Benzhydryl Compounds
Molecular Structure
Sulfur Compounds
Volatile Organic Compounds
Structure-Activity Relationship
Plant Extracts
Drug Evaluation, Preclinical
Encyclopedias as Topic
Benzene
Toxic, volatile, flammable liquid hydrocarbon byproduct of coal distillation. It is used as an industrial solvent in paints, varnishes, lacquer thinners, gasoline, etc. Benzene causes central nervous system damage acutely and bone marrow damage chronically and is carcinogenic. It was formerly used as parasiticide.
Pets
Legislation, Veterinary
Food Contamination
Enzyme-Linked Immunosorbent Assay
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Oligochaeta
Tumor Necrosis Factor-alpha
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
Inflammation
Lipopolysaccharides
Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)
Cytokines
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
Protriptyline
Thromboxane A2
Foramen Ovale, Patent
Receptors, Thromboxane
Search Engine
Carboxylic Acids
Isatin
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Czechoslovakia
Heterocyclic Compounds
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Community Medicine
Bland White Garland Syndrome
Granuloma Inguinale
Exhibits as Topic
Alexander Disease
Rare leukoencephalopathy with infantile-onset accumulation of Rosenthal fibers in the subpial, periventricular, and subependymal zones of the brain. Rosenthal fibers are GLIAL FIBRILLARY ACIDIC PROTEIN aggregates found in ASTROCYTES. Juvenile- and adult-onset types show progressive atrophy of the lower brainstem instead. De novo mutations in the GFAP gene are associated with the disease with propensity for paternal inheritance.
Pastoral Care
The vigilance promoting drug modafinil increases extracellular glutamate levels in the medial preoptic area and the posterior hypothalamus of the conscious rat: prevention by local GABAA receptor blockade. (1/1043)
The effects of modafinil on glutamatergic and GABAergic transmission in the rat medial preoptic area (MPA) and posterior hypothalamus (PH), are analysed. Modafinil (30-300 mg/kg) increased glutamate and decreased GABA levels in the MPA and PH. Local perfusion with the GABAA agonist muscimol (10 microM), reduced, while the GABAA antagonist bicuculline (1 microM and 10 microM) increased glutamate levels. The modafinil (100 mg/kg)-induced increase of glutamate levels was antagonized by local perfusion with bicuculline (1 microM). When glutamate levels were increased by the local perfusion with the glutamate uptake inhibitor L-trans-PDC (0.5 mM), modafinil produced an additional enhancement of glutamate levels. Modafinil (1-33 microM) failed to affect [3H]glutamate uptake in hypothalamic synaptosomes and slices. These findings show that modafinil increases glutamate and decreases GABA levels in MPA and PH. The evidence that bicuculline counteracts the modafinil-induced increase of glutamate levels strengthens the evidence for an inhibitory GABA/glutamate interaction in the above regions controlling the sleep-wakefulness cycle. (+info)Inhibition by a coantioxidant of aortic lipoprotein lipid peroxidation and atherosclerosis in apolipoprotein E and low density lipoprotein receptor gene double knockout mice. (2/1043)
Antioxidants can inhibit atherosclerosis in animals, though it is not clear whether this is due to the inhibition of aortic lipoprotein lipid (per)oxidation. Coantioxidants inhibit radical-induced, tocopherol-mediated peroxidation of lipids in lipoproteins through elimination of tocopheroxyl radical. Here we tested the effect of the bisphenolic probucol metabolite and coantioxidant H 212/43 on atherogenesis in apolipoprotein E and low density lipoprotein (LDL) receptor gene double knockout (apoE-/-;LDLr-/-) mice, and how this related to aortic lipid (per)oxidation measured by specific HPLC analyses. Dietary supplementation with H 212/43 resulted in circulating drug levels of approximately 200 microM, increased plasma total cholesterol slightly and decreased plasma and aortic alpha-tocopherol significantly relative to age-matched control mice. Treatment with H 212/43 increased the antioxidant capacity of plasma, as indicated by prolonged inhibition of peroxyl radical-induced, ex vivo lipid peroxidation. Aortic tissue from control apoE-/-;LDLr-/- mice contained lipid hydro(pero)xides and substantial atherosclerotic lesions, both of which were decreased strongly by supplementation of the animals with H 212/43. The results show that a coantioxidant effectively inhibits in vivo lipid peroxidation and atherosclerosis in apoE-/-;LDLr-/- mice, consistent with though not proving a causal relationship between aortic lipoprotein lipid oxidation and atherosclerosis in this model of the disease. (+info)Comparative formation, distribution, and elimination kinetics of diphenylmethoxyacetic acid (a diphenhydramine metabolite) in maternal and fetal sheep. (3/1043)
Deamination to diphenylmethoxyacetic acid (DPMA) is the major route of diphenhydramine (DPHM) clearance in many species. In this study, we assessed the contribution of this pathway to nonplacental DPHM elimination and disposition of DPMA in maternal and fetal sheep. Paired maternal-fetal experiments were conducted in five chronically catheterized pregnant sheep (124-140 days gestation) with an appropriate washout period in between. Both maternal and fetal dosing experiments involved administration of an i.v bolus of deuterium-labeled DPMA ([2H10]-DPMA) combined with a 6-h infusion of DPHM (or a bolus of unlabeled DPMA with an infusion of deuterium-labeled DPHM). Maternal and fetal arterial plasma and urine samples were collected and analyzed for DPMA, [2H10]-DPMA, DPHM, and deuterium-labeled DPHM concentrations using gas chromatography-mass spectrometry. The preformed DPMA (or [2H10]-DPMA) had a substantially lower clearance (maternal: 0.55 +/- 0.18 versus 40.9 +/- 14.0 ml/min/kg; fetal: 0.37 +/- 0.11 versus 285. 6 +/- 122.2 ml/min/kg) and steady-state volume of distribution (Vdss, maternal: 0.10 +/- 0.02 versus 2.1 +/- 1.1 l/kg; fetal: 0.40 +/- 0. 06 versus 13.1 +/- 3.1 l/kg) as compared with the parent drug. The contribution of DPMA formation to maternal and fetal DPHM nonplacental clearance in vivo was 1.78 +/- 2.12% and 0.87 +/- 0.56%, respectively, indicating that DPMA formation is not a major route of DPHM clearance in fetal or maternal sheep. The recoveries of DPMA (or [2H10]-DPMA) in maternal urine were 88.0 +/- 6.5 and 92.1 +/- 7. 4% of the administered dose during maternal and fetal dosing experiments, respectively. Thus, this metabolite does not appear to be secondarily metabolized in fetal or maternal sheep. These findings are in contrast to other species (dog, rhesus monkey, human) where DPMA and its conjugates constitute approximately 40 to 60% of the total DPHM metabolites. (+info)Tolterodine does not affect the human in vivo metabolism of the probe drugs caffeine, debrisoquine and omeprazole. (4/1043)
