BenzocycloheptenesProtriptyline: Tricyclic antidepressant similar in action and side effects to IMIPRAMINE. It may produce excitation.Cyproheptadine: A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.Pizotyline: Serotonin antagonist used against MIGRAINE DISORDERS and vascular headaches.Nortriptyline: A metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.Loratadine: A second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (HISTAMINE H1 ANTAGONISTS) it lacks central nervous system depressing effects such as drowsiness.Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.Eryngium: A plant genus of the family APIACEAE. Members contain SAPONINS.Apiaceae: A large plant family in the order Apiales, also known as Umbelliferae. Most are aromatic herbs with alternate, feather-divided leaves that are sheathed at the base. The flowers often form a conspicuous flat-topped umbel. Each small individual flower is usually bisexual, with five sepals, five petals, and an enlarged disk at the base of the style. The fruits are ridged and are composed of two parts that split open at maturity.Myrsinaceae: A plant family of the order Primulales, subclass Dilleniidae, class Magnoliopsida.Oils, Volatile: Oils which evaporate readily. The volatile oils occur in aromatic plants, to which they give odor and other characteristics. Most volatile oils consist of a mixture of two or more TERPENES or of a mixture of an eleoptene (the more volatile constituent of a volatile oil) with a stearopten (the more solid constituent). The synonym essential oils refers to the essence of a plant, as its perfume or scent, and not to its indispensability.Tanacetum: A plant genus of the family ASTERACEAE. Some species of the CHRYSANTHEMUM and the old Pyrethrum genera have been reclassified to this genus. The common name of tansy usually refers to this but also forms part of the common name of other plants such as Tansy Ragwort (SENECIO) and Tansyaster (HAPLOPAPPUS).Mentha piperita: A plant genus of the family LAMIACEAE that is the source of peppermint oil.Plant Oils: Oils derived from plants or plant products.Cedrus: A plant genus in the family PINACEAE, order Pinales, class Pinopsida, division Coniferophyta. It is the source of cedarwood oil. Cedar ordinarily refers to this but also forms part of the name of plants in other genera.Sodium Hydroxide: A highly caustic substance that is used to neutralize acids and make sodium salts. (From Merck Index, 11th ed)Morocco: A country located in north Africa, bordering the Atlantic Ocean and the Mediterranean Sea, with a southern border with Western Sahara, eastern border with Algeria. The capital is Rabat.Botrytis: A mitosporic Leotiales fungal genus of plant pathogens. It has teleomorphs in the genus Botryotina.Antifungal Agents: Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.SesquiterpenesChloroform: A commonly used laboratory solvent. It was previously used as an anesthetic, but was banned from use in the U.S. due to its suspected carcinogenicity.Copyright: It is a form of protection provided by law. In the United States this protection is granted to authors of original works of authorship, including literary, dramatic, musical, artistic, and certain other intellectual works. This protection is available to both published and unpublished works. (from Circular of the United States Copyright Office, 6/30/2008)Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)MedlinePlus: NATIONAL LIBRARY OF MEDICINE service for health professionals and consumers. It links extensive information from the National Institutes of Health and other reviewed sources of information on specific diseases and conditions.Consumer Health Information: Information intended for potential users of medical and healthcare services. There is an emphasis on self-care and preventive approaches as well as information for community-wide dissemination and use.Social Media: Platforms that provide the ability and tools to create and publish information accessed via the INTERNET. Generally these platforms have three characteristics with content user generated, high degree of interaction between creator and viewer, and easily integrated with other sites.Dissent and Disputes: Differences of opinion or disagreements that may arise, for example, between health professionals and patients or their families, or against a political regime.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Organotin Compounds: Organic compounds which contain tin in the molecule. Used widely in industry and agriculture.CME-CarbodiimidePhenanthrenesIsocoumarins: Compounds that differ from COUMARINS in having the positions of the ring and ketone oxygens reversed so the keto oxygen is at the 1-position of the molecule.Trialkyltin Compounds: Organometallic compounds which contain tin and three alkyl groups.Pyridinium CompoundsEstersPatents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Pyrazoles: Azoles of two nitrogens at the 1,2 positions, next to each other, in contrast with IMIDAZOLES in which they are at the 1,3 positions.Receptors, sigma: A class of cell surface receptors recognized by its pharmacological profile. Sigma receptors were originally considered to be opioid receptors because they bind certain synthetic opioids. However they also interact with a variety of other psychoactive drugs, and their endogenous ligand is not known (although they can react to certain endogenous steroids). Sigma receptors are found in the immune, endocrine, and nervous systems, and in some peripheral tissues.Inventions: A novel composition, device, or process, independently conceived de novo or derived from a pre-existing model.Lomustine: An alkylating agent of value against both hematologic malignancies and solid tumors.Nitrosourea CompoundsElettaria: A plant genus of the family ZINGIBERACEAE, order Zingiberales, subclass Zingiberidae. Elettaria cardamomum (L.) Maton is the source of Cardamom used in SPICES.Amomum: A plant genus of the family ZINGIBERACEAE. Members contain aculeatin D, beta-sitosterol, and STIGMASTEROL. Some members have been reclassified to ELETTARIA and other ZINGIBERACEAE.Fumigation: The application of smoke, vapor, or gas for the purpose of disinfecting or destroying pests or microorganisms.Chlorogenic Acid: A naturally occurring phenolic acid which is a carcinogenic inhibitor. It has also been shown to prevent paraquat-induced oxidative stress in rats. (From J Chromatogr A 1996;741(2):223-31; Biosci Biotechnol Biochem 1996;60(5):765-68).Colonic Diseases: Pathological processes in the COLON region of the large intestine (INTESTINE, LARGE).Caffeic Acids: A class of phenolic acids related to chlorogenic acid, p-coumaric acid, vanillic acid, etc., which are found in plant tissues. It is involved in plant growth regulation.

gamma-Hydroxybutyrate modulates synthesis and extracellular concentration of gamma-aminobutyric acid in discrete rat brain regions in vivo. (1/37)

gamma-Hydroxybutyrate possesses most of the properties of a neurotransmitter/neuromodulator that acts via specific pathways and receptors in brain. Beside its regulatory effects on dopaminergic transmission, gamma-hydroxybutyrate was thought for many years to interfere with gamma-aminobutyric acid (GABA)ergic processes in the brain. The present study demonstrates that in the rat frontal cortex in vivo, gamma-hydroxybutyrate or its agonist NCS-356 administered systemically at a high dose (500 mg/kg) increases GABA contents in dialysates via a mechanism blocked by the peripheral administration of the gamma-hydroxybutyrate antagonist NCS-382. Under the same conditions, the extracellular concentration of this amino acid was not modified in the hippocampus. However, when administered at a low dose (250 mg/kg), gamma-hydroxybutyrate decreases GABA content of the dialysates of the frontal cortex by an NCS-382-sensitive mechanism. Spontaneous [3H]GABA release was observed in the frontal cortex of rats at 160 min after i.p. [3H]-gamma-hydroxybutyrate administration. This result indicates that gamma-hydroxybutyrate in vivo could be the precursor of an extracellular GABA pool in the frontal cortex. After i.p. [3H]-gamma-hydroxybutyrate administration in the rat, the amino acid contents of several brain regions were quantified 160 min later, and the radioactivity in each region was measured. [3H]GABA, [3H]glutamate, and [3H]glycine were detected in most, but not all, of the brain regions studied. In particular, radioactive GABA was not detected in the hippocampus. The other amino acids were not labeled. These results show that gamma-hydroxybutyrate modulates the synthesis and the extracellular concentrations of GABA in specific regions of the rat brain. Identification of these GABA pools and determination of their functional role remain to be defined.  (+info)

