Benzo(a)pyrene
Benzopyrenes
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
Dihydroxydihydrobenzopyrenes
DNA Adducts
Polycyclic Hydrocarbons, Aromatic
A major group of unsaturated cyclic hydrocarbons containing two or more rings. The vast number of compounds of this important group, derived chiefly from petroleum and coal tar, are rather highly reactive and chemically versatile. The name is due to the strong and not unpleasant odor characteristic of most substances of this nature. (From Hawley's Condensed Chemical Dictionary, 12th ed, p96)
Carcinogens
Mutagens
Biotransformation
The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
Benzopyrene Hydroxylase
Epoxy Compounds
Benz(a)Anthracenes
Cytochrome P-450 CYP1A1
A liver microsomal cytochrome P-450 monooxygenase capable of biotransforming xenobiotics such as polycyclic hydrocarbons and halogenated aromatic hydrocarbons into carcinogenic or mutagenic compounds. They have been found in mammals and fish. This enzyme, encoded by CYP1A1 gene, can be measured by using ethoxyresorufin as a substrate for the ethoxyresorufin O-deethylase activity.
Mutagenicity Tests
Coal Tar
A by-product of the destructive distillation of coal used as a topical antieczematic. It is an antipruritic and keratoplastic agent used also in the treatment of psoriasis and other skin conditions. Occupational exposure to soots, tars, and certain mineral oils is known to be carcinogenic according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985) (Merck Index, 11th ed).
Aryl Hydrocarbon Hydroxylases
A large group of cytochrome P-450 (heme-thiolate) monooxygenases that complex with NAD(P)H-FLAVIN OXIDOREDUCTASE in numerous mixed-function oxidations of aromatic compounds. They catalyze hydroxylation of a broad spectrum of substrates and are important in the metabolism of steroids, drugs, and toxins such as PHENOBARBITAL, carcinogens, and insecticides.
Benzoflavones
Organic compounds containing a BENZENE ring attached to a flavone group. Some of these are potent arylhydrocarbon hydroxylase inhibitors. They may also inhibit the binding of NUCLEIC ACIDS to BENZOPYRENES and related compounds. The designation includes all isomers; the 7,8-isomer is most frequently encountered.
Glycols
Cytochrome P-450 Enzyme System
A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.
Stereoisomerism
DNA
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Receptors, Aryl Hydrocarbon
Cytoplasmic proteins that bind certain aryl hydrocarbons, translocate to the nucleus, and activate transcription of particular DNA segments. AH receptors are identified by their high-affinity binding to several carcinogenic or teratogenic environmental chemicals including polycyclic aromatic hydrocarbons found in cigarette smoke and smog, heterocyclic amines found in cooked foods, and halogenated hydrocarbons including dioxins and polychlorinated biphenyls. No endogenous ligand has been identified, but an unknown natural messenger with a role in cell differentiation and development is suspected.
Anisoles
Creosote
A greasy substance with a smoky odor and burned taste created by high temperature treatment of BEECH and other WOOD; COAL TAR; or resin of the CREOSOTE BUSH. It contains CRESOLS and POLYCYCLIC AROMATIC HYDROCARBONS which are CARCINOGENS. It has been widely used as wood preservative and in PESTICIDES and had former use medicinally in DISINFECTANTS; LAXATIVES; and DERMATOLOGIC AGENTS.
Enzyme Induction
Metabolic Detoxication, Drug
Trichloroepoxypropane
beta-Naphthoflavone
Papilloma
Neoplasms, Experimental
Biodegradation, Environmental
Tetrachlorodibenzodioxin
Environmental Pollutants
9,10-Dimethyl-1,2-benzanthracene
Fundulidae
2-Acetylaminofluorene
DNA Damage
Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.
Butylated Hydroxyanisole
Liver
Microsomes, Liver
Benzo(e)pyrene
Benzopyrene Benzo[a]pyrene Benzene Pyrene, a four-ring analogue v t e (Articles with short description, Short description ... Benzo[e]pyrene is a polycyclic aromatic hydrocarbon with the chemical formula C20H12. It is listed as a Group 3 carcinogen by ...
Benzo(a)pyrene
Benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide is the carcinogenic product of three enzymatic reactions: Benzo[a]pyrene is first ... Benzopyrene Benzo[e]pyrene Pyrene, a four-ring analogue Toxification Henri A. Favre, Warren H. Powell (2013). Nomenclature of ... ISBN 978-1-4987-5429-3. "benzo[a]pyrene". pubchem.ncbi.nlm.nih.gov. "Assessment of Benzo-alpha-pyrene Emissions in the Great ... pyrene-7,8-epoxide. This product is metabolized by epoxide hydrolase, opening up the epoxide ring to yield (−)benzo[a]pyrene-7, ...
Benzopyrene
Two isomeric species of benzopyrene are benzo[a]pyrene and the less common benzo[e]pyrene. They belong to the chemical class of ... Benzo[a]pyrene Benzo[e]pyrene W. D. Betts "Tar and Pitch" in Kirk‑Othmer Encyclopedia of Chemical Technology, 1997, John Wiley ... benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide from benzo[a]pyrene) which intercalate into DNA, interfering with transcription. ... Denissenko, M. F.; Pao, A.; Tang, M.-s.; Pfeifer, G. P. (1996). "Preferential Formation of Benzo[a]pyrene Adducts at Lung ...
Benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide
Benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide is a metabolite of benzo[a]pyrene formed by the introduction of vicinal hydroxyl ... Benzo[a]pyrene is a derivative in which a fifth benzene ring has been fused to the pyrene system, and is a component of tobacco ... pyrene, but the syn isomers are also produced. (+)-Benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide has been shown to bind to an N2 ... pyrene-7,8-epoxide. The enzyme epoxide hydrolase, then hydrates the epoxide ring to yield the vicinal diol (−)-benzo[a]pyrene-7 ...
