Bee Venoms: Venoms obtained from Apis mellifera (honey bee) and related species. They contain various enzymes, polypeptide toxins, and other substances, some of which are allergenic or immunogenic or both. These venoms were formerly used in rheumatism to stimulate the pituitary-adrenal system.Bees: Insect members of the superfamily Apoidea, found almost everywhere, particularly on flowers. About 3500 species occur in North America. They differ from most WASPS in that their young are fed honey and pollen rather than animal food.Melitten: Basic polypeptide from the venom of the honey bee (Apis mellifera). It contains 26 amino acids, has cytolytic properties, causes contracture of muscle, releases histamine, and disrupts surface tension, probably due to lysis of cell and mitochondrial membranes.Crotalid Venoms: Venoms from snakes of the subfamily Crotalinae or pit vipers, found mostly in the Americas. They include the rattlesnake, cottonmouth, fer-de-lance, bushmaster, and American copperhead. Their venoms contain nontoxic proteins, cardio-, hemo-, cyto-, and neurotoxins, and many enzymes, especially phospholipases A. Many of the toxins have been characterized.Venoms: Poisonous animal secretions forming fluid mixtures of many different enzymes, toxins, and other substances. These substances are produced in specialized glands and secreted through specialized delivery systems (nematocysts, spines, fangs, etc.) for disabling prey or predator.Wasp Venoms: Venoms produced by the wasp (Vespid) family of stinging insects, including hornets; the venoms contain enzymes, biogenic amines, histamine releasing factors, kinins, toxic polypeptides, etc., and are similar to bee venoms.Cobra Venoms: Venoms from snakes of the genus Naja (family Elapidae). They contain many specific proteins that have cytotoxic, hemolytic, neurotoxic, and other properties. Like other elapid venoms, they are rich in enzymes. They include cobramines and cobralysins.Phospholipases A2: Phospholipases that hydrolyze the acyl group attached to the 2-position of PHOSPHOGLYCERIDES.Viper Venoms: Venoms from SNAKES of the viperid family. They tend to be less toxic than elapid or hydrophid venoms and act mainly on the vascular system, interfering with coagulation and capillary membrane integrity and are highly cytotoxic. They contain large amounts of several enzymes, other factors, and some toxins.Phospholipases A: Phospholipases that hydrolyze one of the acyl groups of phosphoglycerides or glycerophosphatidates.Elapid Venoms: Venoms from snakes of the family Elapidae, including cobras, kraits, mambas, coral, tiger, and Australian snakes. The venoms contain polypeptide toxins of various kinds, cytolytic, hemolytic, and neurotoxic factors, but fewer enzymes than viper or crotalid venoms. Many of the toxins have been characterized.Spider Venoms: Venoms of arthropods of the order Araneida of the ARACHNIDA. The venoms usually contain several protein fractions, including ENZYMES, hemolytic, neurolytic, and other TOXINS, BIOLOGICAL.Group III Phospholipases A2: A subcategory of secreted phospholipases A2 with specificity for PHOSPHATIDYLETHANOLAMINES and PHOSPHATIDYLCHOLINE. It occurs as a component of VENOMS and as a mammalian secretory phospholipase A2. The creation of this group is based upon similarities in the structural determinants of the enzymes including a long amino-terminal domain, a conserved group III-specific domain, and a long carboxyl-terminal domain.Apamin: A highly neurotoxic polypeptide from the venom of the honey bee (Apis mellifera). It consists of 18 amino acids with two disulfide bridges and causes hyperexcitability resulting in convulsions and respiratory paralysis.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Scorpion Venoms: Venoms from animals of the order Scorpionida of the class Arachnida. They contain neuro- and hemotoxins, enzymes, and various other factors that may release acetylcholine and catecholamines from nerve endings. Of the several protein toxins that have been characterized, most are immunogenic.Insect Bites and Stings: Bites and stings inflicted by insects.Desensitization, Immunologic: Immunosuppression by the administration of increasing doses of antigen. Though the exact mechanism is not clear, the therapy results in an increase in serum levels of allergen-specific IMMUNOGLOBULIN G, suppression of specific IgE, and an increase in suppressor T-cell activity.Acupuncture Points: Designated locations along nerves or organ meridians for inserting acupuncture needles.Hymenoptera: An extensive order of highly specialized insects including bees, wasps, and ants.Bothrops: A genus of poisonous snakes of the VIPERIDAE family. About 50 species are known and all are found in tropical America and southern South America. Bothrops atrox is the fer-de-lance and B. jararaca is the jararaca. (Goin, Goin, and Zug, Introduction to Herpetology, 3d ed, p336)Antivenins: Antisera used to counteract poisoning by animal VENOMS, especially SNAKE VENOMS.Fish Venoms: Venoms produced by FISHES, including SHARKS and sting rays, usually delivered by spines. They contain various substances, including very labile toxins that affect the HEART specifically and all MUSCLES generally.Antibiosis: A natural association between organisms that is detrimental to at least one of them. This often refers to the production of chemicals by one microorganism that is harmful to another.Snake Venoms: Solutions or mixtures of toxic and nontoxic substances elaborated by snake (Ophidia) salivary glands for the purpose of killing prey or disabling predators and delivered by grooved or hollow fangs. They usually contain enzymes, toxins, and other factors.Phospholipases: A class of enzymes that catalyze the hydrolysis of phosphoglycerides or glycerophosphatidates. EC 3.1.-.Elapidae: A family of extremely venomous snakes, comprising coral snakes, cobras, mambas, kraits, and sea snakes. They are widely distributed, being found in the southern United States, South America, Africa, southern Asia, Australia, and the Pacific Islands. The elapids include three subfamilies: Elapinae, Hydrophiinae, and Lauticaudinae. Like the viperids, they have venom fangs in the front part of the upper jaw. The mambas of Africa are the most dangerous of all snakes by virtue of their size, speed, and highly toxic venom. (Goin, Goin, and Zug, Introduction to Herpetology, 3d ed, p329-33)Anthropometry: The technique that deals with the measurement of the size, weight, and proportions of the human or other primate body.Equol: A non-steroidal ESTROGEN generated when soybean products are metabolized by certain bacteria in the intestines.Mollusk Venoms: Venoms from mollusks, including CONUS and OCTOPUS species. The venoms contain proteins, enzymes, choline derivatives, slow-reacting substances, and several characterized polypeptide toxins that affect the nervous system. Mollusk venoms include cephalotoxin, venerupin, maculotoxin, surugatoxin, conotoxins, and murexine.

IL-10-induced anergy in peripheral T cell and reactivation by microenvironmental cytokines: two key steps in specific immunotherapy. (1/345)

Specific immunotherapy (SIT) is widely used for treatment of allergic diseases and could potentially be applied in other immunological disorders. Induction of specific unresponsiveness (anergy) in peripheral T cells and recovery by cytokines from the tissue microenvironment represent two key steps in SIT with whole allergen or antigenic T cell peptides (PIT). The anergy is directed against the T cell epitopes of the respective antigen and characterized by suppressed proliferative and cytokine responses. It is initiated by autocrine action of IL-10, which is increasingly produced by the antigen-specific T cells. Later in therapy, B cells and monocytes also produce IL-10. The anergic T cells can be reactivated by different cytokines. Whereas IL-15 and IL-2 generate Th1 cytokine profile and an IgG4 antibody response, IL-4 reactivates a Th2 cytokine pattern and IgE antibodies. Increased IL-10 suppresses IgE and enhances IgG4 synthesis, resulting in a decreased antigen-specific IgE:IgG4 ratio, as observed normally in patients after SIT or PIT. The same state of anergy against the major bee venom allergen, phospholipase A2, can be observed in subjects naturally anergized after multiple bee stings. Together, these data demonstrate the pivotal role of autocrine IL-10 in induction of specific T cell anergy and the important participation of the cytokine microenvironment in SIT. Furthermore, knowledge of the mechanisms explaining reasons for success or failure of SIT may enable possible predictive measures of the treatment.  (+info)

Lipolytic modification of LDL by phospholipase A2 induces particle aggregation in the absence and fusion in the presence of heparin. (2/345)

One of the first events in atherogenesis is modification of low density lipoprotein (LDL) particles in the arterial wall with ensuing formation of aggregated and fused lipid droplets. The accumulating particles are relatively depleted in phosphatidylcholine (PC). Recently, secretory phospholipase A2 (PLA2), an enzyme capable of hydrolyzing LDL PC into fatty acid and lysoPC molecules, has been found in atherosclerotic arteries. There is also evidence that both LDL and PLA2 bind to the glycosaminoglycan (GAG) chains of extracellular proteoglycans in the arterial wall. Here we studied the effect of heparin GAG on the lipolytic modification of LDL by PLA2. Untreated LDL, heparin-treated LDL, and heparin-bound LDL were lipolyzed with bee venom PLA2. In the presence of albumin, lipolysis resulted in aggregation in all 3 preparations of the LDL particles. Lipolysis of untreated LDL did not result in aggregation if albumin was absent from the reaction medium, and the lipolytic products accumulated in the particles rendering them negatively charged. However, heparin-treated and heparin-bound lipolyzed LDL particles aggregated even in the absence of albumin. Importantly, in the presence of albumin, some of the heparin-treated and heparin-bound lipolyzed LDL particles fused, the proportion of fused particles being substantially greater when LDL was bound to heparin during lipolysis. In summary, lipolysis of LDL PC by PLA2 under physiological conditions, which allow transfer of the lipolytic degradation products to albumin, leads to fusion of LDL particles in the presence, but not in the absence, of heparin. Thus, it is possible that within the GAG meshwork of the arterial intima, PLA2-induced modification of LDL is one source of the lipid droplets during atherogenesis.  (+info)

Update on the status of Africanized honey bees in the western states. (3/345)

The Africanized honey bee (AHB), Apis mellifera scutella--perhaps better known as the "killer bee"--has arrived in the western United States and in southern California, following a nearly 50-year north-ward migration across South and Central America. First detected near Hidalgo, Texas in October 1993, the bees continue to advance 100 to 300 miles per year by colonizing existing hives or forming new hives in the wild. Although the AHB's "killer" reputation has been greatly exaggerated, the presence of AHBs will increase the chances of people being stung.  (+info)

Mass envenomations by honey bees and wasps. (4/345)

Stinging events involving honey bees and wasps are rare; most deaths or clinically important incidents involve very few stings (< 10) and anaphylactic shock. However, mass stinging events can prove life-threatening via the toxic action of the venom when injected in large amounts. With the advent of the Africanized honey bee in the southwestern United States and its potential for further spread, mass envenomation incidents will increase. Here we review the literature on mass stinging events involving honey bees and wasps (i.e., yellowjackets, wasps, and hornets). Despite different venom composition in the two insect groups, both may cause systemic damage and involve hemolysis, rhabdomyolysis, and acute renal failure. Victim death may occur due to renal failure or cardiac complications. With supportive care, however, most victims should be able to survive attacks from hundreds of wasps or approximately 1000 honey bees.  (+info)

Ultraviolet Raman examination of the environmental dependence of bombolitin I and bombolitin III secondary structure. (5/345)

Bombolitin I and III (BI and BIII) are small amphiphilic peptides isolated from bumblebee venom. Although they exist in predominately nonhelical conformations in dilute aqueous solutions, we demonstrate, using UV Raman spectroscopy, that they become predominately alpha-helical in solution at pH > 10, in high ionic strength solutions, and in the presence of trifluoroethanol (TFE) and dodecylphosphocholine (DPC) micelles. In this paper, we examine the effects of electrostatic and hydrophobic interactions that control folding of BI and BIII by systematically monitoring their secondary structures as a function of solution conditions. We determine the BI and BIII secondary structure contents by using the quantitative UV Raman methodology of Chi et al. (1998. Biochemistry. 37:2854-2864). Our findings suggest that the alpha-helix turn in BIII at neutral pH is stabilized by a salt bridge between residues Asp2 and Lys5. This initial alpha-helical turn results in different BI and BIII alpha-helical folding mechanisms observed in high pH and high salt concentrations: BIII folds from its single alpha-helix turn close to its N-terminal, whereas the BI alpha-helix probably nucleates within the C-terminal half. We also used quasielastic light scattering to demonstrate that the BI and BIII alpha-helix formation in 0.2 M Ca(ClO4)2 is accompanied by formation of trimers and hexamers, respectively.  (+info)

