Compounds with a BENZENE fused to IMIDAZOLES.
Agents destructive to parasitic worms. They are used therapeutically in the treatment of HELMINTHIASIS in man and animal.
A benzimidazole that acts by interfering with CARBOHYDRATE METABOLISM and inhibiting polymerization of MICROTUBULES.
Substances used in the treatment or control of nematode infestations. They are used also in veterinary practice.
A benzimidazole broad-spectrum anthelmintic structurally related to MEBENDAZOLE that is effective against many diseases. (From Martindale, The Extra Pharmacopoeia, 30th ed, p38)
A genus of very small TAPEWORMS, in the family Taeniidae. The adult form is found in various CARNIVORA but not humans. The larval form is seen in humans under certain epidemiologic circumstances.
Organic compounds that have the general formula R-SO-R. They are obtained by oxidation of mercaptans (analogous to the ketones). (From Hackh's Chemical Dictionary, 4th ed)
Substances that are destructive to protozoans.
A genus of flagellate intestinal EUKARYOTES parasitic in various vertebrates, including humans. Characteristics include the presence of four pairs of flagella arising from a complicated system of axonemes and cysts that are ellipsoidal to ovoidal in shape.
Compounds that contain benzimidazole joined to a 2-methylpyridine via a sulfoxide linkage. Several of the compounds in this class are ANTI-ULCER AGENTS that act by inhibiting the POTASSIUM HYDROGEN ATPASE found in the PROTON PUMP of GASTRIC PARIETAL CELLS.
A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.
A microtubule subunit protein found in large quantities in mammalian brain. It has also been isolated from SPERM FLAGELLUM; CILIA; and other sources. Structurally, the protein is a dimer with a molecular weight of approximately 120,000 and a sedimentation coefficient of 5.8S. It binds to COLCHICINE; VINCRISTINE; and VINBLASTINE.
Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.

Blocking angiotensin II ameliorates proteinuria and glomerular lesions in progressive mesangioproliferative glomerulonephritis. (1/3157)

BACKGROUND: The renin-angiotensin system is thought to be involved in the progression of glomerulonephritis (GN) into end-stage renal failure (ESRF) because of the observed renoprotective effects of angiotensin-converting enzyme inhibitors (ACEIs). However, ACEIs have pharmacological effects other than ACE inhibition that may help lower blood pressure and preserve glomerular structure. We previously reported a new animal model of progressive glomerulosclerosis induced by a single intravenous injection of an anti-Thy-1 monoclonal antibody, MoAb 1-22-3, in uninephrectomized rats. Using this new model of progressive GN, we examined the hypothesis that ACEIs prevent the progression to ESRF by modulating the effects of angiotensin II (Ang II) on the production of transforming growth factor-beta (TGF-beta) and extracellular matrix components. METHODS: We studied the effect of an ACEI (cilazapril) and an Ang II type 1 receptor antagonist (candesartan) on the clinical features and morphological lesions in the rat model previously reported. After 10 weeks of treatment with equihypotensive doses of cilazapril, cilazapril plus Hoe 140 (a bradykinin receptor B2 antagonist), candesartan, and hydralazine, we examined systolic blood pressure, urinary protein excretion, creatinine clearance, the glomerulosclerosis index, and the tubulointerstitial lesion index. We performed a semiquantitative evaluation of glomerular immunostaining for TGF-beta and collagen types I and III by immunofluorescence study and of these cortical mRNA levels by Northern blot analysis. RESULTS: Untreated rats developed massive proteinuria, renal dysfunction, and severe glomerular and tubulointerstitial injury, whereas uninephrectomized control rats did not. There was a significant increase in the levels of glomerular protein and cortical mRNA for TGF-beta and collagen types I and III in untreated rats. Cilazapril and candesartan prevented massive proteinuria, increased creatinine clearance, and ameliorated glomerular and tubulointerstitial injury. These drugs also reduced levels of glomerular protein and cortical mRNA for TGF-beta and collagen types I and III. Hoe 140 failed to blunt the renoprotective effect of cilazapril. Hydralazine did not exhibit a renoprotective effect. CONCLUSION: These results indicate that ACEIs prevent the progression to ESRF by modulating the effects of Ang II via Ang II type 1 receptor on the production of TGF-beta and collagen types I and III, as well as on intrarenal hemodynamics, but not by either increasing bradykinin activity or reducing blood pressure in this rat model of mesangial proliferative GN.  (+info)

Mibefradil (Ro 40-5967) inhibits several Ca2+ and K+ currents in human fusion-competent myoblasts. (2/3157)

