Venoms obtained from Apis mellifera (honey bee) and related species. They contain various enzymes, polypeptide toxins, and other substances, some of which are allergenic or immunogenic or both. These venoms were formerly used in rheumatism to stimulate the pituitary-adrenal system.
Insect members of the superfamily Apoidea, found almost everywhere, particularly on flowers. About 3500 species occur in North America. They differ from most WASPS in that their young are fed honey and pollen rather than animal food.
Basic polypeptide from the venom of the honey bee (Apis mellifera). It contains 26 amino acids, has cytolytic properties, causes contracture of muscle, releases histamine, and disrupts surface tension, probably due to lysis of cell and mitochondrial membranes.
Venoms from snakes of the subfamily Crotalinae or pit vipers, found mostly in the Americas. They include the rattlesnake, cottonmouth, fer-de-lance, bushmaster, and American copperhead. Their venoms contain nontoxic proteins, cardio-, hemo-, cyto-, and neurotoxins, and many enzymes, especially phospholipases A. Many of the toxins have been characterized.
Poisonous animal secretions forming fluid mixtures of many different enzymes, toxins, and other substances. These substances are produced in specialized glands and secreted through specialized delivery systems (nematocysts, spines, fangs, etc.) for disabling prey or predator.
Venoms produced by the wasp (Vespid) family of stinging insects, including hornets; the venoms contain enzymes, biogenic amines, histamine releasing factors, kinins, toxic polypeptides, etc., and are similar to bee venoms.
Venoms from snakes of the genus Naja (family Elapidae). They contain many specific proteins that have cytotoxic, hemolytic, neurotoxic, and other properties. Like other elapid venoms, they are rich in enzymes. They include cobramines and cobralysins.
Phospholipases that hydrolyze the acyl group attached to the 2-position of PHOSPHOGLYCERIDES.
Venoms from SNAKES of the viperid family. They tend to be less toxic than elapid or hydrophid venoms and act mainly on the vascular system, interfering with coagulation and capillary membrane integrity and are highly cytotoxic. They contain large amounts of several enzymes, other factors, and some toxins.
Phospholipases that hydrolyze one of the acyl groups of phosphoglycerides or glycerophosphatidates.
Venoms from snakes of the family Elapidae, including cobras, kraits, mambas, coral, tiger, and Australian snakes. The venoms contain polypeptide toxins of various kinds, cytolytic, hemolytic, and neurotoxic factors, but fewer enzymes than viper or crotalid venoms. Many of the toxins have been characterized.
Venoms of arthropods of the order Araneida of the ARACHNIDA. The venoms usually contain several protein fractions, including ENZYMES, hemolytic, neurolytic, and other TOXINS, BIOLOGICAL.
A subcategory of secreted phospholipases A2 with specificity for PHOSPHATIDYLETHANOLAMINES and PHOSPHATIDYLCHOLINE. It occurs as a component of VENOMS and as a mammalian secretory phospholipase A2. The creation of this group is based upon similarities in the structural determinants of the enzymes including a long amino-terminal domain, a conserved group III-specific domain, and a long carboxyl-terminal domain.
A highly neurotoxic polypeptide from the venom of the honey bee (Apis mellifera). It consists of 18 amino acids with two disulfide bridges and causes hyperexcitability resulting in convulsions and respiratory paralysis.
Venoms from animals of the phylum Arthropoda. Those most investigated are from scorpions and spiders of the class Arachnidae and from ant, bee, and wasp families of the Insecta order Hymenoptera. The venoms contain protein toxins, enzymes, and other bioactive substances and may be lethal to man.
Venoms from animals of the order Scorpionida of the class Arachnida. They contain neuro- and hemotoxins, enzymes, and various other factors that may release acetylcholine and catecholamines from nerve endings. Of the several protein toxins that have been characterized, most are immunogenic.
Bites and stings inflicted by insects.
Immunosuppression by the administration of increasing doses of antigen. Though the exact mechanism is not clear, the therapy results in an increase in serum levels of allergen-specific IMMUNOGLOBULIN G, suppression of specific IgE, and an increase in suppressor T-cell activity.
Designated locations along nerves or organ meridians for inserting acupuncture needles.
An extensive order of highly specialized insects including bees, wasps, and ants.
A genus of poisonous snakes of the VIPERIDAE family. About 50 species are known and all are found in tropical America and southern South America. Bothrops atrox is the fer-de-lance and B. jararaca is the jararaca. (Goin, Goin, and Zug, Introduction to Herpetology, 3d ed, p336)
Antisera used to counteract poisoning by animal VENOMS, especially SNAKE VENOMS.
Venoms produced by FISHES, including SHARKS and sting rays, usually delivered by spines. They contain various substances, including very labile toxins that affect the HEART specifically and all MUSCLES generally.
Venoms from the superfamily Formicoidea, Ants. They may contain protein factors and toxins, histamine, enzymes, and alkaloids and are often allergenic or immunogenic.
Solutions or mixtures of toxic and nontoxic substances elaborated by snake (Ophidia) salivary glands for the purpose of killing prey or disabling predators and delivered by grooved or hollow fangs. They usually contain enzymes, toxins, and other factors.
A class of enzymes that catalyze the hydrolysis of phosphoglycerides or glycerophosphatidates. EC 3.1.-.
A family of extremely venomous snakes, comprising coral snakes, cobras, mambas, kraits, and sea snakes. They are widely distributed, being found in the southern United States, South America, Africa, southern Asia, Australia, and the Pacific Islands. The elapids include three subfamilies: Elapinae, Hydrophiinae, and Lauticaudinae. Like the viperids, they have venom fangs in the front part of the upper jaw. The mambas of Africa are the most dangerous of all snakes by virtue of their size, speed, and highly toxic venom. (Goin, Goin, and Zug, Introduction to Herpetology, 3d ed, p329-33)
An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progressing URTICARIA, respiratory distress, vascular collapse, systemic SHOCK, and death.
An enzyme that catalyzes the random hydrolysis of 1,4-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate. (From Enzyme Nomenclature, 1992) There has been use as ANTINEOPLASTIC AGENTS to limit NEOPLASM METASTASIS.
Venoms from mollusks, including CONUS and OCTOPUS species. The venoms contain proteins, enzymes, choline derivatives, slow-reacting substances, and several characterized polypeptide toxins that affect the nervous system. Mollusk venoms include cephalotoxin, venerupin, maculotoxin, surugatoxin, conotoxins, and murexine.
A sweet viscous liquid food, produced in the honey sacs of various bees from nectar collected from flowers. The nectar is ripened into honey by inversion of its sucrose sugar into fructose and glucose. It is somewhat acidic and has mild antiseptic properties, being sometimes used in the treatment of burns and lacerations.
The science concerned with the detection, chemical composition, and biological action of toxic substances or poisons and the treatment and prevention of toxic manifestations.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
The bestowing of tangible or intangible benefits, voluntarily and usually without expectation of anything in return. However, gift giving may be motivated by feelings of ALTRUISM or gratitude, by a sense of obligation, or by the hope of receiving something in return.
Limbless REPTILES of the suborder Serpentes.
The anatomical frontal portion of the mandible, also known as the mentum, that contains the line of fusion of the two separate halves of the mandible (symphysis menti). This line of fusion divides inferiorly to enclose a triangular area called the mental protuberance. On each side, inferior to the second premolar tooth, is the mental foramen for the passage of blood vessels and a nerve.
Characteristics or attributes of persons or things which elicit pleasurable feelings.
Devices that cover the nose and mouth to maintain aseptic conditions or to administer inhaled anesthetics or other gases. (UMDNS, 1999)
A serotype of botulinum toxins that has specificity for cleavage of SYNAPTOSOMAL-ASSOCIATED PROTEIN 25.
Lists of persons or organizations, systematically arranged, usually in alphabetic or classed order, giving address, affiliations, etc., for individuals, and giving address, officers, functions, and similar data for organizations. (ALA Glossary of Library and Information Science, 1983)
Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.
A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
Arthropods of the order Scorpiones, of which 1500 to 2000 species have been described. The most common live in tropical or subtropical areas. They are nocturnal and feed principally on insects and other arthropods. They are large arachnids but do not attack man spontaneously. They have a venomous sting. Their medical significance varies considerably and is dependent on their habits and venom potency rather than on their size. At most, the sting is equivalent to that of a hornet but certain species possess a highly toxic venom potentially fatal to humans. (From Dorland, 27th ed; Smith, Insects and Other Arthropods of Medical Importance, 1973, p417; Barnes, Invertebrate Zoology, 5th ed, p503)
Oleagenous substances used topically to soothe, soften or protect skin or mucous membranes. They are used also as vehicles for other dermatologic agents.
Maintenance of the hygienic state of the skin under optimal conditions of cleanliness and comfort. Effective in skin care are proper washing, bathing, cleansing, and the use of soaps, detergents, oils, etc. In various disease states, therapeutic and protective solutions and ointments are useful. The care of the skin is particularly important in various occupations, in exposure to sunlight, in neonates, and in PRESSURE ULCER.

IL-10-induced anergy in peripheral T cell and reactivation by microenvironmental cytokines: two key steps in specific immunotherapy. (1/345)

Specific immunotherapy (SIT) is widely used for treatment of allergic diseases and could potentially be applied in other immunological disorders. Induction of specific unresponsiveness (anergy) in peripheral T cells and recovery by cytokines from the tissue microenvironment represent two key steps in SIT with whole allergen or antigenic T cell peptides (PIT). The anergy is directed against the T cell epitopes of the respective antigen and characterized by suppressed proliferative and cytokine responses. It is initiated by autocrine action of IL-10, which is increasingly produced by the antigen-specific T cells. Later in therapy, B cells and monocytes also produce IL-10. The anergic T cells can be reactivated by different cytokines. Whereas IL-15 and IL-2 generate Th1 cytokine profile and an IgG4 antibody response, IL-4 reactivates a Th2 cytokine pattern and IgE antibodies. Increased IL-10 suppresses IgE and enhances IgG4 synthesis, resulting in a decreased antigen-specific IgE:IgG4 ratio, as observed normally in patients after SIT or PIT. The same state of anergy against the major bee venom allergen, phospholipase A2, can be observed in subjects naturally anergized after multiple bee stings. Together, these data demonstrate the pivotal role of autocrine IL-10 in induction of specific T cell anergy and the important participation of the cytokine microenvironment in SIT. Furthermore, knowledge of the mechanisms explaining reasons for success or failure of SIT may enable possible predictive measures of the treatment.  (+info)

Lipolytic modification of LDL by phospholipase A2 induces particle aggregation in the absence and fusion in the presence of heparin. (2/345)

One of the first events in atherogenesis is modification of low density lipoprotein (LDL) particles in the arterial wall with ensuing formation of aggregated and fused lipid droplets. The accumulating particles are relatively depleted in phosphatidylcholine (PC). Recently, secretory phospholipase A2 (PLA2), an enzyme capable of hydrolyzing LDL PC into fatty acid and lysoPC molecules, has been found in atherosclerotic arteries. There is also evidence that both LDL and PLA2 bind to the glycosaminoglycan (GAG) chains of extracellular proteoglycans in the arterial wall. Here we studied the effect of heparin GAG on the lipolytic modification of LDL by PLA2. Untreated LDL, heparin-treated LDL, and heparin-bound LDL were lipolyzed with bee venom PLA2. In the presence of albumin, lipolysis resulted in aggregation in all 3 preparations of the LDL particles. Lipolysis of untreated LDL did not result in aggregation if albumin was absent from the reaction medium, and the lipolytic products accumulated in the particles rendering them negatively charged. However, heparin-treated and heparin-bound lipolyzed LDL particles aggregated even in the absence of albumin. Importantly, in the presence of albumin, some of the heparin-treated and heparin-bound lipolyzed LDL particles fused, the proportion of fused particles being substantially greater when LDL was bound to heparin during lipolysis. In summary, lipolysis of LDL PC by PLA2 under physiological conditions, which allow transfer of the lipolytic degradation products to albumin, leads to fusion of LDL particles in the presence, but not in the absence, of heparin. Thus, it is possible that within the GAG meshwork of the arterial intima, PLA2-induced modification of LDL is one source of the lipid droplets during atherogenesis.  (+info)

Update on the status of Africanized honey bees in the western states. (3/345)

The Africanized honey bee (AHB), Apis mellifera scutella--perhaps better known as the "killer bee"--has arrived in the western United States and in southern California, following a nearly 50-year north-ward migration across South and Central America. First detected near Hidalgo, Texas in October 1993, the bees continue to advance 100 to 300 miles per year by colonizing existing hives or forming new hives in the wild. Although the AHB's "killer" reputation has been greatly exaggerated, the presence of AHBs will increase the chances of people being stung.  (+info)

Mass envenomations by honey bees and wasps. (4/345)

Stinging events involving honey bees and wasps are rare; most deaths or clinically important incidents involve very few stings (< 10) and anaphylactic shock. However, mass stinging events can prove life-threatening via the toxic action of the venom when injected in large amounts. With the advent of the Africanized honey bee in the southwestern United States and its potential for further spread, mass envenomation incidents will increase. Here we review the literature on mass stinging events involving honey bees and wasps (i.e., yellowjackets, wasps, and hornets). Despite different venom composition in the two insect groups, both may cause systemic damage and involve hemolysis, rhabdomyolysis, and acute renal failure. Victim death may occur due to renal failure or cardiac complications. With supportive care, however, most victims should be able to survive attacks from hundreds of wasps or approximately 1000 honey bees.  (+info)

Ultraviolet Raman examination of the environmental dependence of bombolitin I and bombolitin III secondary structure. (5/345)

