A vasodilator agent found to be effective in a variety of peripheral circulation disorders. It has various other potentially useful pharmacological effects. Its mechanism may involve block of calcium channels.

Slow channel inhibitor effects on brain function: tolerance to severe hypoxia in the rat. (1/2)

1. The protective effects of ten slow channel inhibitor drugs against severe progressive hypoxia were investigated in rats breathing spontaneously during light anaesthesia. Respiration, heart rate, electrocorticogram (ECoG) and/or electroencephalogram (EEG) were recorded. 2. Tolerance times were monitored from hypoxia onset until cessation of respiration, ECoG, EEG synchronization, and 'background-EEG'. Drugs were administered i.v. 5 min before the onset of hypoxia. 3. Verapamil, gallopamil, and nimodipine resulted in a significant increase of tolerance times; fendiline and bepridil showed a small increase (not significant); bencyclan and prenylamine were ineffective; cinnarizine and diltiazem slightly reduced tolerance times as did flunarizine at low doses. 4. At protective doses, verapamil, gallopamil, and nimodipine significantly raised the respiration rate but had little or no cardiac depressor effects. Bencyclan showed ventilatory drive but cardiocirculatory depression. A clear-cut ventilatory drive did not occur with the other ineffective slow channel inhibitors. 5. It is suggested that the protective actions observed were not due to slow channel inhibition per se, nor to spasmolytic potency or increased cerebral blood flow. Ventilatory drive associated with other cardiopulmonary actions which secondarily raise the brain oxygen supply are likely to be responsible for this effect.  (+info)

Comparative studies of cerebral vasodilators on relaxation activities in isolated basilar, mesenteric and pulmonary arteries of rabbits. (2/2)

Effects of cerebral vasodilators such as bencyclane, cinnarizine, and papaverine were comparatively studied using helically cut basilar and superior mesenteric arteries and radial muscle preparations of pulmonary arteries with the sympathetic nerve isolated from rabbits. The order of relaxation activities on high K+-induced contractures was cinnarizine>bencyclane>papaverine in basilar strips and cinnarizine>papaverine>bencyclane in mesenteric strips. Relaxation responses of basilar strips to cinnarizine and bencyclane were faster and more marked than those seen in mesenteric strips. Responses to papaverine were equipotent in both preparations. The action of cinnarizine alone was irreversible. In mesenteric strips, the order of the sensitivity of contractile responses to cumulatively applied biogenic amines was serotonin>noradrenaline>histamine. Cinnarizine produced an antihistaminergic action, while bencyclane produced an antiserotonergic action. In pulmonary arteries, 6 x 10(-6) g/ml papaverine inhibited contractile responses to 2, 5, and 25 Hz nerve stimulation in a frequency-independent manner together with inhibition of responses to noradrenaline. Bencyclane at 6 x 10(-6) and 10(-5) g/ml selectively inhibited in a dose-dependent manner contractile responses only to 25 Hz without inhibition of responses to noradrenaline. These results were discussed in comparison with findings of the cerebral vasodilators obtained using other experimental techniques. Spiral strips of basilar arteries from rabbits in combination with peripheral arteries may be used as a simple quantitative, and reproducible screening method in a preclinical stage for drug evaluation of cerebral vasodilators.  (+info)

Bencyclane is a muscle relaxant and antispasmodic medication. It is not a commonly used drug and may be difficult to find in many countries. It works by blocking the action of certain chemicals in the body that can cause smooth muscle spasms, which can lead to various symptoms such as abdominal pain or cramping, urinary frequency or urgency, and other related conditions.

Bencyclane is available in various forms, including tablets and suppositories, and is typically prescribed for short-term use due to its potential for side effects, which can include dizziness, drowsiness, dry mouth, and blurred vision. It should be used with caution and under the supervision of a healthcare provider, as it may interact with other medications and medical conditions.

It is important to note that while I strive to provide accurate and up-to-date information, this definition may not be completely comprehensive or current. Therefore, it is always best to consult with a healthcare professional for medical advice.

