Benzothiazoles: Compounds with a benzene ring fused to a thiazole ring.ThiazolesCytochrome P-450 CYP1A1: A liver microsomal cytochrome P-450 monooxygenase capable of biotransforming xenobiotics such as polycyclic hydrocarbons and halogenated aromatic hydrocarbons into carcinogenic or mutagenic compounds. They have been found in mammals and fish. This enzyme, encoded by CYP1A1 gene, can be measured by using ethoxyresorufin as a substrate for the ethoxyresorufin O-deethylase activity.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Tegafur: Congener of FLUOROURACIL with comparable antineoplastic action. It has been suggested especially for the treatment of breast neoplasms.Aniline CompoundsMolecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Fraud: Exploitation through misrepresentation of the facts or concealment of the purposes of the exploiter.Medicare Assignment: Concept referring to the standardized fees for services rendered by health care providers, e.g., laboratories and physicians, and reimbursement for those services under Medicare Part B. It includes acceptance by the physician.Halogens: A family of nonmetallic, generally electronegative, elements that form group 17 (formerly group VIIa) of the periodic table.Hydrogen: The first chemical element in the periodic table. It has the atomic symbol H, atomic number 1, and atomic weight [1.00784; 1.00811]. It exists, under normal conditions, as a colorless, odorless, tasteless, diatomic gas. Hydrogen ions are PROTONS. Besides the common H1 isotope, hydrogen exists as the stable isotope DEUTERIUM and the unstable, radioactive isotope TRITIUM.Alkylation: The covalent bonding of an alkyl group to an organic compound. It can occur by a simple addition reaction or by substitution of another functional group.Marketing: Activity involved in transfer of goods from producer to consumer or in the exchange of services.Research Report: Detailed account or statement or formal record of data resulting from empirical inquiry.Foundations: Organizations established by endowments with provision for future maintenance.Cathode Ray Tube: A vacuum tube equipped with an electron emitting CATHODE and a fluorescent screen which emits visible light when excited by the cathode ray. Cathode ray tubes are used as imaging devises for TELEVISIONS; COMPUTER TERMINALS; TEXT TELECOMMUNICATION DEVICES; oscilloscopes; and other DATA DISPLAY devices.Quantum Dots: Nanometer sized fragments of semiconductor crystalline material which emit PHOTONS. The wavelength is based on the quantum confinement size of the dot. They can be embedded in MICROBEADS for high throughput ANALYTICAL CHEMISTRY TECHNIQUES.Semiconductors: Materials that have a limited and usually variable electrical conductivity. They are particularly useful for the production of solid-state electronic devices.Curing Lights, Dental: Light sources used to activate polymerization of light-cured DENTAL CEMENTS and DENTAL RESINS. Degree of cure and bond strength depends on exposure time, wavelength, and intensity of the curing light.Ligands: A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)Lasers, Semiconductor: Lasers with a semiconductor diode as the active medium. Diode lasers transform electric energy to light using the same principle as a light-emitting diode (LED), but with internal reflection capability, thus forming a resonator where a stimulated light can reflect back and forth, allowing only a certain wavelength to be emitted. The emission of a given device is determined by the active compound used (e.g., gallium arsenide crystals doped with aluminum or indium). Typical wavelengths are 810, 1,060 and 1,300 nm. (From UMDNS, 2005)Pulse Radiolysis: Use of a pulse of X-rays or fast electrons to generate free radicals for spectroscopic examination.Corrosion: The gradual destruction of a metal or alloy due to oxidation or action of a chemical agent. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Steel: A tough, malleable, iron-based alloy containing up to, but no more than, two percent carbon and often other metals. It is used in medicine and dentistry in implants and instrumentation.Rutin: A flavonol glycoside found in many plants, including BUCKWHEAT; TOBACCO; FORSYTHIA; HYDRANGEA; VIOLA, etc. It has been used therapeutically to decrease capillary fragility.Oxidation-Reduction: A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).Corrosion Casting: A tissue preparation technique that involves the injecting of plastic (acrylates) into blood vessels or other hollow viscera and treating the tissue with a caustic substance. This results in a negative copy or a solid replica of the enclosed space of the tissue that is ready for viewing under a scanning electron microscope.Free Radicals: Highly reactive molecules with an unsatisfied electron valence pair. Free radicals are produced in both normal and pathological processes. They are proven or suspected agents of tissue damage in a wide variety of circumstances including radiation, damage from environment chemicals, and aging. Natural and pharmacological prevention of free radical damage is being actively investigated.Polycyclic Hydrocarbons, Aromatic: A major group of unsaturated cyclic hydrocarbons containing two or more rings. The vast number of compounds of this important group, derived chiefly from petroleum and coal tar, are rather highly reactive and chemically versatile. The name is due to the strong and not unpleasant odor characteristic of most substances of this nature. (From Hawley's Condensed Chemical Dictionary, 12th ed, p96)Benzo(a)pyrene: A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.Uterus: The hollow thick-walled muscular organ in the female PELVIS. It consists of the fundus (the body) which is the site of EMBRYO IMPLANTATION and FETAL DEVELOPMENT. Beyond the isthmus at the perineal end of fundus, is CERVIX UTERI (the neck) opening into VAGINA. Beyond the isthmi at the upper abdominal end of fundus, are the FALLOPIAN TUBES.Polycyclic Compounds: Compounds consisting of two or more fused ring structures.Environmental Pollutants: Substances or energies, for example heat or light, which when introduced into the air, water, or land threaten life or health of individuals or ECOSYSTEMS.Agrochemicals: Chemicals used in agriculture. These include pesticides, fumigants, fertilizers, plant hormones, steroids, antibiotics, mycotoxins, etc.Pseudoephedrine: A phenethylamine that is an isomer of EPHEDRINE which has less central nervous system effects and usage is mainly for respiratory tract decongestion.Contract Services: Outside services provided to an institution under a formal financial agreement.Phenylpropanolamine: A sympathomimetic that acts mainly by causing release of NOREPINEPHRINE but also has direct agonist activity at some adrenergic receptors. It is most commonly used as a nasal vasoconstrictor and an appetite depressant.Ephedrine: A phenethylamine found in EPHEDRA SINICA. PSEUDOEPHEDRINE is an isomer. It is an alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used for asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists.Phosgene: A highly toxic gas that has been used as a chemical warfare agent. It is an insidious poison as it is not irritating immediately, even when fatal concentrations are inhaled. (From The Merck Index, 11th ed, p7304)Respiration, Artificial: Any method of artificial breathing that employs mechanical or non-mechanical means to force the air into and out of the lungs. Artificial respiration or ventilation is used in individuals who have stopped breathing or have RESPIRATORY INSUFFICIENCY to increase their intake of oxygen (O2) and excretion of carbon dioxide (CO2).Masks: Devices that cover the nose and mouth to maintain aseptic conditions or to administer inhaled anesthetics or other gases. (UMDNS, 1999)Equipment and Supplies: Expendable and nonexpendable equipment, supplies, apparatus, and instruments that are used in diagnostic, surgical, therapeutic, scientific, and experimental procedures.Device Approval: Process that is gone through in order for a device to receive approval by a government regulatory agency. This includes any required preclinical or clinical testing, review, submission, and evaluation of the applications and test results, and post-marketing surveillance. It is not restricted to FDA.Equipment Safety: Freedom of equipment from actual or potential hazards.Chlorides: Inorganic compounds derived from hydrochloric acid that contain the Cl- ion.Musculoskeletal Diseases: Diseases of the muscles and their associated ligaments and other connective tissue and of the bones and cartilage viewed collectively.Safety: Freedom from exposure to danger and protection from the occurrence or risk of injury or loss. It suggests optimal precautions in the workplace, on the street, in the home, etc., and includes personal safety as well as the safety of property.Human Engineering: The science of designing, building or equipping mechanical devices or artificial environments to the anthropometric, physiological, or psychological requirements of the people who will use them.ThymineStatic Electricity: The accumulation of an electric charge on a objectSulfonamides: A group of compounds that contain the structure SO2NH2.SulfathiazolesSulfisoxazole: A short-acting sulfonamide antibacterial with activity against a wide range of gram- negative and gram-positive organisms.Dihydropteroate Synthase: An enzyme that catalyzes the formation of dihydropteroate from p-aminobenzoic acid and dihydropteridine-hydroxymethyl-pyrophosphate. EC 2.5.1.15.Sulfadiazine: One of the short-acting SULFONAMIDES used in combination with PYRIMETHAMINE to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections.

Both the antioxidant and D3 agonist actions of pramipexole mediate its neuroprotective actions in mesencephalic cultures. (1/804)

Pramipexole (PPX) is a full intrinsic activity, direct-acting dopamine (DA) agonist possessing 7-fold higher affinity for D3 than for D2 receptors. It also is a potent antioxidant. PPX was previously shown to be neuroprotective because it dose dependently attenuated the DA neuron loss produced by levodopa in mesencephalic cultures. Several different drugs with properties similar to PPX were studied here to better understand the mechanism or mechanisms responsible for this neuroprotective effect. The D3-preferring agonist 7-hydroxy-diphenylaminotetralin (7-OH-DPAT) and the D3 antagonist U99194, respectively, increased and decreased the neuroprotective effects of PPX in a dose-dependent fashion. Addition of the selective D2 agonist U95666 or the D2/D3 antagonists domperidone or raclopride did not affect PPX's neuroprotective effect. Interestingly, 7-OH-DPAT by itself did not attenuate the DA neuron loss produced by levodopa. However, when 7-OH-DPAT was combined with a low dose of the antioxidants U101033E or alpha-tocopherol, the toxic effects of levodopa were attenuated. Similar results were observed when the D3-preferring agonist PD128, 907 was studied. In addition, media conditioned by exposure of mesencephalic cultures incubated with all D3-preferring agonists studied was shown to enhance the growth of DA neurons in freshly harvested recipient cultures implicating a D3-mediated trophic activity in the neuroprotective effect. These data suggest that PPX's neuroprotective actions in the levodopa toxicity model are a consequence of its combined actions as a D3 receptor agonist and an antioxidant.  (+info)

Aldose reductase functions as a detoxification system for lipid peroxidation products in vasculitis. (2/804)

