Chemicals and DrugsPhenomena and ProcessesTechnology, Industry, Agriculture
BenzidinesAminobiphenyl CompoundsTanningGuaiacolBiotransformationTextile Industry2-Naphthylamine
Benzidines
Very toxic industrial chemicals. They are absorbed through the skin, causing lethal blood, bladder, liver, and kidney damage and are potent, broad-spectrum carcinogens in most species.
Aminobiphenyl Compounds
Biphenyl compounds substituted in any position by one or more amino groups. Permitted are any substituents except fused rings.
Tanning
A process of preserving animal hides by chemical treatment (using vegetable tannins, metallic sulfates, and sulfurized phenol compounds, or syntans) to make them immune to bacterial attack, and subsequent treatments with fats and greases to make them pliable. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Guaiacol
An agent thought to have disinfectant properties and used as an expectorant. (From Martindale, The Extra Pharmacopoeia, 30th ed, p747)
Biotransformation
The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
Textile Industry
The aggregate business enterprise of manufacturing textiles. (From Random House Unabridged Dictionary, 2d ed)
2-Naphthylamine
A naphthalene derivative with carcinogenic action.

Peroxygenase metabolism of N-acetylbenzidine by prostaglandin H synthase. Formation of an N-hydroxylamine. (1/124)

Synthesis of prostaglandin H2 by prostaglandin H synthase (PHS) results in a two-electron oxidation of the enzyme. An active reduced enzyme is regenerated by reducing cofactors, which become oxidized. This report examines the mechanism by which PHS from ram seminal vesicle microsomes catalyzes the oxidation of the reducing cofactor N-acetylbenzidine (ABZ). During the conversion of 0.06 mM ABZ to its final end product, 4'-nitro-4-acetylaminobiphenyl, a new metabolite was observed when 1 mM ascorbic acid was present. Similar results were observed whether 0.2 mM arachidonic acid or 0.5 mM H2O2 was used as the substrate. This metabolite co-eluted with synthetic N'-hydroxy-N-acetylbenzidine (N'HA), but not with N-hydroxy-N-acetylbenzidine. The new metabolite was identified as N'HA by electrospray ionization/MS/MS. N'HA represented as much as 10% of the total radioactivity recovered by high pressure liquid chromatography. When N'HA was substituted for ABZ, PHS metabolized N'HA to 4'-nitro-4-acetylaminobiphenyl. Inhibitor studies demonstrated that metabolism was due to PHS, not cytochrome P-450. The lack of effect of 5,5-dimethyl-1-pyrroline N-oxide, mannitol, and superoxide dismutase suggests the lack of involvement of one-electron transfer reactions and suggests that hydroxyl radicals and superoxide are not sources of oxygen or oxidants. Oxygen uptake studies did not demonstrate a requirement for molecular oxygen. When [18O]H2O2 was used as the substrate, 18O enrichment was observed for 4'-nitro-4-acetylaminobiphenyl, but not for N'HA. A 97% enrichment was observed for one atom of 18O, and a 17 +/- 7% enrichment was observed for two 18O atoms. The rapid exchange of 18O-N'HA with water was suggested to explain the lack of enrichment of N'HA and the low enrichment of two 18O atoms into 4'-nitro-4-acetylaminobiphenyl. Results demonstrate a peroxygenase oxidation of ABZ and N'HA by PHS and suggest a stepwise oxidation of ABZ to N'-hydroxy, 4'-nitroso, and 4'-nitro products.  (+info)

Human and Escherichia coli beta-glucuronidase hydrolysis of glucuronide conjugates of benzidine and 4-aminobiphenyl, and their hydroxy metabolites. (2/124)

Individuals exposed to carcinogenic aromatic amines excrete arylamine N- and O-glucuronide metabolites. This study assessed the susceptibility of selected glucuronides to hydrolysis by human and Escherichia coli beta-glucuronidase. N- or O-glucuronides were prepared with the following aglycones: benzidine, N-acetylbenzidine, N'-hydroxy-N-acetylbenzidine, N-hydroxy-N-acetylbenzidine, N-hydroxy-N,N'-diacetylbenzidine, 3-hydroxy-N,N'-diacetylbenzidine, 3-hydroxy-benzidine, 4-aminobiphenyl, N-hydroxy-4-aminobiphenyl, and N-hydroxy-N-acetyl-4-aminobiphenyl. The (3)H- and (14)C-labeled glucuronides were prepared with human or rat liver microsomes using UDP-glucuronic acid as cosubstrate. Each of the 10 glucuronides (6-12 microM) was incubated at pH 5.5 or 7.0 with either human recombinant (pure) or E. coli (commercial preparation) beta-glucuronidase for 30 min at 37 degrees C. Hydrolysis was measured by HPLC. Reaction conditions were optimized, using the O-glucuronide of N-hydroxy-N,N'-diacetylbenzidine. Both enzymes preferentially hydrolyzed O-glucuronides over N-glucuronides and distinguished between structural isomers. With E. coli beta-glucuronidase at pH 7.0, selectivity was demonstrated by the complete hydrolysis of N-hydroxy-N-acetyl-4-aminobiphenyl O-glucuronide in the presence of N-acetylbenzidine N-glucuronide, which was not hydrolyzed. Metabolism by both enzymes was completely inhibited by the specific beta-glucuronidase inhibitor saccharic acid-1,4-lactone (0.5 mM). The concentration of human beta-glucuronidase necessary to achieve significant hydrolysis of glucuronides was substantially more than the amount of enzyme reported previously to be present in urine under either normal or pathological conditions. The bacterial enzyme may hydrolyze O-glucuronides, but not N-glucuronides, in urine at neutral pH. Thus, the nonenzymatic hydrolysis of N-glucuronides by acidic urine is likely a more important source of free amine than enzymatic hydrolysis.  (+info)

Ultrastructural localization of light-induced lipid peroxides in the rat retina. (3/124)

PURPOSE: Localization of light-induced lipid peroxides in the rat retina at an ultrastructural level as benzidine-reactive substances. METHODS: Long-Evans rats with nondilated pupils were exposed to intense light of 6000 lux for 12 or 24 hours. Control animals were kept under physiological light conditions. Rats with dilated pupils were exposed to a light intensity of 50 lux or 150,000 lux for 1 hour. For ultrastructural localization the enucleated eyes were fixed in a 0.1-M cacodylate buffer (pH 7.4) containing 2% glutaraldehyde for 2 hours. Pieces of the superior part of the central eyecup were incubated overnight with tetramethylbenzidine (TMB; pH 3.0) at 4 degrees C, postfixed with 1.5% OSO4, and embedded for electron microscopy. RESULTS: In animals exposed to intense light, electron-dense structures appeared exclusively throughout the rod outer segments after an irradiation of 6000 lux for 24 hours or 150,000 lux for 1 hour and were absent in animals with nondilated pupils kept at physiological light conditions. Dilation of the pupils leads to the appearance of electron-dense structures after just 1 hour of 50 lux, whereas rats with nondilated pupils withstand even a 12-hour irradiation with 6000 lux. No electron-dense structures were found when no TMB was used in incubation. CONCLUSIONS: The appearance of electron-dense structures in the rod outer segments depends on the incubation with TMB and intensive light exposure of the rat. Dilation of the pupils lowers the threshold for the emergence of electron-dense structures significantly. This strongly supports the view that light-induced lipid peroxides in the rat retina are localized at an ultrastructural level as benzidine-reactive substances. This protocol presents a tool for the generation and ultrastructural localization of lipid peroxides in rat retinas.  (+info)

Glucuronidation of benzidine and its metabolites by cDNA-expressed human UDP-glucuronosyltransferases and pH stability of glucuronides. (4/124)

Although glucuronidation is considered a necessary step in aromatic amine-induced bladder cancer, the specific enzymes involved are not known. This study assessed the capacity of five different human recombinant UDP-glucuronosyltransferases expressed in COS-1 cells to glucuronidate benzidine, its metabolites and 4-aminobiphenyl. [(14)C]UDP-glucuronic acid was used as co-substrate. UGT1A1, UGT1A4 and UGT1A9 each metabolized all of the aromatic amines. UGT1A9 exhibited the highest relative rates of metabolism with preference for the two hydroxamic acids, N-hydroxy-N-acetylbenzidine and N-hydroxy-N,N'-diacetylbenzidine. UGT1A9 metabolized 4-aminobiphenyl approximately 50% faster than benzidine or N-acetylbenzidine. UGT1A4 N-glucuronidated N'-hydroxy- N-acetylbenzidine at the highest relative rate compared with the other transferases. UGT1A6 was effective in metabolizing only four of the eight aromatic amines tested. UGT1A1 demonstrated more extensive metabolism of the hydroxamic acid, N-hydroxy-N,N'-diacetylbenzidine, and the ring oxidation product, 3-OH-N,N'-diacetylbenzidine, than it did for the other six amines. UGT2B7 was the only product of the UGT2 gene family examined and it metabolized all the aromatic amines at similar low relative levels compared with a preferred substrate, 4-OH-estrone. The K(m) values for N-acetylbenzidine metabolism by UGT1A1 and UGT1A4 were 0.37 +/- 0.14 and 1.8 +/- 0.4 mM, respectively. The O-glucuronide of 3-OH-N,N'-diacetylbenzidine was not hydrolyzed during a 24 h 37 degrees C incubation at either pH 5. 5 or 7.4. Likewise, the O-glucuronide of 3-OH-benzidine was stable at pH 7.4, with 52% remaining at pH 5.5 after 24 h. These results suggest the following relative ranking of transferase metabolism: UGT1A9 > UGT1A4 > > UGT2B7 > UGT1A6 approximately UGT1A1. The relative pH stability of O-glucuronides is consistent with a role in detoxification and excretion of aromatic amines, while the acid lability of N-glucuronides is consistent with delivery of these amines to the bladder epithelium for activation, resulting in DNA adducts which may lead to mutations.  (+info)

H(2)O(2) detection from intact mitochondria as a measure for one-electron reduction of dioxygen requires a non-invasive assay system. (5/124)

Evaluation of the existence of superoxide radicals (O*-(2)), the site of generation and conditions required for one-e(-) transfer to oxygen from biological redox systems is a prerequisite for the understanding of the deregulation of O(2) homeostasis leading to oxidative stress. Mitochondria are increasingly considered the major O*-(2) source in a great variety of diseases and the aging process. Contradictory reports on mitochondrial O*-(2) release prompted us to critically investigate frequently used O*-(2) detection methods for their suitability. Due to the impermeability of the external mitochondrial membrane for most constituents of O*-(2) detection systems we decided to follow the stable dismutation product H(2)O(2). This metabolite was earlier shown to readily permeate into the cytosol. With the exception of tetramethylbenzidine none of the chemical reactants indicating the presence of H(2)O(2) by horseradish peroxidase-catalyzed absorbance change were suited due to solubility problems or low extinction coefficients. Tetramethylbenzidine-dependent H(2)O(2) detection was counteracted by rereduction of the dye through e(-) carriers of the respiratory chain. Although the fluorescent dyes scopoletin and homovanillic acid were found to be suited for the detection of mitochondrial H(2)O(2) release, fluorescence change was strongly affected by mitochondrial protein constituents. The present study has resolved this problem by separating the detection system from H(2)O(2)-producing mitochondria.  (+info)

Examination of low-incidence brain tumor responses in F344 rats following chemical exposures in National Toxicology Program carcinogenicity studies. (6/124)

Neoplasms in the brain are uncommon in control Fischer 344 (F344) rats; they occur at a rate of less than 1% in 2-yr toxicity/carcinogenicity studies. Furthermore, only 10 of nearly 500 studies conducted by the National Toxicology Program (NTP) showed any evidence of chemically related neoplastic effects in the brain. Generally, the brain tumor responses were considered equivocal, because the characteristics of potential neurocarcinogenic agents (such as statistically significant increased incidences, decreased latency and/or survival, and demonstration of dose-response relationships) were not observed. A thorough examination, including comparisons with a well-established historical database, is often critical in evaluating rare brain tumors. Chemicals that gave equivocal evidence of brain tumor responses were generally associated with carcinogenicity at other sites, and many chemicals were mutagenic when incubated with metabolic activating enzymes. Other factors that were supportive of the theory that marginal increases in brain tumor incidence were related to chemical exposure were that (a) some of the tumors were malignant, (b) no brain neoplasms were observed in concurrent controls from some studies, and/or (c) brain tumors were also seen following exposure to structurally related chemicals. In 2-yr studies in F344 rats (studies conducted by the NTP), equivocal evidence of carcinogenicity was observed for the following 9 chemicals: isoprene, bromoethane, chloroethane, 3,3'-dimethylbenzidine dihydrochloride, 3,3'-dimethoxybenzidine dihydrochloride, furosemide, C.I. direct blue 15, diphenhydramine hydrochloride, and 1-H-benzotriazole. Glycidol was the only chemical evaluated by the NTP with which there was clear evidence of brain tumor induction in F344 rats. Clarification of the potential neurocarcinogenic risks of chemicals that produce equivocal evidence of a brain tumor response in conventional 2-yr rodent studies may be aided by the use of transgenic mouse models that exhibit genetic alterations that reflect those present in human brain tumors as well as by the use of in utero exposures.  (+info)

A new group of potent inducers of differentiation in murine erythroleukemia cells. (7/124)

