Behcet Syndrome
Rare chronic inflammatory disease involving the small blood vessels. It is of unknown etiology and characterized by mucocutaneous ulceration in the mouth and genital region and uveitis with hypopyon. The neuro-ocular form may cause blindness and death. SYNOVITIS; THROMBOPHLEBITIS; gastrointestinal ulcerations; RETINAL VASCULITIS; and OPTIC ATROPHY may occur as well.
Panniculitis, Nodular Nonsuppurative
A form of panniculitis characterized by recurrent episodes of fever accompanied by the eruption of single or multiple erythematous subcutaneous nodules on the lower extremities. They normally resolve, but tend to leave depressions in the skin. The condition is most often seen in women, alone or in association with other disorders.
Erythema Nodosum
An erythematous eruption commonly associated with drug reactions or infection and characterized by inflammatory nodules that are usually tender, multiple, and bilateral. These nodules are located predominantly on the shins with less common occurrence on the thighs and forearms. They undergo characteristic color changes ending in temporary bruise-like areas. This condition usually subsides in 3-6 weeks without scarring or atrophy.
Philately
Numismatics
Epididymitis
Mesenteric Artery, Inferior
The artery supplying nearly all the left half of the transverse colon, the whole of the descending colon, the sigmoid colon, and the greater part of the rectum. It is smaller than the superior mesenteric artery (MESENTERIC ARTERY, SUPERIOR) and arises from the aorta above its bifurcation into the common iliac arteries.
Skin Diseases, Vascular
Aneurysm
HLA-B51 Antigen
Penicillin G Benzathine
Varicocele
Down Syndrome
A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
Metabolic Syndrome X
A cluster of metabolic risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome X include excess ABDOMINAL FAT; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state. (from AHA/NHLBI/ADA Conference Proceedings, Circulation 2004; 109:551-556)
Stomatitis, Aphthous
A recurrent disease of the oral mucosa of unknown etiology. It is characterized by small white ulcerative lesions, single or multiple, round or oval. Two to eight crops of lesions occur per year, lasting for 7 to 14 days and then heal without scarring. (From Jablonski's Dictionary of Dentistry, 1992, p742)
Ulcer
Oral Ulcer
A loss of mucous substance of the mouth showing local excavation of the surface, resulting from the sloughing of inflammatory necrotic tissue. It is the result of a variety of causes, e.g., denture irritation, aphthous stomatitis (STOMATITIS, APHTHOUS); NOMA; necrotizing gingivitis (GINGIVITIS, NECROTIZING ULCERATIVE); TOOTHBRUSHING; and various irritants. (From Jablonski, Dictionary of Dentistry, 1992, p842)
HLA-B52 Antigen
Click Chemistry
Organic chemistry methodology that mimics the modular nature of various biosynthetic processes. It uses highly reliable and selective reactions designed to "click" i.e., rapidly join small modular units together in high yield, without offensive byproducts. In combination with COMBINATORIAL CHEMISTRY TECHNIQUES, it is used for the synthesis of new compounds and combinatorial libraries.
Calcium-Calmodulin-Dependent Protein Kinases
A CALMODULIN-dependent enzyme that catalyzes the phosphorylation of proteins. This enzyme is also sometimes dependent on CALCIUM. A wide range of proteins can act as acceptor, including VIMENTIN; SYNAPSINS; GLYCOGEN SYNTHASE; MYOSIN LIGHT CHAINS; and the MICROTUBULE-ASSOCIATED PROTEINS. (From Enzyme Nomenclature, 1992, p277)
Treatment Outcome
Microtubule-Associated Proteins
Arthropathy, Neurogenic
Chronic progressive degeneration of the stress-bearing portion of a joint, with bizarre hypertrophic changes at the periphery. It is probably a complication of a variety of neurologic disorders, particularly TABES DORSALIS, involving loss of sensation, which leads to relaxation of supporting structures and chronic instability of the joint. (Dorland, 27th ed)
Ankle Joint
Annual Reports as Topic
Californium
Demyelinating Diseases
Demyelinating Autoimmune Diseases, CNS
Theilovirus
Brugada Syndrome
An autosomal dominant defect of cardiac conduction that is characterized by an abnormal ST-segment in leads V1-V3 on the ELECTROCARDIOGRAM resembling a right BUNDLE-BRANCH BLOCK; high risk of VENTRICULAR TACHYCARDIA; or VENTRICULAR FIBRILLATION; SYNCOPAL EPISODE; and possible sudden death. This syndrome is linked to mutations of gene encoding the cardiac SODIUM CHANNEL alpha subunit.
