Benzene rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.
A quinone fungicide used for treatment of seeds and foliage.
Saturated azacyclopropane compounds. They include compounds with substitutions on CARBON or NITROGEN atoms.
Hydrocarbon rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.
A lipid-soluble benzoquinone which is involved in ELECTRON TRANSPORT in mitochondrial preparations. The compound occurs in the majority of aerobic organisms, from bacteria to higher plants and animals.
LACTAMS forming compounds with a ring size of approximately 1-3 dozen atoms.
Toxic, volatile, flammable liquid hydrocarbon byproduct of coal distillation. It is used as an industrial solvent in paints, varnishes, lacquer thinners, gasoline, etc. Benzene causes central nervous system damage acutely and bone marrow damage chronically and is carcinogenic. It was formerly used as parasiticide.
A flavoprotein that reversibly catalyzes the oxidation of NADH or NADPH by various quinones and oxidation-reduction dyes. The enzyme is inhibited by dicoumarol, capsaicin, and caffeine.
A class of Arthropoda that includes SPIDERS; TICKS; MITES; and SCORPIONS.
Unsaturated azacyclopropane compounds that are three-membered heterocycles of a nitrogen and two carbon atoms.
An experimental lymphocytic leukemia of mice.
Alkylating antineoplastic agent used mainly for ovarian tumors. It is toxic to skin, gastrointestinal tract, bone marrow and kidneys.
Compounds consisting of benzene rings linked to each other in either ortho, meta or para positions. Permitted are any substitutions, but ring fusion to any of the benzene rings is not allowed.
A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients.
Alkylating anti-neoplastic agent.
A class of MOLECULAR CHAPERONES whose members act in the mechanism of SIGNAL TRANSDUCTION by STEROID RECEPTORS.
A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).
Synthetic organic reactions that use reactions between unsaturated molecules to form cyclical products.
NAD(P)H:(quinone acceptor) oxidoreductases. A family that includes three enzymes which are distinguished by their sensitivity to various inhibitors. EC 1.6.99.2 (NAD(P)H DEHYDROGENASE (QUINONE);) is a flavoprotein which reduces various quinones in the presence of NADH or NADPH and is inhibited by dicoumarol. EC 1.6.99.5 (NADH dehydrogenase (quinone)) requires NADH, is inhibited by AMP and 2,4-dinitrophenol but not by dicoumarol or folic acid derivatives. EC 1.6.99.6 (NADPH dehydrogenase (quinone)) requires NADPH and is inhibited by dicoumarol and folic acid derivatives but not by 2,4-dinitrophenol.
An oral anticoagulant that interferes with the metabolism of vitamin K. It is also used in biochemical experiments as an inhibitor of reductases.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
Metals that constitute the group 2 (formerly group IIa) of the periodic table.
A phylum of fungi that produce their sexual spores (basidiospores) on the outside of the basidium. It includes forms commonly known as mushrooms, boletes, puffballs, earthstars, stinkhorns, bird's-nest fungi, jelly fungi, bracket or shelf fungi, and rust and smut fungi.
A plant genus of the family POACEAE. The grain is used for FOOD and for ANIMAL FEED. This should not be confused with KAFFIR LIME or with KEFIR milk product.
Naphthalene rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.
A family of bracket fungi, order POLYPORALES, living in decaying plant matter and timber.
Six-carbon alicyclic hydrocarbons.
The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
The covalent bonding of an alkyl group to an organic compound. It can occur by a simple addition reaction or by substitution of another functional group.
A species of gram-positive, spherical bacteria whose organisms occur in tetrads and in irregular clusters of tetrads. The primary habitat is mammalian skin.
A group of 1,2-benzenediols that contain the general formula R-C6H5O2.
A flavoprotein oxidase complex that contains iron-sulfur centers. It catalyzes the oxidation of SUCCINATE to fumarate and couples the reaction to the reduction of UBIQUINONE to ubiquinol.
An alkylating sulfhydryl reagent. Its actions are similar to those of iodoacetate.
A flavoprotein containing oxidoreductase that catalyzes the dehydrogenation of SUCCINATE to fumarate. In most eukaryotic organisms this enzyme is a component of mitochondrial electron transport complex II.
The class of all enzymes catalyzing oxidoreduction reactions. The substrate that is oxidized is regarded as a hydrogen donor. The systematic name is based on donor:acceptor oxidoreductase. The recommended name will be dehydrogenase, wherever this is possible; as an alternative, reductase can be used. Oxidase is only used in cases where O2 is the acceptor. (Enzyme Nomenclature, 1992, p9)
The art or process of comparing photometrically the relative intensities of the light in different parts of the spectrum.
Benzene derivatives that include one or more hydroxyl groups attached to the ring structure.
An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.
A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.
Large enzyme complexes composed of a number of component enzymes that are found in STREPTOMYCES which biosynthesize MACROLIDES and other polyketides.
Highly reactive chemicals that introduce alkyl radicals into biologically active molecules and thereby prevent their proper functioning. Many are used as antineoplastic agents, but most are very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. They have also been used as components in poison gases.
The rate dynamics in chemical or physical systems.
The process by which ELECTRONS are transported from a reduced substrate to molecular OXYGEN. (From Bennington, Saunders Dictionary and Encyclopedia of Laboratory Medicine and Technology, 1984, p270)
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).
Substances that inhibit or prevent the proliferation of NEOPLASMS.
Highly reactive molecules with an unsatisfied electron valence pair. Free radicals are produced in both normal and pathological processes. They are proven or suspected agents of tissue damage in a wide variety of circumstances including radiation, damage from environment chemicals, and aging. Natural and pharmacological prevention of free radical damage is being actively investigated.
Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
Determination of the spectra of ultraviolet absorption by specific molecules in gases or liquids, for example Cl2, SO2, NO2, CS2, ozone, mercury vapor, and various unsaturated compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A transferase that catalyzes the addition of aliphatic, aromatic, or heterocyclic FREE RADICALS as well as EPOXIDES and arene oxides to GLUTATHIONE. Addition takes place at the SULFUR. It also catalyzes the reduction of polyol nitrate by glutathione to polyol and nitrite.
A subclass of enzymes of the transferase class that catalyze the transfer of a methyl group from one compound to another. (Dorland, 28th ed) EC 2.1.1.
The measurement of the amplitude of the components of a complex waveform throughout the frequency range of the waveform. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
A technique applicable to the wide variety of substances which exhibit paramagnetism because of the magnetic moments of unpaired electrons. The spectra are useful for detection and identification, for determination of electron structure, for study of interactions between molecules, and for measurement of nuclear spins and moments. (From McGraw-Hill Encyclopedia of Science and Technology, 7th edition) Electron nuclear double resonance (ENDOR) spectroscopy is a variant of the technique which can give enhanced resolution. Electron spin resonance analysis can now be used in vivo, including imaging applications such as MAGNETIC RESONANCE IMAGING.
Systems of enzymes which function sequentially by catalyzing consecutive reactions linked by common metabolic intermediates. They may involve simply a transfer of water molecules or hydrogen atoms and may be associated with large supramolecular structures such as MITOCHONDRIA or RIBOSOMES.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms.
A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.

p50(cdc37) acting in concert with Hsp90 is required for Raf-1 function. (1/2081)

Genetic screens in Drosophila have identified p50(cdc37) to be an essential component of the sevenless receptor/mitogen-activated kinase protein (MAPK) signaling pathway, but neither the function nor the target of p50(cdc37) in this pathway has been defined. In this study, we examined the role of p50(cdc37) and its Hsp90 chaperone partner in Raf/Mek/MAPK signaling biochemically. We found that coexpression of wild-type p50(cdc37) with Raf-1 resulted in robust and dose-dependent activation of Raf-1 in Sf9 cells. In addition, p50(cdc37) greatly potentiated v-Src-mediated Raf-1 activation. Moreover, we found that p50(cdc37) is the primary determinant of Hsp90 recruitment to Raf-1. Overexpression of a p50(cdc37) mutant which is unable to recruit Hsp90 into the Raf-1 complex inhibited Raf-1 and MAPK activation by growth factors. Similarly, pretreatment with geldanamycin (GA), an Hsp90-specific inhibitor, prevented both the association of Raf-1 with the p50(cdc37)-Hsp90 heterodimer and Raf-1 kinase activation by serum. Activation of Raf-1 via baculovirus coexpression with oncogenic Src or Ras in Sf9 cells was also strongly inhibited by dominant negative p50(cdc37) or by GA. Thus, formation of a ternary Raf-1-p50(cdc37)-Hsp90 complex is crucial for Raf-1 activity and MAPK pathway signaling. These results provide the first biochemical evidence for the requirement of the p50(cdc37)-Hsp90 complex in protein kinase regulation and for Raf-1 function in particular.  (+info)

Salmonella typhimurium and lipopolysaccharide stimulate extracellularly regulated kinase activation in macrophages by a mechanism involving phosphatidylinositol 3-kinase and phospholipase D as novel intermediates. (2/2081)

Activation of the extracellularly regulated kinase (ERK) pathway is part of the early biochemical events that follow lipopolysaccharide (LPS) treatment of macrophages or their infection by virulent and attenuated Salmonella strains. Phagocytosis as well as the secretion of invasion-associated proteins is dispensable for ERK activation by the pathogen. Furthermore, the pathways used by Salmonella and LPS to stimulate ERK are identical, suggesting that kinase activation might be solely mediated by LPS. Both stimuli activate ERK by a mechanism involving herbimycin-dependent tyrosine kinase(s) and phosphatidylinositol 3-kinase. Phospholipase D activation and stimulation of protein kinase C appear to be intermediates in this novel pathway of MEK/ERK activation.  (+info)

