Slow channel inhibitor effects on brain function: tolerance to severe hypoxia in the rat. (1/2)
1. The protective effects of ten slow channel inhibitor drugs against severe progressive hypoxia were investigated in rats breathing spontaneously during light anaesthesia. Respiration, heart rate, electrocorticogram (ECoG) and/or electroencephalogram (EEG) were recorded. 2. Tolerance times were monitored from hypoxia onset until cessation of respiration, ECoG, EEG synchronization, and 'background-EEG'. Drugs were administered i.v. 5 min before the onset of hypoxia. 3. Verapamil, gallopamil, and nimodipine resulted in a significant increase of tolerance times; fendiline and bepridil showed a small increase (not significant); bencyclan and prenylamine were ineffective; cinnarizine and diltiazem slightly reduced tolerance times as did flunarizine at low doses. 4. At protective doses, verapamil, gallopamil, and nimodipine significantly raised the respiration rate but had little or no cardiac depressor effects. Bencyclan showed ventilatory drive but cardiocirculatory depression. A clear-cut ventilatory drive did not occur with the other ineffective slow channel inhibitors. 5. It is suggested that the protective actions observed were not due to slow channel inhibition per se, nor to spasmolytic potency or increased cerebral blood flow. Ventilatory drive associated with other cardiopulmonary actions which secondarily raise the brain oxygen supply are likely to be responsible for this effect. (+info)Comparative studies of cerebral vasodilators on relaxation activities in isolated basilar, mesenteric and pulmonary arteries of rabbits. (2/2)
Effects of cerebral vasodilators such as bencyclane, cinnarizine, and papaverine were comparatively studied using helically cut basilar and superior mesenteric arteries and radial muscle preparations of pulmonary arteries with the sympathetic nerve isolated from rabbits. The order of relaxation activities on high K+-induced contractures was cinnarizine>bencyclane>papaverine in basilar strips and cinnarizine>papaverine>bencyclane in mesenteric strips. Relaxation responses of basilar strips to cinnarizine and bencyclane were faster and more marked than those seen in mesenteric strips. Responses to papaverine were equipotent in both preparations. The action of cinnarizine alone was irreversible. In mesenteric strips, the order of the sensitivity of contractile responses to cumulatively applied biogenic amines was serotonin>noradrenaline>histamine. Cinnarizine produced an antihistaminergic action, while bencyclane produced an antiserotonergic action. In pulmonary arteries, 6 x 10(-6) g/ml papaverine inhibited contractile responses to 2, 5, and 25 Hz nerve stimulation in a frequency-independent manner together with inhibition of responses to noradrenaline. Bencyclane at 6 x 10(-6) and 10(-5) g/ml selectively inhibited in a dose-dependent manner contractile responses only to 25 Hz without inhibition of responses to noradrenaline. These results were discussed in comparison with findings of the cerebral vasodilators obtained using other experimental techniques. Spiral strips of basilar arteries from rabbits in combination with peripheral arteries may be used as a simple quantitative, and reproducible screening method in a preclinical stage for drug evaluation of cerebral vasodilators. (+info)New Lung Cancer Drug Shows Dramatic Results for Shrinking Tumors
Dynamic storage in resource-scarce browsing multimedia applications | (1998) | Elenbaas | Publications | Spie
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Nicergoline - DrugBank
Cinnarizine Tablets
Cinnarizine Tablet | Stugeron 25 Mg Tablets | Cinnarizine 25 Mg
Skin and Cerebral Vascular Function / Reactivity in Healthy Young Adul by Kiyoung Kim
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Evo and Proud: June 2011
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Drug - Vasonic 25mg - 10 Tablets Tablet (Cinnarizine) Price List or Cost of Medication | Medindia
Drug - Vertilas 25mg - 210 Tablets Tablet (Cinnarizine) Price List or Cost of Medication | Medindia
AID 400370 - Relaxation activity in guinea pig ileum assessed as relaxation of KCl-induced muscle contractions - PubChem
CLOSED-LOOP MIMO SYSTEMS AND METHODS - Patent application
Neurootologic therapy
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Plus it
Suchergebnisse für Relaxation
Cinnarizine - Wikipedia
Giganten
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Anti-Allergic Agents, Calcium Channel Blockers, Histamine H1 Antagonists, ATC:N07CA02
Aplexal
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Anti-Allergic Agents, Calcium Channel Blockers, Histamine H1 Antagonists, ATC:N07CA02
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Download Anesthesia and Cardiovascular Disease, Volume 31 by Zeljko J. Bosnjak, J. Thomas August, Joseph T. Coyle, M. W. PDF -...
Cycloheptanone
... is a precursor to bencyclane, a spasmolytic agent and vasodilator. Pimelic acid is produced by the oxidative ...
ATC code C04
C04AF01 Kallidinogenase C04AX01 Cyclandelate C04AX02 Phenoxybenzamine C04AX07 Vincamine C04AX10 Moxisylyte C04AX11 Bencyclane ...
