A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.
A group of condensed ring hydrocarbons.
A class of chemicals that contain an anthracene ring with a naphthalene ring attached to it.
7,8,8a,9a-Tetrahydrobenzo(10,11)chryseno (3,4-b)oxirene-7,8-diol. A benzopyrene derivative with carcinogenic and mutagenic activity.
Benzopyrenes saturated in any two adjacent positions and substituted with two hydroxyl groups in any position. The majority of these compounds have carcinogenic or mutagenic activity.
The products of chemical reactions that result in the addition of extraneous chemical groups to DNA.
A major group of unsaturated cyclic hydrocarbons containing two or more rings. The vast number of compounds of this important group, derived chiefly from petroleum and coal tar, are rather highly reactive and chemically versatile. The name is due to the strong and not unpleasant odor characteristic of most substances of this nature. (From Hawley's Condensed Chemical Dictionary, 12th ed, p96)
Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.
Compounds consisting of two or more fused ring structures.
Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes.
The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
A drug-metabolizing, cytochrome P-448 (P-450) enzyme which catalyzes the hydroxylation of benzopyrene to 3-hydroxybenzopyrene in the presence of reduced flavoprotein and molecular oxygen. Also acts on certain anthracene derivatives. An aspect of EC 1.14.14.1.
A carcinogen that is often used in experimental cancer studies.
Organic compounds that include a cyclic ether with three ring atoms in their structure. They are commonly used as precursors for POLYMERS such as EPOXY RESINS.
Four fused benzyl rings with three linear and one angular, that can be viewed as a benzyl-phenanthrenes. Compare with NAPHTHACENES which are four linear rings.
A liver microsomal cytochrome P-450 monooxygenase capable of biotransforming xenobiotics such as polycyclic hydrocarbons and halogenated aromatic hydrocarbons into carcinogenic or mutagenic compounds. They have been found in mammals and fish. This enzyme, encoded by CYP1A1 gene, can be measured by using ethoxyresorufin as a substrate for the ethoxyresorufin O-deethylase activity.
Tests of chemical substances and physical agents for mutagenic potential. They include microbial, insect, mammalian cell, and whole animal tests.
1,2-Benzphenanthrenes. POLYCYCLIC COMPOUNDS obtained from coal tar.
A by-product of the destructive distillation of coal used as a topical antieczematic. It is an antipruritic and keratoplastic agent used also in the treatment of psoriasis and other skin conditions. Occupational exposure to soots, tars, and certain mineral oils is known to be carcinogenic according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985) (Merck Index, 11th ed).
Carcinogenic substances that are found in the environment.
A large group of cytochrome P-450 (heme-thiolate) monooxygenases that complex with NAD(P)H-FLAVIN OXIDOREDUCTASE in numerous mixed-function oxidations of aromatic compounds. They catalyze hydroxylation of a broad spectrum of substrates and are important in the metabolism of steroids, drugs, and toxins such as PHENOBARBITAL, carcinogens, and insecticides.
Organic compounds containing a BENZENE ring attached to a flavone group. Some of these are potent arylhydrocarbon hydroxylase inhibitors. They may also inhibit the binding of NUCLEIC ACIDS to BENZOPYRENES and related compounds. The designation includes all isomers; the 7,8-isomer is most frequently encountered.
A generic grouping for dihydric alcohols with the hydroxy groups (-OH) located on different carbon atoms. They are viscous liquids with high boiling points for their molecular weights.
A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Cytoplasmic proteins that bind certain aryl hydrocarbons, translocate to the nucleus, and activate transcription of particular DNA segments. AH receptors are identified by their high-affinity binding to several carcinogenic or teratogenic environmental chemicals including polycyclic aromatic hydrocarbons found in cigarette smoke and smog, heterocyclic amines found in cooked foods, and halogenated hydrocarbons including dioxins and polychlorinated biphenyls. No endogenous ligand has been identified, but an unknown natural messenger with a role in cell differentiation and development is suspected.
A group of compounds that are derivatives of methoxybenzene and contain the general formula R-C7H7O.
A greasy substance with a smoky odor and burned taste created by high temperature treatment of BEECH and other WOOD; COAL TAR; or resin of the CREOSOTE BUSH. It contains CRESOLS and POLYCYCLIC AROMATIC HYDROCARBONS which are CARCINOGENS. It has been widely used as wood preservative and in PESTICIDES and had former use medicinally in DISINFECTANTS; LAXATIVES; and DERMATOLOGIC AGENTS.
An increase in the rate of synthesis of an enzyme due to the presence of an inducer which acts to derepress the gene responsible for enzyme synthesis.
Reduction of pharmacologic activity or toxicity of a drug or other foreign substance by a living system, usually by enzymatic action. It includes those metabolic transformations that make the substance more soluble for faster renal excretion.
A potent epoxide hydrase and aryl hydrocarbon hydroxylase inhibitor. It enhances the tumor-initiating ability of certain carcinogens.
A polyaromatic hydrocarbon inducer of P4501A1 and P4501A2 cytochromes. (Proc Soc Exp Biol Med 1994 Dec:207(3):302-308)
A family of diphenylenemethane derivatives.
A circumscribed benign epithelial tumor projecting from the surrounding surface; more precisely, a benign epithelial neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic cells. (Stedman, 25th ed)
A nucleoside consisting of the base guanine and the sugar deoxyribose.
Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.
The combination of two or more different factors in the production of cancer.
Elimination of ENVIRONMENTAL POLLUTANTS; PESTICIDES and other waste using living organisms, usually involving intervention of environmental or sanitation engineers.
A chemical by-product that results from burning or incinerating chlorinated industrial chemicals and other hydrocarbons. This compound is considered an environmental toxin, and may pose reproductive, as well as, other health risks for animals and humans.
Substances or energies, for example heat or light, which when introduced into the air, water, or land threaten life or health of individuals or ECOSYSTEMS.
A residue of coal, left after dry (destructive) distillation, used as a fuel.
7,12-Dimethylbenzanthracene. Polycyclic aromatic hydrocarbon found in tobacco smoke that is a potent carcinogen.
Family of small, surface-dwelling fish that inhabit fresh and brackish waters, and coastal marine areas.
Compounds of the general formula R-O-R arranged in a ring or crown formation.
A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.
Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.
Measurement of the intensity and quality of fluorescence.
Mixture of 2- and 3-tert-butyl-4-methoxyphenols that is used as an antioxidant in foods, cosmetics, and pharmaceuticals.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. They may be smooth or rough.
Industrial chemicals which have become widespread environmental pollutants. Each aroclor is a mixture of chlorinated biphenyls (1200 series) or chlorinated terphenyls (5400 series) or a combination of both (4400 series).
Mistry, A. (31 May 2012). "Dehydration of 3,4-dihydro-5H-Benzo[cd]pyren-5-ol; 6H-Benzo[cd]pyrene". ChemSpider. Royal Society of ... Benzo[cd]pyrenes". Chemistry: A European Journal. 21 (5): 2011-2018. doi:10.1002/chem.201404877. Palmer, J. (28 May 2012). "' ... On reduction of this ketone using lithium aluminium hydride the alcohol 3,4-dihydro-5H-benzo[cd]pyren-5-ol was obtained, the 3, ... A very similar molecule (benzo[c]phenanthrene) which lacks the -CH2- spacer between the two sides of the molecule has been ...
Benzo(a)pyrene " 0.010 μg/l 0.2 μg/l 0.0028 μg/l " ...
... ranged from 6 to 88 mg/kg and fluoranthene and pyrene were generally the most abundant PAHs.[63] Benzo[a]pyrene (BaP), the most ... An adduct formed between a DNA strand and an epoxide derived from a benzo[a]pyrene molecule (center); such adducts may ... Mutagenic PAHs, such as benzo[a]pyrene, usually have four or more aromatic rings as well as a "bay region", a structural pocket ... Polycyclic aromatic hydrocarbons (e.g., 3-methylcholanthrene, benzo[a]pyrene, benzanthracenes, benzoflavones (e.g., beta- ...
Benzo[α]pyrene interacts with deoxyguanosine of the DNA, damaging it and potentially starting the processes that can lead to ... benzo[α]pyrene. DNA consists of sequences of four bases - guanine, adenine, cytosine, and thymine - bound to a deoxyribonucleic ...
Rentz JA, Alvarez PJ, Schnoor JL (February 2008). "Benzo[a]pyrene degradation by Sphingomonas yanoikuyae JAR02". Environmental ...
