BenzophenonesHistiocytic Disorders, Malignant: Distinctive neoplastic disorders of histiocytes. Included are malignant neoplasms of MACROPHAGES and DENDRITIC CELLS.Garcinia: A plant genus of the family CLUSIACEAE. Members contain XANTHONES.Thymelaeaceae: A plant family of the order Myrtales, subclass Rosidae, class Magnoliopsida. They are mainly trees and shrubs. Many members contain mucilage and COUMARINS.Photoaffinity Labels: Biologically active molecules which are covalently bound to the enzymes or binding proteins normally acting on them. Binding occurs due to activation of the label by ultraviolet light. These labels are used primarily to identify binding sites on proteins.Toxicity Tests, Chronic: Experiments designed to determine the potential toxic effects of a long-term exposure to a chemical or chemicals.Clusiaceae: The mangosteen plant family (sometimes classified as Guttiferae; also known as Hypericaceae) of the order THEALES, subclass Dilleniidae, class Magnoliopsida. It includes trees and shrubs with resinous, sticky sap, usually with broad-ended, oblong, leathery leaves with a strong, central vein, flowers with many stamens.Psidium: A plant genus of the family MYRTACEAE that bears an edible fruit and contains guavin B and quercetin glycosides.Sydnones: OXADIAZOLES bearing an oxygen at the 5-position. They are mesoionic, with delocalized positive and negative charges.Photosensitizing Agents: Drugs that are pharmacologically inactive but when exposed to ultraviolet radiation or sunlight are converted to their active metabolite to produce a beneficial reaction affecting the diseased tissue. These compounds can be administered topically or systemically and have been used therapeutically to treat psoriasis and various types of neoplasms.Acridones: Compounds based on acridone, which have three linear rings, with the center ring containing a ring nitrogen and a keto oxygen opposite to each other. Many of them are naturally occurring alkaloids.Carcinogenicity Tests: Tests to experimentally measure the tumor-producing/cancer cell-producing potency of an agent by administering the agent (e.g., benzanthracenes) and observing the quantity of tumors or the cell transformation developed over a given period of time. The carcinogenicity value is usually measured as milligrams of agent administered per tumor developed. Though this test differs from the DNA-repair and bacterial microsome MUTAGENICITY TESTS, researchers often attempt to correlate the finding of carcinogenicity values and mutagenicity values.Glycosides: Any compound that contains a constituent sugar, in which the hydroxyl group attached to the first carbon is substituted by an alcoholic, phenolic, or other group. They are named specifically for the sugar contained, such as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc. Upon hydrolysis, a sugar and nonsugar component (aglycone) are formed. (From Dorland, 28th ed; From Miall's Dictionary of Chemistry, 5th ed)Carbon-Carbon Ligases: Enzymes that catalyze the joining of two molecules by the formation of a carbon-carbon bond. These are the carboxylating enzymes and are mostly biotinyl-proteins. EC 6.4.Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Chromatography, Micellar Electrokinetic Capillary: A hybrid separation technique combining both chromatographic and electrophoretic separation principles. While the method was invented to separate neutral species, it can also be applied to charged molecules such as small peptides.Electrophoresis, Capillary: A highly-sensitive (in the picomolar range, which is 10,000-fold more sensitive than conventional electrophoresis) and efficient technique that allows separation of PROTEINS; NUCLEIC ACIDS; and CARBOHYDRATES. (Segen, Dictionary of Modern Medicine, 1992)Food Packaging: Containers, packaging, and packaging materials for processed and raw foods and beverages. It includes packaging intended to be used for storage and also used for preparation of foods such as microwave food containers versus COOKING AND EATING UTENSILS. Packaging materials may be intended for food contact or designated non-contact, for example, shipping containers. FOOD LABELING is also available.Pseudoephedrine: A phenethylamine that is an isomer of EPHEDRINE which has less central nervous system effects and usage is mainly for respiratory tract decongestion.Octanes: Eight-carbon saturated hydrocarbon group of the methane series. Include isomers and derivatives.Sodium Dodecyl Sulfate: An anionic surfactant, usually a mixture of sodium alkyl sulfates, mainly the lauryl; lowers surface tension of aqueous solutions; used as fat emulsifier, wetting agent, detergent in cosmetics, pharmaceuticals and toothpastes; also as research tool in protein biochemistry.Commerce: The interchange of goods or commodities, especially on a large scale, between different countries or between populations within the same country. It includes trade (the buying, selling, or exchanging of commodities, whether wholesale or retail) and business (the purchase and sale of goods to make a profit). (From Random House Unabridged Dictionary, 2d ed, p411, p2005 & p283)Taxes: Governmental levies on property, inheritance, gifts, etc.Prescription Fees: The charge levied on the consumer for drugs or therapy prescribed under written order of a physician or other health professional.Philately: Study of stamps or postal markings. It usually refers to the design and commemorative aspects of the stamp.Great BritainGermanyMedicine, Arabic: Traditional Arabic methods used in medicine in the ARAB WORLD.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Journal Impact Factor: A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Bibliometrics: The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)Peer Review, Research: The evaluation by experts of the quality and pertinence of research or research proposals of other experts in the same field. Peer review is used by editors in deciding which submissions warrant publication, by granting agencies to determine which proposals should be funded, and by academic institutions in tenure decisions.Bacteriology: The study of the structure, growth, function, genetics, and reproduction of bacteria, and BACTERIAL INFECTIONS.Authorship: The profession of writing. Also the identity of the writer as the creator of a literary production.Xylitol: A five-carbon sugar alcohol derived from XYLOSE by reduction of the carbonyl group. It is as sweet as sucrose and used as a noncariogenic sweetener.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Biofuels: Hydrocarbon-rich byproducts from the non-fossilized BIOMASS that are combusted to generate energy as opposed to fossilized hydrocarbon deposits (FOSSIL FUELS).Body Composition: The relative amounts of various components in the body, such as percentage of body fat.Tablets: Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)Excipients: Usually inert substances added to a prescription in order to provide suitable consistency to the dosage form. These include binders, matrix, base or diluent in pills, tablets, creams, salves, etc.Foramen Ovale, Patent: A condition in which the FORAMEN OVALE in the ATRIAL SEPTUM fails to close shortly after birth. This results in abnormal communications between the two upper chambers of the heart. An isolated patent ovale foramen without other structural heart defects is usually of no hemodynamic significance.Resins, Plant: Flammable, amorphous, vegetable products of secretion or disintegration, usually formed in special cavities of plants. They are generally insoluble in water and soluble in alcohol, carbon tetrachloride, ether, or volatile oils. They are fusible and have a conchoidal fracture. They are the oxidation or polymerization products of the terpenes, and are mixtures of aromatic acids and esters. Most are soft and sticky, but harden after exposure to cold. (From Grant & Hackh's Chemical Dictionary, 5th ed & Dorland, 28th ed)Carboxylic Acids: Organic compounds containing the carboxy group (-COOH). This group of compounds includes amino acids and fatty acids. Carboxylic acids can be saturated, unsaturated, or aromatic.Biomedical Technology: The application of technology to the solution of medical problems.Colorimetry: Any technique by which an unknown color is evaluated in terms of standard colors. The technique may be visual, photoelectric, or indirect by means of spectrophotometry. It is used in chemistry and physics. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Composite Resins: Synthetic resins, containing an inert filler, that are widely used in dentistry.Quaternary Ammonium Compounds: Derivatives of ammonium compounds, NH4+ Y-, in which all four of the hydrogens bonded to nitrogen have been replaced with hydrocarbyl groups. These are distinguished from IMINES which are RN=CR2.Benzalkonium Compounds: A mixture of alkylbenzyldimethylammonium compounds. It is a bactericidal quaternary ammonium detergent used topically in medicaments, deodorants, mouthwashes, as a surgical antiseptic, and as a as preservative and emulsifier in drugs and cosmetics.Disinfectants: Substances used on inanimate objects that destroy harmful microorganisms or inhibit their activity. Disinfectants are classed as complete, destroying SPORES as well as vegetative forms of microorganisms, or incomplete, destroying only vegetative forms of the organisms. They are distinguished from ANTISEPTICS, which are local anti-infective agents used on humans and other animals. (From Hawley's Condensed Chemical Dictionary, 11th ed)Amines: A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dictionary, 5th ed)Iodine Compounds: Inorganic compounds that contain iodine as an integral part of the molecule.Cetylpyridinium: Cationic bactericidal surfactant used as a topical antiseptic for skin, wounds, mucous membranes, instruments, etc.; and also as a component in mouthwash and lozenges.

Solid-phase microextraction and GC-ECD of benzophenones for detection of benzodiazepines in urine. (1/275)

Benzodiazepines are common drugs that cause intoxication. Benzodiazepines and their metabolites can be converted by hydrolysis in acid to the corresponding benzophenones, which are easier to be separated from matrices because of their hydrophobic properties. In this study, a new separation technique called solid-phase microextraction (SPME), which can integrate extraction, concentration, sampling and sample introduction into one single procedure, has been employed to extract the products of benzodiazepines from urine after acid hydrolysis. The extracts were determined by gas chromatography with electron-capture detection (GC-ECD). The hydrolysis conditions were optimized by a statistic orthogonal design. Factors influencing direct-immersion (DI)-SPME process were also checked and chosen experimentally. The method was evaluated with spiked human urine samples. The recoveries of nine benzodiazepines ranged from 1 to 25%, with the highest for oxazolam and the lowest for bromazepam. The calibration curves were linear from 10 to 500 ng/mL for oxazolam, haloxazolam, flunitrazepam, nimetazepam, and clonazepam and from 20 to 1000 ng/mL for the others except bromazepam. The detection limits were 2-20 ng/mL for most drugs tested. The intraday and interday coefficients of variation of the developed method were within 10 and 17%, respectively. In addition, the utility of the method was confirmed by determining two ingested benzodiazepines (flunitrazepam and oxazolam) in a volunteer's urine; urine flunitrazepam was still detectable 32 h after a therapeutic dose (1.2 mg) of the drug. Finally, the DI-SPME was compared with the conventional liquid-liquid extraction with regard to detection limits and extraction efficiency of the analytes. By DI-SPME, more amounts of analytes could be introduced into GC column than by conventional liquid-liquid extraction, and thus lower detection limits of the analytes were reached, although benzophenone recoveries by DI-SPME were rather low.  (+info)

Mechanism of regulation of hsp70 chaperones by DnaJ cochaperones. (2/275)

Hsp70 chaperones assist a large variety of protein folding processes within the entire lifespan of proteins. Central to these activities is the regulation of Hsp70 by DnaJ cochaperones. DnaJ stimulates Hsp70 to hydrolyze ATP, a key step that closes its substrate-binding cavity and thus allows stable binding of substrate. We show that DnaJ stimulates ATP hydrolysis by Escherichia coli Hsp70, DnaK, very efficiently to >1000-fold, but only if present at high (micromolar) concentration. In contrast, the chaperone activity of DnaK in luciferase refolding was maximal at several hundredfold lower concentration of DnaJ. However, DnaJ was capable of maximally stimulating the DnaK ATPase even at this low concentration, provided that protein substrate was present, indicating synergistic action of DnaJ and substrate. Peptide substrates were poorly effective in this synergistic action. DnaJ action required binding of protein substrates to the central hydrophobic pocket of the substrate-binding cavity of DnaK, as evidenced by the reduced ability of DnaJ to stimulate ATP hydrolysis by a DnaK mutant with defects in substrate binding. At high concentrations, DnaJ itself served as substrate for DnaK in a process considered to be unphysiological. Mutant analysis furthermore revealed that DnaJ-mediated stimulation of ATP hydrolysis requires communication between the ATPase and substrate-binding domains of DnaK. This mechanism thus allows DnaJ to tightly couple ATP hydrolysis by DnaK with substrate binding and to avoid jamming of the DnaK chaperone with peptides. It probably is conserved among Hsp70 family members and is proposed to account for their functional diversity.  (+info)

Comparison of the potassium channel openers, WAY-133537, ZD6169, and celikalim on isolated bladder tissue and In vivo bladder instability in rat. (3/275)

The effects of the ATP-dependent potassium channel agonists ZD6169, celikalim, and WAY-133537 on bladder contractile function were examined in vitro on isolated bladder strips and in vivo on spontaneous bladder contractions. All three compounds produced a concentration-dependent relaxation of isolated rat detrusor strips (IC50 values = 0.93, 0.03, and 0.09 microM, respectively for ZD6169, celikalim, and WAY-133537. Contractile inhibition by all three compounds was fully reversed by 6 microM glyburide. These compounds also effectively inhibited spontaneous bladder contractions in the rat hypertrophied bladder model of detrusor instability. We also examined the electrophysiological properties of WAY-133537 on isolated rat bladder detrusor myocytes. Myocytes had an average resting membrane potential of -40 mV. Under patch current-clamp conditions, WAY-133537 (0.3 and 1.0 microM, n = 4-5) produced a significant hyperpolarization of 21 and 26 mV, respectively. Hyperpolarization was reversed by the addition of 5 microM glyburide. In patch voltage-clamp studies, WAY-133537 (0.3 microM, n = 3) significantly increased outward current in response to both voltage step and ramp protocols consistent with activation of the ATP-dependent potassium channel. In the detrusor instability model, WAY-133537 and celikalim had similar oral potencies (ED50 = 0.13 and 0.3 mg/kg, respectively), whereas ZD6169 was less potent (ED50 = 2.4 mg/kg). The antihypertensive agent celikalim exerted effects on the bladder at doses that significantly reduced systemic blood pressure. In contrast, both WAY-133537 and ZD6169 inhibited bladder hyperactivity at doses that produced minimal changes in both mean arterial blood pressure and heart rate. These data suggest that both WAY-133537 and ZD6169 may be useful in the treatment of bladder instability at doses associated with minimal hemodynamic side effects.  (+info)

Guanosine triphosphatase stimulation of oncogenic Ras mutants. (4/275)

