AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureInformation ScienceHealth Care
BenzopyrenesPolycyclic Hydrocarbons, AromaticPolycyclic CompoundsOccupational ExposureGasolinePyrenesHydrocarbonsBenzo(a)pyrenePregnancyPregnancy ComplicationsPregnancy OutcomeMultilingualismPregnancy, AnimalSmokingLanguageAmitriptylineMuscle Relaxants, CentralSubstance Abuse DetectionHair PreparationsMethenoloneEncyclopedias as TopicInternational AgenciesCarcinogens, EnvironmentalLegislation, DrugCarcinogensChrysenesHydrocarbons, AromaticPhenanthrenesIrisUnited States Environmental Protection Agency7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxideErythrocytesAnemiaMicronucleus Testso-ChlorobenzylidenemalonitrileErythrocyte MembraneMicronuclei, Chromosome-DefectiveAntimutagenic AgentsOzoneFellowships and ScholarshipsBreakfastOxidants, PhotochemicalExhibits as TopicSmoke-Free PolicyPolicy
Benzopyrenes
A class of chemicals that contain an anthracene ring with a naphthalene ring attached to it.
Polycyclic Hydrocarbons, Aromatic
A major group of unsaturated cyclic hydrocarbons containing two or more rings. The vast number of compounds of this important group, derived chiefly from petroleum and coal tar, are rather highly reactive and chemically versatile. The name is due to the strong and not unpleasant odor characteristic of most substances of this nature. (From Hawley's Condensed Chemical Dictionary, 12th ed, p96)
Polycyclic Compounds
Compounds consisting of two or more fused ring structures.
Occupational Exposure
The exposure to potentially harmful chemical, physical, or biological agents that occurs as a result of one's occupation.
Gasoline
Volative flammable fuel (liquid hydrocarbons) derived from crude petroleum by processes such as distillation reforming, polymerization, etc.
Pyrenes
A group of condensed ring hydrocarbons.
Hydrocarbons
Benzo(a)pyrene
A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Pregnancy Complications
Conditions or pathological processes associated with pregnancy. They can occur during or after pregnancy, and range from minor discomforts to serious diseases that require medical interventions. They include diseases in pregnant females, and pregnancies in females with diseases.
Pregnancy Outcome
Results of conception and ensuing pregnancy, including LIVE BIRTH; STILLBIRTH; SPONTANEOUS ABORTION; INDUCED ABORTION. The outcome may follow natural or artificial insemination or any of the various ASSISTED REPRODUCTIVE TECHNIQUES, such as EMBRYO TRANSFER or FERTILIZATION IN VITRO.
Multilingualism
The ability to speak, read, or write several languages or many languages with some facility. Bilingualism is the most common form. (From Random House Unabridged Dictionary, 2d ed)
Pregnancy, Animal
The process of bearing developing young (EMBRYOS or FETUSES) in utero in non-human mammals, beginning from FERTILIZATION to BIRTH.
Smoking
Inhaling and exhaling the smoke of burning TOBACCO.
Language
A verbal or nonverbal means of communicating ideas or feelings.
Amitriptyline
Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
Muscle Relaxants, Central
A heterogeneous group of drugs used to produce muscle relaxation, excepting the neuromuscular blocking agents. They have their primary clinical and therapeutic uses in the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. They have been used also for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in MULTIPLE SCLEROSIS. (From Smith and Reynard, Textbook of Pharmacology, 1991, p358)
Substance Abuse Detection
Detection of drugs that have been abused, overused, or misused, including legal and illegal drugs. Urine screening is the usual method of detection.
Hair Preparations
Hair grooming, cleansing and modifying products meant for topical application to hair, usually human. They include sprays, bleaches, dyes, conditioners, rinses, shampoos, nutrient lotions, etc.
Methenolone
A synthetic steroid that has been used for its anabolic action.
Encyclopedias as Topic
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
International Agencies
International organizations which provide health-related or other cooperative services.
Carcinogens, Environmental
Carcinogenic substances that are found in the environment.
Legislation, Drug
Laws concerned with manufacturing, dispensing, and marketing of drugs.
Carcinogens
Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.
Chrysenes
1,2-Benzphenanthrenes. POLYCYCLIC COMPOUNDS obtained from coal tar.
Hydrocarbons, Aromatic
Organic compounds containing carbon and hydrogen in the form of an unsaturated, usually hexagonal ring structure. The compounds can be single ring, or double, triple, or multiple fused rings.
Phenanthrenes
Iris
The most anterior portion of the uveal layer, separating the anterior chamber from the posterior. It consists of two layers - the stroma and the pigmented epithelium. Color of the iris depends on the amount of melanin in the stroma on reflection from the pigmented epithelium.
United States Environmental Protection Agency
An agency in the Executive Branch of the Federal Government. It was created as an independent regulatory agency responsible for the implementation of federal laws designed to protect the environment. Its mission is to protect human health and the ENVIRONMENT.
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
7,8,8a,9a-Tetrahydrobenzo(10,11)chryseno (3,4-b)oxirene-7,8-diol. A benzopyrene derivative with carcinogenic and mutagenic activity.
Erythrocytes
Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.
Anemia
A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.
Micronucleus Tests
Induction and quantitative measurement of chromosomal damage leading to the formation of micronuclei (MICRONUCLEI, CHROMOSOME-DEFECTIVE) in cells which have been exposed to genotoxic agents or IONIZING RADIATION.
o-Chlorobenzylidenemalonitrile
A riot control agent which causes temporary irritation of the eyes and the mucosal surface of the respiratory tract. It is a more potent irritant than OMEGA-CHLOROACETOPHENONE, but less incapacitating.
Erythrocyte Membrane
The semi-permeable outer structure of a red blood cell. It is known as a red cell 'ghost' after HEMOLYSIS.
Micronuclei, Chromosome-Defective
Defective nuclei produced during the TELOPHASE of MITOSIS or MEIOSIS by lagging CHROMOSOMES or chromosome fragments derived from spontaneous or experimentally induced chromosomal structural changes.
Antimutagenic Agents
Agents that reduce the frequency or rate of spontaneous or induced mutations independently of the mechanism involved.
Ozone
The unstable triatomic form of oxygen, O3. It is a powerful oxidant that is produced for various chemical and industrial uses. Its production is also catalyzed in the ATMOSPHERE by ULTRAVIOLET RAY irradiation of oxygen or other ozone precursors such as VOLATILE ORGANIC COMPOUNDS and NITROGEN OXIDES. About 90% of the ozone in the atmosphere exists in the stratosphere (STRATOSPHERIC OZONE).
Fellowships and Scholarships
Stipends or grants-in-aid granted by foundations or institutions to individuals for study.
Breakfast
The first meal of the day.
Oxidants, Photochemical
Compounds that accept electrons in an oxidation-reduction reaction. The reaction is induced by or accelerated by exposure to electromagnetic radiation in the spectrum of visible or ultraviolet light.
Exhibits as Topic
Discussions, descriptions or catalogs of public displays or items representative of a given subject.
Smoke-Free Policy
Prohibition against tobacco smoking in specific areas to control TOBACCO SMOKE POLLUTION.
Policy
A course or method of action selected to guide and determine present and future decisions.

The direct spectrophotometric observation of benzo(a)pyrene phenol formation by liver microsomes. (1/611)

Optical spectral repetitive scan analysis during the oxidative metabolism of benzo(a)pyrene by liver microsomal suspensions reveals the time-dependent formation of an intermediate(s) of which the visible spectra resemble those of several benzo(a)pyrene phenols. Liver microsomes from 3-methylcholanthrene-treated rats showed a greater rate of formation of the phenols than did microsomes from control animals; the rate of formation catalyzed by liver microsomes from phenobarbital-pretreated rats was intermediate. When 3-hydroxybenzo(a)pyrene was used as a standard for comparison of activity, the rates of formation of phenols were compared when measured by fluorometric, spectrophotometric, or high-pressure liquid chromatographic analytical techniques. An epoxide hydrase inhibitor, 1,1,1-trichloropropene-2,3-oxide, enhanced phenol formation regardless of the source of liver microsomes, and 7,8-benzoflavone inhibited control and 3-methylcholanthrene-induced microsomal metabolism of benzo(a)pyrene, 7,8-Benzoflavone did not effect benzo(a)pyrene metabolism by liver microsomes from phenobarbital-pretreated rats. The effect of inhibitors on the spectrophotometric assay correlates well with the results obtained from benzo(a)pyrene metabolite analysis using high-pressure liquid chromatography.  (+info)

Differences in benzo(a)pyrene metabolism between rodent liver microsomes and embryonic cells. (2/611)

Differences in benzo(a)pyrene metabolite pattern have been shown by rodent liver microsomes (Sprague-Dawley) and rodent embryo cells from Syrian hamsters and NIH Swiss mice. Rodent liver induced by methylcholanthrene shows marked quantitative variation between species. Additional pattern changes were found in mouse and hamster embryo secondary cultures with a reduction of the K-region metabolites and a marked increase in 9-hydroxybenzo(a)-pyrene. These results are indicative of a region-specific attack on the carcinogen by the cell monooxygenases which is distinct from the liver attack of microsomal enzymes on benzo(a)pyrene. These results suggest that activation and detoxification of benzo(a)pyrene may be species and tissue variable, and susceptibility and resistence to malignant transformation may be predicted on induction of a fortuitous combination of intermediate metabolic steps.  (+info)

Formation in isolated rat liver microsomes and nuclei of benzo(a)pyrene metabolites that bind to DNA. (3/611)

The hepatic nuclear fraction isolated from 3-methylcholanthrene (MC)-treated rats contained enhanced levels of cytochrome P-450 and aryl hydrocarbon hydroxylase [benzo(a)pyrene (BP) monooxygenase], whereas the activities of epoxide hydrase and reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase and the concentration of cytochrome b5 were not altered. The metabolite pattern of BP was investigated by using high-pressure liquid chromatography and was found to be similar in nuclei and microsomes from MC-treated rats. After incubation of the nuclear fraction with [3H]BP and reduced nicotinamide adenine dinculeotide phosphate, radioactivity was found to be associated with nuclear DNA and the extent of binding was markedly enhanced by pretreatment of the animals with MC. Binding was strongly inhibited by a-napthoflavone but was not influenced by 1,1,1-trichloropropene-2,3-oxide, an inhibitor of epoxide hydrase. In the presence of microsomes from MC-treated rats, increased binding of BP to DNA was observed in nuclei from both control and MC-treated rats; moreover, when the nuclear DNA was replaced by a corresponding amount of calf thymus DNA, the extent of binding was severalfold enhanced. In contrast to nuclei from control rats, the nuclear fraction from MC-treated rats showed an increase in bound radioactivity when incubated with a microsome-free supernatant, obtained by incubating microsomes from MC-treated rats with [3H]BP. The increase in extent of binding was eliminated in the presence of menadione or alpha-naphthoflavone. It is suggested that under the conditions used here the following different processes may have contributed to the total incorporation of BP products into nuclear DNA: (a) formation of DNA-binding products derived from BP by nuclear aryl hydrocarbon hydroxylase; (b) formation of DNA-binding products from microsomal BP metabolites by nuclear aryl hydrocarbon hydroxylase; and (c) direct transfer of reactive microsomal metabolites to nuclear DNA.  (+info)

Nonenzymatic reduction of benzo(a)pyrene diol-epoxides to trihydroxypentahydrobenzo(a)pyrenes by reduced nicotinamide adenine dinucleotide phosphate. (4/611)

The diol-epoxide r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene is a potent mutagen and possibly the ultimate carcinogenic form of benzo(a)pyrene. A (7/8,9)-trihydroxy-7,8,9,10,10-pentahydrobenzo(a)pyrene is formed from the diol-epoxide r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydroxybenzo(a)pyrene by reduction with reduced nicotinamide adenine dinucleotide phosphate. Its formation is linear with reduced nicotinamide adenine dinucleotide phosphate concentration and does not require the presence of enzyme. A (7,9/8)-trihydroxy-7,8,9,10,10-pentahydrobenzo(a)pyrene is similarly formed from the diol-epoxide r-7,t-8-dihydroxy-c-9,10-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene by reduction with reduced nicotinamide adenine dinucleotide phosphate. The structures of the trihydroxypentahydrobenzo(a)pyrenes were established by their ultraviolet absorption and mass spectra and their reaction with potassium triacetylosmate.  (+info)

Use of tracheal organ cultures in toxicity testing. (5/611)

Fragments of tracheal epithelium alone or in continuity with connective tissues, can be maintained in culture medium and used for short term or long term studies of toxicity of a variety of chemicals. Large numbers of uniform cultures are prepared with the aid of a slicing device or by application of simple method for dissecting sheets of epithelium free from underlying cartilage. The cultures may be placed in an exposure chamber-incubator mounted on a microscope stage and monitored continually for ciliostasis and exfoliation of cells. Morphology is further studied by fixation of selected specimens and preparation for light microscopy and electron microscopy. Synthetic functions are evaluated by autoradiographic measurement of incorporation of radioactive precursors into macromolecules and other dynamic features are indirectly assessed by histochemical and histoenzymatic methods. Short-term studies using these several techniques have shown that ciliostasis does not correlate with cell injury in all instances, and a long-term study has demonstrated dose dependence of a cytotoxic agent when duration of culture viability is measured. The method lends itself to a broad range of investigations in which dose, period of exposure, and role of cofactors must be independently and quantitatively assessed.  (+info)

Biochemical studies of isolated hamster tracheal epithelium. (6/611)

