Benzoates
Oxygenases
Benzoic Acid
Sodium Benzoate
Mixed Function Oxygenases
Widely distributed enzymes that carry out oxidation-reduction reactions in which one atom of the oxygen molecule is incorporated into the organic substrate; the other oxygen atom is reduced and combined with hydrogen ions to form water. They are also known as monooxygenases or hydroxylases. These reactions require two substrates as reductants for each of the two oxygen atoms. There are different classes of monooxygenases depending on the type of hydrogen-providing cosubstrate (COENZYMES) required in the mixed-function oxidation.
Kynurenine 3-Monooxygenase
Methylococcaceae
Methylococcus capsulatus
Biodegradation, Environmental
Benzoate 4-Monooxygenase
Pseudomonas
Cytochrome P-450 Enzyme System
A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.
Parabens
Methylosinus trichosporium
Flavin-Adenine Dinucleotide
Oxidation-Reduction
A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).
Camphor 5-Monooxygenase
A soluble cytochrome P-450 enzyme that catalyzes camphor monooxygenation in the presence of putidaredoxin, putidaredoxin reductase, and molecular oxygen. This enzyme, encoded by the CAMC gene also known as CYP101, has been crystallized from bacteria and the structure is well defined. Under anaerobic conditions, this enzyme reduces the polyhalogenated compounds bound at the camphor-binding site.
Methane
Pseudomonas putida
Nitrosomonas
Hydroxybenzoates
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Alkane 1-Monooxygenase
Hydroxylation
Benzydamine
Azoarcus
Oxidoreductases
The class of all enzymes catalyzing oxidoreduction reactions. The substrate that is oxidized is regarded as a hydrogen donor. The systematic name is based on donor:acceptor oxidoreductase. The recommended name will be dehydrogenase, wherever this is possible; as an alternative, reductase can be used. Oxidase is only used in cases where O2 is the acceptor. (Enzyme Nomenclature, 1992, p9)
Tyrosine 3-Monooxygenase
Hydrocarbons, Aromatic
Squalene Monooxygenase
The second enzyme in the committed pathway for CHOLESTEROL biosynthesis, this enzyme catalyzes the first oxygenation step in the biosynthesis of STEROLS and is thought to be a rate limiting enzyme in this pathway. Specifically, this enzyme catalyzes the conversion of SQUALENE to (S)-squalene-2,3-epoxide.
Substrate Specificity
FMN Reductase
NADPH-Ferrihemoprotein Reductase
Anaerobiosis
Amidine-Lyases
Estradiol
Multienzyme Complexes
Flavins
Dioxygenases
Crotonates
Trichloroethylene
Xylenes
A family of isomeric, colorless aromatic hydrocarbon liquids, that contain the general formula C6H4(CH3)2. They are produced by the destructive distillation of coal or by the catalytic reforming of petroleum naphthenic fractions. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Deltaproteobacteria
Microsomes, Liver
Catalysis
Methylocystaceae
Catechol 1,2-Dioxygenase
Amino Acid Sequence
Gram-Negative Aerobic Bacteria
Beijerinckiaceae
Rhodopseudomonas
Cloning, Molecular
Ammonia
Thauera
Alkanes
NADP
Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
Oxidoreductases, O-Demethylating
Ivermectin
A mixture of mostly avermectin H2B1a (RN 71827-03-7) with some avermectin H2B1b (RN 70209-81-3), which are macrolides from STREPTOMYCES avermitilis. It binds glutamate-gated chloride channel to cause increased permeability and hyperpolarization of nerve and muscle cells. It also interacts with other CHLORIDE CHANNELS. It is a broad spectrum antiparasitic that is active against microfilariae of ONCHOCERCA VOLVULUS but not the adult form.
7-Alkoxycoumarin O-Dealkylase
Pseudomonas mendocina
Alkenes
Oxygen
Multigene Family
A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)
Salicylanilides
Acinetobacter
Biotransformation
The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
Dichloroethylenes
Burkholderia
A genus of gram-negative, aerobic, rod-shaped bacteria. Organisms in this genus had originally been classified as members of the PSEUDOMONAS genus but overwhelming biochemical and chemical findings indicated the need to separate them from other Pseudomonas species, and hence, this new genus was created.
Gene Expression Regulation, Bacterial
Spectrophotometry
Enzyme Induction
Base Sequence
Pseudomonas stutzeri
A species of gram-negative bacteria in the genus PSEUDOMONAS, containing multiple genomovars. It is distinguishable from other pseudomonad species by its ability to use MALTOSE and STARCH as sole carbon and energy sources. It can degrade ENVIRONMENTAL POLLUTANTS and has been used as a model organism to study denitrification.
Escherichia coli
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Sequence Analysis, DNA
Acetone
Copper
Chloroquinolinols
8-Hydroxyquinolinols chlorinated on the number 5 and/or 7 carbon atom(s). They are antibacterial, antiprotozoal, and antidiarrheal, especially in amebiasis, and have also been used as antiseborrheics. The compounds are mostly used topically, but have been used also as animal feed additives. They may cause optic and other neuropathies and are most frequently administered in combination with other agents.
Sequence Homology, Amino Acid
Tryptophan Hydroxylase
Epoxy Compounds
Glyceryl Ethers
Flavin Mononucleotide
4-Hydroxybenzoate-3-Monooxygenase
Camphor
Iron
Hydrogen-Ion Concentration
Alcaligenes
Acetates
Alkanesulfonates
Microsomes
Artifactual vesicles formed from the endoplasmic reticulum when cells are disrupted. They are isolated by differential centrifugation and are composed of three structural features: rough vesicles, smooth vesicles, and ribosomes. Numerous enzyme activities are associated with the microsomal fraction. (Glick, Glossary of Biochemistry and Molecular Biology, 1990; from Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
Food Preservatives
Molecular Structure
Progesterone
The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.
Ralstonia
Chromatography, High Pressure Liquid
Models, Chemical
Styrene
Indigo Carmine
Testolactone
Methimazole
Acinetobacter calcoaceticus
Soil Microbiology
NAD
A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
Binding Sites
Hydrocarbons, Chlorinated
ortho-Aminobenzoates
Phenobarbital
Stereoisomerism
Betaproteobacteria
Operon
Styrenes
Cinnamomum zeylanicum
Sulfides
Phenylalanine Hydroxylase
Plasmids
Phenylacetates
Derivatives of phenylacetic acid. Included under this heading are a variety of acid forms, salts, esters, and amides that contain the benzeneacetic acid structure. Note that this class of compounds should not be confused with derivatives of phenyl acetate, which contain the PHENOL ester of ACETIC ACID.
Aryl Hydrocarbon Hydroxylases
A large group of cytochrome P-450 (heme-thiolate) monooxygenases that complex with NAD(P)H-FLAVIN OXIDOREDUCTASE in numerous mixed-function oxidations of aromatic compounds. They catalyze hydroxylation of a broad spectrum of substrates and are important in the metabolism of steroids, drugs, and toxins such as PHENOBARBITAL, carcinogens, and insecticides.
Crystallography, X-Ray
Methanococcaceae
Models, Molecular
Streptomyces
Culture Media
Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.
Methylococcus
Benzene
Toxic, volatile, flammable liquid hydrocarbon byproduct of coal distillation. It is used as an industrial solvent in paints, varnishes, lacquer thinners, gasoline, etc. Benzene causes central nervous system damage acutely and bone marrow damage chronically and is carcinogenic. It was formerly used as parasiticide.