1. The effect of mibefradil (Ro 40-5967), an inhibitor of T-type Ca2+ current (I(Ca)(T)), on myoblast fusion and on several voltage-gated currents expressed by fusion-competent myoblasts was examined. 2. At a concentration of 5 microM, mibefradil decreases myoblast fusion by 57%. At this concentration, the peak amplitudes of I(Ca)(T) and L-type Ca2+ current (I(Ca)(L)) measured in fusion-competent myoblasts are reduced by 95 and 80%, respectively. The IC50 of mibefradil for I(Ca)(T) and I(Ca)(L) are 0.7 and 2 microM, respectively. 3. At low concentrations, mibefradil increased the amplitude of I(Ca)(L) with respect to control. 4. Mibefradil blocked three voltage-gated K+ currents expressed by human fusion-competent myoblasts: a delayed rectifier K+ current, an ether-a-go-go K+ current, and an inward rectifier K+ current, with a respective IC50 of 0.3, 0.7 and 5.6 microM. 5. It is concluded that mibefradil can interfere with myoblast fusion, a mechanism fundamental to muscle growth and repair, and that the interpretation of the effect of mibefradil in a given system should take into account the action of this drug on ionic currents other than Ca2+ currents.  (+info)

Binding of Cob(II)alamin to the adenosylcobalamin-dependent ribonucleotide reductase from Lactobacillus leichmannii. Identification of dimethylbenzimidazole as the axial ligand. (3/3157)

The ribonucleoside triphosphate reductase (RTPR) from Lactobacillus leichmannii catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates and uses coenzyme B12, adenosylcobalamin (AdoCbl), as a cofactor. Use of a mechanism-based inhibitor, 2'-deoxy-2'-methylenecytidine 5'-triphosphate, and isotopically labeled RTPR and AdoCbl in conjunction with EPR spectroscopy has allowed identification of the lower axial ligand of cob(II)alamin when bound to RTPR. In common with the AdoCbl-dependent enzymes catalyzing irreversible heteroatom migrations and in contrast to the enzymes catalyzing reversible carbon skeleton rearrangements, the dimethylbenzimidazole moiety of the cofactor is not displaced by a protein histidine upon binding to RTPR.  (+info)

Resetting of exaggerated tubuloglomerular feedback activity in acutely volume-expanded young SHR. (4/3157)

One purpose of the present study was to evaluate the ability of 7-wk-old spontaneously hypertensive rats (SHR) to reset tubuloglomerular feedback (TGF) activity in response to acute volume expansion (VE). Second, we evaluated the contribution of ANG II, via its action on AT1 receptors, to TGF control of glomerular function during VE. TGF was assessed by micropuncture methods and proximal tubular stop-flow pressure (SFP) determinations in SHR, Wistar-Kyoto rats (WKY), and Sprague-Dawley rats (SD). During euvolemia SHR exhibited enhanced TGF activity. In the same animals acute VE was achieved by infusion of saline (5 ml. h-1. 100 g body wt-1). VE led to resetting of TGF in all three strains. Maximal SFP responses, elicited by a 30-40 nl/min loop of Henle perfusion rate, decreased from 19 to 12 mmHg in SHR and, on average, from 11 to 5 mmHg in WKY and SD (P < 0.001). Tubular flow rate producing a half-maximal response (turning point) shifted to higher flow rates during VE, from 12 to 14 nl/min in SHR and from 15 to 19 nl/min in WKY. Administration of the AT1 receptor blocker candesartan (0.05 mg/kg iv) during sustained VE decreased TGF-mediated reductions in SFP in SHR and slightly increased the turning point in WKY. Nevertheless, other parameters of TGF activity were unaffected by AT1 receptor blockade. In conclusion, young SHR possess the ability to reset TGF activity in response to VE to a degree similar to compensatory adjustments in WKY. However, TGF remains enhanced in SHR during VE. ANG II and its action on AT1 receptors are in part responsible for the exaggerated SFP responses in young SHR during VE.  (+info)

Effect of 5-HT4 receptor stimulation on the pacemaker current I(f) in human isolated atrial myocytes. (5/3157)

OBJECTIVE: 5-HT4 receptors are present in human atrial cells and their stimulation has been implicated in the genesis of atrial arrhythmias including atrial fibrillation. An I(f)-like current has been recorded in human atrial myocytes, where it is modulated by beta-adrenergic stimulation. In the present study, we investigated the effect of serotonin (5-hydroxytryptamine, 5-HT) on I(f) electrophysiological properties, in order to get an insight into the possible contribution of I(f) to the arrhythmogenic action of 5-HT in human atria. METHODS: Human atrial myocytes were isolated by enzymatic digestion from samples of atrial appendage of patients undergoing coeffective cardiac surgery. Patch-clamped cells were superfused with a modified Tyrode's solution in order to amplify I(f) and reduce overlapping currents. RESULTS AND CONCLUSIONS: A time-dependent, cesium-sensitive increasing inward current, that we had previously described having the electrophysiological properties of the pacemaker current I(f), was elicited by negative steps (-60 to -130 mV) from a holding potential of -40 mV. Boltzmann fit of control activation curves gave a midpoint (V1/2) of -88.9 +/- 2.6 mV (n = 14). 5-HT (1 microM) consistently caused a positive shift of V1/2 of 11.0 +/- 2.0 mV (n = 8, p < 0.001) of the activation curve toward less negative potentials, thus increasing the amount of current activated by clamp steps near the physiological maximum diastolic potential of these cells. The effect was dose-dependent, the EC50 being 0.14 microM. Maximum current amplitude was not changed by 5-HT. 5-HT did not increase I(f) amplitude when the current was maximally activated by cAMP perfused into the cell. The selective 5-HT4 antagonists, DAU 6285 (10 microM) and GR 125487 (1 microM), completely prevented the effect of 5-HT on I(f). The shift of V1/2 caused by 1 microM 5-HT in the presence of DAU 6285 or GR 125487 was 0.3 +/- 1 mV (n = 6) and 1.0 +/- 0.6 mV (n = 5), respectively (p < 0.01 versus 5-HT alone). The effect of 5-HT4 receptor blockade was specific, since neither DAU 6285 nor GR 125487 prevented the effect of 1 microM isoprenaline on I(f). Thus, 5-HT4 stimulation increases I(f) in human atrial myocytes; this effect may contribute to the arrhythmogenic action of 5-HT in human atrium.  (+info)

