Beclomethasone: An anti-inflammatory, synthetic glucocorticoid. It is used topically as an anti-inflammatory agent and in aerosol form for the treatment of ASTHMA.Anti-Asthmatic Agents: Drugs that are used to treat asthma.Administration, Inhalation: The administration of drugs by the respiratory route. It includes insufflation into the respiratory tract.Aerosol Propellants: Compressed gases or vapors in a container which, upon release of pressure and expansion through a valve, carry another substance from the container. They are used for cosmetics, household cleaners, and so on. Examples are BUTANES; CARBON DIOXIDE; FLUOROCARBONS; NITROGEN; and PROPANE. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Nebulizers and Vaporizers: Devices that cause a liquid or solid to be converted into an aerosol (spray) or a vapor. It is used in drug administration by inhalation, humidification of ambient air, and in certain analytical instruments.Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).Aerosols: Colloids with a gaseous dispersing phase and either liquid (fog) or solid (smoke) dispersed phase; used in fumigation or in inhalation therapy; may contain propellant agents.Anti-Inflammatory Agents: Substances that reduce or suppress INFLAMMATION.Pregnenediones: Unsaturated pregnane derivatives containing two keto groups on side chains or ring structures.Budesonide: A glucocorticoid used in the management of ASTHMA, the treatment of various skin disorders, and allergic RHINITIS.Glucocorticoids: A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.Metered Dose Inhalers: A small aerosol canister used to release a calibrated amount of medication for inhalation.Peak Expiratory Flow Rate: Measurement of the maximum rate of airflow attained during a FORCED VITAL CAPACITY determination. Common abbreviations are PEFR and PFR.Albuterol: A short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared as a racemic mixture of R(-) and S(+) stereoisomers. The stereospecific preparation of R(-) isomer of albuterol is referred to as levalbuterol.Chlorofluorocarbons: A series of hydrocarbons containing both chlorine and fluorine. These have been used as refrigerants, blowing agents, cleaning fluids, solvents, and as fire extinguishing agents. They have been shown to cause stratospheric ozone depletion and have been banned for many uses.Double-Blind Method: A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.Administration, Topical: The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.Hydrocarbons, FluorinatedBronchodilator Agents: Agents that cause an increase in the expansion of a bronchus or bronchial tubes.Androstadienes: Derivatives of the steroid androstane having two double bonds at any site in any of the rings.Powders: Substances made up of an aggregation of small particles, as that obtained by grinding or trituration of a solid drug. In pharmacy it is a form in which substances are administered. (From Dorland, 28th ed)Pituitary-Adrenal Function Tests: Tests that evaluate the adrenal glands controlled by pituitary hormones.Hydrocortisone: The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.Forced Expiratory Volume: Measure of the maximum amount of air that can be expelled in a given number of seconds during a FORCED VITAL CAPACITY determination . It is usually given as FEV followed by a subscript indicating the number of seconds over which the measurement is made, although it is sometimes given as a percentage of forced vital capacity.Adrenal Cortex HormonesEye Manifestations: Ocular disorders attendant upon non-ocular disease or injury.Asthenia: Clinical sign or symptom manifested as debility, or lack or loss of strength and energy.Ethanolamines: AMINO ALCOHOLS containing the ETHANOLAMINE; (-NH2CH2CHOH) group and its derivatives.Pregnanetriol: A metabolite of 17-ALPHA-HYDROXYPROGESTERONE, normally produced in small quantities by the GONADS and the ADRENAL GLANDS, found in URINE. An elevated urinary pregnanetriol is associated with CONGENITAL ADRENAL HYPERPLASIA with a deficiency of STEROID 21-HYDROXYLASE.Fluocinolone Acetonide: A glucocorticoid derivative used topically in the treatment of various skin disorders. It is usually employed as a cream, gel, lotion, or ointment. It has also been used topically in the treatment of inflammatory eye, ear, and nose disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p732)Bronchial Provocation Tests: Tests involving inhalation of allergens (nebulized or in dust form), nebulized pharmacologically active solutions (e.g., histamine, methacholine), or control solutions, followed by assessment of respiratory function. These tests are used in the diagnosis of asthma.Rhinitis, Allergic, Seasonal: Allergic rhinitis that occurs at the same time every year. It is characterized by acute CONJUNCTIVITIS with lacrimation and ITCHING, and regarded as an allergic condition triggered by specific ALLERGENS.Adrenal Cortex Function Tests: Examinations that evaluate and monitor hormone production in the adrenal cortex.Administration, Oral: The giving of drugs, chemicals, or other substances by mouth.Respiratory Therapy: Care of patients with deficiencies and abnormalities associated with the cardiopulmonary system. It includes the therapeutic use of medical gases and their administrative apparatus, environmental control systems, humidification, aerosols, ventilatory support, bronchopulmonary drainage and exercise, respiratory rehabilitation, assistance with cardiopulmonary resuscitation, and maintenance of natural, artificial, and mechanical airways.Pregnadienediols: Doubly unsaturated pregnane derivatives with two hydroxy groups substituted anywhere on the rings or side chains.Adrenergic beta-Agonists: Drugs that selectively bind to and activate beta-adrenergic receptors.Clinical Trials as Topic: Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.Prednisolone: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.Cosyntropin: A synthetic peptide that is identical to the 24-amino acid segment at the N-terminal of ADRENOCORTICOTROPIC HORMONE. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of CORTICOSTEROIDS in the ADRENAL CORTEX.Cross-Over Studies: Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)Methylprednisolone: A PREDNISOLONE derivative with similar anti-inflammatory action.Placebos: Any dummy medication or treatment. Although placebos originally were medicinal preparations having no specific pharmacological activity against a targeted condition, the concept has been extended to include treatments or procedures, especially those administered to control groups in clinical trials in order to provide baseline measurements for the experimental protocol.Respiratory Function Tests: Measurement of the various processes involved in the act of respiration: inspiration, expiration, oxygen and carbon dioxide exchange, lung volume and compliance, etc.Drug Administration Schedule: Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.Pituitary-Adrenal System: The interactions between the anterior pituitary and adrenal glands, in which corticotropin (ACTH) stimulates the adrenal cortex and adrenal cortical hormones suppress the production of corticotropin by the anterior pituitary.Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.Nasal Mucosa: The mucous lining of the NASAL CAVITY, including lining of the nostril (vestibule) and the OLFACTORY MUCOSA. Nasal mucosa consists of ciliated cells, GOBLET CELLS, brush cells, small granule cells, basal cells (STEM CELLS) and glands containing both mucous and serous cells.Protective Devices: Devices designed to provide personal protection against injury to individuals exposed to hazards in industry, sports, aviation, or daily activities.Nasal Sprays: Pharmacologic agents delivered into the nostrils in the form of a mist or spray.Administration, Intranasal: Delivery of medications through the nasal mucosa.Drug Approval: Process that is gone through in order for a drug to receive approval by a government regulatory agency. This includes any required pre-clinical or clinical testing, review, submission, and evaluation of the applications and test results, and post-marketing surveillance of the drug.United States Food and Drug Administration: An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.Postpoliomyelitis Syndrome: A syndrome characterized by new neuromuscular symptoms that occur at least 15 years after clinical stability has been attained in patients with a prior history of symptomatic poliomyelitis. Clinical features include new muscular weakness and atrophy of the limbs, bulbar innervated musculature, and muscles of respiration, combined with excessive fatigue, joint pain, and reduced stamina. The process is marked by slow progression and periods of stabilization. (From Ann NY Acad Sci 1995 May 25;753:68-80)Dry Powder Inhalers: A device that delivers medication to the lungs in the form of a dry powder.Drug Information Services: Services providing pharmaceutic and therapeutic drug information and consultation.Medical Assistance: Financing of medical care provided to public assistance recipients.Uncompensated Care: Medical services for which no payment is received. Uncompensated care includes charity care and bad debts.Pharmacies: Facilities for the preparation and dispensing of drugs.Point-of-Care Systems: Laboratory and other services provided to patients at the bedside. These include diagnostic and laboratory testing using automated information entry.Software: Sequential operating programs and data which instruct the functioning of a digital computer.User-Computer Interface: The portion of an interactive computer program that issues messages to and receives commands from a user.Computer Graphics: The process of pictorial communication, between human and computers, in which the computer input and output have the form of charts, drawings, or other appropriate pictorial representation.Algorithms: A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.Cromolyn Sodium: A chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells. It is used in the prophylactic treatment of both allergic and exercise-induced asthma, but does not affect an established asthmatic attack.Drug Interactions: The action of a drug that may affect the activity, metabolism, or toxicity of another drug.Adrenal Insufficiency: Conditions in which the production of adrenal CORTICOSTEROIDS falls below the requirement of the body. Adrenal insufficiency can be caused by defects in the ADRENAL GLANDS, the PITUITARY GLAND, or the HYPOTHALAMUS.Investigational New Drug Application: An application that must be submitted to a regulatory agency (the FDA in the United States) before a drug can be studied in humans. This application includes results of previous experiments; how, where, and by whom the new studies will be conducted; the chemical structure of the compound; how it is thought to work in the body; any toxic effects found in animal studies; and how the compound is manufactured. (From the "New Medicines in Development" Series produced by the Pharmaceutical Manufacturers Association and published irregularly.)Drug-Related Side Effects and Adverse Reactions: Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chemically-induced adverse conditions due to toxicity, DRUG INTERACTIONS, and metabolic effects of pharmaceuticals.Functional Residual Capacity: The volume of air remaining in the LUNGS at the end of a normal, quiet expiration. It is the sum of the RESIDUAL VOLUME and the EXPIRATORY RESERVE VOLUME. Common abbreviation is FRC.Total Lung Capacity: The volume of air contained in the lungs at the end of a maximal inspiration. It is the equivalent to each of the following sums: VITAL CAPACITY plus RESIDUAL VOLUME; INSPIRATORY CAPACITY plus FUNCTIONAL RESIDUAL CAPACITY; TIDAL VOLUME plus INSPIRATORY RESERVE VOLUME plus functional residual capacity; or tidal volume plus inspiratory reserve volume plus EXPIRATORY RESERVE VOLUME plus residual volume.Ambroxol: A metabolite of BROMHEXINE that stimulates mucociliary action and clears the air passages in the respiratory tract. It is usually administered as the hydrochloride.Lung Volume Measurements: Measurement of the amount of air that the lungs may contain at various points in the respiratory cycle.Clotrimazole: An imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal CELL MEMBRANES. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane.Imidazoles: Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. Chemically reduced ones include IMIDAZOLINES and IMIDAZOLIDINES. Distinguish from 1,2-diazole (PYRAZOLES).Miconazole: An imidazole antifungal agent that is used topically and by intravenous infusion.Neomycin: Antibiotic complex produced by Streptomyces fradiae. It is composed of neomycins A, B, and C. It acts by inhibiting translation during protein synthesis.Burning Mouth Syndrome: A group of painful oral symptoms associated with a burning or similar sensation. There is usually a significant organic component with a degree of functional overlay; it is not limited to the psychophysiologic group of disorders.Pruritus Vulvae: Intense itching of the external female genitals.Postural Orthostatic Tachycardia Syndrome: A syndrome of ORTHOSTATIC INTOLERANCE combined with excessive upright TACHYCARDIA, and usually without associated ORTHOSTATIC HYPOTENSION. All variants have in common an excessively reduced venous return to the heart (central HYPOVOLEMIA) while upright.Adenoids: A collection of lymphoid nodules on the posterior wall and roof of the NASOPHARYNX.Libraries, MedicalNasal Decongestants: Drugs designed to treat inflammation of the nasal passages, generally the result of an infection (more often than not the common cold) or an allergy related condition, e.g., hay fever. The inflammation involves swelling of the mucous membrane that lines the nasal passages and results in inordinate mucus production. The primary class of nasal decongestants are vasoconstrictor agents. (From PharmAssist, The Family Guide to Health and Medicine, 1993)Hypertrophy: General increase in bulk of a part or organ due to CELL ENLARGEMENT and accumulation of FLUIDS AND SECRETIONS, not due to tumor formation, nor to an increase in the number of cells (HYPERPLASIA).