Involvement of tyrosine phosphorylation in HMG-CoA reductase inhibitor-induced cell death in L6 myoblasts. (3/2081)

Our previous studies have shown that the HMG-CoA reductase (HCR) inhibitor (HCRI), simvastatin, causes myopathy in rabbits and kills L6 myoblasts. The present study was designed to elucidate the molecular mechanism of HCRI-induced cell death. We have demonstrated that simvastatin induces the tyrosine phosphorylation of several cellular proteins within 10 min. These phosphorylations were followed by apoptosis, as evidenced by the occurrence of internucleosomal DNA fragmentation and by morphological changes detected with Nomarski optics. Simvastatin-induced cell death was prevented by tyrosine kinase inhibitors. The MTT assay revealed that the addition of mevalonic acid into the culture medium partially inhibited simvastatin-induced cell death. Thus, these results suggested that protein tyrosine phosphorylation might play an important role in the intracellular signal transduction pathway mediating the HCRI-induced death of myoblasts.  (+info)

Role of a novel photosystem II-associated carbonic anhydrase in photosynthetic carbon assimilation in Chlamydomonas reinhardtii. (4/2081)

Intracellular carbonic anhydrases (CA) in aquatic photosynthetic organisms are involved in the CO2-concentrating mechanism (CCM), which helps to overcome CO2 limitation in the environment. In the green alga Chlamydomonas reinhardtii, this CCM is initiated and maintained by the pH gradient created across the chloroplast thylakoid membranes by photosystem (PS) II-mediated electron transport. We show here that photosynthesis is stimulated by a novel, intracellular alpha-CA bound to the chloroplast thylakoids. It is associated with PSII on the lumenal side of the thylakoid membranes. We demonstrate that PSII in association with this lumenal CA operates to provide an ample flux of CO2 for carboxylation.  (+info)

Inactivation of both RNA binding and aconitase activities of iron regulatory protein-1 by quinone-induced oxidative stress. (5/2081)

Iron regulatory protein-1 (IRP-1) controls the expression of several mRNAs by binding to iron-responsive elements (IREs) in their untranslated regions. In iron-replete cells, a 4Fe-4S cluster converts IRP-1 to cytoplasmic aconitase. IRE binding activity is restored by cluster loss in response to iron starvation, NO, or extracellular H2O2. Here, we study the effects of intracellular quinone-induced oxidative stress on IRP-1. Treatment of murine B6 fibroblasts with menadione sodium bisulfite (MSB), a redox cycling drug, causes a modest activation of IRP-1 to bind to IREs within 15-30 min. However, IRE binding drops to basal levels within 60 min. Surprisingly, a remarkable loss of both IRE binding and aconitase activities of IRP-1 follows treatment with MSB for 1-2 h. These effects do not result from alterations in IRP-1 half-life, can be antagonized by the antioxidant N-acetylcysteine, and regulate IRE-containing mRNAs; the capacity of iron-starved MSB-treated cells to increase transferrin receptor mRNA levels is inhibited, and MSB increases the translation of a human growth hormone indicator mRNA bearing an IRE in its 5'-untranslated region. Nonetheless, MSB inhibits ferritin synthesis. Thus, menadione-induced oxidative stress leads to post-translational inactivation of both genetic and enzymatic functions of IRP-1 by a mechanism that lies beyond the "classical" Fe-S cluster switch and exerts multiple effects on cellular iron metabolism.  (+info)

Stimulation of ultraviolet-induced apoptosis of human fibroblast UVr-1 cells by tyrosine kinase inhibitors. (6/2081)

Damnacanthal is an anthraquinone compound isolated from the root of Morinda citrifolia and was reported to have a potent inhibitory activity towards tyrosine kinases such as Lck, Src, Lyn and EGF receptor. In the present study, we have examined the effects of damnacanthal on ultraviolet ray-induced apoptosis in ultraviolet-resistant human UVr-1 cells. When the cells were treated with damnacanthal prior to ultraviolet irradiation, DNA fragmentation was more pronounced as compared to the case of ultraviolet irradiation alone. The other tyrosine kinase inhibitors, herbimycin A and genistein, also caused similar effects on ultraviolet-induced apoptosis but to a lesser extent. Serine/threonine kinase inhibitors, K252a, staurosporine and GF109203X, rather suppressed the ultraviolet-induced DNA cleavage. Immunoblot analysis showed that pretreatment with damnacanthal followed by ultraviolet irradiation increased the levels of phosphorylated extracellular signal-regulated kinases and stress-activated protein kinases. However, the other tyrosine kinase inhibitors did not increase the phosphorylation of extracellular signal-regulated kinases but stimulated phosphorylation of stress-activated protein kinases. Consequently, the ultraviolet-induced concurrent increase in both phosphorylated extracellular signal-regulated kinases and stress-activated protein kinases after pretreatment with damnacanthal might be characteristically related to the stimulatory effect of damnacanthal on ultraviolet-induced apoptosis.  (+info)

Effects of pyrogallol, hydroquinone and duroquinone on responses to nitrergic nerve stimulation and NO in the rat anococcygeus muscle. (7/2081)

1. The hypothesis that endogenous superoxide dismutase (SOD) protects the nitrergic transmitter from inactivation by superoxide and that this explains the lack of sensitivity of the transmitter to superoxide generators was tested in the rat isolated anococcygeus muscle. 2. Responses to nitrergic nerve stimulation or to NO were not significantly affected by exogenous SOD or by the Cu/Zn SOD inhibitor diethyldithiocarbamic acid (DETCA). 3. Hydroquinone produced a concentration-dependent reduction of responses to NO with an IC50 of 27 microM, and higher concentrations reduced relaxant responses to nitrergic nerve stimulation with an IC50 of 612 microM. The effects of hydroquinone were only slightly reversed by SOD, so it does not appear to be acting as a superoxide generator. 4. Pyrogallol produced a concentration-dependent reduction in responses to NO with an IC50 value of 39 microM and this effect was reversed by SOD (100-1000 u ml(-1)). Pyrogallol did not affect responses to nitrergic nerve stimulation. Treatment with DETCA did not alter the differentiating action of pyrogallol. 5. Duroquinone produced a concentration-dependent reduction of relaxations to NO with an IC50 value of 240 microM and 100 microM slightly decreased nitrergic relaxations. After treatment with DETCA, duroquinone produced greater reductions of relaxant responses to NO and to nitrergic stimulation, the IC50 values being 8.5 microM for NO and 40 microM for nitrergic nerve stimulation: these reductions were reversed by SOD. 6. The findings do not support the hypothesis that the presence of Cu/Zn SOD explains the greater susceptibility of NO than the nitrergic transmitter to the superoxide generator pyrogallol, but suggest that it may play a role in the effects of duroquinone.  (+info)

Tyrosine kinase-dependent modulation by interferon-alpha of the ATP-sensitive K+ current in rabbit ventricular myocytes. (8/2081)

We examined the effects of interferon-alpha on the ATP-sensitive K+ current (IK,ATP) in rabbit ventricular cells using the patch-clamp technique. IK,ATP was induced by NaCN. Whole-cell experiments indicated that interferon-alpha (5 x 10(2) - 2.4 x 10(4) U/ml) inhibited IK,ATP in a concentration-dependent manner (60.7+/-7.5% with 2.4 x 10(4) U/ml). In cell-attached configuration, interferon-alpha (2.4 x 10(4) U/ml) applied to the external solution also inhibited the activity of the single ATP-sensitive K+ (KATP) channel by 56.0+/-5.8% without affecting the single channel conductance. The inhibitory effect of IK,ATP by interferon-alpha was blocked by genistein and herbimycin A, tyrosine kinase inhibitors, but was not affected by N-(2-metylpiperazyl)-5-isoquinolinesulfoamide (H-7), an inhibitor of protein kinase C and cAMP-dependent protein kinase. These findings suggest that interferon-alpha inhibits the cardiac KATP channel through the activation of tyrosine kinase. The tyrosine kinase-mediated inhibition of IK,ATP by cytokines may aggravate cell damage during myocardial ischemia.  (+info)