On the diversity and heterogeneity of H-2(d)-restricted determinants and T cell epitopes from the major bee venom allergen. (6/345)

One of the main limitations of using synthetic peptides for immunotherapy in allergic patients is the difficulty to delineate the immunodominant T cell epitopes which are necessarily dependent on HLA molecules. We have thus addressed the question of the role of MHC II molecules in immunodominant epitopes selection in the particular case of the major bee venom allergen (API m1). To exhaustively and easily explore it, we used BALB/c mice whose H-2 haplotype is associated with high IgE and IgG responses to API m1. By means of extensive sets of synthetic peptides, we investigated the specificity of polyclonal T cells and monoclonal hybridomas from mice immunized with API m1 and delineated four immunodominant regions, restricted to either the I-E(d) or the I-A(d) molecule. All the peptides were also tested for their capacity to bind to immunopurified MHC II molecules. Eight determinants of high affinity were identified. They clustered into three distinct regions and were largely overlapping. They included all the immunodominant epitopes, but half of them were not capable of stimulating T cells. Strikingly, interacting surfaces with either the TCR or MHC II molecule greatly differed from one determinant to another. In one case, we observed that flanking regions exerted a particular action on T cell stimulation which prevented the fine epitope localization. Our results underline the diversity and complexity of MHC II-restricted determinants and T cell epitopes from the major bee venom allergen, even in a single haplotype. These data also participate in the development of alternative approaches to conventional immunotherapy.  (+info)

Secreted phospholipases A(2), a new class of HIV inhibitors that block virus entry into host cells. (7/345)

Mammalian and venom secreted phospholipases A(2) (sPLA(2)s) have been associated with a variety of biological effects. Here we show that several sPLA(2)s protect human primary blood leukocytes from the replication of various macrophage and T cell-tropic HIV-1 strains. Inhibition by sPLA(2)s results neither from a virucidal effect nor from a cytotoxic effect on host cells, but it involves a more specific mechanism. sPLA(2)s have no effect on virus binding to cells nor on syncytia formation, but they prevent the intracellular release of the viral capsid protein, suggesting that sPLA(2)s block viral entry into cells before virion uncoating and independently of the coreceptor usage. Various inhibitors and catalytic products of sPLA(2) have no effect on HIV-1 infection, suggesting that sPLA(2) catalytic activity is not involved in the antiviral effect. Instead, the antiviral activity appears to involve a specific interaction of sPLA(2)s to host cells. Indeed, of 11 sPLA(2)s from venom and mammalian tissues assayed, 4 venom sPLA(2)s were found to be very potent HIV-1 inhibitors (ID(50) < 1 nM) and also to bind specifically to host cells with high affinities (K(0.5) < 1 nM). Although mammalian pancreatic group IB and inflammatory-type group IIA sPLA(2)s were inactive against HIV-1 replication, our results could be of physiological interest, as novel sPLA(2)s are being characterized in humans.  (+info)

A novel Fab-based antivenom for the treatment of mass bee attacks. (8/345)

The frequency of mass bee attacks has dramatically increased in the Americas following the introduction and spread of the aggressive Africanized 'killer' bee (Apis mellifera scutellata). As yet no specific therapy is available, which led us to develop an ovine Fab-based antivenom as a potential new treatment. Sera from sheep immunized against the venom contained high levels of specific antibodies, as demonstrated by ELISA and by small-scale affinity chromatography, against both whole (A. m. mellifera) venom and purified melittin. A nerve muscle preparation was used to show the myotoxic effects of the venom and neutralization by the antivenom. Antivenom neutralizing ability was also demonstrated using assays for venom phospholipase A2 and in vivo activities. Venom from both European and Africanized bees appeared identical when analyzed by acid-urea gel electrophoresis. This antivenom may therefore provide the first specific therapy for the treatment of mass envenomation by either European or Africanized 'killer' bees.  (+info)

*Bodog F. Beck

There are no studies proving the ability of bee venom to cure any ailment. Bee venom therapy: Bee venom, its nature, and its ... "bee venom therapy" which he described in his book Bee venom therapy: Bee venom, its nature, and its effect on arthritic and ... His books have been reprinted since his death under new titles, Bee venom therapy as The bible of bee venom therapy, and Honey ... "bee venom therapy". There are no studies proving the ability of bee venom to cure any ailment. Bodog Beck was born in Budapest ...

*Tertiapin

As a paradox to the symptoms after a bee sting, bee venom is used for treatment of pain, inflammation (e.g. rheumatoid ... Tertiapin is a compound of the honey bee venom (apitoxin) that causes pain and signs of inflammation around the sting, but a ... Tertiapin is a 21-amino acid peptide isolated from venom of the European honey bee (Apis mellifera). It blocks two different ... Drici, MD; Diochot, S; Terrenoire, C; Romey, G; Lazdunski, M (2000). "The bee venom peptide tertiapin underlines the role of ...

*Apamin

... is an element in bee venom. You can come into contact with apamin through bee venom, so the symptoms that are known are ... Apamin is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom). Dry bee venom consists of 2-3% of apamin. Apamin ... Apamin was named after this bee. Bee venom contains many other compounds, like histamine, phospholipase A2, hyaluronidase, MCD ... The first symptoms of apitoxin (bee venom), that are now thought to be caused by apamin, were described back in 1936 by Hahn ...

*Genista tinctoria

N. Yoirish (2001). Curative Properties of Honey and Bee Venom. p. 111. ... The plant has been used in popular medicine and herbalism for various complaints, including skin diseases, even in modern times ... Numerous cultivars have been selected for garden use, of which 'Royal Gold' has gained the Royal Horticultural Society's Award ... The plant, as its Latin and common names suggest, has been used from ancient times for producing a yellow dye, which combined ...

*Vasily Krylov

He is the author of books (in Russian) including "Bee venom: Properties, reception, application" (1995), "Bee venom in ... He is known as a bee venom expert. He graduated from the N. I. Lobachevsky State University of Nizhny Novgorod in 1970. He was ... ISBN 978-5-903535-03-3 In English Krylov V.N., Sokolsky S.S. Experimental study of bee royal jelly cardioprotectiv ...

*Melittin

... is the principal active component of apitoxin (bee venom). Melittin is a peptide consisting of 26 amino acids. In ... Ma R, Mahadevappa R, Kwok HF (2017). "Venom-based peptide therapy: insights into anti-cancer mechanism". Oncotarget. 8: 100908- ...

*Glycoside hydrolase family 56

The amino acid sequence of bee venom hyaluronidase contains 349 amino acids, and includes four cysteines and a number of ... Gmachl M, Kreil G (1993). "Bee venom hyaluronidase is homologous to a membrane protein of mammalian sperm". Proc. Natl. Acad. ... The venom of Apis mellifera (Honeybee) contains several biologically-active peptides and two enzymes, one of which is a ...

*Xylocopa sonorina

It is unknown if people allergic to honeybee venom are also allergic to carpenter bee venom. Smith first described the species ... Carpenter bee venom is composed of proteins which can produce allergies; Some individuals must be stung in at least two ... Xylocopa sonorina, commonly known as the Sonoran carpenter bee, is a carpenter bee found in the eastern Pacific islands. Males ... Although valued for their pollination, carpenter bee nesting behavior often results in their classification as pests; The bees ...

*MCD peptide

... is also present in the venom of the honey bee Apis mellifera. MCD peptide is a cationic 22-amino acid residue ... Gmachl, M; Kreil, G (1995). "The precursors of the bee Venom Constituents Apamin and MCD Peptide Are Encoded by two Genes in ... In addition to MCD peptide, melittin and apamin have also been identified in this venom and are also described as voltage- ... "The characterization of high affinity binding sites in rat brain for the mast cell degranulating peptide from bee venom using ...

*Acupuncture

Bee venom acupuncture is a treatment approach of injecting purified, diluted bee venom into acupoints. A 2006 review of ... Lim SM, Lee SH (2015). "Effectiveness of bee venom acupuncture in alleviating post-stroke shoulder pain: a systematic review ... This has been cited as evidence that practices similar to acupuncture may have been practiced elsewhere in Eurasia during the ... Although acupuncture has been practiced for thousands of years in China, its use in pediatrics in the United States did not ...

*Apis andreniformis

For A. andreniformis specifically, some commercial products include royal jelly, wax, honey, and bee venoms. Additionally, they ... As stated previously, the presence of royal jelly on young female larva produced the queen bee. Drones, or male bees, are not ... Apis andreniformis, or the black dwarf honey bee, is a relatively rare species of honey bee whose native habitat is the ... The genus Apis includes honey bees, the most common being Apis mellifera, otherwise known as the Western honey bee. A. ...

*Nikolay Artemov

Bee Venom (in Russian) // Big Medical Encyclopedia Instruction for Bee Sting Venom Apitherapy (in Russian). Approved by the ... the USSR Ministry of Health sanctioned use bee venom in the treatment of certain ailments. It was the Instruction for Bee Sting ... New data on the scientific argumentation of the physiology of application of bee venom as a medicine // Apiacta 3, 1968 Krylov ... In 1941, his monograph "Bee venom, its physiological properties and therapeutic use" was published by the USSR Academy of ...

*Skin allergy test

The test is done to assess allergies to drugs like penicillin or bee venom. To ensure that the skin is reacting in the way it ... but the vast majority of these tests have no validity and have never been proven to work scientifically. RAST test Basophil ...

*Basophil activation

It can be used for different allergies (e.g. bee venom, drugs, contrast media). Degranulated cell expose CD63 molecules on ... Immunoglobulin E (IgE) is a class of antibody (or immunoglobulin "isotype") that has only been found in mammals. It plays an ...

*Margie Profet

... specifically bee venom. Bee venom induces allergic reactions in some people that can include anaphylactic shock and death. Both ... reported that Phospholipase A2-the major allergen in bee venom -- "is sensed by the innate immune system" and induces an immune ... Likewise, injecting mice with a small dose of bee venom conferred immunity to a much larger, fatal dose, Stanford researchers ... "Bee Venom Phospholipase A2 Induces a Primary Type 2 Response that Is Dependent on the Receptor ST2 and Confers Protective ...

*List of unproven and disproven cancer treatments

Apitherapy - the use of products derived from bees, such as honey and bee venom, as a therapy. Apitherapy has been promoted for ... "there have been no clinical studies in humans showing that bee venom or other honeybee products are effective in preventing or ... has been promoted as a cancer cure. However, it has been found to be ineffective and toxic; its promotion has been described as ... Chemicals derived from cannabis have been extensively studied for potential anti-cancer effect and while there has been much ...

*Rheumatism

The ancient Greeks recorded that bee venom had some beneficial effects on some types of rheumatism. Bee and ant stings were ... Cod liver oil has also been used as a remedy. Neem Tree Oil according to East Indian cultures has also been used as a remedy. ... Many rheumatic disorders of chronic, intermittent joint pain have historically been caused by infectious diseases. Their ... There has long been said to be a link between "rheumatic" pain and the weather. There appears to be no firm evidence in favour ...

*Nanosponges

... bee venom, snake venom and sea anemone venom. These venoms all use a pore-forming strategy, which is useful when dealing with ... Nanosponges are introduced to the body by injection, and take the form of a red blood cell so that the bacteria or venom ... Nanoparticles have been used for unknown preventative measures, such as silverware and wound care products. Silverware contains ... Researchers are posed with is how to tackle all the different types of bacteria and venom, making a lot of different ...

