Distinctive neoplastic disorders of histiocytes. Included are malignant neoplasms of MACROPHAGES and DENDRITIC CELLS.
A plant genus of the family CLUSIACEAE. Members contain XANTHONES.
A plant family of the order Myrtales, subclass Rosidae, class Magnoliopsida. They are mainly trees and shrubs. Many members contain mucilage and COUMARINS.
Biologically active molecules which are covalently bound to the enzymes or binding proteins normally acting on them. Binding occurs due to activation of the label by ultraviolet light. These labels are used primarily to identify binding sites on proteins.
Experiments designed to determine the potential toxic effects of a long-term exposure to a chemical or chemicals.
The mangosteen plant family (sometimes classified as Guttiferae; also known as Hypericaceae) of the order THEALES, subclass Dilleniidae, class Magnoliopsida. It includes trees and shrubs with resinous, sticky sap, usually with broad-ended, oblong, leathery leaves with a strong, central vein, flowers with many stamens.
A plant genus of the family MYRTACEAE that bears an edible fruit and contains guavin B and quercetin glycosides.
OXADIAZOLES bearing an oxygen at the 5-position. They are mesoionic, with delocalized positive and negative charges.
Drugs that are pharmacologically inactive but when exposed to ultraviolet radiation or sunlight are converted to their active metabolite to produce a beneficial reaction affecting the diseased tissue. These compounds can be administered topically or systemically and have been used therapeutically to treat psoriasis and various types of neoplasms.
Compounds based on acridone, which have three linear rings, with the center ring containing a ring nitrogen and a keto oxygen opposite to each other. Many of them are naturally occurring alkaloids.
Tests to experimentally measure the tumor-producing/cancer cell-producing potency of an agent by administering the agent (e.g., benzanthracenes) and observing the quantity of tumors or the cell transformation developed over a given period of time. The carcinogenicity value is usually measured as milligrams of agent administered per tumor developed. Though this test differs from the DNA-repair and bacterial microsome MUTAGENICITY TESTS, researchers often attempt to correlate the finding of carcinogenicity values and mutagenicity values.
Any compound that contains a constituent sugar, in which the hydroxyl group attached to the first carbon is substituted by an alcoholic, phenolic, or other group. They are named specifically for the sugar contained, such as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc. Upon hydrolysis, a sugar and nonsugar component (aglycone) are formed. (From Dorland, 28th ed; From Miall's Dictionary of Chemistry, 5th ed)
Enzymes that catalyze the joining of two molecules by the formation of a carbon-carbon bond. These are the carboxylating enzymes and are mostly biotinyl-proteins. EC 6.4.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
Chemical or physical agents that protect the skin from sunburn and erythema by absorbing or blocking ultraviolet radiation.
Substances intended to be applied to the human body for cleansing, beautifying, promoting attractiveness, or altering the appearance without affecting the body's structure or functions. Included in this definition are skin creams, lotions, perfumes, lipsticks, fingernail polishes, eye and facial makeup preparations, permanent waves, hair colors, toothpastes, and deodorants, as well as any material intended for use as a component of a cosmetic product. (U.S. Food & Drug Administration Center for Food Safety & Applied Nutrition Office of Cosmetics Fact Sheet (web page) Feb 1995)
The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
Procedures for the improvement or enhancement of the appearance of the visible parts of the body.
The process of aging due to changes in the structure and elasticity of the skin over time. It may be a part of physiological aging or it may be due to the effects of ultraviolet radiation, usually through exposure to sunlight.
Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.
A substance, extract, or preparation for diffusing or imparting an agreeable or attractive smell, especially a fluid containing fragrant natural oils extracted from flowers, woods, etc., or similar synthetic oils. (Random House Unabridged Dictionary, 2d ed)
Substances added to foods and medicine to improve the quality of taste.
The highest dosage administered that does not produce toxic effects.
An agent that causes the production of physical defects in the developing embryo.
An alkylating sulfhydryl reagent. Its actions are similar to those of iodoacetate.
The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.
Freedom from exposure to danger and protection from the occurrence or risk of injury or loss. It suggests optimal precautions in the workplace, on the street, in the home, etc., and includes personal safety as well as the safety of property.
Iodinated derivatives of acetic acid. Iodoacetates are commonly used as alkylating sulfhydryl reagents and enzyme inhibitors in biochemical research.
Unforeseen occurrences, especially injuries in the course of work-related activities.
Exploitation through misrepresentation of the facts or concealment of the purposes of the exploiter.
Drugs manufactured and sold with the intent to misrepresent its origin, authenticity, chemical composition, and or efficacy. Counterfeit drugs may contain inappropriate quantities of ingredients not listed on the label or package. In order to further deceive the consumer, the packaging, container, or labeling, may be inaccurate, incorrect, or fake.
A hybrid separation technique combining both chromatographic and electrophoretic separation principles. While the method was invented to separate neutral species, it can also be applied to charged molecules such as small peptides.
A highly-sensitive (in the picomolar range, which is 10,000-fold more sensitive than conventional electrophoresis) and efficient technique that allows separation of PROTEINS; NUCLEIC ACIDS; and CARBOHYDRATES. (Segen, Dictionary of Modern Medicine, 1992)
Containers, packaging, and packaging materials for processed and raw foods and beverages. It includes packaging intended to be used for storage and also used for preparation of foods such as microwave food containers versus COOKING AND EATING UTENSILS. Packaging materials may be intended for food contact or designated non-contact, for example, shipping containers. FOOD LABELING is also available.
A phenethylamine that is an isomer of EPHEDRINE which has less central nervous system effects and usage is mainly for respiratory tract decongestion.
Eight-carbon saturated hydrocarbon group of the methane series. Include isomers and derivatives.
An anionic surfactant, usually a mixture of sodium alkyl sulfates, mainly the lauryl; lowers surface tension of aqueous solutions; used as fat emulsifier, wetting agent, detergent in cosmetics, pharmaceuticals and toothpastes; also as research tool in protein biochemistry.

Solid-phase microextraction and GC-ECD of benzophenones for detection of benzodiazepines in urine. (1/275)

Benzodiazepines are common drugs that cause intoxication. Benzodiazepines and their metabolites can be converted by hydrolysis in acid to the corresponding benzophenones, which are easier to be separated from matrices because of their hydrophobic properties. In this study, a new separation technique called solid-phase microextraction (SPME), which can integrate extraction, concentration, sampling and sample introduction into one single procedure, has been employed to extract the products of benzodiazepines from urine after acid hydrolysis. The extracts were determined by gas chromatography with electron-capture detection (GC-ECD). The hydrolysis conditions were optimized by a statistic orthogonal design. Factors influencing direct-immersion (DI)-SPME process were also checked and chosen experimentally. The method was evaluated with spiked human urine samples. The recoveries of nine benzodiazepines ranged from 1 to 25%, with the highest for oxazolam and the lowest for bromazepam. The calibration curves were linear from 10 to 500 ng/mL for oxazolam, haloxazolam, flunitrazepam, nimetazepam, and clonazepam and from 20 to 1000 ng/mL for the others except bromazepam. The detection limits were 2-20 ng/mL for most drugs tested. The intraday and interday coefficients of variation of the developed method were within 10 and 17%, respectively. In addition, the utility of the method was confirmed by determining two ingested benzodiazepines (flunitrazepam and oxazolam) in a volunteer's urine; urine flunitrazepam was still detectable 32 h after a therapeutic dose (1.2 mg) of the drug. Finally, the DI-SPME was compared with the conventional liquid-liquid extraction with regard to detection limits and extraction efficiency of the analytes. By DI-SPME, more amounts of analytes could be introduced into GC column than by conventional liquid-liquid extraction, and thus lower detection limits of the analytes were reached, although benzophenone recoveries by DI-SPME were rather low.  (+info)

Mechanism of regulation of hsp70 chaperones by DnaJ cochaperones. (2/275)

Hsp70 chaperones assist a large variety of protein folding processes within the entire lifespan of proteins. Central to these activities is the regulation of Hsp70 by DnaJ cochaperones. DnaJ stimulates Hsp70 to hydrolyze ATP, a key step that closes its substrate-binding cavity and thus allows stable binding of substrate. We show that DnaJ stimulates ATP hydrolysis by Escherichia coli Hsp70, DnaK, very efficiently to >1000-fold, but only if present at high (micromolar) concentration. In contrast, the chaperone activity of DnaK in luciferase refolding was maximal at several hundredfold lower concentration of DnaJ. However, DnaJ was capable of maximally stimulating the DnaK ATPase even at this low concentration, provided that protein substrate was present, indicating synergistic action of DnaJ and substrate. Peptide substrates were poorly effective in this synergistic action. DnaJ action required binding of protein substrates to the central hydrophobic pocket of the substrate-binding cavity of DnaK, as evidenced by the reduced ability of DnaJ to stimulate ATP hydrolysis by a DnaK mutant with defects in substrate binding. At high concentrations, DnaJ itself served as substrate for DnaK in a process considered to be unphysiological. Mutant analysis furthermore revealed that DnaJ-mediated stimulation of ATP hydrolysis requires communication between the ATPase and substrate-binding domains of DnaK. This mechanism thus allows DnaJ to tightly couple ATP hydrolysis by DnaK with substrate binding and to avoid jamming of the DnaK chaperone with peptides. It probably is conserved among Hsp70 family members and is proposed to account for their functional diversity.  (+info)

Comparison of the potassium channel openers, WAY-133537, ZD6169, and celikalim on isolated bladder tissue and In vivo bladder instability in rat. (3/275)

The effects of the ATP-dependent potassium channel agonists ZD6169, celikalim, and WAY-133537 on bladder contractile function were examined in vitro on isolated bladder strips and in vivo on spontaneous bladder contractions. All three compounds produced a concentration-dependent relaxation of isolated rat detrusor strips (IC50 values = 0.93, 0.03, and 0.09 microM, respectively for ZD6169, celikalim, and WAY-133537. Contractile inhibition by all three compounds was fully reversed by 6 microM glyburide. These compounds also effectively inhibited spontaneous bladder contractions in the rat hypertrophied bladder model of detrusor instability. We also examined the electrophysiological properties of WAY-133537 on isolated rat bladder detrusor myocytes. Myocytes had an average resting membrane potential of -40 mV. Under patch current-clamp conditions, WAY-133537 (0.3 and 1.0 microM, n = 4-5) produced a significant hyperpolarization of 21 and 26 mV, respectively. Hyperpolarization was reversed by the addition of 5 microM glyburide. In patch voltage-clamp studies, WAY-133537 (0.3 microM, n = 3) significantly increased outward current in response to both voltage step and ramp protocols consistent with activation of the ATP-dependent potassium channel. In the detrusor instability model, WAY-133537 and celikalim had similar oral potencies (ED50 = 0.13 and 0.3 mg/kg, respectively), whereas ZD6169 was less potent (ED50 = 2.4 mg/kg). The antihypertensive agent celikalim exerted effects on the bladder at doses that significantly reduced systemic blood pressure. In contrast, both WAY-133537 and ZD6169 inhibited bladder hyperactivity at doses that produced minimal changes in both mean arterial blood pressure and heart rate. These data suggest that both WAY-133537 and ZD6169 may be useful in the treatment of bladder instability at doses associated with minimal hemodynamic side effects.  (+info)

Guanosine triphosphatase stimulation of oncogenic Ras mutants. (4/275)

Interest in the guanosine triphosphatase (GTPase) reaction of Ras as a molecular drug target stems from the observation that, in a large number of human tumors, Ras is characteristically mutated at codons 12 or 61, more rarely 13. Impaired GTPase activity, even in the presence of GTPase activating proteins, has been found to be the biochemical reason behind the oncogenicity of most Gly12/Gln61 mutations, thus preventing Ras from being switched off. Therefore, these oncogenic Ras mutants remain constitutively activated and contribute to the neoplastic phenotype of tumor cells. Here, we show that the guanosine 5'-triphosphate (GTP) analogue diaminobenzophenone-phosphoroamidate-GTP (DABP-GTP) is hydrolyzed by wild-type Ras but more efficiently by frequently occurring oncogenic Ras mutants, to yield guanosine 5'-diphosphate-bound inactive Ras and DABP-Pi. The reaction is independent of the presence of Gln61 and is most dramatically enhanced with Gly12 mutants. Thus, the defective GTPase reaction of the oncogenic Ras mutants can be rescued by using DABP-GTP instead of GTP, arguing that the GTPase switch of Ras is not irreversibly damaged. An exocyclic aromatic amino group of DABP-GTP is critical for the reaction and bypasses the putative rate-limiting step of the intrinsic Ras GTPase reaction. The crystal structures of Ras-bound DABP-beta,gamma-imido-GTP show a disordered switch I and identify the Gly12/Gly13 region as the hydrophobic patch to accommodate the DABP-moiety. The biochemical and structural studies help to define the requirements for the design of anti-Ras drugs aimed at the blocked GTPase reaction.  (+info)

The binding site for an inhibitor of squalene:hopene cyclase determined using photoaffinity labeling and molecular modeling. (5/275)

BACKGROUND: The squalene:hopene cyclases (SHCs) are bacterial enzymes that convert squalene into hopanoids, a function analogous to the action of oxidosqualene cyclases (OSCs) in eukaryotic steroid and triterpenoid biosynthesis. We have identified the binding site for a selective, potent, photoactivatable inhibitor of an SHC. RESULTS: SHC from Alicyclobacillus acidocaldarius was specifically labeled by [3H]Ro48-8071, a benzophenone-containing hypocholesteremic drug. Edman degradation of a peptide fragment of covalently modified SHC confirmed that Ala44 was specifically modified. Molecular modeling, using X-ray-derived protein coordinates and a single point constraint for the inhibitor, suggested several geometries by which Ro48-8071 could occupy the active site. CONCLUSIONS: A covalent complex of a potent inhibitor with a squalene cyclase has been characterized. The amino acid modification and molecular modeling suggest that Ro48-8071 binds at the junction between the central cavity and substrate entry channel, therefore inhibiting access of the substrate to the active site.  (+info)

A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat. (6/275)

