Benzopyrenes
Polycyclic Hydrocarbons, Aromatic
A major group of unsaturated cyclic hydrocarbons containing two or more rings. The vast number of compounds of this important group, derived chiefly from petroleum and coal tar, are rather highly reactive and chemically versatile. The name is due to the strong and not unpleasant odor characteristic of most substances of this nature. (From Hawley's Condensed Chemical Dictionary, 12th ed, p96)
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Benzo(a)pyrene
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Pregnancy Outcome
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Amitriptyline
Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
Muscle Relaxants, Central
A heterogeneous group of drugs used to produce muscle relaxation, excepting the neuromuscular blocking agents. They have their primary clinical and therapeutic uses in the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. They have been used also for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in MULTIPLE SCLEROSIS. (From Smith and Reynard, Textbook of Pharmacology, 1991, p358)
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Inosine
A purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It is an intermediate in the degradation of purines and purine nucleosides to uric acid and in pathways of purine salvage. It also occurs in the anticodon of certain transfer RNA molecules. (Dorland, 28th ed)
DNA-Directed DNA Polymerase
DNA-dependent DNA polymerases found in bacteria, animal and plant cells. During the replication process, these enzymes catalyze the addition of deoxyribonucleotide residues to the end of a DNA strand in the presence of DNA as template-primer. They also possess exonuclease activity and therefore function in DNA repair.
DNA Adducts
DNA Polymerase III
A DNA-dependent DNA polymerase characterized in E. coli and other lower organisms but may be present in higher organisms. Use also for a more complex form of DNA polymerase III designated as DNA polymerase III* or pol III* which is 15 times more active biologically than DNA polymerase I in the synthesis of DNA. This polymerase has both 3'-5' and 5'-3' exonuclease activities, is inhibited by sulfhydryl reagents, and has the same template-primer dependence as pol II. EC 2.7.7.7.
The direct spectrophotometric observation of benzo(a)pyrene phenol formation by liver microsomes. (1/611)
Optical spectral repetitive scan analysis during the oxidative metabolism of benzo(a)pyrene by liver microsomal suspensions reveals the time-dependent formation of an intermediate(s) of which the visible spectra resemble those of several benzo(a)pyrene phenols. Liver microsomes from 3-methylcholanthrene-treated rats showed a greater rate of formation of the phenols than did microsomes from control animals; the rate of formation catalyzed by liver microsomes from phenobarbital-pretreated rats was intermediate. When 3-hydroxybenzo(a)pyrene was used as a standard for comparison of activity, the rates of formation of phenols were compared when measured by fluorometric, spectrophotometric, or high-pressure liquid chromatographic analytical techniques. An epoxide hydrase inhibitor, 1,1,1-trichloropropene-2,3-oxide, enhanced phenol formation regardless of the source of liver microsomes, and 7,8-benzoflavone inhibited control and 3-methylcholanthrene-induced microsomal metabolism of benzo(a)pyrene, 7,8-Benzoflavone did not effect benzo(a)pyrene metabolism by liver microsomes from phenobarbital-pretreated rats. The effect of inhibitors on the spectrophotometric assay correlates well with the results obtained from benzo(a)pyrene metabolite analysis using high-pressure liquid chromatography. (+info)Differences in benzo(a)pyrene metabolism between rodent liver microsomes and embryonic cells. (2/611)
Differences in benzo(a)pyrene metabolite pattern have been shown by rodent liver microsomes (Sprague-Dawley) and rodent embryo cells from Syrian hamsters and NIH Swiss mice. Rodent liver induced by methylcholanthrene shows marked quantitative variation between species. Additional pattern changes were found in mouse and hamster embryo secondary cultures with a reduction of the K-region metabolites and a marked increase in 9-hydroxybenzo(a)-pyrene. These results are indicative of a region-specific attack on the carcinogen by the cell monooxygenases which is distinct from the liver attack of microsomal enzymes on benzo(a)pyrene. These results suggest that activation and detoxification of benzo(a)pyrene may be species and tissue variable, and susceptibility and resistence to malignant transformation may be predicted on induction of a fortuitous combination of intermediate metabolic steps. (+info)Formation in isolated rat liver microsomes and nuclei of benzo(a)pyrene metabolites that bind to DNA. (3/611)
