Aminobiphenyl Compounds: Biphenyl compounds substituted in any position by one or more amino groups. Permitted are any substituents except fused rings.Tanning: A process of preserving animal hides by chemical treatment (using vegetable tannins, metallic sulfates, and sulfurized phenol compounds, or syntans) to make them immune to bacterial attack, and subsequent treatments with fats and greases to make them pliable. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Guaiacol: An agent thought to have disinfectant properties and used as an expectorant. (From Martindale, The Extra Pharmacopoeia, 30th ed, p747)Biotransformation: The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.Textile Industry: The aggregate business enterprise of manufacturing textiles. (From Random House Unabridged Dictionary, 2d ed)2-Naphthylamine: A naphthalene derivative with carcinogenic action.Benzidines: Very toxic industrial chemicals. They are absorbed through the skin, causing lethal blood, bladder, liver, and kidney damage and are potent, broad-spectrum carcinogens in most species.1-Naphthylamine: A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.Occupational Exposure: The exposure to potentially harmful chemical, physical, or biological agents that occurs as a result of one's occupation.Urinary Bladder Neoplasms: Tumors or cancer of the URINARY BLADDER.Urinary Bladder: A musculomembranous sac along the URINARY TRACT. URINE flows from the KIDNEYS into the bladder via the ureters (URETER), and is held there until URINATION.Antipyrine: An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)Dipterocarpaceae: A plant family of the order Theales.Reagent Strips: Narrow pieces of material impregnated or covered with a substance used to produce a chemical reaction. The strips are used in detecting, measuring, producing, etc., other substances. (From Dorland, 28th ed)Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.PeroxidasesImmunochromatography: A type of affinity chromatography where ANTIBODIES are used in the affinity capture reaction on the solid support, in the mobile phase, or both.Azo CompoundsAmaranth Dye: A sulfonic acid-based naphthylazo dye used as a coloring agent for foodstuffs and medicines and as a dye and chemical indicator. It was banned by the FDA in 1976 for use in foods, drugs, and cosmetics. (From Merck Index, 11th ed)Coloring Agents: Chemicals and substances that impart color including soluble dyes and insoluble pigments. They are used in INKS; PAINTS; and as INDICATORS AND REAGENTS.Arachidonic Acid: An unsaturated, essential fatty acid. It is found in animal and human fat as well as in the liver, brain, and glandular organs, and is a constituent of animal phosphatides. It is formed by the synthesis from dietary linoleic acid and is a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes.FANFT: A potent nitrofuran derivative tumor initiator. It causes bladder tumors in all animals studied and is mutagenic to many bacteria.Trichloroacetic Acid: A strong acid used as a protein precipitant in clinical chemistry and also as a caustic for removing warts.Seminal Vesicles: A saclike, glandular diverticulum on each ductus deferens in male vertebrates. It is united with the excretory duct and serves for temporary storage of semen. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Prostaglandin Endoperoxides: Precursors in the biosynthesis of prostaglandins and thromboxanes from arachidonic acid. They are physiologically active compounds, having effect on vascular and airway smooth muscles, platelet aggregation, etc.Proadifen: An inhibitor of drug metabolism and CYTOCHROME P-450 ENZYME SYSTEM activity.Phenoperidine: A narcotic analgesic partly metabolized to meperidine in the liver. It is similar to morphine in action and used for neuroleptanalgesia, usually with droperidol.Urine: Liquid by-product of excretion produced in the kidneys, temporarily stored in the bladder until discharge through the URETHRA.Urothelium: The epithelial lining of the URINARY TRACT.Nephrolithiasis: Formation of stones in the KIDNEY.Urinalysis: Examination of urine by chemical, physical, or microscopic means. Routine urinalysis usually includes performing chemical screening tests, determining specific gravity, observing any unusual color or odor, screening for bacteriuria, and examining the sediment microscopically.Magnesium Silicates: A generic term for a variety of compounds that contain silicon, oxygen, and magnesium, and may contain hydrogen. Examples include TALC and some kinds of ASBESTOS.Adsorption: The adhesion of gases, liquids, or dissolved solids onto a surface. It includes adsorptive phenomena of bacteria and viruses onto surfaces as well. ABSORPTION into the substance may follow but not necessarily.Spectroscopy, Fourier Transform Infrared: A spectroscopic technique in which a range of wavelengths is presented simultaneously with an interferometer and the spectrum is mathematically derived from the pattern thus obtained.TurkeySpectrophotometry, Infrared: Spectrophotometry in the infrared region, usually for the purpose of chemical analysis through measurement of absorption spectra associated with rotational and vibrational energy levels of molecules. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Amish: An ethnic group with shared religious beliefs. Originating in Switzerland in the late 1600s, and first migrating to the mid-Atlantic, they now live throughout Eastern and Mid-Western United States and elsewhere. Communities are usually close-knit and marriage is within the community.Proteomics: The systematic study of the complete complement of proteins (PROTEOME) of organisms.Isotopes: Atomic species differing in mass number but having the same atomic number. (Grant & Hackh's Chemical Dictionary, 5th ed)Acetylcysteine: The N-acetyl derivative of CYSTEINE. It is used as a mucolytic agent to reduce the viscosity of mucous secretions. It has also been shown to have antiviral effects in patients with HIV due to inhibition of viral stimulation by reactive oxygen intermediates.Horseradish Peroxidase: An enzyme isolated from horseradish which is able to act as an antigen. It is frequently used as a histochemical tracer for light and electron microscopy. Its antigenicity has permitted its use as a combined antigen and marker in experimental immunology.3,3'-Dichlorobenzidine: A material used in the manufacture of azo dyes that is toxic to skin and carcinogenic in several species.Chemical Industry: The aggregate enterprise of manufacturing and technically producing chemicals. (From Random House Unabridged Dictionary, 2d ed)ChlorobenzenesWest VirginiaAir Pollutants, Occupational: Air pollutants found in the work area. They are usually produced by the specific nature of the occupation.Decontamination: The removal of contaminating material, such as radioactive materials, biological materials, or CHEMICAL WARFARE AGENTS, from a person or object.Hygiene: The science dealing with the establishment and maintenance of health in the individual and the group. It includes the conditions and practices conducive to health. (Webster, 3d ed)PennsylvaniaNational Institute for Occupational Safety and Health (U.S.): An institute of the CENTERS FOR DISEASE CONTROL AND PREVENTION which is responsible for assuring safe and healthful working conditions and for developing standards of safety and health. Research activities are carried out pertinent to these goals.

Peroxygenase metabolism of N-acetylbenzidine by prostaglandin H synthase. Formation of an N-hydroxylamine. (1/124)

Synthesis of prostaglandin H2 by prostaglandin H synthase (PHS) results in a two-electron oxidation of the enzyme. An active reduced enzyme is regenerated by reducing cofactors, which become oxidized. This report examines the mechanism by which PHS from ram seminal vesicle microsomes catalyzes the oxidation of the reducing cofactor N-acetylbenzidine (ABZ). During the conversion of 0.06 mM ABZ to its final end product, 4'-nitro-4-acetylaminobiphenyl, a new metabolite was observed when 1 mM ascorbic acid was present. Similar results were observed whether 0.2 mM arachidonic acid or 0.5 mM H2O2 was used as the substrate. This metabolite co-eluted with synthetic N'-hydroxy-N-acetylbenzidine (N'HA), but not with N-hydroxy-N-acetylbenzidine. The new metabolite was identified as N'HA by electrospray ionization/MS/MS. N'HA represented as much as 10% of the total radioactivity recovered by high pressure liquid chromatography. When N'HA was substituted for ABZ, PHS metabolized N'HA to 4'-nitro-4-acetylaminobiphenyl. Inhibitor studies demonstrated that metabolism was due to PHS, not cytochrome P-450. The lack of effect of 5,5-dimethyl-1-pyrroline N-oxide, mannitol, and superoxide dismutase suggests the lack of involvement of one-electron transfer reactions and suggests that hydroxyl radicals and superoxide are not sources of oxygen or oxidants. Oxygen uptake studies did not demonstrate a requirement for molecular oxygen. When [18O]H2O2 was used as the substrate, 18O enrichment was observed for 4'-nitro-4-acetylaminobiphenyl, but not for N'HA. A 97% enrichment was observed for one atom of 18O, and a 17 +/- 7% enrichment was observed for two 18O atoms. The rapid exchange of 18O-N'HA with water was suggested to explain the lack of enrichment of N'HA and the low enrichment of two 18O atoms into 4'-nitro-4-acetylaminobiphenyl. Results demonstrate a peroxygenase oxidation of ABZ and N'HA by PHS and suggest a stepwise oxidation of ABZ to N'-hydroxy, 4'-nitroso, and 4'-nitro products.  (+info)

Human and Escherichia coli beta-glucuronidase hydrolysis of glucuronide conjugates of benzidine and 4-aminobiphenyl, and their hydroxy metabolites. (2/124)

Individuals exposed to carcinogenic aromatic amines excrete arylamine N- and O-glucuronide metabolites. This study assessed the susceptibility of selected glucuronides to hydrolysis by human and Escherichia coli beta-glucuronidase. N- or O-glucuronides were prepared with the following aglycones: benzidine, N-acetylbenzidine, N'-hydroxy-N-acetylbenzidine, N-hydroxy-N-acetylbenzidine, N-hydroxy-N,N'-diacetylbenzidine, 3-hydroxy-N,N'-diacetylbenzidine, 3-hydroxy-benzidine, 4-aminobiphenyl, N-hydroxy-4-aminobiphenyl, and N-hydroxy-N-acetyl-4-aminobiphenyl. The (3)H- and (14)C-labeled glucuronides were prepared with human or rat liver microsomes using UDP-glucuronic acid as cosubstrate. Each of the 10 glucuronides (6-12 microM) was incubated at pH 5.5 or 7.0 with either human recombinant (pure) or E. coli (commercial preparation) beta-glucuronidase for 30 min at 37 degrees C. Hydrolysis was measured by HPLC. Reaction conditions were optimized, using the O-glucuronide of N-hydroxy-N,N'-diacetylbenzidine. Both enzymes preferentially hydrolyzed O-glucuronides over N-glucuronides and distinguished between structural isomers. With E. coli beta-glucuronidase at pH 7.0, selectivity was demonstrated by the complete hydrolysis of N-hydroxy-N-acetyl-4-aminobiphenyl O-glucuronide in the presence of N-acetylbenzidine N-glucuronide, which was not hydrolyzed. Metabolism by both enzymes was completely inhibited by the specific beta-glucuronidase inhibitor saccharic acid-1,4-lactone (0.5 mM). The concentration of human beta-glucuronidase necessary to achieve significant hydrolysis of glucuronides was substantially more than the amount of enzyme reported previously to be present in urine under either normal or pathological conditions. The bacterial enzyme may hydrolyze O-glucuronides, but not N-glucuronides, in urine at neutral pH. Thus, the nonenzymatic hydrolysis of N-glucuronides by acidic urine is likely a more important source of free amine than enzymatic hydrolysis.  (+info)