Benzopyrene diol epoxide, an extremely carcinogenic (cancer-causing) metabolite of benzopyrene, a polycyclic aromatic ... pyrene in a fully complementary DNA duplex: evidence for a major syn conformation". Biochemistry. 40 (20): 5870-81. doi:10.1021 ... "DNA interaction with Benzopyrene". DNA. Archived from the original on December 23, 2004. Retrieved March 5, 2005.. ... The first PAH to be identified as a carcinogen in tobacco smoke was benzopyrene, which has been shown to toxicate into an ...
Alam S, Conway MJ, Chen HS, Meyers C (January 2008). "The cigarette smoke carcinogen benzo[a]pyrene enhances human ...
"Cigarette Smoke Carcinogen Benzo[a]pyrene Enhances Human Papillomavirus Synthesis". J Virol. 82 (2): 1053-8. doi:10.1128/JVI. ...
Luo, Y. R.; Kang, S. G.; Kim, S.-J.; Kim, M.-R.; Li, N.; Lee, J.-H.; Kwon, K. K. (2012). "Genome Sequence of Benzo(a)pyrene- ...
Perylene is less toxic than its well-studied cousin benzo[a]pyrene. Little is actually known about the mechanistic toxicology ...
This was identified as 3:4-benzo(a)pyrene, and highly carcinogenic. The discovery confirmed concerns over the correlation ...
Mineralizes phenanthrene, fluoranthene, and pyrene, but not anthracene or benzo[a]pyrene. Differential characteristics The ... Etymology: pyrenivorans; digesting pyrene. Microscopy Gram-positive, acid-fast rods. Colony characteristics The rough colonies ...
... benzo[a]pyrene, studied as a carcinogen, or retene), terpenes. It also results in the emission of a range of smaller oxygenated ...
Lee CM, Chen SY, Lee YC, Huang CY, Chen YM (July 2006). "Benzo[a]pyrene and glycine N-methyltransferse interactions: gene ... "Glycine N-methyltransferase tumor susceptibility gene in the benzo(a)pyrene-detoxification pathway". Cancer Research. 64 (10): ...
Benzopyrene is also converted to an epoxide, (+)-benzo[a]pyrene-7,8-epoxide. Benzene oxide (C6H6O) exists as an equilibrium ...
"Cell specificity in metabolic activation of aflatoxin B1 and benzo(a)pyrene to mutagens for mammalian cells". Nature. 276 (5685 ... "Cell susceptibility to transformation and cytotoxicity by the carcinogenic hydrocarbon benzo[a]pyrene". PNAS. 56 (5): 1123-1129 ...
benzo(a)pyrene. IARC Group 1 carcinogen. 208-558[37][39]. fluoranthene[1]. IARC Group 3 possible carcinogens 3399-7321[37][39] ...
... ranged from 6 to 88 mg/kg and fluoranthene and pyrene were generally the most abundant PAHs.[63] Benzo[a]pyrene (BaP), the most ... An adduct formed between a DNA strand and an epoxide derived from a benzo[a]pyrene molecule (center); such adducts may ... Mutagenic PAHs, such as benzo[a]pyrene, usually have four or more aromatic rings as well as a "bay region", a structural pocket ... Hewett and Hieger then linked the specific spectroscopic fluorescent profile of benzo[a]pyrene to that of the carcinogenic ...
Substrates of this enzyme include estrone, 2-hydroxyestrone, and metabolites of benzo(a)pyrene. GRCh38: Ensembl release 89: ...
... is estimated to have about 1% of the toxicity of benzo(a)pyrene. Derivatives of chrysene include tetrahydrochrysene ...
Deoxyguanosine is used in the figure, since that base appears to be bound to Benzo[a]pyrene far more often than the other bases ... The mechanism is derived from the binding mechanism of benzo[a]pyrene to DNA. This is likely because it is plausible that two ... "Comparison of the in vitro mutagenicity and metabolism of dimethylnitrosamine and benzo[a]pyrene in tissues from inbred mice ...
"Aberrant expression of miR-638 contributes to benzo(a)pyrene-induced human cell transformation". Toxicological Sciences. 125 (2 ...
"Interindividual variation in binding of benzo[a]pyrene to DNA in cultured human bronchi". Science. 194 (4269): 1067-1069. doi: ...
Furthermore, her research showed that the effects of benzo(a)pyrene, which is present in tobacco smoke and grilled meats, are ... Shockley studied how pollutants such as benzo(a)pyrene and fluoranthene affect the nervous system. Her research showed that ... Saunders, Crystal R.; Das, Salil K.; Ramesh, Aramandla; Shockley, Dolores C.; Mukherjee, Shyamali (2006). "Benzo(a)pyrene- ... "Modulation of neurotoxic behavior in F-344 rats by temporal disposition of benzo(a)pyrene". Toxicology Letters. 129 (1): 33-45 ...
Aluminum smelters typically discharge fluoride, benzo(a)pyrene, antimony and nickel, as well as aluminum. Copper smelters ...
... benzo[a]pyrene), and metals" have not been assessed. However, Star Scientific notes, "there is currently no proof that lowering ...
Zheng Z, Fang JL, Lazarus P (2002). "Glucuronidation: an important mechanism for detoxification of benzo[a]pyrene metabolites ...
An example is benzo(a)pyrene that is metabolized in two steps, oxidation and conjugation. Oxidation produces epoxide ... carcinogenic polycyclic hydrocarbons such as benzo(a)pyrene. These polycyclic hydrocarbons also activate the AH receptor, but ...
... anthracene and benzo(a)pyrene. The cleanup goal of benzo(a)anthracene and benzo(a)pyrene was set at a soil concentration of ... The cleanup goal of benzo(a)anthracene and benzo(a)pyrene was achieved. OU2 dealt with building a new Coraopolis Bridge on top ... benzo(a)pyrene, benzo(a)anthracene, dibenz(a,h)antharacene, 4-methylphenol, 2,4-dichlorophenol, 2,4,6-trichlorophenol, dieldrin ... The soil contaminants of concern in 1996 were benzo(a) ...
Some of the chemicals released in this process are benzo(a)pyrene and other polyaromatic hydrocarbons. These fumes pollute the ...
"benzo[a]pyrene". pubchem.ncbi.nlm.nih.gov.. *^ Assessment of Benzo-alpha-pyrene Emissions in the Great Lakes Region, pp 23-24 ... Benzo[a]pyrene is first oxidized by cytochrome P450 1A1 to form a variety of products, including (+)benzo[a]pyrene-7,8-epoxide. ... benz[a]pyrene. 3,4-benzpyrene. 3,4-benzopyrene. 3,4-benz[a]pyrene. 3,4-benzo[a]pyrene ... Benzo[a]pyrene, showing the base pyrene ring and numbering and ring fusion locations according to IUPAC nomenclature of organic ...
Crystal and molecular structure of a benzo-a-pyrene 7,8-diol 9,10-epoxide N2-deoxyguanosine adduct: Absolute configuration and ... Benzo(a)fluoranten (C20H12) • Benzo(b)fluoranten (C20H12) • Benzo(j)fluoranten (C20H12) • Benzo(k)fluoranten (C20H12) • Perylen ... Tricyklobutabenzen (C12H12) • Tetracen (C18H12) • Benzo(a)antracen (C18H12) • Pyren (C16H10) • Benzo(a)fluoren (C17H12) • Benzo ... Zdroje benzo[a]pyrenu[editovat , editovat zdroj]. Benzo[a]pyren se nachází v uhelném dehtu, v automobilových výfukových plynech ...
... benzo(a)anthracene, benzo(b)fluoranthene, benzo(k)fluoranthene, benzo(a)pyrene, indeno(cd)pyrene, phenanthrene, anthracene, and ... Toxicological data (Tox) has been published for each of these contaminants as well as for benzo[a]pyrene, benzene, dioxins, ... such as naphthalene and benzo(a)pyrene), solvents, pesticides, lead, and other heavy metals. Contamination is correlated with ...
... which is a key enzyme in detoxication of carcinogenic polycyclic aromatic hydrocarbons such as benzo(a)pyrene.[9] ... Uno S, Dalton TP, Dragin N, Curran CP, Derkenne S, Miller ML, Shertzer HG, Gonzalez FJ, Nebert DW (April 2006). "Oral benzo[a] ... pyrene in Cyp1 knockout mouse lines: CYP1A1 important in detoxication, CYP1B1 metabolism required for immune damage independent ...