Rosacea
A cutaneous disorder primarily of convexities of the central part of the FACE, such as FOREHEAD; CHEEK; NOSE; and CHIN. It is characterized by FLUSHING; ERYTHEMA; EDEMA; RHINOPHYMA; papules; and ocular symptoms. It may occur at any age but typically after age 30. There are various subtypes of rosacea: erythematotelangiectatic, papulopustular, phymatous, and ocular (National Rosacea Society's Expert Committee on the Classification and Staging of Rosacea, J Am Acad Dermatol 2002; 46:584-7).
Drug Eruptions
Musculoskeletal Diseases
Inflammation
Panuveitis
Inflammation in which both the anterior and posterior segments of the uvea are involved and a specific focus is not apparent. It is often severe and extensive and a serious threat to vision. Causes include systemic diseases such as tuberculosis, sarcoidosis, and syphilis, as well as malignancies. The intermediate segment of the eye is not involved.
Autoantibodies to T cell costimulatory molecules in systemic autoimmune diseases. (1/725)
To determine whether antilymphocyte Abs to T cell costimulatory molecules are generated in patients with autoimmune diseases and, if they exist, to clarify the mechanism of their production and pathological roles, we investigated the presence of autoantibodies to CTLA-4 (CD152), CD28, B7-1 (CD80), and B7-2 (CD86) in serum samples obtained from patients with various autoimmune diseases and from normal subjects using recombinant fusion proteins. In ELISAs, anti-CD28, anti-B7-1, and anti-B7-2 Abs were rarely seen, whereas anti-CTLA-4 Abs were detected in 8.2% of the patients with systemic lupus erythematosus, 18.8% of those with rheumatoid arthritis, 3.1% of those with systemic sclerosis, 31.8% of those with Behcet's disease, 13.3% of those with Sjogren's syndrome, and 0% of healthy donors. This reactivity was confirmed by immunoblotting. More importantly, the purified anti-CTLA-4 Abs reacted with CTLA-4 expressed on P815 cells by flow cytometry. In addition, we found at least three epitopes on the CTLA-4 molecule. Furthermore, among the patients with Behcet's disease, uveitis was seen significantly less frequently in the anti-CTLA-4 Ab-positive patients. Taken collectively, these data indicate that anti-CTLA-4 autoantibodies are generated in systemic autoimmune diseases by an Ag-driven mechanism and may modulate the immune response in vivo by binding to CTLA-4 on T cells. (+info)The critical region for Behcet disease in the human major histocompatibility complex is reduced to a 46-kb segment centromeric of HLA-B, by association analysis using refined microsatellite mapping. (2/725)
The HLA-B51 allele is known to be associated with Behcet disease. Recently, we found a higher risk for Behcet disease in the MICA gene, 46 kb centromeric of HLA-B, by investigation of GCT repetitive polymorphism within exon 5 of MICA. The pathogenic gene causing Behcet disease, however, has remained uncertain. Here, eight polymorphic microsatellite markers, distributed over a 900-kb region surrounding the HLA-B locus, were subjected to association analysis for Behcet disease. Statistical studies of associated alleles detected on each microsatellite locus showed that the pathogenic gene for Behcet disease is most likely found within a 46-kb segment between the MICA and HLA-B genes. The results of this mapping study, and the results of an earlier study of ours, suggest that MICA is a strong candidate gene for the development of Behcet disease. (+info)Behcet's disease sera containing antiendothelial cell antibodies promote adhesion of T lymphocytes to cultured human dermal microvascular endothelial cells. (3/725)
Antiendothelial cell antibodies (AECA) have been detected in the sera of patients of autoimmune diseases showing vasculitis. Using IgM-ELISA, we found AECA in 42 (56%) of 75 sera samples from patients with Behcet's disease in a previous study. All of the 15 AECA-positive sera of Behcet's disease patients had an increased expression of the intercellular cell adhesion molecule-1 (ICAM-1), 93.3% of the sera induced the vascular cell adhesion molecule-1 (VCAM-1), and 100% of the serum induced the E-selectin molecule on human dermal microvascular endothelial cells (HDMEC). After stimulation of HDMEC with AECA-positive sera of Behcet's disease patients, the expression of ICAM-1 and VCAM-1 on HDMEC increased significantly at 4 hours, reaching a peak at 16 hours. Expression of E-selectin was induced at 1 hour after stimulation with a peak at 4 hours and it decreased thereafter. Adherence of T lymphocytes to HDMEC increased significantly after stimulation with AECA-positive sera from Behcet's disease patients. Also, the adherence of T lymphocytes to HDMEC increased at 4 hours and returned to its normal level at 48 hours. These results show that AECA-positive sera of Behcet's disease patients are capable of activating HDMEC to promote the adherence of T lymphocytes to increase the expression of ICAM-1, VCAM-1, and E-selectin on the cell surfaces. The whole process may play an important role in the pathogenesis of vasculitis in Behcet's disease. (+info)Childhood Behcet's disease: clinical features and comparison with adult-onset disease. (4/725)