Ultrastructural localization of light-induced lipid peroxides in the rat retina. (3/124)

PURPOSE: Localization of light-induced lipid peroxides in the rat retina at an ultrastructural level as benzidine-reactive substances. METHODS: Long-Evans rats with nondilated pupils were exposed to intense light of 6000 lux for 12 or 24 hours. Control animals were kept under physiological light conditions. Rats with dilated pupils were exposed to a light intensity of 50 lux or 150,000 lux for 1 hour. For ultrastructural localization the enucleated eyes were fixed in a 0.1-M cacodylate buffer (pH 7.4) containing 2% glutaraldehyde for 2 hours. Pieces of the superior part of the central eyecup were incubated overnight with tetramethylbenzidine (TMB; pH 3.0) at 4 degrees C, postfixed with 1.5% OSO4, and embedded for electron microscopy. RESULTS: In animals exposed to intense light, electron-dense structures appeared exclusively throughout the rod outer segments after an irradiation of 6000 lux for 24 hours or 150,000 lux for 1 hour and were absent in animals with nondilated pupils kept at physiological light conditions. Dilation of the pupils leads to the appearance of electron-dense structures after just 1 hour of 50 lux, whereas rats with nondilated pupils withstand even a 12-hour irradiation with 6000 lux. No electron-dense structures were found when no TMB was used in incubation. CONCLUSIONS: The appearance of electron-dense structures in the rod outer segments depends on the incubation with TMB and intensive light exposure of the rat. Dilation of the pupils lowers the threshold for the emergence of electron-dense structures significantly. This strongly supports the view that light-induced lipid peroxides in the rat retina are localized at an ultrastructural level as benzidine-reactive substances. This protocol presents a tool for the generation and ultrastructural localization of lipid peroxides in rat retinas.  (+info)

Glucuronidation of benzidine and its metabolites by cDNA-expressed human UDP-glucuronosyltransferases and pH stability of glucuronides. (4/124)

Although glucuronidation is considered a necessary step in aromatic amine-induced bladder cancer, the specific enzymes involved are not known. This study assessed the capacity of five different human recombinant UDP-glucuronosyltransferases expressed in COS-1 cells to glucuronidate benzidine, its metabolites and 4-aminobiphenyl. [(14)C]UDP-glucuronic acid was used as co-substrate. UGT1A1, UGT1A4 and UGT1A9 each metabolized all of the aromatic amines. UGT1A9 exhibited the highest relative rates of metabolism with preference for the two hydroxamic acids, N-hydroxy-N-acetylbenzidine and N-hydroxy-N,N'-diacetylbenzidine. UGT1A9 metabolized 4-aminobiphenyl approximately 50% faster than benzidine or N-acetylbenzidine. UGT1A4 N-glucuronidated N'-hydroxy- N-acetylbenzidine at the highest relative rate compared with the other transferases. UGT1A6 was effective in metabolizing only four of the eight aromatic amines tested. UGT1A1 demonstrated more extensive metabolism of the hydroxamic acid, N-hydroxy-N,N'-diacetylbenzidine, and the ring oxidation product, 3-OH-N,N'-diacetylbenzidine, than it did for the other six amines. UGT2B7 was the only product of the UGT2 gene family examined and it metabolized all the aromatic amines at similar low relative levels compared with a preferred substrate, 4-OH-estrone. The K(m) values for N-acetylbenzidine metabolism by UGT1A1 and UGT1A4 were 0.37 +/- 0.14 and 1.8 +/- 0.4 mM, respectively. The O-glucuronide of 3-OH-N,N'-diacetylbenzidine was not hydrolyzed during a 24 h 37 degrees C incubation at either pH 5. 5 or 7.4. Likewise, the O-glucuronide of 3-OH-benzidine was stable at pH 7.4, with 52% remaining at pH 5.5 after 24 h. These results suggest the following relative ranking of transferase metabolism: UGT1A9 > UGT1A4 > > UGT2B7 > UGT1A6 approximately UGT1A1. The relative pH stability of O-glucuronides is consistent with a role in detoxification and excretion of aromatic amines, while the acid lability of N-glucuronides is consistent with delivery of these amines to the bladder epithelium for activation, resulting in DNA adducts which may lead to mutations.  (+info)

H(2)O(2) detection from intact mitochondria as a measure for one-electron reduction of dioxygen requires a non-invasive assay system. (5/124)

Evaluation of the existence of superoxide radicals (O*-(2)), the site of generation and conditions required for one-e(-) transfer to oxygen from biological redox systems is a prerequisite for the understanding of the deregulation of O(2) homeostasis leading to oxidative stress. Mitochondria are increasingly considered the major O*-(2) source in a great variety of diseases and the aging process. Contradictory reports on mitochondrial O*-(2) release prompted us to critically investigate frequently used O*-(2) detection methods for their suitability. Due to the impermeability of the external mitochondrial membrane for most constituents of O*-(2) detection systems we decided to follow the stable dismutation product H(2)O(2). This metabolite was earlier shown to readily permeate into the cytosol. With the exception of tetramethylbenzidine none of the chemical reactants indicating the presence of H(2)O(2) by horseradish peroxidase-catalyzed absorbance change were suited due to solubility problems or low extinction coefficients. Tetramethylbenzidine-dependent H(2)O(2) detection was counteracted by rereduction of the dye through e(-) carriers of the respiratory chain. Although the fluorescent dyes scopoletin and homovanillic acid were found to be suited for the detection of mitochondrial H(2)O(2) release, fluorescence change was strongly affected by mitochondrial protein constituents. The present study has resolved this problem by separating the detection system from H(2)O(2)-producing mitochondria.  (+info)

Examination of low-incidence brain tumor responses in F344 rats following chemical exposures in National Toxicology Program carcinogenicity studies. (6/124)

Neoplasms in the brain are uncommon in control Fischer 344 (F344) rats; they occur at a rate of less than 1% in 2-yr toxicity/carcinogenicity studies. Furthermore, only 10 of nearly 500 studies conducted by the National Toxicology Program (NTP) showed any evidence of chemically related neoplastic effects in the brain. Generally, the brain tumor responses were considered equivocal, because the characteristics of potential neurocarcinogenic agents (such as statistically significant increased incidences, decreased latency and/or survival, and demonstration of dose-response relationships) were not observed. A thorough examination, including comparisons with a well-established historical database, is often critical in evaluating rare brain tumors. Chemicals that gave equivocal evidence of brain tumor responses were generally associated with carcinogenicity at other sites, and many chemicals were mutagenic when incubated with metabolic activating enzymes. Other factors that were supportive of the theory that marginal increases in brain tumor incidence were related to chemical exposure were that (a) some of the tumors were malignant, (b) no brain neoplasms were observed in concurrent controls from some studies, and/or (c) brain tumors were also seen following exposure to structurally related chemicals. In 2-yr studies in F344 rats (studies conducted by the NTP), equivocal evidence of carcinogenicity was observed for the following 9 chemicals: isoprene, bromoethane, chloroethane, 3,3'-dimethylbenzidine dihydrochloride, 3,3'-dimethoxybenzidine dihydrochloride, furosemide, C.I. direct blue 15, diphenhydramine hydrochloride, and 1-H-benzotriazole. Glycidol was the only chemical evaluated by the NTP with which there was clear evidence of brain tumor induction in F344 rats. Clarification of the potential neurocarcinogenic risks of chemicals that produce equivocal evidence of a brain tumor response in conventional 2-yr rodent studies may be aided by the use of transgenic mouse models that exhibit genetic alterations that reflect those present in human brain tumors as well as by the use of in utero exposures.  (+info)

A new group of potent inducers of differentiation in murine erythroleukemia cells. (7/124)

This report identifies a group of compounds, polymethylene bisacetamides (acetylated diamines), which are potent inducers of erythroid differentiation in murine erythroleukemia cells. A known inducing agent, N-methylacetamide, was dimerized through varying numbers of methylenes in an attempt to increase the local effective concentration at adjacent target sites. The simple dimer was no more effective than N-methylacetamide alone; introduction of five to eight methylenes between acetamide groups substantially increased the effectiveness of these compounds. The hexamethylene bisacetamide was active between 0.5 mM and 5 mM; the percentage of cells induced and the rate at which they were recruited to differentiation was dependent upon the concentration of inducer within this range. At 5 mM hexamethylene bisacetamide essentially the entire population (greater than 99%) was induced to a pathway of erythroid differentiation which was greater differentiation of the cultured cells than with any inducer yet tested.  (+info)

Hypochlorous acid-mediated activation of N-acetylbenzidine to form N'-(3'-monophospho-deoxyguanosin-8-yl)-N-acetylbenzidine. (8/124)

