Cytochrome P-450 CYP1A1
A liver microsomal cytochrome P-450 monooxygenase capable of biotransforming xenobiotics such as polycyclic hydrocarbons and halogenated aromatic hydrocarbons into carcinogenic or mutagenic compounds. They have been found in mammals and fish. This enzyme, encoded by CYP1A1 gene, can be measured by using ethoxyresorufin as a substrate for the ethoxyresorufin O-deethylase activity.
Both the antioxidant and D3 agonist actions of pramipexole mediate its neuroprotective actions in mesencephalic cultures. (1/804)
Pramipexole (PPX) is a full intrinsic activity, direct-acting dopamine (DA) agonist possessing 7-fold higher affinity for D3 than for D2 receptors. It also is a potent antioxidant. PPX was previously shown to be neuroprotective because it dose dependently attenuated the DA neuron loss produced by levodopa in mesencephalic cultures. Several different drugs with properties similar to PPX were studied here to better understand the mechanism or mechanisms responsible for this neuroprotective effect. The D3-preferring agonist 7-hydroxy-diphenylaminotetralin (7-OH-DPAT) and the D3 antagonist U99194, respectively, increased and decreased the neuroprotective effects of PPX in a dose-dependent fashion. Addition of the selective D2 agonist U95666 or the D2/D3 antagonists domperidone or raclopride did not affect PPX's neuroprotective effect. Interestingly, 7-OH-DPAT by itself did not attenuate the DA neuron loss produced by levodopa. However, when 7-OH-DPAT was combined with a low dose of the antioxidants U101033E or alpha-tocopherol, the toxic effects of levodopa were attenuated. Similar results were observed when the D3-preferring agonist PD128, 907 was studied. In addition, media conditioned by exposure of mesencephalic cultures incubated with all D3-preferring agonists studied was shown to enhance the growth of DA neurons in freshly harvested recipient cultures implicating a D3-mediated trophic activity in the neuroprotective effect. These data suggest that PPX's neuroprotective actions in the levodopa toxicity model are a consequence of its combined actions as a D3 receptor agonist and an antioxidant. (+info)Aldose reductase functions as a detoxification system for lipid peroxidation products in vasculitis. (2/804)
Giant cell arteritis (GCA) is a systemic vasculitis preferentially affecting large and medium-sized arteries. Inflammatory infiltrates in the arterial wall induce luminal occlusion with subsequent ischemia and degradation of the elastic membranes, allowing aneurysm formation. To identify pathways relevant to the disease process, differential display-PCR was used. The enzyme aldose reductase (AR), which is implicated in the regulation of tissue osmolarity, was found to be upregulated in the arteritic lesions. Upregulated AR expression was limited to areas of tissue destruction in inflamed arteries, where it was detected in T cells, macrophages, and smooth muscle cells. The production of AR was highly correlated with the presence of 4-hydroxynonenal (HNE), a toxic aldehyde and downstream product of lipid peroxidation. In vitro exposure of mononuclear cells to HNE was sufficient to induce AR production. The in vivo relationship of AR and HNE was explored by treating human GCA temporal artery-severe combined immunodeficiency (SCID) mouse chimeras with the AR inhibitors Sorbinil and Zopolrestat. Inhibition of AR increased HNE adducts twofold and the number of apoptotic cells in the arterial wall threefold. These data demonstrate that AR has a tissue-protective function by preventing damage from lipid peroxidation. We propose that AR is an oxidative defense mechanism able to neutralize the toxic effects of lipid peroxidation and has a role in limiting the arterial wall injury mediated by reactive oxygen species. (+info)Efficacy, safety, and tolerance of the non-ergoline dopamine agonist pramipexole in the treatment of advanced Parkinson's disease: a double blind, placebo controlled, randomised, multicentre study. (3/804)
OBJECTIVES: Pramipexole, a non-ergot dopamine D2/D3 receptor agonist, was investigated as an add on drug in advanced parkinsonian patients with motor fluctuations to assess efficacy, safety, and tolerance. METHODS: Seventy eight patients of either sex with advanced Parkinson's disease and treatment complications such as motor fluctuations were enrolled into a double blind, placebo controlled, randomised, multicentre study (phase II) and assigned to add on treatment with pramipexole (n=34) versus placebo (n=44) to a previously stabilised antiparkinsonian medication (7 week dose titration interval, 4 week maintenance period). The primary end point of efficacy was the change from baseline in the total score of the unified Parkinson's disease rating scale (UPDRS) in the on "period" (2 hours after intake of study medication). Safety and tolerability were assessed on the basis of adverse events, vital signs, laboratory measurements, and ECG recordings. RESULTS: There was a significant improvement of the pramipexole group in UPDRS total scores, subscores part II, III (activities of daily living and motor examination), and IV (complications of therapy). Mean UPDRS total score decreased by 37.3% under pramipexole compared with 12.2% under placebo (p<0.001). Patients under pramipexole reported an overall reduction in "off" periods of 12%--resulting in 1.7 more hours "on" time a day--compared with an increase in "off" periods of 2% under placebo. There were no unexpected safety results. The adverse event profile disclosed a high tolerability. The most important adverse events under pramipexole were fatigue, dyskinesia, and vivid dreams. CONCLUSION: Pramipexole administration is an efficacious and well tolerated add on therapy in patients with advanced Parkinson's disease with an improvement in activities of daily living, motor function, and treatment associated complications. (+info)Primary active transport of organic anions on bile canalicular membrane in humans. (4/804)