AIM: To investigate the in vivo effect of treatment with tolterodine on debrisoquine 4-hydroxylation (an index of CYP2D6 activity), omeprazole 5-hydroxylation (CYP2C19), omeprazole sulphoxidation (CYP3A4) and caffeine N3-demethylation (CYP1A2). METHODS: Twelve healthy male volunteers (eight extensive metabolisers [EMs] and four poor metabolisers [PMs] with respect to CYP2D6) received 4 mg tolterodine L-tartrate orally twice daily for 6 days. All subjects were EMs with respect to CYP2C19. The subjects received single oral doses of debrisoquine (10 mg), omeprazole (20 mg) and caffeine (100 mg) for determination of the appropriate metabolic ratios (MR). The drugs were given on separate consecutive days, before, during and after the co-administration of tolterodine. RESULTS: Mean serum tolterodine concentrations were 5-10 times higher in PMs than in EMs. Serum concentrations of the active 5-hydroxymethyl metabolite of tolterodine, 5-HM, were not quantifiable in PMs. The mean MR of debrisoquine (95% confidence interval) during tolterodine treatment was 0.50 (0.25-0.99) and did not differ statistically from the values before [0.49 (0.20-1.2)] and after tolterodine administration [0.46 (0.14-1.6)] in EMs. The mean MR of omeprazole hydroxylation and sulphoxidation or caffeine metabolism were not changed in the presence of tolterodine in either EMs or PMs. Debrisoquine and caffeine had no significant effect on the AUC(1,3 h) of either tolterodine or 5-HM, but during omeprazole administration small decreases (13-19%) in these parameters were seen. CONCLUSIONS: Tolterodine, administered at twice the expected therapeutic dosage, did not change the disposition of the probe drugs debrisoquine, omeprazole and caffeine and thus had no detectable effect on the activities of CYPs 2D6, 2C19, 3A4 and 1A2. Alteration of the metabolism of substrates of these enzymes by tolterodine is unlikely to occur. (+info)Effect of neonatal exposure to estrogenic compounds on development of the excurrent ducts of the rat testis through puberty to adulthood. (5/1043)
Neonatal exposure to diethylstilbestrol (DES) can alter the structure of the testicular excurrent ducts in rats. We characterized these changes according to dose and time posttreatment and established whether potent estrogens (ethinyl estradiol), environmental estrogens (genistein, octylphenol, bisphenol A, parabens), and tamoxifen induce such changes. Rats were administered these compounds neonatally and assessed at several time points during (day 10, or day 18 for some treatments) and after (days 18, 25, 35, and 75) the treatment period to detect any changes in testis weight, distension of the rete testis and efferent ducts, epithelial cell height in the efferent ducts, and immunoexpression of the water channel aquaporin-1 (AQP-1). Treatment with DES (10, 1, or 0.1 microg/injection; equivalent to 0.37, 0.037, or 0.0037 mg/kg/day, respectively) induced dose-dependent changes in testis weight and all parameters. These effects were most pronounced at days 18 and 25 and appeared to lessen with time, although some persisted into adulthood. Neonatal treatment with ethinyl estradiol (10 microg/injection; equivalent to 0.37 mg/kg/day) caused changes broadly similar to those induced by 10 mg DES. Administration of tamoxifen (2 mg/kg/day) caused changes at 18 days that were similar to those induced by 1 microg DES. Treatment with genistein (4 mg/kg/day), octylphenol (2 mg/injection; equivalent to 150 mg/kg/day), or bisphenol A (0.5 mg/injection; equivalent to 37 mg/kg/day) caused minor but significant (p<0.05) decreases in epithelial cell height of the efferent ducts at days 18 and/or 25. In animals that were followed through to 35 days and/or adulthood, these changes were no longer obvious; other parameters were either unaffected or were affected only marginally and transiently. Administration of parabens (2 mg/kg/day) had no detectable effect on any parameter at day 18. To establish whether these effects of estrogens were direct or indirect (i.e., resulting from reduced follicle-stimulating hormone/luteinizing hormone secretion), the above end points were assessed in animals in which gonadotropin secretion was suppressed neonatally by administration of a gonadotropin-releasing hormone antagonist. This treatment permanently reduced testis weight, but did not affect any of the other end points, apart from a minor transient reduction in efferent duct epithelial cell height at 18 days. This study suggests that structural and functional (expression of AQP-1) development of the excurrent ducts is susceptible to impairment by neonatal estrogen exposure, probably as a consequence of direct effects. The magnitude and duration of adverse changes induced by treatment with a range of estrogenic compounds was broadly comparable to their estrogenic potencies reported from in vitro assays. (+info)Glucuronidation of the environmental oestrogen bisphenol A by an isoform of UDP-glucuronosyltransferase, UGT2B1, in the rat liver. (6/1043)
Bisphenol A, an environmental oestrogenic chemical, was found to conjugate highly with glucuronic acid in male rat liver microsomes studied in vitro. In the various isoforms tested (1A1, 1A3, 1A5, 1A6, 1A7 and 2B1), glucuronidation of bisphenol A and of diethylstilboestrol, a synthetic crystalline compound possessing oestrogenic activity and known to be glucuronidated by liver microsomes, was catalysed by an isoform of UDP-glucuronosyltransferase (UGT), namely UGT2B1, which glucuronidates some endogenous androgens. UGT activity towards bisphenol A in liver microsomes and in UGT2B1 expressed in yeast AH22 cells (22.9 and 0.58 nmol/min per mg of microsomal proteins respectively) was higher than that towards diethylstilboestrol (75.0 and 4.66 pmol/min per mg of microsomal proteins respectively). UGT activities towards both bisphenol A and diethylstilboestrol were distributed mainly in the liver but were also observed at substantial levels in the kidney and testis. Northern blot analysis disclosed the presence of UGT2B1 solely in the liver, and about 65% of the male rat liver microsomal UGT activities towards bisphenol A were absorbed by the anti-UGT2B1 antibody. These results indicate that bisphenol A, in male rat liver, is glucuronidated by UGT2B1, an isoform of UGT. (+info)UK-78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage-gated potassium channel and inhibits human T cell activation. (7/1043)