*Boris Orlov

Chemistry and Pharmacology of Bee Venom (A Review of the Literature) // Farmakol Toksikol 41 (3), 358-369. May-Jun 1978. " ...

*Apitoxin

... , or honey bee venom, is a bitter colorless liquid containing proteins, which may produce local inflammation. It may ... Apitherapy Bee sting Beekeeping Hive management Honeybee Wasp venoms Czarnetzki, B. M.; Thiele, T.; Rosenbach, T. (February ... Chaisakul, J; Hodgson, W. C; Kuruppu, S; Prasongsook, N (2016). "Effects of Animal Venoms and Toxins on Hallmarks of Cancer". ... The main component is melittin amounting to 52% of venom peptides. Apamin increases cortisol production in the adrenal gland ...

*Phospholipase A2

The extracellular forms of phospholipases A2 have been isolated from different venoms (snake, bee, and wasp), from virtually ... Nicolas JP, Lin Y, Lambeau G, Ghomashchi F, Lazdunski M, Gelb MH (Mar 1997). "Localization of structural elements of bee venom ... PLA2 enzymes are commonly found in mammalian tissues as well as arachnid, insect and snake venom. Venom from both snakes and ... It has been shown that in PLA2G12B null mice VLDL levels were greatly reduced, suggesting it could have an effect in ...

*Lipase

Certain wasp and bee venoms contain phospholipases that enhance the effects of injury and inflammation delivered by a sting. As ...

*Schmidt sting pain index

Since many small bees are categorized into a pain level of 1, it should be noted that the most toxic polypeptides in bee venom ... Melittin is the main toxin of bee venom, and it damages red blood cells and white blood cells. Apamin is a neurotoxin that ... Habermann, E. (28 July 1972). "Bee and Wasp Venoms". Science. 177 (4046): 314-322. doi:10.1126/science.177.4046.314. Schmidt, ... He has categorized a variety of wasps, bees, and ants into Pain Level 2, including the yellowjacket, the Asiatic honey bee, the ...

*Jack jumper ant

Substantial amounts of ant venom have been analysed to characterise venom components, and the jack jumper has been a main ... Venom is available; however, no commercial venom extract is available that can be used for skin testing. Venom extract is only ... The ant venom is particularly immunogenic for an insect venom; the venom causes about 90% of Australian ant allergies. In ... there had been no history of records of allergic reactions or study on their sting venom. The identification of venom allergens ...

*Osteopontin

Konno S, Hizawa N, Nishimura M, Huang SK (2007). "Osteopontin: a potential biomarker for successful bee venom immunotherapy and ... OPN has also been reported to be increased in the sputum supernatant of smoking asthmatics, as well as the BALF and bronchial ... It has been shown that OPN drives IL-17 production; OPN is overexpressed in a variety of cancers, including lung cancer, breast ... Osteopontin has been implicated as an important factor in bone remodeling. Specifically, research suggests it plays a role in ...