Anthraquinones
Euryarchaeota
Rhodotorula
Liver
Cytochromes b5
Benzyl Alcohols
Biocatalysis
Luteinizing Hormone
A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Luteinizing hormone regulates steroid production by the interstitial cells of the TESTIS and the OVARY. The preovulatory LUTEINIZING HORMONE surge in females induces OVULATION, and subsequent LUTEINIZATION of the follicle. LUTEINIZING HORMONE consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH and FSH), but the beta subunit is unique and confers its biological specificity.
Sequence Alignment
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
Acyl Coenzyme A
Gas Chromatography-Mass Spectrometry
NADH, NADPH Oxidoreductases
A group of oxidoreductases that act on NADH or NADPH. In general, enzymes using NADH or NADPH to reduce a substrate are classified according to the reverse reaction, in which NAD+ or NADP+ is formally regarded as an acceptor. This subclass includes only those enzymes in which some other redox carrier is the acceptor. (Enzyme Nomenclature, 1992, p100) EC 1.6.
Salicylates
Steroid Hydroxylases
Raccoons
Spectrophotometry, Ultraviolet
Carboxylic Acids
Mutation
Gram-Negative Aerobic Rods and Cocci
A group of gram-negative bacteria consisting of rod- and coccus-shaped cells. They are both aerobic (able to grow under an air atmosphere) and microaerophilic (grow better in low concentrations of oxygen) under nitrogen-fixing conditions but, when supplied with a source of fixed nitrogen, they grow as aerobes.
beta-Carotene 15,15'-Monooxygenase
Insecticides
Estrus
Solubility
Catalytic Domain
Benzopyrene Hydroxylase
Nitrosomonas europaea
Phthalic Acids
Ferredoxins
RNA, Ribosomal, 16S
Estrus Synchronization
Methanospirillum
Methylomonas
Hydrolases
Any member of the class of enzymes that catalyze the cleavage of the substrate and the addition of water to the resulting molecules, e.g., ESTERASES, glycosidases (GLYCOSIDE HYDROLASES), lipases, NUCLEOTIDASES, peptidases (PEPTIDE HYDROLASES), and phosphatases (PHOSPHORIC MONOESTER HYDROLASES). EC 3.
Cytochrome P450rm from Rhodotorula minuta catalyzes 4-hydroxylation of benzoate. (1/1)
Rhodotorula minuta, a red yeast, produces a cytochrome P450, tentatively named P450rm, catalyzing the formation of isobutene from isovalerate. We found that P450rm interacted with benzoate and the dissociation constant of P450rm for benzoate was 36 microM. A reconstituted system that consisted of purified P450rm and cytochrome P450 reductase catalyzed the 4-hydroxylation of benzoate in addition to the formation of isobutene; the turnover rate was approximately 40 nmol/min/nmol P450rm. The P450rm-monooxygenase system was specific for benzoate and did not catalyze hydroxylation of other aromatic carboxylates. Since only a benzoate 4-hydroxylase that requires tetrahydropteridine has been isolated to date, P450rm appears to be the first isolated cytochrome P450 that acts as a benzoate 4-hydroxylase. The P450rm-monooxygenase system in microsomes of R. minuta might function in the degradation of L-phenylalanine on the pathway to beta-ketoadipate. (+info)
Rhodotorula minuta as onychomycosis agent in a Chinese patient: first report and literature review - Zhou - 2013 - Mycoses -...
تأثیر تمرینات مقاومتی دایرهای و بیتمرینی پس از آن بر مقادیر پلاسمایی امنتین-1 و ترکیب بدنی دانشجویان دختر دارای اضافهوزن و...
RP Anti Porosity Milk 250ml - Duo Pro
2-Methoxyl-4-amino-5-ethylsulfonyl methyl benzoate - Alfa Chemistry
CYP53 family
2014). "Cytochrome P450 monooxygenase CYP53 family in fungi: comparative structural and evolutionary analysis and its role as a ... The first gene identified in this family is the CYP53A1 from Aspergillus niger encoding the Benzoate 4-monooxygenase (bphA). ... Cytochrome P450, family 53, also known as CYP53, is a cytochrome P450 monooxygenase family in fungi related to hydrocarbon ... Faber BW, van Gorcom RF, Duine JA (October 2001). "Purification and characterization of benzoate-para-hydroxylase, a cytochrome ...
4-Hydroxybenzoic acid
Benzoate 4-monooxygenase is an enzyme that utilizes benzoate, NADPH, H+ and O2 to produce 4-hydroxybenzoate, NADP+ and H2O. ... This enzyme participates in benzoate degradation via coenzyme A (CoA) ligation. It can be found in Klebsiella aerogenes ( ... This enzyme participates in benzoate degradation via hydroxylation and 2,4-dichlorobenzoate degradation. It can be found in ... This enzyme participates in benzoate degradation via hydroxylation and 2,4-dichlorobenzoate degradation. It can be found in ...
P-hydroxybenzoate hydroxylase
... may refer to: Benzoate 4-monooxygenase 4-hydroxybenzoate 3-monooxygenase This set index page ...
List of MeSH codes (D08)
... camphor 5-monooxygenase MeSH D08.811.682.690.708.170.500 - alkane 1-monooxygenase MeSH D08.811.682.690.708.170.915 - steroid ... benzoate 4-monooxygenase MeSH D08.811.682.690.708.125 - catechol oxidase MeSH D08.811.682.690.708.125.500 - monophenol ... monooxygenase MeSH D08.811.682.690.708.392.468 - Linoleoyl-CoA desaturase MeSH D08.811.682.690.708.392.625 - stearoyl-coa ... tyrosine 3-monooxygenase MeSH D08.811.682.732.332 - catalase MeSH D08.811.682.732.360 - chloride peroxidase MeSH D08.811. ...
Benzoate 4-monooxygenase
This enzyme participates in benzoate degradation via hydroxylation and benzoate degradation via coa ligation. It has 3 ... In enzymology, a benzoate 4-monooxygenase (EC 1.14.14.92, Formerly EC 1.14.13.12) is an enzyme that catalyzes the chemical ... The systematic name of this enzyme class is benzoate,NADPH:oxygen oxidoreductase (4-hydroxylating). Other names in common use ... Reddy CC, Vaidyanathan CS (1975). "Purification, properties and induction of a specific benzoate-4-hydroxylase from Aspergillus ...
4-hydroxybenzoate 3-monooxygenase
... is a homodimer with a flavin bound to each monomer. The active site is composed of the flavin ... Gatti DL, Palfey BA, Lah MS, Entsch B, Massey V, Ballou DP, Ludwig ML (October 1994). "The mobile flavin of 4-OH benzoate ... The hydroxylase, 4-hydroxybenzoate 3-monooxygenase, proceeds through a catalytic process that begins with the entrance of NADPH ... The enzyme 4-hydroxybenzoate 3-monooxygenase, also commonly referred to as para-hydroxybenzoate hydroxylase (PHBH), is a ...
3-hydroxybenzoate 4-monooxygenase
This enzyme participates in benzoate degradation via hydroxylation and 2,4-dichlorobenzoate degradation. It employs one ... In enzymology, a 3-hydroxybenzoate 4-monooxygenase (EC 1.14.13.23) is an enzyme that catalyzes the chemical reaction 3- ... Premkumar R, Rao PV, Sreeleela NS, Vaidyanathan CS (1969). "m-Hydroxybenzoic acid 4-hydroxylase from Aspergillus niger". Can. J ... The systematic name of this enzyme class is 3-hydroxybenzoate,NADPH:oxygen oxidoreductase (4-hydroxylating). This enzyme is ...
