DiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesTechnology, Industry, AgricultureInformation ScienceHealth Care
BenzbromaroneUricosuric AgentsOxypurinolGout SuppressantsUric AcidSulfinpyrazoneGoutFlurbiprofenHyperuricemiaAllopurinolProbenecidPyrazinamideOrganic Cation Transport ProteinsOrganic Anion TransportersDrug-Induced Liver InjuryNaphthyridinesCatecholsDirectly Observed TherapyTreatment OutcomePubMedSolutionsXanthine OxidaseUrate OxidaseCalciphylaxisThiosulfatesProtective DevicesGangreneWarfarinDiagnostic Techniques and ProceduresNecrosisCoproporphyria, HereditaryCoproporphyrinsCoproporphyrinogen OxidasePorphyrias, HepaticPorphyriasPorphyrinsPorphyrinogensPhysician-Patient RelationsInjections, IntravenousPhytotherapyDrugs, Chinese HerbalUniversal PrecautionsMolecular Sequence Data
Benzbromarone
Uricosuric that acts by increasing uric acid clearance. It is used in the treatment of gout.
Uricosuric Agents
Gout suppressants that act directly on the renal tubule to increase the excretion of uric acid, thus reducing its concentrations in plasma.
Oxypurinol
A xanthine oxidase inhibitor.
Gout Suppressants
Agents that increase uric acid excretion by the kidney (URICOSURIC AGENTS), decrease uric acid production (antihyperuricemics), or alleviate the pain and inflammation of acute attacks of gout.
Uric Acid
An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
Sulfinpyrazone
A uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties.
Gout
Hereditary metabolic disorder characterized by recurrent acute arthritis, hyperuricemia and deposition of sodium urate in and around the joints, sometimes with formation of uric acid calculi.
Flurbiprofen
An anti-inflammatory analgesic and antipyretic of the phenylalkynoic acid series. It has been shown to reduce bone resorption in periodontal disease by inhibiting CARBONIC ANHYDRASE.
Hyperuricemia
Excessive URIC ACID or urate in blood as defined by its solubility in plasma at 37 degrees C; greater than 0.42mmol per liter (7.0mg/dL) in men or 0.36mmol per liter (6.0mg/dL) in women. This condition is caused by overproduction of uric acid or impaired renal clearance. Hyperuricemia can be acquired, drug-induced or genetically determined (LESCH-NYHAN SYNDROME). It is associated with HYPERTENSION and GOUT.
Allopurinol
A XANTHINE OXIDASE inhibitor that decreases URIC ACID production. It also acts as an antimetabolite on some simpler organisms.
Probenecid
The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
Pyrazinamide
A pyrazine that is used therapeutically as an antitubercular agent.
Organic Cation Transport Proteins
A family of proteins involved in the transport of organic cations. They play an important role in the elimination of a variety of endogenous substances, xenobiotics, and their metabolites from the body.
Organic Anion Transporters
Proteins involved in the transport of organic anions. They play an important role in the elimination of a variety of endogenous substances, xenobiotics and their metabolites from the body.
Drug-Induced Liver Injury
A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, and chemicals from the environment.
Naphthyridines
Catechols
A group of 1,2-benzenediols that contain the general formula R-C6H5O2.
Directly Observed Therapy
A treatment method in which patients are under direct observation when they take their medication or receive their treatment. This method is designed to reduce the risk of treatment interruption and to ensure patient compliance.
Treatment Outcome
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
PubMed
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
Solutions
The homogeneous mixtures formed by the mixing of a solid, liquid, or gaseous substance (solute) with a liquid (the solvent), from which the dissolved substances can be recovered by physical processes. (From Grant & Hackh's Chemical Dictionary, 5th ed)
Xanthine Oxidase
An iron-molybdenum flavoprotein containing FLAVIN-ADENINE DINUCLEOTIDE that oxidizes hypoxanthine, some other purines and pterins, and aldehydes. Deficiency of the enzyme, an autosomal recessive trait, causes xanthinuria.
Urate Oxidase
An enzyme that catalyzes the conversion of urate and unidentified products. It is a copper protein. The initial products decompose to form allantoin. EC 1.7.3.3.
Calciphylaxis
Condition of induced systemic hypersensitivity in which tissues respond to appropriate challenging agents with a sudden local calcification.
Thiosulfates
Inorganic salts of thiosulfuric acid possessing the general formula R2S2O3.
Protective Devices
Devices designed to provide personal protection against injury to individuals exposed to hazards in industry, sports, aviation, or daily activities.
Gangrene
Death and putrefaction of tissue usually due to a loss of blood supply.
Warfarin
An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.
Diagnostic Techniques and Procedures
Methods, procedures, and tests performed to diagnose disease, disordered function, or disability.
Necrosis
The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrolled action of degradative ENZYMES, leading to MITOCHONDRIAL SWELLING, nuclear flocculation, and cell lysis. It is distinct it from APOPTOSIS, which is a normal, regulated cellular process.
Coproporphyria, Hereditary
An autosomal dominant porphyria that is due to a deficiency of COPROPORPHYRINOGEN OXIDASE in the LIVER, the sixth enzyme in the 8-enzyme biosynthetic pathway of HEME. Clinical features include both neurological symptoms and cutaneous lesions. Patients excrete increased levels of porphyrin precursors, 5-AMINOLEVULINATE and COPROPORPHYRINS.
Coproporphyrins
Porphyrins with four methyl and four propionic acid side chains attached to the pyrrole rings. Elevated levels of Coproporphyrin III in the urine and feces are major findings in patients with HEREDITARY COPROPORPHYRIA.
Coproporphyrinogen Oxidase
An enzyme that catalyzes the oxidative decarboxylation of coproporphyrinogen III to protoporphyrinogen IX by the conversion of two propionate groups to two vinyl groups. It is the sixth enzyme in the 8-enzyme biosynthetic pathway of HEME, and is encoded by CPO gene. Mutations of CPO gene result in HEREDITARY COPROPORPHYRIA.
Porphyrias, Hepatic
A group of metabolic diseases due to deficiency of one of a number of LIVER enzymes in the biosynthetic pathway of HEME. They are characterized by the accumulation and increased excretion of PORPHYRINS or its precursors. Clinical features include neurological symptoms (PORPHYRIA, ACUTE INTERMITTENT), cutaneous lesions due to photosensitivity (PORPHYRIA CUTANEA TARDA), or both (HEREDITARY COPROPORPHYRIA). Hepatic porphyrias can be hereditary or acquired as a result of toxicity to the hepatic tissues.
Porphyrias
A diverse group of metabolic diseases characterized by errors in the biosynthetic pathway of HEME in the LIVER, the BONE MARROW, or both. They are classified by the deficiency of specific enzymes, the tissue site of enzyme defect, or the clinical features that include neurological (acute) or cutaneous (skin lesions). Porphyrias can be hereditary or acquired as a result of toxicity to the hepatic or erythropoietic marrow tissues.
Porphyrins
A group of compounds containing the porphin structure, four pyrrole rings connected by methine bridges in a cyclic configuration to which a variety of side chains are attached. The nature of the side chain is indicated by a prefix, as uroporphyrin, hematoporphyrin, etc. The porphyrins, in combination with iron, form the heme component in biologically significant compounds such as hemoglobin and myoglobin.
Porphyrinogens
Colorless reduced precursors of porphyrins in which the pyrrole rings are linked by methylene (-CH2-) bridges.
Physician-Patient Relations
The interactions between physician and patient.
Injections, Intravenous
Injections made into a vein for therapeutic or experimental purposes.
Phytotherapy
Use of plants or herbs to treat diseases or to alleviate pain.
Drugs, Chinese Herbal
Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China.
Universal Precautions
Prudent standard preventive measures to be taken by professional and other health personnel in contact with persons afflicted with a communicable disease, to avoid contracting the disease by contagion or infection. Precautions are especially applicable in the diagnosis and care of AIDS patients.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export. (1/40)

The multidrug resistance proteins MRP1 and MRP2 are members of the same subfamily of ATP-binding cassette transporters. Besides organic molecules conjugated to negatively charged ligands, these proteins also transport cytotoxic drugs for which no negatively charged conjugates are known to exist. In polarized MDCKII cells, MRP1 routes to the lateral plasma membrane, and MRP2 to the apical plasma membrane. In these cells MRP1 transports daunorubicin, and MRP2 vinblastine; both transporters export reduced glutathione (GSH) into the medium. We demonstrate that glutathione transport in MDCKII-MRP1 cells is inhibited by the inhibitors of organic anion transporters sulfinpyrazone, indomethacin, probenecid and benzbromarone. In MDCKII-MRP2 cells, GSH export is stimulated by low concentrations of sulfinpyrazone or indomethacin, whereas export is inhibited down to control levels at high concentrations. We find that unmodified sulfinpyrazone is a substrate for MRP2, also at concentrations where GSH export is inhibited. We also show that GSH export in MDCKII-MRP2 cells increases in the presence of vinblastine, and that the stoichiometry between drug and GSH exported is between two and three. Our data indicate that transport of sulfinpyrazone and vinblastine is associated with GSH export. However, at high sulfinpyrazone concentrations this compound is transported without GSH. Models of MRP action are discussed that could explain these results.  (+info)

Effect of urate-lowering therapy on the velocity of size reduction of tophi in chronic gout. (2/40)

OBJECTIVE: The optimal serum urate levels necessary for elimination of tissue deposits of monosodium urate in patients with chronic gout is controversial. This observational, prospective study evaluates the relationship between serum urate levels during therapy and the velocity of reduction of tophi in patients with chronic tophaceous gout. METHOD: Sixty-three patients with crystal-confirmed tophaceous gout were treated with allopurinol, benzbromarone, or combined therapy to achieve serum uric acid levels less than the threshold for saturation of urate in tissues. The tophi targeted for evaluation during followup were the largest in diameter found during physical examination. RESULTS: Patients taking benzbromarone alone or combined allopurinol and benzbromarone therapy achieved faster velocity of reduction of tophi than patients taking allopurinol alone. The velocity of tophi reduction was linearly related to the mean serum urate level during therapy. The lower the serum urate levels, the faster the velocity of tophi reduction. CONCLUSION: Serum urate levels should be lowered enough to promote dissolution of urate deposits in patients with tophaceous gout. Allopurinol and benzbromarone are equally effective when optimal serum urate levels are achieved during therapy. Combined therapy may be useful in patients who do not show enough reduction in serum urate levels with single-drug therapy.  (+info)

Effects of aspirin and/or salicylate on hydrolysis and glucuronidation of indomethacin in rat erythrocytes and hepatocytes. (3/40)

This study was conducted to explore the mechanism of the pharmacokinetic interaction between aspirin (ASP) and indomethacin (IND) using rat erythrocytes (RBCs) and hepatocytes. ASP was hydrolyzed to salicylic acid (SA) in both the RBCs and hepatocytes. Within RBCs, aspirin and/or salicylate (ASP/SA) increased the concentration of IND, accompanied by a constant hydrolysis of IND. In hepatocytes, a low dose of IND was subjected to glucuronidation rather than hydrolysis, and ASP/SA inhibited both the acylglucuronidation of IND and hydrolysis of IND glucuronide. A high dose of IND underwent hydrolysis with about double the glucuronidation, and ASP/SA decreased the ratio of hydrolysis to glucuronidation, accompanied by a loss of ASP, IND and their metabolites from the medium. Collectively, the results provide metabolic insight into the mechanism of drug-drug interaction between ASP/SA and IND in the hepatocytes and RBCs.  (+info)

A new class of CYP2C9 inhibitors: probing 2C9 specificity with high-affinity benzbromarone derivatives. (4/40)

Noncovalent forces, other than hydrophobic interactions, are important determinants of substrate bias exhibited by some cytochromes P450. The CYP2C9 pharmacophore is proposed to include either an anionic group or hydrogen bond donor in addition to its hydrophobic groups. By constructing analogs of benzbromarone, evidence supporting the existence of a 2C9 anion-binding site was revealed. A nonsubstituted phenol analog was determined to have a pKa of 8.4 and a Ki of 414 nM whereas those with dihalogenated benzoyl phenols had pKa values between 4.2 to 5.2 and Ki values as low as 1 nM. The nonhalogenated, nonionizable analog is the poorest binder at 796 nM. The Ki range covers around three orders of magnitude with even the weakest binder being a more potent inhibitor than 2C9 substrate phenytoin. Thus, benzbromarone derivatives represent a class of molecules with the potential to reveal more structural details of the 2C9 active site.  (+info)