Binding characteristics of the gamma-hydroxybutyric acid receptor antagonist [(3)H](2E)-(5-hydroxy-5,7,8,9-tetrahydro-6H-benzo[a][7]annulen-6-ylidene) ethanoic acid in the rat brain. (2/37)

Radioligand binding studies with [(3)H](2E)-(5-hydroxy-5,7,8,9-tetrahydro-6H-benzo[a][7]annulen-6-ylidene) ethanoic acid ([(3)H]NCS-382), an antagonist of gamma-hydroxybutyric acid (GHB) receptor, revealed specific binding sites in the rat cerebral cortex and hippocampus. However, there was very little binding in the rat cerebellum, heart, kidney, liver, and lung membranes. Binding was rapid and reached equilibrium in about 5 min. Scatchard analysis of saturation isotherms revealed two different populations of binding sites in the rat cerebral cortex (K(d1), 795 nM, B(max1), 25.4 pmol/mg of protein; K(d2), 21 microM; B(max2), 178 pmol/mg of protein) as well as in the rat hippocampus (K(d1), 441 nM; B(max1), 16.2 pmol/mg of protein; K(d2), 9.8 microM; B(max2), 255 pmol/mg of protein). (+/-)Baclofen (500 microM) and gamma-aminobutyric acid (100 microM) inhibited the binding only partially, whereas (+)bicuculline, muscimol, picrotoxinin, and phaclofen did not modify the binding. Interestingly, potassium chloride (100-300 mM) inhibited [(3)H]NCS-382 binding (34-56%), and this inhibitory effect was not affected by picrotoxinin. GHB and NCS-382 completely inhibited the [(3)H]NCS-382 (16 nM) binding in the rat cerebrocortical and hippocampal membranes, and NCS-382 was found to be about 10 times more potent than GHB in this regard. A variety of ligands for other receptors did not modify the [(3)H]NCS-382 binding, thereby suggesting selectivity of this radioligand for the GHB receptor sites in the brain. Based on these observations, [(3)H]NCS-382 seems to be a better radioligand than [(3)H]GHB for investigating the role of the GHB receptors in various pharmacological actions.  (+info)

Therapeutic intervention in mice deficient for succinate semialdehyde dehydrogenase (gamma-hydroxybutyric aciduria). (3/37)

Therapeutic intervention for human succinic semialdehyde dehydrogenase (SSADH) deficiency (gamma-hydroxybutyric aciduria) has been limited to vigabatrin (VGB). Pharmacologically, VGB should be highly effective due to 4-aminobutyrate-transaminase (GABA-transaminase) inhibition, lowering succinic semialdehyde and, thereby, gamma-hydroxybutyric acid (GHB) levels. Unfortunately, clinical efficacy has been limited. Because GHB possesses a number of potential receptor interactions, we addressed the hypothesis that antagonism of these interactions in mice with SSADH deficiency could lead to the development of novel treatment strategies for human patients. SSADH-deficient mice have significantly elevated tissue GHB levels, are neurologically impaired, and die within 4 weeks postnatally. In the current report, we compared oral versus intraperitoneal administration of VGB, CGP 35348 [3-aminopropyl(diethoxymethyl)phosphinic acid, a GABA(B) receptor antagonist], and the nonprotein amino acid taurine in rescue of SSADH-deficient mice from early death. In addition, we assessed the efficacy of the specific GHB receptor antagonist NCS-382 (6,7,8,9-tetrahydro-5-[H]benzocycloheptene-5-ol-6-ylideneacetic acid) using i.p. administration. All interventions led to significant lifespan extension (22-61%), with NCS-382 being most effective (50-61% survival). To explore the limited human clinical efficacy of VGB, we measured brain GHB and gamma-aminobutyric acid (GABA) levels in SSADH-deficient mice receiving VGB. Whereas high-dose VGB led to the expected elevation of brain GABA, we found no parallel decrease in GHB levels. Our data indicate that, at a minimum, GHB and GABA(B) receptors are involved in the pathophysiology of SSADH deficiency. We conclude that taurine and NCS-382 may have therapeutic relevance in human SSADH deficiency and that the poor clinical efficacy of VGB in this disease may relate to an inability to decrease brain GHB concentrations.  (+info)

A tertiary alcohol analog of gamma-hydroxybutyric acid as a specific gamma-hydroxybutyric acid receptor ligand. (4/37)

gamma-Hydroxybutyric acid (GHB) shows great promise as a treatment for sleeping disorders but is also increasingly abused. The exact mechanism of action of GHB is yet to be delineated, but it is known to interact with specific GHB binding sites or receptors, to act as a weak agonist at GABA(B) receptors, and that GHB undergoes metabolism to GABA. In drug discrimination studies, GABA(B) agonists, and to a lesser extent GABA(A)-positive modulators, substitute for GHB. To delineate the relative contributions of each receptor system to the profile of GHB, tertiary alcohol analogs of GHB and its homolog, 5-hydroxypentanoic acid (UMB58), were prepared (UMB68 and UMB75, respectively), which cannot be metabolized to GABA-active compounds. Binding studies against [(3)H]NCS-382 [(2E)-(5-hydroxy-5,7,8,9-tetrahydro-6H-benzo[a][7]annulen-6-ylidene) ethanoic acid] showed that the tertiary alcohol analog of GHB (UMB68) has similar affinity to GHB, with the longer chain analogs possessing lower affinity. Against [(3)H]GABA, UMB68 showed no affinity (IC(50) >100 microM) at GABA(A) or GABA(B) receptors. In vivo studies showed that, at behaviorally active doses, rats trained to discriminate GHB did not recognize the novel ligands as GHB. Thus, UMB68 is a selective GHB receptor ligand in binding assays, will not undergo metabolism to GABA-active compounds, and does not show the same effects as GHB in vivo. These data suggest that, although UMB68 binds to the GHB receptor, it does not have the observed GABA receptor-mediated effects of GHB in vivo and could provide a novel tool for studying the pharmacology of the GHB receptor in the absence of complicating GABAergic effects.  (+info)

Effects of gamma-hydroxybutyrate (GHB) on schedule-controlled responding in rats: role of GHB and GABAB receptors. (5/37)

Gamma-hydroxybutyrate (GHB), a metabolite of gamma-aminobutyric acid (GABA), is an increasingly popular drug of abuse and was recently approved for the treatment of narcolepsy (Xyrem). GHB and GABA receptors have been implicated in mediating effects of GHB; however, the relative importance of each of these receptors is unclear. This study evaluated the effects of selective antagonists in combination with GHB and related compounds on schedule-controlled responding. Eight male Sprague-Dawley rats responded under a fixed-ratio schedule of food presentation. Cumulative dose-effect curves were generated and ED50 values calculated to evaluate the relative potency at decreasing responding. The rank-order potency was as follows: diazepam = baclofen > gamma-butyrolactone (GBL) > 1,4-butanediol (1,4-BDL) = GHB. All compounds decreased responding 20 min after administration. The duration of action of diazepam, GHB, and GBL was shorter than that of 1,4-BDL and baclofen. p-3-Aminopropyl-p-diethoxymethyl phosphinic acid (CGP 35348) antagonized the rate-decreasing effects of baclofen and not GHB; flumazenil antagonized the effects of diazepam and not GHB. The GHB receptor antagonist (2E)-(5-hydroxy-5,7,8,9-tetrahydro-6H-benzo[a][7]annulen-6-ylidene ethanoic acid (NCS-382) did not attenuate the rate-decreasing effects of GHB, baclofen, or diazepam; larger doses of NCS-382 further decreased rate of responding when given in combination with each of these compounds. These studies show that GBL, 1,4-BDL, and GHB differ significantly in potency and duration of action. The ability of CGP 35348 to antagonize the rate-decreasing effects of baclofen may be limited by the involvement of multiple GABAB receptor subtypes and the lack of antagonism of GHB by NCS-382 may be due to its own GHB-like effects.  (+info)