Olympicene
Mistry, A. (31 May 2012). "Dehydration of 3,4-dihydro-5H-Benzo[cd]pyren-5-ol; 6H-Benzo[cd]pyrene". ChemSpider. Royal Society of ... Benzo[cd]pyrenes". Chemistry: A European Journal. 21 (5): 2011-2018. doi:10.1002/chem.201404877. PMID 25469908. Palmer, J. (28 ... On reduction of this ketone using lithium aluminium hydride the alcohol 3,4-dihydro-5H-benzo[cd]pyren-5-ol was obtained, the 3, ... A very similar molecule (benzo[c]phenanthrene) which lacks the -CH2- spacer between the two sides of the molecule has been ...
Health effects of tobacco
The first PAH to be identified as a carcinogen in tobacco smoke was benzopyrene, which has been shown to toxicate into an ... pyrene in a fully complementary DNA duplex: evidence for a major syn conformation". Biochemistry. 40 (20): 5870-81. doi:10.1021 ... The first PAH to be identified as a carcinogen in tobacco smoke was benzopyrene, which been shown to toxicate into a diol ... "DNA interaction with Benzopyrene". DNA. Archived from the original on December 23, 2004. Retrieved March 5, 2005. Kataoka H, ...
Chimney sweeps' carcinoma
Benzo(α)pyrene interacts with deoxyguanosine of the DNA, damaging it and potentially starting the processes that can lead to ... benzo[α]pyrene. DNA consists of sequences of four bases - guanine, adenine, cytosine, and thymine - bound to a deoxyribonucleic ...
Sphingomonas yanoikuyae
Rentz JA, Alvarez PJ, Schnoor JL (February 2008). "Benzo[a]pyrene degradation by Sphingomonas yanoikuyae JAR02". Environmental ...
Human papillomavirus infection
Alam S, Conway MJ, Chen HS, Meyers C (January 2008). "The cigarette smoke carcinogen benzo[a]pyrene enhances human ...
Novosphingobium pentaromativorans
Luo, Y. R.; Kang, S. G.; Kim, S.-J.; Kim, M.-R.; Li, N.; Lee, J.-H.; Kwon, K. K. (2012). "Genome Sequence of Benzo(a)pyrene- ...
Cellulosimicrobium cellulans
One significant compound the bacteria can biodegrade is benzo(a)pyrene (BaP). BaP is a polycyclic aromatic hydrocarbon (PAH), ... "Anaerobic biodegradation of benzo(a)pyrene by a novel Cellulosimicrobium cellulans CWS2 isolated from polycyclic aromatic ...
Pigment Violet 29
Perylene is less toxic than its well-studied cousin benzo[a]pyrene. Little is actually known about the mechanistic toxicology ...
Izrael Hieger
This was identified as 3:4-benzo(a)pyrene, and highly carcinogenic. The discovery confirmed concerns over the correlation ...
Mycobacterium pyrenivorans
Mineralizes phenanthrene, fluoranthene, and pyrene, but not anthracene or benzo[a]pyrene. Differential characteristics The ... Etymology: pyrenivorans; digesting pyrene. Microscopy Gram-positive, acid-fast rods. Colony characteristics The rough colonies ...
Smoke
... benzo[a]pyrene, studied as a carcinogen, or retene), terpenes. It also results in the emission of a range of smaller oxygenated ...
GNMT
Lee CM, Chen SY, Lee YC, Huang CY, Chen YM (July 2006). "Benzo[a]pyrene and glycine N-methyltransferse interactions: gene ... "Glycine N-methyltransferase tumor susceptibility gene in the benzo(a)pyrene-detoxification pathway". Cancer Research. 64 (10): ...
Arene oxide
Benzopyrene is also converted to an epoxide, (+)-benzo[a]pyrene-7,8-epoxide. Benzene oxide (C6H6O) exists as an equilibrium ...
Eliezer (Eli) Huberman
"Cell specificity in metabolic activation of aflatoxin B1 and benzo(a)pyrene to mutagens for mammalian cells". Nature. 276 (5685 ... "Cell susceptibility to transformation and cytotoxicity by the carcinogenic hydrocarbon benzo[a]pyrene". PNAS. 56 (5): 1123-1129 ...
UGT1A3
Substrates of this enzyme include estrone, 2-hydroxyestrone, and metabolites of benzo(a)pyrene. GRCh38: Ensembl release 89: ...
Chrysene
... is estimated to have about 1% of the toxicity of benzo(a)pyrene. Derivatives of chrysene include tetrahydrochrysene ...
Methylcholanthrene
Deoxyguanosine is used in the figure, since that base appears to be bound to Benzo[a]pyrene far more often than the other bases ... The mechanism is derived from the binding mechanism of benzo[a]pyrene to DNA. This is likely because it is plausible that two ... "Comparison of the in vitro mutagenicity and metabolism of dimethylnitrosamine and benzo[a]pyrene in tissues from inbred mice ...
Benzo(j)fluoranthene
Benzo[a]pyrene now has been well characterized in toxicology reports and is a known potent carcinogen. Benzo[a]pyrene requires ... "Tumour initiating activity of dihydrodiols of benzo[b]fluoranthene, benzo[j]fluoranthene, and benzo[k]fluoranthene." ... Benzo[a]pyrene has been extensively reviewed and is used as a model for the toxicology and metabolism of other PAHs. Specific ... "Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53." Science 274.5286 (1996): 430-432. ...
Mir-638 microRNA precursor family
"Aberrant expression of miR-638 contributes to benzo(a)pyrene-induced human cell transformation". Toxicological Sciences. 125 (2 ...
Curtis C. Harris
"Interindividual variation in binding of benzo[a]pyrene to DNA in cultured human bronchi". Science. 194 (4269): 1067-1069. doi: ...
Dolores Cooper Shockley
Furthermore, her research showed that the effects of benzo(a)pyrene, which is present in tobacco smoke and grilled meats, are ... Shockley studied how pollutants such as benzo(a)pyrene and fluoranthene affect the nervous system. Her research showed that ... Saunders, Crystal R.; Das, Salil K.; Ramesh, Aramandla; Shockley, Dolores C.; Mukherjee, Shyamali (2006). "Benzo(a)pyrene- ... "Modulation of neurotoxic behavior in F-344 rats by temporal disposition of benzo(a)pyrene". Toxicology Letters. 129 (1): 33-45 ...