"benzo[a]pyrene". pubchem.ncbi.nlm.nih.gov.. *^ Assessment of Benzo-alpha-pyrene Emissions in the Great Lakes Region, pp 23-24 ... benz[a]pyrene. 3,4-benzpyrene. 3,4-benzopyrene. 3,4-benz[a]pyrene. 3,4-benzo[a]pyrene. pentacyclo[10.6.2.02,7.09,19.016,20] ... Benzo[a]pyrene is first oxidized by cytochrome P450 1A1 to form a variety of products, including (+)benzo[a]pyrene-7,8-epoxide. ... Benzo[a]pyrene, showing the base pyrene ring and numbering and ring fusion locations according to IUPAC nomenclature of organic ...
Polycyclic aromatic hydrocarbons (e.g., 3-methylcholanthrene, benzo[a]pyrene, benzanthracenes, benzoflavones (e.g., beta- ... carcinogenic polycyclic hydrocarbons such as benzo(a)pyrene (but making many of them more toxic in the process).[11] ...
Benzo[a]pyrene. *1,3-Butadiene. *Diethylstilbestrol. *Formaldehyde. *Ionizing radiation (e.g., from isotopes of plutonium and ...
Polycyclic aromatic hydrocarbons (e.g., 3-methylcholanthrene, benzo[a]pyrene, benzanthracenes, benzoflavones (e.g., beta- ...
Polycyclic aromatic hydrocarbons (e.g., 3-methylcholanthrene, benzo[a]pyrene, benzanthracenes, benzoflavones (e.g., beta- ...
This is the mechanism behind the carcinogenicity of benzo[a]pyrene in tobacco smoke, other aromatics, aflatoxin and mustard gas ... Potent carcinogens found in cigarette smoke include polycyclic aromatic hydrocarbons (PAH, such as benzo[a]pyrene), Benzene, ... benzo[a]pyrene).[16] Charring of food looks like coking and tobacco pyrolysis, and produces carcinogens. There are several ... including benzo[a]pyrene, tobacco-specific nitrosamines such as nitrosonornicotine, and reactive aldehydes such as formaldehyde ...
... including benzo[a]pyrene,[25] NNK, 1,3-butadiene and a radioactive isotope of polonium, polonium-210.[24] Across the developed ...
... fluoranthene Benzo[a]fluorene Benzo[b]fluorene Benzo[c]fluorene Benzo[ghi]perylene Benzo[c]phenanthrene Benzo[e]pyrene p- ... acridine Benzo[g]chrysene Benzo[a]fluoranthene Benzo[ghi] ... Propham n-Propyl carbamate Propylene Ptaquiloside Pyrene ... pyrene Dibenzo[e,l]pyrene Dibromoacetonitrile Dichloroacetonitrile Dichloroacetylene m-Dichlorobenzene o-Dichlorobenzene trans- ... pyrene 1-Naphthylamine 1-Naphthylthiourea (ANTU) Nithiazide 5-Nitro-ortho-anisidine 9-Nitroanthracene 7-Nitrobenz[a]anthracene ...
... and dyes metabolized to Benzo[a]pyrene Beryllium and beryllium compounds2 Chlornapazine (N,N-Bis(2-chloroethyl)-2-naphthylamine ...
Anderson KE, Kadlubar FF, Kulldorff M, et al. (2005). "Dietary intake of heterocyclic amines and benzo(a)pyrene: associations ...
drug and steroid (especially estrogen) metabolism, benzo[a]pyrene toxification (forming (+)-benzo[a]pyrene-7,8-dihydrodiol-9,10 ...
A covalent adduct between a metabolically activated form of benzo[a]pyrene, the major mutagen in tobacco smoke, and DNA[74] ... Others such as benzo[a]pyrene diol epoxide and aflatoxin form DNA adducts that induce errors in replication.[86] Nevertheless, ...
A covalent adduct between the metabolite of benzo[a]pyrene, the major mutagen in tobacco smoke, and DNA[52] ...
Ang iba gaya ng benzo[a]pyrene diol epoxide at aflatoxin ay bumubuo ng DNA adducts na pumupukaw ng mga pagkakamali at ...
... benzo[a]pyrene).[31] However, these potential carcinogenic compounds originated from the commercial drying process of the mate ...
... pyrene-induced stomach tumors". Proc. Natl. Acad. Sci. U.S.A. 99 (11): 7610-5. Bibcode:2002PNAS...99.7610F. doi:10.1073/pnas. ... "Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo ...
Benzo[a]pyrene. *Bisphenol A. *1,3-Butadiene. *Diethylstilbestrol. *Formaldehyde. *Ionizing radiation (e.g., from isotopes of ...
2005). "Dietary intake of heterocyclic amines and benzo(a)pyrene: associations with pancreatic cancer". Cancer Epidemiol. ...
... benzo[a]pyrene, studied as a carcinogen, or retene), terpenes.[9] Heterocyclic compounds may be also present.[10] Heavier ...
Some pollutant chemicals that have been found in the lake include DDT, benzo[a]pyrene and other pesticides; PCBs, aramite, ...
Although several carcinogens were already known at the time (for example, benzo[a]pyrene was isolated from coal tar and ...
benz[a]pyrene. 3,4-benzpyrene. 3,4-benzopyrene. 3,4-benz[a]pyrene. 3,4-benzo[a]pyrene ... "benzo[a]pyrene". pubchem.ncbi.nlm.nih.gov.. *^ Assessment of Benzo-alpha-pyrene Emissions in the Great Lakes Region, pp 23-24 ... Benzo[a]pyrene is first oxidized by cytochrome P450 1A1 to form a variety of products, including (+)benzo[a]pyrene-7,8-epoxide. ... Benzo[a]pyrene, showing the base pyrene ring and numbering and ring fusion locations according to IUPAC nomenclature of organic ...
benz[a]pyrene. 3,4-benzpyrene. 3,4-benzopyrene. 3,4-benz[a]pyrene. 3,4-benzo[a]pyrene. pentacyclo[10.6.2.02,7.09,19.016,20] ... "benzo[a]pyrene". pubchem.ncbi.nlm.nih.gov.. *^ Assessment of Benzo-alpha-pyrene Emissions in the Great Lakes Region, pp 23-24 ... Benzo[a]pyrene is first oxidized by cytochrome P450 1A1 to form a variety of products, including (+)benzo[a]pyrene-7,8-epoxide. ... Benzo[a]pyrene, showing the base pyrene ring and numbering and ring fusion locations according to IUPAC nomenclature of organic ...
Other names: Benz[a]pyrene; 1,2-Benzpyrene; 3,4-Benzopyrene; 3,4-Benzpyrene; 3,4-Benz[a]pyrene; 6,7-Benzopyrene; Benzo[d,e,f] ... The ground-state electronic structure of aryloxiranes and metabolites of benzo[a]pyrene, J. Phys. Chem., 1979, 83, 2997. [all ... The pyrene series, Tetrahedron, 1979, 35, 1027. [all data] Akiyama, Li, et al., 1979. Akiyama, I.; Li, K.C.; LeBreton, P.R.; Fu ... chrysene; B(a)P; BP; 3,4-Benzopirene; 3,4-Benzpyren; 3,4-BP; Rcra waste number U022; Benzopyrene; 4,5-Benzpyrene; NSC 21914; ...
Other names: Benz[a]pyrene; 1,2-Benzpyrene; 3,4-Benzopyrene; 3,4-Benzpyrene; 3,4-Benz[a]pyrene; 6,7-Benzopyrene; Benzo[d,e,f] ... chrysene; B(a)P; BP; 3,4-Benzopirene; 3,4-Benzpyren; 3,4-BP; Rcra waste number U022; Benzopyrene; 4,5-Benzpyrene; NSC 21914; ...
... is a pyrenes (CHEBI:59659) ... Benzo[a]pyrene-7,8-dihydrodiol KEGG COMPOUND Benzo[a]pyrene-7,8 ... CHEBI:34562 - Benzo[a]pyrene-7,8-diol. Main. ChEBI Ontology. Automatic Xrefs. Reactions. Pathways. Models. ...
Benz(a)pyrene. 3,4-Benzopyrene. Benzo(d,e,f)chrysene. April 2014. ... Benzo(a)pyrene is present as a component of polycyclic aromatic hydrocarbons (PAHs) in the environment, usually resulting from ... See Also: Toxicological Abbreviations Benzo(a)Pyrene (IARC Summary & Evaluation, Volume 3, 1973) ...
Benzopyrene Benzo[a]pyrene Benzene Pyrene, a four-ring analogue v t e. ... Benzo[e]pyrene is a polycyclic aromatic hydrocarbon with the chemical formula C20H12. It is listed as a Group 3 carcinogen by ...
Benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide is the carcinogenic product of three enzymatic reactions: Benzo[a]pyrene is first ... Benzopyrene Benzo[e]pyrene Pyrene, a four-ring analogue Toxification Henri A. Favre, Warren H. Powell (2013). Nomenclature of ... ISBN 978-1-4987-5429-3. "benzo[a]pyrene". pubchem.ncbi.nlm.nih.gov. Assessment of Benzo-alpha-pyrene Emissions in the Great ... pyrene-7,8-epoxide. This product is metabolized by epoxide hydrolase, opening up the epoxide ring to yield (−)benzo[a]pyrene-7, ...
... pyrene results for Owensboro Municipal Utilities , Benzo[a]pyrene. Find out what is in your tap water ... Benzo[a]pyrene. Owensboro Municipal Utilities. Benzo[a]pyrene is a polycyclic aromatic hydrocarbon, or PAH, released from ... The EWG Health Guideline of 0.007 ppb for benzo[a]pyrene was defined by the California Office of Environmental Health Hazard ... The legal limit for benzo[a]pyrene, established in 1992, was based on analytical detection limits at the time that the standard ...
and known to be a cause of cancer in animalssometimes called benz·py′rene Origin of benzopyrene benzo- + pyrene... ... benzopyrene definition: an aromatic hydrocarbon, CH, found in coal tar, cigarette smoke, etc. ... benzopyrene. ben·zo·py·rene. an aromatic hydrocarbon, CH, found in coal tar, cigarette smoke, etc. and known to be a cause of ... plural benzopyrenes) (Properly: benzo[a]pyrene). *(organic chemistry) A polycyclic aromatic hydrocarbon (having five fused ...
Tag Archives: benzo[a]pyrene. The Dose Makes the Poison - or does it?. By Kacee Deener ... Tagged benzo[a]pyrene, dose response, EPAs Integrated Risk Information System (IRIS) Program, exposure, Human Health Risk ... Tagged 1, 4-dioxane (inhalation update), benzo[a]pyrene, biphenyl, ETBE, ethylene oxide, formaldehyde, Gina McCarthy, health ... Until then, check out an example of dose-response assessment in Section 2 of the IRIS assessment of benzo[a]pyrene. And read ...
... pyrene is a potent carcinogen and mutagen present in cigarette smoke, automotive exhaust, burnt wood fumes, barbecued and ... pyrene and was renewed daily with the latter. Because benzo[a]pyrene is absorbed rapidly and biotransformed, it has to be ... Benzo[a]pyrene is a potent carcinogen and mutagen present in cigarette smoke, automotive exhaust, burnt wood fumes, barbecued ... Understanding the connection between benzo[a]pyrene and tumoral development. At the end of the seven-day period, the cells were ...
Benzo[a]pyrene (BaP). CASRN 50-32-8. *Toxicological Review (PDF) (234 pp, 4.67 M) ... Under EPAs Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005a), benzo[a]pyrene is "carcinogenic to humans" based on ... Sep 2016: IRIS Toxicological Review of Benzo[a]pyrene (Interagency Science Discussion Draft) (Report) ... Jun 2011: IRIS Toxicological Review of Benzo[a]pyrene (Interagency Science Consultation Draft) (Report) ...
Land developers and remediators in Pennsylvania and New Jersey may soon have an easier time addressing soils containing benzo[a ... Benzo[a]pyrene is a polynuclear aromatic hydrocarbon (PAH) and is found as the result of the combustion of organic matter such ... Benzo[a]pyrene is often the highest-risk contaminant at sites impacted by PAHs and historic fill materials such as ash, and ... While the Final Assessment concludes that benzo[a]pyrene is still a potent carcinogen, the revised parameters show that the ...
... pyrene-induced Toxicity indicating that the following substances may be helpful: Curcumin, Quercetin, and Rutin ... This topic contains 31 study abstracts on Benzo[a] ... Diseases : Benzo[a]pyrene-induced Toxicity , Oxidative Stress. ... Additional Keywords : Beet, Benzo(a)pyrene, Betaine, lung cancer, Vinyl Carbamate. Problem Substances : Benzo(a)pyrene, Vinyl ... Diseases : Benzo[a]pyrene-induced Toxicity , Lung Cancer. Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, ...
... pyrene-7,8-dione , C20H10O2 , CID 105020 - structure, chemical names, physical and chemical properties, classification, patents ...
... pyrene testing. Laboratory testing for 3,4-Benzopyrene 50-32-8. 200-028-5 is yellow crystals or powder [found in cigarette ... Synonyms: Benz[a]pyrene;1,2-Benzpyrene;3,4-Benzopyrene;3,4-Benzpyrene;3,4-Benz[a]pyrene;6,7-Benzopyrene;Benzo[«alpha»]pyrene; ... Benzo(a)pyrene. ALS Environmental may or may not test for Benzo(a)pyrene (CAS # 50-32-8). Information is subject to change; ... Analyte: Benzo(a)pyrene. Alternate Name: 3,4-Benzopyrene. Abbreviation: BAP. CAS Number or ID: 50-32-8. Department: Organics. ...
... pyrene (CAAC-benzo[a]pyrene panel), will review this draft assessment. Details about the CAAC-Benzo[a]pyrene panel, meeting ... IRIS Toxicological Review of Benzo[a]pyrene (Public Comment Draft) * IRIS Toxicological Review of Benzo[a]pyrene (Interagency ... Benzo[a]pyrene is a five-ring polycyclic aromatic hydrocarbon that is relatively insoluble in water and has low volatility. It ... Benzo[a]pyrene (BaP). CASRN 50-32-8. *Toxicological Review (PDF) (234 pp, 4.67 M) ...
Benzo(a)pyrene - Toxicity. Toxicity. A vast number of studies over the previous three decades have documented links between ... benzopyrene toxicity results from the bioactivation of benzopyrene to the ultimate toxic compound, benzopyrene -7,8-dihydrodiol ... Benzopyrene, found in tobacco smoke (including cigarette smoke), was shown to cause genetic damage in lung cells that was ... Thus in most cases small amounts of benzopyrene are metabolized by gut enzymes prior to being passed on to the blood. The lungs ...
Benzo(a)pyrene. Synonyms: 3,4-Benz(a)pyrene. 3,4-Benzopyrene. 3,4-Benzpyrene. 6,7-Benzopyrene. Benzo(d,e,f)chrysene. B(a)P. BP ... Epidermal hyperplasia after topical application of benzo(a)pyrene, benzo(a)pyrene diol epoxides, and other metabolites. Cancer ... 10-fluoro-benzo(j)fluoranthene, benzo(a)pyrene, dibenzo(a,l)pyrene and 7,12-dimethylbenz(a)anthracene. Cancer Letter. Vol. 70 ( ... Tumor-initiating activity and carcinogenicity of dibenzo(a,l)pyrene versus 7,12-dimethylbenz(a)anthracene and benzo(a)pyrene at ...
Benzo(a)pyrene is present as a component of polycyclic aromatic hydrocarbons (PAHs) in the environment, usually resulting from ... Benz(a)pyrene 3,4-Benzopyrene Benzo(d,e,f)chrysene CAS # 50-32-8 C20H12 ...
Fisetin modulates mitochondrial enzymes and apoptotic signals in benzo(a)pyrene-induced lung cancer.. Ravichandran N1, Suresh G ... pyrene (B(a)P) as the model lung carcinogen. The recent revival of interest in the study of mitochondria has been stimulated by ... mechanisms of orally administered fisetin with special reference to mitochondrial dysfunction in lung tissues employing benzo(a ...
... to rats on the pulmonary microsomal metabolism of benzo(a)pyrene (50328) (BP) was examined. Male Sprague-Dawley-rats were ... The effects of administering silica (14808607) to rats on the pulmonary microsomal metabolism of benzo(a)pyrene (50328) (BP) ... Pulmonary microsomal metabolism of benzo(a)pyrene following exposure of rats to silica.. ... NIOSH-Author; Pyrenes; Laboratory-animals; Silicates; Lung-cancer; Microsomal-enzymes; Lung-disorders; Lung-irritants; ...
... pyrene (50328) (BaP) to a protein in rat liver cytosol facilitates its oxidation by microsomal enzymes. Cytosols were prepared ... Evidence was presented to indicate that the binding of benzo(a) ... Binding of benzo(a)pyrene to hepatic cytosolic protein enhances ... Evidence was presented to indicate that the binding of benzo(a)pyrene (50328) (BaP) to a protein in rat liver cytosol ... NIOSH-Publication; NIOSH-Grant; Dermatitis; Liver-enzymes; Enzyme-activity; Metabolic-study; Pyrenes; Lipids; Carcinogens; ...