Bombolitin I and III (BI and BIII) are small amphiphilic peptides isolated from bumblebee venom. Although they exist in predominately nonhelical conformations in dilute aqueous solutions, we demonstrate, using UV Raman spectroscopy, that they become predominately alpha-helical in solution at pH > 10, in high ionic strength solutions, and in the presence of trifluoroethanol (TFE) and dodecylphosphocholine (DPC) micelles. In this paper, we examine the effects of electrostatic and hydrophobic interactions that control folding of BI and BIII by systematically monitoring their secondary structures as a function of solution conditions. We determine the BI and BIII secondary structure contents by using the quantitative UV Raman methodology of Chi et al. (1998. Biochemistry. 37:2854-2864). Our findings suggest that the alpha-helix turn in BIII at neutral pH is stabilized by a salt bridge between residues Asp2 and Lys5. This initial alpha-helical turn results in different BI and BIII alpha-helical folding mechanisms observed in high pH and high salt concentrations: BIII folds from its single alpha-helix turn close to its N-terminal, whereas the BI alpha-helix probably nucleates within the C-terminal half. We also used quasielastic light scattering to demonstrate that the BI and BIII alpha-helix formation in 0.2 M Ca(ClO4)2 is accompanied by formation of trimers and hexamers, respectively.  (+info)

On the diversity and heterogeneity of H-2(d)-restricted determinants and T cell epitopes from the major bee venom allergen. (6/345)

One of the main limitations of using synthetic peptides for immunotherapy in allergic patients is the difficulty to delineate the immunodominant T cell epitopes which are necessarily dependent on HLA molecules. We have thus addressed the question of the role of MHC II molecules in immunodominant epitopes selection in the particular case of the major bee venom allergen (API m1). To exhaustively and easily explore it, we used BALB/c mice whose H-2 haplotype is associated with high IgE and IgG responses to API m1. By means of extensive sets of synthetic peptides, we investigated the specificity of polyclonal T cells and monoclonal hybridomas from mice immunized with API m1 and delineated four immunodominant regions, restricted to either the I-E(d) or the I-A(d) molecule. All the peptides were also tested for their capacity to bind to immunopurified MHC II molecules. Eight determinants of high affinity were identified. They clustered into three distinct regions and were largely overlapping. They included all the immunodominant epitopes, but half of them were not capable of stimulating T cells. Strikingly, interacting surfaces with either the TCR or MHC II molecule greatly differed from one determinant to another. In one case, we observed that flanking regions exerted a particular action on T cell stimulation which prevented the fine epitope localization. Our results underline the diversity and complexity of MHC II-restricted determinants and T cell epitopes from the major bee venom allergen, even in a single haplotype. These data also participate in the development of alternative approaches to conventional immunotherapy.  (+info)

Secreted phospholipases A(2), a new class of HIV inhibitors that block virus entry into host cells. (7/345)

Mammalian and venom secreted phospholipases A(2) (sPLA(2)s) have been associated with a variety of biological effects. Here we show that several sPLA(2)s protect human primary blood leukocytes from the replication of various macrophage and T cell-tropic HIV-1 strains. Inhibition by sPLA(2)s results neither from a virucidal effect nor from a cytotoxic effect on host cells, but it involves a more specific mechanism. sPLA(2)s have no effect on virus binding to cells nor on syncytia formation, but they prevent the intracellular release of the viral capsid protein, suggesting that sPLA(2)s block viral entry into cells before virion uncoating and independently of the coreceptor usage. Various inhibitors and catalytic products of sPLA(2) have no effect on HIV-1 infection, suggesting that sPLA(2) catalytic activity is not involved in the antiviral effect. Instead, the antiviral activity appears to involve a specific interaction of sPLA(2)s to host cells. Indeed, of 11 sPLA(2)s from venom and mammalian tissues assayed, 4 venom sPLA(2)s were found to be very potent HIV-1 inhibitors (ID(50) < 1 nM) and also to bind specifically to host cells with high affinities (K(0.5) < 1 nM). Although mammalian pancreatic group IB and inflammatory-type group IIA sPLA(2)s were inactive against HIV-1 replication, our results could be of physiological interest, as novel sPLA(2)s are being characterized in humans.  (+info)

A novel Fab-based antivenom for the treatment of mass bee attacks. (8/345)

The frequency of mass bee attacks has dramatically increased in the Americas following the introduction and spread of the aggressive Africanized 'killer' bee (Apis mellifera scutellata). As yet no specific therapy is available, which led us to develop an ovine Fab-based antivenom as a potential new treatment. Sera from sheep immunized against the venom contained high levels of specific antibodies, as demonstrated by ELISA and by small-scale affinity chromatography, against both whole (A. m. mellifera) venom and purified melittin. A nerve muscle preparation was used to show the myotoxic effects of the venom and neutralization by the antivenom. Antivenom neutralizing ability was also demonstrated using assays for venom phospholipase A2 and in vivo activities. Venom from both European and Africanized bees appeared identical when analyzed by acid-urea gel electrophoresis. This antivenom may therefore provide the first specific therapy for the treatment of mass envenomation by either European or Africanized 'killer' bees.  (+info)