The epithelial lining of respiratory air passageways is a primary target tissue for toxicity and carcinogenesis in man and in animal models of human disease. The importance of this target tissue was the basis for development of methods to study its biochemistry, and with this information to distinguish the unique properties of this tissue from properties common to all cell types. Biochemical methods employed labeling of macromolecules in isolated hamster treacheas during brief (less than 4 hr) incubation in vitro. Studies of RNA metabolism in isolated tracheas demonstrated a pattern of maturation of ribosomal RNA like that shown for other cell types. Alterations in RNA metabolism were observed in isolated tracheas obtained from vitamin A-deficient hamsters and hamsters previously treated by intratracheal administration of benzo[a]pyrene (BP) plus ferric oxide (Fe2O3) in vivo. Studies with toyocamycin, actinomycin D, and alpha-amanitin, all inhibitors of RNA metabolism, were performed to characterize the class of RNA molecules with a decreased proportion of labeling in tracheas from vitamin A deficient hamsters. In another series of experiments, BP was shown to bind to DNA in epithelial cells of isolated tracheas. The quantity of BP binding was increased by prior intratracheal treatment of hamsters with BP plus Fe2O3 in vivo, this induced binding was inhibited by addition of 7,8-benzoflavone to the incubation medium. Increased BP binding was also observed in isolated tracheas from hamsters believed to be in states of increased susceptibility to respiratory carcinogenesis in vivo. The results show that biochemical studies are feasible with this tissue. Furthermore, a number of questions of importance with regard to this target epithelium are best studied directly in its constituent cells.  (+info)

Comparison of cytochrome P450- and peroxidase-dependent metabolic activation of the potent carcinogen dibenzo[a,l]pyrene in human cell lines: formation of stable DNA adducts and absence of a detectable increase in apurinic sites. (7/611)

The potent carcinogen dibenzo[a,l]pyrene (DB[a,l]P) has been reported to form both stable and depurinating DNA adducts upon activation by cytochrome P450 enzymes and/or cellular peroxidases. Only stable DB[a,l]P-DNA adducts were detected in DNA after reaction of DB[a,I]P-11,12-diol-13,14-epoxides in solution or cells in culture. To determine whether DB[a,l]P can be activated to metabolites that form depurinating adducts in cells with either high peroxidase (human leukemia HL-60 cell line) or cytochrome P450 activity (human mammary carcinoma MCF-7 cell line), cultures were treated with DB[a,l]P for 4 h, and the levels of stable adducts and apurinic (AP) sites in the DNA were determined. DNA samples from DB[a,l]P-treated HL-60 cells contained no detectable levels of either stable adducts or AP sites. MCF-7 cells exposed to 2 microM DB[a,l]P for 4 h contained 4 stable adducts per 10(6) nucleotides, but no detectable increase in AP sites. The results indicate that metabolic activation of DB[a,l]P by cytochrome P450 enzymes to diol epoxides that form stable DNA adducts, rather than one-electron oxidation catalyzed either by cytochrome P450 enzymes or peroxidases to form AP sites, is responsible for the high carcinogenic activity of DB[a,l]P.  (+info)

Pathologic changes induced in respiratory tract mucosa by polycyclic hydrocarbons of differing carcinogenic activity. (8/611)

Seven aromatic polycyclic hydrocarbons (PCHs) were investigated for their toxic effects on respiratory mucosa: benzo(e)pyrene (BeP), pyrene, anthracene, benz(a)anthracene(BaA), dibenz(a,c)anthracene(DBacA), benzo (a)pyrene (BaP), and dimethylbenz(a)anthracene (DMBA). The compounds were chosen because they comprise a spectrum of PCHs ranging from noncarcinogens, to initiators, to weak and strong carcinogens. All of them except DMBA are environmentally relevant chemicals. The chemicals were tested over an 8-week period. Heterotopic tracheal transplants were continously exposed and the histopathologic effects induced by the various PCHs were periodically assessed semiquantitatively. All PCHs exhibited varying degrees of toxicity for respiratory epithelium and submucosa. BeP clearly showed the least toxicity followed by pyrene and anthracene. BaA and DBacA caused marked epithelial and submucosal changes. In addition to epithelial hyperplasia, undifferentiated epithelium and squamous metaplasia developed. Marked mononuclear infiltration occurred in the subepithelial connective tissue. With BaP the epithelial and submucosal changes were similar but were much stronger. DMBA was the most toxic substance, causing epithelial necrosis followed by generalized keratinizing squamous metaplasia; the subepithelial changes consisted of an early acellular exudate and, later (at 8 weeks), marked condensation and hyalinization of the lamina propria. The toxic response pattern of the tracheal mucosa to carcinogenic agents was characterized by the chronicity of epithelial and connective tissue damage, as opposed to the short-lived hyperplastic and inflammatory response elicited by the noncarcinogens and weak initiators.  (+info)