*Keating Five

To date none of that money has ever been recovered. John Granger was infamously known as the "White Ghost" around the banking ... ISBN 0-8129-2134-8. Tolchin, Martin; Tolchin, Susan J. (2003). Glass Houses: Congressional Ethics and the Politics of Venom. ... The accompanying slowdown in the finance industry and the real estate market may have been a contributing cause of the 1990- ... McCain denied doing so under oath, although several press reports concluded that McCain had been one of the main leakers during ...
TY - JOUR. T1 - Effective mast cell degranulating peptide inhibitors of the IgE/FcεRI receptor interaction. AU - Buku, Angeliki. AU - Keselman, Inna. AU - Lupyan, Dmitry. AU - Mezei, Mihaly. AU - Price, Joseph. PY - 2008/8/1. Y1 - 2008/8/1. N2 - Previous studies with mast cell degranulating (MCD) peptide have shown that peptide [Ala12]MCD 8 was an inhibitor of IgE binding to mast cell receptors. In an attempt to produce increased inhibition, analogs were synthesized that maintained the alanine residue in position 12 in the MCD peptide sequence and were further modified at both termini. Analogs modified at the C-terminus were [Ala12,desLys21]MCD 2 and [Ala 12,d-Lys21]MCD 4. N-terminus modifications were [desLys6-Arg7-His8,Ala12]MCD 1, [Ala6, Ala12]MCD 6, and [Val6,Ala 12]MCD 7. To assess the role of the Proline12, analogs [d-Ala12]MCD 3 and [Meleu12]MCD 5 were also synthesized. The analogs were tested for binding to the IgE receptor in cultured mast cells. Inhibitory activity of IgE-caused ...
From: [email protected] (Andy Nachbaur) Subject: bvemon faq Date: Thu, 10 Apr 1997 14:03:00 GMT Organization: WILD BEES BBS (209) 826-8107 LOS BANOS, CA To: [email protected] From: [email protected] (Darlene Scribilo) Subject: Bee Venom Therapy -FAQ Date: February 04, 1996 11:24 Hi Folks, I have found a very interesting article in the American Bee Journal, Vol. 136, No. 2, 1996, pp. 107-109, which I thought would interest you. It is on bee venom therapy and I have the permission of the author to post it here. Bee Venom - Frequently Asked Questions Bee venom therapy is becoming recognized and accepted for treating certain human ailments. Honey bee venom can be used in many different ways and forms. I receive dozens of letters from people who ask me to send all the information I have on bee venom. I answer all the letters, however, I am unable to send them all of my approximately 5,000 pages of literature. In order to help I have gathered the most frequently asked questions which I will ...
Abstract: Alcohol consumption increases apoptosis of hepatocytes. Death of hepatocytes is a characteristic feature of chronic liver disease for various causes. Bee venom (Apis mellifera) has been traditionally used for the treatment of various chronic diseases, such as chronic inflammatory arthritis and chronic liver disease. However, the precise mechanism for bee venom in chronic liver disease is not still cleared. To assess the effects of bee venom in chronic liver disease, we investigated the potential role of the bee venom in the ethanol-induced hepatocyte apoptosis. Bee venom treatment inhibited the apoptotic cell morphology and increased the cell viability in ethanol-induced hepatocyte apoptosis. With ethanol treatment, bee venom-treated hepatocytes increased activity of Bcl-2 and Bcl-xL, reduced activity of Bax, Caspase and PARP. In conclusion, bee venom treatment in ethanol-induced hepatocyte apoptosis occurred through the regulation of Bcl family with subsequent inactivation of the ...
TY - JOUR. T1 - Increased expression of osteopontin is associated with long-term bee venom immunotherapy. AU - Konno, Satoshi. AU - Golden, David B.K.. AU - Schroeder, John. AU - Hamilton, Robert G.. AU - Lichtenstein, Lawrence M.. AU - Huang, Shau Ku. PY - 2005/1/1. Y1 - 2005/1/1. N2 - Background: Venom allergen immunotherapy (VIT) is proven to be highly effective for insect allergy, but the mechanisms and the biomarkers associated with clinical efficacy remain elusive. Objective: The aim of this study was to identify candidate biomarkers associated with successful VIT. Methods: Gene chip array and clustering analyses of PBMCs from subjects with or without VIT were performed. Results: From gene chip array and clustering analyses, an increased expression of osteopontin was found in patients who completed 5 to 6 years of VIT and discontinued therapy for 3 to 6 years (completed treatment group) compared with the untreated group. A significantly higher level of serum osteopontin was found in the ...
Stings from bees or wasps produce a variety of clinical manifestations [1-7]. In cases of corneal bee sting discussed in the literature, corneal complications have been reported most frequently [2-4]. In all these cases, the corneal edema regressed and infiltrates resulted in a corneal scar 4 to 6 weeks after removal of the stinger and the initiation of treatment. Corneal edema has been explained by cell death caused by activation of the complement cascade by proteins in the bee venom, leading to the production of anaphylotoxins and chemotactic factors [1, 3]. Bee venom is a complex toxin having various impacts and components. It contains two types of biogenic amines: non-enzymatic polypeptide toxins (melittin, apamin, mast cell degranulating peptide) and enzymes (phospholipase A, phospholipase B, hyaluronidase). Ocular inflammation increases capillary protein permeability allowing greater leakage of proteins into the vitreous space.. The difference of wasp sting effects depends on the type of ...
Dr. Weeks Comment: The idea that honeybee venom offers anti-cancer properties seems implausible until one penetrates the very biochemistry of this remarkable and highly refined biologically active substance. I have worked intensively with apitherapy since co-founding the American Apitherapy Society with master Bee-keeper Charlie Mraz in the early 1980s. So enjoy the brilliant science that follows. "…Melittin is a major polypeptide in honey bee venom that has been used traditionally against chronic inflammation and cancer…" "…Apis mellifera venom consists of many biologically active molecules and has been reported to exhibit remarkable anti-cancer effects, often promoting an apoptosis-like death phenotype…" Environ Toxicol Pharmacol. 2013 Jun 28;36(2):697-705. doi: 10.1016/j.etap.2013.06.009. [Epub ahead of print]. Melittin: A lytic peptide with anticancer properties.. Gajski G, Garaj-Vrhovac V.. Source. Institute for Medical Research and Occupational Health, Mutagenesis Unit, 10000 ...
Some people swear by the therapeutic effects of bee venom therapy. This can consist of actual bee stings, bee venom applied in a cream,or bee venom taken in the form of tablets. Those with Lyme disease, M.S. symptoms, Chronic Fatigue Syndrome, Fibromyalgia...etc often report good results. Of course no one therapy works for everyone and people must decide what works best for them. For more information you can go to the following link ...
Bee venom and phospholipase A2 extracted from bee venom enhanced guanylate cyclase (E.C. 4.6.1.2) activity two- to threefold in rat liver, lung, heart, kidney, ileum, and cerebellum. Dose-response relationships revealed that bee venom at concentrations as low as 1 microgram per milliliter and phospholipase A2 at 1 microunit per milliliter caused a maximal enhancement of guanylate cyclase.. ...
Systemic Immediate Hypersensitive Reactions after Treatment with Sweet Bee Venom: A Case Report - anaphylaxis;bee venom;hypersensitivity reaction;sweet bee venom;systemic immediate;
Discover an anti-ageing skincare featuring a unique blend of Bee Venom, stem cells & award-winning peptide technology. Free delivery on all orders.Bee Venom
Researchers verified, in a pre-clinical model of the disease, that bee venom and one of its components, apamine, are able to stop or slow the loss of dopaminergic neurons, the neuronal cell type most severely affected in PD. They showed that regular bee venom injections are indeed able to slow the degeneration of dopaminergic neurons in the PD model used, and that this effect is partially due to apamine. However, the complete list of compounds responsible for this effect and the mechanism(s) of action remain to be characterized.. ...
The effects of mast cell degranulating peptide (MCDP), a toxin from the honey bee, and of dendrotoxin (DTX), a toxin from the green mamba snake, were studied in voltage-clamped experiments with myelinated nerve fibres of Xenopus. MCDP and DTX blocked part of the K+ current. About 20% of the K+ current, however, was resistant to the toxins even in high concentrations. In Ringer solution half-maximal block was reached with concentrations of 33 nM MCDP and 11 nM DTX. In high-K+ solution the potency of both toxins was lower. β-Bungarotoxin (β-BuTX), another snake toxin, also blocked part of the K+ current, but was less potent than MCDP and DTX. Tail currents in high-K+ solution were analysed and three K+ current components were separated according to Dubois (1981b). Both MCDP and DTX selectively blocked a fast deactivating, slowly inactivating K+ current component which steeply activates between E = -60 mV and E = -40 mV (component f1). In concentrations around 100 nM, MCDP and DTX blocked neither ...
Theres been a lot of talk about how bee venom is used in skincare to plump up and firm the skin. This is the low down - bee venom acts as an irritation as if it has been stung with the peptide Melittin. It causes an increased blood circulation to the deep layers of the skin and stimulates cell regeneration and the production of elastin and collagen to lift, plump and tighten the skin. This means that it can be used as a natural alternative to clinical treatments that involve painful needles ...
NatureBee Bee Venom Mask works by fooling the skin into thinking it has been gently stung. This then stimulates the body into producing naturally occurring chemicals collagen and elastin. The process is completely pain free and you may feel a slight tingling sensation. Immediately after application your skin will look and feel tighter. The effects of NatureBee Bee Venom Mask are cumulative. You will notice after longer use a more dramatic effect. For best results apply mask freshly cleansed neck and face and leave on overnight. The mask also works well applied as a cream first thing in the morning underneath make up.. *No bees were harmed in the making of this product. To extract the venom, a pane of glass is placed alongside the hive and a gentle electrical current is run through it, which harmlessly encourages the insects to sting the surface.. Slow down skin aging ...
Fifteen male Wistar rats were randomly divided into bee venom treatment group (BV group), CIA model group, and control group. In the former two groups, CIA was induced by injections of collagen II+IFA (0.2 mL) via the tail vein, and in the control group, normal saline was injected instead. The rats in BV group received daily injection of 0.1 mL (3 mg/mL) bee venom for 7 consecutive days. All the rats were assessed for paw thickness and arthritis index from days 14 to 21, and the pain threshold was determined on day 21. The expressions of TRPV1 and TrkA in the dorsal root ganglion at the level of L4-6 were detected using immunohistochemistry and Western blotting, respectively ...
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The researchers theorized that bee venom could be used to synthetically modify erroneous dopamine levels for people suffering from Parksinsons. Dopamine comprises 1.5 percent of apitoxin and is a neurotransmitter found in the human brain. Researchers hoped that treatment with bee venom could eliminate the adverse side effects of conventional anti-Parkinsonian medication, such as L-DOPA, which often include hypotension, arrhythmias, nausea, gastrointestinal bleeding, and disturbed respiration ...
Different bee venoms are on the market. I use the product VeneX, which comes in two different strengths: VeneX-10 and VeneX-20 (Table 1.). VeneX-20 is twice as concentrated as VeneX-10. VeneX-10 contains 1.0 mg of bee venom per 1.0 ml. A 0.1 ml of this solution delivers approximately the same amount of bee venom as a natural bee sting. The content of melittin in bee venom is dependent on where it is collected on the hive; the season and the pollen source the bees have access to at the time. Generally between one third and one half of the venom is melittin. Because of these variables the symptoms seen on administration of the venom can also vary. Bee venom is used for desensitization and is approved with the FDA for this purpose. There is an official monograph in the Homeopathic Pharmacopoea of the United States (HPUS), also recognized by the FDA ...
In the present study, to our knowledge, we first demonstrated that bvPLA2 is the major BV compound capable of inducing Treg expansion without altering the total composition of the other cell types in vivo and in vitro. Our previous report showed that BV has therapeutic effects on the MPTP-induced mouse model of PD via modulating the neuroinflammatory response and increasing the proportion of functional Tregs (23). In this study, we showed that bvPLA2 has neuroprotective effects by suppressing microglial activation and reducing the infiltrating CD4+ T cells in the MPTP-induced mouse model of PD. In addition to the neuroprotective effects, bvPLA2 directly binds to the mannose receptor (CD206) on DCs, and this binding induces the release of PGE2, which promotes Treg induction in CD4 T cells.. Microglia are resident innate immune cells of the CNS found in and around degenerating neurons (10-12) that are rapidly activated in response to neuronal damage and significantly contribute to secondary ...
Immunity. 2013 Nov 14;39(5):976-85. doi: 10.1016/j.immuni.2013.10.006. Epub 2013 Oct 24. Research Support, N.I.H., Extramural; Research Support, Non-U.S. Govt
Bee venom is a natural compound produced by the honey bee (Apis mellifera), and has been reported as having the biological and pharmacological activities, including anti-bacterial, anti-viral and anti-inflammation. In the present study, the inhibitory effects of bee venom and its major peptide components on the tumor invasion were demonstrated. It was confirmed the inhibitory effects of bee venom, melittin, and apamin on the EGF-induced invasion of breast cancer cells. Transwell invasion and wound-healing assays showed that bee venom and melittin significantly inhibits the EGF-induced invasion and migration of breast cancer cells. Also, bee venom and melittin reduced the EGF-stimulated F-actin reorganization at the leading edge, but apamin did not affect. Particularly, melittin inhibited the EGF-induced MMP-9 expression via blocking the NF-κB and PI3K/Akt/mTOR pathway. In addition, melittin significantly suppressed the EGF-induced FAK phosphorylation through inhibition of mTOR/p70S6K/4E-BP1 ...
Bee venom is a colorless liquid made up of proteins, enzymes, and soluble amino acids. It is one of the traditional folk remedies used....
Apamin is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom). Dry bee venom consists of 2-3% of apamin. Apamin selectively blocks SK channels, a type of Ca2+-activated K+ channel expressed in the central nervous system. Toxicity is caused by only a few amino acids, these are cysteine1, lysine4, arginine13, arginine14 and histidine18. These amino acids are involved in the binding of apamin to the Ca2+-activated K+ channel. Due to its specificity for SK channels, apamin is used as a drug in biomedical research to study the electrical properties of SK channels and their role in the afterhyperpolarizations occurring immediately following an action potential. The first symptoms of apitoxin (bee venom), that are now thought to be caused by apamin, were described back in 1936 by Hahn and Leditschke. Apamin was first isolated by Habermann in 1965 from Apis mellifera, the Western honey bee. Apamin was named after this bee. Bee venom contains many other compounds, like histamine, ...
Over the last few years bee researchers have found that bee venom has some of the most powerful anti - aging properties known to man. When correctly combined and used regularly, one can achieve youthful looking skin and a more plump look - voiding the need for expensive and often invasive surgeries.
A lightweight daily face moisturiser that re-densifies skins appearance with bee venom, melittin peptide, soy isoflavones and stemcells. Working to brighten skin tone, firm and plump wrinkle appearance and improve skin elasticity.
Bee venom can have a positive impact on your skin -- and a new line of skin care products is bringing those benefits to you without all the nasty stings.
Amyotrophic lateral sclerosis (ALS) is caused by the degeneration of lower and upper motor neurons, leading to muscle paralysis and respiratory failure. However, there is no effective drug or therapy to treat ALS. Complementary and alternative medicine (CAM), including acupuncture, pharmacopuncture, herbal medicine, and massage is popular due to the significant limitations of conventional therapy. Bee venom acupuncture (BVA), also known as one of pharmacopunctures, has been used in Oriental medicine to treat inflammatory diseases. The purpose of this study is to investigate the effect of BVA on the central nervous system (CNS) and muscle in symptomatic hSOD1G93A transgenic mice, an animal model of ALS. Our findings show that BVA at ST36 enhanced motor function and decreased motor neuron death in the spinal cord compared to that observed in hSOD1G93A transgenic mice injected intraperitoneally (i.p.) with BV. Furthermore, BV treatment at ST36 eliminated signaling downstream of inflammatory proteins
Bee Venom (BV) has long been used in Korea to relieve pain symptoms and to treat inflammatory diseases, such as rheumatoid arthritis. The underlying mechanisms of the anti-inflammatory and analgesic actions of BV have been proved to some extent. Additionally, recent clinical and experimental studies have demonstrated that BV and BV-derived active components are applicable to a wide range of immunological and neurodegenerative diseases, including autoimmune diseases and Parkinsons disease. These effects of BV are known to be mediated by modulating immune cells in the periphery, and glial cells and neurons in the central nervous system. This review will introduce the scientific evidence of the therapeutic effects of BV and its components on several immunological and neurological diseases, and describe their detailed mechanisms involved in regulating various immune responses and pathological changes in glia and neurons.
Therapeutic Effects of Bee Venom on Immunological and Neurological Diseases 새창 Abstract Bee Venom (BV) has long been used in Korea to relieve pain symptoms and to treat inflammatory diseases, such as rheumatoid arthritis. The underlying mechanisms of the anti-inflammatory and analgesic actions of BV have been proved to some extent. Additionally, recent clinical and experiment…. 최고관리자 쪽지보내기 메일보내기 자기소개 전체게시물 ...