TY - JOUR. T1 - Effective mast cell degranulating peptide inhibitors of the IgE/FcεRI receptor interaction. AU - Buku, Angeliki. AU - Keselman, Inna. AU - Lupyan, Dmitry. AU - Mezei, Mihaly. AU - Price, Joseph. PY - 2008/8/1. Y1 - 2008/8/1. N2 - Previous studies with mast cell degranulating (MCD) peptide have shown that peptide [Ala12]MCD 8 was an inhibitor of IgE binding to mast cell receptors. In an attempt to produce increased inhibition, analogs were synthesized that maintained the alanine residue in position 12 in the MCD peptide sequence and were further modified at both termini. Analogs modified at the C-terminus were [Ala12,desLys21]MCD 2 and [Ala 12,d-Lys21]MCD 4. N-terminus modifications were [desLys6-Arg7-His8,Ala12]MCD 1, [Ala6, Ala12]MCD 6, and [Val6,Ala 12]MCD 7. To assess the role of the Proline12, analogs [d-Ala12]MCD 3 and [Meleu12]MCD 5 were also synthesized. The analogs were tested for binding to the IgE receptor in cultured mast cells. Inhibitory activity of IgE-caused ...
From: [email protected] (Andy Nachbaur) Subject: bvemon faq Date: Thu, 10 Apr 1997 14:03:00 GMT Organization: WILD BEES BBS (209) 826-8107 LOS BANOS, CA To: [email protected] From: [email protected] (Darlene Scribilo) Subject: Bee Venom Therapy -FAQ Date: February 04, 1996 11:24 Hi Folks, I have found a very interesting article in the American Bee Journal, Vol. 136, No. 2, 1996, pp. 107-109, which I thought would interest you. It is on bee venom therapy and I have the permission of the author to post it here. Bee Venom - Frequently Asked Questions Bee venom therapy is becoming recognized and accepted for treating certain human ailments. Honey bee venom can be used in many different ways and forms. I receive dozens of letters from people who ask me to send all the information I have on bee venom. I answer all the letters, however, I am unable to send them all of my approximately 5,000 pages of literature. In order to help I have gathered the most frequently asked questions which I will ...
Abstract: Alcohol consumption increases apoptosis of hepatocytes. Death of hepatocytes is a characteristic feature of chronic liver disease for various causes. Bee venom (Apis mellifera) has been traditionally used for the treatment of various chronic diseases, such as chronic inflammatory arthritis and chronic liver disease. However, the precise mechanism for bee venom in chronic liver disease is not still cleared. To assess the effects of bee venom in chronic liver disease, we investigated the potential role of the bee venom in the ethanol-induced hepatocyte apoptosis. Bee venom treatment inhibited the apoptotic cell morphology and increased the cell viability in ethanol-induced hepatocyte apoptosis. With ethanol treatment, bee venom-treated hepatocytes increased activity of Bcl-2 and Bcl-xL, reduced activity of Bax, Caspase and PARP. In conclusion, bee venom treatment in ethanol-induced hepatocyte apoptosis occurred through the regulation of Bcl family with subsequent inactivation of the ...
TY - JOUR. T1 - Increased expression of osteopontin is associated with long-term bee venom immunotherapy. AU - Konno, Satoshi. AU - Golden, David B.K.. AU - Schroeder, John. AU - Hamilton, Robert G.. AU - Lichtenstein, Lawrence M.. AU - Huang, Shau Ku. PY - 2005/1/1. Y1 - 2005/1/1. N2 - Background: Venom allergen immunotherapy (VIT) is proven to be highly effective for insect allergy, but the mechanisms and the biomarkers associated with clinical efficacy remain elusive. Objective: The aim of this study was to identify candidate biomarkers associated with successful VIT. Methods: Gene chip array and clustering analyses of PBMCs from subjects with or without VIT were performed. Results: From gene chip array and clustering analyses, an increased expression of osteopontin was found in patients who completed 5 to 6 years of VIT and discontinued therapy for 3 to 6 years (completed treatment group) compared with the untreated group. A significantly higher level of serum osteopontin was found in the ...
Price for cream, ointment, balm, bee venom varies depending on the type of drug and its packaging. So, the cost of the ointment limits Apizartron in tube 20 g varies from 206 to 216 rubles per package; 911 Gel-balm with bee venom in tuba 100 ml costs from 94 to 156 rubles; Cream Sofya with bee venom in tuba 125 g - from 168 to 200 rubles. You can buy drugs based on bee venom in most pharmacies in Moscow and other Russian cities. ...
Stings from bees or wasps produce a variety of clinical manifestations [1-7]. In cases of corneal bee sting discussed in the literature, corneal complications have been reported most frequently [2-4]. In all these cases, the corneal edema regressed and infiltrates resulted in a corneal scar 4 to 6 weeks after removal of the stinger and the initiation of treatment. Corneal edema has been explained by cell death caused by activation of the complement cascade by proteins in the bee venom, leading to the production of anaphylotoxins and chemotactic factors [1, 3]. Bee venom is a complex toxin having various impacts and components. It contains two types of biogenic amines: non-enzymatic polypeptide toxins (melittin, apamin, mast cell degranulating peptide) and enzymes (phospholipase A, phospholipase B, hyaluronidase). Ocular inflammation increases capillary protein permeability allowing greater leakage of proteins into the vitreous space.. The difference of wasp sting effects depends on the type of ...
Dr. Weeks Comment: The idea that honeybee venom offers anti-cancer properties seems implausible until one penetrates the very biochemistry of this remarkable and highly refined biologically active substance. I have worked intensively with apitherapy since co-founding the American Apitherapy Society with master Bee-keeper Charlie Mraz in the early 1980s. So enjoy the brilliant science that follows. …Melittin is a major polypeptide in honey bee venom that has been used traditionally against chronic inflammation and cancer… …Apis mellifera venom consists of many biologically active molecules and has been reported to exhibit remarkable anti-cancer effects, often promoting an apoptosis-like death phenotype… Environ Toxicol Pharmacol. 2013 Jun 28;36(2):697-705. doi: 10.1016/j.etap.2013.06.009. [Epub ahead of print]. Melittin: A lytic peptide with anticancer properties.. Gajski G, Garaj-Vrhovac V.. Source. Institute for Medical Research and Occupational Health, Mutagenesis Unit, 10000 ...
Some people swear by the therapeutic effects of bee venom therapy. This can consist of actual bee stings, bee venom applied in a cream,or bee venom taken in the form of tablets. Those with Lyme disease, M.S. symptoms, Chronic Fatigue Syndrome, Fibromyalgia...etc often report good results. Of course no one therapy works for everyone and people must decide what works best for them. For more information you can go to the following link ...
Bee venom and phospholipase A2 extracted from bee venom enhanced guanylate cyclase (E.C. 4.6.1.2) activity two- to threefold in rat liver, lung, heart, kidney, ileum, and cerebellum. Dose-response relationships revealed that bee venom at concentrations as low as 1 microgram per milliliter and phospholipase A2 at 1 microunit per milliliter caused a maximal enhancement of guanylate cyclase.. ...
Systemic Immediate Hypersensitive Reactions after Treatment with Sweet Bee Venom: A Case Report - anaphylaxis;bee venom;hypersensitivity reaction;sweet bee venom;systemic immediate;
Bee Venom could be used as a treatment for chronic back pain. In a clinical trial, patients suffering from chronic lower back pain were given injections of bee venom.In the trial in South Korea, a group of patients were split up and half were given bee venom and the other half had ibuprofen for their…
Discover an anti-ageing skincare featuring a unique blend of Bee Venom, stem cells & award-winning peptide technology. Free delivery on all orders.Bee Venom
Researchers verified, in a pre-clinical model of the disease, that bee venom and one of its components, apamine, are able to stop or slow the loss of dopaminergic neurons, the neuronal cell type most severely affected in PD. They showed that regular bee venom injections are indeed able to slow the degeneration of dopaminergic neurons in the PD model used, and that this effect is partially due to apamine. However, the complete list of compounds responsible for this effect and the mechanism(s) of action remain to be characterized.. ...
TY - JOUR. T1 - Effect of bee venom and its fractions on the release of pro-inflammatory cytokines in PMA-differentiated U937 cells co-stimulated with LPS. AU - Tusiimire, Jonans. AU - Wallace, Jennifer. AU - Woods, Nicola. AU - Dufton, Mark J.. AU - Parkinson, John A.. AU - Abbott, Grainne. AU - Clements, Carol J.. AU - Young, Louise. AU - Park, Jin Kyu. AU - Jeon, Jong Woon. AU - Ferro, Valerie A.. AU - Watson, David G.. PY - 2016/4/19. Y1 - 2016/4/19. N2 - The venom of Apis mellifera (honey bee) has been reported to play a role in immunotherapy, but existing evidence to support its immuno-modulatory claims is insufficient. Four fractions from whole bee venom (BV) were separated using medium pressure liquid chromatography. Their ability to induce the production of cytokines TNFα, IL-1β and IL-6 in phorbol-12-myristate-13-acetate (PMA)-treated U937 cells was assessed. The levels of the three cytokines produced by stimulation with the four fractions and crude BV without LPS were not ...
The effects of mast cell degranulating peptide (MCDP), a toxin from the honey bee, and of dendrotoxin (DTX), a toxin from the green mamba snake, were studied in voltage-clamped experiments with myelinated nerve fibres of Xenopus. MCDP and DTX blocked part of the K+ current. About 20% of the K+ current, however, was resistant to the toxins even in high concentrations. In Ringer solution half-maximal block was reached with concentrations of 33 nM MCDP and 11 nM DTX. In high-K+ solution the potency of both toxins was lower. β-Bungarotoxin (β-BuTX), another snake toxin, also blocked part of the K+ current, but was less potent than MCDP and DTX. Tail currents in high-K+ solution were analysed and three K+ current components were separated according to Dubois (1981b). Both MCDP and DTX selectively blocked a fast deactivating, slowly inactivating K+ current component which steeply activates between E = -60 mV and E = -40 mV (component f1). In concentrations around 100 nM, MCDP and DTX blocked neither ...
Theres been a lot of talk about how bee venom is used in skincare to plump up and firm the skin. This is the low down - bee venom acts as an irritation as if it has been stung with the peptide Melittin. It causes an increased blood circulation to the deep layers of the skin and stimulates cell regeneration and the production of elastin and collagen to lift, plump and tighten the skin. This means that it can be used as a natural alternative to clinical treatments that involve painful needles ...
NatureBee Bee Venom Mask works by fooling the skin into thinking it has been gently stung. This then stimulates the body into producing naturally occurring chemicals collagen and elastin. The process is completely pain free and you may feel a slight tingling sensation. Immediately after application your skin will look and feel tighter. The effects of NatureBee Bee Venom Mask are cumulative. You will notice after longer use a more dramatic effect. For best results apply mask freshly cleansed neck and face and leave on overnight. The mask also works well applied as a cream first thing in the morning underneath make up.. *No bees were harmed in the making of this product. To extract the venom, a pane of glass is placed alongside the hive and a gentle electrical current is run through it, which harmlessly encourages the insects to sting the surface.. Slow down skin aging ...
Fifteen male Wistar rats were randomly divided into bee venom treatment group (BV group), CIA model group, and control group. In the former two groups, CIA was induced by injections of collagen II+IFA (0.2 mL) via the tail vein, and in the control group, normal saline was injected instead. The rats in BV group received daily injection of 0.1 mL (3 mg/mL) bee venom for 7 consecutive days. All the rats were assessed for paw thickness and arthritis index from days 14 to 21, and the pain threshold was determined on day 21. The expressions of TRPV1 and TrkA in the dorsal root ganglion at the level of L4-6 were detected using immunohistochemistry and Western blotting, respectively ...
Pure New Zealand Bee Venom stimulates the production of collagen and elastin creating a tightening and smoothing effect, while Manuka Honey and Vitamins C and E improve skin texture and protect from everyday environmental pollution. Suitable for all skin types. How does it work? The Bee Venom is used to fool the skin
Alpha Lipid Bee Venom adalah satu produk penjagaan kulit menggunakan bee venom dari New Zealand. Cuba satu sekarang dan rasai perbezaannya.
The researchers theorized that bee venom could be used to synthetically modify erroneous dopamine levels for people suffering from Parksinsons. Dopamine comprises 1.5 percent of apitoxin and is a neurotransmitter found in the human brain. Researchers hoped that treatment with bee venom could eliminate the adverse side effects of conventional anti-Parkinsonian medication, such as L-DOPA, which often include hypotension, arrhythmias, nausea, gastrointestinal bleeding, and disturbed respiration ...
Bee Venom & Placenta 24 Carat Gold Ultimate Crème is the ultimate rejuvenation treatment with bee venom, placenta & liquid gold. Shop now for free UK delivery.
Different bee venoms are on the market. I use the product VeneX, which comes in two different strengths: VeneX-10 and VeneX-20 (Table 1.). VeneX-20 is twice as concentrated as VeneX-10. VeneX-10 contains 1.0 mg of bee venom per 1.0 ml. A 0.1 ml of this solution delivers approximately the same amount of bee venom as a natural bee sting. The content of melittin in bee venom is dependent on where it is collected on the hive; the season and the pollen source the bees have access to at the time. Generally between one third and one half of the venom is melittin. Because of these variables the symptoms seen on administration of the venom can also vary. Bee venom is used for desensitization and is approved with the FDA for this purpose. There is an official monograph in the Homeopathic Pharmacopoea of the United States (HPUS), also recognized by the FDA ...
In the present study, to our knowledge, we first demonstrated that bvPLA2 is the major BV compound capable of inducing Treg expansion without altering the total composition of the other cell types in vivo and in vitro. Our previous report showed that BV has therapeutic effects on the MPTP-induced mouse model of PD via modulating the neuroinflammatory response and increasing the proportion of functional Tregs (23). In this study, we showed that bvPLA2 has neuroprotective effects by suppressing microglial activation and reducing the infiltrating CD4+ T cells in the MPTP-induced mouse model of PD. In addition to the neuroprotective effects, bvPLA2 directly binds to the mannose receptor (CD206) on DCs, and this binding induces the release of PGE2, which promotes Treg induction in CD4 T cells.. Microglia are resident innate immune cells of the CNS found in and around degenerating neurons (10-12) that are rapidly activated in response to neuronal damage and significantly contribute to secondary ...
Immunity. 2013 Nov 14;39(5):976-85. doi: 10.1016/j.immuni.2013.10.006. Epub 2013 Oct 24. Research Support, N.I.H., Extramural; Research Support, Non-U.S. Govt
Bee venom is a natural compound produced by the honey bee (Apis mellifera), and has been reported as having the biological and pharmacological activities, including anti-bacterial, anti-viral and anti-inflammation. In the present study, the inhibitory effects of bee venom and its major peptide components on the tumor invasion were demonstrated. It was confirmed the inhibitory effects of bee venom, melittin, and apamin on the EGF-induced invasion of breast cancer cells. Transwell invasion and wound-healing assays showed that bee venom and melittin significantly inhibits the EGF-induced invasion and migration of breast cancer cells. Also, bee venom and melittin reduced the EGF-stimulated F-actin reorganization at the leading edge, but apamin did not affect. Particularly, melittin inhibited the EGF-induced MMP-9 expression via blocking the NF-κB and PI3K/Akt/mTOR pathway. In addition, melittin significantly suppressed the EGF-induced FAK phosphorylation through inhibition of mTOR/p70S6K/4E-BP1 ...
Bee venom is a colorless liquid made up of proteins, enzymes, and soluble amino acids. It is one of the traditional folk remedies used....
Apamin is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom). Dry bee venom consists of 2-3% of apamin. Apamin selectively blocks SK channels, a type of Ca2+-activated K+ channel expressed in the central nervous system. Toxicity is caused by only a few amino acids, these are cysteine1, lysine4, arginine13, arginine14 and histidine18. These amino acids are involved in the binding of apamin to the Ca2+-activated K+ channel. Due to its specificity for SK channels, apamin is used as a drug in biomedical research to study the electrical properties of SK channels and their role in the afterhyperpolarizations occurring immediately following an action potential. The first symptoms of apitoxin (bee venom), that are now thought to be caused by apamin, were described back in 1936 by Hahn and Leditschke. Apamin was first isolated by Habermann in 1965 from Apis mellifera, the Western honey bee. Apamin was named after this bee. Bee venom contains many other compounds, like histamine, ...
