Bixaceae: A plant family of the order Violales, subclass Dilleniidae, class Magnoliopsida. Bixa contains bixin. Cochlospermum contains arjunolic acid and gum kondagogu (POLYSACCHARIDES).Cytochrome P-450 Enzyme System: A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.Steroids: A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)Benzoflavones: Organic compounds containing a BENZENE ring attached to a flavone group. Some of these are potent arylhydrocarbon hydroxylase inhibitors. They may also inhibit the binding of NUCLEIC ACIDS to BENZOPYRENES and related compounds. The designation includes all isomers; the 7,8-isomer is most frequently encountered.Methylcholanthrene: A carcinogen that is often used in experimental cancer studies.Benzopyrenes: A class of chemicals that contain an anthracene ring with a naphthalene ring attached to it.Benzopyrene Hydroxylase: A drug-metabolizing, cytochrome P-448 (P-450) enzyme which catalyzes the hydroxylation of benzopyrene to 3-hydroxybenzopyrene in the presence of reduced flavoprotein and molecular oxygen. Also acts on certain anthracene derivatives. An aspect of EC 1.14.14.1.Microsomes, Liver: Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. They may be smooth or rough.Benzo(a)pyrene: A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.Physicians: Individuals licensed to practice medicine.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Lawyers: Persons whose profession is to give legal advice and assistance to clients and represent them in legal matters. (American Heritage Dictionary, 3d ed)Child Advocacy: Promotion and protection of the rights of children; frequently through a legal process.Questionnaires: Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.Attitude of Health Personnel: Attitudes of personnel toward their patients, other professionals, toward the medical care system, etc.Bites, Human: Bites inflicted by humans.Physician-Patient Relations: The interactions between physician and patient.Information Services: Organized services to provide information on any questions an individual might have using databases and other sources. (From Random House Unabridged Dictionary, 2d ed)Ethics, Medical: The principles of professional conduct concerning the rights and duties of the physician, relations with patients and fellow practitioners, as well as actions of the physician in patient care and interpersonal relations with patient families.Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring.Dictionaries, MedicalCoal Tar: A by-product of the destructive distillation of coal used as a topical antieczematic. It is an antipruritic and keratoplastic agent used also in the treatment of psoriasis and other skin conditions. Occupational exposure to soots, tars, and certain mineral oils is known to be carcinogenic according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985) (Merck Index, 11th ed).Dictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.Ethers, Cyclic: Compounds of the general formula R-O-R arranged in a ring or crown formation.Khellin: A vasodilator that also has bronchodilatory action. It has been employed in the treatment of angina pectoris, in the treatment of asthma, and in conjunction with ultraviolet light A, has been tried in the treatment of vitiligo. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1024)Psoralea: A plant genus of the family FABACEAE that is a source of psoralen (FICUSIN).Dental Clasps: Metal devices for fastening together two or more parts of dental prostheses for stabilizing or retaining them by attachment to abutment teeth. For a precision attachment for a partial denture DENTURE PRECISION ATTACHMENT is available.Dictionaries, ChemicalAmiodarone: An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.Abbreviations as Topic: Shortened forms of written words or phrases used for brevity.Terminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.DictionaryNatural Language Processing: Computer processing of a language with rules that reflect and describe current usage rather than prescribed usage.Dictionaries, PharmaceuticDictionaries, DentalUnified Medical Language System: A research and development program initiated by the NATIONAL LIBRARY OF MEDICINE to build knowledge sources for the purpose of aiding the development of systems that help health professionals retrieve and integrate biomedical information. The knowledge sources can be used to link disparate information systems to overcome retrieval problems caused by differences in terminology and the scattering of relevant information across many databases. The three knowledge sources are the Metathesaurus, the Semantic Network, and the Specialist Lexicon.Receptors, CCR: Chemokine receptors that are specific for CC CHEMOKINES.Databases, Factual: Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.Chemokine CCL19: A CC-type chemokine with specificity for CCR7 RECEPTORS. It has activity towards T LYMPHOCYTES and B LYMPHOCYTES.Directories as Topic: Lists of persons or organizations, systematically arranged, usually in alphabetic or classed order, giving address, affiliations, etc., for individuals, and giving address, officers, functions, and similar data for organizations. (ALA Glossary of Library and Information Science, 1983)Trypanosoma brucei brucei: A hemoflagellate subspecies of parasitic protozoa that causes nagana in domestic and game animals in Africa. It apparently does not infect humans. It is transmitted by bites of tsetse flies (Glossina).Computer Communication Networks: A system containing any combination of computers, computer terminals, printers, audio or visual display devices, or telephones interconnected by telecommunications equipment or cables: used to transmit or receive information. (Random House Unabridged Dictionary, 2d ed)Semaphorin-3A: The prototypical and most well-studied member of the semaphorin family. Semaphorin-3A is an axon-repulsive guidance cue for migrating neurons in the developing nervous system. It has so far been found only in vertebrates, and binds to NEUROPILIN-1/plexin complex receptors on growth cones. Like other class 3 semaphorins, it is a secreted protein.Isochores: Large regions of the GENOME that contain local similarities in BASE COMPOSITION.Software: Sequential operating programs and data which instruct the functioning of a digital computer.

