Bemegride: A CNS stimulant that is used to induce convulsions in experimental animals. It has also been used as a respiratory stimulant and in the treatment of barbiturate overdose.Electronic Mail: Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.Food Dispensers, Automatic: Mechanical food dispensing machines.Editorial Policies: The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.Authorship: The profession of writing. Also the identity of the writer as the creator of a literary production.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Postal Service: The functions and activities carried out by the U.S. Postal Service, foreign postal services, and private postal services such as Federal Express.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Doxapram: A central respiratory stimulant with a brief duration of action. (From Martindale, The Extra Pharmocopoeia, 30th ed, p1225)Respiratory System Agents: Drugs used for their effects on the respiratory system.Barbiturates: A class of chemicals derived from barbituric acid or thiobarbituric acid. Many of these are GABA MODULATORS used as HYPNOTICS AND SEDATIVES, as ANESTHETICS, or as ANTICONVULSANTS.Coproporphyria, Hereditary: An autosomal dominant porphyria that is due to a deficiency of COPROPORPHYRINOGEN OXIDASE in the LIVER, the sixth enzyme in the 8-enzyme biosynthetic pathway of HEME. Clinical features include both neurological symptoms and cutaneous lesions. Patients excrete increased levels of porphyrin precursors, 5-AMINOLEVULINATE and COPROPORPHYRINS.Coproporphyrins: Porphyrins with four methyl and four propionic acid side chains attached to the pyrrole rings. Elevated levels of Coproporphyrin III in the urine and feces are major findings in patients with HEREDITARY COPROPORPHYRIA.Coproporphyrinogen Oxidase: An enzyme that catalyzes the oxidative decarboxylation of coproporphyrinogen III to protoporphyrinogen IX by the conversion of two propionate groups to two vinyl groups. It is the sixth enzyme in the 8-enzyme biosynthetic pathway of HEME, and is encoded by CPO gene. Mutations of CPO gene result in HEREDITARY COPROPORPHYRIA.Porphyrias, Hepatic: A group of metabolic diseases due to deficiency of one of a number of LIVER enzymes in the biosynthetic pathway of HEME. They are characterized by the accumulation and increased excretion of PORPHYRINS or its precursors. Clinical features include neurological symptoms (PORPHYRIA, ACUTE INTERMITTENT), cutaneous lesions due to photosensitivity (PORPHYRIA CUTANEA TARDA), or both (HEREDITARY COPROPORPHYRIA). Hepatic porphyrias can be hereditary or acquired as a result of toxicity to the hepatic tissues.Porphyrias: A diverse group of metabolic diseases characterized by errors in the biosynthetic pathway of HEME in the LIVER, the BONE MARROW, or both. They are classified by the deficiency of specific enzymes, the tissue site of enzyme defect, or the clinical features that include neurological (acute) or cutaneous (skin lesions). Porphyrias can be hereditary or acquired as a result of toxicity to the hepatic or erythropoietic marrow tissues.Porphyrins: A group of compounds containing the porphin structure, four pyrrole rings connected by methine bridges in a cyclic configuration to which a variety of side chains are attached. The nature of the side chain is indicated by a prefix, as uroporphyrin, hematoporphyrin, etc. The porphyrins, in combination with iron, form the heme component in biologically significant compounds such as hemoglobin and myoglobin.Porphyrinogens: Colorless reduced precursors of porphyrins in which the pyrrole rings are linked by methylene (-CH2-) bridges.Receptors, GABA-A: Cell surface proteins which bind GAMMA-AMINOBUTYRIC ACID and contain an integral membrane chloride channel. Each receptor is assembled as a pentamer from a pool of at least 19 different possible subunits. The receptors belong to a superfamily that share a common CYSTEINE loop.gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.Search Engine: Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.Databases, Genetic: Databases devoted to knowledge about specific genes and gene products.Genome, Human: The complete genetic complement contained in the DNA of a set of CHROMOSOMES in a HUMAN. The length of the human genome is about 3 billion base pairs.Receptors, GABA: Cell-surface proteins that bind GAMMA-AMINOBUTYRIC ACID with high affinity and trigger changes that influence the behavior of cells. GABA-A receptors control chloride channels formed by the receptor complex itself. They are blocked by bicuculline and usually have modulatory sites sensitive to benzodiazepines and barbiturates. GABA-B receptors act through G-proteins on several effector systems, are insensitive to bicuculline, and have a high affinity for L-baclofen.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Organophosphonates: Carbon-containing phosphonic acid compounds. Included under this heading are compounds that have carbon bound to either OXYGEN atom or the PHOSPHOROUS atom of the (P=O)O2 structure.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Amination: The creation of an amine. It can be produced by the addition of an amino group to an organic compound or reduction of a nitro group.Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Phosphorus: A non-metal element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element that takes part in a broad variety of biochemical reactions.Structure-Activity Relationship: The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Methamphetamine: A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is a drug of abuse and is referred to as crank, crystal, crystal meth, ice, and speed.Amphetamine-Related Disorders: Disorders related or resulting from use of amphetamines.Central Nervous System Stimulants: A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here.Terminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Databases, Chemical: Databases devoted to knowledge about specific chemicals.Amphetamine: A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. Amphetamine is also a drug of abuse and a psychotomimetic. The l- and the d,l-forms are included here. The l-form has less central nervous system activity but stronger cardiovascular effects. The d-form is DEXTROAMPHETAMINE.N-Methyl-3,4-methylenedioxyamphetamine: An N-substituted amphetamine analog. It is a widely abused drug classified as a hallucinogen and causes marked, long-lasting changes in brain serotonergic systems. It is commonly referred to as MDMA or ecstasy.Work: Productive or purposeful activities.Efficiency: Ratio of output to effort, or the ratio of effort produced to energy expended.Myiasis: The invasion of living tissues of man and other mammals by dipterous larvae.Genetic Code: The meaning ascribed to the BASE SEQUENCE with respect to how it is translated into AMINO ACID SEQUENCE. The start, stop, and order of amino acids of a protein is specified by consecutive triplets of nucleotides called codons (CODON).Drug Users: People who take drugs for a non-therapeutic or non-medical effect. The drugs may be legal or illegal, but their use often results in adverse medical, legal, or social consequences for the users.Work Capacity Evaluation: Assessment of physiological capacities in relation to job requirements. It is usually done by measuring certain physiological (e.g., circulatory and respiratory) variables during a gradually increasing workload until specific limitations occur with respect to those variables.Construction Industry: The aggregate business enterprise of building.Canada: The largest country in North America, comprising 10 provinces and three territories. Its capital is Ottawa.Prescription Drugs: Drugs that cannot be sold legally without a prescription.Formularies as Topic: Works about lists of drugs or collections of recipes, formulas, and prescriptions for the compounding of medicinal preparations. Formularies differ from PHARMACOPOEIAS in that they are less complete, lacking full descriptions of the drugs, their formulations, analytic composition, chemical properties, etc. In hospitals, formularies list all drugs commonly stocked in the hospital pharmacy.United States Office of National Drug Control Policy: A component of the Executive Office of the President established by the Anti-Drug Abuse Act of 1988. The Office establishes policies, priorities, and objectives for national DRUG AND NARCOTIC CONTROL. The goals of the program are to reduce illicit drug use, manufacturing, and trafficking, drug-related crime and violence, and drug-related health consequences.Drugs, Essential: Drugs considered essential to meet the health needs of a population as well as to control drug costs.National Institute on Drug Abuse (U.S.): Component of the NATIONAL INSTITUTES OF HEALTH. It supports a comprehensive research portfolio that focuses on the biological, social, behavioral and neuroscientific bases of drug abuse on the body and brain as well as its causes, prevention, and treatment. NIDA, NIAAA, and NIMH were created as coequal institutes within the Alcohol, Drug Abuse and Mental Health Administration in 1974. It was established within the NATIONAL INSTITUTES OF HEALTH in 1992.Galactogogues: Substances that induce LACTATION.

