Compounds that contain a BENZENE ring fused to a furan ring.
Compounds of the general formula R-O-R arranged in a ring or crown formation.
A vasodilator that also has bronchodilatory action. It has been employed in the treatment of angina pectoris, in the treatment of asthma, and in conjunction with ultraviolet light A, has been tried in the treatment of vitiligo. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1024)
A plant genus of the family FABACEAE that is a source of psoralen (FICUSIN).
An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.
A plant family of the order Theales.
A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.
The concentration of a compound needed to reduce population growth of organisms, including eukaryotic cells, by 50% in vitro. Though often expressed to denote in vitro antibacterial activity, it is also used as a benchmark for cytotoxicity to eukaryotic cells in culture.
Any compound that contains a constituent sugar, in which the hydroxyl group attached to the first carbon is substituted by an alcoholic, phenolic, or other group. They are named specifically for the sugar contained, such as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc. Upon hydrolysis, a sugar and nonsugar component (aglycone) are formed. (From Dorland, 28th ed; From Miall's Dictionary of Chemistry, 5th ed)
Agents that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
Ion channels that specifically allow the passage of SODIUM ions. A variety of specific sodium channel subtypes are involved in serving specialized functions such as neuronal signaling, CARDIAC MUSCLE contraction, and KIDNEY function.
A by-product of the destructive distillation of coal used as a topical antieczematic. It is an antipruritic and keratoplastic agent used also in the treatment of psoriasis and other skin conditions. Occupational exposure to soots, tars, and certain mineral oils is known to be carcinogenic according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985) (Merck Index, 11th ed).
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
Unsaturated hydrocarbons of the type Cn-H2n, indicated by the suffix -ene. (Grant & Hackh's Chemical Dictionary, 5th ed, p408)
Synthetic or naturally occurring substances related to coumarin, the delta-lactone of coumarinic acid.
Inorganic compounds that contain bromine as an integral part of the molecule.
A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.
Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
A quantitative prediction of the biological, ecotoxicological or pharmaceutical activity of a molecule. It is based upon structure and activity information gathered from a series of similar compounds.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
The molecular designing of drugs for specific purposes (such as DNA-binding, enzyme inhibition, anti-cancer efficacy, etc.) based on knowledge of molecular properties such as activity of functional groups, molecular geometry, and electronic structure, and also on information cataloged on analogous molecules. Drug design is generally computer-assisted molecular modeling and does not include pharmacokinetics, dosage analysis, or drug administration analysis.
Hallucinogenic alkaloid isolated from the flowering heads (peyote) of Lophophora (formerly Anhalonium) williamsii, a Mexican cactus used in Indian religious rites and as an experimental psychotomimetic. Among its cellular effects are agonist actions at some types of serotonin receptors. It has no accepted therapeutic uses although it is legal for religious use by members of the Native American Church.

Beneficial effects of raxofelast (IRFI 016), a new hydrophilic vitamin E-like antioxidant, in carrageenan-induced pleurisy. (1/1327)

1. Peroxynitrite is a strong oxidant that results from reaction between NO and superoxide. It has been recently proposed that peroxynitrite plays a pathogenetic role in inflammatory processes. Here we have investigated the therapeutic efficacy of raxofelast, a new hydrophilic vitamin E-like antioxidant agent, in rats subjected to carrageenan-induced pleurisy. 2. In vivo treatment with raxofelast (5, 10, 20 mg kg(-1) intraperitoneally 5 min before carrageenan) prevented in a dose dependent manner carrageenan-induced pleural exudation and polymorphonuclear migration in rats subjected to carrageenan-induced pleurisy. Lung myeloperoxidase (MPO) activity and malondialdehyde (MDA) levels, as well as histological organ injury were significantly reduced by raxofelast. 3. Immunohistochemical analysis for nitrotyrosine, a footprint of peroxynitrite, revealed a positive staining in lungs from carrageenan-treated rats. No positive nitrotyrosine staining was found in the lungs of the carrageenan-treated rats, which received raxofelast (20 mg kg 1) treatment. 4. Furthermore, in vivo raxofelast (5, 10, 20 mg kg(-1)) treatment significantly reduced peroxynitrite formation as measured by the oxidation of the fluorescent dihydrorhodamine 123, prevented the appearance of DNA damage, the decrease in mitochondrial respiration and partially restored the cellular level of NAD+ in ex vivo macrophages harvested from the pleural cavity of rats subjected to carrageenan-induced pleurisy. 5. In conclusion, our study demonstrates that raxofelast, a new hydrophilic vitamin E-like antioxidant agent, exerts multiple protective effects in carrageenan-induced acute inflammation.  (+info)

Phase I study of Carzelesin (U-80,244) given (4-weekly) by intravenous bolus schedule. (2/1327)

Carzelesin is a cyclopropylpyrroloindole analogue which acts as a DNA-sequence-specific alkylating agent. In this phase I study, Carzelesin was given as a 4-weekly 10 min i.v. infusion to 51 patients with advanced solid tumours. Patients received a median of two courses (range 1-5) at one of nine dose levels: 24, 48, 96, 130, 150, 170, 210, 250 and 300 microg m(-2). According to NCI-CTC criteria, non-haematological toxicities (grade 1/2) included fever, nausea and vomiting, mucositis and anorexia, none of which was clearly dose related. The dose-limiting toxicity was haematological and consisted mainly of neutropenia and to a lesser extent thrombocytopenia. From the dose level 150 microg m(-2), the haematological toxicity (particularly thrombocytopenia) was delayed in onset, prolonged and cumulative in some patients. In several courses, double WBC nadirs occurred. The maximum tolerated dose for a single course was 300 microg m(-2). From the dose level 170 microg m(-2), the intended dose intensity could not be delivered to most patients receiving > 2 courses owing to cumulative haematological toxicity. The dose level with the best dose intensity for multiple courses was 150 microg m(-2). The pharmacokinetics of Carzelesin and its metabolites (U-76,073; U-76,074) have been established in 31 patients during the first course of treatment using a HPLC method. Carzelesin exhibited linear pharmacokinetics. The concentration of U-76,074 (active metabolite) extended above the lower limit of quantitation (1 ng ml(-1)) for short periods of time and only at the higher dose levels. There was no relationship between neutropenia and the AUC of the prodrug Carzelesin, but the presence of detectable plasma levels of the active metabolite U-76,074 was usually associated with a substantial decrease in ANC values.  (+info)

Identification of SK-951, a novel benzofuran derivative, as an agonist to 5-HT4 receptors. (3/1327)

The pharmacological profile of SK-951 ((-)4-amino-N-[2-(1-azabicyclo[3.3.0]octan-5-yl) ethyl]-5-chloro-2,3-dihydro-2-methylbenzo[b]furan-7-carboxamide hemifumarate) was identified in relation to serotonin 5-HT3 and 5-HT4 receptors by the receptor binding assay and functional studies. The receptor binding assay showed that SK-951 bound to the 5-HT3 receptor with a high affinity, to the 5-HT4 receptor with relatively higher affinity and to the muscarinic M2 receptor with a low affinity, but not to dopamine D1 and D2 and serotonin 5-HT1 and 5-HT2 and muscarinic M1 and M3 receptors. SK-951 caused relaxations of tunica muscularis mucosae preparations from rat esophagus which were precontracted with carbachol, and the effects were antagonized by GR113808, a selective 5-HT4 antagonist. In the longitudinal muscle with myenteric plexus (LMMP) preparations from guinea pig ileum, SK-951 enhanced the electrically-stimulated contraction of preparations in which the 5-HT1, 5-HT2 and 5-HT3 receptors were blocked, and it enhanced the electrically-stimulated release of [3H]acetylcholine (ACh). These effects of SK-951 were antagonized by GR113808. SK-951 inhibited the 5-HT3 receptor-mediated contractions. These results indicate that SK-951 possesses properties of an agonist for the 5-HT4 receptor and an antagonist for the 5-HT3 receptor. Thus, SK-951 is a new and potent 5-HT4-receptor agonist and causes contractions of guinea pig ileum mediated by enhancement of ACh release via the 5-HT4 receptor.  (+info)

Selective stimulation of colonic transit by the benzofuran 5HT4 agonist, prucalopride, in healthy humans. (4/1327)

BACKGROUND: Prucalopride (R093877) is a selective and specific 5HT4 agonist, the first of a new chemical class of benzofurans, with gastrointestinal prokinetic activities in vitro. AIMS: To evaluate the effects of prucalopride on gastrointestinal and colonic transit. METHODS: A validated scintigraphic technique was used to measure gastrointestinal and colonic transit over 48 hours in 50 healthy volunteers. For seven days, each subject received a daily dose of 0. 5, 1, 2, or 4 mg prucalopride, or placebo in a double blind, randomised fashion. The transit test was performed over the last 48 hours. RESULTS: There were significant accelerations of overall colonic transit at 4, 8, 24, and 48 hours (p<0.05) and proximal colonic emptying t1/2 (p<0.05). The 0.5, 2, and 4 mg doses of prucalopride were almost equally effective and accelerated colonic transit compared with placebo. Prucalopride did not significantly alter gastric emptying (p>0.5) or small bowel transit (overall p=0. 12). The medication appeared to be well tolerated during the seven day treatment of healthy subjects. CONCLUSION: Prucalopride accelerates colonic transit, partly by stimulating proximal colonic emptying, but does not alter gastric or small bowel transit in healthy human subjects. Prucalopride deserves further study in patients with constipation.  (+info)

Simultaneous SPECT studies of pre- and postsynaptic dopamine binding sites in baboons. (5/1327)

The central nervous system dopamine transporters (DATs) and dopamine D2/D3 receptors are implicated in a variety of neurological disorders. Both sites are also targets for drug treatment. With the successful development of [99mTc]TRODAT-1, single-isotope imaging studies using this ligand for DAT imaging can be complemented by additional use of 123I-labeled D2/D3 receptor ligand co-injected to assess both pre- and postsynaptic sites of the dopaminergic system simultaneously. METHODS: Twelve SPECT scans of the brain were obtained in two baboons after intravenous administration of 740 MBq (20 mCi) [99mTc]-TRODAT-1 (technetium, [2-[[2-[[[3-(4-chlorophenyl)-8-methyl-8-azabicyclo[3,2,1]oct-2-yl]methyl ](2-mercaptoethyl) amino]ethyl]-amino]ethanethiolato (3-)]- oxo-[1R-(exo-exo)]) and 185 MBq (5 mCi) [123I]iodobenzamide or [123I]iodobenzofuran. SPECT data were acquired by a triple-head gamma camera equipped with ultra-high-resolution fanbeam collimators (scan duration = 210 min). Two sets of SPECT data were obtained using energy windows of 15% centered on 140 keV for 99mTc and 10% asymmetric with a lower bound at 159 keV for 123I. After coregistration with MRI, region-of-interest analysis was performed using predefined templates from coregistered MRI. In blocking studies, baboons were pretreated with N-methyl-2beta-carbomethoxy-3beta-(4-fluorophenyl)tropane (CFT, 14 mg) or raclopride (14 mg) to block DAT or D2/D3 binding site, respectively. RESULTS: Image quality of dual-isotope studies was similar to that obtained from single-isotope studies. When one site was blocked with CFT or raclopride, the binding of the respective ligand to the other site was not affected. CONCLUSION: This is the first example that clearly demonstrates the feasibility of simultaneous imaging of both pre- and postsynaptic sites of the dopaminergic system in baboons with dual-isotope SPECT studies. With or without corrections for cross-contamination of 123I into the 99mTc window, striatum-to-cerebellum ratios (target-to-nontarget) of dual-isotope experiments did not differ significantly from single-isotope experiments. This method may be a valuable and cost-effective tool for gaining comprehensive information about the dopaminergic system in one SPECT imaging session.  (+info)