Pathway-specific action of gamma-hydroxybutyric acid in sensory thalamus and its relevance to absence seizures. (6/37)

The systemic injection of gamma-hydroxybutyric acid (GHB) elicits spike and wave discharges (SWDs), the EEG hallmark of absence seizures, and represents a well established, widely used pharmacological model of this nonconvulsive epilepsy. Despite this experimental use of GHB, as well as its therapeutic use in narcolepsy and its increasing abuse, however, the precise cellular mechanisms underlying the different pharmacological actions of this drug are still unclear. Because sensory thalamic nuclei play a key role in the generation of SWDs and sleep rhythms, and because direct injection of GHB in the ventrobasal (VB) thalamus elicits SWDs, we investigated GHB effects on corticothalamic EPSCs and GABAergic IPSCs in VB thalamocortical (TC) neurons. GHB (250 microm-10 mm) reversibly decreased the amplitude of electrically evoked EPSCs and GABAA IPSCs via activation of GABAB receptors; however, approximately 60% of the IPSCs were insensitive to low (250 microm-1.0 mm) GHB concentrations. The putative GHB receptor antagonist NSC 382 applied alone had a number of unspecific effects, whereas it either had no action on, or further increased, the GHB-elicited effects on synaptic currents. Low GHB concentrations (250 microm) were also effective in increasing absence-like intrathalamic oscillations evoked by cortical afferent stimulation. These results indicate that low concentrations of GHB, similar to the brain concentrations that evoke SWDs in vivo, differentially affect excitatory and inhibitory synaptic currents in TC neurons and promote absence-like intrathalamic oscillations. Furthermore, the present data strengthen previous suggestions on the GHB mechanism of sleep promotion and will help focus future studies on the cellular mechanisms underlying its abuse.  (+info)

Synthesis of 1-benzothiepine and 1-benzazepine derivatives as orally active CCR5 antagonists. (7/37)

Quaternary ammonium benzocycloheptene compound 1 has previously been reported as a clinical candidate for an injectable CCR5 antagonist. In order to develop an orally active CCR5 antagonist, derivatives of tertiary amine benzocycloheptene 2, the chemical precursor to 1, were investigated. The benzocycloheptene ring was converted to benzothiepine and benzazepine rings and it was found that these changes could enhance the potency of tertiary amine derivatives. In particular, the 1-benzothiepine-1,1-dioxide 11b and the N-methyl-1-benzazepine 18 showed increased activity and good preliminary pharmacokinetic properties. The synthesis of 1-benzothiepine and 1-benzazepine derivatives and their activity are described.  (+info)

Metabolism of pyrogallol to purpurogallin by human erythrocytic hemoglobin. (8/37)

The aim of this study was to investigate the oxido-reductive reactions of human hemoglobin with pyrogallol and the metabolism of pyrogallol by the protein, which contains a protoporphyrin IX like cytochrome P-450. Pyrogallol, having three hydroxy groups at the adjacent positions in the benzene ring, oxidized human oxyhemoglobin to methemoglobin and reduced human methemoglobin to oxyhemoglobin. Since superoxide dismutase and catalase inhibited these reactions extensively, active oxygens such as superoxide and hydrogen peroxide were considered to be involved in the oxido-reductive reaction of human hemoglobin by pyrogallol. It was also found that the metabolism of pyrogallol to purpurogallin occurred quickly in human erythrocytes, i.e., when pyrogallol was added to human erythrocyte suspension, it oxidized intracellular hemoglobin and produced purpurogallin. The metabolism of pyrogallol to purpurogallin was explained by the pyrogallol oxidation with superoxide and hydrogen peroxide produced during the oxido-reductive reactions of human hemoglobin with pyrogallol. The present results show that human erythrocytes can metabolize pyrogallol, suggesting that the cells may be involved in the metabolism of some drugs in the human body.  (+info)