The discovery that peroxisome proliferator-activated receptor (PPAR)-gamma was the molecular target of the thiazolidinedione class of antidiabetic agents suggested a key role for PPAR-gamma in the regulation of carbohydrate and lipid metabolism. Through the use of high-throughput biochemical assays, GW1929, a novel N-aryl tyrosine activator of human PPAR-gamma, was identified. Chronic oral administration of GW1929 or troglitazone to Zucker diabetic fatty (ZDF) rats resulted in dose-dependent decreases in daily glucose, free fatty acid, and triglyceride exposure compared with pretreatment values, as well as significant decreases in glycosylated hemoglobin. Whole body insulin sensitivity, as determined by the euglycemic-hyperinsulinemic clamp technique, was significantly increased in treated animals. Comparison of the magnitude of glucose lowering as a function of serum drug concentrations showed that GW1929 was 2 orders of magnitude more potent than troglitazone in vivo. These data were consistent with the relative in vitro potencies of GW1929 and troglitazone. Isolated perfused pancreas studies performed at the end of the study confirmed that pancreata from vehicle-treated rats showed no increase in insulin secretion in response to a step change in glucose from 3 to 10 mmol/l. In contrast, pancreata from animals treated with GW1929 showed a first- and second-phase insulin secretion pattern. Consistent with the functional data from the perfusion experiments, animals treated with the PPAR-gamma agonist had more normal islet architecture with preserved insulin staining compared with vehicle-treated ZDF rats. This is the first demonstration of in vivo efficacy of a novel nonthiazolidinedione identified as a high-affinity ligand for human PPAR-gamma. The increased potency of GW1929 compared with troglitazone both in vitro and in vivo may translate into improved clinical efficacy when used as monotherapy in type 2 diabetic patients. In addition, the significant improvement in daily meal tolerance may impact cardiovascular risk factor management in these patients.  (+info)

Effects of ZD6169, a K(ATP) channel opener, on the micturition reflex in the rat. (7/275)

The effects of ZD6169, a new ATP-sensitive potassium channel opener, on reflex urinary bladder activity were evaluated in urethane-anesthetized female Wistar rats. Continuous transvesical slow infusion cystometrograms (0.04 ml/min) were performed in untreated, capsaicin-pretreated (125 mg/kg s.c., 4 days before experiments) and capsaicin vehicle-pretreated rats. Intravesical infusion of ZD6169 in concentrations of 6, 15, 30, and 300 nM for 2 h at each concentration increased the intercontraction interval and pressure threshold for voiding in a concentration-dependent manner in untreated and vehicle-pretreated rats but not in capsaicin-pretreated animals. The effects appeared within 30 min after administration. ZD6169 did not alter baseline bladder pressure, duration of contractions, or the peak pressure during voiding. Glibenclamide (20 mg/kg i.v.) reversed the effects of ZD6169 (30 nM). During transvesical cystometrograms performed at a fast rate (0.21 ml/min), ZD6169 in concentrations between 6 and 300 nM did not alter the intercontraction interval or pressure threshold for voiding. ZD6169 produced smaller and more variable effects during slow transurethral cystometrograms. Capsaicin, a C-fiber afferent neurotoxin, administered s.c. 4 days before the experiment, produced similar changes and also eliminated the effect of ZD6169. These data suggest that ZD6169 raises the threshold for activation of C-fiber mechanoreceptors in the bladder wall and thereby increases the bladder volume for inducing reflex voiding.  (+info)

Differential and selective inhibition of protein kinase A and protein kinase C in intact cells by balanol congeners. (8/275)

The fungal metabolite balanol is a potent inhibitor of protein kinase A (PKA) and protein kinase C (PKC) in vitro that acts by competing with ATP for binding (K(i) approximately 4 nM); congeners of balanol show specificity for PKA over PKC. We have characterized the effects of balanol and 10"-deoxybalanol in intact cells to determine whether these compounds cross the cell membrane and whether the potency and specificity noted in vitro are preserved in vivo. In neonatal rat myocytes and cultured A431 cells transiently transfected with a cyclic AMP response element-luciferase reporter construct, balanol inhibits the induction of luciferase activity by isoproterenol, indicating inhibition of PKA. Western analysis shows that both balanol and 10"-deoxybalanol reduce phosphorylation of cAMP response element-binding protein in isoproterenol-stimulated A431 cells; inhibition is concentration dependent with an IC(50) value of approximately 3 microM. Balanol, but not 10"-deoxybalanol, inhibits phosphorylation of the myristoylated alanine-rich C kinase substrate protein, a PKC substrate, in phorbol ester-stimulated A431 cells (IC(50) approximately 7 microM). Our data demonstrate that balanol is a potent inhibitor of PKA and PKC in several whole-cell systems and causes no obvious toxicity. In addition, balanol congeners inhibit PKA and PKC with the specificity and potency predicted by in vitro experiments.  (+info)

