Benperidol: A butyrophenone with general properties similar to those of HALOPERIDOL. It has been used in the treatment of aberrant sexual behavior. (From Martindale, The Extra Pharmacopoeia, 30th ed, p567)Receptors, Dopamine D2: A subfamily of G-PROTEIN-COUPLED RECEPTORS that bind the neurotransmitter DOPAMINE and modulate its effects. D2-class receptor genes contain INTRONS, and the receptors inhibit ADENYLYL CYCLASES.Oxycodone: A semisynthetic derivative of CODEINE.Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)Physician-Patient Relations: The interactions between physician and patient.United States Food and Drug Administration: An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.Phytotherapy: Use of plants or herbs to treat diseases or to alleviate pain.Drugs, Chinese Herbal: Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China.United StatesChlorpheniramine: A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than PROMETHAZINE.Codeine: An opioid analgesic related to MORPHINE but with less potent analgesic properties and mild sedative effects. It also acts centrally to suppress cough.Histamine H1 Antagonists: Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood.Drug Information Services: Services providing pharmaceutic and therapeutic drug information and consultation.Receptors, Histamine H1: A class of histamine receptors discriminated by their pharmacology and mode of action. Most histamine H1 receptors operate through the inositol phosphate/diacylglycerol second messenger system. Among the many responses mediated by these receptors are smooth muscle contraction, increased vascular permeability, hormone release, and cerebral glyconeogenesis. (From Biochem Soc Trans 1992 Feb;20(1):122-5)Butyrophenones: Compounds containing phenyl-1-butanone.Dimethindene: A histamine H1 antagonist. It is used in hypersensitivity reactions, in rhinitis, for pruritus, and in some common cold remedies.Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.Oxymorphone: An opioid analgesic with actions and uses similar to those of MORPHINE, apart from an absence of cough suppressant activity. It is used in the treatment of moderate to severe pain, including pain in obstetrics. It may also be used as an adjunct to anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1092)Analgesics, Non-Narcotic: A subclass of analgesic agents that typically do not bind to OPIOID RECEPTORS and are not addictive. Many non-narcotic analgesics are offered as NONPRESCRIPTION DRUGS.Analgesics, Opioid: Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS.Hydrocodone: Narcotic analgesic related to CODEINE, but more potent and more addicting by weight. It is used also as cough suppressant.Phenothiazines: Compounds containing dibenzo-1,4-thiazine. Some of them are neuroactive.Administration, Rectal: The insertion of drugs into the rectum, usually for confused or incompetent patients, like children, infants, and the very old or comatose.Prescription Drug Misuse: Improper use of drugs or medications outside the intended purpose, scope, or guidelines for use. This is in contrast to MEDICATION ADHERENCE, and distinguished from DRUG ABUSE, which is a deliberate or willful action.Suppositories: Medicated dosage forms that are designed to be inserted into the rectal, vaginal, or urethral orifice of the body for absorption. Generally, the active ingredients are packaged in dosage forms containing fatty bases such as cocoa butter, hydrogenated oil, or glycerogelatin that are solid at room temperature but melt or dissolve at body temperature.Protective Devices: Devices designed to provide personal protection against injury to individuals exposed to hazards in industry, sports, aviation, or daily activities.Tranquilizing Agents: A traditional grouping of drugs said to have a soothing or calming effect on mood, thought, or behavior. Included here are the ANTI-ANXIETY AGENTS (minor tranquilizers), ANTIMANIC AGENTS, and the ANTIPSYCHOTIC AGENTS (major tranquilizers). These drugs act by different mechanisms and are used for different therapeutic purposes.Administration, Oral: The giving of drugs, chemicals, or other substances by mouth.Copyright: It is a form of protection provided by law. In the United States this protection is granted to authors of original works of authorship, including literary, dramatic, musical, artistic, and certain other intellectual works. This protection is available to both published and unpublished works. (from Circular of the United States Copyright Office, 6/30/2008)Piperidines: A family of hexahydropyridines.Receptors, Phencyclidine: Specific sites or molecular structures on cell membranes or in cells with which phencyclidine reacts or to which it binds to elicit the specific response of the cell to phencyclidine. Studies have demonstrated the presence of multiple receptor sites for PCP. These are the PCP/sigma site, which binds both PCP and psychotomimetic opiates but not certain antipsychotics, and the PCP site, which selectively binds PCP analogs.Pipecolic AcidsReceptors, sigma: A class of cell surface receptors recognized by its pharmacological profile. Sigma receptors were originally considered to be opioid receptors because they bind certain synthetic opioids. However they also interact with a variety of other psychoactive drugs, and their endogenous ligand is not known (although they can react to certain endogenous steroids). Sigma receptors are found in the immune, endocrine, and nervous systems, and in some peripheral tissues.Phencyclidine: A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to KETAMINE in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE). As a drug of abuse, it is known as PCP and Angel Dust.Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Etidocaine: A local anesthetic with rapid onset and long action, similar to BUPIVACAINE.Anesthetics, Local: Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.Dibucaine: A local anesthetic of the amide type now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted to spinal anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1006)Halofenate: An antihyperlipoproteinemic agent and uricosuric agent.Anesthesia, Spinal: Procedure in which an anesthetic is injected directly into the spinal cord.Bupivacaine: A widely used local anesthetic agent.Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.Enflurane: An extremely stable inhalation anesthetic that allows rapid adjustments of anesthesia depth with little change in pulse or respiratory rate.Anesthetics, Inhalation: Gases or volatile liquids that vary in the rate at which they induce anesthesia; potency; the degree of circulation, respiratory, or neuromuscular depression they produce; and analgesic effects. Inhalation anesthetics have advantages over intravenous agents in that the depth of anesthesia can be changed rapidly by altering the inhaled concentration. Because of their rapid elimination, any postoperative respiratory depression is of relatively short duration. (From AMA Drug Evaluations Annual, 1994, p173)Databases, Chemical: Databases devoted to knowledge about specific chemicals.Anesthesia, Inhalation: Anesthesia caused by the breathing of anesthetic gases or vapors or by insufflating anesthetic gases or vapors into the respiratory tract.Anesthetics: Agents that are capable of inducing a total or partial loss of sensation, especially tactile sensation and pain. They may act to induce general ANESTHESIA, in which an unconscious state is achieved, or may act locally to induce numbness or lack of sensation at a targeted site.Halothane: A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. NITROUS OXIDE is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required. (From AMA Drug Evaluations Annual, 1994, p178)Isoflurane: A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.Polypharmacology: The design or use of pharmaceutical agents that act on multiple targets or disease pathways.Databases, Pharmaceutical: Databases devoted to knowledge about PHARMACEUTICAL PRODUCTS.Pharmacoepidemiology: The science concerned with the benefit and risk of drugs used in populations and the analysis of the outcomes of drug therapies. Pharmacoepidemiologic data come from both clinical trials and epidemiological studies with emphasis on methods for the detection and evaluation of drug-related adverse effects, assessment of risk vs benefit ratios in drug therapy, patterns of drug utilization, the cost-effectiveness of specific drugs, methodology of postmarketing surveillance, and the relation between pharmacoepidemiology and the formulation and interpretation of regulatory guidelines. (Pharmacoepidemiol Drug Saf 1992;1(1); J Pharmacoepidemiol 1990;1(1))Drug Utilization: The utilization of drugs as reported in individual hospital studies, FDA studies, marketing, or consumption, etc. This includes drug stockpiling, and patient drug profiles.