Formation of stable adducts and absence of depurinating DNA adducts in cells and DNA treated with the potent carcinogen dibenzo...Formation of stable adducts and absence of depurinating DNA adducts in cells and DNA treated with the potent carcinogen dibenzo...
Formation of stable adducts and absence of depurinating DNA adducts in cells and DNA treated with the potent carcinogen dibenzo [a, l] pyrene or its diol epoxides
https://horticulture.oregonstate.edu/biblio/formation-stable-adducts-and-absence-depurinating-dna-adducts-cells-and-dna-treated-potent
IJMS | Free Full-Text | In Vitro Metabolism of Dibenzo[a,l]pyrene, 2-Chlorodibenzo [a,l]pyrene and 10-Chlorodibenzo[a,l]pyrene ...IJMS | Free Full-Text | In Vitro Metabolism of Dibenzo[a,l]pyrene, 2-Chlorodibenzo [a,l]pyrene and 10-Chlorodibenzo[a,l]pyrene ...
Stereoselective metabolism of dibenzo[a,l]pyrene (DB[a,l]P), 2-chlorodibenzo[a,l]pyrene (2-Cl-DB[a,l]P) and 10-chlorodibenzo[a,l]pyrene (10-Cl-DB[a,l]P) by rat liver microsomes was studied and effects of the chloro substituent on the metabolism were determined. All three compounds produced trans-8,9-dihydrodiol, trans-11,12-dihydrodiol, and the 7-hydroxyl derivative as major metabolic products and several other phenolic derivatives as minor metabolites. The trans-8,9- and 11,12-dihydrodiols of DB[a,l]P and 2-Cl-DB[a,l]P preferentially adopted a quasidiequatorial conformation, whereas 10-Cl-DB[a,l]P trans-8,9- and 11,12-dihydrodiols preferentially adopted a quasidiaxial conformation. The yields of the trans-11,12-dihydrodiol metabolites are: DB[a,l]P trans-11,12-dihydrodiol | 2-Cl-DB[a,l]P trans-11,12-dihydrodiol || 10-Cl-DB[a,l]P trans-11,12-dihydrodiol. Circular dichroism (CD) spectral analysis indicates that the trans-8,9-dihydrodiol and trans-11,12-dihydrodiol metabolites from DB[a,l]P, 2-Cl-DB[a,l]P
http://www.mdpi.com/1422-0067/3/9/1008
What is a word ene meaning. Definition of ene.What is a word ene meaning. Definition of ene.
Words Ending In ene: acetylene,achene,advene,agene,akene,alkene,amene,aminobutene,amylene,anadyomene,anthracene,antigene,antivenene,arrasene,azobenzene,bene,benzanthracene,benzene,benzoapyrene,benzopyrene,benzpyrene,buckm
http://words-ending-in-ene.phraseinfo.com/e/
Cliff Pereiras PublicationsCliff Pereiras Publications
Siddens LK, Larin A, Krueger SK, Bradfield CA, Waters KM, Tilton SC, Pereira CB, Lohr CV, Arlt VM, Phillips DH, Williams DE and Baird WM (2012). Polycyclic aromatic hydrocarbons as skin carcinogens: Comparison of benzo[a]pyrene, dibenzo[def,p]chrysene and three environmental mixtures in the FVB/N mouse. Toxicology and Applied Pharmacology doi: 10.1016/j.taap.2012.08. ...
http://stat.oregonstate.edu/print/109
organic compound | AIVCorganic compound | AIVC
In dwellings and similar spaces with limited volume, dilution of indoor air contaminants may be insufficient. The concentration of contaminants in the inside air depends partly on the rate of emission into the room, partly on the ventilation and the concentration of impurities in the outside air. Sulphur dioxide, hydrocarbons, ozone and lead compounds occur in higher concentrations in the outside air, whereas nitrogen oxides, carbon monoxide, benzpyrene (from tobacco smoke), formaldehyde and dust have higher concentrations indoors. ...
https://www.aivc.org/keywords/organic-compound?page=30
8b,16b-Dihydrodibenzo[g,p]chrysene mixture of cis and trans8b,16b-Dihydrodibenzo[g,p]chrysene mixture of cis and trans
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
http://webbook.nist.gov/cgi/inchi/InChI%3D1S/C26H18/c1-5-13-21-17
ChemIDplus - 70133-84-5 - JZLWANHLFXZFCU-UHFFFAOYSA-N - 2-Chloro-12-(2-piperidinoethyl)dibenzo(d,g)-1,3,6-dioxazocine - Similar...ChemIDplus - 70133-84-5 - JZLWANHLFXZFCU-UHFFFAOYSA-N - 2-Chloro-12-(2-piperidinoethyl)dibenzo(d,g)-1,3,6-dioxazocine - Similar...
70133-84-5 - JZLWANHLFXZFCU-UHFFFAOYSA-N - 2-Chloro-12-(2-piperidinoethyl)dibenzo(d,g)-1,3,6-dioxazocine - Similar structures search, synonyms, formulas, resource links, and other chemical information.
https://chem.nlm.nih.gov/chemidplus/rn/70133-84-5
Molecules | Free Full-Text | Studies on the Interaction Mechanism of Pyrene Derivatives with Human Tumor-Related DNA | HTMLMolecules | Free Full-Text | Studies on the Interaction Mechanism of Pyrene Derivatives with Human Tumor-Related DNA | HTML
Pyrene derivatives can be carcinogenic, teratogenic and mutagenic, thus having the potential to cause malignant diseases. In this work, the interactions of two selected pyrene derivatives (1-OHP and 1-PBO) and human tumor-related DNA (p53 DNA and C-myc DNA) are investigated by spectroscopic and non-native polyacrylamide gel electrophoresis (PAGE) methods. Using fluorescence spectrometry and circular dichroism (CD), DNA interactions of pyrene derivatives are confirmed to occur mainly via the groove binding mode supported by the intercalation into the base pairs of DNA. There is an obvious binding order of pyrene derivatives to the targeted DNA, 1-OHP | 1-PBO. The binding constants of 1-OHP are 1.16 × 106 L×mol−1 and 4.04 × 105 L×mol−1 for p53 DNA and C-myc DNA, respectively, while that of 1-PBO are only 2.04 × 103 L×mol−1 and 1.39 × 103 L×mol−1 for p53 DNA and C-myc DNA, respectively. Besides, the binding of pyrene derivatives to p53 DNA is stronger than that for C-myc DNA. CD and PAGE
http://www.mdpi.com/1420-3049/17/12/14159/htm
Binding of isomers of benzo[a]pyrene diol-epoxide to chromatin<...Binding of isomers of benzo[a]pyrene diol-epoxide to chromatin<...
TY - JOUR. T1 - Binding of isomers of benzo[a]pyrene diol-epoxide to chromatin. AU - Kootstra, A.. AU - Slaga, T. J.. PY - 1980/4/14. Y1 - 1980/4/14. N2 - Both the carcinogenic B[a]P diol-epoxide (anti) and its relatively noncarcinogenic isomer, B[a]P diol-epoxide (syn), when reacted with chromatin in vitro, bind more extensively to the internucleosomal region of chromatin than to nucleosomes. These results suggest that the increased binding of B[a]P diol-epoxide (anti) to the internucleosomal region may have little relevance to the process of carcinogenesis.. AB - Both the carcinogenic B[a]P diol-epoxide (anti) and its relatively noncarcinogenic isomer, B[a]P diol-epoxide (syn), when reacted with chromatin in vitro, bind more extensively to the internucleosomal region of chromatin than to nucleosomes. These results suggest that the increased binding of B[a]P diol-epoxide (anti) to the internucleosomal region may have little relevance to the process of carcinogenesis.. UR - ...
https://scholars.uthscsa.edu/en/publications/binding-of-isomers-of-benzoapyrene-diol-epoxide-to-chromatin
Mutagenesis and carcinogenesis induced by dibenzo[a,l]pyrene in the mouse oral cavity: A potential new model for oral cancer<...Mutagenesis and carcinogenesis induced by dibenzo[a,l]pyrene in the mouse oral cavity: A potential new model for oral cancer<...
TY - JOUR. T1 - Mutagenesis and carcinogenesis induced by dibenzo[a,l]pyrene in the mouse oral cavity. T2 - A potential new model for oral cancer. AU - Guttenplan, Joseph B.. AU - Kosinska, Wieslawa. AU - Zhao, Zhong Lin. AU - Chen, Kun Ming. AU - Aliaga, Cesar. AU - Deltondo, Joseph. AU - Cooper, Timothy. AU - Sun, Yuan Wan. AU - Zhang, Shang Min. AU - Jiang, Kun. AU - Bruggeman, Richard. AU - Sharma, Arun K.. AU - Amin, Shantu. AU - Ahn, Kwangmi. AU - El-Bayoumy, Karam. N1 - Copyright: Copyright 2012 Elsevier B.V., All rights reserved.. PY - 2012/6/15. Y1 - 2012/6/15. N2 - Cancer of the oral cavity is a serious disease, affecting about 30,000 individuals in US annually. There are several animal models of oral cancer, but each has certain disadvantages. As a new model, we investigated whether topical application of the tobacco smoke carcinogen, dibenzo[a,l]pyrene (DB[a,l]P) is mutagenic and carcinogenic in the oral cavity of the B6C3F1 lacI and B6C3F1 mouse, respectively. B6C3F1 lacI mice ...
https://nyuscholars.nyu.edu/en/publications/mutagenesis-and-carcinogenesis-induced-by-dibenzoalpyrene-in-the-
Plus itPlus it
When [3H]benzo[a]pyrene is incubated in vitro together with deproteinized salmon sperm DNA, NADPH, and mouse liver microsomes, the covalent binding of benzo[a]pyrene metabolites to DNA occurs. The metabolite-nucleoside complexes can be resolved into at least nine distinct peaks by elution of a Sephadex LH-20 column with a water-methanol gradient. These peaks are arbitrarily designated A (most polar) through I (least polar). With the use of synthetic and biologically produced metabolites, seven of nine peaks are tentatively assigned to one or more metabolites of benzo[a]pyrene. Peaks A and C are unidentified. Peaks B, D, F, and I include products of benzo[a]pyrene quinones that are further metabolized. Peak E reflects almost exclusively both the cis- and trans-7,8-diol 9,10-epoxides of benzo[a]pyrene. Peak G represents predominantly the K-region metabolite (the 4,5-oxide), interacting with one or more nucleosides. Peak H comprises reactive intermediates resulting from the further metabolism of ...
http://molpharm.aspetjournals.org/content/14/2/306
Roberts Stochastic thoughts: 4/1/08 - 5/1/08Roberts Stochastic thoughts: 4/1/08 - 5/1/08
Butylated hydroxyanisole (BHA) is a commonly used food additive with demonstrated inhibitory action against chemical carcinogenesis in animals. In order to elucidate the mechanism of the anticarcinogenic action, the effects of BHA on benzo(a)pyrene (BP) metabolism were studied with lung microsomes from female mice. BHA treatment (0.5% in the diet for 7 days) inhibited BP metabolism and altered the ratios among different metabolites as analyzed by high-performance liquid chromatography. The treatment reduced the metabolic formation of 9,10-dihydroxy-9,10-dihydrobenzo(a)pyrene, but not the production of 3-hydroxybenzo(a)pyrene and trans-4,5-dihydroxy-4,5-dihydrobenzo(a)pyrene. Since the gross microsomal cytochrome P-450 content was not significantly affected by the treatment, the change of regioselectivity in BP metabolism was probably due to the alteration of cytochrome P-450 isozyme composition by dietary BHA. General and regioselective inhibition of BP metabolism was also observed when BHA was ...
http://rjwaldmann.blogspot.com/2008_04_01_archive.html
Advertisement In utero Exposure of Mice to Dibenzo[a,l]Pyrene Produces Lymphoma in the Offspring: Role of the Aryl Hydrocarbon...Advertisement In utero Exposure of Mice to Dibenzo[a,l]Pyrene Produces Lymphoma in the Offspring: Role of the Aryl Hydrocarbon...
Advertisement In utero Exposure of Mice to Dibenzo[a,l]Pyrene Produces Lymphoma in the Offspring: Role of the Aryl Hydrocarbon Receptor
https://bee.oregonstate.edu/biblio/advertisement-utero-exposure-mice-dibenzoalpyrene-produces-lymphoma-offspring-role-aryl
Carcinogenicity of benzo-ring derivatives of benzo(a)pyrene on mouse s by W Levin, A W. Wood et al.Carcinogenicity of benzo-ring derivatives of benzo(a)pyrene on mouse s by W Levin, A W. Wood et al.
Levin, W; Wood, A W.; Wislocki, P G.; Kapitulnik, J; Yagi, H; Jerina, D M.; and Conney, A H., Carcinogenicity of benzo-ring derivatives of benzo(a)pyrene on mouse skin. (1977). Subject Strain Bibliography 1977. 715 ...
https://mouseion.jax.org/ssbb1977/715/
Enzyme immunoassay of benzo[a]pyrene conjugated to DNA, RNA and microsomal proteins using a monoclonal antibody. - Semantic...Enzyme immunoassay of benzo[a]pyrene conjugated to DNA, RNA and microsomal proteins using a monoclonal antibody. - Semantic...
An enzyme immunoassay for the detection of benzo[a]pyrene covalently conjugated to macromolecules has been developed. The monoclonal antibody, raised through in vitro immunization reacted with benzo[a]pyrene metabolites bound to DNA, RNA and proteins. The lower detection limit for the assay was 1 pmol for benzo[a]pyrene bound to DNA or RNA, and 5 pmol when bound to protein.
https://www.semanticscholar.org/paper/Enzyme-immunoassay-of-benzo-a-pyrene-conjugated-to-Wallin-Borrebaeck/9877edcc0bbb0a62e3aa44ba46aab97c2e32a42f
192-97-2, benzo[e]pyrene, CAS No 192-97-2 benzo[e]pyrene nl192-97-2, benzo[e]pyrene, CAS No 192-97-2 benzo[e]pyrene nl
CAS NO:192-97-2; Chemical name:benzo[e]pyrene ; physical and chemical property of 192-97-2, benzo[e]pyrene is provided by ChemNet.com
http://www.chemnet.com/cas/nl/192-97-2/benzo%5Be%5Dpyrene.html
4.E: Mutation and Variation (Exercises) - Biology LibreTexts4.E: Mutation and Variation (Exercises) - Biology LibreTexts
4.1 Polymorphisms and mutations are both variations in DNA sequence and can arise through the same mechanisms. We use the term polymorphism to refer to DNA variants that are relatively common in populations. Mutations affect the phenotype.. 4.2 Misreading of bases during replication can lead to substitution and can be caused by things like tautomerism, DNA alkylating agents, and irradiation.. 4.3 Looping out of DNA on the template strand during replication; strand breakage, due to radiation and other mutagens; and (discussed in earlier chapters) chromosomal aberrations such as deletions and translocations.. 4.4 Looping out of DNA on the growing strand during replication; transposition; and (discussed in earlier chapters) chromosomal aberrations such as duplications, insertions, and translocation.. 4.5 Benzopyrene is one of many hazardous compounds present in smoke. Benzopyrene is an intercalating agent, which slides between the bases of the DNA molecule, distorting the shape of the double helix, ...
https://bio.libretexts.org/TextMaps/Map%3A_Online_Open_Genetics_
PQR | 9-(2-deoxy-5-o-phosphonopentofuranosyl)-n-(7,8,9-trihydroxy-7,8,9,10-tetrahydrobenzo[pqr]tetraphen-10-yl)-9h-purin-6-aminePQR | 9-(2-deoxy-5-o-phosphonopentofuranosyl)-n-(7,8,9-trihydroxy-7,8,9,10-tetrahydrobenzo[pqr]tetraphen-10-yl)-9h-purin-6-amine