Product Details of P-Benzoquinone CAS 106-51-4 Benzoquinone p-Benzoquinone P-quinone PBQ Quinone, P-Benzoquinone CAS 106-51-4 Benzoquinone p-Benzoquinone P-quinone PBQ Quinone from China manufacturer on Hisupplier.com.
Using cyclic voltammetry, the electrochemistry of aqueous solutions of 4-methoxy-1,2-benzoquinone was investigated over the pH range 0-8. From the variation of half-wave potential with pH, it was inferred that the quinone was reduced to the hydroquinone; no acid-base reactions involving either the quinone or hydroquinone were observed. At low pH ( , 3), the cyclic voltammogram of the benzoquinone changed rapidly to a second pair of peaks at lower potentials. These were shown to be due to 2-hydroxy-1,4-benzoquinone, formed by hydrolysis of the original compound. The other hydrolysis product, methanol, was detected chromatographically. The hydrolysis reaction was shown to be first order both with respect to the 1,2-benzoquinone and protons. At pH 6 and above, 4-methoxy-1,2-benzoquinone showed a second type of decomposition whose rate was approximately first order in hydroxide ion. Using electrochemical and spectroscopic measurements, it was also demonstrated that 4-methoxy-1,2-benzoquinone was ...
The invention relates to benzoquinone ansamycin analogs useful for the treatment of cancer and other diseases or conditions characterized by undesired cellular proliferation or hyperproliferation. Therapies involving the administration of such benzoquinone ansamycin analogs, optionally in combination with an inhibitor of an HSP90 client protein, are useful to treat cancer and non-cancerous disease conditions.
Seratrodast (development name, AA-2414; marketed originally as Bronica) is a thromboxane A2 (TXA2) receptor (TP receptor) antagonist used primarily in the treatment of asthma. It was the first TP receptor antagonist that was developed as an anti-asthmatic drug and received marketing approval in Japan in 1997. As of 2017 seratrodast was marketed as Bronica in Japan, and as Changnuo, Mai Xu Jia, Quan Kang Nuo in China. Unlike thromboxane synthase inhibitors such as ozagrel, seratrodast does not affect thrombus formation, time to occlusion and bleeding time. Seratrodast has no effect on prothrombin time and activated partial thromboplastin time, thus ruling out any action on blood coagulation cascade. Seratrodast is used to treat asthma. There are no adequate and well-controlled studies of seratrodast in pregnant women. The drug should be used in pregnancy only if the potential benefits justify the risk to the fetus. Seratrodast should not be used during lactation. The safety and efficacy of ...
Guo W, Reigan P, Siegel D, Ross D. Enzymatic reduction and glutathione conjugation of benzoquinone ansamycin heat shock protein 90 inhibitors: relevance for toxicity and mechanism of action. Drug Metab Dispos. 2008 Oct; 36(10):2050-7 ...
Alfa Aesar™ 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone, 98+% 10g Alfa Aesar™ 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone, 98+% Dichlorotol to...
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1,4-Benzoquinone 常見於的活性的結構分子中,亦被廣泛地運用在藥物結構修飾。 在化學反應上,1,4-benzoquinone 較常進行的是親核基取代反應,藉由這一類的反應能 導入不同的基團,經常能提升化合物的生物活性。然而,此類的親核基取代反應對於 取代在 C2或 C3位置,並無太大的選擇性。為了提高化學選擇性、清楚了解取代基位 置對於生物活性的影響,本計畫將以兩類具 1,4-benzoquinone結構的 quinoline-5,8-dione 及天然物 denbinobin 作為探討對象,利用離去基導向、溫度控制及路易士酸輔助等方 法,提高親核基取代反應的位向選擇性,合成一系列的 2-aroyl-quinoline-5,8-dione 及 denbinobin 衍生物,初步的實驗數據顯示 2-aroyl-quinoline-5,8-dione 及 denbinobin 衍生 物接具有良好的癌細胞生長抑制效果,因此本計畫將持續探討不同取代基對於活性的 影響,同時計畫合成各式 ...
TY - JOUR. T1 - Disruption of the EF-2 kinase/Hsp90 protein complex. T2 - A possible mechanism to inhibit glioblastoma by geldanamycin. AU - Yang, Jun. AU - Yang, Jin Ming. AU - Iannone, Marie. AU - Shih, Weichung Joe. AU - Lin, Yong. AU - Hait, William N.. PY - 2001/5/15. Y1 - 2001/5/15. N2 - Glioblastoma multiforme is the most treatment-resistant brain tumor. Elongation factor-2 (EF-2) kinase (calmodulin kinase III) is a unique protein kinase that is overexpressed in glioma cell lines and in human surgical specimens. Several mitogens activate this kinase and inhibitors block mitogen activation and produce cell death. Geldanamycin (GA) is a benzoquinone ansamycin antibiotic that disrupts Hsp90-protein interactions. Because EF-2 kinase is chaperoned by Hsp90, we investigated the effects of GA on the viability of glioma cells, the expression of EF-2 kinase protein, and the interaction between Hsp90 and EF-2 kinase. GA was a potent inhibitor of the clonogenicity of four glioma cells lines with ...
TY - JOUR. T1 - Poly-vinylidene-fluoride/p-benzoquinone gel polymer electrolyte with good performance by redox mediator effect for Li-Air battery. AU - Kim, Young Bok. AU - Kim, Il To. AU - Song, Myeong Jun. AU - Shin, Moo Whan. PY - 2016/8/20. Y1 - 2016/8/20. N2 - In this study, the poly-vinylidene fluoride (PVDF)/p-benzoquinone (pBQ) gel polymer electrolyte (GPE) is synthesized well with LiTFSI/TEGDME for Li-Air battery (LAB) applications. The PVDF/pBQ GPEs are characterized by electrochemical analysis and compared to the PVDF GPE. We confirm that pBQ molecule in PVDF GPE shows redox mediate behavior during charge-discharge process. Employing PVDF/pBQ GPE for LAB leads to an improved cycleability from 2 to over 30. In addition it results in a charge voltage decrease from around 4.2 V to around 3.3 V. The energy cycle efficiency (ECE) is improved about 15%. The pBQ accelerates to the formation of an amorphous phase on synthesized PVDF GPE matrix by acting inhibitor for polymerization. It leads ...
Buy low price P-Benzoquinone online from SHILPA INTERNATIONAL SPECIALTIES based in BELAPUR-CBD-BELAPUR, Navi Mumbai. Get product specifications and salient feature of P-Benzoquinone along with company address and contact details.
Studies with four benzoquinones, viz. juglone, embelin, maesaquinone and maesanin, on rat liver mitochondria oxidative phosphorylation have been carried out. Three of the benzoquinones are uncouplers in the order juglone , maesoquinone , embelin, while maesanin is an inhibitor of electron transport and oxidative phosphorylation ...
J. O. Midiwo, A. Yenesew, B. F. Juma, S. Dereses, J. A. Ayoo, A. Aluoch and S. Guchu There are several described medicinal plants in Kenya from a flora of approximately 10,000 members. Strong cross-medical information from the 42 ethnic groups points to the high potential of some of these species. The Myrsinaceae are well established ethno-anthelmintics and anti-bacterials. They are harbingers of long alkyl side chain benzoquinones which clearly have a protective function from their histochemical disposition. The main benzoquinone in the sub-family Myrsinodae is embelin while for the Maesodae it is maesaquinone together with its 5-acetyl derivative; the distribution of these benzoquinones by their alkyl side chain length or the presence/absence of a 6-methyl group is in accord with morphological sub-family de-limitation. The benzoquinones showed anti-feedant, anti-microbial, phytotoxic, acaricidal, insecticidal and nematicidal activity. Many other benzoquinones of medium and minor concentration ...
When I first tried this I bought a 30 % H2O2 under the name Baquacil and I tried the Erowid version of the synthesis and dripping the H2O2 with almost no fizzing in a two necked 500 ml rbf which only resulted in quinhydrone. Only until I boiled the reaction contents for a minute to a minute and a half while refluxing after I added the H2O2 wholesale did the hydroquinone go all the way to Benzoquinone after the boiling I would chill the rbf immediately in an icebath and then it would promptly go into the freezer for crystalization. Now I have returned to make more with the same gallon of H2O2 which I put in a refridgerator and I painted the walls when I added the H2O2 wholesale and tried to boil it the first time which prompted me to make a blast hood out of 2x4s and clear plastic. I took the Baquacil out of the fridge and let it sit for a day or two hoping the temp would raise and it would react like it did in the past and it seemed even more exothermic when I tried to add it wholesale somehow ...
Benzoquinone ansamycin (BQA) Hsp90 inhibitors such as 17-DMAG and 17-AAG have off-target toxicities in clinical trials including hepatotoxicity. Mechanisms underlying the toxicity of quinones are a function of their ability to redox cycle and/or arylate cellular nucleophiles at the unsubstituted 19-position of the molecule. Therefore, we designed 19-substituted BQAs to prevent glutathione conjugation and non-specific interactions with protein thiols as an approach to reduce the hepatotoxicity and minimize off-target effects of the BQA class of Hsp90 inhibitors. In this study, the results showed that 19-substituted BQAs did not react with glutathione at the 19-position, while marked reactivity was observed using parent BQAs. Importantly, while parent 17-DMAG induced cell death in primary and cultured mouse hepatocytes, 19-phenyl and 19-methyl 17-DMAG showed reduced toxicity, validating the overall approach. There was no significant difference between the redox cycling ability of either 19-phenyl ...
Creative-Proteomics offer cas 106-51-4 1,4-BENZOQUINONE (D4, 98%). We are specialized in manufacturing Stabel Isotope Labeled Analytical Standard products.