Imaging of striatal dopamine D(2) receptors with a PET system for small laboratory animals in comparison with storage phosphor autoradiography: a validation study with (18)F-(N-methyl)benperidol. (1/10)

Several groups have developed high-resolution PET systems and shown the feasibility of in vivo studies on small laboratory animals. In this investigation, one of these systems was validated for the performance of receptor imaging studies. For this, the radiotracer concentrations obtained in the same animals with PET and with autoradiography were quantified, and the correspondence between both methods was assessed by means of correlation analysis. METHODS: Striatal radioactivity was measured in 10 Sprague-Dawley rats after injection of 60 +/- 10 MBq of the dopamine D(2) receptor ligand (18)F-(N-methyl)benperidol in 6 time frames of 6 min each. On completion of the scans, animals were killed, and their brains were removed and sectioned using a cryostat microtome. Coronal slices were subjected to storage phosphor autoradiography with BaFBr:Eu(2+)-coated imaging plates. Striatal radioactivity was quantified in both modalities using region-of-interest analysis and activity standards. RESULTS: After partial-volume correction, the median of striatal radioactivity concentration measured with PET was 0.40 MBq/cm(3) (25th percentile, 0.32; 75th percentile, 0.44). Radioactivity concentrations determined by means of storage phosphor autoradiography amounted to 0.42 MBq/cm(3) (25th percentile, 0.24; 75th percentile, 0.51). Correlation of striatal radioactivity values yielded a Pearson correlation coefficient of 0.818 (P = 0.002). Radioactivity accumulation in Harder's glands led to an overestimation of striatal activity concentrations by approximately 5%. The median of striatal radioactivity concentration after spillover correction decreased slightly to 0.38 MBq/cm(3) (25th percentile, 0.30; 75th percentile, 0.43). Correlation of striatal radioactivity values after spillover correction yielded a Pearson correlation coefficient of 0.824 (P = 0.002). CONCLUSION: The results show a significant positive correlation between radioactivity values obtained with PET and storage phosphor autoradiography used as the gold standard. Because we applied a selective dopamine D(2) receptor radioligand and because radioactivity concentrations could be reliably quantified in the target region, we may infer that in vivo receptor binding studies will be possible in small laboratory animals.  (+info)

In vivo measurement of D2 receptor density and affinity for 18F-(3-N-methyl)benperidol in the rat striatum with a PET system for small laboratory animals. (2/10)

A recent investigation showed that intracerebral radioactivity concentrations can reliably be quantified in vivo with a small-animal PET device. The purpose of the current study was to investigate the binding characteristics of the D(2) receptor radioligand (18)F-(3-N-methyl)benperidol ((18)FMB) in rat striatum by determining receptor density (B(max)) and affinity (K(d)) in vivo. For validation, K(d) and B(max) additionally were determined in vitro using storage phosphor autoradiography. METHODS: Striatal radioactivity was measured with PET in 8 Sprague-Dawley rats after injection of (18)FMB in increasing specific activities. Free radioligand concentrations were estimated from cortical radioactivity concentrations and were subtracted from striatal radioactivity concentrations to obtain specific binding. In vitro saturation experiments were performed on 7 further rats according to the isotopic dilution method. Specific binding was determined by both subtraction of (18)FMB binding in the presence of raclopride and subtraction of cortical radioactivity concentrations from total radioligand binding. Saturation binding curves were obtained by plotting specifically bound radioligand concentrations against free radioligand concentrations and were evaluated with regression analysis. RESULTS: PET yielded a K(d) of 6.2 nmol/L and a B(max) of 16 fmol/mg for the striatal D(2) receptor. In vitro, K(d) and B(max) amounted to 4.4 nmol/L and 84.1 fmol/mg (subtraction of (18)FMB binding in the presence of raclopride), respectively, and 7.9 nmol/L and 70.1 fmol/mg (subtraction of cortical radioactivity concentrations), respectively. CONCLUSION: K(d) values measured with PET and autoradiography agreed and corresponded to inhibition constants obtained in previous in vitro studies. B(max) values lay within the same order of magnitude. The results of in vitro saturation binding analyses also agreed, irrespective of the mode of determination of free radioligand concentrations. Thus, B(max) and K(d) may be determined with PET in analogy to the evaluation of in vitro binding data by regression analysis of bound-versus-free ligand concentrations. Our results show that small-animal tomographs are valuable tools for the in vivo characterization of receptor radioligands as an alternative to autoradiography.  (+info)

Radiation dosimetry of N-([11C]methyl)benperidol as determined by whole-body PET imaging of primates. (3/10)

PURPOSE: N-([(11)C]methyl)benperidol ([(11)C]NMB) can be used for positron emission tomography (PET) measurements of D(2)-like dopamine receptor binding in vivo. We report the absorbed radiation dosimetry of i.v.-administered (11)C-NMB, a critical step before applying this radioligand to imaging studies in humans. MATERIALS AND METHODS: Whole-body PET imaging with a CTI/Siemens ECAT 953B scanner was done in a male and a female baboon. After i.v. injection of 444-1221 MBq of (11)C-NMB, sequential images taken from the head to the pelvis were collected for 3 h. Volumes of interest (VOIs) were identified that entirely encompassed small organs (whole brain, striatum, eyes, and myocardium). Large organs (liver, lungs, kidneys, lower large intestine, and urinary bladder) were sampled by drawing representative regions within the organ volume. Time-activity curves for each VOI were extracted from the PET, and organ residence times were calculated by analytical integration of a multi-exponential fit of the time-activity curves. Human radiation doses were estimated using OLINDA/EXM 1.0 and the standard human model. RESULTS: Highest retention was observed in the blood and liver, each with total residence times of 1.5 min. The highest absorbed radiation doses were to the heart (10.5 muGy/MBq) [DOSAGE ERROR CORRECTED] and kidney (9.19 muGy/MBq), [DOSAGE ERROR CORRECTED] making these the critical organs for [(11)C]NMB. A heart absorption of 50 mGy would result from an injected dose of 4,762 MBq [(11)C]NMB. CONCLUSIONS: Thus, this study suggests that up to 4,762 MBq of [(11)C]NMB can be safely administered to human subjects for PET studies. Total body dose and effective dose for [(11)C]NMB are 2.82 muGy/MBq [DOSAGE ERROR CORRECTED] and 3.7 mSv/kBq, respectively.  (+info)

Validation of the reference tissue model for estimation of dopaminergic D2-like receptor binding with [18F](N-methyl)benperidol in humans. (4/10)

 (+info)

In vivo labeling of the dopamine D2 receptor with N-11C-methyl-benperidol. (5/10)

A new dopamine D2 receptor radiotracer, N-11C-methyl-benperidol (11C-NMB), was prepared and its in vivo biologic behavior in mice and a baboon was studied. Carbon-11-NMB was determined to bind to specific sites characterized as dopamine D2 receptors. The binding was saturable, reversible, and stereospecific. Kinetic studies in the dopamine D2 receptor-rich striatum showed that 11C-NMB was retained five times longer than in receptor-devoid regions, resulting in a high maximum striatal-to-cerebellar ratio of 11:1 at 60 min after injection. From frontal cortex and cortex, on the other hand, the tracer washed out as rapidly as it did from cerebellum, resulting in tissue-to-cerebellar ratios close to one in these regions at any time after injection. Blocking studies confirmed the specificity and selectivity of the 11C-NMB binding to the dopamine D2 receptor. A PET study with 11C-NMB of the baboon brain revealed highly selective labeling of dopamine D2 receptor sites which was blocked by preinjection of raclopride.  (+info)

Characterization of extrastriatal D2 in vivo specific binding of [(1)(8)F](N-methyl)benperidol using PET. (6/10)

 (+info)

Syntheses and specific activity determinations of no-carrier-added (NCA) F-18-labeled butyrophenone neuroleptics--benperidol, haloperidol, spiroperidol, and pipamperone. (7/10)

A general method for the syntheses of no-carrier-added (NCA) 18F-labeled butyrophenone neuroleptics--benperidol, haloperidol, spiroperidol, and pipamperone is described. These 18F-labeled neuroleptic drugs are synthesized by a multistep synthesis in an overall radiochemical yield of 10-20% at end of bombardment (EOB) in a synthesis time of 90 min from EOB. The sequence involves the synthesis of NCA p-[18F]fluorobenzonitrile from NCA [18F]-fluoride and p-nitrobenzonitrile using the rapidly converted to gamma-chloro-p-[18F]fluorobutyrophenone which is alkylated with appropriate amines to give NCA 18F-labeled benperidol, haloperidol, spiroperidol, and pipamperone. The final product is purified by preparative high performance liquid chromatography (HPLC). The 18F solution used in the synthesis as determined by ion chromatography contains 15.3 +/- 9.0 nmol of stable fluoride. The specific activities of the resulting butyrophenone neuroleptics were determined to be 3 Ci/mumol (at EOB) (range 1-6 Ci/mumol) as determined by radioreceptor assay and HPLC assay.  (+info)

A comparative study of conventional premedication (pethidine, promethazine, and atropine) and neuroleptanalgesia (droperidol and phenoperidine) for peroral endoscopy. (8/10)

A double blind comparison of conventional premedication (pethidine, promethazine, and atropine) and neuroleptanalgesia (droperidol and phenoperidine) failed to demonstrate any difference in either the comfort of the patient or ease of instrumentation in 70 upper gastrointestinal tract endoscopies. Further trials are needed before conventional premedication is abandoned.  (+info)

*Benperidol

... is a drug which is a highly potent butyrophenone derivative. It is the most potent neuroleptic on the European ... Benperidol was discovered at Janssen Pharmaceutica in 1961. Timiperone has the same structure but thiourea instead of normal ... Möller; Müller; Bandelow: Neuroleptika, 2001, WVG; ISBN 3-8047-1773-X (in German) Bobon J, Collard J, Lecoq R, Benperidol and ...