You are viewing an interactive 3D depiction of the molecule 9-(2-deoxy-5-o-phosphonopentofuranosyl)-n-(7,8,9-trihydroxy-7,8,9,10-tetrahydrobenzo[pqr]tetraphen-10-yl)-9h-purin-6-amine (C30H14N5O9P) from the PQR.
http://pqr.pitt.edu/mol/PCKWPNBFFBGKTM-HGCLXHPZSA-N
DIBENZO[A,E]PYRENE UNLABELED - Creative ProteomicsDIBENZO[A,E]PYRENE UNLABELED - Creative Proteomics
Creative-Proteomics offer cas 192-65-4 DIBENZO[A,E]PYRENE UNLABELED. We are specialized in manufacturing Stabel Isotope Labeled Analytical Standard products.
https://www.creative-proteomics.com/product/detail-cpil100262_33602.htm
Influence of combined deficiency of fat and vitamin A on benzo(a)pyrene-induced lung carcinogenesis in rats. - Semantic ScholarInfluence of combined deficiency of fat and vitamin A on benzo(a)pyrene-induced lung carcinogenesis in rats. - Semantic Scholar
The present study shows the effect of combined dietary deprivation of fat and vitamin A on benzo(a)pyrene (BaP) induced lung carcinogenesis in male Wistar rats. Lung tumors were induced by intratracheal instillation of BaP-Fe2O3 in normal saline. The tumor incidence and tumor burden in control animals were 82% and 2.28 respectively. Fat deficiency decreased the tumor incidence to 57% and tumor burden to 1.66. On the other hand, in vitamin A deficiency these were 83% and 4.02 respectively. Fat deprivation in the diet of animals fed with vitamin A deficient diet decreased the tumor incidence and tumor burden to 69.6% and 2.7 respectively. The results suggest a protective role of low intake of fat in vitamin A deficiency for BaP-induced lung tumorigenesis in rats.
https://www.semanticscholar.org/paper/Influence-of-combined-deficiency-of-fat-and-vitami-Khanduja-Koul/c49dc9c96336c7dffc33186aba56f04d5033fb93
Formation of glucuronide, sulphate and glutathione conjugates of benzo by J Zaleski, S K. Bansal et al.Formation of glucuronide, sulphate and glutathione conjugates of benzo by J Zaleski, S K. Bansal et al.
Zaleski, J; Bansal, S K.; and Gessner, T, Formation of glucuronide, sulphate and glutathione conjugates of benzo[a]pyrene metabolites in hepatocytes isolated from inbred strains of mice. (1983). Subject Strain Bibliography 1983. 1888 ...
https://mouseion.jax.org/ssbb1983/1888/
Dibenzo[b,e]Thiepin-11(6H)-One 1531-77-7 MSDS, Safety Technical Specifications MSDSDibenzo[b,e]Thiepin-11(6H)-One 1531-77-7 MSDS, Safety Technical Specifications MSDS
Dibenzo[b,e]Thiepin-11(6H)-One 1531-77-7 MSDS report, Dibenzo[b,e]Thiepin-11(6H)-One MSDS safety technical specifications search, Dibenzo[b,e]Thiepin-11(6H)-One safety information specifications ect.
http://www.molbase.com/en/msds_1531-77-7-moldata-63963.html
6-methoxy-1,5-dihydrobenzo[cd]indol-4(3H)-one | C12H11NO2 - ChemSynthesis6-methoxy-1,5-dihydrobenzo[cd]indol-4(3H)-one | C12H11NO2 - ChemSynthesis
6-methoxy-1,5-dihydrobenzo[cd]indol-4(3H)-one - chemical structural formula, chemical names, chemical properties, synthesis references
http://www.chemsynthesis.com/base/chemical-structure-14805.html
Phenylethynyl-pyrene (PEP) in FluorophoresPhenylethynyl-pyrene (PEP) in Fluorophores
Phenylethynylpyrene (PEP) is a pyrene derivative with red-shifted absorption and emission spectra. Fits blue channel of qPCR instruments, can be used for multiplex experiments.
https://www.lumiprobe.com/t/fluorophores/phenylethynyl-pyrene
Trichloroepoxypropane Summary Report | CureHunterTrichloroepoxypropane Summary Report | CureHunter
Trichloroepoxypropane: A potent epoxide hydrase and aryl hydrocarbon hydroxylase inhibitor. It enhances the tumor-initiating ability of certain carcinogens.
http://www.curehunter.com/public/keywordSummaryD014239-Trichloroepoxypropane.do
dibenzo[b,d]furan-2-carbaldehyde | C13H8O2 - PubChemdibenzo[b,d]furan-2-carbaldehyde | C13H8O2 - PubChem
dibenzo[b,d]furan-2-carbaldehyde | C13H8O2 | CID 220843 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
https://pubchem.ncbi.nlm.nih.gov/compound/2-Dibenzofurancarboxaldehyde
Zelen j l - p rodn prost edek pro zdrav a kr su - P rodn kosmetika LadyBioZelen j l - p rodn prost edek pro zdrav a kr su - P rodn kosmetika LadyBio
Zelen j l - p rodn prost edek pro zdrav a kr su - J l je jednou z nejstar ch surovin, kter lov k za al vyu vat. A v kosmetice? - Redakce
https://m.ladybio.cz/clanky-zeleny-jil-prirodni-prostredek-pro-zdravi-a-krasu.html
Karaci er Absesi TedaviKaraci er Absesi Tedavi
E er karaci er absesi bakteriden kaynaklan yorsa, doktor ak t l p temizlenmesi i in kateterizasyon ve be hafta damardan antibiyotik verilmesini nerebilir. Bazen cerrahi m dahal
http://www.tedavin.com/sindirim-sistemi/499-karaciger-absesi-tedavi.html
Induction of Aryl Hydrocarbon Hydroxylase in Ambystoma tigrinum - Digital LibraryInduction of Aryl Hydrocarbon Hydroxylase in Ambystoma tigrinum - Digital Library
Aryl hydrocarbon hydroxylase (AHH) was induced 15-fold in Ambystoma tigrinum by intraperitoneal injection of 3-methylcholanthrene in corn oil, or 10-fold by addition of aromatic polycyclic hydrocarbons to the aqueous environment of the neotene animal. The cytochrome P-450-associated microsomal enzyme is similar to the inducible, one-gene, autosomal-dominant system typical in the laboratory mouse and man. Differences in optimal temperature for enzyme induction and activity were noted in organ culture of human and Ambystoma tissues, and ratios of benzpyrene metabolites differed between Ambystoma and Mus. The half life of enzyme activity induced in vivo was related to the excretion of hydrocarbon metabolites.
https://digital.library.unt.edu/ark:/67531/metadc663117/
NIOSHTIC-2 Publications Search - 00163633 - Effects of organic solvent vehicles on benzo[a]pyrene metabolism in rabbit lung...NIOSHTIC-2 Publications Search - 00163633 - Effects of organic solvent vehicles on benzo[a]pyrene metabolism in rabbit lung...
Effects of five organic solvent vehicles on benzo(a)pyrene- hydroxylase (BP-hydroxylase) activity and on the benzo(a)pyrene (50328) (BP) metabolite profile were studied in lung microsomes prepared from male New Zealand white rabbits. The production of 3- OH-benzo(a)pyrene (13345216) and 9-OH-benzo(a)pyrene (17573216) was used to evaluate the effects of dimethyl-sulfoxide (DMSO), acetone, methanol,
https://www.cdc.gov/niosh/nioshtic-2/00163633.html
Plus itPlus it
Two diol-epoxide metabolites of benzo[c]phenanthrene and benzo[a]pyrene, polynuclear aromatic hydrocarbons which occur in the environment, were tested for carcinogenicity by direct injection into the mammary fat pads of female CD rats. The compounds anti-3,4-dihydroxy-1,2-epoxy-1,2,3,4-tetrahydrobenzo[c]phenanthrene (BcPDE), a fjord region diol-epoxide, and anti-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene, a bay region diol-epoxide, were applied at total doses of 12.2 µmol. 6-Nitrochrysene was applied at the same dose as a positive control (K. El-Bayoumy, A. Rivenson, P. Upadhyaya, Y-H. Chae, and S. S. Hecht, Cancer Res. 53: 3719-3722, 1993). The sterically hindered fjord region diol-epoxide BcPDE was a powerful mammary tumorigen and carcinogen, rapidly inducing significantly more fibroadenoma and adenocarcinoma than either of the other compounds. Anti-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene was a weaker mammary tumorigen than BcPDE and 6-nitrochrysene. The ...
http://cancerres.aacrjournals.org/content/54/1/21
Biblio | Page 4 | College of Agricultural Sciences | Oregon State UniversityBiblio | Page 4 | College of Agricultural Sciences | Oregon State University
V. J. Melendez-Colon, Smith, C. Allen, Seidel, A., Luch, A., Platt, K. L., and Baird, W. M., Formation of stable adducts and absence of depurinating DNA adducts in cells and DNA treated with the potent carcinogen dibenzo [a, l] pyrene or its diol epoxides, Proceedings of the National Academy of Sciences, vol. 94, pp. 13542-13547, 1997. ...
https://bee.oregonstate.edu/biblio?page=3&%3Bf%5Bauthor%5D=4291&f%5Bauthor%5D=681
6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one Summary Report | CureHunter6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one Summary Report | CureHunter
6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one: inhibitor of cell adhesion and atherosclerosis that targets nadph oxidase
http://www.curehunter.com/public/keywordSummaryC438505-6-8-diallyl-5-7-dihydroxy-2--2-allyl-3-hydroxy-4-methoxyphenyl-1-H-benzo-b-pyran-4-one.do
ChemIDplus - 136623-01-3 - SCDBMLHUXJBJSS-UHFFFAOYSA-N - 5-Nitro-6,7,8,9-tetrahydrobenzo(G)indole-2,3-dione-3-oxime - Similar...ChemIDplus - 136623-01-3 - SCDBMLHUXJBJSS-UHFFFAOYSA-N - 5-Nitro-6,7,8,9-tetrahydrobenzo(G)indole-2,3-dione-3-oxime - Similar...
136623-01-3 - SCDBMLHUXJBJSS-UHFFFAOYSA-N - 5-Nitro-6,7,8,9-tetrahydrobenzo(G)indole-2,3-dione-3-oxime - Similar structures search, synonyms, formulas, resource links, and other chemical information.
https://chem.nlm.nih.gov/chemidplus/rn/136623-01-3
DSpace at EWHA: 1H-Benzo[f]indole-4,9-dione 과 1H-pyrrolo[3,2-g]quinoline-4,9-dione 합성 및 항진균 작용 연구DSpace at EWHA: 1H-Benzo[f]indole-4,9-dione 과 1H-pyrrolo[3,2-g]quinoline-4,9-dione 합성 및 항진균 작용 연구
Quinone 유도체들은 항진균, 항암, 항균, 항말라리아 등 다양한 생리활성을 나타낸다. 본 연구에서는 quinone 유도체 중 우수한 생리활성이 예상되는 quinone 유도체를 합성하여 항진균 작용 및 그 생리활성을 검색하였다. 1,4-Naphthoquinone을 ZnCl2를 촉매로 하여 ethyl benzoylacetate와 aryl thiol과 반응시켜 ethyl 5-oxo-2-phenyl-4-(phenylthio)-5,9b-dihydronaphtho[1,2-b]furan-3-carboxylate (NQMSs) 유도체 2개를 합성하였다. 2,3-Dichloro-5-hydroxynaphthalene-1,4-dione은 5-hydroxynaphthalene-1,4-dione를 Cl2 gas 와 반응시켜 합성하였고, 다양한 pyridine derivatives와 active methylene derivatives와 반응시켜 10-hydroxybenzo[f]pyrido[1,2-a]indole-6,11-dione (JQPMs) 유도체 9개를 합성하였다. 또 2,3-dichloro-5-hydroxynaphthalene-1,4-dione과 ethyl cyanoacetate를 반응시키고 다양한 arylamine을 반응시켜 ethyl ...
http://dspace.ewha.ac.kr/handle/2015.oak/213537
OPUS Würzburg | SearchOPUS Würzburg | Search
The lnfluence of mlcrosomal and nuclear aryl hydrocarbon hydroxylase (AHH) actlvlty on the covalent blndlng of [G·3H]benzo(a )pyrene to rat llver DNA was evaluated in viWJ. lnductlon of mlcrosomal AHH was obtalned alter phenobarbltal treatment (160% of control), whlch also lncreased DNA blndlng to 190%, but left the nuclear actlvlty unchanged. Nuclear AHH was lnduced wlth dleldrln (150%), and the blndlng was decreased to 75%, whereaa the mlcrosomal AHH was at control Ievei. The lncreaslng effect of mlcrosomal AHH lnductlon as weil as the decreaslng effect of nuclear AHH lnductlon on the blndlng was shown clearly when the data of the Individual rata were uaed to solve the equatlon Binding = e•(mlcroeomal AHH) + b•(nuclear AHH) + c Multiple linear regresslon analysls wlth the data from 10 anlmala reaulted ln positive valuea for a and c, a negative value for b, and a good multiple correlatlon coefflclent of r = 0.974. Pretreatment wlth 3-methylcholanthrene ln· duced mlcrosomal AHH to 380% of ...
https://opus.bibliothek.uni-wuerzburg.de/solrsearch/index/search/searchtype/all/rows/10/facetNumber_author_facet/all/institutefq/Institut+f%C3%BCr+Pharmakologie+und+Toxikologie/start/0/sortfield/year/sortorder/asc
ACRCF | ScientistsACRCF | Scientists
Chapel Hill, NC 27599-7525. Cells are particularly vulnerable to the cancer causing effects of chemicals if the treatments occur when the cells start to synthesize DNA during the cell growth cycle. Studies are probing the mechanisms that cause this susceptibility including identifying genomic sites replicated early in the DNA synthesis phase. A separate area of study concerns the development of endometrial cancer. Human endometrium has been reconstructed in culture from its constituent cells and interactions between endometrial epithelial and stromal cells determine normal tissue structure and function. The reconstructed endometrium has been used to reproduce progressive steps of endometrial cancer development in translational studies.. Previous studies showed that cells are most susceptible to malignant transformation when they are treated with chemical carcinogens during the earliest part of the S phase. DNA is also preferentially damaged when it replicates, with elevated carcinogen binding to ...
http://acrcf.org/research/scientists/
Benzo(a)pyrene-7,8-diol, 6-fluoro-7,8-dihydro- | C20H13FO2 - PubChemBenzo(a)pyrene-7,8-diol, 6-fluoro-7,8-dihydro- | C20H13FO2 - PubChem
Benzo(a)pyrene-7,8-diol, 6-fluoro-7,8-dihydro- | C20H13FO2 | CID 128565 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
https://pubchem.ncbi.nlm.nih.gov/compound/128565
China CAS NO.1609080-03-6 N-(m-tolyl)dibenzo[b,d]furan-4-amine Suppliers and Factory - Daken Chemical LimitedChina CAS NO.1609080-03-6 N-(m-tolyl)dibenzo[b,d]furan-4-amine Suppliers and Factory - Daken Chemical Limited
Daken Chemical Limited: Professional CAS NO.1609080-03-6 N-(m-tolyl)dibenzo[b,d]furan-4-amine suppliers in China. If youre going to buy or wholesale bulk OLED Intermediates at affordable price, welcome to get quotation from our factory.
http://m.dakentech.com/electronic-chemicals/oled-intermediates/n-m-tolyl-dibenzo-b-d-furan-4-amine-cas-no.html
RCSB PDB - 1JDG: Solution Structure of a Trans-Opened (10S)-dA Adduct of (+)-(7S,8R,9S,10R)-7,8-Dihydroxy-9,10-epoxy...RCSB PDB - 1JDG: Solution Structure of a Trans-Opened (10S)-dA Adduct of (+)-(7S,8R,9S,10R)-7,8-Dihydroxy-9,10-epoxy...
1JDG: Solution structure of a trans-opened (10S)-dA adduct of (+)-(7S,8R,9S,10R)-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene in a fully complementary DNA duplex: evidence for a major syn conformation.
http://www.rcsb.org/pdb/explore/explore.do?structureId=1JDG
Molcan :: Product DetailsMolcan :: Product Details