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OUTLINE: This is a single-center, dose-escalation study.. Patients receive 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) IV over 1-2 hour on days 1 and 4 or days 2 and 5 weekly for 4 weeks. Treatment repeats every 4 weeks in the absence of disease progression or unacceptable toxicity.. Cohorts of 1-6 patients receive escalating doses of 17-DMAG until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2 of up to 6 patients experience dose-limiting toxicity. Once the MTD is determined, 10 additional patients are treated at the MTD.. PROJECTED ACCRUAL: Approximately 40 patients will be accrued for this study within 2 years. ...
RATIONALE: Drugs used in chemotherapy, such as 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG), work in different ways to stop the g
Looking for online definition of 1,4-benzoquinone in the Medical Dictionary? 1,4-benzoquinone explanation free. What is 1,4-benzoquinone? Meaning of 1,4-benzoquinone medical term. What does 1,4-benzoquinone mean?
PRIMARY OBJECTIVES:. I. To determine the maximum tolerated dose of geldanamycin analogue (AAG) in patients with advanced solid tumors.. II. To determine the toxic effects of this drug in this patient population. III. To determine the biochemical and molecular effects of this drug in normal and accessible tumor tissue in these patients.. IV. To determine the pharmacokinetics of this drug in these patients. V. To assess any antitumor activity of this drug in these patients.. OUTLINE: This is a dose-escalation study.. Patients receive geldanamycin analogue (AAG) IV over 1-6 hours once daily on days 1, 4, 15, and 18. Courses repeat every 4 weeks in the absence of disease progression or unacceptable toxicity. Cohorts of 3-6 patients receive escalating doses of AAG until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2 of 6 patients experience dose-limiting toxicity. Once the MTD is determined, an additional 10 patients are treated at the ...
Thymoquinone, a major ingredient of black seed oil (Nigella sativa), has been shown to exhibit anticancer capacity in various types of cancers. However, there are few studies concerning the correlation between thymoquinone and epithelial-to-mesenchymal transition (EMT) in prostate cancer. In the present study, we firstly found that thymoquinone showed antimetastatic capacity in prostate cancer DU145 and PC3 cells. Additionally, thymoquinone reversed EMT by increasing E-cadherin expression and decreasing vimentin and Slug expression in a concentration-dependent manner. Recent studies have shown that the transforming growth factor-β (TGF-β) signaling pathway may be associated with EMT. Intriguingly, the expression of TGF-β, Smad2 and Smad3 at the mRNA and protein levels was notably reduced upon thymoquinone treatment in prostate cancer DU145 and PC3 cells. Subsequently, we confirmed that thymoquinone repressed metastasis and EMT of prostate cancer through downregulation of the TGF-β/Smad2/3 ...
Self-dimerisation of the three isomeric semiquinone radicals is considered herein. Optimised geometries and thermochemical parameters, in terms of heat of formation, entropy, heat capacity and Gibbs free energy of formation are provided for all possible cross coupling products. It is found that self-dimerisation of the three semiquinone radicals is not as thermodynamically favoured as the self-dimerisation of the phenoxy radical. Accordingly, the three isomeric semiquinone radicals can be regarded as less active precursors for the formation of dioxin compounds than phenoxy radicals.. ...
TY - CHAP. T1 - Tissue distribution and intracerebral tumor penetration of 2,5-diaziridinyl-3,6-biscarboethoxyamino-1,4-benzoquinone (AZO, NSC 182986) in man. AU - Savaraj, Niramol. AU - Lu, K.. AU - Stewart, D.. PY - 1981/1/1. Y1 - 1981/1/1. UR - http://www.scopus.com/inward/record.url?scp=17544399898&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=17544399898&partnerID=8YFLogxK. M3 - Chapter. AN - SCOPUS:17544399898. VL - Vol. 22. BT - Proceedings of the American Association for Cancer Research. ER - ...
Thymoquinone is an active ingredient isolated from Nigella sativa and has been investigated for its anti-oxidant, anti-inflammatory and anticancer activities in both in vitro and in vivo models since its first extraction in 1960s. Its anti-oxidant/anti-inflammatory effect has been reported in various disease models, including encephalomyelitis, diabetes, asthma and carcinogenesis. Moreover, thymoquinone could act as a free radical and superoxide radical scavenger, as well as preserving the activity of various anti-oxidant enzymes such as catalase, glutathione peroxidase and glutathione-S-transferase. The anticancer effect(s) of thymoquinone are mediated through different modes of action, including anti-proliferation, apoptosis induction, cell cycle arrest, ROS generation and anti-metastasis/anti-angiogenesis. In addition, this quinone was found to exhibit anticancer activity through the modulation of multiple molecular targets, including p53, p73, PTEN, STAT3, PPAR-γ, activation of caspases ...
Results of the present study indicate that cotreatment with the Hsp90 antagonist 17-AAG and clinically relevant HDAC inhibitors results in a striking increase in mitochondrial injury, caspase activation, and apoptosis in Bcr-Abl+ human leukemia cells. These events are associated with Bcr-Abl down-regulation; multiple perturbations in Bcl-2 family member proteins, particularly induction of Bax conformational change; and disruption of diverse signaling/cell cycle regulatory pathways, including those related to STAT5, Raf/MEK/ERK, and Akt.. Translocation and integration of cytoplasmic Bax into the mitochondrial membrane represent critical steps in activation of the mitochondrial apoptotic pathway in multiple systems (Yamaguchi et al., 2003). Moreover, a conformational change in Bax, resulting in exposure of the NH2 and COOH termini, is required for release of proapoptotic mitochondrial proteins (Murphy et al., 2000). The present results demonstrate that 17-AAG induces a conformational change in Bax ...
A number of molecular therapeutic agents, derived from exploiting our knowledge of the oncogenic pathways that are frequently deregulated in cancer, are now entering clinical trials. One of these is the novel agent 17-allylamino-17-demethoxygeldanamycin that acts to inhibit the hsp90 molecular chape …
I found nothing on any possible reaction between acetone and p-benzoquinone with SciFinder. If there would be a reaction under basic conditions, I would guess that 5-hydroxy-2-methylbenzofurane would be the expected product. I would guess the reason why this apparently does not happen is because benzoquinone is unlikely to be stable toward the strong bases required for the enolization of acetone (such as hydroxides which can react with quinones themselves ...
This phase I trial is studying the side effects and best dose of giving PDX101 together with 17-AAG in treating patients with metastatic or unresectable
The invention relates to a new type of highly polar, at least double-negatively charged redox-active benzoquinones, notably derived from Coenzyme Q0, Q1 and dimethoxy benzoquinones, its production and use. The production of these benzoquinones comprises the reaction of dimethoxy benzoquinones with highly alkaline aqueous solutions. The benzoquinones of the invention have various potential applications in pharmaceutical and cosmetic industry (namely as antioxidants, anti-ageing agents and the like), in organic synthesis, metal complexations, metal separations, potentiometric titrations, interfacial catalysis, and ion-transfer reactions across biological membranes.. ...
Herbimycin A, 1 mg. Herbimycin A, a benzoquinoid ansamycin antibiotic, irreversibly and selectively inhibits tyrosine kinases by reacting with thiol groups (1,2).
1. HT-29 M6 cells are a subpopulation of HT-29 cells that, contrarily to the parental cells, establish tight cell contacts and differentiate. Cell-to-cell contacts in HT-29 M6 cells are also regulated by protein kinase C; addition of the phorbol ester phorbol 12-myristate 13-acetate (PMA) decreases the homotypic contacts of these cells. We show here that HT-29 cells or HT-29 M6 cells treated with PMA contain lower levels of functional E-cadherin, determined by analysing the association of this protein with the cytoskeleton. No significant differences in the localization of α-, β-, or p120-catenins were detected under the three different conditions. 2. Dysfunction of E-cadherin can be reversed by incubation of HT-29 cells with the tyrosine kinase inhibitor herbimycin A. On the other hand an augmentation of c-src activity in HT-29 cells or HT-29 M6 cells treated with PMA was observed with respect to control HT-29 M6 cells. The phosphorylation status of catenins was also investigated; in HT-29 or ...
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sativa and several of its Lively compounds, such as thymoquinone and alpha-hederin. Acute and Continual toxicity reports have just lately verified the security of N. sativa oil and its most plentiful active ingredient, thymoquinone, especially when given orally. The present do the job is aimed toward summarizing the exceptionally worthwhile work accomplished by various investigators on the effects of N. sativa seed, its extracts and Lively principles versus most cancers. Those connected with the underlying system of action, derivatives of thymoquinone, nano thymoquinone and combos of thymoquinone Along with the at the moment employed cytotoxic medicines are of distinct curiosity. We hope this critique will stimulate intrigued scientists to conduct even more preclinical and medical experiments to evaluate the anticancer actions of N. sativa, its Energetic constituents as well as their derivatives ...
