KCa3.1 channels with similar potency or, as in the case of CyPPA and NS13001, selectively activate KCa2.2 and KCa2.3 channels. We performed a structure-activity relationship (SAR) study with the aim of optimizing the benzothiazole pharmacophore of SKA-31 toward KCa3.1 selectivity. We identified SKA-111 (5-methylnaphtho[1,2-d]thiazol-2-amine), which displays 123-fold selectivity for KCa3.1 (EC50 111 ± 27 nM) over KCa2.3 (EC50 13.7 ± 6.9 μM), and SKA-121 (5-methylnaphtho[2,1-d]oxazol-2-amine), which displays 41-fold selectivity for KCa3.1 (EC50 109 nM ± 14 nM) over KCa2.3 (EC50 4.4 ± 1.6 μM). Both compounds are 200- to 400-fold selective over representative KV (KV1.3, KV2.1, KV3.1, and KV11.1), NaV (NaV1.2, NaV1.4, NaV1.5, and ...
http://sophion.com/publications/new-positive-ca2-activated-k-channel-gating-modulators-selectivity-kca3-1/
An exploratory efficacy study of the amyloid imaging agent [F-18]flutemetamol in Japanese SubjectsAn exploratory efficacy study of the amyloid imaging agent [F-18]flutemetamol in Japanese Subjects
The criteria for diagnosing Alzheimers disease (AD) have recently been revised to include the use of biomarkers for the in vivo presence of β-amyloid, one of the neuropathological hallmarks of AD. Examples of such biomarkers are positron emission tomography (PET) β-amyloid specific ligands, including [18F]flutemetamol. The aim of this thesis was to characterize the binding properties of [18F]flutemetamol from a tracer kinetic perspective as well as by validating binding measures through comparison with tissue pathology assessments. The applicability of previously developed kinetic models of tracer binding for voxel-based analysis was examined and compared to arterial input compartment modelling, the gold standard for PET quantification. Several voxel-based methods were found to exhibit high correlations with compartment modelling, including the semi-quantitative standardized uptake value ratio (SUVR). The kinetic components of [18F]flutemetamol uptake were also investigated without model ...
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Crystal structure of (E)-2-{[(6-methoxy-1,3-benzothiazol-2-yl)imino]methyl}phenolCrystal structure of (E)-2-{[(6-methoxy-1,3-benzothiazol-2-yl)imino]methyl}phenol
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benzothiazol-2-ylthio)acetic acid - Registration Dossier - ECHAbenzothiazol-2-ylthio)acetic acid - Registration Dossier - ECHA
Preliminary irritation study: The necrosis seen at intradermal injection of the lowest concentration (2%) was considered to be caused mainly by polyethylene glycol rather than the test substance. Based on the results, the test substance concentrations selected for the main study were a 2% concentration for the intradermal induction and a 50% concentration for the epidermal induction exposure. No signs of irritation were observed to the highest test substance concentration epidermally tested. Therefore, the test site of all animals was treated with 10% SDS approximately 24 hours before the epidermal induction in the main study, to provoke a mild inflammatory reaction. A 50% test substance concentration was selected for the challenge phase. Main study results: -Induction phase: The signs of necrosis seen in the control animals after the intradermal injection with vehicle only were in consistency with the results in the preliminary irritation study after injection of polyethylene glycol. The ...
https://echa.europa.eu/sv/registration-dossier/-/registered-dossier/23238/7/5/1
benzothiazol-2-ylthio)succinic acid - Registration Dossier - ECHAbenzothiazol-2-ylthio)succinic acid - Registration Dossier - ECHA
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice ...
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benzothiazol-2-ylthio)acetic acid - Registration Dossier - ECHAbenzothiazol-2-ylthio)acetic acid - Registration Dossier - ECHA
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice ...
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2-methyl-1,2-benzothiazol-3(2|I|H|/I|)-one; [MBIT] - Registry of CLH intentions until outcome - ECHA2-methyl-1,2-benzothiazol-3(2|I|H|/I|)-one; [MBIT] - Registry of CLH intentions until outcome - ECHA
The registry of classification and labelling (CLH) intentions until outcome lists the intentions and proposals received by ECHA for a new or revised harmonised classification and labelling of a substance. The proposals are submitted by Member State competent authorities, manufacturers, importers or downstream users. Interested parties can follow the progress of a proposal through the CLH process, from the notification of the intention to the adoption of the opinion of the Committee for Risk Assessment (RAC). The advance notice enables interested parties to plan and prepare for commenting later on.. Anyone with relevant information on the identity or hazard properties of a substance is encouraged to provide this information to the dossier submitter during the early stages of the process, or at the latest during the consultation.. Where an opinion has been adopted by RAC, the status is indicated as Opinion Adopted.. Note: The classification tables for those substances that have been reviewed are ...
https://www.echa.europa.eu/et/web/guest/registry-of-clh-intentions-until-outcome/-/dislist/details/0b0236e180909261
Design and synthesis of the first generation of novel potent, selective, and in vivo active (benzothiazol-2-yl)acetonitrile...Design and synthesis of the first generation of novel potent, selective, and in vivo active (benzothiazol-2-yl)acetonitrile...
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Synthesis of 1,2,4-triazole derivatives containing benzothiazoles as pharmacologically active molecule | MetaSynthesis of 1,2,4-triazole derivatives containing benzothiazoles as pharmacologically active molecule | Meta
In attempt to make significant pharmacologically active molecule, we report here the synthesis and in vitro antimicrobial and antitubercular activity of various series of 3-(3-pyridyl)-5-(4-nitrophenyl)-4-(N-substituted-1,3-benzothiazol-2-amino)-4H-1,2,4-triazole. The antimicrobial activity of title compounds were examined against two Gram-positive bacteria (Staphylococcus aureus, Streptococcus pyogenes), two Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa), and three fungi (Candida albicans, Aspergillus niger, Aspergillus clavatus) using the broth microdilution method and antitubercular activity H(37)Rv using Lowenstein-Jensen agar method. ...
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Synthesis and Biological Evaluation of Amidine, Guanidine, and Thiourea Derivatives of 2-Amino(6-trifluoromethoxy)benzothiazole...Synthesis and Biological Evaluation of Amidine, Guanidine, and Thiourea Derivatives of 2-Amino(6-trifluoromethoxy)benzothiazole...
Close The Infona portal uses cookies, i.e. strings of text saved by a browser on the users device. The portal can access those files and use them to remember the users data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser. ...
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11C-Pittsburgh B PET Imaging in Cardiac Amyloidosis | JACC: Cardiovascular Imaging11C-Pittsburgh B PET Imaging in Cardiac Amyloidosis | JACC: Cardiovascular Imaging
Although the gold standard diagnostic tool for cardiac amyloidosis is endomyocardial biopsy (5), investigators have tried to assess this disease noninvasively with various imaging techniques. Although some molecular imaging-based methods have been successful (8,12), most of them have been unsuccessful for demonstrating amyloid deposits in the myocardium (13). The CMR has also been successful in the diagnosis of cardiac amyloidosis (14), but it may not be specific for amyloid deposits (15). Therefore, there is a clinical need to foster imaging-based diagnosis into clinical utility.. 11C-PiB has been used recently for early detection and for follow-up of Alzheimers dementia (16), a disease characterized by accumulation of β-amyloid plaque in the brain parenchyme. It is a radioactive derivative of benzothiazole that binds with conformational dependence to any type of β-amyloid sheet structure (7). Indeed, this has been demonstrated in various mouse models (17) and in human autopsy studies of the ...
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The Effect of Pramipexole on Metabolic Network Activity Compared With Levodopa in Early Parkinson's Disease - Full Text...The Effect of Pramipexole on Metabolic Network Activity Compared With Levodopa in Early Parkinson's Disease - Full Text...
CALM-PD study found that Pramipexole can reduce the occurrence of motor complication compared with Levodopa used as initiative treatment, but it still remains debatable that initiation of which medication will be better for those patients with De Novo PD.. PDRP (Parkinsons disease-related spatial covariance pattern) is a biomarker which can represent the network activity of cortico-striato-pallido-thalamocortical pathways and highly reproducible with stable network activity in individual subjects. The study published in J Neuroscience in 2010 showed that the abnormal PDRP antecede the appearance of motor signs by about 2 years, indicating PDRP might be a very promising biomarker for identifying PD at its early stage. Moreover, PDRP is able to represent the progression and severity of PD as well. It was reported that Levodopa can reduce the PD-related network activity, and the degree of network suppression correlates with the clinical improvement. However, there is no study currently showing ...
https://clinicaltrials.gov/ct2/show/NCT01470859?term=Parkinson
TOZADENANT « New Drug ApprovalsTOZADENANT « New Drug Approvals
Tozadenant RO-449351 SYN-115 Molecular Formula C19H26N4O4S Average mass 406.499 Da A2 (3); A2a-(3); RO4494351; RO4494351-000; RO4494351-002; SYN-115 Phase III clinical trials at Biotie Therapies for the treatment of Parkinsons disease as an adjunctive therapy with levodopa 1-Piperidinecarboxamide, 4-hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl- 4-Hydroxy-N-[4-methoxy-7-(4-morpholinyl)-1,3-benzothiazol-2-yl]-4-methyl-1-piperidinecarboxamide 4-Hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl-1-piperidinecarboxamide 4-Hydroxy-4-methyl-piperidine-1-carboxylic acid(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-amide CAS 870070-55-6 Originator Roche Developer Acorda Therapeutics Class Amides; Antiparkinsonians; Benzothiazoles; Carboxylic acids; Morpholines; Piperidines; Small molecules Mechanism…
https://newdrugapprovals.org/2017/08/28/tozadenant/
Food Processing | Fluid SealsFood Processing | Fluid Seals
It is inherently undesirable for any chemical component of the rubber to migrate into a foodstuff during processing or storage. Rubber compounds are complex formulations that undergo chemical transformation during vulcanisation.. Rubber components that can potentially migrate include low molecular mass monomers, vulcanising agents, plasticisers, oils and waxes and their breakdown products. For example, polar plasticisers such as di-2-ethylhexyl phthalate are readily soluble in alcohol so plasticised rubbers should not be used in contact with alcoholic beverages.. The compounds 2-mercaptobenzothiazole (MBT) and benzothiazole (BT) may migrate from rubber during the manufacture and storage of food or drink. Research has shown that this might happen. Both MBT and BT migrated from rubber into laboratory solvents.. The main types of rubber components where residues of MBT and BT may be found include natural rubber or nitrile rubber seals and gaskets used in food processing equipment. MBT is formed ...
http://www.fluidseals.com.au/applications/food-and-bevera/
Sagopilone (ZK-EPO, ZK 219477) for recurrent glioblastoma. A phase II multicenter trial by the European Organisation for...Sagopilone (ZK-EPO, ZK 219477) for recurrent glioblastoma. A phase II multicenter trial by the European Organisation for...
