Benzopyrene Hydroxylase
Benzopyrenes
Nikethamide
Phenylalanine Hydroxylase
Steroid 21-Hydroxylase
An adrenal microsomal cytochrome P450 enzyme that catalyzes the 21-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP21 gene, converts progesterones to precursors of adrenal steroid hormones (CORTICOSTERONE; HYDROCORTISONE). Defects in CYP21 cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL).
Tryptophan Hydroxylase
Tyrosine 3-Monooxygenase
Mixed Function Oxygenases
Widely distributed enzymes that carry out oxidation-reduction reactions in which one atom of the oxygen molecule is incorporated into the organic substrate; the other oxygen atom is reduced and combined with hydrogen ions to form water. They are also known as monooxygenases or hydroxylases. These reactions require two substrates as reductants for each of the two oxygen atoms. There are different classes of monooxygenases depending on the type of hydrogen-providing cosubstrate (COENZYMES) required in the mixed-function oxidation.
Procollagen-Proline Dioxygenase
A mixed-function oxygenase that catalyzes the hydroxylation of a prolyl-glycyl containing peptide, usually in PROTOCOLLAGEN, to a hydroxyprolylglycyl-containing-peptide. The enzyme utilizes molecular OXYGEN with a concomitant oxidative decarboxylation of 2-oxoglutarate to SUCCINATE. The enzyme occurs as a tetramer of two alpha and two beta subunits. The beta subunit of procollagen-proline dioxygenase is identical to the enzyme PROTEIN DISULFIDE-ISOMERASES.
Benzoflavones
Organic compounds containing a BENZENE ring attached to a flavone group. Some of these are potent arylhydrocarbon hydroxylase inhibitors. They may also inhibit the binding of NUCLEIC ACIDS to BENZOPYRENES and related compounds. The designation includes all isomers; the 7,8-isomer is most frequently encountered.
Benzene
Toxic, volatile, flammable liquid hydrocarbon byproduct of coal distillation. It is used as an industrial solvent in paints, varnishes, lacquer thinners, gasoline, etc. Benzene causes central nervous system damage acutely and bone marrow damage chronically and is carcinogenic. It was formerly used as parasiticide.
Receptors, Aryl Hydrocarbon
Cytoplasmic proteins that bind certain aryl hydrocarbons, translocate to the nucleus, and activate transcription of particular DNA segments. AH receptors are identified by their high-affinity binding to several carcinogenic or teratogenic environmental chemicals including polycyclic aromatic hydrocarbons found in cigarette smoke and smog, heterocyclic amines found in cooked foods, and halogenated hydrocarbons including dioxins and polychlorinated biphenyls. No endogenous ligand has been identified, but an unknown natural messenger with a role in cell differentiation and development is suspected.
Tetrachlorodibenzodioxin
Xenobiotics
Cytochrome P-450 CYP1A1
A liver microsomal cytochrome P-450 monooxygenase capable of biotransforming xenobiotics such as polycyclic hydrocarbons and halogenated aromatic hydrocarbons into carcinogenic or mutagenic compounds. They have been found in mammals and fish. This enzyme, encoded by CYP1A1 gene, can be measured by using ethoxyresorufin as a substrate for the ethoxyresorufin O-deethylase activity.
Neoplasms
Tobacco
Bixaceae
Cytochrome P-450 Enzyme System
A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.