A case of exercise-induced acute renal failure in a patient with idiopathic renal hypouricemia developed during antihypertensive therapy with losartan and trichlormethiazide. (5/40)

Exercise-induced acute renal failure (ARF) developed in a 45-year-old man during antihypertensive therapy with losartan and trichlormethiazide. The antihypertensive therapy was stopped and marked hypouricemia became apparent during improvement of his renal function. The daily urinary excretion of uric acid was normal and an increased fractional excretion of uric acid was observed. Renal biopsy revealed that the kidney was recovering from acute tubular necrosis with interstitial fibrosis. Based on the results of pyrazinamide and benzbromarone tests, we classified this case as one of presecretory reabsorption defect of uric acid. Antihypertesive therapy with benidipine and candesartan was initiated, and the patient has not had any ARF episodes since. Because idiopathic renal hypouricemia can be associated with exercise-induced ARF and chronic renal dysfunction, careful antihypertensive therapy and follow-up evaluation of renal function might be necessary for hypertensive patients with idiopathic renal hypouricemia.  (+info)

Circadian rhythm of plasma uric acid and handling stress-induced hyperuricemia in conscious cebus monkeys. (6/40)

An apparent circadian rhythm of plasma uric acid and the effect of handling stress on plasma uric acid level in conscious cebus monkeys were demonstrated. The lowest level of plasma uric acid in the circadian rhythm occurred early in the morning and the highest, before bedtime at night. With experimental handling stress, the plasma uric acid level rose to much more than the maximum level of the circadian rhythm. Stress-induced hyperuricemia could be inhibited without an increase of urinary uric acid excretion by the minor tranquilizer diazepam at doses of more than 1 mg/kg, p.o. On the other hand, benzbromarone at 20 mg/kg, p.o. significantly inhibited the hyperuricemia with a hyperuricosuric effect, while probenecid at 50 mg/kg, p.o. had no effect on either the increased plasma uric acid or urinary uric acid excretion. Accordingly, it is concluded that the plasma uric acid level in conscious cebus monkeys easily fluctuates with experimental conditions and that the animals can be utilized to evaluate the hypouricemic and hyperuricosuric property of benzbromarone-like agents.  (+info)

CYP2C9 genotype-dependent effects on in vitro drug-drug interactions: switching of benzbromarone effect from inhibition to activation in the CYP2C9.3 variant. (7/40)

The CYP2C9.3 variant exhibits marked decreases in substrate turnover compared with the wild-type enzyme, but little is known regarding the effect this variant form may have on the occurrence of drug-drug interactions. To examine this possibility, the effect of the potent CYP2C9 inhibitor, benzbromarone, was studied with regard to CYP2C9.1- and CYP2C9.3-mediated flurbiprofen metabolism to evaluate whether the variant enzyme exhibits differential inhibition kinetics. Although benzbromarone inhibited CYP2C9.1 activity as expected, CYP2C9.3-mediated flurbiprofen 4'-hydroxylation was activated in the presence of benzbromarone. T1 relaxation studies revealed little change in distances of flurbiprofen protons from the heme iron of either CYP2C9.1 or CYP2C9.3 in the presence of benzbromarone compared with flurbiprofen alone. Spectral binding studies were also performed to investigate whether benzbromarone affected substrate binding, with the addition of benzbromarone having little effect on flurbiprofen-binding affinity in both CYP2C9.1 and CYP2C9.3. Docking studies with the 2C9.1 structure crystallized with a closed active site identified multiple but overlapping subsites with sufficient space for benzbromarone binding in the enzyme when flurbiprofen was positioned closest to the heme. If the closed conformation of 2C9.3 is structurally similar to 2C9.1, as expected for the conservative I359L mutation, then the dynamics of benzbromarone binding may account for the switching of drug interaction effects. In conclusion, the I359L amino acid substitution found in CYP2C9.3 not only reduces metabolism compared with CYP2C9.1 but can also dramatically alter inhibitor effects, suggesting that differential degrees of drug inhibition interactions may occur in individuals with this variant form of CYP2C9.  (+info)

Prediction of CYP2C9-mediated drug-drug interactions: a comparison using data from recombinant enzymes and human hepatocytes. (8/40)

The IC50 values of 14 drugs were determined in recombinantly expressed CYP2C9 (rCYP2C9) and human hepatocytes and the data used to simulate clinical area under the plasma concentration-time curve (AUC) changes upon coadministration with prototypic CYP2C9 substrates. There was an excellent correlation between IC(50, apparent) values determined using diclofenac and naproxen as CYP2C9 substrates (r2 = 0.82, p < 0.0001), with values being generally higher in the naproxen assay. After correcting for nonspecific binding, the IC(50, unbound) values were similar between the assays, for the majority of compounds. Two compounds, amiodarone and benzbromarone, demonstrated substrate-specific differences, activating naproxen O-demethylase to approximately 250% of control activity at 1 mM and 1 microM, respectively, while inhibiting diclofenac 4'-hydroxylation with IC(50, apparent) values of 3 microM and 0.04 microM, respectively. CYP2C9 IC(50, apparent) values generated in human hepatocytes were systematically higher than those determined with rCYP2C9. After correcting for nonspecific binding, there was an excellent correlation of IC(50, unbound) values generated in the different milieu (r2 = 0.88, p < 0.0001). The ratio of inhibitor concentration at the entrance to the liver to the inhibition constant ([I]in/Ki) was used to simulate clinical deltaAUC changes and compared with that observed in vivo. Where [I]in, total/Ki, apparent) was used, there were zero false negatives (observed deltaAUC >or=2, predicted deltaAUC <2), eight correct assignations, and seven false positives (observed deltaAUC 2. Where [I]in, unbound/Ki, unbound was used, there was one false negative, 14 correct assignations, and zero false positives. In summary, the data presented here suggest that for CYP2C9 interactions, the use of total liver inhibitor concentrations may indeed avoid false negatives, but more realistic predictions may be achieved using unbound liver inhibitor concentrations and unbound in vitro inhibition parameters.  (+info)