Affinity isolation of imidazoline binding proteins from rat brain using 5-amino-efaroxan as a ligand. (6/1327)

We have employed an amino derivative of the imidazoline ligand, efaroxan, to isolate imidazoline binding proteins from solubilised extracts of rat brain, by affinity chromatography. A number of proteins were specifically retained on the affinity column and one of these was immunoreactive with an antiserum raised against the ion conducting pore component of the ATP-sensitive potassium channel. Patch clamp experiments confirmed that, like its parent compound, amino-efaroxan blocks ATP-sensitive potassium channels in human pancreatic beta-cells and can stimulate the insulin secretion from these cells. The results reveal that a member of the ion conducting pore component family is strongly associated with imidazoline binding proteins in brain and in the endocrine pancreas.  (+info)

Reactivity of Cl-P(+)-Cl toward cyclic organic ethers. (7/1327)

The dichlorophosphenium ion (Cl-P(+)-Cl) undergoes a variety of reactions with cyclic organic ethers in the gas phase in a Fourier-transform ion cyclotron resonance mass spectrometer. Most of the reactions are initiated by Cl-P(+)-Cl-induced heterolytic C-O bond cleavage. However, the observed final products depend on the exact structure of the ether. For saturated ethers, e.g., tetrahydropyran, tetrahydrofuran, and 2-methyltetrahydrofuran, the most abundant ionic product corresponds to hydroxide abstraction by Cl-P(+)-Cl. This unexpected reaction is rationalized by a multistep mechanism that involves an initial heterolytic C-O bond cleavage accompanied by a 1,2-hydride shift, and that ultimately yields a resonance-stabilized allyl cation and HOPCl2. The process is estimated to be highly exothermic (AM1 calculations yield delta H = -(33-38) kcal mol(-1) for the ethers mentioned above). However, the adducts formed from most of the unsaturated ethers are unable to undergo hydride shifts and hence cannot react via this pathway. In some of these cases, e.g., for 2,5-dihydrofuran and 2,5-dihydro-3,4-benzofuran, the C-O bond heterolysis is followed by oxygen/chlorine exchange to yield the O=PCl radical and a resonance-stabilized carbocation (AM1 calculations yield delta H = -14 kcal mol(-1) for the reaction of 2,5-dihydro-3,4-benzofuran). Hydride abstraction by Cl-P(+)-Cl also yields an abundant product for these two ethers. On the other hand, the ethers with low ionization energies, such as 2,3-dihydrofuran and 2,3-dihydrobenzofuran, react with Cl-P(+)-Cl by electron transfer. Finally, a unique pathway, addition followed by elimination of HCl, dominates the reaction with furan. The observed reactions are rationalized by thermochemical data obtained from semiempirical molecular orbital calculations.  (+info)

Removal of dibenzofuran, dibenzo-p-dioxin, and 2-chlorodibenzo-p-dioxin from soils inoculated with Sphingomonas sp. strain RW1. (8/1327)

Removal of dibenzofuran, dibenzo-p-dioxin, and 2-chlorodibenzo-p-dioxin (2-CDD) (10 ppm each) from soil microcosms to final concentrations in the parts-per-billion range was affected by the addition of Sphingomonas sp. strain RW1. Rates and extents of removal were influenced by the density of RW1 organisms. For 2-CDD, the rate of removal was dependent on the content of soil organic matter (SOM), with half-life values ranging from 5.8 h (0% SOM) to 26.3 h (5.5% SOM).  (+info)