Biliary excretion of several anionic compounds was examined by assessing their ATP-dependent uptake in bile canalicular membrane vesicles (CMV) prepared from six human liver samples. 2, 4-Dinitrophenyl-S-glutathione (DNP-SG), leukotriene C4 (LTC4), sulfobromophthalein glutathione (BSP-SG), E3040 glucuronide (E-glu), beta-estradiol 17-(beta-D-glucuronide) (E2-17G), grepafloxacin glucuronide (GPFXG), pravastatin, BQ-123, and methotrexate, which are known to be substrates for the rat canalicular multispecific organic anion transporter, and taurocholic acid (TCA), a substrate for the bile acid transporter, were used as substrates. ATP-dependent and saturable uptake of TCA, DNP-SG, LTC4, E-glu, E2-17G, and GPFXG was observed in all human CMV preparations examined, suggesting that these compounds are excreted in the bile via a primary active transport system in humans. Primary active transport of the other substrates was also seen in some of CMV preparations but was negligible in the others. The ATP-dependent uptake of all the compounds exhibited a large inter-CMV variation, and there was a significant correlation between the uptake of glutathione conjugates (DNP-SG, LTC4, and BSP-SG) and glucuronides (E-glu, E2-17G, and GPFXG). However, there was no significant correlation between TCA and the other organic anions, implying that the transporters for TCA and for organic anions are different also in humans. When the average value for the ATP-dependent uptake by each preparation of human CMVs was compared with that of rat CMVs, the uptake of glutathione conjugates and nonconjugated anions (pravastatin, BQ-123, and methotrexate) in humans was approximately 3- to 76-fold lower than that in rats, whereas the uptake of glucuronides was similar in the two species. Thus there is a species difference in the primary active transport of organic anions across the bile canalicular membrane that is less marked for glucuronides. (+info)Kinetic control of multiple forms of Ca(2+) spikes by inositol trisphosphate in pancreatic acinar cells. (5/804)
The mechanisms of agonist-induced Ca(2+) spikes have been investigated using a caged inositol 1,4,5-trisphosphate (IP(3)) and a low-affinity Ca(2+) indicator, BTC, in pancreatic acinar cells. Rapid photolysis of caged IP(3) was able to reproduce acetylcholine (ACh)-induced three forms of Ca(2+) spikes: local Ca(2+) spikes and submicromolar (<1 microM) and micromolar (1-15 microM) global Ca(2+) spikes (Ca(2+) waves). These observations indicate that subcellular gradients of IP(3) sensitivity underlie all forms of ACh-induced Ca(2+) spikes, and that the amplitude and extent of Ca(2+) spikes are determined by the concentration of IP(3). IP(3)-induced local Ca(2+) spikes exhibited similar time courses to those generated by ACh, supporting a role for Ca(2+)-induced Ca(2+) release in local Ca(2+) spikes. In contrast, IP(3)- induced global Ca(2+) spikes were consistently faster than those evoked with ACh at all concentrations of IP(3) and ACh, suggesting that production of IP(3) via phospholipase C was slow and limited the spread of the Ca(2+) spikes. Indeed, gradual photolysis of caged IP(3) reproduced ACh-induced slow Ca(2+) spikes. Thus, local and global Ca(2+) spikes involve distinct mechanisms, and the kinetics of global Ca(2+) spikes depends on that of IP(3) production particularly in those cells such as acinar cells where heterogeneity in IP(3) sensitivity plays critical role. (+info)Attenuation of ischemia induced increases in sodium and calcium by the aldose reductase inhibitor zopolrestat. (6/804)
OBJECTIVE: We have previously demonstrated that zopolrestat, an inhibitor of the enzyme aldose reductase, reduces ischemic injury in hearts from diabetic and non-diabetic rats. To further explore potential cardioprotective mechanisms of zopolrestat, we measured changes in intracellular sodium, calcium, and Na+,K(+)-ATPase activity in zopolrestat treated hearts during ischemia and reperfusion. METHODS: Hearts from acute diabetic (Type I) and age-matched control rats were isolated and retrogradely perfused. Hearts had either control perfusion or exposure to 1 microM zopolrestat for 10 min, followed by 20 min of global ischemia and 60 min of reperfusion. Changes in intracellular sodium and calcium were measured using 23Na and 19F magnetic resonance spectroscopy, respectively, while the activity of Na+,K(+)-ATPase was measured using biochemical assays. RESULTS: Zopolrestat blunted the rise in [Na]i during ischemia in both diabetic hearts and non-diabetic hearts. The end-ischemic [Na]i was 21.3 +/- 2.6 mM in the zopolrestat treated diabetics and 25.9 +/- 2.3 in zopolrestat treated non-diabetics, versus 31.6 +/- 2.6 mM and 32.9 +/- 2.8 mM in the untreated diabetics and untreated non-diabetics, respectively, (P = 0.002). Similarly, the rise in [Ca]i at the end of ischemia was significantly reduced in zopolrestat treated diabetic and non-diabetic hearts (P = 0.005). Zopolrestat increased the activity of Na-,K(+)-ATPase in diabetic hearts under baseline conditions (11.70 +/- 0.95 versus 7.28 +/- 0.98 mumol/h/mg protein, P = 0.005) as well as during ischemia and reperfusion. Similar changes in Na+,K(+)-ATPase activity were also observed in non-diabetic hearts. CONCLUSIONS: The data provide additional support to the protective effects of zopolrestat and suggest that a possible mechanism of action may be associated with the attenuation of the rise in [Na]i and [Ca]i during ischemia and reperfusion. (+info)Antioxidant activity: what do we measure? (7/804)