Stupp, R., Tosoni, A., Bromberg, J. E. C., Hau, Peter, Campone, M., Gijtenbeek, J., Frenay, M., Breimer, L., Wiesinger, H., Allgeier, A., van den Bent, M. J., Bogdahn, Ulrich, van der Graaf, W., Yun, H. J., Gorlia, T., Lacombe, D. and Brandes, A. A. (2011) Sagopilone (ZK-EPO, ZK 219477) for recurrent glioblastoma. A phase II multicenter trial by the European Organisation for Research and Treatment of Cancer (EORTC) Brain Tumor Group. Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 22 (9), pp. 2144-2149 ...
https://epub.uni-regensburg.de/29189/
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Reactions of 2,2-Azinobis-(3-ethylbenzthiazoline-6-sulfonate) dianion, ABTS 2- , with • OH, (SCN) 2 •-...Reactions of 2,2-Azinobis-(3-ethylbenzthiazoline-6-sulfonate) dianion, ABTS 2- , with • OH, (SCN) 2 •-...
Close The Infona portal uses cookies, i.e. strings of text saved by a browser on the users device. The portal can access those files and use them to remember the users data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser. ...
https://www.infona.pl/resource/bwmeta1.element.acs-doi-10_1021_jp074637h
Purpose Inhibitors from the epidermal development aspect receptor (EGFR) tyrosine kinase - Stem cell application on skin cancer...Purpose Inhibitors from the epidermal development aspect receptor (EGFR) tyrosine kinase - Stem cell application on skin cancer...
Purpose Inhibitors from the epidermal development aspect receptor (EGFR) tyrosine kinase possess demonstrated humble anticancer activity in advanced bronchioloalveolar carcinoma (BAC). launching dosage of 400 mg/m2 in week 1. The principal end stage was perseverance of response price. and mutations Pifithrin-alpha had been examined by pyrosequencing. Outcomes Seventy-two sufferers had been enrolled and 68 fulfilled eligibility requirements. Features of sufferers included median age group 71 years; sex 57 females; PS 0 or 1 88 of sufferers; and smoking position 19 never-smokers. Central pathology review verified the Pifithrin-alpha medical diagnosis in 45 of 49 obtainable specimens. Around 50% of sufferers received a lot more than two cycles of therapy (> eight weeks). Epidermis rash was the most frequent toxicity (quality 3 15 The verified response price was 7% and steady disease was seen in 35%. Pifithrin-alpha The median success and progression-free success had been 13 and 3.three months ...
http://www.exposed-skin-care.net/2016/03/31/purpose-inhibitors-from-the-epidermal-development-aspect-receptor-egfr-tyrosine-kinase/
Bioline International Official Site (site up-dated regularly)Bioline International Official Site (site up-dated regularly)
The three organometallic complexes [(Cis-Pt^II (DDH) (2,5- Dihidroxibenzensulfonic)^2, Rh^I (CO)2 Cl(2- Aminobenzothiazole) and Rh^I (CO)2 Cl(5-Cl-2- Methilbenzothiazole)] used in this study had been previously found to have a high in vitro activity against promastigote and amastigote like forms of Leishmania donovani. Here, the cytotoxic effect of these new organometallic complexes on the J-774 macrophages were studied. Only the Rh^I(CO)2 Cl (2-Aminobenzothiazole) complex induced substantial toxicity in the cells.. Also, we assayed the effect of this complex on the parasite s biosynthesis of macromolecules. The Rh^I(CO)2Cl (5-Cl-2- Methylbenzothiazole) complex inhibited DNA, RNA, and protein synthesis. On the other hand, the two other compounds tested did not inhibit the incorporation of radioactive precursors. Finally important ultrastructural alterations in the parasites treated with the two non-cytotoxic complexes were observed ...
http://www.bioline.org.br/abstract?id=oc96113&lang=en
Plus itPlus it
A number of compounds of interest as possible purine or pyrimidine antagonists have been assayed for anti-leukemic action against transplanted lymphoid leukemia (Ak 4) in mice.. The pyrimidines studied were uniformly inactive.. Of the 2,6-diaminopurine derivatives assayed, only the parent compound definitely increased survival time. Introduction of a hydroxy, mercapto, or iodo group at the 8-position of 2,6-diaminopurine apparently inactivates this anti-leukemic molecule.. Benzimidazole, 2-chloromethylbenzimidazole, 5-nitrobenzotriazole, indole, benzoxazole, benzothiazole, 2-methyl-4-hydroxyquinazoline, and 2,3,5-triphenyltetrazolium chloride were screened but showed no anti-leukemic activity.. ...
http://cancerres.aacrjournals.org/content/10/3/166
Kurt Maier College of Public HealthKurt Maier College of Public Health
Nawrocki, S. T., K. D. Drake, C. F. Watson, G. D. Foster, and K. J. Maier. (2005). Comparative aquatic toxicity evaluation of 2-(thiocyanomethylthio) benzothiazole (TCMTB) and selected degradation products using Ceriodaphnia dubia. Arch. Environ. Contam. Toxicol. 48: 344-350. Maier, K. J., J. L. Stobbe and K. D. Drake. (2003) Response to Letter to the Editor (re: Stobbe et al., 2003). International Journal of Toxicology 22:475-478. Stobbe, J. L., K. D. Drake, and K. J. Maier. (2003). Comparison of in vivo (Draize method) and in vitro (Corrositex assay) dermal corrosion values for selected industrial chemicals. International Journal of Toxicology 22:99-107. Davis, S. M., K. D. Drake, and K. J. Maier. (2002). Toxicity of boron to the duckweed, Spirodella polyrrhiza. Chemosphere. 48: 615-620. Dethloff, G. M., H. C. Bailey and K. J. Maier. (2001). Effects of dissolved copper on select hematological, biochemical and immunological parameters of wild rainbow trout (Onchrhynchus mykiss). Arch. Environ. ...
https://www.etsu.edu/cph/faculty/maierk.php
Federal Circuit affirms PTAB Mixed Decision in Acceleration Bay v. Activision BlizzardFederal Circuit affirms PTAB Mixed Decision in Acceleration Bay v. Activision Blizzard
Acceleration Bay v. Activision Blizzard. When determining if a reference was a printed publication mere indexing is insufficient. Indexing meaningful enough to provide access to the public is required. Here indexing by name and year fell short of making the reference publicly accessible.
https://www.ipwatchdog.com/2018/11/16/federal-circuit-affirms-acceleration-bay-activision-blizzard/id=103333/
Meis1: effects on motor phenotypes and the sensorimotor system in mice | Disease Models & MechanismsMeis1: effects on motor phenotypes and the sensorimotor system in mice | Disease Models & Mechanisms
Haploinsufficiency of Meis1 is a potential model system for simulating RLS in mice. Here, we show that this Meis1 deficit causes a sex- and context-dependent RLS-related phenotype at middle age, impaired sensorimotor gating ability that was refractory to the D2/3R agonist pramipexole as well as increased social memory. These behavioral abnormalities occurred without differences in thermal sensitivity, plasma iron concentrations or dopaminergic neuron number in the SNpc/VTA. Thus, although Meis1 haploinsufficiency causes the RLS-related phenotype of motor restlessness in mice, the detailed nature of these effects is complex. Furthermore, it is characteristically distinct from other genetic RLS models (e.g. Btbd9 knock-out), highlighting the heterogeneous nature of the effects of these different risk genotypes in this disease.. Motor restlessness in these Meis1-haploinsufficient mice was detected previously in young adult male and female mice (Spieler et al., 2014). RLS is, however, more prevalent ...
http://dmm.biologists.org/content/10/8/981?utm_source=DMM&utm_campaign=Nobel2017
A study evaluating efficacy of rotigotine, pramipexole LA or ropinirole CR in treating freezing of gait (FOG) in patients with...A study evaluating efficacy of rotigotine, pramipexole LA or ropinirole CR in treating freezing of gait (FOG) in patients with...
The purpose of this study is to examine how non-ergot dopamine receptor agonist (DA) treatment with rotigotine, pramipexole LA or ropinirole CR influences
http://adisinsight.springer.com/trials/700284580?error=cookies_not_supported&code=0e1d3e03-5d2e-456c-9ed9-c3d39b59d144
HORIBA ABX Pentra 120 Retic Hematology AnalyzerHORIBA ABX Pentra 120 Retic Hematology Analyzer
Description :Overview of ABX Pentra 120 ReticReticulocyte analysis is fully automated, thiazole orange staining, argon-ion laser and fluoro-flow cytometry technology is used, throughput of about 120 samples/hour (Retics or DIFF)FeaturesLiquid valves* ABX have volume accuracy and reliability. The Rotative mixing samples are efficient and smooth. Automatic sample re-run are programmable and selective (hematology factors and smears). DHSS* sequential measurement and focused flow cytometry. Balance Concept - Based on three self-determining channels leukocyte is controlled automatically. Reticulocyte profile: Argon-ion laser, fluorescence, impedance, thiazole orange. Impedance, flow cytometry, cytochemistry and absorbance are the methods of measurement used.
https://www.diagnosticequipmentstore.com/store/p75/HORIBA_ABX_Pentra_120_Retic_Hematology_Analyzer.html
I was on merapex, and now I am on the generic Pramipexole?I was on merapex, and now I am on the generic Pramipexole?