Giant cell arteritis (GCA) is a systemic vasculitis preferentially affecting large and medium-sized arteries. Inflammatory infiltrates in the arterial wall induce luminal occlusion with subsequent ischemia and degradation of the elastic membranes, allowing aneurysm formation. To identify pathways relevant to the disease process, differential display-PCR was used. The enzyme aldose reductase (AR), which is implicated in the regulation of tissue osmolarity, was found to be upregulated in the arteritic lesions. Upregulated AR expression was limited to areas of tissue destruction in inflamed arteries, where it was detected in T cells, macrophages, and smooth muscle cells. The production of AR was highly correlated with the presence of 4-hydroxynonenal (HNE), a toxic aldehyde and downstream product of lipid peroxidation. In vitro exposure of mononuclear cells to HNE was sufficient to induce AR production. The in vivo relationship of AR and HNE was explored by treating human GCA temporal artery-severe combined immunodeficiency (SCID) mouse chimeras with the AR inhibitors Sorbinil and Zopolrestat. Inhibition of AR increased HNE adducts twofold and the number of apoptotic cells in the arterial wall threefold. These data demonstrate that AR has a tissue-protective function by preventing damage from lipid peroxidation. We propose that AR is an oxidative defense mechanism able to neutralize the toxic effects of lipid peroxidation and has a role in limiting the arterial wall injury mediated by reactive oxygen species.  (+info)

Efficacy, safety, and tolerance of the non-ergoline dopamine agonist pramipexole in the treatment of advanced Parkinson's disease: a double blind, placebo controlled, randomised, multicentre study. (3/804)

OBJECTIVES: Pramipexole, a non-ergot dopamine D2/D3 receptor agonist, was investigated as an add on drug in advanced parkinsonian patients with motor fluctuations to assess efficacy, safety, and tolerance. METHODS: Seventy eight patients of either sex with advanced Parkinson's disease and treatment complications such as motor fluctuations were enrolled into a double blind, placebo controlled, randomised, multicentre study (phase II) and assigned to add on treatment with pramipexole (n=34) versus placebo (n=44) to a previously stabilised antiparkinsonian medication (7 week dose titration interval, 4 week maintenance period). The primary end point of efficacy was the change from baseline in the total score of the unified Parkinson's disease rating scale (UPDRS) in the on "period" (2 hours after intake of study medication). Safety and tolerability were assessed on the basis of adverse events, vital signs, laboratory measurements, and ECG recordings. RESULTS: There was a significant improvement of the pramipexole group in UPDRS total scores, subscores part II, III (activities of daily living and motor examination), and IV (complications of therapy). Mean UPDRS total score decreased by 37.3% under pramipexole compared with 12.2% under placebo (p<0.001). Patients under pramipexole reported an overall reduction in "off" periods of 12%--resulting in 1.7 more hours "on" time a day--compared with an increase in "off" periods of 2% under placebo. There were no unexpected safety results. The adverse event profile disclosed a high tolerability. The most important adverse events under pramipexole were fatigue, dyskinesia, and vivid dreams. CONCLUSION: Pramipexole administration is an efficacious and well tolerated add on therapy in patients with advanced Parkinson's disease with an improvement in activities of daily living, motor function, and treatment associated complications.  (+info)

Primary active transport of organic anions on bile canalicular membrane in humans. (4/804)

Biliary excretion of several anionic compounds was examined by assessing their ATP-dependent uptake in bile canalicular membrane vesicles (CMV) prepared from six human liver samples. 2, 4-Dinitrophenyl-S-glutathione (DNP-SG), leukotriene C4 (LTC4), sulfobromophthalein glutathione (BSP-SG), E3040 glucuronide (E-glu), beta-estradiol 17-(beta-D-glucuronide) (E2-17G), grepafloxacin glucuronide (GPFXG), pravastatin, BQ-123, and methotrexate, which are known to be substrates for the rat canalicular multispecific organic anion transporter, and taurocholic acid (TCA), a substrate for the bile acid transporter, were used as substrates. ATP-dependent and saturable uptake of TCA, DNP-SG, LTC4, E-glu, E2-17G, and GPFXG was observed in all human CMV preparations examined, suggesting that these compounds are excreted in the bile via a primary active transport system in humans. Primary active transport of the other substrates was also seen in some of CMV preparations but was negligible in the others. The ATP-dependent uptake of all the compounds exhibited a large inter-CMV variation, and there was a significant correlation between the uptake of glutathione conjugates (DNP-SG, LTC4, and BSP-SG) and glucuronides (E-glu, E2-17G, and GPFXG). However, there was no significant correlation between TCA and the other organic anions, implying that the transporters for TCA and for organic anions are different also in humans. When the average value for the ATP-dependent uptake by each preparation of human CMVs was compared with that of rat CMVs, the uptake of glutathione conjugates and nonconjugated anions (pravastatin, BQ-123, and methotrexate) in humans was approximately 3- to 76-fold lower than that in rats, whereas the uptake of glucuronides was similar in the two species. Thus there is a species difference in the primary active transport of organic anions across the bile canalicular membrane that is less marked for glucuronides.  (+info)

Kinetic control of multiple forms of Ca(2+) spikes by inositol trisphosphate in pancreatic acinar cells. (5/804)

The mechanisms of agonist-induced Ca(2+) spikes have been investigated using a caged inositol 1,4,5-trisphosphate (IP(3)) and a low-affinity Ca(2+) indicator, BTC, in pancreatic acinar cells. Rapid photolysis of caged IP(3) was able to reproduce acetylcholine (ACh)-induced three forms of Ca(2+) spikes: local Ca(2+) spikes and submicromolar (<1 microM) and micromolar (1-15 microM) global Ca(2+) spikes (Ca(2+) waves). These observations indicate that subcellular gradients of IP(3) sensitivity underlie all forms of ACh-induced Ca(2+) spikes, and that the amplitude and extent of Ca(2+) spikes are determined by the concentration of IP(3). IP(3)-induced local Ca(2+) spikes exhibited similar time courses to those generated by ACh, supporting a role for Ca(2+)-induced Ca(2+) release in local Ca(2+) spikes. In contrast, IP(3)- induced global Ca(2+) spikes were consistently faster than those evoked with ACh at all concentrations of IP(3) and ACh, suggesting that production of IP(3) via phospholipase C was slow and limited the spread of the Ca(2+) spikes. Indeed, gradual photolysis of caged IP(3) reproduced ACh-induced slow Ca(2+) spikes. Thus, local and global Ca(2+) spikes involve distinct mechanisms, and the kinetics of global Ca(2+) spikes depends on that of IP(3) production particularly in those cells such as acinar cells where heterogeneity in IP(3) sensitivity plays critical role.  (+info)

Attenuation of ischemia induced increases in sodium and calcium by the aldose reductase inhibitor zopolrestat. (6/804)

OBJECTIVE: We have previously demonstrated that zopolrestat, an inhibitor of the enzyme aldose reductase, reduces ischemic injury in hearts from diabetic and non-diabetic rats. To further explore potential cardioprotective mechanisms of zopolrestat, we measured changes in intracellular sodium, calcium, and Na+,K(+)-ATPase activity in zopolrestat treated hearts during ischemia and reperfusion. METHODS: Hearts from acute diabetic (Type I) and age-matched control rats were isolated and retrogradely perfused. Hearts had either control perfusion or exposure to 1 microM zopolrestat for 10 min, followed by 20 min of global ischemia and 60 min of reperfusion. Changes in intracellular sodium and calcium were measured using 23Na and 19F magnetic resonance spectroscopy, respectively, while the activity of Na+,K(+)-ATPase was measured using biochemical assays. RESULTS: Zopolrestat blunted the rise in [Na]i during ischemia in both diabetic hearts and non-diabetic hearts. The end-ischemic [Na]i was 21.3 +/- 2.6 mM in the zopolrestat treated diabetics and 25.9 +/- 2.3 in zopolrestat treated non-diabetics, versus 31.6 +/- 2.6 mM and 32.9 +/- 2.8 mM in the untreated diabetics and untreated non-diabetics, respectively, (P = 0.002). Similarly, the rise in [Ca]i at the end of ischemia was significantly reduced in zopolrestat treated diabetic and non-diabetic hearts (P = 0.005). Zopolrestat increased the activity of Na-,K(+)-ATPase in diabetic hearts under baseline conditions (11.70 +/- 0.95 versus 7.28 +/- 0.98 mumol/h/mg protein, P = 0.005) as well as during ischemia and reperfusion. Similar changes in Na+,K(+)-ATPase activity were also observed in non-diabetic hearts. CONCLUSIONS: The data provide additional support to the protective effects of zopolrestat and suggest that a possible mechanism of action may be associated with the attenuation of the rise in [Na]i and [Ca]i during ischemia and reperfusion.  (+info)

Antioxidant activity: what do we measure? (7/804)

Inhibition of oxidation of 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) by free radicals generated by decomposition of 2,2'-azobis(2-amidopropane) (ABAP) by antioxidants and biological material was studied. A correlation was found between the ability of various substances to delay the onset of ABTS oxidation and their rapid reduction of the ABTS+* cation radical, and between the ability to reduce the maximal rate of ABTS oxidation and slow reduction of ABTS+*. The length of the lag period of ABTS oxidation was found to be independent of ABTS concentration. Similar decrease of peroxynitrite-induced ABTS+* formation by antioxidants was observed when the antioxidants were added before and after peroxynitrite. All these findings indicate that the main effect of antioxidants in this system is reduction of ABTS+* and not prevention of its formation. Reduction of oxidation products rather than inhibition of their formation may be the predominant mode of action of antioxidants in various assays of antioxidant activity.  (+info)

Malaria vectors in a traditional dry zone village in Sri Lanka. (8/804)

Malaria transmission by anopheline mosquitoes was studied in a traditional tank-irrigation-based rice-producing village in the malaria-endemic low country dry zone of northcentral Sri Lanka during the period August 1994-February 1997. Adult mosquitoes were collected from human and bovid bait catches, bovid-baited trap huts, indoor catches, and pit traps. Mosquito head-thoraces were tested for the presence of Plasmodium falciparum and P. vivax, and blood-engorged abdomens for the presence of human blood by ELISAs. House surveys were done at two-day intervals to record cases of blood film-confirmed malaria among the villagers. A total of 7,823 female anophelines representing 14 species were collected. Trends in anopheline abundance were significantly correlated with rainfall of the preceding month in An. annularis, An. barbirostris, An. subpictus, An. vagus, and An. varuna, but were not significant in An. culicifacies and An. peditaeniatus. Malaria parasite infections were seen in seven mosquito species, with 75% of the positive mosquitoes containing P. falciparum and 25% P. vivax. Polymorph PV247 was recorded from a vector (i.e., An. varuna) for the first time in Sri Lanka. Computations of mean number of infective vector (MIV) rates using abundance, circumsporozoite (CS) protein rate, and human blood index (HBI) showed the highest rate in An. culicifacies. A malaria outbreak occurred from October 1994 to January 1995 in which 45.5% of village residents experienced at least a single disease episode. Thereafter, malaria incidence remained low. Anopheles culicifacies abundance lagged by one month correlated positively with monthly malaria incidence during the outbreak period, and although this species ranked fifth in terms of abundance, infection was associated with a high MIV rate due to a high CS protein rate and HBI. Abundance trends in other species did not correlate significantly with malaria. It was concluded that An. culicifacies was epidemiologically the most important vector in the study area.  (+info)

*Erythrobacter

Hu, Youcai; MacMillan, John B. (16 December 2011). "Erythrazoles A-B, Cytotoxic Benzothiazoles from a Marine-Derived ...