A comparative study of the effects of ketotifen, disodium cromoglycate, and beclomethasone dipropionate on bronchial mucosa and asthma symptoms in patients with atopic asthma. (1/348)

Asthma is a chronic inflammatory disorder of the airways that is characterized by infiltration of many inflammatory cells into the bronchial mucosa. We compared the effects of ketotifen, disodium cromoglycate (DSCG), and beclomethasone dipropionate (BDP) on inflammatory cells in the bronchial mucosa and on the asthma symptoms of patients with atopic asthma. In this 12-week parallel study, 32 patients were randomly allocated to either the ketotifen group (2 mg day-1, n = 13), DSCG group (8 mg day-1, n = 9) or BDP (400 micrograms day-1, n = 10). Each subject recorded daily asthma symptoms and peak expiratory flow (PEF). Before and after treatment, pulmonary function and bronchial responsiveness to methacholine were evaluated, and fibreoptic bronchoscopy and biopsy were performed before and after treatment. Biopsy specimens were obtained by bronchoscopy. We performed immunohistochemistry using specific monoclonal antibodies for activated eosinophils (EG2), mast cells (AA1), and T cells (CD3, CD4, and CD8). Our clinical findings showed significant improvement in symptom score and bronchial responsiveness (P < 0.01) each) in all groups. Both the DSCG and the BDP groups had significantly better symptom scores than the ketotifen group (P < 0.05, both groups). PEF significantly increased in the DSCG group in comparison to the ketotifen (P < 0.01) and BDP (P < 0.05) groups, FEV1% increased significantly in the DSCG (P < 0.01) and BDP (P < 0.05) groups in comparison to the ketotifen group. Compared with their baseline values, treatment significantly decreased EG2+ activated eosinophils, and CD3+ and CD4+ T cells, in each group (P < 0.01). Both the DSCG (P < 0.05) and the BDP groups (P < 0.01) exhibited significant decreases in AA1+ mast cell count, but this was not observed in the ketotifen group. Comparing before- and after-treatment values, only the DSCG group exhibited a significant decrease in the number of CD8+ T cells (P < 0.01). Ketotifen, DSCG, and BDP all showed anti-inflammatory activity as determined by examination of the bronchial mucosa of asthmatic patients; and both the DSCG and BDP groups had better clinical responses than the ketotifen group.  (+info)

Vascularity in asthmatic airways: relation to inhaled steroid dose. (2/348)

BACKGROUND: There is an increase in vascularity in the asthmatic airway. Although inhaled corticosteroids (ICS) are an effective anti-inflammatory treatment in asthma, there are few data on any effects on structural changes. METHODS: Endobronchial biopsy specimens from seven asthmatic subjects not receiving ICS and 15 receiving 200-1500 microg/day beclomethasone dipropionate (BDP) were immunohistochemically stained with an anti-collagen type IV antibody to outline the endothelial basement membrane of the vessels. These were compared with biopsy tissue from 11 non-asthmatic controls (four atopic and seven non-atopic). RESULTS: There was a significant increase in the density of vessels (number of vessels/mm2 of lamina propria) in the asthmatic subjects not on ICS compared with non-asthmatic controls (mean 485 (interquartile range (IQR) 390-597) versus 329 (IQR 248-376) vessels/mm2, p<0.05; 95% CI for the difference 48 to 286). There was no significant difference between asthmatic subjects on ICS and those not on ICS or control subjects in the number of vessels/mm2 (mean 421 (IQR 281-534)). However, patients who received >/=800 microg/day BDP tended to have a reduced number of vessels/mm2 compared with patients not on ICS and those receiving +info)

Early inhaled glucocorticoid therapy to prevent bronchopulmonary dysplasia. (3/348)

BACKGROUND: The safety and efficacy of inhaled glucocorticoid therapy for asthma stimulated its use in infants to prevent bronchopulmonary dysplasia. We tested the hypothesis that early therapy with inhaled glucocorticoids would decrease the frequency of bronchopulmonary dysplasia in premature infants. METHODS: We conducted a randomized, multicenter trial of inhaled beclomethasone or placebo in 253 infants, 3 to 14 days old, born before 33 weeks of gestation and weighing 1250 g or less at birth, who required ventilation therapy. Beclomethasone was delivered in a decreasing dosage, from 40 to 5 microg per kilogram of body weight per day, for four weeks. The primary outcome measure was bronchopulmonary dysplasia at 28 days of age. Secondary outcomes included bronchopulmonary dysplasia at 36 weeks of postmenstrual age, the need for systemic glucocorticoid therapy, the need for bronchodilator therapy, the duration of respiratory support, and death. RESULTS: One hundred twenty-three infants received beclomethasone, and 130 received placebo. The frequency of bronchopulmonary dysplasia was similar in the two groups: 43 percent in the beclomethasone group and 45 percent in the placebo group at 28 days of age, and 18 percent in the beclomethasone group and 20 percent in the placebo group at 36 weeks of postmenstrual age. At 28 days of age, fewer infants in the beclomethasone group than in the placebo group were receiving systemic glucocorticoid therapy (relative risk, 0.6; 95 percent confidence interval, 0.4 to 1.0) and mechanical ventilation (relative risk, 0.8; 95 percent confidence interval, 0.6 to 1.0). CONCLUSIONS: Early beclomethasone therapy did not prevent bronchopulmonary dysplasia but was associated with lower rates of use of systemic glucocorticoid therapy and mechanical ventilation.  (+info)

Asthma treatment costs using inhaled corticosteroids. (4/348)

Asthma is a chronic inflammatory disorder of the airways that affects 10 to 17.5 million people and leads to more than $5 billion in treatment costs in the Unites States annually. This retrospective study is an initial step in understanding the beneficial economic outcomes of inhaled corticosteroid therapy by determining whether differences exist in healthcare utilization expenditures for three inhaled corticosteroids available for use in the United States: (1) beclomethasone dipropionate (Vanceril/Schering and Beclovent/Allan & Hanburys); (2) flunisolide (Aerobid/Forest); and (3) and triamcinolone acetonide (Azmacort/Rhone-Poulenc Rorer). This study was based on an analysis of 4,441 patients with at least one pharmaceutical claim for one of the study drugs, using inpatient, outpatient, and prescription drug claims data obtained from The MEDSTAT Group's MarketScan database for calendar years 1990 through 1993. We tested a null hypothesis for no differences in total asthma treatment costs, when drugs were excluded, using multivariate linear regression modeling controlling for patient demographic and clinical characteristics that might affect the study outcome. We found that, after excluding study drug payments and controlling for other contributing factors, total asthma healthcare expenditures to triamcinolone acetonide (Azmacort) users were higher than those for beclomethasone dipropionate (Vanceril and Beclovent) and flunisolide (Aerobid) users. When study drug costs were included in the expenditure measure, both triamcinolone acetonide (Azmacort) and flunisolide (Aerobid) users had higher expenditures than did beclomethasone dipropionate (Vanceril and Beclovent) users. No significant differences in expenditures were detected between Vanceril and Beclovent patients, a finding consistent with the fact that these drugs are the same type of inhaled corticosteroid. Other factors contributing to differences in total asthma healthcare costs included patient age, patterns of switching among and continuing with study drugs, prestudy asthma utilization or drug proxy severity, and comorbidities of precipitating illnesses.  (+info)

Systemic activity of inhaled and swallowed beclomethasone dipropionate and the effect of different inhaler devices. (5/348)

Inhaled glucocorticoids such as beclomethasone dipropionate, which are used in the treatment of asthma, may be associated with systemic adverse effects. To determine whether any systemic absorption following the inhalation of beclomethasone was a result of drug being absorbed from the lung (inhaled fraction) or the gastrointestinal tract (swallowed fraction), we studied normal subjects after the inhalation or swallowing of 2 mg beclomethasone dipropionate. Systemic activity was assessed using early morning cortisol suppression. Both inhaled and swallowed fractions produced significant systemic activity, the degree of which depended on the inhaler device used. Systemic activity was greater using a dry powder inhaler (52%) than using a metered dose inhaler with a large volume spacer (28%). These findings suggest that to limit potential adverse effects from high-dose beclomethasone dipropionate it is better to use a metered dose aerosol with large volume spacer than a dry powder.  (+info)

A comparative analysis of the particle size output of beclomethasone diproprionate, salmeterol xinafoate and fluticasone propionate metered dose inhalers used with the Babyhaler, Volumatic and Aerochamber spacer devices. (6/348)

AIMS: To determine in vitro the effect of delay, inspiratory flow, and spacer washing on the drug output of metered dose inhalers (MDIs) used with different spacer devices. METHODS: The amount of drug in particles <5 microm diameter from MDI+spacer, sampling after a delay of up to 20 s, was measured using a Multistage Liquid Impinger. Drug output was also measured at different flow rates, and after washing the Babyhaler in household detergent. RESULTS: More fluticasone in small particles was recovered from the Babyhaler than the Volumatic or the Aerochamber spacers, and more beclomethasone and salmeterol was recovered from the Babyhaler and Volumatic spacers than from the Aerochamber. Washing the Babyhaler reduced the recovery of salmeterol, and did not alter the recovery of the other drugs tested. CONCLUSIONS: Spacer devices need to be fully evaluated for each drug prescribed for them.  (+info)

Long term effects of inhaled corticosteroids in chronic obstructive pulmonary disease: a meta-analysis. (7/348)

