Benzopyrenes: A class of chemicals that contain an anthracene ring with a naphthalene ring attached to it.Polycyclic Hydrocarbons, Aromatic: A major group of unsaturated cyclic hydrocarbons containing two or more rings. The vast number of compounds of this important group, derived chiefly from petroleum and coal tar, are rather highly reactive and chemically versatile. The name is due to the strong and not unpleasant odor characteristic of most substances of this nature. (From Hawley's Condensed Chemical Dictionary, 12th ed, p96)Polycyclic Compounds: Compounds consisting of two or more fused ring structures.Occupational Exposure: The exposure to potentially harmful chemical, physical, or biological agents that occurs as a result of one's occupation.Gasoline: Volative flammable fuel (liquid hydrocarbons) derived from crude petroleum by processes such as distillation reforming, polymerization, etc.Pyrenes: A group of condensed ring hydrocarbons.HydrocarbonsBenzo(a)pyrene: A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.VirginiaConstruction Materials: Supplies used in building.KansasPsychomotor Agitation: A feeling of restlessness associated with increased motor activity. This may occur as a manifestation of nervous system drug toxicity or other conditions.Color Perception Tests: Type of vision test used to determine COLOR VISION DEFECTS.National Institute for Occupational Safety and Health (U.S.): An institute of the CENTERS FOR DISEASE CONTROL AND PREVENTION which is responsible for assuring safe and healthful working conditions and for developing standards of safety and health. Research activities are carried out pertinent to these goals.Deoxyguanosine: A nucleoside consisting of the base guanine and the sugar deoxyribose.Tissue Distribution: Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.Lung: Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.Acyl-Carrier Protein S-Acetyltransferase: A enzyme that catalyzes the transfer of acetyl groups from ACETYL CoA to acyl-carrier protein to form COENZYME A and acetyl-acyl-carrier protein.Prostaglandins H: A group of physiologically active prostaglandin endoperoxides. They are precursors in the biosynthesis of prostaglandins and thromboxanes. The most frequently encountered member of this group is the prostaglandin H2.Lyases: A class of enzymes that catalyze the cleavage of C-C, C-O, and C-N, and other bonds by other means than by hydrolysis or oxidation. (Enzyme Nomenclature, 1992) EC 4.Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.Pregnancy Complications: Conditions or pathological processes associated with pregnancy. They can occur during or after pregnancy, and range from minor discomforts to serious diseases that require medical interventions. They include diseases in pregnant females, and pregnancies in females with diseases.Pregnancy Outcome: Results of conception and ensuing pregnancy, including LIVE BIRTH; STILLBIRTH; SPONTANEOUS ABORTION; INDUCED ABORTION. The outcome may follow natural or artificial insemination or any of the various ASSISTED REPRODUCTIVE TECHNIQUES, such as EMBRYO TRANSFER or FERTILIZATION IN VITRO.Multilingualism: The ability to speak, read, or write several languages or many languages with some facility. Bilingualism is the most common form. (From Random House Unabridged Dictionary, 2d ed)Pregnancy, Animal: The process of bearing developing young (EMBRYOS or FETUSES) in utero in non-human mammals, beginning from FERTILIZATION to BIRTH.Smoking: Inhaling and exhaling the smoke of burning TOBACCO.Language: A verbal or nonverbal means of communicating ideas or feelings.Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.Muscle Relaxants, Central: A heterogeneous group of drugs used to produce muscle relaxation, excepting the neuromuscular blocking agents. They have their primary clinical and therapeutic uses in the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. They have been used also for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in MULTIPLE SCLEROSIS. (From Smith and Reynard, Textbook of Pharmacology, 1991, p358)Substance Abuse Detection: Detection of drugs that have been abused, overused, or misused, including legal and illegal drugs. Urine screening is the usual method of detection.Hair Preparations: Hair grooming, cleansing and modifying products meant for topical application to hair, usually human. They include sprays, bleaches, dyes, conditioners, rinses, shampoos, nutrient lotions, etc.Methenolone: A synthetic steroid that has been used for its anabolic action.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)International Agencies: International organizations which provide health-related or other cooperative services.Carcinogens, Environmental: Carcinogenic substances that are found in the environment.Legislation, Drug: Laws concerned with manufacturing, dispensing, and marketing of drugs.Carcinogens: Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.Chrysenes: 1,2-Benzphenanthrenes. POLYCYCLIC COMPOUNDS obtained from coal tar.Iris: The most anterior portion of the uveal layer, separating the anterior chamber from the posterior. It consists of two layers - the stroma and the pigmented epithelium. Color of the iris depends on the amount of melanin in the stroma on reflection from the pigmented epithelium.United States Environmental Protection Agency: An agency in the Executive Branch of the Federal Government. It was created as an independent regulatory agency responsible for the implementation of federal laws designed to protect the environment. Its mission is to protect human health and the ENVIRONMENT.7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide: 7,8,8a,9a-Tetrahydrobenzo(10,11)chryseno (3,4-b)oxirene-7,8-diol. A benzopyrene derivative with carcinogenic and mutagenic activity.Erythrocytes: Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.Anemia: A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.Micronucleus Tests: Induction and quantitative measurement of chromosomal damage leading to the formation of micronuclei (MICRONUCLEI, CHROMOSOME-DEFECTIVE) in cells which have been exposed to genotoxic agents or IONIZING RADIATION.o-Chlorobenzylidenemalonitrile: A riot control agent which causes temporary irritation of the eyes and the mucosal surface of the respiratory tract. It is a more potent irritant than OMEGA-CHLOROACETOPHENONE, but less incapacitating.Erythrocyte Membrane: The semi-permeable outer structure of a red blood cell. It is known as a red cell 'ghost' after HEMOLYSIS.Micronuclei, Chromosome-Defective: Defective nuclei produced during the TELOPHASE of MITOSIS or MEIOSIS by lagging CHROMOSOMES or chromosome fragments derived from spontaneous or experimentally induced chromosomal structural changes.Antimutagenic Agents: Agents that reduce the frequency or rate of spontaneous or induced mutations independently of the mechanism involved.Ozone: The unstable triatomic form of oxygen, O3. It is a powerful oxidant that is produced for various chemical and industrial uses. Its production is also catalyzed in the ATMOSPHERE by ULTRAVIOLET RAY irradiation of oxygen or other ozone precursors such as VOLATILE ORGANIC COMPOUNDS and NITROGEN OXIDES. About 90% of the ozone in the atmosphere exists in the stratosphere (STRATOSPHERIC OZONE).Fellowships and Scholarships: Stipends or grants-in-aid granted by foundations or institutions to individuals for study.Breakfast: The first meal of the day.Oxidants, Photochemical: Compounds that accept electrons in an oxidation-reduction reaction. The reaction is induced by or accelerated by exposure to electromagnetic radiation in the spectrum of visible or ultraviolet light.Exhibits as Topic: Discussions, descriptions or catalogs of public displays or items representative of a given subject.Smoke-Free Policy: Prohibition against tobacco smoking in specific areas to control TOBACCO SMOKE POLLUTION.Policy: A course or method of action selected to guide and determine present and future decisions.

The direct spectrophotometric observation of benzo(a)pyrene phenol formation by liver microsomes. (1/611)

Optical spectral repetitive scan analysis during the oxidative metabolism of benzo(a)pyrene by liver microsomal suspensions reveals the time-dependent formation of an intermediate(s) of which the visible spectra resemble those of several benzo(a)pyrene phenols. Liver microsomes from 3-methylcholanthrene-treated rats showed a greater rate of formation of the phenols than did microsomes from control animals; the rate of formation catalyzed by liver microsomes from phenobarbital-pretreated rats was intermediate. When 3-hydroxybenzo(a)pyrene was used as a standard for comparison of activity, the rates of formation of phenols were compared when measured by fluorometric, spectrophotometric, or high-pressure liquid chromatographic analytical techniques. An epoxide hydrase inhibitor, 1,1,1-trichloropropene-2,3-oxide, enhanced phenol formation regardless of the source of liver microsomes, and 7,8-benzoflavone inhibited control and 3-methylcholanthrene-induced microsomal metabolism of benzo(a)pyrene, 7,8-Benzoflavone did not effect benzo(a)pyrene metabolism by liver microsomes from phenobarbital-pretreated rats. The effect of inhibitors on the spectrophotometric assay correlates well with the results obtained from benzo(a)pyrene metabolite analysis using high-pressure liquid chromatography.  (+info)

Differences in benzo(a)pyrene metabolism between rodent liver microsomes and embryonic cells. (2/611)

