Histiocytic Disorders, Malignant
Thymelaeaceae
Photoaffinity Labels
Toxicity Tests, Chronic
Clusiaceae
The mangosteen plant family (sometimes classified as Guttiferae; also known as Hypericaceae) of the order THEALES, subclass Dilleniidae, class Magnoliopsida. It includes trees and shrubs with resinous, sticky sap, usually with broad-ended, oblong, leathery leaves with a strong, central vein, flowers with many stamens.
Psidium
Sydnones
Photosensitizing Agents
Drugs that are pharmacologically inactive but when exposed to ultraviolet radiation or sunlight are converted to their active metabolite to produce a beneficial reaction affecting the diseased tissue. These compounds can be administered topically or systemically and have been used therapeutically to treat psoriasis and various types of neoplasms.
Acridones
Carcinogenicity Tests
Tests to experimentally measure the tumor-producing/cancer cell-producing potency of an agent by administering the agent (e.g., benzanthracenes) and observing the quantity of tumors or the cell transformation developed over a given period of time. The carcinogenicity value is usually measured as milligrams of agent administered per tumor developed. Though this test differs from the DNA-repair and bacterial microsome MUTAGENICITY TESTS, researchers often attempt to correlate the finding of carcinogenicity values and mutagenicity values.
Glycosides
Any compound that contains a constituent sugar, in which the hydroxyl group attached to the first carbon is substituted by an alcoholic, phenolic, or other group. They are named specifically for the sugar contained, such as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc. Upon hydrolysis, a sugar and nonsugar component (aglycone) are formed. (From Dorland, 28th ed; From Miall's Dictionary of Chemistry, 5th ed)
Carbon-Carbon Ligases
Molecular Structure
Sunscreening Agents
Cosmetics
Substances intended to be applied to the human body for cleansing, beautifying, promoting attractiveness, or altering the appearance without affecting the body's structure or functions. Included in this definition are skin creams, lotions, perfumes, lipsticks, fingernail polishes, eye and facial makeup preparations, permanent waves, hair colors, toothpastes, and deodorants, as well as any material intended for use as a component of a cosmetic product. (U.S. Food & Drug Administration Center for Food Safety & Applied Nutrition Office of Cosmetics Fact Sheet (web page) Feb 1995)
Skin
Cosmetic Techniques
Skin Aging
Databases, Factual
Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.
Perfume
No-Observed-Adverse-Effect Level
Terminology as Topic
Safety
Iodoacetates
Accidents, Occupational
Fraud
Counterfeit Drugs
Drugs manufactured and sold with the intent to misrepresent its origin, authenticity, chemical composition, and or efficacy. Counterfeit drugs may contain inappropriate quantities of ingredients not listed on the label or package. In order to further deceive the consumer, the packaging, container, or labeling, may be inaccurate, incorrect, or fake.
Chromatography, Micellar Electrokinetic Capillary
Electrophoresis, Capillary
Food Packaging
Containers, packaging, and packaging materials for processed and raw foods and beverages. It includes packaging intended to be used for storage and also used for preparation of foods such as microwave food containers versus COOKING AND EATING UTENSILS. Packaging materials may be intended for food contact or designated non-contact, for example, shipping containers. FOOD LABELING is also available.
Pseudoephedrine
Octanes
Solid-phase microextraction and GC-ECD of benzophenones for detection of benzodiazepines in urine. (1/275)
Benzodiazepines are common drugs that cause intoxication. Benzodiazepines and their metabolites can be converted by hydrolysis in acid to the corresponding benzophenones, which are easier to be separated from matrices because of their hydrophobic properties. In this study, a new separation technique called solid-phase microextraction (SPME), which can integrate extraction, concentration, sampling and sample introduction into one single procedure, has been employed to extract the products of benzodiazepines from urine after acid hydrolysis. The extracts were determined by gas chromatography with electron-capture detection (GC-ECD). The hydrolysis conditions were optimized by a statistic orthogonal design. Factors influencing direct-immersion (DI)-SPME process were also checked and chosen experimentally. The method was evaluated with spiked human urine samples. The recoveries of nine benzodiazepines ranged from 1 to 25%, with the highest for oxazolam and the lowest for bromazepam. The calibration curves were linear from 10 to 500 ng/mL for oxazolam, haloxazolam, flunitrazepam, nimetazepam, and clonazepam and from 20 to 1000 ng/mL for the others except bromazepam. The detection limits were 2-20 ng/mL for most drugs tested. The intraday and interday coefficients of variation of the developed method were within 10 and 17%, respectively. In addition, the utility of the method was confirmed by determining two ingested benzodiazepines (flunitrazepam and oxazolam) in a volunteer's urine; urine flunitrazepam was still detectable 32 h after a therapeutic dose (1.2 mg) of the drug. Finally, the DI-SPME was compared with the conventional liquid-liquid extraction with regard to detection limits and extraction efficiency of the analytes. By DI-SPME, more amounts of analytes could be introduced into GC column than by conventional liquid-liquid extraction, and thus lower detection limits of the analytes were reached, although benzophenone recoveries by DI-SPME were rather low. (+info)Mechanism of regulation of hsp70 chaperones by DnaJ cochaperones. (2/275)
Hsp70 chaperones assist a large variety of protein folding processes within the entire lifespan of proteins. Central to these activities is the regulation of Hsp70 by DnaJ cochaperones. DnaJ stimulates Hsp70 to hydrolyze ATP, a key step that closes its substrate-binding cavity and thus allows stable binding of substrate. We show that DnaJ stimulates ATP hydrolysis by Escherichia coli Hsp70, DnaK, very efficiently to >1000-fold, but only if present at high (micromolar) concentration. In contrast, the chaperone activity of DnaK in luciferase refolding was maximal at several hundredfold lower concentration of DnaJ. However, DnaJ was capable of maximally stimulating the DnaK ATPase even at this low concentration, provided that protein substrate was present, indicating synergistic action of DnaJ and substrate. Peptide substrates were poorly effective in this synergistic action. DnaJ action required binding of protein substrates to the central hydrophobic pocket of the substrate-binding cavity of DnaK, as evidenced by the reduced ability of DnaJ to stimulate ATP hydrolysis by a DnaK mutant with defects in substrate binding. At high concentrations, DnaJ itself served as substrate for DnaK in a process considered to be unphysiological. Mutant analysis furthermore revealed that DnaJ-mediated stimulation of ATP hydrolysis requires communication between the ATPase and substrate-binding domains of DnaK. This mechanism thus allows DnaJ to tightly couple ATP hydrolysis by DnaK with substrate binding and to avoid jamming of the DnaK chaperone with peptides. It probably is conserved among Hsp70 family members and is proposed to account for their functional diversity. (+info)Comparison of the potassium channel openers, WAY-133537, ZD6169, and celikalim on isolated bladder tissue and In vivo bladder instability in rat. (3/275)
The effects of the ATP-dependent potassium channel agonists ZD6169, celikalim, and WAY-133537 on bladder contractile function were examined in vitro on isolated bladder strips and in vivo on spontaneous bladder contractions. All three compounds produced a concentration-dependent relaxation of isolated rat detrusor strips (IC50 values = 0.93, 0.03, and 0.09 microM, respectively for ZD6169, celikalim, and WAY-133537. Contractile inhibition by all three compounds was fully reversed by 6 microM glyburide. These compounds also effectively inhibited spontaneous bladder contractions in the rat hypertrophied bladder model of detrusor instability. We also examined the electrophysiological properties of WAY-133537 on isolated rat bladder detrusor myocytes. Myocytes had an average resting membrane potential of -40 mV. Under patch current-clamp conditions, WAY-133537 (0.3 and 1.0 microM, n = 4-5) produced a significant hyperpolarization of 21 and 26 mV, respectively. Hyperpolarization was reversed by the addition of 5 microM glyburide. In patch voltage-clamp studies, WAY-133537 (0.3 microM, n = 3) significantly increased outward current in response to both voltage step and ramp protocols consistent with activation of the ATP-dependent potassium channel. In the detrusor instability model, WAY-133537 and celikalim had similar oral potencies (ED50 = 0.13 and 0.3 mg/kg, respectively), whereas ZD6169 was less potent (ED50 = 2.4 mg/kg). The antihypertensive agent celikalim exerted effects on the bladder at doses that significantly reduced systemic blood pressure. In contrast, both WAY-133537 and ZD6169 inhibited bladder hyperactivity at doses that produced minimal changes in both mean arterial blood pressure and heart rate. These data suggest that both WAY-133537 and ZD6169 may be useful in the treatment of bladder instability at doses associated with minimal hemodynamic side effects. (+info)Guanosine triphosphatase stimulation of oncogenic Ras mutants. (4/275)
