Benzhydryl Compounds
Molecular Structure
Sulfur Compounds
Volatile Organic Compounds
Structure-Activity Relationship
Plant Extracts
The vigilance promoting drug modafinil increases extracellular glutamate levels in the medial preoptic area and the posterior hypothalamus of the conscious rat: prevention by local GABAA receptor blockade. (1/1043)
The effects of modafinil on glutamatergic and GABAergic transmission in the rat medial preoptic area (MPA) and posterior hypothalamus (PH), are analysed. Modafinil (30-300 mg/kg) increased glutamate and decreased GABA levels in the MPA and PH. Local perfusion with the GABAA agonist muscimol (10 microM), reduced, while the GABAA antagonist bicuculline (1 microM and 10 microM) increased glutamate levels. The modafinil (100 mg/kg)-induced increase of glutamate levels was antagonized by local perfusion with bicuculline (1 microM). When glutamate levels were increased by the local perfusion with the glutamate uptake inhibitor L-trans-PDC (0.5 mM), modafinil produced an additional enhancement of glutamate levels. Modafinil (1-33 microM) failed to affect [3H]glutamate uptake in hypothalamic synaptosomes and slices. These findings show that modafinil increases glutamate and decreases GABA levels in MPA and PH. The evidence that bicuculline counteracts the modafinil-induced increase of glutamate levels strengthens the evidence for an inhibitory GABA/glutamate interaction in the above regions controlling the sleep-wakefulness cycle. (+info)Inhibition by a coantioxidant of aortic lipoprotein lipid peroxidation and atherosclerosis in apolipoprotein E and low density lipoprotein receptor gene double knockout mice. (2/1043)
Antioxidants can inhibit atherosclerosis in animals, though it is not clear whether this is due to the inhibition of aortic lipoprotein lipid (per)oxidation. Coantioxidants inhibit radical-induced, tocopherol-mediated peroxidation of lipids in lipoproteins through elimination of tocopheroxyl radical. Here we tested the effect of the bisphenolic probucol metabolite and coantioxidant H 212/43 on atherogenesis in apolipoprotein E and low density lipoprotein (LDL) receptor gene double knockout (apoE-/-;LDLr-/-) mice, and how this related to aortic lipid (per)oxidation measured by specific HPLC analyses. Dietary supplementation with H 212/43 resulted in circulating drug levels of approximately 200 microM, increased plasma total cholesterol slightly and decreased plasma and aortic alpha-tocopherol significantly relative to age-matched control mice. Treatment with H 212/43 increased the antioxidant capacity of plasma, as indicated by prolonged inhibition of peroxyl radical-induced, ex vivo lipid peroxidation. Aortic tissue from control apoE-/-;LDLr-/- mice contained lipid hydro(pero)xides and substantial atherosclerotic lesions, both of which were decreased strongly by supplementation of the animals with H 212/43. The results show that a coantioxidant effectively inhibits in vivo lipid peroxidation and atherosclerosis in apoE-/-;LDLr-/- mice, consistent with though not proving a causal relationship between aortic lipoprotein lipid oxidation and atherosclerosis in this model of the disease. (+info)Comparative formation, distribution, and elimination kinetics of diphenylmethoxyacetic acid (a diphenhydramine metabolite) in maternal and fetal sheep. (3/1043)
Deamination to diphenylmethoxyacetic acid (DPMA) is the major route of diphenhydramine (DPHM) clearance in many species. In this study, we assessed the contribution of this pathway to nonplacental DPHM elimination and disposition of DPMA in maternal and fetal sheep. Paired maternal-fetal experiments were conducted in five chronically catheterized pregnant sheep (124-140 days gestation) with an appropriate washout period in between. Both maternal and fetal dosing experiments involved administration of an i.v bolus of deuterium-labeled DPMA ([2H10]-DPMA) combined with a 6-h infusion of DPHM (or a bolus of unlabeled DPMA with an infusion of deuterium-labeled DPHM). Maternal and fetal arterial plasma and urine samples were collected and analyzed for DPMA, [2H10]-DPMA, DPHM, and deuterium-labeled DPHM concentrations using gas chromatography-mass spectrometry. The preformed DPMA (or [2H10]-DPMA) had a substantially lower clearance (maternal: 0.55 +/- 0.18 versus 40.9 +/- 14.0 ml/min/kg; fetal: 0.37 +/- 0.11 versus 285. 