The hepatic nuclear fraction isolated from 3-methylcholanthrene (MC)-treated rats contained enhanced levels of cytochrome P-450 and aryl hydrocarbon hydroxylase [benzo(a)pyrene (BP) monooxygenase], whereas the activities of epoxide hydrase and reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase and the concentration of cytochrome b5 were not altered. The metabolite pattern of BP was investigated by using high-pressure liquid chromatography and was found to be similar in nuclei and microsomes from MC-treated rats. After incubation of the nuclear fraction with [3H]BP and reduced nicotinamide adenine dinculeotide phosphate, radioactivity was found to be associated with nuclear DNA and the extent of binding was markedly enhanced by pretreatment of the animals with MC. Binding was strongly inhibited by a-napthoflavone but was not influenced by 1,1,1-trichloropropene-2,3-oxide, an inhibitor of epoxide hydrase. In the presence of microsomes from MC-treated rats, increased binding of BP to DNA was observed in nuclei from both control and MC-treated rats; moreover, when the nuclear DNA was replaced by a corresponding amount of calf thymus DNA, the extent of binding was severalfold enhanced. In contrast to nuclei from control rats, the nuclear fraction from MC-treated rats showed an increase in bound radioactivity when incubated with a microsome-free supernatant, obtained by incubating microsomes from MC-treated rats with [3H]BP. The increase in extent of binding was eliminated in the presence of menadione or alpha-naphthoflavone. It is suggested that under the conditions used here the following different processes may have contributed to the total incorporation of BP products into nuclear DNA: (a) formation of DNA-binding products derived from BP by nuclear aryl hydrocarbon hydroxylase; (b) formation of DNA-binding products from microsomal BP metabolites by nuclear aryl hydrocarbon hydroxylase; and (c) direct transfer of reactive microsomal metabolites to nuclear DNA. (+info)Nonenzymatic reduction of benzo(a)pyrene diol-epoxides to trihydroxypentahydrobenzo(a)pyrenes by reduced nicotinamide adenine dinucleotide phosphate. (4/611)
The diol-epoxide r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene is a potent mutagen and possibly the ultimate carcinogenic form of benzo(a)pyrene. A (7/8,9)-trihydroxy-7,8,9,10,10-pentahydrobenzo(a)pyrene is formed from the diol-epoxide r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydroxybenzo(a)pyrene by reduction with reduced nicotinamide adenine dinucleotide phosphate. Its formation is linear with reduced nicotinamide adenine dinucleotide phosphate concentration and does not require the presence of enzyme. A (7,9/8)-trihydroxy-7,8,9,10,10-pentahydrobenzo(a)pyrene is similarly formed from the diol-epoxide r-7,t-8-dihydroxy-c-9,10-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene by reduction with reduced nicotinamide adenine dinucleotide phosphate. The structures of the trihydroxypentahydrobenzo(a)pyrenes were established by their ultraviolet absorption and mass spectra and their reaction with potassium triacetylosmate. (+info)Use of tracheal organ cultures in toxicity testing. (5/611)
Fragments of tracheal epithelium alone or in continuity with connective tissues, can be maintained in culture medium and used for short term or long term studies of toxicity of a variety of chemicals. Large numbers of uniform cultures are prepared with the aid of a slicing device or by application of simple method for dissecting sheets of epithelium free from underlying cartilage. The cultures may be placed in an exposure chamber-incubator mounted on a microscope stage and monitored continually for ciliostasis and exfoliation of cells. Morphology is further studied by fixation of selected specimens and preparation for light microscopy and electron microscopy. Synthetic functions are evaluated by autoradiographic measurement of incorporation of radioactive precursors into macromolecules and other dynamic features are indirectly assessed by histochemical and histoenzymatic methods. Short-term studies using these several techniques have shown that ciliostasis does not correlate with cell injury in all instances, and a long-term study has demonstrated dose dependence of a cytotoxic agent when duration of culture viability is measured. The method lends itself to a broad range of investigations in which dose, period of exposure, and role of cofactors must be independently and quantitatively assessed. (+info)Biochemical studies of isolated hamster tracheal epithelium. (6/611)
The epithelial lining of respiratory air passageways is a primary target tissue for toxicity and carcinogenesis in man and in animal models of human disease. The importance of this target tissue was the basis for development of methods to study its biochemistry, and with this information to distinguish the unique properties of this tissue from properties common to all cell types. Biochemical methods employed labeling of macromolecules in isolated hamster treacheas during brief (less than 4 hr) incubation in vitro. Studies of RNA metabolism in isolated tracheas demonstrated a pattern of maturation of ribosomal RNA like that shown for other cell types. Alterations in RNA metabolism were observed in isolated tracheas obtained from vitamin A-deficient hamsters and hamsters previously