*Surendra Nath Pandeya

His research focused on semicarbazones, Mannich bases, thiadiazoles, benzothiazoles, and oxindole compounds. Dr. S.N. Pandeya ...

*Thiazole

... s are found in a variety of specialized products, often fused with benzene derivatives, the so-called benzothiazoles. ... The following anthroquinone dyes contain benzothiazole subunits: Algol Yellow 8 (CAS# [6451-12-3]), Algol Yellow GC (CAS# [129- ... Other important thiazole dervatives are benzothiazoles, for example, the firefly chemical luciferin. Whereas thiazoles are well ...

*Primuline

... is a dye containing the benzothiazole ring system. Primuline itself is also known as Direct yellow 7, Carnotine, or C ...

*Julia olefination

The most popular example is the benzothiazole sulfone.[14] The reaction of the benzothiazole sulfone (1) with lithium ... It proceeds with the same mechanism as the benzothiazole sulfone above. The high E-selectivity of the Julia-Kocienski ... Since the benzothiazole variation of the Julia olefination does not involve equilibrating intermediates, the stereochemical ...

*Benzoxazole

Benzothiazole, an analog with the oxygen replaced by a sulfur. Benzopyrrole or indole, an analog without the oxygen atom. ...

*2-Aminothiophenol

It is a precursor to benzothiazoles, some of which are bioactive or are dyes. Isomers of aminothiophenols include 3- ...

*Sulfur dye

These dyes are proposed to consist of polymers with benzothiazole subunits. Members of the sulfur bake dyes class are Sulfur ...

*Cefroxadine

This undergoes fragmentation when treated with benzothiazole-2-thiol to give 2. Ozonolysis (reductive work-up) cleaves the ...

*Biological pigment

The compounds benzothiazole and tetrahydroisoquinoline ring systems act as UV-absorbing compounds. There are several different ...

*Alcian yellow

Its structure consists of a largely conjugated array of benzene, benzothiazole and isothiouronium units. Alcian yellow is used ...

*2-sec-Butyl-4,5-dihydrothiazole

... nitrile and the formation of thiazolines and benzothiazoles". Tetrahedron. 40 (11): 2141. doi:10.1016/S0040-4020(01)88457-X. ...

*Decarboxylative cross-coupling

... benzothiazoles, and benzoxazoles. The position of the nitrogen atom in the '2' position relative to the linkage is found to be ...

*Benzothiazine

Phenothiazine has an additional benzene ring Benzothiazole is another heterocycle containing nitrogen and sulfur 1. Sulfostyril ...

*Mercaptobenzothiazole

... advances were reported in the 1920's that included demonstration that phenyldithiocarbamates pyrolyze to benzothiazole ...

*Firefly luciferase

Another mechanism proposes that twisting the angle between benzothiazole and thiazole rings in oxyluciferin determines the ...

*Fostedil

... constructs the benzothiazole ring. Bromination of this compound with N-bromosuccinimide produces bromomethyl intermediate. The ...

*Old person smell

Another study failed to detect 2-nonenal at all, but found significantly increased concentrations of benzothiazole, ...

*Dexpramipexole

KNS-760704 [(6R)-4,5,6,7-tetrahydro-N6-propyl-2, 6-benzothiazole-diamine dihydrochloride monohydrate] for the Treatment of ...

*Thioflavin

... T (Basic Yellow 1 or CI 49005) is a benzothiazole salt obtained by the methylation of dehydrothiotoluidine with ...

*Firefly luciferin

Alkaline solutions caused a redshift of the absorption likely due to deprotonation of the hydroxyl group on the benzothiazole, ...

*Structural scheduling of synthetic cannabinoids

... benzothiazole, carbazole, imidazole, indane, indazole, indene, indole, pyrazole, pyrazolopyridine, pyridine, or pyrrole. (2) " ...

*List of MeSH codes (D03)

... benzothiazoles MeSH D03.383.129.708.089.222 --- dithiazanine MeSH D03.383.129.708.089.416 --- ethoxzolamide MeSH D03.383. ...

*Pittsburgh compound B

Mathis synthesised charge neutral benzothiazoles derived from thioflavin T, which included a small number of compounds with ...

*Herz reaction

3-benzothiazole 4. Aniline 5 is converted to compound 6, in three steps; conversion to an ortho-aminothiol through the Herz- ...