Inhibition of benzo(alpha)pyrene metabolism catalyzed by mouse and hamster lung microsomes. (1/54)

Induced and constitutive microsomal enzymes of mouse and hamster lungs catalyze both the hydroxylation of benzo(alpha)pyrene and reactions that lead to its irreversible binding to macromolecules. For mouse and hamster, the induced lung hydroxylases have Km values of 1.10 and 0.52 muM, respectively. The induced hydroxylases are strongly inhibited by 7,8-benzoflavone and are stimulated by cyclohexene oxide, an inhibitor of epoxide hydrase. Formation of the macromolecular product by the induced "binding" enzyme follows. Michaelis-Menten kinetics, except for substrate inhibition, and has Km values of 0.52 and 0.25 muM for lung microsomes from mouse and hamster, respectively. These reactions are also inhibited by 7,8-benzoflavone. The reaction catalyzed by the constitutive hydroxylase of mouse lungs is characterized by a brief lag period but proceeds in a linear fashion after the lag. The enzyme requires 60 muM benzo(alpha)pyrene to achieve maximum reaction velocity. Above this concentration, strong substrate inhibition is observed; accurate values for Vmax and Km cannot be derived. The constitutive hydroxylases are moderately inhibited by butylated hydroxytoluene, retinol, cyclohexene oxide, and 7,8-benzoflavone. The product of the constitutive "binding" enzyme is formed in a reaction that follows Michaelis-Menten kinetics. The Km value for enzymes from mouse and hamster lungs are 11.8 and 4.9 muM, respectively. Formation of this product is strongly inhibited by butylated hydroxytoluene and by retinol but not strongly by 7,8-benzoflavone or cyclohexene oxide. Since other evidence indicates that a constitutive enzyme may be involved in carcinogenesis by benzo(alpha)pyrene and since this reaction is inhibited by two known anticarcinogens, we suggest that it may be involved in this process.  (+info)

The atherogen 3-methylcholanthrene induces multiple DNA adducts in mouse aortic smooth muscle cells: role of cytochrome P4501B1. (2/54)

OBJECTIVE: 3-Methylcholanthrene (MC), a polycylic aromatic hydrocarbon, induces atherogenesis in mice fed an atherogenic diet. In this study, we tested the hypothesis that MC would induce DNA adducts in mouse aortic smooth muscle cells (SMCs) and that cytochrome P4501B1 (CYP1B1) plays an important role in the activation of MC to genotoxic intermediates. METHODS: Cultured SMCs were treated with MC or the vehicle dimethyl sulfoxide (DMSO), and DNA was isolated after 24 h. In some experiments, the cells were pre-treated with the CYP1B1 inhibitor 1-ethynylpyrene (EP) prior to exposure to MC. DNA adducts were determined by the 32P-postlabeling assay. Aryl hydrocarbon hydroxylase assay was measured by fluorimetry. RESULTS: MC induced formation of 12 DNA adducts that were not observed in DMSO-treated cells. DNA adduct formation was dose-dependent, with maximum response observed at 3 microM. Pre-treatment of cells with EP dramatically suppressed DNA adduct formation by MC. MC treatment caused induction of CYP1B1, but not CYP1A1. CONCLUSION: The induction of high levels of multiple DNA adducts in SMCs by MC suggests that SMCs have a functional enzymatic machinery capable of metabolically activating MC to genotoxic metabolites. The significant inhibition by EP of MC-induced DNA adduct formation indicated that CYP1B1 was the primary CYP enzyme responsible for formation of genotoxic metabolites that may play a role in the induction of atherosclerosis by MC.  (+info)

Development of an assay for aryl hydrocarbon (benzo(a)pyrene) hydroxylase in human peripheral blood monocytes. (3/54)

An assay has been developed and measurements of aryl hydrocarbon [benzo(a)pyrene] hydroxylase have been made in peripheral blood monocytes from a human population. Treatment with benz(a)anthracene in cell culture increased aryl hydrocarbon hydroxylase activity from 6.5 to 37-fold in monocytes from each of 25 apparently healthy donors. A weak correlation (r = 0.38) was observed between the induction ratios obtained with monocytes and lymphocytes from the same donors. Reproducibilities of the monocyte and lymphocyte assays were comparable. In monocytes, the measurement of basal and induced aryl hydrocarbon hydroxylases activity does not require pretreatment with mitogens as is the case with lymphocytes. Monocytes also exhibit a much wider range of induction ratios than do lymphocytes.  (+info)

Mechanism of dioxin action: Ah receptor-mediated increase in promoter accessibility in vivo. (4/54)

We have analyzed dioxin-inducible, Ah receptor-dependent changes in protein-DNA interactions at the CYP1A1 transcriptional promoter in intact mouse hepatoma cells. Our findings indicate that in uninduced cells, the promoter is inaccessible to its cognate binding proteins, which are known to be expressed constitutively. Dioxin induces, in Ah receptor-dependent fashion, an increase in promoter accessibility, which occurs rapidly and does not require ongoing transcription of the CYP1A1 gene. The change in promoter accessibility is not due to an altered pattern of cytosine methylation at the promoter; it probably reflects a 2,3,7,8-tetrachlorodibenzo-p-dioxin- induced change in the chromatin structure. These findings provide new insight into the mechanism of dioxin action and contribute to a better understanding of the regulation of inducible gene transcription in mammalian cells.  (+info)