Benzbromarone | CAS#3562-84-3 | MedKooBenzbromarone | CAS#3562-84-3 | MedKoo
Benzbromarone is a uricosuric agent and non-competitive inhibitor of xanthine oxidase used in the treatment of gout, especially when allopurinol, a first-line treatment, fails or produces intolerable adverse effects. It is structurally related to the antiarrhythmic amiodarone. Benzbromarone is highly effective and well tolerated, and clinical trials as early as 1981 and as recently as April 2008 have suggested it is superior to both allopurinol, a xanthine oxidase inhibitor but not uricosuric, and probenecid, another uricosuric drug.
https://www.medkoo.com/products/10738
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Sequential metabolism and bioactivation of the hepatotoxin benzbromarone: formation of glutathione adducts from a catechol...Sequential metabolism and bioactivation of the hepatotoxin benzbromarone: formation of glutathione adducts from a catechol...
Benzbromarone (BBR) is a uricosuric agent that has been used as a treatment for chronic gout. Although never approved in the United States, BBR was recently withdrawn from European markets due to several clinical cases linking the drug to an idiosyncratic hepatotoxicity that is sometimes fatal. We r …
https://pubmed.ncbi.nlm.nih.gov/18020424/?dopt=Abstract
Efficacy of allopurinol and benzbromarone for the control of hyperuricaemia. A pathogenic approach to the treatment of primary...Efficacy of allopurinol and benzbromarone for the control of hyperuricaemia. A pathogenic approach to the treatment of primary...
This study shows that benzbromarone is very useful for the control of hyperuricaemia using doses ranging from 50 to 100 mg/day. It also shows that 47% of our patients taking allopurinol did not achieve optimal Pur concentrations with 300 mg/day despite alcohol abstinence and weight reduction. Previous studies showed that poor control of uricaemia is common,23-27 and it may result in radiological progression of bony lesions,23 increased size of tophi,23 and frequent recurrence of gouty bouts and tophi after withdrawal of urate lowering treatment.24 25 27 Although most standard sources of information recommend uricosurics to correct hyperuricaemia in underexcretors,5-8 29 30this approach is not a common practice in more recent studies.23-26 Epidemiological studies show that only 2-15% of patients with gout were taking uricosuric drugs.30-32 It may be because uricosurics such as probenecid or sulphinpyrazone have to be given in a twice daily regimen and have little efficacy in patients with low ...
https://ard.bmj.com/content/57/9/545
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Plus itPlus it
In the present study we identified a novel compound, UR-1102, as a potent URAT1 inhibitor that is selective over OAT1 and OAT3. In the monkey model, UR-1102 showed a better PK profile and reduced the levels of urate in plasma to a greater extent through its stronger uricosuric effect compared with benzbromarone, even when the plasma exposures were comparable, and achieved a maximum efficacy twice that of benzbromarone at a lower dose. Additionally, UR-1102 showed lower in vitro toxic potential in every mechanism that has been proposed for the hepatic toxicity of benzbromarone.. OAT1 and OAT3 are nonspecific anion transporters reported to be involved in urate excretion. Because they are both expressed in the basolateral membrane of renal proximal tubules and transport urate from the blood to inside the cells (Bakhiya et al., 2003; Ichida et al., 2003; Choi et al., 2005), inhibiting these transporters would decrease the secretion of urate into the urine. As mentioned earlier, the inability of ...
http://jpet.aspetjournals.org/content/357/1/157
Benzbromarone - dot1linhibitor.comBenzbromarone - dot1linhibitor.com
Ramark: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ℃ for several month.PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/27500836?dopt=Abstract. ...
https://www.dot1linhibitor.com/2017/06/29/Benzbromarone/
Global Scaffold Free 3D Cell Culture Plate Market Research Report 2017, Trends, Share, Size Research ReportGlobal Scaffold Free 3D Cell Culture Plate Market Research Report 2017, Trends, Share, Size Research Report
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Results. In total, 3206 references were recovered. Of these, 72 articles were selected based on our inclusion criteria. This included 1 report of 2 randomized controlled trials, 2 nonrandomized studies, and 69 case series and reports. The study with 2 randomized controlled trials looked at pegloticase. This showed improvement in tophi with treatment. One observational prospective trial looked at allopurinol and benzbromarone individually and in combination. It noted that achieving lower serum urate levels was associated with a faster reduction of tophi. An open-label extension trial noted that longterm maintenance of serum uric acid , 6.0 mg/dl with febuxostat led to a reduction in tophi. The case series and reports looked at surgical, pharmacological, and other interventions, as well as combination therapies. All surgical interventions reported improvement in pain and/or function. No report had objective measures of outcome. ...
http://www.jrheum.org/content/92/63
Uric Acid-Lowering Therapy May Improve Renal Outcomes in CKD Patients - MPRUric Acid-Lowering Therapy May Improve Renal Outcomes in CKD Patients - MPR
A study published in PLOS One found that uric acid-lowering therapy improved renal outcomes and lowered the risk of cardiovascular (CV) events in adult pat
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Biometic - Bioactive Tissue Scaffold SystemsBiometic - Bioactive Tissue Scaffold Systems
The iaxsys™ is a unique in vitro mechanobiology actuator that is compatible with established cell culture methods, consumables and incubators.. This versatile bioreactor platform facilitates near-physiologic strain of 2D membranes and scaffolds, thick 3D scaffolds (variotis™), ex vivo tissues, and soft tissue implants (eg bovine pericardium xenograft heart valve materials) within standard cell culture plates and flasks.. Quasi-static strain or cyclic strain can be applied uniformly to 6 samples simultaneously within a 6 well cell plate with a specified rate and number of cycles. Depending on the configuration, tensile or compression stresses are imparted.. When the iaxsys™ is used to actuate variotis™ scaffolds for mechanobiology studies in standard 6 well cell culture plates, the quality of RNA sampled is of a very high level. Unlike biologically derived gels and scaffolds, the fully synthetic variotis™ with b-glass™ avoids any contamination. The use of standard cell well plates ...
https://www.biometic.com.au/
Griffin: Ultimate Immunoprecipitation Guide - OpenWetWareGriffin: Ultimate Immunoprecipitation Guide - OpenWetWare
Below is a procedure for adherent cells (ie A431, A549, Hela, NIH3T3) I) Remove culture medium and rinse a subconfluent, 100 mm cell culture plate (80% confluent plate yields ~600-1000 microg protein total) with PBS at room temperature. The following steps should be performed on ice or at 4° C using fresh, ice cold buffers. II) Add 0.8 ml of ice cold fresh RIPA buffer to the 100 mm cell culture plates OR 0.5 ml per 5 x 10e6 cells/60 mm dish. III) Gently rock plates for 15 minutes at 4° C or let the plates set on ice. This step will allow the lysis buffer to act on the cells and will increase the total yield of soluble protein. IV) For monolayer cells, do a trypsin treatment to lift cells off the flasks prior to cell lysis, instead of scraping the cells for a more gentle approach. OR Scrape the adherent cells with a cell scraper and then transfer the scraped lysate into a sterile microcentrifuge tube. Place the tube on ice. Optional: wash the plate once with 0.2 ml of RIPA buffer and combine ...
https://openwetware.org/wiki/?title=Griffin:_Ultimate_Immunoprecipitation_Guide&oldid=245922
Argos Technologies® Cell and Tissue Culture Plates from Cole-ParmerArgos Technologies® Cell and Tissue Culture Plates from Cole-Parmer
Buy Argos Technologies® Cell and Tissue Culture Plates and more from our comprehensive selection of Cell Culture Plates from Cole-Parmer
https://www.coleparmer.com/p/argos-technologies-cell-and-tissue-culture-plates/61527
FACTORS THAT AFFECT CELL CULTURE - Microbiology ClassFACTORS THAT AFFECT CELL CULTURE - Microbiology Class
Cell or tissue culture experimentations should not be carried out in the regular laboratory space where other laboratory investigations are undertaken. This is critical to avoid contamination of cells in the cell culture plates and also to ensure that all the physiochemical environmental factors that encourage optimal growth of the cells are provided. Thus, cell culture experimentations should be carried out in a specialized laboratory or an area in the regular laboratory that is secluded from the usual laboratory area in order to achieve optimal result. Some key environmental conditions (i.e. the physiochemical or physico-chemical environmental growth factors) must be met in order to achieve optimum cell/tissue culture technique.. The microenvironment in which cell culture technique is basically carried out is unique and quite different from the traditional microbial cultures that also occur in vitro in the sense that tissue culture support the growth of living cells or cultures derived from ...
https://microbiologyclass.com/factors-that-affect-cell-culture/
Cell Culture Consumables - EppendorfCell Culture Consumables - Eppendorf
Do you use all wells of your 96 well plate including the outer ones? Usually, these wells are not used for a good reason: Increased evaporation in the outer wells reduces reproducibility and comparability between all wells (edge effect). Therefore, more than a third of a plate is not used. More experiments are necessary which mean higher costs. With Eppendorf Cell Culture Plates, the surrounding moat can be filled. This significantly reduces the edge effect and all wells become comparable. Learn more by reading our Application Notes 326 and 384. ...
https://www.eppendorf.com/KR-ko/ccc/
96 Well Plates V Bottom at Thomas Scientific96 Well Plates V Bottom at Thomas Scientific
96 Well Plates V Bottom found in: 96-Well Deep Round and Square Plates, 96 Well Polystyrene Microplates, CapMats, Denville® Untreated Cell Culture Plates,..
https://www.thomassci.com/scientific-supplies/96-Well-Plates-V-Bottom
CELL DEATH IN PLATESCELL DEATH IN PLATES
It really does sound like a bad batch of plates. Perhaps you could post the lot number and people with the same lot could compare notes? Peter French wrote: , , angelpet wrote: , ,Rusnak is EXACTLY right. Its an evaporation problem. I use a lot of , ,96-well plates and no longer use any of the outer wells . . . I fill them , ,with sterile water. So, I only get 60 wells, but I grow things long-term , ,so . . . .. , , , ,Dont be fooled by the name . . . Im not a bimbo, but I play one on the , ,net! , , , EXACTLY WRONG! , Sloppy thinking. Can we all get back to the original question (I reproduce , it here): , Thomas Kreuzer wrote: , , , , Hello fellow netters, , , , , I have been faced with a problem recently , for which I can find no solution , , altough it may be trivial. , , I seed HeLa - cells on standard 6-well cell culture plates (Costar) in 1 ml , , DMEM plus 5 % FCS , let them attach to the bottom overnight and then change , , the medium according to the tests I want to perform ...
http://www.bio.net/bionet/mm/cellbiol/1996-November/005721.html
Culture PS, 6 85.4x127.6mm, Flat Bottom, TC treated, Sterile | Technique alternative | 01013807912 - Gentaur.DECulture PS, 6 85.4x127.6mm, Flat Bottom, TC treated, Sterile | Technique alternative | 01013807912 - Gentaur.DE
Order Cell Culture Plate PS 6 well 85 4x127 6mm Flat Bottom TC treated Sterile 01013807912 at Gentaur Culture PS, 6 85.4x127.6mm, Flat Bottom, TC treated,
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Microorganisms in stable air as possible postsecretory milk contaminantsMicroorganisms in stable air as possible postsecretory milk contaminants
Quality and hygienic correct milk must satisfy conditions which are prescribed by Law on Raw Milk Quality (NN102/2000). If we know that freshly milked milk could contain a certain number of microorganisms originating from the stable air...
https://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=12761
Osteoporosis | Hybrid Medical AnimationOsteoporosis | Hybrid Medical Animation
Here in the micro-space of cancellous bone, we can see microarchitectural deterioration due to osteoclasts breaking down trabeculae. This destruction leads to bone fragility and vulnerability to fracture.
https://www.hybridmedicalanimation.com/work/illustration/osteoporosis/
Zhejiang Sorfa Life Science Research Co., Ltd. - Laboratory and Medical Consumables: Cell Culture Flask,Cell Culture PlateZhejiang Sorfa Life Science Research Co., Ltd. - Laboratory and Medical Consumables: Cell Culture Flask,Cell Culture Plate
Zhejiang Sorfa Life Science Research Co., Ltd., Experts in Manufacturing and Exporting Laboratory and Medical Consumables: Cell Culture Flask,Cell Culture Plate and 209 more Products. A Verified CN Gold Supplier on Alibaba.com.
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Lesinurad in combination with allopurinol: results of a phase 2, randomised, double-blind study in patients with gout with an...Lesinurad in combination with allopurinol: results of a phase 2, randomised, double-blind study in patients with gout with an...