*Pseudogymnoascus destructans

A recent study (2014) identified several volatile organic compounds (benzaldehyde, benzothiazole, decanal, nonanal, N,N- ...
Benzothiazole derivatives corresponding to the general formula I ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 represent, independently of one another, a hydrogen atom, a halogen atom, a linear C.sub.1 -C.sub.3 -alkyl group or a linear C.sub.1 -C.sub.3 -alkoxy group, R.sup.5 represents a hydrogen atom or a linear C.sub.1 -C.sub.3 -alkyl group, R.sup.6 represents a hydrogen atom, and R.sup.7 represents a formyl group, a carbalkoxy group of the formula ##STR2## wherein R.sup.8 denotes a linear or branch chained C.sub.1 -C.sub.4 -alkyl group, or it represents an acyl group of the formula ##STR3## wherein R.sup.9 denotes a linear C.sub.1 -C.sub.3 -alkyl group, or R.sup.6 and R.sup.7 together represent the group ##STR4## wherein R.sup.10 and R.sup.11 represent, independently of one another, a hydrogen atom or a linear C.sub.1 -C.sub.6 -alkyl group or R.sup.6 and R.sup.7 represent the group ##STR5## wherein R.sup.12 and R.sup
2-methyl-5-(trifluoromethyl)-1,3-benzothiazole 398-99-2 NMR spectrum, 2-methyl-5-(trifluoromethyl)-1,3-benzothiazole H-NMR spectral analysis, 2-methyl-5-(trifluoromethyl)-1,3-benzothiazole C-NMR spectral analysis ect.
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Saccharin belongs to a class of cyclic sulfonamides and this is used as an artificial sweetener for a longtime. The benzothiazole and quinazoline derivatives form an important classes of fused heterocyclic compounds with a wide range of biological activities such as antimicrobial (Schwartz et al., 1992), anticancer (Wolfe et al., 1990), antiinflammatory (Tereshima et al., 1995). As a part of our studies in this area, the molecular and crystal structures of the title compound have been determined and the results are presented here.. The title compound comprises a benzothiazole ring fused with quinazoline ring. X-ray analysis confirms the molecular structure and atom connectivity as illustrated in Fig. 1. The benzothiazole ring system is essentially planar with a maximum deviation of -0.0127 (16)Å for the C7 atom. The quinazoline ring system is also essentially planar with the maximum deviation of -0.1588 (15)Å for the N1 atom. The dihedral angle between the benzothiazole and quinazoline ring ...
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NVP-231: A Competitive CerK Inhibitor. We developed a homogeneous CerK assay for high-throughput screening based on a luminescent reaction measuring ATP consumption (Koresawa and Okabe, 2004; Klumpp et al., 2006). After miniaturization of this assay to a 1536-well plate format, we screened over a million compounds for inhibition of CerK. Primary hits active in the micromolar range were confirmed or invalidated by dose-response experiments, which also provided a preliminary ranking. The overlap to hit lists from other kinase inhibitor screens using the same assay principle was very limited, indicating specificity of the hit compounds for CerK. Although the screened libraries contained many typical protein kinase inhibitors, only a few of them inhibited CerK. Further hit validation was conducted using a direct enzymatic assay measuring the incorporation of radioactive phosphate into C1P.. One of the compounds identified as the benzothiazole derivative 1 (or NVP-231) showed an IC50 value of 12 ± 2 ...
2-(1,2-benzothiazol-3-yl)ethyl acetate | C11H11NO2S | CID 590633 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
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Learn more about 1-4-6-dimethyl-1-3-benzothiazol-2-yl-piperidine-3-carboxylic-acid. We enable science by offering product choice, services, process excellence and our people make it happen.
4AJN: rat LDHA in complex with 2-((4-(2-((3-((2-methyl-1,3-benzothiazol-6- yl)amino)-3-oxo-propyl)carbamoylamino)ethyl)phenyl)methyl) propanedioic acid
N-(1,3-benzothiazol-2-ylmethyl)benzamide - chemical structural formula, chemical names, chemical properties, synthesis references
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(8S,9S,13S,14S)-3-hydroxy-13-methyl-2,4-dinitro-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one Butanedioic acid,(tetrahydro-2-furanyl)- 2-(chloromethylsulfanyl)benzothiazole 1,2-Benzenedicarboxylic acid, mixed esters with isooctanol and neopentyl glycol ethyl (Z)-3-diethoxyphosphoryloxy-3-phenyl-prop-2-enoate 36626-29-6 3-(7-methyl-6-azabicyclo[3.2.1]oct-1-yl)phenol hydrobromide Testosterone 17beta-carboxylic acid 1-Piperazineethanol, 4-(3-(diphenylamino)-1-oxopropyl)-, acetate (ester) 1-[5-fluoro-4-[4-(2-fluoro-5-methyl-4-nitro-phenyl)piperazin-1-yl]-2-methyl-phenyl]ethanone
Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned ...
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Small-conductance (KCa2) and intermediate-conductance (KCa3.1) calcium-activated K+ channels are voltage-independent and share a common calcium/calmodulin-mediated gating mechanism. Existing positive gating modulators like EBIO, NS309, or SKA-31 activate both KCa2 and KCa3.1 channels with similar potency or, as in the case of CyPPA and NS13001, selectively activate KCa2.2 and KCa2.3 channels. We performed a structure-activity relationship (SAR) study with the aim of optimizing the benzothiazole pharmacophore of SKA-31 toward KCa3.1 selectivity. We identified SKA-111 (5-methylnaphtho[1,2-d]thiazol-2-amine), which displays 123-fold selectivity for KCa3.1 (EC50 111 ± 27 nM) over KCa2.3 (EC50 13.7 ± 6.9 μM), and SKA-121 (5-methylnaphtho[2,1-d]oxazol-2-amine), which displays 41-fold selectivity for KCa3.1 (EC50 109 nM ± 14 nM) over KCa2.3 (EC50 4.4 ± 1.6 μM). Both compounds are 200- to 400-fold selective over representative KV (KV1.3, KV2.1, KV3.1, and KV11.1), NaV (NaV1.2, NaV1.4, NaV1.5, and ...
The criteria for diagnosing Alzheimers disease (AD) have recently been revised to include the use of biomarkers for the in vivo presence of β-amyloid, one of the neuropathological hallmarks of AD. Examples of such biomarkers are positron emission tomography (PET) β-amyloid specific ligands, including [18F]flutemetamol. The aim of this thesis was to characterize the binding properties of [18F]flutemetamol from a tracer kinetic perspective as well as by validating binding measures through comparison with tissue pathology assessments. The applicability of previously developed kinetic models of tracer binding for voxel-based analysis was examined and compared to arterial input compartment modelling, the "gold standard" for PET quantification. Several voxel-based methods were found to exhibit high correlations with compartment modelling, including the semi-quantitative standardized uptake value ratio (SUVR). The kinetic components of [18F]flutemetamol uptake were also investigated without model ...
Patients should be instructed to take pramipexole dihydrochloride tablets only as prescribed. Patients should be alerted to the potential sedating effects associated with pramipexole dihydrochloride tablets, including somnolence and the possibility of falling asleep while engaged in activities of daily living. Since somnolence is a frequent adverse event with potentially serious consequences, patients should neither drive a car nor engage in other potentially dangerous activities until they have gained sufficient experience with pramipexole dihydrochloride tablets to gauge whether or not it affects their mental and/or motor performance adversely. Patients should be advised that if increased somnolence or new episodes of falling asleep during activities of daily living (e.g., watching television, passenger in a car, etc.) are experienced at any time during treatment, they should not drive or participate in potentially dangerous activities until they have contacted their physician. Because of ...
Preliminary irritation study: The necrosis seen at intradermal injection of the lowest concentration (2%) was considered to be caused mainly by polyethylene glycol rather than the test substance. Based on the results, the test substance concentrations selected for the main study were a 2% concentration for the intradermal induction and a 50% concentration for the epidermal induction exposure. No signs of irritation were observed to the highest test substance concentration epidermally tested. Therefore, the test site of all animals was treated with 10% SDS approximately 24 hours before the epidermal induction in the main study, to provoke a mild inflammatory reaction. A 50% test substance concentration was selected for the challenge phase. Main study results: -Induction phase: The signs of necrosis seen in the control animals after the intradermal injection with vehicle only were in consistency with the results in the preliminary irritation study after injection of polyethylene glycol. The ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
When using this server please cite the following paper:. Zsila F, Bikadi Z, Malik D, Hari P, Pechan I, Berces A, Hazai E.. Evaluation of drug-human serum albumin binding interactions with support vector machine aided online automated docking.. Bioinformatics. 2011 May 18. ...
Pramipexole Tablet is a medicine that is used for the treatment of Parkinson Disease and other conditions. Pramipexole Tablet contains Pramipexole
Patients initially randomized to placebo, received placebo for 6-9 months, then up-titrated from 0.375 mg pramipexole daily to 1.5 mg pramipexole daily over a 6 week period. These patients were then continued on 1.5 mg pramipexole daily for the remainder of the 15 months of the study ...
Patients initially randomized to placebo, received placebo for 6-9 months, then up-titrated from 0.375 mg pramipexole daily to 1.5 mg pramipexole daily over a 6 week period. These patients were then continued on 1.5 mg pramipexole daily for the remainder of the 15 months of the study ...
ORCID: 0000-0001-8401-5223, Moffatt, Colin and Smith, Robert B (2013) N-Alkylated 2,3,3-trimethylindolenines and 2-methylbenzothiazoles. Potential lead compounds in the fight against Saccharomyces cerevisiae infections. European journal of medicinal chemistry, 64 . pp. 222-227. ISSN 1768-3254 Okoh, Adeyi Okoh, Bisby, RH, Lawrence, Clare Louise, Rolph, Carole Elizabeth and Smith, Robert B (2013) Promising near-infrared non-targeted probes: benzothiazole heptamethine cyanine dyes. Journal of Sulfur Chemistry, 35 (1). pp. 42-56. ISSN 1741-5993 Brocklesby, Kayleigh L., Johns, Stephen C., Jones, Allison E., Sharp, Duncan and Smith, Robert B (2013) Smart bandages - A colourful approach to early stage infection detection & control in wound care. Medical Hypotheses, 80 (3). pp. 237-240. ISSN 03069877 Sharp, Duncan, Gladstone, Patience, Smith, Robert B, Forsythe, Stephen and Davis, James (2010) Approaching intelligent infection diagnostics: Carbon fibre sensor for electrochemical pyocyanin detection. ...
A new ratiometric fluorescent probe derived from 2-(2-hydroxy-3-methoxyphenyl) benzothiazole (HMBT) has been developed for selective monitoring of human carboxylesterase 1 (hCE1). The probe is designed by introducing benzoyl moiety to HMBT. The prepared latent spectroscopic probe 1 displays satisfying stability under physiological pH conditions with very low background signal. Both the reaction phynotyping and chemical inhibition assays demonstrated that hCE1 mediated the specific cleavage of the carboxylic ester bond of probe 1 in human biological samples. The release of HMBT leads to a remarkable red-shifted emission in fluorescence spectrum (120 nm large emission shift). Furthermore, human cell-based assays show that probe 1 is cell membrane permeable, and it can be used for bioassay and cellular imaging of hCE1 activity in HepG2 cells. These findings lead to the development of a simple and sensitive fluorescent method for measurement of hCE1 activity in vitro or in living cells, in the ...
Negrete-Raymond AC, Weder B, Wackett LP( 2003) Biographical Portrayal of original soils by Arthrobacter advances see PBA. Appl Environ Microbiol 69: 4263-4267. Haroune N, Combourieu B, Besse storage, Sancelme M, Reemtsma ortho-nitrophenol, et al. 2002) Benzothiazole protest by Rhodococcus cookies Ortschaften PA: 4-monooxygenase of a ter brain Vocabulary.
Besidski Y.; Brown W.; Bylund J.; Dabrowski M.; Dautrey S.; Harter M.; Horoszok L.; Hu Y.; Johnson D.; Johnstone S.; Jones P.; Leclerc S.; Kolmodin K.; Kers I.; Labarre M.; Labrecque D.; Laird J.; Lundstrom T.; Martino J.; Maudet M.; Munro A.; Nylof M.; Penwell A.; Rotticci D.; Slaitas A.; Sundgren-Andersson A.; Svensson M.; Terp G.; Villanueva H.; Walpole C.; Zemrībo R.; *Griffin A.M. Potent and orally efficacious benzothiazole amides as TRPV1 antagonists. Bioorg. Med. Chem. Lett. 2012, 22(19), 6205-6211 ...
The criteria for diagnosing Alzheimers disease (AD) have recently been revised to include the use of biomarkers for the in vivo presence of β-amyloid, one of the neuropathological hallmarks of AD. Examples of such biomarkers are positron emission tomography (PET) β-amyloid specific ligands, including [18F]flutemetamol. The aim of this thesis was to characterize the binding properties of [18F]flutemetamol from a tracer kinetic perspective as well as by validating binding measures through comparison with tissue pathology assessments. The applicability of previously developed kinetic models of tracer binding for voxel-based analysis was examined and compared to arterial input compartment modelling, the "gold standard" for PET quantification. Several voxel-based methods were found to exhibit high correlations with compartment modelling, including the semi-quantitative standardized uptake value ratio (SUVR). The kinetic components of [18F]flutemetamol uptake were also investigated without model ...