1 Answer - Posted in: restless legs syndrome, pramipexole - Answer: Sorry I dont know why the generic is so expensive. These links may help. ...
https://www.drugs.com/answers/i-was-on-merapex-and-now-i-am-on-the-generic-233239.html
Mirapex ER (Pramipexole Dihydrochloride Extended-Release Tablets): Side Effects, Interactions, Warning, Dosage & UsesMirapex ER (Pramipexole Dihydrochloride Extended-Release Tablets): Side Effects, Interactions, Warning, Dosage & Uses
Learn about Mirapex ER (Pramipexole Dihydrochloride Extended-Release Tablets) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications.
https://www.rxlist.com/mirapex-er-drug.htm
Pramipexole, help for Parkinsons disease. - Doctor SolvePramipexole, help for Parkinsons disease. - Doctor Solve
Pramipexole (Mirapex) eases the symptoms of Parkinsons disease-a progressive disorder marked by muscle rigidity, weakness, shaking, tremor. Read More!
https://www.doctorsolve.com/blog/pramipexole-help-for-parkinsons-disease/
pramipexole ER 0.375 mg tablet,extended release 24 hr | Kaiser Permanentepramipexole ER 0.375 mg tablet,extended release 24 hr | Kaiser Permanente
Pramipexole is used alone or with other medications to treat Parkinsons disease. It can improve your ability to move and can decrease shakiness (trem
https://healthy.kaiserpermanente.org/georgia/health-wellness/drug-encyclopedia/drug.pramipexole-er-0-375-mg-tablet-extended-release-24-hr.560521
Astellas pulls plug on quizartinib pact with Ambit - PharmaTimesAstellas pulls plug on quizartinib pact with Ambit - PharmaTimes
Eyebrows have been raised after Astellas Pharma decided to end its collaboration with Ambit Biosciences Corp to develop the latters acute myeloid leukaemia treatment quizartinib. - News - PharmaTimes
http://www.pharmatimes.com/news/astellas_pulls_plug_on_quizartinib_pact_with_ambit_1004613
2-(1-Methylnaphtho[1,2-d]thiazol-2(1H)-ylidene)-1-phenylethan-1-one2-(1-Methylnaphtho[1,2-d]thiazol-2(1H)-ylidene)-1-phenylethan-1-one
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam ...
http://www.chemicaldictionary.org/dic/2/2-1-Methylnaphtho-12-d-thiazol-21H-ylidene-1-phenylethan-1-one_1108.html
MEDLINE - Resultado p gina 1MEDLINE - Resultado p gina 1
Herbal medicine is an important part of health care system in most of the countries. Rubus fairholmianus is an unexplored berry in folkloric medicine. In this study, we aimed to understand the importance of R. fairholmianus in pharmaceutical industry for the development of cost-effective cancer therapeutic drugs using in vivo and in vitro analysis. Chemical characterization, antioxidant, antiproliferative and apoptosis inducing properties of R. fairholmianus root methanolic column subfraction (RFM) were investigated. The RFM displayed the presence of alpha-tocopherol, flavonol glycoside and apigenin in the chemical characterization. DPPH (2, 2-diphenyl-1-picrylhydrazyl) and ABTS (2, 2-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid)) radical scavenging assays exhibited an activity of 7.56 g/mL (IC ) and 20514.7 M trolox equivalents/g respectively. The solid and ascites tumors in mice were reduced significantly upon 100 mg/kg RFM treatment by reducing the tumor volume (1.86 cm ), tumor weight ...
http://bases.bireme.br/cgi-bin/wxislind.exe/iah/online/?IsisScript=iah/iah.xis&nextAction=lnk&base=MEDLINE&lang=p&format=detailed.pft&indexSearch=EX&exprSearch=B01.650.940.800.575.912.250.859.937.500.764
FDA approves Boehringer Ingelheim s pramipexole for the treatment of moderate-to-severe primary Restless Legs Syndrome (RLS) |...FDA approves Boehringer Ingelheim s pramipexole for the treatment of moderate-to-severe primary Restless Legs Syndrome (RLS) |...
Millions of people worldwide living with RLS to benefit as treatment becomes globally available, , , , Ingelheim/Germany, 10 November 2006 - Boehringer Ingelheim announced today that the U.S. Food and Dr...
https://www.webwire.com/ViewPressRel.asp?aId=23520
Lysine linkage in abasic site-binding ligand-thiazole orange conjugates for improved binding affinity to orphan nucleobases in...Lysine linkage in abasic site-binding ligand-thiazole orange conjugates for improved binding affinity to orphan nucleobases in...
Introduction of lysine linkage in the conjugate between abasic site-binding ligands and thiazole orange significantly improved the binding affinity for target orphan adenine or uracil nucleobase in DNA/RNA hybrids.
http://pubs.rsc.org/en/Content/ArticleLanding/2016/CC/C6CC07236D
Gentaur Molecular :EYlabs \ Aminophenyl a Galactose Gel, 5mL \ CG-032-5Gentaur Molecular :EYlabs \ Aminophenyl a Galactose Gel, 5mL \ CG-032-5
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PatientsLikeMe | Evaluations from Patients who take PramipexolePatientsLikeMe | Evaluations from Patients who take Pramipexole
The worlds largest personalized health network that helps people find new treatments, connect with others and take action to improve their outcomes.
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Mirapex ER Dosage Guide - Drugs.comMirapex ER Dosage Guide - Drugs.com
Detailed dosage guidelines and administration information for Mirapex ER (pramipexole dihydrochloride). Includes dose adjustments, warnings and precautions.
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Molcan :: Product DetailsMolcan :: Product Details
2-((2-Aminophenyl)thio)phenyl)(4-(2-(2-hydroxyethoxy)ethyl)piperazin-1-yl)methanone ;. CAS # 848814-27-7 ;. C21H27N3O3S ;. MW: 401.52 ;. ...
http://molcan.com/products/3272
Potassium ferricyanidePotassium ferricyanide
Würfel, Hendryk; Jakobi, Dörthe (2018). "Syntheses of Substituted 2-Cyano-benzothiazoles". Organic Syntheses. 95: 177-191. doi: ...
https://en.wikipedia.org/wiki/Potassium_ferricyanide
SulfathiazoleSulfathiazole
Rouf A, Tanyeli C (June 2015). "Bioactive thiazole and benzothiazole derivatives". European Journal of Medicinal Chemistry. 97 ...
https://en.wikipedia.org/wiki/Sulfathiazole
TCMTBTCMTB
Benzothiazol-2-ylthio)methyl thiocyanate (TCMTB) is a chemical compound classified as a benzothiazole. TCMTB is an oily, ... EPA: Reregistration Eligibility Decision for 2- (thiocyanomethylthio) benzothiazoles (TCMTB) (PDF; 2.7 MB), August 2006. Engin ... benzothiazole , CH = DB , A = DB , D = DB , 8 March 2016. ...
https://en.wikipedia.org/wiki/TCMTB
ErythrobacterErythrobacter
Hu, Youcai; MacMillan, John B. (16 December 2011). "Erythrazoles A-B, Cytotoxic Benzothiazoles from a Marine-Derived ...
https://en.wikipedia.org/wiki/Erythrobacter
Surendra Nath PandeyaSurendra Nath Pandeya
His research focused on semicarbazones, Mannich bases, thiadiazoles, benzothiazoles, and oxindole compounds. Dr. S.N. Pandeya ...
https://en.wikipedia.org/wiki/Surendra_Nath_Pandeya
ThiazoleThiazole
... s are found in a variety of specialized products, often fused with benzene derivatives, the so-called benzothiazoles. ... The following anthroquinone dyes contain benzothiazole subunits: Algol Yellow 8 (CAS# [6451-12-3]), Algol Yellow GC (CAS# [129- ... Other important thiazole derivatives are benzothiazoles, for example, the firefly chemical luciferin. Whereas thiazoles are ...
https://en.wikipedia.org/wiki/Thiazole
PrimulinePrimuline
... is a dye containing the benzothiazole ring system. Primuline itself is also known as Direct yellow 7, Carnotine, or C ...
https://en.wikipedia.org/wiki/Primuline
Julia olefinationJulia olefination
The most popular example is the benzothiazole sulfone.[14] The reaction of the benzothiazole sulfone (1) with lithium ... It proceeds with the same mechanism as the benzothiazole sulfone above. The high E-selectivity of the Julia-Kocienski ... Since the benzothiazole variation of the Julia olefination does not involve equilibrating intermediates, the stereochemical ...
