Compounds with a core of fused benzo-pyran rings.
A plant genus of the family BERBERIDACEAE which is used in DRUGS, CHINESE HERBAL. Members contain flavonol glycosides including epimedins, icariin and noricariin.
Chemical agents or odors that stimulate sexual desires. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
A system of traditional medicine which is based on the beliefs and practices of the Chinese culture.
Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China.
A group of 3-hydroxy-4-keto-FLAVONOIDS.
The state of the PENIS when the erectile tissue becomes filled or swollen (tumid) with BLOOD and causes the penis to become rigid and elevated. It is a complex process involving CENTRAL NERVOUS SYSTEM; PERIPHERAL NERVOUS SYSTEMS; HORMONES; SMOOTH MUSCLES; and vascular functions.

Isolation of SMTP-3, 4, 5 and -6, novel analogs of staplabin, and their effects on plasminogen activation and fibrinolysis. (1/1330)

Four novel triprenyl phenol metabolites, designated SMTP-3, -4, -5, and -6, have been isolated from cultures of Stachybotrys microspora IFO 30018 by solvent extraction and successive chromatographic fractionation using silica gel and silica ODS columns. A combination of spectroscopic analyses showed that SMTP-3, -4, -5, and -6 are staplabin analogs, containing a serine, a phenylalanine, a leucine or a tryptophan moiety in respective molecules in place of the N-carboxybutyl portion of the staplabin molecule. SMTP-4, -5, and -6 were active at 0.15 to 0.3 mM in enhancing urokinase-catalyzed plasminogen activation and plasminogen binding to fibrin, as well as plasminogen- and urokinase-mediated fibrinolysis. On the other hand, the concentration of staplabin required to exert such effects was 0.4 to 0.6 mM, and SMTP-3 was inactive at concentrations up to 0.45 mM.  (+info)

Inhibition of endothelium-dependent hyperpolarization by endothelial prostanoids in guinea-pig coronary artery. (2/1330)

1. In smooth muscle of the circumflex coronary artery of guinea-pig, acetylcholine (ACh, 10(-6) M) produced an endothelium-dependent hyperpolarization consisting of two components. An initial component that occurs in the presence of ACh and a slow component that developed after ACh had been withdrawn. Each component of the hyperpolarization was accompanied by an increase in membrane conductance. 2. Indomethacin (5 x 10(-6) M) or diclofenac (10(-6) M), both inhibitors of cyclooxygenase, abolished only the slow hyperpolarization. The initial hyperpolarization was not inhibited by diclofenac nor by nitroarginine, an inhibitor of nitric oxide synthase. 3. Both components of the ACh-induced hyperpolarization were abolished in the presence of atropine (10(-6) M) or high-K solution ([K+]0 = 29.4 mM). 4. The interval between ACh-stimulation required to generate an initial hyperpolarization of reproducible amplitude was 20 min or greater, but it was reduced to less than 5 min after inhibiting cyclooxygenase activity. Conditioning stimulation of the artery with substance P (10(-7) M) also caused a long duration (about 20 min) inhibition of the ACh-response. 5. The amplitude of the hyperpolarization generated by Y-26763, a K+-channel opener, was reproducible within 10 min after withdrawal of ACh. 6. Exogenously applied prostacyclin (PGI2) hyperpolarized the membrane and reduced membrane resistance in concentrations over 2.8 x 10(-9)M. 7. At concentrations below threshold for hyperpolarization and when no alteration of membrane resistance occurred, PGI2 inhibited the initial component of the ACh-induced hyperpolarization. 8. It is concluded that endothelial prostanoids, possibly PGI2, have an inhibitory action on the release of endothelium-derived hyperpolarizing factor.  (+info)

A novel role for carbonic anhydrase: cytoplasmic pH gradient dissipation in mouse small intestinal enterocytes. (3/1330)