Inhibition of oxidation of 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) by free radicals generated by decomposition of 2,2'-azobis(2-amidopropane) (ABAP) by antioxidants and biological material was studied. A correlation was found between the ability of various substances to delay the onset of ABTS oxidation and their rapid reduction of the ABTS+* cation radical, and between the ability to reduce the maximal rate of ABTS oxidation and slow reduction of ABTS+*. The length of the lag period of ABTS oxidation was found to be independent of ABTS concentration. Similar decrease of peroxynitrite-induced ABTS+* formation by antioxidants was observed when the antioxidants were added before and after peroxynitrite. All these findings indicate that the main effect of antioxidants in this system is reduction of ABTS+* and not prevention of its formation. Reduction of oxidation products rather than inhibition of their formation may be the predominant mode of action of antioxidants in various assays of antioxidant activity. (+info)Malaria vectors in a traditional dry zone village in Sri Lanka. (8/804)
Malaria transmission by anopheline mosquitoes was studied in a traditional tank-irrigation-based rice-producing village in the malaria-endemic low country dry zone of northcentral Sri Lanka during the period August 1994-February 1997. Adult mosquitoes were collected from human and bovid bait catches, bovid-baited trap huts, indoor catches, and pit traps. Mosquito head-thoraces were tested for the presence of Plasmodium falciparum and P. vivax, and blood-engorged abdomens for the presence of human blood by ELISAs. House surveys were done at two-day intervals to record cases of blood film-confirmed malaria among the villagers. A total of 7,823 female anophelines representing 14 species were collected. Trends in anopheline abundance were significantly correlated with rainfall of the preceding month in An. annularis, An. barbirostris, An. subpictus, An. vagus, and An. varuna, but were not significant in An. culicifacies and An. peditaeniatus. Malaria parasite infections were seen in seven mosquito species, with 75% of the positive mosquitoes containing P. falciparum and 25% P. vivax. Polymorph PV247 was recorded from a vector (i.e., An. varuna) for the first time in Sri Lanka. Computations of mean number of infective vector (MIV) rates using abundance, circumsporozoite (CS) protein rate, and human blood index (HBI) showed the highest rate in An. culicifacies. A malaria outbreak occurred from October 1994 to January 1995 in which 45.5% of village residents experienced at least a single disease episode. Thereafter, malaria incidence remained low. Anopheles culicifacies abundance lagged by one month correlated positively with monthly malaria incidence during the outbreak period, and although this species ranked fifth in terms of abundance, infection was associated with a high MIV rate due to a high CS protein rate and HBI. Abundance trends in other species did not correlate significantly with malaria. It was concluded that An. culicifacies was epidemiologically the most important vector in the study area. (+info)
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Würfel, Hendryk; Jakobi, Dörthe (2018). "Syntheses of Substituted 2-Cyano-benzothiazoles". Organic Syntheses. 95: 177-191. doi: ...
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Rouf A, Tanyeli C (June 2015). "Bioactive thiazole and benzothiazole derivatives". European Journal of Medicinal Chemistry. 97 ...
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Thiazole
... s are found in a variety of specialized products, often fused with benzene derivatives, the so-called benzothiazoles. ... The following anthroquinone dyes contain benzothiazole subunits: Algol Yellow 8 (CAS# [6451-12-3]), Algol Yellow GC (CAS# [129- ... Other important thiazole derivatives are benzothiazoles, for example, the firefly chemical luciferin. Whereas thiazoles are ...
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The most popular example is the benzothiazole sulfone.[14] The reaction of the benzothiazole sulfone (1) with lithium ... It proceeds with the same mechanism as the benzothiazole sulfone above. The high E-selectivity of the Julia-Kocienski ... Since the benzothiazole variation of the Julia olefination does not involve equilibrating intermediates, the stereochemical ...
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The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
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CiteSeerX - SYNTHESIS, CHARACTERISATION AND ANTI-INFLAMMATORY ACTIVITY OF SOME 2-AMINO BENZOTHIAZOLE DERIVATIVES
Among the compounds tested three compounds Bt2 (5-chloro-1,3-benzothiazole-2-amine), Bt (6-methoxy-1,3-benzothiazole-2-amine) ... Key Words: Anti-inflammatory, bromine water, hind paw edema, benzothiazoles ... and Bt7 (6-methoxy-1,3-benzothiazole-2-amine)were the most active compounds in these series when compared with diclofenac ... methoxy substitution at 4 and 6-position in benzothiazole ring system showed better anti-inflammatory activity. ...
3-Amino-2,1-benzothiazole-5-sulfonic acid | C7H6N2O3S2 - PubChem
Benzotriazoles and Benzothiazoles Group - information sheet - Canada.ca
... address the potential for harm to Canadians and to the environment from the substances in the Benzotriazoles and Benzothiazoles ... For the benzothiazoles subgroup: *The IARC classified MBT as "probably carcinogenic to humans", and the health effect of ... Benzothiazoles subgroup. *Canadians may be exposed to these substances from drinking water, eating certain fish and seafood, ... Substances from the benzothiazoles subgroup, which are considered as precursors to MBT, may be released to the aquatic ...