BACKGROUND: The role of inhaled corticosteroids in the long term management of chronic obstructive pulmonary disease (COPD) is still unclear. A meta-analysis of the original data sets of the randomised controlled trials published thus far was therefore performed. The main question was: "Are inhaled corticosteroids able to slow down the decline in lung function (FEV1) in COPD?" METHODS: A Medline search of papers published between 1983 and 1996 was performed and three studies were selected, two of which were published in full and one in abstract form. Patients with "asthmatic features" were excluded from the original data. Ninety five of the original 140 patients treated with inhaled corticosteroids (81 with 1500 micrograms beclomethasone daily, six with 1600 micrograms budesonide daily, and eight with 800 micrograms beclomethasone daily) and 88 patients treated with placebo (of the initial 144 patients) were included in the analysis. The effect on FEV1 was assessed by a multiple repeated measurement technique in which points of time in the study and treatment effects (inhaled corticosteroids compared with placebo) were investigated. RESULTS: No baseline differences were observed (mean age 61 years, mean FEV1 45% predicted). The estimated two year difference in prebronchodilator FEV1 was +0.034 l/year (95% confidence interval (CI) 0.005 to 0.063) in the inhaled corticosteroid group compared with placebo. The postbronchodilator FEV1 showed a difference of +0.039 l/year (95% CI -0.006 to 0.084). No beneficial effect was observed on the exacerbation rate. Worsening of the disease was the reason for drop out in four patients in the treatment group compared with nine in the placebo group. In the treatment group six of the 95 subjects dropped out because of an adverse effect which may have been related to the treatment compared with two of the 88 patients in the placebo group. CONCLUSIONS: This meta-analysis in patients with clearly defined moderately severe COPD showed a beneficial course of FEV1 during two years of treatment with relatively high daily dosages of inhaled corticosteroids.  (+info)

Skin bruising, adrenal function and markers of bone metabolism in asthmatics using inhaled beclomethasone and fluticasone. (8/348)

Fluticasone propionate (FP) is generally considered to have twice the efficacy of beclomethasone dipropionate (BDP) on a weight-to-weight basis for the control of asthma, and may have lesser effects on adrenal function. However, the effects of FP and BDP on skin integrity and bone metabolism markers require further examination. Sixty-nine asthmatic subjects were enrolled in a double-blind crossover study in which, after a baseline period, they received BDP or FP (at half the dose of BDP) for two 4-month periods each. A questionnaire on skin bruising, a skin examination, tests of adrenal function and of markers of bone metabolism were performed after 2 months of each period. The number of asthma exacerbations was not significantly different for the two treatment periods (eight for BDP and nine for FP), nor were various indices of asthma control. Whereas the frequency of bruising reported by the questionnaire was not different, there were more bruises on examination for BDP (1.6+/-2.5) than for FP (1.2+/-2.3) (p=0.04). Although baseline serum cortisol was not significantly different for the two drugs, the increase in cortisol after cortrosyn was lower for BDP (357+/-158 micromol x dL(-1)) than for FP (422+/-144 micromol x dL(-1)) (p<0.01). Serum osteocalcin levels were significantly lower in subject on BDP (2.8+/-1.7 microg x mL(-1)) than on FP (3.5+/-1.9 ng x mL(-1)) (p=0.003). Other markers of bone metabolism were not significantly altered. The three major side-effects were loosely, but significantly correlated with the periods on BDP and FP. However, skin bruises, increase in cortisol after Cortrosyn and osteocalcin were not significantly correlated for the period on either BDP or FP. In conclusion, whereas fluticasone propionate used at half the dose of beclomethasone dipropionate has a comparable effect on the control of asthma, fluticasone propionate demonstrated fewer side-effects in terms of skin bruising, adrenal suppression and bone metabolism.  (+info)

*Beclometasone dipropionate

"Beclomethasone Dipropionate eent". The American Society of Health-System Pharmacists. Archived from the original on 2015-12-08 ... "Beclomethasone Dipropionate". The American Society of Health-System Pharmacists. Archived from the original on 2015-12-08. ... Beclometasone dipropionate is the INN modified and beclomethasone dipropionate is the USAN and former BAN. It is a prodrug of ... Willey R, Milne L, Crompton G, Grant I (1976). "Beclomethasone dipropionate aerosol and oropharyngeal candidiasis". Br J Dis ...

*Corticosteroid

This group includes: Flunisolide Fluticasone furoate Fluticasone propionate Triamcinolone acetonide Beclomethasone dipropionate ... Comparison of fluticasone and beclomethasone". Annals of Allergy, Asthma & Immunology. 90 (6): 646-651. doi:10.1016/S1081-1206( ...

*Forskolin

Huerta M, Urzúa Z, Trujillo X, González-Sánchez R, Trujillo-Hernández B (2010). "Forskolin compared with beclomethasone for ...

*Steroid dementia syndrome

The medications included prednisone, and methylprednisolone, plus albuterol, beclomethasone, dexamethasone, cromolyn, ...

*Recurrent airway obstruction

Originally, beclomethasone was used, but newer compounds are available now, such as fluticasone propionate. 3) Mast cell ...

*Beclometasone

... (brand names Becotide, Beclocort), or beclomethasone, is a synthetic glucocorticoid corticosteroid which is ...

*Asthma

Inhaled forms such as beclomethasone are usually used except in the case of severe persistent disease, in which oral ...

*Metered-dose inhaler

For one variety of beclomethasone inhaler, this redesign resulted in considerably smaller aerosol particles being produced, and ...

*List of corticosteroid esters

... beclomethasone dipropionate) Beclometasone salicylate Beclometasone valeroacetate Betamethasone acetate Betamethasone acibutate ...

*List of GlaxoSmithKline products

... beclomethasone dipropionate) Benlysta (belimumab) Betnovate (betamethasone valerate) Bexxar (tositumomab) Breo (fluticasone ...

*Decongestant

Tymazoline Beclomethasone dipropionate (Beconase, QNASL) Budesonide (Rhinocort) Ciclesonide (Omnaris, Zetonna) Dexamethasone ...

*Graceway Pharmaceuticals

Norgesic Forte algesic and skeletal muscle relaxant orphenadrine Qvar corticosteroid inhaler beclomethasone Tambocor ...

*Scottish inventions and discoveries

Developing modern asthma therapy based both on bronchodilation (salbutamol) and anti-inflammatory steroids (beclomethasone ...

*Nasal spray

Beclomethasone dipropionate Budesonide Ciclesonide Flunisolide Fluticasone furoate Fluticasone propionate Mometasone ...

*Annexin A1

Glucocorticoids (such as budesonide, cortisol, and beclomethasone) are a class of endogenous or synthetic anti-inflammatory ...

*List of medical inhalants

Nitric oxide Beclomethasone Budesonide Ciclesonide Cromolyn Dexamethasone Flunisolide Fluticasone Mometasone Nedocromil ...

*Index of oncology articles

... beclomethasone - Bellini duct carcinoma - bendamustine - benign - benign proliferative breast disease - benign prostatic ...

*Respiratory Pharmacology

Beractant Calfactant Poractant alfa Beclomethasone (dipropionate) Triamcinolone acetonide Flunisolide (hemihydrate) Fluticasone ...

*List of MeSH codes (D04)