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Arie Lev GruzmanArie Lev Gruzman
"Benzothiazole derivatives augment glucose uptake in skeletal muscle cells and stimulate insulin secretion from pancreatic β- ... "Synthesis and Mechanism of Hypoglycemic Activity of Benzothiazole Derivatives". Journal of Medicinal Chemistry. 56 (13): 5335- ...
https://en.wikipedia.org/wiki/Arie_Lev_Gruzman
2-Aminothiophenol2-Aminothiophenol
It is a precursor to benzothiazoles, some of which are bioactive or are dyes. Isomers of aminothiophenols include 3- ...
https://en.wikipedia.org/wiki/2-Aminothiophenol
Sulfur dyeSulfur dye
These dyes are proposed to consist of polymers with benzothiazole subunits. Members of the sulfur bake dyes class are Sulfur ...
https://en.wikipedia.org/wiki/Sulfur_dye
CefroxadineCefroxadine
This undergoes fragmentation when treated with benzothiazole-2-thiol to give 2. Ozonolysis (reductive work-up) cleaves the ...
https://en.wikipedia.org/wiki/Cefroxadine
Biological pigmentBiological pigment
The compounds benzothiazole and tetrahydroisoquinoline ring systems act as UV-absorbing compounds. The only light source in the ...
https://en.wikipedia.org/wiki/Biological_pigment
Alcian yellowAlcian yellow
Its structure consists of a largely conjugated array of benzene, benzothiazole and isothiouronium units. Alcian yellow is used ...
https://en.wikipedia.org/wiki/Alcian_yellow
2-sec-Butyl-4,5-dihydrothiazole2-sec-Butyl-4,5-dihydrothiazole
... nitrile and the formation of thiazolines and benzothiazoles". Tetrahedron. 40 (11): 2141. doi:10.1016/S0040-4020(01)88457-X. ...
https://en.wikipedia.org/wiki/2-sec-Butyl-4,5-dihydrothiazole
Decarboxylative cross-couplingDecarboxylative cross-coupling
... benzothiazoles, and benzoxazoles. The position of the nitrogen atom in the '2' position relative to the linkage is found to be ...
https://en.wikipedia.org/wiki/Decarboxylative_cross-coupling
Moving bed biofilm reactorMoving bed biofilm reactor
"Hybrid Moving Bed Biofilm Reactor for the biodegradation of benzotriazoles and hydroxy-benzothiazole in wastewater". Journal of ... "Hybrid Moving Bed Biofilm Reactor for the biodegradation of benzotriazoles and hydroxy-benzothiazole in wastewater" (PDF). ...
https://en.wikipedia.org/wiki/Moving_bed_biofilm_reactor
ImidazothiazoleImidazothiazole
... benzothiazole". Journal of Pharmacy Research. 7 (1): 39-46. doi:10.1016/j.jopr.2013.01.002. ISSN 0974-6943. Amarouch, Hamid; ...
https://en.wikipedia.org/wiki/Imidazothiazole
BenzothiazineBenzothiazine
Phenothiazine has an additional benzene ring Benzothiazole is another heterocycle containing nitrogen and sulfur 1. Sulfostyril ...
https://en.wikipedia.org/wiki/Benzothiazine
Antonio Luiz BragaAntonio Luiz Braga
A Robust and Magnetically Recoverable Catalyst for Direct C-H Bond Selenylation and Sulfenylation of Benzothiazoles". ...
https://en.wikipedia.org/wiki/Antonio_Luiz_Braga
MercaptobenzothiazoleMercaptobenzothiazole
Treatment with Raney nickel results in monodesulfurization, giving benzothiazole: C6H4(NH)SC=S + H2 → C6H4(N)SCH + H2S The ... synthetic advances were reported in the 1920s that included demonstration that phenyldithiocarbamates pyrolyze to benzothiazole ...
https://en.wikipedia.org/wiki/Mercaptobenzothiazole
ThioflavinThioflavin
... T (Basic Yellow 1, Methylene yellow, CI 49005, or ThT) is a benzothiazole salt obtained by the methylation of ... Thioflavin T molecule consists of a benzylamine and a benzothiazole ring connected through a carbon-carbon bond. These two ...
https://en.wikipedia.org/wiki/Thioflavin
Melatonin receptor agonistMelatonin receptor agonist
Therefore it is possible to replace it with other aromatic ring systems (naphtalene, benzofurane, benzothiazole, indane, ...
https://en.wikipedia.org/wiki/Melatonin_receptor_agonist
Firefly luciferaseFirefly luciferase
Another mechanism proposes that twisting the angle between benzothiazole and thiazole rings in oxyluciferin determines the ...
https://en.wikipedia.org/wiki/Firefly_luciferase
Cysteinyl-leukotriene type 1 receptor antagonistsCysteinyl-leukotriene type 1 receptor antagonists
Replacement of the quinoline by benzothiazole, dichlorothienopyridines or alkyl-substituted thiazoles is possible but none of ...
https://en.wikipedia.org/wiki/Cysteinyl-leukotriene_type_1_receptor_antagonists
TriclosanTriclosan
"Contribution of primary and secondary treatment on the removal of benzothiazoles, benzotriazoles, endocrine disruptors, ...
https://en.wikipedia.org/wiki/Triclosan
FostedilFostedil
... constructs the benzothiazole ring. Bromination of this compound with N-bromosuccinimide produces bromomethyl intermediate. The ...
https://en.wikipedia.org/wiki/Fostedil
CyanineCyanine
... benzothiazole, etc. Cyanines were first synthesized over a century ago. They were originally used, and still are, to increase ...
https://en.wikipedia.org/wiki/Cyanine
Old person smellOld person smell
Another study failed to detect 2-nonenal at all, but found significantly increased concentrations of benzothiazole, ...
https://en.wikipedia.org/wiki/Old_person_smell
DexpramipexoleDexpramipexole
KNS-760704 [(6R)-4,5,6,7-tetrahydro-N6-propyl-2, 6-benzothiazole-diamine dihydrochloride monohydrate] for the Treatment of ...
https://en.wikipedia.org/wiki/Dexpramipexole
benzothiazole (CHEBI:45993)benzothiazole (CHEBI:45993)
... has role xenobiotic (CHEBI:35703) benzothiazole (CHEBI:45993) is a benzothiazoles (CHEBI:37947) ... benzothiazole (CHEBI:45993) has role environmental contaminant (CHEBI:78298) benzothiazole (CHEBI:45993) has role plant ... 2-methylthio-1,3-benzothiazole (CHEBI:1217) has parent hydride benzothiazole (CHEBI:45993). 2-hydroxybenzothiazole (CHEBI: ... CHEBI:45993 - benzothiazole. Main. ChEBI Ontology. Automatic Xrefs. Reactions. Pathways. Models. .gridLayoutCellStructure { min ...
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=45993
Biological Aspects of Emerging Benzothiazoles: A Short ReviewBiological Aspects of Emerging Benzothiazoles: A Short Review
Benzothiazole and benzoxazole derivatives," Journal of the American Chemical Society, vol. 75, no. 3, pp. 712-714, 1953. View ... C. Sheng, J. Zhu, W. Zhang et al., "3D-QSAR and molecular docking studies on benzothiazole derivatives as Candida albicans N- ... A. Rana, N. Siddiqui, S. A. Khan, S. E. Haque, and M. A. Bhat, "N-{[(6-Substituted-1,3-benzothiazole-2-yl)amino]carbonothioyl}- ... A. Ammazzalorso, A. Giancristofaro, A. DAngelo et al., "Benzothiazole-based N-(phenylsulfonyl)amides as a novel family of PPAR ...
https://www.hindawi.com/journals/jchem/2013/345198/ref/
3PO1: Thrombin In Complex With Benzothiazole Guanidine3PO1: Thrombin In Complex With Benzothiazole Guanidine
THROMBIN HEAVY CHAINTHROMBIN LIGHT CHAINTHROMBIN PEPTIDEAcetate IonEthyl [(2z)-2-(Carbamimidoylimino)-6-Hydroxy-1,3-Benzothiazol-3(2h)-Yl]acetateSodium Ion
https://www.ncbi.nlm.nih.gov/Structure/pdb/3PO1
Benzothiazole - WikipediaBenzothiazole - Wikipedia
The Benzothiazole Alkaloids" Australian Journal of Chemistry 62(7) 639-647.doi:10.1071/CH09126 "Benzothiazole". The Good Scents ... Firefly luciferin can be considered a derivative of benzothiazole. Benzothiazoles consist of a 5-membered 1,3-thiazole ring ... Benzothiazoles are prepared by treatment of 2-mercaptoaniline with acid chlorides: C6H4(NH2)SH + RC(O)Cl → C6H4(NH)SCR + HCl + ... Benzothiazole is an aromatic heterocyclic compound with the chemical formula C 7H 5NS. It is colorless, slightly viscous liquid ...
https://en.wikipedia.org/wiki/Benzothiazole
2-(Hydroxyazo)benzothiazole, sodium salt2-(Hydroxyazo)benzothiazole, sodium salt
Benzothiazole, 5-chloro-2-methylBenzothiazole, 5-chloro-2-methyl
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
https://webbook.nist.gov/cgi/cbook.cgi?ID=1006-99-1&
2-(Thiocyanomethylthio)benzothiazole 170082-(Thiocyanomethylthio)benzothiazole 17008
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. ...
https://ntp.niehs.nih.gov/testing/status/agents/ts-17008.html
Federal Register :: 2-(Thiocyanomethylthio)benzothiazole Risk Assessment; Notice of AvailabilityFederal Register :: 2-(Thiocyanomethylthio)benzothiazole Risk Assessment; Notice of Availability
... benzothiazole (TCMTB), and opens a public comment period on these documents. The public also is encouraged to suggest risk ... 2-(Thiocyanomethylthio)benzothiazole Risk Assessment; Notice of Availability. A Notice by the Environmental Protection Agency ... benzothiazole (TCMTB), and opens a public comment period on these documents. The public also is encouraged to suggest risk ...
https://www.federalregister.gov/documents/2006/04/26/E6-6300/2-thiocyanomethylthiobenzothiazole-risk-assessment-notice-of-availability
2-(morpholinothio)benzothiazole - Registration Dossier - ECHA2-(morpholinothio)benzothiazole - Registration Dossier - ECHA
Benzothiazole-2-thiole (MBT) and benzothoazole (BT) as hydrolysis products are considered here to support the assessment of MBS ...
https://echa.europa.eu/lv/registration-dossier/-/registered-dossier/11022/6/2/8
Benzothiazole-2-thiol - Substance Information - ECHABenzothiazole-2-thiol - Substance Information - ECHA
Benzothiazole-2-thiol. Translated names 18 CAS names 1 IUPAC names 9 Trade names 2 Other identifiers 9 ...