6 +/- 122.2 ml/min/kg) and steady-state volume of distribution (Vdss, maternal: 0.10 +/- 0.02 versus 2.1 +/- 1.1 l/kg; fetal: 0.40 +/- 0. 06 versus 13.1 +/- 3.1 l/kg) as compared with the parent drug. The contribution of DPMA formation to maternal and fetal DPHM nonplacental clearance in vivo was 1.78 +/- 2.12% and 0.87 +/- 0.56%, respectively, indicating that DPMA formation is not a major route of DPHM clearance in fetal or maternal sheep. The recoveries of DPMA (or [2H10]-DPMA) in maternal urine were 88.0 +/- 6.5 and 92.1 +/- 7. 4% of the administered dose during maternal and fetal dosing experiments, respectively. Thus, this metabolite does not appear to be secondarily metabolized in fetal or maternal sheep. These findings are in contrast to other species (dog, rhesus monkey, human) where DPMA and its conjugates constitute approximately 40 to 60% of the total DPHM metabolites. (+info)Tolterodine does not affect the human in vivo metabolism of the probe drugs caffeine, debrisoquine and omeprazole. (4/1043)
AIM: To investigate the in vivo effect of treatment with tolterodine on debrisoquine 4-hydroxylation (an index of CYP2D6 activity), omeprazole 5-hydroxylation (CYP2C19), omeprazole sulphoxidation (CYP3A4) and caffeine N3-demethylation (CYP1A2). METHODS: Twelve healthy male volunteers (eight extensive metabolisers [EMs] and four poor metabolisers [PMs] with respect to CYP2D6) received 4 mg tolterodine L-tartrate orally twice daily for 6 days. All subjects were EMs with respect to CYP2C19. The subjects received single oral doses of debrisoquine (10 mg), omeprazole (20 mg) and caffeine (100 mg) for determination of the appropriate metabolic ratios (MR). The drugs were given on separate consecutive days, before, during and after the co-administration of tolterodine. RESULTS: Mean serum tolterodine concentrations were 5-10 times higher in PMs than in EMs. Serum concentrations of the active 5-hydroxymethyl metabolite of tolterodine, 5-HM, were not quantifiable in PMs. The mean MR of debrisoquine (95% confidence interval) during tolterodine treatment was 0.50 (0.25-0.99) and did not differ statistically from the values before [0.49 (0.20-1.2)] and after tolterodine administration [0.46 (0.14-1.6)] in EMs. The mean MR of omeprazole hydroxylation and sulphoxidation or caffeine metabolism were not changed in the presence of tolterodine in either EMs or PMs. Debrisoquine and caffeine had no significant effect on the AUC(1,3 h) of either tolterodine or 5-HM, but during omeprazole administration small decreases (13-19%) in these parameters were seen. CONCLUSIONS: Tolterodine, administered at twice the expected therapeutic dosage, did not change the disposition of the probe drugs debrisoquine, omeprazole and caffeine and thus had no detectable effect on the activities of CYPs 2D6, 2C19, 3A4 and 1A2. Alteration of the metabolism of substrates of these enzymes by tolterodine is unlikely to occur. (+info)Effect of neonatal exposure to estrogenic compounds on development of the excurrent ducts of the rat testis through puberty to adulthood. (5/1043)
Neonatal exposure to diethylstilbestrol (DES) can alter the structure of the testicular excurrent ducts in rats. We characterized these changes according to dose and time posttreatment and established whether potent estrogens (ethinyl estradiol), environmental estrogens (genistein, octylphenol, bisphenol A, parabens), and tamoxifen induce such changes. Rats were administered these compounds neonatally and assessed at several time points during (day 10, or day 18 for some treatments) and after (days 18, 25, 35, and 75) the treatment period to detect any changes in testis weight, distension of the rete testis and efferent ducts, epithelial cell height in the efferent ducts, and immunoexpression of the water channel aquaporin-1 (AQP-1). Treatment with DES (10, 1, or 0.1 microg/injection; equivalent to 0.37, 0.037, or 0.0037 mg/kg/day, respectively) induced dose-dependent changes in testis weight and all parameters. These effects were most pronounced at days 18 and 25 and appeared to lessen with time, although some persisted into adulthood. Neonatal treatment with ethinyl estradiol (10 microg/injection; equivalent to 0.37 mg/kg/day) caused changes broadly similar to those induced by 10 mg DES. Administration of tamoxifen (2 mg/kg/day) caused changes at 18 days that were similar to those induced by 1 microg DES. Treatment with genistein (4 mg/kg/day), octylphenol (2 mg/injection; equivalent to 150 mg/kg/day), or