Metyrapone
Steroids
A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)
Inhibition of benzo(alpha)pyrene metabolism catalyzed by mouse and hamster lung microsomes. (1/54)
Induced and constitutive microsomal enzymes of mouse and hamster lungs catalyze both the hydroxylation of benzo(alpha)pyrene and reactions that lead to its irreversible binding to macromolecules. For mouse and hamster, the induced lung hydroxylases have Km values of 1.10 and 0.52 muM, respectively. The induced hydroxylases are strongly inhibited by 7,8-benzoflavone and are stimulated by cyclohexene oxide, an inhibitor of epoxide hydrase. Formation of the macromolecular product by the induced "binding" enzyme follows. Michaelis-Menten kinetics, except for substrate inhibition, and has Km values of 0.52 and 0.25 muM for lung microsomes from mouse and hamster, respectively. These reactions are also inhibited by 7,8-benzoflavone. The reaction catalyzed by the constitutive hydroxylase of mouse lungs is characterized by a brief lag period but proceeds in a linear fashion after the lag. The enzyme requires 60 muM benzo(alpha)pyrene to achieve maximum reaction velocity. Above this concentration, strong substrate inhibition is observed; accurate values for Vmax and Km cannot be derived. The constitutive hydroxylases are moderately inhibited by butylated hydroxytoluene, retinol, cyclohexene oxide, and 7,8-benzoflavone. The product of the constitutive "binding" enzyme is formed in a reaction that follows Michaelis-Menten kinetics. The Km value for enzymes from mouse and hamster lungs are 11.8 and 4.9 muM, respectively. Formation of this product is strongly inhibited by butylated hydroxytoluene and by retinol but not strongly by 7,8-benzoflavone or cyclohexene oxide. Since other evidence indicates that a constitutive enzyme may be involved in carcinogenesis by benzo(alpha)pyrene and since this reaction is inhibited by two known anticarcinogens, we suggest that it may be involved in this process. (+info)The atherogen 3-methylcholanthrene induces multiple DNA adducts in mouse aortic smooth muscle cells: role of cytochrome P4501B1. (2/54)
OBJECTIVE: 3-Methylcholanthrene (MC), a polycylic aromatic hydrocarbon, induces atherogenesis in mice fed an atherogenic diet. In this study, we tested the hypothesis that MC would induce DNA adducts in mouse aortic smooth muscle cells (SMCs) and that cytochrome P4501B1 (CYP1B1) plays an important role in the activation of MC to genotoxic intermediates. METHODS: Cultured SMCs were treated with MC or the vehicle dimethyl sulfoxide (DMSO), and DNA was isolated after 24 h. In some experiments, the cells were pre-treated with the CYP1B1 inhibitor 1-ethynylpyrene (EP) prior to exposure to MC. DNA adducts were determined by the 32P-postlabeling assay. Aryl hydrocarbon hydroxylase assay was measured by fluorimetry. RESULTS: MC induced formation of 12 DNA adducts that were not observed in DMSO-treated cells. DNA adduct formation was dose-dependent, with maximum response observed at 3 microM. Pre-treatment of cells with EP dramatically suppressed DNA adduct formation by MC. MC treatment caused induction of CYP1B1, but not CYP1A1. CONCLUSION: The induction of high levels of multiple DNA adducts in SMCs by MC suggests that SMCs have a functional enzymatic machinery capable of metabolically activating MC to genotoxic metabolites. The significant inhibition by EP of MC-induced DNA adduct formation indicated that CYP1B1 was the primary CYP enzyme responsible for formation of genotoxic metabolites that may play a role in the induction of atherosclerosis by MC. (+info)Development of an assay for aryl hydrocarbon (benzo(a)pyrene) hydroxylase in human peripheral blood monocytes. (3/54)
An assay has been developed and measurements of aryl hydrocarbon [benzo(a)pyrene] hydroxylase have been made in peripheral blood monocytes from a human population. Treatment with benz(a)anthracene in cell culture increased aryl hydrocarbon hydroxylase activity from 6.5 to 37-fold in monocytes from each of 25 apparently healthy donors. A weak correlation (r = 0.38) was observed between the induction ratios obtained with monocytes and lymphocytes from the same donors. Reproducibilities of the monocyte and lymphocyte assays were comparable. In monocytes, the measurement of basal and induced aryl hydrocarbon hydroxylases activity does not require pretreatment with mitogens as is the case with lymphocytes. Monocytes also exhibit a much wider range of induction ratios than do lymphocytes. (+info)Mechanism of dioxin action: Ah receptor-mediated increase in promoter accessibility in vivo. (4/54)
