Rare chronic inflammatory disease involving the small blood vessels. It is of unknown etiology and characterized by mucocutaneous ulceration in the mouth and genital region and uveitis with hypopyon. The neuro-ocular form may cause blindness and death. SYNOVITIS; THROMBOPHLEBITIS; gastrointestinal ulcerations; RETINAL VASCULITIS; and OPTIC ATROPHY may occur as well.
An intermediate in the pathway of coenzyme A formation in mammalian liver and some microorganisms.
An erythematous eruption commonly associated with drug reactions or infection and characterized by inflammatory nodules that are usually tender, multiple, and bilateral. These nodules are located predominantly on the shins with less common occurrence on the thighs and forearms. They undergo characteristic color changes ending in temporary bruise-like areas. This condition usually subsides in 3-6 weeks without scarring or atrophy.
A characteristic symptom complex.
Study of stamps or postal markings. It usually refers to the design and commemorative aspects of the stamp.
Study of coins, tokens, medals, etc. However, it usually refers to medals pertaining to the history of medicine.
Inflammation of the EPIDIDYMIS. Its clinical features include enlarged epididymis, a swollen SCROTUM; PAIN; PYURIA; and FEVER. It is usually related to infections in the URINARY TRACT, which likely spread to the EPIDIDYMIS through either the VAS DEFERENS or the lymphatics of the SPERMATIC CORD.
The artery supplying nearly all the left half of the transverse colon, the whole of the descending colon, the sigmoid colon, and the greater part of the rectum. It is smaller than the superior mesenteric artery (MESENTERIC ARTERY, SUPERIOR) and arises from the aorta above its bifurcation into the common iliac arteries.
An eponym in the medical field is a term derived from the name of a person, often a physician or scientist, who is credited with discovering or describing a particular disease, condition, or procedure.
Skin diseases affecting or involving the cutaneous blood vessels and generally manifested as inflammation, swelling, erythema, or necrosis in the affected area.
Pathological outpouching or sac-like dilatation in the wall of any blood vessel (ARTERIES or VEINS) or the heart (HEART ANEURYSM). It indicates a thin and weakened area in the wall which may later rupture. Aneurysms are classified by location, etiology, or other characteristics.
A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*51 allele family.
Semisynthetic antibiotic prepared by combining the sodium salt of penicillin G with N,N'-dibenzylethylenediamine.
A condition characterized by the dilated tortuous veins of the SPERMATIC CORD with a marked left-sided predominance. Adverse effect on male fertility occurs when varicocele leads to an increased scrotal (and testicular) temperature and reduced testicular volume.
A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
A cluster of metabolic risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome X include excess ABDOMINAL FAT; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state. (from AHA/NHLBI/ADA Conference Proceedings, Circulation 2004; 109:551-556)

Autoantibodies to T cell costimulatory molecules in systemic autoimmune diseases. (1/725)

To determine whether antilymphocyte Abs to T cell costimulatory molecules are generated in patients with autoimmune diseases and, if they exist, to clarify the mechanism of their production and pathological roles, we investigated the presence of autoantibodies to CTLA-4 (CD152), CD28, B7-1 (CD80), and B7-2 (CD86) in serum samples obtained from patients with various autoimmune diseases and from normal subjects using recombinant fusion proteins. In ELISAs, anti-CD28, anti-B7-1, and anti-B7-2 Abs were rarely seen, whereas anti-CTLA-4 Abs were detected in 8.2% of the patients with systemic lupus erythematosus, 18.8% of those with rheumatoid arthritis, 3.1% of those with systemic sclerosis, 31.8% of those with Behcet's disease, 13.3% of those with Sjogren's syndrome, and 0% of healthy donors. This reactivity was confirmed by immunoblotting. More importantly, the purified anti-CTLA-4 Abs reacted with CTLA-4 expressed on P815 cells by flow cytometry. In addition, we found at least three epitopes on the CTLA-4 molecule. Furthermore, among the patients with Behcet's disease, uveitis was seen significantly less frequently in the anti-CTLA-4 Ab-positive patients. Taken collectively, these data indicate that anti-CTLA-4 autoantibodies are generated in systemic autoimmune diseases by an Ag-driven mechanism and may modulate the immune response in vivo by binding to CTLA-4 on T cells.  (+info)

The critical region for Behcet disease in the human major histocompatibility complex is reduced to a 46-kb segment centromeric of HLA-B, by association analysis using refined microsatellite mapping. (2/725)