Nanoparticles carrying a toxin found in bee venom can destroy human immunodeficiency virus (HIV) while leaving surrounding cells unharmed, research
Bee venom and its main constituent melittin (MEL) have been extensively studied in the treatment of tumors. However, the non-specific cytotoxicity
Over the last few years bee researchers have found that bee venom has some of the most powerful anti - aging properties known to man. When correctly combined and used regularly, one can achieve youthful looking skin and a more plump look - voiding the need for expensive and often invasive surgeries.
Bee venom can have a positive impact on your skin -- and a new line of skin care products is bringing those benefits to you without all the nasty stings.
Amyotrophic lateral sclerosis (ALS) is caused by the degeneration of lower and upper motor neurons, leading to muscle paralysis and respiratory failure. However, there is no effective drug or therapy to treat ALS. Complementary and alternative medicine (CAM), including acupuncture, pharmacopuncture, herbal medicine, and massage is popular due to the significant limitations of conventional therapy. Bee venom acupuncture (BVA), also known as one of pharmacopunctures, has been used in Oriental medicine to treat inflammatory diseases. The purpose of this study is to investigate the effect of BVA on the central nervous system (CNS) and muscle in symptomatic hSOD1G93A transgenic mice, an animal model of ALS. Our findings show that BVA at ST36 enhanced motor function and decreased motor neuron death in the spinal cord compared to that observed in hSOD1G93A transgenic mice injected intraperitoneally (i.p.) with BV. Furthermore, BV treatment at ST36 eliminated signaling downstream of inflammatory proteins
Bee Venom (BV) has long been used in Korea to relieve pain symptoms and to treat inflammatory diseases, such as rheumatoid arthritis. The underlying mechanisms of the anti-inflammatory and analgesic actions of BV have been proved to some extent. Additionally, recent clinical and experimental studies have demonstrated that BV and BV-derived active components are applicable to a wide range of immunological and neurodegenerative diseases, including autoimmune diseases and Parkinsons disease. These effects of BV are known to be mediated by modulating immune cells in the periphery, and glial cells and neurons in the central nervous system. This review will introduce the scientific evidence of the therapeutic effects of BV and its components on several immunological and neurological diseases, and describe their detailed mechanisms involved in regulating various immune responses and pathological changes in glia and neurons.
Therapeutic Effects of Bee Venom on Immunological and Neurological Diseases 새창 Abstract Bee Venom (BV) has long been used in Korea to relieve pain symptoms and to treat inflammatory diseases, such as rheumatoid arthritis. The underlying mechanisms of the anti-inflammatory and analgesic actions of BV have been proved to some extent. Additionally, recent clinical and experiment…. 최고관리자 쪽지보내기 메일보내기 자기소개 전체게시물 ...
Although it has been previously reported that bee venom can inhibit human cancer cell growth through induction of apoptosis in many cancer cell lines such as prostate cancer, breast cancer and melanoma, there is no finding of the induction of apoptosis in human T cell acute lymphoblastic leukemia cells by BV [6-8]. Based on our knowledge, the present study is the first report about examination of the synergistic effect of BV with a palladium metal-based component.. Analysis of cytotoxicity by MTT assay proved that BV is both time- and dose-dependent in its cytotoxic effects, given that the Cc50 values of this component were 6.3 and 0.6 μg/mL after 24 and 48 hours, respectively. Due to the inconsistency in the MTT assay data - as a result of precipitation of the BV at high concentrations after 24 and 48 hours, and at low concentrations after 48 hours - only the concentrations less than 10 μg/mL were applied in these experiments. At these concentrations the findings were acceptable, except at 8 ...
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Apitherapy іѕ οftеn аƖѕο called bee therapy аnԁ іѕ tһе basically tһе uѕе οf bee products tο treat different conditions. Tһеrе аrе a number οf products tһаt саn һаνе health benefits аnԁ bе used іn apitherapy аnԁ tһеу include pollen, raw honey аnԁ royal jelly һοwеνеr tһе main one used іѕ bee venom. Tһе uѕе οf bee products аnԁ іn particular bee venom dates back tο ancient Greece, Egypt аnԁ China. In fact іt іѕ believed tһаt Hippocrates wһο іѕ considered tο bе tһе father οf medicine actually used bee stings tο treat people fοr conditions such аѕ arthritis. In addition іn 1888 Philip Terc published a paper οn bee venom аnԁ rheumatism. Today bee stings аrе used throughout tһе world аѕ a treatment fοr a wide variety οf different conditions аnԁ below wе wіƖƖ consider tһе benefits tһаt уοu сοuƖԁ ɡеt frοm tһе treatment ...
Insect venoms are complicated. Really complicated. You could be forgiven for thinking that it must be a relatively simple company of chemicals that makes up the painful sensation of a bee or wasp sting, but in fact a hugely complex mixture of all sorts of compounds - proteins, peptides, enzymes, and other smaller molecules - go into a small amount of venom. The range of compounds is far too vast to detail every single one - but we can examine some of the major constituents in bee, wasp, hornet and ant venom.. Well start with the venom about which we know the most - that of bees. Unlike many other insect venoms, we have a relatively good idea of the percentage breakdown of the venom of your average bee. When the bee stings, the venom is mixed with water, so the actual composition of the substance it injects into you is around 88% water and 12% venom. From this point onward, well consider the percentages of compounds purely in the venom itself.. The main toxic component of bee venom, also ...
VIT is globally accepted as the treatment of choice in venom allergy.15. Although 44 patients in the current study declared a negative effect of VIT on work, caused by changing working time and economic loss due to VIT, most of our participants declared an indifferent effect of VIT on work. Individuals at high risk of sting reported a positive VIT impact on work. This will support the accepted medical approach that occupation may influence the decision to initiate VIT, also for non-life-threatening reactions.5. Another predictor of a perceived positive effect from VIT was completion of treatment. Participants who have already completed VIT are probably more aware of the long-term beneficial effects of treatment. They are less likely to report any drawbacks of VIT, such as the time spent in therapy, which can affect work and social life. A relevant number of participants reported a negative impact of VIT on work and even if we could not find any peculiar characteristic of this group, this finding ...
Bee venom phospholipase A2 and the fluorescent probe merocyanine 540 were used to examine plasma membrane phospholipid organization in the spicules released by deoxygenation and reoxygenation of sickle red cells, as well as in reversibly and irreversibly sickled erythrocytes. Digestion of phosphatidyl ethanolamine in spicules was comparable to that of phosphatidyl choline, and these structures were stained by the fluorescent probe. Both assays suggest that membrane lipid asymmetry is disrupted in spicules. The residual cells, from which the spicules were derived, retain the normal asymmetry in phospholipid distribution between the outer and inner leaflets of the plasma membrane bilayer. Comparable experiments with cell fractions enriched in irreversibly sickled cells revealed a partial enhancement of phosphatidyl ethanolamine digestion, confirming the similar experiments of Lubin et al (1981). Staining of these cells with merocyanine 540, however, did not reveal a subfraction of stainable cells, ...
Tertiapin is a 21-amino acid peptide isolated from venom of the European honey bee (Apis mellifera). It blocks two different types of potassium channels, inward rectifier potassium channels (Kir) and calcium activated large conductance potassium channels (BK). Tertiapin is a peptidic component of the venom of the European honey bee (Apis mellifera). Tertiapin peptide is composed of 21 amino acids with the sequence: Ala-Leu-Cys-Asn-Cys-Asn-Arg-Ile-Ile-Ile-Pro-His-Met-Cys-Trp-Lys-Lys-Cys-Gly-Lys-Lys. The methionine residue is sensitive to oxidation, reducing the ability to block the ionic channels. Methionine can be substituted by glutamine in order to prevent the oxidation. The new synthesized peptide is named Tertiapin-Q and does not show any functional change as compared to the original peptide, which makes it a more suitable research tool. Tertiapin has been described as a potent potassium channel blocker, acting on two different types of K+ channels. Tertiapin binds specifically to different ...
Bee Legs and Stingers - Bee stings contain venom which destroys cells in an enemy’s body. Learn about bee stings and find out how the bee stinger is used for defense.
ARLINGTON HEIGHTS, ILL. - If you think summer insects are done setting their sights on ruining your outdoor gathering, think again. Augusts hot and dry climate is the perfect breeding ground for insects, especially yellow jackets. And for the millions of Americans allergic to insect stings, these late summer bugs can be deadly.. According to a report released today in the August issue of Annals of Allergy, Asthma & Immunology, the scientific journal of the American College of Allergy, Asthma and Immunology (ACAAI), insect sting allergy is increasing, affecting five percent of the population. But what much of the population may not understand is that there is something that can be done about it.. While it does not always cure insect sting allergy, venom immunotherapy, a form of allergy shots, can almost always prevent severe reactions to stings, said David Golden, MD, article author and ACAAI fellow. It usually provides long-lasting immunity even after the treatment is stopped.. Even 10 to ...
Try to get the animal away from the bees WITHOUT ENDANGERING YOURSELF. Call your dog inside your house or car. Do not attempt to approach a person or an animal being stung without protective gear (such as a bee keepers suit). If you approach an animal that is being stung, remember that an injured animal may bite or attack unexpectedly. If the animal runs to you with aggravated bees following it, you are likely to be stung.. If possible, douse the animal with soapy water. It is important to use soap and not just water. A mild solution of liquid dish detergent in water (approximately 1/2 cup soap per gallon of water) will immobilize honey bees and kill them within 60 seconds.. Covering the animal with a heavy blanket during a serious stinging incident may also discourage the bees.. Once the animal is away from bees look for stingers. When a honey bee stings, it loses its venom sac and stinger. This means the honey bee dies after it stings, but the stinger may continue to inject venom for up to a ...
Vice-president of the newly re-structured board and president of the association Gagan Deep Singh said that in India the focus is on production of honey alone and other products like bee venom and royal jelly are being ignored. Citing examples of other countries, he said that they are earning huge profits from these two products. Gagan pointed out that bee venom was being used for manufacturing medicines for joint pains and royal jelly was being used for vitality increasing medicines. He said that the newly re-structured National Bee Board would now start exploring both these products as a part of bee keeping ...
I have been trying bee venom ointment(Venex) for a week now and am very excited at the improvement. It may be that the ointment will have to be used continually but maybe there will be an accumulative effect. I also just ordered a type of manuka honey called Actiflex. This also has bee venom in it but you take it orally. It is supposed to also help with the pain issues. From what I understand....you can find out more at the links below.....there is a substance in venom called mellitin. The Rocky Mountain Lab studied this substance a bit and found that it immobilized lyme disease spirochetes. It also helps stimulate the bodys immune system and is supposed to have 10 to 100 times the anti-inflammatory capability...over ...
Vascular dementia (VaD) is caused by the reduction of blood supply by vessel occlusion and is characterized by progressive cognitive decline. VaD incidence has been growing due to the aging population
So, courtesy of my first-ever bee sting and notes from my first aid and emergency care class in chiropractic school from the mid-90s, some thoughts to keep in mind in case you or a loved one is stung by a bee:. If youre stung by a honey bee, try to find the stinger. Honey bees dont always leave their stingers behind, but they often do. The sooner you get a stinger out, the less youll suffer. If youre able to locate the stinger, take the edge of a firm surface, like a credit card or even a finger nail and try to brush or scrape the stinger off. Stingers shouldnt be removed with forceps or with a pinch of your fingers because compressing the attached sac of venom is likely to worsen the injury. If you can see the end of the stinger but cant access it, try using a fingernail to press down into your skin about half an inch away - sometimes, this will allow the tissues surrounding the stinger to relax a bit and allow the stinger to rise enough to scrape it away (this is a commonly used ...
So, courtesy of my first-ever bee sting and notes from my first aid and emergency care class in chiropractic school from the mid-90s, some thoughts to keep in mind in case you or a loved one is stung by a bee:. If youre stung by a honey bee, try to find the stinger. Honey bees dont always leave their stingers behind, but they often do. The sooner you get a stinger out, the less youll suffer. If youre able to locate the stinger, take the edge of a firm surface, like a credit card or even a finger nail and try to brush or scrape the stinger off. Stingers shouldnt be removed with forceps or with a pinch of your fingers because compressing the attached sac of venom is likely to worsen the injury. If you can see the end of the stinger but cant access it, try using a fingernail to press down into your skin about half an inch away - sometimes, this will allow the tissues surrounding the stinger to relax a bit and allow the stinger to rise enough to scrape it away (this is a commonly used ...
There are also a couple of variations on wasps: hornets, which are larger and have black and white rings instead of black and yellow; and yellow jackets, which closely resemble wasps but nest underground instead of above ground. Like wasps, hornets and yellow jackets can sting multiple times. Their venom (and honeybee venom) can be deadly for those with allergies (and not exactly pleasant for those without).. Also, lets not forget about the other type of bee-the bumblebee. They may have the cutest name, but youll know one when you see one by the fact that its absolutely huge, very loud in flight, and capable of inducing panic attacks in otherwise rational adults. They have black and yellow stripes and pollinate like honeybees-but like wasps and their cousins, bumblebees can sting you as many times as they like. ...
Allergic reactions to insect stings constitute a major medical problem, resulting in about 50 recognized fatalities annually in the United States and are likely responsible for other unexplained sudden deaths. People at risk often are very anxious about future stings and modify their daily living patterns and lifestyles. Recent advances have provided very effective treatment. For many affected people, this is a self-limited disease; for others, treatment results in a permanent cure. THE INSECTS. The stinging insects may be broadly divided into 2 families: the vespids, which include the yellow jacket, hornet, and wasp; and the apids, which include the honeybee and bumblebee. People may be allergic to one or all of the stinging insects. The identification of the culprit insect responsible for these reactions is very important in terms of specific advice and specific venom immunotherapy treatment discussed later. The honeybee and bumblebee are quite docile and tend to sting only when provoked. The ...
|Not only making a bee sting pain, swelling, and hot-cold body. If the sting carried out at certain points by people who know, some diseases, like rheumatism, high blood pressure, asthma can be cured. But do not try to sting if hiperalergi or suffering from complications of chronic heart failure, and liver, because it can be fatal. What…
The European Academy of Allergy and Clinical Immunology, EAACI, is an association including 47 European National Societies, more than 8,000 academicians, research investigators and clinicians.