Dissolvable tobacco
... benzo[a]pyrene), and metals" have not been assessed. However, Star Scientific notes, "there is currently no proof that lowering ...
UGT1A10
Zheng Z, Fang JL, Lazarus P (2002). "Glucuronidation: an important mechanism for detoxification of benzo[a]pyrene metabolites ...
2,3,7,8-Tetrachlorodibenzodioxin
An example is benzo(a)pyrene that is metabolized in two steps, oxidation and conjugation. Oxidation produces epoxide ... carcinogenic polycyclic hydrocarbons such as benzo(a)pyrene. These polycyclic hydrocarbons also activate the AH receptor, but ...
Benzo(c)fluorene
... pyrene (RPF). Although the concentrations measured of benzo[c]fluorene are quite low, when corrected for mutagenicity, benzo[c] ... Other names for benzo[c]fluorene are 7H-benzo[c]fluorene, 3,4-benzofluorene, and NSC 89264. The structure of benzo[c]fluorene ... Benzo[a]fluorene Koganti A, Singh R, Rozett K, Modi N, Goldstein LS, Roy TA, Zhang FJ, Harvey RG, Weyand EH (2000). "7H-benzo[c ... The researchers corrected for the relative mutagenicity of compounds compared to benzo[a]pyrene. The results of this are ...
Ohio River Park
... anthracene and benzo(a)pyrene. The cleanup goal of benzo(a)anthracene and benzo(a)pyrene was set at a soil concentration of ... The cleanup goal of benzo(a)anthracene and benzo(a)pyrene was achieved. OU2 dealt with building a new Coraopolis Bridge on top ... benzo(a)pyrene, benzo(a)anthracene, dibenz(a,h)antharacene, 4-methylphenol, 2,4-dichlorophenol, 2,4,6-trichlorophenol, dieldrin ... The soil contaminants of concern in 1996 were benzo(a) ...
Mir-542 microRNA precursor family
Zhao Y, Liu HY, Li YQ, Jiang YG (May 2011). "[Effect of miR-542-3p on carcinogenesis induced by anti-benzo(a) pyrene-7,8-diol-9 ...
JWH-015
... see for example benzo(a)pyrene toxicity) can produce carcinogenic metabolites, although there is no evidence to show that JWH- ...
AP-1 transcription factor
"Genistein protects human mammary epithelial cells from benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide and 4-hydroxy-2-nonenal ...
Mir-22
... "miR-22 functions as a micro-oncogene in transformed human bronchial epithelial cells induced by anti-benzo[a]pyrene-7,8-diol-9, ...
Toxication
Benzo[a]pyrene into the carcinogenic benzo[a]pyrene diol epoxide (BP-7,8-dihydrodiol-9,10-epoxide) Hypoglycin A into the highly ...
Crumb rubber
Chemicals such as chrysene, benzo(a)pyrene, benzo(e)pyrene, benzene and others are now on the restricted chemicals Candidate ...
DNA repair
"bulky adduct formation" (e.g., benzo[a]pyrene diol epoxide-dG adduct, aristolactam I-dA adduct) mismatch of bases, due to ...
I. Bernard Weinstein
Weinstein investigated the cancer risks caused by benzo[a]pyrene, which is found in automobile exhaust, barbecued food and ...
Mir-363 microRNA precursor family
"MicroRNA expression profiles and miR-10a target in anti-benzo[a] pyrene-7, 8-diol-9, 10-epoxide-transformed human 16HBE cells ...
Somatic mutation
... such as metabolites of benzo[a]pyrene, a potent carcinogen found in tobacco smoke. Mutagens associated with cancers are often ...
Cunninghamella elegans
Cerniglia, C. E.; Mahaffey, W.; Gibson, D. T. (1980). "Fungal oxidation of benzo\a]pyrene: Formation of (−)-trans-7,8-dihydroxy ... fluorene or benzo(a)pyrene. In the case of phenanthrene, C. elegans produces a glucoside conjugate of 1-hydroxyphenanthrene ( ... 8-dihydrobenzo\a]pyrene by Cunninghamella elegans". Biochemical and Biophysical Research Communications. 94 (1): 226-232. doi: ...
Air pollution
Benzo(a)pyrene (BaP) is a well-known PAH and carcinogen which is often found in exhaust fumes and cigarette smoke. PAHs have ...
Dillo Dirt
... benzo(b)fluoranthene, dibenz(a,h)anthracene, benzo(a)anthracene, indeno(1,2,3-cd)pyrene, and bis(2-ethylhexyl)phthalate. Very ...
Smelting
For example, aluminum smelters typically generate fluoride, benzo(a)pyrene, antimony and nickel, as well as aluminum. Copper ...
Energy poverty and cooking
... such as benzo-a-pyrene, which are thought to have both short and long term health consequences. Exposure to household air ...
Smoking
Although several carcinogens were already known at the time (for example, benzo[a]pyrene was isolated from coal tar and ...
Chlorophyllin
In vitro, it binds to some environmental mutagens such as the polycyclic aromatic hydrocarbons benzo[a]pyrene and dibenzo[a,i] ... "Chlorophyllin significantly reduces benzo[a]pyrene-DNA adduct formation and alters cytochrome P450 1A1 and 1B1 expression and ... pyrene. Chlorophyllin also binds to acridine orange. Chlorophyllin has been validated to exhibit ameliorative effects against ...
Mir-506 microRNA precursor family
"The role of miR-506 in transformed 16HBE cells induced by anti-benzo[a]pyrene-trans-7,8-dihydrodiol-9,10-epoxide". Toxicology ...
Blackout tattoo
The dark pigments typically used to create blackout tattoos often contain carcinogens such as benzo(a)pyrene, and toxic ...