Interest in the guanosine triphosphatase (GTPase) reaction of Ras as a molecular drug target stems from the observation that, in a large number of human tumors, Ras is characteristically mutated at codons 12 or 61, more rarely 13. Impaired GTPase activity, even in the presence of GTPase activating proteins, has been found to be the biochemical reason behind the oncogenicity of most Gly12/Gln61 mutations, thus preventing Ras from being switched off. Therefore, these oncogenic Ras mutants remain constitutively activated and contribute to the neoplastic phenotype of tumor cells. Here, we show that the guanosine 5'-triphosphate (GTP) analogue diaminobenzophenone-phosphoroamidate-GTP (DABP-GTP) is hydrolyzed by wild-type Ras but more efficiently by frequently occurring oncogenic Ras mutants, to yield guanosine 5'-diphosphate-bound inactive Ras and DABP-Pi. The reaction is independent of the presence of Gln61 and is most dramatically enhanced with Gly12 mutants. Thus, the defective GTPase reaction of the oncogenic Ras mutants can be rescued by using DABP-GTP instead of GTP, arguing that the GTPase switch of Ras is not irreversibly damaged. An exocyclic aromatic amino group of DABP-GTP is critical for the reaction and bypasses the putative rate-limiting step of the intrinsic Ras GTPase reaction. The crystal structures of Ras-bound DABP-beta,gamma-imido-GTP show a disordered switch I and identify the Gly12/Gly13 region as the hydrophobic patch to accommodate the DABP-moiety. The biochemical and structural studies help to define the requirements for the design of anti-Ras drugs aimed at the blocked GTPase reaction. (+info)The binding site for an inhibitor of squalene:hopene cyclase determined using photoaffinity labeling and molecular modeling. (5/275)
BACKGROUND: The squalene:hopene cyclases (SHCs) are bacterial enzymes that convert squalene into hopanoids, a function analogous to the action of oxidosqualene cyclases (OSCs) in eukaryotic steroid and triterpenoid biosynthesis. We have identified the binding site for a selective, potent, photoactivatable inhibitor of an SHC. RESULTS: SHC from Alicyclobacillus acidocaldarius was specifically labeled by [3H]Ro48-8071, a benzophenone-containing hypocholesteremic drug. Edman degradation of a peptide fragment of covalently modified SHC confirmed that Ala44 was specifically modified. Molecular modeling, using X-ray-derived protein coordinates and a single point constraint for the inhibitor, suggested several geometries by which Ro48-8071 could occupy the active site. CONCLUSIONS: A covalent complex of a potent inhibitor with a squalene cyclase has been characterized. The amino acid modification and molecular modeling suggest that Ro48-8071 binds at the junction between the central cavity and substrate entry channel, therefore inhibiting access of the substrate to the active site. (+info)A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat. (6/275)
The discovery that peroxisome proliferator-activated receptor (PPAR)-gamma was the molecular target of the thiazolidinedione class of antidiabetic agents suggested a key role for PPAR-gamma in the regulation of carbohydrate and lipid metabolism. Through the use of high-throughput biochemical assays, GW1929, a novel N-aryl tyrosine activator of human PPAR-gamma, was identified. Chronic oral administration of GW1929 or troglitazone to Zucker diabetic fatty (ZDF) rats resulted in dose-dependent decreases in daily glucose, free fatty acid, and triglyceride exposure compared with pretreatment values, as well as significant decreases in glycosylated hemoglobin. Whole body insulin sensitivity, as determined by the euglycemic-hyperinsulinemic clamp technique, was significantly increased in treated animals. Comparison of the magnitude of glucose lowering as a function of serum drug concentrations showed that GW1929 was 2 orders of magnitude more potent than troglitazone in vivo. These data were consistent with the relative in vitro potencies of GW1929 and troglitazone. Isolated perfused pancreas studies performed at the end of the study confirmed that pancreata from vehicle-treated rats showed no increase in insulin secretion in response to a step change in glucose from 3 to 10 mmol/l. In contrast, pancreata from animals treated with GW1929 showed a first- and second-phase insulin secretion pattern. Consistent with the functional data from the perfusion experiments, animals treated with the PPAR-gamma agonist had more normal islet architecture with preserved insulin staining compared with vehicle-treated ZDF rats. This is the first demonstration of in vivo efficacy of a novel nonthiazolidinedione identified as a high-affinity ligand for human PPAR-gamma. The increased potency of GW1929 compared with troglitazone both in vitro and in vivo may translate into improved clinical efficacy when used as monotherapy in type 2 diabetic patients. In addition, the significant improvement in daily meal tolerance may impact cardiovascular risk factor management in these patients. (+info)Effects of ZD6169, a K(ATP) channel opener, on the micturition reflex in the rat. (7/275)
The effects of ZD6169, a new ATP-sensitive potassium channel opener, on reflex urinary bladder activity were evaluated in urethane-anesthetized female Wistar rats. Continuous transvesical slow infusion cystometrograms (0.04 ml/min) were performed in untreated, capsaicin-pretreated (125 mg/kg s.c., 4 days before experiments) and capsaicin vehicle-pretreated rats. Intravesical infusion of ZD6169 in concentrations of 6, 15, 30, and 300 nM for 2 h at each concentration increased the intercontraction interval and pressure threshold for voiding in a concentration-dependent manner in untreated and vehicle-pretreated rats but not in capsaicin-pretreated animals. The effects appeared within 30 min after administration. ZD6169 did not alter baseline bladder pressure, duration of contractions, or the peak pressure during voiding. Glibenclamide (20 mg/kg i.v.) reversed the effects of ZD6169 (30 nM). During transvesical cystometrograms performed at a fast rate (0.21 ml/min), ZD6169 in concentrations between 6 and 300 nM did not alter the intercontraction interval or pressure threshold for voiding. ZD6169 produced smaller and more variable effects during slow transurethral cystometrograms. Capsaicin, a C-fiber afferent neurotoxin, administered s.c. 4 days before the experiment, produced similar changes and also eliminated the effect of ZD6169. These data suggest that ZD6169 raises the threshold for activation of C-fiber mechanoreceptors in the bladder wall and thereby increases the bladder volume for inducing reflex voiding. (+info)Differential and selective inhibition of protein kinase A and protein kinase C in intact cells by balanol congeners. (8/275)
The fungal metabolite balanol is a potent inhibitor of protein kinase A (PKA) and protein kinase C (PKC) in vitro that acts by competing with ATP for binding (K(i) approximately 4 nM); congeners of balanol show specificity for PKA over PKC. We have characterized the effects of balanol and 10"-deoxybalanol in intact cells to determine whether these compounds cross the cell membrane and whether the potency and specificity noted in vitro are preserved in vivo. In neonatal rat myocytes and cultured A431 cells transiently transfected with a cyclic AMP response element-luciferase reporter construct, balanol inhibits the induction of luciferase activity by isoproterenol, indicating inhibition of PKA. Western analysis shows that both balanol and 10"-deoxybalanol reduce phosphorylation of cAMP response element-binding protein in isoproterenol-stimulated A431 cells; inhibition is concentration dependent with an IC(50) value of approximately 3 microM. Balanol, but not 10"-deoxybalanol, inhibits phosphorylation of the myristoylated alanine-rich C kinase substrate protein, a PKC substrate, in phorbol ester-stimulated A431 cells (IC(50) approximately 7 microM). Our data demonstrate that balanol is a potent inhibitor of PKA and PKC in several whole-cell systems and causes no obvious toxicity. In addition, balanol congeners inhibit PKA and PKC with the specificity and potency predicted by in vitro experiments. (+info)
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Dispersive triplet excitation transport in organic glasses<...