Differential effects of pinacidil, cromakalim, and NS 1619 on electrically evoked contractions in rat vas deferens. (6/3157)

AIM: To compare the inhibitory action of electrically evoked contractions of rat epididymal vas deferens by pinacidil (Pin), cromakalim (Cro), and NS 1619. METHODS: Monophasic contractions were evoked by electric field stimulation in rat isolated epididymal half of vas deferens. RESULTS: Newly developed ATP-sensitive K+ channel openers, Pin and Cro, concentration-dependently reduced the electrically evoked (0.3 Hz, 1 ms pulse duration, 60 V) contractions and glibenclamide but not charybdotoxin antagonized the inhibitory effects of both agents. Pin shifted the concentration-response curve for norepinephrine to the right with reducing the magnitude of the maximum contraction in a glibenclamide-sensitive fashion. The large-conductance Ca(2+)-activated K+ channel opener, NS 1619, inhibited the electrically evoked contractions in a concentration-dependent manner. Charybdotoxin (100 nmol.L-1) partially reduced the effect of NS 1619 but glibenclamide (10 mumol.L-1) showed no effect. None of these 3 agents affected the basal tension. CONCLUSION: Both ATP-sensitive and Ca(2+)-activated K+ channels presented in vas deferens smooth muscles involved in regulation of muscle contractility.  (+info)

Development of nuclear transfer and parthenogenetic rabbit embryos activated with inositol 1,4,5-trisphosphate. (7/3157)

The present study was carried out to evaluate the effects of different activation protocols, enucleation methods, and culture media on the development of parthenogenetic and nuclear transfer (NT) rabbit embryos. Electroporation of 25 mM inositol 1,4, 5-trisphosphate (IP3) in calcium- and magnesium-free PBS immediately induced a single intracellular calcium transient in 6 out of 14 metaphase II-stage rabbit oocytes evaluated during a 10-min recording period. The percentage of oocytes treated with IP3 followed by 6-dimethylaminopurine (IP3 + DMAP) that cleaved (83.9%) and reached the blastocyst stage (50%) was significantly higher (p < 0.05) than those activated with multiple pulses (61.6% and 30.1%, respectively) or treated with ionomycin + DMAP (52.9% and 5.7%, respectively). Development of IP3 + DMAP-activated rabbit oocytes and in vivo-fertilized zygotes in different culture media was studied. Development of activated oocytes to the blastocyst stage in Earle's balanced salt solution (EBSS) supplemented with MEM nonessential amino acids, basal medium Eagle amino acids, 1 mM L-glutamine, 0.4 mM sodium pyruvate, and 10% fetal bovine serum (FBS) (EBSS-complete) (40.6%) was significantly higher (p < 0.05) than those that developed in either Dulbecco's Modified Eagle's medium (DMEM)/RPMI + 10% FBS (15.5%) or CR1aa + 10% FBS (4%) medium. In addition, 100% of in vivo-fertilized rabbit zygotes developed to the blastocyst stage in EBSS-complete. A third set of experiments was carried out to study the efficiency of blind versus stained (Hoechst 33342) enucleation of oocytes. Twenty-nine of 48 blind enucleated and IP3 + DMAP-activated oocytes cleaved (60.4%), and 15 (31.2%) subsequently reached the blastocyst stage, whereas 9 of 52 oocytes enucleated using epifluorescence (17.3%) cleaved, and none of these reached the blastocyst stage. When the above parameters that yielded the highest blastocysts were combined in an NT experiment using adult rabbit fibroblast nuclei, 72.2% (39 of 54) of the fused nuclear transplant embryos cleaved and 29.6% (16 of 54) reached the blastocyst stage.  (+info)

Serial changes in sarcoplasmic reticulum gene expression in volume-overloaded cardiac hypertrophy in the rat: effect of an angiotensin II receptor antagonist. (8/3157)