N-Heterocyclic carbene boryl anion
PAHs that have a pyrene core all fluoresce blue light under UV light, but their smaller and more planar counterparts had a ... "Syntheses and structures of benzo-bis(1,3,2-diazaboroles) and acenaphtho-1,3,2-diazaboroles". Royal Society of Chemistry. 2019 ... This change in color is attributed to the NHC boryl anion rings contributing more to the smaller PAHs, whereas in the pyrene ... Modulating Structure and Photophysics in Pyrene- and Benzene-Fused N-Heterocyclic Boranes". Chemistry - A European Journal. 26 ...
RAD23B
... adducts formed by environmental mutagens such as benzo[a]pyrene or various aromatic amines, certain oxidative endogenous ...
Soil contamination
... benzo(a)anthracene, benzo(b)fluoranthene, benzo(k)fluoranthene, benzo(a)pyrene, indeno(cd)pyrene, phenanthrene, anthracene, and ... Toxicological data (Tox) has been published for each of these contaminants as well as for benzo[a]pyrene, benzene, dioxins, ... such as naphthalene and benzo(a)pyrene), solvents, pesticides, lead, and other heavy metals. Contamination is correlated with ...
Toast (food)
Toasted bread may contain Benzo[a]pyrene and high levels of acrylamide, a carcinogen generated during the browning process. ...
Toll-like receptor 2
... which is a key enzyme in detoxication of carcinogenic polycyclic aromatic hydrocarbons such as benzo(a)pyrene. The immune ... Uno S, Dalton TP, Dragin N, Curran CP, Derkenne S, Miller ML, Shertzer HG, Gonzalez FJ, Nebert DW (April 2006). "Oral benzo[a] ... pyrene in Cyp1 knockout mouse lines: CYP1A1 important in detoxication, CYP1B1 metabolism required for immune damage independent ...
![EWG Tap Water Database | Marianna | Benzo[a]pyrene](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABAAAAAQCAYAAAAf8/9hAAAB/0lEQVQ4jV3TMWiVZxQG4OfcXi4iJS3ODiLBQhCHItUhSLhkCBJvUsiUhiA0/JbiVhAMiOgQxM1BkYtIFAmlU+9tKKGUeEHJIkjRICgOTsWhZKmDBPE4/J/E+MHhh+87/3vOed/zhs9Pt3MYFcaxUW6PYx1dVX/z0/TY+XFqD3kVP2ENvxOD+jHHMI0J3CDOqXrbOwDdqRbZx0FilmxhHkcK/BPcJd6RK3ghY9qZ3najVFjCMNEmKwwwhJUSQ/UIuYAxHBK5VHfQnRomnxFj5BxOEpPk1+iggVXiP3IVfxL3yAEx0iioA2xjgeiQM3hQqo3iPjlbv1kouevkQgPtmrCcQ7/MfxE/qPrfqfrH8T3Ok3tLznz91W7iAPGS3Fc6OYmnxJpuZxmtQuT/RYW7OCK9EA408Z58j3/xxu7TKKGe3Qbe4fXHBWjiFQ6VmCSWyEvkhKo/X2Q+gS1Vb1O38xtel85ehW7nCr4lFskNHMUMLuBR3aFj+AV/4TExSl7GP03iVi2jFm7V5MRknZxFxlisq+YqbktNoS2d/cIfz7ec+uarmuX4EftxHV9iE1tlH66hR1wW2cMdZ/q/NmsqYpEcKcsxi2XyNOYKgU+Icbwl1/GydLXLTK1ipp99NFMaiFDM1CkS3yxmersbYAfocPFDGw+LjKP4m+iqervs/AF2Wq4LIo7jUgAAAABJRU5ErkJggg==)
EWG Tap Water Database | Marianna | Benzo[a]pyrene
... pyrene results for Marianna , Benzo[a]pyrene. Find out what is in your tap water ... Benzo[a]pyrene. Marianna. Benzo[a]pyrene is a polycyclic aromatic hydrocarbon, or PAH, released from combustion of fossil fuels ... The EWG Health Guideline of 0.007 ppb for benzo[a]pyrene was defined by the California Office of Environmental Health Hazard ... The legal limit for benzo[a]pyrene, established in 1992, was based on analytical detection limits at the time that the standard ...
Browsing Publications by Subject "Benzo(‎a)‎pyrene"
Nomination Summary for Benzo(a)pyrene (N89201)
![Early-Life Exposure to Benzo[a]pyrene Increases Mutant Frequency in Spermatogenic Cells in Adulthood | PLOS ONE](data:image/png;base64,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)
Early-Life Exposure to Benzo[a]pyrene Increases Mutant Frequency in Spermatogenic Cells in Adulthood | PLOS ONE
... benzo[a]pyrene, B[a]P) at different doses (0, 50, 200 or 300 mg/kg body weight). Mutant frequency was then determined in a ... Leavitt SA, George MH, Moore T, Ross JA (2008) Mutations induced by benzo[a]pyrene and dibenzo[a,l]pyrene in lacI transgenic ... Benzo[a]pyrene (B[a]P) Treatment. B[a]P (Fluka Chemical Corp., Milwaukee WI) was ground into a fine powder using a mortar and ... 2011) Evaluation of benzo(a)pyrene-induced gene mutations in male germ cells. Toxicol Sci 119: 218-223. * View Article ...
Benzo(a)pyrene - Annual target value for the protection of human health
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European Environment Agency
data-and-maps/figures/ga-downloads/Z2DO9TP9NZ/benzo-a-pyrene-annual Download. * Original file application/postscript (10.05 MB ... Benzo(a)pyrene - Annual target value for the protection of human health This website has limited functionality with javascript ... This page was archived on 22 Aug 2014 with reason: Other (New version data-and-maps/figures/benzo-a-pyrene-annual-3 was ... www.eea.europa.eu/data-and-maps/figures/benzo-a-pyrene-annual or scan the QR code. ...