*List of dopaminergic drugs

Benperidol • Bromperidol • Clopenthixol • Chlorpromazine • Chlorprothixene • Droperidol • Flupentixol • Fluphenazine • ...

*Chemical castration

But benperidol does not affect testosterone and is therefore not a castration agent. Chemical castration is often seen as an ... The antipsychotic agent benperidol is sometimes used to diminish sexual urges in people who display inappropriate sexual ...

*Risperidone

Although not a butyrophenone, it was developed with the structures of benperidol and ketanserin as a basis. It has actions at ...

*Timiperone

It is similar in chemical structure to benperidol but has a thiourea group instead of a urea group. Index Nominum 2000: ...

*Butyrophenone

Examples of butyrophenones include: Haloperidol, the most widely used classical antipsychotic drug in this class Benperidol, ...

*Morvarid Karimi

... benperidol using PET. Synapse. 2012 Sep;66(9):770-80. doi: 10.1002/syn.21566. Epub 2012 May 15. PubMed PMID 22535514; PubMed ...

*List of MeSH codes (D02)

... benperidol MeSH D02.522.352.343 --- droperidol MeSH D02.522.352.506 --- haloperidol MeSH D02.522.352.800 --- spiperone MeSH ...

*List of psychiatric medications

Benperidol, Bimaran, Bioperidolo, Biston, Brotopon, Bespar, Bupropion, Buspar, Buspimen, Buspinol, Buspirone, Buspisal, Cabaser ...

*List of drugs: Be

Benperidol (INN) Benproperine (INN) Benralizumab (INN) Benrixate (INN) Bensalan (INN) Benserazide (INN) Bensuldazic acid (INN) ...

*Dopamine antagonist

... acepromazine amisulpride amoxapine asenapine azaperone benperidol bromopride butaclamol clomipramine (mild) chlorpromazine ...

*ATC code N05

Haloperidol N05AD02 Trifluperidol N05AD03 Melperone N05AD04 Moperone N05AD05 Pipamperone N05AD06 Bromperidol N05AD07 Benperidol ...