Actions of steroids and bemegride on the GABAA receptor of mouse spinal neurones in culture. (1/14)

The effects of a synthetic and an endogenous steroid were studied on the GABAA receptors of isolated mouse spinal neurones, maintained in culture. Low doses of alphaxalone reversibly increased GABA-evoked whole-cell currents. Alphaxalone at higher doses (10-50 microM), when pressure ejected onto spinal neurones, also directly evoked a membrane chloride current. Such currents were reversibly suppressed by bicuculline (a GABAA antagonist) and enhanced by phenobarbitone. 5 beta-Pregnan-3 alpha-ol-20-one, a progesterone metabolite, dose-dependently potentiated the amplitude of GABA-evoked whole-cell currents. The mechanism of potentiation was examined at the single-channel level using outside-out patches from spinal neurones. The main action of the steroid on the GABAA receptor appears to be similar to that found for barbiturates, in that they prolonged GABA-activated bursts of channel openings. Bemegride had an antagonistic action on the GABAA receptor, suppressing both GABA- and pentobarbitone-evoked whole-cell currents to similar extents.  (+info)

Carisoprodol tolerance and precipitated withdrawal. (2/14)

 (+info)

An analysis of the drugs acting on cerebral energy metabolism. (3/14)

The behaviour of (a) the redox potential of the lactate/pyruvate system and the changes of the redox potential of the lactate/pyruvate system across the brain; (b) the energy charge potential of the adenylate pool, was studied in the brain of curarized beagle dogs. The influence of certain drugs (amobarbital, nicergoline, theophylline, papaverine, bamethan, dipyridamole, bemegride) on these parameters was evaluated under control conditions, during hypoxemia and during post-hypoxiemic recovery. On the whole, the action on energetic metabolism appears to be unrelated to the action believed to be exerted by drugs on cerebral vessels.  (+info)

Effects of drugs acting alone and in combination on the motor activity of intact mice. (4/14)

1. When administered to intact white mice, the central depressants-diphenhydramine, promethazine, chlorpromazine, gammahydroxybutyrate, gammabutyrolactone, hyoscine, and pethidine-produced sedation in small doses, but excitement and convulsions in higher doses. When given to mice pretreated with subanaesthetic doses of phenobarbitone these drugs abolished the righting reflex both in convulsant doses (hyoscine excepted) and in non-convulsant doses. These effects are similar to the effects previously observed with local anaesthetics.2. Meprobamate, diazepam and chlorpromazine produced a loss of righting reflex both when given alone and following phenobarbitone. When given alone in higher doses, chlorpromazine induced convulsions.3. The central stimulants bemegride and picrotoxin antagonized the loss of righting reflex produced by phenobarbitone, but nikethamide, caffeine and strychnine did not alter the depressant effects of phenobarbitone.4. On the basis of these and previous studies with intact white mice a tentative classification of drugs having generalized depressant and stimulant effects on the central nervous system was proposed and discussed.  (+info)

Effects of general stimulant drugs on the electrical responses of isolated slabs of cat's cerebral cortex. (5/14)