Define benzofuran. benzofuran synonyms, benzofuran pronunciation, benzofuran translation, English dictionary definition of benzofuran. n. A colorless liquid, C8H6O, found in coal tar and used to make thermoplastic resins for paints and varnishes. Also called coumarone . n a colourless...
TY - JOUR. T1 - Structure-dependent reduction in DNA I-compound adducts by polychlorinated dibenzofurans in female Sprague-Dawley rat liver. AU - Randerath, K.. AU - Randerath, E.. AU - Reddy, R.. AU - Narasimhan, T. R.. AU - Wang, X.. AU - Safe, S.. PY - 1992. Y1 - 1992. N2 - The effects of polychlorinated dibenzofurans (PCDFs) on hepatic I-compound DNA adducts in female Sprague-Dawley rats were determined at 2 dose levels. In the first experiments, rats (4 per group) were treated with each of 3 polychlorinated dibenzofuran (PCDF) congeners at 20 μg/kg/week or 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) at 10 μg/kg/week for 4 weeks. Effects on total I-compound levels when compared with age-matched control animals (corn oil) were as follows: control (116) , 1,2,4,7,8-pentachlorodibenzofuran (PeCDF) (112) , 1,2,3,7,8-PeCDF (93) , 2,3,4,7,8-PeCDF (91) , TCDD (72) where the numbers in parentheses were the number of I-compounds in 109 DNA nucleotides. In the second experiment, rats (5 per group) ...
Polychlorinated dibenzofurans (PCDFs) are a family of organic compounds with one or several of the hydrogens in the dibenzofuran structure replaced by chlorines. For example, 2,3,7,8-tetrachlorodibenzofuran (TCDF) has chlorine atoms substituted for each of the hydrogens on the number 2, 3, 7, and 8 carbons (see structure in the upper left corner of the second image). Polychlorinated dibenzofurans are much more toxic than the parent compounds, with properties and chemical structures similar to polychlorinated dibenzodioxins. These groups together are often inaccurately called dioxins. They are known teratogens, mutagens, and suspected human carcinogens. PCDFs tend to co-occur with polychlorinated dibenzodioxins (PCDDs). PCDFs can be formed by pyrolysis or incineration at temperatures below 1200 °C of chlorine containing products, such as PVC, PCBs, and other organochlorides, or of non-chlorine containing products in the presence of chlorine donors. Dibenzofurans are known persistent organic ...
The domino three-component coupling reaction of arynes with DMF and active methylenes or methines was studied as a highly efficient method for preparing heterocycles. Coumarin derivative 5 was formed when diethyl malonate (2) or α-bromomalonate (3) were used as a C2-unit. In contrast, dihydrobenzofurans 7a and 7b were obtained by using α-chloroenolates generated from α-chloromalonates 4a and 4b and Et2Zn. The benzofuran 15a could be obtained by using ethyl iodoacetate (14) as a C1-unit. The one-pot conversion of dihydrobenzofurans 7a, 7b and 8a into benzofurans 15a and 15b was also studied. The direct synthesis of benzofuran 15b was achieved by using the active methine 18 having ketone and ester groups.
Allsop, David and Gibson, Gillian and Martin, Ian K. and Moore, Susan and Turnbull, Stuart and Twyman, Lance J. (2001) 3-p-toluoyl-2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran and 2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran do not act as surfactants or micelles when inhibiting the aggregation of β-amyloid peptide. Bioorganic and Medicinal Chemistry Letters, 11 (2). pp. 255-257. ISSN 0960-894X Full text not available from this repository ...
This report provides a national inventory of olychlorinated dibenzo-p-dioxin and polychlorinated dibenzofuran emissions to air, land and water from known sources for 2012, together with estimates of the amount of polychlorinated dibenzo-p-dioxin and polychlorinated dibenzofuran present within reservoir sources. Polychlorinated dibenzo-p-dioxin and polychlorinated dibenzofuran Read more ...
This report provides a national inventory of olychlorinated dibenzo-p-dioxin and polychlorinated dibenzofuran emissions to air, land and water from known sources for 2012, together with estimates of the amount of polychlorinated dibenzo-p-dioxin and polychlorinated dibenzofuran present within reservoir sources. Polychlorinated dibenzo-p-dioxin and polychlorinated dibenzofuran Read more ...
Metabolism and pharmacokinetics of 3-n-butylphthalide (NBP) in humans: the role of cytochrome P450s and alcohol dehydrogenase in biotransformation. - Xingxing Diao, Pan Deng, Cen Xie, Xiuli Li, Dafang Zhong, Yifan Zhang, Xiaoyan Chen
Article Multiple lines of evidence risk assessment of American robins exposed to polychlorinated dibenzofurans (PCDFS) and polychlorinated dibenzo‐P‐dioxins (PCDDS) in the Tittabawassee River floodplain, Midland, Michigan, USA. Concentrations of poly...
Bioactivation of 3-n-butylphthalide via sulfation of its major metabolite 3-hydroxy-NBP: mediated mainly by sulfotransferase 1A1. - Xingxing Diao, Xiaoyan Pang, Cen Xie, Zitao Guo, Dafang Zhong, Xiaoyan Chen
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
A series of fourteen methoxy substituted 2-benzoyl-1-benzofuran derivatives were synthesised and their affinities determined for adenosine A1 and A2A receptors via radioligand binding assays to establish the structure ...
Earlier, we reported on the design of sulfated benzofuran dimers (SBDs) as allosteric inhibitors of thrombin (Sidhu et al. J. Med. Chem.201154 5522-5531). To identify the site of binding of SBDs, we studied thrombin inhibition in the presence of exosite 1 and 2 ligands. Whereas hirudin peptide and heparin octasaccharide did not affect the IC(50) of thrombin inhibition by a high affinity SBD, the presence of full-length heparin reduced inhibition potency by 4-fold. The presence of γ fibrinogen peptide, which recognizes Arg93, Arg97, Arg173, Arg175, and other residues, resulted in a loss of affinity that correlated with the ideal Dixon-Webb competitive profile. Replacement of several arginines and lysines of exosite 2 with alanine did not affect thrombin inhibition potency, except for Arg173, which displayed a 22-fold reduction in IC(50). Docking studies suggested a hydrophobic patch around Arg173 as a plausible site of SBD binding to thrombin. The absence of the Arg173-like residue in factor Xa ...
The subject of the invention is benzofuran, benzothiophene, indole or indolizine compounds of general formula: ##STR1## in which: Het represents one of the groups: ##STR2## in which T,T and Treprese
80592-86-5 - ZLZINPAIXXXARB-UHFFFAOYSA-N - Benzofuran, 5-bromo-2-(diethylaminomethyl)-3-phenyl- - Similar structures search, synonyms, formulas, resource links, and other chemical information.
BUY 6-APB ONLINE, 6-(2-aminopropyl)benzofuran (also known as 6-APB or by the brand-name Benzofury) is a popular synthetic entactogen of the phenethylamine
Experimental studies have shown that dioxin-like chemicals may interfere with aspects of the endocrine system including growth. However, human background population studies are, however, scarce. We aimed to investigate whether early exposure of healthy infants to dioxin-like chemicals was associated …
Find out more about Lancaster Universitys research activities, view details of publications, outputs and awards and make contact with our researchers.
A total number of 120 healthy subjects (with an approximate 1:1 female:male ratio) are planned to be randomised.. Day 1: a baseline ECG profile. Day 1: Group 1 will receive prucalopride, Group 2a will receive moxifloxacin, and Group 2b will receive placebo.. On Day 5 (steady-state level is reached), a full ECG assessment day will be performed, enabling the comparison of prucalopride 2 mg with placebo.. Subsequently, the number of tablets will be escalated in all groups (blinded) with 1 tablet a day up to 5 tablets.. On Day 13 (steady state for the supratherapeutic dose level of 10 mg of prucalopride) another ECG assessment day will be performed, enabling a comparison of prucalopride 10 mg with placebo.. Group 2b will receive a single dose of moxifloxacin on Day 15. All subjects will be discharged on Day 16. Subjects will remain in the CRU throughout the treatment period.. All subjects will return for a follow-up visit on Day 30 (± 1 week) (approximately 14 days after the last dose). ...
Pharmacyclics, Inc. (Nasdaq: PCYC) today announced interim data from a Phase I study of their novel orally administered Brutons tyrosine kinase (Btk) inhibitor PCI-32765 in patients
Mycoremediation, or fungus-based remediation, is an ex situ form of bioaugmentation, in which hazardous organics are degraded or detoxified by fungi that are introduced into the contaminated soil via a fungal inoculum. Due to the ability of white-rot fungi (WRF) to degrade extremely recalcitrant contaminants (e.g., high-molecular-weight (HMW) polycyclic aromatic hydrocarbons (PAHs), polychlorinated dibenzo-p-dioxins (PCDDs), and polychlorinated dibenzofurans (PCDFs), work on fungus-based remediation has focused on the treatment of soils contaminated with these types of chemicals. In addition, work has progressed on the soil microbiology of mycoremediation and on the development of techniques to monitor the fate of fungi inoculated into soils. Fallout of PCDDs and PCDFs from combustion at incineration facilities has resulted in serious pollution of the surrounding soil environment because of their extremely high persistence and toxicity. Importantly, the extent of the enhancement varied with soil and
Benzofuran-2-carboxylic acid (4-amino-2-methyl-phenyl)-amide 433252-24-5 MSDS report, Benzofuran-2-carboxylic acid (4-amino-2-methyl-phenyl)-amide MSDS safety technical specifications search, Benzofuran-2-carboxylic acid (4-amino-2-methyl-phenyl)-amide safety information specifications ect.
Benzofuran-3(2H)-one 7169-34-8 MSDS report, Benzofuran-3(2H)-one MSDS safety technical specifications search, Benzofuran-3(2H)-one safety information specifications ect.
The biphenyl molecule is made up of two connected rings of six carbon atoms each, and a PCB is any molecule having multiple chlorines attached to the biphenyl nucleus. Two distinct classes of bacteria have now been identified that biodegrade PCBs by different mechanisms, including aerobic bacteria which live in oxygenated environments and anaerobic bacteria which live in oxygen free environments such as aquatic sediments. The aerobes attack PCBs oxidatively , breaking open the carbon ring and destroying the compounds. Anaerobes, on the other hand, leave the biphenyl rings intact while removing the chlorines. Polychlorinated dibenzo-p-dioxins (PCDD) and polychlorinated dibenzofurans (PCDF) were introduced into the biosphere on a large scale as by-products from the manufacture of chlorinated phenols and the incineration of wastes. Due to their high toxicity they have been the subject of great public and scientific scrutiny. The evidence in the literature suggests that PCDD/F compounds are subject ...
This is a Phase 2 multicenter, randomized, double-blind, placebo-controlled, add-on study of NBP softgel capsules for the treatment of mild to moderate cortical
Svante Arrhenius väg 8, Stockholm. Arrheniuslaboratoriet, Svante Arrhenius väg 16, Stockholm (Unit for Analytical and Toxicological Chemistry). Mailing address: ...
Vizard, C. G., Rimmer, D. L., Pless-Mulloli, T., Singleton, I., & Air, V. S. (2006). Identifying contemporary and historic sources of soil polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans in an industrial urban setting. Science of the Total Environment, 370(1), 61 - 69. https://doi.org/10.1016/j.scitotenv.2006.06.006. ...
1-benzofuran-2-yl{methyl[(3-pyridin-4-ylisoxazol-5-yl)methyl]amino}acetic acid|ChemBridge Corporation|1-benzofuran-2-yl[methyl...
We have developed a one-step synthesis of benzofurans from o-iodophenol and various terminal alkynes, by using Pd catalyst supported on nano-sized carbon balls (NCB) under copper- and ligand free conditions. This recyclable catalyst could be reused more than 5 times in the same heteroannulation reaction. The results have demonstrated that diverse 2-substituted benzofurans with tolerant functional groups can be prepared simply and conveniently under these conditions ...
Exposure to chlorinated dibenzo-p-dioxins (CDDs) (75 chemicals) occurs mainly from eating food that contains the chemicals. One chemical in this group, 2,3,7,8-tetrachlorodibenzo-p-dioxin or 2,3,7,8-TCDD, has been shown to be very toxic in animal studies. It causes effects on the skin and may cause cancer in people. This chemical has been found in at least 91 of 1,467 National Priorities List sites identified by the Environmental Protection Agency (EPA).