OBJECTIVE: To study the clinical spectrum of Behcet's disease (BD) in childhood, in comparison to adult-onset disease. METHODS: Nineteen children, who fulfilled disease criteria up to the age of 16 yr, were studied. The results were compared to those of 34 adult patients with BD. An activity index and severity score were calculated for both study groups. RESULTS: The mean age of disease onset was 6.9+/-3.9 yr, similar ages of onset were found in males and females. The clinical spectrum of childhood BD resembled that of adult disease; however, the prevalence of certain manifestations was different between children and adults. Children with BD had significantly less genital ulcers, less vascular thromboses and more non-specific gastrointestinal symptoms, as well as central nervous system involvement and arthralgia. A relatively high prevalence of uveitis was found in childhood BD. The activity index and severity score were significantly lower in children than in adults. CONCLUSION: Our results point to a similar systemic expression of BD in children and adults; however, the disease seems to run a less severe course in children. (+info)Anti-Sa antibody in Chinese rheumatoid arthritis. (5/725)
OBJECTIVE: To test anti-Sa antibody in different autoimmune connective tissue diseases and analyze the relationship between Sa antibody and clinical manifestations and laboratory tests in rheumatoid arthritis. METHOD: Sa antigen was extracted from human placenta. Anti-Sa antibody was tested in 40 normal people and 478 connective tissue disease (CTD) patients using Western Blotting (WB). RESULTS: Sa antigen was a protein with molecular weights of 50 kD and 55 kD. Anti-Sa antibody was positive in 31.9% (61/191) rheumatoid arthritis (RA), 3.0% (2/67) Sjogren's syndrome (SS), 4.3% (2/46) systemic lupus erythmatosus (SLE) and 0% (0/66) Behcet's disease, 0% (0/60) polymyositis/dermatomyositis (PM/DM), 0% (0/66) other CTD and 0% (0/40) normal controls. Anti-Sa antibody was different from other auto-antibodies in RA. In rheumatoid arthritis its sensitivity, specificity, positive prediction rate, negative prediction rate were 31.9%, 98.6%, 93.8% and 68.5% respectively. Anti-Sa antibody positive patients were significantly different from anti-Sa antibody negative patients in moming stiffness, ESR, ANA and X-ray grade. CONCLUSION: Anti-Sa antibody was a new auto-antibody for the diagnosis of RA. Anti-Sa antibody positive patients seem to have more serious inflammation and more advanced disease process. (+info)Oligoclonal T cell expansions in patients with Behcet's disease. (6/725)
Behcet's disease (BD) is a multisystem disorder with oral and genital ulcers, mucocutaneous, ocular, joint, vascular and central nervous system involvement. In this study, the peripheral T cell repertoire was analysed in patients with BD with MoAbs against T cell receptor (TCR) Vbeta gene products in CD4+ and CD8+ T cell compartments, and these were compared with rheumatoid arthritis (RA) patients and healthy controls (HC). In the CD4+ T cell compartment, oligoclonal TCR Vbeta expression was observed in 56% of BD (10/18), 71% of RA (5/7) patients and 21% (3/14) of HC. In the CD8+ T cell group 50% of BD (9/18), 57% of RA patients and 28% of HC (4/14) had an oligoclonal TCR repertoire. An increase of TCR Vbeta5.1 subset was observed in five BD patients among CD8+ T cells. Other elevations of TCR Vbeta subsets were heterogeneously distributed with one to three different Vbeta subsets. Our results suggest an antigen-driven oligoclonal increase of T cells in BD. There was no overall increase in any Vbeta group to suggest a superantigen effect. Analysis of the responsible antigens causing the increase in T cell subsets may give insights into the aetiopathogenesis of BD and immunomodulation of these T cells may lead to new treatments. (+info)Neuro-Behcet's disease presenting with isolated unilateral lateral rectus muscle palsy. (7/725)