1. The spatial and temporal distribution of intracellular H+ ions in response to activation of a proton-coupled dipeptide transporter localized at the apical pole of mouse small intestinal isolated enterocytes was investigated using intracellular carboxy-SNARF-1 fluorescence in combination with whole-cell microspectrofluorimetry or confocal microscopy. 2. In Hepes-buffered Tyrode solution, application of the dipeptide Phe-Ala (10 mM) to a single enterocyte reduced pHi locally in the apical submembranous space. After a short delay (8 s), a fall of pHi occurred more slowly at the basal pole. 3. In the presence of CO2/HCO3--buffered Tyrode solution, the apical and basal rates of acidification were not significantly different and the time delay was reduced to 1 s or less. 4. Following application of the carbonic anhydrase inhibitor acetazolamide (100 microM) in the presence of CO2/HCO3- buffer, addition of Phe-Ala once again produced a localized apical acidification that took 5 s to reach the basal pole. Basal acidification was slower than at the apical pole. 5. We conclude that acid influx due to proton-coupled dipeptide transport can lead to intracellular pH gradients and that intracellular carbonic anhydrase activity, by facilitating cytoplasmic H+ mobility, limits their magnitude and duration.  (+info)

Regulation of mitochondrial KATP channel by redox agents. (4/1330)

The ATP-dependent K+ channel (KATP) was purified from the inner mitochondrial membrane and reconstituted into lipid bilayer membranes. KATP activity was inhibited by high concentrations of ATP and ADP, but activated by low concentrations (up to 200 microM) of ADP. p-Diethylaminoethylbenzoate (DEB) acted as a KATP opener: at micromolar concentrations, it reversed inhibition by ATP and ADP and it also prevented KATP rundown. Pelargonidine, extracted from flowers of Pelargonium, reduced spontaneous activity of KATP channels and diminished their potentiation by DEB. Their opposite action on KATP corresponded with their opposite redox properties in reactions with free radicals: DEB behaved as an electron donor, whereas pelargonidine acted as an electron acceptor. We hypothesize that thiol groups on mitoKATP are targets for redox-active ligans.  (+info)

The action of the benzopyrones on an experimental model of lymphoedema: a contribution to their mode of action. (5/1330)

A number of preparations containing benzopyrones are used clinically as a therapy for lymphoedema; however, their exact mode of action is not well known. This work presents evidence which indicates that, as in the treatment of thermally induced oedemas, the benzopyrones work by enhancing the lysis of the accumulated proteins. This is evidenced by reduced levels of total protein in the extracellular compartment of the skin, while peptides and amino acids were increased in the serum at 6 and 12 h respectively after the drug's administration. Failure to observe very marked increases in peptides and amino acids at other times in the serum and skin was attributed to the rapid incorporation of these into the large number of maturing phagocytes which enter the lymphoedematous tissues. Likewise, protease activity levels were not elevated as expected. This possibly was the consequence of a number of factors including serum deactivation, inhibition of release and membrane stabilization.  (+info)

The role of humic substances in drinking water in Kashin-Beck disease in China. (6/1330)

We conducted in vitro and in vivo assays in a selenium-deficient system to determine if organic matter (mainly fulvic acid; FA) is involved in a free radical mechanism of action for Kashin-Beck disease. Cartilage cell culture experiments indicated that the oxy or hydroxy functional groups in FA may interfere with the cell membrane and result in enhancement of lipid peroxidation. Experiments with rats demonstrated that toxicity from FA was reduced when the hydroxy group was blocked. Induction of lipid peroxidation by FA in liver and blood of rats was similar to that exhibited by acetyl phenyl hydrazine. FA accumulated in bone and cartilage, where selenium rarely concentrates. In addition, selenium supplementation in rats' drinking water inhibited the generation of oxy-free radicals in bone. We hypothesized that FA in drinking water is an etiological factor of Kashin-Beck disease and that the mechanism of action involves the oxy and hydroxy groups in FA for the generation of free radicals. Selenium was confirmed to be a preventive factor for Kashin-Beck disease.  (+info)

Disposition and metabolism of 2-(2''(1'',3''-dioxolan-2-yl)-2- methyl-4-(2'-oxopyrrolidin-1-Yl)-6-nitro-2h-1-benzopyran (SKP-450) in rats. (7/1330)