Benzophenone oxime
2-Hydroxy-4-(2-ethylhexyloxy)benzophenone
Intermolecular Reductive
Coupling of Esters with Benzophenones
by Low-Valent Titanium: Synthesis of Diarylmethyl Ketones...
Thao md david associated with oxybenzone have interesting past
Abstracts
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CCCC 1984, Volume 49, Issue 1, Abstracts pp. 71-77
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Allergen of the Year
2014). Benzophenones named 2014 Contact Allergen of the Year Castanedo-Tardana, Mari Paz; Zug, Kathryn A. (2013). " ... Heurung, Ashley R.; Raju, Srihari I.; Warshaw, Erin M. (2014). "Benzophenones". Dermatitis. 25 (1): 3-10. doi:10.1097/DER. ... Benzophenones 2013 - Methylisothiazolinone - This chemical is used as a preservative in many cosmetics, lotions, and makeup ...
Tetrahydrofuran
Sodium/benzophenone. 48 hours. 43 ppm 3 Å molecular sieves (20% by volume). 72 hours. 4 ppm ...
Diphenyldichloromethane
Alternatively, benzophenone is treated with phosphorus pentachloride: (C6H5)2CO + PCl5 → (C6H5)2CCl2 + POCl3 It undergoes ... Andrews, L. J.; W. W. Kaeding (1951). "The Formation of Benzophenone and its Diethylketal in the Ethanolysis of ... Marvel, C. S.; Sperry, W. M. (1941). "Benzophenone". Organic Syntheses.; Collective Volume, 1, p. 95 Spaggiari, Alberto; ... hydrolysis to benzophenone. (C6H5)2CCl2 + H2O → (C6H5)2CO + 2 HCl It is used in the synthesis of tetraphenylethylene, ...
Photoelectrochemical process
Cadmium; some of the noble gases, for example xenon; zinc; benzophenone; and a large number of organic dyes, are also used as ...
Geminal halide hydrolysis
Stephen aldehyde synthesis Marvel, C. S.; Sperry, W. M. (1928). "Benzophenone". Organic Syntheses. 8: 26. doi:10.15227/orgsyn. ...
Ketone
Acetone and benzophenone (C6H5C(O)C6H5) are symmetrical ketones. Acetophenone (C6H5C(O)CH3) is an unsymmetrical ketone. Many ... "Benzophenone". Organic Syntheses. 8: 26. doi:10.15227/orgsyn.008.0026. Furniss, Brian; Hannaford, Antony; Smith, Peter; ... for example acetone and benzophenone. These nonsystematic names are considered retained IUPAC names, although some introductory ...
Propolis
Clusia resin contains polyprenylated benzophenones. In some areas of Chile and Argentina Andean valleys, propolis contains ...
Garcinia pseudoguttifera
... benzophenone (vismiaphenone-C); and a new benzophenone, 2,2-dimethyl-8-benzoyl-3,7-dihydroxy-5-methoxy-6-(3-methyl-2-butenyl)-3 ... Four benzophenones have been isolated from Garcinia pseudoguttifera: 6-hydroxy-2,4-dimethoxy-3,5-bis(3-methyl-2-butenyl) ... Ali, Sadaquat; Goundar, Renee; Sotheeswaran, Subramaniam; Beaulieu, Christian; Spino, Claude (1 January 2000). "Benzophenones ... benzophenone (myrtiaphenone-A); 2,2-dimethyl-8-benzoyl-7-hydroxy-5-methoxy-6-(3-methyl-2-butenyl)benzopyran (myrtiaphenone-B); ...
Photoprotection
see Benzophenone). Oxybenzone, titanium oxide and octyl methoxycinnamate are photoprotective agents used in many sunscreens, ...
Sunscreen
Benzophenone-8 3% USA, AUS X X Oxybenzone Benzophenone-3, Eusolex 4360, Escalol 567 6% (US) 10% (AUS, EU) 5% (JP) EU, USA, AUS ... Benzophenone-9 Uvinul DS 49, CAS 3121-60-6, Sodium Dihydroxy Dimethoxy Disulfobenzophenone [67] 10% JP ... Currently, benzophenone-4 and ethylhexyl methoxycinnamate are the two sunscreens most commonly used in hair products. The ... 2-Hydroxy-4-Methoxybenzophenone-5-sulfonic acid, 3-Benzoyl-4-hydroxy-6-methoxybenzenesulfonic acid, Benzophenone-4, Escalol 577 ...
Hydrazone
... s Benzophenone hydrazone, an illustrative hydrazone Carbonyl cyanide m-chlorophenyl hydrazone Gyromitrin (Acetaldehyde ... an antihypertensive drug X-ray structure of DNP-derived hydrazone of benzophenone. Selected parameters: C=N, 128 pm; N-N, 1.38 ... "Benzophenone 2,4-dinitrophenylhydrazone". Acta Crystallographica Section E. 62 (12): o5686-o5688. doi:10.1107/S1600536806048112 ...
Nail polish
A typical stabilizer is benzophenone-1.. Types[edit]. Base coat[edit]. This type of nail polish is a clear, milky-colored, or ...
Phenylsodium
Benzophenone is proposed as an intermediate. 2NaPh + PhCOCl → Ph3CONa + NaCl Metallation reactions with phenylsodium proceed in ...
Dioxybenzone
... (benzophenone-8) is an organic compound used in sunscreen to block UVB and short-wave UVA (ultraviolet) rays. It ... is a derivative of benzophenone. It is a yellow powder with a melting point of 68 °C. It is insoluble in water, but moderately ...
Nail polish
A typical stabilizer is benzophenone-1. This type of nail polish is a clear, milky-colored, or opaque pink polish formula that ...
Diazirine
Benzophenones, which form reactive triplet carbonyl species upon irradiation, often require long periods of irradiation which ... Prestwich, Glenn D.; Dormán, György; Elliott, John T.; Marecak, Dale M.; Chaudhary, Anu (1997-02-01). "Benzophenone Photoprobes ...
Thioketone
It photooxidizes in air to benzophenone and sulfur. Since its discovery, a variety of related thiones have been prepared. ...
Diphenylcyclopropenone
Benzophenone Cyclopropenone Singh G, Lavanya M (January 2010). "Topical immunotherapy in alopecia areata". International ...
Ketone
Acetone and benzophenone (C6H5C(O)C6H5) are symmetrical ketones. Acetophenone (C6H5C(O)CH3) is an asymmetrical ketone. In the ... Marvel, C. S.; Sperry, W. M. (1928). "Benzophenone". Organic Syntheses. 8: 26. doi:10.15227/orgsyn.008.0026.. ... In this prototypical example involving benzophenone, the tetrahedral intermediate expels phenyl anion to give benzamide and ... for example acetone and benzophenone. These nonsystematic names are considered retained IUPAC names,[4] although some ...
Donald E. Pearson
D.E. Pearson; R.W. Brockman (1952). "The Effect of substituents on the Polargraphic Half-Wave Potentials of Benzophenones". ...
Ionic hydrogenation
Ketones such as benzophenones, and 1,1-disubstituted olefins are typical substrates. Hydrides of tungsten, chromium, osmium, ...
Balanol
Specifically, balanol's distal benzophenone ring is able to rotate. In fact, in complex with PKA, balanol's distal benzophenone ... The benzophenone and hexahydroazepane moieties are connected via an ester linkage, and the azepane and benzoyl moieties are ... For instance, balanol's benzophenone rings are positioned beside the glycine-rich loop and further from the more polar ... For instance, balanol's benzophenone ring interacts with numerous highly conserved residues in PKA such as Gly52, Phe54, Asp184 ...