The HLA-B51 allele is known to be associated with Behcet disease. Recently, we found a higher risk for Behcet disease in the MICA gene, 46 kb centromeric of HLA-B, by investigation of GCT repetitive polymorphism within exon 5 of MICA. The pathogenic gene causing Behcet disease, however, has remained uncertain. Here, eight polymorphic microsatellite markers, distributed over a 900-kb region surrounding the HLA-B locus, were subjected to association analysis for Behcet disease. Statistical studies of associated alleles detected on each microsatellite locus showed that the pathogenic gene for Behcet disease is most likely found within a 46-kb segment between the MICA and HLA-B genes. The results of this mapping study, and the results of an earlier study of ours, suggest that MICA is a strong candidate gene for the development of Behcet disease.  (+info)

Behcet's disease sera containing antiendothelial cell antibodies promote adhesion of T lymphocytes to cultured human dermal microvascular endothelial cells. (3/725)

Antiendothelial cell antibodies (AECA) have been detected in the sera of patients of autoimmune diseases showing vasculitis. Using IgM-ELISA, we found AECA in 42 (56%) of 75 sera samples from patients with Behcet's disease in a previous study. All of the 15 AECA-positive sera of Behcet's disease patients had an increased expression of the intercellular cell adhesion molecule-1 (ICAM-1), 93.3% of the sera induced the vascular cell adhesion molecule-1 (VCAM-1), and 100% of the serum induced the E-selectin molecule on human dermal microvascular endothelial cells (HDMEC). After stimulation of HDMEC with AECA-positive sera of Behcet's disease patients, the expression of ICAM-1 and VCAM-1 on HDMEC increased significantly at 4 hours, reaching a peak at 16 hours. Expression of E-selectin was induced at 1 hour after stimulation with a peak at 4 hours and it decreased thereafter. Adherence of T lymphocytes to HDMEC increased significantly after stimulation with AECA-positive sera from Behcet's disease patients. Also, the adherence of T lymphocytes to HDMEC increased at 4 hours and returned to its normal level at 48 hours. These results show that AECA-positive sera of Behcet's disease patients are capable of activating HDMEC to promote the adherence of T lymphocytes to increase the expression of ICAM-1, VCAM-1, and E-selectin on the cell surfaces. The whole process may play an important role in the pathogenesis of vasculitis in Behcet's disease.  (+info)

Childhood Behcet's disease: clinical features and comparison with adult-onset disease. (4/725)

OBJECTIVE: To study the clinical spectrum of Behcet's disease (BD) in childhood, in comparison to adult-onset disease. METHODS: Nineteen children, who fulfilled disease criteria up to the age of 16 yr, were studied. The results were compared to those of 34 adult patients with BD. An activity index and severity score were calculated for both study groups. RESULTS: The mean age of disease onset was 6.9+/-3.9 yr, similar ages of onset were found in males and females. The clinical spectrum of childhood BD resembled that of adult disease; however, the prevalence of certain manifestations was different between children and adults. Children with BD had significantly less genital ulcers, less vascular thromboses and more non-specific gastrointestinal symptoms, as well as central nervous system involvement and arthralgia. A relatively high prevalence of uveitis was found in childhood BD. The activity index and severity score were significantly lower in children than in adults. CONCLUSION: Our results point to a similar systemic expression of BD in children and adults; however, the disease seems to run a less severe course in children.  (+info)

Anti-Sa antibody in Chinese rheumatoid arthritis. (5/725)

OBJECTIVE: To test anti-Sa antibody in different autoimmune connective tissue diseases and analyze the relationship between Sa antibody and clinical manifestations and laboratory tests in rheumatoid arthritis. METHOD: Sa antigen was extracted from human placenta. Anti-Sa antibody was tested in 40 normal people and 478 connective tissue disease (CTD) patients using Western Blotting (WB). RESULTS: Sa antigen was a protein with molecular weights of 50 kD and 55 kD. Anti-Sa antibody was positive in 31.9% (61/191) rheumatoid arthritis (RA), 3.0% (2/67) Sjogren's syndrome (SS), 4.3% (2/46) systemic lupus erythmatosus (SLE) and 0% (0/66) Behcet's disease, 0% (0/60) polymyositis/dermatomyositis (PM/DM), 0% (0/66) other CTD and 0% (0/40) normal controls. Anti-Sa antibody was different from other auto-antibodies in RA. In rheumatoid arthritis its sensitivity, specificity, positive prediction rate, negative prediction rate were 31.9%, 98.6%, 93.8% and 68.5% respectively. Anti-Sa antibody positive patients were significantly different from anti-Sa antibody negative patients in moming stiffness, ESR, ANA and X-ray grade. CONCLUSION: Anti-Sa antibody was a new auto-antibody for the diagnosis of RA. Anti-Sa antibody positive patients seem to have more serious inflammation and more advanced disease process.  (+info)