treated by intratracheal administration of benzo[a]pyrene (BP) plus ferric oxide (Fe2O3) in vivo. Studies with toyocamycin, actinomycin D, and alpha-amanitin, all inhibitors of RNA metabolism, were performed to characterize the class of RNA molecules with a decreased proportion of labeling in tracheas from vitamin A deficient hamsters. In another series of experiments, BP was shown to bind to DNA in epithelial cells of isolated tracheas. The quantity of BP binding was increased by prior intratracheal treatment of hamsters with BP plus Fe2O3 in vivo, this induced binding was inhibited by addition of 7,8-benzoflavone to the incubation medium. Increased BP binding was also observed in isolated tracheas from hamsters believed to be in states of increased susceptibility to respiratory carcinogenesis in vivo. The results show that biochemical studies are feasible with this tissue. Furthermore, a number of questions of importance with regard to this target epithelium are best studied directly in its constituent cells. (+info)Comparison of cytochrome P450- and peroxidase-dependent metabolic activation of the potent carcinogen dibenzo[a,l]pyrene in human cell lines: formation of stable DNA adducts and absence of a detectable increase in apurinic sites. (7/611)
The potent carcinogen dibenzo[a,l]pyrene (DB[a,l]P) has been reported to form both stable and depurinating DNA adducts upon activation by cytochrome P450 enzymes and/or cellular peroxidases. Only stable DB[a,l]P-DNA adducts were detected in DNA after reaction of DB[a,I]P-11,12-diol-13,14-epoxides in solution or cells in culture. To determine whether DB[a,l]P can be activated to metabolites that form depurinating adducts in cells with either high peroxidase (human leukemia HL-60 cell line) or cytochrome P450 activity (human mammary carcinoma MCF-7 cell line), cultures were treated with DB[a,l]P for 4 h, and the levels of stable adducts and apurinic (AP) sites in the DNA were determined. DNA samples from DB[a,l]P-treated HL-60 cells contained no detectable levels of either stable adducts or AP sites. MCF-7 cells exposed to 2 microM DB[a,l]P for 4 h contained 4 stable adducts per 10(6) nucleotides, but no detectable increase in AP sites. The results indicate that metabolic activation of DB[a,l]P by cytochrome P450 enzymes to diol epoxides that form stable DNA adducts, rather than one-electron oxidation catalyzed either by cytochrome P450 enzymes or peroxidases to form AP sites, is responsible for the high carcinogenic activity of DB[a,l]P. (+info)Pathologic changes induced in respiratory tract mucosa by polycyclic hydrocarbons of differing carcinogenic activity. (8/611)
Seven aromatic polycyclic hydrocarbons (PCHs) were investigated for their toxic effects on respiratory mucosa: benzo(e)pyrene (BeP), pyrene, anthracene, benz(a)anthracene(BaA), dibenz(a,c)anthracene(DBacA), benzo (a)pyrene (BaP), and dimethylbenz(a)anthracene (DMBA). The compounds were chosen because they comprise a spectrum of PCHs ranging from noncarcinogens, to initiators, to weak and strong carcinogens. All of them except DMBA are environmentally relevant chemicals. The chemicals were tested over an 8-week period. Heterotopic tracheal transplants were continously exposed and the histopathologic effects induced by the various PCHs were periodically assessed semiquantitatively. All PCHs exhibited varying degrees of toxicity for respiratory epithelium and submucosa. BeP clearly showed the least toxicity followed by pyrene and anthracene. BaA and DBacA caused marked epithelial and submucosal changes. In addition to epithelial hyperplasia, undifferentiated epithelium and squamous metaplasia developed. Marked mononuclear infiltration occurred in the subepithelial connective tissue. With BaP the epithelial and submucosal changes were similar but were much stronger. DMBA was the most toxic substance, causing epithelial necrosis followed by generalized keratinizing squamous metaplasia; the subepithelial changes consisted of an early acellular exudate and, later (at 8 weeks), marked condensation and hyalinization of the lamina propria. The toxic response pattern of the tracheal mucosa to carcinogenic agents was characterized by the chronicity of epithelial and connective tissue damage, as opposed to the short-lived hyperplastic and inflammatory response elicited by the noncarcinogens and weak initiators. (+info)
Formation of stable adducts and absence of depurinating DNA adducts in cells and DNA treated with the potent carcinogen dibenzo...
IJMS | Free Full-Text | In Vitro Metabolism of Dibenzo[a,l]pyrene, 2-Chlorodibenzo [a,l]pyrene and 10-Chlorodibenzo[a,l]pyrene ...
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Application of pyrene-derived benzimidazole-linked polymers to CO <sub>2</sub> separation under pressure and vacuum swing...
Binding of isomers of benzo[a]pyrene diol-epoxide to chromatin<...
Binding of Metabolically Activated Benzo(A)Pyrene to Nuclear Macromolecules<...
Mutagenesis and carcinogenesis induced by dibenzo[a,l]pyrene in the mouse oral cavity: A potential new model for oral cancer<...