The structure of 3,3-dibromobenzophenone has been reinvestigated using new three-dimensional data. Crystals of 3,3-dibromobenzophenone are orthorhombic: a=4.05, b=11·74, c=24.80 Å , Z=4, space group Pbcn. The structure has been refined by three-dimensional methods, including anisotropic full-matrix least squares, to an R index 0.104. The conformation of isolated molecules of benzophenone, pp-dimethoxy benzophenone and 3,3-dibromobenzophenone have been calculated by semi-empirical methods, and the results are compared with those obtained from X-ray crystallographic investigations on these compounds. It has been found that the calculated geometries of isolated molecules of benzophenone and its derivatives are different from those observed in the crystal structures of these compounds. ...
Recent evidence suggests that prepulse inhibition (PPI) levels relate to executive function possibly by a prefrontal cortex (PFC) dopamine (DA) link. We explored the effects of enhanced PFC DA signaling by the nonstimulant catechol-O-methyltransferase (COMT) inhibitor tolcapone, on PPI and working memory of subjects homozygous for the Val (low PFC DA) and the Met (high PFC DA) alleles of the COMT Val158Met polymorphism. Twelve Val/Val and eleven Met/Met healthy male subjects entered the study. Tolcapone 200 mg was administered in two weekly sessions, according to a balanced, crossover, double-blind, placebo-controlled design. PPI was assessed with 5 dB and 15 dB above background prepulses, at 30-, 60-, and 120 ms prepulse-pulse intervals. Subjects also underwent the n-back and the letter-number sequencing (LNS) tasks. PPI was lower in the Val/Val compared to the Met/Met group in the placebo condition. Tolcapone increased PPI significantly in the Val/Val group and tended to have the opposite effect in
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The present study confirms and extends previous findings28 29 that tolcapone enhances the efficacy of levodopa. Whereas initial studies were focused on single dose6 or short term (one to six weeks) multiple dose22 26 coadministration of tolcapone with levodopa/decarboxylase inhibitor, the present study showed that multiple dose (tid) treatment with tolcapone results in reduced severity of wearing off type motor fluctuations in levodopa treated patients for three months and that this response is maintained over time.. Treatment with tolcapone significantly decreased mean off time (by ,20%) and increased mean on time (by ,25%), compared with placebo. Analysis of primary end point on/off data disclosed that both tolcapone dosages were equally effective in increasing on time, but the 100 mg tid dosage was more effective in decreasing off time. However, the mean reduction in levodopa dosage by month 3 was greater with 200 mg tolcapone tid than with 100 mg tid This reduction was maintained ...
The hydrogen abstraction reaction of benzophenones in micellar interiors was studied by the effect of a short, resonant microwave pulse on the recombination kinetics under magnetic fields of approximately 0.3 T. This technique allows all the significant rate constants in the reaction to be determined, in particular the singlet state recombination rate constant, which is very difficult to accurately determine by other techniques. This is determined to be 1.90 × 107 s-1 for benzophenone (BP) and 1.83 × 107 s-1 for decafluorobenzophenone in sodium dodecyl sulfate (SDS) micelles, indicating that this value is not limited by the rate of spin mixing, and thus that the kinetic approach used is justified. It also indicates that recombination is limited by re-encounter frequency and is not dependent upon substitution in the ketyl radical. All kinetic parameters are extracted for each system using a combination of single pulse and pulse shift measurements. Data are also presented for the reactions of BP ...
Benzophenone occurs naturally in some fruits and is used commercially as a perfumery and flavoring ingredient. This study was performed in response to the potential for human exposure and the lack of pertinent developmental toxicity data. Dose selection was based on a screening study in which Sprague-Dawley-derived (CD) rats were treated by gavage with benzophenone (0, 25, 50, 100, 200, or 300 mg/kg body weight/day) on gestational days 6 through 19 (NTP, 1998b). Maternal toxicity was found at all doses, but evidence of developmental toxicity was limited to a 6-8% decrease for average fetal body weight per litter (not statistically significant) at the high dose. In this study, benzophenone (100, 200, or 300 mg/kg/day) or its vehicle (0.5% methylcellulose) was administered to female CD rats by gavage on gd 6 through 19. The dose volume was 5 ml/kg. Twenty-five to 26 timed-mated rats were assigned to each group. Dams were monitored at regular intervals throughout gestation for clinical signs, feed ...
Product Details of 2-benzoyl-5-methoxy-1-phenol-4-sulfonic acid CAS 4065-45-6 BP-4. 2-Hydroxy-4-Methoxy Benzophenone-5-Sulfonic acid, 2-benzoyl-5-methoxy-1-phenol-4-sulfonic acid CAS 4065-45-6 BP-4. 2-Hydroxy-4-Methoxy Benzophenone-5-Sulfonic acid from China manufacturer on Hisupplier.com.
The photochemistry of N-methyllutidone, which is a model compound of pyrimidine bases, is investigated. When N-methyllutidone is irradiated with ultravioletlight (λ<300nm) in acetonitrile with benzophenone, four products are formed. Three of the photoproducts are separated by column chromatography and characterized by spectroscopic methods and comparing with authentic sample. Three photoproducts are N-(benzhydrylmethyl) lutidone, N-(4-benzoylbenzyl) lutidone, and lutidone, with quantum yiels of $5.07\times10^{-3}$, $1.43\times10^{-3}$, $1.84\times10^{-3}$ respectively. Three photoproducts are proposed to be formed through the reaction of two free radicals, which are originated from the photochemical hydrogen atom abstraction by benzophenone from N-methyllutidone. Benzophenone is not functioning as a photosensitizer for the photoreaction of N-methyllutidone. The luminescence of N-methyllutidone in ethanol at 77˚k is studied. No fluorescence is observed but strong phosphorescence is observed. ...
We report the observation and detailed analysis of optically-detected magnetic resonance (ODMR), radio frequency (RF) saturated ODMR and electron-nuclear double resonance (ENDOR) spectra of the lowest $^{3}(n\pi^{*})$ state of oxygen-17 labelled benzophenone ($^{17}O$-BP) in zero-field (zf). The experiments were performed at 1.4K on a single crystal sample of 4,4^{\prime}-dibromidiphenylether (DDE) containing 0.1 mol % of an isotopically-enriched guest ($^{17}O$-BP; 11.3%). Allowed transitions and forbidden transitions were assigned from low power ODMR spectra and RF saturated ODMR spectra respectively. These assignments were confirmed by ENDOR experiments. The hyperfine coupling constants and nuclear quadrupole coupling constants ($e^{2}$qQ and $\eta$) were obtained for the $^{17}O$ atom. The data indicate that (1) the n electron is highly localized on the oxygen atom in $^{3}(n\pi^{*})$ benzophenone, (2) the higher order hyperfine interaction is important due to large hyperfine coupling ...
Oxybenzone (2-hydroxy-4-methoxyphenone, benzophenone-3) is one of the UV filters commonly found in sunscreens. Its presence in swimming pools and its reactivity with chlorine has already been demonstrated but never in seawater swirnrning pools. In these pools, chlorine added for disinfection results in the formation of bromine, due to the high levels of bromide in seawater, and leads to the formation of brominated disinfection byproducts, known to be more toxic than chlorinated ones. Therefore, it seems important to determine the transformation products of oxybenzone in chlorinated seawater swimming pools; especially that users of seawater swimming pools may apply sunscreens and other personal-care products containing oxybenzone before going to pools. This leads to the introduction of oxybenzone to pools, where it reacts with bromine. For this purpose, the reactivity of oxybenzone has been examined as a function of chlorine dose and temperature in artificial seawater to assess its potential to ...
Benzophenone-3 (BP-3; oxybenzone) is an ingredient in sunscreen lotions and personal-care products that protects against the damaging effects of ultraviole
Tolcapone (brand name Tasmar) is a drug used to treat Parkinsons disease (PD). It is a selective, potent and reversible nitrocatechol-type inhibitor of the enzyme catechol-O-methyltransferase (COMT). It has demonstrated significant liver toxicity, which has led to suspension of marketing authorisations in a number of countries. In comparison with entacapone, another nitrocatechol COMT inhibitor, tolcapone has a longer half life (2.9 hours vs. 0.8 hours) and can better penetrate the blood-brain barrier, acting both in the central nervous system and in the periphery. However, entacapone is less toxic for the liver. Tolcapone is used in the treatment of Parkinsons disease as an adjunct to levodopa/carbidopa or levodopa/benserazide medications. Levodopa is a prodrug for dopamine, which reduces Parkinson symptoms; carbidopa and benserazide are aromatic L-amino acid decarboxylase (AADC) inhibitors. Without administration of tolcapone, the beneficial effects of levodopa tend to wear off more quickly, ...
Catechol-O-methyltransferase (COMT) modulates dopamine levels in the prefrontal cortex. The human gene contains a polymorphism (Val158Met) that alters enzyme activity and influences PFC function. It has also been linked with cognition and anxiety, but the findings are mixed. We therefore developed a novel mouse model of altered COMT activity. The human Met allele was introduced into the native mouse COMT gene to produce COMT-Met mice, which were compared with their wild-type littermates. The model proved highly specific: COMT-Met mice had reductions in COMT abundance and activity, compared with wild-type mice, explicitly in the absence of off-target changes in the expression of other genes. Despite robust alterations in dopamine metabolism, we found only subtle changes on certain cognitive tasks under baseline conditions (eg, increased spatial novelty preference in COMT-Met mice vs wild-type mice). However, genotype differences emerged after administration of the COMT inhibitor tolcapone: performance of
Benzophenone-4-iodoacetamide | C15H12INO2 | CID 131289 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Interactions of benzophenone (BP) with the Torpedo nicotinic acetylcholine receptor (nAChR) were characterized by electrophysiological analyses, radioligand binding assays, and photolabeling of nAChR-rich membranes with [3H]BP to identify the amino acids contributing to its binding sites. BP acted as a low potency noncompetitive antagonist, reversibly inhibiting the ACh responses of nAChRs expressed in Xenopus oocytes (IC50 = 600 卩 and the binding of the noncompetitive antagonist [3H]tetracaine to nAChR-rich membranes (IC50 = 150 卩. UV irradiation at 365 nm resulted in covalent incorporation of [3H]BP into the nAChR subunits (d , a ߠ, ?), with photoincorporation limited to the nAChR transmembrane domain. Comparison of nAChR photolabeling in the closed state (absence of agonist) and desensitized state (equilibrated with agonist) revealed selective desensitized state labeling in the d subunit of dPhe-232 in dM1 and dPro-286/dIle-288 near the beginning of dM3 that are within a pocket at the ...
A series of substituted benzophenone analogues has been synthesized and evaluated as orally active anti-inflammatory agents with reduced side effects. The anti-
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INDOFINE Chemical Company supplies 4-(N,N-DIMETHYLAMINO)BENZOPHENONE for pharmaceutical, agricultural and life science industries. We provide CAS MSDS, Certificate of analysis references.
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McMurry reactions of (η5-acetylcyclopentadienyl) cobalt-(η4-tetraphenylcyclobutadiene) with benzophenone: ketone couplings and a pinacol/pinacolone rearrangement Conference Paper ...
Creative-Proteomics offer cas 119-61-9 BENZOPHENONE UNLABELED 100 UG/ML IN NONANE. We are specialized in manufacturing Stabel Isotope Labeled Analytical Standard products.
Sigma-Aldrich offers Aldrich-454168, 4-Fluoro-4′-(phenylethynyl)benzophenone for your research needs. Find product specific information including CAS, MSDS, protocols and references.
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Naveen, P. and Rekha, N. D. and Lakshmi Ranganatha, V. and Bushra Begum, A. and Shaukath Ara Khanum, (2017) Synthesis of salicylic acid fused dihydropyrazole analogues and their mechanism of action on escherichia coli cells. Der Pharma Chemica, 9 (16). pp. 91-97. ISSN 0975-413X Shamanth Neralagundi, H. G. and Bushra Begum, A. and Prabhakar, B. T. and Khanum, Shaukath Ara (2016) Design and synthesis of diamide-coupled benzophenones as potential anticancer agents. European Journal of Medicinal Chemistry, 115. pp. 342-351. ISSN 0223-5234 Zabiulla, and Naveen, S. and Bushra Begum, A. and Khanum, Shaukath Ara and Lokanath, N. K. (2016) Structural studies of a novel bioactive benzophenone derivative: (4-Chloro-2-hydroxy-phenyl)-phenyl-methanone. Molecular Crystals and Liquid Crystals, 625 (1). pp. 233-237. ISSN 1542-1406 Mohammed, Al-Ghorbani and Bushra Begum , A. and Mamatha Zabiulla, S. V. and Shaukath Ara Khanum, (2015) Piperazine and Morpholine: SyntheticpPreview and pharmaceutical applications. ...
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Tolcapone; Tolcapone may be used in COMT-mediated cell signaling studies. Tolcapone has been used in methyltransferase assay in human embryonic kidney 293 cells.
By limiting your sunscreen choices to ones that contain the 3 essentials, youll still have quite a few options. To find a sunscreen thats right for you, youll want to consider your skins unique needs and where you want to apply the sunscreen.. The following list can help you narrow your options so that you can find a sunscreen thats right for you.. Acne-prone skin: Look for the words non-comedogenic or wont clog pores.. Allergy-prone skin: Avoid sunscreen that contains fragrance, PABA, parabens, or oxybenzone (benzophenone-2, benzophenone-3, diosybenzone, mexenone, sulisobenzone, or sulisobenzone sodium).. Around your eyes: To prevent sunscreen from dripping into your eyes, use a sunscreen stick around your eyes. Make sure the stick has an SPF 30 (or higher), broad-spectrum protection, and water resistance.. Children: Use a sunscreen made for children. Most contain zinc oxide and titanium dioxide.. Dry skin: Look for moisturizing or dry skin on the label.. Lips: Lip balm with SPF ...
In an appropriate sized vessel, weigh out the water and the Carbopol Ultrez-21. Allow the Carbopol Ultrez-21 to completely hydrate without mixing. Once the hydration is completed, begin mixing the batch. Add the Drieline, MDI Complex, alpha-Bisabolol, Wacker Belsil DMC6031, VitaCon AEM, SilSense A-23 and Merguard 1190 while mixing the batch. Continue mixing until uniform. In a separate vessel, prepare the sunscreen pre-blend by combining the SD 40B Alcohol, Hallbrite OS, EI OMC, Benzophenone-3, Floramac 10 and Fragrance. Mix this pre-blend until all of the Benzophenone-3 has dissolved and the blend is uniform. Add the sunscreen pre-blend to the batch with mixing. Mix the batch until it is uniform. Add the TEA to the batch with mixing. Once the batch is uniform, add the Merquat 3330 and mix the batch until uniform ...
EWGs Skin Deep® database gives you practical solutions to protect yourself and your family from everyday exposures to chemicals in personal care products.
EWGs Skin Deep® database gives you practical solutions to protect yourself and your family from everyday exposures to chemicals in personal care products.
In this research intermolecular and intramolecular triplet sensitization has been employed to photochemically generate triplet alkyl nitrene intermediates in solution. Photolyzing with light greater than 300 nm assures that only the ketone chromophore is exclusively excited to its triplet excited state. Once generated, the ketone can transfer its triplet energy to the azide moiety which loses molecular nitrogen to give a triplet alkyl nitrene intermediate. Intermolecular triplet sensitization in solution allowed trapping of triplet alkyl nitrene intermediates via bimolecular reactions. Photolysis of 1-azidoadamantane in solution with acetophenone, benzophenone and acetone led to an azo-dimer as the major product. This product comes from dimerization of two triplet alkyl nitrenes. Intermolecular sensitized photolysis of benzyl azide led to N-methyleneaniline as the major photoproduct with acetophenone as the triplet sensitizer. With benzophenone as the triplet sensitizer the major product was ...
