Benzene rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.
A quinone fungicide used for treatment of seeds and foliage.
Saturated azacyclopropane compounds. They include compounds with substitutions on CARBON or NITROGEN atoms.
Hydrocarbon rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.
A lipid-soluble benzoquinone which is involved in ELECTRON TRANSPORT in mitochondrial preparations. The compound occurs in the majority of aerobic organisms, from bacteria to higher plants and animals.
LACTAMS forming compounds with a ring size of approximately 1-3 dozen atoms.
Toxic, volatile, flammable liquid hydrocarbon byproduct of coal distillation. It is used as an industrial solvent in paints, varnishes, lacquer thinners, gasoline, etc. Benzene causes central nervous system damage acutely and bone marrow damage chronically and is carcinogenic. It was formerly used as parasiticide.
A flavoprotein that reversibly catalyzes the oxidation of NADH or NADPH by various quinones and oxidation-reduction dyes. The enzyme is inhibited by dicoumarol, capsaicin, and caffeine.
A class of Arthropoda that includes SPIDERS; TICKS; MITES; and SCORPIONS.
Unsaturated azacyclopropane compounds that are three-membered heterocycles of a nitrogen and two carbon atoms.
An experimental lymphocytic leukemia of mice.
Alkylating antineoplastic agent used mainly for ovarian tumors. It is toxic to skin, gastrointestinal tract, bone marrow and kidneys.
Compounds consisting of benzene rings linked to each other in either ortho, meta or para positions. Permitted are any substitutions, but ring fusion to any of the benzene rings is not allowed.
A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients.
Alkylating anti-neoplastic agent.
A class of MOLECULAR CHAPERONES whose members act in the mechanism of SIGNAL TRANSDUCTION by STEROID RECEPTORS.
A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).
Synthetic organic reactions that use reactions between unsaturated molecules to form cyclical products.
NAD(P)H:(quinone acceptor) oxidoreductases. A family that includes three enzymes which are distinguished by their sensitivity to various inhibitors. EC 1.6.99.2 (NAD(P)H DEHYDROGENASE (QUINONE);) is a flavoprotein which reduces various quinones in the presence of NADH or NADPH and is inhibited by dicoumarol. EC 1.6.99.5 (NADH dehydrogenase (quinone)) requires NADH, is inhibited by AMP and 2,4-dinitrophenol but not by dicoumarol or folic acid derivatives. EC 1.6.99.6 (NADPH dehydrogenase (quinone)) requires NADPH and is inhibited by dicoumarol and folic acid derivatives but not by 2,4-dinitrophenol.
An oral anticoagulant that interferes with the metabolism of vitamin K. It is also used in biochemical experiments as an inhibitor of reductases.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
Metals that constitute the group 2 (formerly group IIa) of the periodic table.
A phylum of fungi that produce their sexual spores (basidiospores) on the outside of the basidium. It includes forms commonly known as mushrooms, boletes, puffballs, earthstars, stinkhorns, bird's-nest fungi, jelly fungi, bracket or shelf fungi, and rust and smut fungi.
A plant genus of the family POACEAE. The grain is used for FOOD and for ANIMAL FEED. This should not be confused with KAFFIR LIME or with KEFIR milk product.
Naphthalene rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.
A family of bracket fungi, order POLYPORALES, living in decaying plant matter and timber.
Six-carbon alicyclic hydrocarbons.
The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
The covalent bonding of an alkyl group to an organic compound. It can occur by a simple addition reaction or by substitution of another functional group.
A species of gram-positive, spherical bacteria whose organisms occur in tetrads and in irregular clusters of tetrads. The primary habitat is mammalian skin.
A group of 1,2-benzenediols that contain the general formula R-C6H5O2.
A flavoprotein oxidase complex that contains iron-sulfur centers. It catalyzes the oxidation of SUCCINATE to fumarate and couples the reaction to the reduction of UBIQUINONE to ubiquinol.
An alkylating sulfhydryl reagent. Its actions are similar to those of iodoacetate.
A flavoprotein containing oxidoreductase that catalyzes the dehydrogenation of SUCCINATE to fumarate. In most eukaryotic organisms this enzyme is a component of mitochondrial electron transport complex II.
The class of all enzymes catalyzing oxidoreduction reactions. The substrate that is oxidized is regarded as a hydrogen donor. The systematic name is based on donor:acceptor oxidoreductase. The recommended name will be dehydrogenase, wherever this is possible; as an alternative, reductase can be used. Oxidase is only used in cases where O2 is the acceptor. (Enzyme Nomenclature, 1992, p9)
The art or process of comparing photometrically the relative intensities of the light in different parts of the spectrum.
Benzene derivatives that include one or more hydroxyl groups attached to the ring structure.
An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.
A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.
Large enzyme complexes composed of a number of component enzymes that are found in STREPTOMYCES which biosynthesize MACROLIDES and other polyketides.
Highly reactive chemicals that introduce alkyl radicals into biologically active molecules and thereby prevent their proper functioning. Many are used as antineoplastic agents, but most are very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. They have also been used as components in poison gases.
The rate dynamics in chemical or physical systems.
The process by which ELECTRONS are transported from a reduced substrate to molecular OXYGEN. (From Bennington, Saunders Dictionary and Encyclopedia of Laboratory Medicine and Technology, 1984, p270)
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).
Substances that inhibit or prevent the proliferation of NEOPLASMS.
Highly reactive molecules with an unsatisfied electron valence pair. Free radicals are produced in both normal and pathological processes. They are proven or suspected agents of tissue damage in a wide variety of circumstances including radiation, damage from environment chemicals, and aging. Natural and pharmacological prevention of free radical damage is being actively investigated.
Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
Determination of the spectra of ultraviolet absorption by specific molecules in gases or liquids, for example Cl2, SO2, NO2, CS2, ozone, mercury vapor, and various unsaturated compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A transferase that catalyzes the addition of aliphatic, aromatic, or heterocyclic FREE RADICALS as well as EPOXIDES and arene oxides to GLUTATHIONE. Addition takes place at the SULFUR. It also catalyzes the reduction of polyol nitrate by glutathione to polyol and nitrite.
A subclass of enzymes of the transferase class that catalyze the transfer of a methyl group from one compound to another. (Dorland, 28th ed) EC 2.1.1.
The measurement of the amplitude of the components of a complex waveform throughout the frequency range of the waveform. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
A technique applicable to the wide variety of substances which exhibit paramagnetism because of the magnetic moments of unpaired electrons. The spectra are useful for detection and identification, for determination of electron structure, for study of interactions between molecules, and for measurement of nuclear spins and moments. (From McGraw-Hill Encyclopedia of Science and Technology, 7th edition) Electron nuclear double resonance (ENDOR) spectroscopy is a variant of the technique which can give enhanced resolution. Electron spin resonance analysis can now be used in vivo, including imaging applications such as MAGNETIC RESONANCE IMAGING.
Systems of enzymes which function sequentially by catalyzing consecutive reactions linked by common metabolic intermediates. They may involve simply a transfer of water molecules or hydrogen atoms and may be associated with large supramolecular structures such as MITOCHONDRIA or RIBOSOMES.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms.
A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.

p50(cdc37) acting in concert with Hsp90 is required for Raf-1 function. (1/2081)

Genetic screens in Drosophila have identified p50(cdc37) to be an essential component of the sevenless receptor/mitogen-activated kinase protein (MAPK) signaling pathway, but neither the function nor the target of p50(cdc37) in this pathway has been defined. In this study, we examined the role of p50(cdc37) and its Hsp90 chaperone partner in Raf/Mek/MAPK signaling biochemically. We found that coexpression of wild-type p50(cdc37) with Raf-1 resulted in robust and dose-dependent activation of Raf-1 in Sf9 cells. In addition, p50(cdc37) greatly potentiated v-Src-mediated Raf-1 activation. Moreover, we found that p50(cdc37) is the primary determinant of Hsp90 recruitment to Raf-1. Overexpression of a p50(cdc37) mutant which is unable to recruit Hsp90 into the Raf-1 complex inhibited Raf-1 and MAPK activation by growth factors. Similarly, pretreatment with geldanamycin (GA), an Hsp90-specific inhibitor, prevented both the association of Raf-1 with the p50(cdc37)-Hsp90 heterodimer and Raf-1 kinase activation by serum. Activation of Raf-1 via baculovirus coexpression with oncogenic Src or Ras in Sf9 cells was also strongly inhibited by dominant negative p50(cdc37) or by GA. Thus, formation of a ternary Raf-1-p50(cdc37)-Hsp90 complex is crucial for Raf-1 activity and MAPK pathway signaling. These results provide the first biochemical evidence for the requirement of the p50(cdc37)-Hsp90 complex in protein kinase regulation and for Raf-1 function in particular.  (+info)

Salmonella typhimurium and lipopolysaccharide stimulate extracellularly regulated kinase activation in macrophages by a mechanism involving phosphatidylinositol 3-kinase and phospholipase D as novel intermediates. (2/2081)

Activation of the extracellularly regulated kinase (ERK) pathway is part of the early biochemical events that follow lipopolysaccharide (LPS) treatment of macrophages or their infection by virulent and attenuated Salmonella strains. Phagocytosis as well as the secretion of invasion-associated proteins is dispensable for ERK activation by the pathogen. Furthermore, the pathways used by Salmonella and LPS to stimulate ERK are identical, suggesting that kinase activation might be solely mediated by LPS. Both stimuli activate ERK by a mechanism involving herbimycin-dependent tyrosine kinase(s) and phosphatidylinositol 3-kinase. Phospholipase D activation and stimulation of protein kinase C appear to be intermediates in this novel pathway of MEK/ERK activation.  (+info)

Involvement of tyrosine phosphorylation in HMG-CoA reductase inhibitor-induced cell death in L6 myoblasts. (3/2081)

Our previous studies have shown that the HMG-CoA reductase (HCR) inhibitor (HCRI), simvastatin, causes myopathy in rabbits and kills L6 myoblasts. The present study was designed to elucidate the molecular mechanism of HCRI-induced cell death. We have demonstrated that simvastatin induces the tyrosine phosphorylation of several cellular proteins within 10 min. These phosphorylations were followed by apoptosis, as evidenced by the occurrence of internucleosomal DNA fragmentation and by morphological changes detected with Nomarski optics. Simvastatin-induced cell death was prevented by tyrosine kinase inhibitors. The MTT assay revealed that the addition of mevalonic acid into the culture medium partially inhibited simvastatin-induced cell death. Thus, these results suggested that protein tyrosine phosphorylation might play an important role in the intracellular signal transduction pathway mediating the HCRI-induced death of myoblasts.  (+info)

Role of a novel photosystem II-associated carbonic anhydrase in photosynthetic carbon assimilation in Chlamydomonas reinhardtii. (4/2081)

Intracellular carbonic anhydrases (CA) in aquatic photosynthetic organisms are involved in the CO2-concentrating mechanism (CCM), which helps to overcome CO2 limitation in the environment. In the green alga Chlamydomonas reinhardtii, this CCM is initiated and maintained by the pH gradient created across the chloroplast thylakoid membranes by photosystem (PS) II-mediated electron transport. We show here that photosynthesis is stimulated by a novel, intracellular alpha-CA bound to the chloroplast thylakoids. It is associated with PSII on the lumenal side of the thylakoid membranes. We demonstrate that PSII in association with this lumenal CA operates to provide an ample flux of CO2 for carboxylation.  (+info)