For most people, an insect sting only causes redness, swelling and itching. However, for patients with allergies to these insects, insect venom can cause severe life-threatening reactions. An allergic reaction to an insect sting can involve your whole body and can start very rapidly after you are stung. Possible symptoms include dizziness, nausea, weakness, stomach cramps, diarrhea, hives, itching, or wheezing.
Being outdoors and frolicking in the grass is fun and refreshing until you get a bee sting. Bees are wonderful creatures that do so much for our environment. Nonetheless, bee stings can be painful, especially when it happens to your dog! When it happens to your dog, often times you will be left wondering what has happened as your dog is unable to verbally convey the message of course. Bee stings happen to dogs more often than you think! Weve all seen funny pictures of dogs whove been stung by bees with their swollen cheeks that are cute to look at but can be extremely painful for your pet!
Each episode resulted from several stings by more than one ant. This behavior is typical of fire ants, which will sting repeatedly until removed [3]. The first episode resulted in a local cutaneous reaction with erythema. The second episode resulted in the formation of a 1-cm bulla, lasting for a week and leaving a permanent scar. The third episode was systemic, with the development of a body rash, a feeling of faintness, tachycardia, and shortness of breath, and occurred within 15 minutes of the stings. Fortunately, an oral dose of diphenhydramine hydrochloride, 50 mg, caused the symptoms to resolve. The last episode resulted in two bullae of smaller size ...
Amyotrophic lateral sclerosis (ALS) is a paralyzing disorder characterized by the progressive degeneration and death of motor neurons and occurs both as a sporadic and familial disease. Mutant SOD1 (mtSOD1) in motor neurons induces vulnerability to the disease through protein misfolding, mitochondrial dysfunction, oxidative damage, cytoskeletal abnormalities, defective axonal transport- and growth factor signaling, excitotoxicity, and neuro-inflammation. Melittin is a 26 amino acid protein and is one of the components of bee venom which is used in traditional Chinese medicine to inhibit of cancer cell proliferation and is known to have anti-inflammatory and anti-arthritic effects. The purpose of the present study was to determine if melittin could suppress motor neuron loss and protein misfolding in the hSOD1G93A mouse, which is commonly used as a model for inherited ALS. Meltittin was injected at the ZuSanLi (ST36) acupuncture point in the hSOD1G93A animal model. Melittin-treated animals showed a
However, flonase side effects blood pressure a retrospective analysis of 79 patients who underwent hymenoptera venom (insect sting) allergy desensitization did not show an association between ACE inhibitor therapy and increased frequency of systemic reactions to venom immunotherapy! Patients randomized to lisinopril received 5 mg within 24 hours of the onset of symptoms, swiftly vega ukraine 5 mg after 24 hours, and then 10 mg daily thereafter! Meldonium, flonase prescription though, has been the subject of recent clinical work in several countries, generally in people whove had heart attacks or strokes? Please let me know if you have any kind of suggestions or tips for brand new aspiring blog owners! It is becoming increasingly accepted among doctors that sex hormone levels (Testosterone) should also be checked by way of a blood test! Om nuts! In addition to the authority practiced on individual plantations, claritin vs flonase slaves throughout the South had to live under a set of laws called ...
Case Reports: Here we describe three cases of massive bee envenomation, two of which were in geriatric patients. All patients were documented to have over 100 stings, with the highest one being a case of an 83 year old envenomated by over 400 Africanized honey bees (AB). All patients seemed to do well with supportive medical care, and were discharged from the hospital after 3-6 days of observation. The two geriatric patients were given epinephrine in the field and both had an increase in their Troponin I levels. It was not clear if this rise in Troponin I was an effect of epinephrine itself or a direct effect of the bee venom. Both geriatric patients were observed the longest in their Troponin I, and were released without any sequelae. Except for cases of anaphylaxis, we believe that these three cases show that supportive care is sufficient for patients with massive bee envenomation (over 100 stings ...
1) A life-threatening allergic reaction characterized by a swelling of body tissues including the throat, difficulty in breathing, and a sudden fall in blood pressure. (2) A widespread and very serious allergic reaction. Symptoms include dizziness, loss of consciousness, labored breathing, swelling of the tongue and breathing tubes, blueness of the skin, low blood pressure, heart failure, and death. Immediate emergency treatment is required for this type of shock, including administration of antivenom in the case of bee or wasp stings. (3) A sudden, life-threatening allergic reaction, characterized by dilation of blood vessels with a sharp drop in blood pressure and bronchial spasm with shortness of breath. Anaphylactic shock is caused by exposure to a foreign substance, such as a drug or bee venom, to which the individual has been previously exposed. The substances act as antigens, provoking a preliminary immune response during the first exposure that results in a full-blown, immediate response ...
For most individuals, insect stings cause immediate local reactions at the sting site and produce a temporary discomfort of redness, pain, itching and swelling lasting only a few hours. A large local reaction may be more painful with itching and swelling at the sting site and in surrounding areas that may last for a few days. For these latter two reactions, local skin care and occasionally oral antihistamines, corticosteroids and perhaps antibiotics may be required for relief. These reactions, however, do not necessitate venom skin testing and/or desensitization injections with venom extracts ...
Alan Lorenzo, Bee Well Therapy, Inc: Traveling Bee Venom Therapist serving the Northeast for the relief of symptoms from Arthritis, Bursitis, Tendonitis, Lyme Disease, M.S. and other spinal, neural, or musculo-skeletal ailments.
Serum IgG and IgG subclass antibody testing have been proposed as methods of identifying levels of sensitivity to various allergens, but there is disagreement in the medical community about how effective IgG antibody testing is for this purpose.. After evaluating the clinical literature, Harvard Pilgrim has found that while there is evidence to support the medical necessity of IgG testing for venom immunotherapy, there is not sufficient clinical evidence to support its use for other conditions, such as food allergy. As a result, effective July 1, 2014, Harvard Pilgrim will cover IgG and IgG subclass allergen testing for venom immunotherapy only. For more information, please refer to the Serum IgG Allergy Testing Medical Policy.. ...
We meet Jennifer Rubin as Janice Starlin, the aging owner of a cosmetics firm. She has ALWAYS been the model spokeswoman for her company, but now shes a little too wrinkled and elderly to carry this post on, or so her fellow owners think (including the delightfully smarmy Gerritt Graham). So Janice learns of a doctor (played quite woodenly by Daniel J. Travanti) who has found that using a serum made from bee venom can make one younger. He experiments on a little kitty cat he finds in the alley and lo and behold, the cat gets younger, not to mention the fact that the poor puss also turns into a beecat!!! Anyway, Rubin uses the serum and voila, shes young and beautiful again, but also has advanced cases of paranoid delusions, and oh, yes, when she gets really horny, she turns into the titular monstrosity. The movie is a true B movie, and captures the feel of those wonderfully overwrought films of the 50s. Rubin is effective as the wasp woman; Doug Wert as her main hunk Alec is heroically adroit; ...
Learn from this womans story about Lyme disease symptoms, pathology, and treatment, including Bee Venom Therapy. It could save a life!
From snail cream to bee venom, the beauty industry certainly has an obsession with obscure ingredients. But sometimes its the simple things that pack the mightiest punch. Take the humble seaweed, for example: The marine algae is currently making waves in the beauty world, thanks to a flurry of new…
I hope everyone had a nice summer. What are some of the perils/ dangers assoicated with the summer months that are most hazardous to you? For me #1 yellow jacket stings, I never know something that small can actually kill me, Im big time allergic. I know someone who died of an anaphylactic shock post bee sting #2 Sun- freckles arent that cute, they are giant melanocytes -| sun damage. #3 - others - the poison ivy - oak etc -| allergic reactions again PS: I mean bee sting
For most children, the reaction to a sting is short-lived, with redness and swelling followed by pain and itching. For others, however, the allergic reaction to an insect sting can be life threatening.
When it becomes warm again in spring and the first blossoms and bushes begin to bloom, the bees also begin to swarm. There is a lot to tell about bees that is worth knowing and is exciting and interesting.. Like ants and wasps, bees belong to the order of hymenoptera (membrane-winged). The bee family is divided into honeybees and bumblebees. It is especially interesting that bees live together in a large colony. There is a queen bee, and she is the only bee that lays eggs, from which the offspring are hatched. Besides a few males (the so-called drones), a bee colony consists primarily of female worker bees that have different tasks. During her life, a worker bee repeatedly takes on new tasks, depending on her age. At the beginning of her life, a bee looks after the honeycomb cells and prepares them for the queens eggs. She then becomes a nurse bee and feeds the larvae (= bee babies) with nectar. Later she can then produce wax with the glands on her posterior and build honeycombs. There are ...
Guides through decision to take shots for insect sting allergies. Describes different types of allergic reactions. Includes how allergy shots work. Covers benefits and risks. Includes an interactive tool to help you make your decision.
Another name for Allergy to Insect Stings is Allergic Reactions. Home care for an allergic rash includes: * Avoid contact with the substance that caused ...
Few of these venoms have been studied. They are a yet to be tapped resource for bioprospecting to find drugs with medical uses ... For defence, it can shoot venom from each or all of these spines. Each spine is like a hypodermic needle, delivering the venom ... Venomous fish carry their venom in venom glands and use various delivery systems, such as spines or sharp fins, barbs or spikes ... The stonefish has control over whether to shoot its venom, and does so when provoked or frightened. The venom results in severe ...
... has been practiced since the times of Hippocrates and Galen. Modern use of bee venom appears to have originated with ... Adverse reactions to bee venom therapy are frequent. Frequent exposure to the venom can also lead to arthropathy. In sensitized ... Bee venom or other honeybee products are ineffective for the treatment or prevention of cancer. In general, evidence for using ... practitioners claim ... bee venom can be used to treat various diseases, including several types of arthritis; neurological ...
The caterpillar has been responsible for many human deaths, especially in southern Brazil. Its venom has been the subject of ... As the spines penetrate the victim, venom flows through the hollow bristles and into the puncture wound. It was discovered that ... Pinto, A; Berger, M.; Reck Jr, J.; Terra, R.; Guimaraes, J. (15 December 2010). "Lonomia obliqua venom: In vivo effects and ... Since 1989 the number of human accidents caused by these caterpillars has been increasing in the southern region of Brazil. ...
... is an element in bee venom. You can come into contact with apamin through bee venom, so the symptoms that are known are ... Apamin is an 18 amino acid globular peptide neurotoxin found in apitoxin (bee venom). Dry bee venom consists of 2-3% of apamin ... Apamin was named after this bee. Bee venom contains many other compounds, like histamine, phospholipase A2, hyaluronidase, MCD ... The first symptoms of apitoxin (bee venom), that are now thought to be caused by apamin, were described back in 1936 by Hahn ...
In his hometown of Hamilton, Ontario a memorial statue of Frankie Venom had been planned but has been stalled because of ... Venom left the band to form a new group, Frankie Venom and The Vipers. Nick Stipanitz joined the Vipers as well. Venom was ... Stipanitz has since been replaced, and Venom died on October 15, 2008. The band's name is a reference to The Flaming Groovies' ... Frankie Venom quickly became the new vocalist, and Lewis recruited old friends Steve Mahon to play bass and Nick Stipanitz to ...
The composition of venom from a sting can even affect the types of treatment a patient should be given. Differences have been ... Polistes species are known to use stings and venom as a means of colony defense. However, this venom seems to be costly to ... While venom from a basic standpoint is used by solitary species to capture prey, it has served a greater purpose of defense in ... P. gallicus venom was found to be a combination of four major allergens: Ag5 (antigen 5), hyaluronidase, phospholipase, and ...
The venom of Uroplectes lineatus is clinically important in dermatology. Several scorpion venom toxins have been investigated ... Maurotoxin from the venom of the Tunisian Scorpio maurus blocks potassium channels. Some antimicrobial peptides in the venom of ... Several ships of the Royal Navy have been named HMS Scorpion, including an 18-gun sloop in 1803, a turret ship in 1863, and a ... The scorpion with its powerful sting has been used as the name or symbol of various products and brands, including Italy's ...
Its venom has been measured at 0.5 mg/kg subcutaneous. It is found in southeastern Australia, including Tasmania. A. superbus ... The venom of lowland copperhead contains postsynaptic neurotoxins. There have been a dozen reported bites from this species, ... It has been found in sandstone ridgetop woodland in the Blue Mountains, west of Sydney, where it is becoming rare, due to ... If provoked, the lowland copperhead is a dangerous snake with neurotoxic venom, which can kill an adult human if correct first ...
For A. andreniformis specifically, some commercial products include royal jelly, wax, honey, and bee venoms. Additionally, they ... As stated previously, the presence of royal jelly on young female larva produced the queen bee. Drones, or male bees, are not ... Apis andreniformis, or the black dwarf honey bee, is a relatively rare species of honey bee whose native habitat is the ... The genus Apis includes honey bees, the most common being Apis mellifera, otherwise known as the Western honey bee. A. ...
In this account, the deposed Prince had been made to drink "venom". A similar narrative is provided by Weiß, who further ... if they had been true, they would also have been taken up in political literature. His version, based on theories circulated by ... Stanca may have been an ethnic Turk and a Muslim apostate whose original name was Sultana, and was perhaps also a renegade ... His second or non-regnal name, rendered as Emanuel or Emanoil, has been deduced from a German-language document dealing with ...
The agatoxin in their venom has been studied extensively in Agelenopsis aperta. Once the prey has been disabled, the spider ... There have been a few cases of bites in Southern California by the desert grass spider, Agelenopsis aperta, that resulted in ... However, no trophallaxis occurs, nor any true eusociality such as occurs in the social Hymenoptera (ants, bees, and wasps); for ... and Hemolytic Potential of Venom from the Hobo Spider, Eratigena agrestis (Araneae: Agelenidae)". Journal of Medical Entomology ...
In addition there have been undocumented descriptions of venom glands in Solifugae. Chemical defense has been found in whip ... Scorpion venom' attacks tumours", BBC News, 2006-07-30, retrieved 2008-10-25 Scorpion venom blocks bone loss, Harvard ... Although the venom of a few spider and scorpion species can be very dangerous to humans, medical researchers are investigating ... Spider venoms may be a less polluting alternative to conventional pesticides as they are deadly to insects but the great ...
Tanu, who has been poisoned with narcoblix venom, chases Kendra into the woods. Kendra heads to find Lena with the water nymphs ... He tells them that they have been keeping an eye on the two Sorenson children and that he can get rid of the problem creature. ... Dale takes the children to a cottage, where his brother Warren has been in a catatonic state for years after visiting a grove ... Fablehaven: Rise of the Evening Star's reception has mainly been positive, along with the other books in the series. Many other ...
However, there has been little research on the venom produced by this species. Blackbelly rosefish have intraovarian gestation ... They have been recorded at depths between 50 and 1,100 m (160 and 3,610 ft), but usually from 150 to 600 m (490 to 1,970 ft). ... Although there has been little commercial interest in this species, partially due to its low level of accessibility, it is ... As with other species of scorpionfish, the spines of the blackbelly rosefish contain toxic venom and have reportedly caused ...