Introduction. PREPARATION OF ETHANOL AND ETHANOIC ACID AIM: To obtain pure samples of Ethanol (CH3CH2OH) and Ethanoic Acid (CH3COOH) from fermented Yeast (Saccharomyces Cerevisiae). BACKGROUND INFORMATION: The use of yeast in food production is the oldest and most extensive contribution made by any group of microorganisms. A most common substrate that yeast can work with is GLUCOSE. Glucose is a monosaccharide, which are sweet crystalline sugars that dissolve easily in water to form sweet solutions. Monosaccharides have the general formula (CH2O)n and consist of a single sugar molecule. Glucose is the simplest and most common monosaccharide. It is a Hexose sugar and therefore has the formula C6H12O6. Glucose can exist in two possible ring forms, known as the alpha (?) and beta (?) forms: The hydroxyl group on Carbon atom 1 can project below the ring (? glucose) or above the ring (? glucose). Molecules like this, which have the same molecular formula but a different structural formula, are said ...
Acetic acid (ethanoic acid) and hydrochloric acid react with KOH solution. The enthalpy of neutralisation of ethanoic acid is - 55.8 kj /mol while that of hydrochloric acid is - 57.3 kJ /mol. Can you think of why are the…
20% ACETIC ACID CH3COOH, Ethanoic acid. Lab Reagent. Descaler to remove limescale. Natural, eco friendly weed killer. Rust remover. Stop bath photography.
Find right answers right now! Chemical equation for the reaction of ethanoic acid with potassium? More questions about Science & Mathematics
Solution for question: How Will You Convert Methanol to Ethanoic Acid concept: Amines - Nomenclature. For the courses CBSE (Arts), CBSE (Commerce), CBSE (Science), PUC Karnataka Science
The production of colours by the action of the enzyme peroxidase on various amino and phenolic compounds has been recorded from time to time, but such reactions have, in general, been regarded merely as tests for the presence of peroxidase, and the nature of the coloured products has been determined only in a few instances. The fairly wide distribution of the enzyme, more particularly in plants, suggests that it has considerable biological importance, but the role that it plays in metabolic processes has not yet been elucidated. From the work of Elliott (1932, a, b), it would appear that the enzyme is not concerned with general oxidative katabolism since it does not attack the majority of amino-acids, fatty acids, and carbohydrates. On the other hand, where the products of oxidation have been investigated, they have proved to be, in general, of higher molecular weight than the substrate. Thus, for example, guaiacol is oxidized to tetraguaiacol (Bertrand, 1903), pyrogallol to purpurogallin ...
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Benzocycloheptenes and heterocyclic analogues as potential drugs. I. N-Substituted derivatives of 5-amino-6,7,8,9-tetrahydro-5H-benzocycloheptene and some other compounds ...
To evaluate the effects of C-ring substituents on the absorption maxima, each compound was compared to the parent (2a) bearing only the methoxy substituent on the B-ring. F-BODIPY 2a itself has a maximum absorbance wavelength of 530 nm, which is hypsochromically shifted by 44 nm from the unsubstituted pyrrolyldipyrrin F-BODIPY.16 This indicates that the electron-donating methoxy group causes a blue-shift in absorption. All modifications to the C-ring (2b-2l) bathochromically shifted the absorbance wavelength (9-35 nm) compared to the unsubstituted, methoxy bearing F-BODIPY 2a (see ESI, Fig. S3 and S4†). The greatest shift in absorption wavelength maxima of the C-ring modified pyrrolyldipyrrin F-BODIPYs occurred with the alkyl and ethanoic acid derivative substituents: 2b, 2j and 2k bearing a -CH2CH3, -CH2C(O)NEt2 and -CH2CO2Bn group, respectively. This trend is in agreement with that observed for F-BODIPYs whereby as the core becomes more alkyl substituted, the fluorophore absorbs at a higher ...
A colourless liquid acyl chloride (see acyl halides), CH3COCl, with a pungent smell; r.d. 1.105; m.p. -112.15°C; b.p. 50.9°C. It is made by reacting ethanoic acid with a halogenating agent such as phosphorus(III) chloride, phosphorus(V) chloride, or sulphur dichloride oxide and is used to introduce ethanoyl groups into organic compounds containing -OH, -NH2, and -SH groups. See acylation. ...
Thanks to the big screen, many of us think of acids as dangerous, burn-through-anything substances. Think of those scenes in the Alien movies, where the aliens blood drips through solid metal, destroying everything in its path. Of course the vast majority of acids are much more boring. Vinegar (which contains ethanoic acid) and citric acid (found in, guess what, citrus fruits)…
Thanks to the big screen, many of us think of acids as dangerous, burn-through-anything substances. Think of those scenes in the Alien movies, where the aliens blood drips through solid metal, destroying everything in its path. Of course the vast majority of acids are much more boring. Vinegar (which contains ethanoic acid) and citric acid (found in, guess what, citrus fruits)…
... (also called ethanoic acid) is a weak organic acid. Unlike a lot of other food additives, acetic acid is commonly used in home cooking.
Acids are an important group of chemicals. Organic acids are characterised by the presence of a -COOH group attached to a carbon atom. In this experiment, some typical properties of a weak organic acid are observed.
You are viewing an interactive 3D depiction of the molecule (2E)-2-[(Z)-[3-hydroxy-2-methyl-5-(phosphonooxymethyl)pyridin-1-ium-5-id-4-ylidene]methyl]iminopropanoic acid (C11H20N2O7P+) from the PQR.
Benzocycloheptenes are cycloheptenes with additional benzene rings attached. Most have two benzene rings, and are called "dibenzocycloheptenes". Some benzocycloheptenes and substituted benzocycloheptenes have medical uses as antihistamines, anticholinergics, antidepressants, antiserotonergics. Examples include: Antihistamines and Antiserotonergics Azatadine Desloratadine Loratadine Rupatadine Cyproheptadine Ketotifen Pizotifen Anticholinergics Deptropine Anticonvulsants Oxitriptyline Antidepressants and Anticholinergics Amineptine Amitriptyline Nortriptyline Noxiptyline Octriptyline Protriptyline Various Cyclobenzaprine Intriptyline Toll-like receptor 4 investigating probable antagonistic (antiinflammatory) property of several TCA based molecules Benzocycloheptenes at the US National Library of Medicine Medical Subject Headings (MeSH ...
Introduction. I.B. CHEMISTRY: PRACTICAL 08-12-12. P2,P3,& P4-STOICHIOMETRY SULAIMAN JALLOH AIM: 1) To prepare a standard solution of potassium hydrogen phthalate by weighing and dissolving it water of correct volume. 2)To use the standard solution of 1) to standardize(find the concentration of) sodium hydroxide solution. 3)To determine the percentage of ethanoic acid,by volume,in vinegar,by titrating with standardized sodium hydroxide in 2) 1) MAKING A STANDARD SOLUTION OF POTASSIUM HYDROGEN PHTHALATE RAW DATA TABLE mass of weighing bottle,m+/-0.01g Volume of solution titrated,v+/-0.15 Concentration of sodium hydroxide given ,Cb/mol/ 33.88 250.00 0.1 The purity of the acid is given as 99.5+/-0.5% Calculations for the mass of the acid needed to make 250 of solution of the acid. Equation for the reaction: C6H5COOKCOOH+NaOH C6H5COOKCOONa+H2O so,the mole ratio of the acid to base is 1:1 This means 1 mole of acid gives 1 mole of the base. number of moles of sodium hydroxide,Nb=c v where ...