Regulation of aryl hydrocarbon (benzo-(A)-pyrene) hydroxylase activity in mammalian cells. Induction of hydroxylase activity by N6,O2'-dibutyryl8 adenosine 3':5'-monophosphate and aminophylline. (5/54)

Treatment of hamster BHK cells with N6,O2'-dibutyryl adenosine 3':5'-monophosphate (Bt2cAMP), aminophylline, theophylline, or papaverine increased the level of aryl hydrocarbon (benzo(a)pyrene) hydrolxylase activity. The highese increase, 100-fold, was obtained with Bt2cAMP plus aminophylline or theophylline. N2,O2-Dibutyryl guanosine 3':5'-monophosphate gave a lower induction than Bt2cAMP. The level of hydroxylase activity started to decrease 6 hours after treatment with the inducer and was reduced to almost the uninduced level after 24 hours. Repeated addition of Bt2cAMP and aminophylline did not prevent this decrease. The hydroxylase can also be induced by treating cells with benz(a)anthracene, and the level of this induced activity was maintained for 24 hours. Aminophylline gave a 2- to 8-fold stimulation of the induction by benz(a)anthracene. The enzyme activity induced by Bt2cAMP, aminophylline, and benz(a)anthracene converted benzo(a)pyrene to similar alkali-extractable metabolities with a fluorescence spectra similar to that of 3-hydroxybenzo(a)pyrene. These induced enzyme activities also showed a similar heat stability. Induction by Bt2cAMP and aminophylline, like induction by benz(a)anthracene, required continued protein synthesis and only an initial period of RNA synthesis. Compared to the benz(a)anthracene-induced hydroxylase with a Km of 4.3 muM, the hydroxylase induced by Bt2cAMP and aminophylline showed a Km of 0.14 muM, and was 100-fold more sensitive to inhibition by 7,8-benzoflavone. Increasing the serum concentration in the culture medium stimulated the induction by aminophylline but did not stimulate induction by benz(a)anthracene. The results indicate that aryl hydrocaarbon (benzo(a)pyrene) hydroxylase can be induced by compounds that increase the level of adenosine 3':5'-monophosphate and that this induction and induced enzyme activity differs from that caused by benz(a)anthracene.  (+info)

Activation of 3':5'-cyclic AMP-dependent protein kinase and induction of ornithine decarboxylase as early events in induction of mixed-function oxygenases. (6/54)

The parenteral administration of a single dose of 3-methylcholanthrene to rats caused an increase in the liver of the concentration of 3', 5'-cAMP and of the activity of cAMP-dependent protein kinase (ATP:protein phosphotransferase, EC 2.7.1.37). These events were followed by an increased activity of ornithine decarboxylase (L-ornithine carboxy-lase, EC 4.1.1.17), the enzyme that controls the biosynthesis of polyamines. Finally, the activity of benzo[a]pyrene hydroxylase, as well as the amount of cytochrome P-448, was increased. Similarly, after the administration of phenobarbital, there was first an increase in the cAMP concentration and in the activity of cAMP-dependent protein kinase, then the induction of ornithine decarboxylase, and finally, an enhanced activity of ethylmorphine N-demethylase and an increased content of cytochrome P-450. These data suggest that the drug-induced processes in liver that increase the activities of the oxidative, and presumably other, drug-metabolizing enzymes include the following sequence of events: (1) increase in cAMP concentration and/or activation of cAMP-dependent protein kinase; (2) induction of ornithine decarboxylase; and, (3) induction of drug-metabolizing enzymes.  (+info)

NADH-dependent aryl hydrocarbon hydroxylase in rat liver mitochondrial outer membrane. (7/54)

NADH-dependent 3,4-benzpyrene hydroxylase activity was detected in the purified mitochondrial outer membrane fraction from the livers of rats treated with 3-methylcholanthrene. The specific activity in the outer membrane fraction is nearly equal to that of microsomes, a level too high to be accounted for only by the microsomal contamination. On the other hand, the NADPH-dependent 3,4-benzpyrene hydroxylase activity in the outer membrane fraction is about 50% of that of microsomes. The ratio of the specific activity of NADPH- to NADH-dependent 3,4-benzpyrene hydroxylase in microsomal fraction was about 3.5, while that of the outer membrane fraction was about 1.5. Moreover, it was found that NADH-dependent 3,4-benzpyrene hydroxylase activity in mitochondrial outer membrane from control rat liver was cyanide-insensitive, while that in microsomes was cyanide-sensitive. These results suggest the presence in the mitochondrial outer membrane fraction of aryl hydrocarbon hydroxylase activity which uses as electron donor NADH nearly to the same extent as NADPH. The hydroxylase system is composed of cyanide-insensitive cytochrome P-450 and is inducible markedly by 3-methylcholanthrene treatment. The probable electron transfer pathways in the mitochondrial outer membrane cytochrome P-450 oxidase system are discussed.  (+info)

A relative deficiency of cytochrome P-450 and aryl hydrocarbon [benzo(a)pyrene] hydroxylase in hyperplastic nodules induced by 2-acetylaminofluorene in rat liver. (8/54)