Interest in the guanosine triphosphatase (GTPase) reaction of Ras as a molecular drug target stems from the observation that, in a large number of human tumors, Ras is characteristically mutated at codons 12 or 61, more rarely 13. Impaired GTPase activity, even in the presence of GTPase activating proteins, has been found to be the biochemical reason behind the oncogenicity of most Gly12/Gln61 mutations, thus preventing Ras from being switched off. Therefore, these oncogenic Ras mutants remain constitutively activated and contribute to the neoplastic phenotype of tumor cells. Here, we show that the guanosine 5'-triphosphate (GTP) analogue diaminobenzophenone-phosphoroamidate-GTP (DABP-GTP) is hydrolyzed by wild-type Ras but more efficiently by frequently occurring oncogenic Ras mutants, to yield guanosine 5'-diphosphate-bound inactive Ras and DABP-Pi. The reaction is independent of the presence of Gln61 and is most dramatically enhanced with Gly12 mutants. Thus, the defective GTPase reaction of the oncogenic Ras mutants can be rescued by using DABP-GTP instead of GTP, arguing that the GTPase switch of Ras is not irreversibly damaged. An exocyclic aromatic amino group of DABP-GTP is critical for the reaction and bypasses the putative rate-limiting step of the intrinsic Ras GTPase reaction. The crystal structures of Ras-bound DABP-beta,gamma-imido-GTP show a disordered switch I and identify the Gly12/Gly13 region as the hydrophobic patch to accommodate the DABP-moiety. The biochemical and structural studies help to define the requirements for the design of anti-Ras drugs aimed at the blocked GTPase reaction.  (+info)

The binding site for an inhibitor of squalene:hopene cyclase determined using photoaffinity labeling and molecular modeling. (5/275)

BACKGROUND: The squalene:hopene cyclases (SHCs) are bacterial enzymes that convert squalene into hopanoids, a function analogous to the action of oxidosqualene cyclases (OSCs) in eukaryotic steroid and triterpenoid biosynthesis. We have identified the binding site for a selective, potent, photoactivatable inhibitor of an SHC. RESULTS: SHC from Alicyclobacillus acidocaldarius was specifically labeled by [3H]Ro48-8071, a benzophenone-containing hypocholesteremic drug. Edman degradation of a peptide fragment of covalently modified SHC confirmed that Ala44 was specifically modified. Molecular modeling, using X-ray-derived protein coordinates and a single point constraint for the inhibitor, suggested several geometries by which Ro48-8071 could occupy the active site. CONCLUSIONS: A covalent complex of a potent inhibitor with a squalene cyclase has been characterized. The amino acid modification and molecular modeling suggest that Ro48-8071 binds at the junction between the central cavity and substrate entry channel, therefore inhibiting access of the substrate to the active site.  (+info)

A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat. (6/275)

The discovery that peroxisome proliferator-activated receptor (PPAR)-gamma was the molecular target of the thiazolidinedione class of antidiabetic agents suggested a key role for PPAR-gamma in the regulation of carbohydrate and lipid metabolism. Through the use of high-throughput biochemical assays, GW1929, a novel N-aryl tyrosine activator of human PPAR-gamma, was identified. Chronic oral administration of GW1929 or troglitazone to Zucker diabetic fatty (ZDF) rats resulted in dose-dependent decreases in daily glucose, free fatty acid, and triglyceride exposure compared with pretreatment values, as well as significant decreases in glycosylated hemoglobin. Whole body insulin sensitivity, as determined by the euglycemic-hyperinsulinemic clamp technique, was significantly increased in treated animals. Comparison of the magnitude of glucose lowering as a function of serum drug concentrations showed that GW1929 was 2 orders of magnitude more potent than troglitazone in vivo. These data were consistent with the relative in vitro potencies of GW1929 and troglitazone. Isolated perfused pancreas studies performed at the end of the study confirmed that pancreata from vehicle-treated rats showed no increase in insulin secretion in response to a step change in glucose from 3 to 10 mmol/l. In contrast, pancreata from animals treated with GW1929 showed a first- and second-phase insulin secretion pattern. Consistent with the functional data from the perfusion experiments, animals treated with the PPAR-gamma agonist had more normal islet architecture with preserved insulin staining compared with vehicle-treated ZDF rats. This is the first demonstration of in vivo efficacy of a novel nonthiazolidinedione identified as a high-affinity ligand for human PPAR-gamma. The increased potency of GW1929 compared with troglitazone both in vitro and in vivo may translate into improved clinical efficacy when used as monotherapy in type 2 diabetic patients. In addition, the significant improvement in daily meal tolerance may impact cardiovascular risk factor management in these patients.  (+info)

Effects of ZD6169, a K(ATP) channel opener, on the micturition reflex in the rat. (7/275)

The effects of ZD6169, a new ATP-sensitive potassium channel opener, on reflex urinary bladder activity were evaluated in urethane-anesthetized female Wistar rats. Continuous transvesical slow infusion cystometrograms (0.04 ml/min) were performed in untreated, capsaicin-pretreated (125 mg/kg s.c., 4 days before experiments) and capsaicin vehicle-pretreated rats. Intravesical infusion of ZD6169 in concentrations of 6, 15, 30, and 300 nM for 2 h at each concentration increased the intercontraction interval and pressure threshold for voiding in a concentration-dependent manner in untreated and vehicle-pretreated rats but not in capsaicin-pretreated animals. The effects appeared within 30 min after administration. ZD6169 did not alter baseline bladder pressure, duration of contractions, or the peak pressure during voiding. Glibenclamide (20 mg/kg i.v.) reversed the effects of ZD6169 (30 nM). During transvesical cystometrograms performed at a fast rate (0.21 ml/min), ZD6169 in concentrations between 6 and 300 nM did not alter the intercontraction interval or pressure threshold for voiding. ZD6169 produced smaller and more variable effects during slow transurethral cystometrograms. Capsaicin, a C-fiber afferent neurotoxin, administered s.c. 4 days before the experiment, produced similar changes and also eliminated the effect of ZD6169. These data suggest that ZD6169 raises the threshold for activation of C-fiber mechanoreceptors in the bladder wall and thereby increases the bladder volume for inducing reflex voiding.  (+info)

Differential and selective inhibition of protein kinase A and protein kinase C in intact cells by balanol congeners. (8/275)

The fungal metabolite balanol is a potent inhibitor of protein kinase A (PKA) and protein kinase C (PKC) in vitro that acts by competing with ATP for binding (K(i) approximately 4 nM); congeners of balanol show specificity for PKA over PKC. We have characterized the effects of balanol and 10"-deoxybalanol in intact cells to determine whether these compounds cross the cell membrane and whether the potency and specificity noted in vitro are preserved in vivo. In neonatal rat myocytes and cultured A431 cells transiently transfected with a cyclic AMP response element-luciferase reporter construct, balanol inhibits the induction of luciferase activity by isoproterenol, indicating inhibition of PKA. Western analysis shows that both balanol and 10"-deoxybalanol reduce phosphorylation of cAMP response element-binding protein in isoproterenol-stimulated A431 cells; inhibition is concentration dependent with an IC(50) value of approximately 3 microM. Balanol, but not 10"-deoxybalanol, inhibits phosphorylation of the myristoylated alanine-rich C kinase substrate protein, a PKC substrate, in phorbol ester-stimulated A431 cells (IC(50) approximately 7 microM). Our data demonstrate that balanol is a potent inhibitor of PKA and PKC in several whole-cell systems and causes no obvious toxicity. In addition, balanol congeners inhibit PKA and PKC with the specificity and potency predicted by in vitro experiments.  (+info)

*Benzophenone

... is a widely used building block in organic chemistry, being the parent diarylketone. Benzophenone can be used as a ... In 2014, benzophenones were named Contact Allergen of the Year by the American Contact Dermatitis Society. Benzophenone is an ... Another, less well-known reaction to produce benzophenone is the pyrolysis of anhydrous calcium benzoate. Benzophenone is a ... The high-strength polymer PEEK is prepared from derivatives of benzophenone. Benzophenone derivatives are known to be ...

*Benzophenone synthase

In enzymology, a benzophenone synthase (EC 2.3.1.151) is an enzyme that catalyzes the chemical reaction 3 malonyl-CoA + 3- ... Beerhues L (1996). "Benzophenone synthase from cultured cells of Centaurium erythraea". FEBS Lett. 383 (3): 264-6. doi:10.1016/ ...

*Benzophenone-n

Benzophenone-10 (mexenone, 2-hydroxy-4-methoxy-4'-methyl-benzophenone) Benzophenone-11 (benzophenone-2 and benzophenone-6) ... Benzophenone-3 (oxybenzone) Benzophenone-4 (sulisobenzone) Benzophenone-5 (sulisobenzone sodium) Benzophenone-6 (2,2'-dihydroxy ... Benzophenone-12 (octabenzone, used to protect plastics) Chemicalland21: Benzophenone Inhaltsstoffe Kosmetik: Benzophenone-11 ( ... 4'-dimethoxybenzophenone) Benzophenone-7 (5-chloro-2-hydroxybenzophenone) Benzophenone-8 (dioxybenzone) Benzophenone-9 (sodium ...

*Allergen of the Year

Heurung, Ashley R.; Raju, Srihari I.; Warshaw, Erin M. (2014). "Benzophenones". Dermatitis. 25 (1): 3-10. doi:10.1097/DER. ... Benzophenones 2013 - Methylisothiazolinone - This chemical is used as a preservative in many cosmetics, lotions, and makeup ... 2014). http://www.skinandallergynews.com/single-view/benzophenones-named-2014-contact-allergen-of-the-year/ ...

*Diphenyldichloromethane

Alternatively, benzophenone is treated with phosphorus pentachloride: (C6H5)2CO + PCl5 → (C6H5)2CCl2 + POCl3 It undergoes ... Andrews, L. J.; W. W. Kaeding (1951). "The Formation of Benzophenone and its Diethylketal in the Ethanolysis of ... Marvel, C. S.; Sperry, W. M. (1941). "Benzophenone". Organic Syntheses. CS1 maint: Multiple names: authors list (link) ; ... hydrolysis to benzophenone. (C6H5)2CCl2 + H2O → (C6H5)2CO + 2 HCl It is used in the synthesis of tetraphenylethylene, ...

*Photoelectrochemical process

Cadmium; some of the noble gases, for example xenon; zinc; benzophenone; and a large number of organic dyes, are also used as ...

*Geminal halide hydrolysis

Stephen aldehyde synthesis Marvel, C. S.; Sperry, W. M. (1928). "Benzophenone". Organic Syntheses. 8: 26. doi:10.15227/orgsyn. ...

*Ketone

Acetone and benzophenone (C6H5C(O)C6H5) are symmetrical ketones. Acetophenone (C6H5C(O)CH3) is an asymmetrical ketone. In the ... "Benzophenone". Organic Syntheses. 8: 26. doi:10.15227/orgsyn.008.0026. Furniss, Brian; Hannaford, Antony; Smith, Peter; ... for example acetone and benzophenone. These nonsystematic names are considered retained IUPAC names, although some introductory ...

*Propolis

Clusia resin contains polyprenylated benzophenones. In some areas of Chile, propolis contains viscidone, a terpene from ...

*Photoprotection

see Benzophenone). This discrepancy between melanin and sunscreen ingredients is one of the reasons for the increased melanoma ...

*Oxybenzone

Benzophenones can leach from food packaging, and are widely used as photo-initiators to activate a chemical that dries ink ... Oxybenzone or benzophenone-3 (trade names Milestab 9, Eusolex 4360, Escalol 567, KAHSCREEN BZ-3) is an organic compound. It is ... Benzophenones (along with three other active ingredients)[which?] in sunscreens have been linked to coral bleaching. A 2015 ... Okereke, C. S.; Kadry, A. M.; Abdel-Rahman, M. S.; Davis, R. A.; Friedman, M. A. (1993). "Metabolism of benzophenone-3 in rats ...

*Dioxybenzone

... (benzophenone-8) is an organic compound used in sunscreen to block UVB and short-wave UVA (ultraviolet) rays. It ... is a derivative of benzophenone. It is a yellow powder with a melting point of 68 °C. It is insoluble in water, but moderately ...

*Diazirine

Benzophenones, which form reactive triplet carbonyl species upon irradiation, often require long periods of irradiation which ... Prestwich, Glenn D.; Dormán, György; Elliott, John T.; Marecak, Dale M.; Chaudhary, Anu (1997-02-01). "Benzophenone Photoprobes ...

*Thioketone

It photooxidizes in air to benzophenone and sulfur. Since its discovery, a variety of related thiones have been prepared. ...

*Ionic hydrogenation

Ketones such as benzophenones, and 1,1-disubstituted olefins are typical substrates. Hydrides of tungsten, chromium, osmium, ...

*Balanol

Specifically, balanol's distal benzophenone ring is able to rotate. In fact, in complex with PKA, balanol's distal benzophenone ... The benzophenone and hexahydroazepane moieties are connected via an ester linkage, and the azepane and benzoyl moieties are ... For instance, balanol's benzophenone rings are positioned beside the glycine-rich loop and further from the more polar ... For instance, balanol's benzophenone ring interacts with numerous highly conserved residues in PKA such as Gly52, Phe54, Asp184 ...

*Photolabile protecting group

Pirrung, M. C.; Roy, B. G.; Gadamsetty, S. (April 2010). "Structure-Reactivity Relationships in (2-Hydroxyethyl)benzophenone ...

*Peroxide process

A similar process based on benzophenone has also been described. The final stage involves hydrolysis of the purified ketazine: ...

*Photodegradation

Typical UV-absorbers are hydroxy-substituted benzophenones, related to the chemicals used in sunscreen. Polymer degradation UV ...

*Haloxazolam

"Solid-phase microextraction and GC-ECD of benzophenones for detection of benzodiazepines in urine". Journal of analytical ...