https://echa.europa.eu/substance-information/-/substanceinfo/100.005.216
Benzothiazole-2-thiol - Registered substances - ECHABenzothiazole-2-thiol - Registered substances - ECHA
Benzothiazole-2-thiol 205-736-8 149-30-4 null Full Joint 1 000 - 10 000 tonnes per annum 24-05-2020 View substance registered ... Benzothiazole-2-thiol 205-736-8 149-30-4 null Intermediate Individual Intermediate Use Only 02-04-2020 View substance ...
https://www.echa.europa.eu/web/guest/information-on-chemicals/registered-substances/-/disreg/substance/100.005.216
Biological Important Ni(II) Ternary Complexes Derived from 2-Substituted Benzothiazoles and Amino AcidsBiological Important Ni(II) Ternary Complexes Derived from 2-Substituted Benzothiazoles and Amino Acids
... benzothiazole (APBT) and L-L´ = 2-(2´-hydroxyphenyl)benzothiazole (HPBT), 2-(2´-mercaptophenyl)benzothiazole (MPBT) have been ... Biological Important Ni(II) Ternary Complexes Derived from 2-Substituted Benzothiazoles and Amino Acids. Narendra Pal, Mahesh ...
https://www.hindawi.com/journals/jchem/2011/612847/abs/
Provisional Peer-Reviewed Toxicity Values for Benzothiazole | Risk Assessment Portal | US EPAProvisional Peer-Reviewed Toxicity Values for Benzothiazole | Risk Assessment Portal | US EPA
Provisional Peer-Reviewed Toxicity Values for Benzothiazole. U.S. Environmental Protection Agency, Washington, DC, EPA/690/R-04 ... Provisional Peer-Reviewed Toxicity Values for Benzothiazole (PDF). (NA pp, 240 KB, about PDF) ...
https://cfpub.epa.gov/ncea/risk/recordisplay.cfm?deid=338837
2-(thiocyanomethylthio)benzothiazole2-(thiocyanomethylthio)benzothiazole
... benzothiazole , including approvals, environmental fate, eco-toxicity and human health issues ... 2-(thiocyanomethylthio)benzothiazole Last updated: 06/12/2019 (Also known as: TCMTB; benthiazole; alentisan; KVK 733059; TCMB) ...
http://sitem.herts.ac.uk/aeru/iupac/Reports/1573.htm
CiteSeerX - SYNTHESIS, CHARACTERISATION AND ANTI-INFLAMMATORY ACTIVITY OF SOME 2-AMINO BENZOTHIAZOLE DERIVATIVESCiteSeerX - SYNTHESIS, CHARACTERISATION AND ANTI-INFLAMMATORY ACTIVITY OF SOME 2-AMINO BENZOTHIAZOLE DERIVATIVES
Among the compounds tested three compounds Bt2 (5-chloro-1,3-benzothiazole-2-amine), Bt (6-methoxy-1,3-benzothiazole-2-amine) ... Key Words: Anti-inflammatory, bromine water, hind paw edema, benzothiazoles ... and Bt7 (6-methoxy-1,3-benzothiazole-2-amine)were the most active compounds in these series when compared with diclofenac ... methoxy substitution at 4 and 6-position in benzothiazole ring system showed better anti-inflammatory activity. ...
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.608.7244
3-Amino-2,1-benzothiazole-5-sulfonic acid | C7H6N2O3S2 - PubChem3-Amino-2,1-benzothiazole-5-sulfonic acid | C7H6N2O3S2 - PubChem
1-benzothiazole-5-sulfonic acid , C7H6N2O3S2 , CID 104612 - structure, chemical names, physical and chemical properties, ...
https://pubchem.ncbi.nlm.nih.gov/compound/104612
Cas 21564-17-0,2-(Thiocyanatomethylthio)benzothiazole | lookchemCas 21564-17-0,2-(Thiocyanatomethylthio)benzothiazole | lookchem
We also Provide Trading Suppliers & Manufacture for 21564-17-0 2-(Thiocyanatomethylthio)benzothiazole. ... 2-(Thiocyanatomethylmercapto)-benzothiazole. Cas No: 21564-17-0. No Data. No Data. No Data. Chemwill Asia Co., Ltd.. Contact ... 2-(Thiocyanatomethylthio)benzothiazole. Cas No: 21564-17-0. USD $ 3.0-3.0 / Kilogram. 1 Kilogram. 1-100 Metric Ton/Month. ... 2-(Thiocyanatomethylthio)benzothiazole 21564-17-0. Cas No: 21564-17-0. No Data. 1 Metric Ton. 10 Metric Ton/Month. Henan Tianfu ...
https://www.lookchem.com/casno21564-17-0.html
Synthesis and anti-angiogenic activity of benzothiazole, benzimidazole containing phthalimide derivatives. | Sigma-AldrichSynthesis and anti-angiogenic activity of benzothiazole, benzimidazole containing phthalimide derivatives. | Sigma-Aldrich
Benzothiazole and benzimidazole containing phthalimide derivatives (NK037, NK041, NK042, NK0139A and NK0148) have been ... Synthesis and anti-angiogenic activity of benzothiazole, benzimidazole containing phthalimide derivatives.. [Shunmugam ...
https://www.sigmaaldrich.com/catalog/papers/23182087
2,1-benzothiazole-3-sulfonyl chloride | CAS No. 128852-03-9 | Sigma-Aldrich2,1-benzothiazole-3-sulfonyl chloride | CAS No. 128852-03-9 | Sigma-Aldrich
1-benzothiazole-3-sulfonyl chloride; CAS Number: 128852-03-9; find Enamine-ENAH5802F48E MSDS, related peer-reviewed papers, ...
https://www.sigmaaldrich.com/catalog/buildingblock/product/enamine/enah5802f48e?lang=en®ion=US
Molecules | Free Full-Text | Design and Synthesis of New Benzothiazole Compounds as Selective hMAO-B InhibitorsMolecules | Free Full-Text | Design and Synthesis of New Benzothiazole Compounds as Selective hMAO-B Inhibitors
In the current work a new class of novel benzothiazole-hydrazone derivatives was designed and synthesized as hMAO-B inhibitors ... Keywords: benzothiazole; hydrazone; MAO enzyme inhibition; docking study; cytotoxicity benzothiazole; hydrazone; MAO enzyme ... In the current work a new class of novel benzothiazole-hydrazone derivatives was designed and synthesized as hMAO-B inhibitors ... Design and Synthesis of New Benzothiazole Compounds as Selective hMAO-B Inhibitors. Sinem Ilgın 1. ...
http://www.mdpi.com/1420-3049/22/12/2187
Molecules | Free Full-Text | Synthesis and in vitro Evaluation of New Benzothiazole Derivatives as Schistosomicidal AgentsMolecules | Free Full-Text | Synthesis and in vitro Evaluation of New Benzothiazole Derivatives as Schistosomicidal Agents
Keywords: Benzothiazole; dithiocarbamate; thiadiazole; thiosemicarbazones; schistosomicidal agents. Benzothiazole; ... Synthesis and in vitro Evaluation of New Benzothiazole Derivatives as Schistosomicidal Agents. Mona A Mahran 1,* , Samia ... Mahran, M.A.; William, S.; Ramzy, F.; Sembel, A.M. Synthesis and in vitro Evaluation of New Benzothiazole Derivatives as ... "Synthesis and in vitro Evaluation of New Benzothiazole Derivatives as Schistosomicidal Agents." Molecules 12, no. 3: 622-633. ...
http://www.mdpi.com/1420-3049/12/3/622
Benzotriazoles and benzothiazoles in human urine from several countries: a perspective on occurrence, biotransformation, and...Benzotriazoles and benzothiazoles in human urine from several countries: a perspective on occurrence, biotransformation, and...
... and benzothiazole (BTH) derivatives are high-production-volume chemicals that are mainly used as corrosion inhibitors, and are ... benzothiazole, 2-morpholin-4-yl-benzothiazole, 2-hydroxy-benzothiazole, 2-methylthio-benzothiazole, 2-amino-benzothiazole, and ... 2-hydroxy-benzothiazole; 2-methylthio-benzothiazole; 2-morpholin-4-yl-benzothiazole; 2-thiocyanomethylthio-benzothiazole; 4-Me- ... Benzotriazole (BTR) and benzothiazole (BTH) derivatives are high-production-volume chemicals that are mainly used as corrosion ...
https://pubmed.ncbi.nlm.nih.gov/23850588/?dopt=Abstract
Visible light photoredox catalysis: conversion of a mixture of thiophenols and nitriles into 2-substituted benzothiazoles via...Visible light photoredox catalysis: conversion of a mixture of thiophenols and nitriles into 2-substituted benzothiazoles via...
... visible-light-mediated method for the construction of 2-substituted benzothiazoles from easily available thiophenols (2.0 equiv ... To the best of our knowledge, this is the first example of the synthesis of 2-substituted benzothiazoles through sequential C-S ... Visible light photoredox catalysis: conversion of a mixture of thiophenols and nitriles into 2-substituted benzothiazoles via ... Visible light photoredox catalysis: conversion of a mixture of thiophenols and nitriles into 2-substituted benzothiazoles via ...
http://pubs.rsc.org/en/content/articlelanding/2018/qo/c8qo00219c/unauth
Synthesis, Molecular Docking, DNA Binding and Anticancer Studies of Transition Metal Complex of N-[Phenylmethylidene]-1,3...Synthesis, Molecular Docking, DNA Binding and Anticancer Studies of Transition Metal Complex of N'-[Phenylmethylidene]-1,3...