Inactivation of both RNA binding and aconitase activities of iron regulatory protein-1 by quinone-induced oxidative stress. (5/2081)

Iron regulatory protein-1 (IRP-1) controls the expression of several mRNAs by binding to iron-responsive elements (IREs) in their untranslated regions. In iron-replete cells, a 4Fe-4S cluster converts IRP-1 to cytoplasmic aconitase. IRE binding activity is restored by cluster loss in response to iron starvation, NO, or extracellular H2O2. Here, we study the effects of intracellular quinone-induced oxidative stress on IRP-1. Treatment of murine B6 fibroblasts with menadione sodium bisulfite (MSB), a redox cycling drug, causes a modest activation of IRP-1 to bind to IREs within 15-30 min. However, IRE binding drops to basal levels within 60 min. Surprisingly, a remarkable loss of both IRE binding and aconitase activities of IRP-1 follows treatment with MSB for 1-2 h. These effects do not result from alterations in IRP-1 half-life, can be antagonized by the antioxidant N-acetylcysteine, and regulate IRE-containing mRNAs; the capacity of iron-starved MSB-treated cells to increase transferrin receptor mRNA levels is inhibited, and MSB increases the translation of a human growth hormone indicator mRNA bearing an IRE in its 5'-untranslated region. Nonetheless, MSB inhibits ferritin synthesis. Thus, menadione-induced oxidative stress leads to post-translational inactivation of both genetic and enzymatic functions of IRP-1 by a mechanism that lies beyond the "classical" Fe-S cluster switch and exerts multiple effects on cellular iron metabolism.  (+info)

Stimulation of ultraviolet-induced apoptosis of human fibroblast UVr-1 cells by tyrosine kinase inhibitors. (6/2081)

Damnacanthal is an anthraquinone compound isolated from the root of Morinda citrifolia and was reported to have a potent inhibitory activity towards tyrosine kinases such as Lck, Src, Lyn and EGF receptor. In the present study, we have examined the effects of damnacanthal on ultraviolet ray-induced apoptosis in ultraviolet-resistant human UVr-1 cells. When the cells were treated with damnacanthal prior to ultraviolet irradiation, DNA fragmentation was more pronounced as compared to the case of ultraviolet irradiation alone. The other tyrosine kinase inhibitors, herbimycin A and genistein, also caused similar effects on ultraviolet-induced apoptosis but to a lesser extent. Serine/threonine kinase inhibitors, K252a, staurosporine and GF109203X, rather suppressed the ultraviolet-induced DNA cleavage. Immunoblot analysis showed that pretreatment with damnacanthal followed by ultraviolet irradiation increased the levels of phosphorylated extracellular signal-regulated kinases and stress-activated protein kinases. However, the other tyrosine kinase inhibitors did not increase the phosphorylation of extracellular signal-regulated kinases but stimulated phosphorylation of stress-activated protein kinases. Consequently, the ultraviolet-induced concurrent increase in both phosphorylated extracellular signal-regulated kinases and stress-activated protein kinases after pretreatment with damnacanthal might be characteristically related to the stimulatory effect of damnacanthal on ultraviolet-induced apoptosis.  (+info)

Effects of pyrogallol, hydroquinone and duroquinone on responses to nitrergic nerve stimulation and NO in the rat anococcygeus muscle. (7/2081)

1. The hypothesis that endogenous superoxide dismutase (SOD) protects the nitrergic transmitter from inactivation by superoxide and that this explains the lack of sensitivity of the transmitter to superoxide generators was tested in the rat isolated anococcygeus muscle. 2. Responses to nitrergic nerve stimulation or to NO were not significantly affected by exogenous SOD or by the Cu/Zn SOD inhibitor diethyldithiocarbamic acid (DETCA). 3. Hydroquinone produced a concentration-dependent reduction of responses to NO with an IC50 of 27 microM, and higher concentrations reduced relaxant responses to nitrergic nerve stimulation with an IC50 of 612 microM. The effects of hydroquinone were only slightly reversed by SOD, so it does not appear to be acting as a superoxide generator. 4. Pyrogallol produced a concentration-dependent reduction in responses to NO with an IC50 value of 39 microM and this effect was reversed by SOD (100-1000 u ml(-1)). Pyrogallol did not affect responses to nitrergic nerve stimulation. Treatment with DETCA did not alter the differentiating action of pyrogallol. 5. Duroquinone produced a concentration-dependent reduction of relaxations to NO with an IC50 value of 240 microM and 100 microM slightly decreased nitrergic relaxations. After treatment with DETCA, duroquinone produced greater reductions of relaxant responses to NO and to nitrergic stimulation, the IC50 values being 8.5 microM for NO and 40 microM for nitrergic nerve stimulation: these reductions were reversed by SOD. 6. The findings do not support the hypothesis that the presence of Cu/Zn SOD explains the greater susceptibility of NO than the nitrergic transmitter to the superoxide generator pyrogallol, but suggest that it may play a role in the effects of duroquinone.  (+info)

Tyrosine kinase-dependent modulation by interferon-alpha of the ATP-sensitive K+ current in rabbit ventricular myocytes. (8/2081)

We examined the effects of interferon-alpha on the ATP-sensitive K+ current (IK,ATP) in rabbit ventricular cells using the patch-clamp technique. IK,ATP was induced by NaCN. Whole-cell experiments indicated that interferon-alpha (5 x 10(2) - 2.4 x 10(4) U/ml) inhibited IK,ATP in a concentration-dependent manner (60.7+/-7.5% with 2.4 x 10(4) U/ml). In cell-attached configuration, interferon-alpha (2.4 x 10(4) U/ml) applied to the external solution also inhibited the activity of the single ATP-sensitive K+ (KATP) channel by 56.0+/-5.8% without affecting the single channel conductance. The inhibitory effect of IK,ATP by interferon-alpha was blocked by genistein and herbimycin A, tyrosine kinase inhibitors, but was not affected by N-(2-metylpiperazyl)-5-isoquinolinesulfoamide (H-7), an inhibitor of protein kinase C and cAMP-dependent protein kinase. These findings suggest that interferon-alpha inhibits the cardiac KATP channel through the activation of tyrosine kinase. The tyrosine kinase-mediated inhibition of IK,ATP by cytokines may aggravate cell damage during myocardial ischemia.  (+info)