Differences in benzo(a)pyrene metabolite pattern have been shown by rodent liver microsomes (Sprague-Dawley) and rodent embryo cells from Syrian hamsters and NIH Swiss mice. Rodent liver induced by methylcholanthrene shows marked quantitative variation between species. Additional pattern changes were found in mouse and hamster embryo secondary cultures with a reduction of the K-region metabolites and a marked increase in 9-hydroxybenzo(a)-pyrene. These results are indicative of a region-specific attack on the carcinogen by the cell monooxygenases which is distinct from the liver attack of microsomal enzymes on benzo(a)pyrene. These results suggest that activation and detoxification of benzo(a)pyrene may be species and tissue variable, and susceptibility and resistence to malignant transformation may be predicted on induction of a fortuitous combination of intermediate metabolic steps.  (+info)

Formation in isolated rat liver microsomes and nuclei of benzo(a)pyrene metabolites that bind to DNA. (3/611)

The hepatic nuclear fraction isolated from 3-methylcholanthrene (MC)-treated rats contained enhanced levels of cytochrome P-450 and aryl hydrocarbon hydroxylase [benzo(a)pyrene (BP) monooxygenase], whereas the activities of epoxide hydrase and reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase and the concentration of cytochrome b5 were not altered. The metabolite pattern of BP was investigated by using high-pressure liquid chromatography and was found to be similar in nuclei and microsomes from MC-treated rats. After incubation of the nuclear fraction with [3H]BP and reduced nicotinamide adenine dinculeotide phosphate, radioactivity was found to be associated with nuclear DNA and the extent of binding was markedly enhanced by pretreatment of the animals with MC. Binding was strongly inhibited by a-napthoflavone but was not influenced by 1,1,1-trichloropropene-2,3-oxide, an inhibitor of epoxide hydrase. In the presence of microsomes from MC-treated rats, increased binding of BP to DNA was observed in nuclei from both control and MC-treated rats; moreover, when the nuclear DNA was replaced by a corresponding amount of calf thymus DNA, the extent of binding was severalfold enhanced. In contrast to nuclei from control rats, the nuclear fraction from MC-treated rats showed an increase in bound radioactivity when incubated with a microsome-free supernatant, obtained by incubating microsomes from MC-treated rats with [3H]BP. The increase in extent of binding was eliminated in the presence of menadione or alpha-naphthoflavone. It is suggested that under the conditions used here the following different processes may have contributed to the total incorporation of BP products into nuclear DNA: (a) formation of DNA-binding products derived from BP by nuclear aryl hydrocarbon hydroxylase; (b) formation of DNA-binding products from microsomal BP metabolites by nuclear aryl hydrocarbon hydroxylase; and (c) direct transfer of reactive microsomal metabolites to nuclear DNA.  (+info)

Nonenzymatic reduction of benzo(a)pyrene diol-epoxides to trihydroxypentahydrobenzo(a)pyrenes by reduced nicotinamide adenine dinucleotide phosphate. (4/611)

The diol-epoxide r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene is a potent mutagen and possibly the ultimate carcinogenic form of benzo(a)pyrene. A (7/8,9)-trihydroxy-7,8,9,10,10-pentahydrobenzo(a)pyrene is formed from the diol-epoxide r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydroxybenzo(a)pyrene by reduction with reduced nicotinamide adenine dinucleotide phosphate. Its formation is linear with reduced nicotinamide adenine dinucleotide phosphate concentration and does not require the presence of enzyme. A (7,9/8)-trihydroxy-7,8,9,10,10-pentahydrobenzo(a)pyrene is similarly formed from the diol-epoxide r-7,t-8-dihydroxy-c-9,10-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene by reduction with reduced nicotinamide adenine dinucleotide phosphate. The structures of the trihydroxypentahydrobenzo(a)pyrenes were established by their ultraviolet absorption and mass spectra and their reaction with potassium triacetylosmate.  (+info)

Use of tracheal organ cultures in toxicity testing. (5/611)

Fragments of tracheal epithelium alone or in continuity with connective tissues, can be maintained in culture medium and used for short term or long term studies of toxicity of a variety of chemicals. Large numbers of uniform cultures are prepared with the aid of a slicing device or by application of simple method for dissecting sheets of epithelium free from underlying cartilage. The cultures may be placed in an exposure chamber-incubator mounted on a microscope stage and monitored continually for ciliostasis and exfoliation of cells. Morphology is further studied by fixation of selected specimens and preparation for light microscopy and electron microscopy. Synthetic functions are evaluated by autoradiographic measurement of incorporation of radioactive precursors into macromolecules and other dynamic features are indirectly assessed by histochemical and histoenzymatic methods. Short-term studies using these several techniques have shown that ciliostasis does not correlate with cell injury in all instances, and a long-term study has demonstrated dose dependence of a cytotoxic agent when duration of culture viability is measured. The method lends itself to a broad range of investigations in which dose, period of exposure, and role of cofactors must be independently and quantitatively assessed.  (+info)

Biochemical studies of isolated hamster tracheal epithelium. (6/611)

The epithelial lining of respiratory air passageways is a primary target tissue for toxicity and carcinogenesis in man and in animal models of human disease. The importance of this target tissue was the basis for development of methods to study its biochemistry, and with this information to distinguish the unique properties of this tissue from properties common to all cell types. Biochemical methods employed labeling of macromolecules in isolated hamster treacheas during brief (less than 4 hr) incubation in vitro. Studies of RNA metabolism in isolated tracheas demonstrated a pattern of maturation of ribosomal RNA like that shown for other cell types. Alterations in RNA metabolism were observed in isolated tracheas obtained from vitamin A-deficient hamsters and hamsters previously treated by intratracheal administration of benzo[a]pyrene (BP) plus ferric oxide (Fe2O3) in vivo. Studies with toyocamycin, actinomycin D, and alpha-amanitin, all inhibitors of RNA metabolism, were performed to characterize the class of RNA molecules with a decreased proportion of labeling in tracheas from vitamin A deficient hamsters. In another series of experiments, BP was shown to bind to DNA in epithelial cells of isolated tracheas. The quantity of BP binding was increased by prior intratracheal treatment of hamsters with BP plus Fe2O3 in vivo, this induced binding was inhibited by addition of 7,8-benzoflavone to the incubation medium. Increased BP binding was also observed in isolated tracheas from hamsters believed to be in states of increased susceptibility to respiratory carcinogenesis in vivo. The results show that biochemical studies are feasible with this tissue. Furthermore, a number of questions of importance with regard to this target epithelium are best studied directly in its constituent cells.  (+info)

Comparison of cytochrome P450- and peroxidase-dependent metabolic activation of the potent carcinogen dibenzo[a,l]pyrene in human cell lines: formation of stable DNA adducts and absence of a detectable increase in apurinic sites. (7/611)

The potent carcinogen dibenzo[a,l]pyrene (DB[a,l]P) has been reported to form both stable and depurinating DNA adducts upon activation by cytochrome P450 enzymes and/or cellular peroxidases. Only stable DB[a,l]P-DNA adducts were detected in DNA after reaction of DB[a,I]P-11,12-diol-13,14-epoxides in solution or cells in culture. To determine whether DB[a,l]P can be activated to metabolites that form depurinating adducts in cells with either high peroxidase (human leukemia HL-60 cell line) or cytochrome P450 activity (human mammary carcinoma MCF-7 cell line), cultures were treated with DB[a,l]P for 4 h, and the levels of stable adducts and apurinic (AP) sites in the DNA were determined. DNA samples from DB[a,l]P-treated HL-60 cells contained no detectable levels of either stable adducts or AP sites. MCF-7 cells exposed to 2 microM DB[a,l]P for 4 h contained 4 stable adducts per 10(6) nucleotides, but no detectable increase in AP sites. The results indicate that metabolic activation of DB[a,l]P by cytochrome P450 enzymes to diol epoxides that form stable DNA adducts, rather than one-electron oxidation catalyzed either by cytochrome P450 enzymes or peroxidases to form AP sites, is responsible for the high carcinogenic activity of DB[a,l]P.  (+info)

Pathologic changes induced in respiratory tract mucosa by polycyclic hydrocarbons of differing carcinogenic activity. (8/611)

Seven aromatic polycyclic hydrocarbons (PCHs) were investigated for their toxic effects on respiratory mucosa: benzo(e)pyrene (BeP), pyrene, anthracene, benz(a)anthracene(BaA), dibenz(a,c)anthracene(DBacA), benzo (a)pyrene (BaP), and dimethylbenz(a)anthracene (DMBA). The compounds were chosen because they comprise a spectrum of PCHs ranging from noncarcinogens, to initiators, to weak and strong carcinogens. All of them except DMBA are environmentally relevant chemicals. The chemicals were tested over an 8-week period. Heterotopic tracheal transplants were continously exposed and the histopathologic effects induced by the various PCHs were periodically assessed semiquantitatively. All PCHs exhibited varying degrees of toxicity for respiratory epithelium and submucosa. BeP clearly showed the least toxicity followed by pyrene and anthracene. BaA and DBacA caused marked epithelial and submucosal changes. In addition to epithelial hyperplasia, undifferentiated epithelium and squamous metaplasia developed. Marked mononuclear infiltration occurred in the subepithelial connective tissue. With BaP the epithelial and submucosal changes were similar but were much stronger. DMBA was the most toxic substance, causing epithelial necrosis followed by generalized keratinizing squamous metaplasia; the subepithelial changes consisted of an early acellular exudate and, later (at 8 weeks), marked condensation and hyalinization of the lamina propria. The toxic response pattern of the tracheal mucosa to carcinogenic agents was characterized by the chronicity of epithelial and connective tissue damage, as opposed to the short-lived hyperplastic and inflammatory response elicited by the noncarcinogens and weak initiators.  (+info)