... beclomethasone MeSH D04.808.745.432.769.199 --- betamethasone MeSH D04.808.745.432.769.199.150 --- betamethasone 17-valerate ... beclomethasone MeSH D04.808.883.294 --- chlormadinone acetate MeSH D04.808.883.419 --- cyproterone MeSH D04.808.883.419.150 ...
Eighteen children suffering from hay fever were treated with intra-nasal beclomethasone dipropionate (400 mug/day) and an identical placebo aerosol in a double-blind cross-over trial. 17 of the children preferred the intranasal beclomethasone dipropionate, one had no preference, none preferred the placebo. The effect on the nasal symptoms was impressive. Symptom scores decreased, on average, to 12% and the number of antihistamine tablets taken to 18% of the pretreatment amount. Some beneficial effect on eye symptoms was also discernible, possibly due to an indirect influence from the nasal mucosa via the nasolacrimal reflex. Adrenal function was not affected. It was concluded that 400 mug beclomethasone dipropionate given intranasally daily for some weeks is an effective and safe treatment for hay fever in children.. ...
Twenty-five patients with severe childhood asthma were treated with beclomethasone dipropionate. 21 of these children were receiving oral corticosteroid therapy in addition to disodium cromoglycate.. Of the total treated, 21 children improved or maintained their asthma status on this treatment over an average period of 4 months, and were able to reduce and stop their regular oral corticosteroid dosage, but 4 children had to revert to their original therapy.. No systemic or local toxic effects were experienced by any of the children.. Beclomethasone dipropionate appears to be an effective drug in the treatment of severe childhood asthma in those patients who need corticosteroid therapy in addition to disodium cromoglycate.. ...
Patient selection. Patients who develop symptoms of GVHD are evaluated with endoscopy and mucosal biopsy. If biopsy specimens demonstrate histologic findings of GVHD and stool and mucosal biopsy cultures are negative for pathogens, patients are invited to participate. Patients are excluded if diarrhea exceeds one liter per day, or if skin or liver GVHD are present. All patients receive medications for GVHD prophylaxis; patients receiving corticosteroids within 30 days of study entry are excluded. Patients signed informed consent documents approved by Institutional Review Boards.. Formulation of BDP. Immediate release tablets and enteric-coated tablets, each contained 1 mg of BDP (orBec, DOR BioPharma, Miami FL). The dosing regimen was one immediate release and one enteric-coated tablet, taken orally four times daily (total daily dose, 8 mg BDP).. Stratification and randomization. A stratified allocation scheme is used to balance the treatment groups within study centers. Stratifying variables ...
Beclometasone dipropionate, tseem spelled beclomethasone dipropionate thiab muag nyob rau hauv lub npe Qvar ntawm lwm tus neeg, yog tshuaj noj steroid.Nws yog muaj raws li lub tshuaj nqus, tshuaj nplaum, tshuaj, thiab qhov ntswg tsuag. Hauv daim ntawv nqus yog siv hauv kev tswj xyuas ntev ntawm kev mob ntsws .Kom qab zib siv tau rau dermatitis thiab psoriasis.Qhov tshuaj tau siv los kho ulcerative colitis.The lub qhov ntswg tshuaj siv los kho cov allergic rhinitis thiab cov nas ntswg.
First and Only Breath-Actuated Aerosol Inhaled Corticosteroid in the United States Designed to Help Eliminate the Need for Hand-Breath Coo, Teva Announces U.S. Launch of QVAR® RediHaler™ (Beclomethasone Dipropionate HFA) Inhalation Aerosol
Maintenance Treatment Option Designed to Eliminate the Need for Hand-Breath Coordination During Inhalation JERUSALEM--(BUSINESS WIRE)-, Teva Announces FDA Approval of QVAR® RediHaler™ (Beclomethasone Dipropionate HFA) Inhalation Aerosol
Medicines containing beclomethasone dipropionate, including Beclometasone HFA Autohaler, Easyhaler, Cyclocaps; their forms, doses and companies.
OBJECTIVE We examined the therapeutic strategies for treating mild gastrointestinal (GI) graft-versus-host disease (GVHD) using oral beclomethasone dipropionate (BDP) in 15 Japanese patients based on the donor source. The primary objective was to determine the efficacy and toxicity of oral BDP combined with/without low-dose prednisone (PSL). METHODS Oral BDP was administered with 1 mg/kg/d of PSL in patients undergoing bone marrow transplantation (BMT) or peripheral blood stem cell transplantation (PBSCT; n=11), and the dose of PSL was tapered off after 22 days. Oral BDP alone was administered in patients undergoing cord blood stem cell transplantation (CBSCT; n=4). The primary endpoint was the rate of treatment success on day 49, as measured according to the improvement or complete resolution of GI symptoms without additional treatment. The secondary endpoints included treatment-related toxicity according to the National Cancer Institute Common Toxicity Criteria version 3.0, the rate of treatment
Medicines containing beclomethasone dipropionate, including Alveobec Inhaler, Andion, Anceron, Apo-Beclomethasone; their forms, doses and companies.
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Preferred Name: Beclomethasone Dipropionate Definition: The dipropionate ester of a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. After cell surface receptor attachment and cell entry, beclomethasone enters the nucleus where it binds to and activates specific nuclear receptors, resulting in an altered gene expression and inhibition of proinflammatory cytokine production. Display Name: Beclomethasone Dipropionate Label: Beclomethasone Dipropionate NCI Thesaurus Code: C299 (Search for linked caDSR metadata) (search value sets) NCI Metathesaurus Link: C0004906 (see NCI Metathesaurus info) Synonyms & Abbreviations: (see Synonym Details) ...
To the editor: Williams in his article on beclomethasone dipropionate (1) consistently mentions, in his discussion of the treatment of acute asthma, supplementing aerosol therapy with oral or intravenous corticosteroid agents because of uncertain delivery of aerosol steroids in occluded airways. I believe that the use of this drug during an acute exacerbation of asthma may not only be hampered by its inability to reach the affected airway but also may be detrimental to the early reversal of bronchoconstriction.. Beclomethasone dipropionate is marketed in the United States by two pharmaceutical companies. These products are identical and contain beclomethasone dipropionate, oleic ...
Asthma is a heterogeneous disease and clinical phenotypes are highly variable. This is exemplified in the variability of patients responses to medications such as beclomethasone. It is a critical clinical question whether a particular therapy will be effective in an individual child with symptoms of asthma. At the moment, there is a lack of diagnostic tools to assess this individual responsiveness. Beclomethasone is an inhaled corticosteroid (ICS) used as controller therapy in children with asthma, providing protection against bronchial hyperresponsiveness (BHR) and exercise induced bronchoconstriction (EIB). A single dose of an ICS can have a significant effect on BHR measured by a bronchial provocation test (BPT). This rapid response shows variability similar to the variable responsiveness to long term treatment. We hypothesized that the effect of a single dose of beclomethasone on a BPT (a mannitol challenge) could predict the effect of longterm therapy with beclomethasone on BHR ...
Beclomethasone is a steroid that prevents the release of substances in the body that cause inflammation. Beclomethasone nasal (for the nose) is used to treat symptoms such as congestion, sneezing, and runny nose caused by seasonal or year-round allergies. The Beconase brand of this medication is also used to keep nasal...
Buy Beclomethasone Aq online. Beclomethasone Aq is used to prevent allergy symptoms including sneezing, itching, and runny or stuffed nose.
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The IUPHAR/BPS Guide to Pharmacology. beclometasone dipropionate ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (Multum) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum
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Inuvair® is a novel fixed combination product used in the treatment of asthma and under clinical development for the treatment of COPD. Thanks to the extrafine particle size, it is able to target the whole bronchial tree, including the small airways and hence, is expected to act in these airways and it may thus be beneficial in COPD in that sense. In COPD, its action on the small airways is not directly demonstrated thus far. By way of contrast, dear evidence is present that treatment with bronchodilators alone does not beneficially alter small airway function. The study hypothesis states that the effects of inhaled corticosteroids or ICS/LABA combinations on small airway is present and can be objectivated ...
First Waterless Nasal Allergy Spray Approved for Children as Young as Four Years of Age JERUSALEM--(BUSINESS WIRE)-- Teva Pharmaceutical Industries Ltd. (TEVJF), (NYSE:TEVA) announced today that the...
Beclomethasone: An anti-inflammatory, synthetic glucocorticoid. It is used topically as an anti-inflammatory agent and in aerosol form for the treatment of ASTHMA.
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Easy to read patient leaflet for Beclomethasone Nasal Spray. Includes indications, proper use, special instructions, precautions, and possible side effects.
BECLOMETHASONE (be kloe METH a sone) is a corticosteroid. It helps decrease inflammation in your lungs. This medicine is used to treat the symptoms of asthma. Never use this medicine for an acute asthma attack.
BECONASE AQ (Beclomethasone) drug information & product resources from MPR including dosage information, educational materials, & patient assistance.
This part of the eMedTV site covers a number of topics on beclomethasone, including what to do if you miss a dose, how to store it, what to do if you take too much, safety issues to discuss with your doctor, and whether drug interactions are a concern.
chemBlink provides information about CAS # 113-38-2, Estradiol 3,17-dipropionate, Ovocyclin P, Ovocyclin dipropionate, Progynon DP, beta-Estradiol dipropionate, molecular formula: C24H32O4.
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Status: Active. Support: Teva. Registration:. Short Description. The objective of this study is to investigate the real life effectiveness of ICS delivery of Fluticasone Propionate (FP) and Qvar® (beclomethasone dipropionate HFA) by pMDI with spacer compared to pMDI alone. Documents and Publications. Qvar_FD_Spacer_Protocol. Abstracts. Presentations. Final Publications. Additional Material. ...
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This sheet talks about exposure to inhaled corticosteroids in pregnancy and while breastfeeding. This information should not take the place of medical care and advice from your healthcare provider.. What are inhaled corticosteroids? Inhaled corticosteroids (ICSs) are medications to prevent and control the symptoms of asthma. ICSs are taken using an inhaler, pump, or nebulizer. ICSs can have fewer side effects than corticosteroids pills since most of the inhaled medication goes directly to the lungs instead of traveling throughout the body.. ICSs help control the swelling of the airways in the lungs and reduce mucus production so that asthma attacks are less likely. ICSs are not effective in stopping immediate symptoms when you are having an asthma attack. Some examples of ICSs are beclomethasone dipropionate (Qvar®), budesonide (Pulmicort®), fluticasone propionate (Flovent®), mometasone furoate (Asmanex®), or triamcinolone acetonide (Azmacort®).. This fact sheet will focus on ...
Aim of this study was to assess the effects of extrafine beclomethasone⁄formoterol treatment on lung hyperinflation and airway geometry in COPD. Data of lobar volume (%pred) and specific lobar airway volumes (siVaw) at FRC and TLC were obtained with functional imaging in 25 COPD patients (GOLD II 14, III 7, IV 4) pre- and 4h post-bronchodilator (post BD) both at baseline and after 6 months of treatment. A post BD drop was observed for both functional residual capacity (FRC) and total lung capacity (TLC) lobar volumes at baseline (FRC:-10%,p,0.01;TLC:-2%,p,0.01) and after 6 months (FRC:-12%,p,0.01;TLC:-2%,p,0.01) as index of reduced hyperinflation. siVaw did increase 4 hours after administration at both time points (+10%,p,0.01, and +8%,p,0.01). ...
Beconase AQ is used for treating nasal allergy symptoms. It is also used to prevent recurrence of nasal growths (polyps) after surgical removal.. Buy Vancenase aq
A Medline search (1966 to June 2009) was carried out to identify all placebo-controlled randomized trials, and observational reports for safety issues, with Dexamethasone, Budesonide (BUD), Fluticasone propionate (FP), Fluticasone furoate (FF), Flunisolide, Mometasone furoate (MF), Triamcinolone (TRIAM), and Beclomethasone dipropionate (BDP) as treatment for AR. Data on three efficacy (nasal symptoms, ocular symptoms, global assessment) and three safety outcomes (epistaxis, growth, systemic ocular effects) were extracted. Meta analyses were performed for each INS and outcome and results were categorised into scores by quartiles. Scores of the three efficacy and safety outcomes were summed up to create summation scores for efficacy (ES) and side effects (AES), respectively with a maximum of 9 points. The TIX was then defined as the ratio of ES and AES ...
The hypothesis that eosinophilic airway inflammation is present in many patients presenting with respiratory symptoms suggestive of asthma but with normal lung function was tested. Thirty-six consecutive patients presenting with these features were studied. Twenty-five asthmatics and 43 healthy volunteers served as control groups. Signs of eosinophilic inflammation in blood and induced sputum were studied. Patients with respiratory symptoms were single-blindly treated with inhaled beclomethasone dipropionate (BDP), 800 microg daily, or placebo for 3 months, and re-examined at 3 months and 1 yr. Patients with respiratory symptoms had higher numbers of blood and sputum eosinophils than healthy persons (p,0.0001), but the degree of eosinophilic inflammation was less pronounced than in asthmatics (p,0.01). Three-months treatment with BDP significantly reduced total symptom score (p,0.001), cough score (p,0.0001), and the number of blood eosinophils (p,0.01). For cough alone, the improvement was ...
There are few data directly comparing CIC to other ICS and no published evidence directly comparing CIC to BDP specifically. None of the RCTs showed CIC to offer any benefit over BUD or FP for effectiveness i.e. none of the RCTs showed CIC to offer any benefit over BUD or FP for any patient based outcomes (asthma symptoms or QoL in these trials). Furthermore none of the trials demonstrated any benefit from CIC over BUD or FP for indirect outcomes of efficacy i.e. lung function, improving response to AMP or metacholine as provoking agents or for decreasing markers of inflammation.. All but one of the trials were sponsored by drug companies manufacturing CIC and seem to endeavour to demonstrate CIC to have equivalent efficacy to other ICS but with an improved safety profile. However, none of the studies report analyses which exclude superiority of one treatment over another (hence it is not possible to conclude that CIC was equivalent to FP or BUD for any efficacy outcomes) and the evidence ...
IL-33 targeting ST2 receptor (T1/ST2), expressed on Th2 cell surface, regulates the production of cytokines like IL-17A and IL-31.We studied the role of IL-33/ST2 axis in IL-31 and IL-17A production in patients with allergic rhinitis (AR) and with concomitant allergic asthma and rhinitis (AAR).20 healthy control subjects (HC), 14 AR and 17 AAR subjects were recruited and blood samples collected. IL-33, soluble ST2 (sST2), IL-17A and IL-31 plasma concentrations were measured by ELISA method. T1/ST2, IL-31 and IL-17A cellular expression were studied in peripheral blood mononuclear cells (PBMC) from HC, AR and AAR (n =6 for each group) by flow-cytometry. In vitro, we also evaluated the effect of beclomethasone dipropionate (BDP) on T1/ST2, IL-31 and IL-17A expression in CD3+T-cells from PBMC of AAR (n =6).Plasma levels of IL-33, IL-31 and IL-17A were significantly higher and sST2 was lower in patients with AR and AAR than in HC. IL-31 and IL-17A intracellular levels significantly increased, whereas ...