This study was designed to clarify whether gene expression in the cardiac sarcoplasmic reticulum [sarcoplasmic reticulum Ca2+-ATPase (SERCA), phospholamban, ryanodine receptor and calsequestrin] changes in accordance with left ventricular functional alterations in the volume-overloaded heart. Further, the effect of the angiotensin II type 1 receptor antagonist, TCV-116, on the expression of these genes was also evaluated. Left ventricular fractional shortening was significantly increased at 7 days, had returned to control levels at 21 days, and had significantly decreased at 35 days after the shunt operation, compared with sham-operated rats. The level of SERCA mRNA was significantly decreased at both 21 days and 35 days after the shunt operation. The levels of ryanodine receptor and phospholamban mRNAs were significantly decreased at 35 days in shunt-operated rats. The decrease in the SERCA mRNA level preceded the development of cardiac dysfunction. The levels of SERCA and ryanodine receptor mRNAs were correlated positively with left ventricular fractional shortening (r=0.73, P<0.0001 and r=0.61, P<0.01 respectively). Attenuation of the decrease in left ventricular fractional shortening occurred on treatment with TCV-116. After the treatment with TCV-116, the levels of SERCA and phospholamban mRNAs were restored to the respective values in sham-operated rats. Ryanodine receptor mRNA levels remained unchanged after treatment with TCV-116. These results indicate that the down-regulation of SERCA and ryanodine receptor mRNA levels may be related to cardiac dysfunction in the volume-overloaded heart. In addition, treatment with an angiotensin II receptor antagonist may restore the altered sarcoplasmic reticulum mRNA levels to control levels, and this may result in attenuation of the functional impairment in the volume-overloaded heart.  (+info)