The algorithm based on the ACR guidelines for escalation of urate-lowering therapy recommends that, in patients not achieving target sUA after upward titration of an initial XO inhibitor, another should be substituted.5 ,6 This may also be combined with a uricuretic agent that provides a therapeutic increase in UA excretion from the kidney.14 Further reduction to sUA ,5 mg/dL is recommended for severe gout, polyarticular gout and tophaceous gout.5 ,6 Patients refractory to or intolerant of such options are candidates for pegloticase.5 Pegloticase is associated with infusion-related reactions, including anaphylaxis, and requires pretreatment with antihistamines and corticosteroids.16 ,17 Probenecid may be ineffective in patients with chronic renal disease, has associated drug-drug interactions, and requires twice-daily or four-times-daily dosing.18 Benzbromarone has limited availability worldwide and is associated with safety issues. Thus, a safe, effective, and potent URAT1 inhibitor would ...
http://ard.bmj.com/content/early/2016/01/07/annrheumdis-2015-207919
Burmester Pharmatrade GmbHBurmester Pharmatrade GmbH
Burmester liefert: pharmazeutische Rohstoffe, Wirkstoffe, Wirksubstanzen, Allantoin, PAMBA, Antazoline, Antipyrine, Arabic Gum, Baclofen, Belladonna, Bendazac, Benzbromarone, Benzocaine, Betamethasone, Calcitonin, Calcium ...
http://burmester-pharma.de/spanisch/produkte/index.php?alphabet=Q
Burmester Pharmatrade GmbHBurmester Pharmatrade GmbH
Burmester liefert: pharmazeutische Rohstoffe, Wirkstoffe, Wirksubstanzen, Allantoin, PAMBA, Antazoline, Antipyrine, Arabic Gum, Baclofen, Belladonna, Bendazac, Benzbromarone, Benzocaine, Betamethasone, Calcitonin, Calcium ...
http://burmester-pharma.de/englisch/produkte/index.php?alphabet=K
Dalmatian dog - WikipediaDalmatian dog - Wikipedia
Hyperuricemia in Dalmatians (as in all breeds) is inherited, but unlike other breeds, the normal gene for a uric acid transporter that allows for uric acid to enter liver cells and be subsequently broken down is not present in the breeds gene pool. Therefore, there is no possibility of eliminating hyperuricemia among pure-bred Dalmatians. The only possible solution to this problem must then be crossing Dalmatians with other breeds to reintroduce the normal uric acid transporter gene. This led to the foundation of the Dalmatian-Pointer Backcross Project, which aims to reintroduce the normal uric acid transporter gene into the Dalmatian breed. The backcross used a single English Pointer; subsequent breedings have all been to purebred Dalmatians. This project was started in 1973 by Dr. Robert Schaible. The first cross (F1) hybrids did not resemble Dalmatians very closely. The F1s were then crossed back to purebreds. This breeding produced puppies of closer resemblance to the pure Dalmatian. By ...
https://en.m.wikipedia.org/wiki/Dalmatian_
BD | HUBERLAB. eShopBD | HUBERLAB. eShop
Cell culture flasks , roller bottles , multilayer cell culture vessels, cell culture plates , inserts , cell culture tubes , cell culture dishes , Poly-D-Lysine , incubators, cryotubes , slides , ELISA plates ...
http://www.huberlab.ch/Brands/BD/c/BD
Imprint | HUBERLAB. eShopImprint | HUBERLAB. eShop
Cell culture flasks , roller bottles , multilayer cell culture vessels, cell culture plates , inserts , cell culture tubes , cell culture dishes , Poly-D-Lysine , incubators, cryotubes , slides , ELISA plates ...
https://www.huberlab.ch/imprint
Cell Migration, Invasion and Wound Healing | Cell BiolabsCell Migration, Invasion and Wound Healing | Cell Biolabs
Cell migration is a highly integrated, multi-step process that plays an important role in the progression of various diseases including cancer, atherosclerosis and arthritis. There are various types and definitions of cell migration. Cell invasion is related to, and encompasses, cell migration, except that cells do more than migrate. Invasive cells move through the extracellular matrix into neighboring tissues in a process that involves ECM degradation and proteolysis. We offer cell migration assays in two formats: Boyden Chamber Assays consist of a cell culture insert nested in the well of cell culture plate. Cells are seeded into the insert and migrate through the pores of the membrane at the bottom of the insert. Gap Closure Assays create a defined area across which cells migrate. Cell migration can be monitored in real time by microscopy. These assays include our new proprietary Radius™ technology which uses a biocompatible hydrogel to create a circular area across which cells can
https://www.cellbiolabs.com/cell-migration-invasion-wound-healing
high gradient separatorshigh gradient separators
High field gradient targeting of magnetic nanoparticle PNAS. Jan 15, 2008 loaded with magnetic nanoparticles or the field gradient, but not both, making highgradient magnetic fields are produced by the magnetizable wires of a .. on a magnetic separator adapted for cell culture plates by using a magnetic the Alamar blue assay as described by the manufacturer (Biosource).. Get Price ...
https://labelnight.nl/Feb-19/14959.html
Patent US20020076443 - Multiple phase cross-linked compositions and uses thereof - Google PatentsPatent US20020076443 - Multiple phase cross-linked compositions and uses thereof - Google Patents
The present invention is directed to pharmaceutical compositions, and method for preparing pharmaceutical compositions, comprising a cross-linked matrix physically entrapping at least one therapeutic agent. The matrix may comprise one or more phases in addition to an aqueous phase, such as a solid and/or oil phase. The matrix of the invention has at least one controlled release in-vivo kinetic profile, and may have additional profiles for the same agent. The matrix may also comprise more than one therapeutic agent, and each additional therapeutic agent may have one or more controlled release in-vivo kinetic profile.
http://www.google.com.au/patents/US20020076443
Interventions for tophi in gout | CochraneInterventions for tophi in gout | Cochrane
Background: what are tophi and what interventions are used? Gout is caused by urate crystals forming either within or around joints. Inflammation can lead to pain, redness, warmth and swelling of the affected joints, making the area difficult to touch or move. Some of the reasons why people get gout include their genetic make-up, being overweight, ingesting certain medications (e.g. cyclosporine), impaired kidney function and lifestyle habits such as drinking excessive amounts of alcohol and sugar-sweetened drinks. Tophi are nodules that develop in people with poorly treated or uncontrolled chronic gout. Tophi can become infected, cause pain and lead to a decrease in function. Tophi can be treated with urate-lowering drugs (e.g. benzbromarone, probenecid, allopurinol, febuxostat, pegloticase), surgical removal or other interventions such as haemodialysis. Surgical interventions can be used where urgent removal is required, for example, for relief of nerve compression.. Study characteristics This ...
http://www.cochrane.org/CD010069/MUSKEL_interventions-for-tophi-in-gout
Loss of ATP-dependent transport activity in pseudoxanthoma elasticum-associated mutants of human ABCC6 (MRP6)<...Loss of ATP-dependent transport activity in pseudoxanthoma elasticum-associated mutants of human ABCC6 (MRP6)<...
TY - JOUR. T1 - Loss of ATP-dependent transport activity in pseudoxanthoma elasticum-associated mutants of human ABCC6 (MRP6). AU - Iliás, Attila. AU - Urbán, Zsolt. AU - Seidl, Thomas L.. AU - Saux, Olivier Le. AU - Sinkó, Emese. AU - Boyd, Charles D.. AU - Sarkadi, B.. AU - Váradi, A.. PY - 2002/5/10. Y1 - 2002/5/10. N2 - Mutations in the ABCC6 (MRP6) gene cause pseudoxanthoma elasticum (PXE), a rare heritable disorder resulting in the calcification of elastic fibers. In the present study a cDNA encoding a full-length normal variant of ABCC6 was amplified from a human kidney cDNA library, and the protein was expressed in Sf9 insect cells. In isolated membranes ATP binding as well as ATP-dependent active transport by ABCC6 was demonstrated. We found that glutathione conjugates, including leukotriene C4 and N-ethylmaleimide S-glutathione (NEM-GS), were actively transported by human ABCC6. Organic anions (probenecid, benzbromarone, indomethacin), known to interfere with glutathione conjugate ...
https://hungary.pure.elsevier.com/en/publications/loss-of-atp-dependent-transport-activity-in-pseudoxanthoma-elasti
Frontiers | Automation, Monitoring, and Standardization of Cell Product Manufacturing | Bioengineering and BiotechnologyFrontiers | Automation, Monitoring, and Standardization of Cell Product Manufacturing | Bioengineering and Biotechnology
Although regenerative medicine products are at the forefront of scientific research, technological innovation, and clinical translation, their reproducibility and large-scale production are compromised by automation, monitoring, and standardization issues. To overcome these limitations, new technologies at software (e.g., algorithms and artificial intelligence models, combined with imaging software and machine learning techniques) and hardware (e.g., automated liquid handling, automated cell expansion bioreactor systems, automated colony-forming unit counting and characterization units, and scalable cell culture plates) level are under intense investigation. Automation, monitoring and standardization should be considered at the early stages of the developmental cycle of cell products to deliver more robust and effective therapies and treatment plans to the bedside, reducing healthcare expenditure and improving services and patient care.
https://www.frontiersin.org/articles/10.3389/fbioe.2020.00811/full?&utm_source=Email_to_authors_&utm_medium=Email&utm_content=T1_11.5e1_author&utm_campaign=Email_publication&field=&journalName=Frontiers_in_Bioengineering_and_Biotechnology&id=534204
ChemIDplus - 2465-59-0 - HXNFUBHNUDHIGC-UHFFFAOYSA-N - Oxypurinol [USAN] - Similar structures search, synonyms, formulas,...ChemIDplus - 2465-59-0 - HXNFUBHNUDHIGC-UHFFFAOYSA-N - Oxypurinol [USAN] - Similar structures search, synonyms, formulas,...
2465-59-0 - HXNFUBHNUDHIGC-UHFFFAOYSA-N - Oxypurinol [USAN] - Similar structures search, synonyms, formulas, resource links, and other chemical information.
https://chem.nlm.nih.gov/chemidplus/rn/2465-59-0
CYP2C9 Genotype-dependent Warfarin Pharmacokinetics: Impact of CYP2C9 Genotype on R- and S-Warfarin and Their Oxidative...CYP2C9 Genotype-dependent Warfarin Pharmacokinetics: Impact of CYP2C9 Genotype on R- and S-Warfarin and Their Oxidative...
Certara. Certara is the leading drug development consultancy with solutions spanning the discovery, preclinical and clinical stages of drug development.. ...
https://www.certara.com/citations/cyp2c9-genotype-dependent-warfarin-pharmacokinetics-impact-of-cyp2c9-genotype-on-r-and-s-warfarin-and-their-oxidative-metabolites/
Frontiers | Hypouricemic Effects of Ganoderma applanatum in Hyperuricemia Mice through OAT1 and GLUT9 | PharmacologyFrontiers | Hypouricemic Effects of Ganoderma applanatum in Hyperuricemia Mice through OAT1 and GLUT9 | Pharmacology
Ganoderma applanatum (G. applanatum) dispels wind to eliminate dampness and exhibited nephron- and liver-protective effects as noted in Chinese herbal classic literature; it might also affect hyperuricemia. Therefore, we examined the hypouricemia effects and mechanisms underlying G. applanatum on chemical-induced hyperuricemia in mice. Ethanol (GAE) and water (GAW) extracts were prepared by extracting G. applanatum in ethanol (GAE), followed by bathing the remains in water to yield GAW. GAE and GAW were administered orally at different doses to hyperuricemia mice, while allopurinol and benzbromarone served as positive controls. Both GAE and GAW showed remarkable hypouricemia activities, rendering a substantial decline in the SUA (serum uric acid) level in hyperuricemia control (P
https://www.frontiersin.org/articles/10.3389/fphar.2017.00996/full
sizers is phentermine safe while trying to get pregnant massive bleedingsizers is phentermine safe while trying to get pregnant massive bleeding
ANTICONVULSANTS PSYCHOSEDATIVES BENTIROMIDE BENTOCID BENTONITE BENTYL BENTYLOL BENURESTAT BENURON BENURYL BENZ(A)ANTHRACENE BENZAFLAVIN BENZALAZINE BENZALDEHYDE BENZALIN BENZALKONIUM BROMIDE BENZALKONIUM CHLORIDE BENZAMIDE BENZAMIDE-RIBOSIDE BENZAMIDINE BENZAMIDOSALICYLATE CALCIUM BENZAMIL benzamine BENZANTHRIN-A BENZANTHRIN-B BENZANTHRONE BENZAPRINOXIDE BENZARONE BENZASAL BENZASTATIN-A BENZASTATIN-B BENZASTATIN-C BENZASTATIN-D BENZATHINE BENZATHINE-BENZYLPENICILLIN BENZATHINE-CEFAPIRIN BENZATHINE-CHLORTETRACYCLINE BENZATHINE-CLOXACILLIN TRANQUILIZERS Page 102 п98 SECTION B BENZATHINE- PHENOXYMETHYLPENICILLIN BENZATROPINE BENZBROMARONE BENZEDREX BENZEDRINE BENZELMIN BENZENE BENZENEARSONATE BENZENESULFOHYDROXAMATE benzenesulfonylphenytoin-1 BENZESTROL BENZETHIDINE BENZETHONIUM CHLORIDE BENZETIMIDE benzhexol BENZHYDRAZONE BENZIDINE BENZIL BENZILATE BENZILONIUM BROMIDE BENZILYLCHOLINE BENZIMIDAZOLE BENZIMIDAZOLYL-UREA-2 BENZINDOPYRINE BENZIODARONE BENZMALECENE BENZMETANIDE BENZNIDAZOLE BENZO(A)PYRENE
http://design-citi.ru/discount-tabs-online-no-prescription/is-phentermine-safe-while-trying-to-get-pregnant.html
Plus itPlus it