Hypochlorous acid (HOCl), a chemically reactive oxidant, is an important component of the inflammatory response and may contribute to carcinogenesis. This study assessed the possible activation of N-acetylbenzidine (ABZ) by HOCI to form a specific DNA adduct, N'-(3'-monophospho-deoxyguanosin-8-yl)-N-acetylbenzidine. HOCl was incubated with 0.06 mM 3H-ABZ, and transformation assessed by HPLC. Similar results were observed at pH 5.5 or 7.4. A linear increase in transformation was observed from 0.025 to 0.1 mM HOCl with up to 80% of ABZ changed. Approximately, 2 nmoles of HOCI oxidized 1 nmole of ABZ. N-oxidation products of ABZ metabolism, such as N'-hydroxy-N-acetylbenzidine, were not detected. Oxidation of ABZ was prevented by taurine, DMPO, glutathione, and ascorbic acid, whereas mannitol was without effect. Results are consistent with a radical mechanism. In the presence of 2'-deoxyguanosine 3'-monophosphate (dGp), a new product (dGp-ABZ) was observed. The same adduct was observed with DNA. dGp-ABZ was found to be quite stable (>80% remaining) at 70 degrees C in pH 5.5 (60 min) and 7.4 (240 min). Electrospray mass spectrometry indicated that dGp-ABZ was N'-(3'-monophospho-deoxyguanosin-8-yl)-N-acetylbenzidine, and this was confirmed by NMR. 32P-postlabeling in combination with TLC and HPLC determined that the adduct made by either HOCl or prostaglandin H synthase oxidation of ABZ in the presence of dGp or DNA was dGp-ABZ. Thus, HOCI activates ABZ to form dGp-ABZ and may be responsible for the presence of this adduct in peripheral white blood cells from workers exposed to benzidine. Reaction of ABZ with HOCl provides an easy, convenient method for preparing dGp-ABZ.  (+info)