*List of psychotropic medications

... used to relieve anxiety benperidol ( Benperidol ) - an antipsychotic primarily used to control antisocial hypersexual behaviour ...
Supplementary Materialssupplementary information 41598_2018_38159_MOESM1_ESM. PAD created with this scholarly research for UTI testing offers a fast, cost-effective diagnostic way for make use of in remote control areas. Intro In the developing globe, infectious diseases will be the most common reason behind illness, leading to a lot more than 1.2 million fatalities every year in those countries1,2. The introduction of simple, inexpensive, solid and portable point-of-care diagnostic products for the first recognition of infectious illnesses remains an immediate need for make use of purchase Ruxolitinib generally in most developing countries1C4. To hide the guidelines suggested by the Globe Health Firm (WHO)5, the perfect diagnostic test should follow the ASSURED criteria, including being affordable, sensitive, specific, user-friendly, rapid and robust, equipment-free and deliverable5. Among all the types of point of care diagnostic devices, paper-based sensors have become attractive and ...
China Gold Testing Equipment, Small Laboratory Testing Machine, Find details about China Gold Laboratory Equipment, Gold Laboratory Machine from Gold Testing Equipment, Small Laboratory Testing Machine - Ganzhou Gelin Mining Machinery Co., Ltd.
The robot incorporates the functionality of Agilents larger automated microplate handlers in a compact design for use in small laboratory spaces, enabling the automation of a variety of changing, science-driven workflows.. The Benchbot can be integrated with a range of laboratory equipment, increasing its utility for applications from next-generation sequencing and microarray sample preparation to high-throughput LC/MS sample management and cell-based assays.. The compact size of the Benchbot enables scientists to use it right where they need it most - on a bench, in a fumehood or on a docking table.. With the Benchbot robot, automated solutions move from large, specialised machines to compact, flexible robots that any scientist can use, according to the company.. The simplicity of the Benchbots one-touch programming in an application requiring the automation of sealing, labelling, spinning, bulk dispensing, plate reading, washing and incubating is demonstrated in an online video that shows ...
... _Blog of Mineral Processing (Metallurgy) Mineral Processing amp Extractive Metallurgy explained in simple practical terms engineers and operators can understand 2017713Mineral processing Wikipe
Introduction: The morphological and functional information provided by micro-CT and micro-PET allows monitoring of acute and chronic disease states in small laboratory animals. We examined in-vivo micro-CT and micro-PET as non-invasive tools to assess pulmonary fibrosis in mice.. Material/Methods: Pulmonary fibrosis was induced in mice by intratracheal delivery of an adenoviral gene vector encoding biologically active TGF-β1. Respiratory gated and ungated micro-CT was performed in 18 mice at 1 to 4 weeks after pulmonary adenoviral gene vector delivery. In 5 additional mice 18F-FDG micro-PET and micro-CT was performed. Imaging was correlated to histopathology and findings in animals exposed to a control vector. Radiation doses were measured using thermoluminescence dosimeters.. Results: Significant correlation between Ashcroft histology scoring and micro-CT was found for visual assessment scoring (p,0.001) and automated quantification by a region growing segmentation algorithm (p=0.004 for gated ...
A method was developed to estimate respiratory parameters of small laboratory animals. This method utilized a least squares estimation technique applied to a third order model of an animal respiring in a two chamber plethysmograph. The animal respiratory system was represented as generic second order model. This was followed by a fat order filter representing the thermal effects of respiration of
In small laboratory animals it may take only a few seconds before the distributional equilibrium of the drug between the plasma and the central compartment is achieved.glutamate, nitric oxide, TNF-a) released from astrocytes. Neurol Propecia calo del desiderio 1997; 19558в562. Challenges to the Management of NutrientвDrug Interactions Five challenges must be overcome rpopecia analyzing data to identify potential nutrientвdrug interactions 1.
... is fear-motivated tests classically used to assess short-term or long-term memory on small laboratory animals (rat, mice).
The saying in the design world is that form follows function. But in biology, and protein biology in particular, it would be more correct to say that form begets function. Shape and structure are the foundation for most protein-based interactions in cells, and are why basic functions like receptor binding, antibody neutralization and gene transcription work.. Two enzymes in the immune systems B cells, called RAG1 and RAG2, are a perfect example. Together, they form a complex that splices antibody-producing genes together in unique combinations through a process called V(D)J recombination. They do a similar job in T cells to build antigen-binding T-cell receptors (TCRs). In either case, the enzymes are essential to a robust immune response.. In a recent Cell paper, a team led by Hao Wu, PhD, of the Program in Cellular and Molecular Medicine (PCMM) at Boston Childrens Hospital and Maofu Liao, PhD, at Harvard Medical School used electronic microscopy to reveal how RAG1 and 2 interact at a ...
High-throughput genomic technologies continue to move in a direction where data yield from the instruments is increasing, while the cost for acquiring the technology is continuously decreasing. For example, the introduction of benchtop genome sequencers such as MiSeq from Illumina [1], has made complete sequencing of viral, bacterial, and small fungal genomes affordable to small laboratories. Nonetheless, acquiring the sequence is only the first step, and must be followed by large-scale computational analysis to process the data, test hypotheses and draw scientific insights. Therefore, investment in a sequencing instrument would normally be accompanied by substantial investment in computer hardware, skilled informatics support, and bioinformaticians competent in configuring and using specific software to analyze the data.. An alternative model is now available: computational capacity can be purchased as a service from a cloud computing provider, and specialized computational systems can be run ...
Butyrophenone is a chemical compound; some of its derivatives (called commonly butyrophenones) are used to treat various psychiatric disorders such as schizophrenia, as well as acting as antiemetics. Examples of butyrophenones include: Haloperidol, the most widely used classical antipsychotic drug in this class Benperidol, the most potent commonly used antipsychotic ( 200 times more potent than chlorpromazine ...
Antipsychotic drugs come in many different and confusing names. These include Acepromazine (Plegicil), Amisulpride (Solian), Amoxapine (Asendin), Aripiprazole (Abilify), Asenapine (Saphris, Sycrest), Benperidol (Anguil, Benguil, Frenactil, Glianimon), Blonanserin (Lonasen), Bromperidol (Bromodol, Impromen), Carpipramine (Defekton, Prazinil), Clocapramine (Clofekton, Padrasen), Chlorpromazine (Largactil, Thorazine), Chlorprothixene (Cloxan, Taractan, Truxal), Clopenthixol (Sordinol), Clotiapine (Entumine, Etomine, Etumine), Clozapine (Clozaril), (Haldol), Cyamemazine (Tercian), Dixyrazine (Esucos), Droperidol (Droleptan, Inapsine), Fluphenazine (Modecate, Permitil, Prolixin), Flupentixol (Depixol, Fluanxol), Fluspirilene (Imap), Haloperidol (Haldol, Serenace), Haloperidol (Haldol, Serenace), Iloperidone (Fanapt, Fanapta, Zomaril), Levomepromazine (Levinan, Levoprome, Nozinan), Loxapine (Adasuve, Loxitane), Lurasidone (Latuda), Mesoridazine (Lidanil, Serentil), Melperone (Buronil, Buronon, ...
Substances: Actinomycin-D; Alprazolam; Amitriptyline; Amobarbital; Aspirin; Atenolol; Barbital; Barbituric acid; Benperidol; Bethanidine sulfate; Bromazepam; Caffeine; Camptothecin; Captopril; Carbamazepine; Ciprofloxacin; Clindamycin; Clofibric acid; Clomipramine; Cocaine; Colchicine; Colchicoside; Diazepam; Diclofenac; Difloxacin; Dopa; Dopamine; Doxycycline; Ecgonine; Enrofloxacin; Erythromycin; Fenofibric acid; Flunitrazepam; Flurazepam; Hydrocortisone; Ibuprofen; Iohexol; Isomethadon hydrochloride; Isosorbide mononitrate; Ketoprofen, Lornoxicam; Meconic acid; Mephenesin; Methadon hydrochloride, Metharbital; Metoprolol; Naproxen; Nebivolol; Niclosamide; Nicotine, Nitrazepam; Norepinephrine; Norfloxacin; Nystatin; Opianic acid; Ormetoprim; Oxytetracycline; Papaverine; Paracetamol; Pefloxacin; Penicillin-G; Phenacetin; Phenobarbital; Prazepam; Propranolol; Pyridoxine; Sarafloxacin; Sotalol; Sulfacetamide; Sulfachloropyridazine; Sulfadiazine; Sulfadimethoxine; Sulfamerazine; Sulfamethazine; ...
TY - JOUR. T1 - Anesthesia protocols in laboratory animals used for scientific purposes. AU - Lo Monte, Attilio Ignazio. AU - Palumbo, Vincenzo Davide. AU - Cassata, Giovanni. AU - Fazzotta, Salvatore. AU - Cicero, Luca. AU - Cassata, Giovanni. AU - Cicero, Luca. PY - 2018. Y1 - 2018. N2 - Background: A suitable, effective and free of complications anesthetic protocol is very important in experimental studies on animal models since it could bias the outcome of a trial. To date there is no universally accepted protocol for induction, maintenance and recovery from anesthesia. The endotracheal intubation with the use of inhalation anesthesia is used very especially in the from of large size laboratory animals, because it is a secure and easy control mode. However, it is not common for small laboratory animals because of the high technical skills required. Aim: The aim of this paper is a review of the main methods of induction of anesthesia in laboratory animals. Materials and methods: We performed ...
1.1 This practice covers a short-term testing method to screen the subcutaneous tissue reaction to metallic or other implant candidate materials in small laboratory animals. The material may be dense or porous. The tissue reactions will be evaluated in comparison to those evoked by control materials that are accepted as clinical implant materials. ...
DNA vaccines have progressed rapidly from the conceptual stage to the stage of clinical trials. While studies in small laboratory animals have shown great promise, initial reports from human studies were less encouraging. Progress is being made, however, documented by the papers presented here. This volume contains the proceedings of a meeting devoted to the latest developments in DNA vaccines, from laboratory studies to clinical trials. The papers, written by leaders in the field, focus on the current state of DNA vaccines in humans and other large animals. The bulk of the studies involve DNA vaccines against HIV/SIV. Other promising trials make use of DNA vaccines against malaria and hepatitis B. The papers inform the reader about the immune basis of this form of vaccination and about approaches being developed to increase the efficacy of DNA vaccines in humans. These include the co-administration of cytokines, prime-boost strategies, optimising codon usage or the use of CpG motifs. An ...
DESCRIPTION (provided by applicant): Soft x-ray microscopy shows enormous promise as a technique for imaging cellular structures at resolutions well beyond what can be achieved in optical microscopes, and with much simpler sample preparation than is required for electron microscopy. In addition, the lower radiation dose required (compared to electron microscopy) allows tomographic investigation of subcellular structures in three dimensions. Existing synchrotron based microscopes have shown the potential of the soft x-ray microscope as a research tool, but they have the disadvantage of being tied to a massive light source at only a few national laboratories. A suitably bright, compact, low cost light source is the enabling innovation needed to realize a commercial biological soft x-ray microscope. In a Phase I NIH SBIR program (2R44RR022488-02) Energetiq demonstrated a unique, compact light source that generates the required x-ray wavelength and intensity for imaging. In the following Phase II ...
What do these societies have in common: Gotham City before Batman, the Star Wars universe under Emperor Palpatine, the wizarding world of Harry Potter, and the United States under George W. Bush? The citizens of these societies experienced learned helplessness. Whats learned helplessness? It is the type of "giving up" that happens to people when they are repeatedly or chronically in an aversive situation and nothing they do can stop or help them escape from it. The original research on learned helplessness, by psychologists Bruce Overmeier and Martin Seligman, went like this: A dog was placed in a cage, and received shocks from which it could not escape. After an initial response of agitation and making noises, the dog eventually became passive in response to the shocks-as if it gave up. The dog was then put in a new cage-with two halves that had a low barrier between the halves. If the dog jumped over the barrier when shocked, it could escape the shock. But the dog never did go over the ...
What do these societies have in common: Gotham City before Batman, the Star Wars universe under Emperor Palpatine, the wizarding world of Harry Potter, and the United States under George W. Bush? The citizens of these societies experienced learned helplessness. Whats learned helplessness? It is the type of "giving up" that happens to people when they are repeatedly or chronically in an aversive situation and nothing they do can stop or help them escape from it. The original research on learned helplessness, by psychologists Bruce Overmeier and Martin Seligman, went like this: A dog was placed in a cage, and received shocks from which it could not escape. After an initial response of agitation and making noises, the dog eventually became passive in response to the shocks-as if it gave up. The dog was then put in a new cage-with two halves that had a low barrier between the halves. If the dog jumped over the barrier when shocked, it could escape the shock. But the dog never did go over the ...