Product Details of P-Benzoquinone CAS 106-51-4 Benzoquinone p-Benzoquinone P-quinone PBQ Quinone, P-Benzoquinone CAS 106-51-4 Benzoquinone p-Benzoquinone P-quinone PBQ Quinone from China manufacturer on Hisupplier.com.
Using cyclic voltammetry, the electrochemistry of aqueous solutions of 4-methoxy-1,2-benzoquinone was investigated over the pH range 0-8. From the variation of half-wave potential with pH, it was inferred that the quinone was reduced to the hydroquinone; no acid-base reactions involving either the quinone or hydroquinone were observed. At low pH ( , 3), the cyclic voltammogram of the benzoquinone changed rapidly to a second pair of peaks at lower potentials. These were shown to be due to 2-hydroxy-1,4-benzoquinone, formed by hydrolysis of the original compound. The other hydrolysis product, methanol, was detected chromatographically. The hydrolysis reaction was shown to be first order both with respect to the 1,2-benzoquinone and protons. At pH 6 and above, 4-methoxy-1,2-benzoquinone showed a second type of decomposition whose rate was approximately first order in hydroxide ion. Using electrochemical and spectroscopic measurements, it was also demonstrated that 4-methoxy-1,2-benzoquinone was ...
The invention relates to benzoquinone ansamycin analogs useful for the treatment of cancer and other diseases or conditions characterized by undesired cellular proliferation or hyperproliferation. Therapies involving the administration of such benzoquinone ansamycin analogs, optionally in combination with an inhibitor of an HSP90 client protein, are useful to treat cancer and non-cancerous disease conditions.
Seratrodast (development name, AA-2414; marketed originally as Bronica) is a thromboxane A2 (TXA2) receptor (TP receptor) antagonist used primarily in the treatment of asthma. It was the first TP receptor antagonist that was developed as an anti-asthmatic drug and received marketing approval in Japan in 1997. As of 2017 seratrodast was marketed as Bronica in Japan, and as Changnuo, Mai Xu Jia, Quan Kang Nuo in China. Unlike thromboxane synthase inhibitors such as ozagrel, seratrodast does not affect thrombus formation, time to occlusion and bleeding time. Seratrodast has no effect on prothrombin time and activated partial thromboplastin time, thus ruling out any action on blood coagulation cascade. Seratrodast is used to treat asthma. There are no adequate and well-controlled studies of seratrodast in pregnant women. The drug should be used in pregnancy only if the potential benefits justify the risk to the fetus. Seratrodast should not be used during lactation. The safety and efficacy of ...
Alfa Aesar™ 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone, 98+% 10g Alfa Aesar™ 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone, 98+% Dichlorotol to...
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1,4-Benzoquinone 常見於的活性的結構分子中,亦被廣泛地運用在藥物結構修飾。 在化學反應上,1,4-benzoquinone 較常進行的是親核基取代反應,藉由這一類的反應能 導入不同的基團,經常能提升化合物的生物活性。然而,此類的親核基取代反應對於 取代在 C2或 C3位置,並無太大的選擇性。為了提高化學選擇性、清楚了解取代基位 置對於生物活性的影響,本計畫將以兩類具 1,4-benzoquinone結構的 quinoline-5,8-dione 及天然物 denbinobin 作為探討對象,利用離去基導向、溫度控制及路易士酸輔助等方 法,提高親核基取代反應的位向選擇性,合成一系列的 2-aroyl-quinoline-5,8-dione 及 denbinobin 衍生物,初步的實驗數據顯示 2-aroyl-quinoline-5,8-dione 及 denbinobin 衍生 物接具有良好的癌細胞生長抑制效果,因此本計畫將持續探討不同取代基對於活性的 影響,同時計畫合成各式 ...
TY - JOUR. T1 - Disruption of the EF-2 kinase/Hsp90 protein complex. T2 - A possible mechanism to inhibit glioblastoma by geldanamycin. AU - Yang, Jun. AU - Yang, Jin Ming. AU - Iannone, Marie. AU - Shih, Weichung Joe. AU - Lin, Yong. AU - Hait, William N.. PY - 2001/5/15. Y1 - 2001/5/15. N2 - Glioblastoma multiforme is the most treatment-resistant brain tumor. Elongation factor-2 (EF-2) kinase (calmodulin kinase III) is a unique protein kinase that is overexpressed in glioma cell lines and in human surgical specimens. Several mitogens activate this kinase and inhibitors block mitogen activation and produce cell death. Geldanamycin (GA) is a benzoquinone ansamycin antibiotic that disrupts Hsp90-protein interactions. Because EF-2 kinase is chaperoned by Hsp90, we investigated the effects of GA on the viability of glioma cells, the expression of EF-2 kinase protein, and the interaction between Hsp90 and EF-2 kinase. GA was a potent inhibitor of the clonogenicity of four glioma cells lines with ...
TY - JOUR. T1 - Poly-vinylidene-fluoride/p-benzoquinone gel polymer electrolyte with good performance by redox mediator effect for Li-Air battery. AU - Kim, Young Bok. AU - Kim, Il To. AU - Song, Myeong Jun. AU - Shin, Moo Whan. PY - 2016/8/20. Y1 - 2016/8/20. N2 - In this study, the poly-vinylidene fluoride (PVDF)/p-benzoquinone (pBQ) gel polymer electrolyte (GPE) is synthesized well with LiTFSI/TEGDME for Li-Air battery (LAB) applications. The PVDF/pBQ GPEs are characterized by electrochemical analysis and compared to the PVDF GPE. We confirm that pBQ molecule in PVDF GPE shows redox mediate behavior during charge-discharge process. Employing PVDF/pBQ GPE for LAB leads to an improved cycleability from 2 to over 30. In addition it results in a charge voltage decrease from around 4.2 V to around 3.3 V. The energy cycle efficiency (ECE) is improved about 15%. The pBQ accelerates to the formation of an amorphous phase on synthesized PVDF GPE matrix by acting inhibitor for polymerization. It leads ...
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Studies with four benzoquinones, viz. juglone, embelin, maesaquinone and maesanin, on rat liver mitochondria oxidative phosphorylation have been carried out. Three of the benzoquinones are uncouplers in the order juglone , maesoquinone , embelin, while maesanin is an inhibitor of electron transport and oxidative phosphorylation ...
J. O. Midiwo, A. Yenesew, B. F. Juma, S. Dereses, J. A. Ayoo, A. Aluoch and S. Guchu There are several described medicinal plants in Kenya from a flora of approximately 10,000 members. Strong cross-medical information from the 42 ethnic groups points to the high potential of some of these species. The Myrsinaceae are well established ethno-anthelmintics and anti-bacterials. They are harbingers of long alkyl side chain benzoquinones which clearly have a protective function from their histochemical disposition. The main benzoquinone in the sub-family Myrsinodae is embelin while for the Maesodae it is maesaquinone together with its 5-acetyl derivative; the distribution of these benzoquinones by their alkyl side chain length or the presence/absence of a 6-methyl group is in accord with morphological sub-family de-limitation. The benzoquinones showed anti-feedant, anti-microbial, phytotoxic, acaricidal, insecticidal and nematicidal activity. Many other benzoquinones of medium and minor concentration ...
Benzoquinone ansamycin (BQA) Hsp90 inhibitors such as 17-DMAG and 17-AAG have off-target toxicities in clinical trials including hepatotoxicity. Mechanisms underlying the toxicity of quinones are a function of their ability to redox cycle and/or arylate cellular nucleophiles at the unsubstituted 19-position of the molecule. Therefore, we designed 19-substituted BQAs to prevent glutathione conjugation and non-specific interactions with protein thiols as an approach to reduce the hepatotoxicity and minimize off-target effects of the BQA class of Hsp90 inhibitors. In this study, the results showed that 19-substituted BQAs did not react with glutathione at the 19-position, while marked reactivity was observed using parent BQAs. Importantly, while parent 17-DMAG induced cell death in primary and cultured mouse hepatocytes, 19-phenyl and 19-methyl 17-DMAG showed reduced toxicity, validating the overall approach. There was no significant difference between the redox cycling ability of either 19-phenyl ...
Creative-Proteomics offer cas 106-51-4 1,4-BENZOQUINONE (D4, 98%). We are specialized in manufacturing Stabel Isotope Labeled Analytical Standard products.
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OUTLINE: This is a single-center, dose-escalation study.. Patients receive 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) IV over 1-2 hour on days 1 and 4 or days 2 and 5 weekly for 4 weeks. Treatment repeats every 4 weeks in the absence of disease progression or unacceptable toxicity.. Cohorts of 1-6 patients receive escalating doses of 17-DMAG until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2 of up to 6 patients experience dose-limiting toxicity. Once the MTD is determined, 10 additional patients are treated at the MTD.. PROJECTED ACCRUAL: Approximately 40 patients will be accrued for this study within 2 years. ...
RATIONALE: Drugs used in chemotherapy, such as 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG), work in different ways to stop the g
Looking for online definition of 1,4-benzoquinone in the Medical Dictionary? 1,4-benzoquinone explanation free. What is 1,4-benzoquinone? Meaning of 1,4-benzoquinone medical term. What does 1,4-benzoquinone mean?
PRIMARY OBJECTIVES:. I. To determine the maximum tolerated dose of geldanamycin analogue (AAG) in patients with advanced solid tumors.. II. To determine the toxic effects of this drug in this patient population. III. To determine the biochemical and molecular effects of this drug in normal and accessible tumor tissue in these patients.. IV. To determine the pharmacokinetics of this drug in these patients. V. To assess any antitumor activity of this drug in these patients.. OUTLINE: This is a dose-escalation study.. Patients receive geldanamycin analogue (AAG) IV over 1-6 hours once daily on days 1, 4, 15, and 18. Courses repeat every 4 weeks in the absence of disease progression or unacceptable toxicity. Cohorts of 3-6 patients receive escalating doses of AAG until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2 of 6 patients experience dose-limiting toxicity. Once the MTD is determined, an additional 10 patients are treated at the ...
Thymoquinone, a major ingredient of black seed oil (Nigella sativa), has been shown to exhibit anticancer capacity in various types of cancers. However, there are few studies concerning the correlation between thymoquinone and epithelial-to-mesenchymal transition (EMT) in prostate cancer. In the present study, we firstly found that thymoquinone showed antimetastatic capacity in prostate cancer DU145 and PC3 cells. Additionally, thymoquinone reversed EMT by increasing E-cadherin expression and decreasing vimentin and Slug expression in a concentration-dependent manner. Recent studies have shown that the transforming growth factor-β (TGF-β) signaling pathway may be associated with EMT. Intriguingly, the expression of TGF-β, Smad2 and Smad3 at the mRNA and protein levels was notably reduced upon thymoquinone treatment in prostate cancer DU145 and PC3 cells. Subsequently, we confirmed that thymoquinone repressed metastasis and EMT of prostate cancer through downregulation of the TGF-β/Smad2/3 ...
Self-dimerisation of the three isomeric semiquinone radicals is considered herein. Optimised geometries and thermochemical parameters, in terms of heat of formation, entropy, heat capacity and Gibbs free energy of formation are provided for all possible cross coupling products. It is found that self-dimerisation of the three semiquinone radicals is not as thermodynamically favoured as the self-dimerisation of the phenoxy radical. Accordingly, the three isomeric semiquinone radicals can be regarded as less active precursors for the formation of dioxin compounds than phenoxy radicals.. ...
TY - CHAP. T1 - Tissue distribution and intracerebral tumor penetration of 2,5-diaziridinyl-3,6-biscarboethoxyamino-1,4-benzoquinone (AZO, NSC 182986) in man. AU - Savaraj, Niramol. AU - Lu, K.. AU - Stewart, D.. PY - 1981/1/1. Y1 - 1981/1/1. UR - http://www.scopus.com/inward/record.url?scp=17544399898&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=17544399898&partnerID=8YFLogxK. M3 - Chapter. AN - SCOPUS:17544399898. VL - Vol. 22. BT - Proceedings of the American Association for Cancer Research. ER - ...