Quetiapine EP Impurity C ;. 2-(2-(4-(Dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl)ethoxy)ethyl 2-(4-(dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl)acetate ;. CAS # 1798840-31-9 ;. C40H42N6O3S2 ;. MW: 718.93. ...
http://molcan.com/products/3271
14,14,15,15-tetradehydro-7,7-spirobi[dibenzo... - Registration Dossier - ECHA14,14,15,15-tetradehydro-7,7-spirobi[dibenzo... - Registration Dossier - ECHA
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.. ...
https://echa.europa.eu/registration-dossier/-/registered-dossier/6054/4/6
High-pressure liquid chromatography (HPLC) is a m... - OpenStudyHigh-pressure liquid chromatography (HPLC) is a m... - OpenStudy
High-pressure liquid chromatography (HPLC) is a method used in chemistry and biochemistry to purify chemical substances. The pressures used in this p...
http://openstudy.com/updates/4f7b3c20e4b0884e12ab0eba
Lannett Co Inc (LCI) Holdings Cut by First Quadrant L P CA - Watch List NewsLannett Co Inc (LCI) Holdings Cut by First Quadrant L P CA - Watch List News
First Quadrant L P CA cut its holdings in Lannett Co Inc (NYSE:LCI) by 23.8% during the 3rd quarter, according to the company in its most recent disclosure with the SEC. The firm owned 15,400 shares of the companys stock after selling 4,800 shares during the quarter. First Quadrant L P CAs holdings in Lannett […]
https://www.watchlistnews.com/lannett-co-inc-lci-holdings-cut-by-first-quadrant-l-p-ca/1685139.html
FORMERON FAQ - AnabolicMinds.com - Page 14FORMERON FAQ - AnabolicMinds.com - Page 14
Brundel, dang, I dont like hearing that about 7, 8 benzoflavone . I was about to pick up several bottles of Dermacrine when they were back in stock.
http://anabolicminds.com/forum/black-lion-research/209597-formeron-faq-14.html
Officiella säkerhetsbetyg för Mercedes Benz C Class 2009Officiella säkerhetsbetyg för Mercedes Benz C Class 2009
Upptäck Euro NCAP:s Mercedes Benz C Class 2009 säkerhetsbedömning: detaljerade resultat, bilder, video och kommentarer till krocktest
https://www.euroncap.com/sv/results/mercedes-benz/c-class/11050
ایمنی‏زایی ناحیه‏ای اسیدهای آمینة 7601 تا 8140 از پروتئین Bap اسینتوباکتر بومانیایمنی‏زایی ناحیه‏ای اسیدهای آمینة 7601 تا 8140 از پروتئین Bap اسینتوباکتر بومانی
هدف: اسینتوباکتر بومانی یکی از پاتوژن‏های اصلی بیمارستانی است و ظرفیت بالایی برای مقاومت به انواع مواد ضد میکروبی موجود دارد. اسینتوباکتر بومانی انواع متفاوتی از عفونت‏ها شامل پنومونی، مننژیت و عفونت‏های مرتبط با خون را ایجاد می‏کند. پروتئین‏های مربوط به بیوفیلم (Bap) پروتئینی اختصاصی در سطح سلول است که مستقیماً در تشکیل بیوفیلم در اسینتوباکتر بومانی مورد نیاز است و نقش اصلی را در عفونت‏زایی باکتری بازی می‏کند. در مطالعه قبلی محققان حاضر نواحی متعددی از این پروتئین بررسی شد و با در نظر گرفتن معیارهای مختلف، چند ناحیه به عنوان نواحی حفاظت شده و ایمنی
http://mjms.modares.ac.ir/article_10451.html
DNA single strand breakage, DNA adducts, and sister chromatid exchange in lymphocytes and phenanthrene and pyrene metabolites...DNA single strand breakage, DNA adducts, and sister chromatid exchange in lymphocytes and phenanthrene and pyrene metabolites...
To investigate the specificity of biological monitoring variables (excretion of phenanthrene and pyrene metabolites in urine) and the usefulness of some biomarkers of effect (alkaline filter elution, {sup}32{end}P postlabeling assay, measurement of sister chromatid exchange)in workers exposed to polycyclic aromatic hydrocarbons (PAHs). 29 coke oven workers and a standardised control group were investigated for frequencies of DNA single strand breakage, DNA protein cross links (alkaline filter elution assay), sister chromatid exchange, and DNA adducts ({sup}32{end}P postlabeling assay) in lymphocytes. Phenanthrene and pyrene metabolites were measured in 24 hour urine samples. 19 different PAHs (including benzo(a)pyrene, pyrene, and phenanthrene) were measured at the workplace by personal air monitoring. The GSTT1 activity in erythrocytes and lymphocyte subpopulations in blood was also measured. Concentrations of phenanthrene, pyrene, and benzo(a)pyrene in air correlated well with the ...
http://connection.ebscohost.com/c/articles/8002898/dna-single-strand-breakage-dna-adducts-sister-chromatid-exchange-lymphocytes-phenanthrene-pyrene-metabolites-urine-coke-oven-workers
Deuterium isotope effects on 13C chemical shifts of 10-Hydroxybenzo[h]quinolines - Danish National Research Database-Den Danske...Deuterium isotope effects on 13C chemical shifts of 10-Hydroxybenzo[h]quinolines - Danish National Research Database-Den Danske...
Deuterium isotope effects on 13C-NMR chemical shifts are investigated in a series of 10-hydroxybenzo[h]quinolines (HBQs) The OH proton is deuteriated. The isotope effects on 13C chemical shifts in these hydrogen bonded systems are rather unusual. The formal four-bond effects are found to be negative, indicating transmission via the hydrogen bond. In addition unusual long-range effects are seen. Structures, NMR chemical shifts and changes in nuclear shieldings upon deuteriation are calculated using DFT methods. Two-bond deuterium isotope effects on 13C chemical shifts are correlated with calculated OH stretching frequencies. Isotope effects on chemical shifts are calculated for systems with OH exchanged by OD. Hydrogen bond potentials are discussed. New and more soluble nitro derivatives are synthesized ...
http://www.forskningsdatabasen.dk/catalog/240708244
Polycyclic hydrocarbon | Article about polycyclic hydrocarbon by The Free DictionaryPolycyclic hydrocarbon | Article about polycyclic hydrocarbon by The Free Dictionary
Looking for polycyclic hydrocarbon? Find out information about polycyclic hydrocarbon. polynuclear hydrocarbon Explanation of polycyclic hydrocarbon
http://encyclopedia2.thefreedictionary.com/polycyclic+hydrocarbon
In utero exposure of mice to dibenzo[a,l]pyrene produces lymphoma in the offspring: role of the aryl hydrocarbon receptor. |...In utero exposure of mice to dibenzo[a,l]pyrene produces lymphoma in the offspring: role of the aryl hydrocarbon receptor. |...
Lymphoma and leukemia are the most common cancers in children and young adults; in utero carcinogen exposure may contribute to the etiology of these cancers. A polycyclic aromatic hydrocarbon (PAH), dibenzo[a,l]pyrene (DBP), was given to pregnant mice (15 mg/kg body weight, gavage) on gestation day 17. Significant mortalities in offspring, beginning at 12 weeks of age, were observed due to an aggressive T-cell lymphoblastic lymphoma. Lymphocytes invaded numerous tissues. All mice surviving 10 months, exposed in utero to DBP, exhibited lung tumors; some mice also had liver tumors. To assess the role of the aryl hydrocarbon receptor (AHR) in DBP transplacental cancer, B6129SF1/J (AHR(b-1/d), responsive) mice were crossed with strain 129S1/SvIm (AHR(d/d), nonresponsive) to determine the effect of maternal and fetal AHR status on carcinogenesis. Offspring born to nonresponsive mothers had greater susceptibility to lymphoma, irrespective of offspring phenotype. However, when the mother was ...
https://superfund.oregonstate.edu/biblio/utero-exposure-mice-dibenzoalpyrene-produces-lymphoma-offspring-role-aryl-hydrocarbon
The effects of cytochrome P-450-448 inhibitors on the binding of benzo(a)pyrene and derivatives to DNA upon microsomal...The effects of cytochrome P-450-448 inhibitors on the binding of benzo(a)pyrene and derivatives to DNA upon microsomal...
1. [3H]Benzo(a)pyrene and 6-substituted derivatives of [3H]benzo(a)pyrene are covalently bound to calf thymus DNA upon reaction with microsomal preparations from rats pretreated with 3-methylcholanthrene in the presence of NADPH. Two different types of cytochrome P-450-448 inhibitors, alpha-naphthoflavone and 1-benzylimidazole, show greater than 80% inhibition of the binding of benzo(a)pyrene to DNA. 2. In the presence of these inhibitors, 6-hydroxymethylbenzo(a)pyrene, 6-methylbenzo(a)pyrene and 6-formylbenzo(a)pyrene show varying degrees of inhibition of binding to DNA depending upon the inhibitor employed. 3. Polyguanylic acid is the most effective substrate for the binding of each activated polynuclear aromatic hydrocarbon; polyadenylic acid and DNA show essentially equivalent binding. ...
https://www.meta.org/papers/the-effects-of-cytochrome-p-450-448-inhibitors-on/38576
Plus itPlus it
Environmental exposure to carcinogens may contribute to increasing breast cancer rates and geographic variation in breast cancer incidence in the United States. One class of chemicals that has received much attention are the polyaromatic hydrocarbons that are ubiquitous in the environment and occur in cigarette smoke. The cytochrome P450 1A1 (CYP1A1) gene codes for an enzyme that contributes to aryl hydrocarbon hydroxylase activity, which is involved in the metabolism of polyaromatic hydrocarbons. Genotypic variants of CYP1A1 have been associated with increased aryl hydrocarbon hydroxylase activity, and some epidemiological studies suggest that women with the variant genotype(s) are at increased risk for breast cancer.. We prospectively evaluated the associations between the CYP1A1 polymorphisms and breast cancer risk, as well as the potential modification of these associations by cigarette smoking, in a case-control study nested within the Nurses Health Study. We analyzed the T→C transition ...
http://cancerres.aacrjournals.org/content/58/4/667
Gdf11 - Inhibitors of Protein Methyltransferases as Chemical ToolsGdf11 - Inhibitors of Protein Methyltransferases as Chemical Tools
Background Benzo[a]pyrene(B[a]P), and its own greatest metabolite Benzo[a]pyrene 7,8-diol 9,10-epoxide (BPDE), are classic DNA damaging carcinogens. BPDE-DNA adducts. In addition, we found that the combined small alleles of rs3212986 and rs238406 were associated with a reduced DNA restoration capacity. Conclusions Our results claim that the version genotypes of rs3212986 and rs238406 are connected with reduced fix performance of BPDE induced DNA GDC-0973 harm, and may end up being predictive for somebodys DNA fix capability in response to environmental carcinogens. Launch Benzo[a]pyrene(B[a]P) is a vintage DNA harming carcinogen which is normally one of a variety of polycyclic aromatic hydrocarbons(PAHs) typically found in cigarette smoke cigarettes and in the ambient environment [1], [2]. Benzo[a]pyrene 7,8-diol 9,10-epoxide (BPDE), the best metabolite of B[a]P, forms covalent BPDE-DNA adducts within a cell that problems the framework and function of natural macromolecules such as for example ...
http://bio-naturlan.com/tag/gdf11/
NIOSHTIC-2 Publications Search - 00152353 - Inhibition of benzo(a)pyrene and benzo(a)pyrene-trans-7,8-diol metabolism and DNA...NIOSHTIC-2 Publications Search - 00152353 - Inhibition of benzo(a)pyrene and benzo(a)pyrene-trans-7,8-diol metabolism and DNA...
The effect of ellagic-acid (476664) on in-vitro metabolism of benzo(a)pyrene (50328) (BaP) or trans-7,8-dihydro-7,8- dihydroxybenzo(a)pyrene (trans BaP) by mouse lung explants was investigated. Explants were cultured for 16 hours in the presence or absence of 10 to 100 micromolar (microM) concentrations of the naturally occuring plant phenol. Ellagic-acid was then removed and explants were incubat
https://www.cdc.gov/niosh/nioshtic-2/00152353.html
The effects of high fat and high cholesterol diets on the disposition of Benzo(a)pyrene in the gut - ePrints SotonThe effects of high fat and high cholesterol diets on the disposition of Benzo(a)pyrene in the gut - ePrints Soton
The possible interactions of high dietary levels of fat (HF) or fat + cholesterol (HC) with the lipid-soluble carcinogen benzo(a)pyrene (BP) have been investigated in the male guinea pig. Bile was the major route of elimination of [^C]BP (25pCl i.v.) in normal animals, with a mean of 33% + a standard deviation of 13% of the dose excreted within 4h. Animals fed HF or HC diets showed a similar biliary elimination (27+13% and 37+15% respectively). However, the pattern of biliary metabolites was altered, such that a greater proportion of the recovered dose was present as BP dihydrodiols and their conjugates in HF and HC groups. The most marked increase was found in the 4,5-dihydrodiol glucuronide fraction, which increased from 2.4% of the C in bile to 13.5% and 11.6% in HF and HC groups respectively (p,0.01). Incubation of a number of BP metabolites with pure cultures of intestinal bacteria or guinea pig caecal contents resulted in hydrolysis of conjugated metabolites, particularly glucuronides, ...
https://eprints.soton.ac.uk/436117/
Evaluation of Accelerated Solvent Extraction of deuterated benzo(a)pyrene and dibenzo(a,i)pyrene from Diesel Standard Reference...Evaluation of Accelerated Solvent Extraction of deuterated benzo(a)pyrene and dibenzo(a,i)pyrene from Diesel Standard Reference...
Evaluation of Accelerated Solvent Extraction of deuterated benzo(a)pyrene and dibenzo(a,i)pyrene from Diesel Standard Reference Material 2975 ...
http://su.diva-portal.org/smash/record.jsf?pid=diva2:177320
Plus itPlus it
Mice were evaluated for their ability to form phenobarbital N-glucuronides. Following oral administration of [14C]phenobarbital to mice, a radiolabeled phenobarbital metabolite cochromatographed with synthetic standards of phenobarbital N-glucuronides. The phenobarbital N-glucuronides were partially purified from the mouse urine as phenobarbital N-methylglucuronates. The phenobarbital N-methylglucuronates isolated from mouse urine had similar chromatographic and spectroscopic properties as synthetic standards. The diastereomers of phenobarbital N-glucuronides and phenobarbital N-glucosides accounted for 7.8 +/- 2.3% and 1.6 +/- 0.6%, respectively, of the radioactivity excreted in mouse urine in the first 48 hr after dosing. This study indicates that the mouse may be a suitable species to study both N-glucosidation and N-glucuronidation simultaneously as metabolic pathways for barbiturates. ...