bisphenol A (0.5 mg/injection; equivalent to 37 mg/kg/day) caused minor but significant (p<0.05) decreases in epithelial cell height of the efferent ducts at days 18 and/or 25. In animals that were followed through to 35 days and/or adulthood, these changes were no longer obvious; other parameters were either unaffected or were affected only marginally and transiently. Administration of parabens (2 mg/kg/day) had no detectable effect on any parameter at day 18. To establish whether these effects of estrogens were direct or indirect (i.e., resulting from reduced follicle-stimulating hormone/luteinizing hormone secretion), the above end points were assessed in animals in which gonadotropin secretion was suppressed neonatally by administration of a gonadotropin-releasing hormone antagonist. This treatment permanently reduced testis weight, but did not affect any of the other end points, apart from a minor transient reduction in efferent duct epithelial cell height at 18 days. This study suggests that structural and functional (expression of AQP-1) development of the excurrent ducts is susceptible to impairment by neonatal estrogen exposure, probably as a consequence of direct effects. The magnitude and duration of adverse changes induced by treatment with a range of estrogenic compounds was broadly comparable to their estrogenic potencies reported from in vitro assays. (+info)Glucuronidation of the environmental oestrogen bisphenol A by an isoform of UDP-glucuronosyltransferase, UGT2B1, in the rat liver. (6/1043)
Bisphenol A, an environmental oestrogenic chemical, was found to conjugate highly with glucuronic acid in male rat liver microsomes studied in vitro. In the various isoforms tested (1A1, 1A3, 1A5, 1A6, 1A7 and 2B1), glucuronidation of bisphenol A and of diethylstilboestrol, a synthetic crystalline compound possessing oestrogenic activity and known to be glucuronidated by liver microsomes, was catalysed by an isoform of UDP-glucuronosyltransferase (UGT), namely UGT2B1, which glucuronidates some endogenous androgens. UGT activity towards bisphenol A in liver microsomes and in UGT2B1 expressed in yeast AH22 cells (22.9 and 0.58 nmol/min per mg of microsomal proteins respectively) was higher than that towards diethylstilboestrol (75.0 and 4.66 pmol/min per mg of microsomal proteins respectively). UGT activities towards both bisphenol A and diethylstilboestrol were distributed mainly in the liver but were also observed at substantial levels in the kidney and testis. Northern blot analysis disclosed the presence of UGT2B1 solely in the liver, and about 65% of the male rat liver microsomal UGT activities towards bisphenol A were absorbed by the anti-UGT2B1 antibody. These results indicate that bisphenol A, in male rat liver, is glucuronidated by UGT2B1, an isoform of UGT. (+info)UK-78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage-gated potassium channel and inhibits human T cell activation. (7/1043)
1. UK-78,282, a novel piperidine blocker of the T lymphocyte voltage-gated K+ channel, Kv1.3, was discovered by screening a large compound file using a high-throughput 86Rb efflux assay. This compound blocks Kv1.3 with a IC50 of approximately 200 nM and 1:1 stoichiometry. A closely related compound, CP-190,325, containing a benzyl moiety in place of the benzhydryl in UK-78,282, is significantly less potent. 2 Three lines of evidence indicate that UK-78,282 inhibits Kv1.3 in a use-dependent manner by preferentially blocking and binding to the C-type inactivated state of the channel. Increasing the fraction of inactivated channels by holding the membrane potential at - 50 mV enhances the channel's sensitivity to UK-78,282. Decreasing the number of inactivated channels by exposure to approximately 160 mM external K+ decreases the sensitivity to UK-78,282. Mutations that alter the rate of C-type inactivation also change the channel's sensitivity to UK-78,282 and there is a direct correlation between tau(h) and IC50 values. 3. Competition experiments suggest that UK-78,282 binds to residues at the inner surface of the channel overlapping the site of action of verapamil. Internal tetraethylammonium and external charybdotoxin do not compete UK-78,282's action on the channel. 4. UK-78,282 displays marked selectivity for Kv1.3 over several other closely related K+ channels, the only exception being the rapidly inactivating voltage-gated K+ channel, Kv1.4. 5. UK-78,282 effectively suppresses human T-lymphocyte activation. (+info)Functional magnetic resonance imaging neuroactivation studies in normal subjects and subjects with the narcoleptic syndrome. Actions of modafinil. (8/1043)