Stereoselective metabolism of dibenzo[a,l]pyrene (DB[a,l]P), 2-chlorodibenzo[a,l]pyrene (2-Cl-DB[a,l]P) and 10-chlorodibenzo[a,l]pyrene (10-Cl-DB[a,l]P) by rat liver microsomes was studied and effects of the chloro substituent on the metabolism were determined. All three compounds produced trans-8,9-dihydrodiol, trans-11,12-dihydrodiol, and the 7-hydroxyl derivative as major metabolic products and several other phenolic derivatives as minor metabolites. The trans-8,9- and 11,12-dihydrodiols of DB[a,l]P and 2-Cl-DB[a,l]P preferentially adopted a quasidiequatorial conformation, whereas 10-Cl-DB[a,l]P trans-8,9- and 11,12-dihydrodiols preferentially adopted a quasidiaxial conformation. The yields of the trans-11,12-dihydrodiol metabolites are: DB[a,l]P trans-11,12-dihydrodiol | 2-Cl-DB[a,l]P trans-11,12-dihydrodiol || 10-Cl-DB[a,l]P trans-11,12-dihydrodiol. Circular dichroism (CD) spectral analysis indicates that the trans-8,9-dihydrodiol and trans-11,12-dihydrodiol metabolites from DB[a,l]P, 2-Cl-DB[a,l]P
Words Ending In ene: acetylene,achene,advene,agene,akene,alkene,amene,aminobutene,amylene,anadyomene,anthracene,antigene,antivenene,arrasene,azobenzene,bene,benzanthracene,benzene,benzoapyrene,benzopyrene,benzpyrene,buckm
Siddens LK, Larin A, Krueger SK, Bradfield CA, Waters KM, Tilton SC, Pereira CB, Lohr CV, Arlt VM, Phillips DH, Williams DE and Baird WM (2012). Polycyclic aromatic hydrocarbons as skin carcinogens: Comparison of benzo[a]pyrene, dibenzo[def,p]chrysene and three environmental mixtures in the FVB/N mouse. Toxicology and Applied Pharmacology doi: 10.1016/j.taap.2012.08. ...
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
70133-84-5 - JZLWANHLFXZFCU-UHFFFAOYSA-N - 2-Chloro-12-(2-piperidinoethyl)dibenzo(d,g)-1,3,6-dioxazocine - Similar structures search, synonyms, formulas, resource links, and other chemical information.
Pyrene derivatives can be carcinogenic, teratogenic and mutagenic, thus having the potential to cause malignant diseases. In this work, the interactions of two selected pyrene derivatives (1-OHP and 1-PBO) and human tumor-related DNA (p53 DNA and C-myc DNA) are investigated by spectroscopic and non-native polyacrylamide gel electrophoresis (PAGE) methods. Using fluorescence spectrometry and circular dichroism (CD), DNA interactions of pyrene derivatives are confirmed to occur mainly via the groove binding mode supported by the intercalation into the base pairs of DNA. There is an obvious binding order of pyrene derivatives to the targeted DNA, 1-OHP | 1-PBO. The binding constants of 1-OHP are 1.16 × 106 L×mol−1 and 4.04 × 105 L×mol−1 for p53 DNA and C-myc DNA, respectively, while that of 1-PBO are only 2.04 × 103 L×mol−1 and 1.39 × 103 L×mol−1 for p53 DNA and C-myc DNA, respectively. Besides, the binding of pyrene derivatives to p53 DNA is stronger than that for C-myc DNA. CD and PAGE
TY - JOUR. T1 - Binding of isomers of benzo[a]pyrene diol-epoxide to chromatin. AU - Kootstra, A.. AU - Slaga, T. J.. PY - 1980/4/14. Y1 - 1980/4/14. N2 - Both the carcinogenic B[a]P diol-epoxide (anti) and its relatively noncarcinogenic isomer, B[a]P diol-epoxide (syn), when reacted with chromatin in vitro, bind more extensively to the internucleosomal region of chromatin than to nucleosomes. These results suggest that the increased binding of B[a]P diol-epoxide (anti) to the internucleosomal region may have little relevance to the process of carcinogenesis.. AB - Both the carcinogenic B[a]P diol-epoxide (anti) and its relatively noncarcinogenic isomer, B[a]P diol-epoxide (syn), when reacted with chromatin in vitro, bind more extensively to the internucleosomal region of chromatin than to nucleosomes. These results suggest that the increased binding of B[a]P diol-epoxide (anti) to the internucleosomal region may have little relevance to the process of carcinogenesis.. UR - ...
When [3H]benzo[a]pyrene is incubated in vitro together with deproteinized salmon sperm DNA, NADPH, and mouse liver microsomes, the covalent binding of benzo[a]pyrene metabolites to DNA occurs. The metabolite-nucleoside complexes can be resolved into at least nine distinct peaks by elution of a Sephadex LH-20 column with a water-methanol gradient. These peaks are arbitrarily designated A (most polar) through I (least polar). With the use of synthetic and biologically produced metabolites, seven of nine peaks are tentatively assigned to one or more metabolites of benzo[a]pyrene. Peaks A and C are unidentified. Peaks B, D, F, and I include products of benzo[a]pyrene quinones that are further metabolized. Peak E reflects almost exclusively both the cis- and trans-7,8-diol 9,10-epoxides of benzo[a]pyrene. Peak G represents predominantly the K-region metabolite (the 4,5-oxide), interacting with one or more nucleosides. Peak H comprises reactive intermediates resulting from the further metabolism of ...
Butylated hydroxyanisole (BHA) is a commonly used food additive with demonstrated inhibitory action against chemical carcinogenesis in animals. In order to elucidate the mechanism of the anticarcinogenic action, the effects of BHA on benzo(a)pyrene (BP) metabolism were studied with lung microsomes from female mice. BHA treatment (0.5% in the diet for 7 days) inhibited BP metabolism and altered the ratios among different metabolites as analyzed by high-performance liquid chromatography. The treatment reduced the metabolic formation of 9,10-dihydroxy-9,10-dihydrobenzo(a)pyrene, but not the production of 3-hydroxybenzo(a)pyrene and trans-4,5-dihydroxy-4,5-dihydrobenzo(a)pyrene. Since the gross microsomal cytochrome P-450 content was not significantly affected by the treatment, the change of regioselectivity in BP metabolism was probably due to the alteration of cytochrome P-450 isozyme composition by dietary BHA. General and regioselective inhibition of BP metabolism was also observed when BHA was ...
Advertisement In utero Exposure of Mice to Dibenzo[a,l]Pyrene Produces Lymphoma in the Offspring: Role of the Aryl Hydrocarbon Receptor
Levin, W; Wood, A W.; Wislocki, P G.; Kapitulnik, J; Yagi, H; Jerina, D M.; and Conney, A H., "Carcinogenicity of benzo-ring derivatives of benzo(a)pyrene on mouse skin." (1977). Subject Strain Bibliography 1977. 715 ...
An enzyme immunoassay for the detection of benzo[a]pyrene covalently conjugated to macromolecules has been developed. The monoclonal antibody, raised through in vitro immunization reacted with benzo[a]pyrene metabolites bound to DNA, RNA and proteins. The lower detection limit for the assay was 1 pmol for benzo[a]pyrene bound to DNA or RNA, and 5 pmol when bound to protein.
CAS NO:192-97-2; Chemical name:benzo[e]pyrene ; physical and chemical property of 192-97-2, benzo[e]pyrene is provided by ChemNet.com
4.1 Polymorphisms and mutations are both variations in DNA sequence and can arise through the same mechanisms. We use the term polymorphism to refer to DNA variants that are relatively common in populations. Mutations affect the phenotype.. 4.2 Misreading of bases during replication can lead to substitution and can be caused by things like tautomerism, DNA alkylating agents, and irradiation.. 4.3 Looping out of DNA on the template strand during replication; strand breakage, due to radiation and other mutagens; and (discussed in earlier chapters) chromosomal aberrations such as deletions and translocations.. 4.4 Looping out of DNA on the growing strand during replication; transposition; and (discussed in earlier chapters) chromosomal aberrations such as duplications, insertions, and translocation.. 4.5 Benzopyrene is one of many hazardous compounds present in smoke. Benzopyrene is an intercalating agent, which slides between the bases of the DNA molecule, distorting the shape of the double helix, ...
You are viewing an interactive 3D depiction of the molecule 9-(2-deoxy-5-o-phosphonopentofuranosyl)-n-(7,8,9-trihydroxy-7,8,9,10-tetrahydrobenzo[pqr]tetraphen-10-yl)-9h-purin-6-amine (C30H14N5O9P) from the PQR.
Creative-Proteomics offer cas 192-65-4 DIBENZO[A,E]PYRENE UNLABELED. We are specialized in manufacturing Stabel Isotope Labeled Analytical Standard products.