The authors present the clinical findings of a 30-year-old female and a 29-year-old male who both had isolated unilateral lateral rectus muscle palsy in neuro-Behcet's disease. The clinical feature related to isolated abduscens nerve palsy was identified by CT, systemic assessment and extraocular examination. These patients' constellation of findings appear to be unique: it does not follow any previously reported pattern of ocular manifestations of neuro-Behcet's disease. (+info)Association of MICA gene and HLA-B*5101 with Behcet's disease in Greece. (8/725)
PURPOSE: Behcet's disease (BD) is known to be associated with HLA-B51 in many different ethnic groups. Recently MICA, a member of a novel family of the human major histocompatibility complex (MHC) class I genes termed MIC (MHC class I chain-related genes), was identified near the HLA-B gene, and a triplet repeat microsatellite polymorphism was found in the transmembrane (TM) region. Because a strong association with BD of one particular MICA-TM allele, A6, was shown in a Japanese population, the present study was conducted to investigate microsatellite polymorphism in Greek patients with BD to know whether this association is generally observed in BD occurring in other populations. METHODS: Thirty-eight Greek patients with BD and 40 ethnically matched control subjects were examined for MICA microsatellite polymorphism using polymerase chain reaction (PCR) and subsequent automated fragment detection by fluorescent-based technology. RESULTS: Similar to the Japanese patients with BD, the phenotype frequency of the MICA-TM A6 allele was significantly increased in the Greek patients with BD (50.0% in control subjects versus 86.8% in BD cases), with an odds ratio (OR) of 6.60 (P = 0.0012). The MICA-A6 allele was found in a high frequency both in males and females (weighted OR = 6.68; P = 0.0017). No association was found between the A6 allele and several disease features. A strong association exists between the MICA-TM A6 allele and the B*5101 allele in both the control subjects and patients with BD (weighted OR = 44.39; P = 0.0000023). CONCLUSIONS: This study revealed in Greek patients a strong association of BD with a particular MICA-TM allele, MICA-A6, providing insight into the molecular mechanism underlying the development of BD. (+info)
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Hulusi BehcetSymptoms of Behcet's syndromeDiseaseDiagnosisAutoinflammatory syndromeEtiologyBehcet's Syndrome SocietyManifestationsDiseasesVasculitisAutoimmuneInflammationUlcersOnsetInflammatoryClinicalParenchymalDisordersArthritisThrombosisPeople with Behcet's syndromeComplication of Behcet's syndromeTurkishInvolvementEncephalitisAbdominalDisorderNervous systemSymptomPatientsColitisTreatmentLesionsTreatmentsSearch
Hulusi Behcet3
- Turkish dermatologist, Hulusi Behcet (1889-1948) recognized and reported in 1937 symptoms of Behcet's syndrome. (targetwoman.com)
- The disease was first described in the 1930s by a Turkish dermatologist, Hulusi Behcet, who noted a set of three symptoms: canker sores, genital ulcers and recurrent eye inflammation. (colgate.com)
- In 1937, Hulusi Behcet, a Turkish dermatologist, described a disease associating uveitis (inflammation of the uvea, the middle coat of the eye comprising the choroid, ciliary body, and the iris) with genital and oral ulcers. (healthcentral.com)
Symptoms of Behcet's syndrome5
- In many cases, the symptoms of Behcet's syndrome last a few weeks and then go away, but they can return and also cause scarring. (reference.com)
- What are the symptoms of Behcet's syndrome? (hellodoktor.com)
- Because it is a chronic disease, symptoms of Behcet's syndrome may appear and disappear even while a patient undergoes treatment. (colgate.com)
- The repeated symptoms of Behcet's syndrome may be too disruptive. (unitedhealthdirectory.com)
- The symptoms of Behcet's syndrome all depend on the affected area of the body. (naturalcurefor.com)
Disease28
- Behcet's syndrome is a disease that involves vasculitis , which is inflammation of the blood vessels. (medlineplus.gov)
- I have been suspected for behcet disease last year , I am having headache everyday since ch. (medhelp.org)
- Anterior spinal cord syndrome in a patient with behcet's disease. (thefreelibrary.com)
- Here we report a BD patient with spinal cord disease that is notable because he was presented with anterior spinal cord syndrome (ASCS). (thefreelibrary.com)
- To determine the effectiveness of XOMA 052 as a treatment for inflammation in adults with the autoinflammatory diseases Familial Cold Autoinflammatory Syndrome (FCAS)/Muckle-Wells Syndrome (MWS) and Behcet's Disease. (clinicaltrials.gov)
- This exploratory study aims to examine the utility of the experimental drug candidate, XOMA 052 (XOMA (US), LLC) in the treatment of adult subjects with the autoinflammatory disorders familial cold autoinflammatory syndrome (FCAS) or Muckle-Wells Syndrome (MWS) associated with mutations in cryopyrin-encoding CIAS1 and in adult subjects with Behcet's Disease (BD), a disease which may be responsive to IL-1 blockade. (clinicaltrials.gov)