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Four naturally occurring dimeric phenylethyl benzoquinones, parvistemins A-D, were isolated from the aerial parts of Stemona parviflora Wright. Their constitutions were established by spectroscopic methods. Due to restricted rotation about the central biaryl axis, the compounds are chiral, although racemic. Their two respective atropo-enantiomers were resolved by HPLC on a chiral phase and were stereochemically characterized online, in hyphenation with circular dichroism (CD) spectroscopy (LC-CD coupling), combined with quantum chemical CD calculations ...
TY - JOUR. T1 - Geldanamycin selectively targets the nascent form of ERBB3 for degradation. AU - Gerbin, Candice S.. AU - Landgraf, Ralf. PY - 2010/9. Y1 - 2010/9. N2 - Heat shock protein 90 (HSP90) targets a broad spectrum of client proteins with divergent modes of interaction and consequences. The homologous epidermal growth factor receptor (EGFR) and ERBB2 receptors as well as kinase-deficient mutants thereof differ in their requirement for HSP90 in the nascent versus mature state of the receptor. Specific features of the kinase domain have been implicated for the selective association of HSP90 with mature ERBB2. We evaluated the role of HSP90 for the homologous ERBB3 receptor. ERBB3 is naturally kinase deficient, a central mediator in cell survival and stress response and the primary dimerization partner for ERBB2 in signaling. Cellular studies indicate that, similar to EGFR, the geldanamycin (GA) sensitivity of ERBB3 and HSP90 binding resides in the nascent state and is dependent on the ...
Also, the expression of cleaved caspase-3 and Smac were being upregulated in SaOS-two cells just after treatment with thymoquinone. In combination with these in vitro effects, we also discovered that thymoquinone inhibits tumor angiogenesis and tumor development via suppressing NF-κB and its controlled molecules. Collectively, our final results demonstrate that thymoquinone successfully inhibits tumor growth and angiogenesis both in vitro As well as in vivo. In addition, inhibition of NF-κB and downstream effector molecules is often a attainable fundamental mechanism on the antitumor and anti-angiogenic action of thymoquinone in osteosarcoma ...
Introduction of Idebenone Just what is Idebenone? Those of you who have inquired into the Idebenone compound will see that the internet is awash with all manner
FIGURE 2. A. TQ inhibits TNF-induced degradation of IκBα. KBM-5 cells were incubated with 25 μmol/L TQ for 4 h and treated with 0.1 nmol/L TNF for the indicated times. Cytoplasmic extracts were prepared and analyzed by Western blotting using antibodies against anti-IκBα. Representative of two or three independent experiments. Equal protein loading was evaluated by β-actin (bottom). B. TQ blocks the phosphorylation of IκBα by TNF. Cells were preincubated with 25 μmol/L TQ for 4 h, incubated with 50 μg/mL N-acetyl-leucylleucyl-norleucinal for 30 min, and then treated with 0.1 nmol/L TNF for 10 min. Cytoplasmic extracts were fractionated and then subjected to Western blot analysis using phosphorylated-specific anti-IκBα antibody. The same membrane was reblotted with β-actin antibody. C. The effect of TQ on the activation of IKK by TNF was investigated. KBM-5 cells were incubated with 25 μmol/L TQ for 4 h, incubated with 50 μg/mL N-acetyl-leucylleucyl-norleucinal for 30 min, and then ...
Idebenone is a member of the quinone family, and like hydroquinone, has been used in various skin care regimes. Know more about Idebenone.
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This page includes the following topics and synonyms: Conenzyme Q10, Ubiquinone, CoQ, Vitamin Q10, 2,3 Dimethoxy-5-Methyl-6-Decaprenyl Benzoquinone.
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Rikova K (2013) CST Curation Set: 18855; Year: 2013; Biosample/Treatment: cell line, H3122/crizotinib, geldanamycin; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: acK ...
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para-Benzoquinone in DMSO. A solution of para-benzoquinone in DMSO reacts with inorganic cyanide to form a cyanophenol, which ... "Fluorometric determination of cyanide in biological fluids with p-benzoquinone*1". Toxicology and Applied Pharmacology. 55 (1 ...
1,4-benzoquinone Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa ... The oxidation of aniline by manganese dioxide followed by reduction of the resulting 1,4-benzoquinone. The process is conducted ... When colorless hydroquinone and benzoquinone, a bright yellow solid, are co-crystallized in a 1:1 ratio, a dark-green ... Hydroquinone undergoes oxidation under mild conditions to give benzoquinone. This process can be reversed. Some naturally ...
Simple phenols, Benzoquinones Catechol, Hydroquinone, 2,6-Dimethoxybenzoquinone 7 C6-C1 1 Phenolic acids, Phenolic aldehydes ...
"Alkylated benzoquinones from Iris kumaonensis". Phytochemistry. 61 (8): 923-926. doi:10.1016/S0031-9422(02)00474-0. PMID ...
"A new alkylated benzoquinone from rhizomes of Iris kumaonensis". Nat. Prod. Res. 20 (1): 75-78. doi:10.1080/14786410500045721. ... it found several compounds including a benzoquinone. As most irises are diploid, having two sets of chromosomes, this can be ... "Alkylated benzoquinones from Iris kumaonensis". Phytochemistry. 61 (8): 923-926. doi:10.1016/S0031-9422(02)00474-0. PMID ...
The benzoquinones may be carcinogenic. Before the beetle became problematic in poultry, it was better known as a pest of stored ... Like other darkling beetles, this species produces defensive benzoquinone compounds that can be irritating to humans, causing ...
Among the many irritant and toxic chemicals found in these secretions are alkaloids, benzoquinones, phenols, terpenoids, and ... Weldon, Paul J.; Aldich, Jeffrey R.; Klun, Jerome A.; Oliver, James E.; Debboun, Mustapha (2003). "Benzoquinones from ... is elicited by benzoquinones from millipedes". Naturwissenschaften. 93 (1): 14-16. Bibcode:2006NW.....93...14W. doi:10.1007/ ...
Harman, R. E. (1963). "Chloro-p-benzoquinone". Organic Syntheses.; Collective Volume, 4, p. 148 Kamm, O. (1941). "β- ...
Harman, R. E. (1955). "Chloro-p-benzoquinone" (PDF). Organic Syntheses. 35: 22.; Collective Volume, 4, p. 148 Oxley, P. W.; ...
Para-benzoquinones in the secretion of spirostreptoid millipedes. - Annals of the Entomological Society of America 58 (2): 247- ... Para-benzoquinones in the secretion of spirostreptoid millipedes". Annals of the Entomological Society of America. 58 (2): 247- ...
Cyanosilylation of p-Benzoquinone". Org. Synth. 60: 126. doi:10.15227/orgsyn.060.0126.CS1 maint: uses authors parameter (link) ...
Cyanosilylation of p-Benzoquinone". Org. Synth. 60: 126. doi:10.15227/orgsyn.060.0126. Haroutounian, Serkos A. (2001). "Acetone ...
Livinghouse, T. (1990). "Trimethylsilyl Cyanide: Cyanosilation of p-Benzoquinone". Organic Syntheses.; Collective Volume, 7, p ...
For the latter, benzoquinone is suggested. http://www.merckmillipore.com/INTL/en/product/pharmaceutical-ingredients/potassium- ...
NQ01 metabolizes benzoquinone toward polyphenols (counteracting the effect of MPO). GSH is involved with the formation of ... In the bone marrow, MPO converts these polyphenols to benzoquinones. These intermediates and metabolites induce genotoxicity by ...
Investigations into the types of metabolites produced by this fungus have found that it produces benzoquinone derivatives, ... Lana, EJL; Carazza, F; Takahashi, JA (2006). "Antibacterial Evaluation of 1,4-Benzoquinone Derivatives". J. Agric. Food Chem. ... Chaetoglobosins has been found to have anticancer activity, and benzoquinone derivatives have antibacterial properties. ...
1,2-Benzoquinone 1,4-Benzoquinone 1,4-Naphthoquinone 9,10-Anthraquinone The term quinone is also used more generally for a ... Benzoquinone is used in organic chemistry as an oxidizing agent. Strongly oxidizing quinones include chloranil and 2,3-dichloro ... Dahlin, D. C.; Miwa, G. T.; Lu, A. Y.; Nelson, S. D. (1984). "N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated ... Benzoquinone compounds are a metabolite of paracetamol. Many natural and artificial coloring substances (dyes and pigments) are ...
Weldon, P.J., Aldrich, J.R., Klun, J.A., Oliver, J. E. and Debboun, M. (2003). "Benzoquinones from millipedes deter mosquitoes ... A range of primates rub millipedes onto their fur and skin; millipedes contain benzoquinones, compounds known to be potently ...
Nazli Rasool, Abdul Qasim Khan, Viqar Uddin Ahmad and Abdul Malik (1991). A benzoquinone and a coumestan from Psoralea plicata ...
Chemically, it is a polyphenol and a benzoquinone. Atromentin has been found in cultures of Clitocybe subilludens and in ...
In addition his research group studied alkylbenzenes, benzoquinones, and the Jacobsen rearrangement. Boekelheide, Virgil (1995 ...
The reaction proceeds only in the presence of sodium acetate; Moiseev used benzoquinone to regenerate the Pd(II) catalyst. CH2= ...
Brewer D, Maass WS, Taylor A (1977). "The effect on fungal growth of some 2,5-dihydroxy-1,4-benzoquinones". Canadian Journal of ... Polyporic acid is a para-terphenyl benzoquinone compound first identified by German chemist Stahlschmidt from a mycelial ... 4-benzoquinones". Canadian Journal of Microbiology. 30 (8): 1068-1092. doi:10.1139/m84-166. PMID 6541963. Schüffler A, Liermann ...
4-benzoquinone biscarbonate Tetrahydroxy-1,4-benzoquinone bisoxalate Hammond, P. R. (1963). "1,4-Benzoquinone Tetracarboxylic ...