The adsorption of benzidine by sepiolite obtained from Eskisehir (Turkey) has been studied by Fourier-transform infrared spectroscopy. A deep green colouration results on reaction of benzidine and sepiolite. In the IR spectrum of benzidine treated sepiolite ν(C-N+) vibrational modes of the uni- and di-positive radical cations are observed in addition to vibrational modes of coordinated benzidine. Spectroscopic results indicate that the principle adsorption mechanism for benzidine is coordination to surface hydroxyls from nitrogen lone pairs and to a relatively small extent, formation of radical cations. No physical sorbed species have been detected. It must be noted that the adsorption of benzidine affected the hydroxyl group vibrations of sepiolite.. ...
Tetramethylbenzidine 54827-17-7 MSDS report, Tetramethylbenzidine MSDS safety technical specifications search, Tetramethylbenzidine safety information specifications ect.
Information about the carcinogenicity of benzidine (92875) in man and in experimental animals is reviewed, along with results of studies on the metabolism of benzidine and azo compounds, and epidemiological surveys of industries that use azo dyes. The author concludes that workers exposed to benzidine based dyes may metabolically convert the dyes to carcinogenic amine. The number of workers with p
The cooxidative metabolism of the urinary bladder carcinogen benzidine was examined using renal inner medullary microsomes. The products of [14C]benzidine metabolism were recovered in the aqueous but not in the organic soluble fraction of reaction mixtures. The reactive metabolites formed during cooxidative metabolism of benzidine bound to DNA and transfer RNA. Cooxidative metabolism of benzidine and subsequent binding to nucleic acids was dependent upon specific fatty acid substrates and was blocked by inhibitors of prostaglandin endoperoxide synthetase. The ratio of the rates of benzidine product formation was approximately 10:3:1 (trichloroacetic acid precipitable:non-trichloroacetic acid precipitable:transfer RNA bound) over a wide range of arachidonic acid concentrations. Cumene hydroperoxide also initiated cooxidative metabolism of benzidine but was less effective than was arachidonic acid. In contrast to arachidonic acid, cumene hydroperoxide-mediated metabolism of benzidine and guaiacol ...
We evaluated the influence of urine pH on the proportion of urinary benzidine (BZ) and N-acetylbenzidine present in the free, unconjugated state and on exfoliated urothelial cell DNA adduct levels in 32 workers exposed to BZ in India. Postworkshift urine pH was inversely correlated with the proportions of BZ (r = -0.78; P , 0.0001) and N-acetylbenzidine (r = -0.67; P , 0.0001) present as free compounds. Furthermore, the average of each subjects pre- and postworkshift urine pH was negatively associated with the predominant urothelial DNA adduct (P = 0.0037, adjusted for urinary BZ and metabolites), which has been shown to cochromatograph with a N-(3-phosphodeoxyguanosin-8-yl)-N-acetylbenzidine adduct standard. Controlling for internal dose, individuals with urine pH , 6 had 10-fold higher DNA adduct levels compared to subjects with urine pH , or = 7. As reported previously, polymorphisms in NAT1, NAT2, and GSTM1 had no impact on DNA adduct levels. This is the first study to demonstrate that ...
The epidemiological studies showed that occupational exposure to commercial benzidine alone was strongly associated with bladder cancer. In the same studies, exposure to 2-naphthylamine alone was similarly associated with bladder cancer. A number of case reports from several countries support the relationship between this neoplasm and occupational exposure to benzidine.. Subsequent evaluations: Vol. 29 (1982); Suppl. 7 (1987). ...
Identification of the N-acetylcysteine conjugate of benzidine formed in the peroxidase activation system.: Benzidine is oxidized by the peroxidase/H2O2 system,
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A dry reagent test strip for determining the concentration of an analyte in a liquid sample is described. The test strip has a matrix containing reagent detection chemistry, which includes an oxidase enzyme that can utilize the analyte as a substrate forming hydrogen peroxide, a benzidine dye precursor, a peroxidase enzyme, and an antipyrine compound. The addition of an antipyrine compound to the reagent detection chemistry provides a standard concentration graph which is substantially linear in a desired range of analyte concentration. The precision and accuracy of reading the test strip are enhanced.
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Microsomal enzyme preparations from dog liver, kidney, and bladder were used to assess the prostaglandin H synthasecatalyzed activation of carcinogenic aromatic amines to bind covalently to proteins and nucleic acids. Benzidine, a urinary bladder carcinogen, bound to protein of bladder transitional epithelial and renal inner and outer medullary microsomes and was dependent upon addition of arachidonic acid, but not upon reduced nicotinamide adenine dinucleotide phosphate. Bladder transitional epithelial microsomes also activated o-dianisidine, 4-aminobiphenyl, and 2-naphthylamine to bind to protein and transfer RNA and benzidine and o-dianisidine to bind DNA. Cosubstrate and inhibitor specificities were consistent with activation by prostaglandin H synthase. Binding of benzidine to protein was not observed with either hepatic or renal cortical microsomes upon addition of arachidonic acid or reduced nicotinamide adenine dinucleotide phosphate.. Prostaglandin H synthase and mixed-function ...
0058] The additional layer 510 may be p-doped. A dopant provided for the additional layer 510 in various working examples is a copper complex. In various working examples, the additional layer 510 is doped with the dopant with a dopant concentration within a range from about 1% to about 20%, for example within a range from about 1% to about 15%, for example within a range from about 2% to about 8%. The following materials may be used as part of the matrix material of the additional layer 110: NPB (N,N-bis(1-naphthyl)-N,N-bis(phenyl)benzidine), β-NPB (N,N-bis(naphthalen-2-yl)-N,N-bis(phenyl)benzidine), TPD (N,N-bis(3-methylphenyl)-N,N-bis(phenyl)benzidine), N,N-bis(1-naphthyl)-N,N-bis(phenyl)-2,2-dimethylbenzidine, spiro-TPD (N,N-bis(3-methylphenyl)-N,N-bis(phenyl)-9,9-spirobifluorene), spiro-NPB (N,N-bis(1-naphthyl)-N,N-bis(phenyl)-9,9-spirobifluorene), DMFL-TPD (N,N-bis(3-methylphenyl)-N,N-bis(phenyl)-9,9-dimethylfluorene, DMFL-NPB ...
Direct Black 19 {H.S. Code}: 3204140000 {Color Index}: C.I. Direct Black 19 {CAS No.}: 6428-31-5 {Molecular Structure}: {Molecular Formula}: C34H27N13Na2
In this work, uniformly-dispersed platinum nanoparticles (PtNPs) were synthesized by a simple chemical reduction method, in which citric acid and sodium borohydride acted as a stabilizer and reducer, respectively. An ultrasensitive colorimetric sensor for the facile and rapid detection of Ag+ ions was constructed based on the peroxidase mimetic activities of the obtained PtNPs, which can catalyze the oxidation of 3,3,5,5-tetramethylbenzidine (TMB) by H2O2 to produce colored products. The introduced Ag+ would be reduced to Ag0 by the capped citric acid, and the deposition of Ag0 on the PtNPs surface, can effectively inhibit the peroxidase-mimetic activity of PtNPs. Through measuring the maximum absorption signal of oxidized TMB at 652 nm, ultra-low detection limits (7.8 pM) of Ag+ can be reached. In addition to such high sensitivity, the colorimetric assay also displays excellent selectivity for other ions of interest and shows great potential for the detection of Ag+ in real water samples.
appendicitis.. Principle:. The SeraSpot® Anti-Yersinia-6 IgG / SeraSpot® Anti-Yersinia-6 IgA test is a solid phase immunoassay based on the use of recombinant Yersinia proteins as capture antigens printed in array arrangement (spot array) on the bottom of the wells of 96-well microtiter plates. The recombinant antigens serve as capture molecules for antibodies against Yersinia antigens. Bound antibodies are detected by horseradish peroxidase-(HRP)-labeled antibodies against human antibodies of IgG- or IgA-type by substrate reaction with hydrogen peroxide and 3,3,5,5-tetramethylbenzidine (TMB). At the site of formed immune complexes blue spots are developed by precipitated product from colorless substrate solution. Color intensity is correlated to the antibody concentration. Pale blue to dark blue spots are visible by eye.. Article No.:. ...
Connective tissue diseases are characterized by typical autoantibody profiles, all detectable with SeraSpot® ANA-12 IgG.. Principle of the test:. SeraSpot® ANA-12 IgG is a solid phase immunoassay based on the use of recombinant or purified native proteins / protein complexes and dsDNA as capture antigens printed in array arrangement (microspot array) on the bottom of the wells of 96-well microtiter plates. The antigens serve as capture molecules for autoantibodies to nuclear antigens (ANA). Bound antibodies are detected by Horseradish Peroxidase-(HRP)-labeled antibodies against human antibodies of IgG-type by substrate reaction with hydrogen peroxide and 3,3,5,5-Tetramethylbenzidine (TMB). At the site of formed immune complexes blue spots are developed by precipitated product from colorless substrate solution. Color intensity is correlated to the antibody concentration. Pale blue to dark blue spots are visible by eye.. Art. No.:. ...
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A simple, sensitive and rapid spectrophotometric method for the determination of anions, nitrite and nitrate has been described. Determination of nitrite is by means of reactions involving tetrazotisation of Benzidine, followed by coupling withN,N-dimethylaniline and determination of nitrate is mainly based on reduction of nitrate to nitrite by using granular Zinc in NaCl. The produced nitrite is then availed to tetrazotize the Benzidine, which is then coupled with N,N-dimethylaniline to form pinkish red colored an azo dye in acidic medium. Measured the absorbance of resulted colored dye solution at 538 nm. Amount of reagents required is optimised and the extent of tolerance limit by the diverse ions was investigated. The Beer-Lambert s linearity range for Benzidine- N,N-dimethylaniline couple was found to be 0.05 to 0.3g/mL of nitrite with molar absorptivity 3.475x10Lmol-1cm-1 and sandell s sensitivity 3.3152x10-4gcm-2. The evaluated detection limit and quantization limit for the determination ...
Hydrazobenzene is a hydrazine derivative selected for bioassay by the National Cancer Institute because of the documented carcinogenicity of the parent compound hydrazine and of certain substituted hydrazines. Treatment of hydrazobenzene with hot mineral acid results in the production of benzidine (the so-called "benzidine rearrangement") and hydrazobenzene finds application in the dye manufacturing industry as a precursor of this important dye intermediate and potent carcinogen.. A bioassay of technical-grade hydrazobenzene for possible carcinogenicity was conducted using Fischer 344 rats and B6C3F1 mice. Hydrazobenzene was administered in the feed, at either of two concentrations, to groups of 50 male and 47 to 50 females animals of each species. The time-weighted average dietary concentrations used in the rat bioassay were 0.008, 0.03, 0.004, and 0.01 percent for low dose males, high dose males, low dose females, and high dose females, respectively. The time-weighted average dietary ...
The short-term toxicity to aquatic invertebrates has been evaluated taken into account the already existing data on the Direct Blue 199 Na form (i.e. Direct Blue 199_Na). The usage of information on Direct Blue 199_Na, which has the same main component and with a different counter ion, can be considered as suitable and appropriated because the difference in salification is expected to not influence the characteristics related to the specific end-point. The impurity profile does not impact on the read across proposed. Details on the approach followed are included in the document attached to the IUCLID section 13. The acute toxicity of Direct Blue 199_Na to Daphnia magna was determined according to the OECD Guideline 202. The test was carried out under static exposure conditions for a period of 48 hours, at the following concentrations: 1, 10 and 100 mg/l. After 24 and 48 hours of incubation no significant effects (, 10 % of a total of 40 individuals) were observed at all test concentrations and ...