Roberts, Terry (2017-05-12). "'My inbox has never been so full of venom': embattled Noreen Golfman responds". CBC News. ... This campus has been a popular location for internships in education, and now offers credit courses, work terms, and ... A former schoolhouse and a teacher's cottage have been converted into a lecture facility and an apartment and a former shop has ... John's Police Department, whilst the rest of the campus has been used to portray the equally fictional Heritage University of ...
Additionally, several compounds that have been identified in their venom function as alarm pheromones in other species of ... ISBN 978-3-642-32680-6. Maschwitz, U. (1971). "Morphology and function of the venom apparatus of insects ± bees, wasps, ants ... Autotomy is a common phenomenon in bees and has also been found to occur in several wasp species of the tribes Epiponini and ... It has been shown that the majority of cells are bottomless with a maximum length of 0.7 cm, with only the most recently built ...
Nothing is known of its behavior, as less than 20 specimens have ever been collected. Nothing is known of the venom composition ... and no bites have ever been recorded. McDiarmid RW, Campbell JA, Touré T. 1999. Snake Species of the World: A Taxonomic and ...
The test is done to assess allergies to drugs like penicillin or bee venom. To ensure that the skin is reacting in the way it ... but the vast majority of these tests have no validity and have never been proven to work scientifically. RAST test Basophil ...
Bands like Venom, Slayer, Celtic Frost, Voivod, and Darkthrone have been noted as influences also. The name "Superjoint Ritual ...
Snake venom appears to have been 'prescribed' in some cases as a form of therapy. The staff has also been variously interpreted ... Theories have been proposed about the Greek origin of the symbol and its implications. The Rod of Asclepius takes its name from ... It has been claimed that the snake wrapped around the staff was a species of rat snake, Elaphe longissima, the Aesculapian ... The significance of the serpent has been interpreted in many ways; sometimes the shedding of skin and renewal is emphasized as ...
Venoms from hymenoptera species have been used in Chinese, Korean, and ancient Greek and Egyptian traditional medical practices ... Larval wasps rely on the paralyzed bees as a food source when they emerge. Paralyzed bee-prey may be stored for some length of ... August 2015). "Pharmacological Alternatives for the Treatment of Neurodegenerative Disorders: Wasp and Bee Venoms and Their ... Analogues with IC50 values in the low nano-molar and pico-molar range have been identified and studied. Combined with the ...
Certain wasp and bee venoms contain phospholipases that enhance the effects of injury and inflammation delivered by a sting. As ...
This rhetorical device has been adopted to inject facts with the venom of a disturbing quality. Against all principles of ... knowing that they will be defeated by an enemy whose values have been accepted as a necessary and exhilarating duty. The ... Cefalonia 1943-2001 has been translated into English and Spanish. Before its complete publication by Mondadori, the poem was ...
Although rear-fanged, all species are considered harmless, but their venom has not been well studied. They should not be ...
"Ice Cold Man" has also been played by Cathedral on their 2004 tour. "Centuries of Sin" has also been played by Venom on their ... VENOM Singer Comments On PROBOT Project: 'This Was Heavy Shit!' [1] Dave Grohl's League Of Extraordinary Gentlemen Dave Grohl ... According to Grohl, the songs sent to Eric Wagner and King Diamond had been previously done for Ozzy Osbourne as he was ... Had Dave Grohl used more guest musicians instead of trying to do everything himself, Probot would have been much better." ...
This is also the group in which venom has been developed in several lines of snakes. Below is a phylogeny of Afrophidia ...
It has also been isolated from the venom of North American prairie rattlesnake, Crotalus viridis viridis. It was first isolated ... The gene has been previously isolated in the C. durissus terrificus genome and the protein itself belongs to a group of small ... When comparing the amino acid sequences of other proteins not in the SBPM family found in snake venoms, there is usually large ... Crotamine is a toxin present in the venom of the South American rattlesnake (Crotalus durissus terrificus). It is a 42-residue ...
Peafowl have been kept for millennia due to their ophiophagous habit. Many ophiophagous animals seem to be immune to the venom ... The Virginia opossum (Didelphis virginiana) has been found to have the most resistance towards snake venom. This immunity is ... However, recent studies have shown that the mongoose's ability to resist snake venom is at least in part due to its modified ...
This small species possesses a potent venom, and human fatalities from its bite have been recorded. Four subspecies are ...
Single-chain variable fragments (scFvs) have been used to recognize and neutralize Cn2 from Centruroides noxius venom. ... This scorpion produces a venom in which the Cn2 toxin is the most abundant component; it comprises approximately 6.8% of the ... Possani LD, Dent MA, Martin BM, Maelicke A, Svendsen I (1981). "The amino terminal sequence of several toxins from the venom of ... However, many functional variations of these peptides have been demonstrated, with almost 10 different toxin subgroups that can ...
having been in a country with widespread Ebola disease transmission and having no known exposure (low risk); or having been in ... "J Venom Anim Toxins Incl Trop Dis. 20 (1): 44. doi:10.1186/1678-9199-20-44. PMC 4197285. PMID 25320574.. ... has not been observed.[59][60] No spread by mosquitos or other insects has been reported.[59] Other possible methods of ... Bushmeat having been smoked in Ghana. In Africa, wild animals including fruit bats are hunted for food and are referred to as ...
Low-quality evidence suggests topical application of tea tree oil or bee venom may reduce the total number of skin lesions in ... There is no clear evidence to support some of these claims.[1][20] Isotretinoin has been found in some studies to be superior ... Studies investigating the impact of smoking on the incidence and severity of acne have been inconclusive.[2][38][39] Sunlight ... The term nodulocystic has been used in the medical literature to describe severe cases of inflammatory acne.[25] True cysts are ...
... es have also been observed in what has been described as play: repeatedly releasing bottles or toys into a circular ... The venom appears to be able to penetrate the skin without a puncture, given prolonged contact. It contains tetrodotoxin, which ... The terrifyingly powerful Gorgon of Greek mythology has been thought to have been inspired by the octopus or squid, the octopus ... They have been reported to practise observational learning,[87] although the validity of these findings is contested.[83][84] ...
One unusual cause of focal hyperalgesia is platypus venom.[5]. Long-term opioid (e.g. heroin, morphine) users and those on high ... The use of a transcutaneous electrical nerve stimulation device has been shown to alleviate hyperalgesia.[28][29] ... Where hyperalgesia has been produced by chronic high doses of opioids, reducing the dose may result in improved pain management ... "Venom from the platypus, Ornithorhynchus anatinus, induces a calcium-dependent current in cultured dorsal root ganglion cells" ...
Although there has been an increase in the maximum level of complexity over the history of life, there has always been a large ... This process has been sometimes described as a complexifying ratchet.[23] These supplemental genes can then be co-opted by ... If this decay results in a situation where all of the genes are now required, the organism has been trapped in a new state ... Constructive neutral evolution has also been used to explain how ancient complexes, such as the spliceosome and the ribosome, ...
... in which bee venom and acetic acid was injected into the lips of rainbow trout, resulted in fish rubbing their lips along the ... Grasshoppers, bees and even ants are also used as bait for trout in their season, although many anglers believe that trout or ... and also that some fish will re-take a lure they have just been hooked on, a behaviour that is unlikely if hooking were painful ...
Some carbons have been able to achieve bonding energies of 5-10 kJ per mol. The gas may then be desorbed when subjected to ... Adsorption rates for H2S as high as 50% by weight have been reported.[citation needed] ... Some of the chemical properties of activated carbon have been attributed to presence of the surface active carbon double bond.[ ... Molasses Number is a measure of the degree of decolorization of a standard molasses solution that has been diluted and ...
... which use venom to attack. The venom is modified saliva, delivered through fangs from a venom gland.[124][125] Some non- ... The oldest known animal that may have been an amniote is Casineria (though it may have been a temnospondyl).[35][36][37] A ... Further information: Venom and Evolution of snake venom. Camouflage does not always fool a predator. When caught out, snake ... It has largely been abandoned by recent researchers: in particular, the anapsid condition has been found to occur so variably ...
This friendship would have been impossible had Elisha been an apostate or a man of loose morals,[dubious - discuss] as has been ... "like the venom of a snake".[9] ... "We have been taught that in heaven there is no sitting.... ... Acher saw that Metatron had been granted authority to sit while he record the merits of Israel, and he said: " ...
Could've Been von H.E.R. featuring Bryson Tiller (Autoren: Dernst Emile II, David Harris, Gabriella Wilson, Hue Strother) ... Venom & Faith von Larkin Poe. *Brighter Days von Robert Randolph and the Family Band ...
Until recently, their venom has often been regarded as less toxic than that of many other species, perhaps because bites are ... Venom[edit]. Not much is known about their venom except that it is mainly neurotoxic. Besides the neurotoxins, they also carry ...
For fish that produce venom harmful to humans, see Venomous fish.. Fish toxins or fish stupefying plants have historically been ... Many of these plants have been used for a long time by local people, and have been tested and found to have medicinal ... Use of the herbal fish poisons has been documented in a number of sources involving catching fish from fresh and sea water.[3] ... In 1212 AD, King Frederick II prohibited the use of certain plant piscicides, and by the 15th century, similar laws had been ...
They have been found to hydrolyse.[16] Because of their distinctive properties, ionic liquids have been investigated for many ... alkaloid-based venom. The Tawny crazy ant then exudes its own venom, formic acid, and self-grooms with it, an action which de- ... toxifies the Fire ant venom. The mixed venoms chemically react with one another to form an ionic liquid, the first naturally ... ILs and amines have been investigated for capturing carbon dioxide CO. 2 and purifying natural gas.[54][55][56] ...
Larger species have been known to prey on small lizards, frogs, birds,[2] snakes, and even rodents. ... Mantids bite, but have no venom, and are not dangerous to humans. They are not chemically protected; nearly any large predatory ...
Predigestion avoids exposure to internal parasites.[5] Several groups secrete venom from specialized glands to kill prey or ... The next pair of appendages, the pedipalps have been adapted for feeding, locomotion, and/or reproductive functions. ...
The patient on initial screening will typically have been found to have a prolonged APTT that does not correct in an 80:20 ... dilute Russell's viper venom time (DRVVT), kaolin clotting time (KCT), dilute thromboplastin time (TDT/DTT), silica clotting ... is the first-ever international research network that has been created to design and conduct large-scale, multicenter clinical ...
During these studies Calmette discovered that the power of the venom, as well as that of tetanus, could be annihilated by the ... For over a century, the Institut Pasteur has been at the forefront of the battle against infectious disease. This worldwide ... Since 1908, eight Institut Pasteur scientists have been awarded the Nobel Prize for medicine and physiology, and the 2008 Nobel ... Over the years, it has been responsible for breakthrough discoveries that have enabled medical science to control such virulent ...
... has been hired by Walter Declun (a former member of Damage Control) to assist Absorbing Man, Hydro-Man, Killer ... Agent Venom/Anti-Venom (Flash Thompson). *Uncle Ben. *Ben Urich. *Mary Jane Watson ... The Master Programmer was revealed to be a digitized copy of Doctor Octopus' mind and Carolyn's overall plan had been to allow ... After Spider-Man defeated her, she learned she had been manipulated and sought revenge. To achieve this, she and Spider-Man ...
Bites are similar to a bee's sting, with its venom causing redness and mild to severe swelling.[3][14] ... In South Africa, they have been found in the Western Cape, in and around Cape Town (sightings have been reported in Pinelands; ... They have been found in eastern and southern Australia, from Perth to Adelaide, South Australia, to Sydney, New South Wales and ... They administer venom through forcipules. These are not part of their mandibles, so strictly speaking they sting rather than ...
... which had been specially designed to produce B-24s. For the rest of the war, Bell's Marietta plant, under the management of ... and during World War I had been considered the largest airplane factory in the world. ...
Gaucher recommended treatment with cobra venom. Boinet, in 1913, tried increasing doses of bee stings (up to 4000). Scorpions ... It has been said that promin was first synthesised in 1940 by Feldman of Parke-Davis and company.[34] Although Parke-Davis ... It has also been used in China and Burma. It was introduced to the West by Frederic John Mouat, a professor at Bengal Medical ... It may have been caused by a fungus, but he is being cared for by three officials of a charitable home intended for leprosy ...
Venom[edit]. The sting and associated venom sac of honey bees are modified so as to pull free of the body once lodged (autotomy ... Africanized bee[edit]. Main article: Africanized bee. Africanized bees (known colloquially as "killer bees") are hybrids ... "Bee castes". Visual Dictionary, QA International. 2017. Retrieved 18 May 2017.. *^ a b c d e f g h "Getting Started: Honey Bee ... bumble bees, other native bees. The stingless bees mentioned by Jefferson are distant relatives of the honey bees, in the genus ...
Similar effects have been found in the hippocampus, substantia nigra, and cerebellum granule cells of rats and mice.[5] ... AmmTX3 (α-KTX15.3) is a peptide that can be isolated from the venom of Androctonus mauretanicus.[1] Androctonus mauretanicus is ... Bougis, PE; Martin-Eauclaire, MF (25 June 2015). "Shal-type (Kv4.x) potassium channel pore blockers from scorpion venoms". ... This subfamily currently exists of six very homologous peptides, originating from scorpion venom: Aa1, AaTX1, AaTX2, AmmTX3, ...
The naming of enzymes by adding the suffix "-ase" to the substrate on which the enzyme acts, has been traced to French ... Duclaux E (1899). 》Traité de microbiologie: Diastases, toxines et venins》 [Microbiology Treatise: diastases, toxins and venoms] ...
This receptor has been also described to play a role in inflammation.[10] Most recently, it has been shown that the kinin B1 ... Bradykinin was detected in the blood plasma of animals after the addition of venom extracted from the Bothrops jararaca ( ... It has long been known in animal studies that bromelain, a substance obtained from the stems and leaves of the pineapple plant ... Bradykinins have been implicated in a number of cancer progression processes.[16] Increased levels of bradykinins resulting ...
It has been hypothesized that, by helping degrade the ECM surrounding the tumor, hyaluronidases help cancer cells escape from ... Hyaluronidases are found in the venom of certain lizards and snakes, as well as honeybees, where they are referred to as " ... The role of hyaluronidases in cancer has been historically controversial due to contradictory observations,[11] namely that ... Non-specific inhibitors (apigenin, sulfated glycosaminoglycans) or crude enzyme extracts have been used to test most hypotheses ...
Cronos of Venom. Venom are considered precursors of both black metal and thrash metal.[305] ... The UK had been a home for music video pioneers. When the music video cable channel MTV started broadcasting in 1982, the ... Sounds gave Metal for Muthas a poor review, but the album was nevertheless a commercial success[192] and may have been ... NWOBHM bands had been touring steadily in the United States, but had not yet received enough FM radio airplay there to make a ...