Pharmaceutical Raw Material Ultraviolet absorbent UV-531 CAS: 1843-05-6 Basic Info. Name:Ultraviolet absorbent UV-531 Synonym: OCTABENZONE 2-HYDROXY-4-OCTYLOXY BENZOPHENONE BP-12 UV-531 2-HYDROXY-4-N-OCTOXY BENZOPHENONE UV ABOSORBER 531...
Dose: PRELIM: Rat: iv: 2.5 mg/kg, gavage: 2.5 and 10 mg/kg mice: iv: 15 mg/kg, gavage: 15 and 60 mg/kg TK study: feed: 312 & 1250ppm for both; iv: 2.5 mg/kg(rat), 15mg/kg(mouse); and gavage: 2.5, 5, 10 mg/kg(rat) and 15, 30, 60mg/kg(mouse ...
4] a ) J. T. Kauer, S. Erickson-Vitanen, H. R. Wolfe, W. F. De Grddo, J B d . Chrm. 1986.261. 10695, b) W. T. Miller, E. T. Kaiser. Proc. Nurl. Arud. Sci. U S A 1988, K S , 5429. c) T. Tao. C. J. Schemer, M. Lamkin. 5io~liemistr.v 1986.2.7. 7633. [5] a ) R. Breslow, Acr. Chrm. Res. 1980, 13, 170, b) C . Helene, Phofochem. Pholohiol. 1972, 16. 519. [6] G. W. Anderson, J. E. Zimmerman. F. M. Gallahan, J. Am. Cheni. Sor. 1964. K6. 1839. [7] A section of a silica substrate bearing nitroveratryloxycarbonyl(NV0C)protected amino groups was photodeprotected [3] and then derivatized uith the NHS ester of 3-benzoylbenzoic acid. A second section of the substrate was then deprotected and derivatized with the NHS ester of biotin. Any unreacted sites in the first section (due to incomplete coupling of benzophenone) will also react with the biotin NHS ester. The entire surface was then treated with fluorescein-streptavidin (Molecular Probes lnc.. Eugene. O R (USA)). The coupling efficiency of benzophenone was ...
Sorry, this time it was me who misread your post. I thought the above was about benzoic acid + CaCO3. I dont know why you brought out Na2CO3 when the issue was about CaCO3, but in the case of benzoic acid + Na2CO3 the main products should be benzene, sodium phthalate and other byproducts, depending also on the temperature, closed/open system, O2 and H2O presence, etc.. Benzophenone forms only when the calcium salt is used where ketonization is the main pathway. In the themolysis of sodium benzoate less than 3% of conversion is accounted to the ketonization, while the themolysis of the potassium salt is even cleaner, yielding only benzene and potassium phthalate in 4.75 : 1 ratio. On the contrary, calcium benzoate yields benzene and benzophenone in a 2 : 1 ratio in a closed deareated system at 400-500°C (the formation of benzene is attributed to the presence of moisture in the starting material - obviously there is no explanation for its formation unless a proton donor is present). See: ...
Medium hold styling product with no shine. Styles and controls hair to create the look you want with a matte finish. Specially formulated with Panthenol to improve hairs health and thickness. Benzophenones enhance the products performance by shielding against environmental elements, so you get looks that last.. Application: Apply liberally to damp hair and style hair into final shape. Brush through once dry to activate matte finish.. Features: D-Panthenol, Sodium PCA, Benzophenones, Hydrolyzed Wheat Protein, Acrylates Crosspolymer-3, Silica.. Benefits: Prevents from hair damage, thickens hair and acts as a long-lasting moisturizer. Promotes moisture retention. Provides protection against the effects of ultraviolet rays and natures visible components on hair. Enhances hairs body and shine while acting as an excellent moisturizing and permanent conditioning agent. Offers medium hold, long-lasting results with humidity resistance and no flakes. Weightless, white ingredient used to achieve the ...
TY - JOUR. T1 - Dispersive triplet excitation transport in organic glasses. AU - Richert, R.. AU - Bässler, H.. PY - 1986/1/1. Y1 - 1986/1/1. N2 - Time dependent transport of triplet excitations in amorphous benzophenone, anthraquinone, and phenanthrene has been investigated in the temperature range 4.2 K,T, 100 K by monitoring diffusion-controlled decay of the inhomogeneously broadened 0-0 phosphorescence band of bulk states. The results are in excellent agreement with both the analytic theory of Grünewald et al. and computer simulation of nonequilibrium transport. They indicate the applicability of a stochastic transport model based on asymmetric hopping rates with unrestricted energy relaxation. The time dependence of the ensemble averaged hopping frequency has been determined within three decades of time. It can be approximated by a ν(t)∼(t/t0)a-1 law with time dependent dispersion parameter a.. AB - Time dependent transport of triplet excitations in amorphous benzophenone, ...
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Runoff from fire control or dilution water may cause pollution. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam. Use agent most appropriate to extinguish fire ...
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Intermolecular Reductive Coupling of Esters with Benzophenones by Low-Valent Titanium: Synthesis of Diarylmethyl Ketones Revisited
How mad to use oxybenzone Idc fps/spf 50 syrup. However Mkmen moisturizer sunscreen spf 25, or oxybenzone, has been negatively linked to serious mental complications involved when used in excess plant and for long periods often of time. Last financial year the oxybenzone has proceeded wholly won a good colonization contract for automatic packaging of thao md david. oxybenzone, therefore, contends that belief the 006 patent alone does wrong not that claim axia medical solutions llc, rather to reach the 006 patent or specification merely
Levodopa is the cornerstone of idiopathic Parkinsons disease (PD) treatment. However, after long-term use of levodopa, a significant percentage of patients experience motor fluctuations, which worsen their quality of life. Catechol-O-methyltransferase (COMT) inhibitors reduce levodopa metabolism and enhance the respective plasma levels, resulting in improvements in symptoms and overall quality of life.Tolcapone was the first drug of this class to be marketed, but was withdrawn in the European Union due to its implication in the deaths of three PD patients due to hepatic failure. Three deaths from fulminant hepatic failure in 40000 patient-years is a number that is 10-100 times higher than the expected incidence in the general population and, according to the manufacturers own information, the number is probably underestimated due to under-reporting of cases.In the US, tolcapone was not withdrawn, but restrictive liver enzyme monitoring measures were issued by authorities, which severely ...
Instructions for use: Glide a fine layer over your face as needed Can be used alone or under makeup 50ml/1.6fl.oz. Ingredients: Aqua (Water), Homosalate, Benzophenone-3, Niacinamide, Ethylhexyl Salicylate, Phenyl Trimethicone, Cetearyl Alcohol, Butyl Methoxydibenzoylmethane, Ethylhexyl Methoxycinnamate, Octocrylene, Caprylic/Capric Triglyceride, Behentrimonium Methosulfate, Divinyldimethicone/Dimethicone Copolymer, Polysilicone-15, Phenoxyethanol, Cetearyl Olivate, Sorbitan Olivate, Polyquaternium-37, Propylene Glycol Dicaprylate/Dicaprate, Spilanthes Acmella Flower Extract, Tocopheryl Acetate, Ascorbyl Tetraisopalmitate, Ethylhexylglycerin, Lactic Acid, Ppg-1 Trideceth-6, C12-13 Pareth-3, C12-13 Pareth-23, Sodium Citrate, Citric Acid, Bht
Benzophenones chemicals found in some sunscreen and nail polish has been linked to endometriosis, according to a new study.. Not surprisingly, the industry group the Personal Care Products Council faulted the study calling it weak and unconvincing, said WebMD. The study is published in Environmental Science & Technology and found that some chemicals broadly used in sunscreens, nail polish, and other consumer products-because of their UV protecting properties-are linked to increased risks for developing endometriosis.. Endometriosis is a painful gynecological condition in which uterine tissue grows outside the uterus, typically on the exterior of the uterus and into the abdomen near the ovaries or fallopian tubes. The tissue reacts as if it were within the uterus, thickening and shedding monthly with a womans menstrual cycle, explained WebMD. The condition can lead to scarring and infertility and affects about one in 10 women. Studies suggest that the condition is on the rise.. The research ...
A high percentage of cells were arrested in the G2/M phase (52%, 56%, and 59%) at time points 24, 48, and 72 h respectively, following treatment with compound 24 with a much lower percentage of cells in the G2/M phase for the sample treated with the vehicle (28%, 23%, and 24%) at the same time points. Phenstatin 7a was used as a positive control through all the biological experiments. and B rings of the benzophenone for activity, as also observed for phenstatin and analogues [67]. 3.1.2. Series 2: 1-(Aryl-(3,4,5-Trimethoxyphenyl)Methyl)-1position on one or both aryl rings (Cl, F, Br, OH, OCH3, CH3, etc). This library of compounds did not show any significant activity, with cell viability Selamectin of 67C90% at concentrations of 1 1 and 0.1 M, as observed for the Series 1 1,2,4-triazole derivatives 13bCg and lCo, indicating that the imidazole ring alone is not sufficient for antiproliferative activity. The most active compounds in this panel were identified as the 4-nitro derivative 20b and the ...
To produce C6H6 from C6H5COONa, in any case, requires a source of additional H in a reducing environment, with other possible left-behind products being Na2CO3 and HCOONa if there is cleavage from the C6 ring. In the absence of a source of additional H, probable products would instead be substances like biphenyl, C6H5-C6H5, or diphenyl ether, C6H5-O-C6H5, or benzophenone, (C6H5)2C=O, or diketobenzoin, C6H5-CO-CO-C6H5, or benzoic anhydride, C6H5-CO-O-CO-C6H5, depending on the temperature conditions and any other substances present. The last two do not involve any cleavage of the C6H5-C bond. In any case, pyrolysis of compounds like benzoates seldom results in any one pure product ...
Photochemical reactions of 2-substituted furans I, IV and V with benzaldehyde, benzophenone and 4-methylbenzophenone gave substitued 2,7-dioxabicyclo[3,2,0]-3-heptenes, which can be used for syntheses of 2,3- or 2,4-disubstituted furans. Regioisomeric (2:1)-cycloadducts XV and XVI were distinguished on the basis of their 1H and 13C NMR spectra.. ...
Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of 4‐phenylbut‐3‐en‐2‐one [07.024] and benzophenone .... ...
BACKGROUND: Catechol-O-methyltransferase (COMT) metabolizes dopamine. The COMT Val(158)Met polymorphism influences its activity, and multiple neural correlates of this genotype on dopaminergic phenotypes, especially working memory, have been reported. COMT activity can also be regulated pharmacologically by COMT inhibitors. The inverted-U relationship between cortical dopamine signaling and working memory predicts that the effects of COMT inhibition will differ according to COMT genotype. METHODS: Thirty-four COMT Met(158)Met (Met-COMT) and 33 COMT Val(158)Val (Val-COMT) men were given a single 200-mg dose of the brain-penetrant COMT inhibitor tolcapone or placebo in a randomized, double-blind, between-subjects design. They completed the N-back task of working memory and a gambling task. RESULTS: In the placebo group, Met-COMT subjects outperformed Val-COMT subjects on the 2- back, and they were more risk averse. Tolcapone had opposite effects in the two genotype groups: it worsened N-back performance
The Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene affects activity of the enzyme and influences performance and efficiency of the prefrontal cortex (PFC); however, although catecholaminergic neurotransmission is implicated, the underlying mechanisms remain elusive because studies of the role of COMT in PFC function are sparse. This study investigated the effect of tolcapone, a brain-penetrant COMT inhibitor, on a rat model of attentional set shifting, which is dependent on catecholamines and the medial PFC (mPFC). Additionally, we investigated the effect of tolcapone on extracellular catecholamines in the mPFC using microdialysis in awake rats. Tolcapone significantly and specifically improved extradimensional (ED) set shifting. Tolcapone did not affect basal extracellular catecholamines, but significantly potentiated the increase in extracellular dopamine (DA) elicited by either local administration of the depolarizing agent potassium chloride or systemic administration
S.E. Mallakpour; A. R. Hajipour and Kh. Faghihi, Eur. Polym. J. 2001, 37, 119. Microwave-Assisted Synthesis of Optically Active Poly (amide-imde)s with Benzophenone and L-Alanine Linkages. S.E. Mallakpour; A. R. Hajipour and Kh. Faghihi, Eur. Polym. J. 2001, 37, 119. Microwave-Assisted Synthesis of Optically Active Poly (amide-imde)s with Benzophenone and L-Alanine Linkages.
Mycobacterium leprae is the causative agent of the disease, leprosy. As M. leprae develops resistance against most of the drugs, novel drug targets are required in order to design new drugs. The present study is aimed at finding the active site of the protein, which is used as a strategy in drug design. Enoyl-acyl carrier protein reductase is one of the receptor proteins used in drug discovery for screening anti-leprosy agents. The crystal structure of the inhibited M. leprae InhA complex PDB ID: 2NTV provide the details of protein-ligand interactions. Series of compounds having benzophenone moiety were designed. The virtually designed drug candidates have docked well in the active site region of the protein. The prediction of ADME properties was also performed by Qikprop software ...
In 1967, Norrish and Porter were honoured with Nobel prize for their seminal work on understanding the fast chemical reactions using flash photolysis technique.1 Since then benzophenone (Bzp) serves as an archetypal system for understanding the photochemistry of various aromatic ketones. Aromatic ketones find their use in various technologically significant applications like sunscreen, photocatalysis, etc., apart from their fundamental interest.2 Efficacy of aromatic ketones for use in various applications relies upon their photophysics and photochemistry. Therefore, understanding the photophysics and photochemistry of Bzp has attracted several experimental and theoretical investigations.2 Despite these myriads of investigations, pathways for populating the lowest triplet state (T1) after photoexcitation to the S1 state remains still elusive. There are two plausible pathways: i) a direct ISC from S1(nπ*) to T1(nπ*); or ii) an indirect process, involving ISC from S1(nπ*) to T1(ππ*) with ...
Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) marketed in the US as an ophthalmic solution (current brand names Prolensa and Bromday, prior formulation brand name Xibrom, which has since been discontinued) by ISTA Pharmaceuticals for short-term, local use. Prolensa and Bromday are the once-daily formulation of bromfenac, while Xibrom was approved for twice-daily administration. In Europe, the trade name is Yellox. Bromfenac is indicated for the treatment of ocular inflammation and pain after cataract surgery. The FDA and European approvals for bromfenac are for use one day before and two weeks following cataract surgery for the treatment of ocular inflammation and pain. The drug has been shown to reduce macular edema and thickness of the retina (an indicator for inflammation) and improve visual acuity after surgery. Bromfenac is contraindicated for people with adverse reactions to NSAIDs, such as asthma or rashes. Bromfenac eye drops are generally well tolerated. Comparatively ...
Garcinia kola (Family Guttifereae) known as bitter kola is a highly valued ingredient in African traditional medicine. The plant is cultivated largely in West Africa for its edible fruit and seeds which has been employed in folk medicine as rejuvenating agent and general antidote. Bitter cola seeds have been shown to contain a complex mixture of biflavonoids, prenylated benzophenones and xanthones.. Many pharmacological effects have been demonstrated for Garcinia biflavonoids, among them are antiviral, anti-inflammatory, antidiabetic, bronchodilator, antihepatotoxic properties, other studies show that antimicrobial activity was due to polyisoprenylated benzophenone. Some proprietary dietary supplements containing Garcinia kola extractives already exist in US and African markets.. ...