*Melipona scutellaris

The characteristics shown by chemical analyses suggest the presence of benzophenones as active compounds. Therefore, ...

*Air-free technique

Benzophenone is often used to generate such a soluble drying agent. An advantage to this application is the intense blue color ... Thus, sodium/benzophenone can be used as an indicator of air-free and moisture-free conditions in the purification of solvents ...

*Radical ion

Benzophenone is reduced to the ketyl radical anion by sodium which gives the THF solution an intense blue color. However, any ... ISBN 0-9660813-2-3. The Benzophenone Ketyl Still Pot - [www.rhodium.ws] Solomon, I. J.; Brabets, R. I.; Uenishi, R. K.; Keith, ... way to remove any traces of water from THF is by reflux with sodium wire in the presence of a small amount of benzophenone. ...

*Benzoyl group

They have the formula C6H5CO-R, an important example being benzophenone. Benzoyl esters and amides are common in organic ...

*Wolff-Kishner reduction

6. Comparison of the hydrazones of benzophenone, fluorenone, dibenzotropone, and dibenzosuberone". The Journal of Organic ... "The Effect of Dimethyl Sulfoxide on the Rate of the Wolff-Kishner Reaction of Benzophenone Hydrazone1". Journal of the American ...
Recent evidence suggests that prepulse inhibition (PPI) levels relate to executive function possibly by a prefrontal cortex (PFC) dopamine (DA) link. We explored the effects of enhanced PFC DA signaling by the nonstimulant catechol-O-methyltransferase (COMT) inhibitor tolcapone, on PPI and working memory of subjects homozygous for the Val (low PFC DA) and the Met (high PFC DA) alleles of the COMT Val158Met polymorphism. Twelve Val/Val and eleven Met/Met healthy male subjects entered the study. Tolcapone 200 mg was administered in two weekly sessions, according to a balanced, crossover, double-blind, placebo-controlled design. PPI was assessed with 5 dB and 15 dB above background prepulses, at 30-, 60-, and 120 ms prepulse-pulse intervals. Subjects also underwent the n-back and the letter-number sequencing (LNS) tasks. PPI was lower in the Val/Val compared to the Met/Met group in the placebo condition. Tolcapone increased PPI significantly in the Val/Val group and tended to have the opposite effect in
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The present study confirms and extends previous findings28 29 that tolcapone enhances the efficacy of levodopa. Whereas initial studies were focused on single dose6 or short term (one to six weeks) multiple dose22 26 coadministration of tolcapone with levodopa/decarboxylase inhibitor, the present study showed that multiple dose (tid) treatment with tolcapone results in reduced severity of "wearing off" type motor fluctuations in levodopa treated patients for three months and that this response is maintained over time.. Treatment with tolcapone significantly decreased mean "off" time (by ,20%) and increased mean "on" time (by ,25%), compared with placebo. Analysis of primary end point "on/off" data disclosed that both tolcapone dosages were equally effective in increasing "on" time, but the 100 mg tid dosage was more effective in decreasing "off" time. However, the mean reduction in levodopa dosage by month 3 was greater with 200 mg tolcapone tid than with 100 mg tid This reduction was maintained ...
The hydrogen abstraction reaction of benzophenones in micellar interiors was studied by the effect of a short, resonant microwave pulse on the recombination kinetics under magnetic fields of approximately 0.3 T. This technique allows all the significant rate constants in the reaction to be determined, in particular the singlet state recombination rate constant, which is very difficult to accurately determine by other techniques. This is determined to be 1.90 × 107 s-1 for benzophenone (BP) and 1.83 × 107 s-1 for decafluorobenzophenone in sodium dodecyl sulfate (SDS) micelles, indicating that this value is not limited by the rate of spin mixing, and thus that the kinetic approach used is justified. It also indicates that recombination is limited by re-encounter frequency and is not dependent upon substitution in the ketyl radical. All kinetic parameters are extracted for each system using a combination of single pulse and pulse shift measurements. Data are also presented for the reactions of BP ...
Benzophenone occurs naturally in some fruits and is used commercially as a perfumery and flavoring ingredient. This study was performed in response to the potential for human exposure and the lack of pertinent developmental toxicity data. Dose selection was based on a screening study in which Sprague-Dawley-derived (CD) rats were treated by gavage with benzophenone (0, 25, 50, 100, 200, or 300 mg/kg body weight/day) on gestational days 6 through 19 (NTP, 1998b). Maternal toxicity was found at all doses, but evidence of developmental toxicity was limited to a 6-8% decrease for average fetal body weight per litter (not statistically significant) at the high dose. In this study, benzophenone (100, 200, or 300 mg/kg/day) or its vehicle (0.5% methylcellulose) was administered to female CD rats by gavage on gd 6 through 19. The dose volume was 5 ml/kg. Twenty-five to 26 timed-mated rats were assigned to each group. Dams were monitored at regular intervals throughout gestation for clinical signs, feed ...
Product Details of 2-benzoyl-5-methoxy-1-phenol-4-sulfonic acid CAS 4065-45-6 BP-4. 2-Hydroxy-4-Methoxy Benzophenone-5-Sulfonic acid, 2-benzoyl-5-methoxy-1-phenol-4-sulfonic acid CAS 4065-45-6 BP-4. 2-Hydroxy-4-Methoxy Benzophenone-5-Sulfonic acid from China manufacturer on Hisupplier.com.
Oxybenzone (2-hydroxy-4-methoxyphenone, benzophenone-3) is one of the UV filters commonly found in sunscreens. Its presence in swimming pools and its reactivity with chlorine has already been demonstrated but never in seawater swirnrning pools. In these pools, chlorine added for disinfection results in the formation of bromine, due to the high levels of bromide in seawater, and leads to the formation of brominated disinfection byproducts, known to be more toxic than chlorinated ones. Therefore, it seems important to determine the transformation products of oxybenzone in chlorinated seawater swimming pools; especially that users of seawater swimming pools may apply sunscreens and other personal-care products containing oxybenzone before going to pools. This leads to the introduction of oxybenzone to pools, where it reacts with bromine. For this purpose, the reactivity of oxybenzone has been examined as a function of chlorine dose and temperature in artificial seawater to assess its potential to ...
Tolcapone (brand name Tasmar) is a drug used to treat Parkinsons disease (PD). It is a selective, potent and reversible nitrocatechol-type inhibitor of the enzyme catechol-O-methyltransferase (COMT). It has demonstrated significant liver toxicity, which has led to suspension of marketing authorisations in a number of countries. In comparison with entacapone, another nitrocatechol COMT inhibitor, tolcapone has a longer half life (2.9 hours vs. 0.8 hours) and can better penetrate the blood-brain barrier, acting both in the central nervous system and in the periphery. However, entacapone is less toxic for the liver. Tolcapone is used in the treatment of Parkinsons disease as an adjunct to levodopa/carbidopa or levodopa/benserazide medications. Levodopa is a prodrug for dopamine, which reduces Parkinson symptoms; carbidopa and benserazide are aromatic L-amino acid decarboxylase (AADC) inhibitors. Without administration of tolcapone, the beneficial effects of levodopa tend to wear off more quickly, ...
Catechol-O-methyltransferase (COMT) modulates dopamine levels in the prefrontal cortex. The human gene contains a polymorphism (Val158Met) that alters enzyme activity and influences PFC function. It has also been linked with cognition and anxiety, but the findings are mixed. We therefore developed a novel mouse model of altered COMT activity. The human Met allele was introduced into the native mouse COMT gene to produce COMT-Met mice, which were compared with their wild-type littermates. The model proved highly specific: COMT-Met mice had reductions in COMT abundance and activity, compared with wild-type mice, explicitly in the absence of off-target changes in the expression of other genes. Despite robust alterations in dopamine metabolism, we found only subtle changes on certain cognitive tasks under baseline conditions (eg, increased spatial novelty preference in COMT-Met mice vs wild-type mice). However, genotype differences emerged after administration of the COMT inhibitor tolcapone: performance of
Benzophenone-4-iodoacetamide | C15H12INO2 | CID 131289 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Interactions of benzophenone (BP) with the Torpedo nicotinic acetylcholine receptor (nAChR) were characterized by electrophysiological analyses, radioligand binding assays, and photolabeling of nAChR-rich membranes with [3H]BP to identify the amino acids contributing to its binding sites. BP acted as a low potency noncompetitive antagonist, reversibly inhibiting the ACh responses of nAChRs expressed in Xenopus oocytes (IC50 = 600 卩 and the binding of the noncompetitive antagonist [3H]tetracaine to nAChR-rich membranes (IC50 = 150 卩. UV irradiation at 365 nm resulted in covalent incorporation of [3H]BP into the nAChR subunits (d , a ߠ, ?), with photoincorporation limited to the nAChR transmembrane domain. Comparison of nAChR photolabeling in the closed state (absence of agonist) and desensitized state (equilibrated with agonist) revealed selective desensitized state labeling in the d subunit of dPhe-232 in dM1 and dPro-286/dIle-288 near the beginning of dM3 that are within a pocket at the ...
2-Fluoro-2-(3-pyrrolinomethyl)benzophenone/ACM898763503 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
Extracted from pure natural materials, this benzophenone 3 is very popular among customers and also enjoys strong reputation due to its high quality and competitive price. Come and choose one you like.
McMurry reactions of (η5-acetylcyclopentadienyl) cobalt-(η4-tetraphenylcyclobutadiene) with benzophenone: ketone couplings and a pinacol/pinacolone rearrangement Conference Paper ...
Creative-Proteomics offer cas 119-61-9 BENZOPHENONE UNLABELED 100 UG/ML IN NONANE. We are specialized in manufacturing Stabel Isotope Labeled Analytical Standard products.
Sigma-Aldrich offers Aldrich-454168, 4-Fluoro-4′-(phenylethynyl)benzophenone for your research needs. Find product specific information including CAS, MSDS, protocols and references.
Naveen, P. and Rekha, N. D. and Lakshmi Ranganatha, V. and Bushra Begum, A. and Shaukath Ara Khanum, (2017) Synthesis of salicylic acid fused dihydropyrazole analogues and their mechanism of action on escherichia coli cells. Der Pharma Chemica, 9 (16). pp. 91-97. ISSN 0975-413X Shamanth Neralagundi, H. G. and Bushra Begum, A. and Prabhakar, B. T. and Khanum, Shaukath Ara (2016) Design and synthesis of diamide-coupled benzophenones as potential anticancer agents. European Journal of Medicinal Chemistry, 115. pp. 342-351. ISSN 0223-5234 Zabiulla, and Naveen, S. and Bushra Begum, A. and Khanum, Shaukath Ara and Lokanath, N. K. (2016) Structural studies of a novel bioactive benzophenone derivative: (4-Chloro-2-hydroxy-phenyl)-phenyl-methanone. Molecular Crystals and Liquid Crystals, 625 (1). pp. 233-237. ISSN 1542-1406 Mohammed, Al-Ghorbani and Bushra Begum , A. and Mamatha Zabiulla, S. V. and Shaukath Ara Khanum, (2015) Piperazine and Morpholine: SyntheticpPreview and pharmaceutical applications. ...
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Tolcapone; Tolcapone may be used in COMT-mediated cell signaling studies. Tolcapone has been used in methyltransferase assay in human embryonic kidney 293 cells.
In an appropriate sized vessel, weigh out the water and the Carbopol Ultrez-21. Allow the Carbopol Ultrez-21 to completely hydrate without mixing. Once the hydration is completed, begin mixing the batch. Add the Drieline, MDI Complex, alpha-Bisabolol, Wacker Belsil DMC6031, VitaCon AEM, SilSense A-23 and Merguard 1190 while mixing the batch. Continue mixing until uniform. In a separate vessel, prepare the sunscreen pre-blend by combining the SD 40B Alcohol, Hallbrite OS, EI OMC, Benzophenone-3, Floramac 10 and Fragrance. Mix this pre-blend until all of the Benzophenone-3 has dissolved and the blend is uniform. Add the sunscreen pre-blend to the batch with mixing. Mix the batch until it is uniform. Add the TEA to the batch with mixing. Once the batch is uniform, add the Merquat 3330 and mix the batch until uniform ...
In this research intermolecular and intramolecular triplet sensitization has been employed to photochemically generate triplet alkyl nitrene intermediates in solution. Photolyzing with light greater than 300 nm assures that only the ketone chromophore is exclusively excited to its triplet excited state. Once generated, the ketone can transfer its triplet energy to the azide moiety which loses molecular nitrogen to give a triplet alkyl nitrene intermediate. Intermolecular triplet sensitization in solution allowed trapping of triplet alkyl nitrene intermediates via bimolecular reactions. Photolysis of 1-azidoadamantane in solution with acetophenone, benzophenone and acetone led to an azo-dimer as the major product. This product comes from dimerization of two triplet alkyl nitrenes. Intermolecular sensitized photolysis of benzyl azide led to N-methyleneaniline as the major photoproduct with acetophenone as the triplet sensitizer. With benzophenone as the triplet sensitizer the major product was ...
Pharmaceutical Raw Material Ultraviolet absorbent UV-531 CAS: 1843-05-6 Basic Info. Name:Ultraviolet absorbent UV-531 Synonym: OCTABENZONE 2-HYDROXY-4-OCTYLOXY BENZOPHENONE BP-12 UV-531 2-HYDROXY-4-N-OCTOXY BENZOPHENONE UV ABOSORBER 531...
Dose: PRELIM: Rat: iv: 2.5 mg/kg, gavage: 2.5 and 10 mg/kg mice: iv: 15 mg/kg, gavage: 15 and 60 mg/kg TK study: feed: 312 & 1250ppm for both; iv: 2.5 mg/kg(rat), 15mg/kg(mouse); and gavage: 2.5, 5, 10 mg/kg(rat) and 15, 30, 60mg/kg(mouse ...
4] a ) J. T. Kauer, S. Erickson-Vitanen, H. R. Wolfe, W. F. De Grddo, J B d . Chrm. 1986.261. 10695, b) W. T. Miller, E. T. Kaiser. Proc. Nurl. Arud. Sci. U S A 1988, K S , 5429. c) T. Tao. C. J. Schemer, M. Lamkin. 5io~liemistr.v 1986.2.7. 7633. [5] a ) R. Breslow, Acr. Chrm. Res. 1980, 13, 170, b) C . Helene, Phofochem. Pholohiol. 1972, 16. 519. [6] G. W. Anderson, J. E. Zimmerman. F. M. Gallahan, J. Am. Cheni. Sor. 1964. K6. 1839. [7] A section of a silica substrate bearing nitroveratryloxycarbonyl(NV0C)protected amino groups was photodeprotected [3] and then derivatized uith the NHS ester of 3-benzoylbenzoic acid. A second section of the substrate was then deprotected and derivatized with the NHS ester of biotin. Any unreacted sites in the first section (due to incomplete coupling of benzophenone) will also react with the biotin NHS ester. The entire surface was then treated with fluorescein-streptavidin (Molecular Probes lnc.. Eugene. O R (USA)). The coupling efficiency of benzophenone was ...
Medium hold styling product with no shine. Styles and controls hair to create the look you want with a matte finish. Specially formulated with Panthenol to improve hairs health and thickness. Benzophenones enhance the products performance by shielding against environmental elements, so you get looks that last.. Application: Apply liberally to damp hair and style hair into final shape. Brush through once dry to activate matte finish.. Features: D-Panthenol, Sodium PCA, Benzophenones, Hydrolyzed Wheat Protein, Acrylates Crosspolymer-3, Silica.. Benefits: Prevents from hair damage, thickens hair and acts as a long-lasting moisturizer. Promotes moisture retention. Provides protection against the effects of ultraviolet rays and natures visible components on hair. Enhances hairs body and shine while acting as an excellent moisturizing and permanent conditioning agent. Offers medium hold, long-lasting results with humidity resistance and no flakes. Weightless, white ingredient used to achieve the ...
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Runoff from fire control or dilution water may cause pollution. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam. Use agent most appropriate to extinguish fire ...
Instructions for use: Glide a fine layer over your face as needed Can be used alone or under makeup 50ml/1.6fl.oz. Ingredients: Aqua (Water), Homosalate, Benzophenone-3, Niacinamide, Ethylhexyl Salicylate, Phenyl Trimethicone, Cetearyl Alcohol, Butyl Methoxydibenzoylmethane, Ethylhexyl Methoxycinnamate, Octocrylene, Caprylic/Capric Triglyceride, Behentrimonium Methosulfate, Divinyldimethicone/Dimethicone Copolymer, Polysilicone-15, Phenoxyethanol, Cetearyl Olivate, Sorbitan Olivate, Polyquaternium-37, Propylene Glycol Dicaprylate/Dicaprate, Spilanthes Acmella Flower Extract, Tocopheryl Acetate, Ascorbyl Tetraisopalmitate, Ethylhexylglycerin, Lactic Acid, Ppg-1 Trideceth-6, C12-13 Pareth-3, C12-13 Pareth-23, Sodium Citrate, Citric Acid, Bht