B. boehmei has been described as the "most gorgeous" species of the genus. The parts of the legs closest to the body are black ... relying on their venom and their size and strength. Larger species of Brachypelma, such as B. smithi, have body lengths in the ... All the species of Brachypelma that have been studied in detail live in burrows. These have a single entrance, a little larger ... The taxonomy of the genus and its species has been the subject of considerable debate. As of October 2017[update], the genus ...
Venom and toxins[edit]. The venom of the many-banded krait consists of both pre- and postsynaptic neurotoxins (known as α- ... Since the species' description by zoologist and pharmacist Edward Blyth in 1861,[3][5] Bungarus multicinctus has been the ... The average venom yield from specimens kept on snake farms is about 4.6 mg-19.4 mg per bite.[15] The venom is highly toxic with ... White; Meier, J;J (1995). Handbook of clinical toxicology of animal venoms and poisons. CRC Press. pp. 493-588. ISBN 978-0-8493 ...
Both groups have been credited with inspiring the subgenre's name, the latter via its 1984 demo Death Metal and the song "Death ... "Slayer's music was directly responsible for the rise of death metal," according to MTV News.[219] The NWOBHM band Venom was ... Several attempts have been made to map the complex world of underground metal, most notably by the editors of AllMusic, as well ... It has been argued that heavy metal has outlasted many other rock genres largely due to the emergence of an intense, ...
2. Does venom collection kill bees? Bee venom can be collected without killing bees. During the 1950s and 1960s, venom ... Freeze-drying is perhaps the most effective method of preserving bee venom. 4. What is bee venom used for? Bee venom is a rich ... It is on bee venom therapy and I have the permission of the author to post it here. Bee Venom - Frequently Asked Questions Bee ... 8. Is bee venom solution as effective as bee stings? Bee venom has many active components, however, during its collection it ...
Bee venom can have a positive impact on your skin -- and a new line of skin care products is bringing those benefits to you ... Bee Venom Moisturiser (Nordstrom, $190). Bee Venom Moisturiser is an advanced formula that uses bee venom, plant stem cells and ... on bee venom. Would you let a bee sting you on purpose? Probably not, but apparently bee venom can have a positive impact on ... Bee Venom Eye (Nordstrom, $140). Bee venom works in synergy with plant stem cells to help visibly improve skin tone and ...
Learn about the potential benefits of Bee Venom including contraindications, adverse reactions, toxicology, pharmacology and ... Experimental injection of bee venom caused a reaction similar to that observed in patients with bee venom-induced ARF. 22 ... These results suggest that bee venom-induced apoptosis contributes to growth inhibition of U937 cells. Bee venom-induced ... Bee venom is used to hyposensitize individuals highly sensitive to bee stings. There is some evidence that it might also help ...
... brighten dark circles and firm the skin with bee venom, stem cell technology and melittin peptide. ... brighten dark circles and firm the skin with bee venom, stem cell technology and melittin peptide. Bee venom stimulates blood ... brighten dark circles and firm the skin with bee venom, stem cell technology and melittin peptide. Bee venom stimulates blood ... Bee Venom.. Cautions: Do not use if you have an allergy to bee stings. A patch test prior to use is recommended. If signs of ...
Buy skinChemists Bee Venom Treatment Set (Worth £184.79) today at IWOOT. We have great prices on gifts, homeware and gadgets ... Bee Venom Facial Serum:. Combining real bee venom with aquaxyl and hyaluronic acid, the facial serum works to improve nutrient ... Bee Venom Eye Serum:. This rejuvenating eye serum combines real bee venom with hyaluronic acid to counteract dark circles and ... Bee Venom Duo Moisturiser:. This moisturiser combines real bee venom with manuka honey and hyaluronic acid to intensely nourish ...
Rodial Bee Venom 24 Hour Carat Gold Body. As a part of the Rodial Bee Venum collection, this body soufflé is deeply ... This indulgent, high performance formula is enforced with double-strength Bee Venom and Liquid Gold. Delivering a cocoon of ...
Camilla, Duchess of Cornwall, reportedly slathers on a $90 bee venom-based face mask to combat the aging process. This organic ... Graf, but there havent been enough clinical trials to judge the effect of the venom. With repeated use, it could cause you ... Camilla, Duchess of Cornwall, reportedly slathers on a $90 bee venom-based face mask to combat the aging process. This organic ... Graf says melittin, the active compound in bee venom, does have anti-bacterial and anti-inflammatory properties, and can boost ...
Bee venom injections are used for desesentization treatments against allergies to bee venom. Usually, patients are injected ... This study would pave the way for a first clinical trial, which would be fairly easy to organize since bee venom injections are ... These researchers wish to know whether bee venom and/or its constituent, apamine, are able to slow or halt the disease process ... Researchers verified, in a pre-clinical model of the disease, that bee venom and one of its components, apamine, are able to ...
The underlying mechanisms of the anti-inflammatory and analgesic actions of BV have been proved to some extent. Additionally, ... has long been used in Korea to relieve pain symptoms and to treat inflammatory diseases, such as rheumatoid arthritis. ... Keywords: Bee Venom; immunological diseases; neurological diseases Bee Venom; immunological diseases; neurological diseases ... Bee Venom (BV) has long been used in Korea to relieve pain symptoms and to treat inflammatory diseases, such as rheumatoid ...
Cougar By Paula Bee Venom Purifying Face Mask Plump And Rejuvenate 100ml for sale on Trade Me, New Zealands #1 auction and ... Bee Venom is an active ingredient which works to diminish fine lines and wrinkles on the skins surface. Once applied, Bee ... Cougar By Paula Bee Venom Purifying Face Mask Plump And Rejuvenate 100ml. ... Cougar By Paula Bee Venom Purifying Face Mask Plump And Rejuvenate 100ml ...
Over the last few years bee researchers have found that bee venom has some of the most powerful anti - aging properties known ... Been venom moisturiser 100g Wild Fern. Bee Venom Moisturiser - Wild Ferns - 100g. ... The reviews on bee venom are numerous and for people who are not allergic to bee products the response has been fantastic. ... Bee Venom moisturiser by Wild Ferns 100g. In recent times advances in anti-aging research has yielded amazing results from work ...
Bee Products. Honey (2133) Propolis (1416) Apitherapy and Beekeeping (971) Bee Venom (899) Royal Jelly (655) Bee-Collected ... Bee Venom Boosts Wound Healing Bee Venom Accelerates Wound Healing in Diabetic Mice by Suppressing Activating Transcription ... Bee venom (BV) has been used as an anti-inflammatory agent for the treatment of several diseases. Nevertheless, the effect of ... Apitherapy News - The Internets Best Source of Information About the Medicinal Use of Bee Products ...
Bee venom and phospholipase A2 extracted from bee venom enhanced guanylate cyclase (E.C. 4.6.1.2) activity two- to threefold in ... Dose-response relationships revealed that bee venom at concentrations as low as 1 microgram per milliliter and phospholipase A2 ...
To assess the effects of bee venom in chronic liver disease, we investigated the potential role of the bee venom in the ethanol ... Bee venom (Apis mellifera) has been traditionally used for the treatment of various chronic diseases, such as chronic ... With ethanol treatment, bee venom-treated hepatocytes increased activity of Bcl-2 and Bcl-xL, reduced activity of Bax, Caspase ... Woo-Ram Lee, Sok Pak, Kwan-Kyu Park, The Protective Effect of Bee Venom on Fibrosis Causing Inflammatory Diseases, Toxins, 2015 ...
Bee venom acupuncture (BVA) has been used to attenuate pain, and its effect is known to be mediated by spinal noradrenergic and ... Keywords: bee venom acupuncture; chemotherapy induced neuropathic pain; morphine; oxaliplatin bee venom acupuncture; ... Bee venom acupuncture (BVA) has been used to attenuate pain, and its effect is known to be mediated by spinal noradrenergic and ... Combined Effects of Bee Venom Acupuncture and Morphine on Oxaliplatin-Induced Neuropathic Pain in Mice. Woojin Kim 1,2. ...
... is a conserved component of venoms from multiple species and is the major allergen in bee venom. Here we examined how bee venom ... Crotalus atrox venom or Agkistrodon contortrix venom (E) OVA, Crotalus adamanteus venom, or Crotalus adamanteus PLA2. (B) PLA2 ... We found that bee venom PLA2 induced a T helper type 2 (Th2) cell-type response and group 2 innate lymphoid cell activation via ... Bee venom phospholipase A2 induces a primary type 2 response that is dependent on the receptor ST2 and confers protective ...
Nanoparticles carrying a toxin found in bee venom can destroy human immunodeficiency virus (HIV) while leaving surrounding ... Bee venom contains a potent toxin called melittin that can poke holes in the protective envelope that surrounds HIV, and other ... Nanoparticles carrying a toxin found in bee venom can destroy human immunodeficiency virus (HIV) while leaving surrounding ...
bee venom. bvPLA2. bee venom phospholipase A2. COX. cyclooxygenase. DA. dopaminergic. DC. dendritic cell. MPTP. 1-methyl-4- ... An overview of bee venom acupuncture in the treatment of arthritis. Evid. Based Complement. Alternat. Med. 2: 79-84. ... Regulatory action of bee venom on the humoral immunity system]. Nauchnye Doki. Vyss. Shkoly Biol. Nauki 1982: 41-45. ... Bee venom phospholipase A2 is recognized by the macrophage mannose receptor. Arch. Biochem. Biophys. 324: 78-84. ...
... effects of peripheral NMDA and non-NMDA receptors on response of persistent nociception induced by subcutaneous bee venom ... effects of peripheral NMDA and non-NMDA receptors on response of persistent nociception induced by subcutaneous bee venom ... effects of peripheral NMDA and non-NMDA receptors on response of persistent nociception induced by subcutaneous bee venom ... effects of peripheral NMDA and non-NMDA receptors on response of persistent nociception induced by subcutaneous bee venom ...
... around 30 percent of managed honey bee colonies in US have collapsed, but role of pesticides remains unclear ... Bee colony collapse is a phenomenon in which masses of bees never find their way back to the hive.. In the United States, ... The researchers fed "acute and chronic doses" of the pesticide to bees and found it only had a "very slight effect on the bees ... Case in point: Fungicides are not considered toxic to bees. But growing evidence shows that bees exposed to them are more ...
Bee venom contains a powerful toxin called melittin which can perforate the viral envelope of HIV (human immunodeficiency virus ... Nanoparticles containing bee venom toxin melittin can destroy human immunodeficiency virus (HIV) while at the same time leaving ... Bee Venom Destroys HIV And Spares Surrounding Cells. Written by Christian Nordqvist on March 11, 2013 ... tumor Journal of the Science of Food and Agriculturehoney-bee products, including venom, could well have applications in cancer ...
Bee venom and its major component, melittin, may be effective treatments for atopic dermatitis (or eczema), according to a ... Bee venom and its major component, melittin, may be effective treatments for atopic dermatitis (or eczema), according to a ... Through studies conducted in mice and in human cells, investigators found that bee venom and melittin suppress inflammation ... "This study demonstrated that bee venom and melittin have immunomodulatory activity, and such activity was associated with the ...
He started out allergic to bee stings and overcame the dangerous allergy. Learning about how to tolerate bee stings is part of ... Tags: BeeWeaver, beekeeping, stings, bee stings, Africanized bees, bee basics, keeping bees, bee sting allergy, anaphylactic ... I was sensitized to bee proteins and my immune system was primed to mount a full court press against bee venom. The result was ... I was born the son of a beekeeper, who was a son of beekeeper, who was a son of beekeeper, who was….. Anyway, the bee venom ...
Nanoparticles carrying a toxin found in bee venom can destroy human immunodeficiency virus (HIV) while leaving surrounding ... Bee venom contains a potent toxin called melittin that can poke holes in the protective envelope that surrounds HIV, and other ... Nanoparticles carrying a toxin found in bee venom can destroy human immunodeficiency virus (HIV) while leaving surrounding ...
Ever since the Venom inspired outer layers have been trending on the internet, its a sin not to invest in such outfits. Read ... But the one that has been able to receive widespread recognition and appreciation all across the world is Venom. ... Venoms Casual Choice. As half of the film revolves around the private life of Brock before he turns into a monster, most of ... When Venom landed in the cinemas with all the hype and speculations, fans were impressed with the idea of anti-hero character ...
... honey bee venom had no beneficial effect against the course of EAE, and some of the mice treated with bee venom experienced a ... Preliminary Test Results Of Bee Venom In Mice With Ms-Like Disease May 8, 1998. They studied the effect of bee venom on mice ... a worse course of disease after receiving honey bee venom raises possible safety concerns for the use of honey bee venom ... by allowing bees to sting her. She calls this bee-venom therapy (BVT) and believes it has saved her from MS. ...
Bee, Cell Biology, Cell Signaling and Neuroscience, Ion Channel Modulating Peptides, Ion Channels, Monovalent Ion Channels, ... Peptides and Proteins, Peptides for Cell Biology, Potassium Channel Modulators, Toxins and Venoms, Voltage-gated Ion Channels ...
New research in the FASEB Journal shows that a peptide derived from bee venom can deliver liposomes bearing drugs or diagnostic ... The next time you are stung by a bee, heres some consolation: a toxic protein in bee venom, when altered, significantly ... Nanoparticle Smart Bomb To Target Cancer Cells Created From Novel Bee Venom Derivative. Written by undefined on Invalid date ... New research in the FASEB Journal shows that a peptide derived from bee venom can deliver liposomes bearing drugs or diagnostic ...
Effectiveness of acupuncture and bee venom acupuncture in idiopathic Parkinsons disease.. Cho SY1, Shim SR, Rhee HY, Park HJ, ... Participants in the bee venom acupuncture group showed significant improvement on the Unified Parkinsons Disease Rating Scale ... This study aimed to explore the effectiveness of both acupuncture and bee venom acupuncture as adjuvant therapies for ... They were randomly assigned to 1 of 3 groups: acupuncture, bee venom acupuncture, or control. All participants were assessed ...
Wasp and Bee Venom official prescribing information for healthcare professionals. Includes: indications, dosage, adverse ... Hymenoptera Venom Products available are sterile freeze-dried venom of Honey Bee (Apis mellifera) and venom protein of Yellow ... HONEY BEE HYMENOPTERA VENOM MULTIDOSE honey bee hymenoptera venom multidose injection, powder, lyophilized, for solution. ... Wasp and Bee Venom - Clinical Pharmacology. Diagnosis. Diluted solutions of stinging insect venoms injected intradermally will ...
A new study has shown that bee venom can kill the human immunodeficiency virus (HIV). Researchers at Washington University ... Bee Venom Kills Hiv Bee Venom Cures Bees Been Venom Hiv Hiv Treatement ... The bee venom HIV study was published on Thursday in the journal Antiviral Therapy, according to U.S. News & World Report. ... Louis have demonstrated that a toxin called melittin found in bee venom can destroy HIV by poking holes in the envelope ...
Beekeeping contributes to supporting sustainable livelihoods in poor and remote communities and honey bees provide an essential ... Bees for Development is an international charity, specialised in alleviating poverty through beekeeping. ... No smoke can be used when collecting the venom because of the risk of contamination. The venom is also very irritating to the ... Bee stings. Holm E., published 2001, Bees for Development Journal 61 11 PDF on this website ...
... Day and night body serum to help nourish and lift the appearance of skin with retinol and bee venom ... Day and night body serum to help nourish and lift the appearance of skin with retinol and bee venom melittin peptide. An ... Key benefits: melittin peptide: bee venom plumps and firms wrinkle appearance slow release retinol: to resurface and improve ... Bee Venom, Disodium EDTA, Tocopherol , Laureth-7, Lecithin, Retinol, Dehydroacetic Acid, BHT, BHA, Alpha-Isomethyl Ionone, ...
... pollen and venom. Bee venom therapy uses the venom from bees to treat ailments that dont respond to traditional Western ... bee therapy is the medicinal use of products made by honeybees, such as honey, ... Bee venom therapy uses the venom from bees to treat ailments that dont respond to traditional Western medicine. Bee venom is ... attributing healing and abatement of symptoms to bee venom. In addition to pain relief, individuals claim that bee venom has ...
Bee venom acupuncture (BVA), a treatment method of injecting bee venom (BV) into one or more acupoints, has been used ... Bee venom acupuncture (BVA) has been used in Korea to relieve various pain symptoms and is shown to have a potent antiallodynic ... Effect of Bee Venom Acupuncture on Oxaliplatin-Induced Cold Allodynia in Rats. Bong-Soo Lim,1 Hak Jin Moon,1 Dong Xing Li,2 ... S. Y. Kang, D. H. Roh, J. H. Park, H. J. Lee, and J. H. Lee, "Activation of spinal α2-adrenoceptors using diluted bee venom ...