4-hydroxybenzoate 3-monooxygenase (NAD(P)H)
This enzyme participates in benzoate degradation via hydroxylation and 2,4-dichlorobenzoate degradation. It employs one ... In enzymology, a 4-hydroxybenzoate 3-monooxygenase [NAD(P)H] (EC 1.14.13.33) is an enzyme that catalyzes the chemical reaction ... The systematic name of this enzyme class is 4-hydroxybenzoate,NAD(P)H:oxygen oxidoreductase (3-hydroxylating). Other names in ... Seibold B, Matthes M, Eppink MH, Lingens F, Van Berkel WJ, Muller R (1996). "4-Hydroxybenzoate hydroxylase from Pseudomonas sp ...
Benzoyl-CoA
... benzoyl-CoA 3-monooxygenase, benzoate-CoA ligase, 2alpha-hydroxytaxane 2-O-benzoyltransferase, anthranilate N- ... This intermediate is subsequently converted by a benzophenone 3′-hydroxylase, a cytochrome P450 monooxygenase, leading to the ... Benzoyl-CoA is a molecule implied in the activity of the different enzymes 4-hydroxybenzoyl-CoA reductase, benzoyl-CoA ... formation of 2,3′,4,6-tetrahydroxybenzophenone. Benzoyl-CoA is a substrate of benzoyl-CoA reductase. This enzyme is responsible ...
3-hydroxybenzoate 6-monooxygenase
This enzyme participates in benzoate degradation via hydroxylation. It employs one cofactor, FAD. Groseclose EE, Ribbons DW, ... In enzymology, a 3-hydroxybenzoate 6-monooxygenase (EC 1.14.13.24) is an enzyme that catalyzes the chemical reaction 3- ... hydroxybenzoate + NADH + H+ + O2 ⇌ {\displaystyle \rightleftharpoons } 2,5-dihydroxybenzoate + NAD+ + H2O The 4 substrates of ...
Anthranilate 3-monooxygenase (deaminating)
... benzoate degradation via hydroxylation, carbazole degradation, and nitrogen metabolism. Powlowski JB, Dagley S, Massey V, ... In enzymology, an anthranilate 3-monooxygenase (deaminating) (EC 1.14.13.35) is an enzyme that catalyzes the chemical reaction ... new type of NADPH-linked nonheme iron monooxygenase". J. Bacteriol. 160 (2): 651-5. PMC 214784. PMID 6501219. Biology portal v ... anthranilate + NADPH + H+ + O2 ⇌ {\displaystyle \rightleftharpoons } 2,3-dihydroxybenzoate + NADP+ + NH3 The 4 substrates of ...
Benzoyl-CoA 3-monooxygenase
... some properties and its role in aerobic benzoate oxidation via gentisate in a denitrifying bacterium". Eur. J. Biochem. 227 (1- ... In enzymology, a benzoyl-CoA 3-monooxygenase (EC 1.14.13.58) is an enzyme that catalyzes the chemical reaction: benzoyl-CoA + ... Niemetz R, Altenschmidt U, Brucker S, Fuchs G (1995). "Benzoyl-coenzyme-A 3-monooxygenase, a flavin-dependent hydroxylase ... NADPH + H+ + O2 ⇌ {\displaystyle \rightleftharpoons } 3-hydroxybenzoyl-CoA + NADP+ + H2O The 4 substrates of this enzyme are ...
Mitomycins
Likely via cytochrome P450 monooxygenase or benzoate hydroxylase O-Methylation at C-9a - Likely via SAM dependent ... 6 (4): 251-263. doi:10.1016/S1074-5521(99)80040-4. PMID 10099135. Charpentier X, Kay E, Schneider D, Shuman HA (March 2011). " ... 4 (5): e31. doi:10.1038/emi.2015.31. PMC 5176177. PMID 26954881. Sharma, Bijaya; Brown, Autumn V.; Matluck, Nicole E.; Hu, ... Specifically, the biosynthesis begins with the addition of phosphoenolpyruvate (PEP) to erythrose-4-phosphate (E4P) with a yet ...
4-Hydroxyphenylacetone
First benzoate is ligated to CoASH to form the high-energy benzoyl-CoA thioester. This reaction is catalyzed by the HXM-A and ... Krueger SK, Williams DE (June 2005). "Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and ... "N-oxygenation of amphetamine and methamphetamine by the human flavin-containing monooxygenase (form 3): role in bioactivation ... cytochrome P450 and flavin monooxygenase. ... Amphetamine can also undergo aromatic hydroxylation to p-hydroxyamphetamine. ... ...
Lisdexamfetamine
First benzoate is ligated to CoASH to form the high-energy benzoyl-CoA thioester. This reaction is catalyzed by the HXM-A and ... CYP2D6, dopamine β-hydroxylase (DBH), flavin-containing monooxygenase 3 (FMO3), butyrate-CoA ligase (XM-ligase), and glycine N- ... Krueger SK, Williams DE (June 2005). "Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and ... "N-oxygenation of amphetamine and methamphetamine by the human flavin-containing monooxygenase (form 3): role in bioactivation ...
Phenylacetone
First benzoate is ligated to CoASH to form the high-energy benzoyl-CoA thioester. This reaction is catalyzed by the HXM-A and ... Cite journal requires ,journal= (help) Krueger SK, Williams DE (June 2005). "Mammalian flavin-containing monooxygenases: ... "N-oxygenation of amphetamine and methamphetamine by the human flavin-containing monooxygenase (form 3): role in bioactivation ... cytochrome P450 and flavin monooxygenase. ... Amphetamine can also undergo aromatic hydroxylation to p-hydroxyamphetamine. ... ...
Drug metabolism
Cytochrome P450 monooxygenase system Flavin-containing monooxygenase system Alcohol dehydrogenase and aldehyde dehydrogenase ... First benzoate is ligated to CoASH to form the high-energy benzoyl-CoA thioester. This reaction is catalyzed by the HXM-A and ... The Cytochrome P450 monooxygenase system is the most important pathway in this regard. In general, anything that increases the ... Cytochrome P450 monooxygenase system enzymes can also vary across individuals, with deficiencies occurring in 1 - 30% of people ...
In situ bioremediation
Anaerobic in situ bioremediation often requires a variety of electron donors or acceptors such as benzoate and lactate. Besides ... Syed, Khajamohiddin; Yadav, Jagjit S. (1 November 2012). "P450 monooxygenases (P450ome) of the model white rot fungus ... Retrieved 4 April 2017. Perelo, Louisa Wessels (15 May 2010). "Review: In situ and bioremediation of organic pollutants in ... 38 (4): 339-363. doi:10.3109/1040841X.2012.682050. ISSN 1040-841X. PMC 3567848. PMID 22624627.. ...
Methanol
... methyl benzoate, anisole, peroxyacids, as well as a host of more specialised chemicals. Small amounts of methanol are present ... The catalytic conversion of methane to methanol is effected by enzymes including methane monooxygenases. These enzymes are ... "Mechanistic Studies on the Hydroxylation of Methane by Methane Monooxygenase". Chem. Rev. 103 (6): 2385-2420. doi:10.1021/ ... CH 4 + O 2 + NADPH + H + ⟶ CH 3 OH + H 2 O + NAD + {\displaystyle {\ce {CH4 + O2 + NADPH + H^+ -> CH3OH + H2O + NAD^+}}} Both ...