1. UK-78,282, a novel piperidine blocker of the T lymphocyte voltage-gated K+ channel, Kv1.3, was discovered by screening a large compound file using a high-throughput 86Rb efflux assay. This compound blocks Kv1.3 with a IC50 of approximately 200 nM and 1:1 stoichiometry. A closely related compound, CP-190,325, containing a benzyl moiety in place of the benzhydryl in UK-78,282, is significantly less potent. 2 Three lines of evidence indicate that UK-78,282 inhibits Kv1.3 in a use-dependent manner by preferentially blocking and binding to the C-type inactivated state of the channel. Increasing the fraction of inactivated channels by holding the membrane potential at - 50 mV enhances the channel's sensitivity to UK-78,282. Decreasing the number of inactivated channels by exposure to approximately 160 mM external K+ decreases the sensitivity to UK-78,282. Mutations that alter the rate of C-type inactivation also change the channel's sensitivity to UK-78,282 and there is a direct correlation between tau(h) and IC50 values. 3. Competition experiments suggest that UK-78,282 binds to residues at the inner surface of the channel overlapping the site of action of verapamil. Internal tetraethylammonium and external charybdotoxin do not compete UK-78,282's action on the channel. 4. UK-78,282 displays marked selectivity for Kv1.3 over several other closely related K+ channels, the only exception being the rapidly inactivating voltage-gated K+ channel, Kv1.4. 5. UK-78,282 effectively suppresses human T-lymphocyte activation. (+info)Functional magnetic resonance imaging neuroactivation studies in normal subjects and subjects with the narcoleptic syndrome. Actions of modafinil. (8/1043)
Functional magnetic resonance imaging (fMRI) can be used to detect regional brain responses to changes in sensory stimuli. We have used fMRI to determine the amount of visual and auditory cortical activation in 12 normal subjects and 12 subjects with the narcoleptic syndrome, using a multiplexed visual and auditory stimulation paradigm. In both normal and narcoleptic subjects, mean cortical activation levels during the presentation of periodic visual and auditory stimulation showed no appreciable differences with either age or sex. Normal subjects showed higher levels of visual activation at 10:00 hours than 15:00 hours, with a reverse pattern in narcoleptic subjects (P = 0.007). The group differences in spatial extent of cortical activation between control and narcoleptic subjects were small and statistically insignificant. The alerting action, and imaging response, to a single oral dose of the sleep-preventing drug modafinil 400 mg were then determined and compared with placebo in both the 12 normal (8 given modafinil, 4 placebo) and 12 narcoleptic subjects (8 modafinil, 4 placebo). Modafinil caused an increase in self-reported levels of alertness in 7 of 8 narcoleptic subjects, but there was no significant difference between mean pretreatment and post-treatment activation levels as determined by fMRI for either normal or narcoleptic syndrome subjects given modafinil. However, in the modafinil-treated group of 8 normal and 8 narcoleptic subjects, there was a clock time independent correlation between the initial level of activation as determined by the pretreatment scan and the post-treatment change in activation (visual, P = 0.002; and auditory, P = 0.001). No correlation was observed in placebo-treated subjects (P = 0.99 and 0.77, respectively). Although limited by the small number of subjects, and the lack of an objective measure of alertness, the findings of this study suggest that low cortical activation levels in both normal and narcoleptic subjects are increased following the administration of modafinil. Functional magnetic resonance imaging may be a valuable addition to established studies of attention. (+info)
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Diphenylmethane
Benzhydryl compounds Triphenylmethane Tetraphenylmethane W. W. Hartman and Ross Phillips (1934). "Diphenylmethane". Organic ... Diphenylmethane is an organic compound with the formula (C6H5)2CH2 (often abbreviated CH 2Ph 2). The compound consists of ... The diphenylmethyl group is also known as benzhydryl. It is prepared by the Friedel-Crafts alkylation of benzyl chloride with ...
Modafinil
... originated with the late 1970s invention of a series of benzhydryl sulfinyl compounds, including adrafinil, which was ... It is also a schedule IV compound. Krishnan R, Chary KV (2015). "A rare case modafinil dependence". Journal of Pharmacology & ... U.S. Patent 4,927,855 was issued to Laboratoire L. Lafon on May 22, 1990, covering the chemical compound modafinil. After ... Modafinil is a highly researched compound, with many derivatives created and studied, some examples and their differences ...
Benzhydryl compounds
The benzhydryl compounds are a group of organic compounds whose parent structures include diphenylmethane (which is two benzene ... U.S. Patent 4,022,786 Benzhydryl+Compounds at the US National Library of Medicine Medical Subject Headings (MeSH) ... tyrima Olanzapine Benzhydryl Compounds at the US National Library of Medicine Medical Subject Headings (MeSH) "Abbreviations ... Bromodiphenylmethane from PubChem, a.k.a. called benzhydryl bromide 1-Benzyl-2-bromobenzene from PubChem, not called benzhydryl ...
Diphenylmethylpiperazine
It features a piperazine ring with a benzhydryl (diphenylmethyl) group bound to one of the nitrogens. Calderon SN. Nonpeptidic ... 1-(Diphenylmethyl)piperazine, also known as benzhydrylpiperazine, is a chemical compound and piperazine derivative. ...
NK1 receptor antagonist
The compound CP-99994 was synthesized by replacing the quinuclidine ring with a piperidine ring and benzhydryl moiety by a ... Many compounds have been described by various pharmaceutical companies besides the compounds that led to the discovery of ... However, these compounds, like most peptide compounds, had problems with selectivity, potency, solubility and bioavailability. ... This compound showed good activity in vivo and in models of pain and was developed up to phase II for the treatment of ...