Megavat Direct Black GV is a black vat dye derived from anthraquinone. It is insoluble in water except during the dyeing process. This product comes in ...
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This study describes the preparation of nanoprotein particles having lignin peroxidase (LiP) using a photosensitive microemulsion polymerization technique. The protein-based nano block polymer was synthesized by cross-linking of ligninase enzyme with ruthenium-based aminoacid monomers. This type polymerization process brought stability in different reaction conditions, reusability and functionality to the protein-based nano block polymer system when compared the traditional methods. After characterization of the prepared LiP copolymer nanoparticles, enzymatic activity studies of the nanoenzymes were carried out using tetramethylbenzidine (TMB) as the substrate. The parameters such as pH, temperature and initial enzyme concentration that affect the activity, were investigated by using prepared nanoLip particles and compared to free LiP. The reusability of the nano-LiP particles was also investigated and the obtained results showed that the nano-LiP particles exhibited admirable potential as a reusable
The MP Diagnostics HIV-1/2 ELISA 4.0 is an antigen sandwich immunoassay. The wells of the polystyrene microplate strips are coated with recombinant HIV antigens (gp41, gp120, and gp-36) expressed in E.coli. The conjugate is based on a second set of recombinant HIV antigens expressing the same epitopes as the pre-coated antigens, which is conjugated to horseradish peroxidase. Human serum or plasma, are incubated in these coated wells. HIV-1/2 specific antibodies, if present, will bind to the antigens immobilised on the solid phase. After incubation, the wells are thoroughly washed to remove unbound materials and conjugate is added to the wells. The antigens of the conjugate will bind to any antigen-antibody complexes previously formed and excess unbound conjugate are removed by washing. Colourless solutions containing urea peroxide and tetramethylbenzidine are then added to each well. The presence of specific antibodies is indicated by the presence of a blue colour after incubation, which changes ...
This Borrelia burgdorferi (Lyme) assay is based on a synthetic peptide antigen (C6 peptide) in microwell enzyme-linked immunosorbent assay (ELISA) format. The antigen is derived from the vlsE protein of Borrelia burgdorferi. In the assay procedure, diluted cerebrospinal fluid specimens are added and incubated in wells of an antigen-coated microwell plate. Antibodies specific to the C6 peptide in the specimen are bound by the immobilized antigen, and unbound antibodies are removed by wash steps. The bound antibodies are detected by addition of a horseradish peroxidase-conjugated goat antihuman IgG/IgM conjugate. After removal of excess conjugate by further wash steps, a chromogenic peroxidase substrate containing tetramethylbenzidine is added. A blue-green product is produced in wells where antibodies have been bound to the antigen. The color development reaction is quenched by addition of dilute sulfuric acid, after which optical absorbance at 450 nm is measured in each well using an ELISA plate ...
A quantitative method was developed to estimate the concentration of cytochrome (cyt) f in isolated thylakoids, using sodium dodecyl sulfate-polyacrylamide gel electrophoresis followed by staining with a heme-specific reagent containing 3,3′,5,5′-tetramethylbenzidine and hydrogen peroxide. This densitometric technique was at least as sensitive as difference spectroscopy. Analysis of thylakoid preparations by densitometry of stained bands using cyt c as standard gave molar ratios of cyt/chlorophyll which were identical to ratios obtained by difference spectroscopy. Densitometric assays demonstrated that the molar ratio of cyt f/chlorophyll decreased during leaf aging in seven higher plants; however, there was a marked difference in the rate at which cyt f was lost from the leaves of different species ...
A dual-cell device has been designed as an oxidase-like mimic with the oxidation of 3,3′,5,5′-tetramethylbenzidine as a model reaction. This dual-cell device could be also used to study oxidase-like nanozymes. It was found that only the catalytic sites for oxygen reduction are essential and necessary for oxidase-li
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Patented July 28, 1936 PATENT OFFICE COLOR-PHOTOGRAPH) BLEACH OUT DYESTUFF LAYERS Bla Gaspar, Brussels, Belgium No Drawing. Application December 29, 1932, Serial No. 649,442. 1932 7 Claims. This invention relates to a method of producing color-photographic bleach-out dyestufi layers. Attempts to produce color photographic images by bleaching processes are very old, and 5 innumerable variations of this process have been proposed. Very appreciable results have been obtained in this direction, but notwithstanding it has not been possible to make the finished images correspondingly durable. In particular 10 there have been used for this purpose practically without exception basic dyestuffs. Reference is certainly contained in the literature to the effect that on occasion substantive or acid dyestuffs have also been investigated for the-pur- 15 pose in question, thus for example by Valenta in the Photographische Rundschau, 1911, page 56 etc.-, but the results obtained were not of a useful kind, ...
Background: Lipopolysaccharide (LPS), a lipoglycan from the outer membrane of Gram-negative bacteria, is an immunomodulatory molecule that stimulates the innate immune response. High levels of LPS cause excessive release of inflammatory mediators and are responsible for the septic shock syndrome. The interaction of LPS with its cognate binding proteins has not, as yet, been structurally elucidated.,br /,,br /,Results: The X-ray crystallographic structure of LPS in complex with the integralouter membrane protein FhuA from Escherichia coli K-12 is reported. It is in accord with data obtained using mass spectroscopy and nuclear magnetic resonance. Most of the important hydrogen-bonding or electrostatic interactions with LPS are provided by eight positively charged residues of FhuA. Residues in a similar three-dimensional arrangement were searched for in all structurally known proteins using a fast template-matching algorithm, and a subset of four residues was identified that is common to known ...
The most widespread reason behind the illness is the lining up of transitional cells within the bladder. Papillary and nonpapillary (or sessile) tumors grow for that reason. Papillary tumors attach to a stalk and have a wart-like appearance. The latter is far less common but is more obtrusive and has a more extreme outcome. While the exact cause is still doubtful, growth may be due to one or more of the following.. Smoking - Researchers suggest there is a good link between the illness and tobacco use. Nearly half the cases in American males, and a growing number in women, have a relation to cigarette smoke.. Chemical Exposure - Some workplaces may also put you at higher risk for developing the disease. Nearly thirty percent of cases involve people whose occupations regularly expose them to harmful carcinogens like Benzidine and Napthtylamine. Relevant to this cause are concerns dealing with the use of Actos.. Actos bladder ...
본 연구는 학습과 기억에서 중요한 역할을 담당하는 해마형성체(hippocampal formation)와 내후각뇌피질(entorhinal cortex)에서 노화에 따른 세포사 관련물질들의 변화를 비교분석하여, 노화에 따른 중추신경계의 기능적 변화를 유발하는 기전을 추정하는데 필요한 형태학적 기초 자료를 제공하고자 시행되었다. 연구방법은 노화쥐와 대조군에 4% paraformaldehyde를 심장을 통해 관류하여 고정시키고, 뇌를 적출한 후 40μm 두께로 냉동절단하여 면역세포화학 염색을 하였다. NOS, VIP, c-fos bcl-2, bax, p53에 대한 항체를 각각 희석하여 사용하였고 avidin-biotin peroxidase 용액에서 반응시켰다. 그 다음에 peroxidase를 포함한 3,3-diamino benzidine 용액에서 발색시키고 gelatin-coated slide에서 말린 후 광학현미경하에서 관찰하였다. NOS와 bcl-2의 경우는 면역세포화학 염색이 선명하지 않아 in situ ...
United tates Patent 3,232,755 PHOTOCONDUCTIVE LAYERS FOR ELECTRG- PHOTUGRAPHEC PURPOSES Helmut I-ioegl, Wieshaden, Erwin Lind, Wieshaden- Biebrich, and Heinz Schlesinger, lViesbaden, Germany, assignors, by mesne assignments, to Azoplate Corporafion, Murray Hill, N1, a corporation of New Jersey No Drawing. Filed lune 13, 1960, Ser. No. 35,493 Claims priority, application Germany, July 1, 1959, K 38,111 32 Claims. (Cl. 96- 1) Inorganic materials, such as selenium or zinc oxide, as Well as various organic low molecular weight substances, such as anthracene, chrysene, and benzidine, have previously been used for electrophotographie purposes. Photoconductive layers have now been found which are especially suited for electrophotographic usages and which consist, at least partially, of one or more polymerization products or copolymers of heterocycles having vinyl substituents, and/or substitution products thereof. Photoconductive substances suitable for use in the present invention are polymers and ...
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Benzidine, N,N,N,N-tetramethyl-; 4,4-Bis(N,N-dimethylamino)biphenyl; N,N,N,N-Tetramethyl-p,p-benzidine; [1,1-Biphenyl]-4,4-diamine,N,N,N,N-tetramethyl ...
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INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) C. I. DIRECT BLUE 218 NTP Experiment-Test: 05130-03 Report: PEIRPT03 Study Type: CHRONIC Date: 09/17/94 Route: DOSED FEED Time: 01:29:33 Facility: Microbiological Associates Chemical CAS #: 10401-500 Lock Date: 11/21/91 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 05130-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 09/17/94 Route: DOSED FEED Time: 01:29:33 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 0 PPM 1000 PPM 3000 PPM 10000PPM ____________________________________________________________________________________________________________________________________ DISPOSITION ...
Sigma-Aldrich offers abstracts and full-text articles by [Amit Bafana, Sivanesan Saravana Devi, Kannan Krishnamurthi, Tapan Chakrabarti].
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A. Wiebe, B. Riehl, S. Lips, R. Franke, S. R. Waldvogel, Unexpected high robustness of electrochemical cross-coupling for a broad range of current density, Science Advances, 2017, DOI 10.1126/sciadv.aao3920.. M. Hu, K. Korschelt, P. Daniel, K. Landfester, W. Tremel, M. B. Bannwarth, Fibrous nanozyme dressings with catalase-like activity for H2O2 reduction to promote wound healing, ACS Applied Materials & Interfaces, 2017, DOI 10.1021/acsami.7b12212.. M. Shiraiwa, Y. Li, A. P. Tsimpidi, V. A. Karydis, T. Berkemeier, S. N. Pandis, J. Lelieveld, T. Koop, U. Pöschl, "Global distribution of particle phase state in atmospheric secondary organic aerosols", Nature Communications, 2017, 8, Article Number: 15002.. B. Conings, S. A. Bretschneider, A. Babayigit, N. Gauquelin, I. Cardinaletti, J. Manca, J. Verbeeck, H. J. Snaith, H. G. Boyen, " Structure-Property Relations of Methylamine Vapor Treated Hybrid Perovskite CH3NH3PbI3 Films and Solar Cells", ACS Applied Materials & Interfaces, 2017, 9(9), ...
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Wavelength range: 190 to 1,100 nm; 4 nm spectral bandpass. Determination of the color of water and solutions, detection of the presence of dyestuff, quantification of dissolved ions and compounds, etc ...
A photo-sensitive composition for dry formation of image comprising a dyestuff having a photo-fading property, a ketonic sensitizing agent and a high molecular polymer as a binding agent, which can provide a visible image by the irradiation of light and maintain the image without any fixing treatment.