- Behcet disease is a poorly understood disorder of inflammation in several organ systems including the gastrointestinal tract, the skin, the eye, and the genitalia. (arizona.edu)
- Behcet disease (BD) is a systemic autoimmune vasculitis also of unknown cause. (kjim.org)
- In the absence of a cure or a single test to definitely determine Behcet's syndrome or Behcet's disease , educate about the syndrome to seek prompt medical attention for treatment. (targetwoman.com)
- Morbus Behcet or Silk Road disease is the other name for Behcet Syndrome or disease. (targetwoman.com)
- Though the clinical feature of auto immunity is absent, Behcet's syndrome is classified as an autoimmune disease as it has various aspects related to autoimmune disease. (targetwoman.com)
- Behcet's disease or Behcet's syndrome is a rare autoimmune disease that causes inflammation of blood vessels throughout the body. (colgate.com)
- Behcet's (beh-CHETS) disease, also called Behcet's syndrome, is a rare disorder that causes blood vessel inflammation throughout your body. (mayoclinic.org)
- Most references report that in early oral ulcers in Behcet's Disease (BD) (aka Behcet's syndrome, BS), there is an intense lymphomonocytic infiltration (mononuclear T-cells) around blood vessels, but as the ulcer ages, the infiltration of neutrophils (polymorphonuclear leucocytes (PMNL) or polymorphoneuclear neutrophils (PMN)) increases. (angelfire.com)
- However, the genetic roles of these miRNAs remain unclear in Behcet's disease (BD) and Vogt-Koyanagi-Harada (VKH) syndrome. (cdc.gov)
- Jugular Vein Thrombosis after Dental Extraction, from Lemierre's Syndrome to Behcet's Disease', TANAFFOS (Respiration) , 17(4), pp. 291-294. (tanaffosjournal.ir)
- OBJECTIVE: Behcet s disease is a multisystemic, vascular-inflammatory disease of unknown origin. (tjn.org.tr)
- In 14 patients, the diagnosis of Behcet s disease was present for 11.5 years, while four patients were newly diagnosed after admission. (tjn.org.tr)
- MRI is a noninvasive diagnostic tool to confirm the involvement of the central nervous system and has an important role in confirming the stage of the illness in Behcet s disease. (tjn.org.tr)
- MicroRNA-146a and Ets-1 gene polymorphisms in ocular Behcet's disease and Vogt-Koyanagi-Harada syndrome. (cdc.gov)
- The purpose of this study is to assess whether Apremilast is safe and effective in the treatment of patients with Behcet Disease. (bioportfolio.com)
- Treatment of the Median Arcuate Ligament Syndrome in a Patient With Behcet's Disease Median Arcuate Ligament Syndrome accompanying to Behcet's disease. (bioportfolio.com)
- Recurrent Iliofemoral Venous Thrombosis in the Setting of May-Thurner Syndrome as the Presenting Symptom of Behcet's Disease. (bioportfolio.com)
- Adalimumab for treatment of hemophagocytic syndrome following unrelated bone marrow transplantation in a boy with Behcet's disease and secondary myelodysplastic syndrome. (bioportfolio.com)
- Neuro-Behcet's autoimmune disease, also commonly referred to as Behcet's syndrome, is a very rare disorder that causes chronic inflammation in blood vessels. (medicalmarijuanainc.com)
- Currently, only the state of Illinois has approved medical marijuana for the treatment of Neuro-Behcet autoimmune disease. (medicalmarijuanainc.com)
- In addition, a number of other states will consider allowing medical marijuana to be used for the treatment of Neuro-Behcet autoimmune disease with the recommendation from a physician. (medicalmarijuanainc.com)
- Several states have approved medical marijuana specifically to treat "chronic pain," a symptom associated with Neuro-Behcet autoimmune disease. (medicalmarijuanainc.com)
Diagnosis3
- The diagnosis of Behcet's syndrome depends on the physical examinations, because no laboratory tests may detect the syndrome. (unitedhealthdirectory.com)
- Clinical manifestations and diagnosis of Behcet syndrome. (mayoclinic.org)
- METHODS: Thirty-eight patients admitted to the Haydarpasa Numune Training and Research Hospital, Department of 1st Neurology and GATA Haydarpasa Training Hospital Neurology Department, Istanbul between 2003 and 2009 in the acute period and with the diagnosis of neuro-Behcet s syndrome were investigated. (tjn.org.tr)
Autoinflammatory syndrome2
- 57 Familial Behcet-like autoinflammatory syndrome is an autosomal dominant disorder characterized by ulceration of mucosal surfaces, particularly in the oral and genital areas. (malacards.org)