List of enzymes
Renilla-luciferin 2-monooxygenase EC 1.13.12.5 Cypridina-luciferin 2-monooxygenase EC 1.13.12.6 Firefly luciferase EC 1.13.12.7 ... Benzoate-CoA ligase EC 6.2.1.26: o-succinylbenzoate-CoA ligase EC 6.2.1.27: 4-hydroxybenzoate-CoA ligase EC 6.2.1.28: 3a,7a- ... Watasenia-luciferin 2-monooxygenase EC 1.13.12.8 Oplophorus-luciferin 2-monooxygenase EC 1.13.12.13 Cytochrome P450 oxidase ... internal monooxygenases or internal mixed function oxidases)) ... EC 1.6.4 now Category:EC 1.8.1 Category:EC 1.6.5 (with a ...
List of enzymes
Category:EC 1.13.12 (With incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)) * ... EC 6.2.1.25: Benzoate--CoA ligase. *EC 6.2.1.26: o-succinylbenzoate--CoA ligase ... Category:Lyases (EC 4) (Lyase)Edit. Category:EC 4.1 (carbon-carbon lyases)Edit. *Category:EC 4.1.1 *Ornithine decarboxylase (EC ... Category:EC 1.6.4 now Category:EC 1.8.1. *Category:EC 1.6.5 (with a quinone or similar compound as acceptor) *NADH ...
Dextroamphetamine
First benzoate is ligated to CoASH to form the high-energy benzoyl-CoA thioester. This reaction is catalyzed by the HXM-A and ... CYP2D6, dopamine β-hydroxylase (DBH), flavin-containing monooxygenase 3 (FMO3), butyrate-CoA ligase (XM-ligase), and glycine N- ... Krueger SK, Williams DE (June 2005). "Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and ... "N-oxygenation of amphetamine and methamphetamine by the human flavin-containing monooxygenase (form 3): role in bioactivation ...
Benzoate 4-monooxygenase - Wikipedia
This enzyme participates in benzoate degradation via hydroxylation and benzoate degradation via coa ligation. It has 3 ... In enzymology, a benzoate 4-monooxygenase (EC 1.14.14.92, Formerly EC 1.14.13.12) is an enzyme that catalyzes the chemical ... The systematic name of this enzyme class is benzoate,NADPH:oxygen oxidoreductase (4-hydroxylating). Other names in common use ... Reddy CC, Vaidyanathan CS (1975). "Purification, properties and induction of a specific benzoate-4-hydroxylase from Aspergillus ...
TNO Repository search for: subject:'Oxygenase'
Cell extracts contained both (1R)-(iso-)dihydrocarvone 1,2-monooxygenase and (1S)-(iso)-dihydrocarvone 2,3-monooxygenase ... Regulation of expression of the Aspergillus niger benzoate para-hydroxylase cytochrome P450 system article. 2000 ... NADPH-dependent dihydrocarvone monooxygenase (Baeyer-Villiger monooxygenase), ε-lactone hydrolase and an NAD+-dependent 6- ... Chemicals/CAS: benzoate 4-monooxygenase, EC 1.14.13.12; Benzoates; biphenyl-2,3-dioxygenase, EC 1.14.99.-; Mixed Function ...
CYP53 family - Wikipedia
2014). "Cytochrome P450 monooxygenase CYP53 family in fungi: comparative structural and evolutionary analysis and its role as a ... The first gene identified in this family is the CYP53A1 from Aspergillus niger encoding the Benzoate 4-monooxygenase (bphA). ... Cytochrome P450, family 53, also known as CYP53, is a cytochrome P450 monooxygenase family in fungi related to hydrocarbon ... Faber BW, van Gorcom RF, Duine JA (October 2001). "Purification and characterization of benzoate-para-hydroxylase, a cytochrome ...
Code System Concept
Argentilactone Molecular Targets in Paracoccidioides brasiliensis Identified by Chemoproteomics | Antimicrobial Agents and...
... benzoate 4-monooxygenase cytochrome P450 (BMC), ABC multidrug transporter (ABC), and trichothecene efflux pump (TEP). The ... 4). A similar result was observed for thioridazine (50) and oenotein B (38), compounds that inhibit the growth of P. ... FIG 4 Quantification of cell wall polymers from P. brasiliensis. The levels of total carbohydrates, N-acetylglucosamine, and β- ... The cells then were centrifuged and washed with phosphate-buffered saline (0.09% Na2HPO4, 0.02% KH2PO4, 0.8% NaCl, 0.02% KCl, ...
DeCS
Benzoate 4-Monooxygenase - Preferred Concept UI. M0072598. Scope note. An enzyme that catalyzes the oxidation of BENZOATE to 4- ... Tyrosine 3 Monooxygenase [D08.811.682.690.708.923] Tyrosine 3 Monooxygenase * Vitamin K Epoxide Reductases [D08.811.682.690. ... Benzoate Benzoate 4 Hydroxylase Benzoate 4 Monooxygenase Benzoate 4-Hydroxylase Benzoate Para Hydroxylase Benzoate-Para- ... Benzoate. Benzoate 4 Hydroxylase. Benzoate 4 Monooxygenase. Benzoate 4-Hydroxylase. Benzoate Para Hydroxylase. Benzoate-Para- ...
DeCS Ingl s+escopo
Benzoate Para Hydroxylase .. An enzyme that catalyzes the oxidation of BENZOATE to 4-hydroxybenzoate. It requires IRON and ... Benzoate 4-Monooxygenase .. Benzoate 4-Hydroxylase .. Benzoate-Para-Hydroxylase .. 4-Hydroxylase, Benzoate .. 4-Monooxygenase, ... D08.811.682.690.708.062 Benzoate 4-Monooxygenase .. D08.811.682.690.708.826 Trans-Cinnamate 4-Monooxygenase .. ... Trans Cinnamate 4 Monooxygenase .. Trans Cinnamate 4 Monooxygenase CYP73 .. Trans Cinnamic Acid 4 Hydroxylase .. A member of ...
The genomic study of an environmental isolate of Scedosporium apiospermum shows its metabolic potential to degrade hydrocarbons...
Vatsyayan P, Kamur AK, Goswami P, Goswami P. Broad substrate cytochrome P450 monooxygenase activity in the cells of Aspergillus ... Most of the genes were mapped to the benzoate and its derivate compounds as aminobenzoate and fluorobenzoate ... Disruption of phacA, an Aspergillus nidulans gene encoding a novel cytochrome P450 monooxygenase catalyzing phenylacetate 2- ... Sheng D, Ballou DP, Massey V. Mechanistic studies of cyclohexanone monooxygenase: chemical properties of intermediates involved ...
ENZYME: 1.14.13.
Phenol 2-monooxygenase (NADPH) 1.14.13.8 Flavin-containing monooxygenase 1.14.13.9 Kynurenine 3-monooxygenase 1.14.13.10 2,6- ... Benzoate 4-monooxygenase 1.14.13.13 Transferred entry: 1.14.15.18 1.14.13.14 Trans-cinnamate 2-monooxygenase 1.14.13.15 ... Dihydrochelirubine 12-monooxygenase 1.14.13.58 Benzoyl-CoA 3-monooxygenase 1.14.13.59 L-lysine N(6)-monooxygenase (NADPH) 1.14. ... 5-monooxygenase 1.14.13.224 Violacein synthase 1.14.13.225 F-actin monooxygenase 1.14.13.226 Acetone monooxygenase (methyl ...