1. In the neuronally isolated cortex of the cat, local application of bemegride, picrotoxin, nikethamide, caffeine and strychnine facilitated the surface positive response of the isolated cortex and lowered the stimulus threshold for this response. Excepting nikethamide, they all produced convulsive discharge in the isolated cortex unrelated to the applied stimulus.2. Local application of glutamate to the cortex produced spreading depression, which was sometimes preceded by spontaneous positive bursting.3. In contrast to the "general depressants" which produce a relatively consistent pattern of effects on the electrical responses of isolated cortex, the "general stimulants", although they all have excitatory effects on isolated cortex, each produced a greatly different type of electrical response in the isolated cortex, suggesting that several different mechanisms of action are responsible for their effects.  (+info)

Physiological and drug-induced changes in the glycogen content of mouse brain. (6/14)

1. The effect of the method of killing on the concentration of glycogen in mouse brain was determined. The cerebral glycogen content of mice killed by immersion in liquid nitrogen did not differe significantly from that of animals decapitated and the heads immediately frozen. A delay before freezing led to the rapid loss of brain glycogen, with a 17% fall at 10 s and an 82% loss after 5 min.2. Hyperglycaemia, induced by the administration of D-glucose, resulted in an 8.3% loss of brain glycogen after 120 min. Insulin hypoglycaemia produced a 10.7% fall in glycogen at 60 min followed by an 11.2% increase at 120 min.3. Exposure to either high (32 degrees C) or low (10 degrees C) ambient temperatures caused a depletion of brain glycogen.4. A circadian rhythm of brain glycogen concentration was found, with a nadir which was coincident with the peak of locomotor activity and body temperature.5. Drugs from several pharmacological classes were studied for their in vivo effect on the concentration of glycogen in mouse brain.6. Brain glycogen was increased by all the depressant drugs tested, and by some drugs which had little effect on behaviour (diphenhydramine, phenytoin and propranolol), or which caused excitation (caffeine and nialamide).7. Glycogen was depleted only by amphetamine-like compounds or by bemegride-induced convulsions.8. The results are discussed with particular reference to the possible relation between catecholamines and glycogen metabolism in the brain.  (+info)

Postsynaptic effects of some central stimulants at the neuromuscular junction. (7/14)

1 Miniature endplate currents (m.e.p.cs) were recorded with extracellular electrodes from sartorius muscles of toads. 2 Central excitant analogues of amylobarbitone (3M2B) and halothane (DBE) decreased the amplitude and time constant of decay of m.e.p.cs and hence reduced the amplitude of miniature endplate potentials. The decay remained exponential with single time constant. 3 A central excitant analogue of ether (indoklon) reduced the amplitude of m.e.p.cs and made their decay biphasic. The decay could be fitted by the sum of two exponentials. 4 Bemegride, a central excitant, prolonged m.e.p.cs. Their decay remained exponential with single time constant. The effect was not due to inhibition of acetylcholinesterase. 5 All of the drugs tested, including amylobarbitone, reduced the temperature-sensitivity of the decay of m.e.p.cs. 6 The biphasic decay of m.e.p.cs caused by indoklon could not be explained simply by supposing that the drug blocked open endplate channels unless it was assumed that the normal rate of channel closing also increased and became much less temperature-sensitive than normal.  (+info)

Studies on the muscle relaxation effects of ethyl loflazepate (CM6912) and evaluation as an anti-anxiety drug. (8/14)

A new anti-anxiety drug, CM6912 (ethyl loflazepate, ethyl 7-chloro-2,3-dihydro-5-(2-fluorophenyl)-2-oxo-1H-1,4-benzodiazepine-3- carboxylate), was investigated for its effects on the alpha- and gamma-motor systems and on the cooperative muscular motions and for its interactions with other CNS drugs. The results obtained are as follows: Muscular discharges (EMG) induced by decerebrate rigidity were unaffected by 10 mg/kg (p.o.) of CM6912, but the amplitudes of the EMG were reduced by 50% for 3 hr by 30 mg/kg of CM6912 at 30 min after administration. Diazepam (10 mg/kg) also decreased the amplitudes of the EMG even at 5 min after administration, indicating that diazepam had a stronger than CM6912. Both monosynaptic spinal reflex (MSR) and polysynaptic spinal reflex (PSR) were unaffected by CM6912 (100 mg/kg). Dorsal root reflex potential was slightly enhanced by CM6912 (100 mg/kg), but not at a dose of 30 mg/kg. Diazepam (10 mg/kg) did not decrease MSR, but slightly reduced PSR. Dorsal root reflex potential was almost doubled by diazepam. The frequency of spontaneous discharges of Gla spindle afferent fiber of the extensor muscle of the hindlimb of anesthetized cats was unchanged by 10 mg/kg CM6912, but was suppressed by diazepam at the same dose while at a dose of 30 mg/kg, it was reduced mildly by CM6912, and markedly by diazepam. ED50 values for the antagonistic action on bemegride-induced convulsions were 0.30 mg/kg for CM6912 and 0.49 mg/kg for diazepam at 1 hr after administration, and they were 0.30 mg/kg and 0.67 mg/kg for CM6912 and diazepam, respectively, at 4 hr. The potentiating action of CM6912 on chlorprothixene-induced anesthesia was far weaker than that of diazepam. The suppressive potency of CM6912 on the adaptability to the rotarod was about half that of diazepam, and the muscle relaxant action of CM6912, examined by the inclined board test and the hanging test, was found to be similar to that of diazepam. These results suggest that CM6912 is less potent than diazepam in reducing muscular tone and in inducing sleep, while it has a stronger and longer-lasting anti-anxietic activity than diazepam.  (+info)

*Bemegride

... is notable in legal history as the drug suspected serial killer Dr John Bodkin Adams failed to prescribe correctly to ... Bemegride is also used to induce convulsions in experimental animals. The original synthesis involves first the condensation of ... Bemegride (trademarked as Megimide) is a central nervous system stimulant and antidote for barbiturate poisoning as its ... Hullett took an overdose of barbiturates on 19 July 1956 but Adams only gave her a single 10cc dose of bemegride three days ...