In mid-September - it had been a moody, rain-drenched month, as I recall - I admitted a 52-year-old man to the unit. Ill call him by the first letter of his given name, M. As medical interns, we were forewarned by the senior residents not to identify too closely with patients. "A weeping doctor is a useless doctor," a senior once told me. Or: "You cannot do an eye exam if your own eyes are clouded." But M.s case made it particularly hard. He was a doctor and a scientist - an M.D., a Ph.D., like me. He must have been about 15 years ahead of me in his schooling; I could imagine him returning to my class in med school to teach us "Patient-Doctor," in which students are taught how to deal with real-life patients. Hed trained as a medical resident and then as a fellow in cardiology at another hospital across town. He was now an assistant professor - it seemed like such a victory to have that title - and ran a small laboratory. I knew a student who once worked with him. Six degrees of separation? ...
To use a biotechnology means: used other living beings for the benefit of the human being. It has always been part of our evolution, and has many benefits. Today we will indicate one of them, the observation of animal diseases, lets you know how to cure them, research and work done by microbiologists managed to find ways to protect animals, is how small laboratories are born that apply biotechnology and develop biologics for this purpose, without having much knowledge of immunological principles.. Biotechnology, therefore, is a tool used against diseases; like vaccines improved with more knowledge, microbiological and immunological, are biologicals improved in their antigenicity and protection. Its use is one of the most cost-effective forms of prevention, control, food safety and public health. Although there are several types of vaccines, we can mention that most are composed of viruses or bacteria; these in turn are composed of live attenuated vaccines, killed or inactivated, with subunits, ...
The Hematology division of HORIBA Medical is providing a large range of hematology analyzers and automated instruments to realize blood analysis (blood cells identification and counting). These analysis will participate to the diagnosis of various blood related diseases. Our instruments are designed for all kind of laboratory, small laboratory (to 150 patients a day), to larger ones (more than 2000 patients a day). Indeed, efficient and reliable instruments, automated racks, data management and quality tools are providing the whole environment for high quality medical analysis requirements.. ...
Filmmaker and documentarian Werner Herzog (Aguirre the Wrath of God, Grizzly Man) continues his fascination with the current state of the planet Earth and its inhabitants with Lo and Behold, Reveries of the Connected World, which seeks to show how the internet has changed the way human beings live and perceive one another, with advancements in technology that has been of great benefit to us all, while at the same time been a source of pain and angst for many others. Directing and narrating the piece, Herzog offers these reveries, these daydreams and musings, in bite-sized vignettes, starting with the origin of the internet in a small laboratory on the UCLA campus in 1969 (the first transmission, meant to transmit the word L-O-G to another computer at Stanford University but crashed after the first two letters, forms the inspiration of the films title), all the way to the possible future in potential settlements in space beyond Earth.. Herzog globe-hops around the world to interview a wide ...
Methods of simulating biochemical/biophysical experiments will be explored using small laboratory computers. FORTRAN 77 is used to write computer programs relevant to their individual research. These computer programs will include, but not be limited to, the application of nonlinear least-squares and maximum likelihood parameter estimation procedures for the analysis of biophysical laboratory data. BIOP 801 - (1) (S ...
Dr Ellen Jo Baron, Emeritus Professor of Pathology at the Stanford University Medical Center and associated with Cepheid, gave the example of Cepheids Xpert HIV1 Viral Load assay which is strictly not a point-of-care test. But it can be done in a small laboratory that has necessary resources. It is fully automated, can identify all the sub-types and gives results in 90 minutes. Dr Baron shared that Cepheid has got a grant to create a finger-stick test for viral load testing, which is battery operated, portable, rugged, relatively affordable, can be run on omni instrument at remote sites. It is hoped to give results in less than 60 minutes, with an accuracy of 500 copies/ml ...
Dr Ellen Jo Baron, Emeritus Professor of Pathology at the Stanford University Medical Center and associated with Cepheid, gave the example of Cepheids Xpert HIV1 Viral Load assay which is strictly not a point-of-care test. But it can be done in a small laboratory that has necessary resources. It is fully automated, can identify all the sub-types and gives results in 90 minutes. Dr Baron shared that Cepheid has got a grant to create a finger-stick test for viral load testing, which is battery operated, portable, rugged, relatively affordable, can be run on omni instrument at remote sites. It is hoped to give results in less than 60 minutes, with an accuracy of 500 copies/ml ...
Activation of dopaminergic D2/D3 receptors modulates dorsoventral connectivity in the hippocampus and reverses the impairment of working memory following nerve ...
NMR imaging techniques have been applied to investigate complex fluid dynamics in pipes and in annular flow conditions. In this application, aimed to simulate drilling and production operations, two lines have been set up to reproduce, at small laboratory scale, respectively, a pipe flow and an annular flow that are typical flow geometries in oilfield wells during drilling. NMR imaging measurements have been performed inside a horizontal-bore magnet with a fluid flow assured in a velocity range of 10-100 cm s−1. The studies were dedicated to investigate the different flow regimes associated to circulating viscous polymer solutions applied in drilling mud formulations. Early transitions from laminar to turbulent regime were observed at very low Reynolds number (in a range between 300 and 500, to be compared with the theoretical transition value greater than 2100). © 2010 American Institute of Chemical Engineers AIChE J, 2011 ...
Tucked inside a small laboratory at UConns Technology Incubation Program (TIP) in Farmington, Conn., Nicole Wagner is trying to cure vision impairment and blindness for more than 30 million people worldwide.. Using a protein, grown in the laboratory and implanted behind the retina, this promising new procedure offers hope for patients with age-related macular degeneration (AMD) and other retinal diseases.. "These are terrible diseases that truly impact the quality of life for many people, said Wagner, the president and CEO of LambdaVision. "To offer patients the possibility of restoring their vision provides them the chance to see a new grandchild, resume a golf game, drive again or read a favorite book. For many people, restored vision would allow them to return to an independent life.. LambdaVision uses a light-activated protein, bacteriorhodopsin, to stimulate the retina of patients suffering from impaired or lost vision due to retinal degenerative diseases. The protein, isolated from ...
The LAMBDA MINIFOR bench-top autoclavable laboratory fermenter and bioreactor was developed as a result of the need to construct a small laboratory fermentor for volumes from 35 ml to over 6 liters. Based on long personal practical experience of fermentations, a fermentor-bioreactor which is easy to use and with the capacity to measure and control all the important parameters of the biological culture, has been created. This required new ideas and many innovations. The fermentor had to take up minimum space on the bench but with good access to all parts. Several fermentors should when placed side by side be suitable for the optimization of the parameters of growth of culture or optimization of bio-transformations etc. (highly suitable for parallel running experiments).. Each fermentor should be able to work independently or be connected to a PC for advanced regulation and extensive data treatment.. ...
CAS NO:20306-75-6; Chemical name:N-Methyl acetoacetylamide ; physical and chemical property of 20306-75-6, N-Methyl acetoacetylamide is provided by ChemNet.com
Vital Images had Q1 revenue 2007 of $20.8 million, a 32 percentincrease over $15.8 million of revenue a year ago. Net income for thefirst quarter increased to $2.4 million. This compares to net incomefor Q1 2006 of $1.4 million.
This booklet is a brand new variation of a truly renowned laboratory guide released via WHO within the Nineteen Eighties. the recent variation is important due to new tactics and applied sciences built because the past variation that experience proved worthwhile to small laboratories in constructing international locations. those new methods and applied sciences were incorporated within the proper sections of the guide, and a few out of date approaches were changed by means of extra updated techniques.. The guide presents a realistic advisor to the secure and actual functionality of easy laboratory options. meant to be used through laboratory technicians operating in peripheral-level laboratories in constructing international locations, the e-book emphasizes uncomplicated, low-budget methods which may yield actual effects the place assets, together with apparatus, are scarce and the weather is scorching and humid.. The e-book is split into 3 components. the 1st describes the setting-up of a ...
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TABLE-US-00002 TABLE 1 Y2R Y2R Y1R Y4R Y5R EC50 EC50 EC50 EC50 EC50 (nM) (nM) (nM) (nM) (nM) Exaple Sequence FLIRR cAMP FLIPR FLIPR FLIPR 1 Fmoc-linker-BHA-Resin 2 ABI-protocol 3 IKPEAPGEDASPEELNRYYASLRHY 0.013 0.038 356 1187 121 LNLVTRQRY (PYY 3-36) 4 Ac-IK-Pqa-RHYLNWVTRQ(N- 0.21 0.34 ,5000 ,5000 ,5000 methyl)RY 5 Ac-IK(Butyryl)-Pqa- 0.18 0.39 ,5000 31633 24896 RHYLNWVTRQ(N-methyl)RY 6 Ac-IK(Capryloyl)-Pqa- 1.45 1.7 5200 2467 99894 RHYLNWVTRQ(N-methyl)RY 7 Ac-IK(Lauroyl)-Pqa- 4.7 5.4 6433 14467 12845 RHYLNWVTRQ(N-methyl)RY 8 Protected Peptide Resin 9 IK(Lauroyl-6Ahx)-Pqa- 0.031 3.5 ,5000 2449 3793 RHYLNWVTRQ(N-methyl)RY 10 IK(Lauroyl-heta-Ala)-Pqa- 0.016 5.2 ,5000 3507 4743 RHYLNWVTRQ(N-methyl)RY 11 IK(Lauroyl-Glu)-Pqa- 0.026 3.6 ,5000 2427 3554 RHYLNWVTRQ(N-methyl)RY 12 IK(Myrisoyl-6Ahx)-Pqa- 0.14 0.16 ,5000 ,5000 1422 RHYLNWVTRQ(N-methyl)RY 13 Ac-IK(Palmitoyl)-Pqa- 1.31 1.2 29233 32167 9379 RHYLNWVTRQ(N-methyl)RY 14 IK(Palmitoyl)-Pqa- 0.73 1 ,5000 ,5000 12666 RHYLNWVTRQ(N-methyl)RY 15 ...
... This part of the eMedTV library takes an in-depth look at this question and highlights some important warnings and precautions with 5-hydroxytryptophan. This page also explains why many doctors do not recommend the product.
Harmon, L.J., Losos, J.B., Davies, T.J., Gillespie, R.G., Gittleman, J.L., Jennings, W.B. et al. (2010) Early bursts of body size and shape evolution are rare in comparative data. Evolution, 64, 2385-2396 ...
FZ is a bistriazole antifungal agent that distributes widely in body tissues (9) and which has been shown to have few side effects coupled with good therapeutic activity. The increased use of this drug has given rise to the development of resistance amongCandida spp.; as a result, it is important to monitor susceptibility. Since the NCCLS has a reference method and tentative breakpoints for three antifungal agents, results in the literature can be compared and any increase in the range of MICs can be detected. Performance of susceptibility tests by the NCCLS method on a large scale is difficult, but the agar diffusion test is easier for small laboratories. We have evaluated the ability of the agar diffusion method to separate strains that are susceptible and resistant to FZ with disks containing 15 μg of FZ. Previously, other investigators have evaluated a FZ diffusion test, but they used disks containing 25 μg (2, 15). Furthermore, the method described by Rodriguez-Tudela (18) was also ...
Physician office lab (POL) term is wide and diverse, it encompasses physicians practices as small (2 to 5 doctors) to large practitioners (200 physicians) that operate labs similar to small laboratory hospitals. Hospitals and commercial labs perform tests, but physicians prefer to perform in-house testing in order to enhance the patient care. In-house testing facilitates physicians to no longer rely on the reference labs for test results. In addition, physicians can obtain faster results from their own labs and increase profits. POL also reduces the chances of loss or deterioration of the sample. Therefore, definition of POL is broad and it refers to the test performed in: physician office setting, provides a result during medical visit, conducted at the time of consultation or with other healthcare professional and is used for diagnosis, screening or monitoring purposes ...