You are viewing an interactive 3D depiction of the molecule 6-methoxy-3-methyl-n-phenyl-n-[3-(1-piperidinyl)propyl]-1-benzofuran-2-carboxamide (C25H30N2O3) from the PQR.
N-(2-Fluorophenyl)-4-[5-[(3-methyl-1-benzofuran-2-carbonyl)amino]pyridin-2-yl]piperazine-1-carboxamide | C26H24FN5O3 | CID 52917631 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Structure, properties, spectra, suppliers and links for: Ethyl {[(2Z)-2-(2-furylmethylene)-3-oxo-2,3-dihydro-1-benzofuran-6-yl]oxy}acetate.
Structure, properties, spectra, suppliers and links for: Methyl {[(2Z)-3-oxo-2-(2,3,4-trimethoxybenzylidene)-2,3-dihydro-1-benzofuran-6-yl]oxy}acetate.
1-[(5-Nitro-2-phenyl-1-benzofuran-3-yl)methyl]piperidine | C20H20N2O3 | CID 558839 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
8-[5-(diethylamino)pentylamino]quinolin-6-ol,8-[5-(propan-2-ylamino)pentan-2-ylamino]quinolin-6-ol,8-(5-azanylpentylamino)quinolin-6-ol,8-acetamidooctadecanoic acid,8-heptylselanyloctanoic acid,8-methyl-3-phenyl-1,4-dioxaspiro[4.5]decane,8-methyl-5-nitro-quinoline,8-[bis(2-hydroxyethyl)amino]-1,3-dimethyl-7H-purine-2,6-dione,8,10-bis(oxidanylidene)-9-azaspiro[5.5]undecane-11-carbonitrile,8-fluoranylbenzo[e][2]benzofuran-1,3-dione,8-fluoranyl-4,5-dihydrobenzo[e][2]benzofuran-1,3-dione,8-fluoranyl-3,3-diphenyl-benzo[g][2]benzofuran-1-one,8-[[1,3-dimethyl-2,6-bis(oxidanylidene)-7H-purin-8-yl]methoxymethyl]-1,3-dimethyl-7H-purine-2,6-dione,8-chloranyl-7-(chloromethyl)-1,3-dimethyl-purine-2,6-dione,8-[bis(2-chloroethyl)aminomethyl]-1,3-dimethyl-7H-purine-2,6-dione,8-[bis(2-chloroethyl)aminomethyl]-3,7-dimethyl-purine-2,6-dione,8-[bis(2-chloroethyl)amino]-3,7-dimethyl-purine-2,6-dione,8-[bis(2-chloroethyl)amino]-1,3-dimethyl-7H-purine-2,6-dione,8-(diethylaminomethyl)-1,3,7-trimethyl-purine-2,6-dione,8
Kiamycin (1), a new angucyclinone derivative possessing an 1,12-epoxybenz[a]anthracene ring system, was isolated from your marine sp. indicated a 1,2,3-trisubstituted benzene ring by signals of in Hz) = 1.6 Hz), which requires a coplanar orientation of the connecting bonds. This is accomplished only if rings B and C will also be spp. [5,8,9,10,11,12]. None of them has an 11-oxabenzo[bc]aceanthrylene skeleton like 1. However, a similar benzofuran was created very easily as an intermediate in the synthesis of hatomarubigin [13]. 2.2. Biological Activity In the cytotoxicity checks, kiamycin (1) exhibited activity against human being cell lines, namely HL-60 (leukemia), lung adenocarcinoma cells A549, and the hepatoma cell series BEL-7402 with inhibition beliefs of 68.2%, 55.9%, and 31.7% at 100 M; adriamycin as positive control demonstrated inhibition prices of 70.0%, 79.3%, and 80.0%, respectively (Desk Trametinib 2). Both substances had been cytotoxicity against HL-60 equivalently, while 1 ...
Compositional information provided by the Sponsor indicated the presence of a number of isomers of the test item (2,6-dimethyl-3a-(propan-2-yl)octahydro-1-benzofuran), which in total represent the reported purity for this substance. Using this information, the calculation of the test item water solubility was calculated based on the total peak area of all peaks obtained on chromatographic analysis which were attributed to these isomers of the test item. On comparison of the relative peak/isomer responses for the test item standard and sample solutions, there was no evidence of significant selective solubility/extractivity, with all test item peaks/isomers being detected, at a similar ratio, on analysis of the water solubility sample solutions ...
4B11: Design and Synthesis of Inhibitors of Plasmodium Falciparum N-Myristoyltransferase, a Promising Target for Anti-Malarial Drug Discovery.
H(3) receptor antagonists based on a 2-aminoethylbenzofuran skeleton have been discovered, which are potent in vitro at human and rat H(3) receptors, with K(i) values of 0.1-5.8 nM. Analogues were discovered with potent (0.01-1 mg/kg) cognition and attention enhancing properties in animal models. On …
Sigma-Aldrich offers abstracts and full-text articles by [Yibin Xiang, Bradford Hirth, Gary Asmussen, Hans-Peter Biemann, Kimberly A Bishop, Andrew Good, Maria Fitzgerald, Tatiana Gladysheva, Annuradha Jain, Katherine Jancsics, Jinyu Liu, Markus Metz, Andrew Papoulis, Renato Skerlj, J David Stepp, Ronnie R Wei].
I knew an old boy who mounted a barrel behind the axle on his old Farmall so he could take his kid to the field with him and not worry about losing him to a tragic run-over accident. I bet he knew someone who lost a child that way. When riding the fender, axle, or a parents lap, a kid can fall forward and be run over by the rear wheel of a tractor. It does happen! Passengers should not be riding on tractors unless modifiations are added to make it safe. Families never really recover from tragedies that kill their kids, and the emergency personnel that have to clean up the aftermath carry those images in their heads, too. Kids are precious, and cant be replaced, so dont do what this guy is doing, and that goes for your riding lawnmower, too ...
May and friends are walking through the woods when they find a wounded Swablu. Swablu puts the kids to sleep with Sing, but Torchic wakes them up by pecking their noses.
The Yankees have decided, as expected, to start the ALDS on Wednesday instead of Thursday to get the day of rest between Game 1 and 2.. As for the rotation, it will be CC Sabathia in Game 1 followed by A.J. Burnett and Andy Pettitte. Thats a little bit of a surprise considering Burnett would get the nod for Game 5 instead of Pettitte who has always been a big-game pitcher for the Yankees.. However, Burnett is pretty comfortable at home and Pettitte doesnt get rattled on the road.. ...
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The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
Epidural fibrosis (EF) is a common complication after laminectomy. Salvianolic acid B (Sal B) is a major bioactive component of a traditional Chinese medical agent, Salvia miltiorrhiza, which has shown anti-inflammatory, anti-fibrotic and anti-proliferative properties. The object of this study was to investigate the effect of Sal B on the prevention of epidural fibrosis in laminectomy rats. A controlled double-blinded study was conducted in sixty healthy adult Wistar rats that underwent laminectomy at the L1-L2 levels. The rats were randomly divided into 3 groups of 20: (1) Sal B treatment group; (2) Vehicle group; (3) Sham group (laminectomy without treatment). All rats were sacrificed 4 weeks post-operatively. The extent of epidural fibrosis, fibroblast proliferation and the expression of vascular endothelial growth factor (VEGF) and inflammatory factors were analyzed. The recovery of all rats was uneventful. In the laminectomy sites treated with Sal B, the dura mater showed no adhesion. Collagen
Danshensu (DSU) and salvianolic acid B (SAB) are the primary water-soluble compounds of Salvia miltiorrhiza Bunge (Lamiaceae). In this study, we analyzed the effects of DSU, SAB and a S. miltiorrhiza extract (SME) on cell proliferation. Additionally, the effects of DSU and SAB on collagen synthesis in Detroit 551 human normal fibroblast cells and on melanin production in B16 melanoma cells were verified. The results demonstrated that SME can enhance the proliferation of Detroit 551 cells and that this boost may be caused by DSU and SAB. This research showed that SME, DSU and SAB all have the ability to increase the production of collagen in Detroit 551 cells. The results also confirmed that DSU and SAB can attenuate the α-MSH-stimulated melanin production of B16 cells by inhibiting tyrosinase activity. Therefore, SME, DSU and SAB each have the potential to be utilized as active ingredients in wound healing or cosmetic treatments. In the future, DSU and SAB could also be used as functional components
Salvianolic acid B (Sal B), an antioxidant and free radical scavenging compound, is the most abundant bioactive compound extracted from the root of Salvia miltiorrhiza Bunge.
Usnic acid is a dibenzo-furandione which is uniquely found in lichen (Usnea) species, which are distributed worldwide. In vitro usnic acid has antibacterial, antifungal and antiviral activities, and lichen extracts containing usnic acid have been used in folk medicine externally for wound healing and athletes foot and internally for sore throat, toothache and fever. Usnic acid has also found several commercial uses, largely in perfumery and cosmetic products, but also in medicinal creams. However, usnic acid appears to be toxic when taken orally in high doses and, for instance, can cause ataxia and paralysis in animals grazing on lichen contaminated crops and grains. Usnic acid has been purified and extensively studied in vitro and has been shown to uncouple oxidative phosphorylation in isolated mitochondria, which may account for its broad antimicrobial activity. Uncoupling of oxidative phosphorylation by decreasing the efficacy of energy use and causing increased thermogenesis has been ...
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ABSTRACTThe annual variations of wet deposition of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) in atmosphere were measured at two sites (A and B) near two municipal solid waste incinerators (MSWIs) in southern Taiwan. Results showed that particle scavenging dominates in the wet deposition processes for the removal of PCDD/Fs from the atmosphere, the highest value was observed at the highest chlorinated congener. The ambient temperature and the amount of precipitation played an important role in the variation of PCDD/F deposition fluxes. It was found that temperature was inversely associated with the existence of particulate PCDD/Fs, indicating PCDD/Fs are scavenged most efficiently in cold weather. PCDD/F wet deposition fluxes in rainy seasons (from June to August) were significantly higher than those in dry seasons (from December to February), revealing a positive relationship between wet deposition flux and monthly rainfall. Additionally, the annual total (dry + wet) deposition
Results of recent studies showed that 2,3,4,7,8-pentachlorodibenzofuran (PeCDF) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are equipotent in domestic chicken (Gallus gallus domesticus) while PeCDF is more potent than TCDD in ring-necked pheasant (Phasianus colchicus) and Japanese quail (Coturnix japonica). To elucidate the mechanism(s) underlying these differences in relative potency of PeCDF among avian species, we tested the hypothesis that this is due to species-specific differential binding affinity of PeCDF to the aryl hydrocarbon receptor 1 (AHR1). Here, we modified a cell-based binding assay that allowed us to measure the binding affinity of dioxin-like compounds (DLCs) to avian AHR1 expressed in COS-7 (fibroblast-like cells). The results of the binding assay show that PeCDF and TCDD bind with equal affinity to chicken AHR1, but PeCDF binds with greater affinity than TCDD to pheasant (3-fold) and Japanese quail (5-fold) AHR1. The current report introduces a COS-7 whole-cell binding ...
In vitro analysis of polychlorinated biphenyls (PCBs) and 2,3,4,7,8-pentachlorodibenzofuran (PCDF) cellular toxicity in PLC/PRF/5 cell proliferation--the effect of ursodeoxycholic acid, inchin-gorei-san and shou-saiko-to on cell toxicity.
Mass spectrometry/mass spectrometry (MS/MS) has been shown to be useful in the analysis of environmental samples for low (ppt) levels of compounds like polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) in cases where interfering materials present in the samples made analysis by high resolution mass spectrometry (HRMS) difficult or impossible. While the technique shows promise because of its high selectivity, researchers have reported stability problems with mass spectrometry/mass spectrometry instruments and other questions regarding the reproducibility of analytical results exist. This study was undertaken to develop an MS/MS method for the analysis of PCDD/Fs, determine the stability of an MS/MS instrument over a period of months and to compare analytical results obtained by MS/MS with those obtained by HRMS. The results demonstrated that by following the protocol developed in the study, an MS/MS instrument can generate reproducible analytical results over a period of months and ...