The disposition and metabolism of the new antihypertensive agent 2-(2"(1", 3"-dioxolan-2-yl)-2-methyl-4-(2'-oxopyrrolidin-1-yl)-6-nitro -2H-1-benzopyran (SKP-450) were investigated in male rats after single oral and i.v. doses of 14C-labeled compound. After an oral 2.0 mg/kg dose, mean radiocarbon recovery was 98.2 +/- 2.3% with 31.1 +/- 7.3% in the feces and 67.1 +/- 14.3% in the urine. Biliary excretion of radioactivity for the first 24-h period was approximately 40%, suggesting that SKP-450 is cleared either by hepatobiliary excretion or by renal excretion. SKP-450 was well absorbed; bioavailability calculated on the basis of radioactivity was 68 to 97%. Tissue distribution of the radioactivity was widespread with high concentrations in the liver and kidney but low central nervous system penetration. Radio-HPLC analysis of bile and urine from rats indicated the extensive metabolism of SKP-450 into oxidative metabolites. Oxidative metabolism of the dioxolanyl ring resulted in an aldehyde intermediate, subsequently confirmed in vitro, which was further oxidized to the corresponding carboxylic acid (M1) or reduced to the corresponding alcohol (M3). No parent drug was detected in the urine or bile. Glucuronide conjugate of M3 was also detected in urine and bile, accounting for 5.8 +/- 2.1 and 8.9 +/- 3. 7% of the excreted radioactivity, respectively. Quantitative data obtained from plasma samples suggest that the majority of circulating radioactivity was associated with metabolites. Our results suggest that the long duration of pharmacological activity of SKP-450 (>10 h) is largely attributable to its metabolites.  (+info)

Pharmacokinetic profile of alniditan nasal spray during and outside migraine attacks. (8/1330)

AIMS: To compare the pharmacokinetic profile of intranasal alniditan during and outside migraine attacks, and to investigate the relationship between initial rise of alniditan plasma concentration, and headache improvement. METHODS: Twenty-seven migraine patients (age: 18-65 years) were randomized to receive alniditan 2 mg or 4 mg, and investigated both during and outside a migraine attack. Maximal plasma concentrations (Cmax), time to Cmax (tmax), and the area under the curve over 2 h (AUC(0,2 h)), were calculated from the individual plasma concentration-time profile, obtained from 10 blood samples in each patient, during each of the two administrations. RESULTS: Alniditan was rapidly absorbed into the systemic circulation (tmax=11 min). All investigated pharmacokinetic parameters (Cmax, tmax, AUC(0,2 h)) were similar during and outside migraine attacks, both in the 2 mg (n = 13) and the 4 mg group (n = 14). In the 4 mg group, during attacks, mean plasma alniditan concentration at 5 min after administration (Ct=5) in responders (21+/-16 ng ml(-1); n=10) was significantly higher than the Ct=5 in nonresponders (3+/-3 ng ml(-1); P=0.01; n=4). However, the Cmax and AUC(0,2 h) in responders (33+/-18 ng ml(-1) and 12+/-6 ng ml(-1) h) were also significantly higher than the Cmax and AUC(0,2 h) in nonresponders (13+/-9 ng ml(-1); P=0.048 and 5+/-3 ng ml(-1) h; P=0.03). CONCLUSIONS: Absorption of alniditan nasal spray was not affected by migraine attacks, although 95% confidence intervals were wide. Early rise of plasma concentrations and the amount of drug in the circulation were related to headache improvement in the higher dose group.  (+info)

Benzopyrans are a class of chemical compounds that contain a benzene ring fused to a pyran ring. They are also known as chromenes. Benzopyrans can be found in various natural sources, including plants and fungi, and have been studied for their potential biological activities. Some benzopyrans have been found to have anti-inflammatory, antioxidant, and anticancer properties. However, some benzopyrans can also be toxic or have other adverse health effects, so it is important to study their properties and potential uses carefully.

Epimedium is a genus of plants in the family Berberidaceae, also known as barberry family. It is commonly known as Horny Goat Weed due to its traditional use as an aphrodisiac in Chinese medicine. The active compound of Epimedium, icariin, has been studied for its potential effects on improving sexual function and treating erectile dysfunction. However, more research is needed to confirm these findings and establish the safety and efficacy of this herb as a treatment for sexual dysfunction.