We have analyzed dioxin-inducible, Ah receptor-dependent changes in protein-DNA interactions at the CYP1A1 transcriptional promoter in intact mouse hepatoma cells. Our findings indicate that in uninduced cells, the promoter is inaccessible to its cognate binding proteins, which are known to be expressed constitutively. Dioxin induces, in Ah receptor-dependent fashion, an increase in promoter accessibility, which occurs rapidly and does not require ongoing transcription of the CYP1A1 gene. The change in promoter accessibility is not due to an altered pattern of cytosine methylation at the promoter; it probably reflects a 2,3,7,8-tetrachlorodibenzo-p-dioxin- induced change in the chromatin structure. These findings provide new insight into the mechanism of dioxin action and contribute to a better understanding of the regulation of inducible gene transcription in mammalian cells. (+info)Regulation of aryl hydrocarbon (benzo-(A)-pyrene) hydroxylase activity in mammalian cells. Induction of hydroxylase activity by N6,O2'-dibutyryl8 adenosine 3':5'-monophosphate and aminophylline. (5/54)
Treatment of hamster BHK cells with N6,O2'-dibutyryl adenosine 3':5'-monophosphate (Bt2cAMP), aminophylline, theophylline, or papaverine increased the level of aryl hydrocarbon (benzo(a)pyrene) hydrolxylase activity. The highese increase, 100-fold, was obtained with Bt2cAMP plus aminophylline or theophylline. N2,O2-Dibutyryl guanosine 3':5'-monophosphate gave a lower induction than Bt2cAMP. The level of hydroxylase activity started to decrease 6 hours after treatment with the inducer and was reduced to almost the uninduced level after 24 hours. Repeated addition of Bt2cAMP and aminophylline did not prevent this decrease. The hydroxylase can also be induced by treating cells with benz(a)anthracene, and the level of this induced activity was maintained for 24 hours. Aminophylline gave a 2- to 8-fold stimulation of the induction by benz(a)anthracene. The enzyme activity induced by Bt2cAMP, aminophylline, and benz(a)anthracene converted benzo(a)pyrene to similar alkali-extractable metabolities with a fluorescence spectra similar to that of 3-hydroxybenzo(a)pyrene. These induced enzyme activities also showed a similar heat stability. Induction by Bt2cAMP and aminophylline, like induction by benz(a)anthracene, required continued protein synthesis and only an initial period of RNA synthesis. Compared to the benz(a)anthracene-induced hydroxylase with a Km of 4.3 muM, the hydroxylase induced by Bt2cAMP and aminophylline showed a Km of 0.14 muM, and was 100-fold more sensitive to inhibition by 7,8-benzoflavone. Increasing the serum concentration in the culture medium stimulated the induction by aminophylline but did not stimulate induction by benz(a)anthracene. The results indicate that aryl hydrocaarbon (benzo(a)pyrene) hydroxylase can be induced by compounds that increase the level of adenosine 3':5'-monophosphate and that this induction and induced enzyme activity differs from that caused by benz(a)anthracene. (+info)Activation of 3':5'-cyclic AMP-dependent protein kinase and induction of ornithine decarboxylase as early events in induction of mixed-function oxygenases. (6/54)
The parenteral administration of a single dose of 3-methylcholanthrene to rats caused an increase in the liver of the concentration of 3', 5'-cAMP and of the activity of cAMP-dependent protein kinase (ATP:protein phosphotransferase, EC 2.7.1.37). These events were followed by an increased activity of ornithine decarboxylase (L-ornithine carboxy-lase, EC 4.1.1.17), the enzyme that controls the biosynthesis of polyamines. Finally, the activity of benzo[a]pyrene hydroxylase, as well as the amount of cytochrome P-448, was increased. Similarly, after the administration of phenobarbital, there was first an increase in the cAMP concentration and in the activity of cAMP-dependent protein kinase, then the induction of ornithine decarboxylase, and finally, an enhanced activity of ethylmorphine N-demethylase and an increased content of cytochrome P-450. These data suggest that the drug-induced processes in liver that increase the activities of the oxidative, and presumably other, drug-metabolizing enzymes include the following sequence of events: (1) increase in cAMP concentration and/or activation of cAMP-dependent protein kinase; (2) induction of ornithine decarboxylase; and, (3) induction of drug-metabolizing enzymes. (+info)NADH-dependent aryl hydrocarbon hydroxylase in rat liver mitochondrial outer membrane. (7/54)