List of MeSH codes (D02)
... bencyclane MeSH D02.455.426.392.368.284.900 - tropolone MeSH D02.455.426.392.368.367 - cyclohexanes MeSH D02.455.426.392. ...
List of drugs: Be
... bencyclane (INN) bendacalol (INN) bendamustine (INN) bendazac (INN) bendazol (INN) Bendectin benderizine (INN) Bendopa ...
Bencyclane
... is an antispasmodic, vasodilator, and platelet aggregation inhibitor. Grignard addition of benzylmagnesiumbromide to ... completed the synthesis of bencyclane (3). Clofenciclan J. Elks, ed. (2014). The Dictionary of Drugs: Chemical Data, Structures ...
Bencyclane - Wikipedia
Mefenamic acid
... is generic and is available worldwide under many brand names.[5]. In the US, wholesale price of a weeks supply of generic mefenamic acid has been quoted as $426.90 in 2014. Brand-name Ponstel is $571.70.[13] In contrast, in the UK, a weeks supply is £1.66, or £8.17 for branded Ponstan.[14] In the Philippines, 1 tablet of 500 mg generic mefenamic acid cost PHP25.00 (or the equivalent of US$0.50) as of September 2, 2019.. ...
Chromium Picolinate
Calcium Channel Blockers | DrugBank Online
Lidocaine - Wikipedia
Lidocaine, also known as lignocaine and sold under the brand name Xylocaine among others, is a local anesthetic of the amino amide type. It is also used to treat ventricular tachycardia.[7][8] When used for local anaesthesia or in nerve blocks, lidocaine typically begins working within several minutes and lasts for half an hour to three hours.[8][9] Lidocaine mixtures may also be applied directly to the skin or mucous membranes to numb the area.[8] It is often used mixed with a small amount of adrenaline (epinephrine) to prolong its local effects and to decrease bleeding.[8] If injected intravenously, it may cause cerebral effects such as confusion, changes in vision, numbness, tingling, and vomiting.[7] It can cause low blood pressure and an irregular heart rate.[7] There are concerns that injecting it into a joint can cause problems with the cartilage.[8] It appears to be generally safe for use in pregnancy.[7] A lower dose may be required in those with liver problems.[7] It is generally safe ...
PF-05089771 - Wikipedia
MeSH Browser
Bencyclane Fumarate Narrower Concept UI. M0002308. Registry Number. OZN2MG334O. Terms. Bencyclane Fumarate Preferred Term Term ... Bencyclane Preferred Concept UI. M0002307. Registry Number. 6I97Z6S135. Related Numbers. 2179-37-5. OZN2MG334O. Scope Note. A ... Bencyclane Preferred Term Term UI T004456. Date01/01/1999. LexicalTag NON. ThesaurusID ... Bencyclane Fumarate Desoblit Dilangio compositu Fludilat Fluxema Halidor Pharm Action. Calcium Channel Blockers. Vasodilator ...
C74167|Sulmepride|modify|27-JUN-08|(null)|(null
MeSH Browser
Bencyclane Fumarate Narrower Concept UI. M0002308. Registry Number. OZN2MG334O. Terms. Bencyclane Fumarate Preferred Term Term ... Bencyclane Preferred Concept UI. M0002307. Registry Number. 6I97Z6S135. Related Numbers. 2179-37-5. OZN2MG334O. Scope Note. A ... Bencyclane Preferred Term Term UI T004456. Date01/01/1999. LexicalTag NON. ThesaurusID ... Bencyclane Fumarate Desoblit Dilangio compositu Fludilat Fluxema Halidor Pharm Action. Calcium Channel Blockers. Vasodilator ...
E0000163|Adriamycin|doxorubicin
µ
Bieron
Tytu orygina u: Bencyclane - a new aspect of the mechanism of action in patients with peripheral arterial occlusive disease. ... Tytu orygina u: Bencyclane (halidor, egis) - a new aspect of the mechanism of action in patients with peripheral arterial ... Tytu angielski: Endothelium - derived mechanism of action of bencyclane in patients with peripheral arterial occlusive disease ...
ABORTIFACIENT AGENTS ABORTIFACIENT AGENTS
CALCIUM CHANNEL BLOCKERS BENCYCLANE CALCIUM CHANNEL BLOCKERS BEPRIDIL CALCIUM CHANNEL BLOCKERS CALCIUM CHANNEL BLOCKERS CALCIUM ... VASODILATOR AGENTS BENCYCLANE VASODILATOR AGENTS BEPRIDIL VASODILATOR AGENTS BETAHISTINE VASODILATOR AGENTS CELIPROLOL ... CARDIOVASCULAR AGENTS BENCYCLANE CARDIOVASCULAR AGENTS BENDROFLUMETHIAZIDE CARDIOVASCULAR AGENTS BEPRIDIL CARDIOVASCULAR AGENTS ...