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Mechanism of benzo[a]pyrene-induced Cyp1a-1 gene expression in mouse Hepa 1c1c7 cells: Role of the nuclear 6 s and 4 s proteins...
Roberts Stochastic thoughts: 4/1/08 - 5/1/08
Advertisement In utero Exposure of Mice to Dibenzo[a,l]Pyrene Produces Lymphoma in the Offspring: Role of the Aryl Hydrocarbon...
Carcinogenicity of benzo-ring derivatives of benzo(a)pyrene on mouse s by W Levin, A W. Wood et al.
Enzyme immunoassay of benzo[a]pyrene conjugated to DNA, RNA and microsomal proteins using a monoclonal antibody. - Semantic...
192-97-2, benzo[e]pyrene, CAS No 192-97-2 benzo[e]pyrene nl
Benzo[e]pyrene | CAS: 192-97-2 | Benzo[e]pyrene Supplier
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PQR | 9-(2-deoxy-5-o-phosphonopentofuranosyl)-n-(7,8,9-trihydroxy-7,8,9,10-tetrahydrobenzo[pqr]tetraphen-10-yl)-9h-purin-6-amine
DIBENZO[A,E]PYRENE UNLABELED - Creative Proteomics
Influence of combined deficiency of fat and vitamin A on benzo(a)pyrene-induced lung carcinogenesis in rats. - Semantic Scholar
Formation of glucuronide, sulphate and glutathione conjugates of benzo by J Zaleski, S K. Bansal et al.
Dibenzo[b,e]Thiepin-11(6H)-One 1531-77-7 MSDS, Safety Technical Specifications MSDS
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Phenylethynyl-pyrene (PEP) in Fluorophores
Trichloroepoxypropane
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Benzo(a)pyrene
"Benzopyrene and Vitamin A deficiency". Researcher links cigarettes, vitamin A and emphysema. Retrieved March 5, 2005.. ... "Levels of Benzopyrene in Burnt toasts". Guardian Unlimited, Special reports: Close encounters. Retrieved March 5, 2005.. ... The substance with the formula C20H12 is one of the benzopyrenes, formed by a benzene ring fused to pyrene. Its diol epoxide ... The compound is one of the benzopyrenes, formed by a benzene ring fused to pyrene, and is the result of incomplete combustion ...
Benzo(a)pyrene
"Benzopyrene and Vitamin A deficiency". Researcher links cigarettes, vitamin A and emphysema. Retrieved March 5, 2005.. ... 3,4-benzopyrene. 3,4-benz[a]pyrene. 3,4-benzo[a]pyrene. pentacyclo[10.6.2.02,7.09,19.016,20]icosa-1,3,5,7,9,11,13,15,17,19- ... "Levels of Benzopyrene in Burnt toasts". Guardian Unlimited, Special reports: Close encounters. Retrieved March 5, 2005.. ... The substance with the formula C20H12 is one of the benzopyrenes, formed by a benzene ring fused to pyrene. Its diol epoxide ...
Benzo(a)pyrene
Benzopyrene Benzo[e]pyrene Pyrene, a four-ring analogue Toxification Henri A. Favre, Warren H. Powell (2013). Nomenclature of ... The substance with the formula C20H12 is one of the benzopyrenes, formed by a benzene ring fused to pyrene. Its diol epoxide ... The compound is one of the benzopyrenes, formed by a benzene ring fused to pyrene, and is the result of incomplete combustion ... "Levels of Benzopyrene in Burnt toasts". Guardian Unlimited, Special reports: Close encounters. Retrieved March 5, 2005. Karle, ...
Health effects of tobacco
Benzopyrene diol epoxide, an extremely carcinogenic (cancer-causing) metabolite of benzopyrene, a polycyclic aromatic ... "DNA interaction with Benzopyrene". DNA. Archived from the original on December 23, 2004. Retrieved March 5, 2005.. ... The first PAH to be identified as a carcinogen in tobacco smoke was benzopyrene, which has been shown to toxicate into an ... Benzopyrene, a major mutagen in tobacco smoke, in an adduct to DNA[161] ...
Benzo(a)pyren - Wikipedie
V tomto článku byl použit překlad textu z článku Benzopyrene na anglické Wikipedii. ... Lung cancer as consequence by Benzopyrene in smokers [online]. [cit. 2005-03-05]. (Lung Cancer). Dostupné v archivu pořízeném ... Levels of Benzopyrene in Burnt toasts [online]. [cit. 2005-03-05]. (Guardian Unlimited). Dostupné online.. ... DNA interaction with Benzopyrene [online]. [cit. 2005-03-05]. (DNA). Dostupné online.. ...