... pyrene assessed by soil microbial indicators. The ecotoxicity of benzo[a]pyrene (BaP) to soil microorganisms was evaluated ... Ecotoxicity of benzo[a]pyrene assessed by soil microbial ... Ecotoxicity of benzo[a]pyrene assessed by soil microbial ... No comments were found for Ecotoxicity of benzo[a]pyrene assessed by soil microbial indicators. Be the first to comment! ... The ecotoxicity of benzo[a]pyrene (BaP) to soil microorganisms was evaluated using the following microbial indicators: soil ...
... pyrene (B(a)P) orally on days 11, 12, 13 or 18 of pregnancy. B(a)P poorly penetrated into the embryo/fetus, and 14C- ... within maternal and embryonic/fetal mouse tissue was studied over a period of 2 days following a single dose of 14C-benzo(a) ... Transfer of benzo(a)pyrene into mouse embryos and fetuses Arch Toxicol. 1988;62(2-3):236-9. doi: 10.1007/BF00570149. ... pyrene (B(a)P) orally on days 11, 12, 13 or 18 of pregnancy. B(a)P poorly penetrated into the embryo/fetus, and 14C- ...
Chemicals/CAS: benzo[a]pyrene, 50-32-8; retinol, 68-26-8, 82445-97-4; Benzo(a)pyrene, 50-32-8; Benzopyrenes; Vitamin A, 11103- ... Biology · β-carotene · Benzo[a]pyrene · DNA adducts · DNA repair · Tracheal organ culture · Vitamin A · benzo[a]pyrene · beta ... Effect of eugenol on the mutagenicity of benzo[a]pyrene and the formation of benzo[a]pyrene-DNA adducts in the X-lacZ- ... Toxicology · Antimutagenicity · Benzo[a]pyrene · DNA adduct · Eugenol · Transgenic mouse · benzo[a]pyrene · eugenol · animal ...
Overexpression of Catalase Enhances Benzo(a)pyrene Detoxification in Endothelial Microsomes.. [Fang Yang, Hong Yang, Aramandla ... expression and diminished benzo(a)pyrene (BaP) intermediate accumulation in mouse aortic endothelial cells (MAECs). Endoplasmic ...
... pyrene phenols and dihydrodiols. UGT1A1 and UGT1A7 were found to be broadly active towards BaP metabolites. Antisera ... Four UDP-glucuronosyltransferases from the rat UGT1A family were tested for activity towards benzo[a] ... Antisera recognizing rat UGT1A1 and UGT1A7 were used to assess UGT levels in relation to UGT activity towards benzo[a]pyrene-7, ... Four UDP-glucuronosyltransferases from the rat UGT1A family were tested for activity towards benzo[a]pyrene phenols and ...
  • Benzo[ a ]pyrene is a polycyclic aromatic hydrocarbon and the result of incomplete combustion of organic matter at temperatures between 300 °C (572 °F) and 600 °C (1,112 °F). The ubiquitous compound can be found in coal tar, tobacco smoke and many foods, especially grilled meats. (wikipedia.org)
  • Benzo[ a ]pyrene (BaP) is a polycyclic aromatic hydrocarbon found in coal tar with the formula C 20 H 12 . (wikipedia.org)
  • Benzo[e]pyrene is a polycyclic aromatic hydrocarbon with the chemical formula C20H12. (wikipedia.org)
  • Benzo[a]pyrene is a polycyclic aromatic hydrocarbon, or PAH, released from combustion of fossil fuels and waste incinerators. (ewg.org)
  • Benzo[a]pyrene is a five-ring polycyclic aromatic hydrocarbon that is relatively insoluble in water and has low volatility. (epa.gov)
  • The present study has been undertaken to examine whether exposure to benzo(a)pyrene (BaP), a polycyclic aromatic hydrocarbon (PAH) compound influences the metabolism of fluoranthene (FLA), another PAH compound. (pubmedcentralcanada.ca)
  • Humans are often exposed to carcinogenic factors,some of which through the diet, such as polycyclic aromatic hydrocarbon benzo[a]pyrene via the consumptionof over-cooked meats. (waocp.org)
  • Effect of eugenol on the mutagenicity of benzo[a]pyrene and the formation of benzo[a]pyrene-DNA adducts in the X-lacZ-transgenic mouse. (tudelft.nl)
  • We review studies which investigate the presence, using structure-specific analytical methods, of DNA or protein adducts of the carcinogen benzo[a]pyrene (BaP) in human tissues. (nih.gov)
  • Most studies reviewed here measured tetraols released from DNA or protein by hydrolysis of adducts derived from (7R,8S)-dihydroxy-(9S,10R)-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE), a major ultimate carcinogen of BaP. (nih.gov)
  • The rise between C5.G18 and S.R.S.R A6.T17 was calculated to be 7 A. The work extended the pattern for adenine N6 benzo[a]pyrene adducts, in which the R stereochemistry at C10 predicted 5'-intercalation of the pyrenyl moiety. (rcsb.org)
  • Antibodies generated against benzo(a)pyrene diol epoxide modified DNA were used to investigate adducts in skin biopsies of coal tar treated psoriasis patients. (eurekamag.com)
  • Antioxidant vitamin supplementation reduces benzo(a)pyrene-DNA adducts and potential cancer risk in female smokers. (ccceh.org)
  • Background: Elevated benzo(a)pyrene [B(a)P]-DNA adducts have been associated with 3-fold increased risk of lung cancer in current smokers. (ccceh.org)
  • Benzo (a) pyrene-albumin adducts in humans exposed to polycyclic aromatic hydrocarbons in an industrial area of Poland. (ehesp.fr)
  • Methods-Benzo (a) pyrene-diolepoxide (BPDE) - albumin adducts were measured by competitive enzyme linked immunosorbent assay (ELISA) in plasma of coke oven plant workers from three plants and from people living in a highly industrialised area of Silesia in Poland. (ehesp.fr)
  • Several solution fluorescence parameters were acquired for the four tetrol hydrolysis products of benzo[a]pyrene-trans-7,8-dihydrodiol9,10-epoxide (BPDE)-DNA adducts, tetrols complexed with DNA, and BPDE-DNA adducts in several methanol/water solvents. (osapublishing.org)
  • The antibody BAP-13 is suitable for immunocytochemical analysis of DNA and protein adducts of benzo[a]pyrene in tissues of various species. (exbio.cz)
  • Benzo pyrene-induced DNA adducts and gene expression profiles in target and non-target organs for carcinogenesis in mice. (environment-health.ac.uk)
  • Target organs for benzo[a]pyrene (BaP) carcinogenicity in mice (lung, spleen and forestomach) and three non-target organs (liver, colon and glandular stomach) were investigated for DNA adducts by 32P-postlabelling, for gene expression changes by cDNA microarray and for miRNA expression changes by miRNA microarray after exposure of animals to BaP. (environment-health.ac.uk)
  • We used an approach of global optimization of the parametersdescribing the diffusion and reaction of the ultimate carcinogenic PAHmetabolite benzo[a]pyrene diol epoxide to fit measured values from the fourV79 cell lines. (diva-portal.org)
  • In this report, we describe the characteristics of chromosomal aberrations induced in vitro by activated benzo( a )pyrene diol epoxide (BPDE) in lymphocyte cultures of 172 normal individuals ages 19-95 years and present the analysis of a pilot case-control study of 33 lung cancer patients and 96 selected controls without history of cancer and frequency matched on age (50-85 years) to the cases. (aacrjournals.org)
  • Gene profiling of normal human bronchial epithelial cells in response to asbestos and benzo(a)pyrene diol epoxide (BPDE). (biomedsearch.com)
  • Asbestos and benzo(a)pyrene diol epoxide (BPDE) are pulmonary carcinogens with synergistic interaction in causing lung cancer. (biomedsearch.com)
  • Peak E reflects almost exclusively both the cis - and trans -7,8-diol 9,10-epoxides of benzo[ a ]pyrene. (aspetjournals.org)
  • The 7,8-oxide and the 9,10-oxide contribute to peaks E, F, G, and H. Benzo[ a ] pyrene thus may be metabolized to four different "types" of reactive intermediates capable of binding to DNA: (a) primary arene oxides, (b) diol epoxides, (c) phenols oxygenated further, and (d) quinones oxygenated further (or quinone-derived free radicals). (aspetjournals.org)
  • Pulmonary microsomal metabolism of benzo(a)pyrene following exposure of rats to silica. (cdc.gov)
  • The effects of administering silica (14808607) to rats on the pulmonary microsomal metabolism of benzo(a)pyrene (50328) (BP) was examined. (cdc.gov)
  • Peak H comprises reactive intermediates resulting from the further metabolism of benzo[ a ]pyrene phenols. (aspetjournals.org)
  • K. Rudo, S. Ellis, B. J. Bryant, K. Lawrence, G. Curtis, H. Garland and S. Nesnow, Quantitative analysis of the metabolism of benzo(a)pyrene by transformable C3H10T1/2CL8 mouse embryo fibroblasts, Teratog. (springer.com)