UV filter
They fall into several structural classes: Benzophenones Benzophenone-3 (BP3) Benzophenone-4 (BP4) Salicylates Homosalate (HMS ... Benzophenones (BPs) are widely used in UV filters, fragrance enhancers, and plastic additives. The major sources of BP-3 are ... In the presence of other UV filters, Benzotriazole, and humic acids, Benzophenone -3 degradation was observed through the loss ... Liu, YS (2011). "Photostability of the UV filter benzophenone-3 and its effect on the photodegradation of benzotriazole in ...
Octocrylene
... can convert to benzophenone through a retro-aldol condensation. The reaction occurs slowly over time, yielding ... Downs, C. A.; DiNardo, Joseph C.; Stien, Didier; Rodrigues, Alice M. S.; Lebaron, Philippe (7 March 2021). "Benzophenone ... significant concentration of benzophenone in all commercial cosmetics tested formulated with octocrylene. In coral, octocrylene ...
Photolabile protecting group
Pirrung, M. C.; Roy, B. G.; Gadamsetty, S. (April 2010). "Structure-Reactivity Relationships in (2-Hydroxyethyl)benzophenone ...
Peroxide process
A similar process based on benzophenone has also been described. The final stage involves hydrolysis of the purified ketazine: ...
Benzofenon
Benzophenone. Dobavljeno iz "https://sh.wikipedia.org/w/index.php?title=Benzofenon&oldid=33626666" ...
Photodegradation
Typical UV-absorbers are hydroxy-substituted benzophenones, related to the chemicals used in sunscreen. Plastic bag Polymer ...
Haloxazolam
"Solid-phase microextraction and GC-ECD of benzophenones for detection of benzodiazepines in urine". Journal of Analytical ...
Melipona scutellaris
The characteristics shown by chemical analyses suggest the presence of benzophenones as active compounds. Therefore, ...
benzophenone (CHEBI:41308)
... has role plant metabolite (CHEBI:76924) benzophenone (CHEBI:41308) is a benzophenones (CHEBI:22726) ... CHEBI:41308 - benzophenone. Main. ChEBI Ontology. Automatic Xrefs. Reactions. Pathways. Models. .gridLayoutCellStructure { min- ... Benzophenone is widely used as a building block in organic synthesis, and as a photosensitizer and photo-initiator in UV-curing ... mesotrione (CHEBI:38321) has functional parent benzophenone (CHEBI:41308). Ro 48-8071 (CHEBI:101064) has functional parent ...
Benzophenone - Wikipedia
Benzophenone is a widely used building block in organic chemistry, being the parent diarylketone. Benzophenone can be used as a ... Benzophenone is used as an additive in flavorings or perfumes for "sweet-woody-geranium-like notes." Benzophenone is produced ... In 2014, benzophenones were named Contact Allergen of the Year by the American Contact Dermatitis Society. Benzophenone is an ... Substituted benzophenones such as oxybenzone and dioxybenzone are used in many sunscreens. The use of benzophenone-derivatives ...
Benzophenone-n - Wikipedia
Benzophenone-10 (mexenone, 2-hydroxy-4-methoxy-4-methyl-benzophenone) Benzophenone-11 (benzophenone-2 and benzophenone-6) ... Benzophenone-3 (oxybenzone) Benzophenone-4 (sulisobenzone) Benzophenone-5 (sulisobenzone sodium) Benzophenone-6 (2,2-dihydroxy ... Benzophenone-12 (octabenzone, used to protect plastics) Chemicalland21: Benzophenone Inhaltsstoffe Kosmetik: Benzophenone-11 ( ... 4-dimethoxybenzophenone) Benzophenone-7 (5-chloro-2-hydroxybenzophenone) Benzophenone-8 (dioxybenzone) Benzophenone-9 (sodium ...
Benzophenone-3 (BP-3) Factsheet | National Biomonitoring Program | CDC
2-(Trifluoromethyl)benzophenone
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
4-tert-Butyl-benzophenone
Benzophenone M20105
Toxicity Studies of Benzophenone Administered in Feed to F344/N Rats and B6C3F1 Mice (CASRN 119-61-9) ... Toxicology and Carcinogenesis Studies of Benzophenone (CASRN 119-61-9) in F344/N Rats and B6C3F1 Mice (Feed Studies) ... Citation: FINAL STUDY REPORT DEVELOPMENTAL TOXICITY EVALUATION FOR BENZOPHENONE (CASRN 119-61-9) ADMINISTERED BY GAVAGE TO NEW ... Citation: Final Study Report Developmental Toxicity Evaluation for Benzophenone (CASRN 119-61-9) Administered by Gavage to New ...
Products That Contain BENZOPHENONE-1 || Skin Deep® Cosmetics Database | EWG
2-(Dicyclohexylphosphino)benzophenone 95% | Sigma-Aldrich
4-(Bromomethyl)benzophenone 96% | Sigma-Aldrich
Benzophenone - Registration Dossier - ECHA
Benzophenone was administered in the diet to rats at target dose levels of 20 mg/kg bw/d for 90 days and 100 or 500 mg/kg bw/d ... Benzophenone was administered in the diet to rats at target dose levels of 20 mg/kg bw for 90 days and 100 or 500 mg/kg bw for ... The concentration of benzophenone in the low-, mid- and high-dose diets was evaluated at week 1 of the study and the ... Stability and homogeneity of benzophenone were determined in samples of the diets for the low- and high-dose groups obtained ...
Benzophenone - Registration Dossier - ECHA
Abstract for TER98005 on Benzophenone
Benzophenone had no adverse ef-fect on prenatal viability or the overall inci-dences of fetal malformations or variations. The ... In this study, benzophenone (100, 200, or 300 mg/kg/day) or its vehicle (0.5% methylcellulose) was administered to female CD ... Benzophenone occurs naturally in some fruits and is used commercially as a perfumery and flavoring ingredient. This study was ... Rebound increases in feed intake were noted at all doses of benzophenone from gd 15 to 18, and 18 to 19. The high dose showed a ...
4,4'-bis(dimethylamino)benzophenone - Substance Information - ECHA
Surface Photochemistry: Benzophenone as a Probe for the Study of Modified Cellulose Fibres
... L. F. Vieira Ferreira,1 A. I. Costa ... phenylpropiophenone and benzophenone inclusion complexes with calix[4], [6] and [8]arenes," Physical Chemistry Chemical Physics ... and zeolite surfaces on the excited triplet state of benzophenone, B. T. ; a spectroscopic and kinetic study," Photochemical & ... L. F. Vieira Ferreira, I. Ferreira Machado, J. P. Da Silva, and T. J. F. Branco, "Surface photochemistry: benzophenone as a ...
574-66-3 - Benzophenone oxime, 97% - A14037 - Alfa Aesar
Precautionary Statements: P280i-P264-P305+P351+P338-P310a-P301+P312a-P501a Wear eye/face protection. Wash thoroughly after handling. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Dispose of contents/container in accordance with local/regional/national/international regulations. ...
Benzophenone-5 | Cosmetics Info
Benzophenone-1, Benzophenone-3, Benzophenone-4, Benzophenone-5, Benzophenone-9 and Benzophenone-11 protect cosmetics and ... Benzophenone-1 and Benzophenone-3 are used mostly in the formulation of nail polishes and enamels. These Benzophenone ... The Food and Drug Administration (FDA) has approved the use of Benzophenone-3 and Benzophenone-4 as safe and effective, over- ... Benzophenone-3 was nonsensitizing and nonphototoxic. Benzophenones were nonmutagenic when tested both with and without ...