Teuber HJ (1972). "Use of dipotassium nitrosodisulfonate (Fremy's salt): 4,5-dimethyl-o-benzoquinone". Org. Synth. 52: 88. doi: ... I. Preparation and use of sodium nitrosodisulfonate: trimethyl-p-benzoquinone". Organic Syntheses. 52: 83. doi:10.15227/orgsyn. ... 4-Benzoquinones by Degradative Oxidation of p-Hydroxybenzyl Alcohols". J. Chem. Educ. 65 (7): 627-629. doi:10.1021/ed065p627.. ...
Benzoquinone is actually not a necessary component for this reaction; its role is to regenerate palladium(II) from its reduced ... acetate without benzoquinone, while at a much higher cost. Since the reaction typically employs near-stoichiometric amounts of ... acetate and benzoquinone to yield the corresponding enone. The original publication noted its utility for regeneration of ...
The speculation is that the benzoquinone functional group is responsible. The semi-synthetic derivative 17 AAG, with lower ... "Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for ...
C8O8 or C6O2(CO3)2, tetrahydroxy-1,4-benzoquinone biscarbonate (Nallaiah, 1984); decomposes at about 45-53 °C. C9O9 or C6(CO3)3 ... C10O10 or C6O2(C2O4)2, tetrahydroxy-1,4-benzoquinone bisoxalate (Verter and others, 1968); stable as a tetrahydrofuran solvate ... Hammond P. R. (1963). "1,4-Benzoquinone Tetracarboxylic Acid Dianhydride, C10O8: A Strong Acceptor". Science. 142 (3591): 502. ... Nallaiah, C. (1984). "Synthesis of tetrahydroxy-1,4-benzoquinone biscarbonate and hexahydroxybenzene triscarbonate-new organic ...
... has role mouse metabolite (CHEBI:75771) 1,4-benzoquinone (CHEBI:16509) is a 1,4-benzoquinones ( ... 1,4-benzoquinone imine (CHEBI:50192) has functional parent 1,4-benzoquinone (CHEBI:16509). 2-prenyl-1,4-benzoquinone (CHEBI: ... 1,4-benzoquinone (CHEBI:16509) has role cofactor (CHEBI:23357) 1,4-benzoquinone (CHEBI:16509) has role human xenobiotic ... 35796) has functional parent 1,4-benzoquinone (CHEBI:16509). quinhydrone (CHEBI:26491) has part 1,4-benzoquinone (CHEBI:16509) ...
There are 2 (out of 3 hypothetical) benzoquinones: 1,4-Benzoquinone, most commonly (also para-benzoquinone, p-benzoquinone, ... also ortho-benzoquinone, o-benzoquinone, ortho-quinone) 1,3-benzoquinone "does not exist, because its structure would be ... An alkylated p-benzoquinone has been found in the rhizomes of Iris kemaonensis. Singh, N.; Mahmood, U.; Kaul, V. K.; Gupta, A. ... Benzoquinone (C6H4O2) is a quinone with a single benzene ring. ... para-quinone, or just quinone) 1,2-Benzoquinone, less commonly ...
Other names: 2,5-Cyclohexadiene-1,4-dione; p-Quinone; Chinone; Quinone; 1,4-Benzoquinone; 1,4-Cyclohexadienedione; Benzoquinone ...
1,2-Benzoquinone, also called ortho-benzoquinone, is an organic compound with formula C6H4O2. It is one of the two isomers of ... 1,2-Benzoquinone is produced on oxidation of catechol exposed to air in aqueous solution or by ortho oxidation of a phenol. It ... ISBN 978-0-85404-182-4. Liao, Chun-Chen; Peddinti, Rama Krishna (2002). "Masked o-Benzoquinones in Organic Synthesis". Accounts ... MacDonald, Alistair L.; Trotter, James (1973). "Crystal and molecular structure of o-benzoquinone". Journal of the Chemical ...
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
Most quinones, with coenzyme Q10 as their best known representative, are seen as very efficient radical scavengers and antioxidants, commonly acting in a way to protect the living cells from oxidative damage. Although its antioxidative effect is undisputable, Q10 has one big disadvantage: due to the long, hydrophobic side-chain it is only slightly water-soluble. By a new easy reaction out of the natural substances coenzyme Q1 to Q10 new compounds are formed. The ubichinons are transformed into new substances. They show high solubility due to their polrity higher anti-oxidative effect than the natural substances ...
Tetrachloro-p-benzoquinone. ↓Other names: Regulatory process names [2] Trade names [3] Other names [1] IUPAC names [13] ...
Synonyms para-Benzoquinone Dioxime. * Actor Q *1,4-Benzoquinone dioxine * Dibenzo PQD * G-M-F * PQD * QDO * para-Quinone ... para-BENZOQUINONE DIOXIME. VOL.: 29 (1982) (p. 185) CAS No.: 105-11-3. Chem. Abstr. Name: 2,5-Cyclohexadiene-1,4-dione, dioxime ... para-Benzoquinone dioxime was tested for carcinogenicity at two dose levels in mice and rats by oral administration. No ... There is limited evidence that para-benzoquinone dioxime is carcinogenic to rats.. No case report or epidemiological study was ...
In a 2L flask fitted with a reflux condenser and addition funnel place 400ml MeOH, 50ml dH2O, 150g p-Benzoquinone and 2g PdCl2 ... If you let the PdCl2 stir alone for a while, when you then add the water and benzoquinone, let them stir for an hour as well ... Filter out the solids present in the mixture, which are hydroquinone (the degradation product of the benzoquinone) and PdCl2. ... Benzoquinone Wacker Oxidation of Safrole in Methanol. by Methyl Man. HTML by Rhodium ...
1,4-Benzoquinone, commonly known as para-quinone, is a chemical compound with the formula C6H4O2. In a pure state, it forms ... Benzoquinone vapours are very irritating to the eyes and to the respiratory system. Handle in a well ventilated area, ideally ... 1,4-Benzoquinone is sensitive toward both strong mineral acids and alkali, which cause condensation and decomposition of the ... An acidic potassium iodide solution reduces a solution of benzoquinone to hydroquinone, which can be reoxidized back to the ...
N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen. D C Dahlin, G T Miwa, A Y Lu, ... N-acetyl-p-benzoquinone imine (NAPQI) has been proposed as the toxic metabolite of acetaminophen for the past 10 years, ... N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen ... N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen ...
2-isopropyl-5-methyl-p-benzoquinone. Regulatory process names 1 IUPAC names 2 Other identifiers 1 ...
To elucidate the impact of benzoquinone (BQ) on lipid homeostasis and cytotoxicity in Saccharomyces cerevisiae. Methods: The ... Benzoquinone alters the lipid homeostasis in Saccharomyces cerevisiae A. Raj and V. Nachiappan, Toxicol. Res., 2019, Advance ... Objective: To elucidate the impact of benzoquinone (BQ) on lipid homeostasis and cytotoxicity in Saccharomyces cerevisiae. ...
... MoustafaM. ... 5-dihydroxy-P-benzoquinone and amines," Spectroscopy, vol. 15, no. 1, pp. 33-44, 2001. https://doi.org/10.1155/2001/721903. ...
"Alkaline Benzoquinone Aqueous Flow Battery for Large-Scale Storage of Electrical Energy". Germany. doi:10.1002/aenm.201702056. ... title = {Alkaline Benzoquinone Aqueous Flow Battery for Large-Scale Storage of Electrical Energy},. author = {Yang, Zhengjin ... Title: Alkaline Benzoquinone Aqueous Flow Battery for Large-Scale Storage of Electrical Energy. ... Publishers Accepted Manuscript: Alkaline Benzoquinone Aqueous Flow Battery for Large-Scale Storage of Electrical Energy ...
Get product specifications and salient feature of P-Benzoquinone along with company address and contact details. ... Buy low price P-Benzoquinone online from SHILPA INTERNATIONAL SPECIALTIES based in BELAPUR-CBD-BELAPUR, Navi Mumbai. ... We manufacture, export, trade and supply p-Benzoquinone in Navi Mumbai, Maharashtra, India. Our range of p-Benzoquinone reacts ... p-Benzoquinone can act as a staining agent for proteins and polyamides. It can also used as in-process polymerization inhibitor ...
... Juan ... Juan Zhang, Meng Cao, Wenwen Yang, et al., "Inhibition of Glucose-6-Phosphate Dehydrogenase Could Enhance 1,4-Benzoquinone- ...
Monomer-Polymer & Dajac Laboratories Inc. is a manufacturer and supplier of specality monomers, speciality polyners, diagnoctic reagents, flourinated monomers, reactive surfactants, epoxy resins and oligomers and other speciality chemicals.
3,5-Di-tert-butyl-1,2-benzoquinone. e-EROS Encyclopedia of Reagents for Organic Synthesis. . ...
A related benzoquinone ansamycin that failed to revert transformed cells did not inhibit the formation of this complex. These ... 19-Substituted Benzoquinone Ansamycin Heat Shock Protein-90 Inhibitors: Biological Activity and Decreased Off-Target Toxicity ... Benzoquinone ansamycin 17AAG binds to mitochondrial voltage-dependent anion channel and inhibits cell invasion ... Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for ...
E)-2-[2-(4-Methyl-[2,2]bipyridinyl-4-yl)-vinyl]-[1,4]benzoquinone. Harald Zieg and Burkhard Koenig * ... Zieg, H.; Koenig, B. (E)-2-[2-(4-Methyl-[2,2]bipyridinyl-4-yl)-vinyl]-[1,4]benzoquinone. Molbank 2002, 2002, M276. ... Zieg H, Koenig B. (E)-2-[2-(4-Methyl-[2,2]bipyridinyl-4-yl)-vinyl]-[1,4]benzoquinone. Molbank. 2002; 2002(1):M276. ... E)-2-[2-(4-Methyl-[2,2]bipyridinyl-4-yl)-vinyl]-[1,4]benzoquinone." Molbank 2002, no. 1: M276. ...
The report generally describes para-benzoquinone(pbq), examines its uses, production methods, patents. Para-Benzoquinone(PBQ) ... Para-benzoquinone(pbq) prices in other regions. 7. PARA-BENZOQUINONE(PBQ) END-USE SECTOR 7.1. Para-benzoquinone(pbq) market by ... Para-benzoquinone(pbq) market forecast. 6. PARA-BENZOQUINONE(PBQ) MARKET PRICES. 6.1. Para-benzoquinone(pbq) prices in Europe. ... 3. PARA-BENZOQUINONE(PBQ) MANUFACTURING METHODS. 4. PARA-BENZOQUINONE(PBQ) PATENTS. Abstract. Description. Summary of the ...
Benzoquinone ansamycin (BQA) Hsp90 inhibitors such as 17-DMAG and 17-AAG have off-target toxicities in clinical trials ... Abstract 1788: 19-Substituted benzoquinone ansamycins. Hsp90 inhibitors with decreased off-target toxicity. Chuan-Hsin Chang, ... 19-Substituted benzoquinone ansamycins. Hsp90 inhibitors with decreased off-target toxicity. [abstract]. In: Proceedings of the ... Abstract 1788: 19-Substituted benzoquinone ansamycins. Hsp90 inhibitors with decreased off-target toxicity ...