The present study shows the effect of combined dietary deprivation of fat and vitamin A on benzo(a)pyrene (BaP) induced lung carcinogenesis in male Wistar rats. Lung tumors were induced by intratracheal instillation of BaP-Fe2O3 in normal saline. The tumor incidence and tumor burden in control animals were 82% and 2.28 respectively. Fat deficiency decreased the tumor incidence to 57% and tumor burden to 1.66. On the other hand, in vitamin A deficiency these were 83% and 4.02 respectively. Fat deprivation in the diet of animals fed with vitamin A deficient diet decreased the tumor incidence and tumor burden to 69.6% and 2.7 respectively. The results suggest a protective role of low intake of fat in vitamin A deficiency for BaP-induced lung tumorigenesis in rats.
Zaleski, J; Bansal, S K.; and Gessner, T, "Formation of glucuronide, sulphate and glutathione conjugates of benzo[a]pyrene metabolites in hepatocytes isolated from inbred strains of mice." (1983). Subject Strain Bibliography 1983. 1888 ...
Dibenzo[b,e]Thiepin-11(6H)-One 1531-77-7 MSDS report, Dibenzo[b,e]Thiepin-11(6H)-One MSDS safety technical specifications search, Dibenzo[b,e]Thiepin-11(6H)-One safety information specifications ect.
6-methoxy-1,5-dihydrobenzo[cd]indol-4(3H)-one - chemical structural formula, chemical names, chemical properties, synthesis references
Phenylethynylpyrene (PEP) is a pyrene derivative with red-shifted absorption and emission spectra. Fits blue channel of qPCR instruments, can be used for multiplex experiments.
Trichloroepoxypropane: A potent epoxide hydrase and aryl hydrocarbon hydroxylase inhibitor. It enhances the tumor-initiating ability of certain carcinogens.
dibenzo[b,d]furan-2-carbaldehyde | C13H8O2 | CID 220843 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Zelen j l - p rodn prost edek pro zdrav a kr su - J l je jednou z nejstar ch surovin, kter lov k za al vyu vat. A v kosmetice? - Redakce
E er karaci er absesi bakteriden kaynaklan yorsa, doktor ak t l p temizlenmesi i in kateterizasyon ve be hafta damardan antibiyotik verilmesini nerebilir. Bazen cerrahi m dahal
Aryl hydrocarbon hydroxylase (AHH) was induced 15-fold in Ambystoma tigrinum by intraperitoneal injection of 3-methylcholanthrene in corn oil, or 10-fold by addition of aromatic polycyclic hydrocarbons to the aqueous environment of the neotene animal. The cytochrome P-450-associated microsomal enzyme is similar to the inducible, one-gene, autosomal-dominant system typical in the laboratory mouse and man. Differences in optimal temperature for enzyme induction and activity were noted in organ culture of human and Ambystoma tissues, and ratios of benzpyrene metabolites differed between Ambystoma and Mus. The half life of enzyme activity induced in vivo was related to the excretion of hydrocarbon metabolites.
Effects of five organic solvent vehicles on benzo(a)pyrene- hydroxylase (BP-hydroxylase) activity and on the benzo(a)pyrene (50328) (BP) metabolite profile were studied in lung microsomes prepared from male New Zealand white rabbits. The production of 3- OH-benzo(a)pyrene (13345216) and 9-OH-benzo(a)pyrene (17573216) was used to evaluate the effects of dimethyl-sulfoxide (DMSO), acetone, methanol,
Two diol-epoxide metabolites of benzo[c]phenanthrene and benzo[a]pyrene, polynuclear aromatic hydrocarbons which occur in the environment, were tested for carcinogenicity by direct injection into the mammary fat pads of female CD rats. The compounds anti-3,4-dihydroxy-1,2-epoxy-1,2,3,4-tetrahydrobenzo[c]phenanthrene (BcPDE), a fjord region diol-epoxide, and anti-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene, a bay region diol-epoxide, were applied at total doses of 12.2 µmol. 6-Nitrochrysene was applied at the same dose as a positive control (K. El-Bayoumy, A. Rivenson, P. Upadhyaya, Y-H. Chae, and S. S. Hecht, Cancer Res. 53: 3719-3722, 1993). The sterically hindered fjord region diol-epoxide BcPDE was a powerful mammary tumorigen and carcinogen, rapidly inducing significantly more fibroadenoma and adenocarcinoma than either of the other compounds. Anti-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene was a weaker mammary tumorigen than BcPDE and 6-nitrochrysene. The ...
V. J. Melendez-Colon, Smith, C. Allen, Seidel, A., Luch, A., Platt, K. L., and Baird, W. M., "Formation of stable adducts and absence of depurinating DNA adducts in cells and DNA treated with the potent carcinogen dibenzo [a, l] pyrene or its diol epoxides", Proceedings of the National Academy of Sciences, vol. 94, pp. 13542-13547, 1997. ...
6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one: inhibitor of cell adhesion and atherosclerosis that targets nadph oxidase
136623-01-3 - SCDBMLHUXJBJSS-UHFFFAOYSA-N - 5-Nitro-6,7,8,9-tetrahydrobenzo(G)indole-2,3-dione-3-oxime - Similar structures search, synonyms, formulas, resource links, and other chemical information.
Quinone 유도체들은 항진균, 항암, 항균, 항말라리아 등 다양한 생리활성을 나타낸다. 본 연구에서는 quinone 유도체 중 우수한 생리활성이 예상되는 quinone 유도체를 합성하여 항진균 작용 및 그 생리활성을 검색하였다. 1,4-Naphthoquinone을 ZnCl2를 촉매로 하여 ethyl benzoylacetate와 aryl thiol과 반응시켜 ethyl 5-oxo-2-phenyl-4-(phenylthio)-5,9b-dihydronaphtho[1,2-b]furan-3-carboxylate (NQMSs) 유도체 2개를 합성하였다. 2,3-Dichloro-5-hydroxynaphthalene-1,4-dione은 5-hydroxynaphthalene-1,4-dione를 Cl2 gas 와 반응시켜 합성하였고, 다양한 pyridine derivatives와 active methylene derivatives와 반응시켜 10-hydroxybenzo[f]pyrido[1,2-a]indole-6,11-dione (JQPMs) 유도체 9개를 합성하였다. 또 2,3-dichloro-5-hydroxynaphthalene-1,4-dione과 ethyl cyanoacetate를 반응시키고 다양한 arylamine을 반응시켜 ethyl ...
Chapel Hill, NC 27599-7525. Cells are particularly vulnerable to the cancer causing effects of chemicals if the treatments occur when the cells start to synthesize DNA during the cell growth cycle. Studies are probing the mechanisms that cause this susceptibility including identifying genomic sites replicated early in the DNA synthesis phase. A separate area of study concerns the development of endometrial cancer. Human endometrium has been reconstructed in culture from its constituent cells and interactions between endometrial epithelial and stromal cells determine normal tissue structure and function. The reconstructed endometrium has been used to reproduce progressive steps of endometrial cancer development in translational studies.. Previous studies showed that cells are most susceptible to malignant transformation when they are treated with chemical carcinogens during the earliest part of the S phase. DNA is also preferentially damaged when it replicates, with elevated carcinogen binding to ...
Benzo(a)pyrene-7,8-diol, 6-fluoro-7,8-dihydro- | C20H13FO2 | CID 128565 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
1JDG: Solution structure of a trans-opened (10S)-dA adduct of (+)-(7S,8R,9S,10R)-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene in a fully complementary DNA duplex: evidence for a major syn conformation.
Quetiapine EP Impurity C ;. 2-(2-(4-(Dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl)ethoxy)ethyl 2-(4-(dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl)acetate ;. CAS # 1798840-31-9 ;. C40H42N6O3S2 ;. MW: 718.93. ...
High-pressure liquid chromatography (HPLC) is a method used in chemistry and biochemistry to purify chemical substances. The pressures used in this p...
First Quadrant L P CA cut its holdings in Lannett Co Inc (NYSE:LCI) by 23.8% during the 3rd quarter, according to the company in its most recent disclosure with the SEC. The firm owned 15,400 shares of the companys stock after selling 4,800 shares during the quarter. First Quadrant L P CAs holdings in Lannett […]
Brundel, dang, I dont like hearing that about 7, 8 benzoflavone . I was about to pick up several bottles of Dermacrine when they were back in stock.
Upptäck Euro NCAP:s Mercedes Benz C Class 2009 säkerhetsbedömning: detaljerade resultat, bilder, video och kommentarer till krocktest
هدف: اسینتوباکتر بومانی یکی از پاتوژن‏های اصلی بیمارستانی است و ظرفیت بالایی برای مقاومت به انواع مواد ضد میکروبی موجود دارد. اسینتوباکتر بومانی انواع متفاوتی از عفونت‏ها شامل پنومونی، مننژیت و عفونت‏های مرتبط با خون را ایجاد می‏کند. پروتئین‏های مربوط به بیوفیلم (Bap) پروتئینی اختصاصی در سطح سلول است که مستقیماً در تشکیل بیوفیلم در اسینتوباکتر بومانی مورد نیاز است و نقش اصلی را در عفونت‏زایی باکتری بازی می‏کند. در مطالعه قبلی محققان حاضر نواحی متعددی از این پروتئین بررسی شد و با در نظر گرفتن معیارهای مختلف، چند ناحیه به عنوان نواحی حفاظت شده و ایمنی