Thymoquinone is an active ingredient isolated from Nigella sativa and has been investigated for its anti-oxidant, anti-inflammatory and anticancer activities in both in vitro and in vivo models since its first extraction in 1960s. Its anti-oxidant/anti-inflammatory effect has been reported in various disease models, including encephalomyelitis, diabetes, asthma and carcinogenesis. Moreover, thymoquinone could act as a free radical and superoxide radical scavenger, as well as preserving the activity of various anti-oxidant enzymes such as catalase, glutathione peroxidase and glutathione-S-transferase. The anticancer effect(s) of thymoquinone are mediated through different modes of action, including anti-proliferation, apoptosis induction, cell cycle arrest, ROS generation and anti-metastasis/anti-angiogenesis. In addition, this quinone was found to exhibit anticancer activity through the modulation of multiple molecular targets, including p53, p73, PTEN, STAT3, PPAR-γ, activation of caspases ...
Results of the present study indicate that cotreatment with the Hsp90 antagonist 17-AAG and clinically relevant HDAC inhibitors results in a striking increase in mitochondrial injury, caspase activation, and apoptosis in Bcr-Abl+ human leukemia cells. These events are associated with Bcr-Abl down-regulation; multiple perturbations in Bcl-2 family member proteins, particularly induction of Bax conformational change; and disruption of diverse signaling/cell cycle regulatory pathways, including those related to STAT5, Raf/MEK/ERK, and Akt.. Translocation and integration of cytoplasmic Bax into the mitochondrial membrane represent critical steps in activation of the mitochondrial apoptotic pathway in multiple systems (Yamaguchi et al., 2003). Moreover, a conformational change in Bax, resulting in exposure of the NH2 and COOH termini, is required for release of proapoptotic mitochondrial proteins (Murphy et al., 2000). The present results demonstrate that 17-AAG induces a conformational change in Bax ...
I found nothing on any possible reaction between acetone and p-benzoquinone with SciFinder. If there would be a reaction under basic conditions, I would guess that 5-hydroxy-2-methylbenzofurane would be the expected product. I would guess the reason why this apparently does not happen is because benzoquinone is unlikely to be stable toward the strong bases required for the enolization of acetone (such as hydroxides which can react with quinones themselves ...
This phase I trial is studying the side effects and best dose of giving PDX101 together with 17-AAG in treating patients with metastatic or unresectable
The invention relates to a new type of highly polar, at least double-negatively charged redox-active benzoquinones, notably derived from Coenzyme Q0, Q1 and dimethoxy benzoquinones, its production and use. The production of these benzoquinones comprises the reaction of dimethoxy benzoquinones with highly alkaline aqueous solutions. The benzoquinones of the invention have various potential applications in pharmaceutical and cosmetic industry (namely as antioxidants, anti-ageing agents and the like), in organic synthesis, metal complexations, metal separations, potentiometric titrations, interfacial catalysis, and ion-transfer reactions across biological membranes.. ...
Herbimycin A, 1 mg. Herbimycin A, a benzoquinoid ansamycin antibiotic, irreversibly and selectively inhibits tyrosine kinases by reacting with thiol groups (1,2).
1. HT-29 M6 cells are a subpopulation of HT-29 cells that, contrarily to the parental cells, establish tight cell contacts and differentiate. Cell-to-cell contacts in HT-29 M6 cells are also regulated by protein kinase C; addition of the phorbol ester phorbol 12-myristate 13-acetate (PMA) decreases the homotypic contacts of these cells. We show here that HT-29 cells or HT-29 M6 cells treated with PMA contain lower levels of functional E-cadherin, determined by analysing the association of this protein with the cytoskeleton. No significant differences in the localization of α-, β-, or p120-catenins were detected under the three different conditions. 2. Dysfunction of E-cadherin can be reversed by incubation of HT-29 cells with the tyrosine kinase inhibitor herbimycin A. On the other hand an augmentation of c-src activity in HT-29 cells or HT-29 M6 cells treated with PMA was observed with respect to control HT-29 M6 cells. The phosphorylation status of catenins was also investigated; in HT-29 or ...
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sativa and several of its Lively compounds, such as thymoquinone and alpha-hederin. Acute and Continual toxicity reports have just lately verified the security of N. sativa oil and its most plentiful active ingredient, thymoquinone, especially when given orally. The present do the job is aimed toward summarizing the exceptionally worthwhile work accomplished by various investigators on the effects of N. sativa seed, its extracts and Lively principles versus most cancers. Those connected with the underlying system of action, derivatives of thymoquinone, nano thymoquinone and combos of thymoquinone Along with the at the moment employed cytotoxic medicines are of distinct curiosity. We hope this critique will stimulate intrigued scientists to conduct even more preclinical and medical experiments to evaluate the anticancer actions of N. sativa, its Energetic constituents as well as their derivatives ...
Buy N-Acetyl-4-benzoquinone Imine online from Pharmaceutical toxicology. Certified reference materials for highly accurate and reliable data analysis.
Four naturally occurring dimeric phenylethyl benzoquinones, parvistemins A-D, were isolated from the aerial parts of Stemona parviflora Wright. Their constitutions were established by spectroscopic methods. Due to restricted rotation about the central biaryl axis, the compounds are chiral, although racemic. Their two respective atropo-enantiomers were resolved by HPLC on a chiral phase and were stereochemically characterized online, in hyphenation with circular dichroism (CD) spectroscopy (LC-CD coupling), combined with quantum chemical CD calculations ...
TY - JOUR. T1 - Geldanamycin selectively targets the nascent form of ERBB3 for degradation. AU - Gerbin, Candice S.. AU - Landgraf, Ralf. PY - 2010/9. Y1 - 2010/9. N2 - Heat shock protein 90 (HSP90) targets a broad spectrum of client proteins with divergent modes of interaction and consequences. The homologous epidermal growth factor receptor (EGFR) and ERBB2 receptors as well as kinase-deficient mutants thereof differ in their requirement for HSP90 in the nascent versus mature state of the receptor. Specific features of the kinase domain have been implicated for the selective association of HSP90 with mature ERBB2. We evaluated the role of HSP90 for the homologous ERBB3 receptor. ERBB3 is naturally kinase deficient, a central mediator in cell survival and stress response and the primary dimerization partner for ERBB2 in signaling. Cellular studies indicate that, similar to EGFR, the geldanamycin (GA) sensitivity of ERBB3 and HSP90 binding resides in the nascent state and is dependent on the ...
Also, the expression of cleaved caspase-3 and Smac were being upregulated in SaOS-two cells just after treatment with thymoquinone. In combination with these in vitro effects, we also discovered that thymoquinone inhibits tumor angiogenesis and tumor development via suppressing NF-κB and its controlled molecules. Collectively, our final results demonstrate that thymoquinone successfully inhibits tumor growth and angiogenesis both in vitro As well as in vivo. In addition, inhibition of NF-κB and downstream effector molecules is often a attainable fundamental mechanism on the antitumor and anti-angiogenic action of thymoquinone in osteosarcoma ...
Introduction of Idebenone Just what is Idebenone? Those of you who have inquired into the Idebenone compound will see that the internet is awash with all manner
Idebenone is a member of the quinone family, and like hydroquinone, has been used in various skin care regimes. Know more about Idebenone.
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Rikova K (2013) CST Curation Set: 18855; Year: 2013; Biosample/Treatment: cell line, H3122/crizotinib, geldanamycin; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: acK ...
The anti-inflammatory nigella sativa component thymoquinone compromises the function of dendritic cells (DCs), key players in the regulation of innate and adaptive immunity. DC function is regulated by the Na(+)/H(+) exchanger (NHE), which is stimulated by lipopolysaccharides (LPS) and required for LPS-induced cell swelling, reactive oxygen species (ROS) production, TNF-? release and migration. Here we explored, whether thymoquinone influences NHE activity in DCs. To this end, bone marrow derived mouse DCs were treated with LPS in the absence and presence of thymoquinone (10 ?M). Cytosolic pH (pH(i border=0> was determined from 2,7-bis-(2-carboxyethyl)-5-(and-6)-carboxyfluorescein (BCECF) fluorescence, NHE activity from the Na(+)-dependent realkalinization following an ammonium pulse, cell volume from forward scatter in FACS analysis, ROS production from 2,7-dichlorodihydrofluorescein diacetate (DCFDA) fluorescence, TNF-? production utilizing ELISA and DC migration with transwell migration ...
3877 The geldanamycin derivative, 17-allyamino-17-demethoxygeldanamycin (17-AAG), is a selective HSP90 inhibitor that is now under clinical investigation. The biomarkers that have been used in 17-AAG clinical trials to date are HSP70, Raf-1 and CDK4. HSP70 was induced during 17-AAG treatment, whereas Raf-1 and CDK4 were repressed. All three biomarkers have to be analyzed by western blot of cellular samples, either from tumor biopsy or PBMC cells isolated from patient blood. This analytical method is time-consuming and laborious. We have identified two new biomarkers, IGFBP2 and HER-2 ECD (HER-2 extracellular domain), both of which can be readily detected in patient sera by ELISA. IGFBP-2 is an Insulin-like Growth Factor binding protein that modulates the activity and facilitates the transportation of IGF and is regulated via the PI3K/AKT pathway. Inhibition of HSP90 causes AKT degradation and thus should in turn attenuate secretion of IGF-BP2. HER-2 ECD is a shed form of HER-2 that circulates in ...
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Objectives: To determine the antioxidant effects of thymoquinone (one of the active components of the plant Nigella sativa) on ischemia-reperfusion in..
The binding of heat shock protein 90 (HSP90) to endothelial nitric oxide (NO) synthase (eNOS) can enhance eNOS activation. Studies have shown that the HSP90-specific inhibitor geldanamycin (GA) can cause attenuation of NO-mediated processes. Twenty subjects participated in one of two protocols. In each protocol, one forearm of each subject was instrumented with two intradermal microdialysis probes for drug delivery. Laser Doppler flowmeters were used to measure cutaneous blood flow. Skin sites were either treated with the endothelial agonist acetylcholine or locally heated to 42 degrees C, a maneuver that evokes NO-mediated dilation. Interventions were performed with and without GA. In the presence of GA, maximal cutaneous vascular conductance (CVC) to ACh was 20 +/- 3% lower than with ACh alone (P | 0.001). During local heating, maximal CVC in the presence of GA was 22 +/- 6% lower than during heating alone (P | 0.01). The results show that GA can attenuate NO-mediated dilation in human skin,