Functional magnetic resonance imaging (fMRI) can be used to detect regional brain responses to changes in sensory stimuli. We have used fMRI to determine the amount of visual and auditory cortical activation in 12 normal subjects and 12 subjects with the narcoleptic syndrome, using a multiplexed visual and auditory stimulation paradigm. In both normal and narcoleptic subjects, mean cortical activation levels during the presentation of periodic visual and auditory stimulation showed no appreciable differences with either age or sex. Normal subjects showed higher levels of visual activation at 10:00 hours than 15:00 hours, with a reverse pattern in narcoleptic subjects (P = 0.007). The group differences in spatial extent of cortical activation between control and narcoleptic subjects were small and statistically insignificant. The alerting action, and imaging response, to a single oral dose of the sleep-preventing drug modafinil 400 mg were then determined and compared with placebo in both the 12 normal (8 given modafinil, 4 placebo) and 12 narcoleptic subjects (8 modafinil, 4 placebo). Modafinil caused an increase in self-reported levels of alertness in 7 of 8 narcoleptic subjects, but there was no significant difference between mean pretreatment and post-treatment activation levels as determined by fMRI for either normal or narcoleptic syndrome subjects given modafinil. However, in the modafinil-treated group of 8 normal and 8 narcoleptic subjects, there was a clock time independent correlation between the initial level of activation as determined by the pretreatment scan and the post-treatment change in activation (visual, P = 0.002; and auditory, P = 0.001). No correlation was observed in placebo-treated subjects (P = 0.99 and 0.77, respectively). Although limited by the small number of subjects, and the lack of an objective measure of alertness, the findings of this study suggest that low cortical activation levels in both normal and narcoleptic subjects are increased following the administration of modafinil. Functional magnetic resonance imaging may be a valuable addition to established studies of attention. (+info)
Benzhydryl compounds
The benzhydryl compounds are a group of organic compounds whose parent structures include diphenylmethane (which is two benzene ... U.S. Patent 4,022,786 Benzhydryl+Compounds at the US National Library of Medicine Medical Subject Headings (MeSH) ... tyrima Olanzapine Benzhydryl Compounds at the US National Library of Medicine Medical Subject Headings (MeSH) "Abbreviations ... not called benzhydryl bromide (Articles with short description, Short description is different from Wikidata, Benzhydryl ...
Diphenylmethane
Benzhydryl compounds, Benzyl compounds, All stub articles, Hydrocarbon stubs). ... C6H5)2CH− + CH3CH2CH2CH2Br → (C6H5)2CHCH2CH2CH2CH3 + Br− Alkylation of various benzhydryl compounds has been demonstrated using ... Diphenylmethane is an organic compound with the formula (C6H5)2CH2 (often abbreviated CH 2Ph 2). The compound consists of ... Benzhydryl compounds Toluene, a.k.a. methylbenzene, phenylmethane Triphenylmethane Tetraphenylmethane International Union of ...
1,1-Diphenylacetone
... is an organic compound composed of a benzhydryl group and a methyl group attached to a central carbonyl ... Benzhydryl compounds, All stub articles, Ketone stubs). ...
Modafinil
... originated with the 1970s invention of a series of benzhydryl sulfinyl compounds, including adrafinil, which was ... Benzhydryl compounds, D2-receptor agonists, Dopamine reuptake inhibitors, Drugs with unknown mechanisms of action, Nootropics, ... It is also a schedule IV compound. Krishnan R, Chary KV (2015). "A rare case modafinil dependence". Journal of Pharmacology & ... Billiard M, Lubin S (2015). "Modafinil: Development and Use of the Compound". Sleep Medicine. New York, NY: Springer New York. ...
Budipine
Tert-butyl compounds, Benzhydryl compounds, All stub articles, Nervous system drug stubs). ...
Modafinil sulfone
Benzhydryl compounds, Human drug metabolites, Sulfones, All stub articles, Nervous system drug stubs). ...
Benzilic acid
Benzhydryl compounds, Acetic acids). ... Benzilic acid is an organic compound with formula C 14H 12O 3 ...