It's important to note that natural does not always mean safe, and it's crucial to consult with a healthcare provider before starting any new supplement regimen, including Epimedium, to ensure safety and avoid potential interactions with other medications.

Aphrodisiacs are substances that are believed to stimulate sexual desire or increase sexual pleasure. They can come in various forms, including foods, drinks, and medications. Some claimed aphrodisiacs include oysters, chocolate, certain herbs like ginseng and gingko biloba, as well as drugs such as Viagra. However, it's important to note that the effectiveness of most aphrodisiacs is not supported by scientific evidence, and some may even have harmful side effects if misused or taken in large quantities.

It's always recommended to consult with a healthcare professional before taking any substances for sexual purposes.

An encyclopedia is a comprehensive reference work containing articles on various topics, usually arranged in alphabetical order. In the context of medicine, a medical encyclopedia is a collection of articles that provide information about a wide range of medical topics, including diseases and conditions, treatments, tests, procedures, and anatomy and physiology. Medical encyclopedias may be published in print or electronic formats and are often used as a starting point for researching medical topics. They can provide reliable and accurate information on medical subjects, making them useful resources for healthcare professionals, students, and patients alike. Some well-known examples of medical encyclopedias include the Merck Manual and the Stedman's Medical Dictionary.

Traditional Chinese Medicine (TCM) is a system of medicine that has been developed in China over thousands of years. It is based on the philosophy that the body's vital energy (Qi) circulates through a network of channels called meridians, and that disease results from an imbalance or blockage in this flow of Qi.

TCM uses a variety of treatments to restore balance and promote health, including acupuncture, herbal medicine, moxibustion (the burning of herbs near the skin), cupping, dietary therapy, and tuina (Chinese massage). The use of Chinese herbal medicines is a major component of TCM, with formulas often consisting of combinations of several different herbs tailored to the individual patient's needs.

In addition to these treatments, TCM practitioners may also use diagnostic techniques such as pulse diagnosis and tongue examination to assess a person's overall health and determine the underlying cause of their symptoms. The goal of TCM is not only to treat specific symptoms or diseases but to address the root causes of illness and promote overall wellness.

Chinese herbal drugs, also known as traditional Chinese medicine (TCM), refer to a system of medicine that has been practiced in China for thousands of years. It is based on the belief that the body's vital energy, called Qi, must be balanced and flowing freely for good health. TCM uses various techniques such as herbal therapy, acupuncture, dietary therapy, and exercise to restore balance and promote healing.

Chinese herbal drugs are usually prescribed in the form of teas, powders, pills, or tinctures and may contain one or a combination of herbs. The herbs used in Chinese medicine are typically derived from plants, minerals, or animal products. Some commonly used Chinese herbs include ginseng, astragalus, licorice root, and cinnamon bark.

It is important to note that the use of Chinese herbal drugs should be under the guidance of a qualified practitioner, as some herbs can interact with prescription medications or have side effects. Additionally, the quality and safety of Chinese herbal products can vary widely depending on the source and manufacturing process.

Flavonols are a type of flavonoid, which is a class of plant and fungal metabolites. They are characterized by the presence of a 3-hydroxyflavone skeleton. Flavonols are found in a variety of plants and are known for their antioxidant properties. Some common dietary sources of flavonols include onions, kale, broccoli, apples, tea, and red wine. They have been studied for their potential health benefits, including reducing the risk of chronic diseases such as cancer and cardiovascular disease. Flavonols are also known to have anti-inflammatory, neuroprotective, and antimicrobial properties.

Penile erection is a physiological response that involves the engagement of the corpus cavernosum and spongiosum (erectile tissue) of the penis with blood, leading to its stiffness and rigidity. This process is primarily regulated by the autonomic nervous system and is influenced by factors such as sexual arousal, emotional state, and certain medications or medical conditions. A penile erection may also occur in non-sexual situations, such as during sleep (nocturnal penile tumescence) or due to other physical stimuli.