Ethanal. Computer illustration of a molecule of ethanal, or acetaldehyde (formula CH3CHO). Atoms are depicted as cylinders and are colour-coded: carbon (yellow), hydrogen (white) and oxygen (red). Ethanal is a colourless liquid with a pungent odour. It is mainly used in the chemical industry, in the preparation of ethanoic acid, ethanoic anhydride and n-butanol. - Stock Image A700/0144
179 matching references were found. Chao J., Ideal gas thermodynamic properties of ethane and propane, J. Phys. Chem. Ref. Data, 1973, 2, 427-438. [all data] Chao J., Ideal gas thermodynamic properties of ethylene and propylene, J. Phys. Chem. Ref. Data, 1975, 4, 251-261. [all data] Chao J., Ideal gas thermodynamic properties of propanone and 2-butanone, J. Phys. Chem. Ref. Data, 1976, 5, 319-328. [all data] Chao J., Ideal gas thermodynamic properties of methanoic and ethanoic acids, J. Phys. Chem. Ref. Data, 1978, 7, 363-377. [all data] Chao J., Perfect gas thermodynamic properties of methanal, ethanal and their deuterated species, Thermochim. Acta, 1980, 41, 41-54. [all data] Chao J., Chemical thermodynamic properties of toluene, o-, m- and p-xylenes, Thermochim. Acta, 1984, 72, 323-334. [all data] Chao J., Thermodynamic properties of key organic oxygen compounds in the carbon range C1 to C4. Part 2. Ideal gas properties, J. Phys. Chem. Ref. Data, 1986, 15, 1369-1436. [all data] Chao J., Ideal ...
Can anyone on here help with this please?. It is well known that acetobacter will cause dilute solutions of ethanol to be oxidised to ethanoic acid when left standing exposed to air; this being the reason that wine left standing in air will spoil and taste vinegary.. It is also reported that different strains of the bacteria can produce other compounds such as dihydroxyacetone and gluconic acid from other starting materials. The bacteria are therefore clearly versatile.. This suggests that in addition to ethanol a wide variety of alcohols in dilute aqueous solution may be oxidised to carboxylic acids when exposed to the atmosphere which will normally contain these bacteria.. However I cannot find any specific references to support this broader suggestion, neither in my textbook collection, which is substantial, nor on the internet. There are articles and statements which come close but I cant find an authoritative source (except one which I am doubtful about) which states categorically that all ...
Synonyms: Acetic acid; Acetic acid glacial; Ethanoic acid; Ethylic acid; glacial acetic acid; Methanecarboxylic acid; Shotgun; TCLP extraction fluid 2; vinegar; Vinegar acid. ...
Synonyms for acetic acid in Free Thesaurus. Antonyms for acetic acid. 1 synonym for acetic acid: ethanoic acid. What are synonyms for acetic acid?
Acetic acid is a chemical reagent which has a number of applications in the various sectors, for instance, the industrial sector. The acetic acid is a methane carboxylic or ethanoic acid which has a strong pungent smell and a very distinct sour taste. It is produced synthetically as well as by bacterial fermentation method. Acetic…
MODEL RELEASED. Using a pH meter. Schoolgirl using a pH meter on a solution of dilute ethanoic acid (CH3.COOH). The display shows an acidic pH of 4.90. A pH reading measures the concentration of free hydrogen ions. A pH below 7 (acidic) is a higher concentration of hydrogen ions than found in water (pH 7, neutral). A pH above 7 (alkaline) is a lower concentration than found in water. - Stock Image H460/0239
Gamma-Hydroxybutyrate (Ghb) information based on scientific evidence includes description, drug interactions, safety concerns, and effectiveness.
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Ketotifen Fumarate Synonyms:10h-Benzo(4,5)Cyclohepta(1,2-b)Thiophen-10-One,4,9-Dihydro-4-(1-Methyl-4-Pipe;Hc20-511fumarate;Zaditen;4-(1-Methyl-4-Piperidylidene)-4h-Benzo[4,5]Cyclohepta[1,2-b]Thiophen-10(9h)-One Hydrogen...
Five days of gamma-hydroxybutyrate (GHB) administration (3 x 500 mg kg(-1) day(-1) i.p.) to rats resulted in a significant decrease in the density of GHB receptors measured in the whole rat brain without modification of their corresponding affinity. Similar administration of (-)-sulpiride (2 X 100 m …
They are named using the alkane, followed by "-oic acid", for example; CH3CH2COOH is ethanoic acid, as it has two carbons attached to the carboxyl group. For acids with two carboxyl groups, the suffix "-dioic acid" is added instead ...
The global demand of Acetic Acid is around 6.5 million tonnes per year. The name is derived from acetum, the Latin name for Vinegar. Acetic acid, also known as ethanoic acid, is an organic acid that gives vinegar its sour taste and pungent smell.
546-89-4 Lithium acetate testing. Laboratory testing for CAS number 546-89-4. acetic acid lithium salt, ethanoic acid lithium salt,. This chemical is solid
3-Ethyl-2-[[3-[3-[3-[(3-ethyl-1,3-benzothiazol-2-ylidene)methyl]-5,5-dimethylcyclohex-2-en-1-ylidene]prop-1-enyl]-5,5-dimethylcyclohex-2-en-1-ylidene]methyl]-1,3-benzothiazol-3-ium iodide/ACM15979198 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
2 per cent); в unspecifiedimpuritiesforeachimpurity,notmorethan 0. Relative retention with reference to cisplatin (retention time about 3. Her visual acuity Buy Kamagra ups correctable to 2020 bilaterally. 3-(5H-dibenzoa,d7annulen-5-ylidene)-N,N-dimethylpropan- 1-amine (cyclobenzaprine), C.
The CDMA Development Group (CDG) and the Third Generation Partnership Project 2 (3GPP2) welcomed the latest member of the CDMA2000 family on Monday, with the publication of the Ultra Mobile Broadband (UMB) air interface specification.
You are viewing an interactive 3D depiction of the molecule 3-[5-[(e)-[(5e)-5-[[5-[(e)-[4-(2-carboxyethyl)-3-methyl-5-oxo-pyrrol-2-ylidene]methyl]-3-methyl-4-vinyl-1h-pyrrol-2-yl]methylene]-4-methyl-3-vinyl-pyrrol-2-ylidene]methyl]-4-methyl-2-oxo-pyrrol-3-yl]propanoic acid (C33H26N4O6) from the PQR.
The chemical name for HC2H3O2 is acetic acid. Most people recognize acetic acid, when it is diluted with water, as vinegar. Acetic acid is also known as ethanoic...
Structure, properties, spectra, suppliers and links for: Isopropyl [(2-hexyl-6-oxo-7,8,9,10-tetrahydro-6H-benzo[c]chromen-3-yl)oxy]acetate.
Z)-2-hydroxy-2-((8S,9S,10R,11S,13S,14S)-11-hydroxy-10,13-dimethyl-3-oxo-1,2,3,6,7,8,9,10,11,12,13,14,15,16-tetradecahydro-17H-cyclopenta[a]phenanthren-17-ylidene)acetaldehyde ...
8-methoxy-2,3,4,9-tetrahydro-1H-beta-carbolin-1-one - chemical structural formula, chemical names, chemical properties, synthesis references
2-[(8Z,10Z)-8,10-dodecadienyloxy]tetrahydro-2H-pyran - chemical structural formula, chemical names, chemical properties, synthesis references
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Read about Gamma-hydroxybutyrate and Gamma-butyrolactone Abuse, and learn m ore about GBL & GHB abuse on Gamma-hydroxybutyrate and Gamma-butyrolactone Abuse page
Global Acetic Acid Market: Overview. The demand within the global acetic acid market acid has been rising on account of advancements in the chemical industry. Acetic acid is a pungent-smelling, colourless liquid that has commendable applications across a wide array of industries. The chemical formula of acetic acid is CH3COOH, and is commonly known as ethanoic acid. Acetic acid, in its undiluted form, is known as glacial acetic acid, and it has a sour taste. Acetic acid is the key component in vinegar, and this factor has also led to the popularity of the global acetic acid market.. Several new applications of acetic acid have been discovered over the past decade. This factor has played an integral role in enhancing the growth prospects of the global acetic acid market in recent times. Cellulose acetate and polyvinyl acetate are amongst other key categories of compounds that are processed with the help of acetic acid. Owing to the aforementioned dynamics, the global market for acetic acid is ...