- An important gene associated with Autoinflammatory Syndrome, Familial, Behcet-Like is TNFAIP3 (TNF Alpha Induced Protein 3). (malacards.org)
Etiology4
- Behçet's syndrome (BS) is a systemic inflammatory disorder with unknown etiology. (uzh.ch)
- Myelodysplastic syndrome (MDS) is a heterogeneous group of stem cell disorders of unknown etiology. (kjim.org)
- Behcet's syndrome (BS) is a systemic vasculitis of unknown etiology. (istanbul.edu.tr)
- Guillain-Barre syndrome (GBS), also known as an acute inflammatory demyelinating polyneuropathy, is an acute demyelinating polyradiculopathy of uncertain etiology. (bvsalud.org)
Behcet's Syndrome Society2
- Behcet's Syndrome Society United Kingdom patient support group with information on the condition. (inter.rs)
- If you have this condition, I strongly recommend that you join the Behcet's Syndrome Society . (netdoctor.co.uk)
Manifestations2
- Arthritis occurs in approximately 50% of cases and may precede, accompany or follow other manifestations of the syndrome. (irishhealth.com)
- Systemic corticosteroids continue to be useful therapy for most manifestations of Behcet's syndrome. (healthcentral.com)
Diseases5
- Dr. Yazici is also the Director of the Seligman Center for Advanced Therapeutics at the NYU Hospital for Joint Diseases and Director of the Behcet's Syndrome Evaluation, Treatment and Research Center at NYU Hospital for Joint Diseases. (vasculitisfoundation.org)
- Interestingly, not much increased atherosclerosis is seen in Behcet's syndrome when compared to other inflammatory diseases. (medeniyet.edu.tr)
- Diseases associated with GIMAP4 include Behcet Syndrome . (genecards.org)
- Other common diseases it treats include familial Mediterranean fever which leads to recurrent fevers, and Behcet's syndrome which is characterized by recurrent oral and genital ulcers. (aocd.org)
- Diseases associated with TXK include Behcet Syndrome and Leukoencephalopathy With Vanishing White Matter . (genecards.org)
Vasculitis5
- Behcet's syndrome (BS) is a rare, chronic, relapsing multisystem vasculitis affecting arteries and veins of all sizes. (clinicaladvisor.com)
- Behcet's syndrome (BD) is a controversial, chronic, and episodic condition that is autoimmune in origin and causes systemic vasculitis in the arteries and genital veins. (eurekaselect.com)
- Those resembling erythema nodosum (EN) show small vessel vasculitis and perivascular lymphocytic and mononuclear cell infiltration and fibrin deposition in the vessel wall, while the punched out ulcers are characterized by a leucocytoclastic vasculitis (neutrophil infiltrate) with fibrinoid necrosis. (angelfire.com)
- Behcet's syndrome (BS) is a systemic vasculitis, clinically characterized by different organ involvement and often complicated by thrombosis which occurs in vessels of all sizes. (istanbulc.edu.tr)
- A rare form of ocular (eye) involvement in this syndrome is retinal vasculitis which presents with painless decrease of vision with the possibility of floaters or visual field defects. (wikipedia.org)
Autoimmune1
- Autoimmune myasthenia gravis needs to be distinguished from congenital myasthenic syndromes. (medindia.net)
Inflammation10
- Inflammation of the vascular system from Behcet's syndrome can cause blood clots or even aneurysms, according to Mayo Clinic. (reference.com)
- Pathologic examination showed chronic ulcerative inflammation with lymphocyte infiltration compatible with Behcet colitis ( Fig. 2 ). (kjim.org)
- Sudden inflammation of the eyes is a common symptom of Behcet's syndrome. (targetwoman.com)
- Behcet's syndrome involves inflammation of many areas. (naturalcurefor.com)
- Other areas of body that can be affected by the inflammation of Behcet's syndrome include the retina, brain, joints, skin, and bowels. (naturalcurefor.com)
- Carpal tunnel syndrome (CTS), can also occur in BD patients secondary to inflammation in the connective tissues , vessels, and tendons , as well as nerve involvement in BD itself. (bvsalud.org)
- Behçet s syndrome is characterised by a triad of symptoms that includes oral and genital ulcers and eye inflammation. (irishhealth.com)
- Steroids are frequently used in the management of Behçet s syndrome and their purpose is to reduce inflammation wherever it may arise. (irishhealth.com)
- Inflammation of the eyes (anterior uveitis, posterior uveitis, or panuveitis) also affects individuals with Behçet's syndrome. (rarediseases.org)
- Some individuals with Behçet's syndrome may develop small eruptions that resemble acne (acneiform eruptions) and/or inflammation that mistakenly appear to affect the hair follicles on the skin (pseudofolliculitis). (rarediseases.org)
Ulcers9
- In the mouth or genitals, Behcet's syndrome can cause open sores known as ulcers. (reference.com)