The concentrations of cytochrome P-450 and the activities of aryl hydrocarbon [benzo(a)pyrene] hydroxylase (AHH) and reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase were measured in early (gray-white) and remodeled (brown) hyperplastic nodules induced in the livers of rats with 2-acetylaminofluorene and were compared to the values in control livers and in the liver surrounding the nodules. Cytochrome P-450 content of early (14 weeks) hyperplastic nodules is 30% of the activity of untreated control livers and 48% of the activity of the surrounding liver. AHH activity of the early nodules is 10% of the control activity and 33% of the activity in the surrounding nonnodular liver. Nicotinamide adenine dinucleotide phosphate-cytochrome c reductase activity in the microsomes of early nodules is 76% of the control activity and 78% of the activity in the surrounding liver. In the late remodeled nodules, (22 and 25 weeks), the cytochrome P-450 content is 40% of that of controls and AHH activity is 15% of the control activity. In primary hepatomas induced by 2-acetylaminofluorene, cytochrome P-450 content is 21% of that of controls, AHH activity is 11% of the activity of controls, and reductase is 50% of the control activity. These results, indicating a relative nodule deficiency in some of the cellular components believed to be important in the activation of hepatocarcinogens and hepatotoxins, offer one possible explanation for the relative resistance to carcinogen cytotoxicity of hyperplastic liver nodules.  (+info)

*List of MeSH codes (D12.776)

... aniline hydroxylase MeSH D12.776.422.220.453.040.110 - benzopyrene hydroxylase MeSH D12.776.422.220.453.040.332 - cytochrome p- ... steroid 11-beta-hydroxylase MeSH D12.776.422.220.453.915.730 - steroid 12-alpha-hydroxylase MeSH D12.776.422.220.453.915.737 - ... steroid 16-alpha-hydroxylase MeSH D12.776.422.220.453.915.748 - steroid 17-alpha-hydroxylase MeSH D12.776.422.220.453.915.760 ... cholesterol 7 alpha-hydroxylase MeSH D12.776.422.220.453.915.212 - cholesterol side-chain cleavage enzyme MeSH D12.776.422.220. ...

*List of MeSH codes (D08)