NADH-dependent 3,4-benzpyrene hydroxylase activity was detected in the purified mitochondrial outer membrane fraction from the livers of rats treated with 3-methylcholanthrene. The specific activity in the outer membrane fraction is nearly equal to that of microsomes, a level too high to be accounted for only by the microsomal contamination. On the other hand, the NADPH-dependent 3,4-benzpyrene hydroxylase activity in the outer membrane fraction is about 50% of that of microsomes. The ratio of the specific activity of NADPH- to NADH-dependent 3,4-benzpyrene hydroxylase in microsomal fraction was about 3.5, while that of the outer membrane fraction was about 1.5. Moreover, it was found that NADH-dependent 3,4-benzpyrene hydroxylase activity in mitochondrial outer membrane from control rat liver was cyanide-insensitive, while that in microsomes was cyanide-sensitive. These results suggest the presence in the mitochondrial outer membrane fraction of aryl hydrocarbon hydroxylase activity which uses as electron donor NADH nearly to the same extent as NADPH. The hydroxylase system is composed of cyanide-insensitive cytochrome P-450 and is inducible markedly by 3-methylcholanthrene treatment. The probable electron transfer pathways in the mitochondrial outer membrane cytochrome P-450 oxidase system are discussed. (+info)A relative deficiency of cytochrome P-450 and aryl hydrocarbon [benzo(a)pyrene] hydroxylase in hyperplastic nodules induced by 2-acetylaminofluorene in rat liver. (8/54)
The concentrations of cytochrome P-450 and the activities of aryl hydrocarbon [benzo(a)pyrene] hydroxylase (AHH) and reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase were measured in early (gray-white) and remodeled (brown) hyperplastic nodules induced in the livers of rats with 2-acetylaminofluorene and were compared to the values in control livers and in the liver surrounding the nodules. Cytochrome P-450 content of early (14 weeks) hyperplastic nodules is 30% of the activity of untreated control livers and 48% of the activity of the surrounding liver. AHH activity of the early nodules is 10% of the control activity and 33% of the activity in the surrounding nonnodular liver. Nicotinamide adenine dinucleotide phosphate-cytochrome c reductase activity in the microsomes of early nodules is 76% of the control activity and 78% of the activity in the surrounding liver. In the late remodeled nodules, (22 and 25 weeks), the cytochrome P-450 content is 40% of that of controls and AHH activity is 15% of the control activity. In primary hepatomas induced by 2-acetylaminofluorene, cytochrome P-450 content is 21% of that of controls, AHH activity is 11% of the activity of controls, and reductase is 50% of the control activity. These results, indicating a relative nodule deficiency in some of the cellular components believed to be important in the activation of hepatocarcinogens and hepatotoxins, offer one possible explanation for the relative resistance to carcinogen cytotoxicity of hyperplastic liver nodules. (+info)
Inhibition of highly purified benzo[α]pyrene hydroxylase from Saccharomyces cerevisiae by cytochrome P-448 binding compounds...
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Chemical Summary for Aldrin
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List of MeSH codes (D12.776)
... aniline hydroxylase MeSH D12.776.422.220.453.040.110 - benzopyrene hydroxylase MeSH D12.776.422.220.453.040.332 - cytochrome p- ... steroid 11-beta-hydroxylase MeSH D12.776.422.220.453.915.730 - steroid 12-alpha-hydroxylase MeSH D12.776.422.220.453.915.737 - ... steroid 16-alpha-hydroxylase MeSH D12.776.422.220.453.915.748 - steroid 17-alpha-hydroxylase MeSH D12.776.422.220.453.915.760 ... cholesterol 7 alpha-hydroxylase MeSH D12.776.422.220.453.915.212 - cholesterol side-chain cleavage enzyme MeSH D12.776.422.220. ...