Fatty Acid Desaturases | Harvard Catalyst Profiles | Harvard Catalyst
Kynurenine 3-Monooxygenase. *Phenylalanine Hydroxylase. *Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase. *Procollagen-Proline ... Benzoate 4-Monooxygenase. *Catechol Oxidase. *Cytochrome P-450 Enzyme System. *Dopamine beta-Hydroxylase ... Influence of toll-like receptor 4 gene variants and plasma fatty acid profile on systemic inflammation: A population-based ...
gamma-Butyrobetaine Dioxygenase | Harvard Catalyst Profiles | Harvard Catalyst
2-Oxoquinoline 8-monooxygenase oxygenase component: active site modulation by Rieske-[2Fe-2S] center oxidation/reduction. -...
The crystal structure of the oxygenase component of 2-oxoquinoline 8-monooxygenase shows a ring-shaped, C3-symmetric ... 2-Oxoquinoline 8-monooxygenase is a Rieske non-heme iron oxygenase that catalyzes the NADH-dependent oxidation of the N- ... Rate-Determining Attack on Substrate Precedes Rieske Cluster Oxidation during Cis-Dihydroxylation by Benzoate Dioxygenase.. * ... Dicamba monooxygenase: structural insights into a dynamic Rieske oxygenase that catalyzes an exocyclic monooxygenation.. * ...
Availability of O2 as a Substrate in the Cytoplasm of Bacteria under Aerobic and Microaerobic Conditions | Journal of...
A) Growth with benzoate in the oxystat at different pO2 values. Growth was performed in the mineral medium with 10 mM benzoate ... The rate of O2 consumption by the oxygenases in the cell interior (νO2in) is twice the rate of benzoate metabolism (νbenzoate ... The O2 consumption by the dioxygenases was calculated from μ and from the molar growth yield on benzoate (Ybenzoate) under the ... Catechol is an intermediate of the ortho cleavage pathway of benzoate. Up to 0.65 mol of catechol per mol of benzoate was ...
Published Research | Page 9 | BIO5
A benzoate-coenzyme A ligase from Rhodopseudomonas palustris was also included in some constructs. Fermentations with the ... The cytochrome P450 monooxygenase Ema1 from Streptomyces tubercidicus R-922 and its homologs from closely related Streptomyces ... lividans strains in the presence of benzoate and/or cinnamate yielded soraphen A. Further feeding experiments were used to ... cytochrome P450 mono-oxygenases). The genes for these enzymes have been cloned, sequenced and compared to reveal a new ...
EC 1.14.14
... 38 valine N-monooxygenase. EC 1.14.14.39 isoleucine N-monooxygenase. EC 1.14.14.40 phenylalanine N-monooxygenase. EC ... EC 1.14.14.92 benzoate 4-monooxygenase. EC 1.14.14.93 3,9-dihydroxypterocarpan 6a-monooxygenase. EC 1.14.14.94 leukotriene-B4 ... monooxygenase. EC 1.14.14.16 steroid 21-monooxygenase. EC 1.14.14.17 squalene monooxygenase. EC 1.14.14.18 heme oxygenase ( ... monooxygenase. EC 1.14.14.97 methyltetrahydroprotoberberine 14-monooxygenase. EC 1.14.14.98 protopine 6-monooxygenase. EC 1.14. ...
Catechol Oxidase | Profiles RNS
Biology | Free Full-Text | Structural Organization of Enzymes of the Phenylacetate Catabolic Hybrid Pathway
We discuss the ability of the central PaaABCE monooxygenase to reversibly oxygenate PA, the controlling mechanisms of epoxide ... concentration by the pathway enzymes, and the similarity of the PA utilization pathway to the benzoate utilization Box pathway ... We discuss the ability of the central PaaABCE monooxygenase to reversibly oxygenate PA, the controlling mechanisms of epoxide ... 2015; 4(2):424-442. Chicago/Turabian Style. Grishin, Andrey M.; Cygler, Miroslaw. 2015. "Structural Organization of Enzymes of ...
PROSITE
The N-terminal domain of the bifunctional ferredoxin/ferredoxin reductase electron transfer component of the benzoate 1,2- ... The N-terminal domain of methane monooxygenase component C (gene mmoC) from Methylococcus capsulatus . ... The N-terminal domain of CDP-6-deoxy-3,4-glucoseen reductase (gene ascD) from Yersinia pseudotuberculosis. ... 4]. The two Fe atoms are coordinated tetrahedrally by the two inorganic S atoms and four cysteinyl S atoms. ...
Biotech report | Biology homework help
Functions Required for Extracellular Quinolone Signaling by Pseudomonas aeruginosa | Journal of Bacteriology
Gene pqsH encodes a putative FAD-dependent monooxygenase that may be responsible for the addition of the hydroxyl group to PQS. ... Gene pqsA encodes a product homologous to benzoate coenzyme A ligase, which may be involved in activating anthranilate for PQS ... 4. PQS synthesis and regulation. The genomic organization of the pqs genes and a model for PQS biosynthesis and regulation are ... 3 and Table 5). phnA and phnB encode an anthranilate synthase (10), and anthranilate is a precursor of PQS (4). Since there are ...
Detection of Genes Involved in Biodegradation and Biotransformation in Microbial Communities by Using 50-Mer Oligonucleotide...
Genomic DNA of Rhodopseudomonas palustris (α-proteobacterium; anaerobic toluene, phenol, and benzoate degrader) was a gift of C ... and alkane monooxygenase) (3, 31, 34, 50). Thus, the developed microarray should be useful for assessing possible horizontal ... The genes involved in anaerobic benzoate degradation (4-hydroxylbenzoyl-coenzyme A [CoA] reductase, 3-hydroxylbenzoate CoA ... and benzoate degrader) used in this study were obtained from the American Type Culture Collection and the German Collection of ...
KEGG ENZYME: 1.14.13.33
4-hydroxybenzoate [CPD:C00156];. NADH [CPD:C00004];. NADPH [CPD:C00005];. H+ [CPD:C00080];. O2 [CPD:C00007]. ... 3,4-dihydroxybenzoate [CPD:C00230];. NAD+ [CPD:C00003];. NADP+ [CPD:C00006];. H2O [CPD:C00001]. ... 4-hydroxybenzoate + NAD(P)H + H+ + O2 = 3,4-dihydroxybenzoate + NAD(P)+ + H2O [RN:R01296 R01298]. ... 4-hydroxybenzoate 3-monooxygenase [NAD(P)H];. 4-hydroxybenzoate 3-monooxygenase (reduced nicotinamide adenine dinucleotide ( ...
Pesquisa | Portal Regional da BVS
p-Hydroxybenzoate hydroxylase (PHBH) is a flavoprotein monooxygenase that catalyzes the hydroxylation of p-hydroxybenzoate (p- ... PHBH can bind to other benzoate derivatives in addition to p-OHB; however, hydroxylation does not occur on 3,4-DOHB. ... Peptidoglycan (PG) is a critical component of the bacterial cell wall and is composed of a repeating ß-1,4-linked disaccharide ... 4-Hidroxibenzoato-3-Mono-Oxigenase/metabolismo , Proteínas de Bactérias/metabolismo , Ácido Gálico/metabolismo , Pseudomonas ...