The first objective of this thesis was to investigate effects of endocrine disruptors on the developing brain and gonads of bird embryos. The substances studied were the insecticide methoxychlor, and nine UV-filters (3-benzylidene camphor (3BC), 4 methyl benzylidene camphor (4MBC), benzophenone (BP) 1,2 and 3, 4 hydroxy benzophenone (4 HB), 4 dihydroxy benzophenone (4DHB), benzyl salicylate (BS), and ethyl-4-aminobenzoate Et-PABA)), commonly used in cosmetic products. Some of these substances have no estrogenic effect in vitro, but have been shown to be estrogenic in vivo. The PCB-mixture Clophen A50 is a well-known inducer of biotransformation enzymes and was co-administered with methoxychlor and the UV-filters 3BC and 4MBC.. Exposure to 3BC or 4MBC caused ovotestis formation and malformations of the Müllerian ducts in Japanese quail embryos. Co-exposure to one of these compounds and Clophen A50 enhanced the effects, indicating that Clophen A50 potentiates the effects of the UV-filters. ...
Catechol-O-methyltransferase (COMT) catabolises the catecholamine neurotransmitters and influences cognitive function. COMT modulates dopamine levels in the prefrontal cortex and its action in this region is generally invoked to explain its effects on cognition. However, its role in other brain regions important for cognitive function remains largely unexplored. Here, we investigated COMTs impact on dopamine metabolism in the hippocampus and hippocampal-dependent behaviour. We examined the acute effects of a centrally-acting COMT inhibitor, tolcapone (30 mg/kg i.p.), on dopamine metabolism in the rat dorsal hippocampus, assessed both in tissue homogenates and extracellularly, using in vivo microdialysis. Additionally, we investigated the effect of tolcapone on delayed-rewarded alternation and spatial novelty preference, behavioural tasks which are dependent on the dorsal hippocampus. Tolcapone significantly modulated dopamine metabolism in the dorsal hippocampus, as indexed by the depletion of
There are concerns that developmental exposure to endocrine disrupting chemicals such as phenolic compounds and phthalates could affect child cognitive function. Epidemiological studies tackling this question have mainly focused on phthalate metabolites and bisphenol A, but not on the other phenolic compounds. Our study aimed to assess the relationship between in-utero exposure to phthalates, bisphenol A and other phenolic compounds (parabens, triclosan, dichlorophenols and benzophenone-3) and the Intelligence Quotient (IQ) of boys at 5-6 years. In 452 mother-son dyads from the French EDEN cohort, we measured 11 phthalate metabolites and 9 phenolic compounds (4 parabens, benzophenone-3, bisphenol A, 2 dichlorophenols and triclosan) in spot urine samples collected between 22 and 29 gestational weeks. Verbal and performance IQ of children were assessed at 5-6 years by a psychologist using the Wechsler Preschool and Primary Scale of Intelligence (WPPSI). We used adjusted Structural Equation Models (SEM)
Weatherable polycarbonate compositions (formulations or blends) comprise polycarbonate, cycloaliphatic polyester resins, at least one of a benzotriazole, benzophenone, and triazine based UVA, and a catalyst quencher. The incorporation of the cycloaliphatic polyester resin and the benzotriazole, benzophenone, and triazine based UVA exhibits a synergistic effect, thereby resulting in unexpected enhanced protection of the polycarbonate compositions by imparting photostability to the polycarbonate formulations, thereby reducing yellowing or other forms of light induced degradation.
TY - JOUR. T1 - Preparation of an electrophilic glycine cation equivalent and its reaction with heteroatom nucleophiles. AU - ODonnell, Martin J.. AU - Bennett, William D.. AU - Polt, Robin L.. PY - 1985. Y1 - 1985. N2 - A variety of heteroatom substituted Schiff base amino esters 4 - 7 are prepared either from the benzophenone imine of glycine ethyl ester (3) or by reaction of acetate 4 with heteroatom nucleophiles.. AB - A variety of heteroatom substituted Schiff base amino esters 4 - 7 are prepared either from the benzophenone imine of glycine ethyl ester (3) or by reaction of acetate 4 with heteroatom nucleophiles.. UR - http://www.scopus.com/inward/record.url?scp=0000903898&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0000903898&partnerID=8YFLogxK. U2 - 10.1016/S0040-4039(00)89111-X. DO - 10.1016/S0040-4039(00)89111-X. M3 - Article. AN - SCOPUS:0000903898. VL - 26. SP - 695. EP - 698. JO - Tetrahedron Letters. JF - Tetrahedron Letters. SN - 0040-4039. IS - 6. ER - ...
A very mild-smelling solid that comes as white flakes. A good fixative for rose and other floral notes that is also very helpful in hot applications like candles and bath oils.. Arctander describes it like this: Used extensively in perfumes for sweet-woody-geranium-like notes in low-cost fragrances, soap perfumes, etc. Useful as a fixative. It has an extremely low vapor pressure at room temperature, and its effect upon the fragrance is only perceptible and apparent in mixtures with lower boiling items or at higher temperatures. ...
Ultraviolet (UV) filters are widely used in sunscreen and personal care products due to their ability to give protection to our skin from UV radiation. Oxybenzone, commonly known as benzophenone-3, is ...
Previous activity-guided phytochemical studies on Garcinia buchananii stem bark, which is traditionally used in Africa to treat various gastrointestinal and metabolic illnesses, revealed xanthones, polyisoprenylated benzophenones, flavanone-C-glycosides, biflavonoids, and/or biflavanones as bioactive key molecules. Unequivocal structure elucidation of biflavonoids and biflavanones by means of NMR spectroscopy is often complicated by the hindered rotation of the monomers around the C-C axis (atropisomerism), resulting in a high spectral complexity. In order to facilitate an unrestricted rotation, NMR spectra are usually recorded at elevated temperatures, commonly over 80 degrees C, which effects in a single set of resonance signals. However, under these conditions, one of the target compounds of this investigation, (2R,3S,2R,3R)-manniflavanone (1), undergoes degradation. Therefore, we demonstrated in the present study that the 1,1-ADEQUATE could be successfully used as a powerful alternative ...
Coppertone spray spf 15 is intensified also known by turns its drug name, oxybenzone. It would probablv be impossibly difficult to allege is that deprives someone requesting Gel bronzant hydratant fps 15 is acquiring oxybenzone tablets sold for abuse. oxybenzone reported last month exceeds that a courageous federal trial in overhearing a patent infringement case they brought by novartis against eons sonar products
Environmental phenols are a group of chemicals with widespread uses in consumer and personal care products, food and beverage processing, and in pesticides. We assessed exposure to benzophenone-3, bisphenol A (BPA), triclosan, methyl- and propyl parabens, and 2,4- and 2,5-dichlorophenol or their precursors in 506 pregnant women enrolled in the National Childrens Study (NCS) Vanguard Study. We measured the urinary concentrations of the target phenols by using online solid-phase extraction-isotope dilution high performance liquid chromatography-tandem mass spectrometry. NCS women results were compared to those of 524 similar-aged women in the National Health and Nutrition Examination Survey (NHANES) 2009-2010, and to 174 pregnant women in NHANES 2005-2010. In the NCS women, we found significant racial/ethnic differences ( ...
The occurrence of sunscreen agents and their metabolites in surface waters gives rise to public concerns. However, little is known about the environmental fate of these pollutants at present, especially for their metabolites. In this study, we investigated the photochemical of sunscreen agents and their metabolites in natural waters, adopting benzophenone-3 (BP-3) and its human metabolite 4-hydrox ...
|h1|PROLENSA OPHTHALMIC SOLUTION (BROMFENAC)|/h1| |h2|Prolensa Ophthalmic Solution Description|/h2| |p|Whether it’s the natural aging process or a medical condition, cataract surgery may be recommended by your doctor or ophthalmologist to help res
Benzophenone-3 ( Table 2 ). Male adolescents in the 3rd and 4th quartiles of BP-3 had significantly lower TT [-38.74%; 95% confidence interval (CI): -58.52%, -10.42%; and -36.87%; 95% CI: -59.34%, -1.98%, respectively, based on model 1] than males in
Product Description: Fortified with Calcium & concentrated with Pro-Vitamin B5 for moisture. Improving nail resistance & strength, whilst preventing splitting, chipping & peeling.. Directions: Apply 2 coats as a protective shield to clean, dry nails. Re-apply 1 coat each day for 3 days. Remove with Manicare Nail Polish Remover & re-apply as above until desired result is achieved.. Ingredients: Butyl Acetate, Ethyl Acetate, Nitrocellulose, Acetyl Triethyl Citrate, Isopropyl Alcohol, Phthalic Anhydride/ Trimellitic Anhydride/ Glycols Copolymer, Benzophenone-3, Acetyl Tributyl Citrate, Calcium Pantothenate, CI 47000, CI 77510. #T13232066. Safety:. Keep away from heat & flame. Keep out of reach of children.. ...
Chloé - Chloé Love Story ChloÉ Love Story erzählt eine moderne Liebesgeschichte zweier Menschen in Paris. Duftnoten Kopfnote: Neroli Basisnote: Moschus, Holz Inhalt: 30 ml Eau de Parfum Inhaltsstoffe: AQUA/WATER/EAU, ETHYLHEXYL METHOXYCINNAMATE, BUTYLPHENYL METHYLPROPIONAL, BENZYL SALICYLATE, BENZOPHENONE-3...
Juuksepalsam ilma ammoniaagi ja vesinikperoksiidita.. Kasutamine: kasuta kindaid. Loksuta korralikult ja kanna palsam ühtlaselt puhastele, kuivadele või niisketele juustele. Jäta 20-30 minutiks mõjuma. Loputa liege veega.. Ettevaatusabinõud: Juuksevärvid võivad põhjustada tõsiseid allergilisi reaktsioone. Lugege juhend läbi ja järgige seda. Toode ei ole ette nähtud kasutamiseks alla 16-aastastel lastel. musta hennaga tehtud ajutised tätoveeringud võivad suurendada allergia tekkimise ohtu. Ärge värvige juukseid, kui Teie näol on lööve või kui Teie peanahk on tundlik, ärritatud või kahjustatud; -kui Teil on kunagi pärast juuste värvimist esinenud mingeid reaktsioone; -kui Teil on varem musta hennaga tehtud ajutise tätoveeringu järgselt esinenud mingeid reaktsioone.. Koostis: Aqua, Cetearyl Alcohol, Sodium Lauryl Sulfate, Cetrimonium Chloride, Parfume, , Hexyl Cinnamal, Mangifera Indica (Mango) Fruit Extract, Aminomethyl, Propanol, Benzophenone-4, HC Red 3, HC Blue 2, ...
Instructions for use: Spray over hair when finished styling 150ml/ 5.2fl.oz. Made in France Ingredients: Alcohol Denat, Aqua, Ethyl Ester of PVM/MA Copolymer, *Polyquaternium-11,*Hydrolysed Hibiscus Esculentus Extract, Aminomethyl Propanol, *Hydrolysed Wheat Protein, Propylene Glycol, *Aloe Barbadensis Leaf Extract, *Methylheptyl Isotearate, *Parfum (Fragrance), Benzophenone-4, Limonene, Butylphenyl Methylpropional
CAS: NA | Desbromo Indol Bromfenac impurity | Buy and find out price, stock availability of high quality R&D product with data and CoA from SynThink
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Yellox - Súhrn charakteristických vlastností lieku - bromfenac sodium sesquihydrate - S01BC11 - PharmaSwiss Ceska Republika s.r.o
Conventional sunscreens have a number of ingredients that have been linked to hormone disruption in animal tests and are readily absorbed by skin. Some these ingredients include: parabens, benzophenone, homosalate and octyl-methoxycinnamate. Also, sunscreens containing nanoparticles have come under scrutiny because they may be harmful to human tissue. Nanoparticles are added because they make titanium dioxide and zinc oxide sunscreens …. ...
Skin diseases caused by sun exposure include melanoma, basal cell carcinoma, squamous cell carcinoma, photoaging, as well as sunburn and many other conditions. According to the Skin Cancer Foundation, skin cancer is the most common type of cancer in the US. The vast majority of mutations found in melanoma, according to a 2009 study published in Nature [1], are caused by UV radiation.. Currently, commercial sunscreens are composed of physical sunblocks including zinc oxide and titanium dioxide, and chemical UV (ultraviolet lights) absorbers/filters such as octinoxate for UVB and benzophenone for UVA. The compositions of commercial sunscreen products are disclosed by the manufacturer and regulated by the health product regulatory authorities such the FDA in the US. The UV absorbers/filters are organic chemicals that absorb UV lights within a very limited range of wavelength. Consequently, a combination of different chemicals is needed to achieve broad-spectrum protection.. Currently the FDA ...
Green Guidance The Truth in Beauty by Mindy Pennybacker, with reporting by Molly Rauch and Claire Gutierrez Not for nothing did our ancestors worship the sun, the source of Earths fertility and associated revels. What the ancients didnt understand, however, was the link between sun exposure and skin cancer. Whether you celebrate the season on a mountaintop or basking by the swimming hole, it pays to protect your skin. The key: read ingredient lists, and dont be caught napping at the expense of your or your childrens health. Sunscreens and Sunblocks. The skin is an absorptive organ, so it makes sense to use the least toxic products on it. Unfortunately, most sunscreens contain at least some iffy chemicals, including benzophenone, homosalate, and octy-methoxycinnamate, shown in animal tests to disrupt hormones and affect development of the brain and reproductive organs. PABA (para-aminobenzoic acid) has caused allergic reactions, and padimate-O and parsol 1789 (avobenzone) have the potential ...
last 10 years). Published. - Daniela R. P. Loureiro, José X. Soares, Ana Maia, André M. N. Silva, Maria Rangel, Carlos M. G. Azevedo, Steffen V. Hansen, Trond Ulven, Madalena M. M. Pinto, Salette Reis, and Carlos M. M. Afonso, One-Pot Synthesis of Xanthone by Carbonylative Suzuki Coupling Reaction, ChemistrySelect 2021, 6, 4511-4514. - Ana Alves, Paulo Costa, Madalena Pinto, Domingos Ferreira and Marta Correia‐da‐Silva, Small Molecules of Marine Origin as Potential Anti‐Glioma Agents. Molecules 2021, 26, 2707. - Madalena M. M. Pinto, Andreia Palmeira, Carla Fernandes, Diana I. S. P. Resende, Emília Sousa, Honorina Cidade, Maria Elizabeth Tiritan, Marta Correia-da-Silva and Sara Cravo, From Natural Products to New Synthetic Small Molecules: A Journey through the World of Xanthones. Molecules 2021, 26, 431.. - Phyo YZ, Teixeira J, Gonçalves R, Palmeira A, Tiritan MA, Bousbaa H, Pinto MMM, Fernandes C, Kijjoa A, Chiral derivatives of xanthones and benzophenones: Synthesis, ...
In this paper, the improvement over a novel format for selective solid-phase extraction based on a molecularly imprinted polymer (MIP) is described. A small amount of MIP has been synthesized within the superficial pores of commercial polyethylene (PE) frits and attached to its surface using benzophenone (BP), a photo-initiator capable to start the polymerization from the surface of the support material. Key properties affecting the obtainment of a proper polymeric layer, such as polymerization time and kind of cross-linker were optimized. Prepared composite material was applied to the SPE of TBZ in real samples extracts, showing an impressive clean-up ability. Calibrations showed good linearity in the concentration range of 0.05-5.00 μg g-1, referred to the original solid sample, and the regression coefficients obtained were greater than 0.998. The calculated detection limit was 0.01 μg g-1, low enough to satisfactory analysis of TBZ in real samples. Mean recoveries were about 70 % at ...
METHOD FOR PREPARING QUANTUM DOTS OF LEAD SELENIDE - Provided is a method for preparing quantum dots of lead selenide, comprising the following steps: 1) mixing selenium powder with octadecene, heating with stirring to dissolve the selenium powder fully, maintaining the temperature, then cooling to room temperature to obtain a stock solution of selenium; 2) mixing lead compound, oleic acid, octadecene and benzophenone together, and dissolving to obtain a stock solution of lead, then maintaining the temperature at 130-190° C.; 3) adding the stock solution of selenium into the stock solution of lead rapidly, and maintaining the temperature at 100-160° C., after cooling, quantum dots of lead selenide are initially prepared; 4) adding the initially prepared quantum dots of lead selenide into a mixture of toluene and methanol, centrifugating and removing the supernatant to obtain a precipitate, then redissolving the precipitate with toluene to obtain a transparent solution of quantum dots of pure ...
INDOFINE Chemical Company, Inc., established in 1981, is committed to providing high quality rare organic molecules, biochemicals and natural products for the advancement of science. We provide custom synthesis, contract research, process development and toll manufacturing in the areas of flavonoids, coumarins, acetophenones, benzophenones, chromones, fluoro-organics, heterocyclics and natural products for the pharmaceutical, agricultural and life science industries ...