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Learn about the potential benefits of Bee Venom including contraindications, adverse reactions, toxicology, pharmacology and historical usage.
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Ive purchased a Antiinflammatory Bee Venom Ointment, thought to add some in my facial creams and masks. However, it does not look like I can do that.
Skubida, P.; Muszynska, J.; Rybak, M.; Marcinkowski, J., 1995: Bee venom collection and its effect on the general output of the apiary and wintering
Benton - Snail Bee High Content Essence 60ml Snacil mucin supports natural cell regeneration and replenishes moisture to increase firmness, and bee venom has natural anti-inflammatory, anti-bacterial, and anti-viral properties. - The gel-like essence is also fragrance free! Best recommended for those with sensitive and troubled skin. - This product contains 90% snail extract and bee venom instead of water. - Powerful ingredients such as snail mucin and bee venom help to heal scars, brighten skin tone, and maintain hydration throughout the day.
TY - ABST. T1 - Differential effects of peripheral NMDA and non-NMDA receptors on response of persistent nociception induced by subcutaneous bee venom injection of the rat. AU - You, Hao-Jun. AU - Chen, J.. AU - Arendt-Nielsen, Lars. PY - 2001. Y1 - 2001. M3 - Conference abstract in proceeding. BT - International Advanced Workshop on Brain/Pain Research : From Molecules to Mind, 30 April-2 May 2001, Xian, China. ER - ...
Nip + Fab repairing Bee Sting Fix Toning Pads help the skin retain hydration. These cleansing facial pads contain bee venom. Free UK delivery on orders £10+
When bees sting, they pump poison into their victims. Now the toxin in bee venom has been harnessed to kill tumor cells by researchers at Washington University School of Medicine in St. Louis. The researchers attached the major component of bee venom to nano-sized spheres that they call nanobees.
Bee venom is in high demand, so lets find out how it is formed and how it is mined. The poison of bees arises as a result of the secretory function - the work of threadlike glands, in the stinging apparatus of the honey bee. It should be noted that the bee has two glands - large and small, one produces an acidic component of the poison, and the other - alkaline, which, when combined, enhance their action. The quantity and quality of the poison depends on the age of the bee, the characteristics of the diet, the time of the year. The poison in the glands of the bee accumulates with age, reaching the maximum reserves two weeks after its release from the wax cell. There are several ways how to collect bee venom: ...
Nanoparticles carrying a toxin found in bee venom can destroy human immunodeficiency virus (HIV) while leaving surrounding cells unharmed, researchers at Washington University School of Medicine in St. Louis have shown. The finding is an important step toward developing a vaginal gel that may prevent the spread of HIV, the virus that causes AIDS.. "Our hope is that in places where HIV is running rampant, people could use this gel as a preventive measure to stop the initial infection," says Joshua L. Hood, MD, PhD, a research instructor in medicine.. The study appears in the current issue of Antiviral Therapy.. Bee venom contains a potent toxin called melittin that can poke holes in the protective envelope that surrounds HIV, and other viruses. Large amounts of free melittin can cause a lot of damage. Indeed, in addition to anti-viral therapy, the papers senior author, Samuel A. Wickline, MD, the J. Russell Hornsby Professor of Biomedical Sciences, has shown melittin-loaded nanoparticles to be ...
Kate Middleton isnt the only royal creating a buzz with her beauty habits. Camilla, Duchess of Cornwall, reportedly slathers on a $90 bee venom-based face mask to combat the aging process. This organic face lift...
Sigma-Aldrich offers abstracts and full-text articles by [Sang Mi Han, Joung Min Kim, In Pyo Hong, Soon Ok Woo, Se Gun Kim, He Rye Jang, Sok Cheon Pak].
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HIV may be referred to as a slowly replicating virus that is capable of invading the human body by way of exchanging bodily fluids with another infected carrier. This invasion is said to be the primary culprit that causes the acquired immunodeficiency disease (AIDS), which may be at the top of the list as being one of the deadliest diseases known to mankind. Once the HIV virus has gained complete control over the human immune system, the expected survival span of the infected individual is presumed to be approximately seven to ten years. However, researchers seem to have an idea about how to increase this life expectancy for those who have been infected with the HIV. Ironically, a preventive measure could very well be found in something that has been flying over the heads of humanity for years.. At the Washington School of Medicine in St. Louis, Missouri, scientists have discovered an amazing aspect about the one insect most people may dread to see anywhere within close range. The idea of using ...
It is also important to note the debate surrounding HIV and AIDS. Findings suggest there is not solid scientific evidence that exists today to prove the existence of HIV. AIDS is also under great debate as in some countries it is considered to be one thing while in another, it is something totally different. One can literally be diagnosed with AIDS in one country but not in another. AIDS is often is simply a term for a HUGE umbrella of potential diseases. The only common factor found amongst definitions is if the bodys T-cell count reduces below a specific level. Why is there such a lack of distinction about what AIDS truly is? Why so many different definitions ...
Bee stings can cause a fatal reaction called anaphylaxis in people who have a severe allergy to bee venom. It is possible to have the same reaction to foods and medicines (peanuts and shellfish are also common causes of anaphylatic reactions). The effects are nearly immediate -- swelling of the neck and face, sweating, difficulty breathing and hives are among the most common signs. Many people with severe allergies, especially bee stings, carry a device called an Epi-Pen. An Epi-Pen is a dosage of a powerful hormone, epinephrine, which counteracts an anaphylactic reaction. To use it, remove the safety cap and simply press the needle end firmly against the victims thigh, about midway between the knee and hip. The spring-loaded needle will automatically extend, delivering the epinephrine into the muscle where it will be rapidly transferred into the bloodstream. The effect of the epi-pen is temporary, however, and the person must still get medical attention quickly.. ...
Thats what we are interested in - those are the cells responsible for metastasizing and also responsible for having the cancer cells grow back," Pan said. "If wecan target better using this technique, we potentially have a better cancer treatment.". Unlike chemotherapy, this more targeted technique would, in theory, only affect cancer cells. If its successful, this natural agent found in venom could become the basis for a whole legion of cancer-fighting drugs.. Pans research builds on a growing body of scientific research that has shown toxins in venom can fight cancer cells without harming healthy cells.. For example, Dr. Samuel Wickline at Washington University in St. Louis helped develop "nanobees" that are also being tested to see if they can deliver a synthesized version of the toxin found in bee venom to cancer cells in prostate cancer.. ...
Allergy shots (immunotherapy) are used to treat people who have hay fever (allergic rhinitis), conjunctivitis, or asthma. They are also used for people with a stinging insect allergy (bee venom allergy). A mixture of the many allergens to which you are allergic is made. It is injected into your arm on a weekly basis until a maximum dose is reached. Then the number of injections is decreased over time. Most people get better with allergy shots. It often takes about 12 to 18 months before you notice a clear reduction in symptoms. Some people see improvement in 6 to 8 months. Allergy shots are only part of the treatment plan for people with allergies. It takes time for allergy shots to become effective. So you will need to stay on the allergy medicines as prescribed by your healthcare provider. It is also important to keep allergens (such as dust mites) under control in your surroundings. A newer type of immunotherapy is called SLIT (sublingual immunotherapy). It can be taken by mouth daily at ...
Dr. Palumbo responded: Bee or Wasp allergy. Venom includes bees wasps hornets and fire ants. |a href="/topics/immunotherapy" track_data="{
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The Bureau of Labor Statistics reports 52 workplace deaths from bee stings between 2003 and 2010. On average over 50 people in the US die from sting allergies annually. Many more people are stung. Many people with allergies to stinging insects will carry an EpiPen in case of anaphylactic reaction. Beekeepers often keep an EpiPen in…
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Im going to flush your IV with saline and then give you some Valium [a muscle relaxant] for the muscle spasms," he said. But when he bent down to flush the IV, it felt as if my veins were being flooded with bee venom - a constant stinging sensation washed over my arm, and I startled so hard that Benny jumped too. He pressed on the IV tube lightly -- "Does this hurt?" YES - even gentle pressure was painful. He summoned another nurse to take a look at the IV, and they agreed that if a saline flush was this painful, the Valium (which is achy going in anyway) would be intolerable. (Im still not sure what was up with this IV, but it "traced" my veins with bruises...photo at the end if youre curious ...
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Although it has been previously reported that bee venom can inhibit human cancer cell growth through induction of apoptosis in many cancer cell lines such as prostate cancer, breast cancer and melanoma, there is no finding of the induction of apoptosis in human T cell acute lymphoblastic leukemia cells by BV [6-8]. Based on our knowledge, the present study is the first report about examination of the synergistic effect of BV with a palladium metal-based component.. Analysis of cytotoxicity by MTT assay proved that BV is both time- and dose-dependent in its cytotoxic effects, given that the Cc50 values of this component were 6.3 and 0.6 μg/mL after 24 and 48 hours, respectively. Due to the inconsistency in the MTT assay data - as a result of precipitation of the BV at high concentrations after 24 and 48 hours, and at low concentrations after 48 hours - only the concentrations less than 10 μg/mL were applied in these experiments. At these concentrations the findings were acceptable, except at 8 ...
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Apitherapy іѕ οftеn аƖѕο called bee therapy аnԁ іѕ tһе basically tһе uѕе οf bee products tο treat different conditions. Tһеrе аrе a number οf products tһаt саn һаνе health benefits аnԁ bе used іn apitherapy аnԁ tһеу include pollen, raw honey аnԁ royal jelly һοwеνеr tһе main one used іѕ bee venom. Tһе uѕе οf bee products аnԁ іn particular bee venom dates back tο ancient Greece, Egypt аnԁ China. In fact іt іѕ believed tһаt Hippocrates wһο іѕ considered tο bе tһе father οf medicine actually used bee stings tο treat people fοr conditions such аѕ arthritis. In addition іn 1888 Philip Terc published a paper οn bee venom аnԁ rheumatism. Today bee stings аrе used throughout tһе world аѕ a treatment fοr a wide variety οf different conditions аnԁ below wе wіƖƖ consider tһе benefits tһаt уοu сοuƖԁ ɡеt frοm tһе treatment ...
Insect venoms are complicated. Really complicated. You could be forgiven for thinking that it must be a relatively simple company of chemicals that makes up the painful sensation of a bee or wasp sting, but in fact a hugely complex mixture of all sorts of compounds - proteins, peptides, enzymes, and other smaller molecules - go into a small amount of venom. The range of compounds is far too vast to detail every single one - but we can examine some of the major constituents in bee, wasp, hornet and ant venom.. Well start with the venom about which we know the most - that of bees. Unlike many other insect venoms, we have a relatively good idea of the percentage breakdown of the venom of your average bee. When the bee stings, the venom is mixed with water, so the actual composition of the substance it injects into you is around 88% water and 12% venom. From this point onward, well consider the percentages of compounds purely in the venom itself.. The main toxic component of bee venom, also ...
VIT is globally accepted as the treatment of choice in venom allergy.15. Although 44 patients in the current study declared a negative effect of VIT on work, caused by changing working time and economic loss due to VIT, most of our participants declared an indifferent effect of VIT on work. Individuals at high risk of sting reported a positive VIT impact on work. This will support the accepted medical approach that occupation may influence the decision to initiate VIT, also for non-life-threatening reactions.5. Another predictor of a perceived positive effect from VIT was completion of treatment. Participants who have already completed VIT are probably more aware of the long-term beneficial effects of treatment. They are less likely to report any drawbacks of VIT, such as the time spent in therapy, which can affect work and social life. A relevant number of participants reported a negative impact of VIT on work and even if we could not find any peculiar characteristic of this group, this finding ...
Bee venom phospholipase A2 and the fluorescent probe merocyanine 540 were used to examine plasma membrane phospholipid organization in the spicules released by deoxygenation and reoxygenation of sickle red cells, as well as in reversibly and irreversibly sickled erythrocytes. Digestion of phosphatidyl ethanolamine in spicules was comparable to that of phosphatidyl choline, and these structures were stained by the fluorescent probe. Both assays suggest that membrane lipid asymmetry is disrupted in spicules. The residual cells, from which the spicules were derived, retain the normal asymmetry in phospholipid distribution between the outer and inner leaflets of the plasma membrane bilayer. Comparable experiments with cell fractions enriched in irreversibly sickled cells revealed a partial enhancement of phosphatidyl ethanolamine digestion, confirming the similar experiments of Lubin et al (1981). Staining of these cells with merocyanine 540, however, did not reveal a subfraction of stainable cells, ...
Tertiapin is a 21-amino acid peptide isolated from venom of the European honey bee (Apis mellifera). It blocks two different types of potassium channels, inward rectifier potassium channels (Kir) and calcium activated large conductance potassium channels (BK). Tertiapin is a peptidic component of the venom of the European honey bee (Apis mellifera). Tertiapin peptide is composed of 21 amino acids with the sequence: Ala-Leu-Cys-Asn-Cys-Asn-Arg-Ile-Ile-Ile-Pro-His-Met-Cys-Trp-Lys-Lys-Cys-Gly-Lys-Lys. The methionine residue is sensitive to oxidation, reducing the ability to block the ionic channels. Methionine can be substituted by glutamine in order to prevent the oxidation. The new synthesized peptide is named Tertiapin-Q and does not show any functional change as compared to the original peptide, which makes it a more suitable research tool. Tertiapin has been described as a potent potassium channel blocker, acting on two different types of K+ channels. Tertiapin binds specifically to different ...
Bee Legs and Stingers - Bee stings contain venom which destroys cells in an enemy’s body. Learn about bee stings and find out how the bee stinger is used for defense.
ARLINGTON HEIGHTS, ILL. - If you think summer insects are done setting their sights on ruining your outdoor gathering, think again. Augusts hot and dry climate is the perfect breeding ground for insects, especially yellow jackets. And for the millions of Americans allergic to insect stings, these late summer bugs can be deadly.. According to a report released today in the August issue of Annals of Allergy, Asthma & Immunology, the scientific journal of the American College of Allergy, Asthma and Immunology (ACAAI), insect sting allergy is increasing, affecting five percent of the population. But what much of the population may not understand is that there is something that can be done about it.. "While it does not always cure insect sting allergy, venom immunotherapy, a form of allergy shots, can almost always prevent severe reactions to stings," said David Golden, MD, article author and ACAAI fellow. "It usually provides long-lasting immunity even after the treatment is stopped.". Even 10 to ...
Vice-president of the newly re-structured board and president of the association Gagan Deep Singh said that in India the focus is on production of honey alone and other products like bee venom and royal jelly are being ignored. Citing examples of other countries, he said that they are earning huge profits from these two products. Gagan pointed out that bee venom was being used for manufacturing medicines for joint pains and royal jelly was being used for vitality increasing medicines. He said that the newly re-structured National Bee Board would now start exploring both these products as a part of bee keeping ...
I have been trying bee venom ointment(Venex) for a week now and am very excited at the improvement. It may be that the ointment will have to be used continually but maybe there will be an accumulative effect. I also just ordered a type of manuka honey called Actiflex. This also has bee venom in it but you take it orally. It is supposed to also help with the pain issues. From what I understand....you can find out more at the links below.....there is a substance in venom called mellitin. The Rocky Mountain Lab studied this substance a bit and found that it immobilized lyme disease spirochetes. It also helps stimulate the bodys immune system and is supposed to have 10 to 100 times the anti-inflammatory capability...over ...
Vascular dementia (VaD) is caused by the reduction of blood supply by vessel occlusion and is characterized by progressive cognitive decline. VaD incidence has been growing due to the aging population
So, courtesy of my first-ever bee sting and notes from my first aid and emergency care class in chiropractic school from the mid-90s, some thoughts to keep in mind in case you or a loved one is stung by a bee:. If youre stung by a honey bee, try to find the stinger. Honey bees dont always leave their stingers behind, but they often do. The sooner you get a stinger out, the less youll suffer. If youre able to locate the stinger, take the edge of a firm surface, like a credit card or even a finger nail and try to brush or scrape the stinger off. Stingers shouldnt be removed with forceps or with a pinch of your fingers because compressing the attached sac of venom is likely to worsen the injury. If you can see the end of the stinger but cant access it, try using a fingernail to press down into your skin about half an inch away - sometimes, this will allow the tissues surrounding the stinger to relax a bit and allow the stinger to rise enough to scrape it away (this is a commonly used ...