Gamma-hydroxybutyrate or GHB (also known as liquid X or g-juice) is an illegal drug that is frequently used to incapacitate victims in order to sexually abuse them. A central nervous system depressant, GHB was once sold in health food stores to bodybuilders because it was believed to help stimulate muscle growth. It was pulled off the market in 1990 because of its bad side effects.
Issue in Honor of Prof. J. Elguero and P. Molina ARKIVOC 2005 (ix) 200-206 Synthesis of 2- and 4-hydroxymethyl Loratadine, usual impurities in Loratadine syrup formulations Verónica Cerrada, M. Paz Matía-Martín, J. Luis Novella, and Julio Alvarez-Builla* Planta Piloto de Química Fina, Universidad de Alcalá. 28871 Alcalá de Henares, Madrid, Spain E-mail: [email protected] Dedicated to Prof. José Elguero (received 31 Dec 04; accepted 21 Mar 05; published on the web 25 Mar 05) Abstract The synthesis of two contaminants of Loratadine, generated when the product is formulated as a syrup, is described. The products, identified as 2- and 4-hydroxymethyl derivatives of the starting compounds, are obtained by the corresponding substitution of the pyridine moiety of Loratadine. Keywords: Fused pyridines, pharmaceuticals, Loratadine, synthesis, contaminants Introduction Loratadine, 1, is [4-(8-chloro-5,6-dihydrobenzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine -1-carboxylic acid ethyl ...
Mice lacking the Axl receptor tyrosine kinase (RTK) and its family members exhibit detrimental effects on their reproductive ability. AXL is localized to Sertoli cells, which are the major nurturing cells in the seminiferous ...
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Rabbit recombinant monoclonal CXCR4 antibody [UMB2] - BSA and Azide free. Validated in WB, IHC, Flow Cyt, ICC/IF and tested in Human. Cited in 15 publication(s).
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After a video surfaced of actress Mischa Barton behaving strangely, she released a statement explaining shed been given the date rape drug GHB.
Looking for online definition of AXL receptor tyrosine kinase in the Medical Dictionary? AXL receptor tyrosine kinase explanation free. What is AXL receptor tyrosine kinase? Meaning of AXL receptor tyrosine kinase medical term. What does AXL receptor tyrosine kinase mean?
German chemist, generally regarded as the founder of modern organic chemistry with his synthesis of acetic acid (ethanoic acid) - an organic compound - from inorganic starting materials. He was first to applyelectrolysis to organic synthesis. Kolbe electrolysis of fatty (alkanoic) acids was the first known electrochemical synthesis. Kolbe was a German chemist. He was born near Gottingen and educated there.…
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Chemical Equation Presented) Cyclization reactions involving cyanoacetylated bisindoles have been studied, providing access to various novel cyclohepta[2,1-b:3,4-b′]diindole derivatives as well as some related fused pentacyclic systems. Treatment of 3-cyanoacetyl-2,3′-diindolylmethane with methanesulfonic acid gave 6-(cyanomethyl)indolo[3,2-b]carbazole in a good yield.. ...
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Page contains details about 1-propyl-2-[2-(3,3-trimethyl-1,3-dihydro-indol-1-ylidene)-ethylidene]-3-dicyanovinyl-indan-1-one film on ITO substrate . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
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GHB (gamma-hydroxybutyric-acid) is a drug that was initially synthesized in 1874 by Alexander Zaytsev, but its effects werent researched in humans until
Acetic acid, also known as acetyl hydroxide, glacial acetic acid and ethanoic acid, is a free-flowing liquid with a pungent, vinegar like odour. It is an important chemical reagent and an industrial chemical with its global demand growing at around 3-4% annually. Developed by BASF and improved by Monsanto in the 1960s, carbonylation of methanol catalyzed by rhodium currently represents the most popular technology for its industrial production.. Acetic acid finds applications in the manufacturing of a number of chemical compounds, insecticides, cosmetics, dyes, plastics, pharmaceuticals, antibiotics, etc. Acetic acid also provides the necessary acidity in the number of processes carried out in an aqueous media. Dilute acetic acid is used either or both as a preservative and flavoring agent in food stuffs such as condiments, jellies, confectionery and pickled vegetables. It is also used as a coagulant for rubber latex in the manufacturing of elastic threads, as a solvent for gums, resins and ...
Podofilox, also called podophyllotoxin, is a purer and more stable form of podophyllin in which only the biologically active portion of the compound is present. Podofilox is used to remove certain types of warts on the outside skin of the genital areas ...
In our last episode of the season, we look at 5 recent publications in the field of toxicology. Steuer, A. et al. Identification of new urinary gamma-hydroxybutyric acid markers applying untargeted metabolomics analysis following placebo-controlled administration to humans. (2019) Drug Testing an...
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GHB, a naturally occurring metabolite of gamma-aminobutyric acid (GABA), is an inhibitory neurotransmitter that mediates sleep cycles, cerebral metabolism, memory and emotional control. Synthetic GHB, originally used by body builders for its putative anabolic effects, has more recently been abused for its sedative, euphoriant and aphrodisiac effects and as a
GHB, a naturally occurring metabolite of gamma-aminobutyric acid (GABA), is an inhibitory neurotransmitter that mediates sleep cycles, cerebral metabolism, memory and emotional control. Synthetic GHB, originally used by body builders for its putative anabolic effects, has more recently been abused for its sedative, euphoriant and aphrodisiac effects and as a
The thermolysis of several N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)pyridin-n-amines (where n = 2, 3 and 4) gives a mixture of thiazolopyridine-2-carbonitriles in low to moderate yields. Introduction, by design, of a chlorine substituent at the C2 or C4 position of N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)py
System contamination is a significant issue for labs analyzing gamma-hydroxybutyrate (GHB) as typical methods include derivatization and liquid injection. Here, an acid conversion solvent extraction method is evaluated for compatibility with both headspace and liquid injection techniques. This extraction method can improve lab efficiency and reduce contamination by eliminating the use of derivatization reagents.
Benzene, 1,1-(3-cyclohexen-1-ylidene)bis- | C18H18 | CID 602040 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Abstract: The structures of the novel triazolobenzothia-zines 2,4-di-hydro-1H-benzo[b][1,2,4]triazolo[4,3-d][1,4]thia-zin-1-one (IDPH-791), C9H7N3OS, (I), a potential muscle relaxant, its benzoyl derivative, 2-(2-oxo-2-phenyl-ethyl)-2,4-dihydro-1H-benzo[b][1,2,4]triazolo[4,3-d][1,4]thia-zin-1-one, C20H17N3O4S, (II), and the ...