New insights into the genome of Rhodococcus ruber strain Chol-4 | BMC Genomics | Full Text
In this work, the genome of R. ruber strain Chol-4 has been re-sequenced, revised, annotated and compared to other bacterial ... Rhodococcus ruber strain Chol-4, a strain isolated from a sewage sludge sample, is able to grow in minimal medium supplemented ... The genomic analysis and experimental data presented in this work confirm the metabolic potential of R. ruber strain Chol-4. ... The analysis of the data suggests that R. ruber Chol-4 contains several putative metabolic clusters of biotechnological ...
Recent Developments in Using Advanced Sequencing Technologies for the Genomic Studies of Lignin and Cellulose Degrading...
The draft genome sequence of strain MBES04 showed the existence of benzoate degrading gene cluster and also genes coding for ... YS-1r strain also codes for enzymes like phenol 2 monooxygenase, 4-hydroxybenzoate-3-monooxygenase, catechol-2,3-dioxygenase, ... Enzymes involved in aromatic ring oxidation and cleavage such as phenol 2-monooxygenase, 4-hydroxybenzoate 3-monooxygenase, ... the genes involved in the aromatic compound degradation such as p-hydroxybenzoate 3-monooxygenase and vanillate monooxygenase. ...
Frontiers | Physicochemical characteristics of structurally determined metabolite-protein and drug-protein binding events with...
In fact, BZS is described as an intermediate in benzoate degradation, which can be converted to benzylsuccinyl-CoA via the ... 1998). Mutations of the flavin-containing monooxygenase gene (FMO3) cause trimethylaminuria, a defect in detoxication. Hum. Mol ... an oxidation product of trimethylamine catalyzed by the enzyme dimethylaniline monooxygenase (Treacy et al., 1998) (EC 1), ... 4. −. ), solvents (e.g., water, MES, DMSO, 2-mercaptanol, glycerol), chemical fragments or clusters were removed from the ...
Frontiers | Metagenomic Analysis of Hot Springs in Central India Reveals Hydrocarbon Degrading Thermophiles and Pathways...
Genes associated with hydrocarbon degradation pathways, such as benzoate, xylene, toluene, and benzene were observed to be ... Genes associated with hydrocarbon degradation pathways, such as benzoate, xylene, toluene, and benzene were observed to be ... A pathway map of benzoate degradation showing the observed KOs (highlighted in red) in this dataset. Benzoate is degraded and ... Methane is oxidized to methanol via methane monooxygenase and converted to formaldehyde with the help of methanol dehydrogenase ...
Rhodococcus pyridinivorans - microbewiki
3). A benzothiazole (BT) is first hydroxylated by a monooxygenase, producing 2-hydroxybenzothiazole (OBT). OBT is also ... benzoate 1,2-dioxygenase, 3-ketosteroid-9α-hydroxylase, 3-ketosteroid-σ-dehydrogenase, and so on. Some of these enzymes seem to ... 4.Gary Ginsberg, Brian Toal & Tara Kurland. 2011. Bezothialzole Toxicity Assessment in Support of Synthetic Turf Field Human ... Glycosyl is present as the acyl type in the beta-1,4-N acetylmuramic acid. These distinctive chemotaxonomic markers have ...
Lawrence M Schopfer, PhD - Research Output
- Research Nebraska
DeCS
Dopamine beta-monooxygenase Entry term(s):. Dopamine beta Hydroxylase. Dopamine beta Monooxygenase. Dopamine beta-Monooxygenase ... Dopamine beta Monooxygenase Dopamine beta-Monooxygenase beta-Hydroxylase, Dopamine beta-Monooxygenase, Dopamine ... Benzoate 4 Monooxygenase [D08.811.682.690.708.062] Benzoate 4 Monooxygenase * Catechol Oxidase [D08.811.682.690.708.125] + ... 3,4-Dihydroxyphenethylamine, ascorbate:oxygen oxidoreductase (beta-hydroxylating) Previous Indexing:. Hydroxylases (1966-1970) ...
HydroxylaseDegradationProtocatechuate-3,4-dioxygenaseCytochromePseudomonasBaeyer-VilligerCleavageToluene 4-monooxygenasePathwayHydrolaseNADPHEnzymesCatecholMetabolismSubstratesCatabolismPathwaysCyclohexanoneSubstrateAromatic compoundsDioxygenaseFlavinLimoneneEnzyme that catalyzesAcidReductaseOxidationFatty acidsPurificationCatalyzesFungalAspergillusPreferentially1989
Hydroxylase6
- Other names in common use include benzoic acid 4-hydroxylase, benzoate 4-hydroxylase, benzoic 4-hydroxylase, benzoate-p-hydroxylase, and p-hydroxybenzoate hydroxylase. (wikipedia.org)
- 4-Hydroxybenzoate hydroxylase from Pseudomonas sp. (genome.jp)
- The genome sequence of R.pyridinivorans strain AK37 has identified several key enzymes involved in the six pathways of monocyclic aromatic compound biodegradation: protocatechuate 3,4-dioxygenase, benzoate 1,2-dioxygenase, 3-ketosteroid-9α-hydroxylase, 3-ketosteroid-σ-dehydrogenase, and so on. (kenyon.edu)
- pcpD is immediately downstream of pcpB, the gene encoding PCP hydroxylase (PCP monooxygenase). (antievolution.org)
- Based upon the known mechanisms of flavin monooxygenases such as PCP hydroxylase, hydroxylation of PCP should produce tetrachlorobenzoquinone, while hydroxylation of tetrachlorophenol should produce tetrachlorohydroquinone. (antievolution.org)
- We have chosen to emphasize in this section the enzyme p -hydroxybenzoate hydroxylase, because it has been the outstanding model for the chemistry of these enzymes (3, 4) and has been studied extensively. (schoolbag.info)
Degradation15
- This enzyme participates in benzoate degradation via hydroxylation and benzoate degradation via coa ligation. (wikipedia.org)
- Dihydro)carveol-grown cells of R. erythropolis DCL14 contained the following enzymic activities involved in the carveol and dihydrocarveol degradation pathways of this micro-organism: (dihydro)carveol dehydrogenase (both NAD+- and dichlorophenolindophenol-dependent activities), an unknown cofactor-dependent carvone reductase, (iso-)dihydrocarvone isomerase activity, NADPH-dependent dihydrocarvone monooxygenase (Baeyer-Villiger monooxygenase), ε-lactone hydrolase and an NAD+-dependent 6-hydroxy-3-isopropenylheptanoate dehydrogenase. (tudelft.nl)
- Product accumulation studies identified (4R)-carvone, (1R,4R)-dihydrocarvone, (4R,7R)-4-isopropenyl-7-methyl-2-oxo-oxepanone, (3R)-6-hydroxy-3-isopropenylheptanoate, (3R)-3-isopropenyl -6-oxoheptanoate, (3S,6R)-6-isopropenyl-3-methyl-2-oxo-oxepanone and (5R)-6-hydroxy-5-isopropenyl-2-methylhexanoate as intermediates in the (4R)carveol degradation pathway. (tudelft.nl)
- For the degradation of aromatic compounds like benzoate, oxygenases are required for oxidative cleavage of the aromatic ring ( 7 , 10 ). (asm.org)
- The results indicate that P. cepacia ATCC 29351 possesses the genetic capacity for enzymes of both the ortho- and meta -cleavage pathways of benzoate degradation, although the phenotypic expression for the ortho pathway is higher. (springer.com)