Katarína Horáková
Benzhydryl- and cinamoylisothiocyanates". Neoplasma. 16 (6): 591-6. PMID 5369024. Horáková, K; Drobnica, L; Nemec, P; Uher, M ( ... Horáková, K. (1981). "The Use of Cell Cultures to Monitor the Toxic and Mutagenic Activity of Chemical Compounds Present in ... Horáková, K. (1967). "A Study of synergism of known metabolic inhibitors and antifungal compounds on Candida albicans Pn 10". ... Horáková, K; Drobnica, L; Nemec, P (1969). "Cytotoxic and cancerostatic effects of isothiocyanates and related compounds. IV. ...
Budipine
Tert-butyl compounds. *Benzhydryl compounds. *Nervous system drug stubs. Hidden categories: *CS1 maint: multiple names: authors ...
Diphenylprolinol
Benzhydryl compounds. Hidden categories: *All articles with dead external links. *Articles with dead external links from June ...
Diphenylmethanol
... is the organic compound with the formula (C6H5)2CHOH. Also known as benzhydrol, it is a white solid and the ... It is used in the synthesis of Modafinil and the benzhydryl group is present in the structure of many histamine H1 antagonists ... Benzhydrol is also used in the production of agrochemicals as well as other organic compounds and as a terminating group in ...
Di-pi-methane rearrangement
One was the photolysis of the Mariano Compound, 3,3-methyl-1,1,5,5-tetraphenyl-1,4-pentadiene. Another was the reaction of the ... Process a is preferred since it leaves benzhydryl odd-electron stabilization intact. Equation 2. The mechanism of the Pratt ...
JNJ-7925476
The compounds as depicted have the carbon of the pyrrolidine carbon and the phenyl cis, but Maryanoff and coworkers are of the ... The structure is a pyrroloisoquinoline core, with an overlaid benzhydryl motif. Incorporating the pyrrolidino ring onto the ... opinion that the compound is trans. (see abstract) The reason for this is not known because it was referred to as "cis" in ...
Leonidas Zervas
In his attempts he introduced new mercaptan protecting groups (e.g. trityl, benzhydryl or benzoyl), which finally made it ... On the Aldehyde Compounds of Amino Acids Katsoyannis, P. G., ed. (1973). The Chemistry of Polypeptides. New York: Plenum Press ...
Iphigenia Photaki
... benzhydryl or benzoyl groups (as part of the greater effort for the synthesis of asymmetric cysteine-containing peptides), N- ... Symposium on Natural Sulfur Compounds (Copenhagen, 1966), NATO Seminar of Molecular Biology (Spetses, 1966), 8th EPS (Noordwijk ...
Hydrogen-bond catalysis
For example, in a typical acyl substitution reaction, the starting carbonyl compound is coordinated to the catalyst through one ... the formation of the Strecker product from benzhydryl amines and aqueous HCN. Hydrolysis of the nitrile and deprotections ... Furthermore, analogous reactions involving oxyanion intermediates such as enolate addition to nitroso compounds or opening of ... In addition, aza-Friedel-Crafts reactions of furans, amidoalkylations of diazocarbonyl compounds, asymmetric ...
Captodiame
Reduction of the ketone with zinc/NaOH followed by treatment with HCl in ether affords the benzhydryl chloride. Displacement of ...
Ezlopitant
2S,3S)-2-Benzhydryl-N-[(5-isopropyl-2-methoxy-phenyl)methyl]quinuclidin-3-amine ... Isopropyl compounds. *Gastrointestinal system drug stubs. Hidden categories: *Drugs with non-standard legal status ...
Benzhydryl compounds - Wikipedia
Benzhydryl compounds are compounds that are "diphenylmethane"-containing, i.e. containing two benzene rings adjoining a single ... This does not include compounds where these benzenes are fused to other rings.[1] Benzhydryl can be abbreviated to CHPh2 or Bzh ... Benzhydryl+Compounds at the US National Library of Medicine Medical Subject Headings (MeSH) ... Benzhydryl+Compounds at the US National Library of Medicine Medical Subject Headings (MeSH) ...
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Determination of bisphenol A in canned pet foods
MEDLINE - Resultado p gina 1
0 (Benzhydryl Compounds); 0 (Phenols); 0 (Soil); 0 (Soil Pollutants); MLT3645I99 (bisphenol A). ... They contain not only nutrients but also xenobiotics, such as Bisphenol A (BPA). These compounds are not regulated in the use ... 0 (Biomarkers); 0 (Organometallic Compounds); 0 (Soil); 0 (Soil Pollutants); HS813P8QPX (bismuth tripotassium dicitrate). ... bismuth sequestered by metal-binding compounds. After 28 days of exposure bismuth concentrations in earthworms tissue increased ...
MEDLINE - Resultado p gina 1
0 (Aromatase Inhibitors); 0 (Benzhydryl Compounds); 0 (Endocrine Disruptors); 0 (Ligands); 0 (Nitriles); 0 (Phenols); 0 ( ... Due to this role, it is likely to be a target of the so-called endocrine disrupting chemicals, a series of compounds able to ... If on one side the toxicity of some compounds such as bisphenol A is well known, on the other side the toxic concentrations of ... Here the so-called alkali assay previously developed in our laboratory is applied to test the effect of different compounds on ...
Amphetamine : Wikis (The Full Wiki)
Eugeroics / Benzhydryl compounds. Adrafinil • Armodafinil • Modafinil. Histamine H3 receptor antagonists. A-349,821 • ABT-239 ... List of 504 Compounds Similar to Amphetamine (PubChem) - Similar Compounds for PubChem Compound (Select 3007) - PubChem ... Amphetamine was first synthesized in 1887 by the Romanian chemist Lazăr Edeleanu in Berlin, Germany.[5] He named the compound ... The related compound methamphetamine was first synthesized from ephedrine in Japan in 1918 by chemist Akira Ogata, via ...
Guanfacine : Wikis (The Full Wiki)
Genistein suppressed epithelial-mesenchymal transition and migration efficacies of BG-1 ovarian cancer cells activated by...