4,4′-Bis(dimethylamino)benzophenone, TCI America™
michlers ketone, 4,4-bis dimethylamino benzophenone, michler ketone, bis 4-dimethylamino phenyl methanone, bis 4- ... michlers ketone, 4,4-bis dimethylamino benzophenone, michler ketone, bis 4-dimethylamino phenyl methanone, bis 4- ... michlers ketone, 4,4-bis dimethylamino benzophenone, michler ketone, bis 4-dimethylamino phenyl methanone, bis 4- ...
SCCP Re-evaluates Toluene and Benzophenone-3
Products formulated with benzophenone-3 must read contains oxybenzone on their product labels due to allergies. Colipa ... In 2006, the SCCP stated that a dermal absorption study of benzophenone-3 in concentrations up to 10% was needed to calculate ... The European Commission (EC) is requesting opinions from its Scientific Committee on Consumer Products (SCCP) on benzophenone-3 ... recently applied for a maximum allowed concentration of benzophenone-3; therefore, the SCCP must determine whether the ...
119-61-9 - Benzophenone, 99% - Diphenyl ketone - A10739 - Alfa Aesar
Benzophenone is widely employed as a photo initiator in UV-curing applications such as inks, imaging and clear coatings in the ... For a review of the use of benzophenone as a triplet-sensitizer in photochemistry, see: Synthesis, 249 (1981). ... Cork as extractor phase for determination of benzophenone, triclocarban and parabens in aqueous samples. Anal. Chim. Acta 2015, ... Optimization of dispersive micro solid-phase extraction for the rapid determination of benzophenone-type ultraviolet absorbers ...
Benzophenone-4-iodoacetamide | C15H12INO2 - PubChem
Allergy to benzophenone | DermNet NZ
Allergy to benzophenones (oxybenzone, sulizobenzone, dioxybenzone, mexenone). Authoritative facts about the skin from DermNet ... Am I allergic to benzophenone?. Benzophenone allergy is diagnosed by performing patch tests with 5% benzophenone in petrolatum. ... Treatment of benzophenone allergy. Those diagnosed with benzophenone allergy should avoid exposure to benzophenone containing ... Benzophenone 3 (2-hydroxy-4-methoxyphenyl: oxybenzone). *Benzophenone 4 (2-hydroxy-4-methoxy benzophenone-5-sulfonic acid: ...
Draft Screening Assessment Methanone, diphenyl- (Benzophenone) - Canada.ca
Benzophenone) Chemical Abstracts Service Registry Number 119-61-9 Environment and Climate Change Canada Health Canada June 2018 ... it is rather benzophenone derivatives (i.e., benzophenone -1, benzophenone -2, or benzophenone -3) that are present in these ... benzophenone is used in the synthesis of benzophenone derivatives. In the United States, benzophenone is permitted for use in ... Various known or novel benzophenone derivatives, generally designated as benzophenone-1 through benzophenone-12, as well as ...
Chemical Database: Benzophenone, 2-(3-(diethylamino)propoxy)-, hydrogen phosphate (EnvironmentalChemistry.com)
This page contains information on the chemical Benzophenone, 2-(3-(diethylamino)propoxy)-, hydrogen phosphate including: 3 ... 2-(3-(Diethylamino) propoxy) benzophenone hydrogen phosphate*Benzophenone, 2-(3-(diethylamino) propoxy)-, hydrogen phosphate ... Benzophenone, 2-(3-(diethylamino) propoxy)-, hydrogen phosphate. Identifications. *CAS Number: 10429-26-2*Synonyms/Related:* ... Chemical Database - Benzophenone, 2-(3-(diethylamino)propoxy)-, hydrogen phosphate. EnvironmentalChemistry.com. 1995 - 2018. ...
Benzophenone Manufacturers, Suppliers & Exporters in India
Contact to Benzophenone Exporters in India, Benzophenone Wholesalers, Benzophenone Distributors and Traders from India. ... Deals in 3-acetylpyridine, N-Diethyl Phenyl Acetic Acid, N, 4-Dihydroxy Benzophenone, 4, 4,4-dihydroxy benzophenone, 4-Dichloro ... Deals in Benzophenone-3, Propyl Paraben, Myristic Acid, Vitamin E Acetate, Sodium Methyl Paraben, Methyl Paraben, Potassium ... Deals in Benzophenone, pharmaceutical bulk drug, clotrimazole ip, cyclizine hcl, cyclizine base bp, cetirizine hcl bp, ...
4,4'-bis(dimethylamino)benzophenone - Registry of SVHC intentions until outcome - ECHA
Chromatography | Free Full-Text | Field-Amplified Sample Injection-Micellar Electrokinetic Chromatography for the...
Reduction Of Benzophenone With Sodium Borohydride. | AntiEssays
Reduction of Benzophenone with Sodium Borohydride. Safety precaution: Sodium Borohydride Toxic & Irritant Wash spillages away ... Benzophenone Harmful & Irritant Wash spillages away with water Hydrochloric acid Corrosive & Irritant wash spillages away with ... To this the mixture of sodium borohydride and benzophenone was poured slowly into the beaker. The precipitate was collected ... Introduction In this experiment, we will see the reduction of the aromatic ketone benzophenone with sodium borohydride to ...
CAS No.1013-88-3,Benzophenone imine Suppliers,MSDS download
where to buy 1013-88-3(Benzophenone imine).Also offer free database of 1013-88-3(Benzophenone imine) including MSDS sheet( ... Product Name Benzophenone imine Synonyms Benzophenone imine;Benzophenone imine CAS: 1013-88-3 MF: - MW: - EINECS: - Welcome to ... Benzophenone imine Basic information Product Name: Benzophenone imine Synonyms: DIPHENYLMETHANIMINE;BENZHYDRYLIDENEAMINE; ... BENZOPHENONIMINE;BENZOPHENONE IMINE;Benzene. Henan Sunlake Enterprise Corporation is located in Henan Province , the central ...
Magnesium(i) reduction of benzophenone and anthracene: first structural characterisation of a magnesium ketyl - Chemical...
The reductions of benzophenone and anthracene with dimeric magnesium(i) complexes lead to thermally stable magnesium ketyl and ... benzophenone. and anthracene. : first structural characterisation of a magnesium ketyl. Cameron Jones,*a Lucia McDyre,b Damien ... benzophenone. and anthracene. : first structural characterisation of a magnesium ketyl. C. Jones, L. McDyre, D. M. Murphy and A ... benzophenone. and anthracene. with dimeric magnesium(I) complexes lead to thermally stable magnesium ketyl. and magnesium ...