  • Effects on 7,8-dihydroxy-9, 10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE)-DNA adduct formation were evaluated in DNA from mice treated with isothiocyanates and B[a]P, and killed 2-120h later. (eurekamag.com)
  • Whereas extensive evidence indicates that 7 beta,8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene (anti-BPDE) is a major ultimate carcinogen of benzo(a)pyrene (BaP) in mouse skin, tumorigenicity studies have consistently shown that anti-BPDE is less active then BaP in this model system. (semanticscholar.org)
  • To understand the interplay of nickel (II) and PAHs in mutagenesis and human carcinogenesis, we used a shuttle vector mutagenicity assay to examine the effect of nickel (II) on (±) anti-7β, 8α-dihydroxy-9α, 10α-epoxy-7,8,9,10-tetrahydroxybenzo[ a ]pyrene (BPDE)-induced mutagenesis in human cells. (oup.com)
  • BPDE is an activated metabolite of benzo[ a ]pyrene (BP), a major carcinogen in cigarette smoke. (oup.com)
  • Chemical agents and related occupations, Volume 10, A review of Human Carcinogens, IARC Monographs, Lyon France 2009 In June 2016, BaP was added as benzo[def]chrysene to the REACH Candidate List of Substances of very high concern for Authorisation. (wikipedia.org)
  • What most drew the scientists' attention, however, was a significant drop in the levels of metabolites involved in the production of energy for cells shortly after the first hour of exposure to benzo[a]pyrene. (news-medical.net)
  • Supplementation with nicotinamide riboside (1 μM) began 24 hours before exposure to benzo[a]pyrene and was renewed daily with the latter. (news-medical.net)
  • It has been more difficult to link cancers to specific benzopyrene sources, especially in humans, and difficult to quantify risks posed by various methods of exposure (inhalation or ingestion). (primidi.com)
  • Contact sensitization (an allergic skin reaction) has been reported in animals following short-term exposure to benzo(a)pyrene. (intox.org)
  • The objective of this study was to evaluate the reproductive risk associated with exposure of adult male Fisher-344 (F-344) rats to inhaled benzo(a)pyrene (BaP), a ubiquitous environmental toxicant present in cigarette smoke, automobile exhaust fumes and industrial emissions. (mdpi.com)
  • The infamous carcinogen benzo[a]pyrene (B[a]P) and its metabolites are often used as marker compounds to assess human exposure to total PACs and to study the development of cancer. (osapublishing.org)
  • Repeated exposure to substances containing benzo[a]pyrene may cause the skin to thicken and darken, and for pimples to appear. (burningissues.org)
  • Bronchitis may result from repeated exposure to mixtures containing benzo(a)pyrene. (burningissues.org)
  • Anyone who may have been exposed to high levels of benzo(a)pyrene should be removed from the source of exposure immediately. (burningissues.org)
  • What factors limit use or exposure to benzo(a)pyrene? (burningissues.org)
  • To study this potentially important process, the change in optical properties of laboratory-generated benzo[ a ]pyrene ( BaP )-coated aerosols following exposure to NO 2 and NO 3 was investigated at 355 nm and 532 nm by three aerosol analysis techniques. (rsc.org)
  • To determine the effectiveness of these two exposure scenarios, we studied the in vitro metabolism of two PAH compounds benzo(a)pyrene (BaP) and fluoranthene (FLA) using microsomes. (pubmedcentralcanada.ca)
  • To improve understanding of the soil-dermal exposure pathway, in vitro assessments of radiolabeled benzo[a]pyrene (BaP) absorption through human epidermis were conducted. (washington.edu)
  • Objectives-The interaction of benzo (a) pyrene with serum albumin was measured in an attempt to identify the actual exposure and to evaluate albumin adduct measurements as biomarkers for exposure monitoring. (ehesp.fr)
  • The purpose of the present study was to determine the in vivo genotoxic effects of benzo(a)pyrene [B(a)P] exposure in tissues of rats and the protective role of turmeric fed through diet. (scialert.net)
  • Under EPA's Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005a), benzo[a]pyrene is "carcinogenic to humans" based on strong and consistent evidence in animals and humans. (epa.gov)
  • We developed a food frequency questionnaire with detailed questions on meat-cooking methods and doneness levels and a benzo[ a ]pyrene (BaP) database (as a surrogate for total carcinogenic PAHs) based on the collection and analysis of a wide range of food samples. (aacrjournals.org)
  • These results suggest that conjugates of benzo(a)pyrene may be converted by beta-glucuronidase at intracellular and organ sites distal to the initial sites of oxygenation and conjugation of benzo(a)pyrene to activated intermediates that are possibly carcinogenic. (sciencemag.org)
  • The most poisonous form is benzo(a)pyrene, which is believed to be highly carcinogenic. (jrank.org)
  • In contrast, benzo(e)pyrene is not known to be carcinogenic. (jrank.org)
  • L. Pirisi, R. Garcea, R. Pascale, M. E. Ruggiu and F. Feo, Control of glucose-6-phosphate dehydrogenase deficiency on the formation of mutagenic and carcinogenic metabolites derived from benzo(a)pyrene, Toxicol. (springer.com)
  • Benzo[ a ]pyrene (B[a]P) is a well-known carcinogenic compound produced from incomplete combustion of organic compounds. (spectroscopynow.com)
  • 6-Gingerol protected against spermatotoxicity in experimental model of interaction of colitis with environmental pollutant benzo[a]pyrene. (greenmedinfo.com)
  • Benzo[ a ]pyrene (BaP) is an environmental pollutant that, based on evidence largely from in vitro studies, exerts its genotoxic effects after metabolic activation by cytochrome P450s. (springer.com)
  • Benzo(a)pyrene is on the priority pollutant list published by the U.S. Environmental Protection Agency (EPA). (burningissues.org)
  • Benzo(a)pyrene is present as a component of polycyclic aromatic hydrocarbons (PAHs) in the environment, usually resulting from the incomplete combustion or pyrolysis of organic matters, especially fossil fuels and tobacco. (inchem.org)
  • Understanding the mechanisms whereby benzo[a]pyrene, which belongs to the class of polycyclic aromatic hydrocarbons (PAHs), may induce malignant transformation of human cells is the aim of a research project supported by the São Paulo Research Foundation (FAPESP) and coordinated by Ana Paula de Melo Loureiro, a professor at the University of São Paulo's School of Pharmaceutical Sciences (FCF-USP) in Brazil. (news-medical.net)
  • Benzo[a]pyrene is often the highest-risk contaminant at sites impacted by PAHs and historic fill materials such as ash, and drives the remediation of soil that would otherwise be accepted as 'clean' for all other regulated substances. (lexology.com)
  • Benzo[ a ]pyrene (BaP) is the most commonly studied and measured of the PAHs (Arlt et al. (springer.com)
  • BACKGROUND: Polycyclic aromatic hydrocarbons (PAHs), such as benzo[a]pyrene (B[a]P), are ubiquitous toxic environmental pollutants capable of inducing cell death. (inserm.fr)
  • The revised toxicity criteria form the basis for the New Jersey Soil Remediation Standards and the Pennsylvania Statewide Health Standards, which define the acceptable default levels of benzo[a]pyrene that can be present in soil. (lexology.com)
  • A recent study has found that cytochrome P450 1A1 (CYP1A1) and cytochrome P450 1B1 (CYP1B1) are both protective and, confusingly, necessary for benzopyrene toxicity . (primidi.com)
  • Unless CYP1B1 is also knocked out, benzopyrene toxicity results from the bioactivation of benzopyrene to the ultimate toxic compound, benzopyrene -7,8-dihydrodiol-9,10-epoxide (see below). (primidi.com)
  • G6PD deficiency protects in vitro growing HSF and lymphocytes from benzo(a)pyrene (BaP) toxicity. (springer.com)
  • F. Feo, L. Pirisi, R. Pascale, L. Daino, S. Frassetto and R. Garcea, Modulatory effect of glucose-6-phosphate dehydrogenase deficiency on the benzo(a)pyrene toxicity and transforming activity for in vitro cultured human skin fibroblasts, Cancer Res. (springer.com)
  • The IRIS Toxicological Review of Benzo[a]pyrene was released for external peer review in September 2014. (epa.gov)