Charcoal biscuit
Food portal Activated charcoal Benzopyrene Disley, John (2006). CharcoalRemedies.com. Remnant Publications. ISBN 978-0-9738464- ...
Particulates
These soot particles also carry carcinogens like benzopyrenes adsorbed on their surface. Particulate mass is not a proper ...
Russian embargo of Ukrainian goods
29 July 2013). Kazakhstan did not find benzopyrene in the Roshen products. Ukrainian National News. (5 August 2013). Kyrgyzstan ...
Pacific Gas and Electric Company
4-benzopyrene and potassium chromate in mice drink". Arch Hyg Bakteriol. Carcinogens in water and soil. 152 (XXII): 45-53. ...
Hinkley groundwater contamination
4-benzopyrene and potassium chromate in mice drink". Arch Hyg Bakteriol. Carcinogens in water and soil. 152 (XXII): 45-53. PMID ...
Ostrava
Air condition in Ostrava is currently very poor, with high concentrations of benzopyrene. The pollution is so serious that it ... Measurements performed by the Czech Hydrometeorological Institute show that levels of atmospheric benzopyrene and dust ...
Benzo(e)pyrene
Benzopyrene Benzo[a]pyrene Benzene Pyrene, a four-ring analogue v t e. ...
Arene oxide
Benzopyrene is also converted to an epoxide, (+)-benzo[a]pyrene-7,8-epoxide. Benzene oxide (C6H6O) exists as an equilibrium ...
Jacques Miller
Miller, JF (1963). "Effect of thymectomy on the induction of skin tumours by 3,4-benzopyrene". Nature. 199 (4896): 920-2. ...
Epoxide
For prochiral arenes (naphthalene, toluene, benzoates, benzopyrene), the epoxides are often obtained in high enantioselectivity ...
Yeosuana
... aromativorans is a species of non-motile aerobic marine bacterium that can degrade benzopyrene. It was first isolated ...
Delitti e profumi
... benzopyrene-15). Eddy decides to find if there was a connection between the two victims and he discovers that each victim had ...
Tobacco marketing targeting African Americans
Brown began by explaining the ingredient menthol contains compounds such as benzopyrene, which is carcinogenic when smoked. He ...
Occupational cardiovascular disease
Associations also exist for exposure to arsenic, benzopyrenes, lead, dynamite, carbon disulphide, carbon monoxide, metalworking ...
Chemical hazard
Associations also exist for exposure to arsenic, benzopyrenes, lead, dynamite, carbon disulphide, carbon monoxide, metalworking ...
Del Amo (Superfund site)
... benzopyrene, phenanthrene and chrysene. Benzene is known to be a human carcinogen, and is detected most frequently and at the ...
Food safety incidents in Taiwan
They also tested the tainted oil for any heavy metals, aflatoxin and benzopyrene, which may cause cancer in humans. However, ...
Heterocyclic amine formation in meat
Most of the 20 HCAs are more toxic than benzopyrene, a carcinogen found in cigarette smoke and coal tar. MeIQ, IQ and 8-MeIQx ...
Ernst Wynder
Wynder also discovered specific carcinogens in tar (e.g., benzopyrenes, arsenic), but was unable to identify the contributions ...
Pyrene
Although it is not as problematic as benzopyrene, animal studies have shown pyrene is toxic to the kidneys and liver. It is now ...
Oil well fire
Smoke from burnt crude oil contains many chemicals, including sulfur dioxide, carbon monoxide, soot, benzopyrene, Poly aromatic ...
Smoker's melanosis
Smoking or the use of nicotine-containing drugs is the cause to Smoker's melanosis,. Also tar-components (benzopyrenes) are ...
FAM185A
... and benzopyrene. These interactions are not yet confirmed for the human protein, FAM185A. Currently, no diseases are known to ...
Smoking ban
Sidestream smoke contains 69 known carcinogens, particularly benzopyrene and other polynuclear aromatic hydrocarbons, and ...
Mycobacterium vanbaalenii
3-methylcholanthrene and benzopyrene. First isolated from an environmental source, not known to be pathogenic. Strain PYR-1 = ...
Benzopyrene - Wikipedia
A benzopyrene is an organic compound with the formula C20H12. Structurally speaking, the colorless isomers of benzopyrene are ... Benzopyrene is a component of pitch and occurs together with other related pentacyclic aromatic species such as picene, ... Two isomeric species of benzopyrene are benzo[a]pyrene and the less common benzo[e]pyrene. They belong to the chemical class of ... Benzopyrenes are harmful because they form carcinogenic and mutagenic metabolites (such as (+)-benzo[a]pyrene-7,8-dihydrodiol-9 ...