Benzoquinone situation. When I first tried this I bought a 30 % H2O2 under the name Baquacil and I tried the Erowid version of ... Benzoquinone crystallizes in a platy form without inclusions.. But I dont think it matters too much. These are details that ... What are you using the Benzoquinone for? Its an MDMA precurser, but I guess you knew that. If youre interested in the science ... Apply gentle heat and from time to time add more H2O2 until all quinhydrone is converted into golden benzoquinone. Its obvious ...
2-hydroxy-3-methyl-1,4-benzoquinone. Submitted by Michael on Fri, 06/21/2013 - 12:06. ...
The combination of DDQ and NaNO2 showed high efficiency and high selectivity, compared with other benzoquinones and ... 6-dicyano-benzoquinone(DDQ) and NaNO2 with dioxygen is reported. ... 6-dicyano-benzoquinone(DDQ) and NaNO2 with dioxygen is reported ... The combination of DDQ and NaNO2 showed high efficiency and high selectivity, compared with other benzoquinones and ... Organocatalytic Oxidative Dehydrogenation of Dihydroarenes by Dioxygen Using 2,3-Dichloro-5,6-dicyano-benzoquinone (DDQ) and ...
X-irradiation of an Ar matrix doped with {\it p}-benzoquinone (PBQ) at 10 K leads to formation of the PBQ radical cation (PBQ ... MANIFESTATION OF NONADIABATIC EFFECTS IN THE IR SPECTRUM OF PARA-BENZOQUINONE RADICAL CATION. ...
0/Alkenes; 0/Allyl Compounds; 0/Benzoquinones; 0/Carboxylic Acids; 106-51-4/benzoquinone; 7440-05-3/Palladium ... Benzoquinones / chemistry*. Carboxylic Acids / chemistry*. Catalysis. Combinatorial Chemistry Techniques. Molecular Structure. ...
4-benzoquinone explanation free. What is 1,4-benzoquinone? Meaning of 1,4-benzoquinone medical term. What does 1,4-benzoquinone ... 4-benzoquinone, and 2-methoxy-3-methyl-l,4-benzoquinone (Fig.. Has vertebrate chemesthesis been a selective agent in the ... 1,4-benzoquinone. Also found in: Wikipedia. 1,4-ben·zo·qui·none. (benzō-kwinōn), 1. An essential part of coenzyme Q and ... 1,4-Benzoquinone decreased the quantum yield of HPD photobleaching at all concentrations studied (from 0.001 up to 0.25 mM) ( ...
benzoquinone ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs. ...
  • Benzoquinone (C6H4O2) is a quinone with a single benzene ring. (wikipedia.org)
  • It is one of the two isomers of quinone, the other being 1,4-benzoquinone. (wikipedia.org)
  • 1,4-Benzoquinone , commonly known as para-quinone , is a chemical compound with the formula C 6 H 4 O 2 . (sciencemadness.org)
  • An acidic potassium iodide solution reduces a solution of benzoquinone to hydroquinone , which can be reoxidized back to the quinone with a solution of silver nitrate . (sciencemadness.org)
  • Quinone (p-benzoquinone) exists as a large yellow, monoclinic prism with an irritating odour resembling that of chlorine. (chemicalbook.com)
  • Quinone (p-benzoquinone) was first produced commercially in 1919 and has since been manufactured in several European countries. (chemicalbook.com)
  • Preparation of Quinone (p-Benzoquinone) from Hydroquinone. (chemicalbook.com)
  • Chemical trapping studies combined with optical and electron paramagnetic resonance measurements were employed to examine the mechanisms of the aqueous photochemistry of methyl-benzoquinone (mBQ) at both low and high quinone concentrations. (altemagames.com)
  • Coenzyme Q10, also known as ubiquinone-10, is a 1,4-benzoquinone, where Q refers to the quinone chemical group, and 10 refers to the number of isoprenyl chemical subunits in its tail. (rcsb.org)
  • The simplest member of the class of 1,4-benzoquinones, obtained by the formal oxidation of hydroquinone to the corresponding diketone. (ebi.ac.uk)
  • Filter out the solids present in the mixture, which are hydroquinone (the degradation product of the benzoquinone) and PdCl 2 . (erowid.org)
  • Benzoquinone can be prepared by oxidation of hydroquinone . (sciencemadness.org)
  • Only until I boiled the reaction contents for a minute to a minute and a half while refluxing after I added the H2O2 wholesale did the hydroquinone go all the way to Benzoquinone after the boiling I would chill the rbf immediately in an icebath and then it would promptly go into the freezer for crystalization. (sciencemadness.org)
  • Among those peroxidases, myeloperoxidase is found with particularly high concentrations, which activates hydroquinone to 1,4-benzoquinone (1,4-BQ), a more reactive species of benzene [6]. (thefreedictionary.com)
  • Reduction of benzoquinones to hydroquinones via spontaneous reaction with glutathione and enzymatic reaction by S-glutathionyl-hydroquinone reductases. (openrepository.com)
  • Numerical simulations confirm that the coupling of the photoreduction of 1,4-benzoquinone and the autocatalytic oxidation of 1,4-hydroquinone is responsible for the observed spontaneous oscillations. (altemagames.com)
  • benzene-1,2-diol (catechol) and benzene-1,4-diol (hydroquinone), are easily oxidized to yield the corresponding quinones para-benzoquinone and ortho-benzoquinone, respectively. (altemagames.com)
  • The supported catalyst was very efficient at oxidizing hydroquinone into p ‐benzoquinone. (altemagames.com)
  • The activity of the catalysts was measured in the model reaction-oxidation of hydroquinone (H2Q) to p-benzoquinone (Q) by hydrogen peroxide (H2O2). (altemagames.com)
  • Hydroquinone and benzoquinone. (docplayer.net)
  • The substrate 1,4-benzoquinone and the product hydroquinone are positioned close to the FMN N5 in the respective crystal structures with NfsA, suitable for reaction, but are mobile within the active site. (portlandpress.com)
  • 1,2-Benzoquinone, also called ortho-benzoquinone, is an organic compound with formula C6H4O2. (wikipedia.org)
  • Formation of ortho-benzoquinone from sodium benzoate by Pseudomonas mendocina P2d" (PDF). (wikipedia.org)
  • The preparation and reactions of ortho-benzoquinone monohemiaminals are described. (elsevier.com)
  • The oxidative dearomatization of phenols bearing amino alcohol groups induced N-cyclization to afford ortho-benzoquinone monohemiaminals. (elsevier.com)
  • The chiral ortho-benzoquinone monohemiaminal undergoes stereoselective Diels-Alder reactions with electron-deficient alkenes, as expected, confirming the promising utility of ortho-benzoquinone monohemiaminals. (elsevier.com)
  • Occupational exposure to para- benzoquinone dioxime probably occurs during its manufacture, its use as a rubber vulcanizing agent and its conversion to chemical derivatives. (inchem.org)
  • 2. One of a class of benzoquinone derivatives. (thefreedictionary.com)
  • The benzoquinone ansamycin Hsp90 inhibitors geldanamycin and/or its derivatives 17-allylamino-17-demethoxygeldanamycin (17-AAG) and 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin inhibited production of vascular endothelial growth factor (VEGF)-A by tumor cells and blocked proliferative responses of human endothelial cells at nanomolar concentrations. (aacrjournals.org)
  • Since our commencement in the year 1993, we are considered as the foremost manufacturer, exporter and supplier of Para Benzoquinone Derivatives. (gajananenterprises.co.in)
  • In addition to this, clients can avail the offered Para Benzoquinone Derivatives from us at industry leading prices. (gajananenterprises.co.in)
  • Conversion of pentahalogenated phenols by microperoxidase-8/h202 to benzoquinone type products. (wur.nl)
  • This learning unit explains the mechanism of the oxidation of phenols to benzoquinones. (chemgapedia.de)
  • ChemInform Abstract: A Convenient Synthesis of Alkyl Substituted p-Benzoquinones from Phenols and H2O2 over TiAPO-5 Molecular Sieve Catalyst. (scite.ai)
  • N-acetyl-p-benzoquinone imine (NAPQI) has been proposed as the toxic metabolite of acetaminophen for the past 10 years, although it has never been detected as an enzymatic oxidation product of acetaminophen. (pnas.org)
  • Furthermore, as a measurement of potential hepatotoxicity, the molar dose fraction of acetaminophen converted to N-acetyl-p-benzoquinone imine (NAPQI) was estimated. (eur.nl)
  • 1] have reported the synthesis of a compound similar to 2 , which has a saturated ethano bridged between the 2,2'-bipyridine and the para-benzoquinone moiety. (mdpi.com)
  • Nikitina, A. 2004-10-13 00:00:00 A procedure was developed for synthesis of a new monomer from monoethanolamine vinyl ether and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone. (deepdyve.com)
  • Synthesis and structural elucidation of various glutathione addition products to 1,4-benzoquinone. (openrepository.com)
  • The benzoquinones of the invention have various potential applications in pharmaceutical and cosmetic industry (namely as antioxidants, anti-ageing agents and the like), in organic synthesis, metal complexations, metal separations, potentiometric titrations, interfacial catalysis, and ion-transfer reactions across biological membranes. (edu.mk)
  • Regioselective Synthesis of Bicyclic and Polycyclic Systems by Cycloaddition Reactions of Alkenyl p-Benzoquinones. (nih.gov)
  • A related benzoquinone ansamycin that failed to revert transformed cells did not inhibit the formation of this complex. (pnas.org)
  • Benzoquinone ansamycin (BQA) Hsp90 inhibitors such as 17-DMAG and 17-AAG have off-target toxicities in clinical trials including hepatotoxicity. (aacrjournals.org)
  • Reactions of glutathione and glutathione radicals with benzoquinones. (openrepository.com)
  • The reactions of glutathione (GSH) and glutathione radicals with a series of methyl-substituted 1,4-benzoquinones and 1,4-benzoquinone have been studied. (openrepository.com)