There are also a couple of variations on wasps: hornets, which are larger and have black and white rings instead of black and yellow; and yellow jackets, which closely resemble wasps but nest underground instead of above ground. Like wasps, hornets and yellow jackets can sting multiple times. Their venom (and honeybee venom) can be deadly for those with allergies (and not exactly pleasant for those without).. Also, lets not forget about the other type of bee-the bumblebee. They may have the cutest name, but youll know one when you see one by the fact that its absolutely huge, very loud in flight, and capable of inducing panic attacks in otherwise rational adults. They have black and yellow stripes and pollinate like honeybees-but like wasps and their cousins, bumblebees can sting you as many times as they like. ...
|Not only making a bee sting pain, swelling, and hot-cold body. If the sting carried out at certain points by people who know, some diseases, like rheumatism, high blood pressure, asthma can be cured. But do not try to sting if hiperalergi or suffering from complications of chronic heart failure, and liver, because it can be fatal. What…
For most people, an insect sting only causes redness, swelling and itching. However, for patients with allergies to these insects, insect venom can cause severe life-threatening reactions. An allergic reaction to an insect sting can involve your whole body and can start very rapidly after you are stung. Possible symptoms include dizziness, nausea, weakness, stomach cramps, diarrhea, hives, itching, or wheezing.
Each episode resulted from several stings by more than one ant. This behavior is typical of fire ants, which will sting repeatedly until removed [3]. The first episode resulted in a local cutaneous reaction with erythema. The second episode resulted in the formation of a 1-cm bulla, lasting for a week and leaving a permanent scar. The third episode was systemic, with the development of a body rash, a feeling of faintness, tachycardia, and shortness of breath, and occurred within 15 minutes of the stings. Fortunately, an oral dose of diphenhydramine hydrochloride, 50 mg, caused the symptoms to resolve. The last episode resulted in two bullae of smaller size ...
Case Reports: Here we describe three cases of massive bee envenomation, two of which were in geriatric patients. All patients were documented to have over 100 stings, with the highest one being a case of an 83 year old envenomated by over 400 Africanized honey bees (AB). All patients seemed to do well with supportive medical care, and were discharged from the hospital after 3-6 days of observation. The two geriatric patients were given epinephrine in the field and both had an increase in their Troponin I levels. It was not clear if this rise in Troponin I was an effect of epinephrine itself or a direct effect of the bee venom. Both geriatric patients were observed the longest in their Troponin I, and were released without any sequelae. Except for cases of anaphylaxis, we believe that these three cases show that supportive care is sufficient for patients with massive bee envenomation (over 100 stings ...
1) A life-threatening allergic reaction characterized by a swelling of body tissues including the throat, difficulty in breathing, and a sudden fall in blood pressure. (2) A widespread and very serious allergic reaction. Symptoms include dizziness, loss of consciousness, labored breathing, swelling of the tongue and breathing tubes, blueness of the skin, low blood pressure, heart failure, and death. Immediate emergency treatment is required for this type of shock, including administration of antivenom in the case of bee or wasp stings. (3) A sudden, life-threatening allergic reaction, characterized by dilation of blood vessels with a sharp drop in blood pressure and bronchial spasm with shortness of breath. Anaphylactic shock is caused by exposure to a foreign substance, such as a drug or bee venom, to which the individual has been previously exposed. The substances act as antigens, provoking a preliminary immune response during the first exposure that results in a full-blown, immediate response ...
For most individuals, insect stings cause immediate local reactions at the sting site and produce a temporary discomfort of redness, pain, itching and swelling lasting only a few hours. A large local reaction may be more painful with itching and swelling at the sting site and in surrounding areas that may last for a few days. For these latter two reactions, local skin care and occasionally oral antihistamines, corticosteroids and perhaps antibiotics may be required for relief. These reactions, however, do not necessitate venom skin testing and/or desensitization injections with venom extracts ...
Serum IgG and IgG subclass antibody testing have been proposed as methods of identifying levels of sensitivity to various allergens, but there is disagreement in the medical community about how effective IgG antibody testing is for this purpose.. After evaluating the clinical literature, Harvard Pilgrim has found that while there is evidence to support the medical necessity of IgG testing for venom immunotherapy, there is not sufficient clinical evidence to support its use for other conditions, such as food allergy. As a result, effective July 1, 2014, Harvard Pilgrim will cover IgG and IgG subclass allergen testing for venom immunotherapy only. For more information, please refer to the Serum IgG Allergy Testing Medical Policy.. ...
We meet Jennifer Rubin as Janice Starlin, the aging owner of a cosmetics firm. She has ALWAYS been the model spokeswoman for her company, but now shes a little too wrinkled and elderly to carry this post on, or so her fellow owners think (including the delightfully smarmy Gerritt Graham). So Janice learns of a doctor (played quite woodenly by Daniel J. Travanti) who has found that using a serum made from bee venom can make one younger. He experiments on a little kitty cat he finds in the alley and lo and behold, the cat gets younger, not to mention the fact that the poor puss also turns into a beecat!!! Anyway, Rubin uses the serum and voila, shes young and beautiful again, but also has advanced cases of paranoid delusions, and oh, yes, when she gets really horny, she turns into the titular monstrosity. The movie is a true B movie, and captures the feel of those wonderfully overwrought films of the 50s. Rubin is effective as the wasp woman; Doug Wert as her main hunk Alec is heroically adroit; ...
Learn from this womans story about Lyme disease symptoms, pathology, and treatment, including Bee Venom Therapy. It could save a life!
I hope everyone had a nice summer. What are some of the perils/ dangers assoicated with the summer months that are most hazardous to you? For me #1 yellow jacket stings, I never know something that small can actually kill me, Im big time allergic. I know someone who died of an anaphylactic shock post bee sting #2 Sun- freckles arent that cute, they are giant melanocytes -| sun damage. #3 - others - the poison ivy - oak etc -| allergic reactions again PS: I mean bee sting
For most children, the reaction to a sting is short-lived, with redness and swelling followed by pain and itching. For others, however, the allergic reaction to an insect sting can be life threatening.
When it becomes warm again in spring and the first blossoms and bushes begin to bloom, the bees also begin to swarm. There is a lot to tell about bees that is worth knowing and is exciting and interesting.. Like ants and wasps, bees belong to the order of hymenoptera ("membrane-winged"). The bee family is divided into honeybees and bumblebees. It is especially interesting that bees live together in a large colony. There is a queen bee, and she is the only bee that lays eggs, from which the offspring are hatched. Besides a few males (the so-called drones), a bee colony consists primarily of female worker bees that have different tasks. During her life, a worker bee repeatedly takes on new tasks, depending on her age. At the beginning of her life, a bee looks after the honeycomb cells and prepares them for the queens eggs. She then becomes a nurse bee and feeds the larvae (= bee babies) with nectar. Later she can then produce wax with the glands on her posterior and build honeycombs. There are ...
Guides through decision to take shots for insect sting allergies. Describes different types of allergic reactions. Includes how allergy shots work. Covers benefits and risks. Includes an interactive tool to help you make your decision.
Another name for Allergy to Insect Stings is Allergic Reactions. Home care for an allergic rash includes: * Avoid contact with the substance that caused ...
Do you have any meat tenderizer? My nephew got stung by a wasp and I put the tenderizer on a wet paper towel and then on top of the sting and it took the pain and itch out of it. Try it, it cant hurt. Also try soaking it in baking soda in warm water. Mix the soda up until it is a paste and put it on the finger and see if that helps. Baking soda works for chicken pox and measles ...
The best way to prevent bee stings is to keep your dog away from bees, but this is sometimes easier said than done. Pay attention to your dogs movements outside, and be especially alert if you see him snapping or biting at the air since he may be chasing a bee with his mouth. Locate flowering plants and shrubs that attract bees away from the dog-friendly parts of your yard or garden, and keep your lawn trimmed and weed-free to avoid accidental bee encounters. Promptly remove any bee or wasp nests that you find on your property, and look both high and low when conducting your nest search, as some species of hymenoptera favor ground nests instead of nests in trees or house eaves. Discuss the possibility of having emergency medications like epinephrine on hand to administer to your dog in the event he is stung in the future. Your veterinarian can prescribe an Epi-pen, which is an injectable dose of epinephrine, and he or she can instruct you in its use. ...
Eventbrite - Borders Beekeepers Association presents Border Beekeepers Winter Course - Sunday, 9 February 2020 at Kelso High School, Kelso, Scottish Borders. Find event and ticket information.
Allergists are warning of a shortage of a little-known product - honeybee, hornet and wasp venom extracts used in shots that prevent life-threatening reactions.
There is nothing like walking your dog on a lazy, warm summer evening. Kids are playing, the flowers are blooming, bees are stinging. Yes, you read that correctly, the bees are stinging! Ouch. Not only do humans suffer from bee stings, dogs do too!...
This jacket as a part of beekeepers suit has 3 layers of netting for ventilation to keep you cool and comfortable. Perfect for taking care of your hive. Shop now!
This is the official group for the mid york beekeepers club of central New York.for the discusion of club news and other beekeeping info.
When bees sting, they pump into their victims a peptide toxin called melittin that destroys cell membranes. Now, by encapsulating this extremely potent molecule within a nanoparticle, researchers at the Washington University ...
Most medicines cant get through the blood-brain barrier, but certain peptides in animal venoms can navigate across it to inflict damage. Now, researchers are capitalizing on venomous sneak attacks by developing a strategy based on a bee-venom peptide, apamin, to deliver medications to the brain. The researchers will present their work today at the 253rd National Meeting & Exposition of the American Chemical Society.
LATOXAN, the leading world supplier of venoms, created KITOXAN®, the first Libraries of venom fractions, to give a facilitated access to venom molecules and allow the effective activity screening of these natural compounds. Despite their promising future in Pharmaceuticals, Crop Science or Cosmetics most of them are still unknown. Because pure venoms are made of hundreds of active molecules, and because they contain some cytotoxic enzymes that prevent the use of ex vivo activity screening methods. the hit identification was arduous.. ...
Most recently there have been other losses, more hair, muscle strength and flexibility. I had been vigorously engaged in an exercise routine up until the beginning of this year, when I came down with a nasty cold. That was followed by the flu, then another cold, and then cancer brought out its secret weapon... GVHD. This is where the hair was lost, though not from my head. You might not think this a really big deal, but when you have to shower every day and you feel smooth skin where there once was a forest of hair, it acts as a constant reminder of what has been lost. Couple that with sore muscles and tight joints that dont bend as far as they once did, and those seemingly little things begin to pile up. One bees sting isnt much to most people, but when accompanied by a thousand of his little bee friends, suddenly even the stoutest, strongest warrior can be laid low. These may only be small things to the outside world, but in my head theyre a constant reminder that I no longer have that ...
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I had to modify my original ICU setup before the bees found the entrance. The aluminum tube was long and dark at first. I put a bend in it to act as a heat trap. I though it important since the cold air would otherwise flow over the little cluster. The bees never ventured into it to find the light at the end of the tunnel. So i shortened it and made it a straight shot directly to the entrance. 2 days went by and no effect. Last night i stuck a row of nail holes into the top ridge of the tube. Then put the shop lamp directly over these holes. Now with light streaming into the hive from the entrance tube I believe the bees saw the light and followed it out ...
Tamara Wolfson ~ Acupuncture Clinic ~ Apitherapy ~ Bee Venom Therapy ~ Arthritis, Bursitis, Tendinitis, Lyme Disease, Surgical scars, MS, Lupus, Shingles, Bells Palsy, Mood Disorders, Fibromyalgia, Raynauds Disease, Chronic Fatigue, Herniated Discs, N
Treatment failure during venom immunotherapy (VIT) may be associated with a variety of risk factors. Our aim was to evaluate the association of baseline serum tryptase concentration (BTC) and of other parameters with the frequency of VIT failure during the maintenance phase. In this observational prospective multicenter study, we followed 357 patients with established honey bee or vespid venom allergy after the maintenance dose of VIT had been reached. In all patients, VIT effectiveness was either verified by sting challenge (n = 154) or patient self-reporting of the outcome of a field sting (n = 203). Data were collected on BTC, age, gender, preventive use of anti-allergic drugs (oral antihistamines and/or corticosteroids) right after a field sting, venom dose, antihypertensive medication, type of venom, side effects during VIT, severity of index sting reaction preceding VIT, and duration of VIT. Relative rates were calculated with generalized additive models. 22 patients (6.2%) developed ...
The development of iron granules in honey-bee tissues was investigated using both anatomical and analytical methods. Iron granules are present only in the trophocytes of post-eclosion adults and have the same elemental composition as those in foraging adults. The granules increase in both size and number during ageing. Iron levels in developing worker honey-bees were measured by proton-induced X-ray emission spectroscopy. The rate of iron accumulation was directly related to iron levels in the diet, and the iron can be obtained from pollen and honey, both major food sources of the bee. In adults, the iron content of the fat body reached a maximum level (2.4 +/− 0.15 micrograms mg-1 tissue), regardless of the amount of iron available for ingestion. Maximal iron levels are reached at the time when honey-bee workers commence foraging behaviour, suggesting that iron granules may play a role in orientation. Alternatively, accumulation of iron in granules may be a method of maintaining iron ...
I was wondering if anyone else had a real problem with bee stings, and poison ivy? I think that I have read about atopic dermatitis ...
The results in Table 4 clearly show the strong anti-lethal activity of LTNF identified in opossum serum. LTNF is effective in neutralizing the effect of venoms when given half an hour before or after venom injection. The anti-lethal activity of LTNF was exhibited when it was administered half an hour before venom injection, therefore, it can be used as a preventive measure, especially for snake handlers, etc.. After injecting the predetermined lethal dose of toxins derived from animals, plants, and bacteria, the mice were given 200µg of LTNF in 0.5 ml volume by IP route. The control mice were given 0.5 ml PBS. The results are shown in Table 5.. The results in Table 5 show that TNF neutralizes the lethal toxic effects of various snake venom toxins: crotoxin, cobratoxin, PLA2, and, the most potent taipoxin. Furthermore, LTNF neutralizes the lethal effects of ricin, one of the most toxic plant-derived toxins, and also the bacterial toxins botulinum and holothurin.. DISCUSSION. Snakebite continues ...
The action of purified phospholipases on monomolecular films of various interfacial pressures is compared with the action on erythrocyte membranes. The phospholipases which cannot hydrolyse phospholipids of the intact erythrocyte membrane, phospholipase C from Bacillus cereus, phospholipase A2 from pig pancreas and Crotalus adamanteus and phospholipase D from cabbage, can ... read more hydrolyse phospholipid monolayers at pressure below 31 dynes/cm only. The phospholipases which can hydrolyse phospholipids of the intact erythrocyte membrane, phospholipase C from Clostridium welchii phospholipase A2 from Naja naja and bee venom and sphingomyelinase from Staphylococcus aureus, can hydrolyse phospholipid monolayers at pressure above 31 dynes/cm. It is concluded that the lipid packing in the outer monolayer of the erythrocyte membrane is comparable with a lateral surface pressure between 31 and 34.8 dynes/cm. show less ...
Always Watching is billed as Romantic Suspense, but one thing I loved about it was that the romance did not get in the way of the story line. Olivia and Wade were attracted to each other from the beginning, but the challenge of keeping him and his family safe, and finding the stalker, took precedence over initiating a romantic relationship. Anyone who enjoys mystery, suspense, or police dramas, men or women, will enjoy this book. This is the first book of the Elite Guardians series, and the first book Ive read by this author. I am really looking forward to the rest of this series ...