http://dmd.aspetjournals.org/content/23/5/548
In silico Modeling of Intracellular Diffusion and Reaction of Benzo[a]pyrene Diol EpoxideIn silico Modeling of Intracellular Diffusion and Reaction of Benzo[a]pyrene Diol Epoxide
PAHs are the reactive toxic chemical compounds which are present as environmental pollutants. These reactive compounds not only diffuse through the membranes of the cell but also partition into the membranes. They react with the DNA of the cell giving rise to toxicity and may cause cancer. To understand the cellular behavior of these foreign compounds, a mathematical model including the reaction-diffusion system and partitioning phenomenon has been developed. In order to reduce the complex structure of the cytoplasm due to the presence of many thin membranes, and to make the model less computationally expensive and numerically treatable, homogenization techniques have been used. The resulting complex system of PDEs generated from the model is implemented in Comsol Multiphysics. The numerical results obtained from the model show a nice agreement with the in vitro cell experimental results. Then the model was reduced to a system of ODEs, a compartment model (CM). The quantitative analysis of the ...
http://www.diva-portal.org/smash/record.jsf?pid=diva2:516280
Microbial Degradation of DDT.Microbial Degradation of DDT.
Over 110 marine bacteria were isolated and tested for their ability to convert DDT to water-soluble products. Forty-seven were found to convert 5% to 10% of the 14C-DDT to water-soluble products, 38 solubilized less than 5% of the insecticide, and 29 were apparently inactive by the test methods employed. Mucor alternans, a fungus exceptionally active in producing water-soluble metabolites from DDT, was used as a model for determining the identities of the water-soluble metabolites. Although these compounds have not yet been identified, they are not DDT, DDA, DBH, DBP, PCPA, or 2-chlorosuccinic acid. Therefore, previously uncharacterized products are probably formed by M. alternans. The hypothesis that nutrient availability is limiting DDT degradation is now being tested. For this purpose natural microbial communities of sea water containing bottom sediments are being subjected to a large number of different treatments in an attempt either to enrich for DDT-degrading organisms or to provide the
http://oai.dtic.mil/oai/oai?verb=getRecord&metadataPrefix=html&identifier=AD0762469
Plus itPlus it
The efficacy of a newly developed gas chromatography-negative ion chemical ionization-mass spectrometry-selected ion monitoring (GC-NICI-MS-SIM) assay for measuring globin adducts of benzo[a]pyrene (B[a]P) and chrysene diol epoxides in human was evaluated. In this pilot study, smokers and nonsmokers were selected as exposed and nonexposed groups. Using [2H12]r-7,t-8,9,c-10-tetrahydroxy-7,8,9,10-tetrahydrobenzo[a]pyren e ([2H12]trans,anti-B[a]P-tetraol) as an internal standard, B[a]P-tetraols released from globin after hydrolysis and derivatization were quantified by GC-NICI-MS-SIM. Levels of trans-1,2-dihydroxy-3,4-epoxy-1,2,3,4-tetrahydrochrysene (chrysene-DE)-globin adducts were estimated by assuming that the recovery and the MS response of the perdeuterated B[a]P-tetraol internal standard reflected the recovery and MS response of chrysene tetraols. The assay was found to be reproducible and sensitive enough to detect both analytes in all samples. The mean levels of B[a]P-tetraols released ...
http://cebp.aacrjournals.org/content/6/10/833
Analysis of DNA and protein adducts of benzo[a]pyrene in human tissues using structure-specific methodsAnalysis of DNA and protein adducts of benzo[a]pyrene in human tissues using structure-specific methods
We review studies which investigate the presence, using structure-specific analytical methods, of DNA or protein adducts of the carcinogen benzo[a]pyrene (BaP) in human tissues. The analytical methods include high performance liquid chromatography with fluorescence detection and gas chromatography-m …
https://pubmed.ncbi.nlm.nih.gov/12510015/?dopt=Abstract
Sarcoma-Producing Cell Lines Derived from Clones Transformed in vitro by Benzo[a]pyrene | ScienceSarcoma-Producing Cell Lines Derived from Clones Transformed in vitro by Benzo[a]pyrene | Science
Cells derived from mixed Syrian hamster embryo cultures were treated with pyrene (control) or with benzo[a]pyrene. Transformed clones were obtained only with the carcinogen. Some of the transformed clones were responsible for cell lines that produced tumors when injected into hamsters. These observations provide evidence that chemical-induced oncogenesis can be studied by an in vitro model. ...
http://science.sciencemag.org/content/165/3896/917
Scientists Identify Tobacco Damages DNA - Anomalous IntuitiveScientists Identify Tobacco Damages DNA - Anomalous Intuitive
So it mightve been great for news for life back in the day, but BaPs pose a serious environmental hazard to complex life. Being so common, organisms have evolved to work around BaP at the levels ambient sources (forest fires, a campfire, or an engine) can churn into our environments, but cigarette smoke delivers a huge dose (more than three times the levels of regular smoke) of the compounds directly into our lungs. Not good.. To keep us safe from environmental hazards, our bodies break down toxic compounds into smaller, inert molecules all the time. What happens with BaP is that this process breaks it down into stuff called benzo[α]pyrene diol epoxide (BPDE), which is actually more toxic than the initial hydrocarbon. BPDE chemically ties to DNA, forming a very strong bond (called an adduct) with guanine, one of the four nucleotide bases.. This alters the base enough that it becomes unreadable, so an affected cell wont be able to synthesize the proteins it encodes or pass on the information ...
http://www.anomalous.internet-how-to.com/scientists-identify-tobacco-damages-dna/
Benzo[a]pyrene (BaP) CASRN 50-32-8 | IRIS | US EPA, ORDBenzo[a]pyrene (BaP) CASRN 50-32-8 | IRIS | US EPA, ORD
Under EPAs Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005a), benzo[a]pyrene is carcinogenic to humans based on strong and consistent evidence in animals and humans ...
https://cfpub.epa.gov/ncea/iris2/chemicalLanding.cfm?substance_nmbr=136
THE HOMOGENEITY OF RAT-LIVER MICROSOMAL CYTOCHROME-P-448 ACTIVITY AND ITS ROLE IN THE ACTIVATION OF BENZO[A]PYRENE TO MUTAGENS ...THE HOMOGENEITY OF RAT-LIVER MICROSOMAL CYTOCHROME-P-448 ACTIVITY AND ITS ROLE IN THE ACTIVATION OF BENZO[A]PYRENE TO MUTAGENS ...
PHILLIPSON, CE, IOANNIDES, C, BARRETT, DCA and PARKE, DV (1985) THE HOMOGENEITY OF RAT-LIVER MICROSOMAL CYTOCHROME-P-448 ACTIVITY AND ITS ROLE IN THE ACTIVATION OF BENZO[A]PYRENE TO MUTAGENS ...
http://epubs.surrey.ac.uk/823360/
6-Bromobenzo(a)pyrene - Alfa Chemistry6-Bromobenzo(a)pyrene - Alfa Chemistry
Alfa Chemistry is the worlds leading provider for special chemicals. We offer qualified products for 21248-00-0(6-BROMOBENZO(a)PYRENE),please inquire us for 21248-00-0(6-BROMOBENZO(a)PYRENE).
http://www.alfa-chemistry.com/cas_21248-00-0.htm
Precursor and ProductPrecursor and Product
benzo[a]pyrene 50-32-8 Precursor and Downstream products, benzo[a]pyrene Precursor products, benzo[a]pyrene Downstream products ect.
http://www.molbase.com/en/precursor_50-32-8-moldata-49499.html
Dibenzo[c,e][1,2]dithiin-3,8-diamineDibenzo[c,e][1,2]dithiin-3,8-diamine
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
https://webbook.nist.gov/cgi/inchi/InChI%3D1S/C12H10N2S2/c13-7-1-3-9-10-4-2-8
What does BENZO stand for?What does BENZO stand for?
Looking for the definition of BENZO? Find out what is the full meaning of BENZO on Abbreviations.com! Benzocaine is one option -- get in to view more @ The Webs largest and most authoritative acronyms and abbreviations resource.
http://www.abbreviations.com/BENZO
C60@Fe4(1,6-bis(4-(((pyridin-2-yl)methylidene)amino)phenyl)pyrene)6(NTf2)8[email protected](1,6-bis(4-(((pyridin-2-yl)methylidene)amino)phenyl)pyrene)6(NTf2)8
Page contains details about [email protected](1,6-bis(4-(((pyridin-2-yl)methylidene)amino)phenyl)pyrene)6(NTf2)8 . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
http://nano.nature.com/nano/GR-M6006080
3-Methoxybenzo[a]pyrene - Alfa Chemistry3-Methoxybenzo[a]pyrene - Alfa Chemistry
3-Methoxybenzo[a]pyrene/ACM63059687 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
http://www.alfa-chemistry.com/cas_63059-68-7.htm
US6111110A - Synthesis of benzo[f]quinolinones - Google PatentsUS6111110A - Synthesis of benzo[f]quinolinones - Google Patents
A process for preparing intermediates and benzoquinolin-3-one pharmaceuticals, such pharmaceuticals are effective in treating conditions consequent on 5α-reductase.
https://patents.google.com/patent/US6111110
Vege Soup 菜湯: 想要除斑的看過來 & 美國總統夫人也是粉絲的Chris Benz小介紹Vege Soup 菜湯: 想要除斑的看過來 & 美國總統夫人也是粉絲的Chris Benz小介紹
8/1 Round Sensor Mirror Pro SIMPLEHUMAN(有買有保佑, 大不了被取消訂單, nordstrom周年慶的特價款, 玫瑰金, 最高等級的simple human化妝鏡, 有自動發亮功能的化妝鏡, 充一次電可以用很久, 不需要插著電線, 放大五倍跟放大十倍功能, 你可以自己選擇想要的光線, 我一直勾勾纏, 跟photodog說我想要買一個神奇的鏡子, 可以化妝得更漂亮! 當然是不能說價錢的, 哈哈, 可是我覺得有自然光的鏡子很重要耶, 可以避免畫出紅屁股或是唱戲的白臉, 尤其是光線不好的冬天, 或是暴風雨的停電夜, 有了這個鏡子你任何時候都可以畫得美美) ...
http://vegesoup.blogspot.com/2012/01/blog-post_17.html
Hogyan d ntenek az onkol gusok a kezel sr l? | Daganatok.huHogyan d ntenek az onkol gusok a kezel sr l? | Daganatok.hu
Mit jelent az a fogalom, hogy bizony t kokon alapul orvosl s? Milyen l p sekb l ll a v rhat an legink bb hat kony kezel si forma kiv laszt sa?
http://daganatok.hu/limfoma/orvosi-donteshozatal-az-onkohematologiai-betegek-kezeleseben-mikala-gabor-video
ParticulatesParticulates
These soot particles also carry carcinogens like benzopyrenes adsorbed on their surface. Particulate mass is not a proper ...
https://en.wikipedia.org/wiki/Particulates
Pacific Gas and Electric CompanyPacific Gas and Electric Company
4-benzopyrene and potassium chromate in mice drink". Arch Hyg Bakteriol. Carcinogens in water and soil. 152 (XXII): 45-53. ...
https://en.wikipedia.org/wiki/Pacific_Gas_and_Electric_Company
Hinkley groundwater contaminationHinkley groundwater contamination
4-benzopyrene and potassium chromate in mice drink". Arch Hyg Bakteriol. Carcinogens in water and soil. 152 (XXII): 45-53. PMID ...
https://en.wikipedia.org/wiki/Hinkley_groundwater_contamination
Arene oxideArene oxide
Benzopyrene is also converted to an epoxide, (+)-benzo[a]pyrene-7,8-epoxide. Benzene oxide (C6H6O) exists as an equilibrium ...
https://en.wikipedia.org/wiki/Arene_oxide
Jacques MillerJacques Miller
Miller, JF (1963). "Effect of thymectomy on the induction of skin tumours by 3,4-benzopyrene". Nature. 199 (4896): 920-2. ...
https://en.wikipedia.org/wiki/Jacques_Miller
EpoxideEpoxide
For prochiral arenes (naphthalene, toluene, benzoates, benzopyrene), the epoxides are often obtained in high enantioselectivity ...
https://en.wikipedia.org/wiki/Epoxide
Tobacco marketing targeting African AmericansTobacco marketing targeting African Americans
Brown began by explaining the ingredient menthol contains compounds such as benzopyrene, which is carcinogenic when smoked. He ...
https://en.wikipedia.org/wiki/Tobacco_marketing_targeting_African_Americans
Occupational cardiovascular diseaseOccupational cardiovascular disease
Associations also exist for exposure to arsenic, benzopyrenes, lead, dynamite, carbon disulphide, carbon monoxide, metalworking ...
https://en.wikipedia.org/wiki/Occupational_cardiovascular_disease
Del Amo (Superfund site)Del Amo (Superfund site)
... benzopyrene, phenanthrene and chrysene. Benzene is known to be a human carcinogen, and is detected most frequently and at the ...
https://en.wikipedia.org/wiki/Del_Amo_(Superfund_site)
Heterocyclic amine formation in meatHeterocyclic amine formation in meat
Most of the 20 HCAs are more toxic than benzopyrene, a carcinogen found in cigarette smoke and coal tar. MeIQ, IQ and 8-MeIQx ...
https://en.wikipedia.org/wiki/Heterocyclic_amine_formation_in_meat
Ernst WynderErnst Wynder
Wynder also discovered specific carcinogens in tar (e.g., benzopyrenes, arsenic), but was unable to identify the contributions ...
https://en.wikipedia.org/wiki/Ernst_Wynder
PyrenePyrene
Although it is not as problematic as benzopyrene, animal studies have shown pyrene is toxic to the kidneys and liver. It is now ...
https://en.wikipedia.org/wiki/Pyrene
Oil well fireOil well fire
Smoke from burnt crude oil contains many chemicals, including sulfur dioxide, carbon monoxide, soot, benzopyrene, Poly aromatic ...
https://en.wikipedia.org/wiki/Oil_well_fire
Smokers melanosisSmoker's melanosis
Smoking or the use of nicotine-containing drugs is the cause to Smoker's melanosis,. Also tar-components (benzopyrenes) are ...
https://en.wikipedia.org/wiki/Smoker's_melanosis
FAM185AFAM185A
... and benzopyrene. These interactions are not yet confirmed for the human protein, FAM185A. Currently, no diseases are known to ...
https://en.wikipedia.org/wiki/FAM185A
Smoking banSmoking ban
Sidestream smoke contains 69 known carcinogens, particularly benzopyrene and other polynuclear aromatic hydrocarbons, and ...
https://en.wikipedia.org/wiki/Smoking_ban
Mycobacterium vanbaaleniiMycobacterium vanbaalenii
3-methylcholanthrene and benzopyrene. First isolated from an environmental source, not known to be pathogenic. Strain PYR-1 = ...
https://en.wikipedia.org/wiki/Mycobacterium_vanbaalenii
ExcinucleaseExcinuclease
... damage may include thymine dimers created by UV rays as well as the bulky distortions in DNA caused by oxidized benzopyrenes ...