... aniline hydroxylase MeSH D08.244.453.040.110 --- benzopyrene hydroxylase MeSH D08.244.453.040.555 --- cytochrome p-450 cyp1a1 ... aniline hydroxylase MeSH D08.811.682.690.708.170.040.110 --- benzopyrene hydroxylase MeSH D08.811.682.690.708.170.040.332 --- ... steroid 11-beta-hydroxylase MeSH D08.811.682.690.708.170.915.730 --- steroid 12-alpha-hydroxylase MeSH D08.811.682.690.708.170. ... steroid 11-beta-hydroxylase MeSH D08.244.453.915.730 --- steroid 12-alpha-hydroxylase MeSH D08.244.453.915.737 --- steroid 16- ...
Thank you for your interest in spreading the word about Biochemical Society Transactions.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
4.1 Polymorphisms and mutations are both variations in DNA sequence and can arise through the same mechanisms. We use the term polymorphism to refer to DNA variants that are relatively common in populations. Mutations affect the phenotype.. 4.2 Misreading of bases during replication can lead to substitution and can be caused by things like tautomerism, DNA alkylating agents, and irradiation.. 4.3 Looping out of DNA on the template strand during replication; strand breakage, due to radiation and other mutagens; and (discussed in earlier chapters) chromosomal aberrations such as deletions and translocations.. 4.4 Looping out of DNA on the growing strand during replication; transposition; and (discussed in earlier chapters) chromosomal aberrations such as duplications, insertions, and translocation.. 4.5 Benzopyrene is one of many hazardous compounds present in smoke. Benzopyrene is an intercalating agent, which slides between the bases of the DNA molecule, distorting the shape of the double helix, ...
The present study shows the effect of combined dietary deprivation of fat and vitamin A on benzo(a)pyrene (BaP) induced lung carcinogenesis in male Wistar rats. Lung tumors were induced by intratracheal instillation of BaP-Fe2O3 in normal saline. The tumor incidence and tumor burden in control animals were 82% and 2.28 respectively. Fat deficiency decreased the tumor incidence to 57% and tumor burden to 1.66. On the other hand, in vitamin A deficiency these were 83% and 4.02 respectively. Fat deprivation in the diet of animals fed with vitamin A deficient diet decreased the tumor incidence and tumor burden to 69.6% and 2.7 respectively. The results suggest a protective role of low intake of fat in vitamin A deficiency for BaP-induced lung tumorigenesis in rats.
Classification is based on the induction of urinary tract tumors (renal pelvis carcinomas and urinary bladder papillomas) and thyroid tumors (adenomas/carcinomas combined) in one animal species (F344 rats) in one study. Trifluralin is structurally similar to ethalfluralin, a carcinogen in the rat ...
Words Ending In ene: acetylene,achene,advene,agene,akene,alkene,amene,aminobutene,amylene,anadyomene,anthracene,antigene,antivenene,arrasene,azobenzene,bene,benzanthracene,benzene,benzoapyrene,benzopyrene,benzpyrene,buckm
Hydrase definition, any of the class of enzymes that catalyze the addition of a water molecule into a compound without causing hydrolysis. See more.
... : triffic, triffid, triffidian, triffids, triffidy, trifid, trifle, trifled, trifler, trifles, trifling, triflingly, triflingness, triflings, trifluoperazine, trifluralin, trifocal, trifold, trifoliate, trifoliated...
This enzyme belongs to the family of hydrolases, specifically those acting on ether bonds (ether hydrolases). The systematic name of this enzyme class is cis-stilbene-oxide hydrolase. Other names in common use include epoxide hydratase (ambiguous), microsomal epoxide hydratase (ambiguous), epoxide hydrase, microsomal epoxide hydrase, arene-oxide hydratase (ambiguous), benzo[a]pyrene-4,5-oxide hydratase, benzo(a)pyrene-4,5-epoxide hydratase, aryl epoxide hydrase (ambiguous), cis-epoxide hydrolase, and mEH. This enzyme participates in metabolism of xenobiotics by cytochrome p450 ...
2 major biochemical reactions that occur in the peroxisome is the mixed function oxidase and the other is a catalase but what 2 enzymes are involved in these reactions?...beta oxidation one of them ...
Trichloroepoxypropane: A potent epoxide hydrase and aryl hydrocarbon hydroxylase inhibitor. It enhances the tumor-initiating ability of certain carcinogens.
Effects of five organic solvent vehicles on benzo(a)pyrene- hydroxylase (BP-hydroxylase) activity and on the benzo(a)pyrene (50328) (BP) metabolite profile were studied in lung microsomes prepared from male New Zealand white rabbits. The production of 3- OH-benzo(a)pyrene (13345216) and 9-OH-benzo(a)pyrene (17573216) was used to evaluate the effects of dimethyl-sulfoxide (DMSO), acetone, methanol,
lacustrine soils; soil pollution; polluted soils; polycyclic aromatic hydrocarbons; benzopyrene; phenanthrene; bioremediation; biodegradation; soil microorganisms; fertilizer application; nitrogen; phosphorus; nitrogen fertilizers; soil amendments; biosolids; saline soils; alkaline soils; ...
en] Cytochrome P-450-dependent monooxygenases are able to oxidize a large variety of endogenous and exogenous substrates. This paper describes the in vitro interaction between benzopyrene and steroids at the level of two rat liver monooxygenases: steroid-16 alpha-hydroxylase and aryl hydrocarbon hydroxylase (AHH). The results obtained suggest the following conclusions: (1) Steroid-16 alpha-hydroxylase is partially supported by a specific cytochrome P-450 form which is not inhibited in vitro by exogenous substrates. Steroid-16 alpha-hydroxylase is completely independent from cytochrome P1-450 (or P-448), as it is insensitive, in vitro, to alpha-naphthoflavone; (2) AHH is supported by two cytochrome P-450 forms: a specific form which is inducible by methylcholanthrene and inhibited in vitro by alpha-naphthoflavone, but is insensitive to metyrapone and steroids; and another less specific form which is inhibited by metyrapone and steroids in vitro ...
Brundel, dang, I dont like hearing that about 7, 8 benzoflavone . I was about to pick up several bottles of Dermacrine when they were back in stock.
We measured aryl hydrocarbon hydroxylase (AHH) in cultured human lymphocytes. A striking seasonal variation in AHH activity was observed with induced AHH activity levels from January through May measuring approximately 20% of the values during the remainder of the year. AHH inducibility was determined by comparing lymphocytes from the same person cultured with and without the inducer 3-methylcholanthrene. If measurements are limited to the summer and fall seasons when AHH activity is high, AHH inducibility is reproducible for most persons with repeat determinations on the same person averaging 11% from the mean. The values of AHH inducibility in 53 persons ranged from 0.9 to 5.0, but the distribution of values did not fall into three distinct, nonoverlapping classes as reported by others. We were not able to determine the distribution of AHH inducibility in lung cancer patients since lymphocytes from less than half of the patients tested could be successfully cultured.
Lee, S.-M. and Clemens, M. G. (1992), Effect of α-tocopherol on hepatic mixed function oxidases in hepatic ischemia/reperfusion. Hepatology, 15: 276-281. doi: 10.1002/hep.1840150217 ...
The rat and hamster exhibit about a 100-fold difference in sensitivity to the acute toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), with the hamster representing the most resistant species examined to date. The present study compared the induction and inhibition of hepatic TCDD metabolism in these species using suspensions of isolated hepatocytes. Purified 14C-TCDD or 3H-TCDD (2.2 microM) was incubated for 2-6 hr with hepatocytes isolated from untreated, TCDD-pretreated (5 micrograms/kg, ip), 3-methylcholanthrene-pretreated (3-MC, 50 mg/kg, ip, x 3 days), isosafrole-pretreated (ISO, 150 mg/kg, ip, x 3 days), or phenobarbital-pretreated (PB, 80 mg/kg, ip, x 3 days) rats and hamsters. Untreated rat and hamster hepatocytes metabolized TCDD at a similar rate (0.20 and 0.18 pmol/hr/mg, respectively). In both species, TCDD and 3-MC pretreatments elevated the rate of TCDD metabolism by 5-6-fold, while PB pretreatment had no effect. isosafrole modestly increased (1.8-2.5-fold) TCDD metabolism in ...
Alfa Chemistry is the worlds leading provider for special chemicals. We offer qualified products for 21248-00-0(6-BROMOBENZO(a)PYRENE),please inquire us for 21248-00-0(6-BROMOBENZO(a)PYRENE).
GC Application #16187: Polynuclear Aromatic Hydrocarbons (PAHs): US and EU Analytes on ZB-MR1. Column used: Zebron™ ZB-MultiResidue™-1, GC Cap. Column 30 m x 0.25 mm x 0.25 µm, Ea Part#: 7HG-G016-11
GC Application #15560: Polynuclear Aromatic Hydrocarbons (PAHs) on ZB-5MS. Column used: Zebron™ ZB-5MS, GC Cap. Column 20 m x 0.18 mm x 0.18 µm, Ea Part#: 7FD-G010-08
Concomitant exposures to arsenic and polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (BaP) are widespread. While BaP acts by binding to and inducing mutations in critical sites on DNA, the mechanism(s) of arsenic carcinogenesis remains unknown. Data from epidemiological studies of arsenic copper smelter workers and arsenic ingestion in drinking water suggest a positive interaction f
Chan, J T. and Black, H S., "Skin carcinogenesis. Cholesterol-5alpha, 6alpha-epoxide hydrase activity in mouse skin irradiated with ultraviolet light." (1974). Subject Strain Bibliography 1974. 1966 ...
US EPA PC Code ); 001 (PDP Code); 045101 (US EPA PC Code Text ); 1,2,3,4,10,10-Hexachloro-1,4,4a,5,8,8a-hexahydro-(1a,4a,4ab,5a,8a,8ab)-1,4:5,8-dimethanonaphthalene; 1,2,3,4,10,10-Hexachloro-1,4,4a,5,8,8a-hexahydro-endo-1,4-exo-5,8-dimethanonaphthalene; 1,4:5,8-Dimethanonaphthalene, 1,2,3,4,10,10-hexachloro-1,4,4a,5,8,8a-hexahydro-, (1.alpha.,4.alpha.,4a.beta.,5.alpha.,8.alpha.,8; 309-00-2 (CAS number); 309002; 309002 (CAS number without hyphens); 9 (CA DPR Chem Code) ); Aldocit; Aldrex; Aldrin; ALDRIN (CA DPR Chem Code Text ); Aldrin [1,4:5,8-Dimethanonaphthalene, 1,2,3,4,10,10-hexachloro-1,4,4a,5,8,8a-hexahydro-(1.alpha.,4.alpha.,4a.beta.,5.alpha.,8.al; Aldrin/Dieldrin; Aldrine; Compound 118; Drinox; Eldrin; ENT-15949; Hexachlorohexahydro-endo, exo-dimethanonaphthalene; HHDM; HHDN; HHPN; Kortofin; Octalene; OMS 194; OMS-194; SD 2794; Seedrin; Tatuzinho; ...
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Field evaluation of benzopyrene hydroxylase induction as a monitor for marine petroleum pollution | ScienceField evaluation of benzopyrene hydroxylase induction as a monitor for marine petroleum pollution | Science