This report identifies a group of compounds, polymethylene bisacetamides (acetylated diamines), which are potent inducers of erythroid differentiation in murine erythroleukemia cells. A known inducing agent, N-methylacetamide, was dimerized through varying numbers of methylenes in an attempt to increase the local effective concentration at adjacent target sites. The simple dimer was no more effective than N-methylacetamide alone; introduction of five to eight methylenes between acetamide groups substantially increased the effectiveness of these compounds. The hexamethylene bisacetamide was active between 0.5 mM and 5 mM; the percentage of cells induced and the rate at which they were recruited to differentiation was dependent upon the concentration of inducer within this range. At 5 mM hexamethylene bisacetamide essentially the entire population (greater than 99%) was induced to a pathway of erythroid differentiation which was greater differentiation of the cultured cells than with any inducer yet tested.  (+info)

Hypochlorous acid-mediated activation of N-acetylbenzidine to form N'-(3'-monophospho-deoxyguanosin-8-yl)-N-acetylbenzidine. (8/124)

Hypochlorous acid (HOCl), a chemically reactive oxidant, is an important component of the inflammatory response and may contribute to carcinogenesis. This study assessed the possible activation of N-acetylbenzidine (ABZ) by HOCI to form a specific DNA adduct, N'-(3'-monophospho-deoxyguanosin-8-yl)-N-acetylbenzidine. HOCl was incubated with 0.06 mM 3H-ABZ, and transformation assessed by HPLC. Similar results were observed at pH 5.5 or 7.4. A linear increase in transformation was observed from 0.025 to 0.1 mM HOCl with up to 80% of ABZ changed. Approximately, 2 nmoles of HOCI oxidized 1 nmole of ABZ. N-oxidation products of ABZ metabolism, such as N'-hydroxy-N-acetylbenzidine, were not detected. Oxidation of ABZ was prevented by taurine, DMPO, glutathione, and ascorbic acid, whereas mannitol was without effect. Results are consistent with a radical mechanism. In the presence of 2'-deoxyguanosine 3'-monophosphate (dGp), a new product (dGp-ABZ) was observed. The same adduct was observed with DNA. dGp-ABZ was found to be quite stable (>80% remaining) at 70 degrees C in pH 5.5 (60 min) and 7.4 (240 min). Electrospray mass spectrometry indicated that dGp-ABZ was N'-(3'-monophospho-deoxyguanosin-8-yl)-N-acetylbenzidine, and this was confirmed by NMR. 32P-postlabeling in combination with TLC and HPLC determined that the adduct made by either HOCl or prostaglandin H synthase oxidation of ABZ in the presence of dGp or DNA was dGp-ABZ. Thus, HOCI activates ABZ to form dGp-ABZ and may be responsible for the presence of this adduct in peripheral white blood cells from workers exposed to benzidine. Reaction of ABZ with HOCl provides an easy, convenient method for preparing dGp-ABZ.  (+info)