https://en.wikipedia.org/wiki/Excinuclease
GrillingGrilling
... benzopyrenes, and polycyclic aromatic hydrocarbons, which are carcinogens.Marination may reduce the formation of these ...
https://en.wikipedia.org/wiki/Grilling
List of MeSH codes (D04)List of MeSH codes (D04)
... benzopyrenes MeSH D04.615.799.306.300 - benzo(a)pyrene MeSH D04.615.799.306.400 - dihydroxydihydrobenzopyrenes MeSH D04.615. ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D04)
Project GaiaProject Gaia
... and carcinogens such as benzopyrene and benzene. The World Health Organization estimates that more than 4 million people die ...
https://en.wikipedia.org/wiki/Project_Gaia
KatsuobushiKatsuobushi
Due to the smoking process which involves tar and charcoal, amounts of benzopyrene exceeding EU standards, as much as 37μg per ...
https://en.wikipedia.org/wiki/Katsuobushi
List of MeSH codes (D12.776)List of MeSH codes (D12.776)
... benzopyrene hydroxylase MeSH D12.776.422.220.453.040.332 - cytochrome p-450 cyp1a1 MeSH D12.776.422.220.453.040.555 - ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776)
Harry GelboinHarry Gelboin
... benzopyrene, which occurs in tobacco smoke, auto exhaust, and other smoke-producing sources. His laboratory identified the ...
https://en.wikipedia.org/wiki/Harry_Gelboin
James Wilfred CookJames Wilfred Cook
... benzofenantrene 3.4-and 3.4-benzopyrene, and was therefore able to demonstrate for the first time that even a purely chemical ...
https://en.wikipedia.org/wiki/James_Wilfred_Cook
List of MeSH codes (D08)List of MeSH codes (D08)
... benzopyrene hydroxylase MeSH D08.244.453.040.555 - cytochrome p-450 cyp1a1 MeSH D08.244.453.040.777 - cytochrome p-450 cyp1a2 ... benzopyrene hydroxylase MeSH D08.811.682.690.708.170.040.332 - cytochrome p-450 cyp1a1 MeSH D08.811.682.690.708.170.040.443 - ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D08)
William Valentine MayneordWilliam Valentine Mayneord
... benzopyrene. He was among the first to measure gamma-radiation in "r" units. His precision measurements have stood the test of ...
https://en.wikipedia.org/wiki/William_Valentine_Mayneord
Agriculture Street LandfillAgriculture Street Landfill
"Press Park", a 56 townhouse housing complex in the area, has been found contaminated with benzopyrene at levels some 50 times ...
https://en.wikipedia.org/wiki/Agriculture_Street_Landfill
C20H12C20H12
... fluoranthene Benzopyrene Benzo[a]pyrene Benzo[e]pyrene Perylene This set index page lists chemical structure articles ...
https://en.wikipedia.org/wiki/C20H12
Indoor air pollution in developing nationsIndoor air pollution in developing nations
... benzopyrene, benzo(a)pyrene, dibenzopyrenes, dibenzocarbazoles, and cresols). In a typical solid fuel stove, about 6-20% of the ...
https://en.wikipedia.org/wiki/Indoor_air_pollution_in_developing_nations
Benzopyrene - WikipediaBenzopyrene - Wikipedia
A benzopyrene is an organic compound with the formula C20H12. Structurally speaking, the colorless isomers of benzopyrene are ... Benzopyrene is a component of pitch and occurs together with other related pentacyclic aromatic species such as picene, ... Two isomeric species of benzopyrene are benzo[a]pyrene and the less common benzo[e]pyrene. They belong to the chemical class of ... Benzopyrenes are harmful because they form carcinogenic and mutagenic metabolites (such as (+)-benzo[a]pyrene-7,8-dihydrodiol-9 ...
https://en.wikipedia.org/wiki/Benzopyrene
Benzopyrene dictionary definition | benzopyrene definedBenzopyrene dictionary definition | benzopyrene defined
and known to be a cause of cancer in animalssometimes called benz·py′rene Origin of benzopyrene benzo- + pyrene... ... benzopyrene definition: an aromatic hydrocarbon, CH, found in coal tar, cigarette smoke, etc. ... benzopyrene. ben·zo·py·rene. an aromatic hydrocarbon, CH, found in coal tar, cigarette smoke, etc. and known to be a cause of ... benzopyrene. noun. Either of two polycyclic aromatic hydrocarbons with the formula C20H12, found in coal tar and cigarette ...
http://www.yourdictionary.com/benzopyrene
Brazilian scientists examine how benzopyrene can cause cancerBrazilian scientists examine how benzopyrene can cause cancer
http://agencia.fapesp.br/with_prevention_in_mind_researchers_investigate_how_benzopyrene_can_cause_cancer_/26427/ ...
https://www.news-medical.net/news/20171023/Brazilian-scientists-examine-how-benzopyrene-can-cause-cancer.aspx
Canary Database: Browse by Exposure: BenzopyrenesCanary Database: Browse by Exposure: Benzopyrenes
Browse by Exposure: Benzopyrenes (5 articles). % of records by year: 1965 2017 ...
http://canarydatabase.org/browse/exposure/5082
Polycyclic Aromatic Hydrocarbons - Compounds, Benzo, Organic, and Benzopyrene - JRank Articles Polycyclic Aromatic Hydrocarbons - Compounds, Benzo, Organic, and Benzopyrene - JRank Articles
Benzopyrene, for example, is an organic chemical with the general formula C20H12, containing a five-ring structure. Benzopyrene ... Some of the better known polycyclic aromatic compounds in environmental chemistry include anthracene, benzopyrene, ... There are various isomers, or structural variants of benzopyrene which differ greatly in their toxicological properties. The ...
http://science.jrank.org/pages/5398/Polycyclic-Aromatic-Hydrocarbons.html
RCSB PDB - 2IA6: Bypass of Major Benzopyrene-dG Adduct by Y-Family DNA Polymerase with Unique Structural GapRCSB PDB - 2IA6: Bypass of Major Benzopyrene-dG Adduct by Y-Family DNA Polymerase with Unique Structural Gap
Bypass of Major Benzopyrene-dG Adduct by Y-Family DNA Polymerase with Unique Structural Gap. *DOI: 10.2210/pdb2IA6/pdb ...
https://www.rcsb.org/structure/2IA6
benzopyrene | Definition of benzopyrene in US English by Oxford Dictionariesbenzopyrene | Definition of benzopyrene in US English by Oxford Dictionaries
Definition of benzopyrene in US English - a compound that is the major carcinogen present in cigarette smoke. It also occurs in ... Burnt toast (and, for that matter, barbecued or smoked meats) contains increased levels of a known carcinogen, benzopyrene. ... Wood fires can also release benzopyrene, a carcinogen that can irritate your eyes, nose, throat, and lungs. ... he admitted that the examination of the controversial benzopyrene is not included in the normal importation inspection. ...
https://en.oxforddictionaries.com/definition/us/benzopyrene
Field evaluation of benzopyrene hydroxylase induction as a monitor for marine petroleum pollution | ScienceField evaluation of benzopyrene hydroxylase induction as a monitor for marine petroleum pollution | Science
Field evaluation of benzopyrene hydroxylase induction as a monitor for marine petroleum pollution ... Field evaluation of benzopyrene hydroxylase induction as a monitor for marine petroleum pollution ... Field evaluation of benzopyrene hydroxylase induction as a monitor for marine petroleum pollution ... Field evaluation of benzopyrene hydroxylase induction as a monitor for marine petroleum pollution ...
http://science.sciencemag.org/content/191/4230/945
Benzo pyrene-induced DNA adducts and gene expression profiles in target and non-target organs for carcinogenesis in mice. | MRCBenzo pyrene-induced DNA adducts and gene expression profiles in target and non-target organs for carcinogenesis in mice. | MRC
Benzo pyrene-induced DNA adducts and gene expression profiles in target and non-target organs for carcinogenesis in mice.. ... Benzo pyrene-induced DNA adducts and gene expression profiles in target and non-target organs for carcinogenesis in mice.. ...
http://www.environment-health.ac.uk/publications/benzo-pyrene-induced-dna-adducts-and-gene-expression-profiles-target-and-non-target
Particulates - WikipediaParticulates - Wikipedia
These soot particles also carry carcinogens like benzopyrenes adsorbed on their surface. Particulate mass is not a proper ...
https://en.wikipedia.org/wiki/Particulates
NIOSHTIC-2 Publications Search - 20041454 - Detection of polycyclic aromatic hydrocarbons (PAHS) in skin wipe samples of...NIOSHTIC-2 Publications Search - 20041454 - Detection of polycyclic aromatic hydrocarbons (PAHS) in skin wipe samples of...
NIOSHTIC-2 Publications Search - 20023853 - Biological monitoring for exposure to coal tar.NIOSHTIC-2 Publications Search - 20023853 - Biological monitoring for exposure to coal tar.
Benzopyrenes; Workplace-monitoring ...
https://www.cdc.gov/niosh/nioshtic-2/20023853.html
Sampling and Analytical Methods | Coal Tar Pitch Volatiles (CTPV), 58Sampling and Analytical Methods | Coal Tar Pitch Volatiles (CTPV), 58
3,4-benzopyrene; 6,7-benzopyrene. structure:. Figure 1.1.4. Benzene-soluble fraction (The sum of those components collected on ...
https://www.osha.gov/dts/sltc/methods/organic/org058/org058.html
2007 ATSDR Substance Priority List | Substance Priority List | ATSDR2007 ATSDR Substance Priority List | Substance Priority List | ATSDR
BENZOPYRENE. 603.00. 230. 073467-76-2. 227. CRESOLS. 602.74. 229. 001319-77-3. ...
https://www.atsdr.cdc.gov/spl/resources/2007_atsdr_substance_priority_list.html
마더세이프라운드 임옥룡 cs2 0406 - English마더세이프라운드 임옥룡 cs2 0406 - English
Benzopyrene ; metabolically activated to the diol-epoxide derivative ; benzopyrene-trans-7,8- dihydrodiol-9, 10-epoxide, a ...
https://www.slideshare.net/mothersafe/cs20406
Inhibition of benzo pyrene- and cyclophosphamide-induced mutagenicity by Cinnamomum cassia - ABIM - An Annotated Bibliography...Inhibition of benzo pyrene- and cyclophosphamide-induced mutagenicity by Cinnamomum cassia - ABIM - An Annotated Bibliography...
Inhibition of benzo pyrene- and cyclophosphamide-induced mutagenicity by Cinnamomum cassia. Type of publication:. Article / ... 2001) Inhibition of benzo pyrene- and cyclophosphamide-induced mutagenicity by Cinnamomum cassia. [Publication] ...
https://indianmedicine.eldoc.ub.rug.nl/10599/
Cyclobenzaprine - do this medication cause to to have a positive drug test?Cyclobenzaprine - do this medication cause to to have a positive drug test?
Would cyclobenzaprine test positive for a drug test as a benzopyrene?. Posted 25 Feb 2010 • 1 answer ...
https://www.drugs.com/answers/cyclobenzaprine-do-this-medication-cause-to-to-246892.html
Benzo(a)pyrene - WikipediaBenzo(a)pyrene - Wikipedia
"Benzopyrene and Vitamin A deficiency". Researcher links cigarettes, vitamin A and emphysema. Retrieved March 5, 2005.. ... "Levels of Benzopyrene in Burnt toasts". Guardian Unlimited, Special reports: Close encounters. Retrieved March 5, 2005.. ... The substance with the formula C20H12 is one of the benzopyrenes, formed by a benzene ring fused to pyrene. Its diol epoxide ... The compound is one of the benzopyrenes, formed by a benzene ring fused to pyrene, and is the result of incomplete combustion ...
https://en.wikipedia.org/wiki/Benzo%28a%29pyrene
Benzo(a)pyrene - WikipediaBenzo(a)pyrene - Wikipedia
"Benzopyrene and Vitamin A deficiency". Researcher links cigarettes, vitamin A and emphysema. Retrieved March 5, 2005.. ... 3,4-benzopyrene. 3,4-benz[a]pyrene. 3,4-benzo[a]pyrene. pentacyclo[10.6.2.02,7.09,19.016,20]icosa-1,3,5,7,9,11,13,15,17,19- ... "Levels of Benzopyrene in Burnt toasts". Guardian Unlimited, Special reports: Close encounters. Retrieved March 5, 2005.. ... The substance with the formula C20H12 is one of the benzopyrenes, formed by a benzene ring fused to pyrene. Its diol epoxide ...
https://en.wikipedia.org/wiki/Benzo
Category:Polycyclic aromatic hydrocarbons - Wikimedia CommonsCategory:Polycyclic aromatic hydrocarbons - Wikimedia Commons
Hidrocarburo aromático policíclico (es); Policiklusos aromás szénhidrogének (hu); Hidrokarburo aromatiko polizikliko (eu); hidrocarbur aromàtic policíclic (ca); polycyclische aromatische Kohlenwasserstoffe (de); هیدروکربن آروماتیک چندحلقه‌ای (fa); 多環芳香烴 (zh); Aromatiske kulbrinter (da); Polisiklik aromatik hidrokarbon (tr); 多環芳香族炭化水素 (ja); Polycykliska aromatiska kolväten (sv); פחמימנים ארומטיים רב-טבעתיים (he); 多環芳香烴 (zh-hant); 多环芳香烃 (zh-cn); 多环芳香烃 (wuu); Polysykliset aromaattiset hiilivedyt (fi); policikla aromata hidrokarbono (eo); polyaromatické uhlovodíky (cs); idrocarburi policiclici aromatici (it); hydrocarbure aromatique polycyclique (fr); Polütsüklilised aromaatsed süsivesinikud (et); 多環芳香烴 (zh-tw); Policikliniai aromatiniai angliavandeniliai
https://commons.wikimedia.org/wiki/Category:Polycyclic_aromatic_hydrocarbons
Mitochondrial DNA is a major cellular target for a dihydrodiol-epoxide derivative of benzo[a]pyreneMitochondrial DNA is a major cellular target for a dihydrodiol-epoxide derivative of benzo[a]pyrene
Benzopyrenes / metabolism* * Cell Line * Cell Nucleus / metabolism * DNA Replication / drug effects * DNA, Mitochondrial / ...
https://pubmed.ncbi.nlm.nih.gov/6770466/
Substance Priority List | ATSDRSubstance Priority List | ATSDR
BENZOPYRENE. 603. 73467-76-2. 231. CHLORDANE, TECHNICAL. 602. 12789-03-6. ...
https://www.atsdr.cdc.gov/spl/index.html
Profiling of Biomarkers for the Exposure of Polycyclic Aromatic Hydrocarbons: Lamin-A/C Isoform 3, Poly[ADP-ribose] Polymerase...Profiling of Biomarkers for the Exposure of Polycyclic Aromatic Hydrocarbons: Lamin-A/C Isoform 3, Poly[ADP-ribose] Polymerase...
... including curved backbone and cardiomegaly in zebrafish were observed in the 54 hpf with more than 400 nM of benzopyrene. In ... lamin-A/C isoform 3 and annexin A1 for benzopyrene; lamin-A/C isoform 3 and DNA topoisomerase 2-alpha for pentacene; poly[ADP- ... Benzopyrene (BaP) among 32 PAH compounds is notable for being the first chemical carcinogen to be discovered [2, 3]. ... DMSO, only DMSO-treatment as control; PARP-1, poly[ADP-ribose] polymerase 1; LMNA, lamin A/C; BaP, benzopyrene.. ...