List of MeSH codes (D08)
... aryl hydrocarbon hydroxylases MeSH D08.244.453.040.050 - aniline hydroxylase MeSH D08.244.453.040.110 - benzopyrene hydroxylase ... aniline hydroxylase MeSH D08.811.682.690.708.170.040.110 - benzopyrene hydroxylase MeSH D08.811.682.690.708.170.040.332 - ... steroid 11-beta-hydroxylase MeSH D08.244.453.915.730 - steroid 12-alpha-hydroxylase MeSH D08.244.453.915.737 - steroid 16-alpha ... hydroxylase MeSH D08.244.453.915.748 - steroid 17-alpha-hydroxylase MeSH D08.244.453.915.760 - steroid 21-hydroxylase MeSH ...
Field evaluation of benzopyrene hydroxylase induction as a monitor for marine petroleum pollution | Science
Field evaluation of benzopyrene hydroxylase induction as a monitor for marine petroleum pollution ... Field evaluation of benzopyrene hydroxylase induction as a monitor for marine petroleum pollution ... Field evaluation of benzopyrene hydroxylase induction as a monitor for marine petroleum pollution ... Field evaluation of benzopyrene hydroxylase induction as a monitor for marine petroleum pollution ...
Comparative metabolism of benzo[a]pyrene and drugs in human liver
Inhibition of human cytochrome p450 1b1 further clarifies its role in the activation of dibenzo[a,l]pyrene in cells in culture
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List of MeSH codes (D12.776) - Wikipedia
... aniline hydroxylase MeSH D12.776.422.220.453.040.110 - benzopyrene hydroxylase MeSH D12.776.422.220.453.040.332 - cytochrome p- ... steroid 11-beta-hydroxylase MeSH D12.776.422.220.453.915.730 - steroid 12-alpha-hydroxylase MeSH D12.776.422.220.453.915.737 - ... steroid 16-alpha-hydroxylase MeSH D12.776.422.220.453.915.748 - steroid 17-alpha-hydroxylase MeSH D12.776.422.220.453.915.760 ... cholesterol 7 alpha-hydroxylase MeSH D12.776.422.220.453.915.212 - cholesterol side-chain cleavage enzyme MeSH D12.776.422.220. ...
List of MeSH codes (D08) - Wikipedia
... aryl hydrocarbon hydroxylases MeSH D08.244.453.040.050 - aniline hydroxylase MeSH D08.244.453.040.110 - benzopyrene hydroxylase ... aniline hydroxylase MeSH D08.811.682.690.708.170.040.110 - benzopyrene hydroxylase MeSH D08.811.682.690.708.170.040.332 - ... steroid 11-beta-hydroxylase MeSH D08.244.453.915.730 - steroid 12-alpha-hydroxylase MeSH D08.244.453.915.737 - steroid 16-alpha ... hydroxylase MeSH D08.244.453.915.748 - steroid 17-alpha-hydroxylase MeSH D08.244.453.915.760 - steroid 21-hydroxylase MeSH ...
Alpha-Naphthoflavone: An Inhibitor of Hydrocarbon Cytotoxicity and Microsomal Hydroxylase | Science
Alpha-naphthoflavone inhibits the metabolism of 3,4-benzopyrene and 7,12-dimethylbenz(a)anthracene in hamster enlbryo cell ... Alpha-Naphthoflavone: An Inhibitor of Hydrocarbon Cytotoxicity and Microsomal Hydroxylase Message Subject. (Your Name) has ... Alphla-nalphthoflavone also inhibits the aryl hydrocarbon hydroxylase activity in homogenates of induced hamster embryo cells ...
benzopyrene: Topics by WorldWideScience.org
The polymorphisms most relevant to cancers induced by PIC exposures may be those of inductibility of benzopyrene hydroxylase, ... Benzopyrene monooxygenase (BPMO) values also seem to confirm such chemical stress. High levels of Hg and largely accumulated ... The main PAH, which cumulates in the organism is benzopyrene. This substance has been described by the IARC as a the most ... PBMC cells exposed to either benzopyrene (1 μM) or silymarin (2.4 mg/ml) or both was monitored for toxicity by assessing LPO, ...