... as well as the benzimidazole opioids such as etonitazene. Benzimidazole derivatives are among the top frequently used ring ... and tenatoprazole all contain a benzimidazole group. Other pharmaceutical drugs which contain a benzimidazole group include ... Benzimidazole is a base: C6H4N(NH)CH + H+ → [C6H4(NH)2CH]+ It can also be deprotonated with stronger bases: C6H4N(NH)CH + LiH ... Benzimidazole is a heterocyclic aromatic organic compound. This bicyclic compound may be viewed as fused rings of the aromatic ...
The solubility of benzimidazole fungicides is low at physiological pH and becomes high at low pH. In plants, carbendazim, ... Benzimidazole fungicides are a class of fungicides including benomyl, carbendazim (MBC), thiophanate-methyl, thiabendazole and ... Mutant pathogens resistant to one benzimidazole fungicide are usually resistant to all of them. The F200Y and E198A,G,K ... Because of resistance problems, use of benzimidazole fungicides has declined. They are suspected to be toxic to animals, ...
Synthese neuer 2-Amino-benzimidazole" [Benzimidazole Derivatives and related Heterocycles VII. Synthesis of new 2-amino- ... Gross F, Turrian H (October 1957). "[Benzimidazole derivatives with strong analgesic effects]" [Benzimidazole derivatives with ... Benzimidazole opioids, also known as nitazenes, are a class of synthetic opioids with an unusual structure and often referred ... Like other synthetic opioids, benzimidazole opioids bind the mu-opioid receptor and may exhibit potency up to several hundred ...
It is a member of the benzimidazole family of anthelmintics. The benzimidazole drugs share a common molecular structure, ... Benzimidazoles such as triclabendazole are generally accepted to bind to beta-tubulin therefore preventing the polymerization ... It is a member of the benzimidazole family of medications for worms. Triclabendazole was approved for medical use in the United ... Wolfe, M. Michael; Lowe, Robert C. (2014). "Benzimidazoles". Pocket Guide to GastrointestinaI Drugs. John Wiley & Sons. p. ...
All but one benzimidazole product must be administered orally which has led to their reduction in use as pour-on drenches are ... Macrocyclic lactones and benzimidazoles in the form of pour on solutions are the most commonly used drench formula, however ... "Benzimidazoles - Pharmacology". Veterinary Manual. Retrieved 2019-05-21. Berger, H.; Garces, T. R.; Wang, G. T.; Gale, G. O.; ... Benzimidazoles are another chemical family which is effective in the eradication of some parasite infections with particular ...
Most benzimidazoles are effective. Mebendazole, triclabendazole and fenbendazole are commonly used. Ivermectin and pyrantel ...
... and other benzimidazole antithelmetics are active against both larval and adult stages of nematodes, and in the ... Mebendazole is a broad-spectrum antihelminthic agent of the benzimidazole type. Mebendazole came into use in 1971, after it was ... Lacey E (April 1990). "Mode of action of benzimidazoles". Parasitology Today. 6 (4): 112-5. doi:10.1016/0169-4758(90)90227-U. ... Benzimidazoles, Carbamates, Embryotoxicants, Johnson & Johnson brands, Janssen Pharmaceutica, Wikipedia medicine articles ready ...
P. N. Preston (1980). Benzimidazoles and congeneric tricyclic compounds. John Wiley and Sons. pp. 475-. ISBN 978-0-471-08189-0 ...
There are several benzimidazoles were successful in clearing infection, including albendazole, febantel, fenbendazole, ... Broad spectrum anthelmintics include benzimidazoles (BZs). BZs have been used since the 1960s, and resistance was detected in ... Infections are usually treated with broad-spectrum anthelmintics such as benzimidazole, but resistance to these drugs has ... Resistance has been reported to all broad spectrum anthelmintics, which are benzimidazoles (BZs), levamisole/morantel (LEV) and ...
Verbist BM, De Cleyn MA, Surkyn M, Fraiponts E, Aerssens J, Nijsen MJ, Gijsen HJ (April 2008). "5-Sulfonyl-benzimidazoles as ... WO patent 2004/108688, LIU Z, PAGÈ D, WALPOLE C, YANG H, "BENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM, PREPARATION ... Many related benzimidazole-derived cannabinoid ligands are known. AM-6545 AZD-1940 CB-13 RQ-00202730 Yu XH, Cao CQ, Martino G, ... "Novel benzimidazole derivatives as selective CB2 agonists". Bioorganic & Medicinal Chemistry Letters. 18 (13): 3695-700. doi: ...
Synthese neuer 2-Amino-benzimidazole" [Benzimidazole Derivatives and related Heterocycles VII. Synthesis of new 2-amino- ... Gross F, Turrian H (October 1957). "[Benzimidazole derivatives with strong analgesic effects]" [Benzimidazole derivatives with ... The benzimidazole is then alkylated with the desired 1-chloro-2-dialkylaminoethane, forming the final product. This particular ... Hunger A, Kebrle J, Rossi A, Hoffmann K (October 1957). "[Synthesis of analgesically active benzimidazole derivatives with ...
2-(4'-Thiazolyl)-Benzimidazole, A New Anthelmintic". Journal of the American Chemical Society. 83 (7): 1764-1765. doi:10.1021/ ... Setzinger, Meyer; Painfield, North; Gaines, Water A.; Grenda, Victor J. (1965). "Novel Preparation of Benzimidazoles from N- ... 5-isopropoxycarbonylamino-benzimidazole". Experientia. 26 (5): 550-551. doi:10.1007/BF01898506. PMID 4245814. S2CID 26567527. ...
Grimmett, M. R. (1997). Imidazole and Benzimidazole Synthesis. Academic Press. pp. 71ff. ISBN 9780080534459. (Articles without ...