https://www.hindawi.com/journals/bmri/2014/605135/
Antibodies against homogeneous epoxide hydratase provide evidence for a single enzyme hydrating styrene oxide and benz(a)pyrene...Antibodies against homogeneous epoxide hydratase provide evidence for a single enzyme hydrating styrene oxide and benz(a)pyrene...
Benzopyrenes / metabolism * Carcinogens / metabolism * Epoxide Hydrolases / immunology * Epoxide Hydrolases / metabolism* * ...
https://pubmed.ncbi.nlm.nih.gov/1250340/?dopt=Abstract
Benzo[a]pyrene (BaP) CASRN 50-32-8 | IRIS | US EPA, ORDBenzo[a]pyrene (BaP) CASRN 50-32-8 | IRIS | US EPA, ORD
3,4-Benzopyrene. *3,4-Benzpyren. *3,4-Benzpyrene. *3,4-Benzypyrene ...
https://cfpub.epa.gov/ncea/iris2/chemicalLanding.cfm?substance_nmbr=136
The frequency of polychromatic erythrocytes (PE) in the relation with erythrocytes normochromic (NE) in rats (R) treated whit...The frequency of polychromatic erythrocytes (PE) in the relation with erythrocytes normochromic (NE) in rats (R) treated whit...
Benzo[a]pyreneBenzo[a]pyrene
Other names: Benz[a]pyrene; 1,2-Benzpyrene; 3,4-Benzopyrene; 3,4-Benzpyrene; 3,4-Benz[a]pyrene; 6,7-Benzopyrene; Benzo[d,e,f] ... chrysene; B(a)P; BP; 3,4-Benzopirene; 3,4-Benzpyren; 3,4-BP; Rcra waste number U022; Benzopyrene; 4,5-Benzpyrene; NSC 21914; ...
https://webbook.nist.gov/cgi/cbook.cgi?ID=C50328&Units=CAL&Mask=FFFF
Cloning of differentially expressed cDNA sequences involved in malignant transformation induced by benzo(a)pyrene metabolite...Cloning of differentially expressed cDNA sequences involved in malignant transformation induced by benzo(a)pyrene metabolite...
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Benzopyrenes / Humans / DNA, Neoplasm / ... Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Benzopyrenes / Humans / DNA, Neoplasm / ... Benzopyrenes , Metabolism , Pharmacology , Carcinogens , Pharmacology , Cell Transformation, Neoplastic , Genetics , Cells, ... pyrene metabolite dihydroxyepoxy benzo pyrene (BPDE).,/p,,p,,b,METHOD,/b,The malignant transformation of human bronchial ...
https://search.bvsalud.org/gim/resource/en/wpr-301965
Black tea polyphenols restrict benzopyrene-induced mouse lung cancer progression through inhibition of Cox-2 and induction of...Black tea polyphenols restrict benzopyrene-induced mouse lung cancer progression through inhibition of Cox-2 and induction of...
Full text: Available Index: IMSEAR (South-East Asia) Main subject: Phenols / Tea / Benzopyrenes / Flavonoids / Catechin / ... Full text: Available Index: IMSEAR (South-East Asia) Main subject: Phenols / Tea / Benzopyrenes / Flavonoids / Catechin / ... Black tea polyphenols restrict benzopyrene-induced mouse lung cancer progression through inhibition of Cox-2 and induction of ... Animals , Animals, Newborn , Benzopyrenes , Biflavonoids/pharmacology , Blotting, Western , Caspase 3/metabolism , Catechin/ ...
https://search.bvsalud.org/gim/resource/en/sea-37471
Ozones Reaction with Common Chemicals from Ken Adachi (Sep. 29, 2006)Ozone's Reaction with Common Chemicals from Ken Adachi (Sep. 29, 2006)
BENZOPYRENE Formula C20H12. Reaction with Ozone: 3C20H12 + 46 O3 ---- , 60 CO2 + 18 H2O . Number of O2 molecules consumed per ... Benzopyrene, 37. EDTA (Ethylene Diamine Tetracetic Acid), 38. Ethanolamine, VI. SULFUR CONTAINING COMPOUNDS. This group breaks ...
http://educate-yourself.org/ozone/ozonereactionswithcommonchemicals29sep06.shtml
BenzoPyreneCarcinogenCarcinogensPolycyclic aromatic hydAmounts of benzopyreneCompoundsBenzeneCarcinogenicLungAntibodyIsomersCompoundCharcoalToxicityOrganicCigarettesHumansRatsCancersNeoplasticFoundLiverProductsMainDrugNormal
Benzo2
  • Two isomeric species of benzopyrene are benzo[a]pyrene and the less common benzo[e]pyrene. (wikipedia.org)
  • Benzopyrenes are harmful because they form carcinogenic and mutagenic metabolites (such as (+)-benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide from benzo[a]pyrene) which intercalate into DNA, interfering with transcription. (wikipedia.org)
Pyrene3
  • Structurally speaking, the colorless isomers of benzopyrene are pentacyclic hydrocarbons and are fusion products of pyrene and a phenylene group. (wikipedia.org)
  • The substance with the formula C 20 H 12 is one of the benzopyrenes , formed by a benzene ring fused to pyrene . (wikipedia.org)
  • The compound is one of the benzopyrenes , formed by a benzene ring fused to pyrene , and is the result of incomplete combustion at temperatures between 300 °C (572 °F) and 600 °C (1,112 °F). (wikipedia.org)
Carcinogen6
  • Burnt toast (and, for that matter, barbecued or smoked meats) contains increased levels of a known carcinogen, benzopyrene. (oxforddictionaries.com)
  • Benzopyrene (BaP) among 32 PAH compounds is notable for being the first chemical carcinogen to be discovered [ 2 , 3 ]. (hindawi.com)
  • Rospotrebnadzor claimed the chocolates contained increased amount of the carcinogen benzopyrene. (themoscowtimes.com)
  • Benzopyrene is considered both as pollutant and carcinogen. (thepinoy.com)
  • Their instant ramen produced in factories in China , and distributed through a massive - nearly global - network is under a recall for their products containing dangerous levels of benzopyrene , a carcinogen also found in coal tar and cigarettes. (giantrobot.com)
  • Benzopyrene is the most common carcinogen in the environment that results from burning fossil fuels. (honorearth.org)
Carcinogens2
  • Myristicin also assists in fighting prostate and colon cancers by neutralizing carcinogens, such as benzopyrene in smokes of cigarettes. (hubpages.com)
  • Parsley is a "chemoprotective" food because it may help neutralize a variety of carcinogens, including the benzopyrenes in cigarette smoke. (animalwellnessmagazine.com)
Polycyclic aromatic hyd1
  • In February 2014, NASA announced a greatly upgraded database for tracking polycyclic aromatic hydrocarbons (PAHs), including benzopyrene, in the universe. (wikipedia.org)
Amounts of benzopyrene2
  • Thus in most cases small amounts of benzopyrene are metabolized by gut enzymes prior to being passed on to the blood. (primidi.com)
  • The Korean Food and Drug Administration , as well as Nongshim are trying to respond to the backlash stating that the amounts of benzopyrene in the soup are minimal. (giantrobot.com)
Compounds3
  • Cooking food at temperatures over 180ºC promotes formation of several carcinogenic compounds, including aromatic hydrocarbon, benzopyrene, and heterocyclic amine (HCA). (mercola.com)
  • Exposure of food to high cooking temperatures (over 180ºC) such as with oven roasting or frying can lead to the formation of toxic carcinogenic compounds which include aromatic hydrocarbon, benzopyrene and heterocyclic amine. (mercola.com)
  • These are four volatile oil compounds that help neutralize the benzopyrenes found in cigarette smoke as well as in charcoal grill smoke. (hubpages.com)
Benzene1
  • Benzopyrene is extremely insoluble in water but very soluble in certain organic solvents such as benzene. (jrank.org)
Carcinogenic2
  • G]inseng exhibited beneficial effects on the detoxification of a carcinogenic compound, benzopyrene. (quackwatch.org)
  • Tar is sticky and brown, containing many chemicals known to be carcinogenic, including benzopyrene. (anabolicminds.com)
Lung2
  • Black tea polyphenols restrict benzopyrene-induced mouse lung cancer progression through inhibition of Cox-2 and induction of caspase-3 expression. (bvsalud.org)
  • Benzopyrene , found in tobacco smoke (including cigarette smoke), was shown to cause genetic damage in lung cells that was identical to the damage observed in the DNA of most malignant lung tumours. (primidi.com)
Antibody2
  • A team led by Prof. Arne Skerra from the Technical University of Munich (TUM) has deciphered the binding mechanism of an antibody to benzopyrene - a discovery that could pave the way for an easier method to identify and, hence, remove the toxin. (tum.de)
  • The antibody-based nanoprobe was used for in situ measurements of benzopyrene tetrol in single cells. (springer.com)
Isomers1
  • There are various isomers, or structural variants of benzopyrene which differ greatly in their toxicological properties. (jrank.org)
Compound3
  • A benzopyrene is an organic compound with the formula C20H12. (wikipedia.org)
  • Unless CYP1B1 is also knocked out, benzopyrene toxicity results from the bioactivation of benzopyrene to the ultimate toxic compound, benzopyrene -7,8-dihydrodiol-9,10-epoxide (see below). (primidi.com)
  • Other countries, such as Japan and the United States, did not set specific standards for benzopyrene in smoked fish products, but recommended its industries to voluntarily reduce the presence of the said organic compound to the lowest possible level," the statement read. (thepinoy.com)
Charcoal2
  • Fumes that develop from fat dripping on blistering charcoal are rich in benzopyrene, which can condense on grilled goods. (wikipedia.org)
  • Indirect cooking systems like this are recommended by the National Cancer Institute because they produce less benzopyrene than typical gas or charcoal grills. (wect.com)
Toxicity1
  • A recent study has found that cytochrome P450 1A1 (CYP1A1) and cytochrome P450 1B1 (CYP1B1) are both protective and, confusingly, necessary for benzopyrene toxicity . (primidi.com)
Organic1
  • Benzopyrene, for example, is an organic chemical with the general formula C 20 H 12 , containing a five-ring structure. (jrank.org)
Cigarettes1
  • Researchers estimated that every day the average infant under the age of two in urban America ingested 110 nanograms of benzopyrene, equivalent to smoking three cigarettes a day. (oxforddictionaries.com)
Humans1
  • It has been more difficult to link cancers to specific benzopyrene sources, especially in humans, and difficult to quantify risks posed by various methods of exposure (inhalation or ingestion). (primidi.com)
Rats2
  • The frequency of polychromatic erythrocytes (PE) in the relation with erythrocytes normochromic (NE) in rats (R) treated whit benzopyrene. (scholars.direct)
  • Benzopyrene was found to be behind the link , since it induces vitamin A deficiency in rats. (primidi.com)
Cancers1
  • A vast number of studies over the previous three decades have documented links between benzopyrene and cancers. (primidi.com)
Neoplastic1
  • Rights & permissions for article Metabolic degradation of 3,4-benzopyrene in the cultures of normal and neoplastic fibroblasts. (nature.com)
Found4
  • Tests of medications purchased online have found PCBs (polychlorinated biphenyls) and benzopyrenes in fake medication purchased for the tests. (safemedicines.org)
  • A 2001 National Cancer Institute study found levels of benzopyrene to be significantly higher in foods that were cooked well-done on the barbecue, particularly steaks, chicken with skin, and hamburgers. (primidi.com)
  • In a statement, it said KFDA had conducted a thorough test and issued a certificate on Nov. 7, 2012 saying that the level of benzopyrene found in the noodle powder-which ranges from 0.4 to 1.6 ppb-"was extremely low and has no harmful effect on the human body. (thepinoy.com)
  • Back in the 80's researchers at Lawrence Livermore Labs in California, found that breast cells growing in culture exposed to benzopyrene had altered genetic make-up. (honorearth.org)
Liver1
  • Fish from petroleum-contaminated sites in the marine environment have elevated levels of benzopyrene hydroxylase activity in liver and gill tissue. (sciencemag.org)
Products1
  • There are 6 products that have been identified as containing "dangerous" levels of benzopyrene, including some of the most popular products from the brand. (giantrobot.com)
Main1
  • NER is the main mechanism used to remove pyrimidine dimers induced by UV cross-linking or chemical damage such as those caused by benzopyrene, aflatoxin, and cisplatin. (oxforddictionaries.com)
Drug1
  • Would cyclobenzaprine test positive for a drug test as a benzopyrene? (drugs.com)
Normal1
  • Although legally imported olive oil has passed the required quarantine inspection, he admitted that the examination of the controversial benzopyrene is not included in the normal importation inspection. (oxforddictionaries.com)
NIOSHTIC-2 Publications Search - 20023853 - Biological monitoring for exposure to coal tar.
NIOSHTIC-2 Publications Search - 20023853 - Biological monitoring for exposure to coal tar. (cdc.gov)
Category:Polycyclic aromatic hydrocarbons - Wikimedia Commons
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BCPI Brochures - Breast Cancer Prevention Institute
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The top 3 must do longevity tips in order to avoid mitochondrial dise…
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Do You Know The 5 Kinds Of Poisons That Are Found In Counterfeit Medicines? - Partnership for Safe Medicines
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Extra Virgin Olive Oil Fraud: A Guide to Purchasing Olive Oil
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BCPI Booklets - Breast Cancer Prevention Institute
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Top 10 healing herbs for dogs | Animal Wellness Magazine
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US5470544A - System for steam-reforming of liquid or slurry feed material - Google Patents
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QUESTION FROM READER:VITAMIN K AND CANCER - Healthy.net
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Cupboard Champs! 14 Common Kitchen Herbs that pack a Powerful Punch! - Alternative Medicine Magazine
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