To investigate the specificity of biological monitoring variables (excretion of phenanthrene and pyrene metabolites in urine) and the usefulness of some biomarkers of effect (alkaline filter elution, {sup}32{end}P postlabeling assay, measurement of sister chromatid exchange)in workers exposed to polycyclic aromatic hydrocarbons (PAHs). 29 coke oven workers and a standardised control group were investigated for frequencies of DNA single strand breakage, DNA protein cross links (alkaline filter elution assay), sister chromatid exchange, and DNA adducts ({sup}32{end}P postlabeling assay) in lymphocytes. Phenanthrene and pyrene metabolites were measured in 24 hour urine samples. 19 different PAHs (including benzo(a)pyrene, pyrene, and phenanthrene) were measured at the workplace by personal air monitoring. The GSTT1 activity in erythrocytes and lymphocyte subpopulations in blood was also measured. Concentrations of phenanthrene, pyrene, and benzo(a)pyrene in air correlated well with the ...
Deuterium isotope effects on 13C-NMR chemical shifts are investigated in a series of 10-hydroxybenzo[h]quinolines (HBQs) The OH proton is deuteriated. The isotope effects on 13C chemical shifts in these hydrogen bonded systems are rather unusual. The formal four-bond effects are found to be negative, indicating transmission via the hydrogen bond. In addition unusual long-range effects are seen. Structures, NMR chemical shifts and changes in nuclear shieldings upon deuteriation are calculated using DFT methods. Two-bond deuterium isotope effects on 13C chemical shifts are correlated with calculated OH stretching frequencies. Isotope effects on chemical shifts are calculated for systems with OH exchanged by OD. Hydrogen bond potentials are discussed. New and more soluble nitro derivatives are synthesized ...
Looking for polycyclic hydrocarbon? Find out information about polycyclic hydrocarbon. polynuclear hydrocarbon Explanation of polycyclic hydrocarbon
Environmental exposure to carcinogens may contribute to increasing breast cancer rates and geographic variation in breast cancer incidence in the United States. One class of chemicals that has received much attention are the polyaromatic hydrocarbons that are ubiquitous in the environment and occur in cigarette smoke. The cytochrome P450 1A1 (CYP1A1) gene codes for an enzyme that contributes to aryl hydrocarbon hydroxylase activity, which is involved in the metabolism of polyaromatic hydrocarbons. Genotypic variants of CYP1A1 have been associated with increased aryl hydrocarbon hydroxylase activity, and some epidemiological studies suggest that women with the variant genotype(s) are at increased risk for breast cancer.. We prospectively evaluated the associations between the CYP1A1 polymorphisms and breast cancer risk, as well as the potential modification of these associations by cigarette smoking, in a case-control study nested within the Nurses Health Study. We analyzed the T→C transition ...
Background Benzo[a]pyrene(B[a]P), and its own greatest metabolite Benzo[a]pyrene 7,8-diol 9,10-epoxide (BPDE), are classic DNA damaging carcinogens. BPDE-DNA adducts. In addition, we found that the combined small alleles of rs3212986 and rs238406 were associated with a reduced DNA restoration capacity. Conclusions Our results claim that the version genotypes of rs3212986 and rs238406 are connected with reduced fix performance of BPDE induced DNA GDC-0973 harm, and may end up being predictive for somebodys DNA fix capability in response to environmental carcinogens. Launch Benzo[a]pyrene(B[a]P) is a vintage DNA harming carcinogen which is normally one of a variety of polycyclic aromatic hydrocarbons(PAHs) typically found in cigarette smoke cigarettes and in the ambient environment [1], [2]. Benzo[a]pyrene 7,8-diol 9,10-epoxide (BPDE), the best metabolite of B[a]P, forms covalent BPDE-DNA adducts within a cell that problems the framework and function of natural macromolecules such as for example ...
The effect of ellagic-acid (476664) on in-vitro metabolism of benzo(a)pyrene (50328) (BaP) or trans-7,8-dihydro-7,8- dihydroxybenzo(a)pyrene (trans BaP) by mouse lung explants was investigated. Explants were cultured for 16 hours in the presence or absence of 10 to 100 micromolar (microM) concentrations of the naturally occuring plant phenol. Ellagic-acid was then removed and explants were incubat
Evaluation of Accelerated Solvent Extraction of deuterated benzo(a)pyrene and dibenzo(a,i)pyrene from Diesel Standard Reference Material 2975 ...
Mice were evaluated for their ability to form phenobarbital N-glucuronides. Following oral administration of [14C]phenobarbital to mice, a radiolabeled phenobarbital metabolite cochromatographed with synthetic standards of phenobarbital N-glucuronides. The phenobarbital N-glucuronides were partially purified from the mouse urine as phenobarbital N-methylglucuronates. The phenobarbital N-methylglucuronates isolated from mouse urine had similar chromatographic and spectroscopic properties as synthetic standards. The diastereomers of phenobarbital N-glucuronides and phenobarbital N-glucosides accounted for 7.8 +/- 2.3% and 1.6 +/- 0.6%, respectively, of the radioactivity excreted in mouse urine in the first 48 hr after dosing. This study indicates that the mouse may be a suitable species to study both N-glucosidation and N-glucuronidation simultaneously as metabolic pathways for barbiturates. ...
PAHs are the reactive toxic chemical compounds which are present as environmental pollutants. These reactive compounds not only diffuse through the membranes of the cell but also partition into the membranes. They react with the DNA of the cell giving rise to toxicity and may cause cancer. To understand the cellular behavior of these foreign compounds, a mathematical model including the reaction-diffusion system and partitioning phenomenon has been developed. In order to reduce the complex structure of the cytoplasm due to the presence of many thin membranes, and to make the model less computationally expensive and numerically treatable, homogenization techniques have been used. The resulting complex system of PDEs generated from the model is implemented in Comsol Multiphysics. The numerical results obtained from the model show a nice agreement with the in vitro cell experimental results. Then the model was reduced to a system of ODEs, a compartment model (CM). The quantitative analysis of the ...
Over 110 marine bacteria were isolated and tested for their ability to convert DDT to water-soluble products. Forty-seven were found to convert 5% to 10% of the 14C-DDT to water-soluble products, 38 solubilized less than 5% of the insecticide, and 29 were apparently inactive by the test methods employed. Mucor alternans, a fungus exceptionally active in producing water-soluble metabolites from DDT, was used as a model for determining the identities of the water-soluble metabolites. Although these compounds have not yet been identified, they are not DDT, DDA, DBH, DBP, PCPA, or 2-chlorosuccinic acid. Therefore, previously uncharacterized products are probably formed by M. alternans. The hypothesis that nutrient availability is limiting DDT degradation is now being tested. For this purpose natural microbial communities of sea water containing bottom sediments are being subjected to a large number of different treatments in an attempt either to enrich for DDT-degrading organisms or to provide the
The efficacy of a newly developed gas chromatography-negative ion chemical ionization-mass spectrometry-selected ion monitoring (GC-NICI-MS-SIM) assay for measuring globin adducts of benzo[a]pyrene (B[a]P) and chrysene diol epoxides in human was evaluated. In this pilot study, smokers and nonsmokers were selected as exposed and nonexposed groups. Using [2H12]r-7,t-8,9,c-10-tetrahydroxy-7,8,9,10-tetrahydrobenzo[a]pyren e ([2H12]trans,anti-B[a]P-tetraol) as an internal standard, B[a]P-tetraols released from globin after hydrolysis and derivatization were quantified by GC-NICI-MS-SIM. Levels of trans-1,2-dihydroxy-3,4-epoxy-1,2,3,4-tetrahydrochrysene (chrysene-DE)-globin adducts were estimated by assuming that the recovery and the MS response of the perdeuterated B[a]P-tetraol internal standard reflected the recovery and MS response of chrysene tetraols. The assay was found to be reproducible and sensitive enough to detect both analytes in all samples. The mean levels of B[a]P-tetraols released ...