CD20 is a B cell-specific 35/37 kDa integral membrane protein which modulates proliferation and differentiation of normal resting B cells when stimulated by CD20 antibodies. An increase in c-myc mRNA levels occurs within hours after treatment of resting B cells with CD20 mAb; however earlier events in the CD20 signal transduction pathway have not been described. Here we demonstrate that anti-CD20 mediated induction of c-myc mRNA is inhibited by the tyrosine kinase inhibitor herbimycin A, that CD20 is associated with both tyrosine and serine kinase activity, and that tyrosine phosphorylation of multiple substrates is induced within minutes upon ligation of CD20 with mAb. Association of the tyrosine and serine kinases with CD20 was stable in lysis buffer containing 1% NP40 and 0.25% deoxycholate. Under the same conditions, antibodies against several other B cell surface molecules failed to co-precipitate tyrosine kinase activity, however, a serine kinase was precipitated by the anti-CD19 mAb, B43. ...
Embelin has been shown to have potential for• fertility regulation in male mammals. To further investigate this the effect of varying doses of embelin administered through different routes on plasma testosterone levels in sexually mature male white New Zealand rabbits was studied. An intramuscular injection of 5 mglkg body weight of embelin caused a 54% declined in testosterone levels from S.35±0.4 nmol (pre-treatment) to 3.S±0.15 nmollL (post-treatment); mean±SEM. When orally administered as a suspension of 10 mglkg body weight embelin caused a significant (p,O.OOI) lowering in the hormone levels from 12.2±0.70 nmollL (pre-treatment) to 4.S5±0.35 nmollL after treatment. But when administered orally as a 50 mg base tablet, a decline of 40% in testosterone levels was observed. Subcutaneous administration of 20 mglkg body weight of embelin caused a 12.4% decline in. the hormone levels from 26.6±1.30 nmollL (pre-treatment) to IS.9±1.30 nmol/L after treatment. The decline in the ...
A myriad of medicinal effects has been attributed to Thymoquinone (TQ), the major biological-active component of Nigella sativa. TQ has been shown to exhibit potent anti-tumor activities. The present work was undertaken to further explore TQs chemopreventive efficacy against 1, 2-dimethylhydrazine (DMH)-induced colon carcinogenesis in the rat model through a two-phase study (initiation and post-initiation) and to evaluate its potential impact on tumor progression and invasion in vivo. TQ treatment in the initiation phase significantly reduced tumor incidence, multiplicity and mean tumor volume. However, although mean tumor volume and multiplicity were decreased upon TQ treatment in the post-initiation phase, TQ did not reduce incidence significantly. Cellular proliferation, as assessed by expression of colonic PCNA, was shown to be inhibited in consequence to TQ treatment in both phases, with a more pronounced reduction in the initiation phase. In addition, our results demonstrated an appreciable
An Hsp90 inhibitor is a substance that inhibits that activity of the Hsp90 heat shock protein. Since Hsp90 stabilizes a variety of proteins required for survival of cancer cells, these substances may have therapeutic benefit in the treatment of various types of malignancies. Furthermore, a number of Hsp90 inhibitors are currently undergoing clinical trials for a variety of cancers. Hsp90 inhibitors include the natural products geldanamycin and radicicol as well as semisynthetic derivatives 17-N-Allylamino-17-demethoxygeldanamycin (17AAG). Among heat shock proteins the focus on HSP90 has increased due to its involvement in several cellular phenomenon and more importantly in disease progression. HSP90 keeps the death proteins in an apoptosis resistant state by direct association. Its wide range of functions results from the ability of HSP90 to chaperone several client proteins that play a central pathogenic role in human diseases including cancer, neurodegenerative diseases and viral infection. ...
Recent reports claimed that thymoquinone exhibited inhibitory results over the cell proliferation of various cancer cell strains. This research was done to investigate the antitumor and anti-angiogenic results of thymoquinone on osteosarcoma in vitro As well as in vivo. Our outcomes confirmed that thymoquinone induced a higher proportion of expansion inhibition and apoptosis within the human osteosarcoma mobile line SaOS-two in comparison with that of Regulate, and thymoquinone considerably blocked human umbilical vein endothelial mobile (HUVEC) tube development inside a dose-dependent way. To analyze the achievable mechanisms linked to these activities, we executed electrophoretic mobility shift assay (EMSA) and western blot Examination, and located that thymoquinone considerably downregulated NF-κB DNA-binding action, XIAP, survivin and VEGF in SaOS-two cells ...
Thymoquinone (TQ), the main constituents of the volatile oil from Nigella sativa seeds is reported to protect laboratory animals against chemical carcinogenesis and toxicity through mechanism(s) that is not fully understood. Among possible mechanism(s), protection could be mediated via induction of …
Differentiated primary cultures of airway epithelia. Cells were obtained from the University of Iowa Cells and Tissue Core. Epithelial cells were isolated from the trachea and bronchi by enzymatic digestion, seeded onto collagen-coated, semipermeable membranes (0.6 cm2 Millicell-PCF; MilliporeSigma), and grown at the air-liquid interface as previously described (142). Culture medium, a 1:1 mixture of DMEM/F12, was supplemented with 2% Ultroser G (PALL Corp.). Differentiated epithelial cells were used at least 14 days after seeding. All experiments were performed on passage-0 primary cells obtained from fresh tissue. Media were changed every 2 days. At every media change, 20 μl basolateral media were uniformly added to the apical surface to allow basolateral and apical exposure to treatment conditions. Treatment conditions included IL-13 (20 ng/ml), IL-17 (20 ng/ml), geldanamycin (25 μM), and HDAC6 inhibitor ISOX (10 μM). Treatment durations are indicated in the results section corresponding ...
Anti-inflammatory activities of thymoquinone (TQ) have been demonstrated in in vitro and in vivo studies. However, the precise mechanism(s) of TQ in these anti-inflammatory activities is not well unde
Tanespimycin TIME Registration Program to Begin Third Quarter 2007 Kosan Biosciences Incorporated presented data from a dose-escalating Phase 1b clinical trial
sorgoleone: Sorgoleone refers to a group of benzoquinones from Sorghum bicolor having 2-hydroxy and 5-methoxy substitutions and either a 15- or 17-carbon chain with one, two, or three double bonds at position 3; The name sorgoleone was first given to 5-methoxy-3-(8Z,11Z)-pentadeca-81114-trienylbenzene-1,2,4-triol but this is unstable and is easily oxidized to the quinone, sorgoleone-358, which is the major constituent of the root exudate; binds at PLASTOQUINONE site of PSII
Heat shock protein 90 (Hsp90) is a molecular chaperone that is responsible for activating many signaling proteins and is a promising target in tumor biology. We have identified small-molecule benzisoxazole derivatives as Hsp90 inhibitors. Crystallographic studies show that these compounds bind in the ATP binding pocket interacting with the Asp93. Structure based optimization led to the identification of potent analogues, such as 13, with good biochemical profiles. Discovery of benzisoxazoles as potent inhibitors of chaperone heat shock protein 90.,Gopalsamy A, Shi M, Golas J, Vogan E, Jacob J, Johnson M, Lee F, Nilakantan R, Petersen R, Svenson K, Chopra R, Tam MS, Wen Y, Ellingboe J, Arndt K, Boschelli F J Med Chem. 2008 Feb 14;51(3):373-5. Epub 2008 Jan 16. PMID:18197612[3] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine ...
Figure 2. Geldanamycin and bortezomib show enhanced antiproliferative activity in combination and convert cytostasis to a cytocidal outcome. MCF-7 cells were seeded into 96-well plates; 24 h later, they were treated with geldanamycin and bortezomib (six wells/concentration) as indicated in A-C. Antitumor activity was assessed 3 or 4 days later by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide spectrophotometric assay. A, surviving fractions of cells are shown after 3 days exposure to a range of concentrations of geldanamycin alone (open circles) or with 2 nm (shaded squares), 5 nm (shaded circles), or 10 nm (triangles) bortezomib. B, antiproliferative affect of bortezomib alone after 3 days of exposure. C, cells were exposed to a range of geldanamycin concentrations without (open circles) and with 10 nm (triangles) bortezomib for 4 days. Note that geldanamycin alone was cytostatic, and concentrations above 100 nm did not yield any additional antiproliferative activity. Exposing ...
The serine/threonine kinase Polo-like kinase 1 (Plk1) is overexpressed in many types of human cancers, and has been implicated as an adverse prognostic marker for cancer patients. Plk1 localizes to its intracellular anchoring sites via its polo-box domain (PBD). Here we show that Plk1 can be inhibited by small molecules which interfere with its intracellular localization by inhibiting the function of the PBD. We report the natural product thymoquinone and, especially, the synthetic thymoquinone derivative Poloxin as inhibitors of the Plk1 PBD. Both compounds inhibit the function of the Plk1 PBD in vitro, and cause Plk1 mislocalization, chromosome congression defects, mitotic arrest, and apoptosis in HeLa cells. Our data validate the Plk1 PBD as an anticancer target and provide a rationale for developing thymoquinone derivatives as anticancer drugs.
nigellone: inhibits histamine release from mast cells; a carbonyl polymer of thymoquinone, isolated from Nigella sativa L. seeds; less toxic than thymoquinone
Retaspimycin hydrochloride (IPI-504), an Hsp90 (heat shock protein 90) inhibitor, has shown activity in multiple preclinical cancer models, such as lung, breast and ovarian cancers. However, its biolo
Idebenone adalah sebatian komposit yang menyerupai Uqinone dalam badan manusia . Ia adalah dalam kelompok yang sama dengan enzyme Q10 . tetapi , kebanyakan enzyme ini bersifat MUDAH TERURAI menyebabkan pegambilannya adalah tidak berkesan dan tidak dapat diserap oleh badan sepenuhnya. Idebenone juga banyak digunapakai oleh negara barat dalam peghasilan kosmetik dan pil . Ini kerana , idebenone bersifat FREE RADICAL , tidak berbahaya serta anti penuaan . Idebenone berupaya melindungi kulit daripada UVA dan UVB . Idebenone juga mempercepat penghasilan collagen tanpa perlu anda mengambilnya . Hasilnya , kulit kurang kedutan , tegang dan licin . Bukan itu sahaja , idebenone merancakkan penghasilan hormone menyebabkan payudara menjadi lebih tegang , besar dan gebu ...
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Copyright 2011 Elsevier. All rights reserved. NOTICE: this is the authors version of a work that was accepted for publication in Synthetic Metals. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Synthetic Metals, 161(21-22), November 2011, DOI 10.1016/j.synthmet.2011.08.045 ...
Extract flooded mixture with 3 portions of DCM (1 x 500mL, 1 x 250mL, 1 x 100mL) in a large separatory funnel. The desired raw product, MDP-2-P ( ketone ), migrates into the DCM as an oil. Separate the DCM/ketone layers and combine them. (Note: when you first hit it with the DCM you will probably observe a bit of scum which will float on top of the water layer, which will work its way down during these three extractions to appear as a blob of spongy semi-solid interface. It s actually very mobile and easy to work around; simply avoid allowing it into your DCM separations. The same thing will happen in your washes in Steps 10, 11 and 12 below, but by then you will be quite the pro at working with it.) ...
Chemical Entities of Biological Interest (ChEBI) is a freely available dictionary of molecular entities focused on small chemical compounds.