Diphenylmethane - Wikipedia
Benzhydryl compounds Triphenylmethane Tetraphenylmethane W. W. Hartman and Ross Phillips (1934). "Diphenylmethane". Organic ... Diphenylmethane is an organic compound with the formula (C6H5)2CH2 (often abbreviated CH 2Ph 2). The compound consists of ... The diphenylmethyl group is also known as benzhydryl. It is prepared by the Friedel-Crafts alkylation of benzyl chloride with ...
Publication Detail
Cyclizine
Other names: Piperazine, 1-(diphenylmethyl)-4-methyl-; (N-Benzhydryl)(N-methyl)diethylenediamine; Compound 47-83; Marezine; N- ... 47-83; 1-Diphenylmethyl-4-methylpiperazine; Bw 47-83; Ciclizina; N-Methyl-N-benzyhydrylpiperazine; N-Benzhydryl-N-methyl ... Benzhydryl-N-methylpiperazine; N-Methyl-N-benzhydrylpiperazine; Nautazine; Neo-devomit; Wellcome prepn. ...
Chemical inhibition of Na/K ATPase rescues the BPA indu | Open-i
Benzhydryl Compounds/metabolism. *Environmental Pollution. *Estradiol/analogs & derivatives/pharmacology. *Female. *In Situ ... This suggests that the two compounds have opposite effects: on the one hand, BPA promotes multiplication and aggregation of ... This suggests that the two compounds have opposite effects: on the one hand, BPA promotes multiplication and aggregation of ...
BPA effect on otolith development is estrogen receptor- | Open-i
Methylenebis(chloroaniline) | Profiles RNS
Review Provides Mechanisms For Effective SGLT2i Use in Diabetes - American College of Cardiology
N-Benzhydryl-4-methylquinolin-2-amine | C23H20N2 - PubChem
Patent US5010104 - Tricyclic compounds - Google Patents
Novel tricyclic compounds having a TXA2 -antagonizing activity represented by formul (I): ##STR1## which strongly antagonize an ... which are known carbocyclics; the aralkyl, by benzyl, phenethyl and benzhydryl having 7 to 15 carbon atoms, etc.; and the ... to Compound (IXb) and Compound (IXc) and from Compound (IXb) to Compound (IXc), described in Method 1-2. ... Compound (XV) can be converted into Compound (IXg-1) [in Compound (IXg), n is 1 and Hal is chlorine] according to the following ...
US4727071A - Cephalosporin compounds
- Google Patents
Said cephalosporin compound is useful as an antimicrobial agent. ... A cephalosporin compound of the formula: ##STR1## wherein R 1 ... butyl or benzhydryl, said group or groups may be removed by treating the compound (IV) with an acid. Suitable examples of such ... the starting compound (II) may be prepared by hydrolyzing the compound (VI) to give a compound of the formula: ##STR22## ... Cephalosporin compounds and the production thereof US4952578A (en) 1990-08-28. Cephem compound and a process for preparation ...
3-Benzhydryl-1H-indole-2-carboxylic acid | C22H17NO2 - PubChem
privileged-structures
Benzhydryl - 1150 compounds. Biphenyl - 660 compounds. Aza-(and diaza-)biphenyl - 1050 compounds. Dihydropyridine - 1230 ... Compound Libraries. Natural products. Buy Compounds Online. Bioscreening Directory. Glossary. News Feeds. News. Structure ... Phenylpiperazine - 1270 compounds. You are welcome to select any number of compounds from above groups. All privileged ... Discounted price depends on the final number of compounds selected and a required samples size per compound. ...
CCCC 1969, Volume 34, Issue 12, Abstracts pp. 3792-3800, Articles by the same authors
| Collection of Czechoslovak Chemical...
Benzhydryl β-diethylaminopropionate and related compounds. 1950, Vol. 15, pp. 671-676 [Abstract] ... Neurotropic and psychotropic compounds. LV. New syntheses of 8-chloro-10-(4-methylpiperazino)-10,11-dihydrodibenzo[b,f]thiepin ... Neurotropic and psychotropic compounds. LI. 8-Acetamido- and 8-methylseleno derivatives of 10-(4-methylpiperazino)dibenzo[b,f] ... Basic benzhydryl ketones. II.. 1951, Vol. 16, pp. 151-157 [Abstract] *M. Protiva and M. Borovička. Antihistamine substances. ...
CCCC 1959, Volume 24, Issue 8, Abstracts pp. 2493-2500, Articles by the same authors
| Collection of Czechoslovak Chemical...
Benzhydryl β-diethylaminopropionate and related compounds. 1950, Vol. 15, pp. 671-676 [Abstract] ... I. N-Substituted derivatives of 5-amino-6,7,8,9-tetrahydro-5H-benzocycloheptene and some other compounds. 1971, Vol. 36, Issue ... 1-(4-Alkanesulfonylphenacyl)-4-arylpiperazines and related compounds: A new series of central depressants. 1975, Vol. 40, Issue ...
Department of Family and Community Medicine - Research Output
- Penn State
Bodsworth, N., Bloch, M., McNulty, A., Denham, I., Doong, N., Trottier, S., Adena, M., Bonney, M. A., Agnew, J., Abdurahman, I., Ajam, A., Alexander, R., Aung, A., Barry, S., Becker, B., Belbin, M., Bishop, C., Bisshop, F., Bourne, C., Brett, T. & 158 others, Brown, K., Butler, A., Carmody, C., Chan, D., Chuah, J., Conway, D., Daly, C., Davies, S., Davis, C., Davis, B., Dever, N., Donovan, B., Eisen, D., Eliades, C., Elisha, B., Fairley, C., Feiglin, A., Freeman, A., Furner, V., Garland, S., Genn, W., Giannakopoulos, J., Glass, F., Gold, J., Goswami, J., Gowers, A., Grech, J., Hackney, P., Hanson, B., Hartnell, K., Harvey, C., Hasan, M., Hawkins, S., Heley, S., Herbst, D., Hespe, C., Irlicht, M., Isaacs, A., Katahanas, L., Kelly, M., Komarowski, P., Kostic, G., Kozminsky, M., Lagios, K., Lee, D., Lewis, P., Liang, T., Lyttle, H., Mackellar-Michelmore, H., Macleod, H., Marsh, L., Marshall, L., McCloskey, J., McCurdy, D., McEvoy, P., McFarlane, R., McKeegan, P., McMurchie, M., McNamee, K., ...