3-benzothiazole-2-carbohydrazone (PMBC) and its Cu(II), Ni(II), Co(II) and Zn(II) metal complexes. The quantum chemical ... 3-Benzothiazole-2-Carbohydrazone. Proceedings of International Conference on Drug Discovery (ICDD) 2020 ... 3-Benzothiazole-2-Carbohydrazone (February 1, 2020). Proceedings of International Conference on Drug Discovery (ICDD) 2020, ...
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3529839
Cas 99972-98-2,Benzothiazole, 4-methyl-2-(2-propynylthio)- (6CI) | lookchemCas 99972-98-2,Benzothiazole, 4-methyl-2-(2-propynylthio)- (6CI) | lookchem
We also Provide Trading Suppliers & Manufacture for 99972-98-2 Benzothiazole, 4-methyl-2-(2-propynylthio)- (6CI). ... CAS DataBase Reference: Benzothiazole, 4-methyl-2-(2-propynylthio)- (6CI)(CAS DataBase Reference) ... EPA Substance Registry System: Benzothiazole, 4-methyl-2-(2-propynylthio)- (6CI)(99972-98-2) ... NIST Chemistry Reference: Benzothiazole, 4-methyl-2-(2-propynylthio)- (6CI)(99972-98-2) ...
https://www.lookchem.com/casno99972-98-2.html
Benzothiazole | 95-16-9Benzothiazole | 95-16-9
You can also browse global suppliers,vendor,prices,Price,manufacturers of Benzothiazole(95-16-9). At last,Benzothiazole(95-16-9 ... Visit ChemicalBook To find more Benzothiazole(95-16-9) information like chemical properties,Structure,melting point,boiling ... Benzothiazole Spectrum. Benzothiazole(95-16-9) IR1Benzothiazole(95-16-9) IR2Benzothiazole(95-16-9) MSBenzothiazole(95-16-9) 13C ... Benzothiazole 96%. 95-16-9. 100g. $34. 2018-11-13. Buy. TCI Chemical B0092. Benzothiazole >96.0%(GC). 95-16-9. 25mL. $15. 2018- ...
https://www.chemicalbook.com/ChemicalProductProperty_EN_CB1720657.htm
Anticonvulsant and Neurological Profile of Benzothiazoles: A Mini-Review | Bentham ScienceAnticonvulsant and Neurological Profile of Benzothiazoles: A Mini-Review | Bentham Science
Benzothiazole molecule has a heterocyclic structure, basic in nature with wide variety of active sites. As a small molecule, it ... Benzothiazole molecule has a heterocyclic structure, basic in nature with wide variety of active sites. As a small molecule, it ... Benzothiazole derivatives were found to exhibit efficacy against some very serious diseases like cancer, neurodegeneration, ... Benzothiazole derivatives were found to exhibit efficacy against some very serious diseases like cancer, neurodegeneration, ...
https://www.eurekaselect.com/127540/article?tracking-code=4
Benzothiazole derivatives, processes for their preparation and pharmaceutical compositions containing these compounds -...Benzothiazole derivatives, processes for their preparation and pharmaceutical compositions containing these compounds -...
Benzothiazole derivatives corresponding to the general formula I ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 ... Benzothiazole derivatives corresponding to the general formula I ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 ... a) a benzothiazole derivative corresponding to the general formula II ##STR24## wherein R.sup.1 to R.sup.5 have the meanings ... b) a benzothiazole derivative corresponding to the general formula III ##STR25## wherein R.sup.1 to R.sup.4 have the meanings ...
http://www.patentgenius.com/patent/4732986.html
Benzothiazole, 4-nitro- (6CI,7CI,8CI,9CI) (CAS 2942-08-7) Market Research Report 2018Benzothiazole, 4-nitro- (6CI,7CI,8CI,9CI) (CAS 2942-08-7) Market Research Report 2018
The report generally describes benzothiazole, 4-nitro- (6ci,7ci,8ci,9ci), examines its uses, production methods, patents. ... Benzothiazole, 4-nitro- (6ci,7ci,8ci,9ci) prices in other regions. 7. BENZOTHIAZOLE, 4-NITRO- (6CI,7CI,8CI,9CI) END-USE SECTOR ... Benzothiazole, 4-nitro- (6ci,7ci,8ci,9ci) market forecast. 6. BENZOTHIAZOLE, 4-NITRO- (6CI,7CI,8CI,9CI) MARKET PRICES. 6.1. ... Benzothiazole, 4-nitro- (6ci,7ci,8ci,9ci) prices in Europe. 6.2. Benzothiazole, 4-nitro- (6ci,7ci,8ci,9ci) prices in Asia 6.3. ...
https://marketpublishers.com/report/industry/chemicals_petrochemicals/benzothiazole_4-nitro-_6ci_7ci_8ci_9ci_2942-08-7_market_research_report.html
6-Methoxy-1,3-benzothiazole-2-thiol (CAS 2182-73-2) Market Research Report 20186-Methoxy-1,3-benzothiazole-2-thiol (CAS 2182-73-2) Market Research Report 2018
3-benzothiazole-2-thiol (CAS 2182-73-2) Market Research Report 2018 aims at providing comprehensive data on 6-methoxy-1,3- ... 6-methoxy-1,3-benzothiazole-2-thiol prices in other regions. 7. 6-METHOXY-1,3-BENZOTHIAZOLE-2-THIOL END-USE SECTOR 7.1. 6- ... 6-methoxy-1,3-benzothiazole-2-thiol market forecast. 6. 6-METHOXY-1,3-BENZOTHIAZOLE-2-THIOL MARKET PRICES. 6.1. 6-methoxy-1,3- ... 6-methoxy-1,3-benzothiazole-2-thiol prices in Asia 6.3. 6-methoxy-1,3-benzothiazole-2-thiol prices in North America. 6.4. ...
https://marketpublishers.com/report/industry/chemicals_petrochemicals/2_3h_-benzothiazolethione_6-methoxy-_9ci_2182-73-2_market_research_report.html
SynthesisABSTRACTCompoundsDerivativeSulfenamideSulfonamideInhibitorsBenzimidazole and benzothiazoleSelectiveSchiff BasesCyclizationChemistryHeterocyclic compoundAmino AcidsPhthalimidePhenylAcceleratorsMoleculeComplexesCompoundAromaticCorrosionSulfurSuppliersBenzeneAnalgesicCondensation
Synthesis22
  • Synthesis, structure-activity relationships and preliminary antitumor evaluation of benzothiazole-2-thiol derivatives as novel apoptosis inducers," Bioorganic and Medicinal Chemistry Letters , vol. 21, no. 4, pp. 1097-1101, 2011. (hindawi.com)
  • Synthesis, X-ray crystallographic analysis, and antitumor activity of N -(benzothiazole-2-yl)-1-(fluorophenyl)- O , O -dialkyl- α -aminophosphonates," Bioorganic and Medicinal Chemistry Letters , vol. 16, no. 6, pp. 1537-1543, 2006. (hindawi.com)
  • Synthesis of benzothiazole derivatives and their biological evaluation as anticancer agents," Medicinal Chemistry Research , vol. 21, pp. 2644-2651, 2012. (hindawi.com)
  • Synthesis and anti-cancer activity of benzothiazole containing phthalimide on human carcinoma cell lines," Bioorganic and Medicinal Chemistry , vol. 16, no. 7, pp. 3626-3631, 2008. (hindawi.com)
  • Synthesis of novel 2-[4-(4-substitutedbenzamido/phenylacetamido)phenyl]benzothiazoles as antimicrobial agents," Medicinal Chemistry Research , vol. 21, no. 11, pp. 3818-3825, 2012. (hindawi.com)
  • Synthesis and antimicrobial activity of novel 2-substituted benzimidazole, benzoxazole and benzothiazole derivatives," Arabian Journal of Chemistry , 2012. (hindawi.com)
  • S. Gilani, K. Nagarajan, S. P. Dixit, M. Taleuzzaman, and S. A. Khan, "Benzothiazole incorporated thiazolidin-4-ones and azetidin-2-ones derivatives: synthesis and in vitro antimicrobial evaluation," Arabian Journal of Medicinal Chemistry , 2012. (hindawi.com)
  • Synthesis and anti-angiogenic activity of benzothiazole, benzimidazole containing phthalimide derivatives. (sigmaaldrich.com)
  • Sembel, A.M. Synthesis and in vitro Evaluation of New Benzothiazole Derivatives as Schistosomicidal Agents. (mdpi.com)
  • Mahran MA, William S, Ramzy F, Sembel AM. Synthesis and in vitro Evaluation of New Benzothiazole Derivatives as Schistosomicidal Agents. (mdpi.com)
  • To the best of our knowledge, this is the first example of the synthesis of 2-substituted benzothiazoles through sequential C-S and C-N bond formation reactions under photoredox catalysis. (rsc.org)
  • In the present work we report design, synthesis, molecular docking, cytotoxicity and DNA binding studies of N'-[Phenylmethylidene]-1,3-benzothiazole-2-carbohydrazone (PMBC) and its Cu(II), Ni(II), Co(II) and Zn(II) metal complexes. (ssrn.com)
  • Synthesis and cyclization of benzothiazole. (chemicalbook.com)
  • An easy synthetic protocol for the synthesis of biologically active benzimidazole, benzothiazole and benzoxazole derivatives has been demonstrated using a hybrid crystal NH 3 (CH 2 ) 4 NH 3 SiF 6 as a mild and efficient heterogeneous catalyst. (figshare.com)
  • Results: We report here a very simple, novel, efficient, and catalyst-free method for the synthesis of benzimidazole and benzothiazole in good to excellent yields from the treatment of 1,2-phenylenediamine and 2-aminothiophenol with various 5-arylidenepyrimidine-2,4,6(1H,3H,5H)-trione, respectively. (eurekaselect.com)
  • Conclusion: This method appears to be general for the synthesis of benzimidazoles and benzothiazoles using 5-arylidenepyrimidine-2,4,6-(1H,3H,5H)-trione derivatives containing various aromatic and heteroaromatic aldehydes such as furfural and thiophene-2-carbaldehyde with electron-withdrawing and electron-releasing groups. (eurekaselect.com)
  • Guanidinyl benzothiazole derivatives: Synthesis and structure activity relationship studies of a. (deepdyve.com)