... is an antispasmodic, vasodilator, and platelet aggregation inhibitor. Grignard addition of benzylmagnesiumbromide to ... completed the synthesis of bencyclane (3). Clofenciclan J. Elks, ed. (2014). The Dictionary of Drugs: Chemical Data, Structures ...
... is a precursor to bencyclane, a spasmolytic agent and vasodilator. Pimelic acid is produced by the oxidative ...
C04AF01 Kallidinogenase C04AX01 Cyclandelate C04AX02 Phenoxybenzamine C04AX07 Vincamine C04AX10 Moxisylyte C04AX11 Bencyclane ...
... bencyclane MeSH D02.455.426.392.368.284.900 - tropolone MeSH D02.455.426.392.368.367 - cyclohexanes MeSH D02.455.426.392. ...
... bencyclane (INN) bendacalol (INN) bendamustine (INN) bendazac (INN) bendazol (INN) Bendectin benderizine (INN) Bendopa ...
Bencyclane is an antispasmodic, vasodilator, and platelet aggregation inhibitor. Grignard addition of benzylmagnesiumbromide to ... completed the synthesis of bencyclane (3). Clofenciclan J. Elks, ed. (2014). The Dictionary of Drugs: Chemical Data, Structures ...
Bencyclane - a new aspect of the mechanism of action in patients with peripheral arterial occlusive disease. Open-label, ...
Tolazamide is an oral blood glucose lowering drug used for people with Type 2 diabetes. It is part of the sulfonylurea family (ATC A10BB).
Bencyclane fumarate Galidor ® Bosentan * (Bosentanum). Bosenex ® Bosentan Bosentanski kanon Bosentan monohidrat Vazenex ...
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Bencyclane (10 microM) decreased the Vmax from 333.7 +/- 6.9 V/sec to 302.7 +/- 10.2 V/sec (n = 6, p less than 0.05) in ... In skeletal muscle bencyclane increased the time of 50% repolarization by 33.3 +/- 2.5% (n = 7, p less than 0.01) and decreased ... It was concluded that the antiarrhythmic action of bencyclane, based on the use-dependent blockade of sodium channels, might be ... Use-dependent blockade of sodium channels induced by bencyclane in frog skeletal muscle and canine cardiac Purkinje fiber / P. ...
Bencyclane. Iodochlorhydroxyquin. Retinal. Coniferin. ©2016 DrugLead US FDA&EMEA. ...
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There is some evidence that pentoxifylline can lower the levels of some biomarkers in non-alcoholic steatohepatitis but evidence is insufficient to determine if the drug is safe and effective for this use.[21] Animal studies have been conducted exploring the use of pentoxifylline for erectile dysfunction[22] and hearing loss.[23] Human studies have been conducted for Peyronies disease.[24] Pentoxifylline, in combination with tocopherol and clodronate, has been found to heal refractory osteoradionecrosis of the jaw,[25] and to be prophylactic against osteoradionecrosis.[26] In a Cochrane systematic review on the use of pentoxifylline for intermittent claudication in 2015, the following was concluded "The quality of included studies was generally low, and very large variability between studies was noted in reported findings including duration of trials, doses of pentoxifylline and distances participants could walk at the start of trials. Most included studies did not report on randomisation ...
Halidor use Bencyclane Halitoses use Halitosis Halitosis Hall Aqua Hall Hittner Syndrome use CHARGE Syndrome ...
Halidor use Bencyclane Halitoses use Halitosis Halitosis Hall Aqua Hall Hittner Syndrome use CHARGE Syndrome ...
Halidor use Bencyclane Halitoses use Halitosis Halitosis Hall Aqua Hall Hittner Syndrome use CHARGE Syndrome ...
Halidor use Bencyclane Halitoses use Halitosis Halitosis Hall Aqua Hall Hittner Syndrome use CHARGE Syndrome ...
"Bencyclane" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Bencyclane" by people in this website by year, and whether " ... Below are the most recent publications written about "Bencyclane" by people in Profiles. ...
Bencyclane Fumarate. Diven. Promethazine. Ferroper. Ferrous Gluconate. Fesanol. Naphazoline Nitrate; Pyrilamine Maleate. ...
Bencyclane,create,27-JUN-08,(null),(null) C74227,Sornidipine,create,27-JUN-08,(null),(null) C74228,Sabiporide,create,27-JUN-08 ... Bencyclane_Fumarate,modify,27-JUN-08,(null),(null) C73800,Tenidap_Sodium,modify,27-JUN-08,(null),(null) C73825,Sanfetrinem, ...
Bencyclane Fumarate Narrower Concept UI. M0002308. Registry Number. OZN2MG334O. Terms. Bencyclane Fumarate Preferred Term Term ... Bencyclane Preferred Concept UI. M0002307. Registry Number. 6I97Z6S135. Related Numbers. 2179-37-5. OZN2MG334O. Scope Note. A ... Bencyclane Preferred Term Term UI T004456. Date01/01/1999. LexicalTag NON. ThesaurusID ... Bencyclane Fumarate Desoblit Dilangio compositu Fludilat Fluxema Halidor Pharm Action. Calcium Channel Blockers. Vasodilator ...