Some benzopyrans have shown anticancerous activity in vitro. The radical form of benzopyran is paramagnetic. The unpaired ... resulting in 1-benzopyran (chromene) and 2-benzopyran (isochromene)-the number denotes where the oxygen atom is located by ... Benzopyran is a polycyclic organic compound that results from the fusion of a benzene ring to a heterocyclic pyran ring. ... Commonly, benzopyran is encountered in the reduced state, in which it is partially saturated with one hydrogen atom, ...
1-benzopyran-4-one) Coumarin (1-benzopyran-2-one) Certain simple benzopyrones have clinical medical value as an edema modifiers ... Benzopyrone may refer to either of two ketone derivatives of benzopyran which constitute the core skeleton of many flavonoid ... Review of benzypyrone drugs and edema (Benzopyrans). ...
... (1H-2-benzopyran-1-one; 3,4-benzo-2-pyrone) is a lactone, a type of natural organic compound. Thunberginol A and B ... 6-dimethoxy-1H-2-benzopyran-1-one can be found in Huáng bǎi (Phellodendron chinense), one of the fifty fundamental herbs of ...
November 1986). "Synthesis and antihypertensive activity of 4-(cyclic amido)-2H-1-benzopyrans". Journal of Medicinal Chemistry ... EP 76075, Evans, John Morris; Buckingham, Robert Edwin & Willcocks, Kenneth, "Pharmaceutically active benzopyran compounds", ... "Benzopyran isomers", published 1984-10-03, assigned to Beecham Group plc U.S. Patent 3,444,236 "Synthesis of 4-Chlorobutyryl ...
June 2008). ""Hybrid" Benzofuran-Benzopyran Congeners as Rigid Analogues of Hallucinogenic Phenethylamines". Bioorganic & ...
Schultz DM, Prescher JA, Kidd S, Marona-Lewicka D, Nichols DE, Monte A (June 2008). "'Hybrid' benzofuran-benzopyran congeners ...
Schultz DM, Prescher JA, Kidd S, Marona-Lewicka D, Nichols DE, Monte A (June 2008). "'Hybrid' benzofuran-benzopyran congeners ...
... benzopyrans and benzofurans. Extracts of the plant have shown antifungal, anticyanobacterial, and antitermite effects. A number ...
"Benzopyrans are selective estrogen receptor beta agonists with novel activity in models of benign prostatic hyperplasia". J. ... Benzopyrans, Cyclopentanes, Diols, Selective ERβ agonists, Synthetic estrogens, All stub articles, Genito-urinary system drug ...
"Benzopyrans are selective estrogen receptor beta agonists with novel activity in models of benign prostatic hyperplasia". J. ... Benzopyrans, Diols, Selective ERβ agonists, Synthetic estrogens, Cyclopentanes, All stub articles, Genito-urinary system drug ...
... benzopyran-6-ones". Heterocycles. 23 (4): 903. doi:10.3987/R-1985-04-0903. V. A. Tuskaev (April 2013). "Synthesis and ...
4] Anka Bojilova, Nestor Rodios, Rositsa Nicolova, Christo Ivanov; Reactions of 3-acyl-substituted 2H-1-benzopyran-2-ones with ... 3] Archived 2011-07-10 at the Wayback Machine Christo Ivanov, Anka Bojilowa; Umwandlung von 2-Oxo-2H-1-benzopyran-3- ... Cyclopropanation Reaction of 3-Acyl-2H-1-Benzopyran-2-ones with Phenacylbromide in Phase Transfer Systems, 1993, Tetrahedron, ...
... benzopyran with potent NF-κB inhibitory activity from Aglaia ponapensis". Bioorganic & Medicinal Chemistry Letters. 17 (1): 109 ...
2002;507:365-9. The novel benzopyran class of selective cyclooxygenase-2 inhibitors-part I: the first clinical candidate. Wang ... "The novel benzopyran class of selective cyclooxygenase-2 inhibitors-part I: The first clinical candidate". Bioorganic & ...