- The most common symptom of Behcet's syndrome is the regular occurrence of ulcers in the mouth and genitals. (targetwoman.com)
- Lachmann (1982) reports that in biopsies of oral lesions from patients with recurrent oral ulcers (ROU) and Bechet's syndrome, a significant deposition of immunoglobulin (Ig) was not detected. (angelfire.com)
- In a single patient previously diagnosed with Behçet syndrome with recurrent oral aphthous ulcers, quadruple therapy (proton pump inhibitor, bismuth, tetracycline, and metronidazole), for histologically positive H pylori determined by upper gastrointestinal endoscopy, reduced the development of new ulcers and the frequency of recurrent attacks for less than 1 month. (medscape.com)
- Behçet's syndrome is a rare multisystem inflammatory disorder characterized by ulcers affecting the mouth and genitals, various skin lesions, and abnormalities affecting the eyes. (rarediseases.org)
- Individuals with Behçet's syndrome may also have recurring ulcers in the digestive tract. (rarediseases.org)
- Behcet's syndrome is a condition in which ulcers develop on the genitals and in the mouth. (netdoctor.co.uk)
- Behçet's syndrome is a condition in which ulcers develop on the genitals (male or female) and in the mouth. (netdoctor.co.uk)
- This is a double-blind placebo controlled study targeting individuals with active Behcet's Syndrome who have oral ulcers and are resistant (have not responded after 4 weeks) to conventiona. (bioportfolio.com)
Onset2
- This may occur before, during, or after the onset of the other symptoms associated with Behçet's syndrome. (rarediseases.org)
- Tocilizumab will be administered prior to transplantation in order to prevent the onset of cytokine release syndrome and its complications associated to peripheral blood haploidentical hem. (bioportfolio.com)
Inflammatory2
- Behcet Syndrome is a medical condition in which a relapsing chronic inflammatory disorder that may produce painful, recurring skin blisters, mouth sores, swollen joints, or genital sores, occurs. (unitedhealthdirectory.com)
- Behcet's syndrome is a rare inflammatory multisystem disorder that is genetically linked and is still under research to identify a suitable cure. (medindia.net)
Clinical1
- His areas of interest are rheumatoid arthritis, early arthritis, patient reported outcomes, database and registry management and monitoring of arthritis patients in regard to clinical response and adverse events related to treatment and Behcet's syndrome. (vasculitisfoundation.org)
Parenchymal2
- 4) Although subacute meningoencephalitis accounts for 75% of cases with parenchymal involvement, different syndromes might be encountered during the course of parenchymal NBD. (thefreelibrary.com)
- In this study, we aimed to determine the cranial magnetic resonance imaging (MRI) patterns in patients diagnosed as parenchymal or nonparenchymal neuro-Behcet s syndrome who did not have headache. (tjn.org.tr)
Disorders3
- ICD-9 code 711.27 for Arthropathy in behcet's syndrome involving ankle and foot is a medical classification as listed by WHO under the range -ARTHROPATHIES AND RELATED DISORDERS (710-719). (aapc.com)
- Natalia P. de Oliveira Ribeiro, Alexandre R. de Mello Schier, Tamires M. Pessoa, Valeska M. Pereira, Sergio Machado, Oscar Arias-Carrion, Antonio E. Nardi and Adriana Cardoso, "Depression as a Comorbidity in Behcet's Syndrome", CNS & Neurological Disorders - Drug Targets (2014) 13: 1041. (eurekaselect.com)
- Costello syndrome shows early phenotypic overlap with other disorders that involve MAP KINASE SIGNALING SYSTEM (e.g. (bioportfolio.com)
Arthritis4
- Celgen Corp's apremilast, which is pending approval in the USA for psioratic arthritis, is showing promise in the treatment of Behcet's syndrome. (pharmatimes.com)
- About 50% of patients with Behcet's syndrome may have a relatively mild, nonprogressive knee arthritis and other large joints. (unitedhealthdirectory.com)
- a trial of prophylactic penicillin treatment was found to decrease the number of acute arthritis episodes in patients with Beh?et's syndrome. (naturalcurefor.com)
- 22. SLE, rheumatoid arthritis, Sjögren's syndrome. (wiley.com)
Thrombosis3
- Of the two patients with nonparenchymal neuro-Behcet s syndrome, thrombosis was observed in the superior sagittal sinus in one and in the transverse sinus in the other. (tjn.org.tr)
- Objectives: Lower extremity deep vein thrombosis (LEDVT) is a serious complication of Behcet's syndrome. (istanbulc.edu.tr)
- citation needed] Neurological involvements range from aseptic meningitis to vascular thrombosis such as dural sinus thrombosis and organic brain syndrome manifesting with confusion, seizures, and memory loss. (wikipedia.org)