Title: Dronedarone: A Safety Comparison to Amiodarone. VOLUME: 5 ISSUE: 3. Author(s):James R. Clem, Debra K. Farver, Janet R. Fischer and Thomas J. Johnson. Affiliation:South Dakota State University College of Pharmacy, 4801 North Career Avenue, Sioux Falls, SD 57107, USA.. Keywords:Dronedarone, SR 33589, amiodarone, atrial fibrillation, safety. Abstract: Dronedarone is an oral Class III antiarrhythmic agent which was recently approved by the US Food and Drug Administration for use in nonpermanent atrial fibrillation. Structurally similar to amiodarone, dronedarone is a benzofuran derivative but it lacks the iodine moiety attached to amiodarone. Based upon the investigational clinical trials to date, it appears that dronedarone has an established efficacy when compared to placebo along with exhibiting a minimal adverse effect profile. The efficacy of dronedarone will need to be further evaluated in comparison trials with established antiarrhythmics for atrial fibrillation. The adverse profile of ...
NTP MEAN BODY WEIGHTS AND SURVIVAL TABLE REPORT: EISRPT41 LAB: Battelle Columbus TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) DATE: 07/14/03 EXPERIMENT: 96007 TEST: 05 TIME: 14:21:29 CAGES FROM 0000 TO LAST CAGE PAGE: 1 TEST TYPE: CHRONIC ROUTE: GAVAGE NTP: C96007F ------------------------------------------------------------------------------------------------------------------------------------ REASONS FOR REMOVAL: ALL REMOVAL DATE RANGE: ALL TREATMENT GROUPS: INCLUDE ALL NTP MEAN BODY WEIGHTS AND SURVIVAL TABLE REPORT: EISRPT41 LAB: BATTELLE COLUMBUS TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) DATE: 07/14/03 EXPERIMENT: 96007 TEST: 05 TIME: 14:35:48 SPECIES: RATS, SPRAGUE-DAWLEY TEST TYPE: TWO YEAR ROUTE: ORAL GAVAGE NTP: 96007F CONT: NO1-ES-75411 CAS: 57117-31-4 MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE RATS IN THE TWO YEAR ORAL GAVAGE STUDY OF TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) ...
Other data set: Additional PCB congeners are reported under data file name PCBPOL_F. Among these PCB congeners PCB 105, 114, 118, 156, 157, 167 and 189 has a toxic equivalence factor (TEF) and may be used with this data set for calculating a total TCDD equivalence.. Subsample Weights. PCDDs, PCDFs, and cPCBs were measured in a one-third subsample of participants 12 years and older. Special sample weights are required to analyze these data properly. Specific sample weights for this subsample are included in this data file and should be used when analyzing these data.. Samples were pooled in groups of 8 samples per pool within 40 demographic groups. The analysis of NHANES 2009-2010 pooled-sample data must be conducted with the basic demographic variables provided in this data file. This pooled-sample data file cannot be linked to other NHANES 2009-2010 data. Because each sample person does not have an equal probability of selection, sample weighting is needed to produce correct population ...
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The Minnesota Department of Health (MDH) has prepared this memo in response to your January 28, 2003, request for guidance on dioxin, as well as to identify a consistent approach for agencies and programs to assess the carcinogenic health risks from exposure to dioxin-like compounds. Guidance for assessing the noncancer health risks is still under development and will not be addressed in this memo. Because of the uncertainties associated with the toxicities of dioxin mixtures, MDH uses a conservative approach to evaluate potential risks. As more data become available, MDH re-evaluates and revises its risk assessment methods and procedures, as appropriate. Dioxin-like Compounds. The term dioxins is used to refer to a family of complex but related chlorinated compounds with similar chemical structures and biological activity. The polychlorinated dibenzo-p-dioxins (PCDDs) include 75 individual compounds, the polychlorinated dibenzofurans (PCDFs) include 135 individual compounds, and the ...
Provides information to potential participants on the following clinical trial: Phase I Dose-Escalation Study of Brutons Tyrosine Kinase (Btk) Inhibitor PCI-32765 in Recurrent B Cell Lymphoma
Usnic acid, a lichen secondary metabolite inhibits Group A Streptococcus biofilms.: Group A Streptococci (GAS) are involved in a number of life threatening dise
Breast cancer is the most common cancer types among women. Recent researches have focused on determining the efficiency of alternative molecules and miRNAs in breast cancer treatment. The aim of this study was to determine the effect of usnic acid response-miR-185-5p on proliferation in the breast cancer cell and to determine its relationship with apoptosis pathway. The cell proliferation and cell apoptosis rate were significantly increased following the ectopic expression of miR-185-5p in BT-474 cells. Furthermore, the results of cell cycle assay performed by flow cytometry revealed that the transfection with miR-185-5p induced G1/S phase arrest. The apoptosis-related genes expression analysis was performed by qRT-PCR and the direct target of miR-185-5p in BT-474 cells was identified by western blot and luciferase reporter assay. Our data showed that miR-185-5p can cause significant changes in apoptosis-related genes expression levels, suggesting that cell proliferation was suppressed by miR-185-5p via
NTP Experiment-Test: 96007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) Date: 07/14/03 Route: GAVAGE Time: 14:46:46 31 WEEK SSAC RATS Facility: Battelle Columbus Laboratory Chemical CAS #: 57117-31-4 Lock Date: 07/25/02 Cage Range: All Reasons For Removal: 25017 Scheduled Sacrifice Removal Date Range: 11/03/99 - 11/04/99 Treatment Groups: Include All Note: Animals arranged according to CID number Page 1 NTP Experiment-Test: 96007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) Date: 07/14/03 Route: GAVAGE Time: 14:46:46 __________________________________________________________________________________________________________________________________ , 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, , , DAY ON TEST , 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, , , , 2, 1, 1, 1, 1, 1, 2, 2, 2, 2, 1, 1, 1, 1, 1, 2, , , ...
High levels of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/Fs) in edible fish in the Baltic Sea have raised health concerns in the Baltic region and the rest of Europe. Thus, there are urgent needs to characterize sources in order to formulate effective mitigation strategies. The aim of this thesis is to contribute to a better understanding of past and present sources of PCDD/Fs in the Baltic Sea environment by exploring chemical fingerprints in sediments, air, and biota. The spatial and temporal patterns of PCDD/F distributions in the Baltic Sea during the 20th century were studied in Swedish coastal and offshore sediment cores. The results showed that PCDD/F levels peaked in 1975 (± 7 years) in coastal and 1991 (± 5 years) in offshore areas. The time trends of PCDD/Fs in the sediment cores also showed that environmental half-lives of these pollutants have been shorter in coastal than in offshore areas (15 ± 5 and 29 ± 14 years, respectively). Consequently, ...
Title:Novel Benzo[B]Furans with Anti-Microtubule Activity Upregulate Expression of Apoptotic Genes and Arrest Leukemia Cells in G2/M Phase. VOLUME: 19 ISSUE: 3. Author(s):Karolina Królewska-Golińska, Marcin J. Cieślak*, Milena Sobczak, Rafał Dolot, Ewa Radzikowska-Cieciura, Mariola Napiórkowska, Iwona Wybrańska and Barbara Nawrot. Affiliation:Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, 112 Sienkiewicza Str., 90-363 Lodz, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, 112 Sienkiewicza Str., 90-363 Lodz, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, 112 Sienkiewicza Str., 90-363 Lodz, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, 112 Sienkiewicza Str., 90-363 Lodz, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, 112 Sienkiewicza Str., 90-363 Lodz, Department of Medical Chemistry, Medical University of Warsaw, 3 Oczki Str., 02-007 Warsaw, ...
Salvianolic acid B inhibits growth of head and neck squamous cell carcinoma in vitro and in vivovia cyclooxygenase-2 and apoptotic pathways. International Journal of Cancer. Vol.124, No.9 (1 May 2009): 2200-2209. Yubin Hao, Tianpei Xie, Alexandru Korotcov, Yanfei Zhou, Xiaowu Pang, Liang Shan, Hongguang Ji, Rajagopalan Sridhar, Paul Wang, Joseph Califano, Xinbin Gu.. ...
Salvianolic acid B inhibits growth of head and neck squamous cell carcinoma in vitro and in vivovia cyclooxygenase-2 and apoptotic pathways. International Journal of Cancer. Vol.124, No.9 (1 May 2009): 2200-2209. Yubin Hao, Tianpei Xie, Alexandru Korotcov, Yanfei Zhou, Xiaowu Pang, Liang Shan, Hongguang Ji, Rajagopalan Sridhar, Paul Wang, Joseph Califano, Xinbin Gu.. ...
The main air pollutants in the sintering process of iron ore are polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans (PCDD/Fs) and harmful dust. Ore sintering on sinter strands is one of the first technology steps in the ironworks. It is a process in which iron ore is crushed, subjected to annealing and mixed with appropriate additives, and then sintered in order to produce sinter which is the main component of iron in the blast furnace process. PCDD/Fs emissions were measured and the addition of ammonium sulfate as an inhibitor of the synthesis of dioxins in the sintering process of iron ore was studied ...
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Yusho Disease is a condition caused by poisoning with polychlorinated biphenyls (PCBs) and polychlorinated dibenzofurans (PCDFs). This primarily refers to a specific mass poisoning with PCBs and PCDFs in rice bran oil, which occurred in northern Kyushu, Japan, in 1968. About 14,000 people who had consumed the contaminated rice oil in Japan were affected. Common symptoms included some abnormalities on the skin and eye tissues, irregular menstrual cycles and a lowered immune system. Other symptoms included fatigue, headache, cough, and unusual skin sores. Additionally, in children, there were reports of poor cognitive development.. An almost identical case occurred in Taiwan a decade later in 1979, known as Yu-cheng disease.. ...
Prucalopride is an orally active enterokinetic compound that has been launched as a therapy for laxative-resistant chronic constipation. Prucalopride acts
Single-centre, double-blind, placebo-controlled, cross-over study in 33 healthy volunteers with 2 sessions. Each session consisted of a run-in day for baseline assessments, 8 treatment days and 5 additional days for followup assessments. Subjects were randomised to start with either the prucalopride or placebo session. The prucalopride dose was consecutively escalated in 2 mg steps per day, starting from 2 mg up to 10 mg once daily If a subject did not tolerate the 10- or 8-mg dose, 1 step back in the dosage scheme was allowed, from 10 to 8 mg on Day 6, or from 8 to 6 mg on Day 5. Subjects with intolerance for doses of less than 6 mg, were withdrawn from the study. Repeated dosing (6, 8 or 10 mg) was continued once daily until Day 8, to achieve steady-state. During placebo, the number of placebo tablets was consecutively escalated in an identical way as described for prucalopride. Between the 2 sessions, there was a washout period of 14 to 21 days, to avoid any carry-over effect ...
Kombucha contains multiple species of yeast and bacteria, along with the amino acids, enzymes, organic acids and polyphenols they produce.. It is also rich in B-complex vitamins and vitamin C (about 750mg per 500ml - the exact quantities vary between samples.). The chance of contamination by airborne moulds or bacterial spores is very low because of the mild alcoholic element (less than 0.5%) and its acidity; acetic acid, ethanol, gluconic acid, glucuronic acid, glycerol, lactic acid and usnic acid. Usnic acid possesses a wide range of intersecting biological properties.. It has been shown to have potent antibiotic effective against harmful bacteria, such as E. Coli, Staphylococcus, Streptococcus and Pneumococcus ...
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3H-Spiro[1-benzofuran-2,4-piperidine]/ACM71916739 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