The angiotensin II (AII) antagonist, losartan, increases uric acid excretion when administered to humans. However, the active metabolite of losartan, EXP 3174, and other nonpeptide AII antagonists such as eprosartan and SB 203220 are devoid of uricosuric activity. To investigate the mechanism of losartan-induced uricosuria, we examined the effects of losartan, EXP 3174, eprosartan and SB 203220 on OH- -dependent [14C]urate uptake into rat proximal tubule brush-border membrane vesicles. Losartan (10 microM) inhibited [14C]urate uptake at all time points examined, except at equilibrium (2 hr). Losartan had no effect on urate uptake in the absence of an OH- gradient. The inhibitory effect of losartan on urate uptake was concentration dependent (IC50 = 9.5 +/- 1.4 microM) and competitive in nature. The other AII antagonists also inhibited urate uptake but were 6-8-fold less potent than losartan with IC50 values of EXP 3174 (65 +/- 13 microM), eprosartan (60 +/- 7.0 microM) and SB 203220 (74 +/- 12.5 ...
http://jpet.aspetjournals.org/content/276/1/125
Safety of Urate Elevation in Parkinson's Disease - Full Text View - ClinicalTrials.govSafety of Urate Elevation in Parkinson's Disease - Full Text View - ClinicalTrials.gov
Background & Rationale:. Convergent epidemiological and clinical observations have identified urate - a major antioxidant and the end product of purine metabolism in humans - as the first molecular predictor of both the risk and the progression of typical Parkinsons disease (PD). Among some 1600 early PD patients enrolled in prior clinical trials, those with baseline serum urate levels in the highest quintile (i.e., in the upper normal range) displayed a 40% slower rate of clinical (disability) progression compared to those with baseline urate at or below the median (with p,0.000001 for trend across quintiles). Similarly, amongst those who underwent serial SPECT brain scans for changes in dopamine transporter (DAT) binding, those with higher baseline serum urate levels displayed a slower rate of radiographic progression (loss of striatal DAT). Moreover, urate levels in baseline cerebrospinal fluid (CSF) samples also correlate inversely with rates of clinical progression. Although this link ...
https://clinicaltrials.gov/ct2/show/NCT00833690
Special Instrument - Genecraft LabsSpecial Instrument - Genecraft Labs
The system consists of a mini-microscope, the CytoSMART™ Device (roughly the size of a cell culture plate), and an accompanying tablet which is linked to the device and can be fixed outside the incubator. With the CytoSMART™ Connect Cloud Service you can view your images and create time-lapse movies of your cell culture. As a cloud-based system, it enables you to access and download your cell culture data from any browser-capable system, whether it is your computer, laptop, smartphone or your personal tablet device. With the CytoSMART™ System your cells can remain in their defined conditions in the incubator, while you monitor the culture remotely online. Moreover, you can set automatic alerts - meaning you only need to physically tend to your cells once they have reached a certain confluency.. Applications for the CytoSMART™ System. With the CytoSMART™ System, both cell culture monitoring and the morphological read-out of a multitude of cell-based assays become routine tasks that can ...
http://genecraftlabs.com/category/instrument/special-instrument/
Influenza Medication: Antivirals, Influenza, Vaccines, Inactivated, Viral, Vaccines, Live, Viral, Uricosuric AgentsInfluenza Medication: Antivirals, Influenza, Vaccines, Inactivated, Viral, Vaccines, Live, Viral, Uricosuric Agents
Influenza, one of the most common infectious diseases, is a highly contagious airborne disease that occurs in seasonal epidemics and manifests as an acute febrile illness with variable degrees of systemic symptoms, ranging from mild fatigue to respiratory failure and death. Influenza causes significant loss of workdays, human suffering, and m...
https://emedicine.medscape.com/article/219557-medication
Adherence with urate-lowering therapies for the treatment of gout | Springer for Research & DevelopmentAdherence with urate-lowering therapies for the treatment of gout | Springer for Research & Development
Introduction Adherence to urate-lowering drugs (ULDs) has not been well evaluated among those with gout. Our aim was to assess the level and determinants of non-adherence with ULDs prescribed for gout.
https://rd.springer.com/article/10.1186/ar2659
Epidemiology and management of gout in Taiwan: a nationwide population study - Nottingham ePrintsEpidemiology and management of gout in Taiwan: a nationwide population study - Nottingham ePrints
RESULTS: Of 23,371,362 beneficiaries in 2010, there were 1,458,569 prevalent and 56,595 incident cases of gout, giving a prevalence of 6.24% (95% confidence interval (CI), 6.23% to 6.25%) and an incidence of 2.74 (95% CI, 2.72 to 2.76) per 1,000 person-years. The annual percentage change (APC) of the standardised prevalence was −0.7% (95% CI, −1.7% to 0.3%; P = 0.14), suggesting that the prevalence of gout was essentially the same throughout the study period. However, The APC of incidence was −13.4 (95% CI, −16.1 to −10.6) between 2005 and 2007 and −2.1 (95% CI, −10.4 to 7.1) between 2007 and 2010. Regions with the highest prevalence and incidence were eastern coastal counties and offshore islets, where indigenous people are clustered. Among prevalent gout cases in 2010, only 22.93% (95% CI, 22.87% to 23.00%) were prescribed urate-lowering treatment (ULT), which remained unchanged between 2005 and 2010 at an APC of 0.0 (95% CI, −3.8 to 4.0). Uricosuric agents were more commonly ...
http://eprints.nottingham.ac.uk/35896/
Sulfinpyrazone | CAS 57-96-5 | LGC StandardsSulfinpyrazone | CAS 57-96-5 | LGC Standards
Buy Sulfinpyrazone, CAS number: 57-96-5, online for pharmaceutical analytical testing. The highest quality reference standards for reliable results.
https://us.lgcstandards.com/US/en/Sulfinpyrazone/p/EPS2159000
Probenecid and ColchicineProbenecid and Colchicine
DESCRIPTION Probenecid and Colchicine contains probenecid, which is a uricosuric agent, and colchicine, which has antigout activity, the mechanism of which is unknown. Probenecid is the generic name for 4-[(dipropylamino)sulfonyl] benzoic ac...
http://www.egeneralmedical.com/rxlist00000389.html
Urate levels increased (urine) - RightDiagnosis.comUrate levels increased (urine) - RightDiagnosis.com
Urate levels increased (urine) information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues.
http://www.rightdiagnosis.com/medical/urate_levels_increased_urine_.htm
Genotype-dependent sensitivity and tolerance to morphine and heroin. D by A Oliverio and C CastellanoGenotype-dependent sensitivity and tolerance to morphine and heroin. D by A Oliverio and C Castellano
Oliverio, A and Castellano, C, Genotype-dependent sensitivity and tolerance to morphine and heroin. Dissociation between opiate-induced running and analgesia in the mouse. (1974). Subject Strain Bibliography 1974. 795 ...
https://mouseion.jax.org/ssbb1974/795/
Genotype-dependent sensitivity to morphine. Dopamine involvement in m by M Trabucchi, P F. Spano et al.Genotype-dependent sensitivity to morphine. Dopamine involvement in m by M Trabucchi, P F. Spano et al.
Trabucchi, M; Spano, P F.; Racagni, G; and Oliverio, A, Genotype-dependent sensitivity to morphine. Dopamine involvement in morphine-induced running in the mouse. (1976). Subject Strain Bibliography 1976. 3228 ...
https://mouseion.jax.org/ssbb1976/3228/
In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model | Drug Metabolism &...In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model | Drug Metabolism &...
Although the above phenomena are commonly seen in kinetic profiles, they are not always appreciated by the investigators, and several examples exist of standard Michaelis-Menten hyperbolic curves forced through the data rather than the adoption of more suitable models. In other cases the paucity of data points precludes any meaningful selection of an alternative model. What will the consequences be of ignoring the nonhyperbolic nature of a kinetic profile and fitting the Michaelis-Menten equation? The extent of error and the consequences when scaled for in vivo prediction can be considered for three situations:. 1. For substrate inhibition, the consequences are clear in Fig. 1B. Substantial underestimation of Vmax will occur by merely ignoring the high concentration data points and forcing a standard Michaelis-Menten model through the remaining lower substrate concentration data. Also, Km would be poorly estimated. Thus there is a need for full description of the profile to allow for the impact ...
https://dmd.aspetjournals.org/content/28/3/246?ijkey=f2428b6ae47eae335bbf18708c739f076235cd5c&keytype2=tf_ipsecsha
Acetophenone, 4-hydroxyAcetophenone, 4-hydroxy
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
https://webbook.nist.gov/cgi/cbook.cgi?ID=C99934&Units=SI
What is Probenecid？ | PharmaceuticalWhat is Probenecid？ | Pharmaceutical
Probenecid is a uricosuric and branch blocking agent. It inhibits the re-absorption of uric acerbic in the kidneys, appropriately accretion the elimination of uric acerbic in urine and abbreviating urate levels in the blood. This stops new crystals forming, and helps old clear deposits to deliquesce . It is a lot of advantageous to under-excreters…
https://fluoridekfo.wordpress.com/2013/12/17/what-is-probenecid%EF%BC%9F/
DI-fusion Severe Hypouricemia Impairs Endothelium-Dependent...DI-fusion Severe Hypouricemia Impairs Endothelium-Dependent...
DI-fusion, le Dépôt institutionnel numérique de lULB, est loutil de référencementde la production scientifique de lULB.Linterface de recherche DI-fusion permet de consulter les publications des chercheurs de lULB et les thèses qui y ont été défendues.
https://difusion.ulb.ac.be/vufind/Record/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/296140/Details
CelivaroneCelivarone
Amiodarone Benzbromarone Benziodarone Budiodarone Dronedarone Gautier, P; Guillemare, E; Djandjighian, L; Marion, A; ...
https://en.wikipedia.org/wiki/Celivarone
UricosuricUricosuric
In some persons with loss-of-function mutations of URAT1, the uricosurics benzbromarone and losartan had no effect, suggesting ... The primary uricosuric drugs include probenecid, benzbromarone and sulfinpyrazone. Drugs with other primary uses, that have ...
https://en.wikipedia.org/wiki/Uricosuric
GoutGout
... benzbromarone, and colchicine. Long term medications are not recommended until a person has had two attacks of gout, unless ...
https://en.wikipedia.org/wiki/Gout
Xanthine oxidase inhibitorXanthine oxidase inhibitor
... benzbromarone". Drug Metabolism and Disposition. 33 (12): 1791-5. doi:10.1124/dmd.105.006056. PMID 16135657. Becker MA, ...
https://en.wikipedia.org/wiki/Xanthine_oxidase_inhibitor
BenziodaroneBenziodarone
Amiodarone Benzbromarone, the brominated analogue of benziodarone, used as an uricosuric Dronedarone Pizzichini M, Aleo MF, ...
https://en.wikipedia.org/wiki/Benziodarone
List of MeSH codes (D03)List of MeSH codes (D03)
... benzbromarone MeSH D03.438.127.125 - cantharidin MeSH D03.438.127.187 - citalopram MeSH D03.438.127.250 - fura-2 MeSH D03.438. ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D03)
ATC code M04ATC code M04
... combinations M04AB01 Probenecid M04AB02 Sulfinpyrazone M04AB03 Benzbromarone M04AB04 Isobromindione M04AB05 Lesinurad M04AC01 ...
https://en.wikipedia.org/wiki/ATC_code_M04
BudiodaroneBudiodarone
Amiodarone Benzbromarone Benziodarone Celivarone Dronedarone Roy D, Talajic M, Dorian P, Connolly S, Eisenberg MJ, Green M, Kus ...
https://en.wikipedia.org/wiki/Budiodarone
List of drugs: BeList of drugs: Be
Benzbromarone (INN) Benzedrex Benzestrol (INN) Benzethidine (INN) Benzethonium chloride (INN) Benzetimide (INN) Benzfetamine ( ...
https://en.wikipedia.org/wiki/List_of_drugs:_Be
BenzbromaroneBenzbromarone
... is highly effective and well tolerated, and clinical trials as early as 1981 and as recently as April 2008 have ... Benzbromarone is a very potent inhibitor of CYP2C9. Several analogues of the drug have been developed as CYP2C9 and CYP2C19 ... Benzbromarone was introduced in the 1970s and was viewed as having few associated serious adverse reactions. It was registered ... Benzbromarone is a uricosuric agent and non-competitive inhibitor of xanthine oxidase used in the treatment of gout, especially ...
https://en.wikipedia.org/wiki/Benzbromarone
Coomassie Brilliant BlueCoomassie Brilliant Blue
... R-250 was first used to visualise proteins in 1964 by Fazekas de St. Groth and colleagues. Protein samples were separated electrophoretically on a cellulose acetate sheet. The sheet was then soaked in sulfosalicylic acid to fix the protein bands and then transferred to a solution of the dye.[10] Two years later in 1965 Meyer and Lambert used Coomassie Brilliant Blue R-250 to stain protein samples after electrophoretic separation in a polyacrylamide gel. They soaked the gel in a dye solution containing methanol, acetic acid and water. As the dye stained the polyacrylamide gel as well as the protein, in order to visualise the protein bands they needed to destain the gel which they did electrophoretically.[11] Subsequent publications reported that polyacrylamide gels could be successfully destained using an acetic acid solution. The first report of the use of the "G" form of the dye to visualise protein bands in polyacrylamide gels came in 1967, where the dye was dissolved ...
https://en.wikipedia.org/wiki/Coomassie_Brilliant_Blue
IvermectinIvermectin