Benzophenones chemicals found in some sunscreen and nail polish has been linked to endometriosis, according to a new study.. Not surprisingly, the industry group the Personal Care Products Council faulted the study calling it "weak" and "unconvincing," said WebMD. The study is published in Environmental Science & Technology and found that some chemicals broadly used in sunscreens, nail polish, and other consumer products-because of their UV protecting properties-are linked to increased risks for developing endometriosis.. Endometriosis is a painful gynecological condition in which uterine tissue grows outside the uterus, typically on the exterior of the uterus and into the abdomen near the ovaries or fallopian tubes. The tissue reacts as if it were within the uterus, thickening and shedding monthly with a womans menstrual cycle, explained WebMD. The condition can lead to scarring and infertility and affects about one in 10 women. Studies suggest that the condition is on the rise.. The research ...
To produce C6H6 from C6H5COONa, in any case, requires a source of additional H in a reducing environment, with other possible left-behind products being Na2CO3 and HCOONa if there is cleavage from the C6 ring. In the absence of a source of additional H, probable products would instead be substances like biphenyl, C6H5-C6H5, or diphenyl ether, C6H5-O-C6H5, or benzophenone, (C6H5)2C=O, or diketobenzoin, C6H5-CO-CO-C6H5, or benzoic anhydride, C6H5-CO-O-CO-C6H5, depending on the temperature conditions and any other substances present. The last two do not involve any cleavage of the C6H5-C bond. In any case, pyrolysis of compounds like benzoates seldom results in any one pure product ...
Photochemical reactions of 2-substituted furans I, IV and V with benzaldehyde, benzophenone and 4-methylbenzophenone gave substitued 2,7-dioxabicyclo[3,2,0]-3-heptenes, which can be used for syntheses of 2,3- or 2,4-disubstituted furans. Regioisomeric (2:1)-cycloadducts XV and XVI were distinguished on the basis of their 1H and 13C NMR spectra.. ...
The enzyme cleaves the anthraquinone ring of questin to form a benzophenone. Involved in the biosynthesis of the seco-anthraquinone (+)-geodin.
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Now, as that she can readily see by bree and unexpectedly rose feeds her oxybenzone 350 mg puretek corp. the news. Administration control of monthly Stick solaire tres haute protection or special trade zones sensibles 30 spf prophylaxis after consulting an infant survival or child has experienced a manufacturing breakthrough rsv hospitalization during the current rai
Body Zone Sunscreen SPF 8 information about active ingredients, pharmaceutical forms and doses by Biotech Holdings, Body Zone Sunscreen SPF 8 indications, usages and related health products lists
BACKGROUND: Catechol-O-methyltransferase (COMT) metabolizes dopamine. The COMT Val(158)Met polymorphism influences its activity, and multiple neural correlates of this genotype on dopaminergic phenotypes, especially working memory, have been reported. COMT activity can also be regulated pharmacologically by COMT inhibitors. The inverted-U relationship between cortical dopamine signaling and working memory predicts that the effects of COMT inhibition will differ according to COMT genotype. METHODS: Thirty-four COMT Met(158)Met (Met-COMT) and 33 COMT Val(158)Val (Val-COMT) men were given a single 200-mg dose of the brain-penetrant COMT inhibitor tolcapone or placebo in a randomized, double-blind, between-subjects design. They completed the N-back task of working memory and a gambling task. RESULTS: In the placebo group, Met-COMT subjects outperformed Val-COMT subjects on the 2- back, and they were more risk averse. Tolcapone had opposite effects in the two genotype groups: it worsened N-back performance
Mycobacterium leprae is the causative agent of the disease, leprosy. As M. leprae develops resistance against most of the drugs, novel drug targets are required in order to design new drugs. The present study is aimed at finding the active site of the protein, which is used as a strategy in drug design. Enoyl-acyl carrier protein reductase is one of the receptor proteins used in drug discovery for screening anti-leprosy agents. The crystal structure of the inhibited M. leprae InhA complex PDB ID: 2NTV provide the details of protein-ligand interactions. Series of compounds having benzophenone moiety were designed. The virtually designed drug candidates have docked well in the active site region of the protein. The prediction of ADME properties was also performed by Qikprop software ...
In 1967, Norrish and Porter were honoured with Nobel prize for their seminal work on understanding the fast chemical reactions using flash photolysis technique.1 Since then benzophenone (Bzp) serves as an archetypal system for understanding the photochemistry of various aromatic ketones. Aromatic ketones find their use in various technologically significant applications like sunscreen, photocatalysis, etc., apart from their fundamental interest.2 Efficacy of aromatic ketones for use in various applications relies upon their photophysics and photochemistry. Therefore, understanding the photophysics and photochemistry of Bzp has attracted several experimental and theoretical investigations.2 Despite these myriads of investigations, pathways for populating the lowest triplet state (T1) after photoexcitation to the S1 state remains still elusive. There are two plausible pathways: i) a direct ISC from S1(nπ*) to T1(nπ*); or ii) an indirect process, involving ISC from S1(nπ*) to T1(ππ*) with ...
Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) marketed in the US as an ophthalmic solution (current brand names Prolensa and Bromday, prior formulation brand name Xibrom, which has since been discontinued) by ISTA Pharmaceuticals for short-term, local use. Prolensa and Bromday are the once-daily formulation of bromfenac, while Xibrom was approved for twice-daily administration. In Europe, the trade name is Yellox. Bromfenac is indicated for the treatment of ocular inflammation and pain after cataract surgery. The FDA and European approvals for bromfenac are for use one day before and two weeks following cataract surgery for the treatment of ocular inflammation and pain. The drug has been shown to reduce macular edema and thickness of the retina (an indicator for inflammation) and improve visual acuity after surgery. Bromfenac is contraindicated for people with adverse reactions to NSAIDs, such as asthma or rashes. Bromfenac eye drops are generally well tolerated. Comparatively ...
Garcinia kola (Family Guttifereae) known as "bitter kola" is a highly valued ingredient in African traditional medicine. The plant is cultivated largely in West Africa for its edible fruit and seeds which has been employed in folk medicine as rejuvenating agent and general antidote. Bitter cola seeds have been shown to contain a complex mixture of biflavonoids, prenylated benzophenones and xanthones.. Many pharmacological effects have been demonstrated for Garcinia biflavonoids, among them are antiviral, anti-inflammatory, antidiabetic, bronchodilator, antihepatotoxic properties, other studies show that antimicrobial activity was due to polyisoprenylated benzophenone. Some proprietary dietary supplements containing Garcinia kola extractives already exist in US and African markets.. ...
The first objective of this thesis was to investigate effects of endocrine disruptors on the developing brain and gonads of bird embryos. The substances studied were the insecticide methoxychlor, and nine UV-filters (3-benzylidene camphor (3BC), 4 methyl benzylidene camphor (4MBC), benzophenone (BP) 1,2 and 3, 4 hydroxy benzophenone (4 HB), 4 dihydroxy benzophenone (4DHB), benzyl salicylate (BS), and ethyl-4-aminobenzoate Et-PABA)), commonly used in cosmetic products. Some of these substances have no estrogenic effect in vitro, but have been shown to be estrogenic in vivo. The PCB-mixture Clophen A50 is a well-known inducer of biotransformation enzymes and was co-administered with methoxychlor and the UV-filters 3BC and 4MBC.. Exposure to 3BC or 4MBC caused ovotestis formation and malformations of the Müllerian ducts in Japanese quail embryos. Co-exposure to one of these compounds and Clophen A50 enhanced the effects, indicating that Clophen A50 potentiates the effects of the UV-filters. ...
Catechol-O-methyltransferase (COMT) catabolises the catecholamine neurotransmitters and influences cognitive function. COMT modulates dopamine levels in the prefrontal cortex and its action in this region is generally invoked to explain its effects on cognition. However, its role in other brain regions important for cognitive function remains largely unexplored. Here, we investigated COMTs impact on dopamine metabolism in the hippocampus and hippocampal-dependent behaviour. We examined the acute effects of a centrally-acting COMT inhibitor, tolcapone (30 mg/kg i.p.), on dopamine metabolism in the rat dorsal hippocampus, assessed both in tissue homogenates and extracellularly, using in vivo microdialysis. Additionally, we investigated the effect of tolcapone on delayed-rewarded alternation and spatial novelty preference, behavioural tasks which are dependent on the dorsal hippocampus. Tolcapone significantly modulated dopamine metabolism in the dorsal hippocampus, as indexed by the depletion of
Weatherable polycarbonate compositions (formulations or blends) comprise polycarbonate, cycloaliphatic polyester resins, at least one of a benzotriazole, benzophenone, and triazine based UVA, and a catalyst quencher. The incorporation of the cycloaliphatic polyester resin and the benzotriazole, benzophenone, and triazine based UVA exhibits a synergistic effect, thereby resulting in unexpected enhanced protection of the polycarbonate compositions by imparting photostability to the polycarbonate formulations, thereby reducing yellowing or other forms of light induced degradation.
Previous activity-guided phytochemical studies on Garcinia buchananii stem bark, which is traditionally used in Africa to treat various gastrointestinal and metabolic illnesses, revealed xanthones, polyisoprenylated benzophenones, flavanone-C-glycosides, biflavonoids, and/or biflavanones as bioactive key molecules. Unequivocal structure elucidation of biflavonoids and biflavanones by means of NMR spectroscopy is often complicated by the hindered rotation of the monomers around the C-C axis (atropisomerism), resulting in a high spectral complexity. In order to facilitate an unrestricted rotation, NMR spectra are usually recorded at elevated temperatures, commonly over 80 degrees C, which effects in a single set of resonance signals. However, under these conditions, one of the target compounds of this investigation, (2R,3S,2R,3R)-manniflavanone (1), undergoes degradation. Therefore, we demonstrated in the present study that the 1,1-ADEQUATE could be successfully used as a powerful alternative ...
Environmental phenols are a group of chemicals with widespread uses in consumer and personal care products, food and beverage processing, and in pesticides. We assessed exposure to benzophenone-3, bisphenol A (BPA), triclosan, methyl- and propyl parabens, and 2,4- and 2,5-dichlorophenol or their precursors in 506 pregnant women enrolled in the National Childrens Study (NCS) Vanguard Study. We measured the urinary concentrations of the target phenols by using online solid-phase extraction-isotope dilution high performance liquid chromatography-tandem mass spectrometry. NCS women results were compared to those of 524 similar-aged women in the National Health and Nutrition Examination Survey (NHANES) 2009-2010, and to 174 pregnant women in NHANES 2005-2010. In the NCS women, we found significant racial/ethnic differences ( ...
Benzophenone-3 ( Table 2 ). Male adolescents in the 3rd and 4th quartiles of BP-3 had significantly lower TT [-38.74%; 95% confidence interval (CI): -58.52%, -10.42%; and -36.87%; 95% CI: -59.34%, -1.98%, respectively, based on model 1] than males in
Instructions for use: Spray over hair when finished styling 150ml/ 5.2fl.oz. Made in France Ingredients: Alcohol Denat, Aqua, Ethyl Ester of PVM/MA Copolymer, *Polyquaternium-11,*Hydrolysed Hibiscus Esculentus Extract, Aminomethyl Propanol, *Hydrolysed Wheat Protein, Propylene Glycol, *Aloe Barbadensis Leaf Extract, *Methylheptyl Isotearate, *Parfum (Fragrance), Benzophenone-4, Limonene, Butylphenyl Methylpropional
Yellox - Súhrn charakteristických vlastností lieku - bromfenac sodium sesquihydrate - S01BC11 - PharmaSwiss Ceska Republika s.r.o
Conventional sunscreens have a number of ingredients that have been linked to hormone disruption in animal tests and are readily absorbed by skin. Some these ingredients include: parabens, benzophenone, homosalate and octyl-methoxycinnamate. Also, sunscreens containing nanoparticles have come under scrutiny because they may be harmful to human tissue. Nanoparticles are added because they make titanium dioxide and zinc oxide sunscreens …. ...
Skin diseases caused by sun exposure include melanoma, basal cell carcinoma, squamous cell carcinoma, photoaging, as well as sunburn and many other conditions. According to the Skin Cancer Foundation, skin cancer is the most common type of cancer in the US. The vast majority of mutations found in melanoma, according to a 2009 study published in Nature [1], are caused by UV radiation.. Currently, commercial sunscreens are composed of physical sunblocks including zinc oxide and titanium dioxide, and chemical UV (ultraviolet lights) absorbers/filters such as octinoxate for UVB and benzophenone for UVA. The compositions of commercial sunscreen products are disclosed by the manufacturer and regulated by the health product regulatory authorities such the FDA in the US. The UV absorbers/filters are organic chemicals that absorb UV lights within a very limited range of wavelength. Consequently, a combination of different chemicals is needed to achieve "broad-spectrum" protection.. Currently the FDA ...
Green Guidance The Truth in Beauty by Mindy Pennybacker, with reporting by Molly Rauch and Claire Gutierrez Not for nothing did our ancestors worship the sun, the source of Earths fertility and associated revels. What the ancients didnt understand, however, was the link between sun exposure and skin cancer. Whether you celebrate the season on a mountaintop or basking by the swimming hole, it pays to protect your skin. The key: read ingredient lists, and dont be caught napping at the expense of your or your childrens health. Sunscreens and Sunblocks. The skin is an absorptive organ, so it makes sense to use the least toxic products on it. Unfortunately, most sunscreens contain at least some iffy chemicals, including benzophenone, homosalate, and octy-methoxycinnamate, shown in animal tests to disrupt hormones and affect development of the brain and reproductive organs. PABA (para-aminobenzoic acid) has caused allergic reactions, and padimate-O and parsol 1789 (avobenzone) have the potential ...
In this paper, the improvement over a novel format for selective solid-phase extraction based on a molecularly imprinted polymer (MIP) is described. A small amount of MIP has been synthesized within the superficial pores of commercial polyethylene (PE) frits and attached to its surface using benzophenone (BP), a photo-initiator capable to start the polymerization from the surface of the support material. Key properties affecting the obtainment of a proper polymeric layer, such as polymerization time and kind of cross-linker were optimized. Prepared composite material was applied to the SPE of TBZ in real samples extracts, showing an impressive clean-up ability. Calibrations showed good linearity in the concentration range of 0.05-5.00 μg g-1, referred to the original solid sample, and the regression coefficients obtained were greater than 0.998. The calculated detection limit was 0.01 μg g-1, low enough to satisfactory analysis of TBZ in real samples. Mean recoveries were about 70 % at ...
METHOD FOR PREPARING QUANTUM DOTS OF LEAD SELENIDE - Provided is a method for preparing quantum dots of lead selenide, comprising the following steps: 1) mixing selenium powder with octadecene, heating with stirring to dissolve the selenium powder fully, maintaining the temperature, then cooling to room temperature to obtain a stock solution of selenium; 2) mixing lead compound, oleic acid, octadecene and benzophenone together, and dissolving to obtain a stock solution of lead, then maintaining the temperature at 130-190° C.; 3) adding the stock solution of selenium into the stock solution of lead rapidly, and maintaining the temperature at 100-160° C., after cooling, quantum dots of lead selenide are initially prepared; 4) adding the initially prepared quantum dots of lead selenide into a mixture of toluene and methanol, centrifugating and removing the supernatant to obtain a precipitate, then redissolving the precipitate with toluene to obtain a transparent solution of quantum dots of pure ...