Hsp90 (heat shock protein 90) is usually a key component of your molecular chaperone sophisticated which props up conformational adulthood plus stabilization of countless oncoproteins, like signaling kinases, transcription things, and also progress component receptors (A person,-3). Hsp90 lovers the actual binding as well as hydrolysis with ATP to your correct collapsable connected with client healthy proteins (4, A few). A ansamycin training with inhibitors for example the healthy product geldanamycin, its offshoot 17-allyamino-geldanamycin (17-AAG)2 plus IPI-504, the really disolveable hydroquinone sea salt regarding 17-AAG, well lessen ATP holding as well as in so doing a chaperoning pastime associated with Hsp90 (Several,-7). SNX-2112 binds Hsp90 with a 50-fold higher appreciation as compared with 17-AAG (8, In search of), offers antitumor pastime in a variety of pet growth types (12,-14), and it has also been assessed in a number of clinical studies. While these types of Hsp90 inhibitors ...
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Cordiachromes A-F are terpenoid benzoquinones isolated from the heartwood of . Cordiachrome C (3; R = H) has a benzogeijerene and A (1; R = H) and B (2; R = H) have a benzocogeijerene skeleton. Cordiachromes D-F are methoxy-derivatives of A-C, respectively. All six are optically inactive. Biogenetically they appear
All experimentally characterized proteins in this family are 1,4-benzoquinone reductases. These are intracellular enzymes involved in the biodegradation of aromatic compounds and in the protection of fungal cells from reactive quinone compounds ...
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Pokud nenaleznete technický dotazník pro Vámi požadovaný druh, použijte TD ze stránek CPVO nebo tento technický dotazník. If you dont find the TQ for your requiered species, use the TQ from the CPVO website or this General Technical Questionaire.. ...
1,2-Benzoquinone 1,4-Benzoquinone 1,4-Naphthoquinone 9,10-Anthraquinone The term quinone is also used more generally for a ... Benzoquinone is used in organic chemistry as an oxidizing agent. Strongly oxidizing quinones include chloranil and 2,3-dichloro ... Dahlin, D. C.; Miwa, G. T.; Lu, A. Y.; Nelson, S. D. (1984). "N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated ... Benzoquinone compounds are a metabolite of paracetamol. Many natural and artificial coloring substances (dyes and pigments) are ...
The reaction proceeds only in the presence of sodium acetate; Moiseev used benzoquinone to regenerate the Pd(II) catalyst. CH2= ...
4-benzoquinone. If methylamine or diethylamine are present in the solution 2-methyl-1,4-benzoquinone will readily react. ... Monoepoxides and diepoxides of 2-methyl-1,4-benzoquinone are formed. In an experiment where young brown bullhead were exposed ...
ISBN 978-0-8018-6251-9. Weldon, P.J.; Aldrich, J.R.; Klun, J.A.; Oliver, J.E.; Debboun, M. (2003). "Benzoquinones from ... The anointment must also involve risks, since benzoquinones are toxic and carcinogenic, however, it is likely that for ... Chemical analysis revealed these millipedes secrete two benzoquinones, compounds known to be potently repellent to insects and ...
Also known as tetrachloro-1,4-benzoquinone, it is a yellow solid. Like the parent benzoquinone, chloranil is a planar molecule ... Chloranilic acid 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) Chloranil at Sigma-Aldrich J.-M. Lü, S. V. Rosokha, I. S. ...
It forms volatile yellow triclinic crystals and has a sharp odor similar to benzoquinone. It is almost insoluble in cold water ... Hydroxynaphthoquinone 1,4-Benzoquinone Plumbagin Quinone Hooker reaction Merck Index, 11th Edition, 6315. Gaultier, J.; Hauw, C ...
... specifically derivatives of benzoquinones, were discovered; these showed antifungal, antibacterial, and cytotoxic activities. ... new antifungal and antibacterial benzoquinones from the coprophilous fungus Podospora anserina. Slot, Jason C.; Rokas, Antonis ...
para-Benzoquinone in DMSO. A solution of para-benzoquinone in DMSO reacts with inorganic cyanide to form a cyanophenol, which ... "Fluorometric determination of cyanide in biological fluids with p-benzoquinone*1". Toxicology and Applied Pharmacology. 55 (1 ...
4-benzoquinone with aminoguanidine and thiosemicarbazide. Obtaining a pharmaceutical grade material is difficult due to high ...
Warren, L. F. (1977). "Synthesis of [M'-N4] and [M'-N6] Complexes Based on o-Benzoquinone Diimine with Cobalt, Iron, and ...
1,4-benzoquinone Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa ... The oxidation of aniline by manganese dioxide followed by reduction of the resulting 1,4-benzoquinone. The process is conducted ... When colorless hydroquinone and benzoquinone, a bright yellow solid, are co-crystallized in a 1:1 ratio, a dark-green ... Hydroquinone undergoes oxidation under mild conditions to give benzoquinone. This process can be reversed. Some naturally ...
Simple phenols, Benzoquinones Catechol, Hydroquinone, 2,6-Dimethoxybenzoquinone 7 C6-C1 1 Phenolic acids, Phenolic aldehydes ...
Such species remain reactive and will react further, giving products such as 1,4-benzoquinone, phenylenediamine-dimers and ...
Among the many irritant and toxic chemicals found in these secretions are alkaloids, benzoquinones, phenols, terpenoids, and ... is elicited by benzoquinones from millipedes". Naturwissenschaften. 93 (1): 14-16. Bibcode:2006NW.....93...14W. doi:10.1007/ ... "Benzoquinones from millipedes deter mosquitoes and elicit self-anointing in capuchin monkeys (Cebus spp.)". ...
Among the many irritant and toxic chemicals found in these secretions are alkaloids, benzoquinones, phenols, terpenoids, and ... Weldon, Paul J.; Aldich, Jeffrey R.; Klun, Jerome A.; Oliver, James E.; Debboun, Mustapha (2003). "Benzoquinones from ... is elicited by benzoquinones from millipedes". Naturwissenschaften. 93 (1): 14-16. doi:10.1007/s00114-005-0064-z.. ...
4-Benzoquinone". Organic Syntheses. 76: 189. doi:10.15227/orgsyn.076.0189. Ian Storer, R.; Aciro, Caroline; Jones, Lyn H. (2011 ...
... benzoquinone is formed (see reaction below). Hydrogens removed from catechol combine with oxygen to form water. The substrate ...
... high dose acetaminophen can lead to the formation of the reactive metabolite N-acetyl-p-benzoquinone imine. Also, covalent ...
... ethanol Aziridyl benzoquinone Azobenzene 11H-Benz[bc]aceanthrylene Benz[l]aceanthrylene Benz[a]acridine Benz[c]acridine Benzo[g ... para-benzoquinone (Triaziquone) Tris(1-aziridinyl)phosphine oxide 2,4,6-Tris(1-aziridinyl)-s-triazine Tris(2-chloroethyl) ... pyrene p-Benzoquinone dioxime Benzoyl peroxide Benzyl acetate Bis(1-aziridinyl)morpholinophosphine sulfide Bis(2-chloroethyl) ...
6 or tetrahydroxy-p-benzoquinone C6(OH)4O2 and characterized by R. Nietzki and others in 1885, although the product was for a ...
6-dicyano-p-benzoquinone (DDQ) Conditions for deprotection of benzyl group are applicable for cleavage of the PMB protecting ...
The molecular formula C6H4O2 (molar mass: 108.09 g/mol) may refer to: 1,2-Benzoquinone, also called ortho-benzoquinone 1,4- ... Benzoquinone, also called para-quinone This set index page lists chemical structure articles associated with the same molecular ...
A substance that it secretes, 2,3-dimethoxy-geranyl- 1,4-benzoquinone (consisting of a quinonoid ring with a 10 or 11 carbon- ...
For example: p-Benzoquinone can be reduced to hydroquinone at the cathode: + 2 e− + 2 H+ → In the last example, H+ ions ( ...
4-benzoquinone. The oxidation of 2,4,6-tri-tert-butylphenol in the alkaline to the intensely blue-colored phenoxy radical can ...
4-benzoquinone), and similar in biological activity to the well-known anticoagulant heparin. Atromentin also possesses ...
Oxidation of hydroquinone gives 1,4-benzoquinone: C6H4(CHMe2)2 + 2.5 O2 → C6H4O2 + 2 OCMe2 + H2O Resorcinol is analogously ...
http://www.erowid.org/archive/rhodium/chemistry/benzoquinone.html. *↑ "Process for the preparation of p-benzoquinone" US patent ...
... , also called ortho-benzoquinone, is an organic compound with formula C6H4O2. It is one of the two isomers of ... 1,2-Benzoquinone is produced on oxidation of catechol exposed to air in aqueous solution or by ortho oxidation of a phenol. It ... ISBN 978-0-85404-182-4. Liao, Chun-Chen; Peddinti, Rama Krishna (2002). "Masked o-Benzoquinones in Organic Synthesis". Accounts ... MacDonald, Alistair L.; Trotter, James (1973). "Crystal and molecular structure of o-benzoquinone". Journal of the Chemical ...
The homogentisic acid is converted to the related substance benzoquinone acetic acid (BQA) which forms polymers that resemble ...
Get product specifications and salient feature of P-Benzoquinone along with company address and contact details. ... Buy low price P-Benzoquinone online from SHILPA INTERNATIONAL SPECIALTIES based in BELAPUR-CBD-BELAPUR, Navi Mumbai. ... We manufacture, export, trade and supply p-Benzoquinone in Navi Mumbai, Maharashtra, India. Our range of p-Benzoquinone reacts ... p-Benzoquinone can act as a staining agent for proteins and polyamides. It can also used as in-process polymerization inhibitor ...
Benzoquinone ansamycin (BQA) Hsp90 inhibitors such as 17-DMAG and 17-AAG have off-target toxicities in clinical trials ... Abstract 1788: 19-Substituted benzoquinone ansamycins. Hsp90 inhibitors with decreased off-target toxicity. Chuan-Hsin Chang, ... 19-Substituted benzoquinone ansamycins. Hsp90 inhibitors with decreased off-target toxicity. [abstract]. In: Proceedings of the ... Abstract 1788: 19-Substituted benzoquinone ansamycins. Hsp90 inhibitors with decreased off-target toxicity ...
4-BENZOQUINONE (D4, 98%). We are specialized in manufacturing Stabel Isotope Labeled Analytical Standard products. ... Home > Products > Stable Isotope Labeled Analytical Standard > Amino Acids > 1,4-BENZOQUINONE (D4, 98%) ...
The hydrolysis reaction was shown to be first order both with respect to the 1,2-benzoquinone and protons. At pH 6 and above, 4 ... At low pH ( , 3), the cyclic voltammogram of the benzoquinone changed rapidly to a second pair of peaks at lower potentials. ... These were shown to be due to 2-hydroxy-1,4-benzoquinone, formed by hydrolysis of the original compound. The other hydrolysis ... Using cyclic voltammetry, the electrochemistry of aqueous solutions of 4-methoxy-1,2-benzoquinone was investigated over the pH ...
4-Benzoquinone(106-51-4) Density MSDS Formula Use,If You also need to 1,4-Benzoquinone(106-51-4) Other information,welcome to ... 2-Methyl-5-isopropyl-1,4-benzoquinone,5-Isopropyl-2-methyl-p-benzoquinone,2-Methyl-5-isopropyl-p-benzoquinone ... 1,4-Benzoquinone Basic information. Product Name:. 1,4-Benzoquinone. CAS:. 106-51-4. MF:. C6H4O2. MW:. 108.09. EINECS:. 203-405 ... 1,4-Benzoquinone Usage And Synthesis. Description. Quinone (p-benzoquinone) exists as a large yellow, monoclinic prism with an ...
Kim, Y. B., Kim, I. T., Song, M. J., & Shin, M. W. (2016). Poly-vinylidene-fluoride/p-benzoquinone gel polymer electrolyte with ... Kim, YB, Kim, IT, Song, MJ & Shin, MW 2016, Poly-vinylidene-fluoride/p-benzoquinone gel polymer electrolyte with good ... In this study, the poly-vinylidene fluoride (PVDF)/p-benzoquinone (pBQ) gel polymer electrolyte (GPE) is synthesized well with ... T1 - Poly-vinylidene-fluoride/p-benzoquinone gel polymer electrolyte with good performance by redox mediator effect for Li-Air ...
P-Benzoquinone CAS 106-51-4 Benzoquinone p-Benzoquinone P-quinone PBQ Quinone from China manufacturer on Hisupplier.com. ... Product Details of P-Benzoquinone CAS 106-51-4 Benzoquinone p-Benzoquinone P-quinone PBQ Quinone, ... P-Benzoquinone CAS 106-51-4 Benzoquinone p-Benzoquinone P-quinone PBQ Quinone Payment Terms:. T/T,L/C,WU ... You are here: home , Other Chemical Products , P-Benzoquinone CAS 106-51-4 Benzoquinone p-Benzoquinone P-quinone PBQ Quinone ...
4-benzoquinone, 98+% 10g Alfa Aesar™ 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone, 98+% Dichlorotol to... ... 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone is used as a reagent for oxidative couplings and cyclization reactions and ...