  • Mahmood, Z., Ahmad, A. Synthesis of Some Heterocyclic Compounds Derived From 2-Amino Benzothiazole. (iraqjournals.com)
  • Synthesis, characterization and cytotoxic activities of ten benzothiazole-piperazine derivatives were reported. (bilkent.edu.tr)
  • Zhi-Bing Dong describes an iodobenzene-promoted palladium-catalyzed synthesis of benzothiazoles via intramolecular coupling. (thieme.de)
  • Here, we report the discovery and synthesis of a series of novel benzothiazole derivatives and their inhibitory activities against 11beta-HSD1 from human hepatic microsomes measured using a radioimmunoassay (RIA) method. (ox.ac.uk)
  • IMSEAR at SEARO: Synthesis and in vivo Anti-inflammatory and Analgesic activities of Oxadiazoles clubbed with Benzothiazole nucleus. (who.int)
ABSTRACT1
  • ABSTRACT: A series of some novel 2-amino benzothiazole derivatives were synthesized and evaluated for anti-inflammatory activity. (psu.edu)
Compounds8
  • Among the compounds tested three compounds Bt2 (5-chloro-1,3-benzothiazole-2-amine), Bt (6-methoxy-1,3-benzothiazole-2-amine) and Bt7 (6-methoxy-1,3-benzothiazole-2-amine)were the most active compounds in these series when compared with diclofenac sodium. (psu.edu)
  • Benzothiazole and its derivative are recognized as the most important heterocyclic compounds. (chemicalbook.com)
  • This invention relates to new benzothiazole derivatives, a process fortheir preparation, their use as pharmaceutical preparations, in particular their use as lipoxygenase inhibitors and cyclooxygenase inhibitors, pharmaceutical preparations containing these compounds, and their preparation. (patentgenius.com)
  • Control of neurodegenerative diseases with benzothiazole-benzamide derivatives CSIC has developed a group of heterocyclic compounds derived from a privileged structural nucleus with the capacity to inhibit the LRRK2 enzyme. (innoget.com)
  • Background: Benzimidazole and benzothiazole subunits exist in many biologically active molecules, natural products, and synthetic compounds. (eurekaselect.com)
  • Also from the reaction of (2-amino benzothiazole) with phthalic anhydride or malic anhydride attended compounds (8) and (9) ,respectively. (iraqjournals.com)
  • Compared with known corrosion inhibitors based on benzothiazole derivatives, the compounds are distinguished by a lower water absorption, by chemical inertness and by a high stability to heat. (justia.com)
  • Benzothiazole are important group of compounds reported to have various biological activities and hence the present study was undertaken in order to synthesize same new compounds built upon this nucleus with the hope to enhance the biological properties of newly designed compounds. (derpharmachemica.com)
Derivative5
  • Firefly luciferin can be considered a derivative of benzothiazole. (wikipedia.org)
  • A benzothiazole derivative is suggested as a dye for arsenic detection. (wikipedia.org)
  • The broad spectrum of pharmacological activity in individual benzothiazole derivative enables it to serve as unique and valuable scaffolds for experimental drug design. (chemicalbook.com)
  • Benzothiazole derivative (BD): [N-(3-(benzothiazol- 2-yl) phenyl)-1H-pyrazole-3-carboxamide] was tested for excretion of total sterols of high-fat diet fed C57BL/6J mice in view of lipid metabolism. (atlantis-press.com)
  • Docking studies with the benzothiazole derivative 1 into the crystal structure of human 11beta-HSD1 revealed how the molecule may interact with the enzyme and cofactor. (ox.ac.uk)
Sulfenamide9
  • N-Cyclohexyl-2-benzothiazole sulfenamide ACGIH TLV None Listed OSHA PEL None Listed Respiratory Appropriate respiratory protection shall be worn when applied engineering controls are not adequate to protect against inhalation exposure. (schilderoord.nl)
  • 3/10/2007 · N-cyclohexyl-2-benzothiazole sulfenamide Results in the Carcinogenic Potency Database N-Cyclohexyl-2-benzothiazole sulfenamide (CAS 95-33-0) SMILES, InChI and Structure are below. (promoworx.co.za)
  • The n-cyclohexyl -2- benzothiazole Sulfenamide market is disintegrating and is highly competitive owing to the presence of major players and regional players. (promoworx.co.za)
  • Accelerator CBS(CZ),N-Cyclohexyl-2-benzothiazole sulfenamide---Rongcheng Chemical General Factory Co., Ltd. (promoworx.co.za)
  • China Accelerator CBS for Synthetic Rubber CAS 95-33-0 N-Cyclohexyl-2-Benzothiazole Sulfenamide, Find details about China Accelerator CBS, Zinc 2-Mercaptobenzothiazole from Accelerator CBS for Synthetic Rubber CAS 95-33-0 N-Cyclohexyl-2-Benzothiazole Sulfenamide Hainan Zhongxin Chemical Co., Ltd. (holebiwest.be)
  • China Accelerator CBS for Synthetic Rubber CAS 95-33-0 N. Accelerator CBS, Zinc 2-Mercaptobenzothiazole, CAS No.: 155-04-4 manufacturer / supplier in China, offering Accelerator CBS for Synthetic Rubber CAS 95-33-0 N-Cyclohexyl-2-Benzothiazole Sulfenamide, Citrus Bioflavonoids Extract Hesperidin, Ethyl Vitamin C Ascorbic Acid CAS: 86404-04-8 and so on. (holebiwest.be)
  • Rubber Accelerator Dcbs Dz,Rubber Accelerator Dcbs Dz,Chemical Auxiliary Agent,4979-32-2,N.n-dicyclohexyl-2-benzothiazole Sulfenamide from Plastic Auxiliary Agents Supplier or Manufacturer-Dalian Richon Chem Co., Ltd. (holebiwest.be)
  • DCBS N-Cyclohexyl Benzothiazole Sulfenamide N,N- DICYCLOHEX YL-2- BENZOTHIAZ OLESULFENA MIDE 4979-32- 2 Vulkacit DZ Santocure DCBS Durax Accelerator DCBS Accicure DCS Akrochem PMC Chemicals Ltd 11. (holebiwest.be)
  • Dcbs, Dcbs (DZ), N N-Dicyclohexyl-2-Benzothiazole Sulfenamide manufacturer / supplier in China, offering Export Grade Rubber Accelerator Dcbs (DZ) CAS No.: 4979-32-2, White Powder 99.6% Feed Grade Ammonium Chloride, Citric Acid Anhydrous HS: 2918140000 and so on. (holebiwest.be)
Sulfonamide1
  • N-cyclohexyl-1,3-benzothiazole-2-sulfonamide State SOLID (MINERAL OIL MULL) Instrument Not specified, most likely a prism, grating, or hybrid spectrometer. (promoworx.co.za)
Inhibitors10
  • Benzothiazole-containing hydroxamic acids as histone deacetylase inhibitors and antitumor agents," Bioorganic and Medicinal Chemistry Letters , vol. 21, no. 24, pp. 7509-7512, 2011. (hindawi.com)
  • 3D-QSAR and molecular docking studies on benzothiazole derivatives as Candida albicans N -myristoyltransferase inhibitors," European Journal of Medicinal Chemistry , vol. 42, no. 4, pp. 477-486, 2007. (hindawi.com)
  • In the current work a new class of novel benzothiazole-hydrazone derivatives was designed and synthesized as h MAO-B inhibitors. (mdpi.com)
  • Benzotriazole (BTR) and benzothiazole (BTH) derivatives are high-production-volume chemicals that are mainly used as corrosion inhibitors, and are widely distributed in the environment. (nih.gov)
  • Evaluation of the benzothiazole aggregation inhibitors riluzole and PGL-135 as therapeutics for Huntington's disease. (semanticscholar.org)
  • The present invention relates to 2-amino-benzothiazole sulfonamides, their use as broadspectrum HIV protease inhibitors, processes for their preparation as well as pharmaceutical compositions and diagnostic kits comprising them. (allindianpatents.com)
  • The invention relates to phenolic derivatives of benzothiazole and to their use as corrosion inhibitors in organic materials, especially coating materials and lubricants. (justia.com)
  • Various derivatives of mercaptobenzothiazole have also already been suggested as corrosion inhibitors, for example the benzothiazole-2-ylthiocarboxylic acids and their salts which are described in EP-A 129,506. (justia.com)
  • It has now been found that certain benzothiazole derivatives containing hydrophobic groups can also be excellent corrosion inhibitors. (justia.com)
  • Benzothiazole derivatives as novel inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1. (ox.ac.uk)
Benzimidazole and benzothiazole2
  • New convenient conditions for benzimidazole and benzothiazole syntheses are described. (enamine.net)
  • Methods: 2-Substituted benzimidazole and benzothiazole derivatives have been synthesized by the condensation of 1,2-phenylenediamine or 2-aminobenzothiophenol with 5-arylidenepyrimidine-2,4,6-(1H,3H, 5H)-trione derivatives via cleavage of C-C double bond without using a catalyst in EtOH under reflux conditions. (eurekaselect.com)
Selective2
  • It is surprisingly found that the benzothiazole derivatives which may be used according to the invention have a powerful inhibitory action which in some cases is a highly selective action on the enzyme lipoxygenase at concentrations at whichcyclooxygenase is unaffected while some benzothiazole derivatives inhibit both enzymes, lipoxygenase and cyclooxygenase. (patentgenius.com)