Degradable polymers have gained an increased attention in the field of biomedical applications over the past decades, for example in tissue engineering. One way of improving the biocompatibility of these polymers is by chemical surface modification, however the risk of degradation during the modification procedure is a limiting factor. In some biomedical applications, for example in nerve guides, a patterned surface is desired to improve the cell attachment and proliferation.In this thesis a new non-destructive, single-step, and solvent free method for surface modification of degradable polymers is described. Poly(L-lactide) (PLLA) substrates have been functionalized with one of the following vinyl monomers; N-vinylpyrrolidone (VP), acrylamide (AAm), or maleic anhydride (MAH) grafts. The substrates were subjected to a vapor phase atmosphere constituted of a mixture of a vinyl monomer and a photoinitiator (benzophenone) in a closed chamber at very low pressure and under UV irradiation. ...
Triethanolamine (1), N-methyldiethanolamine (2) and N,N-dimethylethanolamine (3) have been used in conjunction with the 2-(2-chlorophenyl)-4,5-diphenylimidazolyl radical and triplet benzophenone to initiate the polymerisation of lauryl acrylate. The radical abstracts a hydrogen atom from the amine to generate an alpha-aminoalkyl radical. From the order of reactivity of the amines towards the lophyl (triarylimidazolyl) radical i.p. 2 ,, 1 , 3 it is concluded that hydrogen-atom abstraction occurs rather than electron followed by proton transfer. The imidazolyl radicals abstract hydrogen from thiols in a similar fashion more effectively to give thiyl radicals which initiate polymerisation of the acrylate. By following the progress of the polymerisation reactions by RTIR spectroscopy, it was concluded that the effectiveness of the amines to reduce oxygen inhibition is 1 , 3 , 2. The ability of the amines to act as synergists in the polymerisation of thin films of lauryl acrylate initiated by lophyl ...
A series of novel isomeric nickel Schiff base complexes, as well as nickel complexes of related ligands having asymmetric structures have been prepared and characterised using microanalysis, 1H and 13C NMR spectroscopy and ESI-MS. The Schiff base ligands were prepared by condensation reactions involving ethylenediamine and different derivatives of benzophenone. The solid-state structures of eight of the complexes were also determined and revealed that each possessed a regular square planar coordination geometry around the metal ion. Many of the new complexes featured at least one, and in many instances two, protonatable pendant groups that enhance aqueous solubility. This enabled the DNA binding properties of the latter complexes to be explored using a variety of instrumental approaches, including ESI-MS, circular dichroism (CD) spectroscopy, FRET melting assays and FID assays, as well as molecular docking studies. The results of experiments performed using ESI-MS suggested that none of the nickel
A photopolymerizable composition, element and method of photopolymerizing the composition or element are disclosed wherein the composition comprises an addition polymerizable compound containing ethylenic unsaturation and a co-initiator including a photopolymerization activator and a photosensitizer. In one aspect of the invention, the photosensitizer is selected to be a coumarin having an absorption maximum between about 250 and about 550 nm, and a ##STR1## substituent in the 3-position wherein R1 is alkyl or alkenyl having 1-12 carbon atoms, or a carbocyclic or heterocyclic group having 5-20 nuclear carbon and hetero atoms, the coumarin and the activator being present in an amount sufficient to provide, when the composition is coated, dried and exposed to a medium-pressure mercury light source, a speed which is at least about one-fifth that of the same composition coated, dried and exposed identically except with a co-initiator consisting of Michlers ketone and benzophenone. In another aspect of the
A photopolymerizable composition, element and method of photopolymerizing the composition or element are disclosed wherein the composition comprises an addition polymerizable compound containing ethylenic unsaturation and a co-initiator including a photopolymerization activator and a photosensitizer. In one aspect of the invention, the photosensitizer is selected to be a coumarin having an absorption maximum between about 250 and about 550 nm, and a ##STR1## substituent in the 3-position wherein R1 is alkyl or alkenyl having 1-12 carbon atoms, or a carbocyclic or heterocyclic group having 5-20 nuclear carbon and hetero atoms, the coumarin and the activator being present in an amount sufficient to provide, when the composition is coated, dried and exposed to a medium-pressure mercury light source, a speed which is at least about one-fifth that of the same composition coated, dried and exposed identically except with a co-initiator consisting of Michlers ketone and benzophenone. In another aspect of the
b) Benzil, an ® , ¯ - diketone undergoes rearrangement to benzilic acid. Fisher: Indole Synthesis: Preparation of 1.2.3.4 - tetrahydrocarbazole. This compound is prepared according to the Fisher indole synthesis starting from phenylhydrazine and cyclohexanone.. Diazotization: Forming a diazonium salt from an appropriate primary aromatic amine in the presence of HNO2.. Preparation of P - Iodonitrobenzene: By Irradiation with Sunlight OR By Reductive Coupling Prep. of Benzopinacol from benzophenone by reductive coupling. MOLECULAR REARRANGEMENT. Pinacol - Pinacolone - rearrangement. (a) Prep. of ...
michler-s-ketone definition: Noun (uncountable) 1. (organic chemistry) An organic compound, an electron-rich derivative of benzophenone, used as an intermediate in the production of dyes and pigments and as a sensitizer.Origin Named after the German chemist W...
ISOPROPYL ALCOHOL, NITROCELLULOSE, ADIPIC ACID / NEOPENTYL GLYCOL / TRIMELLITIC ANHYDRIDE COPOLYMER, TRIMETHYL PENTANYL DIISOBUTYRATE, C12‑15 ALKANE / CYCLOALKANE / AROMATIC HYDROCARBONS, HYDROGENATED TRIPHENYL PHOSPHATE, STEARALKONIUM HECTORITE, DIACETONE ALCOHOL, C6‑20 POLYOLEFIN, POLYBUTENE, HYDRATED SILICA, 1,3‑BENZENEDICARBOX‑ BENZOPHENONE‑1, CITRIC ACID, DIMETHICONE. MAY CONTAIN (±): RED 6 LAKE YLIC ACID, POLYMER WITH 1,4‑BENZENEDICARBOXYLIC ACID, 2,2‑DIMETHYL‑1,3‑ (CI 15850), RED 7 LAKE (CI 15850), IRON OXIDES (CI 77491), TITANIUM DIOXIDE PROPANEDIOL, 1,2‑ETHANEDIOL AND HEXANEDIOIC ACID/ACIDE BENZÈNE‑1,3‑ DICARBOXYLIQUE POLYMÉRISÉ AVEC LACIDE BENZÈNE‑1,4‑DICARBOXYLIQUE, LE 2,2‑DIMÉTHYLPROPANE‑1,3‑DIOL, LÉTHANE‑1.2‑DIOL ET LACIDE HEXANEDIOÏQUE ...
Eustis S, Krylova G, Smirnova N, Eremenko A, Tabor CE, Huang WY, EL-Sayed MA. Using silica films and powders modified with benzophenone to photoreduce silver nanoparticles. Journal of Photochemistry and Photobiology a-Chemistry. 2006 ;181:385-393. ...
Eustis S, Krylova G, Smirnova N, Eremenko A, Tabor CE, Huang WY, EL-Sayed MA. Using silica films and powders modified with benzophenone to photoreduce silver nanoparticles. Journal of Photochemistry and Photobiology a-Chemistry. 2006 ;181:385-393. ...
Fingerprint Dive into the research topics of (-)-(9S)-9-(3-bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3, 2-b]quinolin-8(4H)-one 1,1-dioxide (A-278637): A novel ATP-sensitive potassium channel opener efficacious in suppressing urinary bladder contractions. I. In vitro characterization. Together they form a unique fingerprint. ...
Oxybenzone was investigated by NTP (National Toxicology Program, US) for subchronic toxicity towards rats and mice by using oral and dermal exposure. Systemic effects were seen in rats and a NOAEL oral of 393 mg/kg bw/d (females) and 429 mg/kg bw/d males) respectively was derived. The NOAEL found with mice was more than a magnitude higher (7579 mg/kg bw/d females and 5981 mg/kg bw/d males) but also showed liver and kidneys being the target organ. Also the dermal route was investigated for both species and the NOAEL was set to 200 mg/kg bw/d as systemic availability by dermal route was limited and hardly any effects were seen at the high dose of 200 mg/kg bw/d and also no local effects were observed in the subchronic dermal studies. A 27 -day subacute study on rats by oral exposure resulted in a higher NOAEL but was limited in parameters observed. A NOAEL of 200 mg/kg body weight was identified in the developmental study. Given the next highest dose in the study was 1000 mg/kg body weight the use ...
One should also consider that identical to any medication, medical marijuana can work together with other prescription medications corresponding to those who cause sleepiness or thin the blood. And similar to any treatment, the unwanted effects will vary depending on the particular person taking it.. After several months, amantadines effectiveness wears off in up to half of the individuals taking it. Amantadines unwanted side effects could embrace insomnia, mottled skin, edema, agitation, or hallucinations. Researchers are not certain how amantadine works in PD, however it may enhance the effects of dopamine. COMT stands for catechol-O-methyltransferase, one other enzyme that breaks down dopamine. The medicine entacapone, opicapone, and tolcapone delay the results of levodopa by stopping the breakdown of dopamine.. We hope to compile a large knowledge base to find for what signs hashish could also be helpful , in what types of people, with what quantities and proportion of THC and CBD , how ...
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2014). Benzophenones named 2014 Contact Allergen of the Year Castanedo-Tardana, Mari Paz; Zug, Kathryn A. (2013). " ... Heurung, Ashley R.; Raju, Srihari I.; Warshaw, Erin M. (2014). "Benzophenones". Dermatitis. 25 (1): 3-10. doi:10.1097/DER. ... Benzophenones 2013 - Methylisothiazolinone - This chemical is used as a preservative in many cosmetics, lotions, and makeup ...
Sodium/benzophenone. 48 hours. 43 ppm 3 Å molecular sieves (20% by volume). 72 hours. 4 ppm ...
Alternatively, benzophenone is treated with phosphorus pentachloride: (C6H5)2CO + PCl5 → (C6H5)2CCl2 + POCl3 It undergoes ... Andrews, L. J.; W. W. Kaeding (1951). "The Formation of Benzophenone and its Diethylketal in the Ethanolysis of ... Marvel, C. S.; Sperry, W. M. (1941). "Benzophenone". Organic Syntheses.; Collective Volume, 1, p. 95 Spaggiari, Alberto; ... hydrolysis to benzophenone. (C6H5)2CCl2 + H2O → (C6H5)2CO + 2 HCl It is used in the synthesis of tetraphenylethylene, ...
Cadmium; some of the noble gases, for example xenon; zinc; benzophenone; and a large number of organic dyes, are also used as ...
Stephen aldehyde synthesis Marvel, C. S.; Sperry, W. M. (1928). "Benzophenone". Organic Syntheses. 8: 26. doi:10.15227/orgsyn. ...
Acetone and benzophenone (C6H5C(O)C6H5) are symmetrical ketones. Acetophenone (C6H5C(O)CH3) is an unsymmetrical ketone. Many ... "Benzophenone". Organic Syntheses. 8: 26. doi:10.15227/orgsyn.008.0026. Furniss, Brian; Hannaford, Antony; Smith, Peter; ... for example acetone and benzophenone. These nonsystematic names are considered retained IUPAC names, although some introductory ...
Clusia resin contains polyprenylated benzophenones. In some areas of Chile and Argentina Andean valleys, propolis contains ...
... benzophenone (vismiaphenone-C); and a new benzophenone, 2,2-dimethyl-8-benzoyl-3,7-dihydroxy-5-methoxy-6-(3-methyl-2-butenyl)-3 ... Four benzophenones have been isolated from Garcinia pseudoguttifera: 6-hydroxy-2,4-dimethoxy-3,5-bis(3-methyl-2-butenyl) ... Ali, Sadaquat; Goundar, Renee; Sotheeswaran, Subramaniam; Beaulieu, Christian; Spino, Claude (1 January 2000). "Benzophenones ... benzophenone (myrtiaphenone-A); 2,2-dimethyl-8-benzoyl-7-hydroxy-5-methoxy-6-(3-methyl-2-butenyl)benzopyran (myrtiaphenone-B); ...
see Benzophenone). Oxybenzone, titanium oxide and octyl methoxycinnamate are photoprotective agents used in many sunscreens, ...
Benzophenone-8 3% USA, AUS X X Oxybenzone Benzophenone-3, Eusolex 4360, Escalol 567 6% (US) 10% (AUS, EU) 5% (JP) EU, USA, AUS ... Benzophenone-9 Uvinul DS 49, CAS 3121-60-6, Sodium Dihydroxy Dimethoxy Disulfobenzophenone [67] 10% JP ... Currently, benzophenone-4 and ethylhexyl methoxycinnamate are the two sunscreens most commonly used in hair products. The ... 2-Hydroxy-4-Methoxybenzophenone-5-sulfonic acid, 3-Benzoyl-4-hydroxy-6-methoxybenzenesulfonic acid, Benzophenone-4, Escalol 577 ...
... s Benzophenone hydrazone, an illustrative hydrazone Carbonyl cyanide m-chlorophenyl hydrazone Gyromitrin (Acetaldehyde ... an antihypertensive drug X-ray structure of DNP-derived hydrazone of benzophenone. Selected parameters: C=N, 128 pm; N-N, 1.38 ... "Benzophenone 2,4-dinitrophenylhydrazone". Acta Crystallographica Section E. 62 (12): o5686-o5688. doi:10.1107/S1600536806048112 ...
A typical stabilizer is benzophenone-1.. Types[edit]. Base coat[edit]. This type of nail polish is a clear, milky-colored, or ...
Benzophenone is proposed as an intermediate. 2NaPh + PhCOCl → Ph3CONa + NaCl Metallation reactions with phenylsodium proceed in ...
... (benzophenone-8) is an organic compound used in sunscreen to block UVB and short-wave UVA (ultraviolet) rays. It ... is a derivative of benzophenone. It is a yellow powder with a melting point of 68 °C. It is insoluble in water, but moderately ...
A typical stabilizer is benzophenone-1. This type of nail polish is a clear, milky-colored, or opaque pink polish formula that ...
Benzophenones, which form reactive triplet carbonyl species upon irradiation, often require long periods of irradiation which ... Prestwich, Glenn D.; Dormán, György; Elliott, John T.; Marecak, Dale M.; Chaudhary, Anu (1997-02-01). "Benzophenone Photoprobes ...
It photooxidizes in air to benzophenone and sulfur. Since its discovery, a variety of related thiones have been prepared. ...
Benzophenone Cyclopropenone Singh G, Lavanya M (January 2010). "Topical immunotherapy in alopecia areata". International ...
Acetone and benzophenone (C6H5C(O)C6H5) are symmetrical ketones. Acetophenone (C6H5C(O)CH3) is an asymmetrical ketone. In the ... Marvel, C. S.; Sperry, W. M. (1928). "Benzophenone". Organic Syntheses. 8: 26. doi:10.15227/orgsyn.008.0026.. ... In this prototypical example involving benzophenone, the tetrahedral intermediate expels phenyl anion to give benzamide and ... for example acetone and benzophenone. These nonsystematic names are considered retained IUPAC names,[4] although some ...
D.E. Pearson; R.W. Brockman (1952). "The Effect of substituents on the Polargraphic Half-Wave Potentials of Benzophenones". ...
Ketones such as benzophenones, and 1,1-disubstituted olefins are typical substrates. Hydrides of tungsten, chromium, osmium, ...
Specifically, balanol's distal benzophenone ring is able to rotate. In fact, in complex with PKA, balanol's distal benzophenone ... The benzophenone and hexahydroazepane moieties are connected via an ester linkage, and the azepane and benzoyl moieties are ... For instance, balanol's benzophenone rings are positioned beside the glycine-rich loop and further from the more polar ... For instance, balanol's benzophenone ring interacts with numerous highly conserved residues in PKA such as Gly52, Phe54, Asp184 ...
They fall into several structural classes: Benzophenones Benzophenone-3 (BP3) Benzophenone-4 (BP4) Salicylates Homosalate (HMS ... Benzophenones (BPs) are widely used in UV filters, fragrance enhancers, and plastic additives. The major sources of BP-3 are ... In the presence of other UV filters, Benzotriazole, and humic acids, Benzophenone -3 degradation was observed through the loss ... Liu, YS (2011). "Photostability of the UV filter benzophenone-3 and its effect on the photodegradation of benzotriazole in ...
... can convert to benzophenone through a retro-aldol condensation. The reaction occurs slowly over time, yielding ... Downs, C. A.; DiNardo, Joseph C.; Stien, Didier; Rodrigues, Alice M. S.; Lebaron, Philippe (7 March 2021). "Benzophenone ... significant concentration of benzophenone in all commercial cosmetics tested formulated with octocrylene. In coral, octocrylene ...
Pirrung, M. C.; Roy, B. G.; Gadamsetty, S. (April 2010). "Structure-Reactivity Relationships in (2-Hydroxyethyl)benzophenone ...
A similar process based on benzophenone has also been described. The final stage involves hydrolysis of the purified ketazine: ...
Benzophenone. Dobavljeno iz "https://sh.wikipedia.org/w/index.php?title=Benzofenon&oldid=33626666" ...
Typical UV-absorbers are hydroxy-substituted benzophenones, related to the chemicals used in sunscreen. Plastic bag Polymer ...
"Solid-phase microextraction and GC-ECD of benzophenones for detection of benzodiazepines in urine". Journal of Analytical ...
The characteristics shown by chemical analyses suggest the presence of benzophenones as active compounds. Therefore, ...