Tetramethylbenzidine - Gentaur Genprice IncTetramethylbenzidine - Gentaur Genprice Inc
Lab Reagents. Tetramethylbenzidine Laboratories manufactures the tetramethylbenzidine reagents distributed by Genprice. The Tetramethylbenzidine reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. To purchase these products, for the MSDS, Data Sheet, protocol, storage conditions/temperature or for the concentration, please contact Tetramethylbenzidine. Other Tetramethylbenzidine products are available in stock. Specificity: Tetramethylbenzidine Category:. Lab Tools information ...
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An FT-IR spectroscopic investigation of the adsorption of benzidine by sepiolite from Eskisehir (Turkey). - Lancaster EPrintsAn FT-IR spectroscopic investigation of the adsorption of benzidine by sepiolite from Eskisehir (Turkey). - Lancaster EPrints
The adsorption of benzidine by sepiolite obtained from Eskisehir (Turkey) has been studied by Fourier-transform infrared spectroscopy. A deep green colouration results on reaction of benzidine and sepiolite. In the IR spectrum of benzidine treated sepiolite ν(C-N+) vibrational modes of the uni- and di-positive radical cations are observed in addition to vibrational modes of coordinated benzidine. Spectroscopic results indicate that the principle adsorption mechanism for benzidine is coordination to surface hydroxyls from nitrogen lone pairs and to a relatively small extent, formation of radical cations. No physical sorbed species have been detected. It must be noted that the adsorption of benzidine affected the hydroxyl group vibrations of sepiolite.. ...
http://eprints.lancs.ac.uk/22566/
Tetramethylbenzidine 54827-17-7 MSDS, Safety Technical Specifications MSDSTetramethylbenzidine 54827-17-7 MSDS, Safety Technical Specifications MSDS
Tetramethylbenzidine 54827-17-7 MSDS report, Tetramethylbenzidine MSDS safety technical specifications search, Tetramethylbenzidine safety information specifications ect.
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NIOSHTIC-2 Publications Search - 00093824 - Metabolic Reduction of Benzidine Azo Dyes to Benzidine and its Metabolites and...NIOSHTIC-2 Publications Search - 00093824 - Metabolic Reduction of Benzidine Azo Dyes to Benzidine and its Metabolites and...
Information about the carcinogenicity of benzidine (92875) in man and in experimental animals is reviewed, along with results of studies on the metabolism of benzidine and azo compounds, and epidemiological surveys of industries that use azo dyes. The author concludes that workers exposed to benzidine based dyes may metabolically convert the dyes to carcinogenic amine. The number of workers with p
https://www.cdc.gov/niosh/nioshtic-2/00093824.html
Plus itPlus it
The cooxidative metabolism of the urinary bladder carcinogen benzidine was examined using renal inner medullary microsomes. The products of [14C]benzidine metabolism were recovered in the aqueous but not in the organic soluble fraction of reaction mixtures. The reactive metabolites formed during cooxidative metabolism of benzidine bound to DNA and transfer RNA. Cooxidative metabolism of benzidine and subsequent binding to nucleic acids was dependent upon specific fatty acid substrates and was blocked by inhibitors of prostaglandin endoperoxide synthetase. The ratio of the rates of benzidine product formation was approximately 10:3:1 (trichloroacetic acid precipitable:non-trichloroacetic acid precipitable:transfer RNA bound) over a wide range of arachidonic acid concentrations. Cumene hydroperoxide also initiated cooxidative metabolism of benzidine but was less effective than was arachidonic acid. In contrast to arachidonic acid, cumene hydroperoxide-mediated metabolism of benzidine and guaiacol ...
http://cancerres.aacrjournals.org/content/40/8_Part_1/2839
3,3\,5,5\-Tetramethylbenzidine (TMB) | BioExpress
Learn more about 3,3\,5,5\-Tetramethylbenzidine (TMB). We enable science by offering product choice, services, process excellence and our people make it happen.
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US Patent for Enzyme immunoassay with two-part solution of tetramethylbenzidine as chromogen Patent (Patent # 4,503,143 issued...US Patent for Enzyme immunoassay with two-part solution of tetramethylbenzidine as chromogen Patent (Patent # 4,503,143 issued...
Colorimetric detection of bindable substances such as antibodies and antigens using chromogens of improved sensitivity and stability. The chromogens take the form of activated solutions containing tetramethylbenzidine or water soluble derivatives of tetramethylbenzidine. Such chromogens are of particular use in home testing applications for detection of antigens such as human chorionic gonadotropin, human luteinizing hormone, and gonococcus bacteria, as well as the detection of antibodies for these substances.
https://patents.justia.com/patent/4503143
Plus itPlus it
We evaluated the influence of urine pH on the proportion of urinary benzidine (BZ) and N-acetylbenzidine present in the free, unconjugated state and on exfoliated urothelial cell DNA adduct levels in 32 workers exposed to BZ in India. Postworkshift urine pH was inversely correlated with the proportions of BZ (r = -0.78; P , 0.0001) and N-acetylbenzidine (r = -0.67; P , 0.0001) present as free compounds. Furthermore, the average of each subjects pre- and postworkshift urine pH was negatively associated with the predominant urothelial DNA adduct (P = 0.0037, adjusted for urinary BZ and metabolites), which has been shown to cochromatograph with a N-(3-phosphodeoxyguanosin-8-yl)-N-acetylbenzidine adduct standard. Controlling for internal dose, individuals with urine pH , 6 had 10-fold higher DNA adduct levels compared to subjects with urine pH , or = 7. As reported previously, polymorphisms in NAT1, NAT2, and GSTM1 had no impact on DNA adduct levels. This is the first study to demonstrate that ...
http://cebp.aacrjournals.org/content/6/12/1039
Benzidine (IARC Summary & Evaluation, Volume 1, 1972)Benzidine (IARC Summary & Evaluation, Volume 1, 1972)
The epidemiological studies showed that occupational exposure to commercial benzidine alone was strongly associated with bladder cancer. In the same studies, exposure to 2-naphthylamine alone was similarly associated with bladder cancer. A number of case reports from several countries support the relationship between this neoplasm and occupational exposure to benzidine.. Subsequent evaluations: Vol. 29 (1982); Suppl. 7 (1987). ...
http://inchem.org/documents/iarc/vol01/benzidine.html
Identification of the N-acetylcysteine conjugate of benzidine...Identification of the N-acetylcysteine conjugate of benzidine...
Identification of the N-acetylcysteine conjugate of benzidine formed in the peroxidase activation system.: Benzidine is oxidized by the peroxidase/H2O2 system,
https://www.mysciencework.com/publication/show/identification-n-acetylcysteine-conjugate-benzidine-formed-peroxidase-activation-system-03f17431
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Patent US5824491 - Dry reagent test strip comprising benzidine dye precursor and antipyrine ... - Google PatentsPatent US5824491 - Dry reagent test strip comprising benzidine dye precursor and antipyrine ... - Google Patents
A dry reagent test strip for determining the concentration of an analyte in a liquid sample is described. The test strip has a matrix containing reagent detection chemistry, which includes an oxidase enzyme that can utilize the analyte as a substrate forming hydrogen peroxide, a benzidine dye precursor, a peroxidase enzyme, and an antipyrine compound. The addition of an antipyrine compound to the reagent detection chemistry provides a standard concentration graph which is substantially linear in a desired range of analyte concentration. The precision and accuracy of reading the test strip are enhanced.
http://www.google.com/patents/US5824491?dq=mezick
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Microsomal enzyme preparations from dog liver, kidney, and bladder were used to assess the prostaglandin H synthasecatalyzed activation of carcinogenic aromatic amines to bind covalently to proteins and nucleic acids. Benzidine, a urinary bladder carcinogen, bound to protein of bladder transitional epithelial and renal inner and outer medullary microsomes and was dependent upon addition of arachidonic acid, but not upon reduced nicotinamide adenine dinucleotide phosphate. Bladder transitional epithelial microsomes also activated o-dianisidine, 4-aminobiphenyl, and 2-naphthylamine to bind to protein and transfer RNA and benzidine and o-dianisidine to bind DNA. Cosubstrate and inhibitor specificities were consistent with activation by prostaglandin H synthase. Binding of benzidine to protein was not observed with either hepatic or renal cortical microsomes upon addition of arachidonic acid or reduced nicotinamide adenine dinucleotide phosphate.. Prostaglandin H synthase and mixed-function ...
http://cancerres.aacrjournals.org/content/44/5/1893
Metal free MoS<sub>2</sub> 2D sheets as a peroxidase enzyme and visible-light-induced photocatalyst towards detection and...
TY - JOUR. T1 - Metal free MoS2 2D sheets as a peroxidase enzyme and visible-light-induced photocatalyst towards detection and reduction of Cr(vi) ions. AU - Borthakur, Priyakshree. AU - Boruah, Purna K.. AU - Das, Manash R.. AU - Artemkina, Sofya B.. AU - Poltarak, Pavel A.. AU - Fedorov, Vladimir E.. PY - 2018/10/21. Y1 - 2018/10/21. N2 - Two-dimensional molybdenum disulphide (MoS2) sheets were prepared by using simple thermal decomposition method. The synthesized sheets were characterized by different analytical tools including FTIR, XRD, XPS, Raman spectroscopy, HRTEM and FESEM analyses. The synthesized sheets exhibited outstanding peroxidase mimicking activity towards the peroxidase oxidation of chromogenic probe molecule 3,3′,5,5′-tetramethyl benzidine (TMB), producing a blue coloured solution of 3,3′,5,5′-tetramethylbenzidine diimine (TMBDI) in an acidic medium (pH 4). Based on this peroxidase mimicking activity it was utilized for colorimetric determination of toxic Cr(vi) ions ...
https://research.nsu.ru/ru/publications/metal-free-mossub2sub-2d-sheets-as-a-peroxidase-enzyme-and-visibl
Occupational exposure to o-tolidineOccupational exposure to o-tolidine
A method is described for the sampling and analysis of o-tolidine (119937) , based on a method successfully used for benzidine (92875). Air is drawn through a two stage sampler consisting of a high efficiency fiber filter and a silica gel bed which collects o- tolidine and its salts. The filter and sorbent sections of the sampler are transferred to stoppered tubes and the o-tolidine is desorbed. A triethylamine/methyl-alcohol solution is injected into a high pressure liquid chromatograph. Peak readings are obtained and compared with a standard calibration curve. This method can detect 0.15 to 6.5 micrograms of benzidine per sample (3 to 130 micrograms per cubic meter for a 50 liter air sample) using 0.5 milliliters of desorbing solution and a 10 microliter injection into the liquid chromatograph. The authors suggest that the range of detection for o-tolidine should be similar to that for benzidine. The limit of detection for o-tolidine is predicted to be about 0.05 micrograms per sample. - ...
https://stacks.cdc.gov/view/cdc/19418
OPTOELECTRONIC COMPONENT AND USE OF A COPPER COMPLEX AS DOPANT FOR DOPING A LAYER - Patent applicationOPTOELECTRONIC COMPONENT AND USE OF A COPPER COMPLEX AS DOPANT FOR DOPING A LAYER - Patent application
0058] The additional layer 510 may be p-doped. A dopant provided for the additional layer 510 in various working examples is a copper complex. In various working examples, the additional layer 510 is doped with the dopant with a dopant concentration within a range from about 1% to about 20%, for example within a range from about 1% to about 15%, for example within a range from about 2% to about 8%. The following materials may be used as part of the matrix material of the additional layer 110: NPB (N,N-bis(1-naphthyl)-N,N-bis(phenyl)benzidine), β-NPB (N,N-bis(naphthalen-2-yl)-N,N-bis(phenyl)benzidine), TPD (N,N-bis(3-methylphenyl)-N,N-bis(phenyl)benzidine), N,N-bis(1-naphthyl)-N,N-bis(phenyl)-2,2-dimethylbenzidine, spiro-TPD (N,N-bis(3-methylphenyl)-N,N-bis(phenyl)-9,9-spirobifluorene), spiro-NPB (N,N-bis(1-naphthyl)-N,N-bis(phenyl)-9,9-spirobifluorene), DMFL-TPD (N,N-bis(3-methylphenyl)-N,N-bis(phenyl)-9,9-dimethylfluorene, DMFL-NPB ...
http://www.patentsencyclopedia.com/app/20140048785
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Sensors | Free Full-Text | A Simple Assay for Ultrasensitive Colorimetric Detection of Ag+ at Picomolar Levels Using Platinum...Sensors | Free Full-Text | A Simple Assay for Ultrasensitive Colorimetric Detection of Ag+ at Picomolar Levels Using Platinum...
In this work, uniformly-dispersed platinum nanoparticles (PtNPs) were synthesized by a simple chemical reduction method, in which citric acid and sodium borohydride acted as a stabilizer and reducer, respectively. An ultrasensitive colorimetric sensor for the facile and rapid detection of Ag+ ions was constructed based on the peroxidase mimetic activities of the obtained PtNPs, which can catalyze the oxidation of 3,3,5,5-tetramethylbenzidine (TMB) by H2O2 to produce colored products. The introduced Ag+ would be reduced to Ag0 by the capped citric acid, and the deposition of Ag0 on the PtNPs surface, can effectively inhibit the peroxidase-mimetic activity of PtNPs. Through measuring the maximum absorption signal of oxidized TMB at 652 nm, ultra-low detection limits (7.8 pM) of Ag+ can be reached. In addition to such high sensitivity, the colorimetric assay also displays excellent selectivity for other ions of interest and shows great potential for the detection of Ag+ in real water samples.
http://www.mdpi.com/1424-8220/17/11/2521
SeraSpot® Anti-EBV-4 IgG / SeraSpot® Anti-EBV-3 IgM - Clinical DiagnosticsSeraSpot® Anti-EBV-4 IgG / SeraSpot® Anti-EBV-3 IgM - Clinical Diagnostics
The SeraSpot® Anti-EBV-4 IgG / SeraSpot® Anti-EBV-3 IgM test is a solid phase immunoassay based on the use of recombinant EBV antigens as capture antigens printed in array arrangement (spot array) on the bottom of the wells of 96well-microtiter plates. The recombinant antigens serve as capture molecules for antibodies against EBV antigens. Bound antibodies are detected by horseradish peroxidase-(HRP)-labeled antibodies against human antibodies of IgG- or IgM-type by substrate reaction with hydrogen peroxide and 3,3,5,5-tetramethylbenzidine (TMB). At the site of formed immune complexes blue spots are developed by precipitated product from colorless substrate solution. Color intensity correlates to the antibody concentration. Pale blue to dark blue spots are visible by eye ...
https://clinical.r-biopharm.com/products/seraspot-anti-ebv-4-igg-seraspot-anti-ebv-3-igm/