  • EPA initiated the interagency science consultation on the draft Toxicological Review of Benzo[a]pyrene. (epa.gov)
  • A revised interagency science consultation draft Toxicological Review of Benzo[a]pyrene was provided for further review by other federal agencies and the Executive Office of the President. (epa.gov)
  • Full Text Available This paper reports a screening results of the secondary metabolites composed in Spathodea campanulata Beauv stem bark, evaluate inhibiting activity of malondialdehyde (MDA on rat's cancer model exposed with benzopyrene , and the histology of its lung. (worldwidescience.org)
  • The isolated fraction contained of these metabolites significantly indicate bioactivity by reducting of malondialdehyde (MDA level, and also histology appearance of the lung tissue prepared from the benzopyrene -exposed rat indicated a curative activity. (worldwidescience.org)
  • S. J. Weeks, S. M. Gilles, and A. P. D'Silva, "Detection of Benzo[a]pyrene Metabolites by Laser-Excited Shpol'skii Spectrometry," Appl. (osapublishing.org)
  • After 24 hr the metabolites formed in tracheal organ cultures largely cochromatographed with tetrols, triols, and the trans -9,10-dihydro-9-10-dihydroxybenzo( a )pyrene of BP. (aacrjournals.org)
  • With the use of synthetic and biologically produced metabolites, seven of nine peaks are tentatively assigned to one or more metabolites of benzo[ a ]pyrene. (aspetjournals.org)
  • Tobacco smoke contains multiple carcinogens include polycyclic aromatic hydrocarbons typified by benzo[a]pyrene (B[a]P). Surgery is the conventional treatment approach for SCC, but it remains imperfect. (nih.gov)
  • For evaluation of the capacity for metabolism of these carcinogens in this target tissue, the conversion of the carcinogen benzo( a )pyrene (BP) to polar products was studied in tracheal organ cultures and in isolated tracheal microsomes. (aacrjournals.org)
  • The three carcinogens considered are benzo[a]pyrene, N'-nitrosonornicotine (NNN), and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). (pubmedcentralcanada.ca)
  • Peaks B, D, F, and I include products of benzo[ a ]pyrene quinones that are further metabolized. (aspetjournals.org)
  • Overexpression of Catalase Enhances Benzo(a)pyrene Detoxification in Endothelial Microsomes. (sigmaaldrich.com)
  • L. A. Reinke, P. McManus, F. C. Kauffman and R. G. Thurman, Benzo(a)-pyrene phenol production by perfused rat liver and its inhibition by ethanol, Cancer Res. (springer.com)
  • Inhibition of benzo[a]pyrene induced mutagenicity and genotoxicity by black tea polyphenols theaflavins and thearubigins in multiple test systems. (semanticscholar.org)
  • To study the possible reduction by eugenol of the mutagenicity and genotoxicity of benzoja]pyrene (B[a]P) in vivo, the X-lacZ-transgenic mouse strain 40.6 (Muta(TM)Mouse) was used. (tudelft.nl)
  • The EWG Health Guideline of 0.007 ppb for benzo[a]pyrene was defined by the California Office of Environmental Health Hazard Assessment as a public health goal, the level of a drinking water contaminant that does not pose a significant health risk. (ewg.org)
  • Until then, check out an example of dose-response assessment in Section 2 of the IRIS assessment of benzo[a]pyrene . (epa.gov)
  • The new information comes from EPA's Final Assessment of Benzo[a]pyrene , which was completed in January 2017 and is now part of EPA's Integrated Risk Information System (IRIS). (lexology.com)
  • While the Final Assessment concludes that benzo[a]pyrene is still a potent carcinogen, the revised parameters show that the chemical is not as toxicologically potent as was previously thought. (lexology.com)
  • Assessment of the protective effects of selected dietary anticarcinogens against DNA damage and cytogenetic effects induced by benzo[a]pyrene. (greenmedinfo.com)
  • The EPA's Science Advisory Board's (SAB) Chemical Assessment Advisory Committee (CAAC) conducted a peer review of the scientific basis supporting the benzo[a]pyrene assessment and released a final report of their review in April 2016. (epa.gov)
  • In September 2014, EPA submitted the draft IRIS assessment of benzo[a]pyrene (see downloads) to the agency's Science Advisory Board (SAB) for peer review and comments. (epa.gov)
  • The SAB Chemical Assessment Advisory Committee (CAAC), augmented for the review of the draft IRIS assessment of benzo[a]pyrene (CAAC-benzo[a]pyrene panel), will review this draft assessment. (epa.gov)
  • EPA announced a request for nominations for experts to augment the SAB CAAC committee for the upcoming review of the draft benzo[a]pyrene assessment. (epa.gov)
  • SAB released a list and biosketches of potential candidates to augment the SAB CAAC for the upcoming review of the draft benzo[a]pyrene assessment. (epa.gov)
  • EPA transmitted the external peer review draft benzo[a]pyrene assessment, including responses to major public comments, and the draft charge to the peer reviewers to the SAB. (epa.gov)
  • In May 2017 the CORESTA Tobacco and Tobacco Products Analytes Sub-Group (TTPA SG) initiated a collaborative study for the determination of ammonia and benzo[a]pyrene in smokeless tobacco, cigarette filler, and ground cigars (wrapper, binder, and filler). (coresta.org)
  • Similarly, benzo(b)fluoranthene demonstrates carcinogenicity in laboratory assays, but benzo(k)fluoranthene does not. (jrank.org)
  • Benzo(a)pyrene and other polycyclic aromatic compounds are among the diverse products of the incomplete oxidation of organic fuels, such as coal , oil, wood , and organic wastes. (jrank.org)
  • These experimental results indicated that the synthesized deep-cavity calixarene materials could be used to selectively remove benzo[a]pyrene and major phenolic compounds in MCS. (coresta.org)
  • Anti-inflammatory and apoptotic signalling effect of fucoxanthin on benzo(A)pyrene-induced lung cancer. (greenmedinfo.com)
  • Fisetin modulates mitochondrial enzymes and apoptotic signals in benzo(a)pyrene-induced lung cancer. (nih.gov)
  • NHE-1 relocation outside cholesterol-rich membrane microdomains is associated with its benzo[a]pyrene-related apoptotic function. (inserm.fr)
  • Experiments with strains of mice engineered to remove (knockout) CYP1A1 and CYP1B1 reveal that CYP1A1 primarily acts to protect mammals from low doses of benzopyrene, and that removing this protection causes the biological accumulation of large concentrations of benzopyrene. (primidi.com)
  • In complementary experiments, sulforaphane blocked benzo[ a ]pyrene-evoked forestomach tumors in ICR mice. (pnas.org)
  • Benzyl isothiocyanate (BITC) inhibits lung tumorigenesis induced in A/J mice by benzo[a]pyrene (B[a]P). In contrast, phenethyl isothiocyanate (PEITC) does not. (eurekamag.com)
  • Turmeric and/or its main coloring component, curcumin (diferuloylmethane), have been shown to inhibit benzo( a ) pyrene [B( a )P]-induced forestomach papillomas in mice. (begellhouse.com)
  • We explored the effects of intermittent normobaric hyperoxia alone or combined with chemotherapy on the growth, general morphology, oxidative stress, and apoptosis of benzo[a]pyrene (B[a]P)-induced lung tumors in mice. (kjim.org)
  • Man-made releases of benzo(a)pyrene are to the air, where sunlight turns the chemical into a dry form that falls to the ground and breaks down in the soil. (burningissues.org)
  • Contact with benzo(a)pyrene in the air, water, or soil near a waste site, or another polluted site. (burningissues.org)
  • For references , please go to https://www.eea.europa.eu/data-and-maps/figures/concentration-of-benzo-a-pyrene-bap-in-the-upper-soil-in-kindergartens-in-the-czech-cities-monitored-in-2004 or scan the QR code. (europa.eu)
  • Development and application of a skin cancer slope factor for exposures to benzo[a]pyrene in soil. (semanticscholar.org)
  • Benzo[a]pyrene is a potent carcinogen and mutagen present in cigarette smoke, automotive exhaust, burnt wood fumes, barbecued and smoked meat etc. (news-medical.net)
  • In experiments performed with regular lung cells - more precisely bronchial epithelial cells - cultures were exposed to 0.5 and 1 micromolar (μM) benzo[a]pyrene for seven days. (news-medical.net)