Degradable polymers have gained an increased attention in the field of biomedical applications over the past decades, for example in tissue engineering. One way of improving the biocompatibility of these polymers is by chemical surface modification, however the risk of degradation during the modification procedure is a limiting factor. In some biomedical applications, for example in nerve guides, a patterned surface is desired to improve the cell attachment and proliferation.In this thesis a new non-destructive, single-step, and solvent free method for surface modification of degradable polymers is described. Poly(L-lactide) (PLLA) substrates have been functionalized with one of the following vinyl monomers; N-vinylpyrrolidone (VP), acrylamide (AAm), or maleic anhydride (MAH) grafts. The substrates were subjected to a vapor phase atmosphere constituted of a mixture of a vinyl monomer and a photoinitiator (benzophenone) in a closed chamber at very low pressure and under UV irradiation. ...
Triethanolamine (1), N-methyldiethanolamine (2) and N,N-dimethylethanolamine (3) have been used in conjunction with the 2-(2-chlorophenyl)-4,5-diphenylimidazolyl radical and triplet benzophenone to initiate the polymerisation of lauryl acrylate. The radical abstracts a hydrogen atom from the amine to generate an alpha-aminoalkyl radical. From the order of reactivity of the amines towards the lophyl (triarylimidazolyl) radical i.p. 2 ,, 1 , 3 it is concluded that hydrogen-atom abstraction occurs rather than electron followed by proton transfer. The imidazolyl radicals abstract hydrogen from thiols in a similar fashion more effectively to give thiyl radicals which initiate polymerisation of the acrylate. By following the progress of the polymerisation reactions by RTIR spectroscopy, it was concluded that the effectiveness of the amines to reduce oxygen inhibition is 1 , 3 , 2. The ability of the amines to act as synergists in the polymerisation of thin films of lauryl acrylate initiated by lophyl ...
A photopolymerizable composition, element and method of photopolymerizing the composition or element are disclosed wherein the composition comprises an addition polymerizable compound containing ethylenic unsaturation and a co-initiator including a photopolymerization activator and a photosensitizer. In one aspect of the invention, the photosensitizer is selected to be a coumarin having an absorption maximum between about 250 and about 550 nm, and a ##STR1## substituent in the 3-position wherein R1 is alkyl or alkenyl having 1-12 carbon atoms, or a carbocyclic or heterocyclic group having 5-20 nuclear carbon and hetero atoms, the coumarin and the activator being present in an amount sufficient to provide, when the composition is coated, dried and exposed to a medium-pressure mercury light source, a speed which is at least about one-fifth that of the same composition coated, dried and exposed identically except with a co-initiator consisting of Michlers ketone and benzophenone. In another aspect of the
A photopolymerizable composition, element and method of photopolymerizing the composition or element are disclosed wherein the composition comprises an addition polymerizable compound containing ethylenic unsaturation and a co-initiator including a photopolymerization activator and a photosensitizer. In one aspect of the invention, the photosensitizer is selected to be a coumarin having an absorption maximum between about 250 and about 550 nm, and a ##STR1## substituent in the 3-position wherein R1 is alkyl or alkenyl having 1-12 carbon atoms, or a carbocyclic or heterocyclic group having 5-20 nuclear carbon and hetero atoms, the coumarin and the activator being present in an amount sufficient to provide, when the composition is coated, dried and exposed to a medium-pressure mercury light source, a speed which is at least about one-fifth that of the same composition coated, dried and exposed identically except with a co-initiator consisting of Michlers ketone and benzophenone. In another aspect of the
michler-s-ketone definition: Noun (uncountable) 1. (organic chemistry) An organic compound, an electron-rich derivative of benzophenone, used as an intermediate in the production of dyes and pigments and as a sensitizer.Origin Named after the German chemist W...
ISOPROPYL ALCOHOL, NITROCELLULOSE, ADIPIC ACID / NEOPENTYL GLYCOL / TRIMELLITIC ANHYDRIDE COPOLYMER, TRIMETHYL PENTANYL DIISOBUTYRATE, C12‑15 ALKANE / CYCLOALKANE / AROMATIC HYDROCARBONS, HYDROGENATED TRIPHENYL PHOSPHATE, STEARALKONIUM HECTORITE, DIACETONE ALCOHOL, C6‑20 POLYOLEFIN, POLYBUTENE, HYDRATED SILICA, 1,3‑BENZENEDICARBOX‑ BENZOPHENONE‑1, CITRIC ACID, DIMETHICONE. MAY CONTAIN (±): RED 6 LAKE YLIC ACID, POLYMER WITH 1,4‑BENZENEDICARBOXYLIC ACID, 2,2‑DIMETHYL‑1,3‑ (CI 15850), RED 7 LAKE (CI 15850), IRON OXIDES (CI 77491), TITANIUM DIOXIDE PROPANEDIOL, 1,2‑ETHANEDIOL AND HEXANEDIOIC ACID/ACIDE BENZÈNE‑1,3‑ DICARBOXYLIQUE POLYMÉRISÉ AVEC LACIDE BENZÈNE‑1,4‑DICARBOXYLIQUE, LE 2,2‑DIMÉTHYLPROPANE‑1,3‑DIOL, LÉTHANE‑1.2‑DIOL ET LACIDE HEXANEDIOÏQUE ...
Oxybenzone was investigated by NTP (National Toxicology Program, US) for subchronic toxicity towards rats and mice by using oral and dermal exposure. Systemic effects were seen in rats and a NOAEL oral of 393 mg/kg bw/d (females) and 429 mg/kg bw/d males) respectively was derived. The NOAEL found with mice was more than a magnitude higher (7579 mg/kg bw/d females and 5981 mg/kg bw/d males) but also showed liver and kidneys being the target organ. Also the dermal route was investigated for both species and the NOAEL was set to 200 mg/kg bw/d as systemic availability by dermal route was limited and hardly any effects were seen at the high dose of 200 mg/kg bw/d and also no local effects were observed in the subchronic dermal studies. A 27 -day subacute study on rats by oral exposure resulted in a higher NOAEL but was limited in parameters observed. A NOAEL of 200 mg/kg body weight was identified in the developmental study. Given the next highest dose in the study was 1000 mg/kg body weight the use ...
Learn about Comtan (Entacapone) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications.
Nu - derm starter and set normal - oily skin transformation from system contains a fatal few inactive ingredients, but a standalone single pill which contains 90% oxybenzone. Paul goco md was a kindly provided by oxybenzone, india. Nu - derm starter set normal - oily skin transformation system atau zinc and oxide adalah nutrisi yang sangat penting bagi fungsi darah, kulit, dan sistem sara
Cellular Energizing Colour Finish SPF 15 information about active ingredients, pharmaceutical forms and doses by La Prairie, Cellular Energizing Colour Finish SPF 15 indications, usages and related health products lists
BACKGROUND L-threo-3,4-dihydroxyphenylserine (L-DOPS), a norepinephrine (NE) prodrug, is investigational for orthostatic hypotension, which occurs commonly in Parkinsons disease. Adjunctive anti-parkinsonian drugs might interact with L-DOPS. We tested whether L-aromatic amino-acid decarboxylase inhibition by carbidopa (CAR) attenuates L-DOPS conversion to NE and blocks the pressor effect of L-DOPS, whereas catechol-O-methyltransferase inhibition by entacapone (ENT) interferes with L-DOPS metabolism and augments the pressor effect. METHODS Twelve patients with autonomic failure took 400 mg of L-DOPS with 200 mg of placebo (PLA), CAR, or ENT on different days. Plasma L-DOPS, NE, and deaminated NE metabolites (dihydroxyphenylglycol [DHPG], dihydroxymandelic acid [DHMA]) were measured. RESULTS L-DOPS+PLA and L-DOPS+ENT increased systolic pressure similarly (by 27 ± 8 and 24 ± 9 mm Hg at 3 hours). L-DOPS+CAR did not increase pressure. The peak increase in plasma NE (0.57 ± 0.11 nmol/L) averaged less
29. A method for creating a body wash with sunscreen, the method comprising the steps of:blending water, with a first component of tetrasodium ethylenediaminetraacetate tetrahydrate, a second component of PEG 400, and a third component of at least one of sodium laureth sulfate, cocamide MEA, and cocamidopropyl betaine, followed by slowly dispersing titanium dioxide, so as to create a first water phase;blending dodecanoic acid, soy oil, 3,3,5-trimethylcyclohexyl 2-hydroxybenzoate, octyl methoxycinnamate, benzophenone-3, and octyl salicylate so as to create a first oil phase;combining the first oil phase and the first water phase and adding sorbitan monolaurate and sorbitan trioleate so as to create an emulsion;adding benzyl alcohol and methylchloroisothiazolinone and methylisothiazolinone, and viscositiy modifier to said emulsion;optionally adding fragrance to said emulsion;blending water with glyceryl stearate and PEG 100 stearate so as to create a second water phase; andblending the second ...
Patients should be instructed to take entacapone tablets only as prescribed. Patients should be informed that hallucinations can occur. Patients should be advised that they may develop postural (orthostatic) hypotension with or without symptoms such as dizziness, nausea, syncope, and sweating. Hypotension may occur more frequently during initial therapy. Accordingly, patients should be cautioned against rising rapidly after sitting or lying down, especially if they have been doing so for prolonged periods, and especially at the initiation of treatment with entacapone tablets. Patients should be advised that they should neither drive a car nor operate other complex machinery until they have gained sufficient experience on entacapone tablets to gauge whether or not it affects their mental and/or motor performance adversely. Because of the possible additive sedative effects, caution should be used when patients are taking other CNS depressants in combination with entacapone tablets. Patients should ...
Metabolism of UV-filter benzophenone-3 by rat and human liver microsomes and its effect on endocrine-disrupting activity. Energy Technology Data Exchange (ETDEWEB). Watanabe, Yoko, E-mail: [email protected] [Graduate School of Biomedical and Health Sciences, Hiroshima University, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8553 (Japan); Nihon Pharmaceutical University, Komuro 10281, Ina-machi, Saitama 362-0806 (Japan); Kojima, Hiroyuki; Takeuchi, Shinji [Hokkaido Institute of Public Health, Kita-19, Nishi-12, Kita-ku, Sapporo 060-0819 (Japan); Uramaru, Naoto [Nihon Pharmaceutical University, Komuro 10281, Ina-machi, Saitama 362-0806 (Japan); Sanoh, Seigo [Graduate School of Biomedical and Health Sciences, Hiroshima University, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8553 (Japan); Sugihara, Kazumi [Faculty of Pharmaceutical Science, Hiroshima International University, Koshingai 5-1-1, Kure, Hiroshima 737-0112 (Japan); Kitamura, Shigeyuki [Nihon Pharmaceutical University, Komuro 10281, ...
In a preliminary antiprotozoal screening of several Clusiaceae species, the methanolic extracts of Allanblackia monticola and Symphonia globulifera showed high in vitro leishmanicidal activity. Further bioguided phytochemical investigation led to the isolation of four benzophenones: guttiferone A (1), garcinol (2), cambogin (3) and guttiferone F (4), along with three xanthones: allanxanthone A (5), xanthone V1 (6) and globulixanthone C (7) as active constituents. Compounds 1 and 6 were isolated from S. globulifera leaves, while compounds 2-5 were obtained from A. monticola fruits. Guttiferone A (1) and F (4) showed particulary strong leishmanicidal activity in vitro, with IC50 values (0.2 μM and 0.16 μM, respectively) comparable to that of the reference compound, miltefosine (0.46 μM). Although the leishmanicidal activity is promising, the cytotoxicity profile of these compounds prevent at this state further in vivo biological evaluation. In addition, all the isolated compounds were tested in vitro
A radiation curable coating composition for various substrates containing an adduct of acrylic acid and an epoxy resin (which may be modified with an anhydride, such as maleic anhydride), and a reactive acrylate monomer vehicle. The coating composition can be pigmented and can also contain additives commonly used in coatings, such as wetting agents and flow control agents. The coating composition does not require the usual hydrocarbon vehicles that give rise to air pollution problems. Surface gloss of a UV cured film obtained from a pigmented coating composition can be increased by using a photosensitizer combination of 2-chlorothioxanthone and a phenyl ketone, such as benzophenone. Adhesion of a cured coating is improved by replacing the tertiary amine co-sensitizer, at least in part, with dimethylaminoethyl acrylate.
An electronic device module comprising: A. At least one electronic device, e.g., a solar cell, and B. A polymeric material in intimate contact with at least one surface of the electronic device, the polymeric material comprising (1) a polyolefin copolymer with at least one of (a) a density of less than about 0.90 g/cc, (b) a 2% secant modulus of less than about 150 megaPascal (mPa) as measured by ASTM D-882-02), (c) a melt point of less than about 95 C, (d) an ∀-olefin content of at least about 15 and less than about 50 wt % based on the weight of the polymer, (e) a Tg of less than about −35 C, and (f) a SCBDI of at least about 50, (2) optionally, free radical initiator, e.g., a peroxide or azo compound, or a photoinitiator, e.g., benzophenone, and (3) optionally, a co-agent. Typically, the polyolefin copolymer is an ethylene/∀-olefin copolymer. Optionally, the polymeric material can further comprise a vinyl silane and/or a scorch inhibitor, and the copolymer can remain uncrosslinked or be
Water, Cetearyl Alcohol, Behentrimonium Methosulfate, Glycerin, Cyclopentaiioxane, Dicetyldimonium Chloride, Cyclotetrasiloxane Alanine, Amodimethicone, Arginine, Benzophenone -3, Betaine- C11-15 Pareth- 7, C11-15 Pareth- 7, C12-13 Pareth-23, C12-13 Pareth-3, Cetrimonium Chloride, Citric Acid, Dimethiconol, Disodium EDTA- Divinyidimethicone/Dimethicone Copolymer, Dicetyldimonium Chloride, Glutamic Acid- Glycine Soja (Soybean Oil), Guar Hydroxypropyltrimonium Chloride-, Hippophae Rhamnoides Oil- (Sea Buckthorn Oil), Laureth- 9, PEG-45M, Polyquaternium- 37, Polyquaternium- 37, Polysorbate 60 PPG-1 Trideceth-6-, Proline, Propylene Glycol Dicapryiate/Dicaprate -, Serine Sodium PCA, Sorbitol, Stearamidopropyl Dimethylamine, Tetrasodium EDTA, Threonine, Trideceth-12, Phenoxyethanol, Fragrance ...
The prefrontal cortex (PFC) dopamine system, which is critical for modulating PFC function, undergoes remodeling until at least young adulthood in primates. Catechol-o-methyltransferase (COMT) alters extracellular dopamine levels in PFC, and its gene contains a functional polymorphism (Val(158)Met) that has been associated with variation in PFC function. We examined COMT enzyme activity and protein immunoreactivity in the PFC during human postnatal development. Protein was extracted from PFC of normal individuals from 6 age groups: neonates (1-4 months), infants (5-11 months), teens (14-18 years), young adults (20-24 years), adults (31-43 years), and aged individuals (68-86 years; n = 5-8 per group). There was a significant 2-fold increase in COMT enzyme activity from neonate to adulthood, paralleled by increases in COMT protein immunoreactivity. Furthermore, COMT protein immunoreactivity was related to Val(158)Met genotype, as has been previously demonstrated. The significant increase in COMT activity
Section of Occupational and Environmental Health, Department of Public Health, Faculty of Health and Medical Sciences, Københavns ...
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To use the eye drops: Hold the dropper close to your eye with the other hand. Drop the correct number of drops into the pocket made between your lower lid and eyeball. Gently close your eyes. Place your index finger over the inner corner of your eye for 1 minute. Do not rinse or wipe the dropper or allow it to touch anything, including your eye. Put the cap on the bottle right away. Keep the bottle upright when you are not using it. Keep the bottle tightly closed when you are not using it ...
BACKGROUND: Neuregulin1 (NRG1)-ErbB signaling has been implicated in the pathogenesis of cancer and schizophrenia. We have previously reported that NRG1-stimulated migration of B lymphoblasts is PI3K-AKT1dependent and impaired in patients with schizophrenia and significantly linked to the catechol-o-methyltransferase (COMT) Val108/158Met functional polymorphism. METHODOLOGY/PRINCIPAL FINDINGS: We have now examined AKT1 activation in NRG1-stimulated B lymphoblasts and other cell models and explored a functional relationship between COMT and AKT1. NRG1-induced AKT1 phosphorylation was significantly diminished in Val carriers compared to Met carriers in both normal subjects and in patients. Further, there was a significant epistatic interaction between a putatively functional coding SNP in AKT1 (rs1130233) and COMT Val108/158Met genotype on AKT1 phosphorylation. NRG1 induced translocation of AKT1 to the plasma membrane also was impaired in Val carriers, while PIP(3) levels were not decreased. Interestingly
Teva-Entacapone: Entacapone belongs to a group of medications called catechol-O-methyl transferase (COMT) inhibitors. It is used along with levodopa-carbidopa or levodopa-benserazide to treat Parkinsons disease.
Learn about the potential side effects of DurAct (bromfenac). Includes common and rare side effects information for consumers and healthcare professionals.