Fexofenadine
Benzhydryl compounds, Carboxylic acids, Diols, H1 receptor antagonists, Peripherally selective drugs, Piperidines, Sanofi, ...
Dextromoramide
Benzhydryl compounds). ... was by far the most potent out of all the compounds in this ... Dextromoramide was discovered during the course of research into a related family of compounds, the α,α-Diphenyl-γ-Dialkyamino- ...
Etifelmine
Benzhydryl compounds, All stub articles, Nervous system drug stubs). ...
Phenadoxone
Benzhydryl compounds). ...
Dipipanone
Benzhydryl compounds). ... Other related compounds with equivalent activity where the ... Related compounds with an isoquinuclidine ring such as nufenoxole are also known. Prescription of dipipanone is discouraged ... along with other older compounds such as pethidine and pentazocine with unusual abuse patterns. The combination with cyclizine ...
Tolterodine
Benzhydryl compounds, Diisopropylamino compounds, Muscarinic antagonists, Pfizer brands, Phenols, Wikipedia medicine articles ...
Desoxypipradrol
Benzhydryl compounds). ... is a short-acting compound, as it possesses a methyl-ester ... "A Change to the Misuse of Drugs Act 1971: control of pipradrol-related compounds and phenazepam". UK Home Office. 7 June 2012. ... Desoxypipradrol is closely related on a structural level to the compounds methylphenidate and pipradrol, all three of which ...
Diphenylketene
Benzhydryl compounds, Ketenes). ... The compound is easily oxidized by air but can be stored in ... With carbonyl compounds β-lactones are formed analogously. The [2+2]cycloaddition of diphenyl ketene with phenylacetylene leads ... 2619-2624, doi:10.1021/ja01265a015 (CS1 German-language sources (de), Chemical articles with multiple compound IDs, Multiple ...
Pridinol
Benzhydryl compounds, All stub articles, Musculoskeletal system drug stubs). ...
Bifemelane
Benzhydryl compounds, All stub articles, Nervous system drug stubs). ...
Diphenylprolinol
Benzhydryl compounds). ...
4,4'-Bis(dimethylamino)benzhydrol
Dimethylamino compounds, Secondary alcohols, Benzhydryl compounds). ... The compound is notable as the reduced derivative of Michler's ketone. It is a precursor to triarylmethane dyes. Muthyala, ... 4,4′-Bis(dimethylamino)benzhydrol is an organic compound with the formula (Me2NC6H4)2CH(OH), where Me is methyl. It is a white ...
Phenyltoloxamine
Dimethylamino compounds, H1 receptor antagonists, Muscarinic antagonists, Phenol ethers, Benzhydryl compounds). ...
Beta-Phenylmethamphetamine
Benzhydryl compounds). ... isopropyl-N-methylamine and related compounds". Journal of the ...
Terfenadine
Benzhydryl compounds, German inventions, H1 receptor antagonists, Hepatotoxins, HERG blocker, Peripherally selective drugs, ...
2-Diphenylmethylpyrrolidine
Benzhydryl compounds). ... control of pipradrol-related compounds and phenazepam". UK Home ...
Pipradrol
Benzhydryl compounds). ... It is now an obscure compound that is virtually unknown as an ...
Methadone
Benzhydryl compounds, Dimethylamino compounds, Drug rehabilitation, Eli Lilly and Company brands, Euphoriants, HERG blocker, ... On a new class of spasmolytic and analgesic compounds, I]. Justus Liebigs Annalen der Chemie (in German). 561 (1): 52-86. doi: ... About a new class of compounds with a spasmolytic and analgesic effect). Vol. 561. Justus Liebigs Ann. p. 561, 52-85. Defalque ...
Darifenacin
Benzhydryl compounds). ...
Tolpropamine
Benzhydryl compounds, All stub articles, Dermatologic drug stubs). ...
3,3-Diphenylcyclobutanamine
Benzhydryl compounds). ... The N-methyl and N,N-dimethyl analogues of the compound are ...
Diphenylmethylpiperazine
Benzhydryl compounds, All stub articles, Organic compound stubs). ... It features a piperazine ring with a benzhydryl (diphenylmethyl) group bound to one of the nitrogens. Calderon SN. Nonpeptidic ... 1-(Diphenylmethyl)piperazine, also known as benzhydrylpiperazine, is a chemical compound and piperazine derivative. ...
3-Benzhydrylmorpholine
Benzhydryl compounds, All stub articles, Nervous system drug stubs). ...