People with Behcet's syndrome2
- Almost all people with Behcet's syndrome have repeated painful sores in the mouth, which are common first symptoms. (unitedhealthdirectory.com)
- In recent years, it's become clear that a lot of people with Behcet's syndrome are troubled by disabling headaches. (netdoctor.co.uk)
Complication of Behcet's syndrome1
- Sores on the eyes are a potential major complication of Behcet's syndrome and can lead to blindness if they appear on the retina. (reference.com)
Turkish1
- Journal of Dr. Behcet Uz Children's Hospital" is indexed by the Web of Science-Emerging Sources Citation Index, EBSCO, Google Scholar, Microsoft Academic Search, T B TAK/ULAKB M, T rk Medline and the Turkish Citation Index. (behcetuzdergisi.com)
Involvement2
- We aim to ascertain the possible involvement of functional IL10 and TNF-alpha promoter polymorphisms on the susceptibility to Behcet's syndrome (BS), to examine whether IL10 and TNF-alpha genotypes might work synergistically influencing susceptibility to BS. (istanbul.edu.tr)
- Approximately 10%-20% of individuals with Behçet's syndrome also have involvement of the central nervous system. (rarediseases.org)
Encephalitis1
- 88. The syndrome of acute encephalitis. (wiley.com)
Abdominal3
- In the digestive system, Behcet's syndrome can cause bleeding, abdominal pain and diarrhea. (reference.com)
- In spite of active management of Behcet colitis, the abdominal pain persisted in a waxing and waning manner. (kjim.org)
- Many patients with BD often complain about abdominal tenderness, bloating, and generic abdominal discomfort that closely mimics irritable bowel syndrome. (wikipedia.org)
Disorder2
- Rett Syndrome is a neurodevelopmental disorder occuring exclusively in females. (unitedhealthdirectory.com)
- Sweet''s syndrome or acute febrile neutrophilic dermatosis is a skin disorder with no specific cause. (medindia.net)
Nervous system2
- Impairment of the central nervous system is rare, and young adults can present with brain stem syndrome or hemiparesis. (tjn.org.tr)
- 25. Behcet's syndrome and the nervous system. (wiley.com)
Symptom2
- The earliest symptom of Behçet's syndrome is usually painful canker sores on the mucous membranes that line the mouth (aphthous stomatitis). (rarediseases.org)
- In some cases, eye abnormalities may be the first symptom of Behçet's syndrome. (rarediseases.org)
Patients7
- He divides his time between seeing patients and running the Seligman center, conducting both industry and investigator initiated trials, in the areas of RA and Behcet's syndrome. (vasculitisfoundation.org)
- This rare syndrome is caused by hypoperfusion of the anterior spinal artery, leading to ischemia in the anterior two thirds of the spinal cord, and to our knowledge has not been previously reported in patients with BD. (thefreelibrary.com)
- The treatment of MDS-related Behcet colitis is usually diff icult to manage, and many patients eventually die of infection or hemorrhage. (kjim.org)
- Iritis, posterior uveitis, retinal vessel occlusions, and optic neuritis can be seen in some patients with the syndrome. (medicowesome.com)
- Johns Hopkins Medicine reports that the HLA-B51 gene is found in some patients with Behcet's syndrome, though the presence of the gene alone does not cause Behcet's. (colgate.com)
- Skin hypersensitivity is seen in most Behcet patients with pus and redness of the skin developing within 24 hours at the site of a pinprick into sterile skin. (healthcentral.com)
- Conclusion: Sweet syndrome should be kept in mind when erythematous rashes develop in patients with febrile neutropenia who have been using G-CSF for a long time and who have not been able to control their fever despite appropriate antibiotics and antifungals. (behcetuzdergisi.com)
Colitis1
- We herein report a case of intractable MDS-related Behcet colitis that was successfully treated by allogeneic hematopoietic stem cell transplantation (HSCT). (kjim.org)
Treatment1
- There is no cure for Behcet Syndrome, but certain symptoms may generally be relieved by treatment. (unitedhealthdirectory.com)
Lesions2
- Erythema Nodosum(EN)-like lesions involve painful, erythematous nodule on peritibial tissue as well as face, neck, forearms and buttocks areas that resolve without ulceration in 2-3 weeks. (clinicaladvisor.com)
- Background Papulopustular lesions (PPL) are the most common skin lesions in Behçet's syndrome (BS). (bmj.com)
Treatments1
- There are a number of treatments available for Behcet's syndrome. (healthsearchonline.com)
Search1
- These images are a random sampling from a Bing search on the term "Behcets Syndrome. (fpnotebook.com)