Benzimidazole fungicides are used. Benzimidazole resistance has occurred. Chen, Q.; Jiang, J.R.; Zhang, G.Z.; Cai, L.; Crous, P ... doi:10.1046/j.1365-3059.2002.00727.x. van de Graaf, P. (2003). "Aspects of the Biology and Control of Benzimidazole Resistant ...
See also § Honeybees.) Benzimidazole is commonly used against Monilinia fructicola and M. laxa. The Ma & Michaelides group has ... See § Stonefruit and § Benzimidazole.) Botryosphaeria dothidea is a significant fungal diseases here which often receives ... For common fungal diseases see § Monilinia fructicola, § Monilinia laxa, and for the fungicide see § Benzimidazole. UCD's FPS ... laxa are significant diseases of stonefruits here and benzimidazole is often used. The Ma & Michaelides group has done ...
Benzimidazoles substituted with an alkylamine at position 2 have a venerable history as H1 antihistaminic agents. The standard ... Imide formation with the remaining free amino group closes the ring to afford 2-chloromethyl benzimidazole (3). Displacement of ... "Zur Darstellung der Benzimidazole". Justus Liebigs Annalen der Chemie. 575 (2): 162-173. doi:10.1002/jlac.19525750204. GB ... Benzimidazoles, Chloroarenes, H1 receptor antagonists, Pyrrolidines, All stub articles, Respiratory system drug stubs). ...
ISBN 978-0-08-042072-1. Grimmett, M. Ross (1997). Imidazole and Benzimidazole Synthesis. Academic Press. ISBN 978-0-08-053445-9 ... Benzimidazole, an analog with a fused benzene ring Dihydroimidazole or imidazoline, an analog where the 4,5-double bond is ...
Classic PNMT inhibitors include benzimidazoles, quinolones, and purines. Inhibition can also be produced by the addition of S- ...
However, benzimidazoles are very weak as a vermicide. As with other trematodes, praziquantel is the drug of choice. Lately, ...
Optimization of substituted benzimidazoles and their antisecretory effects were studied on the newly discovered proton pump to ... It is similar to lansoprazole in having no substituents on its benzimidazole part and a methyl group at site 3 on the pyridine ... Addition of a trifluoromethyl group to the benzimidazole moiety led to a series of very active compounds with varying solution- ... It has a difluoroalkoxy sidegroup on the benzimidazole part and two methoxy groups in position 3 and 4 on the pyridine. ...
Currently, benzimidazoles (such as albendazole) are used to treat AE: only halt their proliferation and do not actually kill ... Jura H, Bader A, Frosch M (May 1998). "In vitro activities of benzimidazoles against Echinococcus multilocularis metacestodes ... best results in reducing parasite burden Despite the improvements in the chemotherapy of echinococcosis with benzimidazole ...
Piperazine salts, levamisole, and benzimidazoles are all reported treatments. Ascarid eggs are resistant to desiccation, ...
Hunger A, Kebrle J, Rossi A, Hoffmann K (October 1957). "[Synthesis of analgesically active benzimidazole derivatives with ... Etonitazene and Related Benzimidazoles". ACS Chemical Neuroscience. 12 (7): 1072-1092. doi:10.1021/acschemneuro.1c00037. PMID ... "Acute intoxications and fatalities associated with benzimidazole opioid (nitazene analog) use: A systematic review". ...
Etonitazene and Related Benzimidazoles". ACS Chemical Neuroscience. 12 (7): 1072-1092. doi:10.1021/acschemneuro.1c00037. PMID ...
Synthese neuer 2-Amino-benzimidazole" [Benzimidazole Derivatives and related Heterocycles VII. Synthesis of new 2-amino- ... Gross F, Turrian H (October 1957). "[Benzimidazole derivatives with strong analgesic effects]" [Benzimidazole derivatives with ... Side effects of benzimidazole derived opioids are likely to be similar to those of fentanyl, which include itching, nausea and ... Isotonitazene is a benzimidazole derived opioid analgesic drug related to etonitazene, which has been sold as a designer drug. ...
Jura, Heike; Bader, Augustinus; Frosch, Matthias (1998). "In Vitro Activities of Benzimidazoles against Echinococcus ...
... (Desnitroetonitazene, Etazen, Etazene, Etazone) is a benzimidazole derived opioid analgesic drug, which was ... Brorphine Etonitazepyne Isotonitazene Metonitazene Metodesnitazene MCHB-1 List of benzimidazole opioids Ujváry, István; ... a novel benzimidazole opioid NPS identified in seized material: crystal structure and spectroscopic characterization". Forensic ... a novel benzimidazole opioid NPS identified in seized material: crystal structure and spectroscopic characterization". Forensic ...
It comes under the chemical class of the benzimidazoles. This drug is barely used in horses, goats, sheep, and cattle. It is ... Oxfendazole is a broad spectrum benzimidazole anthelmintic. Its main use is for protecting livestock against roundworm, ...
... (also known as Metazene) is a benzimidazole derivative with opioid effects, though unlike related compounds ... Etonitazepyne Isotonitazene List of benzimidazole opioids Hunger A, Kebrle J, Rossi A, Hoffmann K (1960). "Benzimidazol‐ ... Etonitazene and Related Benzimidazoles". ACS Chemical Neuroscience. 12 (7): 1072-1092. doi:10.1021/acschemneuro.1c00037. PMID ... Benzimidazoles, Aromatic ethers, All stub articles, Analgesic stubs). ...
Reactions with carboxylic acids and their derivatives afford benzimidazoles. The herbicides benomyl and fuberidazole are made ...
Benzimidazole anthelmintic drugs. Class Summary. Benzimidazoles have efficacy on E granulosus and E multilocularis larval ... Benzimidazoles for the treatment of cystic and alveolar echinococcosis: what is the consensus?. Expert Rev Anti Infect Ther. ... Prediction of benzimidazole therapy duration with PET/CT in inoperable patients with alveolar echinococcosis. Sci Rep. 2022 Jul ... Reuter S, Jensen B, Buttenschoen K, Kratzer W, Kern P. Benzimidazoles in the treatment of alveolar echinococcosis: a ...