PRINCETON, N.J., Feb. 1, 2011 /PRNewswire/ -- Soligenix, Inc. (OTC Bulletin Board: SNGX [1]) (Soligenix or the Company), a late-stage biopharmaceutical company, announced today that it has appointed Kevin Horgan, MD, as its Senior Vice President and Chief Medical Officer. Dr. Horgan is a board-certified gastroenterologist with a research background in cellular immunology and experience in the care of patients with inflammatory bowel disease, including graft-versus-host disease (GVHD). He has had a long and distinguished career of more than 25 years in both academia and industry, most notably with Merck, Centocor, and GE Healthcare. Dr. Horgan will lead Soligenixs clinical research with primary focus on the execution and completion of its confirmatory Phase 3 clinical trial of orBec® (oral beclomethasone dipropionate or BDP) in the treatment of acute gastrointestinal (GI) GVHD.. While with Merck, Dr. Horgan led the development of the first neurokinin-1 receptor antagonist, EMEND®, which was ...
Clotrimazole + beclomethasone dipropionate + neomycin creams are an imidazole derivative with a broad spectrum of antimycotic activity.
BACKGROUND: Symptom-based adjustment (SBA) of inhaled corticosteroids may be an alternative patient-centered approach in which day-to-day inhaled corticosteroid use is adjusted by symptoms and short-acting ß-agonist need. OBJECTIVE: To evaluate the effectiveness of SBA in the primary care setting. METHODS: We conducted a randomized, open-label, pragmatic equivalence trial in African-American children (6-17 years old) with mild asthma managed by 12 primary care providers (PCPs). A total of 206 participants were randomized to SBA (as-needed beclomethasone 80 µg with rescue short-acting ß-agonist) or provider-based guideline-directed adjustment (PBA): maintenance beclomethasone 80 µg/d (6-11 years old), 160 µg/d (12-17 years old), with subsequent guideline-based dose adjustment by PCPs. PCPs implemented both treatment assignments, with outcomes measured by blinded staff. All participants received symptom recognition and albuterol use education from peer educators. Primary outcome was change in ...
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Introduction to James, aged 42 years old. James has a long history of respiratory problems dating back to his childhood. He regularly suffered from coughs and chestiness and tended to avoid sports and outdoor activities because of this, as he found these made his symptoms worse. James can remember being told by his GP that he had asthma, but he could not recall having any investigations at the time.. He was prescribed a beclometasone preparation at an equivalent dose of 200mcg bd (eg. QVAR® (Beclometasone dipropionate HFA) 100mcgs bd), along with salbutamol to use as required. However he was not always able to afford the prescription charge for both items. James only earning the minimum wage as a sales assistant often resulted in his only being able to afford one of the inhalers prescribed. He then chose to get the reliever, as he felt this was the more effective and quicker in onset, and forgoing his preventer (inhaled steroid).. He rarely attended for review stating that if he did not ...
This study compared the pharmacokinetics and pharmacodynamics of different doses of beclometasone/formoterol [Foster; Chiesi], in combination with charcoal, in
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This eMedTV page contains a list of things to discuss with your doctor before starting treatment with Qvar, such as your current medications. Other topics discussed in this segment include overdose information, storage, and what to do if you miss a dose.
Indications for ENSTILAR (calcipotriene and betamethasone dipropionate aerosol, foam) refers to the medical reasons for why ENSTILAR is used and recommended as a treatment.
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... , QVAR (beclomethasone dipropionate) HFA Inhalation Aerosol is an inhaled steroid for asthma and bronchitis for use in cats and dogs with chronic bronchitis or daily asthma symptoms. Available
Forty-nine patients were randomised; 45 (92%) received all five treatments. Non-inferiority was demonstrated between the DPI and pMDI formulations at both doses (-0.2 bpm [95% CI -1.3, 0.9] for 200/12 μg and 0.6 bpm [-0.5, 1.7] for 800/48 μg). Although there were statistically significant treatment-placebo differences at both doses and with both devices (thus confirming assay sensitivity), these differences were small and well below 5 bpm for the 200/12 μg dose. The results for the secondary parameters (QTcF, glucose and potassium) further supported the therapeutic equivalence of the two treatments. At the therapeutic dose, there were no clinically relevant treatment-placebo differences in any parameter with either formulation. There was no increase in the proportion of patients reporting AEs whilst receiving therapeutic doses of BDF/FF (either formulation) compared with placebo.. CONCLUSIONS ...
The Global and Chinese Betamethasone 1721-dipropionate Industry, 2010-2020 Market Research Report is a professional and in-depth study on the current state of the global Betamethasone 1721-dipropionate industry with a focus on the Chinese market. The report provides key statistics on the market status of the Betamethasone 1721-dipropionate manufacturers and is a valuable source of guidance and dir
The potency of a topical corticosteroid depends on the formulation. Potency is also increased when a formulation is used under occlusive. TOPICAL CORTICOSTEROID POTENCY. Topical steroid preparations are grouped according to relative anti-inflammatory activity, but activity may vary.. COLONOSCOPY PREP with Morphine Citrate and Dulcolax. Sack you for choosing us for your prednisolone topical potency care needs. This violence is to help prevent and give you miss to follow. If you have any antibiotics, please ask your list or nurse. You have been associated for a Colonoscopy on. Rough the dose in women with a fatal cesarean section. Eur J Respir Dis Suppl. ; Topical and systemic glucocorticoid potencies of budesonide, beclomethasone dipropionate and prednisolone in man. There is little point in diluting a topical steroid, as their potency does not depend much on concentration. After the first 2 or 3 applications, there is no additional.. ...
A 59-year-old woman received 600 mg (7.2 mg/Kg) RIF and 2000 mg (24 mg/Kg) PZA daily after testing revealed a TST with 27 mm induration and no findings for active TB. She chose this regimen because of suspected exposure to drug-resistant TB and concern about liver injury from INH. In addition to RIF-PZA, she received beclomethasone dipropionate nasal spray, budesonide inhalation powder, and albuterol inhalation aerosol for nasal allergies and asthma. She had no history of liver disease, rarely drank alcohol, and did not inject drugs. She was vaccinated against hepatitis A but not B. She had a history of anaphylactic reactions to penicillin and an estrogen sulfates blend. Baseline ALT and AST, bilirubin levels, and blood cell counts were normal. She was instructed to contact her health-care provider about adverse effects during treatment. On day 2 of treatment, she reported queasiness. On day 17, her blood tests were repeated: serum aminotransferase and bilirubin levels were normal, and her ...
Beconase AQ Nasal Spray ( whose generic is called Beclomethasone Dipropionate, Monohydrate) is a medicine used for the treatment of hay fever. It is a type of nasal inflammation, which happens when the immune system overreacts to allergens in the air. The common symptoms of this disease are: sneezing, nasal congestion, sniffles, itching and common cold symptoms.
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.. Infection: Corticosteroids such as beclomethasone can mask the signs of infection. You can also develop other infections such as a fungal throat infection. Talk to your doctor as soon as possible if you develop any new symptoms.. Medical conditions: If you have asthma, thyroid problems, or liver disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.. Other corticosteroid medications: If you have been taking oral corticosteroids and are starting beclomethasone nasal spray, your doctor should carefully monitor your condition. ...
lightheadedness.. Whats the best way to store Beconase AQ? You should be sure to keep the medication in a safe place and at room temperature or 15 C to 30 C (59 F to 86 F). Before using it make sure to shake it properly.. How should it be taken? The typical dose for these inhalers is about 1-2 sprays in each nostril at least twice a day. The alternative is 2 sprays in each nostril once a day.. Why choose Beconase AQ over other options on the market? This medication has been shown to relieve the symptoms of hay fever better than a lot of drugs on the market can. Its designed to attack in a more precise way. The only negative for some people is they say the drug can leave a bad taste in their mouth or at times it can create a burning sensation in the nostrils. For these people it might take a little while to get used to using the drug, but if you experience a burning sensation and it persists then you should consult a doctor.. Where to purchase? The best place to purchase Beconase AQ would be at ...
and corpulmonale that requires surgical intervention, less obstruction can have some problem for children that needs non-invasive procedures Methods: This controlled clinical trial study included thirty children 5 to 12 years old exhibiting obstructive nasal symptoms. During one month, treatment group received two sprays in each nostril twice daily [336 wg/day] Results: After 4week period, studied gronp showed significant improvent in airway size, compared with controlled group [p= 0.05 vs p = 0.3] . Although adenoidal size decreased in the treatment group [mean 6%], this was not significant. Also, hearing improvement was significant in treatment group [p = 0.02] with no improvement in controlled group. Among five symptoms nasal congestion, rhinolallia, snoring, day time somnolence and restless sleep, significant improvement was seen in three: nasal congestion [p = 0.01] snoring [p = 0.001] and restless sleep [p = 0.04] . Rhinolallia and daytime somnolence were partially improved Conclusion: ...
Foster® Spray & Foster® NEXThaler®. This is a fixed combination for inhalation of beclometasone dipropionate (anti-inflammatory) plus formoterol fumarate (bronchodilator). The spray-formulated product (pMDI, Modulite®) releases extra-fine particles. The product is indicated for the treatment of asthma both as a maintenance (1 or 2 puffs twice daily) and MART (Maintenance and Reliever Therapy) posology scheme. The latter allows the use of Foster® also as reliever therapy (max. 6 extra puffs as needed). Foster® Spray has also obtained marketing authorisation for the COPD indication. The product was launched first in Germany in 2006 and is commercialised nowadays in more than 40 countries around the globe, including Russia, China and in the region of Austria and CEE, which is covered by own affiliates including many countries managed by the Multi Country Organisation.. Foster® is also available on the market as a dry powder formulation (DPI) for inhalation, dispensed in extra-fine particles ...
MODEL RELEASED. Adult female patient uses a Beclometasone inhaler to treat asthma. This hand-held disposable inhaler contains a glucocorticoid steroid drug to relieve symptoms of asthma. This is a metered dose inhaler (MDI). - Stock Image C014/2724
Inhaled corticosteroids. These anti-inflammatory drugs are the most effective medications for asthma. They reduce inflammation in your airways and prevent blood vessels from leaking fluid into your airway tissues. Corticosteroids help decrease the frequency of your attacks and reduce the need for other medications you may use to control your symptoms. Because inhaled corticosteroids control most forms of asthma by delivering medication directly to your airways, they have a lower risk of side effects than are associated with oral corticosteroids. Inhaled corticosteroids include fluticasone (Flovent), budesonide (Pulmicort), triamcinolone (Azmacort), flunisolide (Aerobid) and beclomethasone (Qvar). Advair Diskus is a combination inhaler containing fluticasone and salmeterol.. Side effects associated with inhaled corticosteroids can include hoarseness or loss of voice, oral yeast infections (thrush), and cough. Long-term use of inhaled corticosteroids may slightly increase the risk of skin ...
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This study will investigate the effects of extra-fine beclometasone on small airways inflammation in patients with chronic obstructive pulmonary disease (COPD).
Background: Inhaled steroids are the most commonly used anti-inflammatory agents for asthma and are increasingly recognised as having a more rapid onset of action than was previously thought. We have investigated the effect of a single dose of inhaled steroid on nocturnal worsening of asthma. Methods: Ten patients with steroid naive moderate asthma and nocturnal asthma participated in a randomised, double blind, placebo controlled, crossover trial. Participants spent three nights in the laboratory, one week apart. On each night they underwent spirometric testing at 16.00 hours and received one of the three treatments (placebo, bedomethasone 1000 µg, or fluticasone 1000 µg) delivered by metered dose inhaler. Spirometric tests were repeated at 04.00 hours the following morning. Results: Following placebo administration the mean (SE) overnight fall in FEV[sub 1] was 0.65 (0.27) I compared with -0.02 (0.13) I following fluticasone (p = 0.019) and 0.23 (0.12) I following beclomethasone (p = ...
As many of you know Ive been suffering from severe allergies. For the last couple of days my Asthma has been really uncontrolable, and very early this morning I had a severe flare-up that landed me at the hospitol. They gave me a breathing treatment, several prescriptions for new medications. So now I am on Prednisone (and I hope I dont gain hella weight like I did that last time I took it) Proventil 2-4 puffs every 2 hours or as needed. My nebulizer which has both Liquid Albuterol and Atrovent every 4 hours, The preventative Inhaled corticosteriod Qvar (beclomethasone) and Singulair which is for both allergies and asthma and also a Nasal allergy spray. I cant excersise untill I get it under control which wont be for a few weeks, but I can walk and as long as I wear a mask I can pack and move and clean. Blah, Im so tired ive been awake since 3am and not being able to breathe is so scary. Dr told me I could have died because Asthma is so serious if it isnt under control. Now the last time My ...
OBJETIVO: Revisar os mecanismos moleculares de ação, eficácia e potenciais efeitos adversos relacionados aos corticosteróides inalados (CEI) em crianças com asma persistente. FONTES DOS DADOS: Artigos de língua inglesa da base de dados MEDLINE. Foram empregados os termos: corticosteroids, inhaled corticosteroids, asthma, children, beclomethasone, fluticasone, budesonide, ciclesonide, growth, adrenal insufficiency, bone mineral density, oral candidiasis. Foram selecionados guias de tratamento, artigos de revisão, estudos controlados, meta-análises e revisões sistemáticas que avaliaram a eficácia e os eventos adversos do tratamento com CEI. SÍNTESE DOS DADOS: Estudos in vivo e in vitro mostram que os CEI disponíveis apresentam diferentes características farmacocinéticas e farmacodinâmicas que lhes conferem diferentes potenciais de ação. Os CEI também diferem quanto aos efeitos adversos sistêmicos e locais. Salienta-se a biodisponibilidade desses produtos como essencial para ...
Controllers are medicines that prevent asthma attacks from starting. There are two types of controller medicines anti-inflammatory medicines and airway openers.. Anti-inflammatory medicines work by reducing the inflammation in the airways that occurs in asthma. The most effective and most commonly used anti-inflammatory medicines are inhaled glucocorticosteroids, such as budesonide, beclomethasone and fluticasone. These medicines help to prevent periods of greater severity of asthma if you take them regularly as instructed by your doctor (usually once or twice every day), and they may relieve you of your symptoms completely for most of the time. If your doctor gives you an inhaled glucocorticosteroid you must take it regularly, even if you are not wheezing.. If the inflammation is not controlled, the airways become red, swollen, narrower and extra-sensitive. Some degree of inflammation is usually present in your lungs, even when you are unaware of symptoms, and worsening of the inflammation may ...
Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Friedlander on lotrisone corticosteroid antibiotic combination: Beclomethasone is a steroid ; Clotrimazole is an antifungal and neither will treat acne. Neosporin is a topical antibiotic but is not commonly used to treat acne.
Mylan-Beclo AQ: Beclomethasone nasal spray belongs to a class of medications called corticosteroids. It is used to treat seasonal allergic rhinitis and perennial (year-round) allergic rhinitis.
A previously fit and well 32 year old man was admitted to the neurology ward in November 1998 with a 24 hour history of rapidly progressive leg weakness such that he was unable to stand. He felt tingling in his hands and lower legs, but no loss of sensation. Two weeks earlier he had noticed intermittent weakness in both legs. He reported no other neurological or constitutional symptoms. Twelve weeks earlier he had returned from a holiday in California.. His past medical history was unremarkable except for bronchial asthma controlled by salbutamol and beclomethasone inhalers. On further questioning, he admitted to unusually more colds than normal as well as mild fatigue and tiredness of six months duration.. On examination, he was tanned with palmar crease and buccal pigmentation. His pulse was regular at 80 beats/min, blood pressure was 130/60 mm Hg (unable to stand to check postural drop), and his temperature was normal. The remaining general physical examination was normal. Higher mental ...
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Order Qvar Aerosol from our online clinic for collection or delivery. Qvar Aerosol is an asthma inhaler that reduces your chances of having an asthma attack.
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Abstract Background The metabolic syndrome is associated with increased risk for both diabetes and coronary artery disease, which insulin resistance alone does not satisfactorily explain. We propose an additional and complementary underlying mechanism of glucocorticoid resistance. Results Using acanthosis nigricans (AN) and skin vasoconstrictor (SVC) response to topically applied beclomethasone dipropionate as markers of insulin and glucocorticoid resistance, respectively, we compared anthropometric, biochemical, pro-inflammatory markers and the SVC response in subjects with AN in two studies: STUDY 1 was used to compare subjects with AN (Grade 4, n = 32), with those without AN (n = 68) while STUDY 2 compared these responses among a cross-section of diabetic patients (n = 109) with varying grades of AN (grade 0, n = 30; grade 1, n = 24; grade 2, n = 18; grade 3, n = 25; grade 4, n = 12). Findings In both studies there was an inverse relationship between AN Grade 4 and the SVC response, (P andlt; ...
Several different genomic and non-genomic mechanisms mediate the important anti-inflammatory and immunomodulatory effects of glucocorticoids (GCs). The genomic effects are the most important while the clinical relevance of non-genomic actions is still a matter of debate. We therefore investigated whether beclomethasone and clobetasol are particularly suitable for topical application because they differ in their spectrum of activity from systemically administered GCs such as dexamethasone. We compared effects on oxygen consumption as measured with a Clark electrode (nonspecific non-genomic glucocorticoid effects), on interleukin-6 synthesis by means of ELISA (genomic effects) and on apoptosis using flow cytometry (non-genomic and genomic effects) in quiescent and mitogen-stimulated PBMCs. Beclomethasone and clobetasol had stronger effects on the oxygen consumption of quiescent and stimulated cells at lower concentrations (10-10, 10-8 M) but were less potent at higher concentrations (10-5, 10-4 M) ...
Summary of the evidence on beclometasone, formoterol and glycopyrronium (Trimbow) for chronic obstructive pulmonary disease (COPD) to inform local NHS planning
Great price on Beclometasone 200microgram inhalation powder capsules. FREE delivery options available. Trusted service, convenient and safe shopping online
Traditionally β blockers have been avoided in asthma due to concerns about acute bronchoconstriction. There is increasing evidence that cardioselective β blockers can now be used though they seldom are. In this trial stable patients with asthma on ,1000 µg/day of beclometasone dipropionate equivalent dose were randomised to propranolol or placebo (Heart 2014;100:219-23). Tiotropium was given concurrently to propranolol throughout the trial. Prior to randomisation a subgroup underwent a safety visit and received a single dose of intravenous esmolol. The trial looked at the effect of these drugs on spirometry and total airway resistance (R5%). There was no significant change in FEV1 or total airway resistance (R5%) following esmolol infusion at 2 min, 8 min, 16 min and 32 min. However there was a significant decrease in heart rate and blood pressure. For those treated with propranolol and tiotropium there was a non-significant rise in FEV1 predicted 30 min post 10 mg dose, this continued to 3 ...
The study by Milgrom and colleagues is their second on the use of omalizumab (anti-IgE antibody) in the treatment of asthma and the third published in the past 3 months that addresses treatment with anti-IgE in large, multicenter asthma studies. Concurrent studies by Busse and colleagues (1) and Soler and colleagues (2) included , 500 adult patients aged 12 to 75 years and used medium to high-dose inhaled steroids (500 to 1200 µg/d of beclomethasone). They used a design similar to that of Milgrom and colleagues and achieved similar results in terms of steroid reduction and decreases in exacerbations. These studies, along with an earlier publication by Milgrom and colleagues (3), make a case for anti-IgE antibodies as adjunctive treatment for steroid-dependent patients with asthma. The advantages of anti-IgE over conventional therapies include once or twice-monthly subcutaneous injections and its tolerability with infrequent side effects. However, many questions remain. Although the association ...
August 27th Introduction & Bac k ground Asthma was the 25th leading cause of disability adjusted life years lost worldwide in 2001, estimated to be about 15 million DALYs per year Beclomethasone inhalers and salbutamol inhalers are on the WHO EML. Recent paper in Allergy by N. Ait-Khaled, D. A. Enarson, K. Bissell, N. E. Billo. Access to inhaled corticosteroids is key to improving quality of care for asthma in developing countries. However, many patients have difficulty accessing treatment; it is a challenge for them to get their medication and so, levels of uncontrolled asthma cases remain high. Aim: Secondary analysis of price, availability and affordability of CVD medicines in 36 developing countries that have undertaken WHO/HAI surveys
Mild nasopharyngeal irritation following the use of beclomethasone aqueous nasal spray has been reported in up to 24% of patients treated, including occasional sneezing attacks (about 4%) occurring immediately following use of the spray. In patients
Mild nasopharyngeal irritation following the use of beclomethasone aqueous nasal spray has been reported in up to 24% of patients treated, including occasional sneezing attacks (about 4%) occurring immediately following use of the spray. In patients
An 88-year-old woman was admitted with a 6-month history of progressive shortness of breath, a cough productive of small volumes of clear sputum and lethargy. In the preceding 3 weeks her symptoms had worsened, also with episodes of feeling hot and shivery. Three courses of antibiotics from her GP had not improved symptoms. She had previously been given a diagnosis of late onset asthma, on the basis of several years history of shortness of breath and wheezing at night, worse in the springtime and with exposure to oil seed rape. She had no other atopic history. Symptoms had improved a little with inhaled beclomethasone 200µg, two puffs twice daily and salbutamol, as required. She was an ex-smoker with a 10-pack year history. ...
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Before using Ventolin, be sure that the canister is properly placed in the inhaler unit. Shake well before each use. Remove the protective cap from the mouthpiece and check to make sure there are no hidden foreign objects. Breathe out slowly and completely. Place the mouthpiece between your lips and try to rest your tongue flat, unless your doctor has told you otherwise. Your doctor may have told you to hold the inhaler 1 or 2 inches (2 or 3 centimeters) away from the open mouth or to use a special spacing device. As you start to take a slow deep breath, press the canister and mouthpiece together at exactly the same time. This will release a dose of Ventolin. Continue breathing in slowly and deeply and hold for as long as comfortable (up to 10 seconds), then breathe out slowly through pursed lips or your nose. If more than 1 inhalation is to be used, wait 1 minute and repeat the above steps. Keep the spray away from your eyes ...
Before using Ventolin, be sure that the canister is properly placed in the inhaler unit. Shake well before each use. Remove the protective cap from the mouthpiece and check to make sure there are no hidden foreign objects. Breathe out slowly and completely. Place the mouthpiece between your lips and try to rest your tongue flat, unless your doctor has told you otherwise. Your doctor may have told you to hold the inhaler 1 or 2 inches (2 or 3 centimeters) away from the open mouth or to use a special spacing device. As you start to take a slow deep breath, press the canister and mouthpiece together at exactly the same time. This will release a dose of Ventolin. Continue breathing in slowly and deeply and hold for as long as comfortable (up to 10 seconds), then breathe out slowly through pursed lips or your nose. If more than 1 inhalation is to be used, wait 1 minute and repeat the above steps. Keep the spray away from your eyes ...
Before using Ventolin, be sure that the canister is properly placed in the inhaler unit. Shake well before each use. Remove the protective cap from the mouthpiece and check to make sure there are no hidden foreign objects. Breathe out slowly and completely. Place the mouthpiece between your lips and try to rest your tongue flat, unless your doctor has told you otherwise. Your doctor may have told you to hold the inhaler 1 or 2 inches (2 or 3 centimeters) away from the open mouth or to use a special spacing device. As you start to take a slow deep breath, press the canister and mouthpiece together at exactly the same time. This will release a dose of Ventolin. Continue breathing in slowly and deeply and hold for as long as comfortable (up to 10 seconds), then breathe out slowly through pursed lips or your nose. If more than 1 inhalation is to be used, wait 1 minute and repeat the above steps. Keep the spray away from your eyes ...
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About OrbeShield™. OrbeShield™ is formulated for oral administration in GI ARS patients as a single product consisting of two tablets; one tablet releases BDP in the proximal portions of the GI tract and the other tablet releases BDP in the distal portions of the GI tract. BDP has been marketed in the US and worldwide since the early 1970s as the active pharmaceutical ingredient in inhalation products for the treatment of patients with allergic rhinitis and asthma. Oral BDP may also have application in treating other GI disorders characterized by severe inflammation such as Crohns disease and radiation enteritis. About Soligenix, Inc.. Soligenix is a development stage biopharmaceutical company developing products to treat serious inflammatory diseases where there remains an unmet medical need, as well as developing several biodefense vaccines and therapeutics. Soligenix is developing proprietary formulations of oral BDP (beclomethasone 17.21-dipropionate) for the prevention/treatment of ...
About OrbeShield™. OrbeShield™ is formulated for oral administration in GI ARS patients as a single product consisting of two tablets; one tablet releases BDP in the proximal portions of the GI tract and the other tablet releases BDP in the distal portions of the GI tract. BDP has been marketed in the US and worldwide since the early 1970s as the active pharmaceutical ingredient in inhalation products for the treatment of patients with allergic rhinitis and asthma. Oral BDP may also have application in treating other GI disorders characterized by severe inflammation such as Crohns disease and radiation enteritis. About Soligenix, Inc.. Soligenix is a development stage biopharmaceutical company developing products to treat serious inflammatory diseases where there remains an unmet medical need, as well as developing several biodefense vaccines and therapeutics. Soligenix is developing proprietary formulations of oral BDP (beclomethasone 17.21-dipropionate) for the prevention/treatment of ...
Betamethasone Dipropionate (bay-ta-METH-a-sone dye-PROE-pee-oh-nate) Treats skin pain, swelling, and itching. This medicine is a corticosteroid.
Betamethasone dipropionate adalah steroid glucocorticoid dengan kebolehan anti-radang dan imunosupresif. Ia digunakan sebagai krim topikal, salap, losyen atau gel (Diprolene) untuk merawat gatal-gatal dan lain-lain keadaan kulit yang kecil seperti ekzema.
Also known as diprosone or diprolene, betamethasone dipropionate is a topical glucocorticoid used as an anti-inflammatory drug. It is used to treat skin conditions and allergies as it helps to suppress the immune responses. Learn more here.
Erratum to: Calcipotriol Plus Betamethasone Dipropionate Aerosol Foam in Patients with Moderate-to-Severe Psoriasis: Sub-Group Analysis of the PSO-ABLE ...
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1. A dry powder formulation for use in a dry powder inhaler, comprising: (a) a fraction of fine particles made of a mixture comprising 90 to 99.5 percent by weight of particles of a physiologically acceptable excipient and 0.5 to 10 percent by weight of magnesium stearate, said mixture having a mass median diameter lower than 20 microns; (b) a fraction of coarse particles comprising a physiologically acceptable excipient having a mass median diameter equal to or higher than 100 microns, wherein the weight ratio between said fine particles and said coarse particles is 1:99 to 30:70 percent by weight; and (c) formoterol fumarate dihydrate in combination with beclometasone dipropionate (BDP) as active ingredients both in the form of micronized particles; wherein: (i) no more than 10% of said BDP particles have a volume diameter lower than 0.6 microns; (ii) no more than 50% of said BDP particles have a volume diameter of 1.5 microns to 2.0 microns; and (iii) at least 90% of said BDP particles have a ...
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Annexin A1, also known as lipocortin I, is a protein that is encoded by the ANXA1 gene in humans. Annexin A1 belongs to the annexin family of Ca2+-dependent phospholipid-binding proteins that have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin A1 protein has an apparent relative molecular mass of 40 kDa with phospholipase A2 inhibitory activity. Glucocorticoids (such as budesonide, cortisol, and beclomethasone) are a class of endogenous or synthetic anti-inflammatory steroid hormones that bind to the glucocorticoid receptor (GR), which is present in almost every vertebrate animal cell. They are used in medicine to treat diseases caused by an overactive immune system, including allergies, asthma, autoimmune diseases, and sepsis. Because they suppress inflammatory pathways, long-term use of glucocorticoid drugs can lead to side-effects such as immunodeficiency and adrenal insufficiency. The main mechanism of ...
Absorption Fluticasone Propionate: Healthy Subjects: Fluticasone propionate acts locally in the lung; therefore, plasma levels do not predict therapeutic effect. Trials using oral dosing of labeled and unlabeled drug have demonstrated that the oral systemic bioavailability of fluticasone propionate is negligible (,1%), primarily due to incomplete absorption and presystemic metabolism in the gut and liver. In contrast, the majority of the fluticasone propionate delivered to the lung is systemically absorbed.. Three (3) single-dose, placebo-controlled, crossover trials were conducted in healthy subjects: (1) a trial using 4 inhalations of ADVAIR HFA 230/21, salmeterol CFC inhalation aerosol 21 mcg, or fluticasone propionate CFC inhalation aerosol 220 mcg, (2) a trial using 8 inhalations of ADVAIR HFA 45/21, ADVAIR HFA 115/21, or ADVAIR HFA 230/21, and (3) a trial using 4 inhalations of ADVAIR HFA 230/21; 2 inhalations of ADVAIR DISKUS 500/50; 4 inhalations of fluticasone propionate CFC inhalation ...