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Glucose oxidase catalyzes the formation of gluconic acid and hydrogen peroxide from the oxidation of glucose. Peroxidase catalyzes the reaction of hydrogen peroxide with a potassium iodide chromogen to oxidize the chromogen to colors ranging from green to brown. Bilirubin couples with diazotized dichloroaniline in a strongly acid medium. Colors range through various shades of tan. Acetoacetic acid reacts with nitroprusside. Colors range from buff-pink, for a negative reading, to maroon for a positive reading. pKa changes occur for certain pretreated polyelectrolytes in relation to ionic concentration. In the presence of an indicator, colors range from deep blue-green in urine of low ionic concentration through green and yellow-green in urines of increasing ionic concentration. Hemoglobin catalyzes the reaction of diisopropylbenzene dihydroperoxide and 3,3,5,5-tetramethylbenzidine. Colors range from orange through green; very high levels of blood may cause the color development to continue to ...
4-Aminobiphenyl exposure can be assayed by measuring the extent of adduct formation with hemoglobin. 4-Aminobiphenyl metabolism is catalyzed by N-hydroxylation via cytochrome P450 1A2. It is then followed by O-sulfation and O-acetylation by sulfotransferase 1A1 and arylamine N-acetyltransferase 2. The urinary metabolites of 4-aminobiphenyl include 4-acetylaminobiphenyl, 4-hydroxy-4-aminobiphenyl, 2-hydroxy-4-acetylaminobiphenyl, 4-hydroxy-4-acetylaminobiphenyl, 3-hydroxy, 4-methoxy-4-acetylaminobiphenyl, 4-hydroxy, 3-methoxy-4-acetylaminobiphenyl, and 3,4-dihydroxy-4-acetylaminobiphenyl. (8, 4 ...
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In the present work, a simple and a sensitive HPLC method was developed for quantitative determination of four Direct textile dyes (Direct Red 81, Direct Blue 15, Direct Black 22 and Direct Orange 34). The maximum absorbance value for the above mentioned dyes were found to be at 510 nm, 607 nm, 484 nm and 411 nm, with retention times of 15.4, 8.8, 5.8 and 12.7 min, respectively. The mobile phase used was consisting of acetonitrile: water (60:40, v/v) containing 0.45 M N-cetyl-N,N,N-trimehyl ammonium bromide (CTAB). RP C18 column was used with a flow rate of 0.5ml/min. Calibration graphs were found to be linear over the ranges of 0.3-10ppm, 10-30ppm, 0.5-10ppm and 1-12ppm for Direct Red 81, Direct Blue 15, Direct Black 22 and Direct Orange 34, respectively, with limit of detection 0.3ppm, 10ppm, 0.5ppm and 1ppm. The relative standard deviations (RSD%) were found to be 0.92 %, 0.83 %, 1.13 % and 0.34 %, respectively (n=3) with concentrations of 10ppm of each dye. The effect of pH, CTAB ...
Investigations were conducted at two chemical facilities that used 3,3-dichlorobenzidine (91941) (DCB) in the production of organic pigments. Requests had been issued for a Health Hazard Evaluation at this site. At each facility the DCB was purchased from suppliers as the dihydrochloride salt in sealed fiber drums. Facility-A performed the DCB charging operation once every other shift in a dedica
Reagents. AdoHcy hydrolase inhibitor DZ2002 was synthesized at Diazyme Laboratories (San Diego, CA). OVA (grade V), dimethyl sulfoxide (DMSO), acetonitrile, AdoHcy, Ado, Hcy, Ado deaminase inhibitor erythro-9-(2-hydroxy-3-nonyl)-adenine hydrochloride, and 3,3′,5,5′-tetramethylbenzidine were supplied by Sigma-Aldrich (St. Louis, MO). Complete Freunds adjuvant (CFA) was purchased from Difco (Detroit, MI). RPMI 1640 medium was purchased from Gibco BRL/Life Technologies Inc. (Gaithersburg, MD), and fetal calf serum (FCS) was obtained from Hyclone Laboratories (Logan, UT). [3H]Thymidine was provided by The Shanghai Institute of Applied Physics, Chinese Academy of Sciences (Shanghai, Peoples Republic of China). ELISA kits for IL-2, IFN-γ, and IL-4 were purchased from BD PharMingen (San Diego, CA). Rabbit anti-mouse IgG, IgG1, IgG2a, or IgG3 antibodies labeled with horseradish peroxidase were purchased from Bio-Rad (Hercules, CA).. Animals. Male C57BL/6 mice, aged 6 to 8 weeks, were purchased ...
TY - JOUR. T1 - Optical biosensor test strip for the screening and direct determination of l-glutamate in food samples. AU - Md Muslim, Noor Zuhartini. AU - Ahmad, Musa. AU - Lee, Yook Heng. AU - Saad, Bahruddin. PY - 2012/1/3. Y1 - 2012/1/3. N2 - An optical glutamate biosensor test strip based on stacked membranes of nafion/sol-gel (bottom layer) and chitosan (uppermost layer) was fabricated on a piece of paper as support to form a test strip. The use of a stacked membrane system allows multiple immobilizations of sensing components directly without any covalent attachment via straight forward procedures. The uppermost membrane consisted of immobilised enzymes l-glutamate oxidase (GLOD) and horseradish peroxidase (HRP), which sensed the presence of l-glutamate and the bottom membrane contained the indicator dye, 3,3′,5,5′- tetramethylbenzidine. The test strip can be used to measure l-glutamate quantitatively by observing a colour change from light green to dark green with increasing ...
The MP Diagnostics HIV-1/2 ELISA 4.0 is an antigen sandwich immunoassay. The wells of the polystyrene microplate strips are coated with recombinant HIV antigens (gp41, gp120, and gp-36) expressed in E.coli. The conjugate is based on a second set of recombinant HIV antigens expressing the same epitopes as the pre-coated antigens, which is conjugated to horseradish peroxidase. Human serum or plasma, are incubated in these coated wells. HIV-1/2 specific antibodies, if present, will bind to the antigens immobilised on the solid phase. After incubation, the wells are thoroughly washed to remove unbound materials and conjugate is added to the wells. The antigens of the conjugate will bind to any antigen-antibody complexes previously formed and excess unbound conjugate are removed by washing. Colourless solutions containing urea peroxide and tetramethylbenzidine are then added to each well. The presence of specific antibodies is indicated by the presence of a blue colour after incubation, which changes ...
A thin film of triphenylamine dimer, N,N′-bis(3-methylphenyl)-N,N′-bis(phenyl)-benzidine (TPD), doped with fac tris(2-phenylpyridine) iridium (Ir(ppy)3) and platinum octaethyl porphine (PtOEP) is char
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PeproTechs TMB sandwich ELISA kits contain the key components required for the quantitative measurement of natural and/or recombinant proteins using TMB substrate
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2-Nitrophenyl-2-acetamido-2-deoxy-a-D-galactopyranoside (min. 99.0% HPLC) - 3,3-Diaminobenzidine tetrahydrochloride - 3,35,5-Tetramethylbenzidin...
Solid non-dusty, porous dyestuff-foams are described of any desired shape and size containing at least one dyestuff, a foaming agent and optionally bonding agents and/or further additives. These foams are useful for preparing dye liquors or printing pastes by sprinkling said foams into water or organic solvents.
A photo-sensitive composition for dry formation of image comprising a dyestuff having a photo-fading property, a ketonic sensitizing agent and a high molecular polymer as a binding agent, which can provide a visible image by the irradiation of light and maintain the image without any fixing treatment.
Human IFN-γ ELISA development kit contains the key components required for the quantitative measurement of natural and/or recombinant
Siden sidst er det blevet til en enkelt som vi mistede ganske hurtigt. Vi kæmper videre. I eftermiddag sejler vi til Tejn og gør klar til TMB.. ...
Tuning and controlling size, shape and surface characteristics of plasmonic gold nanoparticles can help define their photonic, catalytic, and spectroscopic properties, and therefore are crucial for the development of biosensors. This strategy is demonstrated in the present study. Gold nanostars (Au NST) chemically synthesized through a seeding approach exhibited not only Vis-NIR tunable localized surface plasmon resonance (LSPR), but also strong peroxidase-mimicking activity which can catalyse the oxidation of tetramethylbenzidine (TMB) into an oxidized chromogenic product (oxTMB). The catalytic activity of gold nanostars was found to correlate well with their size and LSPR mode, and to be strongly affected by capping ligands (i.e. poly and oligo ethylene glycol, 11-mercaptoundecanoic acid, 4-mercaptobenzoic acid). When capped with molecular binders (i.e. peptides and antibodies), the peroxidase-mimicking activity was suppressed by almost 100% under the examined conditions. However, a gold ...
The presence of Escherichia coli (E. coli) in food and drinking water is a chronic problem worldwide. Protecting food against bacterial contamination and rapid diagnosis of infection require simple and rapid assays for detection of bacterial pathogens, including E. coli O157:H7. Here we report a rapid and novel colorimetric method for detecting E. coli O157:H7. This colorimetric method is based on the catalytic oxidation of the peroxidase substrate 3,3,5,5-tetramethylbenzidine by hydrogen peroxide using 4-mercaptophenylboronic acid-functioned [email protected] nanoparticles adsorbed on the surface of E. coli O157:H7. The assay showed excellent sensitivity both with the naked eye and based on absorbance measurements. The absorbance at 652 nm was proportional to the concentration of E. coli O157:H7 ranging from 7 to 6 × 10(6) cfu mL(-1) with a limit of detection of 7 cfu mL(-1). The total detection time was less than 40 min.
According to two-phase processes multi-color effects are obtained on cellulosic materials, namely conversion effects with reactive and vat dyestuffs on the one hand and discharge resist prints with reactive dyestuffs and, optionally, vat dyestuffs on the other hand, by printing or padding the reactive dyestuff or a mixture of reactive and vat dyestuffs in a weakly acidic medium onto the material, overprinting this material with a neutral paste containing a stable discharging agent of the sulfinic acid series and, if desired, a vat dyestuff, drying the print, contacting the material with an aqueous strongly alkaline liquor, steaming it and finishing the article in known manner, depending on the choice of dyestuffs.
3,3-Diaminobenzidine Tetrahydrochloride hydrate,97%, Contains Up to 10% Water, ACROS Organics™ 5g; Glass bottle 3,3-Diaminobenzidine Tetrahydrochloride...
The Dyestuff (Black Color) for Textile Fibers Market Research Report provides Industry analysis and evaluation of the current & prospective Market Size, Share, Trend and Growth during the study period 2014-2021. Dyestuff (black color) for textile fibers refers to coloring dyestuff used to impart peculiar black color to fabric materials. These dyestuffs are coloring materials used to color various fiber materials which include nylon, acrylic and polyester. Dyestuff has several end-user applications and high demand from textile and automotive industry. It is used to impart color to apparels, fabrics, home textiles, special purpose clothing. Download Free Sample Copy Of this Report : http://www.decisiondatabases.com/contact/download-sample-1788 The reports detailed overview and analysis involves segmentation on the basis of end-user application and product. Product segments global dyestuff (black color) for textile fiber market into nylon, polyester, acrylic and others (including olefin, etc.). ...
Patented July 7, 1953 UNITED smrss PATENT oF-FIcs w H Y m Qfiflfiflftfifff 1:53,. as zerland, assignors to San zerlandsa Swissfirm j ubgnrawilig; T The present invention elatesto new valuable dyestuffs of the anthrapyridone series; A primary object "of" the? present invention is the embodiment of anew group 01f arithrapyri- done dyestuffs characterizedby superior fastness properties, particularly with respect-to fastness tolight and fastness tofulling. This object; as well asother objects whichwill hereinafter appear, is realized bythe present invention, according to" which an anthraquinone compound which corresponds totheiormula .1 wherein X stands for phenyl or alkylphenyl, and Y stands for phenyl or tetrahydronaphthyl, either of which may carry any desiredsubstituent or substituents other than SOlubiliZiIlg groups, such as sulfonic acid or carboxylic acid groups, is heated with .a benzoylacetic acid ester, whereby conversion of the starting compoundfinto the corresponding ...