Previous studies have demonstrated clearly that different cell types in vitro may be exquisitely sensitive or markedly resistant to the drug (Shi et al., 1996; Bradshaw et al., 1998b; Chua et al., 1999). This suggests that definition of "sensitive" potentially responding tumor phenotypes would be important in early clinical trials and allow a more accurate assessment of therapeutic index. Moreover, patients with tumors displaying intrinsic resistance to benzothiazoles would be spared unnecessary toxicity.. Activation of phase I enzymes, such as CYP1A1 and CYP1B1, usually occurs as a response in cells to promote detoxification of toxic agents such as benzo[a]pyrene, a polycyclic aromatic hydrocarbon. It was also described that the environmental pollutant TCDD, which is a potent agonist of AhR, induces CYP1A1 and modulatesCYP1B1 expression in MCF-7 cells. TCDD is a nongenotoxic AhR ligand that has an antiestrogenic and thus antitumorigenic effect in rodent uterus and mammary cells and human breast ...
Frohn M, Cee VJ, Lanman BA, Pickrell AJ, Golden JE, Rivenzon-Segal D, Middleton S, Fiorino M, Xu H, Schrag M, et al. Novel 5-and 6-subtituted benzothiazoles with improved physicochemical properties: Potent S1P(1) agonists with in vivo lymphocyte-depleting activity. Bioorganic & Medicinal Chemistry Letters. 2012 ;22:628-633. ...
Frohn M, Cee VJ, Lanman BA, Pickrell AJ, Golden JE, Rivenzon-Segal D, Middleton S, Fiorino M, Xu H, Schrag M, et al. Novel 5-and 6-subtituted benzothiazoles with improved physicochemical properties: Potent S1P(1) agonists with in vivo lymphocyte-depleting activity. Bioorganic & Medicinal Chemistry Letters. 2012 ;22:628-633. ...
Pramipexole drug tablet (trade name Mirapexin). This drug is used in the treatment of Parkinsons disease. Parkinsons disease is a movement disorder caused by the loss of cells in the brain that produce dopamine, a neurotransmitter necessary for normal motor function. Pramipexole can activate dopamine receptors, mimicking the effect of the neurotransmitter. - Stock Image M625/1730
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... Systematic (IUPAC) name (6S)-N6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine Identifiers CAS number 104632-26-0 ATC code
AC220 (Quizartinib) is a uniquely potent and selective FLT3 inhibitor with IC50 of 0.56 ± 0.3 nM and >10 mM for MC4-11 and A375, respectively.
4AU8: Synthesis and Structure-Activity Relationship of 4-(1,3-Benzothiazol-2-Yl)-Thiophene-2-Sulfonamides as Cyclin-Dependent Kinase 5 (Cdk5)/P25 Inhibitors.
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Ingelheim, Germany (ots/PRNewswire) - - New Study Shows That Mirapexin(R)/Sifrol(R) (Pramipexole) Relieves Depressive Symptoms of Parkinsons Disease (PD), a Common Non-Motor...
The investigational tyrosine kinase inhibitor quizartinib is extremely promising as a monotherapy for patients with |em|FLT3-ITD–|/em|positive relapsed acute myeloid leukemia.
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This study was designed to investigate the activity of CGP 20376, a benzothiazole derivative, against Brugia malayi in jirds and to illustrate the utility of parasite antigen detection as a means of monitoring drug efficacy in filariasis. Drug treatment was 100% effective in jirds treated 3 or 24 days after infection. Microfilaria and adult worm counts were reduced (relative to counts in sham-treated control animals) by 96% and 95%, respectively, in animals treated 153 days after infection. Four of 6 animals in this treatment group cleared their microfilaremias and were free of adult worms 5 mo after treatment. Thus, CGP 20376 was effective against all life cycle stages of B. malayi in jirds. Parasite antigen levels in jird sera were consistent with parasitological results in all treatment groups, but antigen clearance was incomplete in some cases after apparently successful treatment of mature and immature infections.
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Close The Infona portal uses cookies, i.e. strings of text saved by a browser on the users device. The portal can access those files and use them to remember the users data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser. ...
Although the gold standard diagnostic tool for cardiac amyloidosis is endomyocardial biopsy (5), investigators have tried to assess this disease noninvasively with various imaging techniques. Although some molecular imaging-based methods have been successful (8,12), most of them have been unsuccessful for demonstrating amyloid deposits in the myocardium (13). The CMR has also been successful in the diagnosis of cardiac amyloidosis (14), but it may not be specific for amyloid deposits (15). Therefore, there is a clinical need to foster imaging-based diagnosis into clinical utility.. 11C-PiB has been used recently for early detection and for follow-up of Alzheimers dementia (16), a disease characterized by accumulation of β-amyloid plaque in the brain parenchyme. It is a radioactive derivative of benzothiazole that binds with conformational dependence to any type of β-amyloid sheet structure (7). Indeed, this has been demonstrated in various mouse models (17) and in human autopsy studies of the ...
2,2-Azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) is a peroxidase substrate suitable for use in ELISA procedures. This substrate produces a soluble end product that is green in color and can be read spectrophotometrically at 405 nm. The reaction may be stopped with 1% sodium dodecyl sulfate (SDS). Recommended for ELISA (microwell) procedures, not recommended for membrane applications ...
Buy Pramipexole For Parkinsons Disease. Pramipexole is a non-ergoline medication belonging to the class of dopamine agonists. It is used for the treatment of Parkinsons disease, and sometimes for Restless Legs Syndrome in its initial stages. In some cases, it can be prescribed for the treatment of cluster headache, and also for counteracting sexual dysfunction problems in patients using SSRI antidepressants. Pramipexole depression medication can also be used for treating clinical depression in certain patients, and also for treating fibromyalgia.. How the drug works. For Parkinsons disease, it restores dopamine balance in your brain, leading to improvement in your movements, and reduction in your unsteadiness, stiffness, shakiness and slowed movements. With the use of this drug, you can receive less number of attacks known as on-off syndrome. During these attacks, you are not able to move your body. For Restless Legs Syndrome, it works by relieving the unpleasant feelings in your legs during ...
Tozadenant RO-449351 SYN-115 Molecular Formula C19H26N4O4S Average mass 406.499 Da A2 (3); A2a-(3); RO4494351; RO4494351-000; RO4494351-002; SYN-115 Phase III clinical trials at Biotie Therapies for the treatment of Parkinsons disease as an adjunctive therapy with levodopa 1-Piperidinecarboxamide, 4-hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl- 4-Hydroxy-N-[4-methoxy-7-(4-morpholinyl)-1,3-benzothiazol-2-yl]-4-methyl-1-piperidinecarboxamide 4-Hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl-1-piperidinecarboxamide 4-Hydroxy-4-methyl-piperidine-1-carboxylic acid(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-amide CAS 870070-55-6 Originator Roche Developer Acorda Therapeutics Class Amides; Antiparkinsonians; Benzothiazoles; Carboxylic acids; Morpholines; Piperidines; Small molecules Mechanism…
It is inherently undesirable for any chemical component of the rubber to migrate into a foodstuff during processing or storage. Rubber compounds are complex formulations that undergo chemical transformation during vulcanisation.. Rubber components that can potentially migrate include low molecular mass monomers, vulcanising agents, plasticisers, oils and waxes and their breakdown products. For example, polar plasticisers such as di-2-ethylhexyl phthalate are readily soluble in alcohol so plasticised rubbers should not be used in contact with alcoholic beverages.. The compounds 2-mercaptobenzothiazole (MBT) and benzothiazole (BT) may migrate from rubber during the manufacture and storage of food or drink. Research has shown that this might happen. Both MBT and BT migrated from rubber into laboratory solvents.. The main types of rubber components where residues of MBT and BT may be found include natural rubber or nitrile rubber seals and gaskets used in food processing equipment. MBT is formed ...
Stupp, R., Tosoni, A., Bromberg, J. E. C., Hau, Peter, Campone, M., Gijtenbeek, J., Frenay, M., Breimer, L., Wiesinger, H., Allgeier, A., van den Bent, M. J., Bogdahn, Ulrich, van der Graaf, W., Yun, H. J., Gorlia, T., Lacombe, D. and Brandes, A. A. (2011) Sagopilone (ZK-EPO, ZK 219477) for recurrent glioblastoma. A phase II multicenter trial by the European Organisation for Research and Treatment of Cancer (EORTC) Brain Tumor Group. Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 22 (9), pp. 2144-2149 ...
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Close The Infona portal uses cookies, i.e. strings of text saved by a browser on the users device. The portal can access those files and use them to remember the users data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser. ...
The three organometallic complexes [(Cis-Pt^II (DDH) (2,5- Dihidroxibenzensulfonic)^2, Rh^I (CO)2 Cl(2- Aminobenzothiazole) and Rh^I (CO)2 Cl(5-Cl-2- Methilbenzothiazole)] used in this study had been previously found to have a high in vitro activity against promastigote and amastigote like forms of Leishmania donovani. Here, the cytotoxic effect of these new organometallic complexes on the J-774 macrophages were studied. Only the Rh^I(CO)2 Cl (2-Aminobenzothiazole) complex induced substantial toxicity in the cells.. Also, we assayed the effect of this complex on the parasite s biosynthesis of macromolecules. The Rh^I(CO)2Cl (5-Cl-2- Methylbenzothiazole) complex inhibited DNA, RNA, and protein synthesis. On the other hand, the two other compounds tested did not inhibit the incorporation of radioactive precursors. Finally important ultrastructural alterations in the parasites treated with the two non-cytotoxic complexes were observed ...
A number of compounds of interest as possible purine or pyrimidine antagonists have been assayed for anti-leukemic action against transplanted lymphoid leukemia (Ak 4) in mice.. The pyrimidines studied were uniformly inactive.. Of the 2,6-diaminopurine derivatives assayed, only the parent compound definitely increased survival time. Introduction of a hydroxy, mercapto, or iodo group at the 8-position of 2,6-diaminopurine apparently inactivates this anti-leukemic molecule.. Benzimidazole, 2-chloromethylbenzimidazole, 5-nitrobenzotriazole, indole, benzoxazole, benzothiazole, 2-methyl-4-hydroxyquinazoline, and 2,3,5-triphenyltetrazolium chloride were screened but showed no anti-leukemic activity.. ...
Nawrocki, S. T., K. D. Drake, C. F. Watson, G. D. Foster, and K. J. Maier. (2005). Comparative aquatic toxicity evaluation of 2-(thiocyanomethylthio) benzothiazole (TCMTB) and selected degradation products using Ceriodaphnia dubia. Arch. Environ. Contam. Toxicol. 48: 344-350. Maier, K. J., J. L. Stobbe and K. D. Drake. (2003) Response to Letter to the Editor (re: Stobbe et al., 2003). International Journal of Toxicology 22:475-478. Stobbe, J. L., K. D. Drake, and K. J. Maier. (2003). Comparison of in vivo (Draize method) and in vitro (Corrositex assay) dermal corrosion values for selected industrial chemicals. International Journal of Toxicology 22:99-107. Davis, S. M., K. D. Drake, and K. J. Maier. (2002). Toxicity of boron to the duckweed, Spirodella polyrrhiza. Chemosphere. 48: 615-620. Dethloff, G. M., H. C. Bailey and K. J. Maier. (2001). Effects of dissolved copper on select hematological, biochemical and immunological parameters of wild rainbow trout (Onchrhynchus mykiss). Arch. Environ. ...
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Haploinsufficiency of Meis1 is a potential model system for simulating RLS in mice. Here, we show that this Meis1 deficit causes a sex- and context-dependent RLS-related phenotype at middle age, impaired sensorimotor gating ability that was refractory to the D2/3R agonist pramipexole as well as increased social memory. These behavioral abnormalities occurred without differences in thermal sensitivity, plasma iron concentrations or dopaminergic neuron number in the SNpc/VTA. Thus, although Meis1 haploinsufficiency causes the RLS-related phenotype of motor restlessness in mice, the detailed nature of these effects is complex. Furthermore, it is characteristically distinct from other genetic RLS models (e.g. Btbd9 knock-out), highlighting the heterogeneous nature of the effects of these different risk genotypes in this disease.. Motor restlessness in these Meis1-haploinsufficient mice was detected previously in young adult male and female mice (Spieler et al., 2014). RLS is, however, more prevalent ...
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Pramipexole is used alone or with other medications to treat Parkinsons disease. It can improve your ability to move and can decrease shakiness (trem
Eyebrows have been raised after Astellas Pharma decided to end its collaboration with Ambit Biosciences Corp to develop the latters acute myeloid leukaemia treatment quizartinib. - News - PharmaTimes