Oligoclonal T cell expansions in patients with Behcet's disease. (6/725)

Behcet's disease (BD) is a multisystem disorder with oral and genital ulcers, mucocutaneous, ocular, joint, vascular and central nervous system involvement. In this study, the peripheral T cell repertoire was analysed in patients with BD with MoAbs against T cell receptor (TCR) Vbeta gene products in CD4+ and CD8+ T cell compartments, and these were compared with rheumatoid arthritis (RA) patients and healthy controls (HC). In the CD4+ T cell compartment, oligoclonal TCR Vbeta expression was observed in 56% of BD (10/18), 71% of RA (5/7) patients and 21% (3/14) of HC. In the CD8+ T cell group 50% of BD (9/18), 57% of RA patients and 28% of HC (4/14) had an oligoclonal TCR repertoire. An increase of TCR Vbeta5.1 subset was observed in five BD patients among CD8+ T cells. Other elevations of TCR Vbeta subsets were heterogeneously distributed with one to three different Vbeta subsets. Our results suggest an antigen-driven oligoclonal increase of T cells in BD. There was no overall increase in any Vbeta group to suggest a superantigen effect. Analysis of the responsible antigens causing the increase in T cell subsets may give insights into the aetiopathogenesis of BD and immunomodulation of these T cells may lead to new treatments.  (+info)

Neuro-Behcet's disease presenting with isolated unilateral lateral rectus muscle palsy. (7/725)

The authors present the clinical findings of a 30-year-old female and a 29-year-old male who both had isolated unilateral lateral rectus muscle palsy in neuro-Behcet's disease. The clinical feature related to isolated abduscens nerve palsy was identified by CT, systemic assessment and extraocular examination. These patients' constellation of findings appear to be unique: it does not follow any previously reported pattern of ocular manifestations of neuro-Behcet's disease.  (+info)

Association of MICA gene and HLA-B*5101 with Behcet's disease in Greece. (8/725)

PURPOSE: Behcet's disease (BD) is known to be associated with HLA-B51 in many different ethnic groups. Recently MICA, a member of a novel family of the human major histocompatibility complex (MHC) class I genes termed MIC (MHC class I chain-related genes), was identified near the HLA-B gene, and a triplet repeat microsatellite polymorphism was found in the transmembrane (TM) region. Because a strong association with BD of one particular MICA-TM allele, A6, was shown in a Japanese population, the present study was conducted to investigate microsatellite polymorphism in Greek patients with BD to know whether this association is generally observed in BD occurring in other populations. METHODS: Thirty-eight Greek patients with BD and 40 ethnically matched control subjects were examined for MICA microsatellite polymorphism using polymerase chain reaction (PCR) and subsequent automated fragment detection by fluorescent-based technology. RESULTS: Similar to the Japanese patients with BD, the phenotype frequency of the MICA-TM A6 allele was significantly increased in the Greek patients with BD (50.0% in control subjects versus 86.8% in BD cases), with an odds ratio (OR) of 6.60 (P = 0.0012). The MICA-A6 allele was found in a high frequency both in males and females (weighted OR = 6.68; P = 0.0017). No association was found between the A6 allele and several disease features. A strong association exists between the MICA-TM A6 allele and the B*5101 allele in both the control subjects and patients with BD (weighted OR = 44.39; P = 0.0000023). CONCLUSIONS: This study revealed in Greek patients a strong association of BD with a particular MICA-TM allele, MICA-A6, providing insight into the molecular mechanism underlying the development of BD.  (+info)

Behcet's syndrome, also known as Behcet's disease, is a rare, chronic, and systemic inflammatory disorder that affects multiple organs and systems in the body. It is characterized by recurrent episodes of oral and genital ulcers, as well as inflammation of the eyes, skin, joints, and blood vessels. The exact cause of Behcet's syndrome is unknown, but it is thought to be an autoimmune disorder in which the immune system attacks healthy cells and tissues in the body. The symptoms of Behcet's syndrome can vary widely from person to person, and the severity of the disease can also vary over time. Treatment for Behcet's syndrome typically involves a combination of medications, including corticosteroids, immunosuppressants, and biologic agents, to reduce inflammation and prevent complications. In some cases, surgery may be necessary to treat complications such as eye damage or blood vessel inflammation.