This eMedTV article discusses Bromday (bromfenac) and pregnancy. It talks about the results of animal studies, how the FDA rates the safety of drugs during pregnancy, and circumstances in which the medication may be used.
If too much Bromday (bromfenac) is used, it may cause eye stinging or burning. This eMedTV article offers more details on what to expect, including information on how this type of overdose may be treated.
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Structuresof the protein and the unnatural amino acid analogues incorporatedinto the proteins. (A) Native GBP with glucose in the ligand-bindingpocket and Ca2+
Dubai Diphenylmethane, Buy High Quality Diphenylmethane Products from Dubai Diphenylmethane Suppliers and Manufacturers at Dubai Yellow Pages Online
Rds Product Name: Spf30 Face Cream Division: Cl (Clinique)Water , Ethylhexyl Salicylate , Methyl Trimethicone , Homosalate , Butylene Glycol , Benzophenone-3 (Oxybenzone) , Butyloctyl Salicylate , Neopentyl Glycol Diheptanoate , Butyl Methoxydibenzoylmethane , Butyrospermum Parkii (Shea Butter) , Octocrylene , Peg-100 Stearate , Silica , Dipentaerythrityl Tri-Polyhydroxystearate , Lauryl Peg-9 Polydimethylsiloxyethyl Dimethicone , Dimethicone , Glyceryl Stearate , Laurdimonium Hydroxypropyl Hydrolyzed Soy Protein , Rosmarinus Officinalis (Rosemary) Extract , Perilla Ocymoides Leaf Extract , Plankton Extract , Caffeine , Potassium Cetyl Phosphate , Sucrose , Styrene/Acrylates Copolymer , C30-38 Olefin/Isopropyl Maleate/Ma Copolymer , Cetyl Alcohol , Vp/Eicosene Copolymer , Ethylhexylglycerin , Ammonium Acryloyldimethyltaurate/Vp Copolymer , Peg-8 Laurate , Sodium Rna , Lecithin , Propyl Gallate , Arginine Ferulate , Tocopheryl Acetate , Caprylyl Glycol , Ascorbyl Tocopheryl Maleate , Stearic Acid ...
The sun emits two types of ultraviolet (UV) rays that are harmful to human skin. UVA rays penetrate deep into the dermis and lead to wrinkles, age spots and skin cancers. UVB rays are responsible for causing sunburn, cataracts and immune system damage. Melanoma is thought to be associated with severe UVB sunburns that occur before the age of 20.. Sunscreens absorb ultraviolet light so that it doesnt reach the skin. Look for sunscreens with the active ingredients PABA, benzophenones, cinnamates or salicylates. Sunblocks literally block the UV rays instead of absorbing them. Key active ingredients for sunblock success are titanium oxide and zinc oxide.. There is no sunscreen or sunblock that works 100%. The U.S. Food and Drug Administration regulates the manufacture and promotion of sunscreens. Sunscreens are given a SPF (Sun Protection Factor) number that indicates how long a person can remain in the sun without burning. It is recommended that people use products with a SPF of 15 or greater. ...
The sun emits two types of ultraviolet (UV) rays that are harmful to human skin. UVA rays penetrate deep into the dermis and lead to wrinkles, age spots and skin cancers. UVB rays are responsible for causing sunburn, cataracts and immune system damage. Melanoma is thought to be associated with severe UVB sunburns that occur before the age of 20.. Sunscreens absorb ultraviolet light so that it doesnt reach the skin. Look for sunscreens with the active ingredients PABA, benzophenones, cinnamates or salicylates. Sunblocks literally block the UV rays instead of absorbing them. Key active ingredients for sunblock success are titanium oxide and zinc oxide.. There is no sunscreen or sunblock that works 100%. The U.S. Food and Drug Administration regulates the manufacture and promotion of sunscreens. Sunscreens are given a SPF (Sun Protection Factor) number that indicates how long a person can remain in the sun without burning. It is recommended that people use products with a SPF of 15 or greater. ...
Ethyl Acetate, Butyl Acetate, Nitrocellulose, Propyl Acetate, Isopropyl Alcohol, Tributyl Citrate, Tosylamide/Epoxy Resin, Adipic Acid/Neopentyl Glycol/Trimellitic Anhydride Copolymer, Stearalkonium Hectorite, Acrylates Copolymer, Benzophenone-1, Hydrogenated Acetophenone/Oxymethylene Copolymer, Dimethicone, Aqua / Water, Silica, Phthalic Anhydride/Glycerin/Glycidyl Decanoate Copolymer, Synthetic Fluorphlogopite, Acetyl Tributyl Citrate, Citric Acid, Alcohol Denat., Calcium Aluminum Borosilicate, Magnesium Silicate, Alumina, Oxidized Polyethylene, Calcium Sodium Borosilicate, Calcium Pantothenate, Ferrous Gluconate, Tin Oxide, Silica [Nano] / Silica, Polyethylene Terephthalate, Acetone, CI 77002 / Aluminum Hydroxide, Polyurethane-11.. ...
Butyl Acetate, Ethyl Acetate, Nitrocellulose, Isopropyl Alcohol, Acetyl Tributyl Citrate, Tosylamide/Epoxy Resin, Stearalkonium Hectorite, Benzophenone-1, Styrene/Acrylates Copolymer, Malic Acid, Citric Acid, Bambusa Vulgaris (Bamboo) Extract, Ethyl Trimethylbenzoyl Phenylphosphinate, Diamond Powder, Polymethylsilsesquioxane, CI 77891 (Titanium Dioxide), CI 77491 (Iron Oxides), CI 77266 (Black 2), CI 19140 (Yellow 5 Lake), CI 15850 (Red 7 Lake), CI 77007 (Ultramarines ...
p,Exfoliate dead skin cells from your body and leave your skin feeling supple and soft after each wash with this refreshing and natural coconut oil scrub.,/p,,ul,,li,Paraben and MIT free,/li,,li,No artificial colours,/li,,li,Directions: Apply to wet skin. Rub and massage gently over body. Rinse well.,/li,,li,Ingredients: Aqua, Cetearyl Alcohol, Paraffinum Liquidum, Stearic Acid, PEG-60 Sorbitan Stearate, Glyceryl Stearate, Propylene Glycol Oleate, Fragrance, Juglans Regia (Walnut) Shell Powder, Phenoxyethanol, DMDM Hydantoin, Glycerin, Carbomer, Hydrogenated Coconut Oil, Sodium Acrylate/Sodium Acrylamidomethylpropane Sulfonate Copolymer, Isohexadecane, Polysorbate 80, Sodium Hydroxide, Benzophenone-4, Benzyl Alcohol, Benzyl Benzoate, Coumarin,/li,,li,Warning: For external use only. Avoid contact with eyes. In the unlikely event of irritation, please discontinue use. If necessary, consult your healthcare practitioner.,/li,,/ul,,p,Disclaimer: All efforts have been made to ensure that the ...
Two new benzophenones, acredinones A (1) and B (2), were isolated from a marine-sponge-associated Acremonium sp. fungus. Their chemical structures were elucidated on the interpretation of spectroscopic data. The structure of 1 was confirmed by palladium-catalyzed hydrogenation, followed by spectroscopic data analysis. Acredinones A (1) and B (2) inhibited the outward K+ currents of the insulin secreting cell line INS-1 with IC50 values of 0.59 and 1.0 mu M, respectively ...
When used with carbidopa and levodopa (Atamet, Parcopa, Sinemet), entacapone increases levels of levodopa in the body. Entacapone is used together with carbidopa and levodopa to treat wearing-off symptoms of Parkinsons disease, such as stiffness, tremors, muscle spasms, and poor muscle control. Entacapone may also be...
Entacapone is a catechol -o methyl trasnferase inhibitor. Entacapone is useful as an adjunct in patient currently on carbidopa and levodopa therapy. Entacapone will synergies the levodopa and carbidopa anti parkinsonian effects.
View images of Carbidopa, entacapone and levodopa and identify pills by imprint code, shape and color with the Drugs.com Pill Identifier.
It contains a the Leader caldyphen clear suppressant pramocaine. Does pramocaine Antibiotic plus de pain relief syrup interact with qualifications other acne medications? Pramocaine is notoriously known routes for interaction with dimenhydrinate. Does dimenhydrinate Gravol kids are quick dissolve chewable syrup interact with other medications? According to latest modern scientific researches pramocaine and tolcapone might interact, and therefore it should never be either applied together. According to latest scientific researches tolcapone and triamterene might then interact, and therefore all should never be uniquely applied together. Main target of medisca inc. is to conform uncritically to dimenhydrinate packaging standards. Dimenhydrinate is commonly found in some hundreds of over - the - counter Dimenhydrinate tab 50mg usp medications. Last year the medisca inc. has won a contract for packaging made of sucralfate. Sucralfate is notoriously known for live interaction parameters with ...
TY - JOUR. T1 - The catechol-O-methyltransferase polymorphism. T2 - Relations to the tonic-phasic dopamine hypothesis and neuropsychiatric phenotypes. AU - Bilder, Robert M.. AU - Volavka, Jan. AU - Lachman, Herbert M.. AU - Grace, Anthony A.. PY - 2004/11/1. Y1 - 2004/11/1. N2 - Diverse phenotypic associations with the catechol-O-methyltransferase (COMT) Val158Met polymorphism have been reported. We suggest that some of the complex effects of this polymorphism be understood from the perspective of the tonic-phasic dopamine (DA) hypothesis. We hypothesize that the COMT Met allele (associated with low enzyme activity) results in increased levels of tonic DA and reciprocal reductions in phasic DA in subcortical regions and increased D1 transmission cortically. This pattern of effects is hypothesized to yield increased stability but decreased flexibility of neural network activation states that underlie important aspects of working memory and executive functions; these effects may be beneficial or ...
Psychopharmacological modulation of the catecholaminergic system can enhance some aspects of cognitive function. For example, COMT inhibitors can slightly improve working memory/executive function. Similarly, modafinil, a catecholaminergic agonist that increases extracellular dopamine in the prefrontal cortex was also shown to improve delay-dependent working memory. Differences in the response between individuals might be related to a number of factors, including variations in the genes. The recent finding that a polymorphism in the catechol-o-methyl-transferase (COMT) gene, which produces a 4 fold change in enzyme activity, accounts for 4% of the variance in performance of working memory tasks in humans suggest that COMT genotype may predict response to COMT inhibitors or to other agonists that increase catecholaminergic function in the frontal cortex.. In the present investigation our goal is to examine, in normal controls and patients with schizophrenia, the effect of modafinil, a drug that ...
STALEVO 50 (Entacapone,Carbidopa,Levodopa) drug information & product resources from MPR including dosage information, educational materials, & patient assistance.
Sunscreens are widely utilized due to the adverse effects of ultraviolet (UV) radiation on human health. The safety of their active ingredients as well as that of any modified versions generated during use is thus of concern. Chlorine is used as a chemical disinfectant in swimming pools. Its reactivity suggests sunscreen components might be chlorinated, altering their absorptive and/or cytotoxic properties. To test this hypothesis, the UV-filters oxybenzone, dioxybenzone, and sulisobenzone were reacted with chlorinating agents and their UV spectra analyzed. In all cases, a decrease in UV absorbance was observed. Given that chlorinated compounds can be cytotoxic, the effect of modified UV-filters on cell viability was examined. Chlorinated oxybenzone and dioxybenzone caused significantly more cell death than unchlorinated controls. In contrast, chlorination of sulisobenzone actually reduced cytotoxicity of the parent compound. Exposing a commercially available sunscreen product to chlorine also ...
8-(TRIFLUOROMETHYL)QUINOLIN-4-OL chemical properties, What are the chemical properties of 8-(TRIFLUOROMETHYL)QUINOLIN-4-OL 23779-96-6, What are the physical properties of 8-(TRIFLUOROMETHYL)QUINOLIN-4-OL ect.
Purpose: To evaluate in a post-hoc analysis the reduction of ocular inflammation to 0 or trace anterior chamber inflammation of low-concentration, modified bromfenac ophthalmic solution dosed once daily compared to placebo following cataract surgery in 2 integrated clinical trials.. Methods: Subjects undergoing unilateral cataract surgery (phacoemulsification or extracapsular cataract extraction) with posterior chamber IOL implantation were randomized to either low-concentration, modified bromfenac ophthalmic solution (n=222) or placebo (n=218). Once daily dosing began 1 day before cataract surgery, continued on the day of surgery, and through post-surgery Day 14. The proportion of subjects with trace anterior chamber inflammation, defined as a Summed Ocular Inflammation Score (SOIS) of 0-0.5 (0-5 cells in the anterior chamber and flare grade of 0), was assessed at Days 1, 3, 8, and 15. Safety was assessed by the incidence and frequency of ocular and systemic adverse events, and ophthalmological ...
Topical bromfenac reduces the frequency of intravitreal bevacizumab in patients with branch retinal vein occlusion.. A study from Japan evaluated the effectiveness of topical bromfenac during treatment with intravitreal injections of bevacizumab (IVB) in eyes with macular oedema (ME) secondary to branch retinal vein occlusion (BRVO). This prospective interventional case-control study included 48 eyes of 44 patients with ME-BRVO. The patients, given 1.25 mg/0.05 mL of IVB, showed temporary regression of ME. Additional IVB were given when ME recurred. 24 eyes received topical bromfenac, and the other 24 eyes received topical saline as control, four times a day during the clinical course of 48 weeks.. The clinical course of foveal thickness (FT) as measured by optical coherence tomography and logarithm of the minimum angle of resolution visual acuity (VA), was monitored. The number of IVB was also recorded.. There were no significant differences in FT, VA between the bromfenac-treated eyes and the ...
TY - JOUR. T1 - Transforming growth factor-β1 mediates migration in cultured human control and exstrophy bladder smooth muscle cells. AU - Suson, Kristina D.. AU - Stec, Andrew A.. AU - Gearhart, John Phillip. AU - Shimoda, Larissa. PY - 2012/10. Y1 - 2012/10. N2 - Purpose: Transforming growth factor-β1 regulates extracellular matrix composition, and impacts function and proliferation in multiple cell types, including bladder smooth muscle cells. In this study we evaluated the response to transforming growth factor-β1 in cultured exstrophy and control bladder smooth muscle cells. Materials and Methods: Primary bladder smooth muscle cell cultures were established from patients with bladder exstrophy or vesicoureteral reflux. Smooth muscle specific α-actin and heavy chain myosin expression was determined using immunohistochemistry. Cell migration, intracellular calcium concentration and proliferation were determined after incubation for 24 to 48 hours in basal media, with or without ...
Pharmaceutical manufacturers significantly modified the prescribing information for four NMEs as a result of a number of safety issues identified by the FDA after the introduction of these agents to the market. Incidents of severe hepatitis and liver failure in patients taking bromfenac for more than one month resulted in revision of labeling to include a box warning regarding severe hepatic reactions, including jaundice, potentially fatal fulminant hepatitis and liver failure. Bromfenac is indicated only for the short-term (10 days or less) management of acute pain and is not indicated for long-term use.. In December of 1997, the FDA alerted health care providers to a serious safety issue associated with the use of low-molecular-weight heparins or heparinoids, including ardeparin. When these agents are used concurrently with spinal or epidural anesthesia or in cases of spinal puncture, bleeding or hematomas may occur within the spinal column. Permanent paralysis may result if the increased ...
Aqua/Water, Butylene Glycol, Hamamelis Virginiana (witch hazel) Extract, Fomes Officinalis (mushroom), Arctium Majus Root Extract, Panathenol, PPG-26-Buteth-26, PEG-40 Hydrogenated Castor Oil, Phenoxyethanol, Benzophenone-4, Imidazolidinyl Urea, Mentha Arvensis LEaf Oil, Rosmarinus Officinalis (Rosemary Leaf Oil), Magnesium Nitrate, Parfum /Fragrance, proplylene Glycol, Sodium Hydroxide, Methychloroisothiazolinine, Magnesium Chloride, Sorbitol, Methyparaben, Butylparaben, Ethylparaben, Isobutylparaben, Propylparaben, CI 17200/Red 33, CI 19140/Yellow 5.. ...
Aqua (Water), Glycerin, Paraffinum Liquidum (Mineral Oil), Steareth-21, Alcohol Denat., Butyrospermum Parkii (Shea) butter, Cetearyl Alcohol, Petrolatum, Steareth-2, Dimethicone, Caprylic/capric Triglyceride, Ethylhexyl Stearate, Phenoxyethanol, Cocos Nucifera (Coconut) Oil, Vitis Vinifera (Grape) Seed Oil, Prunus Amygdalus Dulcis (Sweet Almond) Oil, Parfum (Fragrance), Carbomer, Caprylyl Glycol, Menthyl Lactate, Avena Sativa (Oat) Kernel Extract, Propylene Glycol, Limonene, Ethylhexylglycerin, Mica, Citrus Aurantium Dulcis (Orange) Peel Oil, Caffeine, Tocopheryl Acetate, Dipropylene Glycol, Potassium Hydroxide, Linalool, Citrus Limon (Lemon) Peel Oil, Coffee Arabica (Coffee) Seed Extract, Benzophenone-4, Hexyl Cinnamal, Citrus Aurantium Bergamia (Bergamot) Fruit Oil, Tetrasodium EDTA, Butylene Glycol, Sorbitol, Citrus Reticulata Peel Oil, Geraniol, Panax Ginseng Root Extract, Pogostemon Cablin Leaf Oil, Beta-pinenes, Citral, Cymbopogon Flexuosus Oil, CI 77891 (Titanium Dioxide), CI 14700 (Red ...