Geldanamycin (GA) is a benzoquinone ansamycin antibiotic that disrupts Hsp90-protein interactions. Because EF-2 kinase is ... Geldanamycin (GA) is a benzoquinone ansamycin antibiotic that disrupts Hsp90-protein interactions. Because EF-2 kinase is ... Geldanamycin (GA) is a benzoquinone ansamycin antibiotic that disrupts Hsp90-protein interactions. Because EF-2 kinase is ... Geldanamycin (GA) is a benzoquinone ansamycin antibiotic that disrupts Hsp90-protein interactions. Because EF-2 kinase is ...
The main benzoquinone in the sub-family Myrsinodae is embelin while for the Maesodae it is maesaquinone together with its 5- ... The main benzoquinone in the sub-family Myrsinodae is embelin while for the Maesodae it is maesaquinone together with its 5- ... The main benzoquinone in the sub-family Myrsinodae is embelin while for the Maesodae it is maesaquinone together with its 5- ... Many other benzoquinones of medium and minor concentration were also isolated and characterised. Some plants belonging to the ...
1,2-Benzoquinone, also called ortho-benzoquinone, is an organic compound with formula C6H4O2. It is one of the two isomers of ... 1,2-Benzoquinone is produced on oxidation of catechol exposed to air in aqueous solution or by ortho oxidation of a phenol. It ... ISBN 978-0-85404-182-4. Liao, Chun-Chen; Peddinti, Rama Krishna (2002). "Masked o-Benzoquinones in Organic Synthesis". Accounts ... MacDonald, Alistair L.; Trotter, James (1973). "Crystal and molecular structure of o-benzoquinone". Journal of the Chemical ...
... has role mouse metabolite (CHEBI:75771) 1,4-benzoquinone (CHEBI:16509) is a 1,4-benzoquinones ( ... 1,4-benzoquinone imine (CHEBI:50192) has functional parent 1,4-benzoquinone (CHEBI:16509). 2-prenyl-1,4-benzoquinone (CHEBI: ... 1,4-benzoquinone (CHEBI:16509) has role cofactor (CHEBI:23357) 1,4-benzoquinone (CHEBI:16509) has role human xenobiotic ... 35796) has functional parent 1,4-benzoquinone (CHEBI:16509). quinhydrone (CHEBI:26491) has part 1,4-benzoquinone (CHEBI:16509) ...
Other names: 2,5-Cyclohexadiene-1,4-dione; p-Quinone; Chinone; Quinone; 1,4-Benzoquinone; 1,4-Cyclohexadienedione; Benzoquinone ...
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
Most quinones, with coenzyme Q10 as their best known representative, are seen as very efficient radical scavengers and antioxidants, commonly acting in a way to protect the living cells from oxidative damage. Although its antioxidative effect is undisputable, Q10 has one big disadvantage: due to the long, hydrophobic side-chain it is only slightly water-soluble. By a new easy reaction out of the natural substances coenzyme Q1 to Q10 new compounds are formed. The ubichinons are transformed into new substances. They show high solubility due to their polrity higher anti-oxidative effect than the natural substances ...
Tetrachloro-p-benzoquinone. ↓Other names: Regulatory process names [2] Trade names [3] Other names [1] IUPAC names [13] ...
Synonyms para-Benzoquinone Dioxime. * Actor Q *1,4-Benzoquinone dioxine * Dibenzo PQD * G-M-F * PQD * QDO * para-Quinone ... para-BENZOQUINONE DIOXIME. VOL.: 29 (1982) (p. 185) CAS No.: 105-11-3. Chem. Abstr. Name: 2,5-Cyclohexadiene-1,4-dione, dioxime ... para-Benzoquinone dioxime was tested for carcinogenicity at two dose levels in mice and rats by oral administration. No ... There is limited evidence that para-benzoquinone dioxime is carcinogenic to rats.. No case report or epidemiological study was ...
In a 2L flask fitted with a reflux condenser and addition funnel place 400ml MeOH, 50ml dH2O, 150g p-Benzoquinone and 2g PdCl2 ... If you let the PdCl2 stir alone for a while, when you then add the water and benzoquinone, let them stir for an hour as well ... Filter out the solids present in the mixture, which are hydroquinone (the degradation product of the benzoquinone) and PdCl2. ... Benzoquinone Wacker Oxidation of Safrole in Methanol. by Methyl Man. HTML by Rhodium ...
1,4-Benzoquinone, commonly known as para-quinone, is a chemical compound with the formula C6H4O2. In a pure state, it forms ... Benzoquinone vapours are very irritating to the eyes and to the respiratory system. Handle in a well ventilated area, ideally ... 1,4-Benzoquinone is sensitive toward both strong mineral acids and alkali, which cause condensation and decomposition of the ... An acidic potassium iodide solution reduces a solution of benzoquinone to hydroquinone, which can be reoxidized back to the ...
N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen. D C Dahlin, G T Miwa, A Y Lu, ... N-acetyl-p-benzoquinone imine (NAPQI) has been proposed as the toxic metabolite of acetaminophen for the past 10 years, ... N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen ... N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen ...
2-isopropyl-5-methyl-p-benzoquinone. Regulatory process names 1 IUPAC names 2 Other identifiers 1 ...
To elucidate the impact of benzoquinone (BQ) on lipid homeostasis and cytotoxicity in Saccharomyces cerevisiae. Methods: The ... Benzoquinone alters the lipid homeostasis in Saccharomyces cerevisiae A. Raj and V. Nachiappan, Toxicol. Res., 2019, Advance ... Objective: To elucidate the impact of benzoquinone (BQ) on lipid homeostasis and cytotoxicity in Saccharomyces cerevisiae. ...
... MoustafaM. ... 5-dihydroxy-P-benzoquinone and amines," Spectroscopy, vol. 15, no. 1, pp. 33-44, 2001. https://doi.org/10.1155/2001/721903. ...
"Alkaline Benzoquinone Aqueous Flow Battery for Large-Scale Storage of Electrical Energy". Germany. doi:10.1002/aenm.201702056. ... title = {Alkaline Benzoquinone Aqueous Flow Battery for Large-Scale Storage of Electrical Energy},. author = {Yang, Zhengjin ... Title: Alkaline Benzoquinone Aqueous Flow Battery for Large-Scale Storage of Electrical Energy. ... Publishers Accepted Manuscript: Alkaline Benzoquinone Aqueous Flow Battery for Large-Scale Storage of Electrical Energy ...
... Juan ... Juan Zhang, Meng Cao, Wenwen Yang, et al., "Inhibition of Glucose-6-Phosphate Dehydrogenase Could Enhance 1,4-Benzoquinone- ...
3,5-Di-tert-butyl-1,2-benzoquinone. e-EROS Encyclopedia of Reagents for Organic Synthesis. . ...
A related benzoquinone ansamycin that failed to revert transformed cells did not inhibit the formation of this complex. These ... 19-Substituted Benzoquinone Ansamycin Heat Shock Protein-90 Inhibitors: Biological Activity and Decreased Off-Target Toxicity ... Benzoquinone ansamycin 17AAG binds to mitochondrial voltage-dependent anion channel and inhibits cell invasion ... Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for ...
E)-2-[2-(4-Methyl-[2,2]bipyridinyl-4-yl)-vinyl]-[1,4]benzoquinone. Harald Zieg and Burkhard Koenig * ... Zieg, H.; Koenig, B. (E)-2-[2-(4-Methyl-[2,2]bipyridinyl-4-yl)-vinyl]-[1,4]benzoquinone. Molbank 2002, 2002, M276. ... Zieg H, Koenig B. (E)-2-[2-(4-Methyl-[2,2]bipyridinyl-4-yl)-vinyl]-[1,4]benzoquinone. Molbank. 2002; 2002(1):M276. ... E)-2-[2-(4-Methyl-[2,2]bipyridinyl-4-yl)-vinyl]-[1,4]benzoquinone." Molbank 2002, no. 1: M276. ...
The report generally describes para-benzoquinone(pbq), examines its uses, production methods, patents. Para-Benzoquinone(PBQ) ... Para-benzoquinone(pbq) prices in other regions. 7. PARA-BENZOQUINONE(PBQ) END-USE SECTOR 7.1. Para-benzoquinone(pbq) market by ... Para-benzoquinone(pbq) market forecast. 6. PARA-BENZOQUINONE(PBQ) MARKET PRICES. 6.1. Para-benzoquinone(pbq) prices in Europe. ... 3. PARA-BENZOQUINONE(PBQ) MANUFACTURING METHODS. 4. PARA-BENZOQUINONE(PBQ) PATENTS. Abstract. Description. Summary of the ...
2-hydroxy-3-methyl-1,4-benzoquinone. Submitted by Michael on Fri, 06/21/2013 - 12:06. ...
The combination of DDQ and NaNO2 showed high efficiency and high selectivity, compared with other benzoquinones and ... 6-dicyano-benzoquinone(DDQ) and NaNO2 with dioxygen is reported. ... 6-dicyano-benzoquinone(DDQ) and NaNO2 with dioxygen is reported ... The combination of DDQ and NaNO2 showed high efficiency and high selectivity, compared with other benzoquinones and ... Organocatalytic Oxidative Dehydrogenation of Dihydroarenes by Dioxygen Using 2,3-Dichloro-5,6-dicyano-benzoquinone (DDQ) and ...
X-irradiation of an Ar matrix doped with {\it p}-benzoquinone (PBQ) at 10 K leads to formation of the PBQ radical cation (PBQ ... MANIFESTATION OF NONADIABATIC EFFECTS IN THE IR SPECTRUM OF PARA-BENZOQUINONE RADICAL CATION. ...
0/Alkenes; 0/Allyl Compounds; 0/Benzoquinones; 0/Carboxylic Acids; 106-51-4/benzoquinone; 7440-05-3/Palladium ... Benzoquinones / chemistry*. Carboxylic Acids / chemistry*. Catalysis. Combinatorial Chemistry Techniques. Molecular Structure. ...
Attempted benzoquinone synthesis by tandem sulfuric acid hydrolysis and MnO2 oxidation. Ive just attempted to make ... Its also possible that there was some sort of exothermic reaction between benzoquinone and an impurity, or the ester itself?. ... Its possible it was caused by crystals of benzoquinone forming between the thermometer-well and distillation head, which ... 2. Use crude aminophenol in oxidation to benzoquinone using respective stoichiometric amount of oxidant ...
4-benzoquinone explanation free. What is 1,4-benzoquinone? Meaning of 1,4-benzoquinone medical term. What does 1,4-benzoquinone ... 4-benzoquinone, and 2-methoxy-3-methyl-l,4-benzoquinone (Fig.. Has vertebrate chemesthesis been a selective agent in the ... 1,4-benzoquinone. Also found in: Wikipedia. 1,4-ben·zo·qui·none. (benzō-kwinōn), 1. An essential part of coenzyme Q and ... 1,4-Benzoquinone decreased the quantum yield of HPD photobleaching at all concentrations studied (from 0.001 up to 0.25 mM) ( ...
benzoquinone ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs. ...
Benzoquinone ansamycin heat shock protein 90 inhibitors modulate multiple functions required for tumor angiogenesis. Sharon ... The benzoquinone ansamycin Hsp90 inhibitors geldanamycin and/or its derivatives 17-allylamino-17-demethoxygeldanamycin (17-AAG ... Benzoquinone ansamycin heat shock protein 90 inhibitors modulate multiple functions required for tumor angiogenesis ... We aimed to explore the potential of benzoquinone ansamycin Hsp90 inhibitors to modulate induction of, and response to, ...
5-di-tert-butyl-p-benzoquinone, examines its uses, production methods, patents. 2,5-Di-tert-butyl-p-benzoquinone market ... 2,5-di-tert-butyl-p-benzoquinone prices in other regions. 7. 2,5-DI-TERT-BUTYL-P-BENZOQUINONE END-USE SECTOR 7.1. 2,5-di-tert- ... 2,5-di-tert-butyl-p-benzoquinone market forecast. 6. 2,5-DI-TERT-BUTYL-P-BENZOQUINONE MARKET PRICES. 6.1. 2,5-di-tert-butyl-p- ... benzoquinone prices in Europe. 6.2. 2,5-di-tert-butyl-p-benzoquinone prices in Asia 6.3. 2,5-di-tert-butyl-p-benzoquinone ...
  • ChEBI: The simplest member of the class of 1,4-benzoquinones, obtained by the formal oxidation of hydroquinone to the corresponding diketone. (chemicalbook.com)
  • Preparation of Quinone (p-Benzoquinone) from Hydroquinone. (chemicalbook.com)
  • Geldanamycin (GA) is a benzoquinone ansamycin antibiotic that disrupts Hsp90-protein interactions. (elsevier.com)
  • 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone is used as a reagent for oxidative couplings and cyclization reactions and dehydrogenation of alcohols, phenols and steroid ketones. (fishersci.co.uk)
  • Our range of p-Benzoquinone reacts as a cross linking agent with synthetic polyamides. (tradeindia.com)
  • 1,4-Benzoquinone or p-benzoquinone is the basic structure of quinonoid compounds.They are widely distributed in the natural world, being found in bacteria, plants and arthropods and hence quinones are ubiquitous to living systems. (chemicalbook.com)
  • Quinone (p-benzoquinone) exists as a large yellow, monoclinic prism with an irritating odour resembling that of chlorine. (chemicalbook.com)
  • p-Benzoquinone can act as a staining agent for proteins and polyamides. (tradeindia.com)
  • It is one of the two isomers of quinone, the other being 1,4-benzoquinone. (wikipedia.org)
  • 1,4-Benzoquinone , commonly known as para-quinone , is a chemical compound with the formula C 6 H 4 O 2 . (sciencemadness.org)
  • An acidic potassium iodide solution reduces a solution of benzoquinone to hydroquinone , which can be reoxidized back to the quinone with a solution of silver nitrate . (sciencemadness.org)