Pantetheine is a compound that is naturally found in many foods, including meat, poultry, fish, and eggs. It is also available as a dietary supplement. In the medical field, pantetheine is used to treat a variety of conditions, including liver disease, heart disease, and high blood pressure. It is also used to improve the function of the immune system and to help prevent the development of certain types of cancer. Pantetheine is thought to work by increasing the production of certain enzymes in the body, which can help to improve the function of the liver and other organs. It is important to note that more research is needed to fully understand the effects of pantetheine on the human body and to determine the optimal dosage for different conditions.

Erythema nodosum is a skin condition characterized by the appearance of red, painful, and tender nodules or bumps on the shins, ankles, and feet. It is usually associated with an underlying inflammatory condition, such as sarcoidosis, inflammatory bowel disease, or certain infections, including tuberculosis and streptococcal infections. Erythema nodosum can also be caused by certain medications, including antibiotics, nonsteroidal anti-inflammatory drugs (NSAIDs), and oral contraceptives. The condition is self-limiting, meaning it will resolve on its own within a few weeks to a few months, although it may recur in some cases. Treatment is typically focused on managing the underlying cause and relieving symptoms, such as pain and inflammation.

In the medical field, a syndrome is a set of symptoms and signs that occur together and suggest the presence of a particular disease or condition. A syndrome is often defined by a specific pattern of symptoms that are not caused by a single underlying disease, but rather by a combination of factors, such as genetic, environmental, or hormonal. For example, Down syndrome is a genetic disorder that is characterized by a specific set of physical and intellectual characteristics, such as a flattened facial profile, short stature, and intellectual disability. Similarly, the flu syndrome is a set of symptoms that occur together, such as fever, cough, sore throat, and body aches, that suggest the presence of an influenza virus infection. Diagnosing a syndrome involves identifying the specific set of symptoms and signs that are present, as well as ruling out other possible causes of those symptoms. Once a syndrome is diagnosed, it can help guide treatment and management of the underlying condition.

Epididymitis is an inflammation of the epididymis, which is a coiled tube located at the back of the testicle that is responsible for storing and transporting sperm. It is usually caused by a bacterial infection, but can also be caused by other factors such as sexually transmitted infections, physical trauma, or certain medical conditions. Symptoms of epididymitis may include pain or swelling in the testicle or scrotum, difficulty urinating, fever, chills, and body aches. If left untreated, epididymitis can lead to complications such as infertility, chronic pain, and the spread of infection to other parts of the body. Diagnosis of epididymitis typically involves a physical examination, medical history, and laboratory tests such as a urine analysis or blood test. Treatment typically involves antibiotics to treat the underlying infection, as well as pain relief medication and rest. In some cases, surgery may be necessary to remove damaged tissue or drain an abscess.

Skin diseases, vascular refers to a group of medical conditions that affect the blood vessels in the skin. These conditions can cause a range of symptoms, including redness, swelling, itching, pain, and changes in skin color or texture. Some common examples of skin diseases that affect the blood vessels include: 1. Vasculitis: This is a condition in which the blood vessels become inflamed, leading to symptoms such as redness, swelling, and pain. 2. Angioedema: This is a condition in which the blood vessels under the skin become swollen, leading to hives or swelling in the face, lips, tongue, or throat. 3. Telangiectasia: This is a condition in which small, dilated blood vessels appear on the surface of the skin, often on the face. 4. Purpura: This is a condition in which small blood vessels in the skin break down, leading to the appearance of purple or red spots on the skin. 5. Raynaud's phenomenon: This is a condition in which the blood vessels in the fingers and toes constrict, leading to coldness, numbness, and sometimes pain or discoloration of the skin. Treatment for skin diseases that affect the blood vessels will depend on the specific condition and its severity. In some cases, medications may be used to reduce inflammation or improve blood flow. In other cases, lifestyle changes or surgery may be necessary. It is important to consult with a healthcare professional for proper diagnosis and treatment.