InChI=1S/C48H74O14.C47H72O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38;1-24(2)41-27(5)16-17-46(61-41)22-33-19-32(60-46)15-14-26(4)42(25(3)12-11-13-31-23-54-44-39(48)28(6)18-34(45(50)57-33)47(31,44)51)58-38-21-36(53-10)43(30(8)56-38)59-37-20-35(52-9)40(49)29(7)55-37/h12-15,19,25-26,28,30-31,33-45,49-50,52H,11,16-18,20-24H2,1-10H3;11-14,18,24-25,27,29-30,32-44,48-49,51H,15-17,19-23H2,1-10H3/b13-12+,27-15+,32-14+;12-11+,26-14+,31-13+/t25-,26-,28-,30-,31-,33+,34-,35-,36-,37-,38-,39-,40+,41-,42-,43+,44-,45+,47+,48+;25-,27-,29-,30-,32+,33-,34-,35-,36-,37-,38-,39+,40-,41+,42-,43-,44+,46+,47+/m00/s1 ...
https://en.wikipedia.org/wiki/Ivermectin
GuanosineGuanosine
... is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine can be phosphorylated to become guanosine monophosphate (GMP), cyclic guanosine monophosphate (cGMP), guanosine diphosphate (GDP), and guanosine triphosphate (GTP). These forms play important roles in various biochemical processes such as synthesis of nucleic acids and proteins, photosynthesis, muscle contraction, and intracellular signal transduction (cGMP). When guanine is attached by its N9 nitrogen to the C1 carbon of a deoxyribose ring it is known as deoxyguanosine. The antiviral drug acyclovir, often used in herpes treatment, and the anti-HIV drug abacavir, are structurally similar to guanosine. Guanosine is required for an RNA splicing reaction in mRNA, when a "self-splicing" intron removes itself from the mRNA message by cutting at both ends, re-ligating, and leaving just the exons on either side to be translated into protein.[1] ...
https://en.wikipedia.org/wiki/Guanosine
ParaxanthineParaxanthine
... is not produced by plants[citation needed] and is only observed in nature as a metabolite of caffeine in animals. Paraxanthine is also a natural metabolite of caffeine in some species of bacteria.[1] After intake, roughly 84% of caffeine is demethylated at the 3-position to yield paraxanthine, making it the chief metabolite of caffeine in the body.[2] Paraxanthine is also a major metabolite of caffeine in humans and other animals, such as mice.[3] Shortly after ingestion, caffeine is metabolized into paraxanthine by hepatic cytochrome P450,[4] which removes a methyl group from the N3 position of caffeine.[5] After formation, paraxanthine can be broken down to 7-methylxanthine by demethylation of the N1 position,[6] which is subsequently demethylated into xanthine or oxidized by CYP2A6 and CYP1A2 into 1,7-dimethylaric acid.[5] In another pathway, paraxanthine is broken down into 5-acetylamino-6-formylamino-3-methyluracil through N-acetyl-transferase 2, which is then broken down into ...
https://en.wikipedia.org/wiki/Paraxanthine
TheophyllineTheophylline
... has been shown to inhibit TGF-beta-mediated conversion of pulmonary fibroblasts into myofibroblasts in COPD and asthma via cAMP-PKA pathway and suppresses COL1 mRNA, which codes for the protein collagen.[24] It has been shown that theophylline may reverse the clinical observations of steroid insensitivity in patients with COPD and asthmatics who are active smokers (a condition resulting in oxidative stress) via a distinctly separate mechanism. Theophylline in vitro can restore the reduced HDAC (histone deacetylase) activity that is induced by oxidative stress (i.e., in smokers), returning steroid responsiveness toward normal.[25] Furthermore, theophylline has been shown to directly activate HDAC2.[25] (Corticosteroids switch off the inflammatory response by blocking the expression of inflammatory mediators through deacetylation of histones, an effect mediated via histone deacetylase-2 (HDAC2). Once deacetylated, DNA is repackaged so that the promoter regions of inflammatory genes ...
https://en.wikipedia.org/wiki/Theophylline
EnprofyllineEnprofylline
Lunell E, Svedmyr N, Andersson KE, Persson CG (1982). "Effects of enprofylline, a xanthine lacking adenosine receptor antagonism, in patients with chronic obstructive lung disease". European Journal of Clinical Pharmacology. 22 (5): 395-402. doi:10.1007/bf00542541. PMID 6288396 ...
https://en.wikipedia.org/wiki/Enprofylline
Adenosine diphosphateAdenosine diphosphate
ADP cycling supplies the energy needed to do work in a biological system, the thermodynamic process of transferring energy from one source to another. There are two types of energy: potential energy and kinetic energy. Potential energy can be thought of as stored energy, or usable energy that is available to do work. Kinetic energy is the energy of an object as a result of its motion. The significance of ATP is in its ability to store potential energy within the phosphate bonds. The energy stored between these bonds can then be transferred to do work. For example, the transfer of energy from ATP to the protein myosin causes a conformational change when connecting to actin during muscle contraction. It takes multiple reactions between myosin and actin to effectively produce one muscle contraction, and, therefore, the availability of large amounts of ATP is required to produce each muscle contraction. For this reason, biological processes have evolved to produce efficient ways to replenishment the ...
https://en.wikipedia.org/wiki/Adenosine_diphosphate
TheobromineTheobromine
Animals that metabolize theobromine (found in chocolate) more slowly, such as dogs,[26] can succumb to theobromine poisoning from as little as 50 grams (1.8 oz) of milk chocolate for a smaller dog and 400 grams (14 oz), or around nine 44-gram (1.55 oz) small milk chocolate bars, for an average-sized dog. The concentration of theobromine in dark chocolates (approximately 10 g/kg (0.16 oz/lb)) is up to 10 times that of milk chocolate (1 to 5 g/kg (0.016 to 0.080 oz/lb)) - meaning dark chocolate is far more toxic to dogs per unit weight or volume than milk chocolate. The same risk is reported for cats as well,[27] although cats are less likely to ingest sweet food, with most cats having no sweet taste receptors.[28] Complications include digestive issues, dehydration, excitability, and a slow heart rate. Later stages of theobromine poisoning include epileptic-like seizures and death. If caught early on, theobromine poisoning is treatable.[29] Although not common, the effects of theobromine ...
https://en.wikipedia.org/wiki/Theobromine
XanthineXanthine
Derivatives of xanthine (known collectively as xanthines) are a group of alkaloids commonly used for their effects as mild stimulants and as bronchodilators, notably in the treatment of asthma symptoms. In contrast to other, more potent stimulants like sympathomimetic amines, xanthines mainly act to oppose the actions of the sleepiness-inducing adenosine, and increase alertness in the central nervous system. They also stimulate the respiratory centre, and are used for treatment of infantile apnea. Due to widespread effects, the therapeutic range of xanthines is narrow, making them merely a second-line asthma treatment. The therapeutic level is 10-20 micrograms/mL blood; signs of toxicity include tremor, nausea, nervousness, and tachycardia/arrhythmia. Methylated xanthines (methylxanthines), which include caffeine, aminophylline, IBMX, paraxanthine, pentoxifylline,[9] theobromine, and theophylline, affect not only the airways but stimulate heart rate, force of contraction, and cardiac arrhythmias ...
https://en.wikipedia.org/wiki/Methylxanthines
3-Methylbutanoic acid3-Methylbutanoic acid
... , also known as β-methylbutyric acid or more commonly isovaleric acid, is an organic compound with the formula (CH3)2CHCH2CO2H. It is sometimes classified as a fatty acid. It is a colourless liquid that is sparingly soluble in water, but highly soluble in most common organic solvents. The compound occurs naturally, including in essential oils. Isovaleric acid has a strong pungent cheesy or sweaty smell, but its volatile esters have pleasing scents and are used widely in perfumery. It has been proposed that it is the anticonvulsant agent in valerian.[1] It is a major component of the cause of unpleasant foot odor, as it is produced by skin bacteria metabolizing leucine.[2] Isovaleric acid is seen as the primary cause of the flavors added to wine caused by Brettanomyces yeasts.[3] Other compounds produced by Brettanomyces yeasts include 4-ethylphenol, 4-vinylphenol, and 4-ethylguaiacol.[4] An excess of isovaleric acid in wine is generally seen as a defect,[4] as it can smell ...
https://en.wikipedia.org/wiki/3-Methylbutanoic_acid
Benzbromarone - WikipediaBenzbromarone - Wikipedia
Benzbromarone is highly effective and well tolerated, and clinical trials as early as 1981 and as recently as April 2008 have ... Benzbromarone is a very potent inhibitor of CYP2C9. Several analogues of the drug have been developed as CYP2C9 and CYP2C19 ... Benzbromarone was introduced in the 1970s and was viewed as having few associated serious adverse reactions. It was registered ... Benzbromarone is a uricosuric agent and non-competitive inhibitor of xanthine oxidase used in the treatment of gout, especially ...
https://en.wikipedia.org/wiki/Benzbromarone
Benzbromarone - DrugBankBenzbromarone - DrugBank
Benzbromarone has been used in trials studying the basic science and treatment of Heart Failure, Hyperuricemia, Chronic Kidney ... Benzbromarone. ATC Codes. M04AB03 - Benzbromarone*M04AB - Preparations increasing uric acid excretion. *M04A - ANTIGOUT ... Benzbromarone. Accession Number. DB12319. Type. Small Molecule. Groups. Investigational, Withdrawn. Description. Benzbromarone ... The metabolism of Albendazole can be decreased when combined with Benzbromarone.. Alosetron. The metabolism of Alosetron can be ...
https://www.drugbank.ca/drugs/DB12319
IJMS | Free Full-Text | Benzbromarone, Quercetin, and Folic Acid Inhibit Amylin AggregationIJMS | Free Full-Text | Benzbromarone, Quercetin, and Folic Acid Inhibit Amylin Aggregation
Interestingly, three of the compounds analyzed-benzbromarone, quercetin, and folic acid-are able to slow down amylin fiber ... Keywords: quercetin; benzbromarone; folic acid; amylin; amyloid; aggregation; type II diabetes quercetin; benzbromarone; folic ... Benzbromarone, Quercetin, and Folic Acid Inhibit Amylin Aggregation. Laura C. López 1,2. ... "Benzbromarone, Quercetin, and Folic Acid Inhibit Amylin Aggregation." Int. J. Mol. Sci. 17, no. 6: 964. ...
https://www.mdpi.com/1422-0067/17/6/964
Benzbromarone - toxicity, ecological toxicity and regulatory informationBenzbromarone - toxicity, ecological toxicity and regulatory information
Benzbromarone Illinois EPA list. Keith list. Colborn list. Benbrook list. Danish Inert list. EU list. Not Listed. Not Listed. ... Benzbromarone WHO Acute Hazard. TRI Acute Hazard. Material Safety Data Sheets. Acute rating from U.S. EPA product label. U.S. ... Benzbromarone CA Prop 65 Developmental Toxin. U.S. TRI Developmental Toxin. CA Prop 65 Female Reproductive Toxin. CA Prop 65 ... Benzbromarone IARC Carcinogens. U.S. NTP Carcinogens. California Prop 65 Known Carcinogens. U.S. EPA Carcinogens. TRI ...
http://www.pesticideinfo.org/Detail_Chemical.jsp?Rec_Id=PRI38534
Sequential metabolism and bioactivation of the hepatotoxin benzbromarone: formation of glutathione adducts from a catechol...Sequential metabolism and bioactivation of the hepatotoxin benzbromarone: formation of glutathione adducts from a catechol...
Benzbromarone (BBR) is a uricosuric agent that has been used as a treatment for chronic gout. Although never approved in the ... Benzbromarone (BBR) is a uricosuric agent that has been used as a treatment for chronic gout. Although never approved in the ... Sequential metabolism and bioactivation of the hepatotoxin benzbromarone: formation of glutathione adducts from a catechol ...
https://pubmed.ncbi.nlm.nih.gov/18020424/?dopt=Abstract
Benzbromarone manufacturer with low price price,buy Formaldehyde,Formaldehyde supplier-Hangzhou JINLAN Pharm-Drugs Technology...Benzbromarone manufacturer with low price price,buy Formaldehyde,Formaldehyde supplier-Hangzhou JINLAN Pharm-Drugs Technology...
... provide Benzbromarone manufacturer with low price 3562-84-3 product and the products related with China (Mainland) ... Benzbromarone manufacturer with low price 3562-84-3 Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd China (Mainland) ... Benzbromarone manufacturer with low price CAS NO.3562-84-3. Min.Order Quantity: 1 Gram. Purity: 99%. Port: shanghai. Payment ... Benzbromarone is a uricosuric agent and non-competitive inhibitor of xanthine oxidase used in the treatment of gout, especially ...
https://www.lookchem.com/product_Benzbromarone-manufacturer-with-low-price/24371354.html
Efficacy and tolerability of urate-lowering drugs in gout: a randomised controlled trial of benzbromarone versus probenecid...Efficacy and tolerability of urate-lowering drugs in gout: a randomised controlled trial of benzbromarone versus probenecid...
The success ratio benzbromarone:probenecid was 1.42 (95% CI 1.07 to 1.89). With benzbromarone 200 mg/day, the sUr concentration ... Benzbromarone was withdrawn from the market in Europe in 2003, but was registered again in some countries in 2004.11 Its use is ... Efficacy of benzbromarone compared to allopurinol in lowering serum urate level in hyperuricemic patients. J Med Assoc Thai ... It seems that benzbromarone is a highly efficacious oral sUr-lowering drug that has been excessively withdrawn from the market ...
https://ard.bmj.com/content/68/1/51?ijkey=1786b2aaa7bdb3b8aa13f3730e82aa430a8c137b&keytype2=tf_ipsecsha
A randomised controlled trial on the efficacy and tolerability with dose escalation of allopurinol 300-600 mg/day versus...A randomised controlled trial on the efficacy and tolerability with dose escalation of allopurinol 300-600 mg/day versus...