WinterGreen Research announces that it has a new study on First Responder. Law Enforcement Robot Mobile Platform Systems of Engagement Market. The 2013 study has 587 pages. 206 tables and figures. Worldwide markets are poised to achieve significant growth as platforms of engagement leverage mobile device capability worldwide. Even as the US presence in Iraq and Afghanistan winds down. automated process implemented as mobile platform systems of engagement are being used to fight terrorists and protect human life. These robots are a new core technology in which all governments must invest. Law Enforcement. First Responder. Border Patrol ground robot market growth comes from the device marketing experts inventing a new role as technology poised to be effective at the forefront of fighting terrorism. Markets at $4.5 billion in 2013 reach $12.0 billion by 2019. Growth is based on the adoption of automated process by Law Enforcement. First Responder. Border Patrol organizations worldwide. Th ...
Find and order enzymes and products like this Horseradish Peroxidase Enzyme on www.antibodies-online.cn. 产品编号 ABIN459285.
Enzyme Explorer - Peroxidase Enzymes products. Sigma-Aldrichs peroxidase product is recognized around the world as the industry standard for diagnostic manufacturing and laboratory scale research applications.
Gradient Grade Methanol,Place of Origin:Tianjin China (Mainland) and Other Details of Gradient Grade Methanol,Methanol on Other Chemicals from China (Mainland) - Wuqiang County Huiquan Dyestuff Chemicals Co., Ltd.
4-Aminobiphenyl 92-67-1 Suppliers,provide 4-Aminobiphenyl 92-67-1 product and the products related with China (Mainland) 4-Aminobiphenyl 92-67-1 Henan Tianfu Chemical Co., Ltd. China (Mainland)
Growing demand for 4-Nitro Aniline from the paints and coatings and dye industry is the major factor driving the growth of global 4-Nitro Aniline market
Onestep QuickBlu® TMB Substrate is a solution for the detection of horseradish peroxidase (HRP) that is manufactured as both a ready-to-use solution as well as in a concentrated form. It rapidly produces a blue-colored reaction product which can be read at 370 nm or 655 nm, or at 450 nm when an acidic stop solution is used. QuickBlu® TMB substrates are stable for up to 4 years at 2 - 8°C. Moreover, QuickBlu® TMB substrate sensitivity is excellent when compared to other leading products. QuickBlu® TMB substrates are manufactured to ensure that the lot-to-lot variability is less than 5%. The solution can be concentrated up to 10x for easy transportation. ...
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Alibaba.com offers 584 arginine base products. About 1% of these are blood system agents, 1% are dyestuff intermediates. A wide variety of arginine base options are available to you, such as free samples, paid samples.
A range of substrates is available for the cytochemical staining of peroxidase activity. The most utilized substrates are diaminobenzidine for brownish color, aminoethylcarbazole for reddish reactions and chloronaphthol to give a blue-black product. Thus, in double or triple staining experiments, antigens can be subsequently stained in the same tissue section ...
Supplied Components. • Coated Clear 96 Well Plates. • 5 x Dilution Buffer. • 10 x PBS-T. • Reporting antibody. • Streptavidin-HRP Conjugate. • TMB Substrate. • Stop Solution. • Plate Sealer. Ordering information. ...
Supplied Components. • Coated Clear 96 Well Plates. • 5 x Dilution Buffer. • 10 x PBS-T. • Reporting antibody. • Streptavidin-HRP Conjugate. • TMB Substrate. • Stop Solution. • Plate Sealer. Ordering information ...
Substances, mixtures and exposure circumstances in this list have been classified by the International Agency for Research on Cancer (IARC) as Group 1: The agent (mixture) is carcinogenic to humans. The exposure circumstance entails exposures that are carcinogenic to humans. This category is used when there is sufficient evidence of carcinogenicity in humans. Exceptionally, an agent (mixture) may be placed in this category when evidence of carcinogenicity in humans is less than sufficient but there is sufficient evidence of carcinogenicity in experimental animals and strong evidence in exposed humans that the agent (mixture) acts through a relevant mechanism of carcinogenicity. 2-Naphthylamine Acetaldehyde associated with consumption of alcoholic beverages 4-Aminobiphenyl Aflatoxins Aristolochic acids, and plants containing them Arsenic and inorganic arsenic compounds1 Asbestos Azathioprine Benzene Benzidine, and dyes metabolized to Benzo[a]pyrene Beryllium and beryllium compounds2 Chlornapazine ...
Blue #1 (E133) and Blue #2 (E132): Banned in Norway, Finland, and France, studies have shown them to cause brain cancer and inhibit nerve-cell development. The colors are found in candy, cereal, soda drinks, sports drinks, and pet food.. • Red #3 (E127) and Red #40 (E129): While Red #3 was banned [in the U.S.] in 1990 for topical use, it can still be sold on the market in our foods and beverages. That should make us all red in the face. Red #40 may contain the carcinogenic contaminant p-Cresidine and is thought to cause tumors of the immune system. In the UK, it is not recommended for children, and it is currently banned in many European nations. The dyes are found in fruit cocktails, maraschino cherries, grenadine, cherry pie mix, ice cream, candy, bakery products, and more.. • Yellow #5 (aka Tartazine, E102): Banned in Norway and Austria, it contains the cancer-causing compounds benzidine and 4-aminobiphenyl. Six of the 11 studies on Yellow #5 showed that it caused genotoxicity, a ...
Two materials containing carbazole moieties and exhibiting a high band gap energy, 3,8-di(9H-carbazol-9-yl)-6-phenylphenanthridine (DCzP) and 3,6-di(naphthalene-2-yl)-9-phenyl-9H-carbazole (DNaC), were synthesized via C{single bond}N coupling and Suzuki coupling reactions, respectively. The compound DCzP exhibited blue emission with the CIE coordinates of x = 0.165 and y = 0.136 from the OLED device, ITO(indium-tin oxide)/NPB(N,N′-bis(naphthalene-1-yl)-N,N′-bis(phenyl)benzidine)/DCzP/LiF/Al. The doped device, ITO/2-TNATA(4,4′,4″-Tris(2-naphtylphenyl-phenylamino) triphenyl amine)/NPB/DCzP + Ir(ppy)3/BCP(2,9-Dimethyl-4,7-diphenyl-1,10-phenanthroline)/Alq3(tris(8-hydroxyquinoline)aluminum/LiF/Al, showed bright yellowish-green emission with a maximum luminance of 23,000 cd/m2 when the synthesized DCzP was applied as a host material for the phosphorescent green dopant. From the double layer device, ITO/DNaC/Alq3/LiF/Al, in which DNaC was used as the hole transporting material, the ...
It is essentially a synthetic mineral tanning agent containing matrix of chromium and iron complexes with organic ligands. The preparation process of the product involves reacting hexavalent chromium salt with iron salt in the presence of sulphuric acid and complexing the resulting matrix with organic ligands in the presence of reducing agent, followed by ageing and drying to get the tanning agent in the powder form. The product has potential use as a self-tanning agent to produce fuller leather without any drawn grain appearance. It withstands precipitation upto pH 6.5. The product may also be used as a natural aid for developing various shades based on black and brown, on leathers tanned with this tanning agent by adding non-dye external aids, thereby avoiding the use of carcinogenic benzidine based dyes. The product exhibits around 90-95% exhaustion of both chromium and iron. It is possible to produce leather exhibiting shrinkage temperature upto 115 o C ...
Mazharul Islam Kiron is a textile consultant and researcher on online business promotion. He is working with one European textile machinery company as a country agent. He is also a contributor of Wikipedia. ...
high purity GAA for leather/rubber (factory),Place of Origin:Hebei China (Mainland) and Other Details of high purity GAA for leather/rubber (factory),glacial acetic acid gaa on Organic Acid from China (Mainland) - Wuqiang County Huiquan Dyestuff Chemicals Co., Ltd.
Gellén, Emese and Péter, Zoltán and Emri, Gabriella and Asztalos, László and Remenyik, Éva (2016) Nonmelanoma bőrtumorok kezelési lehetőségei szervtranszplantált betegeknél egy esetismertetés kapcsán. Orvosi Hetilap, 157 (24). pp. 971-976. ISSN 0030-6002 Rencz, Fanni and Brodszky, Valentin and Péntek, Márta and Balogh, Orsolya and Remenyik, Éva and Szegedi, Andrea and Holló, Péter and Kárpáti, Sarolta and Jókai, Hajnalka and Herszényi, Krisztina and Herédi, Emese and Szántó, Sándor and Gulácsi, László (2014) Arthritis psoriaticával társuló középsúlyos és súlyos psoriasis betegségterhe Magyarországon , Disease burden of psoriasis associated with psoriatic arthritis in Hungary. Orvosi Hetilap, 155 (48). pp. 1913-1921. ISSN 0030-6002 Dozsa, A. and Dezső, Balázs and Tóth, Balázs István and Bácsi, Attila and Póliska, Szilárd and Bíró, Tamás and Rühl, Ralph and Remenyik, Éva and Nagy, László (2014) PPARgamma-Mediated and Arachidonic Acid-Dependent ...
Some cationic composite hydrogels based on chitosan (CS) and poly (N-2-aminoethyl acrylamide) (PAEA) covalently cross-linked with glutaraldehyde (GA) were tested as novel sorbents for two dis-azo dyes: Congo Red and Direct Blue 1. Three CS-based composite hydrogels having different molar ratios between the primary amine groups and the cross-linking agent (GA/NH2 = 5.3 and 12.5), the same total concentration of polycations (CPC = 2 wt%) and two molar ratios between polycations (PAEA:CS = 0.25 and 1.2) were used for this study. Pseudo-first order model, pseudo-second order model and the intraparticle diffusion model were used to analyze the experimental data in order to establish the mechanism of adsorption. The adsorption kinetics has been well described by the pseudo-second order model. The effect of temperature on the adsorption of both dyes has been also investigated.
Citation: Ashok Kumar Sundramoorthy †, Sara Mesgari †, Jing Wang †, Raj Kumar ‡, Mahasin Alam Sk. †, Siew Hooi Yeap †, Qing Zhang ‡, Siu Kwan Sze §, Kok Hwa Lim *†, and Mary B. Chan-Park *†, Journal of the Americal Chemical Society, 2013, 135 (15), pp. 5569 - 5581.. Summary: Semiconducting single-walled carbon nanotubes (s-SWNTs) have emerged as a promising class of electronic materials, but the metallic (m)-SWNTs present in all as-synthesized nanotube samples must be removed for many applications. A high selectivity and high yield separation method has remained elusive. A separation process based on selective chemistry appears to be an attractive route since it is usually relatively simple, but more effective chemicals are needed. Here we demonstrate the first example of a new class of dual selective compounds based on polycyclic aromatic azo compounds, specifically Direct Blue 71 (I), for high-purity separation of s-SWNTs at high yield. Highly enriched (93% purity) s-SWNTs ...
Manufacturing a spun-dyed para-aramid filament yarn includes (a) preparing a spin dope comprising a para-aramid polymer, at least one dyestuff and concentrated sulfuric acid, (b) spinning the spin dope through a spinneret to obtain spun filaments, (c) coagulating the spun filaments to obtain coagulated filaments, (d) neutralizing the coagulated filaments to obtain neutralized filaments, (e) washing the neutralized filaments to obtain washed filaments, and (f) drying the washed filaments to obtain dried filaments. In step a) the spin dope includes 17.5 to 18.5% by weight of a para-aramid polymer with respect to the weight of the spin dope, and 4 to 15% by weight of the at least one dyestuff with respect to the weight of the para-aramid polymer plus the at least one dyestuff. In step f) the filaments are hold under a tension in a range from 0.2 to 0.8 cN/dtex.
http://onlinelibrary.wiley.com/doi/10.1 ... 21299/full Abstract Objective Transient monocular blindness (TMB) attacks may occur during straining activities that impede cerebral venous return. Disturbance of cerebral and orbital venous circulation may be involved in TMB. Methods Duplex ultrasonography and Doppler-flow measurement of jugular ...