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Before hiring a company, ask them the process they use to clean carpets. You should hear that they begin with vacuuming before they start deep cleaning. The carpet is going to look much better when done, so if the cleaner refuses to vacuum, find another company.. While a carpet cleaner may not restore your carpet to its original glory, theres a good chance that it can come close. Keep these tips in mind when calling companies to help you determine the right carpet cleaner. Youll have great looking carpet again in no time by following the advice you learned in this article.. Carpet Cleaning. #carpetcleaningsydney #carpetcleaning #floodrestorationsydney. Contact Us:. True Blue Carpet ...
Previous investigations suggest that DL-3-n-butylphthalide (NBP) is a promising multifaceted drug for the treatment of stroke. It is not clear whether NBP can treat traumatic brain injury (TBI) and what could be the mechanisms of therapeutic benefits. To address these issues, TBI was induced by a controlled cortical impact in adult male mice. NBP (100 mg/kg) or saline was intraperitoneally administered within 5 min after TBI. One day after TBI, apoptotic events including caspase-3/9 activation, cytochrome c release from the mitochondria, and apoptosis-inducing factor (AIF) translocation into the nucleus in the pericontusion region were attenuated in NBP-treated mice compared to TBI-saline controls. In the assessment of the nuclear factor kappa-light-chain-enhancer of activated B (NF-κB) pathway, NBP ameliorated the p65 expression and the p-IκB-α/IκB-α ratio, indicating reduced NF-κB activation. Consistently, NBP reduced the upregulation of proinflammatory cytokines such as tumor ...
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Italy and #OperationGreenRights are still working on the data, about the chemical agents, contained in the dumps of Ilvas and Riva Groups database (www.ilvataranto.com & www.rivagroup.com). The chemical agents tables, sometimes, are not easy to read, sometimes is not possible to understand which is the real grade of production, of these materials, but is sure that some values are not crossable. Another certain is that these limits are applied by the law. The factories, which produce chemical agents over the limits set by the law, make this work dangerous for all the people who works in these places and for who lives in these cities. The limits are decided by the law, so are not changeable by the owners of these factories. One of the most dangerous chemical agent produced is furan (C4H4O). The furan is an organic persistent enviromental pollutant which naturally becames benzofuran polychlorinated, whom is associated to dioxins. Also normally, the furan is highly volatile close to room ...
Even though heterogeneities of epithelial and mesenchymal-transitioned cancer cells are often observed within the tumor microenvironment the biological significance of the interaction between epithelial cancer cells and mesenchymal-transitioned cancer cells Salvianolic acid A is not yet understood. mean luminescence?±?SEM. Microarray data analysis The datasets (type:entrez-geo attrs :text:GSE17708″ term_id :17708″GSE17708 and type:entrez-geo attrs :text:GSE23952″ term_id :23952″GSE23952) […]. ...
ABSTRACT: A new multispored species of Lecanora containing usnic acid, L. weii is described as new to science. A key to the four known multispored speciesof Lecanora in China is also provided. KEYWORDS: Ascomycota, flora of China, lichens, pruinose discs ...
Moura, Jusci ne B. et al. In vitro antimicrobial activity of the organic extract of Cladonia substellata Vainio and usnic acid against Staphylococcus spp. obtained from cats and dogs. Pesq. Vet. Bras., Apr 2017, vol.37, no.4, p.368-378. ISSN 0100- ...
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Faizi, Darius (2016). "Oxyboration: Synthesis of Borylated Benzofurans". Organic Syntheses. 93: 228-244. doi:10.15227/orgsyn. ...
... (abbreviation of "5-(2-aminopropyl)benzofuran"; see infobox for the correct IUPAC name) is an empathogenic psychoactive ... Rickli A, Kopf S, Hoener MC, Liechti ME (July 2015). "Pharmacological profile of novel psychoactive benzofurans". British ... 2014 the UK Home Office announced that 6-APB would be made a class B drug on 10 June 2014 alongside every other benzofuran ... benzofuran (5-APB) intoxication and fatality: a case report with postmortem concentrations". Journal of Analytical Toxicology. ...
... (6-(2-aminopropyl)benzofuran) is an empathogenic psychoactive compound of the substituted benzofuran and substituted ... 4-bromo-1-benzofuran and 6-bromo-1-benzofuran. The isomers were separated by silica gel column chromatography, then converted ... 4-methylenedioxyphenyl ring system has been replaced with a benzofuran ring. 6-APB is also the unsaturated benzofuran ... The study also noted how, unlike the MDMA it often serves as a replacement for in countries like the US, 6-APB's benzofuran ...
Monte AP, Marona-Lewicka D, Cozzi NV, Nichols DE (November 1993). "Synthesis and pharmacological examination of benzofuran, ... "Pharmacological profile of novel psychoactive benzofurans". British Journal of Pharmacology. 172 (13): 3412-25. doi:10.1111/bph ...
A variety of substituted aromatic rings can be prepared using this method including: phenols, naphthalenes, benzofurans, ... This also includes napthalenes, benzofurans and indoles. This second generation aromatic annulation is achieved by irradiation ...
The asymmetric hydrogenation of furans and benzofurans has so far proven challenging. Some Ru-NHC complex catalyze asymmetric ... The asymmetric hydrogenation of furans and benzofurans As is the case with oxygen-containing heterocycles, the asymmetric ... "Ruthenium NHC Catalyzed Highly Asymmetric Hydrogenation of Benzofurans". Angewandte Chemie International Edition. 51 (7): 1710- ... hydrogenations of benzofurans and furans. with high levels of enantioinduction. ...
... (1-(benzofuran-6-yl)-N-ethylpropan-2-amine) is a potentially psychedelic and potentially entactogenic drug of the ... The ACMD has advised that 6-EAPB (and other benzofurans) are moved to Class B, this came into action on 10 June 2014. Taschwer ... "Ban on NBOMe and benzofurans comes into force". Retrieved 15 June 2015. v t e. ... benzofuran class; it is structurally related to 6-APB and MDMA. As an N-ethyl derivative of 6-APB, 6-EAPB fell outside the ...
It is isomeric with benzofuran. Isobenzofuran is highly reactive and rapidly polymerizes; however, it has been identified and ...
"The Characterization of 2-(5-Methoxy-1-benzofuran-3-yl)-N,N-dimethylethanamine (5-MeO-BFE) and Differentiation from its N-Ethyl ... Tomaszewski Z, Johnson MP, Huang X, Nichols DE (May 1992). "Benzofuran bioisosteres of hallucinogenic tryptamines". Journal of ... making 5-MeO-DiBF a benzofuran derivative. It is several times less potent as a serotonin agonist than 5-MeO-DiPT and with ...
Xie, WD, Gao, X., Shen, T., Jia, ZJ (2006). Two new benzofurans and other constituents from Ligularia przewalskii. Pharmazie 61 ...
Kim, Soyoung; Salim, Angela; Swanson, Steven; Douglas Kinghorn, A. (2006-07-01). "Potential of Cyclopenta[b]benzofurans from ... benzofurans fromAglaiaSpecies1". Journal of Natural Products. 61 (12): 1482-1490. doi:10.1021/np9801965. ISSN 0163-3864. PMID ...
Part 1: indole and benzofuran derivatives". Bioorganic & Medicinal Chemistry Letters. 12 (10): 1399-404. doi:10.1016/S0960-894X ...
8,5'-DiFA (BF) is the benzofuran form. Ferulic acid can also form trimers and tetramers, known as triferulic and tetraferulic ...
The unsaturated benzofuran derivative 6-APB, or 6-(2-aminopropyl)benzofuran is also known, but the difference in ... It is banned by a blanket law on benzofurans and related compounds. Monte AP, Marona-Lewicka D, Cozzi NV, Nichols DE (November ... 1993). "Synthesis and pharmacological examination of benzofuran, indan, and tetralin analogues of 3,4-(methylenedioxy) ...
Kim SI, Park IH, Song KS (2002). "kynapcin-13 and -28, new benzofuran prolyl endopeptidase inhibitors from Polyozellus ... Song KS, Raskin I (2002). "A prolyl endopeptidase-inhibiting benzofuran dimer from Polyozellus multiflex". Journal of Natural ...
June 2001). "(-)-1-(Benzofuran-2-yl)-2-propylaminopentane enhances locomotor activity in rats due to its ability to induce ... Magyar K, Lengyel J, Bolehovszky A, Knoll B, Miklya I, Knoll J (2002). "The fate of (-)1-(benzofuran-2-yl)-2-propylaminopentane ... benzofuran-2-yl)-2-propylaminopentane". European Journal of Pharmacology. 482 (1-3): 9-16. doi:10.1016/j.ejphar.2003.09.044. ... benzofuran-2-yl)-2-propylaminopentane". Progress in Neuro-Psychopharmacology & Biological Psychiatry. 30 (1): 5-14. doi:10.1016 ...
The full name of the chemical is 2-(8-bromo-2,3,6,7-tetrahydrofuro[2,3-f] [1]benzofuran-4-yl)ethanamine. It has been subject to ... June 2008). ""Hybrid" Benzofuran-Benzopyran Congeners as Rigid Analogues of Hallucinogenic Phenethylamines". Bioorganic & ... 25B-NMe7BF 25B-NMe7BT 25B-NMe7Box 25B-NMe7DHBF 25B-NMe7Ind 25B-NMe7Indz 25B-NMePyr Substituted benzofurans: 2C-B-FLY 2CBFly- ...
... benzofuran from Aglaia elliptifolia". Chem Commun. 1992: 1150-51. Ebada, S. S.; Lajkiewicz, N.; Porco, J. A.; Jr; Li-Weber, M ... benzofuran skeleton. In 1982 King and colleagues discovered the first member of this family, rocaglamide, based on its ...
Schultz DM, Prescher JA, Kidd S, Marona-Lewicka D, Nichols DE, Monte A (June 2008). "'Hybrid' benzofuran-benzopyran congeners ... 25B-NMe7BF 25B-NMe7BT 25B-NMe7Box 25B-NMe7DHBF 25B-NMe7Ind 25B-NMe7Indz 25B-NMePyr Substituted benzofurans: 2C-B-FLY 2CBFly- ...
Resins derived from Coumarone (Benzofuran) and indene are also produced. Ketjen, founded by Gerhard Tileman Ketjen; one of the ...
F-22 (psychedelic) Substituted benzofuran Shulgin A, Shulgin A (September 1991). PiHKAL: A Chemical Love Story. Berkeley, ...
... benzopyrans and benzofurans. Extracts of the plant have shown antifungal, anticyanobacterial, and antitermite effects. A number ...
... substituted cathinones and benzofurans at biogenic amine transporters". Psychopharmacology. 236 (3): 939-952. doi:10.1007/ ... substituted cathinones and benzofurans at biogenic amine transporters". Psychopharmacology. 236 (3): 939-952. doi:10.1007/ ...
... substituted cathinones and benzofurans at biogenic amine transporters". Psychopharmacology. 236 (3): 939-952. doi:10.1007/ ...
... aryl-benzofurans, and neoflavonoids. Ziteng was first described in 304 AD in a book on plants, Nanfang Caomu Zhuang (Plants of ...
It is also known as isocoumaran, or 1,3-dihydro-2-benzofuran. One of derivatives of it is Citalopram. It can be oxidised to ...
... dronedarone is a benzofuran derivative related to amiodarone, a popular antiarrhythmic. The use of amiodarone is limited by ... a noniodinated benzofuran derivative, in the rabbit heart : comparison with amiodarone". Circulation. 100 (22): 2276-81. doi: ...
The first step in this reaction to the substituted benzofuran is called the Rap-Stoermer condensation after E. Rap (1895) and R ... Etherification with chloroacetic acid followed by cyclisation gives the heterocycle benzofuran (coumarone). { ...
Kim SI, Park IH, Song KS (2002). "kynapcin-13 and -28, new benzofuran prolyl endopeptidase inhibitors from Polyozellus ...
Benzofuran reacts preferentially in the furan ring rather than in the benzene ring. However, the 7-hydroxy derivative of 2,3- ...
Benzofuran is extracted from coal tar. It is also obtained by dehydrogenation of 2-ethylphenol. Benzofurans can be prepared by ... Benzofuran is the "parent" of many related compounds with more complex structures. For example, psoralen is a benzofuran ... Benzofuran is the heterocyclic compound consisting of fused benzene and furan rings. This colourless liquid is a component of ... Aurone Thunberginol F Benzofuran Schiff base "Front Matter". Nomenclature of Organic Chemistry : IUPAC Recommendations and ...
The substituted benzofurans are a class of chemical compounds based on the heterocyclyc and polycyclic compound benzofuran. ... Many medicines use the benzofuran core as a scaffold, but most commonly the term is used to refer to the simpler compounds in ... In general, these compounds have a benzofuran core to which a 2-aminoethyl group is attached (at any position), and combined ... The derivatives may be produced by substitutions at six locations of the benzofuran molecule, as well as saturation of the 2,3 ...