Severe hepatotoxicity caused by benzbromarone is seen in rare cases, and has led to withdrawal of benzbromarone in many ... For benzbromarone, the reduction in sUr from baseline was 42 (15)% with the 100 mg/day dose and 46 (8)% with the 200 mg/day. ... Treatment success with benzbromarone was increased from 52% to 78% by titrating the dose up to 200 mg/day (p = 0.075). The ... Efficacy of benzbromarone compared to allopurinol in lowering serum urate level in hyperuricemic patients. J Med Assoc Thai ...
https://ard.bmj.com/content/68/6/892?ijkey=f4ddcdbf22837d61c1c577005877658fbb2488f8&keytype2=tf_ipsecsha
Safety, Efficacy of Citrate Mixture vs Sodium Bicarbonate in Patients With Gout Receiving Benzbromarone - Renal and Urology NewsSafety, Efficacy of Citrate Mixture vs Sodium Bicarbonate in Patients With Gout Receiving Benzbromarone - Renal and Urology News
... and safety of citrate mixture and sodium bicarbonate on urine alkalization in patients with gout receiving benzbromarone. ... In addition, benzbromarone was administered initially at a 25-mg/day dose, then maintained at a dose of 50 mg/day, along with ... Close more info about Safety, Efficacy of Citrate Mixture vs Sodium Bicarbonate in Patients With Gout Receiving Benzbromarone ... Close more info about Safety, Efficacy of Citrate Mixture vs Sodium Bicarbonate in Patients With Gout Receiving Benzbromarone ...
https://www.renalandurologynews.com/home/news/nephrology/hyperuricemia/safety-efficacy-of-citrate-mixture-vs-sodium-bicarbonate-in-gout-with-benzbromarone/
Transport of diclofenac by BCRP (ABCG2) and stimulation of MRP2- (ABCC2-) mediated drug transport by diclofenac and...Transport of diclofenac by BCRP (ABCG2) and stimulation of MRP2- (ABCC2-) mediated drug transport by diclofenac and...
... mediated drug transport by diclofenac and benzbromarone. Jurjen S. Lagas, Cornelia M. van der Kruijssen, Koen van de Wetering, ... mediated drug transport by diclofenac and benzbromarone. Jurjen S. Lagas, Cornelia M. van der Kruijssen, Koen van de Wetering, ... mediated drug transport by diclofenac and benzbromarone. Jurjen S. Lagas, Cornelia M. van der Kruijssen, Koen van de Wetering, ... mediated drug transport by diclofenac and benzbromarone ...
https://dmd.aspetjournals.org/content/early/2008/10/09/dmd.108.023200?versioned=true
Benzbromarone - dot1linhibitor.comBenzbromarone - dot1linhibitor.com
Benzbromarone. Post date. June 29, 2017. Post last updated dateUpdated Post read time. 24 sec read Post author. DOT1L Inhibitor ... Product Name: Benzbromarone. Purity: 98.00%. CAS NO:1218779-75-9 Product: Apatinib Product Dsecription: Uricosuric that acts by ...
https://www.dot1linhibitor.com/2017/06/29/Benzbromarone/
Benzbromarone | CAS#3562-84-3 | MedKooBenzbromarone | CAS#3562-84-3 | MedKoo
Benzbromarone is highly effective and well tolerated, and clinical trials as early as 1981 and as recently as April 2008 have ... Benzbromarone is a uricosuric agent and non-competitive inhibitor of xanthine oxidase used in the treatment of gout, especially ... Benzbromarone, purity , 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and ... Benzbromarone is highly effective and well tolerated, and clinical trials as early as 1981 and as recently as April 2008 have ...
https://www.medkoo.com/products/10738
Stronger Uricosuric Effects of the Novel Selective URAT1 Inhibitor UR-1102 Lowered Plasma Urate in Tufted Capuchin Monkeys to a...Stronger Uricosuric Effects of the Novel Selective URAT1 Inhibitor UR-1102 Lowered Plasma Urate in Tufted Capuchin Monkeys to a...
14C]UR-1102 and [14C]benzbromarone were synthesized at Korea RadioChemicals Center (Suwon, Republic of Korea). Benzbromarone ... benzbromarone significantly inhibited OAT1 and OAT3 but UR-1102 did not, since the Ki values of benzbromarone and UR-1102 for ... 1 for benzbromarone. To confirm the validity of the dose selection and to examine the PK profiles of UR-1102 and benzbromarone ... and 30 mg/kg and by benzbromarone at 10, 30, and 100 mg/kg, but not by 3 mg/kg benzbromarone (Fig. 4). Comparing 30 mg/kg of UR ...
http://jpet.aspetjournals.org/content/357/1/157
Butalbital-D5 (0.1 mg/ml) in Methanol- CAS Number 145243-96-5Butalbital-D5 (0.1 mg/ml) in Methanol- CAS Number 145243-96-5
Benzbromarone. 10 mg. LGCFOR0456.00. In den Warenkorb Benzbromarone 1.0 mg/ml in Methanol. 1 mL. LGCAMP0456.00-01. In den ...
https://www.lgcstandards.com/DE/de/Butalbital-D5-0-1-mg-ml-in-Methanol/p/CERB-005
R)-(-)-Bromo-DragonFLY HCl (1.0 mg/mL) (as free base) in Methanol- CAS Number 332012-24-5R)-(-)-Bromo-DragonFLY HCl (1.0 mg/mL) (as free base) in Methanol- CAS Number 332012-24-5
Benzbromarone 1.0 mg/ml in Methanol. 1 mL. LGCAMP0456.00-01. Add to basket ...
https://www.lgcstandards.com/FR/en/-R-Bromo-DragonFLY-HCl-1-0-mg-mL-as-free-base-in-Methanol/p/CERB-049
Products in Biologically Active Small Molecules, Cayman Chemical, UN2811 on Thomas ScientificProducts in Biologically Active Small Molecules, Cayman Chemical, UN2811 on Thomas Scientific
Benzbromarone Cayman Chemical. An inhibitor of URAT1 (IC50 = 0.3 µM for hURAT1) that prevents renal urate resorption; also ...
https://www.thomassci.com/nav/cat1/biologicallyactivesmallmolecules/manufacturer/caymanchemical/unnumber/un2811/0
The prevalence of hyperuricemia and its correlates in Ganzi Tibetan Autonomous Prefecture, Sichuan Province, China |...The prevalence of hyperuricemia and its correlates in Ganzi Tibetan Autonomous Prefecture, Sichuan Province, China |...
Background Hyperuricemia is a common and serious public health problem. There has been no broad epidemiological survey of hyperuricemia in China, especially in Tibetan area. This study was therefore...
https://link.springer.com/article/10.1186%2Fs12944-018-0882-6
Warfarin (Oral Route) Proper Use - Mayo ClinicWarfarin (Oral Route) Proper Use - Mayo Clinic
Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery or medical tests. Check with your doctor immediately if you have diarrhea, fever, or any symptoms of an infection. This medicine may cause skin necrosis or gangrene. Call your doctor right away if you have pain, a color change, or a temperature change to any area of your body. Call your doctor right away if you have pain in your toes and they look purple or dark in color. These could be signs of a serious medical problem. Calciphylaxis or calcium uremic arteriolopathy may occur in patients with or without end-stage kidney disease. Tell your doctor right away if you have purplish red, net-like, blotchy spots on the skin. This medicine may increase your chance of bleeding. Check with your doctor right away if you notice any unusual bleeding or bruising, black, tarry stools, blood in the urine or stools, or pinpoint red spots on your ...
https://www.mayoclinic.org/drugs-supplements/warfarin-oral-route/proper-use/DRG-20070945?p=1
Hereditary Coproporphyria Treatment & Management: Approach Considerations, DietHereditary Coproporphyria Treatment & Management: Approach Considerations, Diet
Benzbromarone [Benzylthiouracil] [Bepridil] Bromocriptine Busulphan *Butylscopolamine Captopril *Carbamazepine *Carbromal * ...
https://emedicine.medscape.com/article/205374-treatment
Acute Intermittent Porphyria: Practice Essentials, Pathophysiology, EpidemiologyAcute Intermittent Porphyria: Practice Essentials, Pathophysiology, Epidemiology
Acute intermittent porphyria (AIP) is one of the porphyrias, a group of diseases involving defects in heme metabolism and that results in excessive secretion of porphyrins and porphyrin precursors. AIP manifests itself by abdomen pain, neuropathies, and constipation, but, unlike most types of porphyria, patients with AIP do not have a rash.
https://emedicine.medscape.com/article/205220-overview
Warfarin (Intravenous Route) Before Using - Mayo ClinicWarfarin (Intravenous Route) Before Using - Mayo Clinic
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.. ...
https://www.mayoclinic.org/drugs-supplements/warfarin-intravenous-route/before-using/drg-20071147
Search of: Recruiting, Not yet recruiting, Available Studies | Gout - List Results - ClinicalTrials.govSearch of: Recruiting, Not yet recruiting, Available Studies | 'Gout' - List Results - ClinicalTrials.gov
Drug: benzbromarone. Interventional. Phase 2. *Jiangsu HengRui Medicine Co., Ltd.. Industry. *Allocation: Randomized ...
https://clinicaltrials.gov/ct2/results?recr=Open&cond=%22Gout%22
Pujo J[au] - PubMed - NCBIPujo J[au] - PubMed - NCBI
Mechanisms of action of benzbromarone. Study in 3 anephric subjects. Preliminary results in 3 cases]. ...
https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Pujo+J%5Bau%5D&dispmax=50
Effect of urate-lowering therapy on the velocity of size reduction of tophi in chronic goutEffect of urate-lowering therapy on the velocity of size reduction of tophi in chronic gout
Allopurinol and benzbromarone are equally effective when optimal serum urate levels are achieved during therapy. Combined ... Results: Patients taking benzbromarone alone or combined allopurinol and benzbromarone therapy achieved faster velocity of ... Allopurinol and benzbromarone are equally effective when optimal serum urate levels are achieved during therapy. Combined ... Method: Sixty-three patients with crystal-confirmed tophaceous gout were treated with allopurinol, benzbromarone, or combined ...
https://pubmed.ncbi.nlm.nih.gov/12209479/?dopt=Abstract
The year that was 2013 - BPJ 58 February 2014The year that was 2013 - BPJ 58 February 2014
Benzbromarone now available in New Zealand. Benzbromarone is a uricosuric medicine which has been used in other countries for ... Like benzbromarone, it is safe to use in patients with mild to moderate renal impairment, but it also associated with ... Benzbromarone can be used safely for patients with moderate renal impairment and may be more effective than allopurinol in ... However, benzbromarone has been associated with liver toxicity, and patients must have regular liver function tests as part of ...
https://bpac.org.nz/BPJ/2014/February/year2013.aspx
Allopurinol - Drugs.comAllopurinol - Drugs.com
Allomaron (Allopurinol and Benzbromarone). Natrapharm, Philippines. *Allonol. Ratiopharm, Iceland. *Allopac. Pacific Pharma, ...
https://www.drugs.com/international/allopurinol.html
Drug Metabolism Letters, Volume 10 - Number 1Drug Metabolism Letters, Volume 10 - Number 1
Inactivation of CYP3A4 by Benzbromarone in Human Liver Microsomes , 10(1): 16 - 21. Yasuhiro Masubuchi and Shinji Kondo. DOI: ...
https://benthamscience.com/journals/drug-metabolism-letters/volume/10/issue/1/
uric acid in blood - best uric acid in blooduric acid in blood - best uric acid in blood
benzbromarone CAS 3562-84-3 AzubroMaron，Pharmaceutical Grade Chemicals. MOSINTER GROUP LIMITED [Zhejiang] ...
http://www.phrmg.org/buy-uric-acid-in-blood
Plus itPlus it
Hypouricemic Effects of Dotinurad and Benzbromarone in Cebus Monkeys.. Effects of dotinurad and benzbromarone on plasma urate ... On the contrary, benzbromarone, at a dose of 30 mg/kg, showed a modest effect on plasma urate levels. The inhibitory effect of ... On the contrary, benzbromarone increased the urinary urate excretion to 19.4 mg at a dose of 30 mg/kg. Results of creatinine ... Benzbromarone inhibited xanthine oxidase activity with an IC50 value of 15.4 μM. Dotinurad, lesinurad, and probenecid did not ...
http://jpet.aspetjournals.org/content/371/1/162
Unapproved medicines and unapproved uses of medicines - BPJ Issue 51Unapproved medicines and unapproved uses of medicines - BPJ Issue 51
Benzbromarone is an unapproved, but subsidised medicine. Benzbromarone has been used for the treatment of gout in other ... an unapproved version of benzbromarone for the treatment of gout. Benzbromarone is to be listed on the Pharmaceutical Schedule ... Benzbromarone was initially funded by PHARMAC for some patients under one or more of its exceptions schemes, which allow ... However, following positive reviews of benzbromarone by PHARMACs advisory committees, and in the absence of availability of an ...
https://bpac.org.nz/bpj/2013/march/unapproved-medicines.aspx
Allopurinol and benzbromaroneProbenecid and benzbromaroneUricosuric agentAnother uricosuric drugMetabolismTreated with allopurinolEfficacyWhereas benzbromaroneFebuxostatHyperuricemiaWithdrawn from the marketInhibitorUric acid levelsCytochrome P450ChronicSulfinpyrazoneDrugsHypouricemicPatientsRenal1970sSignificantlyUrate levelsCompoundsInhibitorsToxicityTransporterDerivativesIdentificationTreatmentCombinationEffectiveType
Allopurinol and benzbromarone5
  • Efficacy of allopurinol and benzbromarone for the control of hyperuricaemia. (wikipedia.org)
  • Patients taking benzbromarone alone or combined allopurinol and benzbromarone therapy achieved faster velocity of reduction of tophi than patients taking allopurinol alone. (nih.gov)
  • Allopurinol and benzbromarone are equally effective when optimal serum urate levels are achieved during therapy. (nih.gov)
  • Conclusion We found that the use of allopurinol and benzbromarone, whether alone or in combination, had a linear dose-response relationship between the numbers of defined daily doses and the risk of CAD, especially in higher DDDs. (elsevier.com)
  • GAE and GAW were administered orally at different doses to hyperuricemia mice, while allopurinol and benzbromarone served as positive controls. (frontiersin.org)
Probenecid and benzbromarone2
  • These are oral medicines and include probenecid and benzbromarone. (cnn.com)