An aneurysm is a bulge or dilation in the wall of a blood vessel, typically a artery. It occurs when the weakened wall of the vessel balloons out and becomes distended, creating a sac-like structure. Aneurysms can occur in any part of the body, but they are most commonly found in the brain, aorta, and legs. Aneurysms can be caused by a variety of factors, including high blood pressure, atherosclerosis (hardening of the arteries), trauma, and genetic predisposition. They can also be caused by certain medical conditions, such as Marfan syndrome or Ehlers-Danlos syndrome. Aneurysms can be asymptomatic, meaning they do not cause any symptoms, or they can cause symptoms such as headache, neck pain, visual changes, or weakness or numbness in the extremities. If an aneurysm ruptures, it can cause a life-threatening bleeding episode. Treatment for aneurysms depends on the size, location, and risk of rupture. Small aneurysms may be monitored with regular imaging studies, while larger aneurysms or those at high risk of rupture may require surgical repair or endovascular coiling, a minimally invasive procedure in which a catheter is inserted into the aneurysm and a coil is placed to fill the sac and prevent further expansion.

HLA-B51 is a specific type of human leukocyte antigen (HLA) protein that is found on the surface of cells in the immune system. HLA proteins play a crucial role in the immune system by helping to identify and target foreign substances, such as viruses and bacteria, for destruction. HLA-B51 is a relatively rare HLA antigen, and it is associated with an increased risk of developing certain autoimmune diseases, such as pemphigus vulgaris and Behçet's disease. In addition, HLA-B51 has been linked to an increased risk of developing certain types of cancer, including non-Hodgkin lymphoma and squamous cell carcinoma. HLA-B51 is typically identified through blood tests and is often used as a diagnostic marker for certain autoimmune diseases and cancers. It is also sometimes used as a prognostic marker, as the presence of HLA-B51 may be associated with a worse outcome for certain conditions.

Penicillin G Benzathine is a long-acting form of penicillin that is used to treat bacterial infections. It is a semisynthetic derivative of penicillin G, which is a type of penicillin antibiotic. Penicillin G Benzathine is administered as an injection and is typically used to treat infections that are caused by bacteria that are resistant to other antibiotics. It is also used to prevent certain types of bacterial infections, such as syphilis and anthrax. Penicillin G Benzathine is generally well-tolerated, but it can cause side effects such as pain, redness, and swelling at the injection site. It is important to note that penicillin G Benzathine is not effective against viral infections and should not be used to treat infections caused by viruses.

Varicocele is a medical condition in which the veins in the scrotum become enlarged and twisted, usually due to a blockage or weakness in the valves that control blood flow. This can lead to a buildup of blood in the veins, causing them to become engorged and twisted. Varicocele is most commonly seen in men, and it is often associated with infertility. It is typically diagnosed through a physical examination and imaging tests such as ultrasound. Treatment options for varicocele may include medication, surgery, or other procedures to improve blood flow and reduce swelling.

Down syndrome, also known as trisomy 21, is a genetic disorder caused by the presence of an extra copy of chromosome 21. This extra genetic material affects the development and function of the body, leading to a range of physical, cognitive, and medical characteristics. Individuals with Down syndrome typically have distinct facial features, such as a flattened face, small ears, and a short neck. They may also have intellectual disabilities, ranging from mild to moderate, and may experience delays in speech and language development. Other common features include an increased risk of certain medical conditions, such as heart defects, respiratory problems, and hearing loss. Down syndrome is caused by a random event during the formation of reproductive cells, and the risk of having a child with the condition increases with the age of the mother. There is currently no cure for Down syndrome, but early intervention and support can help individuals with the condition to reach their full potential and lead fulfilling lives.

Metabolic Syndrome X, also known as Syndrome X or Insulin Resistance Syndrome, is a cluster of conditions that increase the risk of developing heart disease, stroke, and type 2 diabetes. The five key components of Metabolic Syndrome X are: 1. Abdominal obesity: A waist circumference of 102 cm (40 inches) or more in men and 88 cm (35 inches) or more in women. 2. High blood pressure: A systolic blood pressure of 130 mmHg or higher, or a diastolic blood pressure of 85 mmHg or higher. 3. High fasting blood sugar: A fasting blood sugar level of 100 mg/dL or higher. 4. High triglyceride levels: A triglyceride level of 150 mg/dL or higher. 5. Low HDL cholesterol levels: An HDL cholesterol level of less than 40 mg/dL in men and less than 50 mg/dL in women. These conditions are often found together and can be caused by a variety of factors, including genetics, lifestyle, and certain medical conditions. Treatment for Metabolic Syndrome X typically involves lifestyle changes, such as diet and exercise, and may also include medication to manage blood pressure, blood sugar, and cholesterol levels.