Beclomethasone: Side Effects, Dosage, UsesBeclomethasone: Side Effects, Dosage, Uses

BECLOMETHASONE (be kloe METH a sone) is a corticosteroid. It helps decrease inflammation in your lungs. This medicine is used ... beclomethasone Side Effects. Inhalation solution. Side effects that you should report to your doctor or health care ... BECLOMETHASONE (be kloe METH a sone) is a corticosteroid. It helps decrease inflammation in your lungs. This medicine is used ... How to Use beclomethasone Inhalation solution. This medicine is for inhalation through the mouth. Rinse your mouth with water ...
more infohttps://www.healthline.com/drugs/beclomethasone/inhalation-solution?brand=Qvar

Beclomethasone Nasal Spray: MedlinePlus Drug InformationBeclomethasone Nasal Spray: MedlinePlus Drug Information

Beclomethasone Nasal Spray: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Each bottle of beclomethasone nasal spray should only be used by one person. Do not share beclomethasone nasal spray because ... Beclomethasone works best when used regularly. Use beclomethasone on a regular schedule unless your doctor has told you to use ... Before using beclomethasone nasal spray,. *tell your doctor and pharmacist if you are allergic to beclomethasone, any other ...
more infohttps://medlineplus.gov/druginfo/meds/a681047.html

Beclomethasone Oral Inhalation: MedlinePlus Drug InformationBeclomethasone Oral Inhalation: MedlinePlus Drug Information

Beclomethasone Oral Inhalation: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Continue to use beclomethasone even if you feel well. Do not stop using beclomethasone without talking to your doctor. Call ... Before using beclomethasone inhalation,. *tell your doctor and pharmacist if you are allergic to beclomethasone, any other ... Use beclomethasone exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor. ...
more infohttps://medlineplus.gov/druginfo/meds/a681050.html

beclomethasone nasal | Cignabeclomethasone nasal | Cigna

Beclomethasone nasal (for the nose) is used to treat symptoms such as congestion, sneezing, and runny nose caused by seasonal ... Beclomethasone is a steroid that prevents the release of substances in the body that cause inflammation. ... What is beclomethasone nasal?. Beclomethasone is a steroid that prevents the release of substances in the body that cause ... What other drugs will affect beclomethasone nasal?. Other drugs may interact with beclomethasone nasal, including prescription ...
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beclomethasone dipropionate inhaler (Qvar) Side Effectsbeclomethasone dipropionate inhaler (Qvar) Side Effects

Beclomethasone dipropionate inhaler (Qvar) a drug prescribed to control of bronchial asthma. Side effects are a mild cough, ... Patients receiving beclomethasone may develop easy bruising if enough beclomethasone is absorbed into the body from the lungs. ... What is beclomethasone dipropionate inhaler, and how does it work?. *What brand names are available for beclomethasone ... Is beclomethasone dipropionate inhaler available as a generic drug?. *Do I need a prescription for beclomethasone dipropionate ...
more infohttps://www.medicinenet.com/beclomethasone_dipropionate_inhaler/article.htm

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... is used to prevent asthma attacks in adults and children who are at least 5 years old. This ... Beclomethasone is a steroid. It prevents the release of substances in the body that cause inflammation. ... What is beclomethasone inhalation?. Beclomethasone is a steroid. It prevents the release of substances in the body that cause ... What is the most important information I should know about beclomethasone inhalation?. Beclomethasone inhalation will not work ...
more infohttps://www.adventisthealthcare.com/health/library/topic/?id=d00760a1

Beclomethasone Nasal Aerosol Information - Drugs.comBeclomethasone Nasal Aerosol Information - Drugs.com

Easy to read patient leaflet for Beclomethasone Nasal Aerosol. Includes indications, proper use, special instructions, ... What do I need to tell my doctor BEFORE I take Beclomethasone Nasal Aerosol?. *If you have an allergy to beclomethasone or any ... Nasal Polyps, Prevention beclomethasone nasal, Beconase AQ, More.... Nasal Polyps Nasonex, mometasone nasal, beclomethasone ... Do not take beclomethasone nasal aerosol by mouth. Use in your nose only. Keep out of your mouth and eyes (may burn). ...
more infohttps://www.drugs.com/cdi/beclomethasone-nasal-aerosol.html

Beclomethasone Nasal Spray Information - Drugs.comBeclomethasone Nasal Spray Information - Drugs.com