Field evaluation of benzopyrene hydroxylase induction as a monitor for marine petroleum pollution ... Field evaluation of benzopyrene hydroxylase induction as a monitor for marine petroleum pollution ... Field evaluation of benzopyrene hydroxylase induction as a monitor for marine petroleum pollution ... Field evaluation of benzopyrene hydroxylase induction as a monitor for marine petroleum pollution ...
more infohttp://science.sciencemag.org/content/191/4230/945

Canary Database: Browse by OutcomeCanary Database: Browse by Outcome

Benzopyrene Hydroxylase. 1. Benzopyrenes. 2. Beta Rhythm. 1. Bicarbonates. 3. Bile. 1. Bile Duct Diseases. ...
more infohttp://podcast.canarydatabase.org/browse/outcome/?l=B

Small bowel cancer - 2016 | StartoncologySmall bowel cancer - 2016 | Startoncology

High levels of benzopyrene hydroxylase and folate receptors: benzopyrene, a carcinogen contained in various foods, is converted ... including the benzopyrene hydroxylase, that may protect them against food-derived carcinogens (Delaunoit 2005). ... to less toxic metabolites by the enzyme benzopyrene hydroxylase, which is present in much higher concentrations in the small ...
more infohttp://www.startoncology.net/professional-area/gastro-intestinal-tract-cancers/small-bowel-cancer-2016/?lang=en

List of MeSH codes (D12.776) - WikipediaList of MeSH codes (D12.776) - Wikipedia

... aniline hydroxylase MeSH D12.776.422.220.453.040.110 - benzopyrene hydroxylase MeSH D12.776.422.220.453.040.332 - cytochrome p- ... steroid 11-beta-hydroxylase MeSH D12.776.422.220.453.915.730 - steroid 12-alpha-hydroxylase MeSH D12.776.422.220.453.915.737 - ... steroid 16-alpha-hydroxylase MeSH D12.776.422.220.453.915.748 - steroid 17-alpha-hydroxylase MeSH D12.776.422.220.453.915.760 ... cholesterol 7 alpha-hydroxylase MeSH D12.776.422.220.453.915.212 - cholesterol side-chain cleavage enzyme MeSH D12.776.422.220. ...
more infohttps://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776)