Herein, we present the first iron-catalyzed selective synthesis of 1,2-disubstituted benzimidazoles via acceptorless ... Herein, we present the first iron-catalyzed selective synthesis of 1,2-disubstituted benzimidazoles via acceptorless ... of iron metal enable the provision of an eco-friendly and efficient catalytic method for the synthesis of benzimidazoles. ... of iron metal enable the provision of an ecofriendly and efficient catalytic method for the synthesis of benzimidazoles. ...
After determining the best active catalyst as 5A$_{\mathbf{1}}$, bearing the mesityl substituent on the benzimidazole ring with ... The incorporation of $N$-coordinated benzimidazole complexes of palladium gave high catalytic activity in the Suzuki-Miyaura ... benzimidazole ligands (2A$_{\mathbf{1}}$, 2A$_{\mathbf{2}}$, 3B$_{\mathbf{1}}$, 3B$_{\mathbf{2}}$, 3B$_{\mathbf{3}}$, and 4C ... A new series of $N,N$-type 2-(2-pyridyl)benzimidazole ligands (2A$_{\mathbf{1}}$, 2A$_{\mathbf{2}}$, 3B$_{\mathbf{1}}$, 3B$_{\ ...
... benzimidazole , C32H28N8 , CID 10481936 - structure, chemical names, physical and chemical properties, classification, patents ...
CH$NAME: 1H-Benzimidazole. CH$NAME: Benzimidazole. CH$COMPOUND_CLASS: Pesticides; Fungicides; Benzimidazoles. CH$FORMULA: C7H6N ... 1H-Benzimidazole; LC-ESI-QFT; MS2; CE: Ramp 20%-70% (nominal); R=30000; [M-H]-. Mass Spectrum ... RECORD_TITLE: 1H-Benzimidazole; LC-ESI-QFT; MS2; CE: Ramp 20%-70% (nominal); R=30000; [M-H]-. DATE: 2022.08.15. AUTHORS: ACESx ...
Text; Format: print ; Literary form: Not fiction Publication details: Geneva : World Health Organization, 2006Other title: Sixty-sixth report of the Joint FAO/WHO Expert Committee on Food Additives..Online access: Click here to access online Availability: Items available for loan: WHO HQ (3)Call number: WA 712 2006SI, ... ...
6-methoxy-1h-benzimidazole (C10H12N2OS) from the PQR. ...
Syed, Akheel Ahmed and Ayesha Syeda (2008) Spectrophotometric determination of certain benzimidazole proton pump inhibitors. ... Spectrophotometric method for the determination of certain proton pump inhibitors belonging to the benzimidazole class of ...
Genomic signatures of selection associated with benzimidazole drug treatments in Haemonchu Genomic signatures of selection ... This study addresses these knowledge gaps by using field populations of Haemonchus contortus with well-defined benzimidazole ... It also identified two additional genomic regions that likely contain benzimidazole resistance loci of secondary importance. ... contortus populations two from closed sheep flocks with an approximate 20 year history of frequent benzimidazole treatment, and ...
... benzimidazole + isoquinoline; Dirofilaria spp, Toxocara canis, Toxascaris leonina, Ancylostoma caninum, Uncinaria stenocephala ... Oxibendazole is a veteran benzimidazole introduced in the 1970s (by SMITH KLINE → PFIZER→ ZOETIS) that is rather scarcely used ... CANIMAX Palatable Allwormer for DOGS - VIRBAC - abamectin + oxibendazole + praziquantel - macrocyclic lactone + benzimidazole ...
Benzimidazoles / pharmacology* * CDC2 Protein Kinase / metabolism * Calcium-Calmodulin-Dependent Protein Kinase Kinase / ...
Dive into the research topics of Oxomolybdenum (v) complexes of benzimidazole and 2 - substituted benzimidazoles. Together ...
Isotonitazene or protonitazene, other benzimidazole-opioids, were identified in two cases.. †††† Number of detections in other ... These findings demonstrate the contribution of both para-fluorofentanyl and the benzimidazole-opioid metonitazene to ... a benzimidazole-opioid, and para-fluorofentanyl (both in combination with fentanyl), are being encountered more often in the ... and toxicology laboratories should be aware of the increased presence of para-fluorofentanyl and the benzimidazole class of ...
Name of test material : 5-methoxy-1,3-dihydro-2H-benzimidazole-2-thione. - Molecular formula : C8H8N2OS. - Molecular weight : ...
Benzimidazoles. en. dc.subject.mesh. Tylosin. en. dc.subject.mesh. Risk Assessment. en. ...
Categories: Benzimidazoles Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, CopyrightRestricted 3 ...
budding uninhibited by benzimidazoles 1 homolog beta. *hBUBR1. *MAD3/BUB1-related protein kinase ...
N. americanus Benzimidazole Resistance and β-Tubulin SNP Changes. Because 26 participants were positive for N. americanus ... data). Reports of benzimidazole resistance are increasing in the literature on veterinary medicine; resistance in canine ... First identification of the F200Y SNP in the β-tubulin gene linked to benzimidazole resistance in Ancylostoma caninum. Vet ... Molecular analysis of the β-tubulin gene of human hookworms as a basis for possible benzimidazole resistance on Pemba Island. ...
3-(diethylamino)-7-oxo-7H-[1]benzopyrano[3,2:3,4]pyrido[1,2-a]benzimidazole-6-carbonitrile. ...
AE treatment options include surgery, if possible, as well as Benzimidazole-based chemotherapy (BZ). Given that the cellular ... We propose that BI 2536 and related compounds are promising drugs to complement current benzimidazole treatment for achieving ... Current anti-AE chemotherapy using benzimidazoles is ineffective in eliminating the germinative cell population, thus leading ... Current treatment options, using benzimidazoles, are parasitostatic only, and thus obviously not effective in germinative cell ...