... has role plant metabolite (CHEBI:76924) benzophenone (CHEBI:41308) is a benzophenones (CHEBI:22726) ... CHEBI:41308 - benzophenone. Main. ChEBI Ontology. Automatic Xrefs. Reactions. Pathways. Models. .gridLayoutCellStructure { min- ... Benzophenone is widely used as a building block in organic synthesis, and as a photosensitizer and photo-initiator in UV-curing ... mesotrione (CHEBI:38321) has functional parent benzophenone (CHEBI:41308). Ro 48-8071 (CHEBI:101064) has functional parent ...
Benzophenone is a widely used building block in organic chemistry, being the parent diarylketone. Benzophenone can be used as a ... Benzophenone is used as an additive in flavorings or perfumes for "sweet-woody-geranium-like notes." Benzophenone is produced ... In 2014, benzophenones were named Contact Allergen of the Year by the American Contact Dermatitis Society. Benzophenone is an ... Substituted benzophenones such as oxybenzone and dioxybenzone are used in many sunscreens. The use of benzophenone-derivatives ...
Benzophenone-10 (mexenone, 2-hydroxy-4-methoxy-4-methyl-benzophenone) Benzophenone-11 (benzophenone-2 and benzophenone-6) ... Benzophenone-3 (oxybenzone) Benzophenone-4 (sulisobenzone) Benzophenone-5 (sulisobenzone sodium) Benzophenone-6 (2,2-dihydroxy ... Benzophenone-12 (octabenzone, used to protect plastics) Chemicalland21: Benzophenone Inhaltsstoffe Kosmetik: Benzophenone-11 ( ... 4-dimethoxybenzophenone) Benzophenone-7 (5-chloro-2-hydroxybenzophenone) Benzophenone-8 (dioxybenzone) Benzophenone-9 (sodium ...
Benzophenone-3 (BP-3) is a naturally occurring chemical found in some flowering plants. BP-3 absorbs and scatters the suns ...
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
Other names: 4-(t-Butyl)benzophenone; Methanone, [4-(1,1-dimethylethyl)phenyl]phenyl- ...
Toxicity Studies of Benzophenone Administered in Feed to F344/N Rats and B6C3F1 Mice (CASRN 119-61-9) ... Toxicology and Carcinogenesis Studies of Benzophenone (CASRN 119-61-9) in F344/N Rats and B6C3F1 Mice (Feed Studies) ... Citation: FINAL STUDY REPORT DEVELOPMENTAL TOXICITY EVALUATION FOR BENZOPHENONE (CASRN 119-61-9) ADMINISTERED BY GAVAGE TO NEW ... Citation: Final Study Report Developmental Toxicity Evaluation for Benzophenone (CASRN 119-61-9) Administered by Gavage to New ...
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... benzophenone 0.95; CAS No.: 256926-87-1; Synonyms: [2-(Dicyclohexylphosphino)phenyl]phenylmethanone; Linear Formula: C25H31OP; ...
... benzophenone 96%; CAS Number: 32752-54-8; EC Number: 251-197-7; Linear Formula: C14H11BrO; find Sigma-Aldrich-449385 MSDS, ...
Benzophenone was administered in the diet to rats at target dose levels of 20 mg/kg bw/d for 90 days and 100 or 500 mg/kg bw/d ... Benzophenone was administered in the diet to rats at target dose levels of 20 mg/kg bw for 90 days and 100 or 500 mg/kg bw for ... The concentration of benzophenone in the low-, mid- and high-dose diets was evaluated at week 1 of the study and the ... Stability and homogeneity of benzophenone were determined in samples of the diets for the low- and high-dose groups obtained ...
Benzophenone does not contain any functional groups that are susceptible to dissociation.. Possibility of hazardous reactions: ...
Benzophenone had no adverse ef-fect on prenatal viability or the overall inci-dences of fetal malformations or variations. The ... In this study, benzophenone (100, 200, or 300 mg/kg/day) or its vehicle (0.5% methylcellulose) was administered to female CD ... Benzophenone occurs naturally in some fruits and is used commercially as a perfumery and flavoring ingredient. This study was ... Rebound increases in feed intake were noted at all doses of benzophenone from gd 15 to 18, and 18 to 19. The high dose showed a ...
4,4-bis(dimethylamino)benzophenone. ↓Other names: Regulatory process names [4] Other names [1] IUPAC names [6] ...
... L. F. Vieira Ferreira,1 A. I. Costa ... phenylpropiophenone and benzophenone inclusion complexes with calix[4], [6] and [8]arenes," Physical Chemistry Chemical Physics ... and zeolite surfaces on the excited triplet state of benzophenone, B. T. ; a spectroscopic and kinetic study," Photochemical & ... L. F. Vieira Ferreira, I. Ferreira Machado, J. P. Da Silva, and T. J. F. Branco, "Surface photochemistry: benzophenone as a ...
Precautionary Statements: P280i-P264-P305+P351+P338-P310a-P301+P312a-P501a Wear eye/face protection. Wash thoroughly after handling. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Dispose of contents/container in accordance with local/regional/national/international regulations. ...
Benzophenone-1, Benzophenone-3, Benzophenone-4, Benzophenone-5, Benzophenone-9 and Benzophenone-11 protect cosmetics and ... Benzophenone-1 and Benzophenone-3 are used mostly in the formulation of nail polishes and enamels. These Benzophenone ... The Food and Drug Administration (FDA) has approved the use of Benzophenone-3 and Benzophenone-4 as safe and effective, over- ... Benzophenone-3 was nonsensitizing and nonphototoxic. Benzophenones were nonmutagenic when tested both with and without ...
michlers ketone, 4,4-bis dimethylamino benzophenone, michler ketone, bis 4-dimethylamino phenyl methanone, bis 4- ... michlers ketone, 4,4-bis dimethylamino benzophenone, michler ketone, bis 4-dimethylamino phenyl methanone, bis 4- ... michlers ketone, 4,4-bis dimethylamino benzophenone, michler ketone, bis 4-dimethylamino phenyl methanone, bis 4- ...
Products formulated with benzophenone-3 must read contains oxybenzone on their product labels due to allergies. Colipa ... In 2006, the SCCP stated that a dermal absorption study of benzophenone-3 in concentrations up to 10% was needed to calculate ... The European Commission (EC) is requesting opinions from its Scientific Committee on Consumer Products (SCCP) on benzophenone-3 ... recently applied for a maximum allowed concentration of benzophenone-3; therefore, the SCCP must determine whether the ...
Benzophenone is widely employed as a photo initiator in UV-curing applications such as inks, imaging and clear coatings in the ... For a review of the use of benzophenone as a triplet-sensitizer in photochemistry, see: Synthesis, 249 (1981). ... Cork as extractor phase for determination of benzophenone, triclocarban and parabens in aqueous samples. Anal. Chim. Acta 2015, ... Optimization of dispersive micro solid-phase extraction for the rapid determination of benzophenone-type ultraviolet absorbers ...
Benzophenone-4-iodoacetamide , C15H12INO2 , CID 131289 - structure, chemical names, physical and chemical properties, ...
Allergy to benzophenones (oxybenzone, sulizobenzone, dioxybenzone, mexenone). Authoritative facts about the skin from DermNet ... Am I allergic to benzophenone?. Benzophenone allergy is diagnosed by performing patch tests with 5% benzophenone in petrolatum. ... Treatment of benzophenone allergy. Those diagnosed with benzophenone allergy should avoid exposure to benzophenone containing ... Benzophenone 3 (2-hydroxy-4-methoxyphenyl: oxybenzone). *Benzophenone 4 (2-hydroxy-4-methoxy benzophenone-5-sulfonic acid: ...
Benzophenone) Chemical Abstracts Service Registry Number 119-61-9 Environment and Climate Change Canada Health Canada June 2018 ... it is rather benzophenone derivatives (i.e., benzophenone -1, benzophenone -2, or benzophenone -3) that are present in these ... benzophenone is used in the synthesis of benzophenone derivatives. In the United States, benzophenone is permitted for use in ... Various known or novel benzophenone derivatives, generally designated as benzophenone-1 through benzophenone-12, as well as ...
This page contains information on the chemical Benzophenone, 2-(3-(diethylamino)propoxy)-, hydrogen phosphate including: 3 ... 2-(3-(Diethylamino) propoxy) benzophenone hydrogen phosphate*Benzophenone, 2-(3-(diethylamino) propoxy)-, hydrogen phosphate ... Benzophenone, 2-(3-(diethylamino) propoxy)-, hydrogen phosphate. Identifications. *CAS Number: 10429-26-2*Synonyms/Related:* ... Chemical Database - Benzophenone, 2-(3-(diethylamino)propoxy)-, hydrogen phosphate. EnvironmentalChemistry.com. 1995 - 2018. ...
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... method for the determination of 14 benzophenones (BPs) in a food simulant used in migration studies of food packaging materials ...
Reduction of Benzophenone with Sodium Borohydride. Safety precaution: Sodium Borohydride Toxic & Irritant Wash spillages away ... Benzophenone Harmful & Irritant Wash spillages away with water Hydrochloric acid Corrosive & Irritant wash spillages away with ... To this the mixture of sodium borohydride and benzophenone was poured slowly into the beaker. The precipitate was collected ... Introduction In this experiment, we will see the reduction of the aromatic ketone benzophenone with sodium borohydride to ...
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  • Substituted benzophenones such as oxybenzone and dioxybenzone are used in some sunscreens. (ebi.ac.uk)
  • As part of sunscreen products, which are OTC drugs in the United States, Benzophenone-3 (Oxybenzone) and Benzophenone-4 (Sulisobenzone) protect the skin from the harmful effects of the sun. (cosmeticsinfo.org)
  • Products formulated with benzophenone-3 must read 'contains oxybenzone' on their product labels due to allergies. (skininc.com)
  • Benzophenones, including oxybenzone, combined with other sunscreen agents still provide excellent sun protection. (dermnetnz.org)
  • Bluthgen N, Zucchi S, Fent K (2012) Effects of the UV filter benzophenone-3 (oxybenzone) at low concentrations in zebrafish (Danio rerio). (springer.com)
  • Kannan says benzophenone-3, which appears on sunscreen labels as oxybenzone, is even more strongly estrogenic than bisphenol-A (BPA), a chemical found in certain plastics that's recently been the subject of regulatory scrutiny. (webmd.com)
  • Benzophenone-1 is a chemical additive that's mostly used in nail polishes, according to the cosmetics industry web site CosmeticsInfo.org, but it also forms when the body breaks down oxybenzone, the major ingredient in sunscreen. (webmd.com)
  • Substituted benzophenones such as oxybenzone and dioxybenzone are used in sunscreen. (shreejiexports.net)
  • Oxybenzone (2-hydroxy-4-methoxyphenone, benzophenone-3) is one of the UV filters commonly found in sunscreens. (univ-amu.fr)
  • Pursuant to section 74 of the Canadian Environmental Protection Act, 1999 (CEPA), the Minister of Environment and the Minister of Health have conducted a screening assessment of methanone, diphenyl-, herein referred to as benzophenone. (canada.ca)
  • Pursuant to section 74 of the Canadian Environmental Protection Act, 1999 (CEPA) (Canada 1999), the Minister of the Environment and the Minister of Health have conducted a screening assessment of methanone, diphenyl-, herein referred to as benzophenone (BP), to determine whether this substance presents or may present a risk to the environment or to human health. (canada.ca)
  • Benzophenone, an aromatic ketones (diphenyl ketone), is an important compound in organic photochemistry and perfumery as well as in organic synthesis. (chemicalland21.com)
  • The simplest member of the class of benzophenones, being formaldehyde in which both hydrogens are replaced by phenyl groups. (ebi.ac.uk)
  • Toxicological effects of the sunscreen UV filter, benzophenone-2, on planulae and in vitro cells of the coral, Stylophora pistillata. (semanticscholar.org)
  • The use of benzophenone-derivatives which structurally resemble a strong photosensitizer has been criticized (see sunscreen controversy). (wikipedia.org)
  • The high-strength polymer PEEK is prepared from derivatives of benzophenone. (wikipedia.org)
  • Benzophenone derivatives are known to be pharmacologically active. (wikipedia.org)
  • The four main benzophenone derivatives that have been used widely in sunscreens and cosmetics are listed below. (dermnetnz.org)
  • In benzophenone allergic individuals, products containing benzophenone or benzophenone derivatives may cause redness, swelling, itching and fluid-filled blisters. (dermnetnz.org)
  • Read product labels and avoid products that contain benzophenone or any of its derivatives. (dermnetnz.org)
  • In toluene under reflux complexes 3, 4, 7, and 8 react with benzophenone imine and 2-vinylpyridine to afford the metalated derivatives (M = Ru (11), Os (12)) and (M = Ru (13), Os (14)), releasing benzene and styrene. (csic.es)
  • HPLC allowed their quantification in all resins, revealing a distribution of benzophenone derivatives distinct from each other. (uchile.cl)
  • 5 . A photosensitive composition according to claim 1 comprising in addition to the components (A), (B) and (C) at least one photosensitizer compound (E) selected from the group consisting of benzophenone and its derivatives, thioxanthone and its derivatives, anthraquinone and its derivatives, and coumarin and its derivatives. (google.com)
  • Bis(trifluoromethyl) benzophenone Bis[4-(trifluoromethyl)phenyl]methanone CAS 21084-22-0 EINECS Product description: 3,4'-Bis(trifluoromethyl) benzophenone ,White to light yellow crystalline powder, pharmaceutical intermediates and materials intermediates. (peerflix.com)
  • Urinary concentrations of benzophenone-type UV filters in U.S. women and their association with endometriosis. (semanticscholar.org)
  • These Benzophenone ingredients are also used in bath products, makeup products, hair products, sunscreens and skin care products. (cosmeticsinfo.org)
  • Often benzophenone is used in combination with other chemical absorbing sunscreens to augment and stabilise the final product. (dermnetnz.org)
  • People may be exposed through dermal application of sunscreens and cosmetic products.Small amounts of benzophenone-3 can be absorbed through human skin and excreted in the urine, mostly as a glucuronidated conjugate (Gonzalez et al. (cdc.gov)
  • Gustavsson Gonzalez H, Farbrot A, Larko O.Percutaneous absorption of benzophenone-3, a common component of topical sunscreens. (cdc.gov)
  • First used as a preserver to extend the shelf life of paints, varnishes, and other industrial products, benzophenones were added to sunscreens in the 1950s. (thefreedictionary.com)
  • Benzophenone-3 is often used in sunscreens as well as in synthetic resins and polymers. (foodpackagingforum.org)
  • Urinary concentrations of two benzophenone-type ultraviolet filters (BP-2, BP-8), chemicals used as sunscreens, were found to be associated with select semen endpoints. (fertstertforum.com)
  • Benzophenone is a common photosensitizer in photochemistry. (wikipedia.org)
  • Introduction In this experiment, we will see the reduction of the aromatic ketone benzophenone with sodium borohydride to diphenylmethanol. (antiessays.com)
  • Benzophenone is an aromatic ketone, generally used in cosmetic products as ultraviolet (UV) absorber however it is suspected of causing cancer and toxic to aquatic life with long-term effects [ 1 ]. (analchem.net)
  • Benzophenone occurs naturally in some fruits and is used commercially as a perfumery and flavoring ingredient. (nih.gov)
  • It is also used as a UV stabilizer in plastic surface coatings and polymers.Benzophenone-3 is a common ingredient in sun-blocking agents. (cdc.gov)
  • Benzophenone is used as flavor ingredient, a fragrance enhancer, a perfume fixative, and an additive for plastics coating and adhesive formulations. (analchem.net)
  • Benzophenone is widely used as a building block in organic synthesis, and as a photosensitizer and photo-initiator in UV-curing applications such as inks, imaging, and clear coatings in the printing industry. (ebi.ac.uk)
  • Computational Study of the Radical Mediated Mechanism of the Formation of C8, C5, and C4 Guanine:Lysine Adducts in the Presence of the Benzophenone Photosensitizer. (semanticscholar.org)
  • IARC determined that there is sufficient evidence in laboratory animals for the carcinogenicity of benzophenone. (canada.ca)
  • 1994).IARC and NTP have no ratings as to human carcinogenicity of benzophenone-3. (cdc.gov)
  • Besides its high usability as industrial chemical, it contributes to carcinogenicity due to the high reactivity and instability of benzophenone anion (benzophenone work via formation of an anion). (analchem.net)
  • In 2014, benzophenones were named Contact Allergen of the Year by the American Contact Dermatitis Society. (wikipedia.org)
  • Because they commonly cause contact allergic dermatitis , benzophenones were declared the Contact Allergen of the Year for 2014 by the American Contact Dermatitis Society (ACDS). (dermnetnz.org)
  • benzophenone hydrazone is used in the antibiotics synthesis of 6-APA and 7-ACA of the carboxyl protecting groups and other organic compounds. (ydachem.com)
  • Benzophenone is not a precursor for the synthesis of another compound of olfactory interest. (scentree.co)