List of MeSH codes (D08) - WikipediaList of MeSH codes (D08) - Wikipedia

... aniline hydroxylase MeSH D08.244.453.040.110 --- benzopyrene hydroxylase MeSH D08.244.453.040.555 --- cytochrome p-450 cyp1a1 ... aniline hydroxylase MeSH D08.811.682.690.708.170.040.110 --- benzopyrene hydroxylase MeSH D08.811.682.690.708.170.040.332 --- ... steroid 11-beta-hydroxylase MeSH D08.811.682.690.708.170.915.730 --- steroid 12-alpha-hydroxylase MeSH D08.811.682.690.708.170. ... steroid 11-beta-hydroxylase MeSH D08.244.453.915.730 --- steroid 12-alpha-hydroxylase MeSH D08.244.453.915.737 --- steroid 16- ...
more infohttps://en.wikipedia.org/wiki/List_of_MeSH_codes_(D08)

Alpha-Naphthoflavone: An Inhibitor of Hydrocarbon Cytotoxicity and Microsomal Hydroxylase | ScienceAlpha-Naphthoflavone: An Inhibitor of Hydrocarbon Cytotoxicity and Microsomal Hydroxylase | Science

Alpha-naphthoflavone inhibits the metabolism of 3,4-benzopyrene and 7,12-dimethylbenz(a)anthracene in hamster enlbryo cell ... Alpha-Naphthoflavone: An Inhibitor of Hydrocarbon Cytotoxicity and Microsomal Hydroxylase Message Subject. (Your Name) has ... Alphla-nalphthoflavone also inhibits the aryl hydrocarbon hydroxylase activity in homogenates of induced hamster embryo cells ...
more infohttp://science.sciencemag.org/content/166/3908/1023

NAVER Academic > Search...NAVER Academic > Search...

Animals, Aryl Hydrocarbon Hydroxylases, metabolism, Benzo(a)pyrene, toxicity, Benzopyrenes, Carcinogens, Cell Transformation, ...
more infohttps://academic.naver.com/search.naver?field=3&query=Cancer+Letters+265%EA%B6%8C+1%ED%98%B8

Competition between benzo[a]pyrene and various steroids for cytochrome P-450-dependent rat liver monooxygenases. - Pasleau...Competition between benzo[a]pyrene and various steroids for cytochrome P-450-dependent rat liver monooxygenases. - Pasleau...

... steroid-16 alpha-hydroxylase and aryl hydrocarbon hydroxylase (AHH). The results obtained suggest the following conclusions: (1 ... This paper describes the in vitro interaction between benzopyrene and steroids at the level of two rat liver monooxygenases: ... Steroid-16 alpha-hydroxylase is completely independent from cytochrome P1-450 (or P-448), as it is insensitive, in vitro, to ... Steroid-16 alpha-hydroxylase is partially supported by a specific cytochrome P-450 form which is not inhibited in vitro by ...
more infohttps://orbi.uliege.be/handle/2268/16448

Warning: 7,8-Benzoflavone Is Carcinogenic - World Class Bodybuilding   ForumWarning: 7,8-Benzoflavone Is Carcinogenic - World Class Bodybuilding Forum

They cant spell and seem to miss the point that 7,8 benzo is very different from benzopyrenes. October 8, 2009 2:09 PM ... Aryl Hydrocarbon Hydroxylase- and Polycyclic Hydrocarbon Tumorigenesis: Effect of the Enzyme Inhibitor 7,8-Benzoflavone on ... Benzopyrene - Wikipedia, the free encyclopedia. Proc. Nat. Acad. Sci. Vol. 69, No. 4, pp. 824-828, April 1972. ... 1. Hydrocarbon Hydroxylase- and Polycyclic Hydrocarbon Tumorigenesis: Effect of the Enzyme Inhibitor 7,8-Benzoflavone on ...
more infohttp://www.worldclassbodybuilding.com/forums/showthread.php?t=101013

Quiz 6 Flashcards by Riley Hunsaker | BrainscapeQuiz 6 Flashcards by Riley Hunsaker | Brainscape

Polycarbon aromatics: e.g., benzopyrene in smoke and cooked meat. • Aflatoxin- fungus on peanuts and other foods- not so much ... Tyrosine hydroxylase inhibitor used for multiple types of cancers such as myelogenous leukemia. ...
more infohttps://www.brainscape.com/flashcards/quiz-6-4363207/packs/6115474

a and l rev - cueFlash - Learn by studying flashcardsa and l rev - cueFlash - Learn by studying flashcards

Dopamine beta hydroxylase Found in effluent ff adrenergic nerve stimulation Dosing rate Clearance x target conc Durham-Humprey ... Benzopyrene, Phenobarbital, phenytoin, rifampin Epinephrine Treat acute hypersensitivity rxn to drugs Esmolol In OR develop arr ...
more infohttps://cueflash.com/decks/tag/irregular/tag/respiration/100080/a_and_l_rev

dict.md | Hdict.md | H

Hydroxylase, Aniline. Hydroxylase, Benzopyrene. Hydroxylase, Butyrobetaine. hydroxylase, cinnamate 4-. Hydroxylase, Collagen ...
more infohttp://en.dict.md/H/238

The EPA National Library Catalog | EPA National Library Network | US EPAThe EPA National Library Catalog | EPA National Library Network | US EPA