Leonidas Zervas
In his attempts he introduced new mercaptan protecting groups (e.g. trityl, benzhydryl or benzoyl), which finally made it ... On the Aldehyde Compounds of Amino Acids Katsoyannis, P. G., ed. (1973). The Chemistry of Polypeptides. New York: Plenum Press ...
Hydrogen-bond catalysis
For example, in a typical acyl substitution reaction, the starting carbonyl compound is coordinated to the catalyst through one ... the formation of the Strecker product from benzhydryl amines and aqueous HCN. Hydrolysis of the nitrile and deprotections ... Furthermore, analogous reactions involving oxyanion intermediates such as enolate addition to nitroso compounds or opening of ... In addition, aza-Friedel-Crafts reactions of furans, amidoalkylations of diazocarbonyl compounds, asymmetric ...
JNJ-7925476
The compounds as depicted have the carbon of the pyrrolidine carbon and the phenyl cis, but Maryanoff and coworkers are of the ... The structure is a pyrroloisoquinoline core, with an overlaid benzhydryl motif. Incorporating the pyrrolidino ring onto the ... opinion that the compound is trans. (see abstract) The reason for this is not known because it was referred to as "cis" in ...
Medrylamine
US 2668856, Morren H, "P-methoxy benzhydryl ethers", issued 1954, assigned to UCB SA. Wolff ME (1995). Burger's Medicinal ... Dimethylamino compounds, Ethers, H1 receptor antagonists, Muscarinic antagonists, Muscle relaxants, All stub articles, Nervous ...
List of MeSH codes (D02)
... benzhydryl compounds MeSH D02.455.426.559.389.115.250 - diphenhydramine MeSH D02.455.426.559.389.115.250.250 - dimenhydrinate ... trialkyltin compounds MeSH D02.691.850.900.910 - triethyltin compounds MeSH D02.691.850.900.950 - trimethyltin compounds MeSH ... mustard compounds MeSH D02.455.526.728.468 - mustard gas MeSH D02.455.526.728.650 - nitrogen mustard compounds MeSH D02.455. ... trimethyl ammonium compounds MeSH D02.092.877.883.077 - betaine MeSH D02.092.877.883.088 - bethanechol compounds MeSH D02.092. ...
NK1 receptor antagonist
The compound CP-99994 was synthesized by replacing the quinuclidine ring with a piperidine ring and benzhydryl moiety by a ... Many compounds have been described by various pharmaceutical companies besides the compounds that led to the discovery of ... However, these compounds, like most peptide compounds, had problems with selectivity, potency, solubility and bioavailability. ... This compound showed good activity in vivo and in models of pain and was developed up to phase II for the treatment of ...
Iphigenia Photaki
... benzhydryl or benzoyl groups (as part of the greater effort for the synthesis of asymmetric cysteine-containing peptides), N- ... Symposium on Natural Sulfur Compounds (Copenhagen, 1966), NATO Seminar of Molecular Biology (Spetses, 1966), 8th EPS (Noordwijk ...
Katarína Horáková
Benzhydryl- and cinamoylisothiocyanates". Neoplasma. 16 (6): 591-6. PMID 5369024. Horáková, K; Drobnica, L; Nemec, P; Uher, M ( ... Horáková, K. (1981). "The Use of Cell Cultures to Monitor the Toxic and Mutagenic Activity of Chemical Compounds Present in ... Horáková, K. (1967). "A Study of synergism of known metabolic inhibitors and antifungal compounds on Candida albicans Pn 10". ... Horáková, K; Drobnica, L; Nemec, P (1969). "Cytotoxic and cancerostatic effects of isothiocyanates and related compounds. IV. ...
DeCS
Benzhydryl Compounds - Preferred Concept UI. M0002345. Scope note. Compounds which contain the methyl radical substituted with ... Compounds which contain the methyl radical substituted with two benzene rings. Permitted are any substituents, but ring fusion ... Compounds, Benzhydryl. Compounds, Diphenylmethyl. Diphenylmethyl Compounds. Tree number(s):. D02.455.426.559.389.115. ...