Easy to read patient leaflet for Beclomethasone Nasal Spray. Includes indications, proper use, special instructions, ... What do I need to tell my doctor BEFORE I take Beclomethasone Nasal Spray?. *If you have an allergy to beclomethasone or any ... Nasal Polyps, Prevention beclomethasone nasal, Beconase AQ, More.... Nasal Polyps Nasonex, mometasone nasal, beclomethasone ... Do not take beclomethasone nasal spray by mouth. Use in your nose only. Keep out of your mouth and eyes (may burn). ...
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Beclomethasone - The Peoples PharmacyBeclomethasone - The People's Pharmacy

Beclomethasone. Joe Graedon The Peoples Pharmacy April 1, 2000. Default Add a Comment ... This is unlikely with beclomethasone, but people with a risk of glaucoma should be periodically checked by an ophthalmologist. ... revealed that when asthma patients inhaled beclomethasone (found in Vanceril and Beclovent) for long periods of time, they ...
more infohttps://www.peoplespharmacy.com/2000/04/01/beclomethasone/

Drug of the Month: Beclomethasone - Healthy.netDrug of the Month: Beclomethasone - Healthy.net

Beclomethasone the generic name for a range of inhaled corticosteroids used to control asthma can cause cataracts, researchers ... Tagged asbeclomethasonecataractsinhaled steroidsside effectsWhat Doctors Dont Tell You ... The Blue Mountain research team say their findings are based mainly on beclomethasone, as this was more readily available at ... Drug of the Month: Beclomethasone. What Doctors Dont Tell You1 min read ...
more infohttps://healthy.net/2006/07/02/drug-of-the-month-beclomethasone/

Beclomethasone nasal: uses & side-effects | PatientsLikeMeBeclomethasone nasal: uses & side-effects | PatientsLikeMe

Find treatment reviews for Beclomethasone nasal from other patients. Learn from their experiences about effectiveness, side ... Stopped taking Beclomethasone nasal Duration. Patients. Percentage. This item is relevant to you: Less than 1 month 1 * 10% ... Currently taking Beclomethasone nasal Duration. Patients. Percentage. This item is relevant to you: 5 - 10 years 2 * 67% ... What is Beclomethasone nasal?. Category: Prescription Drugs Most popular types: Beconase AQ Qnasl Alanase Nasal Spray Apo- ...
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Beclomethasone inhaler: uses & side-effects | PatientsLikeMeBeclomethasone inhaler: uses & side-effects | PatientsLikeMe

Find the most comprehensive real-world treatment information on Beclomethasone inhaler at PatientsLikeMe. 16 patients with ... bipolar I disorder or psoriasis currently take Beclomethasone inhaler. ... Showing 3 of 5 patient evaluations for Beclomethasone inhaler Previous page 1 2 Next page ...
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Beclomethasone - definition of beclomethasone by The Free DictionaryBeclomethasone - definition of beclomethasone by The Free Dictionary

beclomethasone synonyms, beclomethasone pronunciation, beclomethasone translation, English dictionary definition of ... beclomethasone. n. A corticosteroid drug, C22H19ClO5, used in the form of its dipropionate as an inhalant to treat asthma and ... beclomethasone. Also found in: Medical.. Related to beclomethasone: beclomethasone dipropionate. bec·lo·meth·a·sone (bĕk′lə- ... Beclomethasone - definition of beclomethasone by The Free Dictionary https://www.thefreedictionary.com/beclomethasone ...
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Comparison of inhaled beclomethasone and budesonide | The BMJComparison of inhaled beclomethasone and budesonide | The BMJ

Beclomethasone is available as a 100 μg metered dose inhaler, while budesonide is available for adults only as a 200 … ... EDITOR-The conclusions reached by Pethica et al in their paper concerning the relative potency of inhaled beclomethasone and ... Comparison of inhaled beclomethasone and budesonide. BMJ 1999; 319 doi: https://doi.org/10.1136/bmj.319.7202.124a (Published 10 ...
more infohttp://www.bmj.com/content/319/7202/124.2

Beclomethasone Dipropionate - Doctors Lounge(TM)Beclomethasone Dipropionate - Doctors Lounge(TM)

Beclomethasone Dipropionate. The Pharmacology Lounge features full articles, guidelines, news and a message board all related ...
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DailyMed - QVAR - beclomethasone dipropionate aerosol, meteredDailyMed - QVAR - beclomethasone dipropionate aerosol, metered

BECLOMETHASONE DIPROPIONATE (UNII: 5B307S63B2) (BECLOMETHASONE 17-MONOPROPIONATE - UNII:5BGA9FD55H). BECLOMETHASONE ... BECLOMETHASONE DIPROPIONATE (UNII: 5B307S63B2) (BECLOMETHASONE 17-MONOPROPIONATE - UNII:5BGA9FD55H). BECLOMETHASONE ... 100 ACTUAT Beclomethasone Dipropionate 0.04 MG/ACTUAT Metered Dose Inhaler. SCD. 3. 966536. beclomethasone dipropionate 0.04 MG ... 100 ACTUAT Beclomethasone Dipropionate 0.08 MG/ACTUAT Metered Dose Inhaler. SCD. 11. 966540. beclomethasone dipropionate 0.08 ...
more infohttps://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=20682605-557b-4586-9d98-829a63091ddf

QVAR (beclomethasone dipropionate aerosol, metered) | Healthgrades.comQVAR (beclomethasone dipropionate aerosol, metered) | Healthgrades.com

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Beclomethasone-dipropionate dictionary definition | beclomethasone-dipropionate definedBeclomethasone-dipropionate dictionary definition | beclomethasone-dipropionate defined

beclomethasone-dipropionate definition: Noun (uncountable) 1. (pharmacology) A potent glucocorticoid steroid use to treat ... beclomethasone-dipropionate. (n.d.). Retrieved December 05th, 2018, from https://www.yourdictionary.com/beclomethasone- ... "beclomethasone-dipropionate." YourDictionary, n.d. Web. 05 December 2018. ,https://www.yourdictionary.com/beclomethasone- ...
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Beclosema (Beclomethasone Dipropionate) Etex FarmaceuticaBeclosema (Beclomethasone Dipropionate) Etex Farmaceutica

Beclosema information about active ingredients, pharmaceutical forms and doses by Etex Farmaceutica, Beclosema indications, usages and related health products lists
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Gen-Beclo (Beclomethasone Dipropionate) MerckGen-Beclo (Beclomethasone Dipropionate) Merck

Gen-Beclo information about active ingredients, pharmaceutical forms and doses by Merck, Gen-Beclo indications, usages and related health products lists
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SIGMA-ALDRICH Beclomethasone Dipropionate,CAS 1327543 - 45ZG89|B3022-250MG - GraingerSIGMA-ALDRICH Beclomethasone Dipropionate,CAS 1327543 - 45ZG89|B3022-250MG - Grainger

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Beclomethasone
      - Beclometasone
     Summary Report | CureHunterBeclomethasone - Beclometasone Summary Report | CureHunter

Beclomethasone: An anti-inflammatory, synthetic glucocorticoid. It is used topically as an anti-inflammatory agent and in ... Hanburys Brand of Beclomethasone Dipropionate; Apo-Beclomethasone; Apotex Brand of Beclomethasone Dipropionate; Asche Brand of ... Beclomethasone (Beclometasone). Subscribe to New Research on Beclomethasone An anti-inflammatory, synthetic glucocorticoid. It ... Beclometasone; Junik; Qvar; Beclovent; Beconase; 3M Brand of Beclomethasone Dipropionate; A & H Brand of Beclomethasone ...
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QVAR (beclomethasone dipropionate aerosol, metered) | Dosage and Administration | Healthgrades.comQVAR (beclomethasone dipropionate aerosol, metered) | Dosage and Administration | Healthgrades.com

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BECLOMETHASONE DIPROPIONATE | Springer for Research & DevelopmentBECLOMETHASONE DIPROPIONATE | Springer for Research & Development

Asthma Allergic Rhinitis Systemic Corticosteroid Cromoglycate Beclomethasone These keywords were added by machine and not by ...
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The effect of beclomethasone on height in children | CochraneThe effect of beclomethasone on height in children | Cochrane

The effects of beclomethasone or budesonide for chronic asthma. *Inhaled beclomethasone compared with placebo for chronic ... The effect of beclomethasone on height in children. During an asthma attack, the airways (passages to the lungs) narrow from ... All used beclomethasone 200 mcg twice daily delivered by dry powder Diskhaler to treat children with mild-moderate asthma. ... The review of trials found that the inhaled steroid, beclomethasone causes an average decrease in growth of about one and a ...
more infohttps://www.cochrane.org/CD001282/AIRWAYS_the-effect-of-beclomethasone-on-height-in-children
  • Beclomethasone 17 monopropionate has been shown in vitro to exhibit a binding affinity for the human glucocorticoid receptor which is approximately 13 times that of dexamethasone, 6 times that of triamcinolone acetonide, 1.5 times that of budesonide and 25 times that of beclomethasone dipropionate. (nih.gov)
  • Higher doses of inhaled beclomethasone (more than 1000 mcg/day) may result in more absorption into the body. (medicinenet.com)
  • Lake Forest, IL) executed an exclusive option with the University of Texas Medical Branch at Galveston (UTMB) (Galveston, TX) to license patent applications covering the use of oral luminally active anti-inflammatory drugs, such as orBec (oral beclomethasone diproprionate), for the treatment of irritable bowel syndrome. (thefreedictionary.com)
  • Beclomethasone diproprionate nasal spray is also used to treat nasal polyps, to prevent their return after surgery, or to prevent their increase in size. (pharmasave.com)
  • BECONASE AQ Nasal Spray is a metered-dose, manual pump spray unit containing a microcrystalline suspension of beclomethasone dipropionate, monohydrate equivalent to 42 mcg of beclomethasone dipropionate, calculated on the dried basis, in an aqueous medium containing microcrystalline cellulose, carboxymethylcellulose sodium, dextrose , benzalkonium chloride, polysorbate 80, and 0.25% v/w phenylethyl alcohol. (rxlist.com)
  • EDITOR-The conclusions reached by Pethica et al in their paper concerning the relative potency of inhaled beclomethasone and budesonide are not justified because the authors have not verified an important assumption in the paper. (bmj.com)
  • Another agreement with Celltech over Clickhaler, involving the compounds salbutamol and beclomethasone , will continue although it will be amended. (thefreedictionary.com)
  • Princeton, NJ, announced the National Cancer Institute (NCI) has awarded the company a Small Business Innovation Research (SBIR) grant to support the conduct of a Phase 2 clinical trial designed to evaluate orBec (oral beclomethasone 17, 21-dipropionate) as a treatment for the gastrointestinal (GI) manifestation of chronic Graft-versus-Host disease (GvHD). (thefreedictionary.com)
  • combined treatment consisted of one 40-mcg puff of beclomethasone with each albuterol puff used for symptom relief. (thefreedictionary.com)
  • Your doctor will need to check your progress while you are using beclomethasone nasal, to make sure this medicine is not causing harm to your nose or sinuses. (cigna.com)
  • Use beclomethasone on a regular schedule unless your doctor has told you to use it as needed. (medlineplus.gov)
  • Before using beclomethasone, tell your doctor if you have been sick or have had any infections . (cigna.com)