It reacts with malononitrile to form 2-imino-6-methoxy-2H-1-benzopyran-3-carbonitrile. It can be reduced by sodium borohydride ...
... is a benzopyran tannin and an antioxidant that has many potential uses in medicine. It has been found to be ...
The flavans are benzopyran derivatives that use the 2-phenyl-3,4-dihydro-2H-chromene skeleton. They may be found in plants. ...
... benzopyran-2-one pigments from Tricholoma aurantium (Agaricales)". European Journal of Organic Chemistry. 2000 (4): 603-608. ...
Patent US 4034113 Hellberg MR, Namil A. Benzopyran analogs and their use for the treatment of glaucoma. Patent US 7396856 ...
It is thus of interest that a compound based on a benzopyran manifests much the same activity. Alkylation of phenol with 2- ... Benzopyrans, 5-HT1D agonists, All stub articles, Analgesic stubs). ...
... (or 1,4-benzopyrone) is a derivative of benzopyran with a substituted keto group on the pyran ring. It is an isomer of ...
4-Dihydro-2-methylene-2H-1-benzopyran". Organic Syntheses.; Collective Volume, vol. 8, p. 512 David P. Sebesta " ...
"Synthesis and anti-inflammatory activity of N-substituted 2-oxo-2H-1-benzopyran-3-carboxamides and their 2-iminoanalogues". ...
4-dihydro-2-methylene-2H-1-benzopyran". Org. Synth. 69: 72. doi:10.15227/orgsyn.069.0072. Negishi, E.; Matsushita, H. (1984). " ...
4-dihydro-2-methylene-2H-1-benzopyran". Org. Synth. 69: 72. doi:10.15227/orgsyn.069.0072. L. F. Cannizzo & R. H. Grubbs (1985 ...
1994). "A Specific Inhibitor of Phosphatidylinositol 3-Kinase, 2-(4-Morpholinyl)-8-phenyl-4H-l-benzopyran-4-one (LY294002)". ...
6-dihydroxy-3-phenyl-1H-2-benzopyran: a potent and selective D1 agonist". Journal of Medicinal Chemistry. 33 (11): 2948-50. doi ...
Stereospecific synthesis of 2,3-dihydro-c-3-substituted-t-3-methyl-r-2-phenyl-4H-1-benzopyran-4-ones". Journal of Heterocyclic ...
New Endiandric Acid and Benzopyran Derivatives Isolated from B. Oligandra. Aust. J. of Chem. 1994, 47, 587-607.s Chouna, J. R ...
These are polycyclic aromatic compounds containing a 1-benzopyran moiety with a ketone group at the C2 carbon atom (1- ... benzopyran-2-one). Pomegranate fruits, walnuts or raspberries are sources of ellagitannins. Ellagitannins are hydrolyzed in the ...
Some benzopyrans have shown anticancerous activity in vitro. The radical form of benzopyran is paramagnetic. The unpaired ... resulting in 1-benzopyran (chromene) and 2-benzopyran (isochromene)-the number denotes where the oxygen atom is located by ... Benzopyran is a polycyclic organic compound that results from the fusion of a benzene ring to a heterocyclic pyran ring. ... Commonly, benzopyran is encountered in the reduced state, in which it is partially saturated with one hydrogen atom, ...
Sergio Valente, Zhanjie Xu, Emilie Bana, Clemens Zwergel, Antonello Mai, et al.. Reactivity of 4-Vinyl-2H-1-benzopyran-2-ones ... Reactivity of 4-Vinyl-2H-1-benzopyran-2-ones in Diels-Alder Cycloaddition Reactions: Access to Coumarin-Based Polycycles with ...
Categories: Benzopyrans Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, CopyrightRestricted 6 ...
4-Hydroxy-3-(3-oxo-1-phenyl butyl)-2H-1-benzopyran-2-one. 81-81-2. GN4550000. ...
4-(3,4-dihydro-2,2,4-trimethyl-2h-1-benzopyran-4-yl)fenol. 122970-87-0. 56954-97-3. 122970-83-6. InChI=1S/C18H20O2/c1-17(2)12- ... 4-(3,4-dihydro-2,2,4-trimethyl-2H-1-benzopyran-4-yl)fenol. 4-(2,2,4-trimethylchroman-4-yl)phenol. 1,2,3,4,5,6- ...