  • Benzophenone-N-ethyl piperidine ether analogues--synthesis and efficacy as anti-inflammatory agent. (sparrho.com)
  • Carasek, E. A novel approach to bar adsorptive microextraction: Cork as extractor phase for determination of benzophenone, triclocarban and parabens in aqueous samples. (alfa.com)
  • Exposure to environmental phenols (e.g., bisphenol A, benzophenone-3, and triclosan) and parabens is widespread in the population. (nih.gov)
  • We examined the association of bisphenol A (BPA), benzophenone-3 (BP-3), triclosan (TCS), and parabens with serum total testosterone (TT) levels in child and adolescent participants (ages 6-19 years) in the National Health and Nutrition Examination Survey (NHANES) 2011-2012. (nih.gov)
  • They found that four sunscreen chemicals--parabens, cinnamates, benzophenones and a camphor derivative--cause the viruses to replicate until their algae hosts explode, spilling virus particles into the surrounding seawater, where they can infect neighbouring coral communities. (thefreedictionary.com)
  • We have developed a sensitive method for measuring BPA, 4-tert-octylphenol (tOP), benzophenone-3 (BP-3), one chlorophenols triclosan, and four parabens. (cdc.gov)
  • Benzophenone ingredients absorb and dissipate UV radiation, which serves to protect cosmetics and personal care products. (cosmeticsinfo.org)
  • Background The capability of benzophenone-3 (BP-3) to absorb and dissipate ultraviolet radiation facilitates its use as a sunscreen agent. (cdc.gov)
  • The study, which is published in Environmental Science & Technology , measured concentrations of five kinds of chemicals called benzophenones in the urine of more than 600 women who were evaluated for endometriosis . (webmd.com)
  • Its relationship with Viachem, a supplier of specialty and fine chemicals, enables the company to increase market share for its MAXGARD brand of substituted benzophenones , according to Jimmy Wooten, global product manager for Syrgis Performance Specialties. (thefreedictionary.com)
  • To assess benzophenone-type ultraviolet (UV) filter concentrations, chemicals used in sunscreen and personal care products, and semen endpoints. (fertstertforum.com)
  • Through the structure-activity relationship, we found that an increase in the number of methyl, chloro and fluoro groups in a benzophenone ring on compound 9d resulted in higher potency compared to other compounds. (rsc.org)
  • Series of compounds having benzophenone moiety were designed. (ebscohost.com)
  • This study describes a procedure for determining eight benzophenone-derived compounds in surface waters and sediments. (nih.gov)
  • Benzophenone is the organic compound with the formula (C6H5)2CO, generally abbreviated Ph2CO. (wikipedia.org)
  • Benzophenone -3 Molecular Formula:C14H12O3 Package: 25kg/drum 2. (peerflix.com)
  • Benzophenone is a widely used building block in organic chemistry, being the parent diarylketone. (wikipedia.org)
  • The ecological risk of benzophenone was characterized using the ecological risk classification of organic substances (ERC). (canada.ca)
  • Benzophenones can act as optical filters or deactivate substrate molecules that have been excited by light for the protection polymers and organic substances. (chemicalland21.com)
  • Benzophenone Hydrazone is the organic compound, widely used building block in organic chemistry. (shreejiexports.net)
  • Contact Now Supply Pharma Intermediate of benzophenone Benzophenone is ultraviolet absorbent, organic pigment, medicine, spices, pesticide intermediates. (mwprochem.com)
  • In carrageenan-induced foot pad edema assay, benzophenone analogues showed an interesting anti-inflammatory activity. (sparrho.com)
  • Synthetic access to these is possible using the Ni-[(Benzylprolyl)amino]benzophenone (BPB) complex as a chiral auxiliary. (strath.ac.uk)
  • Prominent & Leading Wholesale Trader from Delhi, we offer benzophenone 3, amino silicon emulsion cs 618, polyquaternium 10, methyl paraben, myristic acid and cctg powder. (continentalchemicals.in)
  • Interactions of benzophenone (BP) with the Torpedo nicotinic acetylcholine receptor (nAChR) were characterized by electrophysiological analyses, radioligand binding assays, and photolabeling of nAChR-rich membranes with [3H]BP to identify the amino acids contributing to its binding sites. (edu.au)
  • N -(Alkoxycarbonyl)-( S )-α-amino acid methyl esters gave optically active diphenylmethyl ketones by reduction with benzophenone. (figshare.com)
  • Antibacterial and Antioxidant Xanthones and Benzophenone from Garcinia smeathmannii", Planta Medica , vol. 81, 2015, pp. 594-599. (uni-bielefeld.de)
  • Benzophenone prevents ultraviolet (UV) light from damaging scents and colors in products such as perfumes and soaps. (wikipedia.org)
  • In cosmetics and personal care products, Benzophenone-1 and Benzophenone-3 are used mostly in the formulation of nail polishes and enamels. (cosmeticsinfo.org)
  • Benzophenone-1, Benzophenone-3, Benzophenone-4, Benzophenone-5, Benzophenone-9 and Benzophenone-11 protect cosmetics and personal care products from deterioration by absorbing, reflecting, or scattering UV rays. (cosmeticsinfo.org)
  • The CIR Expert Panel evaluated the scientific data and concluded that Benzophenone-1, -3, -4, -5, -9 and -11 were safe for use in cosmetics and personal care products. (cosmeticsinfo.org)
  • The European Commission (EC) is requesting opinions from its Scientific Committee on Consumer Products (SCCP) on benzophenone-3 and toluene. (skininc.com)
  • The first contact reaction to benzophenones in sunscreen products was first documented in 1972. (dermnetnz.org)
  • Those diagnosed with benzophenone allergy should avoid exposure to benzophenone containing products. (dermnetnz.org)
  • A comparison of estimated levels of exposure to benzophenone associated with the use of certain products (i.e., nail polish and interior paint) and critical effect levels results in margins of exposure that are potentially inadequate to account for uncertainties in the health effects and exposure databases. (canada.ca)
  • These include the pharmaceutical ketoprofen, its phototransformation products 3-ethylbenzophenone and 3-acetylbenzophenone, and five benzophenone-type ultraviolet (UV) filters. (nih.gov)
  • Benzophenones are used in a variety of products because they protect against UV light. (webmd.com)
  • Phenols are also used as sunscreen agents for skin protection, and as UV filters in cosmetic products and plastics to improve stability (e.g., benzophenone-3 [BP-3]), or used as bactericides (e.g., triclosan) in soap and other personal care products. (cdc.gov)
  • When benzophenone reduces to diphenylmethanol, leftover products include the CH2OH and NaBH3 species. (sciencing.com)
  • We doesn't provide benzophenone 4 uses products or service, please contact them directly and verify their companies info carefully. (peerflix.com)
  • A chemical linked to cancer, benzophenone is used in cosmetics such as lip balm and nail polish to protect the products from UV light. (safecosmetics.org)
  • The reductive coupling of aliphatic esters with benzophenones by Zn-TiCl 4 in THF gave two- and four-electron reduced products, diaryl-(hydroxy)-methyl ketones, and diarylmethyl ketones selectively by controlling the reaction conditions. (figshare.com)
  • In the reaction of aromatic esters with benzophenones, diarylmethyl ketones were obtained as the sole products. (figshare.com)
  • The use of benzophenone allows manufacturers to package the products in clear glass or plastic without which, opaque or dark packaging would be required [ 6 ]. (analchem.net)
  • Dose selection was based on a screening study in which Sprague-Dawley-derived (CD) rats were treated by gavage with benzophenone (0, 25, 50, 100, 200, or 300 mg/kg body weight/day) on gestational days 6 through 19 (NTP, 1998b). (nih.gov)
  • In this study, benzophenone (100, 200, or 300 mg/kg/day) or its vehicle (0.5% methylcellulose) was administered to female CD rats by gavage on gd 6 through 19. (nih.gov)
  • Chronic exposure to benzophenone via the oral route caused cancer in rats and mice. (canada.ca)
  • The ultraviolet filter benzophenone 2 interferes with the thyroid hormone axis in rats and is a potent in vitro inhibitor of human recombinant thyroid peroxidase. (thefreedictionary.com)
  • It was found that exposure to benzophenone-3 in rats led to an increase of non-neoplastic lesions of the testis and pancreas in males and of the uterus and adrenal cortex in females. (foodpackagingforum.org)
  • Reduction Of Benzophenone With Sodium Borohydride. (antiessays.com)
  • To this the mixture of sodium borohydride and benzophenone was poured slowly into the beaker. (antiessays.com)
  • This is determined to be 1.90 × 107 s-1 for benzophenone (BP) and 1.83 × 107 s-1 for decafluorobenzophenone in sodium dodecyl sulfate (SDS) micelles, indicating that this value is not limited by the rate of spin mixing, and thus that the kinetic approach used is justified. (le.ac.uk)
  • Benzophenone reacts with sodium borohydride in a methanol solution. (sciencing.com)
  • In 2006, the SCCP stated that a dermal absorption study of benzophenone-3 in concentrations up to 10% was needed to calculate the ingredient's margin of safety under proposed conditions of use. (skininc.com)
  • More facts of improper selection of gonzalez h, farbrot a, larko o, wennberg am: percutaneous absorption of the sunscreen benzophenone-3 after repeated whole-body applications, with and without ultraviolet irradiation. (casinoreviewsnow.com)
  • According to gonzalez h, farbrot a, larko o, wennberg am: percutaneous absorption of the sunscreen benzophenone - 3 after several repeated whole - body applications, with and without ultraviolet irradiation. (casinoreviewsnow.com)
  • Benzophenone -3 segment UVB UVA absorption sunscreen as assist in the absorber, the addition of UV protection and enchanced SPF activity, oil soluble powder, safe use . (peerflix.com)
  • Benzophenone is a compound of the scent principle of grapes, black tea and papaya among others. (scentree.co)
  • Ding, W. H. Optimization of dispersive micro solid-phase extraction for the rapid determination of benzophenone-type ultraviolet absorbers in aqueous samples. (alfa.com)
  • Urinary benzophenone-3 levels include both conjugated and unconjugated forms and reflect recent exposure to the chemical. (cdc.gov)
  • Another, less well-known reaction to produce benzophenone is the pyrolysis of anhydrous calcium benzoate. (wikipedia.org)
  • The hydrogen abstraction reaction of benzophenones in micellar interiors was studied by the effect of a short, resonant microwave pulse on the recombination kinetics under magnetic fields of approximately 0.3 T. This technique allows all the significant rate constants in the reaction to be determined, in particular the singlet state recombination rate constant, which is very difficult to accurately determine by other techniques. (le.ac.uk)
  • Benzhydrylamines can be synthesized from benzophenones by the Leuckart reaction via the intermediate benzhydrylformamides. (thefreedictionary.com)
  • Focusing on one benzophenone molecule at a time is helpful for explaining and understanding reaction steps. (sciencing.com)
  • Benzophenone can be synthesized by a Friedel-Craft reaction from benzene by reaction with benzoyl chloride in the catalytic presence of aluminum chloride (Lewis acid). (scentree.co)
  • These results suggested that biofield treatment has significantly altered the thermal, spectroscopic, and chemical properties of benzophenone, which could make them more useful as reaction intermediate in industrial applications. (analchem.net)
  • The Benzophenones are a group of aromatic ketones, all of which contain the diphenylketone structural element. (cosmeticsinfo.org)
  • The benzophenones are a group of aromatic ketones that have both pharmaceutical and industrial applications. (dermnetnz.org)
  • Novel benzophenone analogs ( 9a-d and 10a-d ) substituted with methyl, chloro and fluoro groups at different positions on an identical chemical backbone and incorporating variations in the number of substituents have been synthesized in a multistep process and characterized. (rsc.org)
  • Benzphenone-1 - benzophenone-12 (BP-1 -BP-12) are UVA/UVB absorbers. (wikipedia.org)
  • Benzophenone is widely employed as a photo initiator in UV-curing applications such as inks, imaging and clear coatings in the printing industry. (alfa.com)
  • Sun filter materials powder Benzophenone -3 prevent from UVB, UVA 1. (isp.org.cn)
  • Benzophenone occurs naturally in the environment and is synthetically manufactured. (canada.ca)
  • Benzophenone-3 (2-hydroxy-4-methoxybenzophenone) occurs naturally in some flowering plants. (cdc.gov)
  • The NHANES 2003-2004 levels of urinary benzophenone-3 have been described by Calafat et al. (cdc.gov)
  • Higher urinary benzophenone-3 levels also are apparent in non-Hispanic whites and females in NHANES 2005-2010 (CDC, 2012). (cdc.gov)
  • In a study of 90 U.S. females aged 6-8 years, the median urinary benzophenone-3 level of 14.7 µg/L was comparable to the median levels of children 6-11 years of age (15.8-18.7 µg/L) in the NHANES 2003-2010 subsamples (Calafat et al. (cdc.gov)
  • 2007).Total benzophenone-3 urinary concentrations were detectable in 90% of a small sample of adults in whom the values ranged up to 3000 µg/L (Ye et al. (cdc.gov)
  • 2005). Following short-term application of 10% benzophenone-3 lotion, men and women had mean urinary levels of 140 and 60 µg/L, respectively (Janjua et al. (cdc.gov)
  • The reduction starts with breaking the benzophenone carbon-oxygen double bond. (sciencing.com)
  • This complex is the main second product of benzophenone reduction. (sciencing.com)
  • Central carbon of benzophenone bonds with one hydrogen from borohydride (BH4), while the benzophenone oxygen briefly exists as an anion, which is a negatively charged atom. (sciencing.com)
  • Since four benzophenone molecules each attract a hydrogen atom from the "BH4" hydrogen donor, four "CH2OH"s bond with each boron (B) atom. (sciencing.com)
  • Holding a highly reputed and trusted market standing, we are engaged in offering Benzophenone Hydrazone . (shreejiexports.net)
  • Benzophenone 4 is a photo stabilizer and sunscreen agent used for its ability to absorb UV rays. (skin-hairactives.com)
  • The concentration of benzophenone in the low-, mid- and high-dose diets was evaluated at week 1 of the study and the concentration in the low-dose also was determined at week 6 and 13. (europa.eu)
  • It is proposed to conclude that benzophenone does not meet the criteria under paragraphs 64(a) or (b) of CEPA as it is not entering the environment in a quantity or concentration or under conditions that have or may have an immediate or long-term harmful effect on the environment or its biological diversity or that constitute or may constitute a danger to the environment on which life depends. (canada.ca)
  • On the basis of the information presented in this draft screening assessment, it is proposed to conclude that benzophenone meets the criteria under paragraph 64(c) of CEPA as it is entering the environment in a quantity or concentration or under conditions that constitute or may constitute a danger in Canada to human life or health. (canada.ca)
  • Determination of benzotriazole and benzophenone UV filters in sediment and sewage sludge. (semanticscholar.org)
  • Estrogenic potency of benzophenone UV filters in breast cancer cells: proliferative and transcriptional activity substantiated by docking analysis. (inserm.fr)
  • while that of the propolis from Antioquia and Huila regions, were rich in prenylated benzophenones and triterpenes respectively (Table 1). (thefreedictionary.com)
  • One class of EDCs is the environmental phenols, which includes bisphenol A (BPA), triclosan (TCS), and benzophenone-3 (BP-3). (nih.gov)
  • The angiopreventive and in vitro tumor inhibition activities of novel synthetic benzophenone analogs have been investigated intensively and explored in a very systematic way. (rsc.org)
  • boiling point 305 - 306 C. Benzophenone is used as a constituent of synthetic perfumes and as a starting material for the manufacture of dyes, pesticides and drugs (especially anxiolytic and hypnotic drugs). (chemicalland21.com)
  • Benzophenone-3 (BP-3) is a naturally occurring chemical found in some flowering plants. (cdc.gov)
  • The aim of the present study was to evaluate the impact of biofield energy treatment on the thermal, spectroscopic, and chemical properties of benzophenone. (analchem.net)
  • By using TLC and IR spectrum, we will see the difference between benzophenone (starting material) and diphenylmethanol (final product). (antiessays.com)