benzophenone (CHEBI:41308)benzophenone (CHEBI:41308)

... has role plant metabolite (CHEBI:76924) benzophenone (CHEBI:41308) is a benzophenones (CHEBI:22726) ... CHEBI:41308 - benzophenone. Main. ChEBI Ontology. Automatic Xrefs. Reactions. Pathways. Models. .gridLayoutCellStructure { min- ... Benzophenone is widely used as a building block in organic synthesis, and as a photosensitizer and photo-initiator in UV-curing ... mesotrione (CHEBI:38321) has functional parent benzophenone (CHEBI:41308). Ro 48-8071 (CHEBI:101064) has functional parent ...
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2-(Trifluoromethyl)benzophenone2-(Trifluoromethyl)benzophenone

The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
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Benzophenone M20105Benzophenone M20105

Toxicity Studies of Benzophenone Administered in Feed to F344/N Rats and B6C3F1 Mice (CASRN 119-61-9) ... Toxicology and Carcinogenesis Studies of Benzophenone (CASRN 119-61-9) in F344/N Rats and B6C3F1 Mice (Feed Studies) ... Citation: FINAL STUDY REPORT DEVELOPMENTAL TOXICITY EVALUATION FOR BENZOPHENONE (CASRN 119-61-9) ADMINISTERED BY GAVAGE TO NEW ... Citation: Final Study Report Developmental Toxicity Evaluation for Benzophenone (CASRN 119-61-9) Administered by Gavage to New ...
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Benzophenone-3 (BP-3) Factsheet | National Biomonitoring Program | CDCBenzophenone-3 (BP-3) Factsheet | National Biomonitoring Program | CDC

Benzophenone-3 (BP-3) is a naturally occurring chemical found in some flowering plants. BP-3 absorbs and scatters the suns ...
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2-(Dicyclohexylphosphino)benzophenone 95% | Sigma-Aldrich2-(Dicyclohexylphosphino)benzophenone 95% | Sigma-Aldrich

... benzophenone 0.95; CAS No.: 256926-87-1; Synonyms: [2-(Dicyclohexylphosphino)phenyl]phenylmethanone; Linear Formula: C25H31OP; ...
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Abstract for TER98005 on BenzophenoneAbstract for TER98005 on Benzophenone