SeraSpot® Anti-Yersinia-6 IgA / IgG - Clinical DiagnosticsSeraSpot® Anti-Yersinia-6 IgA / IgG - Clinical Diagnostics
appendicitis.. Principle:. The SeraSpot® Anti-Yersinia-6 IgG / SeraSpot® Anti-Yersinia-6 IgA test is a solid phase immunoassay based on the use of recombinant Yersinia proteins as capture antigens printed in array arrangement (spot array) on the bottom of the wells of 96-well microtiter plates. The recombinant antigens serve as capture molecules for antibodies against Yersinia antigens. Bound antibodies are detected by horseradish peroxidase-(HRP)-labeled antibodies against human antibodies of IgG- or IgA-type by substrate reaction with hydrogen peroxide and 3,3,5,5-tetramethylbenzidine (TMB). At the site of formed immune complexes blue spots are developed by precipitated product from colorless substrate solution. Color intensity is correlated to the antibody concentration. Pale blue to dark blue spots are visible by eye.. Article No.:. ...
https://clinical.r-biopharm.com/products/seraspot-anti-yersinia-6-iga-igg/
China Dyestuff intermediates Catalog--the Dyestuff intermediates Catalog of China Dyestuff intermediates and China Dyestuff...
China Dyestuff intermediates Catalog is online Dyestuff intermediates database of China Dyestuff intermediates and China Dyestuff intermediates Suppliers.
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Dyestuffs and Pigments Catalog, Dyestuffs and Pigments Products, Dyestuffs and Pigments Suppliers
Dyestuffs and Pigments Catalog with China Dyestuffs and Pigments Products, Dyestuffs and Pigments Suppliers, Dyestuffs and Pigments Manufacturers, and Dyestuffs and Pigments Exporters provided by ChemNet
http://chemnet.com/Global/Products/Dyestuffs-and-Pigments/Directory-1.html
NIOSHTIC-2 Publications Search - 00103469 - Carcinogenicity and metabolism of azo dyes, especially those derived from...NIOSHTIC-2 Publications Search - 00103469 - Carcinogenicity and metabolism of azo dyes, especially those derived from...
The carcinogenicity and metabolism of azo dyes derived from benzidine (92875) is presented. The metabolism of benzidine and azo compounds in humans and animals is discussed, and the disease incidence among workers in industries using azo dyestuffs is described. Industrial hygiene surveys performed to monitor the environment of azo dye workers and their urinary excretion of aromatic amines and benz
https://www.cdc.gov/niosh/nioshtic-2/00103469.html
Research Journal of Chemical Sciences : A Highly Sensitive Spectrophotometric Method for the Micro level Determination of ...Research Journal of Chemical Sciences : A Highly Sensitive Spectrophotometric Method for the Micro level Determination of ...
A simple, sensitive and rapid spectrophotometric method for the determination of anions, nitrite and nitrate has been described. Determination of nitrite is by means of reactions involving tetrazotisation of Benzidine, followed by coupling withN,N-dimethylaniline and determination of nitrate is mainly based on reduction of nitrate to nitrite by using granular Zinc in NaCl. The produced nitrite is then availed to tetrazotize the Benzidine, which is then coupled with N,N-dimethylaniline to form pinkish red colored an azo dye in acidic medium. Measured the absorbance of resulted colored dye solution at 538 nm. Amount of reagents required is optimised and the extent of tolerance limit by the diverse ions was investigated. The Beer-Lambert s linearity range for Benzidine- N,N-dimethylaniline couple was found to be 0.05 to 0.3g/mL of nitrite with molar absorptivity 3.475x10Lmol-1cm-1 and sandell s sensitivity 3.3152x10-4gcm-2. The evaluated detection limit and quantization limit for the determination ...
http://isca.in/rjcs/Archives/v5/i2/8.ISCA-RJCS-2015-012.php
Abstract for TR-92Abstract for TR-92
Hydrazobenzene is a hydrazine derivative selected for bioassay by the National Cancer Institute because of the documented carcinogenicity of the parent compound hydrazine and of certain substituted hydrazines. Treatment of hydrazobenzene with hot mineral acid results in the production of benzidine (the so-called benzidine rearrangement) and hydrazobenzene finds application in the dye manufacturing industry as a precursor of this important dye intermediate and potent carcinogen.. A bioassay of technical-grade hydrazobenzene for possible carcinogenicity was conducted using Fischer 344 rats and B6C3F1 mice. Hydrazobenzene was administered in the feed, at either of two concentrations, to groups of 50 male and 47 to 50 females animals of each species. The time-weighted average dietary concentrations used in the rat bioassay were 0.008, 0.03, 0.004, and 0.01 percent for low dose males, high dose males, low dose females, and high dose females, respectively. The time-weighted average dietary ...
https://ntp.niehs.nih.gov/results/pubs/longterm/reports/longterm/abstracts99/tr092/index.html
Copper,... - Registration Dossier - ECHACopper,... - Registration Dossier - ECHA
The short-term toxicity to aquatic invertebrates has been evaluated taken into account the already existing data on the Direct Blue 199 Na form (i.e. Direct Blue 199_Na). The usage of information on Direct Blue 199_Na, which has the same main component and with a different counter ion, can be considered as suitable and appropriated because the difference in salification is expected to not influence the characteristics related to the specific end-point. The impurity profile does not impact on the read across proposed. Details on the approach followed are included in the document attached to the IUCLID section 13. The acute toxicity of Direct Blue 199_Na to Daphnia magna was determined according to the OECD Guideline 202. The test was carried out under static exposure conditions for a period of 48 hours, at the following concentrations: 1, 10 and 100 mg/l. After 24 and 48 hours of incubation no significant effects (, 10 % of a total of 40 individuals) were observed at all test concentrations and ...
https://echa.europa.eu/registration-dossier/-/registered-dossier/20375/6/2/4
Meghmani Dyes and Intermediates Ltd.公司提供的Megavat Direct Black GV -- 印藝與油墨Meghmani Dyes and Intermediates Ltd.公司提供的Megavat Direct Black GV -- 印藝與油墨
Megavat Direct Black GV is a black vat dye derived from anthraquinone. It is insoluble in water except during the dyeing process. This product comes in ...
https://www.ulprospector.com/zh-tw/asia/Inks/Detail/30156/597053/Megavat-Direct-Black-GV
2,7-Naphthalenedisulfonic acid,... - Registration Dossier - ECHA2,7-Naphthalenedisulfonic acid,... - Registration Dossier - ECHA
Direct Black 168 is a dark organic powder. Direct Black 168 is not toxic/harmful for short-term exposures and it is not skin irritating; however, it is able to cause eye irritation. Direct Black 168 is not a skin sensitizer agent. No CMR activity has never been reported and has been observed in specific experiments performed. No adverse effects were observed during the experiments run, thus, mechanisms of bioactivation leading to adverse effects are not expected to occur at moderate dosages. Specific studies or specific literature data on toxicokinetics and metabolism are not available, thus information about the substance has been taken into account, avoiding further tests. Because of the molecular structure and the hydrophilic of Direct Black 168, dermal absorption is expected to be negligible. Based on the available information, potential dermal toxicity is not suspected. Furthermore, the substance gave negative results in skin sensitisation assay, thus it is considered as not able to cause ...
https://echa.europa.eu/sv/registration-dossier/-/registered-dossier/23551/7/2/1
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China Sodium Nitrate 99.3% Crystalline Application Dye Industry Manufacturers and Suppliers - Factory Price
Buy discount sodium nitrate 99.3% crystalline application dye industry here with our factory which is one of leading Sodium Nitrate 99.3% manufacturers and suppliers in China. We have various famous brands products which are made in China at your choice.
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Polymers | Free Full-Text | Design and Preparation of Nano-Lignin Peroxidase (NanoLiP) by Protein Block Copolymerization...Polymers | Free Full-Text | Design and Preparation of Nano-Lignin Peroxidase (NanoLiP) by Protein Block Copolymerization...
This study describes the preparation of nanoprotein particles having lignin peroxidase (LiP) using a photosensitive microemulsion polymerization technique. The protein-based nano block polymer was synthesized by cross-linking of ligninase enzyme with ruthenium-based aminoacid monomers. This type polymerization process brought stability in different reaction conditions, reusability and functionality to the protein-based nano block polymer system when compared the traditional methods. After characterization of the prepared LiP copolymer nanoparticles, enzymatic activity studies of the nanoenzymes were carried out using tetramethylbenzidine (TMB) as the substrate. The parameters such as pH, temperature and initial enzyme concentration that affect the activity, were investigated by using prepared nanoLip particles and compared to free LiP. The reusability of the nano-LiP particles was also investigated and the obtained results showed that the nano-LiP particles exhibited admirable potential as a reusable
http://www.mdpi.com/2073-4360/8/6/223
HIV - Infectious Disease - DiagnosticsHIV - Infectious Disease - Diagnostics
The MP Diagnostics HIV-1/2 ELISA 4.0 is an antigen sandwich immunoassay. The wells of the polystyrene microplate strips are coated with recombinant HIV antigens (gp41, gp120, and gp-36) expressed in E.coli. The conjugate is based on a second set of recombinant HIV antigens expressing the same epitopes as the pre-coated antigens, which is conjugated to horseradish peroxidase. Human serum or plasma, are incubated in these coated wells. HIV-1/2 specific antibodies, if present, will bind to the antigens immobilised on the solid phase. After incubation, the wells are thoroughly washed to remove unbound materials and conjugate is added to the wells. The antigens of the conjugate will bind to any antigen-antibody complexes previously formed and excess unbound conjugate are removed by washing. Colourless solutions containing urea peroxide and tetramethylbenzidine are then added to each well. The presence of specific antibodies is indicated by the presence of a blue colour after incubation, which changes ...
https://www.mpbio.com/diagnostics/infectious-disease/hiv
Lyme Disease Serology, Spinal Fluid - Seattle Childrens Hospital
This Borrelia burgdorferi (Lyme) assay is based on a synthetic peptide antigen (C6 peptide) in microwell enzyme-linked immunosorbent assay (ELISA) format. The antigen is derived from the vlsE protein of Borrelia burgdorferi. In the assay procedure, diluted cerebrospinal fluid specimens are added and incubated in wells of an antigen-coated microwell plate. Antibodies specific to the C6 peptide in the specimen are bound by the immobilized antigen, and unbound antibodies are removed by wash steps. The bound antibodies are detected by addition of a horseradish peroxidase-conjugated goat antihuman IgG/IgM conjugate. After removal of excess conjugate by further wash steps, a chromogenic peroxidase substrate containing tetramethylbenzidine is added. A blue-green product is produced in wells where antibodies have been bound to the antigen. The color development reaction is quenched by addition of dilute sulfuric acid, after which optical absorbance at 450 nm is measured in each well using an ELISA plate ...
http://seattlechildrenslab.testcatalog.org/show/CSF-Lyme
Measurement of cytochrome f in thylakoids of higher plants using quantitative gel electrophoresis - UQ eSpace
A quantitative method was developed to estimate the concentration of cytochrome (cyt) f in isolated thylakoids, using sodium dodecyl sulfate-polyacrylamide gel electrophoresis followed by staining with a heme-specific reagent containing 3,3′,5,5′-tetramethylbenzidine and hydrogen peroxide. This densitometric technique was at least as sensitive as difference spectroscopy. Analysis of thylakoid preparations by densitometry of stained bands using cyt c as standard gave molar ratios of cyt/chlorophyll which were identical to ratios obtained by difference spectroscopy. Densitometric assays demonstrated that the molar ratio of cyt f/chlorophyll decreased during leaf aging in seven higher plants; however, there was a marked difference in the rate at which cyt f was lost from the leaves of different species ...
https://espace.library.uq.edu.au/view/UQ:400486
A dual-cell device designed as an oxidase mimic and its use for the study of oxidase-like nanozymes - Chemical Communications ...A dual-cell device designed as an oxidase mimic and its use for the study of oxidase-like nanozymes - Chemical Communications ...
A dual-cell device has been designed as an oxidase-like mimic with the oxidation of 3,3′,5,5′-tetramethylbenzidine as a model reaction. This dual-cell device could be also used to study oxidase-like nanozymes. It was found that only the catalytic sites for oxygen reduction are essential and necessary for oxidase-li
http://pubs.rsc.org/en/content/articlelanding/2018/cc/c7cc08992a
Medical Surgical Bladder cancer and cystoscopy #1 - SimpleNursing Members
Bladder cancer most often begins in the urothelial cells that line the inside of the bladder. Factors that increase risk of having bladder cancer include smoking, genetics, and previous exposure to chemo-toxic agents like cytoxan and aromatic amines such as benzidine found in the dye industry. The most common symptom of bladder cancer is blood in the urine (i.e., hematuria).. ...
https://members.simplenursing.com/quiz_bank_question/medical-surgical-bladder-cancer-and-cystoscopy-1/
China Paper Dyestuff: Liquid Basic Yellow O - China Basic Yellow O, Liquid DyestuffChina Paper Dyestuff: Liquid Basic Yellow O - China Basic Yellow O, Liquid Dyestuff
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Dyestuffs Manufacturers, Suppliers & Exporters in IndiaDyestuffs Manufacturers, Suppliers & Exporters in India
Search Indian Dyestuffs Manufacturers and Suppliers Details - Contact to Dyestuffs Exporters in India, Dyestuffs Wholesalers, Dyestuffs Distributors and Traders from India.
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Patent US2049005 - Color-photographic bleach out dyestuff layers - Google PatentsPatent US2049005 - Color-photographic bleach out dyestuff layers - Google Patents