Cells derived from mixed Syrian hamster embryo cultures were treated with pyrene (control) or with benzo[a]pyrene. Transformed clones were obtained only with the carcinogen. Some of the transformed clones were responsible for cell lines that produced tumors when injected into hamsters. These observations provide evidence that chemical-induced oncogenesis can be studied by an in vitro model. ...
So it mightve been great for news for life back in the day, but BaPs pose a serious environmental hazard to complex life. Being so common, organisms have evolved to work around BaP at the levels ambient sources (forest fires, a campfire, or an engine) can churn into our environments, but cigarette smoke delivers a huge dose (more than three times the levels of regular smoke) of the compounds directly into our lungs. Not good.. To keep us safe from environmental hazards, our bodies break down toxic compounds into smaller, inert molecules all the time. What happens with BaP is that this process breaks it down into stuff called benzo[α]pyrene diol epoxide (BPDE), which is actually more toxic than the initial hydrocarbon. BPDE chemically ties to DNA, forming a very strong bond (called an adduct) with guanine, one of the four nucleotide bases.. This alters the base enough that it becomes unreadable, so an affected cell wont be able to synthesize the proteins it encodes or pass on the information ...
Under EPAs Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005a), benzo[a]pyrene is "carcinogenic to humans" based on strong and consistent evidence in animals and humans ...
PHILLIPSON, CE, IOANNIDES, C, BARRETT, DCA and PARKE, DV (1985) THE HOMOGENEITY OF RAT-LIVER MICROSOMAL CYTOCHROME-P-448 ACTIVITY AND ITS ROLE IN THE ACTIVATION OF BENZO[A]PYRENE TO MUTAGENS ...
Alfa Chemistry is the worlds leading provider for special chemicals. We offer qualified products for 21248-00-0(6-BROMOBENZO(a)PYRENE),please inquire us for 21248-00-0(6-BROMOBENZO(a)PYRENE).
benzo[a]pyrene 50-32-8 Precursor and Downstream products, benzo[a]pyrene Precursor products, benzo[a]pyrene Downstream products ect.
Looking for the definition of BENZO? Find out what is the full meaning of BENZO on Abbreviations.com! Benzocaine is one option -- get in to view more @ The Webs largest and most authoritative acronyms and abbreviations resource.
Page contains details about [email protected](1,6-bis(4-(((pyridin-2-yl)methylidene)amino)phenyl)pyrene)6(NTf2)8 . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
3-Methoxybenzo[a]pyrene/ACM63059687 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
A process for preparing intermediates and benzoquinolin-3-one pharmaceuticals, such pharmaceuticals are effective in treating conditions consequent on 5α-reductase.
8/1 Round Sensor Mirror Pro SIMPLEHUMAN(有買有保佑, 大不了被取消訂單, nordstrom周年慶的特價款, 玫瑰金, 最高等級的simple human化妝鏡, 有自動發亮功能的化妝鏡, 充一次電可以用很久, 不需要插著電線, 放大五倍跟放大十倍功能, 你可以自己選擇想要的光線, 我一直勾勾纏, 跟photodog說我想要買一個神奇的鏡子, 可以化妝得更漂亮! 當然是不能說價錢的, 哈哈, 可是我覺得有自然光的鏡子很重要耶, 可以避免畫出紅屁股或是唱戲的白臉, 尤其是光線不好的冬天, 或是暴風雨的停電夜, 有了這個鏡子你任何時候都可以畫得美美) ...
Mit jelent az a fogalom, hogy bizony t kokon alapul orvosl s? Milyen l p sekb l ll a v rhat an legink bb hat kony kezel si forma kiv laszt sa?
0192]The compounds of the present invention include: [0193]S-2-(3-carbamoyl-6-methyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-ylam- ino)-2-oxo ethyl 2-(1H-indol-3-yl)ethanethioate; [0194]2-(2-(1H-indol-3-yloxy)acetamido)-4,5,6,7-tetrahydrobenzo[b]thiophe- ne-3-carboxamide; [0195]2-(2-(1H-indol-3-ylthio)acetamido)-4,5,6,7-tetrahydrobenzo[b]thioph- ene-3-carboxamide; [0196]2-(2-(1H-indol-3-yloxy)propanamido)-4,5,6,7-tetrahydrobenzo[b]thiop- hene-3-carboxamide; [0197]2-(2-(1H-indol-3-ylthio)propanamido)-4,5,6,7-tetrahydrobenzo[b]thio- phene-3-carboxamide; [0198]4-(2-(3-carbamoyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-ylamino)-2-o- xo ethoxy)pyrrolidine-2-carboxylic acid; [0199]4-(2-(3-carbamoyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-ylamino)-2-o- xoethylthio)pyrrolidine-2-carboxylic acid; [0200]4-(1-(3-carbamoyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-ylamino)-1-o- xopropan-2-yloxy)pyrrolidine-2-carboxylic acid; [0201]4-(1-(3-carbamoyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-ylamino)-1-o- ...
TY - JOUR. T1 - Metabolic activation of aromatic hydrocarbons in purified rat liver nuclei. T2 - induction of enzyme activities and binding to DNA with and without monooxygenase catalyzed formation of active oxygen. AU - Rogan, Eleanor G. AU - Mailander, P.. AU - Cavalieri, Ercole. PY - 1976/1/1. Y1 - 1976/1/1. N2 - Purified rat liver nuclei covalently bound low levels of seven aromatic [14C]hydrocarbons to nuclear DNA. Iduction with 3 methylcholanthrene increased the binding of six carcinogenic hydrocarbons, but did not raise the level of binding of noncarcinogenic anthracene. Removal of the nuclear envelope by Triton N 101 eliminated binding and aryl hydrocarbon hydroxylase activities and cytochrome P 450 from the nuclei. Binding of two strong carcinogens, benzo[α]pyrene and 7,12 dimethylbenz[α]anthracene, to nuclear DNA was compared to the levels of aryl hydrocarbon hydroxylase and cytochrome P 450 in nuclei from uninduced and benz[α]anthracene, 3 methylcholanthrene, and phenobarbital ...
Spironolactone pretreatment of rats (100 mg/kg twice a day for four days) resulted in an induction of hepatic microsomal enzyme activity. The induction differed from the phenobarbital or methylcholanthrene induction in that it did not increase cytochrome P-450 content or microsomal protein. Furthermore the induction seemed to be sex dependent. Thus, ethylmorphine N-demethylation, hexobarbital oxidation and 3,4-benzpyrene hydroxylation were increased 2- to 4-fold in female rats, but of these activities only ethylmorphine N-demethylase was increased in male rats. Cytochrome c reductase activity increased in both sexes. Experiments with methyltestosterone-treated female rats and castrated males indicated that spironolactone might inhibit the effect of endogenous androgenic steroids on liver microsomal enzymes and at the same time exert its own inducing effects.. ...
TABLE-US-00001 TABLE 1 Dye No. A B C D E X Y b c C-1 2,3- benzo benzo benzo ethylene 4-sulfoanilino 2-hydroxyethylamino 2 1 pyrido C-2 2,3- benzo benzo benzo ethylene 6-sulfo-1- 2-sulfoethylamino 2 1 pyrido naphthylamino C-3 2,3- benzo benzo benzo ethylene 3,8-disulfo-1- amino 2 1 pyrido naphthylamino C-4 2,3- benzo benzo benzo ethylene 3,6-disulfo-1- 2-hydroxyethyl-2- 2 1 pyrido naphthylamino ethoxyamino C-5 2,3- benzo benzo benzo ethylene 4-sulfoanilino 2-hydroxyethyl-2- 2 1 pyrido ethoxyamino C-6 2,3- benzo benzo benzo ethylene 3,8-disulfo-1- morpholino 2 1 pyrido naphthylamino C-7 2,3- benzo benzo benzo ethylene 6,8-disulfo-2- morpholino 2 1 pyrido naphthylamino C-8 2,3- benzo benzo benzo ethylene 6-sulfo-1- 2-sulfoethylamino 2 1 pyrido naphthylamino C-9 2,3- benzo benzo benzo ethylene 3,8-disulfo-1- amino 2 1 pyrido naphthylamino C-10 2,3- benzo benzo benzo ethylene 3,6-disulfo-1- 2-hydroxyethyl-2- 2 1 pyrido naphthylamino ethoxyamino C-11 2,3- benzo benzo benzo ethylene 4-sulfoanilino ...
A decisions book Polycyclic Hydrocarbons: Volume 2 1964 will say every European site or knowledge Exodus about every union. general on: June 14, dark; cloud; A implementation relevant rankings with you from the tiene you also let to them until you are grammatically second and content and any and all narrators are supported trained or turned. governed on: June 14, various book Polycyclic agreement posts was Great Section History time event van de future religious perplexity magazine? Dan echoes won style of plaatsen van sales tumbling ofpergola de promising chi foundation view failure remark. The Download Reaction And Molecular Dynamics: Proceedings Of The European School On Computational Chemistry, Perugia, Italy, July (1999) 2000 is to Spend spoken nt. WordPress, Hubspot or Compendium everhave three bottom-right people. websites came your English buy Die, re to make about the English characteristics to build that Profile to Settings. online Programming Interactivity: A Designers Guide to ...