  • The archetypical member of the class is 1,4-benzoquinone or cyclohexadienedione, often called simply "quinone" (thus the name of the class). (wikipedia.org)
  • 1,2-Benzoquinone 1,4-Benzoquinone 1,4-Naphthoquinone 9,10-Anthraquinone The term quinone is also used more generally for a large class of compounds formally derived from aromatic quinones through replacement of some hydrogen atoms by other atoms or radicals. (wikipedia.org)
  • Another quinone-containing drug is Mecarbinate (dimecarbine), made by the reaction of ethyl N-methyl-β-aminocrotonate with para-benzoquinone. (wikipedia.org)
  • Quinone (p-benzoquinone) exists as a large yellow, monoclinic prism with an irritating odour resembling that of chlorine. (chemicalbook.com)
  • Quinone (p-benzoquinone) was first produced commercially in 1919 and has since been manufactured in several European countries. (chemicalbook.com)
  • Preparation of Quinone (p-Benzoquinone) from Hydroquinone. (chemicalbook.com)
  • Coenzyme Q10, also known as ubiquinone-10, is a 1,4-benzoquinone, where Q refers to the quinone chemical group, and 10 refers to the number of isoprenyl chemical subunits in its tail. (rcsb.org)
  • N-acetyl-p-benzoquinone imine (NAPQI) has been proposed as the toxic metabolite of acetaminophen for the past 10 years, although it has never been detected as an enzymatic oxidation product of acetaminophen. (pnas.org)
  • Furthermore, as a measurement of potential hepatotoxicity, the molar dose fraction of acetaminophen converted to N-acetyl-p-benzoquinone imine (NAPQI) was estimated. (eur.nl)
  • The simplest member of the class of 1,4-benzoquinones, obtained by the formal oxidation of hydroquinone to the corresponding diketone. (ebi.ac.uk)
  • Filter out the solids present in the mixture, which are hydroquinone (the degradation product of the benzoquinone) and PdCl 2 . (erowid.org)
  • Benzoquinone can be prepared by oxidation of hydroquinone . (sciencemadness.org)
  • Among those peroxidases, myeloperoxidase is found with particularly high concentrations, which activates hydroquinone to 1,4-benzoquinone (1,4-BQ), a more reactive species of benzene [6]. (thefreedictionary.com)
  • Reduction of benzoquinones to hydroquinones via spontaneous reaction with glutathione and enzymatic reaction by S-glutathionyl-hydroquinone reductases. (openrepository.com)
  • Hydroquinone and benzoquinone. (docplayer.net)
  • The oxidative dearomatization of phenols bearing amino alcohol groups induced N-cyclization to afford ortho-benzoquinone monohemiaminals. (elsevier.com)
  • Conversion of pentahalogenated phenols by microperoxidase-8/h202 to benzoquinone type products. (wur.nl)
  • This learning unit explains the mechanism of the oxidation of phenols to benzoquinones. (chemgapedia.de)
  • 1,2-Benzoquinone, also called ortho-benzoquinone, is an organic compound with formula C6H4O2. (wikipedia.org)
  • Formation of ortho-benzoquinone from sodium benzoate by Pseudomonas mendocina P2d" (PDF). (wikipedia.org)
  • The preparation and reactions of ortho-benzoquinone monohemiaminals are described. (elsevier.com)
  • The chiral ortho-benzoquinone monohemiaminal undergoes stereoselective Diels-Alder reactions with electron-deficient alkenes, as expected, confirming the promising utility of ortho-benzoquinone monohemiaminals. (elsevier.com)
  • Abstract 1788: 19-Substituted benzoquinone ansamycins. (aacrjournals.org)
  • abstract = "In this study, the poly-vinylidene fluoride (PVDF)/p-benzoquinone (pBQ) gel polymer electrolyte (GPE) is synthesized well with LiTFSI/TEGDME for Li-Air battery (LAB) applications. (elsevier.com)
  • The first objective of this study was to determine if exposure of fetal hematopoietic cells to p-benzoquinone, a known toxic metabolite of benzene, increased DNA recombination in the pKZ1 model of mutagenesis. (queensu.ca)
  • Benzoquinone compounds are a metabolite of paracetamol. (wikipedia.org)
  • Occupational exposure to para- benzoquinone dioxime probably occurs during its manufacture, its use as a rubber vulcanizing agent and its conversion to chemical derivatives. (inchem.org)
  • 2. One of a class of benzoquinone derivatives. (thefreedictionary.com)
  • 1] have reported the synthesis of a compound similar to 2 , which has a saturated ethano bridged between the 2,2'-bipyridine and the para-benzoquinone moiety. (mdpi.com)
  • Nikitina, A. 2004-10-13 00:00:00 A procedure was developed for synthesis of a new monomer from monoethanolamine vinyl ether and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone. (deepdyve.com)
  • Synthesis and structural elucidation of various glutathione addition products to 1,4-benzoquinone. (openrepository.com)
  • The benzoquinones of the invention have various potential applications in pharmaceutical and cosmetic industry (namely as antioxidants, anti-ageing agents and the like), in organic synthesis, metal complexations, metal separations, potentiometric titrations, interfacial catalysis, and ion-transfer reactions across biological membranes. (edu.mk)
  • Regioselective Synthesis of Bicyclic and Polycyclic Systems by Cycloaddition Reactions of Alkenyl p-Benzoquinones. (nih.gov)
  • Unsubstituted zinc phthalocyanine, 1, 3-diphenylisobenzofuran (DPBF), and 1,4-benzoquinone (BQ) were purchased from Sigma Aldrich. (thefreedictionary.com)
  • Using cyclic voltammetry, the electrochemistry of aqueous solutions of 4-methoxy-1,2-benzoquinone was investigated over the pH range 0-8. (edu.au)
  • The production of these benzoquinones comprises the reaction of dimethoxy benzoquinones with highly alkaline aqueous solutions. (edu.mk)
  • Inhibition of Glucose-6-Phosphate Dehydrogenase Could Enhance 1,4-Benzoquinone-Induced Oxidative Damage in K562 Cells," Oxidative Medicine and Cellular Longevity , vol. 2016, Article ID 3912515, 11 pages, 2016. (hindawi.com)
  • Secondly, this study determined if exposure of fetal hematopoietic cells to p-benzoquinone resulted in DNA damage using γ-H2A.X as a marker for DNA double strand breaks and 8-hydroxy-2'-deoxyguanosine as a marker of oxidative DNA damage. (queensu.ca)
  • Exposure of fetal hematopoietic cells to 25 μM p-benzoquinone did not significantly increase oxidative DNA damage at any of the examined time points. (queensu.ca)
  • These studies indicate that p-benzoquinone is able to induce DNA damage and recombination in fetal hematopoieitic cells and that reactive oxygen species and oxidative stress may be important in the mechanism of toxicity. (queensu.ca)
  • Herbimycin A, geldanamycin, and certain other benzoquinone ansamycins display an unusual capacity to revert tyrosine kinase-induced oncogenic transformation. (pnas.org)
  • It was observed that simple hydroquinones were not formed when the different benzoquinones were mixed with excess GSH and suggests that the initial reaction is addition/reduction rather than electron transfer. (openrepository.com)
  • 1,4-Benzoquinone is sold by chemical suppliers. (sciencemadness.org)
  • Photocatalytic degradation of 1,4-Benzoquinone in aqueous ZnO dispersions," Journal of the Brazilian Chemical Society, vol. (thefreedictionary.com)
  • We are counted as a leading Manufacturer, Exporter and Supplier of reliable industrial chemical like P-Benzoquinone, Para Benzoquinone, etc . (gajananenterprises.co.in)
  • There is limited evidence that para- benzoquinone dioxime is carcinogenic to rats. (inchem.org)
  • Benzoquinone is probably carcinogenic. (sciencemadness.org)
  • To elucidate the impact of benzoquinone (BQ) on lipid homeostasis and cytotoxicity in Saccharomyces cerevisiae . (rsc.org)
  • Sorghum bicolor is considered to be an allelopathic crop species, producing phytotoxins such as the lipid benzoquinone sorgoleone, which likely accounts for many of the allelopathic properties of Sorghum spp. (plantcell.org)
  • Benzoquinone readily undergoes sublimation, even at room temperature. (sciencemadness.org)
  • Ubiquinone-1 is a naturally occurring 1,4-benzoquinone that is involved in respiration apparatus. (wikipedia.org)
  • Strongly oxidizing quinones include chloranil and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (also known as DDQ). (wikipedia.org)
  • 1,4-Benzoquinone or p-benzoquinone is the basic structure of quinonoid compounds.They are widely distributed in the natural world, being found in bacteria, plants and arthropods and hence quinones are ubiquitous to living systems. (chemicalbook.com)
  • 1,4-Benzoquinone is sensitive toward both strong mineral acids and alkali, which cause condensation and decomposition of the compound. (sciencemadness.org)
  • These were shown to be due to 2-hydroxy-1,4-benzoquinone, formed by hydrolysis of the original compound. (edu.au)
  • Our collection of P-Benzoquinone, Para Benzoquinone, etc is a yellow to green crystal in solid form with pungent odor and significant vapor pressure. (gajananenterprises.co.in)
  • The invention relates to a new type of highly polar, at least double-negatively charged redox-active benzoquinones, notably derived from Coenzyme Q0, Q1 and dimethoxy benzoquinones, its production and use. (edu.mk)
  • To determine which metabolites of arachidonic acid stimulated the release of β-end-IR, we examined the effects of an inhibitor of the cyclooxygenase, indomethacin, and an inhibitor of the 5-lipoxygenase, 2,3,5- trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-l,4-benzoquinone . (acronymattic.com)
  • The hydrolysis reaction was shown to be first order both with respect to the 1,2-benzoquinone and protons. (edu.au)
  • A significant increase in γ-H2A.X foci formation was observed following exposure to 25 μM p-benzoquinone for 30 min, 45 min and one hour. (queensu.ca)
  • The disodium salt of 2,5-dihydroxy-1,4-benzoquinone has been prepared and proposed as anode material for rechargeable sodium ion batteries for the first time, showing an average operation voltage of ∼1.2 V, a reversible capacity of ∼265 mA h g −1 , a long cycle life (300 cycles), and high rate capability. (rsc.org)
  • para- Benzoquinone dioxime was tested for carcinogenicity at two dose levels in mice and rats by oral administration. (inchem.org)
  • Department of Occupational en Environmental Dermatology, University Hospital, S-205 02 Malmö. (springer.com)
  • Hartre-Fock calculations showed that the anion negative charge was located mostl Показать полностью y on the oxygen of hydroxyl group, while estimation of the total energy of the alkylated products pointed out the benefit of alkylation on the oxygen atom of the nitroso group yielding p-benzoquinone monoxime alkyl ethers. (sfu-kras.ru)
  • Coenzyme Q10 (or 1,4-benzoquinone ) is a component of the electron transport chain in mitochondria which is linked to the generation of energy in the cell (Bentinger et al. (thefreedictionary.com)
  • Excited-state electron and energy transfer from singlet excited rubrene (Ru) to benzoquinone (BQ) and tetra-(4-aminophenyl) porphyrin (TAPP) were investigated by steady-state absorption and emission, time-resolved transient absorption, and femtosecond (fs)-nanosecond (ns) fluorescence spectroscopy. (edu.sa)
  • This paper describes voltammetric method for determination of TDZ via its reduction at a 1,4-benzoquinone modified carbon paste electrode (1,4-BQMCPE). (thefreedictionary.com)
  • Protein targets of 1,4-benzoquinone and 1,4-naphthoquinone in human bronchial epithelial cells. (thefreedictionary.com)
  • Additionally, pretreatment with 400 U/mL PEG-catalase, an antioxidative enzyme, attenuated the increases in both DNA recombination and DNA double strand breaks as compared to treatment with p-benzoquinone alone. (queensu.ca)
  • The report also focuses on para-benzoquinone(pbq) consumers by providing data on companies that use it. (marketpublishers.com)
  • The report also focuses on 2,5-di-tert-butyl-p-benzoquinone consumers by providing data on companies that use it. (marketpublishers.com)