  • Benzopyrene , found in tobacco smoke (including cigarette smoke), was shown to cause genetic damage in lung cells that was identical to the damage observed in the DNA of most malignant lung tumours. (primidi.com)
  • The present study was aimed to delineate in vivo mechanisms of orally administered fisetin with special reference to mitochondrial dysfunction in lung tissues employing benzo(a)pyrene (B(a)P) as the model lung carcinogen. (nih.gov)
  • Statistical eliminative process shows 3:4- benzopyrene (BP) to be the hydrocarbon of prime importance in lung cancer and bronchitis, with 1:12 benzoperylene contributing. (worldwidescience.org)
  • Previous studies showed that dietary calcium D-glucarate (CG) inhibited benzo[a]pyrene (B[a]P)-induced A/J mouse lung tumorigenesis, suppressing cell proliferation and chronic inflammation and inducing apoptosis during late post-initiation stages. (spandidos-publications.com)
  • Fucoxanthin role in chemoprevention of lung cancer in mouse model induced using benzo(a)pyrene [B(a)P] has been presented here. (begellhouse.com)
  • Activity of rat UGT1A1 towards benzo[a]pyrene phenols and dihydrodiols. (biomedsearch.com)
  • Four UDP-glucuronosyltransferases from the rat UGT1A family were tested for activity towards benzo[a]pyrene phenols and dihydrodiols. (biomedsearch.com)
  • When foreskin was cultured for 16 hours in the presence of 10 micromolar benz[α]anthracene, a two- to fivefold increase in activity of benzo[α]pyrene hydroxylase was obtained. (sciencemag.org)
  • I. J. Sadowski, J. A. Wright and L. G. Israels, A permeabilized cell system for studying regulation of aryl hydrocarbon hydroxylase: NADPH as rate limiting factor in benzo(a)pyrene metabolism, Int. J. Biochem. (springer.com)
  • Benzopyrene was found to be behind the link , since it induces vitamin A deficiency in rats. (primidi.com)
  • Effect of dihydromyricetin on benzo[a]pyrene activation in rats. (nel.edu)
  • You can also breathe benzo(a)pyrene from cigarette smoke, wood smoke, vehicle exhaust, asphalt roads or smoke from burning farm plants. (burningissues.org)
  • Land developers and remediators in Pennsylvania and New Jersey may soon have an easier time addressing soils containing benzo[a]pyrene, one of the most ubiquitous urban contaminants, thanks to updated information that was just released by U.S. Environmental Protection Agency (EPA). (lexology.com)
  • We previously reported that overexpression of catalase upregulated xenobiotic- metabolizing enzyme (XME) expression and diminished benzo(a)pyrene (BaP) intermediate accumulation in mouse aortic endothelial cells (MAECs). (sigmaaldrich.com)
  • Foreskins from children who were circumcised 2 to 4 days after birth contain an enzyme system that hydroxylates the carcinogen benzo[α]pyrene. (sciencemag.org)
  • beta-Glucuronidase catalyzes the hydrolysis of benzo[a]pyrene-3-glucuronide to 3-hydroxybenzo[a]pyrene. (sciencemag.org)
  • During the enzymatic hydrolysis, a benzo[a]pyrene derivative is formed which binds to DNA to a far greater extent than either the 3-hydroxybenzo[a]pyrene or its glucuronide. (sciencemag.org)
  • Antineoplaston A10 has a chempreventive effect on benzo(a)pyrene-induced pulmonary neoplasia. (greenmedinfo.com)
  • Animals in group A and group B were given 3,4- benzopyrene -corn oil mixture pulmonary injection fortnightly for 4 times, while in group C corn oil only. (worldwidescience.org)
  • Since this flavonoid is being considered for human use, the in vivo study of DHM interactions with the cytochrome P450 (CYP) multienzyme system in the respect of metabolic activation of a model food-born carcinogen, benzo[a]pyrene (BaP), is of high importance. (nel.edu)
  • Peroxyl radical- and cytochrome P-450-dependent metabolic activation of (+)-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene in mouse skin in vitro and in vivo. (semanticscholar.org)
  • Benzo(a)pyrene inhibits epidermal growth factor binding and receptor autophosphorylation in human placental cell cultures. (aspetjournals.org)
  • The legal limit for benzo[a]pyrene, established in 1992, was based on analytical detection limits at the time that the standard was set. (ewg.org)
  • One such compound, benzo(a)pyrene (BaP), leads to covalent DNA modifications and the deregulation of gene expression. (worldwidescience.org)
  • Lin, T. and Yang, M.S. (2007) Benzo [a] pyrene-induced elevation of GSH level protects against oxidative stress and enhances xenobiotic detoxification in human HepG2 cells. (scirp.org)
  • The compound is one of the benzopyrenes , formed by a benzene ring fused to pyrene , and is the result of incomplete combustion at temperatures between 300 °C (572 °F) and 600 °C (1,112 °F). (wikipedia.org)
  • Binding of benzo(a)pyrene to hepatic cytosolic protein enhances its microsomal oxidation. (cdc.gov)
  • Evidence was presented to indicate that the binding of benzo(a)pyrene (50328) (BaP) to a protein in rat liver cytosol facilitates its oxidation by microsomal enzymes. (cdc.gov)
  • 6-gingerol delays tumorigenesis in benzo[a]pyrene and dextran sulphate sodium-induced colorectal cancer. (greenmedinfo.com)
  • Animal studies have shown that dietary intake of benzo(a)pyrene (BaP), a PAH, causes increased levels of tumors at several sites, particularly in the gastrointestinal tract ( 11 ). (aacrjournals.org)
  • The distribution of radioactive material within maternal and embryonic/fetal mouse tissue was studied over a period of 2 days following a single dose of 14C-benzo(a)pyrene (B(a)P) orally on days 11, 12, 13 or 18 of pregnancy. (nih.gov)
  • The CEE and benzo[a]pyrene were administered orally for a week, on a daily basis. (mdpi.com)
  • Benzo[a]pyrene is a polynuclear aromatic hydrocarbon (PAH) and is found as the result of the combustion of organic matter such as wood, coal, oil, gasoline, diesel fuel, kerosene, and charcoal. (lexology.com)
  • F. Feo, L. Pirisi, R. Pascale, L. Daino, S. Frassetto, S. Zanetti and R. Garcea, Modulatory mechanisms of chemical carcinogenesis: the role of the NADPH pool in benzo(a)pyrene activation, Toxicol. (springer.com)
  • De Buck SS, Bouche FB, Brandenburger A, Muller CP: Modulation of the metabolism and adverse effects of benzo[a]pyrene by a specific antibody: a novel host factor in environmental carcinogenesis? (exbio.cz)
  • Scharnweber T, Fisher M, Suchanek M, Knopp D, Niessner R: Monoclonal antibody to polycyclic aromatic hydrocarbons based on a new benzo[a]pyrene immunogen. (exbio.cz)
  • Transformation rates of naphthalene, phenanthrene, and benzo[ a ]pyrene in oxidized surficial sediments of a polluted urban estuary, Boston Harbor, Mass., were determined over a period of 15 months. (asm.org)
  • phenanthrene, 7.9 to 19.8 days, and benzo[ a ]pyrene, 53.7 to 82.3 days. (asm.org)
  • In this study, a new complementary DNA (cDNA) of the CYP1B subfamily encoding 1B1 was isolated from Nile tilapia ( Oreochromis niloticus ) liver after intracoelomic injection with benzo (a) pyrene (BaP). (ajol.info)
  • To evaluate the inhibitory effects of PEITC against benzo[a]pyreneinducedrise in rat liver CYP1A1 mRNA and apoprotein levels. (waocp.org)
  • Studies investigated the effects of benzo(a)pyrene (BP) treatment on epidermal growth factor (EGF) receptor binding and kinase activity in human placental cell cultures. (aspetjournals.org)
  • Details and Download Full Text PDF: Effects of mustard sprouts and allylisothiocyanate on benzo(a)pyrene-induced DNA damage in human-derived cells: a model study with the single cell gel electrophoresis/Hep G2 assay. (pubfacts.com)
  • The aim of this study was to investigate the chemoprotective effects of mustard sprouts on benzo(a)pyrene [B(a)P]-induced DNA damage in the single cell gel electrophoresis (SCGE)/Hep G2 assay. (pubfacts.com)
  • Effects of garden and water cress juices and their constituents, benzyl and phenethyl isothiocyanates, towards benzo(a)pyrene-induced DNA damage: a model study with the single cell gel electrophoresis/Hep G2 assay. (pubfacts.com)
  • The objective of this study was to determine whether sediment ingestion or water ventilation was the primary route of uptake for benzo[ a ]pyrene (B a P) in the gizzard shad ( Dorosoma cepedianum ), a detritivorous fish. (usgs.gov)
  • ALS Environmental may or may not test for Benzo(a)pyrene (CAS # 50-32-8). (caslab.com)