Behcets syndrome (or disease) causes inflammation of the blood vessels and symptoms in many parts of the body. Learn about ... Behcets syndrome is a disease that involves vasculitis, which is inflammation of the blood vessels. It causes problems in many ... Behcets Disease (Johns Hopkins Vasculitis Center) * Behcets Disease (Mayo Foundation for Medical Education and Research) Also ... The primary NIH organization for research on Behcets Syndrome is the National Human Genome Research Institute ...
The Behcets Syndrome International Study Group Criteria calculator is created by QxMD. ... The Behcets Syndrome International Study Group Criteria calculator is created by QxMD. ... Behcets disease is an uncommon inflammatory disease for which there are several proposed diagnostic criteria. At the time of ... Behcets disease is an uncommon inflammatory disease for which there are several proposed diagnostic criteria. At the time of ...
Hippocrates may have described Behçet disease in the fifth century BCE; however, the first description of the syndrome was ... Clinical and Ultrasonographic Evaluation of Lower-extremity Vein Thrombosis in Behcet Syndrome: An Observational Study. ... encoded search term (Behcet Disease) and Behcet Disease What to Read Next on Medscape ... Apremilast for Behçets syndrome--a phase 2, placebo-controlled study. N Engl J Med. 2015 Apr 16. 372 (16):1510-8. [QxMD ...
Fever is taken to be rare in Behcets syndrome (BS) and when present it is usually considered to be associated with vascular ...
The syndrome carries the name of the Turkish dermatologist Hulusi Behçet, who, in 1937, described a syndrome of recurrent ... Behçet syndrome is a multisystem disease of unknown etiology probably first described by Hippocrates in the 5th century. ... encoded search term (Behcet Syndrome) and Behcet Syndrome What to Read Next on Medscape ... Genetic anticipation in Behcets syndrome. Ann Rheum Dis. 1998 Jan. 57(1):45-8. [QxMD MEDLINE Link]. ...
Hippocrates may have described Behçet disease in the fifth century BCE; however, the first description of the syndrome was ... Clinical and Ultrasonographic Evaluation of Lower-extremity Vein Thrombosis in Behcet Syndrome: An Observational Study. ... encoded search term (Behcet Disease) and Behcet Disease What to Read Next on Medscape ... Apremilast for Behçets syndrome--a phase 2, placebo-controlled study. N Engl J Med. 2015 Apr 16. 372 (16):1510-8. [QxMD ...
For three separate autoimmune events (Behcets syndrome, Raynauds disease, and type 1 diabetes), statistically significant ... Abbreviations: FDA = Food and Drug Administration; GBS = Guillain-Barré syndrome; HPV = human papillomavirus; HPV4 = ... statistically significant increased risks were observed for any of the prespecified endpoints including Guillain-Barré syndrome ...
Did you get a pustule at your blood draw site? Consider Behcets Syndrome. The original description of Behçets syndrome ...
Patient experience of genitourinary syndrome of menopause. Take Quiz. Symptoms of genitourinary syndrome of menopause. Take ... Behcets syndrome: Types of manifestations. Take Quiz. Pain/Pain Relief. Quiz Updated Opioid Prescribing Guidelines. Take Quiz ... Hepatopulmonary syndrome symptoms. Take Quiz. USPSTF recommendations: Screening for celiac disease in asymptomatic persons. ...
Juvenile Idiopathic Arthritis, Lupus, dermatomyositis, periodic fever syndromes, scleroderma, Behcets disease and vasculitis, ...
Vascular endothelial growth factor levels are increased and associated with disease activity in patients with Behcets syndrome ...
Small vessel - This includes Behcets syndrome, granulomatosis with polyangiitis, Churg-Strauss syndrome, cutaneous vasculitis ...
Lung Diseases/epidemiology, Lung Diseases/etiology, Behcet Syndrome/epidemiology, Chemical Warfare Agents/adverse effects, ...
Sjoegrens syndrome (SS), and Adamantiades-Behcet disease (BD). An acute isolated neurological syndrome presents the biggest ...
... and Behcets syndrome [103]. Taking into consideration that a general increase in cAMP might also support detrimental effects ... Despite clinical similarities there are significant differences between acute limb trauma and complex regional pain syndrome I ... findings have also been discussed in the context of understanding clinical entities like the complex regional pain syndrome ( ...