OxybenzoneDiphenylReplaced by pheEffects of the Sunscreen UV FilterDerivativesMethanoneConcentrations of benzophenone-typeSunscreensPhotochemistryKetoneIngredientPhotosensitizerCarcinogenicityAmerican Contact Dermatitis SocietySynthesisParabensAbsorb and dissipateChemicalsCompoundsFormulaOrganicAssayAminoXanthonesProductsRatsSodiumAbsorptionCOMPOUNDUltraviolet absorbersExposureReactionKetonesMethylAbsorbersWidelyPowderOccurs naturallyUrinaryReductionHydrogenHydrazoneStabilizerConcentrationSedimentEstrogenicTriterpenesPhenolsSyntheticNaturallySpectroscopicDiphenylmethanol
Oxybenzone9
- Substituted benzophenones such as oxybenzone and dioxybenzone are used in some sunscreens. (ebi.ac.uk)
- As part of sunscreen products, which are OTC drugs in the United States, Benzophenone-3 (Oxybenzone) and Benzophenone-4 (Sulisobenzone) protect the skin from the harmful effects of the sun. (cosmeticsinfo.org)
- Products formulated with benzophenone-3 must read 'contains oxybenzone' on their product labels due to allergies. (skininc.com)
- Benzophenones, including oxybenzone, combined with other sunscreen agents still provide excellent sun protection. (dermnetnz.org)
- Bluthgen N, Zucchi S, Fent K (2012) Effects of the UV filter benzophenone-3 (oxybenzone) at low concentrations in zebrafish (Danio rerio). (springer.com)
- Kannan says benzophenone-3, which appears on sunscreen labels as oxybenzone, is even more strongly estrogenic than bisphenol-A (BPA), a chemical found in certain plastics that's recently been the subject of regulatory scrutiny. (webmd.com)
- Benzophenone-1 is a chemical additive that's mostly used in nail polishes, according to the cosmetics industry web site CosmeticsInfo.org, but it also forms when the body breaks down oxybenzone, the major ingredient in sunscreen. (webmd.com)
- Substituted benzophenones such as oxybenzone and dioxybenzone are used in sunscreen. (shreejiexports.net)
- Oxybenzone (2-hydroxy-4-methoxyphenone, benzophenone-3) is one of the UV filters commonly found in sunscreens. (univ-amu.fr)
Diphenyl3
- Pursuant to section 74 of the Canadian Environmental Protection Act, 1999 (CEPA), the Minister of Environment and the Minister of Health have conducted a screening assessment of methanone, diphenyl-, herein referred to as benzophenone. (canada.ca)
- Pursuant to section 74 of the Canadian Environmental Protection Act, 1999 (CEPA) (Canada 1999), the Minister of the Environment and the Minister of Health have conducted a screening assessment of methanone, diphenyl-, herein referred to as benzophenone (BP), to determine whether this substance presents or may present a risk to the environment or to human health. (canada.ca)
- Benzophenone, an aromatic ketones (diphenyl ketone), is an important compound in organic photochemistry and perfumery as well as in organic synthesis. (chemicalland21.com)
Replaced by phe1
- The simplest member of the class of benzophenones, being formaldehyde in which both hydrogens are replaced by phenyl groups. (ebi.ac.uk)
Effects of the Sunscreen UV Filter1
- Toxicological effects of the sunscreen UV filter, benzophenone-2, on planulae and in vitro cells of the coral, Stylophora pistillata. (semanticscholar.org)
Derivatives9
- The use of benzophenone-derivatives which structurally resemble a strong photosensitizer has been criticized (see sunscreen controversy). (wikipedia.org)
- The high-strength polymer PEEK is prepared from derivatives of benzophenone. (wikipedia.org)
- Benzophenone derivatives are known to be pharmacologically active. (wikipedia.org)
- The four main benzophenone derivatives that have been used widely in sunscreens and cosmetics are listed below. (dermnetnz.org)
- In benzophenone allergic individuals, products containing benzophenone or benzophenone derivatives may cause redness, swelling, itching and fluid-filled blisters. (dermnetnz.org)
- Read product labels and avoid products that contain benzophenone or any of its derivatives. (dermnetnz.org)
- In toluene under reflux complexes 3, 4, 7, and 8 react with benzophenone imine and 2-vinylpyridine to afford the metalated derivatives (M = Ru (11), Os (12)) and (M = Ru (13), Os (14)), releasing benzene and styrene. (csic.es)
- HPLC allowed their quantification in all resins, revealing a distribution of benzophenone derivatives distinct from each other. (uchile.cl)
- 5 . A photosensitive composition according to claim 1 comprising in addition to the components (A), (B) and (C) at least one photosensitizer compound (E) selected from the group consisting of benzophenone and its derivatives, thioxanthone and its derivatives, anthraquinone and its derivatives, and coumarin and its derivatives. (google.com)
Methanone1
- Bis(trifluoromethyl) benzophenone Bis[4-(trifluoromethyl)phenyl]methanone CAS 21084-22-0 EINECS Product description: 3,4'-Bis(trifluoromethyl) benzophenone ,White to light yellow crystalline powder, pharmaceutical intermediates and materials intermediates. (peerflix.com)
Concentrations of benzophenone-type1
- Urinary concentrations of benzophenone-type UV filters in U.S. women and their association with endometriosis. (semanticscholar.org)
Sunscreens7
- These Benzophenone ingredients are also used in bath products, makeup products, hair products, sunscreens and skin care products. (cosmeticsinfo.org)
- Often benzophenone is used in combination with other chemical absorbing sunscreens to augment and stabilise the final product. (dermnetnz.org)
- People may be exposed through dermal application of sunscreens and cosmetic products.Small amounts of benzophenone-3 can be absorbed through human skin and excreted in the urine, mostly as a glucuronidated conjugate (Gonzalez et al. (cdc.gov)
- Gustavsson Gonzalez H, Farbrot A, Larko O.Percutaneous absorption of benzophenone-3, a common component of topical sunscreens. (cdc.gov)
- First used as a preserver to extend the shelf life of paints, varnishes, and other industrial products, benzophenones were added to sunscreens in the 1950s. (thefreedictionary.com)
- Benzophenone-3 is often used in sunscreens as well as in synthetic resins and polymers. (foodpackagingforum.org)
- Urinary concentrations of two benzophenone-type ultraviolet filters (BP-2, BP-8), chemicals used as sunscreens, were found to be associated with select semen endpoints. (fertstertforum.com)
Photochemistry1
- Benzophenone is a common photosensitizer in photochemistry. (wikipedia.org)
Ketone2
- Introduction In this experiment, we will see the reduction of the aromatic ketone benzophenone with sodium borohydride to diphenylmethanol. (antiessays.com)
- Benzophenone is an aromatic ketone, generally used in cosmetic products as ultraviolet (UV) absorber however it is suspected of causing cancer and toxic to aquatic life with long-term effects [ 1 ]. (analchem.net)
Ingredient3
- Benzophenone occurs naturally in some fruits and is used commercially as a perfumery and flavoring ingredient. (nih.gov)
- It is also used as a UV stabilizer in plastic surface coatings and polymers.Benzophenone-3 is a common ingredient in sun-blocking agents. (cdc.gov)
- Benzophenone is used as flavor ingredient, a fragrance enhancer, a perfume fixative, and an additive for plastics coating and adhesive formulations. (analchem.net)
Photosensitizer2
- Benzophenone is widely used as a building block in organic synthesis, and as a photosensitizer and photo-initiator in UV-curing applications such as inks, imaging, and clear coatings in the printing industry. (ebi.ac.uk)
- Computational Study of the Radical Mediated Mechanism of the Formation of C8, C5, and C4 Guanine:Lysine Adducts in the Presence of the Benzophenone Photosensitizer. (semanticscholar.org)
Carcinogenicity3
- IARC determined that there is sufficient evidence in laboratory animals for the carcinogenicity of benzophenone. (canada.ca)
- 1994).IARC and NTP have no ratings as to human carcinogenicity of benzophenone-3. (cdc.gov)
- Besides its high usability as industrial chemical, it contributes to carcinogenicity due to the high reactivity and instability of benzophenone anion (benzophenone work via formation of an anion). (analchem.net)
American Contact Dermatitis Society2
- In 2014, benzophenones were named Contact Allergen of the Year by the American Contact Dermatitis Society. (wikipedia.org)
- Because they commonly cause contact allergic dermatitis , benzophenones were declared the Contact Allergen of the Year for 2014 by the American Contact Dermatitis Society (ACDS). (dermnetnz.org)
Synthesis3