Glufosinate-ammonium is a non-selective herbicide and is synthetically produced compound from the chemical phosphinic acid. Glufosinate-ammonium was originally isolated from ...
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Finden Sie alle Bücher von Herausgeber: Source: Wikipedia - Psychoactive Drugs: Psychopharmacology, Mood Stabilizer, Cannabis, Stimulant, Coleus, Inhalant, Valerian, Gamma-Hydroxybutyric Acid. Bei der Büchersuchmaschine eurobuch.com können Sie antiquarische und Neubücher VERGLEICHEN UND SOFORT zum Bestpreis bestellen. 1156819652
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Nonyx Nail Clarifying Basecoat clears your toenails and fingernails of unsightly yellow keratin debris buildup while still allowing you to wear your favorite nail polish! Stop hiding your toes this summer and have clear, healthy looking nails in just 3 to 9 months. Simply apply the nail clarifying basecoat directly to the nail prior to polishing.. Suggest Use: Apply to clean, bare nails and let dry, may be used under nail polish. Remove polish and basecoat, wash nails and reapply twice a month. After 3-6 weeks begin scraping out any softened keratin debris. Continue for 3-9 months or until nails are clear. Approx. 6 month supply.. Ingredients: Deionized water, ethanoic acid, fragrance, xanthan gum.. Paraben and preservative free.. FAQs. What is keratin debris?. Keratin debris is the white, yellow or brown discoloration or granular build-up that you see on or under your toenail or fingernail. If thick, keratin debris build-up can cause your nail to separate from the nail bed.. How long will it ...
63886-53-3 - XRESZUDRGQQLFF-UHFFFAOYSA-N - Phosphinic acid, diethyl-, anhydride with diethyl phosphate - Similar structures search, synonyms, formulas, resource links, and other chemical information.
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In ,35d2e272.257297 at news.twics.com, patanie at pasdepub.com writes: , ,Neurosci Lett 1997 Mar 7;224(1):71-74 , ,Naloxone reverses the inhibitory effect of ,gamma-hydroxybutyrate on central DA release in vivo in ,awake animals: a microdialysis study. , ,Feigenbaum JJ, Howard SG , ,Department of Research and Development, American Institute of ,Biotechnology, Elk Grove Village, ,IL 60007-1462, USA. , ,gamma-Hydroxybutyrate (GHB) is a 4-carbon anesthetic that acts ,primarily by inhibiting presynaptic ,dopamine (DA) release in vivo. Nonsense. GHB causes none of the expect effects of a an antidopaminergic. No stiffness, no Parkinsonian symptoms, no flattening of affect, no blunting of emotions. Its not a THING like any neuroleptic. If anything, its effects in vivo somewhat resemble gabanergics, such as gabapentin. But since GHB is a bonafide neurotransmitter, I imagine that most of its effect is via acting on receptors made just for it. In short, its a brand new class of drug (in the US, at ...
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
When a date rape drug begins to cause symptoms and how long symptoms last depends on how much you are given and whether is mixed with alcohol or other drugs.
5,12-Naphthacenedione,8-ethyl-7,8,9,10-tetrahydro-1,4,6,8,11-pentahydroxy-7-[[2,3,6-trideoxy-3-(dimethylamino)-4-O-[(2S,5S,6S)-tetrahydro-6-methyl-5-[[(2S,5S,6S)-tetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl]oxy]-2H-pyran-2-yl]-a-L-lyxo-hexopyranosyl]oxy]- (9CI ...
chemBlink provides information about CAS # 13525-99-0, Bis(2-ethylhexyl)phosphinic acid, Di(2-ethylhexyl)phosphinic acid, P 229, P 229 (phosphorus compound), PIA 8, molecular formula: C16H35O2P.
TY - JOUR. T1 - Stereocontrolled synthesis of oxygen-bridged polycycles via intermolecular [3+2] cyclization of platinum-bound pyrylium with alkenes. AU - Oh, Chang Ho. AU - Yi, Hyun Jik. AU - Lee, Ji Ho. AU - Lim, Dong Hee. PY - 2010/4/21. Y1 - 2010/4/21. N2 - 2-(3-Benzyloxy)prop-1-ynyl)benzaldehyde with PtCl2 in toluene would form Pt-pyryliums that underwent [3+2] cycloaddition with alkenes to the oxygen-bridged (5H-benzo[7]annulen-5-ylidene)platinum(ii) intermediates with good stereoselectivities. Their tandem rearrangement afforded diverse types of polycycles depending on the electronic nature of the alkenes.. AB - 2-(3-Benzyloxy)prop-1-ynyl)benzaldehyde with PtCl2 in toluene would form Pt-pyryliums that underwent [3+2] cycloaddition with alkenes to the oxygen-bridged (5H-benzo[7]annulen-5-ylidene)platinum(ii) intermediates with good stereoselectivities. Their tandem rearrangement afforded diverse types of polycycles depending on the electronic nature of the alkenes.. UR - ...
4-Hydroxybutyric acid (GHB) is a precursor and a metabolite of gamma-aminobutyric acid (GABA), it is anticipated that GHB acts as a central nervous. system (CNS)neuromodulator, mediating its effects through GABA and GHB-specific receptors, or by affecting dopamine transmission.(PMID: 16620539 ). Gamma-hydroxybutyric acid (GHB) occurs naturally in all. mammals, but its function remains unknown. GHB is labeled as an illegal drug in most countries,but also used as a legal drug (Xyrem) in patients with narcolepsy. In high doses, GHB inhibits the CNS, inducing sleep and inhibiting the respiratory drive. In lower doses, its euphoriant effect predominates (PMID: 17658710 ...
0046] The XRPD pattern for another polymorph of (S)-3-aminomethyl-7-(3-hydroxy-propoxy)-3H-benzo[c][1,2]oxaborol-1-ol.HCl- , referred to as polymorph form HCl4, and its 2-theta (20) values are shown in FIGS. 4A and 4B. Additional studies, including a single crystal form screen, verify that HCl4 is the most stable polymorph of (S)-3-aminomethyl-7-(3-hydroxy-propoxy)-3H-benzo[c][1,2]oxaborol-1-ol.HCl- . In an exemplary embodiment, the invention provides polymorph form HCl4 having, upon XRPD analysis, any 10, any 9, any 8, any 7, any 6, any 5, any 4, any 3, any 2 or any 1 of the peaks shown in FIGS. 1A and 1B, ±2°2θ, ±1.7°2θ, ±1.5°2θ, ±1.2°2θ, ±1.0°2θ, ±0.9°2θ, ±0.8°2θ, ±0.7°2θ, ±0.6°2θ, ±0.5°2θ, ±0.4°2θ, ±0.3°2θ, ±0.2°2θ, or ±0.1°2θ. In an exemplary embodiment, the invention provides polymorph form HCl4 having, upon XRPD analysis, any 10 of the peaks shown in FIGS. 4A and 4B, ±2°2θ, ±1.7°2θ, ±1.5°2θ, ±1.2°2θ, ±1.0°2θ, ±0.9°2θ, ±0.8°2θ, ...
chemBlink provides information about CAS # 581092-53-7, Optical Dye DCY02, 2-[3-[1,3-Dihydro-1,3-dimethyl-1-(phenylmethyl)-2H-benz[e]indol-2-ylidene]-1-propenyl]-1,3-dimethyl-1-(phenylmethyl)-1H-benz[e]indolium hexafluorophosphate(1-), molecular formula: C45H41N2.F6P.
Drug Classification: Depressant Drug Schedule: I. Addiction Potential: HIGH. Modes of Administration: Oral (powder, pill, liquid). Onset of Drug Effect(s): Initial effects occur in 10 to 20 minutes, depending on when and how much someone has consumed. Acute effects last 1-½ hours with lesser effects for another four hours. GHB is out of the body within 24 hours.. Drug Action(s): The active chemical, gammahydroxybutyrate, naturally occurs in the body. Synthesized, it is odorless, colorless, and only slightly salty, making it practically undetectable in a drink - the normal route of ingestion. GHB inhibits dopamine release in the brain, creating a stockpile which is later released. This provides a sense of well-being after GHB is out of the system.. Acute effects on the mind and body include:. ...
The reaction between 3-aminocrotonates and 3-acetonylideneoxindole in refluxing toluene resulted in 2-pyrrolo-3 -yloxindoles in high yields (around 90%). At room temperature the 2-pyrrolo-3 -yioxindoles exists as keto-enol tautomers. Treatment with POCl3 yielded the 2-chloro-3-pyrrolyl indole, which gave the pyrrolo annulated indolopyran-2-one upon basic hydrolysis of 2-chloro-3-pyrrolyl indole methyl ester.. ...