Behcets syndrome, Langerhans cell histiocytosis, and graft vs. host disease, due to its potent anti-inflammatory properties.3 ... and Wernicke-Korsakoff Syndrome. On physical exam, his left leg is erythematous and edematous, and he has decreased sensitivity ...
Assessment of Damage in Behcets Disease: Do We Need a Specific Damage Index?. Ali Ugur Unal1, Hale Gulcin Yildirim2, Ceylan ... Background/Purpose: Behcets Disease (BD) is a systemic vasculitis characterized by involvement of vessels of any size and type ... Unal AU, Yildirim HG, Cikikci C, Ozen G, Inanc N, Atagunduz P, Ergun T, Direskeneli H. Assessment of Damage in Behcets Disease ... This modified VDI (Behcets Disease-VDI [B-VDI]) was also scored in allpatients. ...
NIH researchers identify new gene variants associated with risk for complex inflammatory syndrome. ... NIH researchers identify new gene variants associated with risk for complex inflammatory syndrome. ... About 1 in 250 people in Turkey have Behcets disease; others with the disease are found largely in regions along the Silk Road ... From nearly 800,000 SNPs, researchers detected and mapped a small number that are found in those who have Behcets disease at a ...
Optimization of Adalimumab on Refractory Uveitis of Behcet´s Syndrome. Multicenter Study of 23 Patients - Comunicación a ... Biological treatments in primary sjögren syndrome - Comunicación a Congreso * EULAR Primary SjöGren?s Syndrome Disease Activity ... Epidemiology of behcets disease in northern Spain - Comunicación a Congreso * Increase of serum endothelin-1 levels in ... Microvascular involvement in behcets disease: study of nailfold capillaroscopy in patients from a national referral center - ...
... leaky gut syndrome (unhealthy intestinal cells), and viruses (such as Epstein Barr Virus) can all trigger autoimmunity. Some ...
  • Leccese P, Yazici Y, Olivieri I. Behcet's syndrome in nonendemic regions. (medscape.com)
  • Fatigue in patients with Behcet's syndrome: relationship with quality of life, depression, anxiety, disability and disease activity. (medscape.com)
  • Factor V Leiden and venous thrombosis in a 4-yr-old girl with Behcet's syndrome. (medscape.com)
  • Genetic anticipation in Behcet's syndrome. (medscape.com)
  • Kikuchi H, Aramaki K, Hirohata S. Effect of infliximab in progressive neuro-Behcet's syndrome. (medscape.com)
  • Behcet's syndrome is a disease that involves vasculitis , which is inflammation of the blood vessels. (medlineplus.gov)
  • The Behcet's Syndrome International Study Group Criteria calculator is created by QxMD. (medscape.com)
  • 13. [Neuro-Behcet's syndrome]. (nih.gov)
  • Behcet's (beh-CHETS) disease, also called Behcet's syndrome, is a rare disorder that causes blood vessel inflammation throughout your body . (mayoclinic.org)
  • 5. Behcet's disease complicated with myelodysplastic syndrome: a report of two cases and review of the literature. (nih.gov)
  • Only three of these showed up at a higher rate among the vaccinated girls - the autoimmune conditions Behcet's syndrome, Raynaud's disease and type 1 diabetes . (rxwiki.com)
  • Although the patient had Behcet's disease (BD)-like symptoms, pancytopenia could not be explained by the diagnosis, prompting a bone marrow biopsy which showed myelodysplastic syndrome. (elsevierpure.com)
  • Buyuktas D, Hatemi G, Yuksel-Findikoglu S, Ugurlu S, Yazici H, Yurdakul S. Fatigue is correlated with disease activity but not with the type of organ involvement in Behçet's syndrome: a comparative clinical survey. (medscape.com)
  • Uveitis associated with pediatric Behcet disease in the american midwest. (medscape.com)
  • Neuropsychological follow-up of 12 patients with neuro-Behcet disease. (medscape.com)
  • 3 out of 7 Behçet's syndrome patients with pulmonary vascular disease were diagnosed as PE in Shanghai Pulmonary Hospital from 2009 to 2016. (medscape.com)
  • 20. Neuro-Behçet's syndrome in a patient not fulfilling criteria for Behçet's disease: clinical features and value of brain imaging. (nih.gov)
  • 2. High Incidence of Gastrointestinal Ulceration and Cytogenetic Aberration of Trisomy 8 as Typical Features of Behçet's Disease Associated with Myelodysplastic Syndrome: A Series of 16 Consecutive Chinese Patients from the Shanghai Behçet's Disease Database and Comparison with the Literature. (nih.gov)