Modafinil
CVD-REAL 2: SGLT-2 Inhibitors Associated With Lower Cardiovascular Risk Versus Other Glucose-Lowering Drugs - American College...
adult all tdt positive 2005:2010[pubdate] *count=100 - BioMedLib™ search engine
An investigation into the roles of synaptic vesicular Mg++-ATPase in neurotransmitter release, using benzhydryl piperazines |...
A series of benzhydryl piperazines was found to inhibit synaptic vesicular Mg++-ATPase. These compounds were also found to ... An investigation into the roles of synaptic vesicular Mg++-ATPase in neurotransmitter release, using benzhydryl piperazines. ... Synthesis and Ca-antagonist activity of some benzhydryl derivatives. (opens in new tab) ...
adenocarcinoma of cervix with metaplasia 2005:2010[pubdate] *count=100 - BioMedLib™ search engine
KR940701384A -
Azanorbornane derivatives
- Google Patents
Compounds of formula (I) are useful for the treatment of inflammatory and central nervous system diseases as well as other ... 제1항에 있어서, R1이 벤즈히드릴인 화합물.The compound of claim 1, wherein R 1 is benzhydryl. ... the corresponding compound of formula (VII) Reacted with a compound of (R 3 is as defined in claim 16) to form a compound of ... Benzoamide piperidine containing compounds and related compounds MXPA03000275A (en) 2000-07-11. 2004-12-13. Albany Molecular ...
SulfinylAbstractAdrafinilToxicityInhibitMetabolismBisphenolDiphenylmethylPhenylAromaticDerivativesPiperazinesMethyl radicalInhibitionEstrogenicChemicalPiperazineDiphenylmethaneFormulaThereofTherapeuticEstradiolCephalosporin compoundRadicalsInvention relatesClaim 10EndocrineInhibitorsPatentActive ingredientStructuresSelectivelySeriesPotentMethanePharmaceutical
Sulfinyl7
- Amido: dextromoramide Imino: benzodiazepine, GYKI-52895 Sulfinyl: modafinil, adrafinil Pituxate gem-diphenylcyclopropane These species are not strictly benzhydryl-containing but are analogous. (wikipedia.org)
- Adrafinil is a benzhydryl sulfinyl compound that was first developed in 1974. (nootriment.com)
- They developed a series of benzhydryl sulfinyl compounds, one of which was Adrafinil. (nootriment.com)
- Modafinil was first discovered because of tests on Adrafinil , a compound sulfinyl of benzhydryl that was first developed in 1974 by Lafon. (waklert.org)
- 11. The discovery of Modafinil actually came about because of the previous development of a series of benzhydryl sulfinyl compounds, including Adrafinil, in 1974. (ideasdebabel.com)
- Modafinil was discovered after the invention of a chain of other chemicals categorized as Benzhydryl Sulfinyl. (trackmystack.com)
- Modafinil originated with the late s invention of a series of benzhydryl sulfinyl compounds, including adrafinilwhich was first offered as an experimental treatment for narcolepsy in France in Oxford University Press. (volkmannchiropractic.com)
Abstract1
- Abstract Bisphenol A (BPA) is an emerging contaminant, regularly detected in aquatic ecosystems, considered as an endocrine disrupting compound (EDC). (bvsalud.org)
Adrafinil7
- Modafinil and Adrafinil are very similar compounds on a molecular level, with the only difference in structure being that Modafinil lacks a hydroxyl group the Adrafinil has on its terminal amide. (nootriment.com)
- Both Adrafinil and Modafinil are classified as eugeroic compounds, meaning they have wakefulness promoting effects. (nootriment.com)
- Armodafinil is the latest iteration in a series of related compounds that stretches back to the 1970s with the invention of Adrafinil. (nootriment.com)
- Adrafinil was not found to have any pain-relieving effects, but instead fell into a category of compounds known as eugeroics, or wakefulness promoting compounds. (nootriment.com)
- Adrafinil is therefore a prodrug, meaning it is a largely inactive compound that is broken down into and acts though the action of an active metabolite - in this case Modafinil. (nootriment.com)
- Modafinil is the essential dynamic compound in Adrafinil that causes effects in the body. (waklert.org)
- Most importantly, these included Modafinil's precursor compound Adrafinil . (trackmystack.com)
Toxicity1
- However, this single-compound approach neglects the fact that the mixture exposed to human may act additively or synergistically to induce greater toxicity than the single compounds exposure due to their similarities in the mode of action and targets. (bvsalud.org)
Inhibit7
- A series of benzhydryl piperazines was found to inhibit synaptic vesicular Mg++-ATPase. (meta.org)
- R-Q-Ar-SO 2 NH 2 are disclosed, which compounds selectively inhibit CAIX and CAXII, and which are effective to inhibit hypoxic tumor growth, suppress metastases, and impair and deplete cancer stem cells in mammals. (sparrho.com)
- In fact, among derivatives mentioned above, there are no compounds which selectively inhibit CA isoforms with therapeutic value (inhibition data of 1-25 sulfonamide compounds against all human (h) CA isoforms are provided in Supuran, C. (2008) Nature 7: 168-181. (sparrho.com)
- Compounds and compositions comprising compounds that inhibit glutaminase are described herein. (patsnap.com)
- Also described herein are methods of using the compounds that inhibit glutaminase in the treatment of cancer. (patsnap.com)
- This invention relates to pyrazole compounds that inhibit or modulate the activity of cyclin dependent kinases (CDK) and glycogen synthase kinase-3 (GSK-3), to the use of the compounds in the treatment or prophylaxis of disease states or conditions mediated by cyclin dependent kinases and glycogen synthase kinase-3, and to novel compounds having cyclin dependent kinase or glycogen synthase kinase-3 inhibitory or modulating activity. (allindianpatents.com)
- Our work illustrates the power of a system-scale analysis of transcriptional regulation to characterize potential therapeutic compounds that inhibit pathogenic Th17 cells and suppress autoimmunity. (broadinstitute.org)
Metabolism1
- These antihistamines represent a heterogenous group of compounds with differing chemical structures, adverse effects, distribution, and metabolism. (bvsalud.org)
Bisphenol1
- All tested substances were identified as agonists for human estrogen rece ptor α by methods in silico and in vitro, four substances showed a potentially higher estrogenic activity comparing to bisphenol A, two substances were identified as very weak antagonists of human androgen rece ptor and one compound showed a potential of agonistic activity to human androgen rece ptor. (nel.edu)