PURPOSE: To review the current status and possible future of neuroleptanalgesia/anesthesia, techniques that may be nearly extinct. SOURCE: Articles from 1966 to present were obtained from the Current Science and Medline databases. Search terms include neurolepananalgesia/anesthesia, conscious sedation, droperidol, benzodiazepines, propofol, ketamine, and opioids. Information and abstracts obtained from meetings on this topic helped complete the collection of information. PRINCIPAL FINDINGS: Droperidol/fentanyl may still be clinically indicated in the management of surgical seizure therapy for electrocorticography. However, the high incidence of post-operative sedation and restlessness discourage its use for other surgical or diagnostic procedures. Many surgical interventions, once thought ideally suited for neuroleptic agents, now meet better success with newer medications. The use of midazolam and/or propofol, in association with newer opioids, provides ideal anesthetic combinations. ...
Bojarski, A. J.; Paluchowska, M. H.; Duszyńska, B.; Kłodzińska, A.; Tatarczyńska, E.; Chojnacka-Wójcik, E. 1-Aryl-4-(4-succinimidobutyl)piperazines and their conformationally constrained analogues: synthesis, binding to serotonin (5-HT1A, 5-HT2A, 5-HT7), α1-adrenergic and dopaminergic D2 receptors, and in vivo 5-HT1A functional characteristics. Bioorg. Med. Chem. 2005, 13, 2293-3303 (http://www.ncbi.nlm.nih.gov/pubmed/15727878 ...
The variations of plasmatic beta-endorphin and cortisol levels are studied in 3 groups of patients. These subjects are submitted to abdominal surgery following 3 different anaesthetic schemes: neuroleptanalgesia (droperidol and fentanyl), pure analgesia (fentanyl), association halothane - small dose of fentanyl. The study covers the period from premedication through recovery. The results of this work demonstrates that the average level of beta-endorphin in neuroleptanalgesia and pure analgesia series is stable; there is an increase in the halothane series just after the incision until waking up. The average level of cortisol is stable for the 3 series until incision. It is strongly increased in the neuroleptanalgesia series and in the halothane series. This increase is delayed and reduced in the fentanyl series.
Rheumatic fever causes chronic progressive damage to the heart and its valves and is the most common cause of pediatric heart disease in the world. Until 1960, it was a leading cause of death in children and a common cause of structural heart disease.
article{Schneider-walker1997, author = "T. D. Schneider", title = "Sequence Walkers: a graphical method to display how binding proteins interact with {DNA} or {RNA} sequences", journal = "Nucleic Acids Res.", volume = "25", note = "\htmladdnormallink {https://doi.org/10.1093/nar/25.21.4408} {https://doi.org/10.1093/nar/25.21.4408}, \htmladdnormallink {http://alum.mit.edu/www/toms/papers/walker/} {http://alum.mit.edu/www/toms/papers/walker/}, erratum: NAR 26(4): 1135, 1998", pages = "4408--4415", pmid = "9336476", pmcid = "PMC147041", year = "1997 ...
A label is provided, comprising a means wherein penetrating radiation leaves a human- or machine-readable semi-permanent or permanent mark. Preferably said means is a storage phosphor. A method for using such a label for checking if an articles has been inspected by penetrating radiation and a method for using such a label as personal monitoring are also provided.
Dear colleagues: Could someone tell me which is the best protein expression system or successful experience to use pET system because i always have trouble to use pET protein expresion system(Novagen).Thank you very much. __________________________________________________ Do You Yahoo!? Get personalized email addresses from Yahoo! Mail - only $35 a year! http://personal.mail.yahoo.com/ ...
significant amounts of coinsurance are not collectable today and that collection costs can range from $12.00-$18.00 a claim when considering the cost to produce the bill and duplicate bills, provide postage, track the bills, and utilize a collection agency for uncollected payments. The cost of collection is staggering when considering that coinsurance on Medicare Part B laboratory services will require laboratories to generate at least 200 million bills annually to beneficiaries.. The cost to our health care system of collecting the laboratory coinsurance far exceeds any savings members of Congress or the Administration believes can be achieved and places the burden of this cost largely on Americas laboratories. At the very least, an adjustment to the Medicare laboratory fee schedule to sustain this increased cost for doing business would be necessary, further increasing health care spending. Otherwise, this situation would be intolerable, particularly for small laboratory businesses, causing ...
Definition of N-acetyl-6-hydroxytryptophan oxidase with photos and pictures, translations, sample usage, and additional links for more information.
For the last few years we have been trying to show the advantages of a simplified treatment of ionic equilibria in which we underscore the commonalities among acid base, oxidation reduction, precipitation, and complexation reactions and also to improve it. In the proposed treatment, the above reactions are seen as the result of a particle exchange between a donor and an acceptor that belong to two different conjugate pairs. This treatment also proposes a graphical method for solving equilibrium problems through the use of predominance diagrams. Though most introductory chemistry courses present ionic equilibria separately, it is of interest pedagogically to generalize and study them jointly as this provides coherence and systematization as well as a global vision of ionic reactions. In this article, the unified treatment is applied to oxidation reduction equilibria and to the resolution of redox problems. The paper also includes a comparison between the proposed treatment and the traditional ...
Novel phosphor systems for a white LED are disclosed. The phosphor systems are excited by a non-visible to near-UV radiation source having an excitation wavelength ranging from about 250 to 420 nm. The phosphor system may comprise one phosphor, two phosphors, and may include optionally a third and even a fourth phosphor. In one embodiment of the present invention, the phosphor is a two phosphor system having a blue phosphor and a yellow phosphor, wherein the long wavelength end of the blue phosphor is substantially the same wavelength as the short wavelength end of the yellow phosphor. Alternatively, there may be a wavelength gap between the yellow and blue phosphors. The yellow phosphor may be phosphate or silicate-based, and the blue phosphor may be silicate or aluminate-based. Single phosphor systems excited by non-visible radiation are also disclosed. In other embodiments of present invention, a single phosphor is used to produce white light illumination, the single phosphor having a broad
Introduction: Butyrophenone drugs including haloperidol are being widely used in the field of psychiatry. The acute butyrophenone poisoning incidents sometimes take place; in such cases, the analysis of a butyrophenone becomes necessary in forensic toxicology or clinical toxicology. Their analysis is being made by GC [1-4], GC/MS [5-6], HPLC [7-15] and LC/MS [16,17]. Six butyrophenones are now available as ethical drugs in Japan ( Fig. 2.1); the most typical ones are haloperidol and bromperidol, which most frequently cause poisoning incidents among butyrophenones. ...
A phosphor tape article includes a phosphor layer having a phosphor and a polymeric binder material, a pressure sensitive adhesive layer disposed adjacent the phosphor layer such that light transmitted through the pressure sensitive adhesive layer is received by the phosphor layer, and a release liner disposed on the pressure sensitive adhesive layer. The pressure sensitive adhesive layer is disposed between the release liner and the phosphor layer. The phosphor is suitable for excitation by UV or blue LED light, and the phosphor emission has a characteristic decay rate of less than 1 second. Light emitting devices including pieces of phosphor tape, and methods of making such devices, are also disclosed.
The report generally describes n-methyl piperazine(nmp), examines its uses, production methods, patents. N-Methyl piperazine(NMP) market situation is
Haloperidol is a typical butyrophenone type antipsychotic that exhibits high affinity dopamine D 2 receptor antagonism and slow receptor dissociation kinetics. [42] It has effects similar to the phenothiazines . [17] The drug binds
Product Name: 5-Hydroxytryptophan Alias: 5-HTP CAS: 56-69-9; 4350-09-8 EINECS: 200-284-8 MF: C11H12N2O3 MW: 220.22 Purity: 98% MP: 298-300°C Density: 1.484g/cm3 Grade: Pharmaceutical Grade Appearance: White Powder Description 5-Hydroxytryptophan (5-HTP) is a supplement that some people use in an eff Health, Beauty & Fitness , Chandigarh, Chandigarh 201386
Drawn from the second edition of the best-selling Phosphor Handbook, Practical Applications of Phosphors outlines methods for the production of various phosphors and discusses a broad spectrum of applications. Beginning with methods for synthesis and…
Learn more about 5-Hydroxytryptophan at LewisGale Regional Health System Supplement Forms/Alternate Names 5-HTP Uses Principal Proposed Uses ...
Looking for online definition of N-methyl D-aspartate receptor subtype 2C in the Medical Dictionary? N-methyl D-aspartate receptor subtype 2C explanation free. What is N-methyl D-aspartate receptor subtype 2C? Meaning of N-methyl D-aspartate receptor subtype 2C medical term. What does N-methyl D-aspartate receptor subtype 2C mean?
(Sr, Ca, Ba)Al2O4:Eu2+, Dy3+ phosphors were prepared via a high temperature solid-state reaction method. The correlation of phase structure, optical properties and lifetimes of the phosphors are investigated in this work. For the (Sr, Ca)Al2O4:Eu2+,Dy3+ phosphors, the different phase formation from monoclinic SrAl2O4 phase to hexagonal SrAl2O4 phase to monoclinic CaAl2O4 phase was observed when the Ca content increased. The emission color of SrAl2O4:Eu2+, Dy3+ phosphors varied from green to blue. For the (Sr, Ba)Al2O4:Eu2+, Dy3+ phosphors, different phase formation from the monoclinic SrAl2O4 phase to the hexagonal BaAl2O4 phase was observed, along with a shift of emission wavelength from 520 nm to 500 nm. More interestingly, the decay time of SrAl2O4:Eu2+, Dy3+changed due to the different phase formations. Lifetime can be dramatically shortened by the substitution of Sr2+ with Ba2+ cations, resulting in improving the performance of the alternating current light emitting diode (AC-LED). Finally, intense
An apparatus, comprises an active region, a phosphor layer and a reflective layer. The active region is configured to emit light having a first band of wavelengths from a first group of wavelengths. The phosphor layer is disposed between and in contact with the active region and an exterior medium. The phosphor layer is configured to convert the first band of wavelengths of light emitted from the active region to a second band of wavelengths. A center wavelength of the second band of wavelengths is greater than a center wavelength of the first band of wavelengths. The reflective layer is optically coupled to the active region. The active region is disposed between the reflective layer and the phosphor layer. The reflective layer is configured to reflect at least the first band of wavelengths and the second band of wavelengths.
Haloperidol, a neuroleptic agent with potent antidopaminergic properties, is still considered the drug of choice for the treatment of delirium in the patient with cancer; [1] [7] however, the evidence remains limited. A double-blind trial of haloperidol, chlorpromazine, and lorazepam in the treatment of hospitalized patients with delirium and acquired immunodeficiency syndrome suggested that haloperidol and chlorpromazine were equivalent in efficacy, and both were associated with a low prevalence of EPS. Lorazepam, however, was ineffective and associated with adverse effects, resulting in early closure of this arm of the protocol. [18][Level of evidence: I] The optimal dose range of haloperidol for patients with delirium has not been determined. Consensus guidelines recommended initial doses in the range of 1 to 2 mg every 2 to 4 hours as needed and lower starting doses, such as 0.5 mg every 4 hours as needed, in elderly patients. [7]. Haloperidol can be administered orally, intravenously, ...
Haloperidol, a neuroleptic agent with potent antidopaminergic properties, is still considered the drug of choice for the treatment of delirium in the patient with cancer; [1] [7] however, the evidence remains limited. A double-blind trial of haloperidol, chlorpromazine, and lorazepam in the treatment of hospitalized patients with delirium and acquired immunodeficiency syndrome suggested that haloperidol and chlorpromazine were equivalent in efficacy, and both were associated with a low prevalence of EPS. Lorazepam, however, was ineffective and associated with adverse effects, resulting in early closure of this arm of the protocol. [18][Level of evidence: I] The optimal dose range of haloperidol for patients with delirium has not been determined. Consensus guidelines recommended initial doses in the range of 1 to 2 mg every 2 to 4 hours as needed and lower starting doses, such as 0.5 mg every 4 hours as needed, in elderly patients. [7]. Haloperidol can be administered orally, intravenously, ...
[150 Pages Report] Check for Discount on 2016 Global and Chinese 2-Aminophenol-4-(N-Methyl)Sulfonamide (CAS 85237-56-5) Industry Market Research Report report by Prof Research. The Global and Chinese 2-Aminophenol-4-(N-Methyl)Sulfonamide...
Water, Quality, Water testing, Biological analysis and testing, Organic chemistry, Biodegradability, Aerobic bacteria, Test duration, Testing conditions, Carbon, Determination of content, Biochemical methods of analysis, Toxic materials, Graphical methods ...
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...