GHB is a depressant that is a popular drug among young club-goers. It may be abused for its sedative and euphoric effects. Repeated use can lead to addiction
7-Benzyl-3- tert -butyl-1-phenyl-6,7-dihydro-1H,4H -pyrazolo[3,4- d][1,3]oxazine, C22H25N3O, (I), and 3- tert -butyl-7-(4-methylbenzyl)-1-phenyl-6,7-dihydro-1H,4H -pyrazolo[3,4- d][1,3]oxazine, C23H27N3O, (II), are isomorphous in the space group P21, and molecules are linked into chains by C,H...O hydrogen bonds. In each of 3- tert -butyl-7-(4-methoxybenzyl)-1-phenyl-6,7-dihydro-1H,4H -pyrazolo[3,4- d][1,3]oxazine, C23H27N3O2, (III), which has cell dimensions rather similar to those of (I) and (II), also in P21, and 3- tert -butyl-1-phenyl-7-[4-(trifluoromethyl)benzyl]-6,7-dihydro-1H,4H -pyrazolo[3,4- d][1,3]oxazine, C23H24F3N3O, (IV), there are no direction-specific interactions between the molecules. In 3- tert -butyl-7-(4-nitrobenzyl)-1-phenyl-6,7-dihydro-1H,4H -pyrazolo[3,4- d][1,3]oxazine, C22H24N4O3, (V), a combination of C,H...O and C,H...N hydrogen bonds links the molecules into complex sheets. There are no direction-specific interactions between the molecules of 3- tert ...
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​GHB is a central nervous system depressant that causes drowsiness and reduces heart rate. It is used to treat sleep disorders but can be dangerous if misused.
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Benzocycloheptenes. *Azatadine (loratidine minus chlorine atom and ester). References[edit]. *^ a b c d e f g h "Loratadine". ...
Benzocycloheptenes Azatadine See S (2003). "Desloratadine for allergic rhinitis". Am Fam Physician. 68 (10): 2015-6. PMID ...
Benzocycloheptenes Loratadine Katelaris, C. (1990). "Comparative effects of loratadine and azatadine in the treatment of ...
... (SC-27,123) is a tricyclic antidepressant (TCA) that was never marketed.GB 1406481 . Benzocycloheptenes Dictionary ...
Benzocycloheptenes Cyclobenzaprine Tricyclic antidepressant r Ganellin, C; j Triggle, D; MacDonald, F. (1997). Dictionary of ...
Carbamazepine Eslicarbazepine Oxcarbazepine Benzocycloheptenes David J. Triggle (1997). Dictionary of pharmacological agents. ...
Benzocycloheptene Cyproheptadine Ketotifen Stark RJ, Valenti L, Miller GC. Management of migraine in Australian general ... Pizotifen (INN) or pizotyline (USAN), trade name Sandomigran, is a benzocycloheptene-based drug used as a medicine, primarily ...
Benzocycloheptenes Desloratadine (loratidine secondary amine) Azatadine (loratidine minus chlorine atom and ester) "Loratadine ...
... is a tricyclic benzocycloheptene and is closely related to pizotifen and ketotifen as well as to tricyclic ...
Most have two benzene rings, and are called "dibenzocycloheptenes". Some benzocycloheptenes and substituted benzocycloheptenes ... Benzocycloheptenes are cycloheptenes with additional benzene rings attached. ... property of several TCA based molecules Benzocycloheptenes at the US National Library of Medicine Medical Subject Headings ( ...
9-tetrahydro-5H-benzocycloheptene, acetyl terpineol, Aframomum, Alnus-cardamom, alpha-terpinyl acetate, Amomum, Amomum ...
Most have two benzene rings, and are called "dibenzocycloheptenes". Some benzocycloheptenes and substituted benzocycloheptenes ... Benzocycloheptenes are cycloheptenes with additional benzene rings attached. ... property of several TCA based molecules Benzocycloheptenes at the US National Library of Medicine Medical Subject Headings ( ...
Benzocycloheptenes. *Azatadine (loratidine minus chlorine atom and ester). References[edit]. *^ a b c d e f g h "Loratadine". ...
Strategies for Functionalized Benzocycloheptene Amines Synthesis. , 19(2): 179 - 196. Abha Chaudhary and Pralay Das. DOI: ...
Benzocycloheptenes Azatadine See S (2003). "Desloratadine for allergic rhinitis". Am Fam Physician. 68 (10): 2015-6. PMID ...
All MeSH CategoriesChemicals and Drugs CategoryPolycyclic CompoundsPolycyclic Aromatic HydrocarbonsBenzocycloheptenes ... AromaticPolycyclic Aromatic HydrocarbonsBenzocycloheptenesDibenzocycloheptenesDizocilpine Maleate ...
Benzocycloheptenes [D02.455.426.559.847.181]. *Dibenzocycloheptenes [D02.455.426.559.847.181.384]. *Cyproheptadine [D02.455. ...
1H-Benzocycloheptene, 2,4a,5,6,7,8-hexahydro-3,5,5,9-tetramethyl-, (R)- (C15H24) ...
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Benzocycloheptenes and heterocyclic analogues as potential drugs. V. 2-(2-Aminoethyl)-6,7,8,9-tetrahydro-5H-benzocycloheptene ... Benzocycloheptenes and heterocyclic analogues as potential drugs. I. N-Substituted derivatives of 5-amino-6,7,8,9-tetrahydro-5H ... Benzocycloheptenes and heterocyclic analogues as potential drugs. X. Derivatives of 2-amino- and 2-hydroxy-6,7,8,9-tetrahydro-5 ... Benzocycloheptenes and heterocyclic analogues as potential drugs. IX. Amines derived from 2-benzyl-6,7,8,9-tetrahydro-5H- ...
Benzocycloheptene derivatives LU90227I2 (en) 1998-05-13. tazarotene MA20499A1 (en) 1986-04-01. indole derivatives ...
Benzocycloheptene has antioxidant properties that make the compound important for humans and animals ([19], [27]). ... different benzocycloheptene compounds were extracted from untreated and thermo-treated samples with only organic solvents. ...
Benzocycloheptenes and heterocyclic analogues as potential drugs. V. 2-(2-Aminoethyl)-6,7,8,9-tetrahydro-5H-benzocycloheptene ... Benzocycloheptenes and heterocyclic analogues as potential drugs. I. N-Substituted derivatives of 5-amino-6,7,8,9-tetrahydro-5H ... Benzocycloheptenes and heterocyclic analogues as potential drugs. X. Derivatives of 2-amino- and 2-hydroxy-6,7,8,9-tetrahydro-5 ... Benzocycloheptenes and heterocyclic analogues as potential drugs. IX. Amines derived from 2-benzyl-6,7,8,9-tetrahydro-5H- ...
The title compound, C16H25Cl2N, was synthesized from β-himachalene (3,5,5,9-tetra-methyl-2,4a,5,6,7,8-hexa-hydro-1H-benzocyclo- ...
Benzocycloheptene (substance) {438934001 , SNOMED-CT } Parent/Child (Relationship Type) Dibenzocycloheptene (substance) { ...
Sandomigran (pizotifen) is benzocycloheptene-based drug that is often used to treat migraine headaches ...
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files ...
Benzocycloheptenes/therapeutic use*. *Cells, Cultured. *Humans. *Liver Neoplasms/drug therapy. *Liver Neoplasms/genetics ...
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5-cyclo-benzocycloheptene (5), and 3-(3-Butynyl)-2-cycloocten-1- valerenol (6). (14) ...
D04.615.181 Benzocycloheptenes .. D04.615.181.384 Dibenzocycloheptenes .. D04.615.181.384.535 Nortriptyline .. Terms. ... D02.455.426.559.847.181 Benzocycloheptenes .. D02.455.426.559.847.181.384 Dibenzocycloheptenes .. D02.455.426.559.847.181. ...
2-benzocycloheptene (2d), Rehm-Weller equation, 2-methyl-1, 4-benzoquinone, ketonization, fluorescence, UV_vis spectroscopy ... 2-benzocycloheptene (2d), Rehm-Weller equation, 2-methyl-1, 4-benzoquinone, ketonization, fluorescence, UV_vis spectroscopy ...
6,7,8,9-tetrahydro-5H-Benzocycloheptene. 1450666-42-8 1-[(S)-benzosuber-1-yloxycarbonyloxy]ethyl (1R,5S,6S)-2-{[(3S,5S)-5-(N,N- ... 1-benzosuberol; 5H-BENZOCYCLOHEPTEN-5-OL,6,7,8,9-TETRAHYDRO; 5-Hydroxy-6,7,8,9-tetrahydro-5H-benzocycloheptene; 5,6,7,8- ... 5-Hydroxy-6,7,8,9-tetrahydro-5H-benzocycloheptene. 1.3 Recommended use of the chemical and restrictions on use Identified uses ... 6,7,8,9-tetrahydrobenzo[7]annulen-5-one 6,7,8,9-tetrahydro-5H-Benzocycloheptene 1-[(S)-benzosuber-1-yloxycarbonyloxy]ethyl (1R, ...