4,9-Dimethoxy-7-(2-phenylethenyl)-5H-furo[3,2-g][1]benzopyran-5-one ...
Benzopyran derivatives have strong relaxing activity on blood vessels, cardiac muscles, and smooth muscles. The present study ... 2-amino-4H-benzopyran derivatives have received considerable attention due to their valuable biological and medicinal ... Aqueous media preparation of 2-amino-4H-benzopyran derivatives using cerium oxide nanoparticles as a recyclable catalyst Bita ... properties such as anticoagulant, antispasmodic, diuretic, and ... Read More 2-amino-4H-benzopyran derivatives have received ...
A specific inhibitor of phos- phatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4- one (LY294002). J Biol ...
7-trihydroxy-4H-1-benzopyran-4-one. ...
Compound 1 was a new benzopyran glycoside. Compounds 4, 6-10, 12, and 13 were isolated for the first time from Gentiana plants ...
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one Medicine & Life Sciences 39% ...
2H-1-benzopyran-6carbonitrile) induces relaxation of vascular smooth muscle by a mechanism consistent with opening of K ... 2H-1-benzopyran-6-carbonitrile). Comparisons have been made with cromakalim and/or its active (-) enantiomer, BRL 38227. Rat ...
pyran-2-ones: index PYRONES + LACTONES but BENZOPYRAN-2-ONES is available; for cyclic lactones over 12 atoms consider ...
1]Benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one, 1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-, (2R,6aS,12aS ... 1]Benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one, 1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-, (2R,6aS,12aS ...
D3.383.663.283.266.450.175 Benzopyrans D3.830.219 D3.383.663.283 Berkelium D1.268.33.100 beta-Defensins D12.644.276.87.54 ...
D3.383.663.283.266.450.175 Benzopyrans D3.830.219 D3.383.663.283 Berkelium D1.268.33.100 beta-Defensins D12.644.276.87.54 ...
D3.383.663.283.266.450.175 Benzopyrans D3.830.219 D3.383.663.283 Berkelium D1.268.33.100 beta-Defensins D12.644.276.87.54 ...
Benzopyrans D3.438.150 D3.633.100.150 Benzopyrene Hydroxylase D8.244.453.40.110 D8.244.453.05.110 D8.811.682.690.708.170.40.110 ...
Benzopyrans D3.438.150 D3.633.100.150 Benzopyrene Hydroxylase D8.244.453.40.110 D8.244.453.05.110 D8.811.682.690.708.170.40.110 ...
Tonabersat is a novel benzopyran compound that markedly reduces cortical spreading depression (CSD) and CSD-associated events ...
Dihydropyridine-, pyridine-, Benzopyran-4-one- & Triazoloquinazoline Derivative, Their Preparation, & Their Use as Adenosine ... Dihydropyridine-, pyridine-, Benzopyran-4-one- & Triazoloquinazoline Derivative, Their Preparation, & Their Use as Adenosine ...
2H-1-Benzopyran-2-o. ne, 7-[[(5ξ)-2-(ace. tylamino)-2-deoxy-β. -D-ribo-hexopyranos. yl]oxy]-4-methyl- [ACD/Index Name] ... 2H-1-Benzopyran-2-o. ne,7-[[2-(acetylami. no)-2-deoxy-b-D-glu. copyranosyl]oxy]-4-. methyl- ...
ADL5859, N,N-diethyl-4-(5-hydroxyspiro[2H-1-benzopyran-2,4′-piperidin]-4-yl)-benzamide; CHO-K1-hDOPr, Chinese hamster ovary ...
2H-1-Benzopyran-2-one (coumarin). • 2,6-Octadien-1-ol, 3,7-dimethyl-, (2E)- (geraniol). • 3 and 4-(4-Hydroxy-4-methylpentyl) ...
Abbreviations: BP, benzopyran; SERM, selective estrogen receptor modulator.. Tables. Table 2. Animal and human studies showing ...