Cas 21564-17-0,2-(Thiocyanatomethylthio)benzothiazole | lookchem
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Synthesis and anti-angiogenic activity of benzothiazole, benzimidazole containing phthalimide derivatives. | Sigma-Aldrich
Molecules | Free Full-Text | Design and Synthesis of New Benzothiazole Compounds as Selective hMAO-B Inhibitors
In the current work a new class of novel benzothiazole-hydrazone derivatives was designed and synthesized as hMAO-B inhibitors ... Keywords: benzothiazole; hydrazone; MAO enzyme inhibition; docking study; cytotoxicity benzothiazole; hydrazone; MAO enzyme ... In the current work a new class of novel benzothiazole-hydrazone derivatives was designed and synthesized as hMAO-B inhibitors ... Design and Synthesis of New Benzothiazole Compounds as Selective hMAO-B Inhibitors. Sinem Ilgın 1. ...
Molecules | Free Full-Text | Synthesis and in vitro Evaluation of New Benzothiazole Derivatives as Schistosomicidal Agents
Keywords: Benzothiazole; dithiocarbamate; thiadiazole; thiosemicarbazones; schistosomicidal agents. Benzothiazole; ... Synthesis and in vitro Evaluation of New Benzothiazole Derivatives as Schistosomicidal Agents. Mona A Mahran 1,* , Samia ... Mahran, M.A.; William, S.; Ramzy, F.; Sembel, A.M. Synthesis and in vitro Evaluation of New Benzothiazole Derivatives as ... "Synthesis and in vitro Evaluation of New Benzothiazole Derivatives as Schistosomicidal Agents." Molecules 12, no. 3: 622-633. ...
Efficient sodium bisulfite-catalyzed synthesis of benzothiazoles and their potential as ureases inhibitors - RSC Advances (RSC...
In this work we report the successful use of sodium bisulfite as catalyst for the synthesis of 19 benzothiazoles (BZTs) under ... In this work we report the successful use of sodium bisulfite as catalyst for the synthesis of 19 benzothiazoles (BZTs) under ... Efficient sodium bisulfite-catalyzed synthesis of benzothiazoles and their potential as ureases inhibitors† ... Efficient sodium bisulfite-catalyzed synthesis of benzothiazoles and their potential as ureases inhibitors D. Pereira Araujo, V ...
Benzotriazoles and benzothiazoles in human urine from several countries: a perspective on occurrence, biotransformation, and...
... and benzothiazole (BTH) derivatives are high-production-volume chemicals that are mainly used as corrosion inhibitors, and are ... benzothiazole, 2-morpholin-4-yl-benzothiazole, 2-hydroxy-benzothiazole, 2-methylthio-benzothiazole, 2-amino-benzothiazole, and ... 2-hydroxy-benzothiazole; 2-methylthio-benzothiazole; 2-morpholin-4-yl-benzothiazole; 2-thiocyanomethylthio-benzothiazole; 4-Me- ... Benzotriazole (BTR) and benzothiazole (BTH) derivatives are high-production-volume chemicals that are mainly used as corrosion ...
Visible light photoredox catalysis: conversion of a mixture of thiophenols and nitriles into 2-substituted benzothiazoles via...
... visible-light-mediated method for the construction of 2-substituted benzothiazoles from easily available thiophenols (2.0 equiv ... To the best of our knowledge, this is the first example of the synthesis of 2-substituted benzothiazoles through sequential C-S ... Visible light photoredox catalysis: conversion of a mixture of thiophenols and nitriles into 2-substituted benzothiazoles via ... Visible light photoredox catalysis: conversion of a mixture of thiophenols and nitriles into 2-substituted benzothiazoles via ...
Synthesis, Molecular Docking, DNA Binding and Anticancer Studies of Transition Metal Complex of N'-[Phenylmethylidene]-1,3...
3-benzothiazole-2-carbohydrazone (PMBC) and its Cu(II), Ni(II), Co(II) and Zn(II) metal complexes. The quantum chemical ... 3-Benzothiazole-2-Carbohydrazone. Proceedings of International Conference on Drug Discovery (ICDD) 2020 ... 3-Benzothiazole-2-Carbohydrazone (February 1, 2020). Proceedings of International Conference on Drug Discovery (ICDD) 2020, ...
Cas 99972-98-2,Benzothiazole, 4-methyl-2-(2-propynylthio)- (6CI) | lookchem
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Benzothiazole | 95-16-9
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6-Bromo-2-hydrazino-benzothiazole, 37390-63-9, suppliers and manufacturers
Find manufacturers and suppliers for 6-Bromo-2-hydrazino-benzothiazole, 37390-63-9. Synonyms: (6-Bromo-benzothiazol-2-yl)- ... 6-Bromo-benzothiazol-2-yl)-hydrazine; 6-bromo-2-hydrazino-1,3-benzothiazole; benzothiazole, 6-bromo-2-hydrazino- ... hydrazine; 6-bromo-2-hydrazino-1,3-benzothiazole; benzothiazole, 6-bromo-2-hydrazino- ...
Anticonvulsant and Neurological Profile of Benzothiazoles: A Mini-Review | Bentham Science
Benzothiazole molecule has a heterocyclic structure, basic in nature with wide variety of active sites. As a small molecule, it ... Benzothiazole molecule has a heterocyclic structure, basic in nature with wide variety of active sites. As a small molecule, it ... Benzothiazole derivatives were found to exhibit efficacy against some very serious diseases like cancer, neurodegeneration, ... Benzothiazole derivatives were found to exhibit efficacy against some very serious diseases like cancer, neurodegeneration, ...