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PRIME PubMed | A study of the preparation and reactivity of potassium ferrate
Benzhydryl CompoundsEndocrine DisruptorsHydrogen-Ion ConcentrationIron CompoundsPhenolsPotassium CompoundsWater Pollutants, ... a known endocrine disrupter compound, was also investigated with a molar ratio of Fe(VI):BPA in the range of 1:1-5:1. The ... a known endocrine disrupter compound, was also investigated with a molar ratio of Fe(VI):BPA in the range of 1:1-5:1. The ...
CCCC 1950, Volume 15, Issue 0, Abstracts pp. 937-945, Articles by the same authors | Collection of Czechoslovak Chemical...
Reactivity of compounds of diphenylmethane series. VI. Hydrolysis of benzhydryl bromides in 80% acetone; Cumulative effect of ... Reactivity of organic azo-compounds. X. NMR study on azo-hydrazone tautomeric equilibrium in hydroxyazo-compounds. 1970, Vol. ... Identification of organic compounds. VIII. Microidentification of alkyl halides, O-alkyl and N-alkyl groups by paper ... On the rearrangement of aromatic hydrazo compounds. V. Effect of temperature, medium and salt concentration on the kinetics of ...
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Phenylephrine (definition)
Nitrobenzenes | Profiles RNS
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... benzhydryl compounds (1) benzodioxoles (1) beta-glucosidase (1) betacoronavirus (1) biodiversity (1) bone neoplasms (1) brain ( ... 1) brain stem (1) cadmium (1) cadmium compounds (1) calcium (1) carbamates (1) carbon isotopes (1) carbon-13 magnetic resonance ... and Identification of Compounds with Multidrug Resistance (MDR) Reversal Activities. Publication Type: Academic Journal ... and six other known compounds ( 4 - 9 ) were isolated from the poisonous mushroom Chlorophyllum molybdites (Agaricaceae). The ...
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Compound 1 showed an intense absorption band at λabs= 402 nm unlike compounds 2-4 which showed λabs at 389 and 371, 400, 404 ... As they chose benzhydryl phenyl sulfone (1a) as a model substrate for their optimization, they reported the formation of the ... Compounds containing carbon-boron bonds are of high significance because they can be used as the precursors for various ... The fluorescence spectra of compound 1 showed an intense deep blue emission with a full width at half maximum (FWHM) of 27 nm ...
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This behavior stands in contrast to a homologue ABA amphiphile consisting of a central poly(2-benzhydryl-2-oxazoline) block ( ... Polymer micelles are an attractive means to solubilize water insoluble compounds such as drugs. Drug loading, formulations ... Here, polymers containing poly(2- benzhydryl-2-oxazine) (pBhOzi) repeating units are described for the first time. The ... ABA Type Amphiphiles with Poly(2-benzhydryl-2-oxazine) Moieties: Synthesis, Characterization and Inverse Thermogelation (2021) ...
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Flutriafol - Kingtai Chemicals Co., Ltd. herbicide,Insecticide,fungicide
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Efficacy and safety of dapagliflozin in acute heart failure: Rationale and design of the DICTATE-AHF trial - PubMed
Sodium glucose co-transporter 2 inhibitors and their mechanism for improving glycemia in patients with type 2 diabetes - PubMed
DailyMed - CLEMASTINE FUMARATE tablet
Clemastine belongs to the benzhydryl ether group of antihistaminic compounds. The chemical name is (+)-(2R)-2-[2-[[(R)-p-Chloro ... Antihistaminic Compounds. It should be noted that the following reactions have occurred with one or more antihistamines and, ... Pharmacokinetic studies in man utilizing 3H and 14C labeled compound demonstrates that: clemastine is rapidly and nearly ...
Betaxolol Hydrochloride|N0000004400
Spiro Compounds,N0000007532, Manganese Compounds,N0000007531, Anthracyclines,N0000007530, Macrolides,N0000007529, Benzhydryl ... Magnesium Compounds,N0000007803, Iodine Compounds,N0000007802, Fluorine Compounds,N0000007801, Calcium Compounds,N0000007800, ... Heterocyclic Compounds with 4 or More Rings,N0000008261, Heterocyclic Compounds, 2-Ring,N0000008260, Heterocyclic Compounds, 1- ... Selenium Compounds,N0000007943, Silver Compounds,N0000007942, Lithium Compounds,N0000007941, Terpenes,N0000007940, Gallium, ...