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Identification of the human liver cytochrome P-450 guilty quest of coumarin 7-hydroxy-lase labour. Intrarenal fluoride ... An updated inspect of the clinical unfolding of coumarin (1,2-benzopyrene) and 7-hydroxycoumarin. Phenotypic and genotypic ... Immunochemical and catalytical studies on hepatic coumarin 7-hydroxylase in mankind, rat, and mouse. ...
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High levels of benzopyrene hydroxylase and folate receptors: benzopyrene, a carcinogen contained in various foods, is converted ... including the benzopyrene hydroxylase, that may protect them against food-derived carcinogens (Delaunoit 2005). ... to less toxic metabolites by the enzyme benzopyrene hydroxylase, which is present in much higher concentrations in the small ...
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Warning: 7,8-Benzoflavone Is Carcinogenic - World Class Bodybuilding Forum
They cant spell and seem to miss the point that 7,8 benzo is very different from benzopyrenes. October 8, 2009 2:09 PM ... Aryl Hydrocarbon Hydroxylase- and Polycyclic Hydrocarbon Tumorigenesis: Effect of the Enzyme Inhibitor 7,8-Benzoflavone on ... Benzopyrene - Wikipedia, the free encyclopedia. Proc. Nat. Acad. Sci. Vol. 69, No. 4, pp. 824-828, April 1972. ... 1. Hydrocarbon Hydroxylase- and Polycyclic Hydrocarbon Tumorigenesis: Effect of the Enzyme Inhibitor 7,8-Benzoflavone on ...
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Journal: Plant physiology / Publication Year: 1997 / Subject: dose response - PubAg Search Results
Competition between benzo[a]pyrene and various steroids for cytochrome P-450-dependent rat liver monooxygenases. - Pasleau...
... steroid-16 alpha-hydroxylase and aryl hydrocarbon hydroxylase (AHH). The results obtained suggest the following conclusions: (1 ... This paper describes the in vitro interaction between benzopyrene and steroids at the level of two rat liver monooxygenases: ... Steroid-16 alpha-hydroxylase is completely independent from cytochrome P1-450 (or P-448), as it is insensitive, in vitro, to ... Steroid-16 alpha-hydroxylase is partially supported by a specific cytochrome P-450 form which is not inhibited in vitro by ...
MH DELETED MN ADDED MN
Benzopyrene Hydroxylase D8.244.453.40.110 D8.244.453.05.110 D8.811.682.690.708.170.40.110 D8.811.682.690.708.170.10.110 D12.776 ... Aniline Hydroxylase D8.244.453.40.50 D8.244.453.05.50 D8.811.682.690.708.170.40.50 D8.811.682.690.708.170.10.50 D12.776.422.220 ... Vitamin D3 24-Hydroxylase D8.244.453.978 D8.244.453.496.500 D8.811.682.690.708.170.957 D8.811.682.690.708.170.469.500 D12.776. ... Aryl Hydrocarbon Hydroxylases D8.244.453.40 D8.244.453.05 D8.811.682.690.708.170.40 D8.811.682.690.708.170.10 D12.776.422.220. ...
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Conversely, toxaphene decreased the incidence of BP-induced tumors and inhibited BP hydroxylase activity in the lungs of the A/ ... Benzopyrene ; Oncogenesis ; Phosphorothiotic acid/O-O-(dimethyl-ester)-O-(nitrophenyl-ester) ... These results suggest that increased BP hydroxylase activity in tissues tends to enhance tumor formation and a decrease in the ... On the other hand, toxaphene enhanced benzo(a)pyrene (BP)-induced tumors and increased BP hydroxylase activity in the ...