- benzophenone hydrazone is used in the antibiotics synthesis of 6-APA and 7-ACA of the carboxyl protecting groups and other organic compounds. (ydachem.com)
- Benzophenone is not a precursor for the synthesis of another compound of olfactory interest. (scentree.co)
- Benzophenone-N-ethyl piperidine ether analogues--synthesis and efficacy as anti-inflammatory agent. (sparrho.com)
Parabens5
- Carasek, E. A novel approach to bar adsorptive microextraction: Cork as extractor phase for determination of benzophenone, triclocarban and parabens in aqueous samples. (alfa.com)
- Exposure to environmental phenols (e.g., bisphenol A, benzophenone-3, and triclosan) and parabens is widespread in the population. (nih.gov)
- We examined the association of bisphenol A (BPA), benzophenone-3 (BP-3), triclosan (TCS), and parabens with serum total testosterone (TT) levels in child and adolescent participants (ages 6-19 years) in the National Health and Nutrition Examination Survey (NHANES) 2011-2012. (nih.gov)
- They found that four sunscreen chemicals--parabens, cinnamates, benzophenones and a camphor derivative--cause the viruses to replicate until their algae hosts explode, spilling virus particles into the surrounding seawater, where they can infect neighbouring coral communities. (thefreedictionary.com)
- We have developed a sensitive method for measuring BPA, 4-tert-octylphenol (tOP), benzophenone-3 (BP-3), one chlorophenols triclosan, and four parabens. (cdc.gov)
Absorb and dissipate2
- Benzophenone ingredients absorb and dissipate UV radiation, which serves to protect cosmetics and personal care products. (cosmeticsinfo.org)
- Background The capability of benzophenone-3 (BP-3) to absorb and dissipate ultraviolet radiation facilitates its use as a sunscreen agent. (cdc.gov)
Chemicals3
- The study, which is published in Environmental Science & Technology , measured concentrations of five kinds of chemicals called benzophenones in the urine of more than 600 women who were evaluated for endometriosis . (webmd.com)
- Its relationship with Viachem, a supplier of specialty and fine chemicals, enables the company to increase market share for its MAXGARD brand of substituted benzophenones , according to Jimmy Wooten, global product manager for Syrgis Performance Specialties. (thefreedictionary.com)
- To assess benzophenone-type ultraviolet (UV) filter concentrations, chemicals used in sunscreen and personal care products, and semen endpoints. (fertstertforum.com)
Compounds3
- Through the structure-activity relationship, we found that an increase in the number of methyl, chloro and fluoro groups in a benzophenone ring on compound 9d resulted in higher potency compared to other compounds. (rsc.org)
- Series of compounds having benzophenone moiety were designed. (ebscohost.com)
- This study describes a procedure for determining eight benzophenone-derived compounds in surface waters and sediments. (nih.gov)
Formula2
- Benzophenone is the organic compound with the formula (C6H5)2CO, generally abbreviated Ph2CO. (wikipedia.org)
- Benzophenone -3 Molecular Formula:C14H12O3 Package: 25kg/drum 2. (peerflix.com)
Organic5
- Benzophenone is a widely used building block in organic chemistry, being the parent diarylketone. (wikipedia.org)
- The ecological risk of benzophenone was characterized using the ecological risk classification of organic substances (ERC). (canada.ca)
- Benzophenones can act as optical filters or deactivate substrate molecules that have been excited by light for the protection polymers and organic substances. (chemicalland21.com)
- Benzophenone Hydrazone is the organic compound, widely used building block in organic chemistry. (shreejiexports.net)
- Contact Now Supply Pharma Intermediate of benzophenone Benzophenone is ultraviolet absorbent, organic pigment, medicine, spices, pesticide intermediates. (mwprochem.com)
Assay1
- In carrageenan-induced foot pad edema assay, benzophenone analogues showed an interesting anti-inflammatory activity. (sparrho.com)
Amino4
- Synthetic access to these is possible using the Ni-[(Benzylprolyl)amino]benzophenone (BPB) complex as a chiral auxiliary. (strath.ac.uk)
- Prominent & Leading Wholesale Trader from Delhi, we offer benzophenone 3, amino silicon emulsion cs 618, polyquaternium 10, methyl paraben, myristic acid and cctg powder. (continentalchemicals.in)
- Interactions of benzophenone (BP) with the Torpedo nicotinic acetylcholine receptor (nAChR) were characterized by electrophysiological analyses, radioligand binding assays, and photolabeling of nAChR-rich membranes with [3H]BP to identify the amino acids contributing to its binding sites. (edu.au)
- N -(Alkoxycarbonyl)-( S )-α-amino acid methyl esters gave optically active diphenylmethyl ketones by reduction with benzophenone. (figshare.com)
Xanthones1
- Antibacterial and Antioxidant Xanthones and Benzophenone from Garcinia smeathmannii", Planta Medica , vol. 81, 2015, pp. 594-599. (uni-bielefeld.de)
Products17
- Benzophenone prevents ultraviolet (UV) light from damaging scents and colors in products such as perfumes and soaps. (wikipedia.org)
- In cosmetics and personal care products, Benzophenone-1 and Benzophenone-3 are used mostly in the formulation of nail polishes and enamels. (cosmeticsinfo.org)
- Benzophenone-1, Benzophenone-3, Benzophenone-4, Benzophenone-5, Benzophenone-9 and Benzophenone-11 protect cosmetics and personal care products from deterioration by absorbing, reflecting, or scattering UV rays. (cosmeticsinfo.org)
- The CIR Expert Panel evaluated the scientific data and concluded that Benzophenone-1, -3, -4, -5, -9 and -11 were safe for use in cosmetics and personal care products. (cosmeticsinfo.org)
- The European Commission (EC) is requesting opinions from its Scientific Committee on Consumer Products (SCCP) on benzophenone-3 and toluene. (skininc.com)
- The first contact reaction to benzophenones in sunscreen products was first documented in 1972. (dermnetnz.org)
- Those diagnosed with benzophenone allergy should avoid exposure to benzophenone containing products. (dermnetnz.org)
- A comparison of estimated levels of exposure to benzophenone associated with the use of certain products (i.e., nail polish and interior paint) and critical effect levels results in margins of exposure that are potentially inadequate to account for uncertainties in the health effects and exposure databases. (canada.ca)
- These include the pharmaceutical ketoprofen, its phototransformation products 3-ethylbenzophenone and 3-acetylbenzophenone, and five benzophenone-type ultraviolet (UV) filters. (nih.gov)
- Benzophenones are used in a variety of products because they protect against UV light. (webmd.com)
- Phenols are also used as sunscreen agents for skin protection, and as UV filters in cosmetic products and plastics to improve stability (e.g., benzophenone-3 [BP-3]), or used as bactericides (e.g., triclosan) in soap and other personal care products. (cdc.gov)
- When benzophenone reduces to diphenylmethanol, leftover products include the CH2OH and NaBH3 species. (sciencing.com)
- We doesn't provide benzophenone 4 uses products or service, please contact them directly and verify their companies info carefully. (peerflix.com)
- A chemical linked to cancer, benzophenone is used in cosmetics such as lip balm and nail polish to protect the products from UV light. (safecosmetics.org)
- The reductive coupling of aliphatic esters with benzophenones by Zn-TiCl 4 in THF gave two- and four-electron reduced products, diaryl-(hydroxy)-methyl ketones, and diarylmethyl ketones selectively by controlling the reaction conditions. (figshare.com)
- In the reaction of aromatic esters with benzophenones, diarylmethyl ketones were obtained as the sole products. (figshare.com)
- The use of benzophenone allows manufacturers to package the products in clear glass or plastic without which, opaque or dark packaging would be required [ 6 ]. (analchem.net)
Rats5
- Dose selection was based on a screening study in which Sprague-Dawley-derived (CD) rats were treated by gavage with benzophenone (0, 25, 50, 100, 200, or 300 mg/kg body weight/day) on gestational days 6 through 19 (NTP, 1998b). (nih.gov)
- In this study, benzophenone (100, 200, or 300 mg/kg/day) or its vehicle (0.5% methylcellulose) was administered to female CD rats by gavage on gd 6 through 19. (nih.gov)
- Chronic exposure to benzophenone via the oral route caused cancer in rats and mice. (canada.ca)
- The ultraviolet filter benzophenone 2 interferes with the thyroid hormone axis in rats and is a potent in vitro inhibitor of human recombinant thyroid peroxidase. (thefreedictionary.com)