Benperidol for schizophrenia | CochraneBenperidol for schizophrenia | Cochrane

Benperidol for schizophrenia. Benperidol is a relatively old drug that is used for the treatment of schizophrenia in several ... Benperidol is a relatively old antipsychotic drug that has been marketed since 1966. It has been used in Germany for 30 years ... Although benperidol was first marketed in 1966, more trials on this drug are justified as with the advent of new compounds ... Benperidol is a butyrophenone antipsychotic, with the highest neuroleptic potency in terms of D2 receptor blockade. Those ...
more infohttp://www.cochrane.org/CD003083/SCHIZ_benperidol-for-schizophrenia

Benperidol - WikipediaBenperidol - Wikipedia

Benperidol is a drug which is a highly potent butyrophenone derivative. It is the most potent neuroleptic on the European ... Benperidol was discovered at Janssen Pharmaceutica in 1961. Timiperone has the same structure but thiourea instead of normal ... Möller; Müller; Bandelow: Neuroleptika, 2001, WVG; ISBN 3-8047-1773-X (in German) Bobon J, Collard J, Lecoq R, Benperidol and ...
more infohttps://en.wikipedia.org/wiki/Benperidol

benperidol | Ligand page | IUPHAR/BPS Guide to PHARMACOLOGYbenperidol | Ligand page | IUPHAR/BPS Guide to PHARMACOLOGY

benperidol ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs. ...
more infohttp://www.guidetopharmacology.org/GRAC/LigandDisplayForward?tab=clinical&ligandId=9215

Butalbital-D5 (0.1 mg/ml) in Methanol- CAS Number 145243-96-5Butalbital-D5 (0.1 mg/ml) in Methanol- CAS Number 145243-96-5

Benperidol. 10 mg. LGCFOR0113.00. In den Warenkorb Benserazide Hydrochloride. 10 mg. LGCFOR1282.00. In den Warenkorb ...
more infohttps://www.lgcstandards.com/DE/de/Butalbital-D5-0-1-mg-ml-in-Methanol/p/CERB-005