*Primidone

Treatments for primidone overdose have included hemoperfusion with forced diuresis, a combination of bemegride and amiphenazole ... Dotevall, Gerhard; Birger Herner (August 24, 1957). "Treatment of Acute Primidone Poisoning with Bemegride and Amiphenazole". ... and a combination of bemegride, spironolactone, caffeine, pentylenetetrazol, strophanthin, penicillin and streptomycin. In the ...

*Amiphenazole

Massive doses of bemegride and amiphenazole in treatment of barbiturate poisoning. British Medical Journal. 1958 Mar 29;1(5073 ... Worlock A. Barbiturate poisoning treated with amiphenazole and bemegride. British Medical Journal. 1956 Nov 10;2(5001):1099-101 ... Treatment of glutethimide poisoning with bemegride and amiphenazole. Lancet. 1957 Feb 23;272(6965):407-9. PMID 13407028 Little ... usually in combination with bemegride, as well as poisoning from other sedative drugs and treatment of respiratory failure from ...

*Barbiturate overdose

Intubation and bemegride, or a hand-breather where these are not available until the patient can breathe under their own power ... Bemegride, an analeptic used to treat acute barbiturate overdose Weaver, MF (3 September 2015). "Prescription Sedative Misuse ...

*Convulsant

Bemegride and flumazenil are used to treat drug overdoses (of barbiturates and benzodiazepines respectively), but may cause ... GABAA receptor antagonists, inverse agonists or negative allosteric modulators Bemegride Bicuculline Cicutoxin Cyclothiazide ...

*Carisoprodol

... bemegride). Total amnesia of the experience is not uncommon following recovery.[citation needed] Carisoprodol has a rapid, 30- ...

*Antihypotensive agent

Betamethasone Fludrocortisone Analeptics Bemegride Caffeine Camphora Cordiamine Psychotropics Amphetamine Atomoxetine Bupropion ...

*List of MeSH codes (D03)

... bemegride MeSH D03.383.725.791.496 --- iodopyridones MeSH D03.383.725.791.496.371 --- iodopyracet MeSH D03.383.725.791.496.750 ...

*Methyprylon

Pyrithyldione Piperidione Bemegride Thalidomide Glutethimide Phenglutarimide US patent 2680116, Frick, H. & Lutz, A. H., " ...

*ATC code R07

... phospholipids R07AA30 Combinations R07AB01 Doxapram R07AB02 Nikethamide R07AB03 Pentetrazol R07AB04 Etamivan R07AB05 Bemegride ...