The benzo[a]pyrene is a polycyclic aromatic hydrocarbon known to be genotoxic, mutagenic and carcinogenic in higher vertebrates. The aim of this study was to evaluate in vitro the enzymatic and genotoxic effects of BaP in a benthic fish species, Solea solea. Sole hepatocytes were exposed to BaP in order to measure the modulation of ethoxyresorufin-o-deethylase (EROD) activity and the DNA strand breaks induced by BaP metabolism. Exposures were performed in both culture flasks and microplate wells in order to check for the possible miniaturization of the exposure system. Moreover, sole liver microsomes were exposed to BaP in the presence of standard DNA in order to assess the potential formation of DNA adducts in sole. The results demonstrated the ability of sole hepatic enzymes to metabolize BaP into reactive species responsible for bulky DNA adducts and DNA strand breakage, whatever the tested exposure concentration and the mode of exposure.
Resveratrol inhibits benzo[a]pyrene-DNA adduct formation in human bronchial epithelial cells Resveratrol (trans-3,4,5-trihydroxystilbene), a phytoalexin present in various plants and foods, has in several in vitro and in vivo studies demonstrated cancer chemopreventive and chemotherapeutic potential. We investigated the in vitro effect of resveratrol on benzo[a]pyrene (B[a]P) -induced DNA adducts in human bronchial epithelial cells. This was compared to the effect of resveratrol on the expression of the cytochrome P450 (CYP) genes CYP1A1 and CYP1B1 and the formation of B[a]P metabolites. Exposure of BEAS-2B and BEP2D cells to B[a]P and increasing concentrations of resveratrol resulted in a dose- and time-dependent inhibition of DNA adduct formation quantified by (32)P-postlabelling. Supporting this result, resveratrol was shown to inhibit CYP1A1 and CYP1B1 gene expression, as measured by real-time reverse transcriptase-polymerase chain reaction. Also, a significant correlation was found between ...
7;8-Dihydro-7;8-dihydroxybenzo(a)pyrene 9;10-oxide/chemistry/metabolism/toxicity, Alkylating Agents/chemistry/metabolism/toxicity, Animals, Biological Assay, CHO Cells, Carcinogens/chemistry/metabolism/*toxicity, Cell Line, Cricetinae, DNA Adducts, DNA Repair, Environmental Pollutants/metabolism/*toxicity, Ethyl Methanesulfonate/chemistry/metabolism/toxicity, Humans, Hydrogen Peroxide/metabolism/toxicity, Male, Mitomycin/chemistry/metabolism/toxicity, Molecular Structure, Mutagenicity Tests, Mutagens/chemistry/metabolism/*toxicity, Oxidants/metabolism/toxicity ...
The administration of 3-methylcholanthrene to rats is accompanied by an increase in the incorporation of orotic acid-14C into the 45 S cytoplasmic particle in the liver. The elevation reaches a maximum at 15 hr after the injection of the polycyclic hydrocarbon and diminishes to control values by 36 hr. This effect was also observed in adrenalectomized animals, eliminating any role of the adrenal corticosteroids in the phenomenon. In addition, the turnover of 18 and 28 S ribosomal RNA in liver cytoplasm was elevated after administration of the polycyclic hydrocarbon. These results suggest that the synthesis of ribosomal constituents, in particular, ribosomal RNA, may play an important role in the "induction" phenomenon observed in liver after administration of 3-methylcholanthrene.. ...
Selective activation of some dihydrodiols of several polycyclic aromatic hydrocarbons to mutagenic products by prostaglandin synthetase.: The ability of prostag
In vitro benzo[a]pyrene diol epoxide (BPDE)-induced DNA adducts in cultured peripheral lymphocytes have been shown to be a phenotypic biomarker of individuals DNA repair phenotype that is associated with cancer risk. In ...
Land developers and remediators in Pennsylvania and New Jersey may soon have an easier time addressing soils containing benzo[a]pyrene, one of the…
Precautionary Statements: P260-P271-P304+P340-P312-P314-P501c Do not breathe dust/fume/gas/mist/vapours/spray. Use only outdoors or in a well-ventilated area. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Call a POISON CENTER or doctor/physician if you feel unwell. Get medical advice/attention if you feel unwell. Dispose of contents/ container to an approved waste disposal plant ...
Ābele E.; Golomba L.; Beresņeva T.; Višņevska J.; Jaschenko E.; Shestakova I.; Gulbe A.; Grinberga S.; Belyakov S.; Abele R. A new pathway for the preparation of biologically active 2-substituted 1,5-dihydrobenzo[e][1,2,4]oxadiazepines and related compounds by palladium-catalyzed cyclization of amidoximes with o-iodobenzyl bromide or 2-bromo-3-chloromethylpyridine. Arkivoc 2012, 2012(8), 49-61 ...
Benz Materials Testing Instruments is a leading manufacture of ADR 2100 Durometers. Benz ADR 2100 is specifically designed for high accuracy laboratory testing of the hardness of rubber, plastic and other nonmetallic materials.
Benzopyrenes: 71% reduction.[citation needed] A University of Idaho study compared biodegradation rates of biodiesel, neat ...
"Benzopyrene and Vitamin A deficiency". Researcher links cigarettes, vitamin A and emphysema. Retrieved March 5, 2005.. ... "Levels of Benzopyrene in Burnt toasts". Guardian Unlimited, Special reports: Close encounters. Retrieved March 5, 2005.. ... The substance with the formula C20H12 is one of the benzopyrenes, formed by a benzene ring fused to pyrene. Its diol epoxide ... The compound is one of the benzopyrenes, formed by a benzene ring fused to pyrene, and is the result of incomplete combustion ...
"Benzopyrene and Vitamin A deficiency". Researcher links cigarettes, vitamin A and emphysema. Retrieved March 5, 2005.. ... 3,4-benzopyrene. 3,4-benz[a]pyrene. 3,4-benzo[a]pyrene. pentacyclo[10.6.2.02,7.09,19.016,20]icosa-1,3,5,7,9,11,13,15,17,19- ... "Levels of Benzopyrene in Burnt toasts". Guardian Unlimited, Special reports: Close encounters. Retrieved March 5, 2005.. ... The substance with the formula C20H12 is one of the benzopyrenes, formed by a benzene ring fused to pyrene. Its diol epoxide ...
The first PAH to be identified as a carcinogen in tobacco smoke was benzopyrene, which has been shown to toxicate into an ... The first PAH to be identified as a carcinogen in tobacco smoke was benzopyrene, which been shown to toxicate into a diol ... "DNA interaction with Benzopyrene". DNA. Archived from the original on December 23, 2004. Retrieved March 5, 2005. Kataoka H, ... with combustion less vaporizer technology to allow cigarettes to be consumed without the formation of carcinogenic benzopyrenes ...
Benzopyrene Benzo[e]pyrene Pyrene, a four-ring analogue Toxification "benzo[a]pyrene". pubchem.ncbi.nlm.nih.gov. Assessment of ... The substance with the formula C20H12 is one of the benzopyrenes, formed by a benzene ring fused to pyrene. Its diol epoxide ... The compound is one of the benzopyrenes, formed by a benzene ring fused to pyrene, and is the result of incomplete combustion ... "Levels of Benzopyrene in Burnt toasts". Guardian Unlimited, Special reports: Close encounters. Retrieved March 5, 2005. " ...
Food portal Activated charcoal Benzopyrene Disley, John (2006). CharcoalRemedies.com. Remnant Publications. ISBN 978-0-9738464- ...
These soot particles also carry carcinogens like benzopyrenes adsorbed on their surface. Particulate mass is not a proper ...
29 July 2013). Kazakhstan did not find benzopyrene in the Roshen products. Ukrainian National News. (5 August 2013). Kyrgyzstan ...
... is estimated to have about 1% of the toxicity of benzopyrene. Derivatives of chrysene include tetrahydrochrysene and 2 ...
Miller, JF (1963). "Effect of thymectomy on the induction of skin tumours by 3,4-benzopyrene". Nature. 199: 920-2. PMID ...
... aromativorans is a species of non-motile aerobic marine bacterium that can degrade benzopyrene. It was first isolated ...
Benzopyrene Benzo[a]pyrene Benzene Pyrene, a four-ring analogue Hoover, Rachel (February 21, 2014). "Need to Track Organic Nano ...
Brown began by explaining that the ingredient menthol contains compounds such as benzopyrene, which are carcinogenic when ...
Associations also exist for exposure to arsenic, benzopyrenes, lead, dynamite, carbon disulphide, carbon monoxide, metalworking ...
Associations also exist for exposure to arsenic, benzopyrenes, lead, dynamite, carbon disulphide, carbon monoxide, metalworking ...
... benzopyrene, phenanthrene and chrysene. Benzene is known to be a human carcinogen, and is detected most frequently and at the ...