  • It was found that by mixing excess benzoquinone with glutathione at pH above 6.5, the products formed were complex and unstable. (openrepository.com)
  • Reductive addition of glutathione to p-benzoquinone, 2-hydroxy-p-benzoquinone, and p-benzoquinone epoxides. (openrepository.com)
  • The first objective of this study was to determine if exposure of fetal hematopoietic cells to p-benzoquinone, a known toxic metabolite of benzene, increased DNA recombination in the pKZ1 model of mutagenesis. (queensu.ca)
  • 1,2-Benzoquinone is produced on oxidation of catechol exposed to air in aqueous solution or by ortho oxidation of a phenol. (wikipedia.org)
  • A strain of the bacterium Pseudomonas mendocina metabolises benzoic acid, yielding 1,2-benzoquinone via catechol. (wikipedia.org)
  • Unsubstituted zinc phthalocyanine, 1, 3-diphenylisobenzofuran (DPBF), and 1,4-benzoquinone (BQ) were purchased from Sigma Aldrich. (thefreedictionary.com)
  • Using cyclic voltammetry, the electrochemistry of aqueous solutions of 4-methoxy-1,2-benzoquinone was investigated over the pH range 0-8. (edu.au)
  • The production of these benzoquinones comprises the reaction of dimethoxy benzoquinones with highly alkaline aqueous solutions. (edu.mk)
  • Inhibition of Glucose-6-Phosphate Dehydrogenase Could Enhance 1,4-Benzoquinone-Induced Oxidative Damage in K562 Cells," Oxidative Medicine and Cellular Longevity , vol. 2016, Article ID 3912515, 11 pages, 2016. (hindawi.com)
  • Secondly, this study determined if exposure of fetal hematopoietic cells to p-benzoquinone resulted in DNA damage using γ-H2A.X as a marker for DNA double strand breaks and 8-hydroxy-2'-deoxyguanosine as a marker of oxidative DNA damage. (queensu.ca)
  • Exposure of fetal hematopoietic cells to 25 μM p-benzoquinone did not significantly increase oxidative DNA damage at any of the examined time points. (queensu.ca)
  • These studies indicate that p-benzoquinone is able to induce DNA damage and recombination in fetal hematopoieitic cells and that reactive oxygen species and oxidative stress may be important in the mechanism of toxicity. (queensu.ca)
  • Efficient oxidative carbonylation of iPrOH to oxalate catalyzed by Pd(II)-PPh3 complexes using benzoquinone as a stoichiometric oxidant. (altemagames.com)
  • The presence of considerable quantities of hydroquinones and hydrocarbons, which are typically present in the secretions of most other arthropods that use benzoquinones as repellents, are notably absent in the secretion of A. setigerus. (semanticscholar.org)
  • It was observed that simple hydroquinones were not formed when the different benzoquinones were mixed with excess GSH and suggests that the initial reaction is addition/reduction rather than electron transfer. (openrepository.com)
  • The regioselectivity of the reaction of conjugate addition of thiols amines, methanol and hydrogen chloride with the monoalkyl-1,4-benzoquinones avarone and 2-tert-butyl- 1,4-benzoquinone was investigated. (ac.rs)
  • TY - JOUR AU - Božić, Tatjana T. AU - Sladić, Dušan AU - Zlatović, Mario AU - Novaković, Irena AU - Trifunović, Snežana AU - Gašić, Miroslav J. PY - 2002 UR - http://cer.ihtm.bg.ac.rs/handle/123456789/55 AB - The regioselectivity of the reaction of conjugate addition of thiols amines, methanol and hydrogen chloride with the monoalkyl-1,4-benzoquinones avarone and 2-tert-butyl- 1,4-benzoquinone was investigated. (ac.rs)
  • There is limited evidence that para- benzoquinone dioxime is carcinogenic to rats. (inchem.org)
  • Benzoquinone is probably carcinogenic. (sciencemadness.org)
  • We are counted as a leading Manufacturer, Exporter and Supplier of reliable industrial chemical like P-Benzoquinone, Para Benzoquinone, etc . (gajananenterprises.co.in)
  • ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. Note: Ethylene and Cyclohexene Oxidation by p-Benzoquinone, Hydrogen Peroxide, and Oxygen in the Solutions of Cationic Pd(II) Complexes in Acetonitrile-Water and Ionic Liquid-Water Binary Solvents. (altemagames.com)
  • 1,4-Benzoquinone or p-benzoquinone is the basic structure of quinonoid compounds.They are widely distributed in the natural world, being found in bacteria, plants and arthropods and hence quinones are ubiquitous to living systems. (chemicalbook.com)
  • To elucidate the impact of benzoquinone (BQ) on lipid homeostasis and cytotoxicity in Saccharomyces cerevisiae . (rsc.org)
  • Sorghum bicolor is considered to be an allelopathic crop species, producing phytotoxins such as the lipid benzoquinone sorgoleone, which likely accounts for many of the allelopathic properties of Sorghum spp. (plantcell.org)
  • Benzoquinone readily undergoes sublimation, even at room temperature. (sciencemadness.org)
  • 1,4-Benzoquinone is sensitive toward both strong mineral acids and alkali, which cause condensation and decomposition of the compound. (sciencemadness.org)
  • These were shown to be due to 2-hydroxy-1,4-benzoquinone, formed by hydrolysis of the original compound. (edu.au)
  • Herbimycin A, geldanamycin, and certain other benzoquinone ansamycins display an unusual capacity to revert tyrosine kinase-induced oncogenic transformation. (pnas.org)
  • The interaction of the excited states of aromatic molecules with benzoquinones is of great interest because the latter act as electron acceptors in a number of photobiological processes 7 ) . (conicyt.cl)
  • Our collection of P-Benzoquinone, Para Benzoquinone, etc is a yellow to green crystal in solid form with pungent odor and significant vapor pressure. (gajananenterprises.co.in)
  • The invention relates to a new type of highly polar, at least double-negatively charged redox-active benzoquinones, notably derived from Coenzyme Q0, Q1 and dimethoxy benzoquinones, its production and use. (edu.mk)
  • Photocatalytic degradation of 1,4-Benzoquinone in aqueous ZnO dispersions," Journal of the Brazilian Chemical Society, vol. (thefreedictionary.com)
  • To determine which metabolites of arachidonic acid stimulated the release of β-end-IR, we examined the effects of an inhibitor of the cyclooxygenase, indomethacin, and an inhibitor of the 5-lipoxygenase, 2,3,5- trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-l,4-benzoquinone . (acronymattic.com)
  • I am thinking about just buying another gallon of Baquacil because I keep thinking that I strengthened it greatly with the fridge and all that has resulted is no Benzoquinone and not even any Quinhydrone just a purply liquid that seems almost scorched. (sciencemadness.org)
  • A significant increase in γ-H2A.X foci formation was observed following exposure to 25 μM p-benzoquinone for 30 min, 45 min and one hour. (queensu.ca)
  • Hartre-Fock calculations showed that the anion negative charge was located mostl Показать полностью y on the oxygen of hydroxyl group, while estimation of the total energy of the alkylated products pointed out the benefit of alkylation on the oxygen atom of the nitroso group yielding p-benzoquinone monoxime alkyl ethers. (sfu-kras.ru)
  • In this study, the poly-vinylidene fluoride (PVDF)/p-benzoquinone (pBQ) gel polymer electrolyte (GPE) is synthesized well with LiTFSI/TEGDME for Li-Air battery (LAB) applications. (elsevier.com)
  • The disodium salt of 2,5-dihydroxy-1,4-benzoquinone has been prepared and proposed as anode material for rechargeable sodium ion batteries for the first time, showing an average operation voltage of ∼1.2 V, a reversible capacity of ∼265 mA h g −1 , a long cycle life (300 cycles), and high rate capability. (rsc.org)
  • Pd(O2CCF3)2/benzoquinone: a versatile catalyst system for the decarboxylative olefination of arene carboxylic acids. (biomedsearch.com)
  • para- Benzoquinone dioxime was tested for carcinogenicity at two dose levels in mice and rats by oral administration. (inchem.org)
  • Stats And Reports has added a new Global Benzoquinone Market Study that scrutinizes current scenarios for future market size, market share, demand, growth, trends and forecasts. (tristateobserver.com)
  • Here we present an investigation of the quenching of anthracene triplet by several p-benzoquinones, in two solvents of nearly equal macroscopic dielectric properties, methanol and acetonitrile. (conicyt.cl)
  • In order to obtain a further insight on the solvent effect on bimolecular PET rate constants, we present here an investigation of the quenching of anthracene triplet by several p-benzoquinones, in two solvents of nearly equal macroscopic dielectric properties, methanol and acetonitrile. (conicyt.cl)
  • The hydrolysis reaction was shown to be first order both with respect to the 1,2-benzoquinone and protons. (edu.au)
  • It is proposed that anointing combined with the ingestion of millipedes' benzoquinone secretions by red-fronted lemurs may act in a complementary fashion against gastrointestinal parasite infections, and more specifically Oxyuridae nematodes, providing both prophylactic and therapeutic effects. (semanticscholar.org)
  • Department of Occupational en Environmental Dermatology, University Hospital, S-205 02 Malmö. (springer.com)
  • Coenzyme Q10 (or 1,4-benzoquinone ) is a component of the electron transport chain in mitochondria which is linked to the generation of energy in the cell (Bentinger et al. (thefreedictionary.com)
  • Excited-state electron and energy transfer from singlet excited rubrene (Ru) to benzoquinone (BQ) and tetra-(4-aminophenyl) porphyrin (TAPP) were investigated by steady-state absorption and emission, time-resolved transient absorption, and femtosecond (fs)-nanosecond (ns) fluorescence spectroscopy. (edu.sa)