Proton‐conducting polymers based on benzimidazoles and sulfonated benzimidazoles. JA Asensio, S Borr s, P G mez‐Romero ... Proton-conducting membranes based on benzimidazole polymers for high-temperature PEM fuel cells. A chemical quest. JA Asensio, ... Polymer electrolyte fuel cells based on phosphoric acid-impregnated poly (2, 5-benzimidazole) membranes. JA Asensio, S Borr s, ... Proton-conducting membranes based on poly (2, 5-benzimidazole)(ABPBI) and phosphoric acid prepared by direct acid casting. JA ...
Benzimidazole (51-17-2) Benzimidazol;>>>. Jiangsu Haixiang Chemical Industry Co.,Ltd. * Inquire ...
PRECAUTIONS: Before taking albendazole, tell your doctor or pharmacist if you are allergic to it; or to other benzimidazole ...
chloramphenicol, florfenicol, florfenicol-amine, thiamphenicol & benzimidazoles £306.00 Veterinary Medicines in Pig Kidney ...
Activity of the anthelmintic benzimidazoles against Giardia lamblia in vitro. Journal of infectious diseases, 1990, 162:1408- ... has been proved to be effective in in vitro settings and asserted to be the most effective antihelminthic benzimidazole [18]. ...
Haro Dominguez, P.; Grygiel, K.; Weber, J.: Nanostructured poly(benzimidazole) membranes by N-alkylation. Express Polymer ...
If this is due to differential benzimidazole drug efficacy for different hookworm species remains unclear. ...
benzimidazoles. Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, ... 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole. Antra. Audazol. Belmazol. Ceprandal. ... 5-Methoxy-2-(((4-methoxy-3-methyl-5-hydroxymethyl-2-pyridinyl)methyl)sulfinyl)-1H-benzimidazole. C17H19N3O4S. CMZHQFXXAAIBKE- ... rac-5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole. chebi_ontology. ...
  • Benzimidazoles are important N -heteroaromatic compounds with various biological activities and pharmacological applications. (frontiersin.org)
  • Spectrophotometric method for the determination of certain proton pump inhibitors belonging to the benzimidazole class of compounds has been developed. (uni-mysore.ac.in)
  • More recently, another class of compounds known as benzimidazole-opioids have begun appearing in cities across the country as adulterants in the heroin supply, adding a new threat to public health ( 3 ). (cdc.gov)
  • Proton-conducting membranes based on benzimidazole polymers for high-temperature PEM fuel cells. (google.es)
  • Nanostructured poly(benzimidazole) membranes by N-alkylation. (mpg.de)
  • The incorporation of $N$-coordinated benzimidazole complexes of palladium gave high catalytic activity in the Suzuki-Miyaura coupling of aryl halides substrates. (tubitak.gov.tr)
  • Although praziquantel is more effective against protoscoleces than benzimidazole, it is not indicated alone in the treatment of alveolar echinococcosis because it is totally ineffective against larval growth. (medscape.com)
  • Substituted 2-(2''-pyridyl)benzimidazole palladium(II) complexes as an" by MAHMUT ULUSOY, NURDAL ÖNCEL et al. (tubitak.gov.tr)
  • Overall, the nursery workers had levels of the metabolite methyl-5- hydroxy-2-benzimidazole-carbamate (5-HBC) in the urine ranging from 3.0 to 87.0 micromoles/mole creatinine. (cdc.gov)
  • The earth abundance and low toxicity of iron metal enable the provision of an eco-friendly and efficient catalytic method for the synthesis of benzimidazoles. (frontiersin.org)
  • This study provides the first known direct genome -wide evidence for any parasitic nematode, that the isotype-1 ß- tubulin gene is quantitatively the single most important benzimidazole resistance locus. (bvsalud.org)
  • Physicians, medical examiners, and toxicology laboratories should be aware of the increased presence of para -fluorofentanyl and the benzimidazole class of opioids ¶ when treating patients in the emergency department or identifying these substances postmortem. (cdc.gov)
  • Based on their attractive biological profiles, the synthesis of 1,2-disubstituted benzimidazoles has gained the interest of synthetic chemists. (frontiersin.org)
  • Of these, the 1,2-disubstituted benzimidazole is considered a privileged scaffold in drug discovery. (frontiersin.org)
  • Genomic signatures of selection associated with benzimidazole drug treatments in Haemonchus contortus field populations. (bvsalud.org)
  • This study addresses these knowledge gaps by using field populations of Haemonchus contortus with well-defined benzimidazole treatment histories , leveraging a recently completed chromosomal-scale reference genome assembly. (bvsalud.org)
  • We generated a panel of 49,393 genomic markers to genotype 20 individual adult worms from each of four H. contortus populations two from closed sheep flocks with an approximate 20 year history of frequent benzimidazole treatment , and two populations with a history of little or no treatment . (bvsalud.org)
  • Although these drugs have not been formally authorized for use in this indication, evidence of their efficacy against E multilocularis in vitro and data from pilot trials in humans may support their use in rare cases in which inefficacy or contraindication of benzimidazoles is demonstrated. (medscape.com)
  • Representative drugs containing 1,2-disubstituted benzimidazole. (frontiersin.org)
  • 13. Deoxynucleosides with benzimidazoles as aglycone moiety are potent anti cancer agents. (nih.gov)

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