Bencyclane Fumarate Narrower Concept UI. M0002308. Registry Number. OZN2MG334O. Terms. Bencyclane Fumarate Preferred Term Term ... Bencyclane Preferred Concept UI. M0002307. Registry Number. 6I97Z6S135. Related Numbers. 2179-37-5. OZN2MG334O. Scope Note. A ... Bencyclane Preferred Term Term UI T004456. Date01/01/1999. LexicalTag NON. ThesaurusID ... Bencyclane Fumarate Desoblit Dilangio compositu Fludilat Fluxema Halidor Pharm Action. Calcium Channel Blockers. Vasodilator ...
bencyclane. pentoxifilline. intermittent claudication. nitric oxide. total antioxidant status of the plasma. ... The objective of this study was a comparison of bencyclane versus pentoxifilline effects on the clinical picture (pain free ... The objective of this study was a comparison of bencyclane versus pentoxifilline effects on the clinical picture (pain free ... Conclusions. The administration of bencyclane and pentoxifilline is an effective therapeutic approach for patients with ...
Sénac subsequently became physician to Louis XV of France, a counselor of the state, and superintendent of the mineral waters and medicinals in France. As a result of his influence, throughout the 19th century, quinine was used to augment digitalis therapy. It was described as das Opium des Herzens (the opium of the heart). However, the use of quinidine to treat arrhythmia really only came into its own because a physician listened to the astute observation of one of his patients. In 1912, Karel Frederik Wenckebach saw a man with atrial fibrillation. He was a Dutch merchant, used to good order in his affairs. He would like to have good order in his heart business, also, and asked, "why there were heart specialists if they could not abolish this very disagreeable phenomenon ... he knew himself how to get rid of his attacks. As I did not believe him, he promised to come back next morning with a regular pulse, and he did." The man had found by chance that when he took one gram of quinine during an ...
... bencyclane fumarate, E0300540,Fludilat,bencyclane fumarate, E0300543,Acifugan,benzbromarone, E0300544,Desuric,benzbromarone, ...
... bencyclane, ichthyosauroid beyond caseworker. Aboard www.ngmdevelopment.nl who kopen geneeskunde xtandi apeldoorn dupla a ...
Can everyday walking replace treadmill training in patients with claudication? Do Bencyclane fumarate or Xanthinol nicotinate ...
Thruout meltons invent scarce clausal including Karlsbad, bencyclane during earmark this oculomoter times enjoys. ...
Mohri, Z.; Yasuda, T.; Kawahara, K.; Shono, F.; Yoshitake, A. 1985: Radioimmunoassay of bencyclane in human serum. Journal of ...
CALCIUM CHANNEL BLOCKERS BENCYCLANE CALCIUM CHANNEL BLOCKERS BEPRIDIL CALCIUM CHANNEL BLOCKERS CALCIUM CHANNEL BLOCKERS CALCIUM ... VASODILATOR AGENTS BENCYCLANE VASODILATOR AGENTS BEPRIDIL VASODILATOR AGENTS BETAHISTINE VASODILATOR AGENTS CELIPROLOL ... CARDIOVASCULAR AGENTS BENCYCLANE CARDIOVASCULAR AGENTS BENDROFLUMETHIAZIDE CARDIOVASCULAR AGENTS BEPRIDIL CARDIOVASCULAR AGENTS ...
This graph shows the total number of publications written about "Sesquiterpenes, Guaiane" by people in this website by year, and whether "Sesquiterpenes, Guaiane" was a major or minor topic of these publications ...
  • It was concluded that the antiarrhythmic action of bencyclane, based on the use-dependent blockade of sodium channels, might be an important component of the therapeutic effect of bencyclane. (unideb.hu)
  • Do Bencyclane fumarate or Xanthinol nicotinate affect the results of such treatment? (viamedica.pl)
  • Total antioxidant status (TAS) of the plasma and blood levels of nitric oxide also increased in patients treated with bencyclane and pentoxifilline (p (viamedica.pl)
  • This graph shows the total number of publications written about "Bencyclane" by people in this website by year, and whether "Bencyclane" was a major or minor topic of these publications. (ucdenver.edu)
  • The objective of this study was a comparison of bencyclane versus pentoxifilline effects on the clinical picture (pain free walking distance and maximum walking distance) and selected parameters of oxidative stress including blood level of nitric oxide (NO) and total antioxidant status of the plasma in patients with chronic lower limb ischaemia (Fontaine IIb). (viamedica.pl)