  • Part 20:3′-Cyano and 3′-Alkynyl-substituted 2-(4′-Aminophenyl)benzothiazoles as new potent and selective analogues. (springer.com)
Schiff Bases1
  • Novel ruthenium(II/III) complexes of Schiff bases containing benzimidazole (bz) or benzothiazole (bs) moieties were isolated: the diamagnetic ruthenium complex, cis-[RuIICl2(bzpy)(PPh3)2] (1) was formed from the 1:1 M reaction between N-((pyridine-2-yl)methylene)-1H-benzimidazole (bzpy) and metal precursor, trans-[RuCl2(PPh3)3]. (edu.ng)
Cyclization1
  • In the present work 2-substituted benzothiazole (a) was prepared from p-tolnidine via cyclization reaction then N-2-benzothiazolyl thiourea was synthesized by reacting (a) with ammonium thiocyanate. (derpharmachemica.com)
Chemistry3
  • A comprehensive review in current developments of benzothiazole-based molecules in medicinal chemistry. (chemicalbook.com)
  • Jagbir Gagoria, Prabhakar Kumar Verma and Anurag Khatkar, "Anticonvulsant and Neurological Profile of Benzothiazoles: A Mini-Review", Central Nervous System Agents in Medicinal Chemistry (2015) 15: 11. (eurekaselect.com)
  • Belagali, S. 2016-01-29 00:00:00 Keywords Guanidinyl benzothiazole Antioxidant activity DPPH assay ABTS assay Antimicrobial Introduction One of the main aims of synthetic chemistry is the development of new antimicrobial therapeutic agents. (deepdyve.com)
Heterocyclic compound1
  • Benzothiazole is an aromatic heterocyclic compound with the chemical formula C 7H 5NS. (wikipedia.org)
Amino Acids1
  • The reaction, which is performed under mild conditions, can be used as a deprotection method for cleavage of benzothiazole-2-sulfonyl-protected amino acids. (ru.nl)
Phthalimide1
  • Benzothiazole and benzimidazole containing phthalimide derivatives (NK037, NK041, NK042, NK0139A and NK0148) have been synthesized and their anti-angiogenic activity was evaluated using ex vivo egg yolk angiogenesis model. (sigmaaldrich.com)
Phenyl1
  • In the SAR study, the phenyl ring substituted with chloro at 5 position, methoxy substitution at 4 and 6-position in benzothiazole ring system showed better anti-inflammatory activity. (psu.edu)
Accelerators1
  • Accelerators contain sulfur and nitrogen like derivatives of benzothiazole and thiocarbanilides. (holebiwest.be)
Molecule1
  • Benzothiazole molecule has a heterocyclic structure, basic in nature with wide variety of active sites. (eurekaselect.com)
Complexes2
  • Biological important ternary complexes of the type [NiCl(L-L) (A-A)(H 2 O)] and [Ni(L-L´)(A-A)(H 2 O) 2 ], where A-A = Glycine (Gly), Alanine (Ala), L-L = 2-(2´-aminophenyl)benzothiazole (APBT) and L-L´ = 2-(2´-hydroxyphenyl)benzothiazole (HPBT), 2-(2´-mercaptophenyl)benzothiazole (MPBT) have been synthesized. (hindawi.com)
  • Ir( III ) complexes that contain benzothiazole -based tridentate ligands were synthesized and their crystal structures and luminescent properties were examined. (rsc.org)
Compound2
  • Although the parent compound, benzothiazole is not widely used, many of its derivatives are found in commercial products or in nature. (wikipedia.org)
  • The N-(1,3-benzothiazol-2-yl)-2-chloro acetamide compound(1) was prepared from the reaction of the compound (2-amino benzothiazole) with chloroacetyl chloride. (iraqjournals.com)
Aromatic1
  • A set of benzimidazoles, 3 H -imidazo[4,5- b ]pyridines, purines, xanthines and benzothiazoles was readily prepared from (hetero)aromatic ortho -diamines or ortho -aminothiophenol and aldehydes using chlorotrimethylsilane in DMF as a promoter and water-acceptor agent, followed by oxidation with air oxygen. (enamine.net)
Corrosion1
  • Pulse radiolysis study of 2-Mercapto-benzothiazole-a corrosion inhibitor Mahal, H. (deepdyve.com)
Sulfur1
  • Benzothiazole-2-sulfonamides react with an excess of hydroxylamine in aqueous solutions to form 2-hydroxybenzothiazole, sulfur dioxide, and the corresponding amine. (ru.nl)
Suppliers4
  • benzothiazole, 4-nitro- (6ci,7ci,8ci,9ci) manufacturers and suppliers with contacts and product range are mentioned in the study. (marketpublishers.com)
  • It captures 6-methoxy-1,3-benzothiazole-2-thiol market trends, pays close attention to 6-methoxy-1,3-benzothiazole-2-thiol manufacturers and names suppliers. (marketpublishers.com)
  • 5 benzothiazole uses products are offered for sale by suppliers on Alibaba A wide variety of benzothiazole uses options are available to you, There are 5 suppliers who sells benzothiazole uses on Alibaba, mainly located in Asia. (holebiwest.be)
  • The top countries of suppliers are China, India, from which the percentage of benzothiazole uses supply is 60%, 40% respectively. (holebiwest.be)
Benzene2
  • Benzothiazoles consist of a 5-membered 1,3-thiazole ring fused to a benzene ring. (wikipedia.org)
  • Benzothiazoles are related to thiazoles, which lack the fused benzene ring. (wikipedia.org)
Analgesic1
  • Various benzothiazole-benzamides synthesized were evaluated for their analgesic and antidepressant activities. (chemicalbook.com)
Condensation1
  • A new benzothiazole linked nanoporous polymer, imine benzothiazole polymer (IBTP), was synthesized via a Schiff base condensation reaction. (elsevier.com)
3-Amino-2,1-benzothiazole-5-sulfonic acid | C7H6N2O3S2 - PubChem
3-Amino-2,1-benzothiazole-5-sulfonic acid | C7H6N2O3S2 - PubChem (pubchem.ncbi.nlm.nih.gov)
Benzothiazole (CHEBI:45993)
Benzothiazole (CHEBI:45993) (ebi.ac.uk)
Antitumor benzothiazoles. 26.(1) 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (GW 610, NSC 721648), a simple fluorinated 2...
Antitumor benzothiazoles. 26.(1) 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (GW 610, NSC 721648), a simple fluorinated 2... (sigmaaldrich.com)
Federal Register :: 2-(Thiocyanomethylthio)benzothiazole Risk Assessment; Notice of Availability
Federal Register :: 2-(Thiocyanomethylthio)benzothiazole Risk Assessment; Notice of Availability (federalregister.gov)
Heterocyclic Communications
Heterocyclic Communications (degruyter.com)
Benzothiazole, 5-chloro-2-methyl
Benzothiazole, 5-chloro-2-methyl (webbook.nist.gov)
2-(morpholinothio)benzothiazole - Registration Dossier - ECHA
2-(morpholinothio)benzothiazole - Registration Dossier - ECHA (echa.europa.eu)
Charles Laughton - The University of Nottingham
Charles Laughton - The University of Nottingham (nottingham.ac.uk)
Benzthiazol-Synthese mittels intramolekularer Kupplung - Thieme Chemistry - Georg Thieme Verlag KG
Benzthiazol-Synthese mittels intramolekularer Kupplung - Thieme Chemistry - Georg Thieme Verlag KG (thieme.de)
Fisher Scientific
Fisher Scientific (fishersci.com)
One-Pot Synthesis of 2′-Aminobenzothiazolo-Arylmethyl-2-Naphthols Catalyzed by NBS under Solvent-Free Conditions
One-Pot Synthesis of 2′-Aminobenzothiazolo-Arylmethyl-2-Naphthols Catalyzed by NBS under Solvent-Free Conditions (hindawi.com)
CiteSeerX - SYNTHESIS, CHARACTERISATION AND ANTI-INFLAMMATORY ACTIVITY OF SOME 2-AMINO BENZOTHIAZOLE DERIVATIVES
CiteSeerX - SYNTHESIS, CHARACTERISATION AND ANTI-INFLAMMATORY ACTIVITY OF SOME 2-AMINO BENZOTHIAZOLE DERIVATIVES (citeseerx.ist.psu.edu)
CFR - Code of Federal Regulations Title 21
CFR - Code of Federal Regulations Title 21 (accessdata.fda.gov)
Other Plastic Raw Materials - latest Other Plastic Raw Materials from Other Plastic Raw Materials suppliers in China
Other Plastic Raw Materials - latest Other Plastic Raw Materials from Other Plastic Raw Materials suppliers in China (xpandrally.com)
Molecules | Free Full-Text | Design and Synthesis of New Benzothiazole Compounds as Selective hMAO-B Inhibitors
Molecules | Free Full-Text | Design and Synthesis of New Benzothiazole Compounds as Selective hMAO-B Inhibitors (mdpi.com)
Foods | Free Full-Text | Chemical Compositions of the Volatile Oils and Antibacterial Screening of Solvent Extract from Downy...
Foods | Free Full-Text | Chemical Compositions of the Volatile Oils and Antibacterial Screening of Solvent Extract from Downy... (mdpi.com)
CAS Number Listing - Numbers Beginning With 9, NMAM 4thh | NIOSH | CDC
CAS Number Listing - Numbers Beginning With 9, NMAM 4thh | NIOSH | CDC (cdc.gov)
Synthesis and anti-angiogenic activity of benzothiazole, benzimidazole containing phthalimide derivatives. | Sigma-Aldrich
Synthesis and anti-angiogenic activity of benzothiazole, benzimidazole containing phthalimide derivatives. | Sigma-Aldrich (sigmaaldrich.com)
Anti-Cancer Agents in Medicinal Chemistry, Volume 17 - Number 13
Anti-Cancer Agents in Medicinal Chemistry, Volume 17 - Number 13 (benthamscience.com)