Benzothiazole derivatives, processes for their preparation and pharmaceutical compositions containing these compounds -...
Benzothiazole derivatives corresponding to the general formula I ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 ... Benzothiazole derivatives corresponding to the general formula I ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 ... a) a benzothiazole derivative corresponding to the general formula II ##STR24## wherein R.sup.1 to R.sup.5 have the meanings ... b) a benzothiazole derivative corresponding to the general formula III ##STR25## wherein R.sup.1 to R.sup.4 have the meanings ...
ABSTRACTCompoundsDerivativeInhibitorsSulfenamideBiologically activeSulfonamideEvaluationBenzimidazole and benzothiazoleBenzimidazoles and benzothiazolesSelectiveNovel benzothiazoleSchiff BasesSubstancesPhenylCyclizationMoleculeChemistryPotentHeterocyclic compoundCorrosionAmino AcidsPhthalimideAcceleratorsInventionCompoundAromaticSuppliersSulfurActivityDCBSBenzene
ABSTRACT2
- ABSTRACT: A series of some novel 2-amino benzothiazole derivatives were synthesized and evaluated for anti-inflammatory activity. (psu.edu)
- abstract = "A new benzothiazole linked nanoporous polymer, imine benzothiazole polymer (IBTP), was synthesized via a Schiff base condensation reaction. (elsevier.com)
Compounds12
- Among the compounds tested three compounds Bt2 (5-chloro-1,3-benzothiazole-2-amine), Bt (6-methoxy-1,3-benzothiazole-2-amine) and Bt7 (6-methoxy-1,3-benzothiazole-2-amine)were the most active compounds in these series when compared with diclofenac sodium. (psu.edu)
- The MBT moiety was identified as the key part of the molecule in the benzothiazoles subgroup, which may be released to the Canadian environment based either on direct use and release of MBT, or through indirect release due to break down of the parent compounds. (canada.ca)
- Benzothiazole and its derivative are recognized as the most important heterocyclic compounds. (chemicalbook.com)
- This invention relates to new benzothiazole derivatives, a process fortheir preparation, their use as pharmaceutical preparations, in particular their use as lipoxygenase inhibitors and cyclooxygenase inhibitors, pharmaceutical preparations containing these compounds, and their preparation. (patentgenius.com)
- Control of neurodegenerative diseases with benzothiazole-benzamide derivatives CSIC has developed a group of heterocyclic compounds derived from a privileged structural nucleus with the capacity to inhibit the LRRK2 enzyme. (innoget.com)
- Background: Benzimidazole and benzothiazole subunits exist in many biologically active molecules, natural products, and synthetic compounds. (eurekaselect.com)
- Mahmood, Z., Ahmad, A. Synthesis of Some Heterocyclic Compounds Derived From 2-Amino Benzothiazole. (iraqjournals.com)
- Also from the reaction of (2-amino benzothiazole) with phthalic anhydride or malic anhydride attended compounds (8) and (9) ,respectively. (iraqjournals.com)
- This invention provides benzothiazole derivative compounds, compositions comprising such compounds, methods of preparing such compounds, and methods of using such compounds for detecting amyloid deposit(s) and for diagnosing a disease, disorder or condition characterized by amyloid deposit(s). (rpxcorp.com)
- Compared with known corrosion inhibitors based on benzothiazole derivatives, the compounds are distinguished by a lower water absorption, by chemical inertness and by a high stability to heat. (justia.com)
- Benzothiazole are important group of compounds reported to have various biological activities and hence the present study was undertaken in order to synthesize same new compounds built upon this nucleus with the hope to enhance the biological properties of newly designed compounds. (derpharmachemica.com)
- A set of 30 new compounds of 2-[(6-substituted benzothiazol-2-yl) amino]-2-oxoethyl 4-substituted piperazine-1-carbodithioate derivatives were synthesized by reacting 2-chloro-N -(6-substituted benzothiazole-2-yl) acetamide derivatives derivatives and sodium salts of appropriate N,N-disubstituted dithiocarbamic acids in ace-tone. (ogu.edu.tr)
Derivative5
- Firefly luciferin can be considered a derivative of benzothiazole. (wikipedia.org)
- A benzothiazole derivative is suggested as a dye for arsenic detection. (wikipedia.org)
- The broad spectrum of pharmacological activity in individual benzothiazole derivative enables it to serve as unique and valuable scaffolds for experimental drug design. (chemicalbook.com)
- Benzothiazole derivative (BD): [N-(3-(benzothiazol- 2-yl) phenyl)-1H-pyrazole-3-carboxamide] was tested for excretion of total sterols of high-fat diet fed C57BL/6J mice in view of lipid metabolism. (atlantis-press.com)
- Docking studies with the benzothiazole derivative 1 into the crystal structure of human 11beta-HSD1 revealed how the molecule may interact with the enzyme and cofactor. (ox.ac.uk)
Inhibitors11