Benzopyrene dictionary definition | benzopyrene defined
and known to be a cause of cancer in animalssometimes called benz·py′rene Origin of benzopyrene benzo- + pyrene... ... benzopyrene definition: an aromatic hydrocarbon, CH, found in coal tar, cigarette smoke, etc. ... benzopyrene. ben·zo·py·rene. an aromatic hydrocarbon, CH, found in coal tar, cigarette smoke, etc. and known to be a cause of ... benzopyrene. noun. Either of two polycyclic aromatic hydrocarbons with the formula C20H12, found in coal tar and cigarette ...
Brazilian scientists examine how benzopyrene can cause cancer
Canary Database: Browse by Exposure: Benzopyrenes
Polycyclic Aromatic Hydrocarbons - Compounds, Benzo, Organic, and Benzopyrene
- JRank Articles
Benzopyrene, for example, is an organic chemical with the general formula C20H12, containing a five-ring structure. Benzopyrene ... Some of the better known polycyclic aromatic compounds in environmental chemistry include anthracene, benzopyrene, ... There are various isomers, or structural variants of benzopyrene which differ greatly in their toxicological properties. The ...
benzopyrene: Topics by WorldWideScience.org
Benzopyrene monooxygenase (BPMO) values also seem to confirm such chemical stress. High levels of Hg and largely accumulated ... The main PAH, which cumulates in the organism is benzopyrene. This substance has been described by the IARC as a the most ... PBMC cells exposed to either benzopyrene (1 μM) or silymarin (2.4 mg/ml) or both was monitored for toxicity by assessing LPO, ... C) Benzopyrene, Vesselinovitch et al., 1975: Hepatic tumor incidence after single, parenteral administration to rats: - at day ...
RCSB PDB - 2IA6: Bypass of Major Benzopyrene-dG Adduct by Y-Family DNA Polymerase with Unique Structural Gap
benzopyrene | Definition of benzopyrene in US English by Oxford Dictionaries
Definition of benzopyrene in US English - a compound that is the major carcinogen present in cigarette smoke. It also occurs in ... Burnt toast (and, for that matter, barbecued or smoked meats) contains increased levels of a known carcinogen, benzopyrene. ... Wood fires can also release benzopyrene, a carcinogen that can irritate your eyes, nose, throat, and lungs. ... he admitted that the examination of the controversial benzopyrene is not included in the normal importation inspection. ...
Field evaluation of benzopyrene hydroxylase induction as a monitor for marine petroleum pollution | Science
Field evaluation of benzopyrene hydroxylase induction as a monitor for marine petroleum pollution ... Field evaluation of benzopyrene hydroxylase induction as a monitor for marine petroleum pollution ... Field evaluation of benzopyrene hydroxylase induction as a monitor for marine petroleum pollution ... Field evaluation of benzopyrene hydroxylase induction as a monitor for marine petroleum pollution ...
Benzo pyrene-induced DNA adducts and gene expression profiles in target and non-target organs for carcinogenesis in mice. | MRC
How benzopyrene in Latvian sprats leads to Russophobia
NIOSHTIC-2 Publications Search - 20041454 - Detection of polycyclic aromatic hydrocarbons (PAHS) in skin wipe samples of...
NIOSHTIC-2 Publications Search - 20023853 - Biological monitoring for exposure to coal tar.
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Cyclobenzaprine - do this medication cause to to have a positive drug test?
Benzo(a)pyrene - Wikipedia
"Benzopyrene and Vitamin A deficiency". Researcher links cigarettes, vitamin A and emphysema. Retrieved March 5, 2005.. ... "Levels of Benzopyrene in Burnt toasts". Guardian Unlimited, Special reports: Close encounters. Retrieved March 5, 2005.. ... The substance with the formula C20H12 is one of the benzopyrenes, formed by a benzene ring fused to pyrene. Its diol epoxide ... The compound is one of the benzopyrenes, formed by a benzene ring fused to pyrene, and is the result of incomplete combustion ...
Benzo(a)pyrene - Wikipedia
"Benzopyrene and Vitamin A deficiency". Researcher links cigarettes, vitamin A and emphysema. Retrieved March 5, 2005.. ... 3,4-benzopyrene. 3,4-benz[a]pyrene. 3,4-benzo[a]pyrene. pentacyclo[10.6.2.02,7.09,19.016,20]icosa-1,3,5,7,9,11,13,15,17,19- ... "Levels of Benzopyrene in Burnt toasts". Guardian Unlimited, Special reports: Close encounters. Retrieved March 5, 2005.. ... The substance with the formula C20H12 is one of the benzopyrenes, formed by a benzene ring fused to pyrene. Its diol epoxide ...