- It was found that exposure to benzophenone-3 in rats led to an increase of non-neoplastic lesions of the testis and pancreas in males and of the uterus and adrenal cortex in females. (foodpackagingforum.org)
Sodium4
- Reduction Of Benzophenone With Sodium Borohydride. (antiessays.com)
- To this the mixture of sodium borohydride and benzophenone was poured slowly into the beaker. (antiessays.com)
- This is determined to be 1.90 × 107 s-1 for benzophenone (BP) and 1.83 × 107 s-1 for decafluorobenzophenone in sodium dodecyl sulfate (SDS) micelles, indicating that this value is not limited by the rate of spin mixing, and thus that the kinetic approach used is justified. (le.ac.uk)
- Benzophenone reacts with sodium borohydride in a methanol solution. (sciencing.com)
Absorption4
- In 2006, the SCCP stated that a dermal absorption study of benzophenone-3 in concentrations up to 10% was needed to calculate the ingredient's margin of safety under proposed conditions of use. (skininc.com)
- More facts of improper selection of gonzalez h, farbrot a, larko o, wennberg am: percutaneous absorption of the sunscreen benzophenone-3 after repeated whole-body applications, with and without ultraviolet irradiation. (casinoreviewsnow.com)
- According to gonzalez h, farbrot a, larko o, wennberg am: percutaneous absorption of the sunscreen benzophenone - 3 after several repeated whole - body applications, with and without ultraviolet irradiation. (casinoreviewsnow.com)
- Benzophenone -3 segment UVB UVA absorption sunscreen as assist in the absorber, the addition of UV protection and enchanced SPF activity, oil soluble powder, safe use . (peerflix.com)
COMPOUND1
- Benzophenone is a compound of the scent principle of grapes, black tea and papaya among others. (scentree.co)
Ultraviolet absorbers1
- Ding, W. H. Optimization of dispersive micro solid-phase extraction for the rapid determination of benzophenone-type ultraviolet absorbers in aqueous samples. (alfa.com)
Exposure1
- Urinary benzophenone-3 levels include both conjugated and unconjugated forms and reflect recent exposure to the chemical. (cdc.gov)
Reaction6
- Another, less well-known reaction to produce benzophenone is the pyrolysis of anhydrous calcium benzoate. (wikipedia.org)
- The hydrogen abstraction reaction of benzophenones in micellar interiors was studied by the effect of a short, resonant microwave pulse on the recombination kinetics under magnetic fields of approximately 0.3 T. This technique allows all the significant rate constants in the reaction to be determined, in particular the singlet state recombination rate constant, which is very difficult to accurately determine by other techniques. (le.ac.uk)
- Benzhydrylamines can be synthesized from benzophenones by the Leuckart reaction via the intermediate benzhydrylformamides. (thefreedictionary.com)
- Focusing on one benzophenone molecule at a time is helpful for explaining and understanding reaction steps. (sciencing.com)
- Benzophenone can be synthesized by a Friedel-Craft reaction from benzene by reaction with benzoyl chloride in the catalytic presence of aluminum chloride (Lewis acid). (scentree.co)
- These results suggested that biofield treatment has significantly altered the thermal, spectroscopic, and chemical properties of benzophenone, which could make them more useful as reaction intermediate in industrial applications. (analchem.net)
Ketones2
- The Benzophenones are a group of aromatic ketones, all of which contain the diphenylketone structural element. (cosmeticsinfo.org)
- The benzophenones are a group of aromatic ketones that have both pharmaceutical and industrial applications. (dermnetnz.org)
Methyl1
- Novel benzophenone analogs ( 9a-d and 10a-d ) substituted with methyl, chloro and fluoro groups at different positions on an identical chemical backbone and incorporating variations in the number of substituents have been synthesized in a multistep process and characterized. (rsc.org)
Absorbers1
- Benzphenone-1 - benzophenone-12 (BP-1 -BP-12) are UVA/UVB absorbers. (wikipedia.org)
Widely1
- Benzophenone is widely employed as a photo initiator in UV-curing applications such as inks, imaging and clear coatings in the printing industry. (alfa.com)
Powder1
- Sun filter materials powder Benzophenone -3 prevent from UVB, UVA 1. (isp.org.cn)
Occurs naturally2
Urinary5
- The NHANES 2003-2004 levels of urinary benzophenone-3 have been described by Calafat et al. (cdc.gov)
- Higher urinary benzophenone-3 levels also are apparent in non-Hispanic whites and females in NHANES 2005-2010 (CDC, 2012). (cdc.gov)
- In a study of 90 U.S. females aged 6-8 years, the median urinary benzophenone-3 level of 14.7 µg/L was comparable to the median levels of children 6-11 years of age (15.8-18.7 µg/L) in the NHANES 2003-2010 subsamples (Calafat et al. (cdc.gov)
- 2007).Total benzophenone-3 urinary concentrations were detectable in 90% of a small sample of adults in whom the values ranged up to 3000 µg/L (Ye et al. (cdc.gov)
- 2005). Following short-term application of 10% benzophenone-3 lotion, men and women had mean urinary levels of 140 and 60 µg/L, respectively (Janjua et al. (cdc.gov)
Reduction2
- The reduction starts with breaking the benzophenone carbon-oxygen double bond. (sciencing.com)
- This complex is the main second product of benzophenone reduction. (sciencing.com)
Hydrogen2
- Central carbon of benzophenone bonds with one hydrogen from borohydride (BH4), while the benzophenone oxygen briefly exists as an anion, which is a negatively charged atom. (sciencing.com)
- Since four benzophenone molecules each attract a hydrogen atom from the "BH4" hydrogen donor, four "CH2OH"s bond with each boron (B) atom. (sciencing.com)
Hydrazone1
- Holding a highly reputed and trusted market standing, we are engaged in offering Benzophenone Hydrazone . (shreejiexports.net)
Stabilizer1
- Benzophenone 4 is a photo stabilizer and sunscreen agent used for its ability to absorb UV rays. (skin-hairactives.com)
Concentration3
- The concentration of benzophenone in the low-, mid- and high-dose diets was evaluated at week 1 of the study and the concentration in the low-dose also was determined at week 6 and 13. (europa.eu)
- It is proposed to conclude that benzophenone does not meet the criteria under paragraphs 64(a) or (b) of CEPA as it is not entering the environment in a quantity or concentration or under conditions that have or may have an immediate or long-term harmful effect on the environment or its biological diversity or that constitute or may constitute a danger to the environment on which life depends. (canada.ca)
- On the basis of the information presented in this draft screening assessment, it is proposed to conclude that benzophenone meets the criteria under paragraph 64(c) of CEPA as it is entering the environment in a quantity or concentration or under conditions that constitute or may constitute a danger in Canada to human life or health. (canada.ca)
Sediment1
- Determination of benzotriazole and benzophenone UV filters in sediment and sewage sludge. (semanticscholar.org)
Estrogenic1
- Estrogenic potency of benzophenone UV filters in breast cancer cells: proliferative and transcriptional activity substantiated by docking analysis. (inserm.fr)
Triterpenes1
- while that of the propolis from Antioquia and Huila regions, were rich in prenylated benzophenones and triterpenes respectively (Table 1). (thefreedictionary.com)
Phenols1
- One class of EDCs is the environmental phenols, which includes bisphenol A (BPA), triclosan (TCS), and benzophenone-3 (BP-3). (nih.gov)
Synthetic2
- The angiopreventive and in vitro tumor inhibition activities of novel synthetic benzophenone analogs have been investigated intensively and explored in a very systematic way. (rsc.org)
- boiling point 305 - 306 C. Benzophenone is used as a constituent of synthetic perfumes and as a starting material for the manufacture of dyes, pesticides and drugs (especially anxiolytic and hypnotic drugs). (chemicalland21.com)
Naturally1
- Benzophenone-3 (BP-3) is a naturally occurring chemical found in some flowering plants. (cdc.gov)
Spectroscopic1
- The aim of the present study was to evaluate the impact of biofield energy treatment on the thermal, spectroscopic, and chemical properties of benzophenone. (analchem.net)
Diphenylmethanol1
- By using TLC and IR spectrum, we will see the difference between benzophenone (starting material) and diphenylmethanol (final product). (antiessays.com)