- Benzothiazole-containing hydroxamic acids as histone deacetylase inhibitors and antitumor agents," Bioorganic and Medicinal Chemistry Letters , vol. 21, no. 24, pp. 7509-7512, 2011. (hindawi.com)
- 3D-QSAR and molecular docking studies on benzothiazole derivatives as Candida albicans N -myristoyltransferase inhibitors," European Journal of Medicinal Chemistry , vol. 42, no. 4, pp. 477-486, 2007. (hindawi.com)
- In the current work a new class of novel benzothiazole-hydrazone derivatives was designed and synthesized as h MAO-B inhibitors. (mdpi.com)
- Benzotriazole (BTR) and benzothiazole (BTH) derivatives are high-production-volume chemicals that are mainly used as corrosion inhibitors, and are widely distributed in the environment. (nih.gov)
- Evaluation of the benzothiazole aggregation inhibitors riluzole and PGL-135 as therapeutics for Huntington's disease. (semanticscholar.org)
- Synthesis and Evaluation of Benzothiazole-Based Analogues as Novel, Potent, and Selective Fatty Acid Amide Hydrolase Inhibitors. (medchemexpress.com)
- The present invention relates to 2-amino-benzothiazole sulfonamides, their use as broadspectrum HIV protease inhibitors, processes for their preparation as well as pharmaceutical compositions and diagnostic kits comprising them. (allindianpatents.com)
- The invention relates to phenolic derivatives of benzothiazole and to their use as corrosion inhibitors in organic materials, especially coating materials and lubricants. (justia.com)
- Various derivatives of mercaptobenzothiazole have also already been suggested as corrosion inhibitors, for example the benzothiazole-2-ylthiocarboxylic acids and their salts which are described in EP-A 129,506. (justia.com)
- It has now been found that certain benzothiazole derivatives containing hydrophobic groups can also be excellent corrosion inhibitors. (justia.com)
- Benzothiazole derivatives as novel inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1. (ox.ac.uk)
Sulfenamide9
- N-Cyclohexyl-2-benzothiazole sulfenamide ACGIH TLV None Listed OSHA PEL None Listed Respiratory Appropriate respiratory protection shall be worn when applied engineering controls are not adequate to protect against inhalation exposure. (schilderoord.nl)
- 3/10/2007 · N-cyclohexyl-2-benzothiazole sulfenamide Results in the Carcinogenic Potency Database N-Cyclohexyl-2-benzothiazole sulfenamide (CAS 95-33-0) SMILES, InChI and Structure are below. (promoworx.co.za)
- The n-cyclohexyl -2- benzothiazole Sulfenamide market is disintegrating and is highly competitive owing to the presence of major players and regional players. (promoworx.co.za)
- Accelerator CBS(CZ),N-Cyclohexyl-2-benzothiazole sulfenamide---Rongcheng Chemical General Factory Co., Ltd. (promoworx.co.za)
- China Accelerator CBS for Synthetic Rubber CAS 95-33-0 N-Cyclohexyl-2-Benzothiazole Sulfenamide, Find details about China Accelerator CBS, Zinc 2-Mercaptobenzothiazole from Accelerator CBS for Synthetic Rubber CAS 95-33-0 N-Cyclohexyl-2-Benzothiazole Sulfenamide Hainan Zhongxin Chemical Co., Ltd. (holebiwest.be)
- China Accelerator CBS for Synthetic Rubber CAS 95-33-0 N. Accelerator CBS, Zinc 2-Mercaptobenzothiazole, CAS No.: 155-04-4 manufacturer / supplier in China, offering Accelerator CBS for Synthetic Rubber CAS 95-33-0 N-Cyclohexyl-2-Benzothiazole Sulfenamide, Citrus Bioflavonoids Extract Hesperidin, Ethyl Vitamin C Ascorbic Acid CAS: 86404-04-8 and so on. (holebiwest.be)
- Rubber Accelerator Dcbs Dz,Rubber Accelerator Dcbs Dz,Chemical Auxiliary Agent,4979-32-2,N.n-dicyclohexyl-2-benzothiazole Sulfenamide from Plastic Auxiliary Agents Supplier or Manufacturer-Dalian Richon Chem Co., Ltd. (holebiwest.be)
- DCBS N-Cyclohexyl Benzothiazole Sulfenamide N,N- DICYCLOHEX YL-2- BENZOTHIAZ OLESULFENA MIDE 4979-32- 2 Vulkacit DZ Santocure DCBS Durax Accelerator DCBS Accicure DCS Akrochem PMC Chemicals Ltd 11. (holebiwest.be)
- Dcbs, Dcbs (DZ), N N-Dicyclohexyl-2-Benzothiazole Sulfenamide manufacturer / supplier in China, offering Export Grade Rubber Accelerator Dcbs (DZ) CAS No.: 4979-32-2, White Powder 99.6% Feed Grade Ammonium Chloride, Citric Acid Anhydrous HS: 2918140000 and so on. (holebiwest.be)
Biologically active1
- An easy synthetic protocol for the synthesis of biologically active benzimidazole, benzothiazole and benzoxazole derivatives has been demonstrated using a hybrid crystal NH 3 (CH 2 ) 4 NH 3 SiF 6 as a mild and efficient heterogeneous catalyst. (figshare.com)
Sulfonamide1
- N-cyclohexyl-1,3-benzothiazole-2-sulfonamide State SOLID (MINERAL OIL MULL) Instrument Not specified, most likely a prism, grating, or hybrid spectrometer. (promoworx.co.za)
Evaluation5
- Synthesis, structure-activity relationships and preliminary antitumor evaluation of benzothiazole-2-thiol derivatives as novel apoptosis inducers," Bioorganic and Medicinal Chemistry Letters , vol. 21, no. 4, pp. 1097-1101, 2011. (hindawi.com)