Patented July 28, 1936 PATENT OFFICE COLOR-PHOTOGRAPH) BLEACH OUT DYESTUFF LAYERS Bla Gaspar, Brussels, Belgium No Drawing. Application December 29, 1932, Serial No. 649,442. 1932 7 Claims. This invention relates to a method of producing color-photographic bleach-out dyestufi layers. Attempts to produce color photographic images by bleaching processes are very old, and 5 innumerable variations of this process have been proposed. Very appreciable results have been obtained in this direction, but notwithstanding it has not been possible to make the finished images correspondingly durable. In particular 10 there have been used for this purpose practically without exception basic dyestuffs. Reference is certainly contained in the literature to the effect that on occasion substantive or acid dyestuffs have also been investigated for the-pur- 15 pose in question, thus for example by Valenta in the Photographische Rundschau, 1911, page 56 etc.-, but the results obtained were not of a useful kind, ...
http://www.google.ca/patents/US2049005
Acyl chloride-Chengdu Yuanda Chemical Co.,Ltd.
biphenol;dihydroxybiphenyl;Diaminobenzidine;Biphenyltetramine;Bisphenol F Epoxy Resins;Nitrophthalonitrile;Cyclohexanedione;Cumylphenol;Chlorophthalic anhydride;aminophenoxy hexafluoropropane;Cyclohexylmaleimide;Pyrrolidinecarboxamide;amino hydroxyphenyl hexafluoropropane;cyclohexanediol;Naphthalenediamine;Diaminonaphthalene;Polyarylate Liquid Crystal; Liquid Crystal Polymer;pinacol;trifluoromethyl benzidine;trifluoromethyl biphenyldiamine;Dicyclohexylcarbodiimide;Hydroxybenzophenone;Cholesterol;Cyclohexanetetracarboxylic dianhydride;HPMDA;Hydroxyphenethyl alcohol;Tyrosol;Hydroxyethyl phenol;Tetramethyl biphenol;Benzenetetracarboxylic anhydride;Pyromellitic dianhydride;Benzophenonetetracarboxylic dianhydride;Diamino diphenylsulfone;Methylenedi phenylene bismaleimide;Bismaleimide;Methyl phenyl silicone oil;Benzhydrol; Diphenylcarbinol; Diphenylmethanol;tris(4-aminophenyl)methane;aminophenoxy phenyl propane;Dimethylaminopyridine;Epoxycyclohexylmethyl epoxycyclohexanecarboxylate;Difluorobenzophenone
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A conserved structural motif for lipopolysaccharide recognition by procaryotic and eucaryotic proteinsA conserved structural motif for lipopolysaccharide recognition by procaryotic and eucaryotic proteins
Background: Lipopolysaccharide (LPS), a lipoglycan from the outer membrane of Gram-negative bacteria, is an immunomodulatory molecule that stimulates the innate immune response. High levels of LPS cause excessive release of inflammatory mediators and are responsible for the septic shock syndrome. The interaction of LPS with its cognate binding proteins has not, as yet, been structurally elucidated.,br /,,br /,Results: The X-ray crystallographic structure of LPS in complex with the integralouter membrane protein FhuA from Escherichia coli K-12 is reported. It is in accord with data obtained using mass spectroscopy and nuclear magnetic resonance. Most of the important hydrogen-bonding or electrostatic interactions with LPS are provided by eight positively charged residues of FhuA. Residues in a similar three-dimensional arrangement were searched for in all structurally known proteins using a fast template-matching algorithm, and a subset of four residues was identified that is common to known ...
https://kops.uni-konstanz.de/handle/123456789/8098
Getting the Best Legal Help to Submit an Actos Lawsuit
The most widespread reason behind the illness is the lining up of transitional cells within the bladder. Papillary and nonpapillary (or sessile) tumors grow for that reason. Papillary tumors attach to a stalk and have a wart-like appearance. The latter is far less common but is more obtrusive and has a more extreme outcome. While the exact cause is still doubtful, growth may be due to one or more of the following.. Smoking - Researchers suggest there is a good link between the illness and tobacco use. Nearly half the cases in American males, and a growing number in women, have a relation to cigarette smoke.. Chemical Exposure - Some workplaces may also put you at higher risk for developing the disease. Nearly thirty percent of cases involve people whose occupations regularly expose them to harmful carcinogens like Benzidine and Napthtylamine. Relevant to this cause are concerns dealing with the use of Actos.. Actos bladder ...
http://abccontentboard.com/getting-the-best-legal-help-to-submit-an-actos-lawsuit/
DSpace at EWHA: 노화쥐의 해마형성체와 내후각뇌피질에서 세포사 관련물질들의 변화에 대한 면역세포화학적 연구DSpace at EWHA: 노화쥐의 해마형성체와 내후각뇌피질에서 세포사 관련물질들의 변화에 대한 면역세포화학적 연구
본 연구는 학습과 기억에서 중요한 역할을 담당하는 해마형성체(hippocampal formation)와 내후각뇌피질(entorhinal cortex)에서 노화에 따른 세포사 관련물질들의 변화를 비교분석하여, 노화에 따른 중추신경계의 기능적 변화를 유발하는 기전을 추정하는데 필요한 형태학적 기초 자료를 제공하고자 시행되었다. 연구방법은 노화쥐와 대조군에 4% paraformaldehyde를 심장을 통해 관류하여 고정시키고, 뇌를 적출한 후 40μm 두께로 냉동절단하여 면역세포화학 염색을 하였다. NOS, VIP, c-fos bcl-2, bax, p53에 대한 항체를 각각 희석하여 사용하였고 avidin-biotin peroxidase 용액에서 반응시켰다. 그 다음에 peroxidase를 포함한 3,3-diamino benzidine 용액에서 발색시키고 gelatin-coated slide에서 말린 후 광학현미경하에서 관찰하였다. NOS와 bcl-2의 경우는 면역세포화학 염색이 선명하지 않아 in situ ...
http://dspace.ewha.ac.kr/handle/2015.oak/205795
Electron microscopic visualization of tetramethyl benzidine reaction product on horseradish peroxidase neurohistochemistry<...
TY - JOUR. T1 - Electron microscopic visualization of tetramethyl benzidine reaction product on horseradish peroxidase neurohistochemistry. AU - Sakumoto, T.. AU - Nagai, T.. AU - Kimura, H.. AU - Maeda, T.. PY - 1980. Y1 - 1980. UR - http://www.scopus.com/inward/record.url?scp=0018937029&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0018937029&partnerID=8YFLogxK. M3 - Article. C2 - 7471140. AN - SCOPUS:0018937029. VL - 26. SP - 211. EP - 216. JO - Cellular and Molecular Biology. JF - Cellular and Molecular Biology. SN - 0145-5680. IS - 2. ER - ...
https://kyushu-u.pure.elsevier.com/en/publications/electron-microscopic-visualization-of-tetramethyl-benzidine-react
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Abstract for TR-372Abstract for TR-372
3,3-Dimethoxybenzidine dihydrochloride is an off-white powder with amelting point of 274 degrees C. 3,3-Dimethoxybenzidine is used principally as anintermediate in the production of commercial bisazobiphenyl dyes for coloringtextiles, paper, plastic, rubber, and leather. In the synthesis of thebisazobiphenyl dyes, the amine groups of 3,3-dimethoxybenzidine arechemically linked with other aromatic amines. A small quantity of3,3-dimethoxybenzidine is also used as an intermediate in the production of o-dianisidinediisocyanate, which is used in isocyanate-based adhesive systems and as acomponent of polyurethane elastomers.. 3,3-Dimethoxybenzidine dihydrochloride was evaluated in toxicity andcarcinogenicity studies as part of the National Toxicology ProgramsBenzidine Dye Initiative. This Initiative was designed to evaluate the representativebenzidine congeners and benzidine congener-derived and benzidine-deriveddyes. 3,3-Dimethoxybenzidine dihydrochloride was nominated for study becauseof the ...
https://ntp.niehs.nih.gov/results/pubs/longterm/reports/longterm/tr300399/abstracts/tr372/
lifebridgehealthweightloss.net
Glucose oxidase catalyzes the formation of gluconic acid and hydrogen peroxide from the oxidation of glucose. Peroxidase catalyzes the reaction of hydrogen peroxide with a potassium iodide chromogen to oxidize the chromogen to colors ranging from green to brown. Bilirubin couples with diazotized dichloroaniline in a strongly acid medium. Colors range through various shades of tan. Acetoacetic acid reacts with nitroprusside. Colors range from buff-pink, for a negative reading, to maroon for a positive reading. pKa changes occur for certain pretreated polyelectrolytes in relation to ionic concentration. In the presence of an indicator, colors range from deep blue-green in urine of low ionic concentration through green and yellow-green in urines of increasing ionic concentration. Hemoglobin catalyzes the reaction of diisopropylbenzene dihydroperoxide and 3,3,5,5-tetramethylbenzidine. Colors range from orange through green; very high levels of blood may cause the color development to continue to ...
http://pdfmedfinder.com/l/lifebridgehealthweightloss.net1.html
T3DB: 4-Aminobiphenyl
4-Aminobiphenyl exposure can be assayed by measuring the extent of adduct formation with hemoglobin. 4-Aminobiphenyl metabolism is catalyzed by N-hydroxylation via cytochrome P450 1A2. It is then followed by O-sulfation and O-acetylation by sulfotransferase 1A1 and arylamine N-acetyltransferase 2. The urinary metabolites of 4-aminobiphenyl include 4-acetylaminobiphenyl, 4-hydroxy-4-aminobiphenyl, 2-hydroxy-4-acetylaminobiphenyl, 4-hydroxy-4-acetylaminobiphenyl, 3-hydroxy, 4-methoxy-4-acetylaminobiphenyl, 4-hydroxy, 3-methoxy-4-acetylaminobiphenyl, and 3,4-dihydroxy-4-acetylaminobiphenyl. (8, 4 ...
http://www.t3db.ca/toxins/T3D0232
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HPLC Determination of Four Textile Dyes and Studying Their Degradation Usin | Scientist SolutionsHPLC Determination of Four Textile Dyes and Studying Their Degradation Usin | Scientist Solutions
In the present work, a simple and a sensitive HPLC method was developed for quantitative determination of four Direct textile dyes (Direct Red 81, Direct Blue 15, Direct Black 22 and Direct Orange 34). The maximum absorbance value for the above mentioned dyes were found to be at 510 nm, 607 nm, 484 nm and 411 nm, with retention times of 15.4, 8.8, 5.8 and 12.7 min, respectively. The mobile phase used was consisting of acetonitrile: water (60:40, v/v) containing 0.45 M N-cetyl-N,N,N-trimehyl ammonium bromide (CTAB). RP C18 column was used with a flow rate of 0.5ml/min. Calibration graphs were found to be linear over the ranges of 0.3-10ppm, 10-30ppm, 0.5-10ppm and 1-12ppm for Direct Red 81, Direct Blue 15, Direct Black 22 and Direct Orange 34, respectively, with limit of detection 0.3ppm, 10ppm, 0.5ppm and 1ppm. The relative standard deviations (RSD%) were found to be 0.92 %, 0.83 %, 1.13 % and 0.34 %, respectively (n=3) with concentrations of 10ppm of each dye. The effect of pH, CTAB ...
http://www.scientistsolutions.com/forum/analytical-chemistry-environmental-analysis-wet-chemical/hplc-determination-four-textile-dyes
Plus itPlus it
Reagents. AdoHcy hydrolase inhibitor DZ2002 was synthesized at Diazyme Laboratories (San Diego, CA). OVA (grade V), dimethyl sulfoxide (DMSO), acetonitrile, AdoHcy, Ado, Hcy, Ado deaminase inhibitor erythro-9-(2-hydroxy-3-nonyl)-adenine hydrochloride, and 3,3′,5,5′-tetramethylbenzidine were supplied by Sigma-Aldrich (St. Louis, MO). Complete Freunds adjuvant (CFA) was purchased from Difco (Detroit, MI). RPMI 1640 medium was purchased from Gibco BRL/Life Technologies Inc. (Gaithersburg, MD), and fetal calf serum (FCS) was obtained from Hyclone Laboratories (Logan, UT). [3H]Thymidine was provided by The Shanghai Institute of Applied Physics, Chinese Academy of Sciences (Shanghai, Peoples Republic of China). ELISA kits for IL-2, IFN-γ, and IL-4 were purchased from BD PharMingen (San Diego, CA). Rabbit anti-mouse IgG, IgG1, IgG2a, or IgG3 antibodies labeled with horseradish peroxidase were purchased from Bio-Rad (Hercules, CA).. Animals. Male C57BL/6 mice, aged 6 to 8 weeks, were purchased ...
http://jpet.aspetjournals.org/content/316/3/1229
Optical biosensor test strip for the screening and direct determination of l-glutamate in food samples<...
TY - JOUR. T1 - Optical biosensor test strip for the screening and direct determination of l-glutamate in food samples. AU - Md Muslim, Noor Zuhartini. AU - Ahmad, Musa. AU - Lee, Yook Heng. AU - Saad, Bahruddin. PY - 2012/1/3. Y1 - 2012/1/3. N2 - An optical glutamate biosensor test strip based on stacked membranes of nafion/sol-gel (bottom layer) and chitosan (uppermost layer) was fabricated on a piece of paper as support to form a test strip. The use of a stacked membrane system allows multiple immobilizations of sensing components directly without any covalent attachment via straight forward procedures. The uppermost membrane consisted of immobilised enzymes l-glutamate oxidase (GLOD) and horseradish peroxidase (HRP), which sensed the presence of l-glutamate and the bottom membrane contained the indicator dye, 3,3′,5,5′- tetramethylbenzidine. The test strip can be used to measure l-glutamate quantitatively by observing a colour change from light green to dark green with increasing ...
https://ukm.pure.elsevier.com/en/publications/optical-biosensor-test-strip-for-the-screening-and-direct-determi
Enzyme Immunoassay (EIA/ELISA), Echinococcus granulosus
The MP Diagnostics HIV-1/2 ELISA 4.0 is an antigen sandwich immunoassay. The wells of the polystyrene microplate strips are coated with recombinant HIV antigens (gp41, gp120, and gp-36) expressed in E.coli. The conjugate is based on a second set of recombinant HIV antigens expressing the same epitopes as the pre-coated antigens, which is conjugated to horseradish peroxidase. Human serum or plasma, are incubated in these coated wells. HIV-1/2 specific antibodies, if present, will bind to the antigens immobilised on the solid phase. After incubation, the wells are thoroughly washed to remove unbound materials and conjugate is added to the wells. The antigens of the conjugate will bind to any antigen-antibody complexes previously formed and excess unbound conjugate are removed by washing. Colourless solutions containing urea peroxide and tetramethylbenzidine are then added to each well. The presence of specific antibodies is indicated by the presence of a blue colour after incubation, which changes ...
https://au.mpbio.com/diagnostics/infectious-disease/enzyme-immunoassay-eia-elisa/disease_screened_slr:echinococcus_granulosus
Medullary projections of rabbit carotid sinus nerve<...
TY - JOUR. T1 - Medullary projections of rabbit carotid sinus nerve. AU - Blessing, W. W.. AU - Yu, Y. H.. AU - Nalivaiko, E.. PY - 1999/1/23. Y1 - 1999/1/23. N2 - In New Zealand white rabbits, cholera-toxin HRP was injected into the carotid sinus nerve just proximal to the carotid sinus. After survival periods of 3-5 days the rabbits were anesthetized and the brain fixed with aldehyde solution. Transverse sections were cut on a sledge microtome and the sections reacted with the tetramethylbenzidine procedure. HRP-positive fibers entered the ipsilateral dorsolateral medulla at the level of the acoustic tubercle, joining the tractus Solitarius. Positive fibres were found principally ipsilaterally in four regions of the medulla: in the caudal two thirds of the nucleus tractus solitarius, in its dorsolateral regions and, more caudally, in its commissural subdivision; in the dorsolateral aspect of the spinal nucleus of the trigeminal nerve; in the region ventral and ventrolateral to the tractus ...
https://researchnow.flinders.edu.au/en/publications/medullary-projections-of-rabbit-carotid-sinus-nerve
US20200269196A1 - Aromatic co-polyimide gas separation membranes derived from 6fda-dam-type homo-polyimides - Google...
Co-polyimide membranes for separating components of sour natural gas including at least three distinct moieties polymerized together, the moieties including a 2,2′-bis(3,4-dicarboxyphenyl)hexafluoropropane dianhydride (6FDA) based moiety; a 2,4,6-trimethyl-m-phenylenediamine (DAM) based moiety; and at least one component selected from the group consisting of: a 4,4′-(hexafluoroisopropylidene)dianiline (6FpDA) based moiety; a 9,9-bis(4-aminophenyl) fluorene (CARDO) based moiety; a 2,3,5,6-tetramethyl-1,4-phenylenediamine (durene diamine) based moiety; a 2,2′-bis(trifluoromethyl)benzidine (ABL-21) based moiety; a 3,3′-dihydroxybenzidine based moiety; and a 3,3′-(hexafluoroisopropylidene)dianiline based moiety.