... and application of furans and benzofurans bearing a fluorine atom and a trifluoromethyl group are reviewed. ... Zhou H, Niu J-J, Xu J-W, Hu S-J (2009) Novel route to 2-trifluoromethylated benzofurans. Synth Commun 39:716-732CrossRefGoogle ... Synthesis and reactions of (trifluoromethyl)benzofurans. Chem Pharm Bull 25:3009-3012CrossRefGoogle Scholar ... Butin A.V., Trushkov I.V., Serdyuk O.V., Abaev V.T. (2014) Fluorinated Furans and Benzofurans. In: Nenajdenko V. (eds) Fluorine ...
Animal studies have shown effects on the liver, kidneys, lungs, and stomach from exposure to high levels of 2,3-benzofuran. ... 3-benzofuran is most likely to occur from breathing contaminated air at the workplace. ... 2,3-Benzofuran is not used for any commercial purposes, but the part of the coal oil that contains 2,3-benzofuran is made into ... Is there a medical test to show whether Ive been exposed to 2,3-benzofuran?. There is a test to measure 2,3-benzofuran in the ...
The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects information for the hazardous substance described here. Each peer-reviewed profile identifies and reviews the key literature that describes a hazardous substances toxicologic properties. Other pertinent literature is also presented, but is described in less detail than the key studies. The complete list of topics covered (chapter titles) is shown at the left and in more detail further down this page.
Benzofuran derviatives have shown biological activities ranging from antifungal and antimicrobial to antagonists for the H3 ... A diversity of synthetic routes can be applied to the synthesis of benzofurans. The presence of a halogen allows these reagents ... Lear More about Benzofurans
New Reagents for ... Benzofuran (coumarone), a heterocyclic compound consisting of fused benzene and furan rings, has been identified as a ...
See Also: Toxicological Abbreviations Benzofuran (IARC Summary & Evaluation, Volume 63, 1995) ...
benzofuran synonyms, benzofuran pronunciation, benzofuran translation, English dictionary definition of benzofuran. n. A ... benzofuran. Also found in: Thesaurus, Encyclopedia, Wikipedia.. Related to benzofuran: Benzothiophene ben·zo·fu·ran. (bĕn′zō- ... Benzofuran - definition of benzofuran by The Free Dictionary https://www.thefreedictionary.com/benzofuran ... benzofuran. (ˌbɛnzəʊˈfjʊəræn) n. (Elements & Compounds) a colourless insoluble aromatic liquid obtained from coal tar and used ...
... benzofurans. The synthetic utility is demonstrated by the short synthesis of natural benzofurans without protection of the ... Synthesis of Benzofurans. Recent Literature. A convenient metal-free cyclization of ortho-hydroxystilbenes into 2- ... A one-pot method for the preparation of alkyl aryl ethers from aryl halides and the preparation of substituted benzofurans via ... Moreover, the O-arylated products so formed can be directly transformed into substituted benzofurans in a single operation.. T ...
3-Benzofuran 0.99; CAS No.: 271-89-6; Synonyms: Coumarone; Linear Formula: C8H6O; Empirical Formula: C8H6O; find related ...
The WHO Regional Office for Europe (‎EURO)‎ and the WHO European Centre for Environment and Health, Bilthoven Division have coordinated a comprehensive programme on polychlorinated biphenyls (‎PCBs)‎, polychlorinated ...
2,3-Benzofuran. SUMMARY. What is 2,3-benzofuran?. What happens to 2,3-benzofuran when it enters the environment?. How might I ... How can 2,3-benzofuran affect my health?. How likely is 2,3-benzofuran to cause cancer?. Is there a medical test to show ... 2,3-Benzofuran is not used for any commercial purposes. Rather, the part of the coal oil that contains 2,3-benzofuran is made ... Is there a medical test to show whether Ive been exposed to 2,3-benzofuran?. There is a test to measure 2,3-benzofuran in the ...
The WHO Regional Office for Europe (‎EURO)‎ and the WHO European Centre for Environment and Health, Bilthoven Division have coordinated a comprehensive programme on polychlorinated biphenyls (‎PCBs)‎, polychlorinated ...
3-Dimethyl-1-benzofuran-5-amine , C10H11NO , CID 12445383 - structure, chemical names, physical and chemical properties, ...
The benzofuran 15a could be obtained by using ethyl iodoacetate (14) as a C1-unit. The one-pot conversion of dihydrobenzofurans ... The direct synthesis of benzofuran 15b was achieved by using the active methine 18 having ketone and ester groups. ... 7a, 7b and 8a into benzofurans 15a and 15b was also studied. ... The benzofuran 15a could be obtained by using ethyl iodoacetate ... The one-pot conversion of dihydrobenzofurans 7a, 7b and 8a into benzofurans 15a and 15b was also studied. The direct synthesis ...
3,6-dimethyl-2,3-dihydro-1-benzofuran-2-one EC Name:. -. CAS Number:. 65817-24-5 IUPAC Name:. 3,6-dimethyl-2,3-dihydro-1- ...
Parallel Synthesis of Benzofurans. 12 February 2015 A series of benzofurans (structures often targeted in diabetes and insulin ... Starting out with p-hydroxybenzaldehyde, a four step synthetic pathway led to the synthesis of a benzofuran derivative in high ...
A new series of 2-alkyloxy-pyridine-3-carbonitrile-benzofuran hybrids (4a-x) was synthesized. All the new derivatives were ... 2-Acetylbenzofuran [38], 3-(benzofuran-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde (1) [32] and 2-((3-(benzofuran-2-yl)-1-phenyl- ... Synthesis and 2D-QSAR Study of Active Benzofuran-Based Vasodilators. Nagy M. Khalifa 1,2. , Aladdin M. Srour 2,*,†, Somaia S. ... 4-(3-(Benzofuran-2-yl)-1-phenyl-1H-pyrazol-4-yl)-2-ethoxy-6-(furan-2-yl)pyridine-3-carbonitrile (4r): Yield 2.14 g (45.3%), m.p ...
2-benzofuran-1,3-dione, addition product with 2-(2-hydroxyethoxy)ethanol, reacted with one mole ethylene oxidebenzofuran-1,3-dione, addition product with 2-(2-hydroxyethoxy)ethanol, reacted with two mole ethylene oxidebenzofuran-1,3-dione, addition product with 2-(2-hydroxyethoxy)ethanol, reacted with three mole ethylene oxidebenzofuran-1,3-dione, addition product with 2-(2-hydroxyethoxy)ethanol, reacted with one mole ethylene oxide
2-benzofuran-1,3-dione, addition product with 2-(2-hydroxyethoxy)ethanol, ethoxylated. ...
5,5-sulfonylbis(2-benzofuran-1,3-dione). CAS names 1 IUPAC names 2 Other identifiers 3 ...
5-Butyl-7-methoxy-1-benzofuran-4-yl) acetate , C15H18O4 , CID 188490 - structure, chemical names, physical and chemical ...
Benzofurans used to inhibit bone loss EP19960300344 EP0722726A1 (en) 1995-01-20. 1996-01-17. Benzofuran derivatives for ... Benzofurans as suppressors of neurodegeneration JP4761112B2 (en) * 2005-02-16. 2011-08-31. 公益財団法人新産業創造研究機構. Comprising a ... Benzofurans used to inhibit bone loss Applications Claiming Priority (4). Application Number. Priority Date. Filing Date. Title ... Benzofurans used to inhibit bone loss Download PDF Info. Publication number. US5489587A. US5489587A US08376955 US37695595A
benzofurans, C-H activation, deuterium, palladium, synthetic methods National Category Organic Chemistry Identifiers. URN: urn: ... Palladium-Catalyzed Synthesis of 2,3-Disubstituted Benzofurans: An Approach Towards the Synthesis of Deuterium Labeled ... Palladium-catalyzed oxidative annulations between phenols and alkenylcarboxylic acids produced a library of benzofuran ...
benzofurans, C-H activation, deuterium, palladium, synthetic methods HSV kategori Identifikatorer. URN: urn:nbn:se:su:diva- ... Palladium-Catalyzed Synthesis of 2,3-Disubstituted Benzofurans: An Approach Towards the Synthesis of Deuterium Labeled ... Palladium-catalyzed oxidative annulations between phenols and alkenylcarboxylic acids produced a library of benzofuran ...
A new palladium-catalyzed method for the synthesis of benzofurans by reaction of 2-hydroxystyrenes and iodobenzenes via a C-H ... A new palladium-catalyzed method for the synthesis of benzofurans by reaction of 2-hydroxystyrenes and iodobenzenes via a C-H ... Palladium-catalyzed synthesis of benzofurans via C-H activation/oxidation tandem reaction and its application to the synthesis ... Palladium-catalyzed synthesis of benzofurans via C-H activation/oxidation tandem reaction and its application to the synthesis ...
1-(Benzofuran-2-yl)-2-propylaminopentane ((-)BPAP) is a drug with an unusual effects profile. It can loosely be grouped with ... Shimazu S, Tsunekawa H, Yoneda F, Katsuki H, Akaike A, Janowsky A. Transporter Mediated Actions of R-(-)-1-(Benzofuran-2-yl)-2- ... Shimazu S, Takahata K, Katsuki H, Tsunekawa H, Tanigawa A, Yoneda F, Knoll J, Akaike A. (-)-1-(Benzofuran-2-yl)-2- ... Knoll J, Yoneda F, Knoll B, Ohde H, Miklya I. (-)-1-(Benzofuran-2-yl)-2-propylaminopentane, [(-)BPAP], a selective enhancer of ...
  • A diversity of synthetic routes can be applied to the synthesis of benzofurans. (sigmaaldrich.com)
  • Miyabe, H. Three-Component Coupling Reactions of Arynes for the Synthesis of Benzofurans and Coumarins. (mdpi.com)
  • 2014. "Three-Component Coupling Reactions of Arynes for the Synthesis of Benzofurans and Coumarins. (mdpi.com)
  • A new palladium-catalyzed method for the synthesis of benzofurans by reaction of 2-hydroxystyrenes and iodobenzenes via a C-H activation/oxidation tandem reaction has been unprecedentedly discovered. (rsc.org)
  • We report a transition metal-free synthesis of benzofurans from benzothiophenes and phenols that exploits the unique reactivity of sulfoxides. (manchester.ac.uk)
  • We have developed a one-step synthesis of benzofurans from o-iodophenol and various terminal alkynes, by using Pd catalyst supported on nano-sized carbon balls (NCB) under copper- and ligand free conditions. (koreascience.or.kr)
  • Table 3-l lists common synonyms, trade names, and other pertinent identification information for 2,3-benzofuran. (cdc.gov)
  • The benzofuran 15a could be obtained by using ethyl iodoacetate ( 14 ) as a C1-unit. (mdpi.com)
  • Pharmacological Properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: II. (aspetjournals.org)
  • ABT-239 [4-(2-{2-[(2 R )-2-methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile] exemplifies such a selective, nonimidazole H 3 R antagonist with high affinity for rat (p K i = 8.9) and human (p K i = 9.5) H 3 Rs. (aspetjournals.org)
  • One compound in particular, 4-(2-[2-(2(R)-methylpyrrolidin-1-yl)ethyl]benzofuran-5-yl)benzonitrile (ABT-239), combined potent and selective H(3) receptor antagonism and excellent pharmacokinetic and metabolic properties across species, with full efficacy in two behavioral models: a five-trial inhibitory avoidance acquisition model in rat pups at 0.1 mg/kg and a social recognition memory model in adult rats at 0.01 mg/kg. (nih.gov)
  • Natural and synthetic compounds with benzofuran derivatives have many applications as sedatives, hypotonic, agrochemicals, pharmaceuticals, and cosmetics depending on their physiological, pharmacological, and toxic properties (1-4). (thefreedictionary.com)
  • Benzofuran is the "parent" of many related compounds with more complex structures. (wikipedia.org)
  • The substituted benzofurans are a class of chemical compounds based on the heterocyclyc and polycyclic compound benzofuran. (wikipedia.org)
  • Many medicines use the benzofuran core as a scaffold, but most commonly the term is used to refer to the simpler compounds in this class which include numerous psychoactive drugs, including stimulants, psychedelics and empathogens. (wikipedia.org)
  • In general, these compounds have a benzofuran core to which a 2-aminoethyl group is attached (at any position), and combined with a range of other substituents. (wikipedia.org)
  • Palladium-catalyzed oxidative annulations between phenols and alkenylcarboxylic acids produced a library of benzofuran compounds. (diva-portal.org)
  • The dihedral angles between the mean plane of the benzofuran ring system and the pendant 4-fluorophenyl and phenyl rings are 5.93 (9) and 80.23 (5)°, respectively. (iucr.org)
  • Benzofuran fused C -2,4,6-substituted pyrimidine derivatives (4a-k) were built by cyclo condensation, Claisen-Schmidt condensation followed by cyclization via coupling of benzoyl fragments, which include benzofuran, a pyrimidine ring and C -6 substituted phenyl residue with various substituents, connected by linker-S-band. (innovareacademics.in)
  • As benzimidazole possess various types of biological activities, it has been synthesized, in the present study, a new series of (5-(3-(1 H -benzo[d]imidazol-2-yl)-4-hydroxybenzyl)benzofuran-2-yl)(phenyl)methanone analogs by using the condensation and screened for its in vitro antimicrobial activity and cytotoxicity. (biomedcentral.com)
  • The synthesized (5-(3-(1 H -benzo[d]imidazol-2-yl)-4-hydroxybenzyl) benzofuran-2-yl)(phenyl)methanone analogs were confirmed by IR, 1 H and 13 C-NMR, MS spectra and HRMS spectral data. (biomedcentral.com)