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Carcinogens2
- Alpha-naphthoflavone inhibits the metabolism of 3,4-benzopyrene and 7,12-dimethylbenz(a)anthracene in hamster enlbryo cell cultures and protects the cells against the inhibition of cell multiplication by these carcinogens. (sciencemag.org)
- For instance, various indole compounds present in cruciferous vegetables activate the enzyme benzopyrene hydroxylase that degrades carcinogens. (journalofhealth.org)
Enzyme2
- Aryl Hydrocarbon Hydroxylase- and Polycyclic Hydrocarbon Tumorigenesis: Effect of the Enzyme Inhibitor 7,8-Benzoflavone on Tumorigenesis and Macromolecule Binding. (worldclassbodybuilding.com)
- These results suggest that increased BP hydroxylase activity in tissues tends to enhance tumor formation and a decrease in the enzyme activity may have a protective effect agains tumors. (epa.gov)
Tyrosine1
- The present study examines the time course of appearance of tyrosine hydroxylase (TH) immunoreactivity in the principal neurons and SIF cells of the rat sphenopalatine ganglion. (faintpower.gq)
Compounds2
- They may also inhibit the binding of nucleic acids to benzopyrenes and related compounds. (harvard.edu)
- Consistently the TMC 278 consultant compounds belonging to nicotine aromatic amines benzopyrene phenols aldehydes and some other volatile organics significantly and dose-dependently increased IL-8 levels in TMC 278 the culture supernatants of 16HBE cells among these compounds benzopyrene is a most potent stimulator for inducing IL-8 production. (elegantindulgence.net)
Metabolites2
- Full Text Available This paper reports a screening results of the secondary metabolites composed in Spathodea campanulata Beauv stem bark, evaluate inhibiting activity of malondialdehyde (MDA on rat's cancer model exposed with benzopyrene , and the histology of its lung. (worldwidescience.org)
- The isolated fraction contained of these metabolites significantly indicate bioactivity by reducting of malondialdehyde (MDA level, and also histology appearance of the lung tissue prepared from the benzopyrene -exposed rat indicated a curative activity. (worldwidescience.org)
Cytochrome3
- en] Cytochrome P-450-dependent monooxygenases are able to oxidize a large variety of endogenous and exogenous substrates. (uliege.be)
- The results obtained suggest the following conclusions: (1) Steroid-16 alpha-hydroxylase is partially supported by a specific cytochrome P-450 form which is not inhibited in vitro by exogenous substrates. (uliege.be)
- On stipulated day the animals were slaughtered, their livers taken out and microsomes prepared for the estimation of activities of various membrane bound DME such as cytochrome P450 (CP), cytochrome b5 (CB), cytochrome-c-reductase (CCR), aniline hydroxylase (AH), acetanilide hydroxylase (AAH), benzphetamine demethylase (BD), aminopyrine demethylase (APD), N. (thefreedictionary.com)
Potent1
- Some of these are potent arylhydrocarbon hydroxylase inhibitors. (harvard.edu)
Gill1
- Fish from petroleum-contaminated sites in the marine environment have elevated levels of benzopyrene hydroxylase activity in liver and gill tissue. (sciencemag.org)
Liver2
- Alphla-nalphthoflavone also inhibits the aryl hydrocarbon hydroxylase activity in homogenates of induced hamster embryo cells and in liver microsomes from rats previously treated with polycyclic aromatic hydrocarbons, but not in microsomes from control rats. (sciencemag.org)
- This paper describes the in vitro interaction between benzopyrene and steroids at the level of two rat liver monooxygenases: steroid-16 alpha-hydroxylase and aryl hydrocarbon hydroxylase (AHH). (uliege.be)
Activity2
- On the other hand, toxaphene enhanced benzo(a)pyrene (BP)-induced tumors and increased BP hydroxylase activity in the forestomach of the Ha/ICR mice and carbaryl enhanced BP-induced tumors and increased BP hydroxylase activity in the lungs of the A/J mice. (epa.gov)
- Conversely, toxaphene decreased the incidence of BP-induced tumors and inhibited BP hydroxylase activity in the lungs of the A/J mice. (epa.gov)
Group1
- Animals in group A and group B were given 3,4- benzopyrene -corn oil mixture pulmonary injection fortnightly for 4 times, while in group C corn oil only. (worldwidescience.org)