https://patents.google.com/patent/US20200269196A1/en
Energy transfer in a thin film of TPD fluorescent molecules doped with PtOEP and Ir(ppy)3phosphorescent molecules | SpringerLinkEnergy transfer in a thin film of TPD fluorescent molecules doped with PtOEP and Ir(ppy)3phosphorescent molecules | SpringerLink
A thin film of triphenylamine dimer, N,N′-bis(3-methylphenyl)-N,N′-bis(phenyl)-benzidine (TPD), doped with fac tris(2-phenylpyridine) iridium (Ir(ppy)3) and platinum octaethyl porphine (PtOEP) is char
https://link.springer.com/article/10.1007%2Fs00340-005-1850-1
Dyestuff Intermediates - Suppliers, Manufacturers, Exporters Directory - ID 1079
Find Dyestuffs, Dyestuff Intermediates Suppliers, Manufacturers and Exporters full information in Wtleads Comprehensive Directory.
http://www.wtleads.com/buyers-suppliers/Dyestuff-Intermediates_c1079/
Research in the Dye Industry | ScienceResearch in the Dye Industry | Science
Thank you for your interest in spreading the word about Science.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
https://science.sciencemag.org/content/59/1514/11.1
Dyestuff Market in India 2011Dyestuff Market in India 2011
India is considered to be ranked 6th globally in terms of chemical industry volumes. Dyestuff market is under strict environmental regulations which are
https://marketpublishers.com/report/industry/chemicals_petrochemicals/dyestuff_market_in_india_2011.html
Methyl Crotonate,Crotonic Acid,The blue cyanine B,High-light|High-wash|Solvent Dyestuff & Disperse Dyestuff-Highdee
ZhejiangHighdeeChemistryCo.,Ltd,is an old branded facturing enterprise with over 40years experienc, and provides many products such as Methyl Crotonate,Crotonic Acid,Disperse Dyestuff and etc.
http://www.newhighdee.com/?para=en_2_51_39
The Worlds Most Polluting Industries - WorldAtlasThe Worlds Most Polluting Industries - WorldAtlas
Learn about the 10 most polluting industries including the dye industry, mining and ore processing, lead smelting, tanneries, and more.
https://www.worldatlas.com/articles/the-top-10-polluting-industries-in-the-world.html
TMB ELISA KitsTMB ELISA Kits
PeproTechs TMB sandwich ELISA kits contain the key components required for the quantitative measurement of natural and/or recombinant proteins using TMB substrate
https://www.peprotech.com/en/tmb-elisa-kits
尋找可應用於]食品、飲料與營養保健品行業的Changmao Biochemical Engineering Co., Ltd - Vidhi Dyestuffs Mfg. Ltd - AlzChem Shanghai Co. Ltd. - Solvay...尋找可應用於]食品、飲料與營養保健品行業的Changmao Biochemical Engineering Co., Ltd - Vidhi Dyestuffs Mfg. Ltd - AlzChem Shanghai Co. Ltd. - Solvay...
食品、飲料與營養保健品 (Changmao Biochemical Engineering Co., Ltd) | 食品、飲料與營養保健品一站式進行配方，數據表，物質安全數據表搜索，產品特性和樣品申請 -- 免費使用
https://www.ulprospector.com/zh-tw/asia/Food/Suppliers/17219/15683/11982/14570/12359
Gentaur Molecular :Arbor \ TMB Substrate, 5ML \ X019-5MLGentaur Molecular :Arbor \ TMB Substrate, 5ML \ X019-5ML
Gentaur molecular products has all kinds of products like :search , Arbor \ TMB Substrate, 5ML \ X019-5ML for more molecular products just contact us
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Gentaur Molecular :Arbor \ TMB Substrate, 75ML \ X019-75MLGentaur Molecular :Arbor \ TMB Substrate, 75ML \ X019-75ML
Gentaur molecular products has all kinds of products like :search , Arbor \ TMB Substrate, 75ML \ X019-75ML for more molecular products just contact us
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Surmodics - DABI - DAB Immunohistochemistry SubstrateSurmodics - DABI - DAB Immunohistochemistry Substrate
3,3-diaminobenzidine (DAB) is oxidized in the presence of peroxidase and hydrogen peroxide resulting in the deposition of a brown, alcohol-insoluble precipitate at the site of enzymatic activity.
https://shop.surmodics.com/dab-immunohistochemistry-substrate-dabi-0100-2c
SubstratesSubstrates
2-Nitrophenyl-2-acetamido-2-deoxy-a-D-galactopyranoside (min. 99.0% HPLC) - 3,3-Diaminobenzidine tetrahydrochloride - 3,35,5-Tetramethylbenzidin...
https://www.genaxxon.com/shop/en/shop-all-products/biochemicals/substrates/
Brevet US3967921 - Solid, non-dusty dyestuff-foams of any desired shape and size - Google BrevetsBrevet US3967921 - Solid, non-dusty dyestuff-foams of any desired shape and size - Google Brevets
Solid non-dusty, porous dyestuff-foams are described of any desired shape and size containing at least one dyestuff, a foaming agent and optionally bonding agents and/or further additives. These foams are useful for preparing dye liquors or printing pastes by sprinkling said foams into water or organic solvents.
http://www.google.fr/patents/US3967921?hl=fr
Patent US4251622 - Photo-sensitive composition for dry formation of image - Google PatentsPatent US4251622 - Photo-sensitive composition for dry formation of image - Google Patents
A photo-sensitive composition for dry formation of image comprising a dyestuff having a photo-fading property, a ketonic sensitizing agent and a high molecular polymer as a binding agent, which can provide a visible image by the irradiation of light and maintain the image without any fixing treatment.
http://www.google.ca/patents/US4251622
PeproTech. Human IFN-γ Mini TMB ELISA Development KitPeproTech. Human IFN-γ Mini TMB ELISA Development Kit
Human IFN-γ ELISA development kit contains the key components required for the quantitative measurement of natural and/or recombinant
https://www.peprotech.com/human-ifn-mini-tmb-elisa-development-kit
0 Comments
Siden sidst er det blevet til en enkelt som vi mistede ganske hurtigt. Vi kæmper videre. I eftermiddag sejler vi til Tejn og gør klar til TMB.. ...
http://www.teamvertigo.dk/forside/status5
BenzidineBenzidine
In the past, benzidine was used to test for blood. An enzyme in blood causes the oxidation of benzidine to a distinctively blue ... In August 2010 benzidine dyes were included in the U.S. EPA's List of Chemicals of Concern. The manufacture of Benzidine has ... Benzidine has been linked to bladder and pancreatic cancer. Benzidine is prepared in a two step process from nitrobenzene. ... Schwenecke, H.; Mayer, D. (2005). "Benzidine and Benzidine Derivatives". Ullmann's Encyclopedia of Industrial Chemistry. ...
https://en.wikipedia.org/wiki/Benzidine
ChronoamperometryChronoamperometry
The Benzidine Rearrangement1". J. Phys. Chem. 69: 30-40. doi:10.1021/j100885a008. (CS1 errors: missing title, Electroanalytical ...
https://en.wikipedia.org/wiki/Chronoamperometry
3,3-Dichlorobenzidine3,3'-Dichlorobenzidine
Schwenecke, H.; Mayer, D. (2005). "Benzidine and Benzidine Derivatives". Ullmann's Encyclopedia of Industrial Chemistry. ... Because it is structurally similar to benzidine, a known carcinogen, it is believed that it may share a similar mechanism in ... This intermediate undergoes the benzidine rearrangement to afford 3,3'-dichlorobenzidine. Aqueous solutions of 3,3'- ...
https://en.wikipedia.org/wiki/3,3'-Dichlorobenzidine
CyanideCyanide
Schwenecke, H.; Mayer, D. (2005). "Benzidine and Benzidine Derivatives". Ullmann's Encyclopedia of Industrial Chemistry. ... Benzidine gives a blue coloration in the presence of ferricyanide. Iron(II) sulfate added to a solution of cyanide, such as the ...
https://en.wikipedia.org/wiki/Cyanide
Michael J. S. DewarMichael J. S. Dewar
Also in 1945, Dewar devised the then novel notion of a π complex, which he proposed as an intermediate in the benzidine ... Dewar, M. J. S. (1945). "Mechanism of the Benzidine and Related Rearrangements". Nature. 156 (3974): 784. Bibcode:1945Natur.156 ...
https://en.wikipedia.org/wiki/Michael_J._S._Dewar
Azo dyeAzo dye
Accordingly, the production of benzidine azo dyes was discontinued in the 1980s in many western countries. Certain azo dyes ... Azo dyes derived from benzidine are carcinogens; exposure to them has classically been associated with bladder cancer. ...
https://en.wikipedia.org/wiki/Azo_dye
Eosinophil peroxidaseEosinophil peroxidase
Peroxidase localization in leukocytes has been studied throughout the 20th century using staining agents such as benzidine ... Kaplow LS (August 1965). "Brief Report: Simplified Myeloperoxidase Stain Using Benzidine Dihydrochloride". Blood. 26 (2): 215-9 ...
https://en.wikipedia.org/wiki/Eosinophil_peroxidase
Pittsburgh compound BPittsburgh compound B
Cerniglia CE, Freeman JP, Franklin W, Pack LD (1982). "Metabolism of benzidine and benzidine-congener based dyes by human, ... "Summary of the National Toxicology Program benzidine dye initiative". Environ Health Perspect. 102 (supp 2): 63-78. doi:10.1289 ...
https://en.wikipedia.org/wiki/Pittsburgh_compound_B
3,3,5,5-Tetramethylbenzidine3,3',5,5'-Tetramethylbenzidine
Chung K-T; Chen S-C; Claxton LD (2006). "Review of the Salmonella typhimurium mutagenicity of benzidine, benzidine analogues, ... Chung K-T; Chen S-C; Wong TY; Li YS; Wei CI; Chou MW (2000). "Mutagenicity studies of benzidine and its analogs: Structure- ... On that evidence, it has been used as a replacement for carcinogenic compounds such as benzidine and o-phenylenediamine. Sigma ... "TMB Substrate Solution". Holland VR; Saunders BC; Rose FL; Walpole AL (1974). "A safer substitute for benzidine in the ...
https://en.wikipedia.org/wiki/3,3',5,5'-Tetramethylbenzidine
BiphenylBiphenyl
A variety of benzidine derivatives are used in dyes and polymers. Research into biphenyl liquid crystal candidates mainly ...
https://en.wikipedia.org/wiki/Biphenyl
Staphylococcus muscaeStaphylococcus muscae
It is positive in the benzidine test and weakly positive in methyl red test. It exhibits clear hemolysis on ovine blood agar ...
https://en.wikipedia.org/wiki/Staphylococcus_muscae
Staphylococcus haemolyticusStaphylococcus haemolyticus
It also tests positive for acetoin production, arginine, dihydrolase, benzidine, catalase, hemolysis, and lipase; it tests ...
https://en.wikipedia.org/wiki/Staphylococcus_haemolyticus
Supramolecular chemistrySupramolecular chemistry
Other units, such as benzidine derivatives, viologens, and fullerenes, are useful in supramolecular electrochemical devices. ...
https://en.wikipedia.org/wiki/Supramolecular_chemistry
Congo redCongo red
It is prepared by azo coupling of the bis(diazonium) derivative of benzidine with naphthionic acid. Congo blue, however, is in ... Once of economic significance, Congo red has fallen into disuse as have all benzidine-derived dyes, owing to their carcinogenic ...
https://en.wikipedia.org/wiki/Congo_red
4,4-Methylenebis(2-chloroaniline)4,4'-Methylenebis(2-chloroaniline)
MOCA is an aromatic amine which is structurally similar to benzidine, a known human bladder carcinogen. MOCA has been shown to ...
https://en.wikipedia.org/wiki/4,4'-Methylenebis(2-chloroaniline)
Acid dyeAcid dye
Prival, M. J.; Bell, S. J.; Mitchell, V. D.; Peiperl, M. D.; Vaughan, V. L. (1984). "Mutagenicity of benzidine and benzidine- ...
https://en.wikipedia.org/wiki/Acid_dye
Organic peroxidesOrganic peroxides
Quantum chemical calculations predict that it undergoes a nearly barrierless reaction akin to the benzidine rearrangement. The ...
https://en.wikipedia.org/wiki/Organic_peroxides
National Union of Dyers, Bleachers and Textile WorkersNational Union of Dyers, Bleachers and Textile Workers
... particularly in opposing the use of benzidine-based dyes. By the start of the 1980s, membership had fallen to 56,843 due to ...
https://en.wikipedia.org/wiki/National_Union_of_Dyers,_Bleachers_and_Textile_Workers
Urine test stripUrine test strip
1904 - A test for the presence of blood by a wet-chemical method using benzidine became known. approx. 1920 - Viennese chemist ...
https://en.wikipedia.org/wiki/Urine_test_strip
TolidineTolidine
2-Tolidine can be produced by a benzidine rearrangement from a hydrazine derivative derived from 2-nitrotoluene. (CH3C6H4)2N2H2 ...
https://en.wikipedia.org/wiki/Tolidine
1-Naphthylamine1-Naphthylamine
Upon treatment with the bis(diazonium) derivative of benzidine, 1-aminonaphthalene-4-sulfonic acid gives Congo red. It is ...
https://en.wikipedia.org/wiki/1-Naphthylamine
O-DianisidineO-Dianisidine
... it is a bifunctional compound derived via the benzidine rearrangement from o-anisidine. o-Dianisidine is a precursor to some ...
https://en.wikipedia.org/wiki/O-Dianisidine
UGT2B7UGT2B7
One study found that Han Chinese dye-industry workers exposed to benzidine were at higher risk for developing bladder cancer if ... The speculated mechanism for this increased cancer risk involved increased glucuronidation of benzidine by the mutant UGT2B7 ... followed by cleavage of the glucuronidated benzidine at urine pH levels, releasing higher concentrations of benzidine in the ... polymorphism with bladder cancer in benzidine-exposed workers in China". Toxicological Sciences. 85 (1): 502-6. doi:10.1093/ ...
https://en.wikipedia.org/wiki/UGT2B7
3,3-Diaminobenzidine3,3'-Diaminobenzidine
Hans Schwenecke, Dieter Mayer "Benzidine and Benzidine Derivatives" in Ullmann's Encyclopedia of Industrial Chemistry, 2005, ... 3,3′-Diaminobenzidine (DAB) is an organic compound with the formula (C6H3(NH2)2)2. This derivative of benzidine is a precursor ... An alternate synthesis route involves the diacylation of benzidine with acetic anhydride under basic conditions: (NH2)C6H4C6H4( ...
https://en.wikipedia.org/wiki/3,3'-Diaminobenzidine
Molecular switchMolecular switch
... of the population favoring the benzidine station. However, on addition of trifluoroacetic acid, the benzidine nitrogen atoms ... The same effect is obtained by electrochemical oxidation (forming the benzidine radical ion) and significantly both processes ... one biphenol and one benzidine unit. In solution at room temperature NMR spectroscopy reveals that the bead shuttles at a rate ...
https://en.wikipedia.org/wiki/Molecular_switch
Ludwig RehnLudwig Rehn
The risk from aromatic amines, particularly benzidine and a-and ß-naphthylamine, was not well-established until the 1950s. In ...
https://en.wikipedia.org/wiki/Ludwig_Rehn
Diarylide pigmentDiarylide pigment
The formation of these pigments involves the reaction of diazotized aromatic diamines (derivatives of benzidine) with coupling ...
https://en.wikipedia.org/wiki/Diarylide_pigment
Wallach rearrangementWallach rearrangement
Mechanism of the benzidine and Wallach rearrangements based on direct observation of dicationic reaction intermediates and ... the benzidine rearrangement and the Hofmann-Martius rearrangement. In the first part of the reaction, two equivalents of acid ...
https://en.wikipedia.org/wiki/Wallach_rearrangement
Murder of Marta del CastilloMurder of Marta del Castillo
This car was washed a few days after Del Castillo's disappearance, but it tested positive for blood in luminol and benzidine ...
https://en.wikipedia.org/wiki/Murder_of_Marta_del_Castillo
Glucose meterGlucose meter