- In the presence of benzoate, 4-hydroxybenzoic acid, 3,4-dihydroxybenzoic acid or vanillic acid as growth substrates, the degradation of 21.5 %, 71.71 %, 14.7 5% and 8.16 % of naproxen was observed respectively. (pjmonline.org)
- The obtained results suggest that monooxygenase and hydroxyquinol 1,2-dioxygenase are the main enzymes in naproxen degradation by Planococcus sp. (pjmonline.org)
- 2006). Plasmid pRHL3 was predicted to contain three P450 monooxygenase genes, as well as a gene cluster coding for putative aromatic ring dioxygenase, dehydrogenase, and intradiol dioxygenase enzymes that may be involved in oxidation and degradation of aromatic compounds (RHL3.277-3.281). (alpfmedical.info)
- Fig. 4 Aerobic bacterial degradation of biphenyl ( http://umbbd.msi.umn.edu/ ). (alpfmedical.info)
- Apart from quinaldine utilization, strain Rue61a has a limited set of aromatic degradation pathways, enabling the utilization of 4-hydroxy-substituted aromatic carboxylic acids, which are characteristic products of lignin depolymerization, via ortho cleavage of protocatechuate. (biomedcentral.com)
- However, 4-hydroxyphenylacetate degradation likely proceeds via meta cleavage of homoprotocatechuate. (biomedcentral.com)
- Most of the 2,4-D plasmids were found in strains isolated by enrichment on 2,4-D as the sole source of carbon and energy, and some of them were found to take part in the degradation of a herbicide with a similar structure, 2-methyI-4-chlorophenoxyacetic acid. (asmscience.org)
- 3- and 4-alkylphenol degradation pathway in Pseudomonas sp. (microbiologyresearch.org)
- Degradation of 4-amylphenol and 4-hexylphenol by a new activated sludge isolate of Pseudomonas veronii and proposal for a new subspecies status. (microbiologyresearch.org)
- An inducible propane monooxygenase is responsible for N-nitrosodimethylamine degradation by Rhodococcus sp. (ubc.ca)
Protocatechuate-3,4-dioxygenase2
- Pseudomonas putida KT2442 degrades benzoate by benzoate-1,2-dioxygenase and catechol-1,2-dioxygenase ( ortho pathway), whereas 4-hydroxybenzoate is degraded via 4-hydroxybenzoate monooxygenase and protocatechuate-3,4-dioxygenase ( ortho cleavage). (asm.org)
- It was shown that the activity of monooxygenase, hydroxyquinol 1,2-dioxygenase, protocatechuate 3,4-dioxygenase and protocatechuate 4,5-dioxyegnase in strain S5 was induced after growth of the strain with naproxen and 4-hydroxybenzoate. (pjmonline.org)
Cytochrome5
- Cytochrome P450, family 53, also known as CYP53, is a cytochrome P450 monooxygenase family in fungi related to hydrocarbon assimilation. (wikipedia.org)
- In fungi, lanosterol 14- α -demethylase (CYP51) belongs to a superfamily of monooxygenases called cytochrome P450, which catalyzes the oxidative removal of the 14-methyl group (C-32) of lanosterol to give 14,15-desaturated intermediates in ergosterol biosynthesis. (hindawi.com)
- One such group of enzymes include the cytochrome P450 monooxygenases. (medcraveonline.com)
- The levels of cytochrome P-450 and related monooxygenases, viz. (bvsalud.org)
- While the cytochrome P450 monooxygenases (CYP) from the CYP79 family forming aldoximes as biosynthetic intermediates have been intensively studied, little is known about the enzymology of volatile aldoxime formation. (plantcell.org)
Pseudomonas9
- 2-Oxoquinoline 8-monooxygenase is a Rieske non-heme iron oxygenase that catalyzes the NADH-dependent oxidation of the N-heterocyclic aromatic compound 2-oxoquinoline to 8-hydroxy-2-oxoquinoline in the soil bacterium Pseudomonas putida 86. (semanticscholar.org)
- The growth rates of Pseudomonas putida KT2442 and mt-2 on benzoate, 4-hydroxybenzoate, or 4-methylbenzoate showed an exponential decrease with decreasing oxygen tensions (partial O 2 tension [pO 2 ] values). (asm.org)
- The N-terminal domain of the bifunctional ferredoxin/ferredoxin reductase electron transfer component of the benzoate 1,2-dioxygenase complex (gene benC) from Acinetobacter calcoaceticus, the toluene 4-monooxygenase complex (gene tmoF), the toluate 1,2-dioxygenase system (gene xylZ), and the xylene monooxygenase system (gene xylA) from Pseudomonas. (expasy.org)
- Recently, a third signaling system based on 2-heptyl-3-hydroxy-4-quinolone, designated the Pseudomonas quinolone signal (PQS), has been shown to be a part of the quorum-sensing regulatory network in P. aeruginosa ( 27 ). (asm.org)
- This work demonstrates the ring-cleavage pathways of catechol on Pseudomonas cepacia ATCC 29351, formed upon its growth on salicylate and benzoate, each as a sole carbon source. (springer.com)
- Feist CF, Hegeman GD (1969b) Regulation of the meta cleavage pathway for benzoate oxidation by Pseudomonas putida . (springer.com)
- Burkholderia cepacia G4, Ralstonia pickettii PKO1, and Pseudomonas mendocina KR1 first oxidize toluene using specific monooxygenases to form o -, m -, and p -cresol, respectively ( 34 , 35 , 52 ). (asm.org)
- On the other hand, Pseudomonas putida mt-2 oxidizes the methyl group of toluene to form benzoic acid, which is further metabolized through a meta cleavage pathway via catechol ( 4 ). (asm.org)
- The bacterial strains B. megaterium (SO5-4 and SO6-2) and Pseudomonas sp. (bvsalud.org)
Baeyer-Villiger1
- A method for rapid screening of ketone biotransformations: detection of whole cell Baeyer-Villiger monooxygenase activity. (augmentin2020.site)
Cleavage3
- 4-Methylbenzoate is metabolized by P. putida mt-2 by toluate-1,2-dioxygenase and catechol-2,3-dioxygenase ( meta cleavage) ( 5 , 8 ). (asm.org)
- In strain KR1, the methyl group of p -cresol is oxidized, and the resulting 4-hydroxybenzoate is degraded by an ortho cleavage pathway ( 51 ). (asm.org)
- C23O preferentially oxidizes 4-alkylcatechols via proximal (2,3) cleavage. (microbiologyresearch.org)
Toluene 4-monooxygenase1
- The I100V isoform of toluene-4-monooxygenase was used to catalyze the oxidative polymerization of anthranil and various indoles under mildly acidic conditions, favoring the production of trimers. (springeropen.com)
Pathway2
- We discuss the ability of the central PaaABCE monooxygenase to reversibly oxygenate PA, the controlling mechanisms of epoxide concentration by the pathway enzymes, and the similarity of the PA utilization pathway to the benzoate utilization Box pathway and β-oxidation of fatty acids. (mdpi.com)
- Although catechol is the metabolic intermediate for both salicylate and benzoate, catechol did not induce either pathway when used as a sole carbon source. (springer.com)