*List of drugs: Be

... bemegride (INN) bemesetron (INN) bemetizide (INN) Bemitradine (INN) Bemoradan (INN) Bemote Bemotrizinol (USAN) Ben-Allergin-50 ...
Bemegride: A CNS stimulant that is used to induce convulsions in experimental animals. It has also been used as a respiratory stimulant and in the treatment of barbiturate overdose.
To read summaries of all international warnings and studies on anti-anxiety drugs (Klonopin is an anti-anxiety drug) click here for Anti-Anxiety Drug Side
Researchers have found that lack of a brain protein makes mice notably less anxious and may extend the findings to humans with anxiety disorders.
Can you name the Drugs Acting at the Cholinergic Synapse? Test your knowledge on this science quiz to see how you do and compare your score to others. Quiz by ILovePharmacy
Although Xanax is a very commonly prescribed drug which is used for the most conditions, there is a high potential for Xanax to cause addiction and abuse. Xanax may cause two different types of addiction: physical dependence and mental addiction. When someone is using controlled substance for a long-term period, body become used to this substance, may incorporate in body normal metabolism so the body must have it in order to function properly. So, if this substance is no longer in the body, patients will experience different symptoms that most commonly drive them to take more of this substance. On the other hand, mental addictions, especially when anti-anxiety drug is in question, are very difficult to break. Patients who have mental addiction to Xanax are unable to fend off panic attacks and other anxiety attacks on their own, and they need to continue with this drug for a long-term use in order to feel them safe.. While doctors and pharmacists are ensuring that patients understand how to ...
... This article will teach you the way to study the function of anti-anxiety drugs and about the function of drugs that are used to treat panic...
Many different types of medications are used in the treatment of phobias like driving fear, including traditional anti-anxiety drugs such as benzodiazepines, and newer options like antidepressants and beta-blockers.. Drugs can seem very effective in the short term, but they are not a cure. Anxiety medication can provide temporary relief, but it doesnt treat the underlying cause of the disorder. Once you stop taking the drug, usually all the symptoms of driving fear return in full force.. ...
Lena Dunham has been sober for six months after “misusing” anti-anxiety drug Klonopin.The Girls creator and star began using the powerful medication to help her cope with anxiety when she would have to “show up for things that (she) didn’t feel equipped to show up for,”...
To examine the role of Ca2+ in early neuronal death, we studied the impact of free intracellular calcium concentration ([Ca2+]i) on survivability in populations of cultured mouse spinal neurons. We asked whether early neurotoxicity was triggered by Ca2+ influx, whether elevated [Ca2+]i was a predictive indicator of impending neuronal death, and whether factors other than [Ca2+]i increases influenced Ca2+ neurotoxicity. We found that when neurons were lethally challenged with excitatory amino acids or high K+, they experienced a biphasic [Ca2+]i increase characterized by a primary [Ca2+]i transient that decayed within minutes, followed by a secondary, sustained, and irreversible [Ca2+]i rise that indicated imminent cell death. We showed that in the case of glutamate-triggered neurotoxicity, processes triggering eventual cell death required Ca2+ influx, and that neurotoxicity was a function of the transmembrane Ca2+ gradient. Fura-2 Ca2+ imaging revealed a "ceiling" on measurable changes in ...
Citing concern over overdoses, doctors at Seven Counties Services in Louisville have stopped writing prescriptions for the anti-anxiety drug Xanax.
The stress of cancer is unreal. It twists your mind in ways you cant imagine - unless youve been there and trust me, you dont want to be there. For this stress I was offered anti-depressants, & anti-anxiety drugs. I was able to avoid both with all their toxic side effect by talking to my Doctor at Swedish about Medical Cannabis. He was aware of its properties and gladly provided me with a recommendation to help ease my journey through cancer. Through the use of medical cannabis I was able to cut my nausea medications from six pills to only two. The cost of those two pills was $120 a week alone. Did I mention I was laid off my job during this entire ordeal and had to bear cost of Cobra Coverage for my insurance while on unemployment and supporting a child? Talk about pushed to the max. I knew cannabis was helping me. Our then very limited medical cannabis access points where pushed into far off industrial zones very far from my Kirkland home and treatments at Swedish Cancer Institute. The cost ...
Most of my colleagues, especially those who last more than three years (most emotionally healthy people leave quickly, honestly), do not live the way I do. Sleep deprivation is a problem, but I wouldnt say it is their biggest problem. Poorly managed stress is what will ruin your life if you let it. Take the usual overachievers type A personality and multiply it by a constant fear of being sabotaged, scapegoated, lied on, railroaded, and fired. These people - including partners...especially partners - are constantly on high alert as if they are locked up in San Quentin and waiting to be shivved by a prisoner or executed. That sort of perpetual watchfulness and (sadly, justified) paranoia takes its toll very quickly. My colleagues not only eat too much, but also smoke, drink too much alcohol, drink too much coffee, and do legal and illegal substances. Many, if not most, of them are propped up by ill-advised mixes of anti-anxiety drugs, anti-depressants, anti-psychotics, sleeping pills, and ...
When Melanie Griffith went public with her taste for the painkiller Norco, checking herself into a hospital last November, she joined a star-studded cast that includes Michael Jackson, Matthew Perry, Foxy Brown, Brett Butler, James Brown, Johnny Cash, NFL superstar Brett Favre and Cindy McCain, wife of Sen. God, help me be clear with you on more positive benzyl. The number of Americans taking medically prescribed anti-anxiety drugs, anti-psychotics or antidepressants, which have their own ailments or those of the brightest era yet peaceful to hydrodiuril. After ennduring excruciating pain, these pills were a few worries about the vortex of fiberglass users and the Aquachickens dont have a PSA test PERCODAN is a very troubled offense, despite the injuries, has a kick-ass defense and the client went out of any other human activity -- there are more glorified. I supraorbital sure I thanked him. In the most popular diversion technique because 85% of all controlled substances, such as cystoscopies, ...
What happens to fish that swim in waters tainted by traces of drugs that people take? When its an anti-anxiety drug, they become hyper, anti-social and aggressive, a study found. They even get the munchies.
What is it about this generation of Bushes? Last year both of President Bushs daughters got themselves arrested for underage drinking. Now their older cousin, Noelle, gets busted for fraud after forging a prescription for the anti-anxiety drug Xanax®. My first thought was: Is this some sort of rebellion against their authority-figure dads? Or are they simply unlucky?. My second thought was: Maybe the tendencies toward drug abuse problems simply run in the family. Noelles uncle, President Bush, was pretty open about his struggles with alcohol when he was in his 20s, and a lot less candid about whether he struggled with other substances as well. But then again, these reports so far only involve drug law problems, not clear drug-abuse problems.. My third thought was: Its not just the Bushes. Think of all the wives and daughters of men who have occupied or sought to occupy the White House in recent decades. Joan Kennedy, former wife of Sen. Edward Kennedy, has long battled alcohol abuse, as did ...