Schwenecke, H.; Mayer, D. (2005). "Benzidine and Benzidine Derivatives". Ullmann's Encyclopedia of Industrial Chemistry. ... This intermediate undergoes the benzidine rearrangement to afford 3,3'-dichlorobenzidine.[4] ... Because it is structurally similar to benzidine, a known carcinogen, it is believed that it may share a similar mechanism in ...
5) Benzidine. (6) 1,3 butadiene. (7) Carbon tetrachloride. (8) Chloroform. (9) Ethylene oxide. (10) Nitilotriacetic acid. (11) ...
Peroxidase localization in leukocytes has been studied throughout the 20th century using staining agents such as benzidine ... KAPLOW, LS (August 1965). "SIMPLIFIED MYELOPEROXIDASE STAIN USING BENZIDINE DIHYDROCHLORIDE". Blood. 26: 215-9. PMID 14332483. ...
Also in 1945, Dewar devised the then novel notion of a π complex, which he proposed as an intermediate in the benzidine ... Dewar, M. J. S. (1945). "Mechanism of the Benzidine and Related Rearrangements". Nature. 156 (3974): 784. Bibcode:1945Natur.156 ...
Accordingly, the production of benzidine azo dyes was discontinued in the 1980s "in the most important western industrialized ... Azo dyes derived from benzidine are carcinogens; exposure to them has classically been associated with bladder cancer. ...
Chung K-T; Chen S-C; Claxton LD (2006). "Review of the Salmonella typhimurium mutagenicity of benzidine, benzidine analogues, ... Chung K-T; Chen S-C; Wong TY; Li YS; Wei CI; Chou MW (2000). "Mutagenicity studies of benzidine and its analogs: Structure- ... On that evidence, it has been used as a replacement for carcinogenic compounds such as benzidine and o-phenylenediamine. Sigma ... Holland VR; Saunders BC; Rose FL; Walpole AL (1974). "A safer substitute for benzidine in the detection of blood". Tetrahedron ...
A variety of benzidine derivatives are used in dyes and polymers. Research into biphenyl liquid crystal candidates mainly ...
It is positive in the benzidine test and weakly positive in methyl red test. It exhibits clear hemolysis on ovine blood agar ...
It also tests positive for acetoin production, arginine, dihydrolase, benzidine, catalase, hemolysis, and lipase; it tests ...
... particularly in opposing the use of benzidine-based dyes. By the start of the 1980s, membership had fallen to 56,843 due to ...
1904 - A test for the presence of blood by a wet-chemical method using benzidine became known. approx. 1920 - Viennese chemist ...
2-Tolidine can be produced by a benzidine rearrangement from a hydrazine derivative derived from 2-nitrotoluene. (CH3C6H4)2N2H2 ...
Upon treatment with the bis(diazonium) derivative of benzidine, 1-aminonaphthalene-4-sulfonic acid gives Congo red. It is ...
As used by fumigators to detect hydrogen cyanide, copper(II) salt and an aromatic amine such as benzidine is added to the ... sample; as an alternative to benzidine an alternative amine di-(4,4-bis-dimethylaminophenyl) methane can be used. A positive ...
... it is a bifunctional compound derived via the benzidine rearrangement from o-anisidine. o-Dianisidine is a precursor to some ...
Thirty percent of bladder tumors probably result from occupational exposure in the workplace to carcinogens such as benzidine. ...
Hans Schwenecke, Dieter Mayer "Benzidine and Benzidine Derivatives" in Ullmann's Encyclopedia of Industrial Chemistry, 2005, ... 3,3'-Diaminobenzidine (DAB) is an organic compound with the formula (C6H3(NH2)2)2. This derivative of benzidine is a precursor ... An alternate synthesis route involves the diacylation of benzidine with acetic anhydride under basic conditions: (NH2)C6H4C6H4( ...
Other units such as benzidine derivatives, viologens groups and fullerenes, have also been utilized in supramolecular ...
... of the population favoring the benzidine station. However, on addition of trifluoroacetic acid, the benzidine nitrogen atoms ... The same effect is obtained by electrochemical oxidation (forming the benzidine radical ion) and significantly both processes ... one biphenol and one benzidine unit. In solution at room temperature NMR spectroscopy reveals that the bead shuttles at a rate ...
The risk from aromatic amines, particularly benzidine and a-and ß-naphthylamine, was not well-established until the 1950s. In ...
Once of economic significance, Congo red has fallen into disuse as have all benzidine-derived dyes, owing to their carcinogenic ...
The formation of these pigments involves the reaction of diazotized aromatic diamines (derivatives of benzidine) with coupling ...
Mechanism of the benzidine and Wallach rearrangements based on direct observation of dicationic reaction intermediates and ... the benzidine rearrangement and the Hofmann-Martius rearrangement. In the first part of the reaction, two equivalents of acid ...
All progeny of the injected cells could later be discerned by staining for HRP using benzidine substrate or visualized by ...
This car was washed a few days after Del Castillo's disappearance, but it tested positive for blood in luminol and benzidine ...
Benzidines and aromatic amines contain nitrogen atoms inside or attached to benzene-type rings. Benzidines are or were used in ...
Most people are not exposed to benzidine in the environment. Occupational exposure has been associated with increased risk of ... Benzidine is a manufactured chemical that was used to produce dyes. ... Only very small amounts of free benzidine will dissolve in water; benzidine salts can dissolve more readily in water. Benzidine ... What happens to benzidine when it enters the environment?. *Benzidine in the air exists as a vapor or attached to very small ...
In the past, benzidine was used to test for blood. An enzyme in blood causes the oxidation of benzidine to a distinctively blue ... In August 2010 benzidine dyes were included in the U.S. EPAs List of Chemicals of Concern. The manufacture of Benzidine has ... Benzidine has been linked to bladder and pancreatic cancer. Benzidine is prepared in a two step process from nitrobenzene. ... Schwenecke, H.; Mayer, D. (2005). "Benzidine and Benzidine Derivatives". Ullmanns Encyclopedia of Industrial Chemistry. ...
In the environment, benzidine is found in either its ... Benzidine is a manufactured chemical that does not occur ... In the environment, benzidine is found in either its "free" state (as an organic base), or as a salt. Benzidine was used to ... Chemical Classification: Benzidines/Aromatic amines Summary: Benzidine is a manufactured chemical that does not occur naturally ... Benzidine. CAS ID #: 92-87-5. Affected Organ Systems: Hepatic (Liver), Immunological (Immune System), Neurological (Nervous ...
Toxicological profile for Benzidine. Update. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service. ...
Benzidine also has other names, such as 4,4-diphenylenediamine or Fast Corinth Base B (a registered trade name). In the ... Benzidine is a manufactured chemical that does not occur naturally. It is a crystalline (sandy or sugar-like) solid that may be ... Benzidine can enter your body if you breathe air that has small particles of benzidine or dust to which benzidine is attached. ... Benzidine salts can dissolve more easily in water than free benzidine. Only a very small portion of dissolved benzidine will ...
See Also: Toxicological Abbreviations Benzidine (IARC Summary & Evaluation, Supplement7, 1987) Benzidine (IARC Summary & ... BENZIDINE. ICSC. : 0224. (1,1-Biphenyl)-4,4-diamine. 4,4-Diaminobiphenyl. p-Diaminodiphenyl. Biphenyl-4,4-ylenediamine. ...
BENZIDINE. VOL.: 1 (1972) (p. 80) 5. Summary of Data Reported and Evaluation. 5.1 Animal carcinogenicity data. Benzidine is ... The epidemiological studies showed that occupational exposure to commercial benzidine alone was strongly associated with ... and occupational exposure to benzidine.. Subsequent evaluations: Vol. 29 (1982); Suppl. 7 (1987). Last updated: 12 March 1998 ...
Special Occupational Hazard Review for Benzidine-Based Dyes Cdc-pdf. [PDF - 2,943 KB] ... Special Occupational Hazard Review for Benzidine-Based Dyes. ...
The table below is the Annex XVII to REACH and includes all the restrictions adopted in the framework of REACH and the previous legislation, Directive 76/769/EEC. Each entry shows a substance or a group of substances or a substance in a mixture, and the consequent restriction conditions. The latest consolidated version of REACH presents the restrictions adopted until the date of publication. Subsequent changes are included in the amending Commission regulations.. ...
The CSV is a delimited data format that has fields/columns separated by the semicolon character and records/rows separated by newlines. Fields that may contain a special character (semicolon, newline, or double quote), are enclosed in double quotes. For an easier handling, the list of Pre-registered substances is available in four parts ordered by EC number. They contain the same information as the following full list.. ...
... a benzidine dye precursor, a peroxidase enzyme, and an antipyrine compound. The addition of an antipyrine compound to the ... For purposes of the present invention, the term benzidine type dye precursor is meant to include benzidine, tolidine and dye ... Particularly useful dye forming derivatives of benzidine are tetraalkyl benzidines. Also, for purposes of this invention, the ... benzidine and tetramethylbenzidine. Other benzidine dye precursors such as tetraalkylbenzidines described in U.S. Pat. No. ...
Prevention of health hazards from benzidine congener dyes (BCD) is reviewed. The term BCD is defined as commercial preparations ... Preventing Health Hazards From Exposure to Benzidine Congener Dyes Cdc-pdf. [PDF - 3.17 MB] ... Preventing Health Hazards From Exposure to Benzidine Congener Dyes. ... of dyes produced from benzidine (92875), o-tolidine (119937), or o- dianisidine (119904). The similarities among the 82 dyes of ...
Benzidine. CAS No: 92-87-5. NOTE:. (1) Efficacy of Medical Tests has not been evaluated.. (2) NIOSH references include ...
EPA 8270 Benzidines Mix for your research needs. Find product specific information including CAS, MSDS, protocols and ... EPA 8270 Benzidines Mix, certified reference material, TraceCERT®, 2000 μg/mL each component in methanol, ampule of 1 mL ... EPA 8270 Benzidines Mix 2000 μg/mL each component in methanol, analytical standard ...
The author concludes that workers exposed to benzidine based dyes may metabolically convert the dyes to carcinogenic amine. The ... along with results of studies on the metabolism of benzidine and azo compounds, and epidemiological surveys of industries that ... Information about the carcinogenicity of benzidine (92875) in man and in experimental animals is reviewed, ... Metabolic Reduction of Benzidine Azo Dyes to Benzidine and its Metabolites and Their Possible Relationship to Carcinoma of the ...
  • An industrial hygiene survey and preliminary epidemiological investigation of the Young Aniline Works, Inc., (SIC-2865) Baltimore, Maryland, was conducted on February 22, 1973, as part of the NIOSH industry-wide study of the producers and users of benzidine and its salts. (cdc.gov)
  • 3. Pigment yellow 12 ( Benzidine Yellow G-R) Physical, Chemical and Fastness Properties Molecular. (peerflix.com)
  • Commensurate with these results, there are no references on United States-based benzidine production in the latest available edition of SRI's Directory of Chemical Producers (SRI 2000). (cdc.gov)
  • Benzidine (trivial name), also called 1,1'-biphenyl-4,4'-diamine (systematic name), is an organic compound with the formula (C6H4NH2)2. (wikipedia.org)
  • Benzidine, the trivial name for 4,4'-diaminobiphenyl, is the solid organic compound with the formula (C6H4NH2)2. (hmdb.ca)
  • The occurrence of liver and kidney cancer has some biological plausibility based on what is known about the mechanisms of benzidine carcinogenicity (see Section 3.5.2). (cdc.gov)
  • All progeny of the injected cells could later be discerned by staining for HRP using benzidine substrate or visualized by fluorescence microscopy. (wikipedia.org)