... brighten dark circles and firm the skin with bee venom, stem cell technology and melittin peptide. ... brighten dark circles and firm the skin with bee venom, stem cell technology and melittin peptide. Bee venom stimulates blood ... brighten dark circles and firm the skin with bee venom, stem cell technology and melittin peptide. Bee venom stimulates blood ... Bee Venom.. Cautions: Do not use if you have an allergy to bee stings. A patch test prior to use is recommended. If signs of ...
Does the Abeeco Bee Venom Mask actually work? Click here to read the full review from Truth In Aging experts and find out for ... Abeeco Bee Venom Mask Review. is a Solution for: Dull Skin, Fine Lines, Sagging Skin, Wrinkles ... My other bee venom mask featured it second. Considering this product tends to be a bit more pricy than some of the others, I ... As the current is activated, the bees perceive it as a threat and sting away, squirting small amounts of venom onto the glass ...
... venom and a protein from the snowdrop plant, was bee-friendly. ... Venom from one of the worlds most poisonous spiders may help ... Neither adult bees nor larvae were affected, said the study published in the journal Proceedings of the Royal Society B.. The ... Bees account for 80 percent of plant pollination by insects. Without them, many crops would be unable to bear fruit or would ... Venom from one of the worlds most poisonous spiders may help save the worlds honeybees, a study has shown. ...
Thermo Scientific ImmunoCAP Venom Allergens Honey bee Diagnostic Tests and Clinical Products:Diagnostic Tests and Controls: ... In clinical practice, 0.35 kUA /l has commonly been used as a cut-off. A large number of studies have been performed to ... Thermo Scientific ImmunoCAP Venom Allergens Measure specifc IgE antibodies using ImmunoCAP allergens, an essential tool to aid ... Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your ...
Cancer cure? Venom from snakes, scorpions and Bees studied. * George Brown and CNN Wire ... In 14 BC, the Greek writer Pliny the Elder described the use of bee venom as a cure for baldness. ... Pans technique uses nanotechnology to deliver a synthesized element similar to the venom found in bees, snakes and scorpions. ... Beestings, for example, hurt and become inflamed because melittin, the main toxin in a bees venom, destroys cell membranes. ...
Buy Rodial Bee Venom Moisturizer (50ml) at SkinCareRX! We have the best range of Rodial Skin Care products online. Free ... Rodial Skincare Bee Venom Moisturizer renews and revitalizes skin for naturally healthy and younger-looking skin. Bee venom ... I have been using the bee venom moisturizer for 2 years now and LOVE it, really effective and has kept my face looking years ... How will I know it has been sent. You will receive an email to confirm when your item has been sent. ...
When researching bee venom for medical purposes, scientists begin with dry bee venom. When exposed to air, venom dries into ... The allergen in bee venom that causes the main "ouch" is melittin. Its by far the most abundant ingredient in bee venom - 50% ... Bee venom is a toxin, so a scientific approach to research and treatment must be taken. Even so, the hope is that bee venom may ... Bee venom is mostly water-88% to be exact. Because of this water solubility, bees sting in moist tissue in order for the venom ...
  • Bee venom is used to hyposensitize individuals highly sensitive to bee stings. (drugs.com)
  • Various adverse reactions may occur to bee venom, the severity of which depends on the number of stings sustained. (drugs.com)
  • Cautions: Do not use if you have an allergy to bee stings. (rodial.co.uk)
  • Venoms consist of toxic components that are delivered to their victims via bites or stings. (nih.gov)
  • These products are not as effective as bee stings, although they have the same structure. (tryhealthfitness.com)
  • Some patients may suffer from allergic reactions to bee stings. (tryhealthfitness.com)
  • Venom of honeybees is a clear liquid and treatment of bee stings with the venom of bees is called apitherapy (the venom is furthermore known as apitoxin). (guardianlv.com)
  • Persons with supposed allergies to bee stings or bee pollen should avoid all treatment options utilizing extracts or products from honeybees. (guardianlv.com)
  • Various cases describing corneal bee or wasp stings have been reported. (springeropen.com)
  • Melittin, a phospholipase activating protein in bee venom, has been shown to induce neutrophil degranulation 3 and to increase 3 or inhibit 4 the formation of superoxide. (drugs.com)
  • An extreme performance eye cream to smooth out under eye wrinkles, brighten dark circles and firm the skin with bee venom, stem cell technology and melittin peptide. (rodial.co.uk)
  • Dr. Graf says melittin, the active compound in bee venom, does have anti-bacterial and anti-inflammatory properties, and can boost the immune system. (allure.com)
  • Once applied, Bee venom (otherwise known as toxin melittin) tricks the skin, increasing blood circulation and also stimulating production of natural collagen and elastin, therefore resulting in a plumper, smoother appearance. (trademe.co.nz)
  • A) Percent IL-4eGFP+ T cells from popliteal LNs of 4get mice 5 days after subcutaneous immunization with PBS, bee venom, bvPLA2, or melittin. (nih.gov)
  • C) Serum OVA-specific IgE and IgG1 in BALB/c mice after subcutaneous immunization with OVA alone or in the presence of bee venom, bvPLA2, or melittin on day 0 and 21. (nih.gov)
  • Bee venom and its main constituent melittin (MEL) have been extensively studied in the treatment of tumors. (springermedizin.de)
  • In Japan, royal jelly has been used as a substance against the growth of malignant tumors. (tryhealthfitness.com)
  • In order to minimize allergic reactions, hyposensitization immunotherapy techniques have been developed in which small doses of the venom are administered under controlled conditions over a period of months to years. (drugs.com)
  • Patients allergic to honeybee venom may be particularly sensitive to hymenoptera venoms in general and have been found to be at a higher risk of developing systemic adverse reactions to venom immunotherapy than patients who are sensitive to yellow jacket venom. (drugs.com)
  • Venom immunotherapy (VIT) reduces the likelihood of systemic response in patients with systemic allergic reactions to insect venom. (drugs.com)
  • No animal data exist regarding the use of bee venom in immunotherapy. (drugs.com)
  • The infusion of beekeepers' plasma has been shown to protect patients against systemic reactions that can occur during active immunotherapy. (drugs.com)
  • in one study, this was accompanied by increases in the levels of anti-idiotypic antibodies and decreases in specific antibodies to honeybee venom (immunoglobulin G and E). The study was conducted over a 76-week period of immunotherapy with the venom. (drugs.com)
  • Background: Venom allergen immunotherapy (VIT) is proven to be highly effective for insect allergy, but the mechanisms and the biomarkers associated with clinical efficacy remain elusive. (elsevier.com)
  • The venom of Apis mellifera (honey bee) has been reported to play a role in immunotherapy, but existing evidence to support its immuno-modulatory claims is insufficient. (strath.ac.uk)
  • In 1992-1994 different bee venom collection methods were compared for the amount of venom collected and for their effect on the status of honey bee colonies and their wintering as well as on their general productivity (honey, pollen, beeswax). (eurekamag.com)
  • Bee pollen, on the other hand, is progressively utilized as a dietary supplement. (guardianlv.com)
  • Study is restricted and dangerous allergic reactions to bee pollen are likely. (guardianlv.com)
  • Combining real bee venom with aquaxyl and hyaluronic acid, the facial serum works to improve nutrient delivery between layers of skin, and increases blood circulation whilst firming and plumping to smooth out the visibility of lines and wrinkles. (iwantoneofthose.com)
  • This moisturiser combines real bee venom with manuka honey and hyaluronic acid to intensely nourish and hydrate the skin. (iwantoneofthose.com)
  • This rejuvenating eye serum combines real bee venom with hyaluronic acid to counteract dark circles and puffiness around the delicate eye area. (iwantoneofthose.com)
  • Tertiapin is a 21-residue peptide isolated from honey bee venoms. (aspetjournals.org)
  • In addition, wasp venom contains phospholipase A, phospholipase B, and mastoparan peptide, which can cause direct mast cell degranulation with the release of histamine. (springeropen.com)
  • Bee venom is a colorless liquid made up of proteins, enzymes, and soluble amino acids. (tryhealthfitness.com)
  • Housed in a vanity case, the set combines a trio of skincare products infused with the firming properties of bee venom to leave skin looking firmer, plumper and younger. (iwantoneofthose.com)
  • Honeybee venom is obtained from A. mellifera , the common honeybee. (drugs.com)
  • The allergic reactions are mediated by immunoglobulin E (IgE) antibodies directed at constituents of honeybee, yellow jacket, hornet, and wasp venoms. (drugs.com)
  • More recently, it has been suggested that honeybee venom may alleviate the symptoms and slow the progression of immune-modulated diseases such as arthritis and multiple sclerosis. (drugs.com)
  • Hypersensitivity to honeybee venom is mediated by a number of antibodies and immunomodulators, the most important of which appears to be IgE. (drugs.com)
  • These findings suggest that several mechanisms play an interrelated role in the development of immunity to honeybee venom. (drugs.com)
  • It has been speculated that honeybee venom may prevent the development of or improve the status of patients with rheumatoid arthritis. (drugs.com)
  • Antibacterial Activity and Antibiotic-Enhancing Effects of Honeybee Venom against Methicillin-Resistant Staphylococcus aureus. (sigmaaldrich.com)
  • It is one of the traditional folk remedies used, and there are many medicinal products containing bee venom, and these products are in the form of injections, or ointments can be obtained from pharmacies. (tryhealthfitness.com)
  • Bee venom phospholipase A2 induces a primary type 2 response that is dependent on the receptor ST2 and confers protective immunity. (nih.gov)
  • Here we examined how bee venom PLA2 is sensed by the innate immune system and induces a type 2 immune response in mice. (nih.gov)
  • Bee Venom: Plumps and smoothes fine lines and wrinkles. (rodial.co.uk)
  • Bee Venom is an active ingredient which works to diminish fine lines and wrinkles on the skin's surface. (trademe.co.nz)
  • As a part of the Rodial Bee Venum collection, this body soufflé is deeply moisturizing, with a whipped soufflé texture. (skinstore.com)
  • In addition to its known regulatory role in bone metabolism, osteopontin has been postulated to be a T H 1 cytokine and is involved in T H 1-associated immune responses. (drugs.com)
  • These data suggest that the innate immune system can detect the activity of a conserved component of venoms and induce a protective immune response against a venom toxin. (nih.gov)
  • Bee venom stimulates blood circulation to treated area to plump out the appearance of wrinkles under eyes which works in synergy with plant stem cells and haloxyl to help visibly improve skin tone and elasticity for a brighter appearance whilst cyclopeptide-5 smoothes the look of lines and wrinkles. (rodial.co.uk)
  • Pure New Zealand Bee Venom stimulates the production of collagen and elastin creating a tightening and smoothing effect, while Manuka Honey and Vitamins C and E improve skin texture and protect from everyday environmental pollution. (abeeco.com)
  • Zurück zum Zitat Al-Sadoon MK, Rabah DM, Badr G (2013) Enhanced anticancer efficacy of snake venom combined with silica nanoparticles in a murine model of human multiple myeloma: molecular targets for cell cycle arrest and apoptosis induction. (springermedizin.de)
  • Venom-collecting frames were inserted (1) in the lower hive body, or (2) in the upper hive body, or (3) in an empty body placed between the upper and lower bodies. (eurekamag.com)
  • We found that bee venom PLA2 induced a T helper type 2 (Th2) cell-type response and group 2 innate lymphoid cell activation via the enzymatic cleavage of membrane phospholipids and release of interleukin-33. (nih.gov)
  • Licorice root and its extracts have long been utilized to heal viral infection, stomach ulcers, and related throat issues. (guardianlv.com)
  • Based on a serendipitous obsrevation in one patient with Parkinson s disease (PD), resaerchers wish to verify, in a pre-clinical model of the disease, whether bee venom and one of its components, apamine, are able to stop or slow the loss of dopaminergic neurons. (michaeljfox.org)
  • In parallel, these models will be treated with bee venom or one of its components called apamine. (michaeljfox.org)
  • Researchers verified, in a pre-clinical model of the disease, that bee venom and one of its components, apamine, are able to stop or slow the loss of dopaminergic neurons, the neuronal cell type most severely affected in PD. (michaeljfox.org)
  • Produced as a pure substance in the form of a substance, and in the form of many preparations based on bee venom formegel, balm and ointment, which include various components that enhance the pharmacological effect of drugs. (medsides.com)
  • They lose some components of bee venom, which has a healing effect. (tryhealthfitness.com)
  • Bee venom injections are used for desesentization treatments against allergies to bee venom. (michaeljfox.org)
  • This study would pave the way for a first clinical trial, which would be fairly easy to organize since bee venom injections are considered to be safe and simple. (michaeljfox.org)
  • They showed that regular bee venom injections are indeed able to slow the degeneration of dopaminergic neurons in the PD model used, and that this effect is partially due to apamine. (michaeljfox.org)
  • This product contains 90% snail extract and bee venom instead of water. (korendy.com)
  • Contraindications have not been identified. (drugs.com)
  • A-E) CD4+ GFP+ T cells from popliteal LNs of 4get mice 5 days after subcutaneous immunization with (A) active bvPLA2 or heat-inactivated bvPLA2 (C) OVA in the presence of LPC or AA (D) OVA, Crotalus atrox venom or Agkistrodon contortrix venom (E) OVA, Crotalus adamanteus venom, or Crotalus adamanteus PLA2. (nih.gov)
  • Especially often used bee venom for joints with arthritis, arthrosis, radiculitis. (medsides.com)
  • The Bee Venom is used to fool the skin into thinking it has been lightly stung. (abeeco.com)
  • Phospholipase A2 (PLA2) is a conserved component of venoms from multiple species and is the major allergen in bee venom. (nih.gov)
  • Some people suffer from the sensitivity of bee venom, and get them many reactions that can occur from bee bites or from the product extracted from bee venom, but usually a local reaction with redness and tumor affects the location of the sting, and some suffer from a stronger reaction This occurs when the tumor increases and spreads throughout the limb and causes movement problems. (tryhealthfitness.com)
  • Clinical course and prognosis ranged from mild to severe damage depending on the type of bee or wasp, depth of injury, and toxic or immunological response to the venom injected by the stinger. (springeropen.com)
  • There is no recent clinical evidence to guide dosage of bee venom. (drugs.com)
  • Everybody wants to be the next Botox,' says Dr. Graf, 'but there haven't been enough clinical trials to judge the effect of the venom. (allure.com)
  • Unlike numerous of the other herbs and supplements utilized to heal MS and its symptoms, bee venom has been expressly studied for its effects on MS in several clinical tests. (guardianlv.com)
  • Poisoning, or the substance left by the bee when a person bites, is composed of hydrochloric acid, acetic acid, phosphorus acid, histamine, piamin, methionine, bovine, cysteine and bee marking with an acid reaction due to the abundance of acids in its composition. (tryhealthfitness.com)
  • Treatment with bee venom is widely used for various diseases of the musculoskeletal system. (medsides.com)
  • In this review, we summarize the current knowledge regarding anticancer effects of bee venom and its main compound MEL on different kinds of tumor cells as well as elucidate their possible anticancer mechanisms. (springermedizin.de)
  • It is also known that bee sting treatment can cause pain, as well as some side effects such as anxiety , dizziness, insomnia, changes in blood pressure, and palpitations of the heart. (tryhealthfitness.com)
  • Experience the ultimate in anti-ageing with skinChemists Bee Venom Treatment Set . (iwantoneofthose.com)
  • Methods of using bee sting treatment. (tryhealthfitness.com)
  • Other ones show that bee venom treatment is ineffective, insufficiently studied, or downright unsafe. (guardianlv.com)
  • Since the venom is anaphylactic, it temporarily relaxes the facial muscles, breaking down cell membranes and improving circulation-all of which can theoretically contribute to a tighter complexion. (allure.com)