Besides glucose oxidase, the test kit contains a benzidine derivative, which is oxidized to a blue polymer by the hydrogen ...
https://en.wikipedia.org/wiki/Glucose_meter
Benzidine | Toxicological Profile | ATSDR
Toxicological profile for Benzidine. Update. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service. ...
https://wwwn.cdc.gov/tsp/ToxProfiles/ToxProfiles.aspx?id=569&tid=105
Benzidine (2005-110) | NIOSH | CDCBenzidine (2005-110) | NIOSH | CDC
Benzidine. CAS No: 92-87-5. NOTE:. (1) Efficacy of Medical Tests has not been evaluated.. (2) NIOSH references include ... Benzidine. Editor(s). /Author(s). Specific Medical Test(s) or Examination(s). Reference(s). ...
https://www.cdc.gov/niosh/docs/2005-110/nmed0023.html
benzidine hydrochloride | Semantic Scholarbenzidine hydrochloride | Semantic Scholar
The use of benzidine hydrochloride to precipitate sulfates as insoluble benzidine sulfate was first proposed by Miiller (1902… ... A new method is used for the rapid determination of SO2-4 in laboratory waste water by benzidine hydrochloride separate and ... THE chief difficulties in the benzidine method for determination of sulphate arise in obtaining the conditions requisite for… ... Study on the Determination of Sulfate in Laboratory Waste Water by Benzidine Hydrochloride Separate and Acid-Base Titration ...
https://www.semanticscholar.org/topic/benzidine-hydrochloride/2832413
Certain Monoazo pigments of the Aromatic Azo and Benzidine-based substance grouping - Canada.caCertain Monoazo pigments of the Aromatic Azo and Benzidine-based substance grouping - Canada.ca
Certain Monoazo pigments of the Aromatic Azo and Benzidine-based substance grouping. What are they?. *Thirty-three substances ... to be published once assessment for all of the Aromatic Azo and Benzidine-based Substance Grouping are completed. ...
https://www.canada.ca/en/health-canada/services/chemical-substances/fact-sheets/chemicals-glance/certain-monoazo-pigments-aromatic-benzidine-based-substance-grouping.html
Cooxidation of benzidine by renal medullary prostaglandin cyclooxygenase. | Journal of Pharmacology and Experimental...Cooxidation of benzidine by renal medullary prostaglandin cyclooxygenase. | Journal of Pharmacology and Experimental...
Cooxidation of benzidine by renal medullary prostaglandin cyclooxygenase.. T V Zenser, M B Mattammal and B B Davis ... Cooxidation of benzidine by renal medullary prostaglandin cyclooxygenase.. T V Zenser, M B Mattammal and B B Davis ... Cooxidation of benzidine by renal medullary prostaglandin cyclooxygenase.. T V Zenser, M B Mattammal and B B Davis ... Cooxidation of benzidine by renal medullary prostaglandin cyclooxygenase. Message Subject (Your Name) has forwarded a page to ...
https://jpet.aspetjournals.org/content/211/3/460/tab-article-info
Toxicological profile for benzidineToxicological profile for benzidine
Title : Toxicological profile for benzidine Personal Author(s) : Choudhary, Gangadhar, 1935-;Citra, Mario J.;Llados, Fernando ...
https://stacks.cdc.gov/view/cdc/6478
Benzidine Yellow - B8 PowdersBenzidine Yellow - B8 Powders
Only logged in customers who have purchased this product may leave a review.. ...
https://b8powders.com/product/benzidine-yellow/
3,3´-benzidine-4,4´-dicarboxylic acid - SpectraBase3,3´-benzidine-4,4´-dicarboxylic acid - SpectraBase
3,3´-benzidine-4,4´-dicarboxylic acid Compound with open access spectra: 1 FTIR ...
https://spectrabase.com/compound/Le3qsRDDCij
Pigment Additive Manufacturers, Suppliers, Dealers & PricesPigment Additive Manufacturers, Suppliers, Dealers & Prices
Orange Benzidine Pigment Application: Industrial. Get latest price. Pragn Enterprise. Surat, India Plot No. 139, Pipodara GIDC ...
https://www.tradeindia.com/manufacturers/pigment-additive.html
Morphogenesis - 2nd EditionMorphogenesis - 2nd Edition
j . Benzidine Peroxidase. k. Indophenol Oxidase. l. Iron. m. Pigment. 6. Conclusion. Chapter II. Maturation and Fertilization. ...
https://www.elsevier.com/books/morphogenesis/raven/978-1-4832-1338-5
Study on Properties of Excited-state Intermolecular Proton Transfer (ESPT) Reaction Dendrite Containing Benzidine Fragments of...
Study on Properties of Excited-state Intermolecular Proton Transfer (ESPT) Reaction Dendrite Containing Benzidine Fragments of ... Study on Properties of Excited-state Intermolecular Proton Transfer (ESPT) Reaction Dendrite Containing Benzidine Fragments of ... 1. Study on Properties of Excited-state Intermolecular Proton Transfer (ESPT) Reaction Dendrite Containing Benzidine Fragments ... organic dyes benzidine fragments ((E)-2-(2-nitrobenzylideneamino)-biphenyl-3-ol (C1) and (E)-2-(2,4-dinitrobenzylideneamino)- ...
http://sioc-journal.cn/Jwk_hxxb/EN/10.6023/A19040109
NIOSHTIC-2 Search Results - Full View
study[7] enrolled workers exposed to benzidine and benzidine-based dyes at the time of the study and measured benzidine, and ... They state that mono N-acetylation of benzidine effectively precludes the activation of benzidine by PHS. However, Zenser and ... who had worked previously in factories where benzidine was present but who were not exposed to benzidine at the time of our ... analysis of benzidine, ABZ and DABZ before and after acid treatment provided an indirect measurement of the N-glucuronides of ...
http://www2a.cdc.gov/nioshtic-2/BuildQyr.asp?s1=Bell&f1=AU&Startyear=&terms=3&Adv=1&ct=&B1=Search&Limit=500&Sort=DP+DESC&whichdate=DP&D1=10&EndYear=&PageNo=29&RecNo=286&View=f&
中文中文
Benzidines [‎1]‎. Benzimidazoles [‎12]‎. Benzo(‎a)‎pyrene [‎5]‎. Benzofurans [‎3]‎. Benzoic Acid [‎1]‎. ...
https://extranet.who.int/iris/restricted/browse?locale-attribute=zh&etal=-1&type=mesh&starts_with_previous=D&offset=460&rpp=20&order=ASC&sort_by=-1
Reports and DecisionsReports and Decisions
Benzidine. Download the complete document in word or PDF format by clicking on the icons:. ...
http://www.pic.int/TheConvention/ChemicalReviewCommittee/ReportsandDecisions/tabid/1058/language/en-US/StyleSheetWidget
CFR - Code of Federal Regulations Title 21
Benzidine, not more than 1 part per billion. 1,3-Diphenyltriazene, not more than 40 parts per billion. ...
https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfCFR/CFRSearch.cfm?CFRPart=74&showFR=1&subpartNode=21:1.0.1.1.29.3
Substance Information - ECHASubstance Information - ECHA
Benzidine, its salts and benzidine derivatives - - Expert judgement (ECHA) [No public or meaningful name is available] - - ...
https://echa.europa.eu/de/substance-information/-/substanceinfo/100.009.386
Fatal Avian Influenza A H5N1 in a Dog - Volume 12, Number 11-November 2006 - Emerging Infectious Diseases journal - CDC
Diamino-benzidine was used as a substrate. Positive lung tissue from the dog that was incubated with phosphate-buffered saline ...
https://wwwnc.cdc.gov/eid/article/12/11/06-0542_article
HIV vaccine candidate activation of hypoxia and the inflammasome in CD14+ monocytes is associated with a decreased risk of...HIV vaccine candidate activation of hypoxia and the inflammasome in CD14+ monocytes is associated with a decreased risk of...
The tetramethyl benzidine solution was then added and incubated for 30 min. The reaction was stopped by adding the stop ... 40 μl ELISA Ultra tetramethyl benzidine substrate (Thermo Fisher) were added to each well and incubated at room temperature for ...
https://www.nature.com/articles/s41591-018-0025-7?error=cookies_not_supported&code=eb31fa73-9f5b-44a9-9543-88e029f9e7d8
Rule 3745-114-01 - Ohio Administrative Code | Ohio LawsRule 3745-114-01 - Ohio Administrative Code | Ohio Laws
benzidine (& dyes metabolized to benzidine). 00092-87-5. benzotrichloride. 00098-07-7. ...
https://codes.ohio.gov/ohio-administrative-code/rule-3745-114-01
Heat Stroke Workup: Laboratory Studies, ProceduresHeat Stroke Workup: Laboratory Studies, Procedures
Remember that urinary benzidine dipsticks do not differentiate between blood, hemoglobin, and myoglobin. Urine dipstick ...
https://www.medscape.com/answers/166320-61840/which-arterial-blood-gas-findings-suggest-heat-stroke
Nomination Summary for C.I. Direct black 38 (N76017)Nomination Summary for C.I. Direct black 38 (N76017)
Rationale: Benzidine-based dyes with high production NTP Principles: not specified Agents and Status ...
https://ntp.niehs.nih.gov/getinvolved/nominate/summary/nm-n76017.html
US Patent Application for CONDUCTING FORMULATION Patent Application (Application #20100213455 issued August 26, 2010) - Justia...US Patent Application for CONDUCTING FORMULATION Patent Application (Application #20100213455 issued August 26, 2010) - Justia...
... benzidine compounds; stilbene compounds; triazines; substituted metallo- or metal-free porphines, phthalocyanines, ...
https://patents.justia.com/patent/20100213455
Black Heel (Calcaneal Petechiae): Background, Pathophysiology, EpidemiologyBlack Heel (Calcaneal Petechiae): Background, Pathophysiology, Epidemiology
Benzidine stain for the histochemical detection of hemoglobin in splinter hemorrhage (subungual hematoma) and black heel. Am J ...
https://emedicine.medscape.com/article/1087469-overview
Can You Eat Pop Tarts Raw? - OR LiveCan You Eat Pop Tarts Raw? - OR Live
Benzidine, 4-aminobiphenyl and 4-aminoazobenzene are potential carcinogens. These chemicals may be found in foods and beverages ...
https://or-live.com/can-you-eat-pop-tarts-raw/
Proposition 65 List of Elabscience ChemicalsProposition 65 List of Elabscience Chemicals
Benzidine [and its salts] - 92-87-5 - Toxicity: cancer. *Benzidine-based dyes - Toxicity: cancer ...
https://caslab.com/Proposition-65-List/?setCurrencyId=3
Comparative analysis of host resistance to Sarcoptes scabiei var. cuniculi in two different rabbit breeds | Parasites & Vectors...Comparative analysis of host resistance to Sarcoptes scabiei var. cuniculi in two different rabbit breeds | Parasites & Vectors...
... the color was developed with tetramethyl benzidine (TMB) after incubation and thorough washing. Color intensity was measured at ...
https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-019-3764-5
Sounding out Congo RedSounding out Congo Red
It is a benzidine-based anionic disazo dye. Benzidine and Congo Red are, however, banned in many countries because of health ...
https://phys.org/news/2008-05-congo-red.html?deviceType=mobile
WHO EMRO | Status of mismatch repair genes hMSH2 and hMSH6 in colorectal cancer in Saudi patients: an immunohistochemical...
Diamino-benzidine was used as a chromogen. The sections were counterstained with haematoxylin, dehydrated in ascending ...
http://www.emro.who.int/emhj-volume-18-2012/issue-11/article-07.html
etx-tropical-ch3-fig10 - Endotext
DyesBladder cancerDiaminoSulfateZenserUrinaryProstaglandinRenalAromaticCompoundsChemicalsSubstanceHemoglobinReactionEditorStateWorkersReferenceBloodWorkers exposed to benzidineAmounts of benzidineCarcinogensCarcinogenDihydrochlorideAnilineExposureRearrangementHazardous waste sitesMetabolismSubstancesHorseradishStainsSubstrateEnters the environmentHumansSaltsCarcinogenicYellowCohortVaporPresumptiveMyeloperoxidaseSubstituteDeterminationOrganicParticlesSoilChemicalRubberCancerCellsHighFreeEffectsWater
Dyes9
  • However, the total number of NPL sites benzidine to produce dyes for cloth, paper, and evaluated for benzidine is not known. (cdc.gov)
  • This information is important because dye companies no longer make benzidine-based exposure to benzidine may harm you and because dyes. (cdc.gov)
  • This benzidine-based dyes (or products dyed with them) release does not always lead to exposure. (cdc.gov)
  • Some may also come from the chemical or biological breakdown of If you live near a hazardous waste site, you could be benzidine-based dyes, or from other dyes where it exposed to benzidine by drinking contaminated may exist as an impurity. (cdc.gov)
  • Meanwhile, organic dyes benzidine fragments (( E )-2'-(2-nitrobenzylideneamino)-biphenyl-3-ol ( C1 ) and ( E )-2'-(2,4-dinitrobenzylideneamino)-biphenyl-3-ol ( C3 )) which could undergo intermolecular proton transfer in excited states were synthetized via aminoaldehyde condensation of the intermediates biphenyl-2-amine and corresponding aldehyde. (sioc-journal.cn)
  • 7] demonstrated that acidic urine pH increased the level of both free ABZ and the dGp-ABZ adduct in exfoliated urothelial cells of workers exposed to benzidine and benzidine-based dyes, and that ABZ strongly correlated with adduct levels. (cdc.gov)
  • Carcinogens commonly associated with this condition: Aromatic amines, Benzidine and benzidine-based dyes, Ortho-Toluidine, Diesel engine exhaust, Arsenic and inorganic arsenic compounds etc. (360training.com)
  • 1,2-Diphenylhydrazine (CAS No. 122-66-7) has been used as an industrial intermediate, primarily in the manufacture of benzidine dyes. (who.int)
  • Benzidine dyes have not been produced for several decades in the USA and the European Union (EU), although they may still be used in other countries. (who.int)
Bladder cancer3
  • We thank Drs. Wang and King for their interest in our article on NAT2 acetylation and bladder cancer risk in workers exposed to benzidine. (cdc.gov)
  • Benzidine causes bladder cancer in human beings, but in mice it causes a neuroma of the acoustic nerve and intestinal and liver cancer. (healingcancernaturally.com)
  • In this situation, workers with certain types of NAT2 polymorphisms (form of gene with different observable properties) have an increased risk of bladder cancer when exposed to certain aromatic amines, while workers with other NAT2 polymorphisms may be protected from developing bladder cancer when exposed to benzidine in the absence of other aromatic amine exposures. (cdc.gov)
Diamino3
  • Diamino-benzidine was used as a substrate. (cdc.gov)
  • Diamino benzidine chromogen, 100x. (endotext.org)
  • Diamino benzidine was the substrate developed as a chromogen. (cdc.gov)
Sulfate1
  • benzidine dihydrochloride or benzidine sulfate). (cdc.gov)
Zenser1
  • These observations are consistent with the hypothesis that N-acetylbenzidine-glucuronide may have an important role in benzidine carcinogenesis, as Zenser et al. (cdc.gov)
Urinary1
  • Remember that urinary benzidine dipsticks do not differentiate between blood, hemoglobin, and myoglobin. (medscape.com)
Prostaglandin2
  • Cooxidation of benzidine by renal medullary prostaglandin cyclooxygenase. (aspetjournals.org)
  • 3] Drs. Wang and King question our comments on the role of peroxidatic activity of prostaglandin H synthase (PHS) in benzidine carcinogenesis. (cdc.gov)
Renal1
  • Se absorben a través de la piel y causan daño sanguíneo, vesical, hepático y renal letal y son carcinógenos potentes de amplio espectro en la mayoría de las especies. (bvsalud.org)
Aromatic1
  • We estimated pollution in Lake Edku and the Mediterranean Sea, El-Maadiya Region, with 3 aromatic amines [‎1-naphthylamine, 2-naphthylamine and benzidine]‎ in the muscle tissue of fish. (who.int)
Compounds1
  • 3] In contrast, workers in the factories we studied were exposed primarily to benzidine and related compounds. (cdc.gov)
Chemicals1