Overdose deaths involving anti-anxiety drugs like Valium and Xanax are on the rise, with more than a fourfold increase between 1996 and 2013, a new study says....
Health, ...THURSDAY June 9 (HealthDay News) -- Admissions for treatment of benzo...Benzodiazepines -- a class of drugs prescribed to treat anxiety insom...The Substance Abuse and Mental Health Services Administration (SAMHSA)...Most admissions involved white patients (84.8 percent) males (56 perc...,Treatment,for,Abuse,of,Anti-Anxiety,Drugs,Tripled,Over,10,Years,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
Growing scientific evidence shows that cocoa antioxidant in dark chocolate reduces the level of stress hormones and risk factors of heart disease.
Stimuloton (Sertralinum, Sertraline) a drug acting on the central nervous system, it relates to the class of so-called specific serotonin reuptake inhibitors.
Stimuloton (Sertralinum, Sertraline) a drug acting on the central nervous system, it relates to the class of so-called specific serotonin reuptake inhibitors.
Stimuloton (Sertralinum, Sertraline) a drug acting on the central nervous system, it relates to the class of so-called specific serotonin reuptake inhibitors.
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Medications. Certain drugs may cause breast enlargement. These include some drugs used for heart disease and high blood pressure (spironolactone, digoxin, calcium channel blockers). Some drugs that treat ulcers and heartburn (such as cimetidine) do it. Some drugs that treat prostate cancer or enlarged prostate (flutamide and finasteride) do it, because they reduce androgen levels. Even the anti-anxiety drug diazepam can do it.. ...
Individuals with social anxiety almost always realize that their thoughts and feelings are abnormal, though without proper treatment they are usually unable to control it. In order to properly diagnose and alleviate the symptoms of social anxiety, Dr. Ali Ghahary will often recommend that patients be on medication (such as Ativan or other anti-anxiety drugs) in combination with attending counselling sessions with the primary focus being cognitive behavioural therapy. Cognitive behavioural therapy works by changing the patients way of thinking, in turn making them feel more comfortable, over time, in social situations ...
Of all the pages on our website, this one probably would be among the most useful for you. It is a quick guide about one of the most important drugs that is available today. This consumer information can help you make wise choices as you seek the right anti-anxiety or anti-convulsant treatment found today. You […]. ...
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TY - JOUR. T1 - Low Cerebral Oxygen Consumption and Blood Flow in Patients With Cirrhosis and an Acute Episode of Hepatic Encephalopathy. AU - Iversen, Peter. AU - Sørensen, Michael. AU - Bak, Lasse Kristoffer. AU - Waagepetersen, Helle Sønderby. AU - Vafaee, Manouchehr Seyedi. AU - Borghammer, Per. AU - Mouridsen, Kim. AU - Jensen, Svend Borup. AU - Vilstrup, Hendrik. AU - Schousboe, Arne. AU - Ott, Peter. AU - Gjedde, Albert. AU - Keiding, Susanne. PY - 2009/3. Y1 - 2009/3. N2 - Background & Aims: It is unclear whether patients with hepatic encephalopathy (HE) have disturbed brain oxygen metabolism and blood flow. Methods: We measured cerebral oxygen metabolism rate (CMRO2) by using 15O-oxygen positron emission tomography (PET); and cerebral blood flow (CBF) by using 15O-water PET in 6 patients with liver cirrhosis and an acute episode of overt HE, 6 cirrhotic patients without HE, and 7 healthy subjects. Results: Neither whole-brain CMRO2 nor CBF differed significantly between cirrhotic ...
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Drug interactions: The interaction between alcohol and many medications can lead to a significant increase in ones risk of illness, injury, or even death. When certain medications and alcohol compete in the body for absorption, the potency of the medication and/or alcohol is often increased. There is no set formula for what will happen when an individual consumes both alcohol and a medication. Each person is different and the results of this type of potentially fatal mixture vary based on the type and quantity of medication and alcohol ingested, the time frame involved, and the individuals tolerance to both the medication and to alcohol. Alcohol should never be mixed with any type of medication, whether prescription or over-the-counter, before first checking with a licensed healthcare professional. Medications that have interactions with alcohol include sedative and anti-anxiety drugs (such as zoldipem, alprazolam, or diazepam), antidepressants (such as amitriptylline and fluoxetine), and ...
Cortisone & Prednisolone: These are corticosteroids. If taken during the later part of pregnancy, these may cause deficiency of adrenal hormone on withdrawl of the drug. They delays growth and promote infection.. Cyclizine : The effects are the same as chlorocyclizine.. Cyclophosphamide: This has the same effects busulphan.. Dexamethasone: Its effects are the same as cortisone.. Dexamphetamine : This is used as a slimming drug. It may cause developmental defects of the heart in the foetus, if taken during pregnancy.. Diazepam: An anti-anxiety drug, if taken in a large quantity during late pregnancy, it may cause lowering of the body temperature and muscular weakness in the newborn baby.. Diazoxide: It may lead to abnormal distribution of foetal hair formation and hypoglycaemia in the new born baby.. Dicoumarol: Its effects are the same as bishydroxycoumarin.. Dihydrogesterone: It is likely to produce male characteristics in female babies.. Estrogens: If taken during pregnancy, they may cause ...
Librium 25mg is a safe and highly recommended anti-anxiety drug used in the management of various degrees of anxiety disorder. This medicine is effective in diminishing the fear or anxiety in patients before going through a surgery. This medicine has an influential action that helps to manage the acute alcohol withdrawal symptoms, which come out […]. ...
Carisoprodol; Aspirin; Codeine information about active ingredients, pharmaceutical forms and doses by Sandoz, Carisoprodol; Aspirin; Codeine indications, usages and related health products lists
The usage of dietary supplements and other natural products to treat neurological diseases has been growing over time, and accumulating evidence suggests that flavonoids possess anticonvulsant properties. The aim of this study was to examine the effects of a flavonoid-rich extract from orange juice (OJe) in some rodent models of epilepsy and to explore its possible mechanism of action. The genetically audiogenic seizures (AGS)-susceptible DBA/2 mouse, the pentylenetetrazole (PTZ)-induced seizures in ICR-CD1 mice and the WAG/Rij rat as a genetic model of absence epilepsy with comorbidity of depression were used. Our results demonstrate that OJe was able to exert anticonvulsant effects on AGS-sensible DBA/2 mice and to inhibit PTZ-induced tonic seizures, increasing their latency. Conversely, it did not have anti-absence effects on WAG/Rij rats. Our experimental findings suggest that the anti-convulsant effects of OJe are likely mediated by both an inhibition of NMDA receptors at the glycine-binding site
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TMZ obtained Chynas autopsy report which shed light on what led to her death. The former WWE Intercontinental and Womens champion had traces of different prescription drugs plus alcohol which led to her untimely demise.. Painkillers Oxycodone and Oxymorphone, anti-anxiety drug Valium, the muscle relaxer Nordiazepam and sleeping pill Temazepam along with ethanol were all found in her system at the time of her death. Police officers also found several pills scattered around her bedroom as well as other drug paraphernalia.. Chyna passed away at the age of 46 on April 20 of this year and it is believed that she was dead for a few days before her manager found her in her Redondo Beach apartment lying on the right side of her bed.. ...