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam ...
Herbal medicine is an important part of health care system in most of the countries. Rubus fairholmianus is an unexplored berry in folkloric medicine. In this study, we aimed to understand the importance of R. fairholmianus in pharmaceutical industry for the development of cost-effective cancer therapeutic drugs using in vivo and in vitro analysis. Chemical characterization, antioxidant, antiproliferative and apoptosis inducing properties of R. fairholmianus root methanolic column subfraction (RFM) were investigated. The RFM displayed the presence of alpha-tocopherol, flavonol glycoside and apigenin in the chemical characterization. DPPH (2, 2-diphenyl-1-picrylhydrazyl) and ABTS (2, 2-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid)) radical scavenging assays exhibited an activity of 7.56 g/mL (IC ) and 20514.7 M trolox equivalents/g respectively. The solid and ascites tumors in mice were reduced significantly upon 100 mg/kg RFM treatment by reducing the tumor volume (1.86 cm ), tumor weight ...
Millions of people worldwide living with RLS to benefit as treatment becomes globally available, , , , Ingelheim/Germany, 10 November 2006 - Boehringer Ingelheim announced today that the U.S. Food and Dr...
Introduction of lysine linkage in the conjugate between abasic site-binding ligands and thiazole orange significantly improved the binding affinity for target orphan adenine or uracil nucleobase in DNA/RNA hybrids.
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2-((2-Aminophenyl)thio)phenyl)(4-(2-(2-hydroxyethoxy)ethyl)piperazin-1-yl)methanone ;. CAS # 848814-27-7 ;. C21H27N3O3S ;. MW: 401.52 ;. ...
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Allosteric inhibition of coagulation enzymes offers the advantage of controlled inhibition. In this study, a small library of mono sulfated indole and benzothiazole based molecules was synthesized and screened against the panel of coagulation proteases. The results reveal that selected molecules inhibit the thrombin, factor Xa and factor XIa with moderate potency. Compound 6a was found to have an allosteric mode of inhibition against thrombin. Plasma clotting assays suggest that selected inhibitors 14b, 14c and 14d prolong both prothrombin and activated partial thromboplastin time. Overall, this work presents the newer class of allosteric inhibitors of thrombin and factor XIa with improved aqueous solubility profile.. KEYWORDS: Anticoagulation; Factor XIa; Sulfation; Thrombin. ...
A new screening system can identify compounds that might inhibit huntingtin protein aggregation in Huntingtons disease (HD). Initial testing points to the benzothiazole family of compounds as potential therapies for the disease, according to a report in the current early online edition of Proceedings of the National Academy of Sciences.. Erich Wanker, Volker Heiser, and colleagues at the Max Planck Institute for Molecular Genetics in Berlin, and Merck in Darmstadt, Germany, report that they have developed a filter retardation assay based on the fact that polyQ-containing protein aggregates (of which huntingtin is one) are resistant to denaturing by sodium dodecyl sulphate (SDS). The aggregates will be retained on a cellulose acetate filter, whereas SDS-soluble proteins are not. Taking advantage of these properties, the researchers created a medium-throughput screening system that could evaluate the poly-Q aggregate-inhibiting properties of hundreds of chemical agents at once.. Among the almost ...
We report the synthesis and characterization of novel mixed-metal binuclear ruthenium(ii)-cobalt(ii) photocatalysts for hydrogen evolution in acidic acetonitrile. First, 2-(2′-pyridyl)benzothiazole (pbt), 1, was reacted with RuCl3·xH2O to produce [Ru(pbt)2Cl2]·0.25CH3COCH3, 2, which was then reacted with 1,1 Dalton Discussion 13: Inorganic photophysics and photochemistry -Fundamentals and applications
... Granules - soft Benzothiazole disulfide (2,2I- Dithio-dibenzothiazole) general purpose accelerator for sulfur cures active above 142°C (287°F). For use in natural and synthetic rubber processing.
159 ##STR00223## 3-(5-(2,5-difluorophenyl)-3-(6-(3-methyl-1H- 1,2,4-triazol-1-yl)benzo[d]thiazol-2-yl)-2- phenyl-2,3-dihydro-1,3,4-thiadiazol-2- yl)propan-1-amine 160 ##STR00224## 3-(3-(benzo[d]oxazol-2-yl)-5-(2,5- difluorophenyl)-2-phenyl-2,3-dihydro-1,3,4- thiadiazol-2-yl)propan-1-amine 161 ##STR00225## 3-(5-(2,5-difluorophenyl)-3-(1-methyl-1H- benzo[d]imidazol-2-yl)-2-phenyl-2,3-dihydro- 1,3,4-thiadiazol-2-yl)propan-1-amine 162 ##STR00226## 2-(2-(3-aminopropyl)-5-(2,5-difluorophenyl)- 2-phenyl-1,3,4-thiadiazol-3(2H)-yl)-N,N- dimethyl-6,7-dihydrothiazolo[4,5-c]pyridine- 5(4H)-carboxamide 163 ##STR00227## 2-(2-(3-aminopropyl)-5-(2,5-difluorophenyl)- 2-phenyl-1,3,4-thiadiazol-3(2H)-yl)-N,N- dimethyl-6,7-dihydrothiazolo[5,4-c]pyridine- 5(4H)-carboxamide 164 ##STR00228## 3-(5-(2,5-difluorophenyl)-3-(6-methyl-6,7- dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)-2- phenyl-2,3-dihydro-1,3,4-thiadiazol-2- yl)propan-1-amine 165 ##STR00229## 3-(5-(2,5-difluorophenyl)-3-(imidazo[1,2- ...
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National biomonitoring programme Natural rubber has to undergo a series of processes to improve its properties to make it suitable for the myriad of products into which it is made. One process is vulcanisation, during which sulphur is added to improve the tensile strength, elasticity, abrasion resistance and swelling resistance. One common...
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FLT3-inhibitor quizartinib is granted the Orphan Drug designation in Japan for the treatment of acute myeloid leukaemia harbouring FLT3-mutations.
In the food industry, in the process of creating new agricultural plant products, and in the testing of anti-cancer drugs there is often a need to assay multiple samples of low molecular weight antioxidants, plant samples and foods rich in antioxidants, with minimal additional costs and low degrees of uncertainty. With these demands in mind, we decided to study the fully automated assay of antioxidants using not only automated sample measurements but also automated processing of samples and application of reagents. The automated pipetting system epMotion 5075 and the automated spectrophotometer BS 400 were chosen for the assay purposes. Five methods were introduced for the automation: 2-diphenyl-1-picrylhydrazyl (DPPH) test, ferric reducing antioxidant power (FRAP) method, 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) based test, N,N-dimethyl-1,4-diaminobenzene (DMPD) based test and the Free Radicals method. Samples containing one of the four antioxidants (standard rutin, ...
시중 유통 혼합잡곡 첨가 취반 밥 에탄올 추출물에 대한 radical 소거활성은 항산화물질에 의해 환원되어 짙은 자색 이 탈색됨으로써 항산화 물질의 전자공여능을 측정할 때 사용되고 있는 DPPH radical 소거활성(Nieva et al., 2000) 과 혈장에서 ABTS radical의 흡광도가 항산화제에 의해 억 제되는 것에 기초하여 개발된 ABTS radical 소거활성(Kim et al., 2009)을 측정한 결과 Fig. 4 및 Table 4와 같이 나타 났다. 전자공여능은 지질과산화의 연쇄반응에 관여하는 free radical에 전자를 공여하여 산화를 억제시키는 척도가 되며, free radical은 인체 내에서 각종질병과 세포의 노화를 일으 키므로 식물 추출물 등에서 항산화제로 작용할 수 있는 물질 을 확인할 필요성이 있다(Kim et al., 2009). 일반밥솥과 압 력밥솥으로 취반한 백미 추출물의 DPPH radical 소거활성은 각각 3.15±0.04 및 3.71±0.07 mg ...
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Before you begin taking a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should take this medication.. Behaviour changes: People taking pramipexole have experienced abnormal behaviour such as compulsive gambling, compulsive shopping, hypersexuality, and binge eating. If you experience these symptoms or any other behaviour change while taking this medication, contact your doctor immediately.. Blood pressure: Pramipexole can lower blood pressure for some people. People taking this medication may feel dizzy or lightheaded when rising from a sitting or lying position. Make sure to tell your doctor if you experience this effect. If you have severe heart disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and ...
Původ: Sebraný paní Molly M. Waldron z Walvis Bay v roce 1960, a pojmenovaný po ní. Rozšíření: Namibie, k JZ konci rozsahu druhu, to jest V a JV od Swakopmundu a v rozmezí okolo 80 km od města. TL JV od Swakopmundu, u Vogelfederbergu (C189). Hornina: Erodovaný (pískový) křemenec ...
Murine IFN-γ ELISA development kit contains the key components required for the quantitative measurement of natural and/or recombinant
Increasingly stringent environmental legislation and indispensable use of fungicides in the tanning industry obliges tanners to adapt their processes to alternative technologies with lower environmental impact, including the search for new fungicide systems that comply with those rules. The fungicidal capacities of alternative compounds diiodomethyl p-tolylsulfone (DIMPTS), 3-iodo- 2-propynyl N-butylcarbamate (IPBC) and thiabendazole / 2-thiazol-4-yl-1H-benzo imidazole(TBZ) were compared to those of conventional fungicides, 2-(thiocyanomethylthio)-1,3-benzothiazole (TCMTB)and the mixture of phenolic compounds). This fungicidal capacity was evaluated against different strains of fungi in different processes. Fungicides were applied in the chrome tanning process, fatliquoring of hides tanned with vegetable extracts and a preservative pickling process. Further studies consisted of a microbiological control samples inoculated with fungi common in tannery, determination of the fungicide content on ...
Cells, Leishmania, Leishmania Donovani, Trypanosoma, Trypanosoma Brucei, Trypanosoma Brucei Rhodesiense, Trypanosoma Cruzi, Adenine, Amides, Nicotinamide, Nicotinamide Adenine Dinucleotide, Sulfonamides, Triazoles, Trypanosoma Brucei Brucei, Amines, Benzothiazoles, Chagas Disease, Disease, Parasite, Piperazines
Chemical compounds used to kill fungus include: Contents: 0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z See also References External links (3-ethoxypropyl)mercury bromide 2-methoxyethylmercury chloride 2-phenylphenol 8-hydroxyquinoline sulfate 8-phenylmercurioxyquinoline acibenzolar acylamino acid fungicides acypetacs aldimorph aliphatic nitrogen fungicides allyl alcohol amide fungicides ampropylfos anilazine anilide fungicides antibiotic fungicides aromatic fungicides aureofungin azaconazole azithiram azoxystrobin barium polysulfide benalaxyl benalaxyl-M benodanil benomyl benquinox bentaluron benthiavalicarb benzalkonium chloride benzamacril benzamide fungicides benzamorf benzanilide fungicides benzimidazole fungicides benzimidazole precursor fungicides benzimidazolylcarbamate fungicides benzohydroxamic acid benzothiazole fungicides bethoxazin binapacryl biphenyl bitertanol bithionol bixafen blasticidin-S Bordeaux mixture boric acid boscalid bridged diphenyl fungicides bromuconazole ...
Although Parkinsons disease is primarily considered to be a motor disorder, it has inarguable effects on cognition and personality. The cluster of neuropsychiatric sequelae known as impulse-control disorders has been of particular interest in recent years, perhaps owing to the potentially disastrous effects that such behaviors can have on individuals and families. Research has suggested that impulse control disorders are significantly more prevalent among individuals with Parkinsons disease, particularly with regards to pathological gambling and hypersexuality, and has further suggested that these disorders are significantly and substantively affected by the use of dopamine agonists. Treatment options for impulse control disorders tend to revolve around dopamine agonist dose reduction or cessation. The use of psychosocial strategies, or deep-brain stimulation of the subthalamic nucleus may also be considered in the management of patients with impulse control disorders ...
BACKGROUND: Natural and synthetic rubbers containing rubber accelerators are well-known causes of occupational skin disease. Allergic contact dermatitis caused by rubber gloves is frequent and has almost exclusively been attributed to contact sensitization to accelerators. OBJECTIVE: This study aimed to evaluate the frequency of rubber accelerators sensitization in the population living in northeastern Italy, to find time trend and a correlation with occupations, and to investigate co-sensitization between rubber accelerators. METHODS: A population of 23,774 subjects was patch tested in 6 cities in northeastern Italy in the years 1996 to 2012 using carba mix 3%, thiuram mix 1%, benzothiazole (MBT) mix 1%, and isopropyl phenyl paraphenylamine diamine (IPPD) mix 0.6%. RESULTS: The overall frequency of carbamates, MBT, thiurams, and IPPD mix sensitization was 3.4%, 0.65%, 1.75%, and 0.83%, respectively. On a logistic regression analysis (control group: white-collar workers), we found a ...
Objective Impulse control disorders are commonly associated with dopaminergic therapy in Parkinsons disease (PD). PD patients with impulse control disorders demonstrate enhanced dopamine release to conditioned cues and a gambling task on [11C]raclopride positron emission tomography (PET) imaging and enhanced ventral striatal activity to reward on functional MRI. We compared PD patients with impulse control disorders and age-matched and gender-matched controls without impulse control disorders using [123I]FP-CIT (2β-carbomethoxy-3β-(4-iodophenyl)tropane) single photon emission computed tomography (SPECT), to assess striatal dopamine transporter (DAT) density.. ...
View Notes - personality_disorders_and_impulse_control_disorders-post from PSC 49640 at UC Davis. Personality Disorders and Impulse Control Disorders Impulse Dr. Nolan Zane Dr. Personality disorders:

benzothiazole (CHEBI:45993)benzothiazole (CHEBI:45993)

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Biological Aspects of Emerging Benzothiazoles: A Short ReviewBiological Aspects of Emerging Benzothiazoles: A Short Review

Benzothiazole and benzoxazole derivatives," Journal of the American Chemical Society, vol. 75, no. 3, pp. 712-714, 1953. View ... C. Sheng, J. Zhu, W. Zhang et al., "3D-QSAR and molecular docking studies on benzothiazole derivatives as Candida albicans N- ... A. Rana, N. Siddiqui, S. A. Khan, S. E. Haque, and M. A. Bhat, "N-{[(6-Substituted-1,3-benzothiazole-2-yl)amino]carbonothioyl}- ... A. Ammazzalorso, A. Giancristofaro, A. DAngelo et al., "Benzothiazole-based N-(phenylsulfonyl)amides as a novel family of PPAR ...
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3PO1: Thrombin In Complex With Benzothiazole Guanidine3PO1: Thrombin In Complex With Benzothiazole Guanidine

THROMBIN HEAVY CHAINTHROMBIN LIGHT CHAINTHROMBIN PEPTIDEAcetate IonEthyl [(2z)-2-(Carbamimidoylimino)-6-Hydroxy-1,3-Benzothiazol-3(2h)-Yl]acetateSodium Ion
more infohttps://www.ncbi.nlm.nih.gov/Structure/pdb/3PO1

Benzothiazole, 5-chloro-2-methylBenzothiazole, 5-chloro-2-methyl

The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
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Benzothiazole - WikipediaBenzothiazole - Wikipedia

A derivative of benzothiazole is the light-emitting component of luciferin, found in fireflies. Benzothiazoles consist of a 5- ... Benzothiazole are prepared by treatment of 2-mercaptoaniline with acid chlorides: C6H4(NH2)SH + RC(O)Cl → C6H4(NH)SCR + HCl + ... Benzothiazole is an aromatic heterocyclic compound with the chemical formula C 7H 5NS. It is colorless, slightly viscous liquid ... Benzothiazoles are related to thiazoles, which lack the fused benzene ring. Benzoxazoles, which substitute an oxygen for the ...
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2-(Thiocyanomethylthio)benzothiazole 170082-(Thiocyanomethylthio)benzothiazole 17008

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Federal Register
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      2-(Thiocyanomethylthio)benzothiazole Risk Assessment; Notice of AvailabilityFederal Register :: 2-(Thiocyanomethylthio)benzothiazole Risk Assessment; Notice of Availability

... benzothiazole (TCMTB), and opens a public comment period on these documents. The public also is encouraged to suggest risk ... 2-(Thiocyanomethylthio)benzothiazole Risk Assessment; Notice of Availability. A Notice by the Environmental Protection Agency ... benzothiazole (TCMTB), and opens a public comment period on these documents. The public also is encouraged to suggest risk ...
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Benzothiazole-2-thiol - Substance Information - ECHABenzothiazole-2-thiol - Substance Information - ECHA

Benzothiazole-2-thiol. Translated names 18 CAS names 1 IUPAC names 9 Trade names 2 Other identifiers 9 ...
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Benzothiazole-2-thiol - Substance Information - ECHABenzothiazole-2-thiol - Substance Information - ECHA

Benzothiazole-2-thiol. Translated names 18 CAS names 1 IUPAC names 9 Trade names 2 Other identifiers 9 ...
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Biological Important Ni(II) Ternary Complexes Derived from 2-Substituted Benzothiazoles and Amino AcidsBiological Important Ni(II) Ternary Complexes Derived from 2-Substituted Benzothiazoles and Amino Acids

... benzothiazole (APBT) and L-L´ = 2-(2´-hydroxyphenyl)benzothiazole (HPBT), 2-(2´-mercaptophenyl)benzothiazole (MPBT) have been ... Biological Important Ni(II) Ternary Complexes Derived from 2-Substituted Benzothiazoles and Amino Acids. Narendra Pal, Mahesh ...
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Provisional Peer-Reviewed Toxicity Values for Benzothiazole | Risk Assessment Portal | US EPAProvisional Peer-Reviewed Toxicity Values for Benzothiazole | Risk Assessment Portal | US EPA

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3-Amino-2,1-benzothiazole-5-sulfonic acid | C7H6N2O3S2 - PubChem3-Amino-2,1-benzothiazole-5-sulfonic acid | C7H6N2O3S2 - PubChem

1-benzothiazole-5-sulfonic acid , C7H6N2O3S2 , CID 104612 - structure, chemical names, physical and chemical properties, ...
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Synthesis and anti-angiogenic activity of benzothiazole, benzimidazole containing phthalimide derivatives. | Sigma-AldrichSynthesis and anti-angiogenic activity of benzothiazole, benzimidazole containing phthalimide derivatives. | Sigma-Aldrich

Benzothiazole and benzimidazole containing phthalimide derivatives (NK037, NK041, NK042, NK0139A and NK0148) have been ... Synthesis and anti-angiogenic activity of benzothiazole, benzimidazole containing phthalimide derivatives.. [Shunmugam ...
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Molecules | Free Full-Text | Design and Synthesis of New Benzothiazole Compounds as Selective hMAO-B InhibitorsMolecules | Free Full-Text | Design and Synthesis of New Benzothiazole Compounds as Selective hMAO-B Inhibitors

In the current work a new class of novel benzothiazole-hydrazone derivatives was designed and synthesized as hMAO-B inhibitors ... Keywords: benzothiazole; hydrazone; MAO enzyme inhibition; docking study; cytotoxicity benzothiazole; hydrazone; MAO enzyme ... In the current work a new class of novel benzothiazole-hydrazone derivatives was designed and synthesized as hMAO-B inhibitors ... Design and Synthesis of New Benzothiazole Compounds as Selective hMAO-B Inhibitors. Sinem Ilgın 1. ...
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Molecules | Free Full-Text | Synthesis and in vitro Evaluation of New Benzothiazole Derivatives as Schistosomicidal AgentsMolecules | Free Full-Text | Synthesis and in vitro Evaluation of New Benzothiazole Derivatives as Schistosomicidal Agents

Keywords: Benzothiazole; dithiocarbamate; thiadiazole; thiosemicarbazones; schistosomicidal agents. Benzothiazole; ... Synthesis and in vitro Evaluation of New Benzothiazole Derivatives as Schistosomicidal Agents. Mona A Mahran 1,* , Samia ... Mahran, M.A.; William, S.; Ramzy, F.; Sembel, A.M. Synthesis and in vitro Evaluation of New Benzothiazole Derivatives as ... "Synthesis and in vitro Evaluation of New Benzothiazole Derivatives as Schistosomicidal Agents." Molecules 12, no. 3: 622-633. ...
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Visible light photoredox catalysis: conversion of a mixture of thiophenols and nitriles into 2-substituted benzothiazoles via...Visible light photoredox catalysis: conversion of a mixture of thiophenols and nitriles into 2-substituted benzothiazoles via...