  • Prolonged and direct contact with the shoes' upper material can expose the wearer to the chemicals benzidine and/or dimethoxybenzidine, which are toxic and can cause adverse health effects. (cpsc.gov)
Substance2
  • The effects of exposure to any hazardous substance depend on Benzidine is a manufactured chemical that does not the dose, the duration, how you are exposed, occur naturally. (cdc.gov)
  • You may be exposed by breathing, 1.2 WHAT HAPPENS TO BENZIDINE WHEN eating, or drinking the substance, or by skin contact. (cdc.gov)
Hemoglobin1
  • Benzidine stain for the histochemical detection of hemoglobin in splinter hemorrhage (subungual hematoma) and black heel. (medscape.com)
Reaction2
  • One mononuclear cobalt(II) compound of the type [Co(bnzd) 2 (NCS) 2 (OH 2 ) 2 ] ( 1 ) (bnzd = benzidine) has been isolated through a single-pot reaction of the molecular building components in MeOH-H 2 O solvent mixture at room temperature and characterized by physico-chemical and spectroscopic methods. (ias.ac.in)
  • The reaction of s -triazine dicarboxylic acid derivatives with ethylenediamine, benzidine, piperazine, or p -phenylenediamine, afforded the target designed s -triazine polyamides. (rsc.org)
Editor1
  • Reply to the letter to the editor: N-Acetyltransferases and the susceptibility to benzidine-induced bladder carcinogenesis. (cdc.gov)
State1
  • They state that mono N-acetylation of benzidine effectively precludes the activation of benzidine by PHS. (cdc.gov)
Workers1
  • 3] As we noted in our article,[1] the apparent contradiction is explainable, at least in part, by the fact that workers in that report are likely to have been exposed to 2-naphthylamine, a monoarylamine, as well as to benzidine, a diarylamine (unpublished findings). (cdc.gov)
Reference1
  • The determination of sulphate: A study of the conditions necessary for the precipitation of benzidine sulphate, with special reference to the estimation of sulphates in urine. (semanticscholar.org)
Blood1
Workers exposed to benzidine1
  • NAT2 slow acetylation and bladder cancer in workers exposed to benzidine. (cdc.gov)
Amounts of benzidine1
  • Liver, kidney, immune, and neurological effects have been observed in laboratory animals given relatively high amounts of benzidine. (cdc.gov)
Carcinogens2
  • These relationships appear to be exposure-disease dependent, with examples for bladder cancer indicating a very long latency for potent International Agency for Research on Cancer (IARC) group I carcinogens like benzidine (30-35 years 3 ) and arsenic (up to 40 years). (bmj.com)
  • May also be contaminated with carcinogens such as benzidine. (foodbabe.com)
Carcinogen4
  • The Department of Health and Human Services (DHHS), the World Health Organization (WHO), and the EPA have determined that benzidine is a human carcinogen. (cdc.gov)
  • Metabolism of the human carcinogen, benzidine, in the isolated perfused rat liver. (nih.gov)
  • The diarylamine, benzidine, is also a strong bladder carcinogen, however, NAT2 N-acetylation is not key to its detoxification. (cdc.gov)
  • All three of these colors contain benzidine, a known human and animal carcinogen, though it's supposedly safe in small doses. (prevention.com)
Dihydrochloride2
  • benzidine dihydrochloride or benzidine sulfate). (cdc.gov)
  • Quantitative Determination of Hemoglobin and Cytochemical Staining for Peroxidase Using 3, 3 E 5, 5 ETetramethylbenzidine dihydrochloride, a Safe Substitute for Benzidine. (eu.com)
Aniline2
  • Benzidine Yellow G is a diarylide aniline yellow pigment that is commonly used in offset inks, water-based inks, solvent-based inks, and coatings. (cetrimidemanufacturer.com)
  • Because it's less susceptible to the oxidative metabolism but the physicochemical parameter of the Azo compounds such as aniline, benzidine, and naphthalene varies. (grabmyessay.com)
Exposure14
  • It is known that long term occupational exposure to benzidine can increase the risk of developing cancer in people. (cdc.gov)
  • We do not know if exposure to benzidine will result in birth defects or other developmental effects in people. (cdc.gov)
  • How can families reduce the risk of exposure to benzidine? (cdc.gov)
  • Benzidine and its breakdown products can be detected in your urine, but only within about 2 weeks after your last exposure. (cdc.gov)
  • The effects of exposure to any hazardous substance depend on Benzidine is a manufactured chemical that does not the dose, the duration, how you are exposed, occur naturally. (cdc.gov)
  • In the benzidine and the effects of exposure. (cdc.gov)
  • Benzidine is no longer used in medical these sites may be sources of exposure. (cdc.gov)
  • The number of workers with potential exposure to benzidine is greater than previously thought. (cdc.gov)
  • Which cancers are associated with exposure to benzidine? (thailandcancerhelp.com)
  • Occupational exposure to benzidine results in an increased risk of bladder cancer , according to studies of workers in different geographic locations. (thailandcancerhelp.com)
  • A protective association was observed for the slow NAT2 genotype (bladder cancer odds ratio (OR)=0.3, 95% confidence interval (CI) 0.11-0.99) after adjustment for cumulative benzidine exposure and lifetime smoking. (cdc.gov)
  • The interaction between NAT2 polymorphism and benzidine exposure was evaluated: compared to rapid acetylators with high exposure, the respective risks were OR=0.5 (95% CI 0.26-1.05) for rapid acetylators with low exposure, OR=0.4 (95% CI 0.12-1.57) for slow acetylators with high exposure, and OR=0.1 (95% CI 0.03-0.61) for slow acetylators with low exposure (test for multiplicative interaction, p=0.58). (cdc.gov)
  • In the current issue, Millerick-May et al add to the body of literature identifying a strong and consistent association between benzidine exposure and risk of bladder cancer in a cohort of workers employed at a benzidine-producing facility. (bmj.com)
  • These analyses can include evaluations of time since first exposure and time since last exposure, which help to inform the latency of benzidine-related bladder cancer as well as how long after elimination of exposure risks decline. (bmj.com)
Rearrangement2
  • His investigations of the benzidine rearrangement likewise solved the longstanding question of mechanism. (ttu.edu)
  • The mechanism of the benzidine rearrangement. (caltech.edu)
Hazardous waste sites2
  • People living near uncontrolled hazardous waste sites may be exposed to benzidine. (cdc.gov)
  • Children should avoid playing in soils near uncontrolled hazardous waste sites where benzidine may have been discarded. (cdc.gov)
Metabolism1
  • Citation: Luster MI, Tucker AN, Hayes HT, Pung OJ, Burka T, McMillan R, Eling T. Immunosuppressive effects of benzidine in mice: evidence of alterations in arachidonic acid metabolism. (nih.gov)
Substances2
  • Toxic Substances Portal - Benzidine. (thailandcancerhelp.com)
  • According to the ANSES (National Agency for Food Safety, Environment and Occupational Health) report, you can find substances such as benzidine, chromium-6 or even nickel on your new clothes. (rawthoughtsandfeelings.com)
Horseradish1
  • Colorimetric assays predicated on horseradish peroxidase/3,3,5,5-tetramethyl-benzidine (HRP/TMB) program have recently obtained much attention because of their various advantages such as for Enzastaurin cell signaling example high awareness, low toxicity and basic administration16,17,18. (stopvivisection.info)
Stains1
  • Histochemically, benzidine stains are positive, proving the pigment is derived from hemoglobin.Extravasated red blood cells in the stratum corneum are protected from phagocytes. (psychiatryadvisor.com)
Substrate2
  • Diamino-benzidine was used as a substrate. (cdc.gov)
  • Tetramethyl-benzidine (TMB) is the substrate. (pblassaysci.com)
Enters the environment1
  • What happens to benzidine when it enters the environment? (cdc.gov)
Humans1
  • Except for the cancer discussed next, benzidine has not been definitely shown to cause major adverse health effects in humans. (cdc.gov)
Salts1
  • benzidine salts can dissolve more readily in water. (cdc.gov)
Carcinogenic1
  • It has been developed as an alternative to benzidine, which is a carcinogenic chemical. (eu.com)
Yellow2
  • Supported by experienced professionals, we are manufacturing and supplying an excellent stock of Benzidine Yellow G . Formulated using innovative machines in compliance with set industry standards, the offered pigment is highly appreciated in the market. (cetrimidemanufacturer.com)
  • Benzidine Yellow has good lightfastness. (dickblick.com)
Cohort1
  • The combined analysis included 68 cases and 107 controls from a cohort of benzidine dye producers in China exposed occupationally to benzidine, of which 30 cases and 67 controls had not been previously studied. (cdc.gov)
Vapor1
  • Benzidine in the air exists as a vapor or attached to very small particles. (cdc.gov)
Presumptive1
  • The preliminary presumptive test for blood using the chemical benzidine gave a positive result for two locations on the chair-one on the back, and the other on the front of the seat. (thehenryford.org)
Myeloperoxidase1
  • Films prepared in the same manner but treated with benzidine/H2O2 medium for myeloperoxidase did not reveal these particles. (duke.edu)
Substitute1
  • A Safer Substitute for Benzidine in the Detection of Blood. (eu.com)
Determination2
  • The method was applied for the determination of benzidine in the river, sea, and tap waters. (hindawi.com)
  • In addition to applying the method for determination of benzidine in various water samples. (hindawi.com)
Organic2
  • In the environment, benzidine is found in either its "free" state (as an organic base), or as a salt. (cdc.gov)
  • Diarylides are synthetic organic pigments formed by the coupling of tetraazotized benzidines with acetoacetarylides. (artistsupplysource.com)
Particles1
  • Benzidine in soil is likely to be strongly attached to soil particles and will not easily pass into underground water. (cdc.gov)
Soil1
  • The general population is not likely to be exposed to benzidine through contaminated air, water, soil, or food. (cdc.gov)
Chemical5
  • Benzidine is a manufactured chemical that does not occur naturally. (cdc.gov)
  • Benzidine is a manufactured chemical that does not occur in nature. (thailandcancerhelp.com)
  • Benzidine, NIOSH Pocket Guide to Chemical Hazards. (thailandcancerhelp.com)
  • The U.S. Consumer Product Safety Commission (CPSC) has issued a recall for Dr. Martens unisex Vegan 1460 boots because the lining contains benzidine, a chemical that can cause irritation after prolonged contact. (bradleygrombacher.com)
  • Benzidine is a chemical listed under California's Prop 65 which requires companies to include a warning if their product contains a listed chemical. (bradleygrombacher.com)
Rubber1
  • However, benzidine has not been sold in the United States since the mid-1970s, and it is no longer used in medical laboratories or in the rubber and plastics industries. (thailandcancerhelp.com)
Cancer5
  • How likely is benzidine to cause cancer? (cdc.gov)
  • The purpose of this study was to expand on a previous study that evaluated the impact of NAT2 polymorphisms on bladder cancer in male subjects exposed only to benzidine. (cdc.gov)
  • RÉSUMÉ Afin d'atteindre les objectifs de santé fixés par le pays pour 2011-2016, une analyse qualitative de l'exposition aux facteurs de risque de cancer au Qatar a été conduite en 2013. (who.int)
  • Les risques de cancer les plus élevés pour les Qatariens proviendraient de facteurs associés aux modes de vie, en particulier l'obésité, la sédentarité et le tabagisme. (who.int)
  • Under Prop 65, benzidine is also listed as causing cancer. (bradleygrombacher.com)
Cells3
  • Benzidine and its breakdown products can also bind to proteins within your red blood cells, and this can be detected for up to 4 months. (cdc.gov)
  • 14. Induction of DNA damage signaling genes in benzidine-treated HepG2 cells. (nih.gov)
  • These cells exhibited a delay in the appearance of heme‐producing, benzidine‐reactive (B+) cells and a decreased rate of cell proliferation in comparison to the control not containing BU‐DNA. (elsevier.com)
High1
  • It is likely that health effects seen in children exposed to high levels of benzidine will be similar to the effects seen in adults. (cdc.gov)
Free1
Effects1
  • There are no studies on health effects on children exposed to benzidine. (cdc.gov)
Water2
  • The benzidine in air will eventually settle over land and water. (cdc.gov)
  • The EPA recommends that the amount of benzidine in drinking water be less than 1 part benzidine in a trillion parts of water (1 ppt). (cdc.gov)
RTECS:DD0875000 - Benzidine, 3,3'-dimethoxy- - The Registry of Toxic Effects of Chemical Substances | CDC/NIOSH
RTECS:DD0875000 - Benzidine, 3,3'-dimethoxy- - The Registry of Toxic Effects of Chemical Substances | CDC/NIOSH (cdc.gov)
Preventing Health Hazards From Exposure to Benzidine Congener Dyes (83-105) | NIOSH | CDC
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Alphabetical Method Listing - B - NMAM 4th Edition | NIOSH | CDC
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Benzidine hydrochloride | Semantic Scholar
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Fatal Avian Influenza A H5N1 in a Dog - Volume 12, Number 11-November 2006 - Emerging Infectious Diseases journal - CDC
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NIOSH Alert Reprints: October 1980 - December 1986 | NIOSH | CDC
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NIOSH eNews - January 2017 | NIOSH | CDC
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Avian Influenza H5N1 in Naturally Infected Domestic Cat - Volume 12, Number 4-April 2006 - Emerging Infectious Diseases journal...
Avian Influenza H5N1 in Naturally Infected Domestic Cat - Volume 12, Number 4-April 2006 - Emerging Infectious Diseases journal... (wwwnc.cdc.gov)
CFR - Code of Federal Regulations Title 21
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Heat Stroke Workup: Laboratory Studies, Procedures
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HIV vaccine candidate activation of hypoxia and the inflammasome in CD14+ monocytes is associated with a decreased risk of...
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Serologic Evidence of Frequent Human Infection with WU and KI Polyomaviruses - Volume 15, Number 8-August 2009 - Emerging...
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Characterization of Flagella Produced by Clinical Strains of Stenotrophomonas maltophilia - Volume 8, Number 9-September 2002 -...
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NIOSH Current Intelligence Bulletin Reprints - Bulletins 19 thru 30 for 1978 (79-146) | NIOSH | CDC
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WHO EMRO | Status of mismatch repair genes hMSH2 and hMSH6 in colorectal cancer in Saudi patients: an immunohistochemical...
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