- Synthesis of benzothiazole derivatives and their biological evaluation as anticancer agents," Medicinal Chemistry Research , vol. 21, pp. 2644-2651, 2012. (hindawi.com)
- S. Gilani, K. Nagarajan, S. P. Dixit, M. Taleuzzaman, and S. A. Khan, "Benzothiazole incorporated thiazolidin-4-ones and azetidin-2-ones derivatives: synthesis and in vitro antimicrobial evaluation," Arabian Journal of Medicinal Chemistry , 2012. (hindawi.com)
- Sembel, A.M. Synthesis and in vitro Evaluation of New Benzothiazole Derivatives as Schistosomicidal Agents. (mdpi.com)
- Mahran MA, William S, Ramzy F, Sembel AM. Synthesis and in vitro Evaluation of New Benzothiazole Derivatives as Schistosomicidal Agents. (mdpi.com)
Benzimidazole and benzothiazole3
- New convenient conditions for benzimidazole and benzothiazole syntheses are described. (enamine.net)
- Methods: 2-Substituted benzimidazole and benzothiazole derivatives have been synthesized by the condensation of 1,2-phenylenediamine or 2-aminobenzothiophenol with 5-arylidenepyrimidine-2,4,6-(1H,3H, 5H)-trione derivatives via cleavage of C-C double bond without using a catalyst in EtOH under reflux conditions. (eurekaselect.com)
- Results: We report here a very simple, novel, efficient, and catalyst-free method for the synthesis of benzimidazole and benzothiazole in good to excellent yields from the treatment of 1,2-phenylenediamine and 2-aminothiophenol with various 5-arylidenepyrimidine-2,4,6(1H,3H,5H)-trione, respectively. (eurekaselect.com)
Benzimidazoles and benzothiazoles1
- Conclusion: This method appears to be general for the synthesis of benzimidazoles and benzothiazoles using 5-arylidenepyrimidine-2,4,6-(1H,3H,5H)-trione derivatives containing various aromatic and heteroaromatic aldehydes such as furfural and thiophene-2-carbaldehyde with electron-withdrawing and electron-releasing groups. (eurekaselect.com)
Selective2
- It is surprisingly found that the benzothiazole derivatives which may be used according to the invention have a powerful inhibitory action which in some cases is a highly selective action on the enzyme lipoxygenase at concentrations at whichcyclooxygenase is unaffected while some benzothiazole derivatives inhibit both enzymes, lipoxygenase and cyclooxygenase. (patentgenius.com)
- Part 20:3′-Cyano and 3′-Alkynyl-substituted 2-(4′-Aminophenyl)benzothiazoles as new potent and selective analogues. (springer.com)
Novel benzothiazole1
- Here, we report the discovery and synthesis of a series of novel benzothiazole derivatives and their inhibitory activities against 11beta-HSD1 from human hepatic microsomes measured using a radioimmunoassay (RIA) method. (ox.ac.uk)
Schiff Bases1
- Novel ruthenium(II/III) complexes of Schiff bases containing benzimidazole (bz) or benzothiazole (bs) moieties were isolated: the diamagnetic ruthenium complex, cis-[RuIICl2(bzpy)(PPh3)2] (1) was formed from the 1:1 M reaction between N-((pyridine-2-yl)methylene)-1H-benzimidazole (bzpy) and metal precursor, trans-[RuCl2(PPh3)3]. (edu.ng)
Substances7
- As a result of the draft screening assessment, the Government is proposing that 2-mercaptobenzothiazole (MBT) and its precursors, including the six substances in the benzothiazoles subgroup, may be harmful to the environment due to their releases from the sectors of concern identified in the draft screening assessment. (canada.ca)
- In addition, the Government is proposing that the 15 substances in the Benzotriazoles and Benzothiazoles Group are not harmful to human health at current levels of exposure. (canada.ca)
- Although the six substances in the Benzothiazoles subgroup are associated with health effects of concern, the risk to human health is low at levels of exposure considered in the assessment. (canada.ca)
- The screening assessment focuses on 15 of 17 substances referred to collectively as the Benzotriazoles and Benzothiazoles Group under the Chemicals Management Plan (CMP). (canada.ca)
- Substances in the benzotriazoles subgroup are not expected to occur naturally in the environment, while the natural occurrence of substances in the benzothiazoles subgroup is expected to be rare. (canada.ca)
- Substances in the benzothiazoles subgroup have major uses in automotive products, rubber products, lubricants and greases, and mining. (canada.ca)
- Substances from the benzothiazoles subgroup, which are considered as precursors to MBT, may be released to the aquatic environment primarily from tire and other rubber products manufacturing, use in metalworking fluids, and use in some subsectors of the mining industry. (canada.ca)
Phenyl2
- Synthesis of novel 2-[4-(4-substitutedbenzamido/phenylacetamido)phenyl]benzothiazoles as antimicrobial agents," Medicinal Chemistry Research , vol. 21, no. 11, pp. 3818-3825, 2012. (hindawi.com)
- In the SAR study, the phenyl ring substituted with chloro at 5 position, methoxy substitution at 4 and 6-position in benzothiazole ring system showed better anti-inflammatory activity. (psu.edu)
Cyclization2