Diphenylmethyl1
- The diphenylmethyl group is also known as benzhydryl. (wikipedia.org)
Phenyl6
- The compound consists of methane wherein two hydrogen atoms are replaced by two phenyl groups. (wikipedia.org)
- The corrosion inhibition effect of N-(4-((4-Benzhydryl piperazin-1-yl) methyl Carbamoyl) Phenyl) Furan-2-Carboxamide (BFC) on brass in 1M HCl has been investigated using weight loss method, potentiodynamic polarization, electrochemical impedance spectroscopy (EIS), and cyclic voltammetry (CV). (hindawi.com)
- 4. A compound or the use as claimed in any one of claims 1 to 3 wherein in the compound of general formula (I) A is phenyl. (patentsencyclopedia.com)
- 13. A compound or the use as claimed in any one of claims 1 to 7 wherein, in the compound of general formula (I), R 1 and R 2 together form a heterocyclic ring system, selected from isoindoline, piperazine, piperidine, tetrahydroisoquinoline, any of which may optionally be substituted with one or more phenyl or halophenyl groups. (patentsencyclopedia.com)
- 17. A compound or the use as claimed in claim 15 wherein, in the compound of general formula (I), R 5 is a phenyl group which is optionally substituted with C 1 -C 4 alkyl, halo or NO.sub. (patentsencyclopedia.com)
- This review would take on benzylpiperazine (BZP) and trifluoromethylpiperazine (TFMPP), benzhydryl piperazine, diphenylalkyl piperazine, phenyl piperazine as the most popular member of the piperazines, focusing the discussion on their origins, pharmacokinetics and pharmacodynamics, and their effects on the human body. (ijpsr.com)
Aromatic2
- Many of the inhibitors are organic compounds containing nitrogen, oxygen, sulphur, Phosphorous, and aromatic rings that cause adsorption on the metal surface [ 2 ]. (hindawi.com)
- Benzhydryl radicals donate a hydrogen atom rapidly to the less hindered nitrogen atom of aliphatic and aromatic azo compounds, leading to the corresponding hydrazines. (rice.edu)
Derivatives2
- To identify potent and selective chemical compounds against DPP8, we have synthesized a series of isoquinoline and isoindoline derivatives and have tested their inhibitory activity against DPP8, DPP-IV and DPP-II. (uniprot.org)
- 9. The compound of claim 1, wherein said compound is selected from the group consisting of: ##STR24## and ester derivatives thereof. (google.es)
Piperazines1
- Piperazines are a broad class of chemical compounds with many important pharmacological properties. (ijpsr.com)
Methyl radical2
- Benzhydryl compounds are compounds that are " diphenylmethane "-containing, i.e. containing two benzene rings adjoining a single methyl radical . (wikipedia.org)
- Compounds which contain the methyl radical substituted with two benzene rings. (bvsalud.org)
Inhibition2
- Nowadays the synthesized Mannich base compounds have been of interest in order to obtain efficient corrosion inhibitors since they provide much greater inhibition efficiency compared to corresponding amines and aldehydes. (hindawi.com)
- Novel isoindoline compounds for potent and selective inhibition of prolyl dipeptidase DPP8. (uniprot.org)
Estrogenic2
- Studies on cells and in experimental animals have shown that both these compounds can be classified as estrogenic hormone disrupters. (arctichealth.org)
- Commercially available yeast-based microplate assay (XenoScreen YES/YAS, Xenometrix, Switzerland) for detection of compounds with estrogenic and androgenic agonistic/antagonistic activity was used as a comparative test to estrogen rece ptor transactivation assay (OECD TG 455/457) and for screening of the agonistic/antagonistic potential of human estrogen rece ptor and agonistic/antagonistic activity of tested compounds on human androgen rece ptor. (nel.edu)
Chemical1
- Also provided are pharmaceutical compositions containing the compounds and novel chemical intermediates. (allindianpatents.com)
Piperazine2
- Isoindoline with a 1-(4,4'-difluor-benzhydryl)-piperazine group at the P2 site was observed to be a very potent DPP8 inhibitor, having an IC(50) value of 14nM with at least a 2500-fold selectivity over either DPP-IV or DPP-II. (uniprot.org)
- Piperazine is a heterocyclic compound containing four carbon atoms and two nitrogen at 1 and 4 position (as called 1, 4-hexahydropyrazine). (ijpsr.com)
Diphenylmethane3
- The benzhydryl compounds are a group of organic compounds whose parent structures include diphenylmethane (which is two benzene rings connected by a single methane), with any number of attached substituents, including bridges. (wikipedia.org)
- Diphenylmethane is an organic compound with the formula (C6H5)2CH2 (often abbreviated CH 2Ph 2). (wikipedia.org)
- lb, en, organic compound, chiefly, attributive) Any organic compound containing diphenylmethane, i.e. two benzene rings adjoining a single carbon (but typically excluding heteroaromatic ring moiety, moieties). (suomienglantisanakirja.fi)
Formula8
- The present invention provides compounds of formula (I), ##STR00001## or pharmaceutically acceptable salts or solvates thereof, methods for their preparation, methods for their use, and pharmaceutical formulations comprising them. (patents.com)
- 3. A compound of general formula (I) as claimed in claim 1 or the use as claimed in claim 2, wherein the mycobacterial condition is tuberculosis. (patentsencyclopedia.com)
- 9. A compound or the use as claimed in claim 8 wherein, in the compound of general formula (I), R 1 is hydrogen, methyl or benzyl. (patentsencyclopedia.com)
- 11. A compound or the use as claimed in claim 10, wherein in the compound of general formula (I), R 2 is adamantyl. (patentsencyclopedia.com)
- In specific embodiments, the compound of Formula (I) are ureido-sulfonamides. (sparrho.com)
- and reacting the compound of the formula 3 with an anhydrous compound represented by the following formula 2 in the presence of a second base: wherein R1 is a hydrogen or an amino protecting group, R2 is a hydrogen or a carboxyl protecting group, and R3 is a hydrogen or an amino protecting group. (allindianpatents.com)