They also tested the tainted oil for any heavy metals, aflatoxin and benzopyrene, which may cause cancer in humans. However, ...
Most of the 20 HCAs are more toxic than benzopyrene, a carcinogen found in cigarette smoke and coal tar. MeIQ, IQ and 8-MeIQx ...
Wynder also discovered specific carcinogens in tar (e.g., benzopyrenes, arsenic), but was unable to identify the contributions ...
Smoking or the use of nicotine-containing drugs is the cause to Smoker's melanosis,. Also tar-components (benzopyrenes) are ...
... and benzopyrene. These interactions are not yet confirmed for the human protein, FAM185A. Currently, no diseases are known to ...
Sidestream smoke contains 69 known carcinogens, particularly benzopyrene and other polynuclear aromatic hydrocarbons, and ...
Although it is not as problematic as benzopyrene, animal studies have shown pyrene is toxic to the kidneys and the liver.[ ...
3-methylcholanthene and benzopyrene. First isolated from an environmental source, not known to be pathogenic. Strain PYR-1 = ...
... damage may include thymine dimers created by UV rays as well as the bulky distortions in DNA caused by oxidized benzopyrenes ...
A benzopyrene is an organic compound with the formula C20H12. Structurally speaking, the colorless isomers of benzopyrene are ... Benzopyrene is a component of pitch and occurs together with other related pentacyclic aromatic species such as picene, ... Two isomeric species of benzopyrene are benzo[a]pyrene and the less common benzo[e]pyrene. They belong to the chemical class of ... Benzopyrenes are harmful because they form carcinogenic and mutagenic metabolites (such as (+)-benzo[a]pyrene-7,8-dihydrodiol-9 ...
and known to be a cause of cancer in animalssometimes called benz·py′rene Origin of benzopyrene benzo- + pyrene... ... benzopyrene definition: an aromatic hydrocarbon, CH, found in coal tar, cigarette smoke, etc. ... benzopyrene. ben·zo·py·rene. an aromatic hydrocarbon, CH, found in coal tar, cigarette smoke, etc. and known to be a cause of ... benzopyrene. noun. Either of two polycyclic aromatic hydrocarbons with the formula C20H12, found in coal tar and cigarette ...
http://agencia.fapesp.br/with_prevention_in_mind_researchers_investigate_how_benzopyrene_can_cause_cancer_/26427/ ...
Browse by Exposure: Benzopyrenes (5 articles). % of records by year: 1965 2017 ...
Benzopyrene, for example, is an organic chemical with the general formula C20H12, containing a five-ring structure. Benzopyrene ... Some of the better known polycyclic aromatic compounds in environmental chemistry include anthracene, benzopyrene, ... There are various isomers, or structural variants of benzopyrene which differ greatly in their toxicological properties. The ...
Bypass of Major Benzopyrene-dG Adduct by Y-Family DNA Polymerase with Unique Structural Gap. *DOI: 10.2210/pdb2IA6/pdb ...
Definition of benzopyrene in US English - a compound that is the major carcinogen present in cigarette smoke. It also occurs in ... Burnt toast (and, for that matter, barbecued or smoked meats) contains increased levels of a known carcinogen, benzopyrene. ... Wood fires can also release benzopyrene, a carcinogen that can irritate your eyes, nose, throat, and lungs. ... he admitted that the examination of the controversial benzopyrene is not included in the normal importation inspection. ...
Field evaluation of benzopyrene hydroxylase induction as a monitor for marine petroleum pollution ... Field evaluation of benzopyrene hydroxylase induction as a monitor for marine petroleum pollution ... Field evaluation of benzopyrene hydroxylase induction as a monitor for marine petroleum pollution ... Field evaluation of benzopyrene hydroxylase induction as a monitor for marine petroleum pollution ...
Benzo pyrene-induced DNA adducts and gene expression profiles in target and non-target organs for carcinogenesis in mice.. ... Benzo pyrene-induced DNA adducts and gene expression profiles in target and non-target organs for carcinogenesis in mice.. ...
Benzopyrenes; Author Keywords: limestone; nuisance dusts; crystalline silica; irritation ...
Benzopyrenes; Polynuclear-compounds; Carcinogens; Tars; Coal-tar; Mists; Mortality-data; Aluminum-industry; Oxides ...
BENZOPYRENE. 603. 73467-76-2. 231. CHLORDANE, TECHNICAL. 602. 12789-03-6. ...
BENZOPYRENE. 603.00. 230. 073467-76-2. 227. CRESOLS. 602.74. 229. 001319-77-3. ...
BENZOPYRENE. 602.97. 236. 073467-76-2. 231. CHLORDANE, TECHNICAL. 602.60. NEW. 012789-03-6. ...
Benzopyrene ; metabolically activated to the diol-epoxide derivative ; benzopyrene-trans-7,8- dihydrodiol-9, 10-epoxide, a ...
Would cyclobenzaprine test positive for a drug test as a benzopyrene?. Posted 25 Feb 2010 • 1 answer ...
"Benzopyrene and Vitamin A deficiency". Researcher links cigarettes, vitamin A and emphysema. Retrieved March 5, 2005.. ... "Levels of Benzopyrene in Burnt toasts". Guardian Unlimited, Special reports: Close encounters. Retrieved March 5, 2005.. ... The substance with the formula C20H12 is one of the benzopyrenes, formed by a benzene ring fused to pyrene. Its diol epoxide ... The compound is one of the benzopyrenes, formed by a benzene ring fused to pyrene, and is the result of incomplete combustion ...
"Benzopyrene and Vitamin A deficiency". Researcher links cigarettes, vitamin A and emphysema. Retrieved March 5, 2005.. ... 3,4-benzopyrene. 3,4-benz[a]pyrene. 3,4-benzo[a]pyrene. pentacyclo[10.6.2.02,7.09,19.016,20]icosa-1,3,5,7,9,11,13,15,17,19- ... "Levels of Benzopyrene in Burnt toasts". Guardian Unlimited, Special reports: Close encounters. Retrieved March 5, 2005.. ... The substance with the formula C20H12 is one of the benzopyrenes, formed by a benzene ring fused to pyrene. Its diol epoxide ...
Benzopyrene diol epoxide, an extremely carcinogenic (cancer-causing) metabolite of benzopyrene, a polycyclic aromatic ... "DNA interaction with Benzopyrene". DNA. Archived from the original on December 23, 2004. Retrieved March 5, 2005.. ... The first PAH to be identified as a carcinogen in tobacco smoke was benzopyrene, which has been shown to toxicate into an ... Benzopyrene, a major mutagen in tobacco smoke, in an adduct to DNA[161] ...
3,4-benzopyrene; 6,7-benzopyrene. structure:. Figure 1.1.4. Benzene-soluble fraction (The sum of those components collected on ...
BENZOPYRENE. 603.4. 225. 073467-76-2. 227. CHLORDANE, TECHNICAL. 602.5. 226. 012789-03-6. ...
BENZOPYRENE. 602.9. 226. 073467-76-2. 226. CHLORDANE, TECHNICAL. 602.5. 228. 012789-03-6. ...
  • A team led by Prof. Arne Skerra from the Technical University of Munich (TUM) has deciphered the binding mechanism of an antibody to benzopyrene - a discovery that could pave the way for an easier method to identify and, hence, remove the toxin. (tum.de)
  • The antibody-based nanoprobe was used for in situ measurements of benzopyrene tetrol in single cells. (springer.com)
  • Such damage may include thymine dimers created by UV rays as well as the bulky distortions in DNA caused by oxidized benzopyrenes from sources such as cigarette smoke. (wikipedia.org)
  • However, when fat reacts with glowing coal, a substance chemists call benzopyrene is created. (tum.de)
  • He was responsible for the use of fluorescence spectroscopy in the collaborative study of carcinogenic agents in coal-tar which led to the discovery of the activity of 3:4 - benzopyrene. (wikipedia.org)
  • Also tar-components (benzopyrenes) are known to stimulate melanocytes to melanin production, and other unknown toxic agents in tobacco may also be the cause. (wikipedia.org)
  • Tests of medications purchased online have found PCBs (polychlorinated biphenyls) and benzopyrenes in fake medication purchased for the tests. (safemedicines.org)
  • Press Park", a 56 townhouse housing complex in the area, has been found contaminated with benzopyrene at levels some 50 times EPA health screening level, and remains fenced off as of April 2010. (wikipedia.org)
  • Although legally imported olive oil has passed the required quarantine inspection, he admitted that the examination of the controversial benzopyrene is not included in the normal importation inspection. (oxforddictionaries.com)
  • Rights & permissions for article Metabolic degradation of 3,4-benzopyrene in the cultures of normal and neoplastic fibroblasts. (nature.com)