Oxycodone And Aspirin (Oral Route) Before Using - Mayo ClinicOxycodone And Aspirin (Oral Route) Before Using - Mayo Clinic

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.. ...
more infohttps://www.mayoclinic.org/drugs-supplements/oxycodone-and-aspirin-oral-route/before-using/drg-20074140

Chlorpheniramine and codeine polistirex Advanced Patient Information - Drugs.comChlorpheniramine and codeine polistirex Advanced Patient Information - Drugs.com

Detailed drug Information for chlorpheniramine and codeine polistirex. Includes common brand names, drug descriptions, warnings, side effects and dosing information.
more infohttps://www.drugs.com/cons/chlorpheniramine-and-codeine-polistirex.html

Oxycodone and acetaminophen Advanced Patient Information - Drugs.comOxycodone and acetaminophen Advanced Patient Information - Drugs.com

Detailed drug Information for oxycodone and acetaminophen. Includes common brand names, drug descriptions, warnings, side effects and dosing information.
more infohttps://www.drugs.com/cons/oxycodone-and-acetaminophen.html

Phenothiazine (Oral Route, Parenteral Route, Rectal Route) Proper Use - Mayo ClinicPhenothiazine (Oral Route, Parenteral Route, Rectal Route) Proper Use - Mayo Clinic

Do not take this medicine within 2 hours of taking antacids or medicine for diarrhea. Taking these products too close together may make this medicine less effective.. This medicine will add to the effects of alcohol and other central nervous system (CNS) depressants (medicines that slow down the nervous system, possibly causing drowsiness). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are using this medicine.. Before using any prescription or over-the-counter (OTC) medicine for colds or allergies, check with your doctor. These medicines may increase the chance of developing heatstroke or other unwanted effects, such as dizziness, dry mouth, blurred vision, and constipation, while ...
more infohttps://www.mayoclinic.org/drugs-supplements/phenothiazine-oral-route-parenteral-route-rectal-route/proper-use/DRG-20070394?p=1

Molecules  | Free Full-Text | Current Concepts and Treatments of Schizophrenia | HTMLMolecules | Free Full-Text | Current Concepts and Treatments of Schizophrenia | HTML

Another group of typical antipsychotic drugs are butyrophenones (e.g., benperidol, droperidol, and haloperidol) whose ...
more infohttps://www.mdpi.com/1420-3049/23/8/2087/htm

Category:Piperidines - Wikimedia CommonsCategory:Piperidines - Wikimedia Commons

De tekst is beschikbaar onder de licentie Creative Commons Naamsvermelding-Gelijk delen. Er kunnen aanvullende voorwaarden van toepassing zijn. Zie de Gebruiksvoorwaarden voor meer informatie ...
more infohttps://commons.wikimedia.org/wiki/Category:Piperidines?uselang=nl

Pharmacovigilance in Gerontopsychiatric Patients - Full Text View - ClinicalTrials.govPharmacovigilance in Gerontopsychiatric Patients - Full Text View - ClinicalTrials.gov

Drug: Benperidol. Drug: Sertindole. Drug: Ziprasidone. Drug: Flupentixol. Drug: Chlorprothixene. Drug: Zuclopenthixol. Drug: ... Benperidol Drug: Sertindole Drug: Ziprasidone Drug: Flupentixol Drug: Chlorprothixene Drug: Zuclopenthixol Drug: Fluspirilene ...
more infohttps://clinicaltrials.gov/ct2/show/NCT02374567?cond=%22Somatoform+Disorder%22&rank=49

Side effects - Rethink Mental Illness, the mental health charitySide effects - Rethink Mental Illness, the mental health charity

Benperidol + +. +/-. +++. +. +. +++. Chlorpromazine +++. ++. ++. ++. ++ +++ +++. Clozapine +++. +++ +++. -. +++ +++. -. ...
more infohttps://www.rethink.org/diagnosis-treatment/medications/antipsychotics/side-effects

Haloperidol vs Olanzapine for the Management of ICU DeliriumHaloperidol vs Olanzapine for the Management of ICU Delirium

Benperidol. A butyrophenone with general properties similar to those of HALOPERIDOL. It has been used in the treatment of ...
more infohttps://www.bioportfolio.com/resources/trial/80449/Haloperidol-vs-Olanzapine-for-the-Management-of-ICU-Delirium.html

Plus itPlus it

The Kb values were (nanomolar):spiperone, 0.8; spirilene , 2.1; benperidol , 4.4; azaperone, 16.6; and haloperidol, 96.6. The ...
more infohttp://jpet.aspetjournals.org/content/229/2/346

ATC 코드 N05 - 위키백과, 우리 모두의 백과사전ATC 코드 N05 - 위키백과, 우리 모두의 백과사전

N05AD07 Benperidol. N05AD08 Droperidol. N05AD09 Fluanisone. QN05AD90 Azaperone. N05AE 인돌 계열[편집]. N05AE01 Oxypertine. N05AE02 ...
more infohttps://ko.wikipedia.org/wiki/ATC_%EC%BD%94%EB%93%9C_N05

Cinchocaine - DrugBankCinchocaine - DrugBank

Benperidol. The risk or severity of adverse effects can be increased when Cinchocaine is combined with Benperidol.. Approved, ...
more infohttps://www.drugbank.ca/drugs/DB00527

Enflurane - DrugBankEnflurane - DrugBank

Benperidol. The risk or severity of adverse effects can be increased when Enflurane is combined with Benperidol.. ...
more infohttps://www.drugbank.ca/drugs/DB00228

Janssen productsJanssen products

Benperidol. Antalgola. Benzalkonium Saccharinate; Cineole; Menthol; Pumilio Pine Oil. Antalgola Plus. Benzalkonium Saccharinate ...
more infohttp://drugs-about.com/firms/janssen.html

STP : main GiPCRsSTP : main GiPCRs

benperidol (Anquil ). * droperidol (Inapsine ). * fluspirilene (effective for 1 week). * haloperidol (decanoate) (Haldol , ...
more infohttp://www.ufrgs.br/imunovet/molecular_immunology/stpgipcrs.html

ATC code N05ATC code N05

N05AD07 Benperidol N05AD08 Droperidol N05AD09 Fluanisone N05AE Indole derivatives. N05AE01 Oxypertine N05AE02 Molindone N05AE03 ...
more infohttps://www.bionity.com/en/encyclopedia/ATC_code_N05.html

Morphine (Injection route)Morphine (Injection route)

It is very important that your doctor check the progress or you or your child while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to use it. This medicine will add to the effects of alcohol and other CNS depressants (medicines that can make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for allergies or colds; sedatives, tranquilizers, or sleeping medicine; other prescription pain medicine or narcotics; medicine for seizures or barbiturates; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before you or your child take any of the medicines listed above while you are using this medicine. This medicine may be habit-forming. If you or your child feel that the medicine is not working as well, do not use more than your prescribed dose. Call your doctor for instructions. Using narcotics for a long time can cause severe ...
more infohttps://www.allinahealth.org/CCS/doc/Thomson%20Detailed%20Drugs/47/603251.htm

Medikamentenspiegel - Labor LimbachMedikamentenspiegel - Labor Limbach

Benperidol. Neuroleptikum. Glianimon. LC MS MS. 0,5 (0,2) ml Serum/Plasma, tiefgefroren. 1-10 µg/L. tägl. Mo-Sa. ...
more infohttp://www.labor-limbach.de/Medikamentenspiegel.222.0.html?L=bimsplrqg

Buprenorphine - Uses, Side Effects, Interactions & Reviews - GoodRxBuprenorphine - Uses, Side Effects, Interactions & Reviews - GoodRx

Buprenorphine (Generic Butrans, Buprenex, Subutex) is used to treat Pain and Opioid Dependence. Learn about Buprenorphine uses before beginning treatment with Pharmacist Tips and User Reviews!
more infohttps://www.goodrx.com/buprenorphine/side-effects
  • Benperidol is a relatively old drug that is used for the treatment of schizophrenia in several European countries. (cochrane.org)
  • Although benperidol was first marketed in 1966, more trials on this drug are justified as with the advent of new compounds there is a danger that inexpensive drugs such as benperidol remain under-researched and overlooked. (cochrane.org)
  • We included all randomised controlled trials that compared benperidol with other treatments for people with schizophrenia, or schizophrenia-like psychoses. (cochrane.org)
  • A high-performance liquid chromatographic method for the quantitative determination of benperidol in human plasma using haloperidol as internal standard is described. (semanticscholar.org)