Bee Venom FAQBee Venom FAQ

2. Does venom collection kill bees? Bee venom can be collected without killing bees. During the 1950s and 1960s, venom ... Freeze-drying is perhaps the most effective method of preserving bee venom. 4. What is bee venom used for? Bee venom is a rich ... It is on bee venom therapy and I have the permission of the author to post it here. Bee Venom - Frequently Asked Questions Bee ... 8. Is bee venom solution as effective as bee stings? Bee venom has many active components, however, during its collection it ...
more infohttp://www.ibiblio.org/pub/academic/agriculture/entomology/beekeeping/general/venom_therapy/bevenfaq.html

Bee venom enhances guanylate cyclase activity | ScienceBee venom enhances guanylate cyclase activity | Science

Bee venom and phospholipase A2 extracted from bee venom enhanced guanylate cyclase (E.C. 4.6.1.2) activity two- to threefold in ... Dose-response relationships revealed that bee venom at concentrations as low as 1 microgram per milliliter and phospholipase A2 ...
more infohttp://science.sciencemag.org/content/213/4505/359

Bee Venom as a Neuroprotective Agent in Parkinsons Disease | Parkinsons DiseaseBee Venom as a Neuroprotective Agent in Parkinson's Disease | Parkinson's Disease

Bee venom injections are used for desesentization treatments against allergies to bee venom. Usually, patients are injected ... This study would pave the way for a first clinical trial, which would be fairly easy to organize since bee venom injections are ... These researchers wish to know whether bee venom and/or its constituent, apamine, are able to slow or halt the disease process ... Researchers verified, in a pre-clinical model of the disease, that bee venom and one of its components, apamine, are able to ...
more infohttps://www.michaeljfox.org/foundation/grant-detail.php?grant_id=462

The Protective Effect of Bee Venom against Ethanol-Induced Hepatic Injury via Regulation of the Mitochondria-Related Apoptotic...The Protective Effect of Bee Venom against Ethanol-Induced Hepatic Injury via Regulation of the Mitochondria-Related Apoptotic...

To assess the effects of bee venom in chronic liver disease, we investigated the potential role of the bee venom in the ethanol ... Bee venom (Apis mellifera) has been traditionally used for the treatment of various chronic diseases, such as chronic ... With ethanol treatment, bee venom-treated hepatocytes increased activity of Bcl-2 and Bcl-xL, reduced activity of Bax, Caspase ... Woo-Ram Lee, Sok Pak, Kwan-Kyu Park, The Protective Effect of Bee Venom on Fibrosis Causing Inflammatory Diseases, Toxins, 2015 ...
more infohttp://onlinelibrary.wiley.com/doi/10.1111/j.1742-7843.2010.00549.x/abstract

The Lyme Disease Sentinel Blog: Bee Venom Therapy For Lyme DiseaseThe Lyme Disease Sentinel Blog: Bee Venom Therapy For Lyme Disease

This can consist of actual bee stings, bee venom applied in a cream,or bee venom taken in the form of tablets. Those with Lyme ... Some people swear by the therapeutic effects of bee venom therapy. ...
more infohttp://lymesentinel.blogspot.com/2009/01/bee-venom-therapy-for-lyme-disease.html

Systemic Immediate Hypersensitive Reactions after Treatment with Sweet Bee Venom: A Case Report | Korea ScienceSystemic Immediate Hypersensitive Reactions after Treatment with Sweet Bee Venom: A Case Report | Korea Science

... bee venom;hypersensitivity reaction;sweet bee venom;systemic immediate; ... Systemic Immediate Hypersensitive Reactions after Treatment with Sweet Bee Venom: A Case Report - anaphylaxis; ... The case report an anaphylaxis occurred when using sweet bee venom and common bee venom at the same time]. J Pharmacopuncture. ... Although hypersensitivity reactions due to sweet bee venom (SBV) have been reported, SBV has been reported to be associated ...
more infohttp://www.koreascience.or.kr/article/ArticleFullRecord.jsp?cn=DHOCBS_2015_v18n4_59

Increased expression of osteopontin is associated with long-term bee venom immunotherapy<...Increased expression of osteopontin is associated with long-term bee venom immunotherapy<...

Increased expression of osteopontin is associated with long-term bee venom immunotherapy. In: Journal of Allergy and Clinical ... Increased expression of osteopontin is associated with long-term bee venom immunotherapy. / Konno, Satoshi; Golden, David B.K ... Increased expression of osteopontin is associated with long-term bee venom immunotherapy. Journal of Allergy and Clinical ... title = "Increased expression of osteopontin is associated with long-term bee venom immunotherapy", ...
more infohttps://tmu.pure.elsevier.com/en/publications/increased-expression-of-osteopontin-is-associated-with-long-term-

Bee sting - WikipediaBee sting - Wikipedia

In one of the alternative medical uses of honey bee products, apitherapy, bee venom has been used to treat arthritis and other ... A bee sting is a wound caused by the stinger from a bee (honey bee, bumblebee, sweat bee, etc.) being injected into ones flesh ... Bee venom is acidic, and these interventions are often recommended to neutralize the venom; however, neutralizing a sting is ... Drone bees, the males, are larger and do not have stingers. The female bees (worker bees and queens) are the only ones that can ...
more infohttps://en.m.wikipedia.org/wiki/Bee_sting

Ondansetron combined with ST36 (Zusanli) acupuncture point injection for postoperative vomiting | Acupuncture in MedicineOndansetron combined with ST36 (Zusanli) acupuncture point injection for postoperative vomiting | Acupuncture in Medicine

Bee venom attenuates neuroinflammatory events and extends survival in amyotrophic lateral sclerosis models. J Neuroinflammation ... Recently, increased interest has been shown in using a multimodal approach with combined agents to treat PONV.3 Acupuncture and ... 21 ST36 acustimulation in patients undergoing chemotherapy has been reported to have an antiemetic effect.22 ,23 Few randomised ...
more infohttp://aim.bmj.com/content/early/2014/01/17/acupmed-2013-010340

Successful treatment of corneal wasp sting-induced panuveitis with vitrectomy | Journal of Ophthalmic Inflammation and...Successful treatment of corneal wasp sting-induced panuveitis with vitrectomy | Journal of Ophthalmic Inflammation and...