MeSH Browser
Benzhydryl Compounds Preferred Concept UI. M0002345. Registry Number. 0. Scope Note. Compounds which contain the methyl radical ... Benzhydryl Compounds [D02.455.426.559.389.115] * Diphenhydramine [D02.455.426.559.389.115.250] * Meclizine [D02.455.426.559. ... Benzhydryl Compounds Preferred Term Term UI T004527. Date01/01/1999. LexicalTag NON. ThesaurusID NLM (1975). ... BENZHYDRYL CPDS. Entry Term(s). Diphenylmethyl Compounds Registry Number. 0. Previous Indexing. Benzene Derivatives (1968-1974) ...
MeSH Browser
Benzhydryl Compounds Preferred Concept UI. M0002345. Registry Number. 0. Scope Note. Compounds which contain the methyl radical ... Benzhydryl Compounds [D02.455.426.559.389.115] * Diphenhydramine [D02.455.426.559.389.115.250] * Meclizine [D02.455.426.559. ... Benzhydryl Compounds Preferred Term Term UI T004527. Date01/01/1999. LexicalTag NON. ThesaurusID NLM (1975). ... BENZHYDRYL CPDS. Entry Term(s). Diphenylmethyl Compounds Registry Number. 0. Previous Indexing. Benzene Derivatives (1968-1974) ...
DeCS
µ
... benzhydryl compound benzhydryl compounds benzhydrylpiperazine benzhydryl piperazine benzhydrylpiperazines benzhydryl ... azocasein azocene azocine azocines azocoll azocompound azo compound azo-compound azocompounds azo compounds azo-compounds ... atrox batroxobin batroxobins bats batsman batsmen Batson Batsons Batsons compound Batsons compounds Batsons plexus Batsons ... malaria Algiers algin algin acid alginase alginate alginates alginic alginic acid alginic acid compound alginic acid compounds ...
MH - 17 alpha-Hydroxyprogesterone Caproate
HN - 2019 (1986) MH - Modafinil UI - D000077408 MN - D2.455.426.559.389.115.550 MS - A benzhydryl acetamide compound, central ... Extracellular matrix formed by secreted polymeric organic compounds by microorganisms. This secreted compound is mostly ... HN - 2019 MH - Aluminum Chloride UI - D000077410 MN - D1.56.31 MN - D1.210.450.150.25 MS - A compound with the chemical formula ... HN - 2019 (1998) MH - Arsenic Trioxide UI - D000077237 MN - D1.75.38 MN - D1.650.550.125 MS - An inorganic compound with the ...
Maternal Urinary Bisphenol A during Pregnancy and Maternal and Neonatal Thyroid Function in the CHAMACOS Study
Mutagenicity testing of 9-N-substituted adenines and their N-oxidation products. | Environmental Health Perspectives | Vol. 101...
9-benzhydryl, and 9-trityl were tested against Salmonella typhimurium strains TA97, TA98, and TA100 in the abse... ... This compound was inactive toward TA98 in the absence of S9. The results generally support the concept that nuclear N-oxidation ... Adenine together with certain 9-N-substituted derivatives such as 9-methyl, 9-benzyl, 9-benzhydryl, and 9-trityl were tested ... All compounds were positive toward TA98 in the presence of the metabolic activating system, whereas they all lacked mutagenic ...
Abstract for TR-355
No compound-related histopathological effects were observed in mice.. Based on the mortality and body weight effects of ... beta-dimethylaminoethyl benzhydryl ether hydrochloride; benzhydramine hydrochloride Report Date: September 1989 ... At no site were the incidences of neoplastic lesions in dosed mice considered to be compound related. Cytoplasmic vacuolization ...
Pesquisa | Biblioteca Virtual em Saúde - BRASIL
Compound 9 were also shown to be photostable, non-cytotoxic at concentrations up to 50 µM when tested on five cell lines, and ... The aim of this study was to design and synthesize two new series of pyrrolidine-2,5-dione-acetamides with a benzhydryl or sec- ... The study identified compound 27 that behaves as an inverse agonist of the 5-HT6R at the Gs and Cdk5 signaling pathways. ... Both compounds did not markedly enhance the frequency of micronuclei in CHO-K1 cells in the micronucleus assay. Preliminary in ...
Series2
- Reactivity of compounds of diphenylmethane series. (cas.cz)
- Modafinil was first created in France alongside a series of benzhydryl sulfinyl compounds, including adrafinil, in the late 1970s. (modafinil.org)
Ether1
- Clemastine belongs to the benzhydryl ether group of antihistaminic compounds. (nih.gov)