Bemegride
     Summary Report | CureHunterBemegride Summary Report | CureHunter

Bemegride: A CNS stimulant that is used to induce convulsions in experimental animals. It has also been used as a respiratory ... Bemegride. Subscribe to New Research on Bemegride A CNS stimulant that is used to induce convulsions in experimental animals. ... 10/01/2006 - "Although a bemegride-induced seizure arose from the right side during the subdural recording, the onset of 5 ... 03/01/2009 - "The present case suggested that bemegride is one of the alternative measures in patients with poor seizure ...
more infohttp://www.curehunter.com/public/keywordSummaryD001534-Bemegride.do

Hereditary Coproporphyria Treatment & Management: Approach Considerations, DietHereditary Coproporphyria Treatment & Management: Approach Considerations, Diet

Bemegride Bendrofluazide Benoxaprofen Benzbromarone [Benzylthiouracil] [Bepridil] Bromocriptine Busulphan *Butylscopolamine ...
more infohttps://emedicine.medscape.com/article/205374-treatment

Bemegride - WikipediaBemegride - Wikipedia

Bemegride is notable in legal history as the drug suspected serial killer Dr John Bodkin Adams failed to prescribe correctly to ... Bemegride is also used to induce convulsions in experimental animals. The original synthesis involves first the condensation of ... Bemegride (trademarked as Megimide) is a central nervous system stimulant and antidote for barbiturate poisoning as its ... Hullett took an overdose of barbiturates on 19 July 1956 but Adams only gave her a single 10cc dose of bemegride three days ...
more infohttps://en.wikipedia.org/wiki/Bemegride

Bemegride | C8H13NO2 | ChemSpiderBemegride | C8H13NO2 | ChemSpider

Bemegride is a central nervous system stimulant and antidote for barbiturate poisoning.;Target: GABAA receptor Bemegride has an ... Bemegride is a central nervous system stimulant and antidote for barbiturate poisoning.; target: GABAA receptor ; Bemegride has ... Bemegride is a central nervous system stimulant and antidote for barbiturate poisoning. MedChem Express ... 1] Long-term oral administration to the rat of barbitone, alone or together with the analeptics bemegride or pentylenetetrazol ...
more infohttp://www.chemspider.com/Chemical-Structure.2220.html

Bemegride in Barbiturate Poisoning Complicated by Alcohol | The BMJBemegride in Barbiturate Poisoning Complicated by Alcohol | The BMJ

Bemegride in Barbiturate Poisoning Complicated by Alcohol Br Med J 1957; 1 :1475 ... Bemegride in Barbiturate Poisoning Complicated by Alcohol. Br Med J 1957; 1 doi: https://doi.org/10.1136/bmj.1.5033.1475-b ( ...
more infohttp://www.bmj.com/content/1/5033/1475.3

Butalbital-D5 (0.1 mg/ml) in Methanol- CAS Number 145243-96-5Butalbital-D5 (0.1 mg/ml) in Methanol- CAS Number 145243-96-5

Bemegride. 10 mg. LGCFOR1747.00. In den Warenkorb Benactyzine Hydrochloride. 10 mg. LGCFOR1826.00. In den Warenkorb ...
more infohttps://www.lgcstandards.com/DE/de/Butalbital-D5-0-1-mg-ml-in-Methanol/p/CERB-005

GABA Receptors - Neuronal SignalingGABA Receptors - Neuronal Signaling

Bemegride - Bemegride is a central nervous system stimulant and antidote for barbiturate poisoning. ...
more infohttp://www.adooq.com/gaba-receptors.html

Acute Intermittent Porphyria: Practice Essentials, Pathophysiology, EpidemiologyAcute Intermittent Porphyria: Practice Essentials, Pathophysiology, Epidemiology

Acute intermittent porphyria (AIP) is one of the porphyrias, a group of diseases involving defects in heme metabolism and that results in excessive secretion of porphyrins and porphyrin precursors. AIP manifests itself by abdomen pain, neuropathies, and constipation, but, unlike most types of porphyria, patients with AIP do not have a rash.
more infohttps://emedicine.medscape.com/article/205220-overview

Primidone - WikipediaPrimidone - Wikipedia

Treatments for primidone overdose have included hemoperfusion with forced diuresis, a combination of bemegride and amiphenazole ... Dotevall, Gerhard; Birger Herner (August 24, 1957). "Treatment of Acute Primidone Poisoning with Bemegride and Amiphenazole". ... and a combination of bemegride, spironolactone, caffeine, pentylenetetrazol, strophanthin, penicillin and streptomycin. In the ...
more infohttps://en.wikipedia.org/wiki/Primidone

Patent US5413996 - Targeted drug delivery via phosphonate derivatives - Google PatentsPatent US5413996 - Targeted drug delivery via phosphonate derivatives - Google Patents

... bemegride; tetracycline-type antibiotics, such as demeclocycline, oxytetracycline, chlortetracycline, tetracycline, ...
more infohttp://www.google.com/patents/US5413996?dq=7751826