- Synthesis and cyclization of benzothiazole. (chemicalbook.com)
- In the present work 2-substituted benzothiazole (a) was prepared from p-tolnidine via cyclization reaction then N-2-benzothiazolyl thiourea was synthesized by reacting (a) with ammonium thiocyanate. (derpharmachemica.com)
Molecule1
- Benzothiazole molecule has a heterocyclic structure, basic in nature with wide variety of active sites. (eurekaselect.com)
Chemistry6
- Synthesis, X-ray crystallographic analysis, and antitumor activity of N -(benzothiazole-2-yl)-1-(fluorophenyl)- O , O -dialkyl- α -aminophosphonates," Bioorganic and Medicinal Chemistry Letters , vol. 16, no. 6, pp. 1537-1543, 2006. (hindawi.com)
- Synthesis and anti-cancer activity of benzothiazole containing phthalimide on human carcinoma cell lines," Bioorganic and Medicinal Chemistry , vol. 16, no. 7, pp. 3626-3631, 2008. (hindawi.com)
- Synthesis and antimicrobial activity of novel 2-substituted benzimidazole, benzoxazole and benzothiazole derivatives," Arabian Journal of Chemistry , 2012. (hindawi.com)
- A comprehensive review in current developments of benzothiazole-based molecules in medicinal chemistry. (chemicalbook.com)
- Jagbir Gagoria, Prabhakar Kumar Verma and Anurag Khatkar, "Anticonvulsant and Neurological Profile of Benzothiazoles: A Mini-Review", Central Nervous System Agents in Medicinal Chemistry (2015) 15: 11. (eurekaselect.com)
- Belagali, S. 2016-01-29 00:00:00 Keywords Guanidinyl benzothiazole Antioxidant activity DPPH assay ABTS assay Antimicrobial Introduction One of the main aims of synthetic chemistry is the development of new antimicrobial therapeutic agents. (deepdyve.com)
Potent1
- FAAH inhibitor 1 (Benzothiazole analog 3) is a potent fatty acid amide hydrolase (FAAH) inhibitor with an IC 50 of 18±8 nM. (medchemexpress.com)
Heterocyclic compound1
- Benzothiazole is an aromatic heterocyclic compound with the chemical formula C 7H 5NS. (wikipedia.org)
Corrosion1
- Pulse radiolysis study of 2-Mercapto-benzothiazole-a corrosion inhibitor Mahal, H. (deepdyve.com)
Amino Acids1
- The reaction, which is performed under mild conditions, can be used as a deprotection method for cleavage of benzothiazole-2-sulfonyl-protected amino acids. (ru.nl)
Phthalimide2
- Synthesis and anti-angiogenic activity of benzothiazole, benzimidazole containing phthalimide derivatives. (sigmaaldrich.com)
- Benzothiazole and benzimidazole containing phthalimide derivatives (NK037, NK041, NK042, NK0139A and NK0148) have been synthesized and their anti-angiogenic activity was evaluated using ex vivo egg yolk angiogenesis model. (sigmaaldrich.com)
Accelerators1
- Accelerators contain sulfur and nitrogen like derivatives of benzothiazole and thiocarbanilides. (holebiwest.be)
Invention1
- The cyclooxygenase and/or lipoxygenase inhibiting benzothiazole derivatives according to the invention may therefore be used asmedicaments for the treatment of inflammatory and allergic conditions. (patentgenius.com)
Compound2
- Although the parent compound, benzothiazole is not widely used, many of its derivatives are found in commercial products or in nature. (wikipedia.org)
- The N-(1,3-benzothiazol-2-yl)-2-chloro acetamide compound(1) was prepared from the reaction of the compound (2-amino benzothiazole) with chloroacetyl chloride. (iraqjournals.com)
Aromatic1
- A set of benzimidazoles, 3 H -imidazo[4,5- b ]pyridines, purines, xanthines and benzothiazoles was readily prepared from (hetero)aromatic ortho -diamines or ortho -aminothiophenol and aldehydes using chlorotrimethylsilane in DMF as a promoter and water-acceptor agent, followed by oxidation with air oxygen. (enamine.net)
Suppliers4
- benzothiazole, 4-nitro- (6ci,7ci,8ci,9ci) manufacturers and suppliers with contacts and product range are mentioned in the study. (marketpublishers.com)
- It captures 6-methoxy-1,3-benzothiazole-2-thiol market trends, pays close attention to 6-methoxy-1,3-benzothiazole-2-thiol manufacturers and names suppliers. (marketpublishers.com)
- 5 benzothiazole uses products are offered for sale by suppliers on Alibaba A wide variety of benzothiazole uses options are available to you, There are 5 suppliers who sells benzothiazole uses on Alibaba, mainly located in Asia. (holebiwest.be)
- The top countries of suppliers are China, India, from which the percentage of benzothiazole uses supply is 60%, 40% respectively. (holebiwest.be)
Sulfur1
- Benzothiazole-2-sulfonamides react with an excess of hydroxylamine in aqueous solutions to form 2-hydroxybenzothiazole, sulfur dioxide, and the corresponding amine. (ru.nl)
Activity1
- Guanidinyl benzothiazole derivatives: Synthesis and structure activity relationship studies of a. (deepdyve.com)
DCBS1
- Accelerator DCBS(DZ),N,N'-Dicyclohexyl-2-benzothiazole. (holebiwest.be)
Benzene2
- Benzothiazoles consist of a 5-membered 1,3-thiazole ring fused to a benzene ring. (wikipedia.org)
- Benzothiazoles are related to thiazoles, which lack the fused benzene ring. (wikipedia.org)