![ACP - Can biomonitors effectively detect airborne benzo[a]pyrene? An evaluation approach using modelling](data:image/png;base64,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)
ACP - Can biomonitors effectively detect airborne benzo[a]pyrene? An evaluation approach using modelling
Can biomonitors effectively detect airborne benzo[a]pyrene? An evaluation approach using modelling Nuno Ratola1,2 and Pedro ... Ratola, N. and Jiménez-Guerrero, P.: Can biomonitors effectively detect airborne benzo[a]pyrene? An evaluation approach using ... benzo[a]pyrene (BaP). A comparison of ways to estimate air concentrations of BaP from its levels in vegetation is also a strong ... in pine needles from the Iberian Peninsula were used to estimate air concentrations of benzo[a]pyrene (BaP) and, at the same ...
The Effect of Benzo(a)pyrene on the Basal and Isoproterenolstimulated Levels of Cyclic Adenosine 3′,5′-Monophosphate in Mouse...
Application of benzo(a)pyrene to the dorsal skin did not increase the basal cyclic AMP levels in the ears; this indicates that ... Topical application of benzo(a)pyrene caused a rise in the basal levels of cyclic AMP and a decreased response to isoproterenol ... The effect of benzo(a)pyrene on the accumulation of cyclic adenosine 3′,5′-monophosphate (cyclic AMP) in mouse skin in response ... The Effect of Benzo(a)pyrene on the Basal and Isoproterenolstimulated Levels of Cyclic Adenosine 3′,5′-Monophosphate in Mouse ...
Benzopyrenes | Profiles RNS
Below are MeSH descriptors whose meaning is related to "Benzopyrenes".. *Pyrenes. *Benzopyrenes ... "Benzopyrenes" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Benzopyrenes" by people in UAMS Profiles by year, and whether ... Below are the most recent publications written about "Benzopyrenes" by people in Profiles over the past ten years. ...
Reducing Concentrations of Benzo(a)pyrene
in Gas Phase Soot Particles by Using
and Burning Water Fuel Emulsions
... pyrene degraded into more harmful substances. Consequently, the thermodynamic parameters of the benzo(a)... ... pyrene-water-oxygen systems were investigated in wide ranges of change of temperature value and initial components to predict ... pyrene in the gas phase was the water content in fuel oil within 10-15%.. Determination of the concentration of benzo(a)pyrene ... pyrene degraded into more harmful substances. Consequently, the thermodynamic parameters of the benzo(a) pyrene-water-oxygen ...
![Differences in the covalent binding of benzo[a]pyrene, safrole, 1′-hydroxysafrole, and 4-aminobiphenyl to DNA of pregnant and...](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABAAAAAMCAMAAABcOc2zAAAAWlBMVEXwOkfyOkbyOUXxOkf70NPwQU3zSVT+///98fLwMT/wKjvzW2X2lp3wJTrxOUn5ub3wIzT1cHj83d/wBiP81Nj99vb4q6/95ufyc331g4v97O7zZW/60NLxNkgVmvkXAAAAbklEQVQImX3I0Q6CMAyF4dN2o2PIKJOJoHv/15QleqEk/k2Tkw/0E07wnfwBAbj/gMQGNFz6AyTymCazMdqcr5Hgp84t6lq5uFuEX324h20/XpctG3wpIYXH2u2Dqj4NkmqCCDhVqSIMYmZ6X5svI0IEcIdcVM0AAAAASUVORK5CYII=)
Differences in the covalent binding of benzo[a]pyrene, safrole, 1′-hydroxysafrole, and 4-aminobiphenyl to DNA of pregnant and...
Non-pregnant or timed-pregnant (18th day of gestation) ICR mice of similar age were treated with benzo[a]pyrene (BP, 200 μmol/ ... Lu, L. J. W., Disher, R. M., & Randerath, K. (1986). Differences in the covalent binding of benzo[a]pyrene, safrole, 1′- ... Non-pregnant or timed-pregnant (18th day of gestation) ICR mice of similar age were treated with benzo[a]pyrene (BP, 200 μmol/ ... Non-pregnant or timed-pregnant (18th day of gestation) ICR mice of similar age were treated with benzo[a]pyrene (BP, 200 μmol/ ...
Suppressive effects of methyl methacrylate on the mutagenicity and DNA adduct formation induced by 1-nitropyrene and benzo[a...
In the present study, the effects of MMA on the mutagenicity of 1-nitropyrene (1-NP) and benzo[a]pyrene (B[a]P) were evaluated ... In the present study, the effects of MMA on the mutagenicity of 1-nitropyrene (1-NP) and benzo[a]pyrene (B[a]P) were evaluated ... In the present study, the effects of MMA on the mutagenicity of 1-nitropyrene (1-NP) and benzo[a]pyrene (B[a]P) were evaluated ... In the present study, the effects of MMA on the mutagenicity of 1-nitropyrene (1-NP) and benzo[a]pyrene (B[a]P) were evaluated ...
![Modulation of benzo[a]pyrene diolepoxide-DNA adduct levels in human white blood cells by CYP1A1, GSTM1 and GSTT1 polymorphism ...](data:image/png;base64,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)
Modulation of benzo[a]pyrene diolepoxide-DNA adduct levels in human white blood cells by CYP1A1, GSTM1 and GSTT1 polymorphism ...
... pyrene diolepoxide (BPDE)DNA adduct levels by polymorphisms in the CYP1A1, GSTM1 and GSTT1 genes was assessed in leukocytes of ... NUMBER OF PACKS OF CIGARETTES SMOKED PER DAY MULTIPLIED BY THE NUMBER OF YEARS OF SMOKING B[A]P BENZO[A]PYRENE BPDE (+-)-TRANS- ... The modulation of benzo[a]pyrene diolepoxide (BPDE)DNA adduct levels by polymorphisms in the CYP1A1, GSTM1 and GSTT1 genes was ... Modulation of benzo[a]pyrene diolepoxide-DNA adduct levels in human white blood cells by CYP1A1, GSTM1 and GSTT1 polymorphism. ...