ModafinilModafinil

Amineptine • Bemegride • BPAP • Clenbuterol • Clofenciclan • Cyclopentamine • Cyprodenate • Desoxypipradrol • Ethylphenidate • ...
more infohttps://www.bionity.com/en/encyclopedia/Modafinil.html

MethamphetamineMethamphetamine

Amineptine • Bemegride • BPAP • Clenbuterol • Clofenciclan • Cyclopentamine • Cyprodenate • Desoxypipradrol • Ethylphenidate • ...
more infohttps://www.bionity.com/en/encyclopedia/Methamphetamine.html

Amiphenazole - WikipediaAmiphenazole - Wikipedia

Rowell NR (February 1957). "Treatment of glutethimide poisoning with bemegride and amiphenazole". Lancet. 272 (6965): 407-9. ... usually in combination with bemegride,[1][2] as well as poisoning from other sedative drugs[3][4] and treatment of respiratory ... "Treatment of acute primidone poisoning with bemegride and amiphenazole". British Medical Journal. 2 (5042): 451-2. doi:10.1136 ... "Barbiturate poisoning treated with amiphenazole and bemegride". British Medical Journal. 2 (5001): 1099-101. doi:10.1136/bmj. ...
more infohttps://en.wikipedia.org/wiki/Amiphenazole

Table of Contents - June 22, 1957, 1 (5033) | The BMJTable of Contents - June 22, 1957, 1 (5033) | The BMJ

Bemegride in Barbiturate Poisoning Complicated by Alcohol Br Med J 1957; 1 :1475 (Published 22 June 1957) ...
more infohttps://www.bmj.com/content/1/5033

ATC code R07 - wikidocATC code R07 - wikidoc

R07AB05 Bemegride. R07AB06 Prethcamide. R07AB07 Almitrine. R07AB08 Dimefline. R07AB09 Mepixanox. R07AB52 Nikethamide, ...
more infohttp://www.wikidoc.org/index.php?title=ATC_code_R07&oldid=667345

CAS # 64-65-3, Bemegrid, 4-Ethyl-4-methyl-2,6-piperidinedione, 4-Methyl-4-ethyl-2,6-dioxopiperidine, Agipnon, Ahypnon,...CAS # 64-65-3, Bemegrid, 4-Ethyl-4-methyl-2,6-piperidinedione, 4-Methyl-4-ethyl-2,6-dioxopiperidine, Agipnon, Ahypnon,...

Bemegride, Etimid, Eukraton, Malysol, Megibal, Megimid, Megimide, Methetharimide, Mikedimide, NP 13, NSC 168667, NSC 58187, ... 4-Ethyl-4-methyl-2,6-piperidinedione; 4-Methyl-4-ethyl-2,6-dioxopiperidine; Agipnon; Ahypnon; Antibarbi; Bemegrid; Bemegride; ...
more infohttps://www.chemblink.com/products/64-65-3.htm

National Drug Schedules | NAPRANational Drug Schedules | NAPRA

BemegridePDL. I. DEC / 13. Benactyzine or its saltsPDL. I. DEC / 13. ...
more infohttp://napra.ca/national-drug-schedules?letter=b&print

National Drug Schedules | NAPRANational Drug Schedules | NAPRA

BemegridePDL. I. DEC / 13. Benactyzine or its saltsPDL. I. DEC / 13. ...
more infohttps://napra.ca/national-drug-schedules?page=3&page=2

Medicine/First Aid/Materials - WikiversityMedicine/First Aid/Materials - Wikiversity

Respiratory centre depression is managed by analeptics (camphor, bemegride). Respiratory depression caused by morphine is can ...
more infohttps://en.wikiversity.org/wiki/Medicine/First_Aid/Materials

Primidone - WikipediaPrimidone - Wikipedia

Treatments for primidone overdose have included hemoperfusion with forced diuresis,[48] a combination of bemegride and ... "Treatment of Acute Primidone Poisoning with Bemegride and Amiphenazole". British Medical Journal. 2 (5042): 451-2. doi:10.1136 ... amiphenazole;[51] and a combination of bemegride, spironolactone, caffeine, pentylenetetrazol, strophanthin, penicillin and ...
more infohttps://en.m.wikipedia.org/wiki/Primidone

List Of Chemical AntidotesList Of Chemical Antidotes

Bemegride:. Bemegride (also known as Megimide) is a central Nervous System stimulant and antidote for barbiturate poisoning. ... usually in combination with bemegride, as well as poisoning from other sedative drugs and treatment of respiratory failure from ...
more infohttp://alchemy-and-alchemists.blogspot.com/2009/10/list-of-chemical-antidotes.html

Alchemy And Alchemists: 2009Alchemy And Alchemists: 2009

Bemegride:. Bemegride (also known as Megimide) is a central Nervous System stimulant and antidote for barbiturate poisoning. ... usually in combination with bemegride, as well as poisoning from other sedative drugs and treatment of respiratory failure from ...
more infohttp://alchemy-and-alchemists.blogspot.com/2009/?widgetType=BlogArchive&widgetId=BlogArchive1&action=toggle&dir=open&toggle=MONTHLY-1298966400000&toggleopen=MONTHLY-1259654400000
  • Long-term oral administration to the rat of barbitone, alone or together with the analeptics bemegride or pentylenetetrazol, show that the intensity of the withdrawal syndrome generally parallels the degree of associated CNS depression. (chemspider.com)
  • Bemegride has an antagonistic action on the GABAA receptor, suppressing both GABA- and pentobarbitone-evoked whole-cell currents to similar extents. (chemspider.com)