- The salt of the compound of the formula 1 refers to a salt commonly known in the field of cephalosporin antibiotics, for example a hydrate or an acid addition salt. (allindianpatents.com)
- As used herein, the term "stereospecific compound" refers to a mixed compound (e.g., compound of the formula 1 or 3) composed of a Z-isomer (or cis-isomer) and an E-isomer (or a trans-isomer) in a ratio of about 89-94% to about 6-11%, i.e., a compound composed of a Z-isomer and an E-isomer in a ratio of about 8.1-15.7:1.0. (allindianpatents.com)
Thereof9
- A pharmaceutical composition for use as an antimicrobial agent which comprises the cephalosporin compound (I) or a salt thereof as an active ingredient together with an inert carrier therefor is also provided in the present invention. (google.com)
- Korean Patent Laid-Open Publication No. 2002-69437 discloses a 4-hydroxyphenylglycine anhydride with a pivaloyl group, which is a compound useful as an intermediate for the 7-position of cefprozil, and a preparation process thereof. (allindianpatents.com)
- 3. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein o is 1 and p is 1. (patsnap.com)
- 6. The compound of claim 5 or a pharmaceutically acceptable salt thereof, wherein each R 6 is hydrogen. (patsnap.com)
- 7. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein R 1 and R 2 are the same. (patsnap.com)
- 9. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein R 1 and R 2 are each -N(R 3 )-C(O)-R 4 wherein each R 3 is hydrogen and each R 4 is aralkyl or heteroaralkyl, each of which is substituted with 0-3 occurrences of R 5 . (patsnap.com)
- A pharmaceutical composition comprising a compound of claim 1 or a pharmaceutically acceptable salt thereof. (patsnap.com)
- 19. A method of treating a cancer associated with aberrant or elevated function of glutaminase, the method comprising administering a compound of claim 1 or a pharmaceutically acceptable salt thereof to a subject in need thereof. (patsnap.com)
- 12. A pharmaceutical antimicrobial composition comprising an effective amount of a compound of claim 1 or a pharmaceutically acceptable salt thereof in association with a pharmaceutically acceptable, substantially non-toxic carrier orexcipient. (patentgenius.com)
Therapeutic1
- Novel tricyclic compounds having a TXA 2 -antagonizing activity represented by formul (I): ##STR1## which strongly antagonize an action of thromboxane A 2 and are expected to have preventive and therapeutic effects on ischemica diseases, cerebro-vascular diseases, etc. (google.com)
Estradiol1
- Two control compounds, 17β-estradiol (an estrogen receptor ligand) and GSK4716 (a synthetic estrogen-related receptor gamma ligand), were included. (oregonstate.edu)
Cephalosporin compound3
- Said cephalosporin compound is useful as an antimicrobial agent. (google.com)
- This invention relates to a novel cephalosporin compound and processes for preparing the same. (google.com)
- Therefore, the present invention provides a process for preparing a cephalosporin compound using a 3-(Z)-propenyl cephem derivative. (allindianpatents.com)
Radicals2
- Part I.~Reduction of azoalkanes by benzhydryl radicals. (rice.edu)
- Photolytic Generation of Benzhydryl Cations and Radicals from Quaternary Phosphonium Salts: How High. (biomedsearch.com)
Invention relates1
- The present invention relates to novel tricyclic compounds which strongly antagonize an action of thromboxane A 2 (hereafter referred to as TXA 2 ). (google.com)
Claim 101
- 11. The compound of claim 10, which is 7-[2-(2-amino-5-chlorothiazol-4-yl)-2-carboxymethoxyiminoacetamido]-2-meth yl-3-cephem-4-carboxylic acid (syn isomer). (patentgenius.com)
Endocrine2
- Endocrine-disrupting compounds (EDCs) have immune-modulating effects. (nih.gov)
- Screening of endocrine activity of compounds migrating from plastic baby bottles using a multi-receptor panel of in vitro bioassays. (sciensano.be)
Inhibitors3
- This afforded a series of potent orally bioavailable inhibitors of which MK-8718 was identified as a compound with a favorable overall profile. (rcsb.org)
- Even though the inhibitors of the first series only address two of the four specificity pockets, they show largely improved ligand efficiencies, with the best compound displaying a value of -0.27 kcal/mol. (uni-marburg.de)
- It is clear from this review that the use of CAIX inhibitors for cancer and metastasis has not been demonstrated effectively, due to the limitations of the compounds available. (sparrho.com)
Patent2
- U.K. Patent No. 2,135,305 discloses a process for preparing cefprozil from a 4-hydroxyphenylglycine compound with a t-butoxycarbonyl-protected amino group and a cephem compound with a benzhydryl-protected carboxyl group. (allindianpatents.com)
- In view of the above problems, Korean Patent Laid-Open Publication No. 2002-80838 discloses a process for preparing a 3-(Z)-propenyl cephem compound by reacting a phosphoranylidene cephem compound with acetaldehyde in a mixed solvent essentially consisting of ether in the presence of a base. (allindianpatents.com)
Active ingredient1
- 10. A pharmaceutical composition comprising a pharmaceutical carrier and, as an active ingredient, a therapeutically effective amount of a tricyclic compound defined in claim 1. (google.com)
Structures1
- All privileged structures are available as one large screening collection of 5660 compounds adjusted for overlap between individual groups. (timtec.net)
Selectively1
- WO93/16084 discloses a process for selectively separating a 3-(Z)-propenyl cephem compound by means of a hydrochloride, metal, or tertiary amine salt of 7-amino-3-(1-propen-1-yl)-3-cephem-carboxylic acid or by adsorption chromatography. (allindianpatents.com)
Series1
- It was one of a series of compounds related to the plant derivative ephedrine , which had been isolated from Ma-Huang that same year by Nagayoshi Nagai . (thefullwiki.org)
Potent1
- Unfortunately, these potent bicyclic compounds displayed no cellular activity. (uni-marburg.de)
Methane1
- This group typically excludes compounds in which either benzene is fused to another ring (bicyclic, tricyclic, polycyclic) or includes a heteroatom, or where the methane connects to three or four benzenes. (wikipedia.org)
Pharmaceutical1
- We do not sell or distribute the pharmaceutical compounds written about in this database. (springer.com)