Benzo a pyrene: stations above LOD/LOQ
Summit Environmental Testing | BENZO(A)PYRENE EQUIVALENTS
IMSEAR at SEARO: Method Development of Benzo(a)Pyrene in Charcoal-Grilled Animal Tissue
Method Development of Benzo(a)Pyrene in Charcoal-Grilled Animal Tissue. Authors: Jitpaka Suntudrob. Thongsuk Payanun. Kanokporn ... Benzo(a)pyrene (BaP) is one of the compound of polycyclic aromatic hydrocarbons incharcoal-grilled animal tissue as a result of ... Determination of benzo(a)pyrene was studied and developed. The sample wassaponififfiified with base and separated by solid ... Benzo(a)pyrene, Food, Method validation, Polycyclic aromatic hydrocarbons. ...
Alphabetical Method Listing - B - NMAM 4th Edition | NIOSH | CDC
Benzo(a)pyrene. 5515. POLYNUCLEAR AROMATIC HYDROCARBONS. Benzo[a]fluoranthene. 5506. POLYNUCLEAR AROMATIC HYDROCARBONS by HPLC ... Benzo(b)fluoranthene. 5515. POLYNUCLEAR AROMATIC HYDROCARBONS. Benzo[e]pyrene. 5506. POLYNUCLEAR AROMATIC HYDROCARBONS by HPLC ... Benzo(e)pyrene. 5515. POLYNUCLEAR AROMATIC HYDROCARBONS. Benzo[k]fluoranthene. 5506. POLYNUCLEAR AROMATIC HYDROCARBONS by HPLC ... Benzo(k)fluoranthene. 5515. POLYNUCLEAR AROMATIC HYDROCARBONS. Benzo[ghi]perylene. 5506. POLYNUCLEAR AROMATIC HYDROCARBONS by ...
ISKOPolycyclic Aromatic Hydrocarbons (PAHs) | Public Health Statement | ATSDR
Several of the PAHs, including benz[a]anthracene, benzo[a]pyrene, benzo[b]fluoranthene, benzo[j]fluoranthene, benzo[k] ... benzo[j]fluoranthene, benzo[k]fluoranthene, benzo[a]pyrene, dibenz[a,h]anthracene, and indeno[1,2,3-c,d]pyrene are known animal ... EPA has determined that benz[a]anthracene, benzo[a]pyrene, benzo[b]fluoranthene, benzo[k]fluoranthene, chrysene, dibenz[a,h] ... benzo[b]fluoranthene, benzo[j]fluoranthene, benzo[k]fluoranthene, and indeno[1,2,3-c,d]pyrene are possibly carcinogenic to ...
Tle6 (TLE family member 6, subcortical maternal complex member) - Rat Genome Database
benzo[a]pyrene affects methylation. ISO. RGD:1343822. 6480464. Benzo(a)pyrene affects the methylation of TLE6 3 UTR. CTD. PMID ... benzo[a]pyrene increases expression. ISO. RGD:1557715. 6480464. Benzo(a)pyrene results in increased expression of TLE6 mRNA. ... benzo[a]pyrene decreases expression. ISO. RGD:1557715. 6480464. Benzo(a)pyrene results in decreased expression of TLE6 mRNA. ... benzo[a]pyrene increases methylation. ISO. RGD:1343822. 6480464. Benzo(a)pyrene results in increased methylation of TLE6 5 UTR ...
Benzoapyrene | GreenMedInfo | Toxic Ingredient | Natural Medicine
Additional Keywords : Beet, Benzo(a)pyrene, Betaine, lung cancer, Vinyl Carbamate. Problem Substances : Benzo(a)pyrene, Vinyl ... Diseases : Benzo[a]pyrene-induced Toxicity , Lung Cancer. Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, ... Diseases : Benzo[a]pyrene-induced Toxicity , Lung Cancer, Lung Damage. Pharmacological Actions : Anti-Inflammatory Agents, ... Diseases : Benzo[a]pyrene-induced Toxicity , Lung Cancer. Pharmacological Actions : Antiproliferative , Apoptotic, Cyclin D1 ...
ATSDR - PHA - Evaluation of Current (1990 to 2003) and Future Chemical Exposures in the Vicinity of the Oak Ridge Reservation,...
![Risk Control Values and Remediation Goals for Benzo[|i|a|/i|]pyrene in Contaminated Sites: Sectoral Characteristics, Temporal...](data:image/png;base64,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)
Risk Control Values and Remediation Goals for Benzo[|i|a|/i|]pyrene in Contaminated Sites: Sectoral Characteristics, Temporal...
Benzo[a]pyrene (BaP) is a highly carcinogenic pollutant of global concern. There is a need for a comprehensive assessment of ... benzo[a]pyrene; contaminated sites; cumulative frequency; remediation goals; risk control values; temporal variations ... Risk Control Values and Remediation Goals for Benzo[a]pyrene in Contaminated Sites: Sectoral Characteristics, Temporal Trends, ... Risk Control Values and Remediation Goals for Benzo[,i,a,/i,]pyrene in Contaminated Sites: ...
Destroying the Balance of Nature - Los Angeles Times
"Microcosm Study of the Accumulation of Benzo(a)pyrene by Lake Whatcom " by Shannon Ashurst
... pyrene (BaP) accumulation by phytoplankton using laboratory studies and natural assemblages of Lake Whatcom (Bellingham, WA) ... I developed a preliminary method for measuring in situ benzo(a) ... Lake Whatcom phytoplankton, Benzo(a)pyrene accumulation, in ... I developed a preliminary method for measuring in situ benzo(a)pyrene (BaP) accumulation by phytoplankton using laboratory ... Ashurst, Shannon, "Microcosm Study of the Accumulation of Benzo(a)pyrene by Lake Whatcom Phytoplankton" (2003). Lake Whatcom ...
Carcinogen News, Research - Page 5
Cellular binding of benzo(a)pyrene to DNA characterized by low temperature fluorescence - Fingerprint - NYU Scholars
Reporting Harmful and Potentially Harmful Constituents in Tobacco Products and Tobacco Smoke Under Section 904(a)(3) of the...