  • 6. Large-vessel thrombosis in intestinal Behçet's disease complicated with myelodysplastic syndrome and trisomy 8. (nih.gov)
  • 7. A reappraisal of the association between Behçet's disease, myelodysplastic syndrome and the presence of trisomy 8: a systematic literature review. (nih.gov)
  • 9. Behçet's disease-like symptoms associated with myelodysplastic syndrome with trisomy 8: a case report and review of the literature. (nih.gov)
  • 10. Long-term maintenance of the mucosal healing induced by azacitidine therapy in a patient with intestinal Behçet's-like disease accompanied with myelodysplastic syndrome involving trisomy 8. (nih.gov)
  • 11. Allogeneic stem cell transplantation for trisomy 8-positive myelodysplastic syndrome or myelodysplastic/myeloproliferative disease with refractory Behçet's disease: Case report and the review of literature. (nih.gov)
  • 13. A case of Behçet's-like disease associated with trisomy 8-positive myelodysplastic syndrome carrying MEFV E148Q variant presented with periodic fever. (nih.gov)
  • 14. Intestinal Behçet's disease associated with myelodysplastic syndrome with chromosomal trisomy 8--a report of two cases and a review of the literature. (nih.gov)
  • 15. Clinical Features of Intestinal Behçet's Disease Associated with Myelodysplastic Syndrome and Trisomy 8. (nih.gov)
  • Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease. (lookformedical.com)
  • 4. [Behçet's-like syndrome and other dysimmunitary manifestations related to myelodysplastic syndromes with trisomy 8]. (nih.gov)
  • 12. Trisomy 8 involved in myelodysplastic syndromes as a risk factor for intestinal ulcers and thrombosis--Behçet's syndrome. (nih.gov)
  • Behçet's syndrome is a type of systemic chronic vasculitis of unknown etiology, frequently characterized by recurrent oral and genital ulcers and uveitis. (medscape.com)
  • Cardiac thrombosis as a manifestation of Behçet syndrome. (medscape.com)
  • Seyahi E, Yurdakul S. Behçet's Syndrome and Thrombosis. (medscape.com)
  • Furthermore, although deep venous thrombosis has high incidence in Behçet's syndrome patients, pulmonary artery thrombosis is an uncommon complication. (medscape.com)
  • Combining the findings of this and previous case reports of pulmonary artery thrombosis in Behçet's syndrome patients, we sought to determine the best treatment options for pulmonary artery thrombosis in Behçet's syndrome patients. (medscape.com)
  • After excluding common infectious diseases such as tuberculosis and brucellosis, a diagnosis of Behçet's syndrome with pulmonary artery thrombosis was made. (medscape.com)
  • Behçet's syndrome affects various sizes of vessels by perivascular infiltration and vasculitis. (medscape.com)
  • Unlike other classic types of vasculitis, Behçet's syndrome patients can present with both arterial and venous involvement. (medscape.com)
  • NIH researchers identify new gene variants associated with risk for complex inflammatory syndrome. (nih.gov)
  • Although vascular Behçet's syndrome is found in only around 15% of Behçet's syndrome patients, it is the major cause of morbidity and mortality among them. (medscape.com)
  • Vascular involvement in Behçet's syndrome is a major contributor to morbidity and mortality of Behçet's syndrome patients. (medscape.com)
  • Consequently, early detection of vascular involvement has a major impact on the prognosis of patients with Behçet's syndrome. (medscape.com)
  • Cette collaboration permet une prise en charge optimisée pour les patients atteints de maladies rares du foie, tout en privilégiant toujours une prise en charge locale dans le bassin de vie du patient. (aphp.fr)
  • Ces centres sont officiellement labellisés par le ministère de la Santé dans le cadre des plans nationaux maladies rares qui ont pour objectif de structurer pour les maladies rares une offre de soins de haut niveau et d'améliorer la visibilité du dispositif ainsi mis en place aussi bien pour les patients que pour les professionnels de santé. (aphp.fr)
  • 6. Cerebrospinal fluid interleukin-6 in progressive Neuro-Behçet's syndrome. (nih.gov)
  • Behçet's syndrome: one year in review 2022. (nih.gov)