Category:Polycyclic aromatic hydrocarbons - Wikimedia Commons
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The EPA National Library Catalog | EPA National Library Network | US EPA
Mitochondrial DNA is a major cellular target for a dihydrodiol-epoxide derivative of benzo[a]pyrene
Sampling and Analytical Methods | Coal Tar Pitch Volatiles (CTPV), 58
OSHA Chemical Database | Occupational Safety and Health Administration
Substance Priority List | ATSDR
2013 ATSDR Substance Priority List | Substance Priority List | ATSDR
Profiling of Biomarkers for the Exposure of Polycyclic Aromatic Hydrocarbons: Lamin-A/C Isoform 3, Poly[ADP-ribose] Polymerase...
... including curved backbone and cardiomegaly in zebrafish were observed in the 54 hpf with more than 400 nM of benzopyrene. In ... lamin-A/C isoform 3 and annexin A1 for benzopyrene; lamin-A/C isoform 3 and DNA topoisomerase 2-alpha for pentacene; poly[ADP- ... Benzopyrene (BaP) among 32 PAH compounds is notable for being the first chemical carcinogen to be discovered [2, 3]. ... DMSO, only DMSO-treatment as control; PARP-1, poly[ADP-ribose] polymerase 1; LMNA, lamin A/C; BaP, benzopyrene.. ...
Inhibition of benzo pyrene- and cyclophosphamide-induced mutagenicity by Cinnamomum cassia - ABIM - An Annotated Bibliography...
Antibodies against homogeneous epoxide hydratase provide evidence for a single enzyme hydrating styrene oxide and benz(a)pyrene...
The frequency of polychromatic erythrocytes (PE) in the relation with erythrocytes normochromic (NE) in rats (R) treated whit...
Benzo[a]pyrene
Benzo2
- Two isomeric species of benzopyrene are benzo[a]pyrene and the less common benzo[e]pyrene. (wikipedia.org)
- Benzopyrenes are harmful because they form carcinogenic and mutagenic metabolites (such as (+)-benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide from benzo[a]pyrene) which intercalate into DNA, interfering with transcription. (wikipedia.org)
Polycyclic aromatic hyd1
- In February 2014, NASA announced a greatly upgraded database for tracking polycyclic aromatic hydrocarbons (PAHs), including benzopyrene, in the universe. (wikipedia.org)
Pyrene3
- Structurally speaking, the colorless isomers of benzopyrene are pentacyclic hydrocarbons and are fusion products of pyrene and a phenylene group. (wikipedia.org)
- The substance with the formula C 20 H 12 is one of the benzopyrenes , formed by a benzene ring fused to pyrene . (wikipedia.org)
- The compound is one of the benzopyrenes , formed by a benzene ring fused to pyrene , and is the result of incomplete combustion at temperatures between 300 °C (572 °F) and 600 °C (1,112 °F). (wikipedia.org)
Compounds5
- Benzopyrene (BaP) among 32 PAH compounds is notable for being the first chemical carcinogen to be discovered [ 2 , 3 ]. (hindawi.com)
- They may also inhibit the binding of nucleic acids to benzopyrenes and related compounds. (harvard.edu)
- Cooking food at temperatures over 180ºC promotes formation of several carcinogenic compounds, including aromatic hydrocarbon, benzopyrene, and heterocyclic amine (HCA). (mercola.com)
- Exposure of food to high cooking temperatures (over 180ºC) such as with oven roasting or frying can lead to the formation of toxic carcinogenic compounds which include aromatic hydrocarbon, benzopyrene and heterocyclic amine. (mercola.com)
- These are four volatile oil compounds that help neutralize the benzopyrenes found in cigarette smoke as well as in charcoal grill smoke. (hubpages.com)
Benzene1
- Benzopyrene is extremely insoluble in water but very soluble in certain organic solvents such as benzene. (jrank.org)
Carcinogenic2
- It also included benzopyrene, which smells nice but is highly carcinogenic. (gadling.com)
- G]inseng exhibited beneficial effects on the detoxification of a carcinogenic compound, benzopyrene. (quackwatch.org)
Isomers1
- There are various isomers, or structural variants of benzopyrene which differ greatly in their toxicological properties. (jrank.org)
Lung5
- Full Text Available This paper reports a screening results of the secondary metabolites composed in Spathodea campanulata Beauv stem bark, evaluate inhibiting activity of malondialdehyde (MDA on rat's cancer model exposed with benzopyrene , and the histology of its lung. (worldwidescience.org)
- The isolated fraction contained of these metabolites significantly indicate bioactivity by reducting of malondialdehyde (MDA level, and also histology appearance of the lung tissue prepared from the benzopyrene -exposed rat indicated a curative activity. (worldwidescience.org)