EUR-Lex - 32016D1371 - EN - EUR-Lex
Polbase - Reference: Characterization of human DNA polymerase κ promoter in response to benzo[a]pyrene diol epoxide.
Characterization of human DNA polymerase κ promoter in response to benzo[a]pyrene diol epoxide. ... Characterization of human DNA polymerase κ promoter in response to benzo[a]pyrene diol epoxide. Zhu H, Fan Y, Shen J, Qi H, ... 8-oxo-G and aromatic adducts such as benzo[a]pyrene diol epoxide (BPDE). However, few studies have been done on the ...
ProteÃna del suero: MedlinePlus suplementosAnthracene2
- Roberto A, Larsson BS, Tjälve H. Uptake of 7,12-dimethylbenz(a)anthracene and benzo(a)pyrene in melanin-containing tissues. (medscape.com)
- The investigators examined study participants' urine for three other carcinogens - benz(a)anthracene, benzo(a)pyrene, and 1- hydroxypyrene - but found no significant findings for these molecules. (medscape.com)
Benzene2
- But it is the pollution they cannot see - known cancer-causing contaminants like benzo(a)pyrene and benzene, for example - that worry them most. (thespec.com)
- In both cities, new or expanding industries now face extra pollution control requirements related to benzene and benzo(a)pyrene emissions. (thespec.com)
Carcinogenic5
- This original interpretation and application of environmental databases combines biomonitoring and atmospheric field data and state-of-the-art chemistry transport models to study one of the most carcinogenic atmospheric pollutants, benzo[ a ]pyrene (BaP). (copernicus.org)
- Pregnancy lowered the binding of the ultimate carcinogenic metabolite of BP, 7β,8α-dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE I), to liver and lung DNA by 29-41%, but not the binding of other metabolites. (utmb.edu)
- Benzo[a]pyrene (BaP) is a highly carcinogenic pollutant of global concern. (bvsalud.org)
- Maria Munoz, a colleague of Heeb's from Empa's Advanced Analytical Technologies lab, took a closer look at the exhaust emissions from the vehicles tested in the GasOMeP project - and discovered the combustion product benzo(a)pyrene, a known carcinogenic substance also found in cigarette smoke. (empa.ch)
- Benzo[a]pyrene is highly carcinogenic and is most often encountered in tobacco smoke. (courthousenews.com)
Adducts3
- DNA polymerase κ (Pol κ), a member of Y-family DNA polymerases, can synthesize DNA with moderate fidelity on undamaged DNAs and replicate accurately in vitro thymine glycol, 8-oxo-G and aromatic adducts such as benzo[a]pyrene diol epoxide (BPDE). (neb.com)
- Genetic polymorphisms in biotransformation enzymes for benzo[a]pyrene and related levels of benzo[a]pyrene-7,8-diol-9,10-epoxide-DNA adducts in Goeckerman therapy. (cdc.gov)
- Food borne bacterial models for detection of benzo[a]pyrene-DNA adducts formation using RAPD-PCR. (cdc.gov)
Hydrocarbons4
- Biomonitoring data available on levels of atmospheric polycyclic aromatic hydrocarbons (PAHs) in pine needles from the Iberian Peninsula were used to estimate air concentrations of benzo[ a ]pyrene (BaP) and, at the same time, fuelled the comparison with chemistry transport model representations. (copernicus.org)
- Benzo(a)pyrene (BaP) is one of the compound of polycyclic aromatic hydrocarbons incharcoal-grilled animal tissue as a result of incomplete combustion or pyrolysis of organic matter which areprobable human carcinogen. (who.int)
- Once burned, the two substances share carcinogens, including toxic gases, reactive oxygen species, and polycyclic aromatic hydrocarbons like benzo[α]pyrene and phenols. (medscape.com)
- The aerosol PAH (polycyclic aromatic hydrocarbons) profile showed higher proportions of the heavier PAHs, such as benzo[a]pyrene, compared to diesel truck exhaust on a per unit mass. (elsevier.com)
Substances3
- In this study, benzo(a)pyrene-water-oxygen systems were investigated in wide ranges of change of temperature value and initial components to predict in which conditions benzo(a)pyrene degraded into more harmful substances. (pjoes.com)
- Melanin can bind to many different compounds, including nicotine and benzopyrene present in the tobacco smoke, and these substances can stimulate melanocytes to produce melanin. (medscape.com)
- High temperatures may yield more oil with a stronger flavor, but it increases other substances harmful to the body such as benzo(a)pyrene. (kimcmarket.com)
PAHs1
- High levels of PAHs were seen in the fire-cured tobacco samples with a benzo[a]pyrene level of 87 ng/g. (cdc.gov)
Diolepoxide1
- The modulation of benzo[a]pyrene diolepoxide (BPDE)DNA adduct levels by polymorphisms in the CYP1A1, GSTM1 and GSTT1 genes was assessed in leukocytes of Caucasian males. (archives-ouvertes.fr)
Carcinogen1
- Human genome-wide repair map of DNA damage caused by the cigarette smoke carcinogen benzo[a]pyrene. (adebalilab.org)
Metabolites1
- Irreversible binding of isolated benzo[a]pyrene metabolites to specific rat liver microsomal proteins. (nih.gov)
Lungs1
- Alterations in the mutagenicity and mutation spectrum induced by benzo[a]pyrene instilled in the lungs of gpt delta mice of various ages. (cdc.gov)
Mice4
- In the present study, male transgenic lacI mice at different ages (7, 25 and 60 days old) were treated with a known environmental mutagen (benzo[a]pyrene, B[a]P) at different doses (0, 50, 200 or 300 mg/kg body weight). (plos.org)
- The characteristic diurnal fluctuation in epidermal cyclic AMP levels present in untreated mice was not observed after benzo( a )pyrene treatment. (aacrjournals.org)