  • Uricosuric drugs (i.e., probenecid and benzbromarone) that reduce the serum uric acid concentration (SUA) by increasing the renal excretion of uric acid and xanthine oxidase inhibitors (i.e., allopurinol) that decrease serum uric acid by inhibiting uric acid synthesis have been the mainstays of conventional HUE treatment [ 8 ]. (hindawi.com)
Uricosuric agent4
  • Benzbromarone is a uricosuric agent and non-competitive inhibitor of xanthine oxidase used in the treatment of gout, especially when allopurinol, a first-line treatment, fails or produces intolerable adverse effects. (wikipedia.org)
  • Benzbromarone (BBR) is a uricosuric agent that has been used as a treatment for chronic gout. (nih.gov)
  • 8: Manger B. [Uricosuric agent benzbromarone vs. allopurinol: comparable effect]. (medkoo.com)
  • 1) Benzbromarone administration experiment: benzbromarone (an uricosuric agent) was administered orally the day before exercise. (biomedsearch.com)
Another uricosuric drug1
  • Benzbromarone is highly effective and well tolerated, and clinical trials as early as 1981 and as recently as April 2008 have suggested it is superior to both allopurinol, a non-uricosuric xanthine oxidase inhibitor, and probenecid, another uricosuric drug. (wikipedia.org)
Metabolism1
  • The metabolism of (R)-warfarin can be decreased when combined with Benzbromarone. (drugbank.ca)
Treated with allopurinol2
  • Sixty-three patients with crystal-confirmed tophaceous gout were treated with allopurinol, benzbromarone, or combined therapy to achieve serum uric acid levels less than the threshold for saturation of urate in tissues. (nih.gov)
  • Results Of 8047 gout patients, 1422 were treated with allopurinol (Group A), 4141 with benzbromarone (Group B), and 2484 with both drugs (Group A/B) during the follow-up period. (elsevier.com)
Efficacy6
  • To investigate the efficacy and tolerability of allopurinol as the first-choice antihyperuricaemic treatment for gout, and compare the efficacy and tolerability of benzbromarone and probenecid as second-choice treatment. (bmj.com)
  • Given the scarce clinical trial data, it remains questionable whether the efficacy-safety balance of benzbromarone and probenecid is unfavourable compared with the first choice treatment, allopurinol. (bmj.com)
  • To compare the efficacy and tolerability of allopurinol 300-600 mg/day versus benzbromarone 100-200 mg/day used to attain a target serum urate concentration (sUr) ⩽0.30 mmol/l (5 mg/dl). (bmj.com)
  • Researchers sought to compare the safety and efficacy of citrate mixture and sodium bicarbonate on urine alkalization in patients with gout receiving treatment with benzbromarone. (renalandurologynews.com)
  • In 2014, a panel of 78 international rheumatologists raised ten key clinical questions pertinent to the diagnosis and management of gout, and one of these questions was how to determine the efficacy, cost-efficacy and safety of ULT (allopurinol, benzbromarone, febuxostat, peg-uricase and probenecid) in the treatment of gout 22 . (nature.com)
  • Efficacy of benzbromarone in hyperuricemic patients associated with chronic kidney disease. (thefreedictionary.com)
Whereas benzbromarone1
  • Dotinurad had no effect on urate secretion transporters in vivo, whereas benzbromarone, lesinurad, probenecid, and febuxostat increased the plasma concentrations of probe substrates. (aspetjournals.org)
Febuxostat3
  • We systematically reviewed fifteen randomized controlled trials (involving 7,246 patients through January 2016) that compared the effects of different urate-lowering drugs (allopurinol, benzbromarone, febuxostat, pegloticase and probenecid) on hyperuricemia. (nature.com)
  • Our findings show that febuxostat, benzbromarone, probenecid, pegloticase, and allopurinol were all highly effective at reducing the risk of hyperuricemia compared to placebo. (nature.com)
  • Tophi can be treated with urate-lowering drugs (e.g. benzbromarone, probenecid, allopurinol, febuxostat, pegloticase), surgical removal or other interventions such as haemodialysis. (cochrane.org)
Hyperuricemia2
  • Benzbromarone has been used in trials studying the basic science and treatment of Heart Failure, Hyperuricemia, Chronic Kidney Disease, Abnormal Renal Function, and Gout and Asymptomatic Hyperuricemia. (drugbank.ca)
  • Its effects were similar with that of benzbromarone , but with no significant effect on XOD and urinary volume of chronic hyperuricemia rats. (curehunter.com)
Withdrawn from the market2
  • Benzbromarone was withdrawn from the market in Europe in 2003, but was registered again in some countries in 2004. (bmj.com)
  • Of importance, two drugs (troglitazone and benzbromarone), previously withdrawn from the market because of liver injury, are among the potent repressors. (sigmaaldrich.com)
Inhibitor1
  • Benzbromarone is a very potent inhibitor of CYP2C9. (wikipedia.org)
Uric acid levels1
  • Benzbromarone appears to reduce uric acid levels to a similar degree than allopurinol in patients with chronic gout. (essentialevidenceplus.com)
Cytochrome P4501
  • 7: Kitagawara Y, Ohe T, Tachibana K, Takahashi K, Nakamura S, Mashino T. Novel Bioactivation Pathway of Benzbromarone Mediated by Cytochrome P450. (medkoo.com)
Chronic1
  • Chronic application of benzbromarone in two independent animal models significantly decreased right ventricular pressure and reversed remodelling of established pulmonary hypertension. (ersjournals.com)
Sulfinpyrazone3
  • Uricosuric agents such as probenecid and sulfinpyrazone can be used as alternatives, and benzbromarone is only recommended in patients with mild to moderate renal insufficiency. (bmj.com)
  • Miner noted that current uricosuric agents such as benzbromarone, probenecid, and sulfinpyrazone are either not available in certain areas of the world because of adverse side effects or are not used by doctors because of their side effects. (medpagetoday.com)
  • probenecid, 500 to 1,000 mg twice daily, or sulfinpyrazone, 50 to 400 mg twice daily or benzbromarone, 25 to 120 mg daily. (aafp.org)
Drugs2
  • This study examined the changes in risk of CAD in gout patients taking allopurinol and/or benzbromarone, and analyzed the dose-response relationship of both drugs with CAD incidence. (elsevier.com)
  • Benzofuran fragment is present in many pharmaceutical substances such as antiarrhythmic medications (Amiodarone and Dronedarone), medications for psoriasis and gout (Benzbromarone and Benziodarone), drugs for the treatment of sleep disorders (Heltioz) and skin diseases (Psoralen and Trioxalen) as well as some antidepressants. (eurekalert.org)
Hypouricemic1
  • The hypouricemic effects of dotinurad and benzbromarone were evaluated in Cebus monkeys. (aspetjournals.org)
Patients7
  • Those patients who could not tolerate allopurinol or who did not attain the target serum urate concentration (sUr) ⩽0.30 mmol/l (5.0 mg/dl), which was defined as successful, were randomised to benzbromarone 200 mg/day or probenecid 2 g/day for another 2 months (stage 2). (bmj.com)
  • 27 patients received benzbromarone (3 patients not eligible for analysis) and 35 received probenecid (4 patients not eligible for analysis). (bmj.com)
  • Treatment with benzbromarone was successful in 22/24 patients (92%) and with probenecid in 20/31 patients (65%) (p = 0.03 compared with benzbromarone). (bmj.com)
  • Patients were treated with 300 mg allopurinol or 100 mg benzbromarone once a day (stage 1). (bmj.com)
  • Two patients stopped receiving allopurinol and three stopped receiving benzbromarone because of adverse drug reactions. (bmj.com)
  • Cox proportional hazard ratio was used to compare the risk of CAD in gout patients taking allopurinol or/and benzbromarone with those taking neither drug. (elsevier.com)
  • Studies have shown that, where it is available, benzbromarone can be more effective than probenecid or allopurinol in helping patients avoid gout. (goutpal.com)
Renal1
  • Allopurinol was no option because of intolerance, while benzbromarone was ineffective because of renal impairment. (hindawi.com)
1970s2
  • Benzbromarone was introduced in the 1970s and was viewed as having few associated serious adverse reactions. (wikipedia.org)
  • Since the introduction of benzbromarone in the early 1970s, three cases of severe hepatitis have been published. (bmj.com)
Significantly2
  • Increasing the allopurinol dose from 300 to 600 mg/day and the benzbromarone dose from 100 to 200 mg/day according to the target sUr produced significantly higher success rates (both 78% successful in attaining sUr ⩽0.30 mmol/l). (bmj.com)
  • However, after adjustment for covariates in dose-response analyses, treatment with over 270 defined daily doses (DDDs) of allopurinol, and over 360 DDDs of benzbromarone, was associated with a significantly reduced risk of CAD. (elsevier.com)
Urate levels1
  • On the contrary, benzbromarone, at a dose of 30 mg/kg, showed a modest effect on plasma urate levels. (aspetjournals.org)
Compounds1
  • Interestingly, three of the compounds analyzed-benzbromarone, quercetin, and folic acid-are able to slow down amylin fiber formation according to Thioflavin T binding, turbidimetry, and Transmission Electron Microscopy assays. (mdpi.com)
Inhibitors1
  • Niclosamide, benzbromarone and Ani9 also affected TMEM16F whole cell currents, indicating limited specificity for these inhibitors. (physiciansweekly.com)
Toxicity2
  • Benzbromarone, for example, was not marketed in the U.S. and in parts of Europe because the drug is associated with fatal liver toxicity. (medpagetoday.com)
  • The gout medicine "benzbromarone" is a uricosuric drug that was approved in the 1970's for use in many countries in Europe, Asia, and South America…but not in the United States, due to concerns about liver toxicity. (thegoutkiller.com)
Transporter1
  • Role of the OATP Transporter Family and a Benzbromarone-SensitiveEfflux Transporter in the Hepatocellular Disposition of Vincristine. (uzh.ch)
Derivatives2
  • Structure-activity relationships of benzbromarone metabolites and derivatives as EYA inhibitory anti-angiogenic agents. (nih.gov)
  • Benzbromarone metabolites and derivatives function as EYA3 inhibitory anti-angiogenic agents. (nih.gov)
Identification1
  • 4: Wang K, Wang H, Peng Y, Zheng J. Identification of Epoxide-Derived Metabolite(s) of Benzbromarone. (medkoo.com)
Treatment2
  • A benefit-risk assessment of benzbromarone in the treatment of gout. (wikipedia.org)
  • No significant differences in treatment success between benzbromarone and allopurinol were found after dose escalation. (bmj.com)
Combination1
  • Researchers injected trees in greenhouses and fields with solutions of benzbromarone, tolfenamic acid and a combination of the two. (thepacker.com)
Effective1
  • In stage 2, benzbromarone 200 mg/day was more effective and better tolerated than probenecid 2 g/day. (bmj.com)
Type1
  • The three well-known blockers benzbromarone, niclosamide, and Ani9 inhibited both TMEM16A and ATP-induced Ca increase by variable degrees, depending on the cell type. (physiciansweekly.com)
Stronger Uricosuric Effects of the Novel Selective URAT1 Inhibitor UR-1102 Lowered Plasma Urate in Tufted Capuchin Monkeys to a...
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The year that was 2013 - BPJ 58 February 2014
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Plus it
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Unapproved medicines and unapproved uses of medicines - BPJ Issue 51
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Comparative efficacy and safety of urate-lowering therapy for the treatment of hyperuricemia: a systematic review and network...
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Frontiers | Hypouricemic Effects of Ganoderma applanatum in Hyperuricemia Mice through OAT1 and GLUT9 | Pharmacology
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Lesinurad in combination with allopurinol: results of a phase 2, randomised, double-blind study in patients with gout with an...
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Meyler's Side Effects of Drugs - Elsevier Science & Technology - Literati by Credo
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Solute carrier organic anion transporter family member 2B1 - DrugBank
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Use of HLA-B*58:01 genotyping to prevent allopurinol induced severe cutaneous adverse reactions in Taiwan: national prospective...
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Aspirin and Dipyridamole (Professional Patient Advice) - Drugs.com
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Safety, Efficacy of Citrate Mixture vs Sodium Bicarbonate in Patients With Gout Receiving Benzbromarone - Renal and Urology News
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Best Practice Bulletin: Issue 1 - bpacnz
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Do I have gout or tendinitis? - The Chart - CNN.com Blogs
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EULAR: New Gout Fighters in Development | Medpage Today
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Purine and Pyrimidine Metabolism in Man VIII | SpringerLink
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Gout Medication Is a Last Resort | Keep It Real, Stay Healthy!
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Efficacy of allopurinol and benzbromarone for the control of hyperuricaemia. A pathogenic approach to the treatment of primary...
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Gout and Pseudogout Treatment & Management: Approach Considerations, Treatment of Acute Attacks, Treatment of Chronic Gout
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