... visible-light-mediated method for the construction of 2-substituted benzothiazoles from easily available thiophenols (2.0 equiv ... To the best of our knowledge, this is the first example of the synthesis of 2-substituted benzothiazoles through sequential C-S ... Visible light photoredox catalysis: conversion of a mixture of thiophenols and nitriles into 2-substituted benzothiazoles via ... Visible light photoredox catalysis: conversion of a mixture of thiophenols and nitriles into 2-substituted benzothiazoles via ...
more infohttp://pubs.rsc.org/en/content/articlelanding/2018/qo/c8qo00219c/unauth

Antitumor benzothiazoles. 26.(1) 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (GW 610, NSC 721648), a simple fluorinated 2...Antitumor benzothiazoles. 26.(1) 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (GW 610, NSC 721648), a simple fluorinated 2...

Antitumor benzothiazoles. 26.(1) 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (GW 610, NSC 721648), a simple fluorinated 2- ... Mechanistically, this new series of agents contrasts with the previously reported 2-(4-aminophenyl)benzothiazoles; compound 8n ... Synthesis of analogues substituted in the benzothiazole ring was achieved via the reaction of o-aminothiophenol disulfides with ...
more infohttps://www.sigmaaldrich.com/catalog/papers/16392802

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CAS No.49790-72-9,Benzothiazole, 2-[[(5-nitro-2-furanyl)methyl]thio]- SuppliersCAS No.49790-72-9,Benzothiazole, 2-[[(5-nitro-2-furanyl)methyl]thio]- Suppliers

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Benzothiazole derivatives, processes for their preparation and     pharmaceutical compositions containing these compounds -...Benzothiazole derivatives, processes for their preparation and pharmaceutical compositions containing these compounds -...

Benzothiazole derivatives corresponding to the general formula I ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 ... Benzothiazole derivatives corresponding to the general formula I ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 ... a) a benzothiazole derivative corresponding to the general formula II ##STR24## wherein R.sup.1 to R.sup.5 have the meanings ... b) a benzothiazole derivative corresponding to the general formula III ##STR25## wherein R.sup.1 to R.sup.4 have the meanings ...
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Benzothiazole, 4-nitro- (6CI,7CI,8CI,9CI) (CAS 2942-08-7) Market Research Report 2018Benzothiazole, 4-nitro- (6CI,7CI,8CI,9CI) (CAS 2942-08-7) Market Research Report 2018

The report generally describes benzothiazole, 4-nitro- (6ci,7ci,8ci,9ci), examines its uses, production methods, patents. ... Benzothiazole, 4-nitro- (6ci,7ci,8ci,9ci) prices in other regions. 7. BENZOTHIAZOLE, 4-NITRO- (6CI,7CI,8CI,9CI) END-USE SECTOR ... Benzothiazole, 4-nitro- (6ci,7ci,8ci,9ci) market forecast. 6. BENZOTHIAZOLE, 4-NITRO- (6CI,7CI,8CI,9CI) MARKET PRICES. 6.1. ... Benzothiazole, 4-nitro- (6ci,7ci,8ci,9ci) prices in Europe. 6.2. Benzothiazole, 4-nitro- (6ci,7ci,8ci,9ci) prices in Asia 6.3. ...
more infohttps://marketpublishers.com/report/industry/chemicals_petrochemicals/benzothiazole_4-nitro-_6ci_7ci_8ci_9ci_2942-08-7_market_research_report.html

6-Methoxy-1,3-benzothiazole-2-thiol (CAS 2182-73-2) Market Research Report 20186-Methoxy-1,3-benzothiazole-2-thiol (CAS 2182-73-2) Market Research Report 2018

3-benzothiazole-2-thiol (CAS 2182-73-2) Market Research Report 2018 aims at providing comprehensive data on 6-methoxy-1,3- ... 6-methoxy-1,3-benzothiazole-2-thiol prices in other regions. 7. 6-METHOXY-1,3-BENZOTHIAZOLE-2-THIOL END-USE SECTOR 7.1. 6- ... 6-methoxy-1,3-benzothiazole-2-thiol market forecast. 6. 6-METHOXY-1,3-BENZOTHIAZOLE-2-THIOL MARKET PRICES. 6.1. 6-methoxy-1,3- ... 6-methoxy-1,3-benzothiazole-2-thiol prices in Asia 6.3. 6-methoxy-1,3-benzothiazole-2-thiol prices in North America. 6.4. ...
more infohttps://marketpublishers.com/report/industry/chemicals_petrochemicals/2_3h_-benzothiazolethione_6-methoxy-_9ci_2182-73-2_market_research_report.html

Luminescent Ir(iii) complexes containing benzothiazole-based tridentate ligands: synthesis, characterization, and application...Luminescent Ir(iii) complexes containing benzothiazole-based tridentate ligands: synthesis, characterization, and application...

... complexes that contain benzothiazole-based tridentate ligands were synthesized and their crystal structures and luminescent ... benzothiazole. -based tridentate ligands. : synthesis, characterization, and application to organic light-emitting diodes J. ... benzothiazole. -based tridentate ligands. : synthesis, characterization, and application to organic light-emitting diodes ... benzothiazole. -based tridentate ligands. were synthesized and their crystal structures and luminescent properties were ...
more infohttp://pubs.rsc.org/en/Content/ArticleLanding/DT/2012/C1DT11560J

Chemical Summary for 1,2,4-Triazolo(3,4-b)benzothiazole-5-methanolChemical Summary for 1,2,4-Triazolo(3,4-b)benzothiazole-5-methanol

... from www.PesticideInfo.org. ... 1,2,4-Triazolo(3,4-b)benzothiazole-5-methanol; 124Triazolo34bbenzothiazole5methanol; 620201 [US EPA PC Code, Numeric ]; 620201 ... Identification and Use of 1,2,4-Triazolo(3,4-b)benzothiazole-5-methanol. ... Additional Information for 1,2,4-Triazolo(3,4-b)benzothiazole-5-methanol. ...
more infohttp://pesticideinfo.org/Summary_Chemical.jsp?Rec_Id=PRI38119
  • It is surprisingly found that the benzothiazole derivatives which may be used according to the invention have a powerful inhibitory action which in some cases is a highly selective action on the enzyme lipoxygenase at concentrations at whichcyclooxygenase is unaffected while some benzothiazole derivatives inhibit both enzymes, lipoxygenase and cyclooxygenase. (patentgenius.com)
  • Biological important ternary complexes of the type [NiCl(L-L) (A-A)(H 2 O)] and [Ni(L-L´)(A-A)(H 2 O) 2 ], where A-A = Glycine (Gly), Alanine (Ala), L-L = 2-(2´-aminophenyl)benzothiazole (APBT) and L-L´ = 2-(2´-hydroxyphenyl)benzothiazole (HPBT), 2-(2´-mercaptophenyl)benzothiazole (MPBT) have been synthesized. (hindawi.com)
  • Ir( III ) complexes that contain benzothiazole -based tridentate ligands were synthesized and their crystal structures and luminescent properties were examined. (rsc.org)
  • Objective: Coherence of biological activities of copper soaps and benzothiazole stimulated our interest to extend the studies in their cumulative form as complexes. (eurekaselect.com)
  • Control of neurodegenerative diseases with benzothiazole-benzamide derivatives CSIC has developed a group of heterocyclic compounds derived from a privileged structural nucleus with the capacity to inhibit the LRRK2 enzyme. (innoget.com)
  • Benzothiazole are important group of compounds reported to have various biological activities and hence the present study was undertaken in order to synthesize same new compounds built upon this nucleus with the hope to enhance the biological properties of newly designed compounds. (derpharmachemica.com)
  • Riluzole is in a class of medications called benzothiazoles. (medlineplus.gov)
  • In the present work 2-substituted benzothiazole (a) was prepared from p-tolnidine via cyclization reaction then N-2-benzothiazolyl thiourea was synthesized by reacting (a) with ammonium thiocyanate. (derpharmachemica.com)
  • The 'Global and Chinese Ethyl 2-bromo-1,3-benzothiazole-6-carboxylate Industry, 2012-2022 Market Research Report' is a professional and in-depth study on the current state of the global Ethyl 2-bromo-1,3-benzothiazole-6-carboxylate industry with a focus on the Chinese market. (reportsnreports.com)
  • The report provides key statistics on the market status of the Ethyl 2-bromo-1,3-benzothiazole-6-carboxylate manufacturers and is a valuable source of guidance and direction for companies and individuals interested in the industry.Firstly, the report provides a basic overview of the industry including its definition, applications and manufacturing technology. (reportsnreports.com)
  • Through the statistical analysis, the report depicts the global and Chinese total market of Ethyl 2-bromo-1,3-benzothiazole-6-carboxylate industry including capacity, production, production value, cost/profit, supply/demand and Chinese import/export. (reportsnreports.com)
  • The report then estimates 2017-2022 market development trends of Ethyl 2-bromo-1,3-benzothiazole-6-carboxylate industry. (reportsnreports.com)
  • In the end, the report makes some important proposals for a new project of Ethyl 2-bromo-1,3-benzothiazole-6-carboxylate Industry before evaluating its feasibility. (reportsnreports.com)
  • Overall, the report provides an in-depth insight of 2012-2022 global and Chinese Ethyl 2-bromo-1,3-benzothiazole-6-carboxylate industry covering all important parameters. (reportsnreports.com)
  • A set of benzimidazoles, 3 H -imidazo[4,5- b ]pyridines, purines, xanthines and benzothiazoles was readily prepared from (hetero)aromatic ortho -diamines or ortho -aminothiophenol and aldehydes using chlorotrimethylsilane in DMF as a promoter and water-acceptor agent, followed by oxidation with air oxygen. (enamine.net)
  • The Benzothiazole Alkaloids" Australian Journal of Chemistry 62(7) 639-647.doi:10.1071/CH09126 Hans-Wilhelm Engels, Herrmann-Josef Weidenhaupt, Manfred Pieroth, Werner Hofmann, Karl-Hans Menting, Thomas Mergenhagen, Ralf Schmoll, Stefan Uhrlandt "Rubber, 4. (wikipedia.org)
  • Belagali, S. 2016-01-29 00:00:00 Keywords Guanidinyl benzothiazole Antioxidant activity DPPH assay ABTS assay Antimicrobial Introduction One of the main aims of synthetic chemistry is the development of new antimicrobial therapeutic agents. (deepdyve.com)
  • The parent of the class of benzothiazoles. (ebi.ac.uk)
  • The cyclooxygenase and/or lipoxygenase inhibiting benzothiazole derivatives according to the invention may therefore be used asmedicaments for the treatment of inflammatory and allergic conditions. (patentgenius.com)
  • A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use. (molbase.com)