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-, (2R)- (59-02-9). Citation ... Home » Chemical Effects in Biological Systems (CEBS) » 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12- ... 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-, (2R)- (59-02-9). Chemical Effects ...
MeSH Terms: Animals; Benzopyrans/pharmacology; Benzopyrans/therapeutic use*; Chemical Warfare Agents/toxicity*; Collagen Type ...
Benzopyrans / pharmacology Actions. * Search in PubMed * Search in MeSH * Add to Search ...
Benzopyrans / metabolism Actions. * Search in PubMed * Search in MeSH * Add to Search ...
In 44% of the animals tested the combined treatment caused complete regression of ovarian cancer. Combined observations indicate TPL may be an effective adjunct chemotherapy for ovarian cancer.
Chemical Name: Disodium 5-5-[(2-hydroxytrimethylene)dioxy]bis[4-oxo-4H-1-benzopyran-2-carboxylate] ...
Chemical Name: disodium 5-5 - [(2-hydroxytrimethylene)dioxy] bis [4-oxo-4H-1-benzopyran-2-carboxylate]. ...
KR-31831, benzopyran derivative, inhibits VEGF-induced angiogenesis of HUVECs through suppressing KDR expression.. Park SY; Seo ...
Galaxolide (HHCB) 1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethyl-cyclopenta-γ-[2]-benzopyran. 1222-05-5. C18H26O. 258.4. 5.9a. ... Musk ketone (MK), MX, HHCB (1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethyl-cyclopenta-γ-[2]-benzopyran), and Celestolide (ADBI; 4 ...
Benzopyrans,N0000007553, Benzophenones,N0000007552, Phenylacetates,N0000007551, Benzomorphans,N0000007550, Phenyl Ethers, ...
Tonabersat is a novel benzopyran compound that markedly reduces cortical spreading depression (CSD) and CSD-associated events ...
Benzopyrans D3.438.150 D3.633.100.150 Benzopyrene Hydroxylase D8.244.453.40.110 D8.244.453.05.110 D8.811.682.690.708.170.40.110 ...
Compounds with a core of fused benzo-pyran rings.. Terms. Benzopyrans Preferred Term Term UI T004570. Date01/01/1999. ... Compounds with a core of fused benzo-pyran rings.. Entry Term(s). Benzopyran Chromene Chromenes Registry Number. 0. Public MeSH ... Benzopyran Term UI T000997125. Date11/18/2019. LexicalTag NON. ThesaurusID NLM (2021). ... Benzopyrans Preferred Concept UI. M0002367. Registry Number. 0. Scope Note. ...
Compounds with a core of fused benzo-pyran rings.. Terms. Benzopyrans Preferred Term Term UI T004570. Date01/01/1999. ... Compounds with a core of fused benzo-pyran rings.. Entry Term(s). Benzopyran Chromene Chromenes Registry Number. 0. Public MeSH ... Benzopyran Term UI T000997125. Date11/18/2019. LexicalTag NON. ThesaurusID NLM (2021). ... Benzopyrans Preferred Concept UI. M0002367. Registry Number. 0. Scope Note. ...
4S)-7,8-difluoro-3,4-dihydro-2H-1-benzopyran-4-amine ...
Benzopyrans (1969-1974). Indenes (1973-1974). Public MeSH Note:. 91; was see under BENZOPYRANS 1975-90. ...
Benzopyran (substance) {424563009 , SNOMED-CT } Parent/Child (Relationship Type) Chroman derivative (substance) {424380009 , ...
... benzo benzopyran,benzopyran benzotetronique,benzotetronique beta,beta biphenyl,biphenyl biphotonique,biphotonique blood,blood ...
  • 2-amino-4H-benzopyran derivatives have received considerable attention due to their valuable biological and medicinal properties such as anticoagulant, antispasmodic, diuretic, and anti-cancer activities. (ajgreenchem.com)
  • Some benzopyrans have shown anticancerous activity in vitro. (wikipedia.org)
  • Benzopyran derivatives have strong relaxing activity on blood vessels, cardiac muscles, and smooth muscles. (ajgreenchem.com)