Conversely, toxaphene decreased the incidence of BP-induced tumors and inhibited BP hydroxylase activity in the lungs of the A/ ... Benzopyrene ; Oncogenesis ; Phosphorothiotic acid/O-O-(dimethyl-ester)-O-(nitrophenyl-ester) ... These results suggest that increased BP hydroxylase activity in tissues tends to enhance tumor formation and a decrease in the ... On the other hand, toxaphene enhanced benzo(a)pyrene (BP)-induced tumors and increased BP hydroxylase activity in the ...
more infohttps://cfpub.epa.gov/ols/catalog/advanced_brief_record.cfm?FIELD1=SUBJECT&INPUT1=Parathion.&TYPE1=EXACT&LOGIC1=AND&COLL=&SORT_TYPE=MTIC&item_count=48&item_accn=360578

Velvita: Deer Velvet Antler Dietary SupplementVelvita: Deer Velvet Antler Dietary Supplement

I. Effect of antler and old antler on liver injury induced by benzopyrene in rats. Proc. Japanese Soc. Food & Nutrition 23: 9. ... Nerve fibres immunoreactive to neuropeptide Y, C-flanking peptide of neuropeptide Y and tyrosine hydroxylase, all present in ...
more infohttp://velvita.com/research.htm

Gene mutation and molecular medicine Chapter 15 - PDFGene mutation and molecular medicine Chapter 15 - PDF

... like benzopyrene) Radiation X-rays create free radicals UV creates thymine dimers Artificial or Natural mutations HOT SPOTS FOR ... abnormal enzyme phenylalanine hydroxylase normally catalyzes conversion of dietary phenylalanine to tyrosine. Has tryptophan ...
more infohttp://docplayer.net/21881077-Gene-mutation-and-molecular-medicine-chapter-15.html

Molecular Mechanisms of Multistage CarcinogenesisMolecular Mechanisms of Multistage Carcinogenesis

phenylalanine hydroxylase products*ADH1A products*CYP1B1 products*ADH6 products*ADH4 products*ADH1C products*ADH1B products* ... benzopyrenes*aromatic polycyclic hydrocarbons*quinones*carcinogens*dna adducts*molecular structure*reactive oxygen species* ... aryl hydrocarbon hydroxylases*tumor cell line*isomerism*dna*catalysis*aldehyde reductase*indicators and reagents*g1 phase*s ...
more infohttp://www.labome.org/grant/p01/ca/molecular/mechanisms/molecular-mechanisms-of-multistage-carcinogenesis-7101871.html

Bronchogenic Carcinoma Etiopathogenesis | EpomedicineBronchogenic Carcinoma Etiopathogenesis | Epomedicine

Polycyclic Aromatic Hydrocarbons (PAH): e.g. benzopyrene produces p53 mutation (G to T transversion) ... Identified gene: CYP1A1 (of Cytochrome P-450 family) - codes for aryl hydrocarbon hydroxylase ...
more infohttps://epomedicine.com/medical-students/bronchogenic-carcinoma-lung-cancer/

Benzphetamine | definition of benzphetamine by Medical dictionaryBenzphetamine | definition of benzphetamine by Medical dictionary

... aniline hydroxylase (AH), acetanilide hydroxylase (AAH), benzphetamine demethylase (BD), aminopyrine demethylase (APD), N.. ...
more infohttps://medical-dictionary.thefreedictionary.com/benzphetamine

Benzoate | Article about benzoate by The Free DictionaryBenzoate | Article about benzoate by The Free Dictionary

Benzo A Pyrene Hydroxylase. *Benzo A-Pyrene-Diol-Epoxide. *Benzo pyrene. *Benzo pyrene ...
more infohttps://encyclopedia2.thefreedictionary.com/benzoate

Chemical Carcinogenesis: Interactions of Carcinogens with Nucleic Acids | Springer for Research & DevelopmentChemical Carcinogenesis: Interactions of Carcinogens with Nucleic Acids | Springer for Research & Development

Prodi, G., Rocchi, P., And Grilli, S., 1970b, Binding of 7,12-dimethylbenz(a)anthracene and benzopyrene to nucleic acids and ... Ribonucleic acid synthesis-dependent induction of aryl hydrocarbon hydroxylase in the absence of ribosomal ribonucleic acid ... Tso P. O. P., Lesko, S. A., And Umans, R. S., 1969, The physical binding and the chemical linkage of benzopyrene to ...
more infohttps://rd.springer.com/chapter/10.1007%2F978-1-4615-6598-7_10

WGC2010WGC2010

IHC reveals breakable varicose, tyrosine hydroxylase (TH)+ nerves (arrowheads) coursing in the medulla (med) of a lymph node. ... an capacity that is shared with Benzanthracene Benzopyrene Dibenzh]anthracene Fig. As BRCA1 and BRCA2 sequencing exchange for ...
more infohttp://www.wgc2010.sk/index.php/en/messageboard/349
  • Alpha-naphthoflavone inhibits the metabolism of 3,4-benzopyrene and 7,12-dimethylbenz(a)anthracene in hamster enlbryo cell cultures and protects the cells against the inhibition of cell multiplication by these carcinogens. (sciencemag.org)
  • On the other hand, toxaphene enhanced benzo(a)pyrene (BP)-induced tumors and increased BP hydroxylase activity in the forestomach of the Ha/ICR mice and carbaryl enhanced BP-induced tumors and increased BP hydroxylase activity in the lungs of the A/J mice. (epa.gov)
  • Conversely, toxaphene decreased the incidence of BP-induced tumors and inhibited BP hydroxylase activity in the lungs of the A/J mice. (epa.gov)