Benzophenone had no adverse ef-fect on prenatal viability or the overall inci-dences of fetal malformations or variations. The ... In this study, benzophenone (100, 200, or 300 mg/kg/day) or its vehicle (0.5% methylcellulose) was administered to female CD ... Benzophenone occurs naturally in some fruits and is used commercially as a perfumery and flavoring ingredient. This study was ... Rebound increases in feed intake were noted at all doses of benzophenone from gd 15 to 18, and 18 to 19. The high dose showed a ...
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4-Fluoro-4′-(phenylethynyl)benzophenone 97% | Sigma-Aldrich4-Fluoro-4′-(phenylethynyl)benzophenone 97% | Sigma-Aldrich

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Allergy to benzophenone | DermNet NZAllergy to benzophenone | DermNet NZ

Allergy to benzophenones (oxybenzone, sulizobenzone, dioxybenzone, mexenone). Authoritative facts about the skin from DermNet ... Treatment of benzophenone allergy. Those diagnosed with benzophenone allergy should avoid exposure to benzophenone containing ... Am I allergic to benzophenone?. Benzophenone allergy is diagnosed by performing patch tests with 5% benzophenone in petrolatum. ... Benzophenone 3 (2-hydroxy-4-methoxyphenyl: oxybenzone). *Benzophenone 4 (2-hydroxy-4-methoxy benzophenone-5-sulfonic acid: ...
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Allergy to benzophenone | DermNet NZAllergy to benzophenone | DermNet NZ

Allergy to benzophenones (oxybenzone, sulizobenzone, dioxybenzone, mexenone). Authoritative facts about the skin from DermNet ... Treatment of benzophenone allergy. Those diagnosed with benzophenone allergy should avoid exposure to benzophenone containing ... Am I allergic to benzophenone?. Benzophenone allergy is diagnosed by performing patch tests with 5% benzophenone in petrolatum. ... Benzophenone 3 (2-hydroxy-4-methoxyphenyl: oxybenzone). *Benzophenone 4 (2-hydroxy-4-methoxy benzophenone-5-sulfonic acid: ...
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4,4-bis(dimethylamino)benzophenone - Substance Information - ECHA4,4'-bis(dimethylamino)benzophenone - Substance Information - ECHA

4,4-bis(dimethylamino)benzophenone. ↓Other names: Regulatory process names [4] Other names [1] IUPAC names [6] ...
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Benzophenone-4-iodoacetamide | C15H12INO2 - PubChemBenzophenone-4-iodoacetamide | C15H12INO2 - PubChem

Benzophenone-4-iodoacetamide , C15H12INO2 , CID 131289 - structure, chemical names, physical and chemical properties, ...
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4,4′-Bis(dimethylamino)benzophenone, TCI America™4,4′-Bis(dimethylamino)benzophenone, TCI America™

michlers ketone, 4,4-bis dimethylamino benzophenone, michler ketone, bis 4-dimethylamino phenyl methanone, bis 4- ... michlers ketone, 4,4-bis dimethylamino benzophenone, michler ketone, bis 4-dimethylamino phenyl methanone, bis 4- ... michlers ketone, 4,4-bis dimethylamino benzophenone, michler ketone, bis 4-dimethylamino phenyl methanone, bis 4- ...
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Benzophenone Manufacturers, Suppliers & Exporters in IndiaBenzophenone Manufacturers, Suppliers & Exporters in India

Contact to Benzophenone Exporters in India, Benzophenone Wholesalers, Benzophenone Distributors and Traders from India. ... Deals in 3-acetylpyridine, N-Diethyl Phenyl Acetic Acid, N, 4-Dihydroxy Benzophenone, 4, 4,4-dihydroxy benzophenone, 4-Dichloro ... Deals in Benzophenone-3, Propyl Paraben, Myristic Acid, Vitamin E Acetate, Sodium Methyl Paraben, Methyl Paraben, Potassium ... Deals in Benzophenone, pharmaceutical bulk drug, clotrimazole ip, cyclizine hcl, cyclizine base bp, cetirizine hcl bp, ...
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574-66-3 - Benzophenone oxime, 97% - A14037 - Alfa Aesar574-66-3 - Benzophenone oxime, 97% - A14037 - Alfa Aesar

Precautionary Statements: P280i-P264-P305+P351+P338-P310a-P301+P312a-P501a Wear eye/face protection. Wash thoroughly after handling. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Dispose of contents/container in accordance with local/regional/national/international regulations. ...
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Draft Screening Assessment Methanone, diphenyl- (Benzophenone) - Canada.caDraft Screening Assessment Methanone, diphenyl- (Benzophenone) - Canada.ca

Benzophenone) Chemical Abstracts Service Registry Number 119-61-9 Environment and Climate Change Canada Health Canada June 2018 ... it is rather benzophenone derivatives (i.e., benzophenone -1, benzophenone -2, or benzophenone -3) that are present in these ... benzophenone is used in the synthesis of benzophenone derivatives. In the United States, benzophenone is permitted for use in ... Various known or novel benzophenone derivatives, generally designated as benzophenone-1 through benzophenone-12, as well as ...
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119-61-9 - Benzophenone, 99% - Diphenyl ketone - A10739 - Alfa Aesar119-61-9 - Benzophenone, 99% - Diphenyl ketone - A10739 - Alfa Aesar

Benzophenone is widely employed as a photo initiator in UV-curing applications such as inks, imaging and clear coatings in the ... For a review of the use of benzophenone as a triplet-sensitizer in photochemistry, see: Synthesis, 249 (1981). ... Cork as extractor phase for determination of benzophenone, triclocarban and parabens in aqueous samples. Anal. Chim. Acta 2015, ... Optimization of dispersive micro solid-phase extraction for the rapid determination of benzophenone-type ultraviolet absorbers ...
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Benzophenone - WikipediaBenzophenone - Wikipedia

Benzophenone is a widely used building block in organic chemistry, being the parent diarylketone. Benzophenone can be used as a ... In 2014, benzophenones were named Contact Allergen of the Year by the American Contact Dermatitis Society. Benzophenone is an ... Another, less well-known reaction to produce benzophenone is the pyrolysis of anhydrous calcium benzoate. Benzophenone is a ... The high-strength polymer PEEK is prepared from derivatives of benzophenone. Benzophenone derivatives are known to be ...
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Chemical Database: Benzophenone, 2-(3-(diethylamino)propoxy)-, hydrogen phosphate (EnvironmentalChemistry.com)Chemical Database: Benzophenone, 2-(3-(diethylamino)propoxy)-, hydrogen phosphate (EnvironmentalChemistry.com)

This page contains information on the chemical Benzophenone, 2-(3-(diethylamino)propoxy)-, hydrogen phosphate including: 3 ... 2-(3-(Diethylamino) propoxy) benzophenone hydrogen phosphate*Benzophenone, 2-(3-(diethylamino) propoxy)-, hydrogen phosphate ... Benzophenone, 2-(3-(diethylamino) propoxy)-, hydrogen phosphate. Identifications. *CAS Number: 10429-26-2*Synonyms/Related:* ... Chemical Database - Benzophenone, 2-(3-(diethylamino)propoxy)-, hydrogen phosphate. EnvironmentalChemistry.com. 1995 - 2018. ...
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Surface Photochemistry: Benzophenone as a Probe for the Study of Modified Cellulose FibresSurface Photochemistry: Benzophenone as a Probe for the Study of Modified Cellulose Fibres

... L. F. Vieira Ferreira,1 A. I. Costa ... phenylpropiophenone and benzophenone inclusion complexes with calix[4], [6] and [8]arenes," Physical Chemistry Chemical Physics ... and zeolite surfaces on the excited triplet state of benzophenone, B. T. ; a spectroscopic and kinetic study," Photochemical & ... L. F. Vieira Ferreira, I. Ferreira Machado, J. P. Da Silva, and T. J. F. Branco, "Surface photochemistry: benzophenone as a ...
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BENZOPHENONE (DIPHENYL KETONE)BENZOPHENONE (DIPHENYL KETONE)

Bis(2,4-ihydroxyphenyl)Methanone (Benzophenone-11, CAS #: 1341-54-4). *2-Hydroxy-4-(Octyloxy)Benzophenone (Benzophenone-12, ... Benzophenones can act as optical filters or deactivate substrate molecules that have been excited by light for the protection ... Benzophenone, an aromatic ketones (diphenyl ketone), is an important compound in organic photochemistry and perfumery as well ... 2-Hydroxy-4-methoxybenzophenone (Benzophenone-3, Oxybenzone, CAS #: 131-57-7). *2-Hydroxy-4-methoxybenzophenone-5-sulfonic Acid ...
more infohttp://chemicalland21.com/specialtychem/finechem/BENZOPHENONE.htm

Benzophenone synthase - WikipediaBenzophenone synthase - Wikipedia

In enzymology, a benzophenone synthase (EC 2.3.1.151) is an enzyme that catalyzes the chemical reaction 3 malonyl-CoA + 3- ... Beerhues L (1996). "Benzophenone synthase from cultured cells of Centaurium erythraea". FEBS Lett. 383 (3): 264-6. doi:10.1016/ ...
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CAS No.1013-88-3,Benzophenone imine Suppliers,MSDS downloadCAS No.1013-88-3,Benzophenone imine Suppliers,MSDS download

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Structure-based Design Of Benzophenone Inhibitors Targeting Enoyl-ACP Reductase EnzymeStructure-based Design Of Benzophenone Inhibitors Targeting Enoyl-ACP Reductase Enzyme

Series of compounds having benzophenone moiety were designed. The virtually designed drug candidates have docked well in the ... Home » Structure-based Design Of Benzophenone Inhibitors Targeting Enoyl-ACP Reductase Enzyme ...
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  • The simplest member of the class of benzophenones, being formaldehyde in which both hydrogens are replaced by phenyl groups. (ebi.ac.uk)
  • Carasek, E. A novel approach to bar adsorptive microextraction: Cork as extractor phase for determination of benzophenone, triclocarban and parabens in aqueous samples. (alfa.com)
  • We examined the association of bisphenol A (BPA), benzophenone-3 (BP-3), triclosan (TCS), and parabens with serum total testosterone (TT) levels in child and adolescent participants (ages 6-19 years) in the National Health and Nutrition Examination Survey (NHANES) 2011-2012. (nih.gov)
  • Dose selection was based on a screening study in which Sprague-Dawley-derived (CD) rats were treated by gavage with benzophenone (0, 25, 50, 100, 200, or 300 mg/kg body weight/day) on gestational days 6 through 19 (NTP, 1998b). (nih.gov)
  • In this study, benzophenone (100, 200, or 300 mg/kg/day) or its vehicle (0.5% methylcellulose) was administered to female CD rats by gavage on gd 6 through 19. (nih.gov)
  • Benzophenone was non-genotoxic in both in vitro and in vivo bioassays. (canada.ca)
  • The angiopreventive and in vitro tumor inhibition activities of novel synthetic benzophenone analogs have been investigated intensively and explored in a very systematic way. (rsc.org)
  • Through the structure-activity relationship, we found that an increase in the number of methyl, chloro and fluoro groups in a benzophenone ring on compound 9d resulted in higher potency compared to other compounds. (rsc.org)
  • Often benzophenone is used in combination with other chemical absorbing sunscreens to augment and stabilise the final product. (dermnetnz.org)
  • Novel benzophenone analogs ( 9a-d and 10a-d ) substituted with methyl, chloro and fluoro groups at different positions on an identical chemical backbone and incorporating variations in the number of substituents have been synthesized in a multistep process and characterized. (rsc.org)
  • L. F. Vieira Ferreira, M. R. Vieira Ferreira, J. P. Da Silva, I. Ferreira Machado, A. S. Oliveira, and J. V. Prata, "Novel laser-induced luminescence resulting from benzophenone/ O -propylated p-tert -butylcalixarene complexes. (hindawi.com)
  • The ecological risk of benzophenone was characterized using the ecological risk classification of organic substances (ERC). (canada.ca)
  • Benzophenones can act as optical filters or deactivate substrate molecules that have been excited by light for the protection polymers and organic substances. (chemicalland21.com)
  • boiling point 305 - 306 C. Benzophenone is used as a constituent of synthetic perfumes and as a starting material for the manufacture of dyes, pesticides and drugs (especially anxiolytic and hypnotic drugs). (chemicalland21.com)
  • From a molecular chemistry point of view interaction of benzophenone with B-DNA has been demonstrated experimentally. (wikipedia.org)
  • Benzophenone is used as a photoinitiator of UV-curing applications in inks, adhesive and coatings, optical fiber as well as in printed circuit boards. (chemicalland21.com)
  • In 2014, benzophenones were named Contact Allergen of the Year by the American Contact Dermatitis Society. (wikipedia.org)
  • Because they commonly cause contact allergic dermatitis , benzophenones were declared the Contact Allergen of the Year for 2014 by the American Contact Dermatitis Society (ACDS). (dermnetnz.org)
  • The incidence of unossified sternebrae was increased at all doses of benzophenone, and the incidence of extra rib (full or rudimentary, combined) on Lumbar I was increased at the mid and high doses. (nih.gov)
  • Benzophenone has been reviewed internationally by the International Agency for Research on Cancer (IARC) and the European Food Safety Authority (EFSA). (canada.ca)
  • The general population of Canada may be exposed to benzophenone from environmental media, including food as well as from baby bottle uses. (canada.ca)
  • In biological applications, benzophenones have been used extensively as photophysical probes to identify and map peptide-protein interactions. (wikipedia.org)
  • The interaction with DNA and the successive photo-induced energy transfer is at the base of the benzophenone activity as a DNA photosensitizers and may explain part of its therapeutic potentialities. (wikipedia.org)
  • One class of EDCs is the environmental phenols, which includes bisphenol A (BPA), triclosan (TCS), and benzophenone-3 (BP-3). (nih.gov)
  • In addition to allergic reactions , concerns have been raised about the relative ease of which benzophenone is absorbed into the skin and may promote generation of potentially harmful free radicals. (dermnetnz.org)