Corneal edema has been explained by cell death caused by activation of the complement cascade by proteins in the bee venom, ... Various cases describing corneal bee or wasp stings have been reported. Wasp venom contains up to 13 different antigens. ... Stings from bees or wasps produce a variety of clinical manifestations [1-7]. In cases of corneal bee sting discussed in the ... The difference of wasp sting effects depends on the type of wasp venom involved and whether the venom was injected into the eye ...
more infohttps://joii-journal.springeropen.com/articles/10.1186/1869-5760-3-18

About Honey BeesAbout Honey Bees

When a bee stings, its stinger and attached venom sac is torn from her abdomen, and she will die shortly afterward. Honey bees ... The Three Bees There are different types of bees in a honey bee hive: Worker, Drone and Queen. Each has its own important roles ... An attached muscle continues to pump venom through the stinger, even after it has been disconnected from the bee. For this ... Queen bees also produce a pheromone known as queen substance. This mixture of chemicals is passed individually from bee to bee ...
more infohttps://uaex.edu/farm-ranch/special-programs/beekeeping/about-honey-bees.aspx

Role of kinins and sensory neurons in the rat pleural leukocyte migration induced by Phoneutria nigriventer spider venomRole of kinins and sensory neurons in the rat pleural leukocyte migration induced by Phoneutria nigriventer spider venom

The leukocyte migration induced by Phoneutria nigriventer spider venom (PNV) has been investigated in rats using the pleurisy ... Role of kinins and sensory neurons in the rat pleural leukocyte migration induced by Phoneutria nigriventer spider venom. Autor ... Role of kinins and sensory neurons in the rat pleural leukocyte migration induced by Phoneutria nigriventer spider venom. ... the neurokinin NK1 receptor antagonist SR140333, but not the NK2 receptor antagonist SR48968, reduced by 55% venom-induced cell ...
more infohttp://repositorio.unifesp.br/handle/11600/26750

Get The Best Solution From Bee Removal EdmontonGet The Best Solution From Bee Removal Edmonton

This bee gives honey to people. Stinger and venom sac typically remain embedded in the skin of the victim. Bumble bee, hornets ... Way to control bees. various types of bee are living in this world. Some bee provides more benefits to peoples. Among them most ... Various type of bees are available, they are honey bees, hornets, wasps and yellow jackets. These different types of bees are ... The most common properties of bees are bite. If anybody disturbed, the bees will bite them. If bees bite your skin, then skin ...
more infohttp://www.dutchhouserental.com/get-the-best-solution-from-bee-removal-edmonton.html

The amino acid sequence of a myotoxic phospholipase from the venom of Bothrops asperThe amino acid sequence of a myotoxic phospholipase from the venom of Bothrops asper

A myotoxic, basic phospholipase A2 (pI greater than 9.5) with anticoagulant activity has been purified from the venom of ... The amino acid sequence of a myotoxic phospholipase from the venom of Bothrops asper. ... a phospholipase A2 presynaptic neurotoxin from Vipera ammodytes ammodytes venom. Hydropathy profiles of B. asper phospholipase ...
more infohttp://www.kerwa.ucr.ac.cr/handle/10669/29162

Cytotoxic Effect of Snake (Echis Carinatus) Venom on Human Embryonic Kidney Cells (HEK 293) | ClinMed International LibraryCytotoxic Effect of Snake (Echis Carinatus) Venom on Human Embryonic Kidney Cells (HEK 293) | ClinMed International Library

This work investigated the in vitro effect of Echis Carinatus crude venom, using cultured Human embryonic kidney (HEK 293) mono ... layers as a model to see the cytotoxic effect of Echis carinatus venom. ... carinatus venom cytotoxicity, we examined plasma membrane integrity. Because SVMP have been shown to induce plasma mem¬brane ... lebetina crude venom on the HUVEC, Bothrops moojeni crude Venom on MDCK and Russells viper venom on human A549 cells were ...
more infohttps://clinmedjournals.org/articles/cmrcr/clinical-medical-reviews-and-case-reports-cmrcr-3-132.php?jid=

The molecular basis of cross-reactivity in the Australian Snake Venom Detection Kit (SVDK)<...The molecular basis of cross-reactivity in the Australian Snake Venom Detection Kit (SVDK)<...

abstract = "The Snake Venom Detection Kit (SVDK) is of major medical importance in Australia, yet it has never been rigorously ... N2 - The Snake Venom Detection Kit (SVDK) is of major medical importance in Australia, yet it has never been rigorously ... AB - The Snake Venom Detection Kit (SVDK) is of major medical importance in Australia, yet it has never been rigorously ... The Snake Venom Detection Kit (SVDK) is of major medical importance in Australia, yet it has never been rigorously ...
more infohttps://research.monash.edu/en/publications/the-molecular-basis-of-cross-reactivity-in-the-australian-snake-v

Bee Venom.. the Good and the BadBee Venom.. the Good and the Bad

He started out allergic to bee stings and overcame the dangerous allergy. Learning about how to tolerate bee stings is part of ... Tags: BeeWeaver, beekeeping, stings, bee stings, Africanized bees, bee basics, keeping bees, bee sting allergy, anaphylactic ... I was sensitized to bee proteins and my immune system was primed to mount a full court press against bee venom. The result was ... I was born the son of a beekeeper, who was a son of beekeeper, who was a son of beekeeper, who was….. Anyway, the bee venom ...
more infohttps://www.motherearthnews.com/homesteading-and-livestock/bee-venom-the-good-the-bad

Bee Venom Body SerumBee Venom Body Serum

... Day and night body serum to help nourish and lift the appearance of skin with retinol and bee venom ... Day and night body serum to help nourish and lift the appearance of skin with retinol and bee venom melittin peptide. An ... Key benefits: melittin peptide: bee venom plumps and firms wrinkle appearance slow release retinol: to resurface and improve ... Bee Venom, Disodium EDTA, Tocopherol , Laureth-7, Lecithin, Retinol, Dehydroacetic Acid, BHT, BHA, Alpha-Isomethyl Ionone, ...
more infohttps://www.planetbeauty.com/rodial-bee-venom-body-serum

Bee venom: The key to healthy, youthful skin?Bee venom: The key to healthy, youthful skin?

Bee venom can have a positive impact on your skin -- and a new line of skin care products is bringing those benefits to you ... Bee Venom Moisturiser (Nordstrom, $190). Bee Venom Moisturiser is an advanced formula that uses bee venom, plant stem cells and ... on bee venom. Would you let a bee sting you on purpose? Probably not, but apparently bee venom can have a positive impact on ... Bee Venom Eye (Nordstrom, $140). Bee venom works in synergy with plant stem cells to help visibly improve skin tone and ...
more infohttp://www.sheknows.com/beauty-and-style/articles/1004291/bee-venom-the-key-to-healthy-youthful-skin

Bee Venom Therapy - Grassroots Medicine - Science-Based MedicineBee Venom Therapy - Grassroots Medicine - Science-Based Medicine

... honey bee venom had no beneficial effect against the course of EAE, and some of the mice treated with bee venom experienced a ... Preliminary Test Results Of Bee Venom In Mice With Ms-Like Disease May 8, 1998. They studied the effect of bee venom on mice ... a worse course of disease after receiving honey bee venom raises possible safety concerns for the use of honey bee venom ... by allowing bees to sting her. She calls this bee-venom therapy (BVT) and believes it has saved her from MS. ...
more infohttps://sciencebasedmedicine.org/bee-venom-therapy-grassroots-medicine/

Bee Venom Eye | Skincare | RodialBee Venom Eye | Skincare | Rodial

... brighten dark circles and firm the skin with bee venom, stem cell technology and melittin peptide. ... brighten dark circles and firm the skin with bee venom, stem cell technology and melittin peptide. Bee venom stimulates blood ... brighten dark circles and firm the skin with bee venom, stem cell technology and melittin peptide. Bee venom stimulates blood ... Bee Venom.. Cautions: Do not use if you have an allergy to bee stings. A patch test prior to use is recommended. If signs of ...
more infohttps://www.rodial.co.uk/skincare/products/eyes/bee-venom-eye

Bee Venom Eye | Skincare | RodialBee Venom Eye | Skincare | Rodial

... brighten dark circles and firm the skin with bee venom, stem cell technology and melittin peptide. ... brighten dark circles and firm the skin with bee venom, stem cell technology and melittin peptide. Bee venom stimulates blood ... brighten dark circles and firm the skin with bee venom, stem cell technology and melittin peptide. Bee venom stimulates blood ... Bee Venom.. Cautions: Do not use if you have an allergy to bee stings. A patch test prior to use is recommended. If signs of ...
more infohttps://www.rodial.co.uk/skincare/concerns/lines-wrinkles/bee-venom-eye

Bee Venom Uses, Benefits & Dosage - Drugs.com Herbal DatabaseBee Venom Uses, Benefits & Dosage - Drugs.com Herbal Database

Learn about the potential benefits of Bee Venom including contraindications, adverse reactions, toxicology, pharmacology and ... Experimental injection of bee venom caused a reaction similar to that observed in patients with bee venom-induced ARF. 22 ... These results suggest that bee venom-induced apoptosis contributes to growth inhibition of U937 cells. Bee venom-induced ... Bee venom is used to hyposensitize individuals highly sensitive to bee stings. There is some evidence that it might also help ...
more infohttps://www.drugs.com/npp/bee-venom.html

skinChemists Bee Venom Treatment Set (Worth £184.79)
					
					| IWOOT
				
			

		

		
		
	skinChemists Bee Venom Treatment Set (Worth £184.79) | IWOOT

Buy skinChemists Bee Venom Treatment Set (Worth £184.79) today at IWOOT. We have great prices on gifts, homeware and gadgets ... Bee Venom Facial Serum:. Combining real bee venom with aquaxyl and hyaluronic acid, the facial serum works to improve nutrient ... Bee Venom Eye Serum:. This rejuvenating eye serum combines real bee venom with hyaluronic acid to counteract dark circles and ... Bee Venom Duo Moisturiser:. This moisturiser combines real bee venom with manuka honey and hyaluronic acid to intensely nourish ...
more infohttps://www.iwantoneofthose.com/skinchemists-bee-venom-treatment-set/11174002.html

Nanoparticles loaded with bee venom kill HIV - ScienceBlog.comNanoparticles loaded with bee venom kill HIV - ScienceBlog.com

Nanoparticles carrying a toxin found in bee venom can destroy human immunodeficiency virus (HIV) while leaving surrounding ... Bee venom contains a potent toxin called melittin that can poke holes in the protective envelope that surrounds HIV, and other ... Nanoparticles carrying a toxin found in bee venom can destroy human immunodeficiency virus (HIV) while leaving surrounding ...
more infohttps://scienceblog.com/60942/60942/
  • The sting's injection of apitoxin into the victim is accompanied by the release of alarm pheromones , a process which is accelerated if the bee is fatally injured. (wikipedia.org)
  • The release of alarm pheromones near a hive may attract other bees to the location, where they will likewise exhibit defensive behaviors until there is no longer a threat, typically because the victim has either fled or been killed. (wikipedia.org)
  • Honey bees will actively seek out and sting when they perceive the hive to be threatened, often being alerted to this by the release of attack pheromones (below). (wikipedia.org)
  • A honey bee that is away from the hive foraging for nectar or pollen will rarely sting, except when stepped on or roughly handled. (wikipedia.org)
  • The queen bee has a barbed but smoother stinger and can, if need be, sting skin-bearing creatures multiple times, but the queen does not leave the hive under normal conditions. (wikipedia.org)
  • According to the American Cancer Society , there is no scientific evidence that apitherapy or bee venom therapy can treat or change the course of cancer or any other disease. (wikipedia.org)
  • Although it is widely believed that a worker honey bee can sting only once, this is a partial misconception: although the stinger is in fact barbed so that it lodges in the victim's skin , tearing loose from the bee's abdomen and leading to its death in minutes, this only happens if the skin of the victim is sufficiently thick, such as a mammal's. (wikipedia.org)
  • Therefore, the body's reaction to a bee sting may differ significantly from one species to another. (wikipedia.org)
  • Based on a serendipitous obsrevation in one patient with Parkinson s disease (PD), resaerchers wish to verify, in a pre-clinical model of the disease, whether bee venom and one of its components, apamine, are able to stop or slow the loss of dopaminergic neurons. (michaeljfox.org)
  • This study would pave the way for a first clinical trial, which would be fairly easy to organize since bee venom injections are considered to be safe and simple. (michaeljfox.org)
  • Researchers verified, in a pre-clinical model of the disease, that bee venom and one of its components, apamine, are able to stop or slow the loss of dopaminergic neurons, the neuronal cell type most severely affected in PD. (michaeljfox.org)
  • These researchers wish to know whether bee venom and/or its constituent, apamine, are able to slow or halt the disease process in Parkinson s. (michaeljfox.org)
  • They showed that regular bee venom injections are indeed able to slow the degeneration of dopaminergic neurons in the PD model used, and that this effect is partially due to apamine. (michaeljfox.org)
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