- Statistical eliminative process shows 3:4- benzopyrene (BP) to be the hydrocarbon of prime importance in lung cancer and bronchitis, with 1:12 benzoperylene contributing. (worldwidescience.org)
- Black tea polyphenols restrict benzopyrene-induced mouse lung cancer progression through inhibition of Cox-2 and induction of caspase-3 expression. (bvsalud.org)
- Furthermore, Zhao et al ( 16 ) demonstrated that benzopyrene (BaP) may promote lung cancer cell metastasis by activating the tumor necrosis factor-α signaling pathway. (spandidos-publications.com)
Antibody2
- A team led by Prof. Arne Skerra from the Technical University of Munich (TUM) has deciphered the binding mechanism of an antibody to benzopyrene - a discovery that could pave the way for an easier method to identify and, hence, remove the toxin. (tum.de)
- The antibody-based nanoprobe was used for in situ measurements of benzopyrene tetrol in single cells. (springer.com)
Benzanthracene1
- Using cell proliferation and apoptosis assays, it was demonstrated that benzopyrene (BaP) suppressed the proliferation of mLFCs, and benzanthracene (BaA) and BaP induced cell apoptosis. (spandidos-publications.com)
Mutagenic1
- Apparently, it was not in vain that the Russian sanitary inspectors at one time so advocated a ban on the Latvian canned product "Sprats in oil" due to the high content of benzopyrene in it, which causes mutagenic effects on the human body. (topwar.ru)
Coal1
- However, when fat reacts with glowing coal, a substance chemists call benzopyrene is created. (tum.de)
Organic3
- A benzopyrene is an organic compound with the formula C20H12. (wikipedia.org)
- Benzopyrene, for example, is an organic chemical with the general formula C 20 H 12 , containing a five-ring structure. (jrank.org)
- Other countries, such as Japan and the United States, did not set specific standards for benzopyrene in smoked fish products, but recommended its industries to voluntarily reduce the presence of the said organic compound to the lowest possible level," the statement read. (thepinoy.com)
Rats1
- The frequency of polychromatic erythrocytes (PE) in the relation with erythrocytes normochromic (NE) in rats (R) treated whit benzopyrene. (scholars.direct)
Liver1
- Fish from petroleum-contaminated sites in the marine environment have elevated levels of benzopyrene hydroxylase activity in liver and gill tissue. (sciencemag.org)
Neoplastic1
- Rights & permissions for article Metabolic degradation of 3,4-benzopyrene in the cultures of normal and neoplastic fibroblasts. (nature.com)
Charcoal1
- Fumes that develop from fat dripping on blistering charcoal are rich in benzopyrene, which can condense on grilled goods. (wikipedia.org)
Researchers1
- Researchers estimated that every day the average infant under the age of two in urban America ingested 110 nanograms of benzopyrene, equivalent to smoking three cigarettes a day. (oxforddictionaries.com)
Harmful1
- In a statement, it said KFDA had conducted a thorough test and issued a certificate on Nov. 7, 2012 saying that the level of benzopyrene found in the noodle powder-which ranges from 0.4 to 1.6 ppb-"was extremely low and has no harmful effect on the human body. (thepinoy.com)
Cells2
- Macrophages promote benzopyrene-induced tumor transformation of human bronchial epithelial cells by activation of NF-κB and STAT3 signaling in a bionic. (oncotarget.com)
- We investigated the role of macrophages in promoting benzopyrene (BaP)-induced malignant transformation of human bronchial epithelial cells using a BaP-induced tumor transformation model with a bionic airway chip in vitro and in animal models. (oncotarget.com)
Found1
- Tests of medications purchased online have found PCBs (polychlorinated biphenyls) and benzopyrenes in fake medication purchased for the tests. (safemedicines.org)
Animals1
- Animals in group A and group B were given 3,4- benzopyrene -corn oil mixture pulmonary injection fortnightly for 4 times, while in group C corn oil only. (worldwidescience.org)
Levels1
- Burnt toast (and, for that matter, barbecued or smoked meats) contains increased levels of a known carcinogen, benzopyrene. (oxforddictionaries.com)
Normal1
- Although legally imported olive oil has passed the required quarantine inspection, he admitted that the examination of the controversial benzopyrene is not included in the normal importation inspection. (oxforddictionaries.com)
Main1
- NER is the main mechanism used to remove pyrimidine dimers induced by UV cross-linking or chemical damage such as those caused by benzopyrene, aflatoxin, and cisplatin. (oxforddictionaries.com)
Drug1
- Would cyclobenzaprine test positive for a drug test as a benzopyrene? (drugs.com)