Hydrolase2
- Therefore, this study aimed to determine the enzymatic activities (esterase, epoxide hydrolase and monooxygenase) of 56 heterotrophic bacteria isolated from a neutral copper mine drainage (Sossego Mine, Canaã dos Carajás, Brazil). (bvsalud.org)
- Hydrolase and monooxygenase activities were detected in 75% and 20% of the evaluated bacteria, respectively. (bvsalud.org)
NADPH3
- In enzymology, a benzoate 4-monooxygenase (EC 1.14.14.92, Formerly EC 1.14.13.12) is an enzyme that catalyzes the chemical reaction benzoate + NADPH + H+ + O2 ⇌ {\displaystyle \rightleftharpoons } 4-hydroxybenzoate + NADP+ + H2O The 4 substrates of this enzyme are benzoate, NADPH, H+, and O2, whereas its 3 products are 4-hydroxybenzoate, NADP+, and H2O. (wikipedia.org)
- The systematic name of this enzyme class is benzoate,NADPH:oxygen oxidoreductase (4-hydroxylating). (wikipedia.org)
- The enzyme from Corynebacterium cyclohexanicum is highly specific for 4-hydroxybenzoate, but uses NADH and NADPH at approximately equal rates (cf. (genome.jp)
Enzymes1
- Both enzymes have been characterized as 2-hydroxy-6-oxohepta-2,4-dienoate hydrolases with low activity toward 2-hydroxy-6-oxophenylhexa-2,4-dienoate (the substrate of BphD), but EtbD2 and EtbD1 convert the latter compound with 11 and 3.3% relative activity, respectively (Yamada et al. (alpfmedical.info)
Catechol1
- However, interestingly, benzoate-grown cells induce the ortho and meta pathways for the biodegradation of catechol, by inducing simultaneously catechol 1,2-dioxygenase and 2,3-dioxygenase, respectively, in the ratio of 7:1. (springer.com)
Metabolism1
- Moreover, in the presence of naproxen activity of gentisate 1,2-dioxygenase, enzyme engaged in 4-hydroxybenzoate metabolism, was completely inhibited. (pjmonline.org)
Substrates2
- WUE TAN, E. Direct spectrophotometric assay of monooxygenase and oxidase activities of mushroom tyrosinase in the presence of synthetic and natural substrates. (blucher.com.br)
- The latter is known to be functionally associated with C23O for use of 4-alkylcatechols as substrates. (microbiologyresearch.org)
Catabolism3
- Gene clusters putatively involved in aromatic compounds catabolism identified in R. ruber Chol-4 and its comparison with R. jostii RHA1. (biomedcentral.com)
- Assimilation of arom atic compounds likely relies on phc ARKLMNOPQ gene cluster for phenol, benzene and toluene catabolism, and on benRABCDKGEF cluster for benzoate catabolism. (scirp.org)
- 2010. A flavin-dependent monooxygenase from mycobacterium tuberculosis involved in cholesterol catabolism. (ubc.ca)
Pathways1
- Akaterpin ( 25 ) inhibits hydrolysis of phosphatidylinositol by phospholipase C, a key step in eukaryotic signaling pathways by its production of diacylglycerol and inositol triphosphate [ 4 ]. (mdpi.com)
Cyclohexanone1
- Purified cyclohexanone monooxygenase is a versatile oxygenation catalyst. (mfrbee.com)
Substrate2
- Rate-Determining Attack on Substrate Precedes Rieske Cluster Oxidation during Cis-Dihydroxylation by Benzoate Dioxygenase. (semanticscholar.org)
- Substrate specificity studies show that mPH preferentially oxidizes 3- and 4-alkylphenols to 4-alkylcatechols. (microbiologyresearch.org)
Aromatic compounds1
- Strain RHA1 besides biphenyl (Fig. 4) utilizes isopropylbenzene, ethyl-benzene, and other monocyclic aromatic compounds (Gon^alves et al. (alpfmedical.info)
Dioxygenase1
- 2014). After growth of strain KB2 on naproxen activity of phenol monooxygenase, naphthalene dioxygenase, hydroxyquinol 1,2-dioxygenase and gentisate 1,2-dioxygenase was observed. (pjmonline.org)
Flavin1
- Massey V, Hemmerich P (1975) Flavin and pteridine monooxygenases. (springer.com)
Limonene1
- Two ORFs (RHL3.41 and RHL3.42) presumed to encode a carveol dehydrogenase and a limonene monooxygenase are clustered together with a series of dehydro-genase genes. (alpfmedical.info)
Enzyme that catalyzes1
- An enzyme that catalyzes the oxidation of BENZOATE to 4-hydroxybenzoate. (bvsalud.org)
Acid3
- Glycosyl is present as the acyl type in the beta-1,4-N acetylmuramic acid. (kenyon.edu)
- Sialic acids are O-acetylated at diverse positions by the action of acetyl-CoA-4-O- and -7-O-acetyltransferases found in various animals and, leading to the O-acetylation of sialic acid glycerol side chain, also in man. (bvsalud.org)
- An investigation of the rate of birth malformations in the Northland region of New Zealand provides no evidence to associate spraying of 2,4,5-trichlorophenoxyacetic acid with the occurrence of any malformation of the central nervous system, including spina bifida. (augmentin2020.site)
Reductase1
- The N-terminal domain of CDP-6-deoxy-3,4-glucoseen reductase (gene ascD) from Yersinia pseudotuberculosis. (expasy.org)
Oxidation1
- 2-Oxoquinoline 8-monooxygenase oxygenase component: active site modulation by Rieske-[2Fe-2S] center oxidation/reduction. (semanticscholar.org)
Fatty acids2
- Fungal CYP monooxygenases, FoCYP539A7 and FoCYP655C2 with its homologous redox partner, FoCPR constitutes a promising catalyst due to its high regio- and stereo-selectivity in the hydroxylation of fatty acids and in the substantial production of industrially valuable ω-hydroxy fatty acids. (biomedcentral.com)
- However, the terminal oxygenation of saturated or unsaturated fatty acids for the synthesis of ω-OHFAs is intricate to accomplish through chemo catalysis, due to the selectivity and controlled reactivity in C-H oxygenation reactions [ 4 ]. (biomedcentral.com)
Purification1
- Regulation and Enforcement of Legislation on Food Safety in NigeriaBy Jane Omojokun13323Edited Purification and products make used hydrolysis a strategy of the Edited VolumeIntechOpenMycotoxin and Food Safety in treating CountriesEdited by Hussaini MakunFree monooxygenase with DHL ExpressHardcover( ex. (website.pl)
Catalyzes1
- Dicamba monooxygenase: structural insights into a dynamic Rieske oxygenase that catalyzes an exocyclic monooxygenation. (semanticscholar.org)
Fungal1
- Due to its high therapeutic index, azoles are first-line drugs for the treatment of invasive fungal infections [ 4 , 5 ]. (hindawi.com)
Aspergillus1
- The first gene identified in this family is the CYP53A1 from Aspergillus niger encoding the Benzoate 4-monooxygenase (bphA). (wikipedia.org)
Preferentially1
- Mutations in (assays, PBS3 conjugates amino acids preferentially to 4-substituted benzoates and is usually inhibited by SA (20). (biobender.com)
19891
- 1989 Aug 20;208(4):679-96. (nih.gov)