  • Animal studies have shown effects on the liver, kidneys, lungs, and stomach from exposure to high levels of 2,3-benzofuran. (cdc.gov)
  • Rats and mice that ingested high levels of 2,3-benzofuran over a short time had liver and kidney damage. (cdc.gov)
  • We do not know what the levels of 2,3-benzofuran are in soil, air, water, or food. (cdc.gov)
  • Very little is known about the possible harmful effects of 2,3-benzofuran to human health. (cdc.gov)
  • No studies have been done to test the effects of 2,3-benzofuran on the health of humans. (cdc.gov)
  • Synthesis, reactions, and application of furans and benzofurans bearing a fluorine atom and a trifluoromethyl group are reviewed. (springer.com)
  • Perkin rearrangement, where a coumarin is reacted with a hydroxide: Diels-Alder reaction of nitro vinyl furans with various dienophiles: Cycloisomerization of alkyne ortho-substituted phenols: Substituted benzofurans Furan, an analog without the fused benzene ring. (wikipedia.org)
  • Through a sequence involving an interrupted Pummerer reaction and [3,3] sigmatropic rearrangement, phenols can be combined with readily accessible yet synthetically unexplored benzothiophene S-oxides to provide C3- arylated benzofuran products. (manchester.ac.uk)
  • Substituted benzofurans were synthesized from their corresponding substituted 1-allyl-2-allyloxybenzenes using ruthenium-catalyzed C - and O -allyl isomerization followed by ring-closing metathesis. (organic-chemistry.org)
  • High selectivity was observed for C2-alkynylation of benzofurans substituted with alkyl, aryl, halogen and ether groups. (epfl.ch)
  • Copper-catalysed benzofuran synthesis: developing aryl bromide-alkenyl triflates as general heterocycle precursors. (astrazeneca.com)
  • Reactions of calcium carbide with salicylaldehyde p -tosylhydrazones or 2-hydroxyacetophenone p -tosylhydrazones provide methyl-substituted benzofuran rings in good yields in the presence of cuprous chloride as catalyst. (organic-chemistry.org)
  • In the present work, nine 1-[(2,3-dihydro-1-benzofuran-2-yl)methyl]piperazine (LINS01 series) molecules were synthesized and evaluated as H 3 R and H 4 R ligands. (frontiersin.org)
  • 1H-cyclopenta[b]benzofuran lignans from Aglaia species inhibit cell proliferation and alter cell cycle distribution in human. (nih.gov)
  • 1H cyclopenta b benzofuran lignans from Aglaia species inhibit. (nih.gov)
  • Of these, monosulfated benzofurans were the only group of molecules found to inhibit fXIa (∼100% efficacy) and led to the identification of monosulfated trimer 24 (IC50 0.82 μM) as the most potent inhibitor. (sdsc.edu)
  • Benzofuran (coumarone), a heterocyclic compound consisting of fused benzene and furan rings, has been identified as a privileged structure in medicinal chemistry. (sigmaaldrich.com)
  • For example, psoralen is a benzofuran derivative that occurs in several plants. (wikipedia.org)
  • Starting out with p-hydroxybenzaldehyde, a four step synthetic pathway led to the synthesis of a benzofuran derivative in high yield and purity using Biotage® Endeavor™ catalyst screening system. (pyrosequencing.com)
  • Benzofuran is the heterocyclic compound consisting of fused benzene and furan rings. (wikipedia.org)
  • Here we selected an unique combination of three different fused heterocyclic ring systems, where quinoline ring acts as core moiety, benzofuran nucleus substituted at second position acts as chromophore, and 3-benzoxazol-2-yl /benzothiazol-2-yl rings substituted on the fourth position of quinoline nucleus act as an electron acceptor system. (hindawi.com)
  • The photoluminescence properties of 2-(1-benzofuran-2-yl) quinoline-4-carboxylic acids (3a-b) have prompted us to replace the carboxyl group with fused heterocyclic ring system like benzoxazole 4 ( a-b ) and benzothiazole 4 ( c-d ), and to study the effect of alteration on the photoluminescence properties. (hindawi.com)
  • Benzofuran and their heterocyclic analogs represent an important class of molecules which have a wide range of pharmacological activities. (innovareacademics.in)
  • The reaction with diols delivers benzofuran derivatives via dehydrative C-H alkenylation and annulation reaction. (organic-chemistry.org)
  • Furanonaphthoquinones, atraric acid and a benzofuran from the stem barks of Newbouldia laevis. (thefreedictionary.com)
  • The direct alkynylation of benzofurans was achieved for the first time using the hypervalent iodine reagent 1-[(triisopropylsilyl)ethynyl]-1,2-benziodoxol-3(1H)-one (TIPS-EBX) based on the cooperative effect between a gold catalyst and a zinc Lewis acid. (epfl.ch)
  • A series of novel 2-(1-benzofuran-2-yl)-4-(1,3 benzoxazol-2-yl/1,3-benzothiazol-2-yl) quinoline derivatives 4(a-d) were synthesized in one step by the reaction of 2-(1-benzofuran-2-yl) quinoline-4-carboxylic acids 3(a-b) with o-aminophenol and o-amino thiophenol, respectively, using polyphosphoric acid (PPA) as a cyclizing agent. (hindawi.com)
  • Initially the two derivatives of 2-(1-benzofuran-2-yl) quinoline-4-carboxylic acid 3(a-b) were synthesized, and it was found that they emit light in the blue region of the spectrum. (hindawi.com)
  • The furoic acid route to highly functionalized benzofurans. (innovareacademics.in)
  • 1-Benzofuran-6-carboxylic acid CAS:77095-51-3 is a reagent in the development of potent LFA-1/ICAM antagonist SAR 118 CAS:1025967-78-5 as an opthalmic solution for treating dry eyes. (uchemchemicals.com)
  • 1-Benzofuran-6-carboxylic acid CAS:77095-51-3 is intermediate of Lifitegrast, which is the active ingredient in Xiidra, designed to specifically block the interaction of ICAM-1 and LFA-1, which is a key mediator of the inflammation behind Dry Eye Disease. (uchemchemicals.com)
  • 1-Benzofuran-6-carboxylic acid CAS:77095-51-3 could be supplied in different size with competitive price. (uchemchemicals.com)
  • 2,3-Dihydro-1-benzofuran-2-carboxylic acid - Not listed by ACGIH, IARC, or NTP. (molbase.com)
  • A benzofuran-containing compound, amiodarone, is one of the most therapeutically important antiarrhythmic drugs for various types of cardiac dysrhythmias [ 9 , 10 ] ( Figure 1 ). (mdpi.com)
  • Gaszner P, Miklya I. Major depression and the synthetic enhancer substances (-)-deprenyl and (-)-1-(Benzofuran-2-yl)-2-propylaminopentane. (wikidoc.org)
  • 2,3-Benzofuran is a colorless, sweet-smelling, oily liquid made by processing coal into coal oil. (cdc.gov)
  • 2,3-Benzofuran is a colorless, sweet-smelling, oily liquid which does not mix with water. (cdc.gov)
  • Our work presents the sulfated benzofuran scaffold as a promising framework to develop allosteric fXIa inhibitors that likely function through the A3 domain. (sdsc.edu)
  • 2,3-Benzofuran is not used for any commercial purposes, but the part of the coal oil that contains 2,3-benzofuran is made into a plastic called coumarone-indene resin. (cdc.gov)
  • Very little is known about the stability or breakdown of 2,3-benzofuran or of the coumarone-indene resin. (cdc.gov)
  • Workers who make coal oil or coumarone- indene resin might be exposed to 2,3-benzofuran. (cdc.gov)
  • 6-(2-aminopropyl)benzofuran (also known as 6-APB or by the brand-name Benzofury) is a popular synthetic entactogen of the phenethylamine and benzofuran chemical classes that produces a powerful, long-lived array of typical MDA-like entactogenic effects such as sedation, enhanced feelings of empathy, love, and sociability, muscle relaxation, anxiety relief and physical and cognitive euphoria when administered. (magnetresearchchemical.com)
  • Easily prepared Palladium nanoparticles catalyze a one-pot synthesis of various benzofurans via Sonogashira cross-coupling reactions under ambient conditions. (organic-chemistry.org)
  • The derivatives may be produced by substitutions at six locations of the benzofuran molecule, as well as saturation of the 2,3- double bond. (wikipedia.org)
  • In the title molecule (Fig. 1), the benzofuran unit is essentially planar, with a mean deviation of 0.007 (2) Å from the least-squares plane defined by the nine constituent atoms. (iucr.org)
  • Potential of cyclopenta[b]benzofurans from Aglaia species in cancer chemotherapy. (innovareacademics.in)
  • Lavanya A, Sribalan R, Padmini V. Synthesis and biological evaluation of new benzofuran carboxamide derivatives. (innovareacademics.in)
  • An isocyanide-mediated and Pd-catalyzed 5- exo-dig reductive cyclization of 1-(2-hydroxyphenyl)-propargyl alcohols provides 2-alkyl/benzyl benzofurans in excellent yields. (organic-chemistry.org)
  • This work suggests the potential to develop benzofuran fragments into a novel class of EcDsbA inhibitors. (edu.au)
  • Cancer of the kidneys, lungs, liver, or stomach was seen in rats and mice that ingested 2,3-benzofuran for long periods of time. (cdc.gov)
  • Some rats and mice that received 2,3-benzofuran for their whole lives developed cancer of the kidney, lung, liver, or stomach. (cdc.gov)
  • Shimazu S, Takahata K, Katsuki H, Tsunekawa H, Tanigawa A, Yoneda F, Knoll J, Akaike A. (-)-1-(Benzofuran-2-yl)-2-propylaminopentane enhances locomotor activity in rats due to its ability to induce dopamine release. (wikidoc.org)
  • Table 3-2 lists important physical and chemical properties of 2,3-benzofuran. (cdc.gov)
  • If you are exposed to a hazardous chemical such as 2,3-benzofuran, several factors will determine whether harmful health effects will occur and what the type and severity of those health effects will be. (cdc.gov)
  • (-)-1-(Benzofuran-2-yl)-2-propylaminopentane ( (-)BPAP ) is a drug with an unusual effects profile. (wikidoc.org)
  • Knoll J, Yoneda F, Knoll B, Ohde H, Miklya I. (-)-1-(Benzofuran-2-yl)-2-propylaminopentane, [(-)BPAP], a selective enhancer of the impulse propagation mediated release of catecholamines and serotonin in the brain. (wikidoc.org)
  • Oka T, Yasusa T, Ando T, Watanabe M, Yoneda F, Ishida T, Knoll J. Enantioselective Synthesis and Absolute Configuration of (-)-1-(Benzofuran-2-yl)-2-propylaminopentane ((-)BPAP), a Highly Potent and Selective Catecholaminergic Activity Enhancer. (wikidoc.org)
  • Allosteric inhibition of human factor XIa: discovery of monosulfated benzofurans as a class of promising inhibitors. (sdsc.edu)
  • Earlier, we reported on the design of sulfated benzofuran dimers (SBDs) as allosteric inhibitors of thrombin (Sidhu et al. (sdsc.edu)
  • We do not know how often the resin is used or whether any 2,3-benzofuran in the coating or packaging gets into the food. (cdc.gov)
  • A series of benzofurans (structures often targeted in diabetes and insulin control research), were synthesized to demonstrate the capabilities of Biotage® Endeavor™ for parallel hydrogenation in drug discovery. (pyrosequencing.com)
  • Results: Among the various ionic resins attempted, Amberlyst-15® in PEG-400 was the choice of selection for the synthesis of 3-benzoyl-5-hydroxy benzofuran and naphtho[1,2-b]furan derivatives at room temperature in an environmentally friendly method. (eurekaselect.com)
  • What happens to 2,3-benzofuran when it enters the environment? (cdc.gov)
  • More information on how 2,3-benzofuran enters and leaves the body is given in Chapter 2. (cdc.gov)
  • An effective, Ru-catalyzed cycloisomerization of benzannulated homo- and bis-homopropargylic alcohols affords benzofurans and isochromenes chemo- and regioselectively (5-, and 6-endo cyclizations). (organic-chemistry.org)
  • The direct synthesis of benzofuran 15b was achieved by using the active methine 18 having ketone and ester groups. (mdpi.com)
  • 2,3-Benzofuran is made by processing coal into coal oil. (cdc.gov)
  • 2,3-Benzofuran may also be formed during other uses of coal or oil. (cdc.gov)
  • download transition metal catalyzed benzofuran synthesis transition metal catalyzed heterocycle synthesis series 2017 of existing sediment, bestseller, non-Brownian exterior injustice, Centerline propagation, gland properties, facilities, limitations, related art and 2005-06-23T12:00:00Full. (adams-farm.com)
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  • The following table displays notable derivatives that have been reported: Substituted benzofurans saw widespread use as recreational drugs by being sold as research chemicals making them exempt from drug legislation. (wikipedia.org)
  • Benzofurans can be prepared by various methods in the laboratory. (wikipedia.org)