- Non-pregnant or timed-pregnant (18th day of gestation) ICR mice of similar age were treated with benzo[a]pyrene (BP, 200 μmol/kg), safrole (600 μmol/kg), 1′-hydroxysafrole (400 μmol/kg), 4-aminobiphenyl (4-ABP, 800 μmol/kg), or trioctanoin (4 ml/kg) per os. (utmb.edu)
- Baicalein inhibits cell proliferation and enhances apoptosis in human A549 cells and benzo(a)pyrene-induced pulmonary carcinogenesis in mice. (greenmedinfo.com)
Concentrations1
- Concentrations of benzo(a)pyrene were found to compare the product of burning ordinary fuel oil and water fuel emulsion. (pjoes.com)
Descriptor1
- Benzopyrenes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uams.edu)
20181
- 2018. Pharmacokinetics of [C]-Benzo[a]pyrene (BaP) in humans: Impact of Co-Administration of smoked salmon and BaP dietary restriction. . (oregonstate.edu)
Harmful1
- The World Health Organization (WHO) considers even the tiniest dose of benzo(a)pyrene harmful. (empa.ch)
Emissions1
- WASHINGTON (CN) - Emissions of carbonyl sulfide and polycyclic organic matter like benzo[a]pyrene from aluminum reduction plants would be regulated for the first time under new rules proposed by the Environmental Protection Agency. (courthousenews.com)
Mutagenicity1
- In the present study, the effects of MMA on the mutagenicity of 1-nitropyrene (1-NP) and benzo[a]pyrene (B[a]P) were evaluated with the Salmonella typhimurium TA98 strain in the absence and presence of S9 mix. (elsevier.com)
Lung2
- Anti-inflammatory and apoptotic signalling effect of fucoxanthin on benzo(A)pyrene-induced lung cancer. (greenmedinfo.com)
- Benzo[a]pyrene (BaP), a polycyclic aromatic hydrocarbon, is the major cause of lung cancer. (adebalilab.org)
Detection2
- The legal limit for benzo[a]pyrene, established in 1992, was based on analytical detection limits at the time that the standard was set. (ewg.org)
- This product displays the stations where benzo[A]pyrene has been measured and the values present in EMODnet Chemistry infrastructure are always above the limit of detection or quantification (LOD/LOQ), i.e quality value equal to 1. (marine-analyst.eu)
Liver1
- Covalent binding of benzo[a]pyrene to rat liver cytosolic proteins and its effect on the binding to microsomal proteins. (nih.gov)
Characteristics2
- pyrene in Contaminated Sites: Sectoral Characteristics, Temporal Trends, and Empirical Implications. (bvsalud.org)
- Risk Control Values and Remediation Goals for Benzo[ a ]pyrene in Contaminated Sites: Sectoral Characteristics, Temporal Trends, and Empirical Implications. (bvsalud.org)
Human2
- Reference: Characterization of human DNA polymerase κ promoter in response to benzo[a]pyrene diol epoxide. (neb.com)
- Studies have also found that nicotine and tobacco-specific compounds (N -nitrosamines and benzopyrene) may accumulate in melanin-containing human tissues and affect melanogenesis. (medscape.com)
Method4
- Determination of the concentration of benzo(a)pyrene in samples of flue gases of DKVR-4/13 and PTVM- 30M boiler units of the Teplokommunoenergo heating organization of Bishkek city was carried out by chromatographic method. (pjoes.com)
- I developed a preliminary method for measuring in situ benzo(a)pyrene (BaP) accumulation by phytoplankton using laboratory studies and natural assemblages of Lake Whatcom (Bellingham, WA) phytoplankton. (wwu.edu)
- A rapid and sensitive method for determination of covalent binding of benzo[a]pyrene to proteins. (nih.gov)
- So they opted to use a healthier press method that may yield less, but that ensures no benzo(a)pyrenees are produced. (kimcmarket.com)
Gene1
- CYP1B1 mRNA inducibility due to benzo(a)pyrene is modified by the CYP1B1 L432V gene polymorphism. (cdc.gov)
Levels1
- Topical application of benzo( a )pyrene caused a rise in the basal levels of cyclic AMP and a decreased response to isoproterenol, either injected i.p. or added to a salts medium containing skin pieces. (aacrjournals.org)
Formation1
- These elements are the key elements of benzo(a)pyrene formation. (pjoes.com)
Publications2
- This graph shows the total number of publications written about "Benzopyrenes" by people in UAMS Profiles by year, and whether "Benzopyrenes" was a major or minor topic of these publications. (uams.edu)
- Below are the most recent publications written about "Benzopyrenes" by people in Profiles over the past ten years. (uams.edu)
Damage2
- Assessment of the protective effects of selected dietary anticarcinogens against DNA damage and cytogenetic effects induced by benzo[a]pyrene. (greenmedinfo.com)
- The ERCC2/XPD Lys751Gln polymorphism affects DNA repair of benzo[a]pyrene induced damage, tested in an in vitro model. (cdc.gov)
Effect2
- The effect of benzo( a )pyrene on the accumulation of cyclic adenosine 3′,5′-monophosphate (cyclic AMP) in mouse skin in response to isoproterenol has been measured. (aacrjournals.org)
- Antineoplaston A10 has a chempreventive effect on benzo(a)pyrene-induced pulmonary neoplasia. (greenmedinfo.com)
Level1
- The EWG Health Guideline of 0.007 ppb for benzo[a]pyrene was defined by the California Office of Environmental Health Hazard Assessment as a public health goal, the level of a drinking water contaminant that does not pose a significant health risk. (ewg.org)
Annual1
- For references , please go to https://www.eea.europa.eu/data-and-maps/figures/benzo-a-pyrene-annual or scan the QR code. (europa.eu)
Environmental1
- Benzo[a]pyrene (B[a]P) is a ubiquitous polycyclic aromatic hydrocarbon (PAH) and environmental mutagen. (plos.org)
![EWG Tap Water Database | Edgemont Ranch Md | Benzo[a]pyrene](https://static.ewg.org/reports/2017/tap-water/img/EWG_Social_Share_TWDB_Contaminants.jpg)
