Killer Factors, Yeast
bcl-2 Homologous Antagonist-Killer Protein
Killer Cells, Natural
Bone marrow-derived lymphocytes that possess cytotoxic properties, classically directed against transformed and virus-infected cells. Unlike T CELLS; and B CELLS; NK CELLS are not antigen specific. The cytotoxicity of natural killer cells is determined by the collective signaling of an array of inhibitory and stimulatory CELL SURFACE RECEPTORS. A subset of T-LYMPHOCYTES referred to as NATURAL KILLER T CELLS shares some of the properties of this cell type.
Whale, Killer
Killer Cells, Lymphokine-Activated
Cytolytic lymphocytes with the unique capacity of killing natural killer (NK)-resistant fresh tumor cells. They are INTERLEUKIN-2-activated NK cells that have no MAJOR HISTOCOMPATIBILITY COMPLEX restriction or need for antigen stimulation. LAK cells are used for ADOPTIVE IMMUNOTHERAPY in cancer patients.
Hormone Antagonists
Natural Killer T-Cells
Dopamine Antagonists
Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME.
Cytotoxicity, Immunologic
Excitatory Amino Acid Antagonists
Neurokinin-1 Receptor Antagonists
Histamine H2 Antagonists
Drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the actions of histamine. Their clinically most important action is the inhibition of acid secretion in the treatment of gastrointestinal ulcers. Smooth muscle may also be affected. Some drugs in this class have strong effects in the central nervous system, but these actions are not well understood.
Interleukin 1 Receptor Antagonist Protein
Dose-Response Relationship, Drug
Muscarinic Antagonists
Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system.
Expression of apoptosis regulatory proteins of the Bcl-2 family and p53 in primary resected non-small-cell lung cancer. (1/716)
Proteins of the Bcl-2 family as well as p53 are important regulators of apoptosis. Alterations in the expression of these proteins can contribute to the formation of cancer, as well as influence tumour response to chemo- and radiotherapy. We used antibodies specific for the human Bcl-2, Mcl-1, Bax, Bak and p53 proteins to examine the expression of these apoptosis-regulating genes in 49 archival specimens of patients with radically resected non-small-cell lung cancer (NSCLC). Tumour cells containing immunostaining for the antiapoptotic proteins Bcl-2 and Mcl-1 were present in 31% and 58% of the cases evaluated, respectively, whereas immunopositivity for the proapoptotic proteins Bax and Bak was found in 47% and 58% of the samples. p53 immunopositivity was detected in 61% of the samples. The expression of Bcl-2 and p53 and the expression of Mcl-1 and Bax showed a positive association (P = 0.02 and P = 0.06 respectively), whereas the expression of Bax was inversely related to p53 (P = 0.008). The expression of Bcl-2 had a negative influence on relapse-free survival in this population of primary resected NSCLC patients (P = 0.02). The expression of p53 and Bcl-2 was significantly associated with metastasis-free survival (P < 0.01). Only patients with p53-positive tumours developed metastases during the follow-up period. Our results establish the frequent expression of the Bcl-2 family proteins Bcl-2, Mcl-1, Bax and Bak in NSCLC. It can be expected that Bcl-2 family members have no straightforward impact on clinical outcome in this disease because their interactions in the regulation of apoptosis are complex. (+info)Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis. (2/716)
Investigation of events committing cells to death revealed that a concealed NH2-terminal epitope of the pro-apoptotic protein Bak became exposed in vivo before apoptosis. This occurred after treatment of human Jurkat or CEM-C7A T-lymphoma cells with the mechanistically disparate agents staurosporine, etoposide or dexamethasone. The rapid, up to 10-fold increase in Bak-associated immunofluorescence was measured with epitope-specific monoclonal antibodies using flow cytometry and microscopy. In contrast, using a polyclonal antibody to Bak, immunofluorescence was detected both before and after treatment. There were no differences in Bak protein content nor in subcellular location before or after treatment. Immunofluorescence showed Bcl-xL and Bak were largely associated with mitochondria and in untreated cells they coimmunoprecipitated in the presence of nonioinic detergent. This association was significantly decreased after cell perturbation suggesting that Bcl-xL dissociation from Bak occurred on exposure of Bak's NH2 terminus. Multiple forms of Bak protein were observed by two dimensional electrophoresis but these were unchanged by inducers of apoptosis. This indicated that integration of cellular damage signals did not take place directly on the Bak protein. Release of proteins, including Bcl-xL, from Bak is suggested to be an important event in commitment to death. (+info)Developmental expression patterns of Bcl-2, Bcl-x, Bax, and Bak in teeth. (3/716)
The ontogenic profile of expression of four members of the Bcl-2 family (Bcl-2, Bcl-x, Bax and Bak) was examined in the mouse by immunohistochemistry using paraffin sections. All four members were expressed in changing patterns during critical stages of tooth morphogenesis. Expression was detected in epithelial cell populations including the dental lamina, internal dental epithelium (IDE; differentiating ameloblasts), stratum intermedium and stellate reticulum cells, as well as in the condensed dental mesenchyme. The temporo-spatial localization of the various members of the Bcl-2 family in dental epithelium and mesenchyme showed striking overlapping areas but often their expression patterns differed. In general, contemporaneous co-expression of the Bcl-2 and Bax proteins, and of the Bcl-x and Bak proteins was noted in various types of cells during the developmental process, with the intensity of Bcl-2>Bax and of Bak>Bcl-x. Expression was pronounced at sites where interaction between surface ectoderm and induced mesenchyme takes place, and at the enamel knot, which is regarded as organization/regulating center for tooth development. Around birth, after the structural maturation was accomplished, the expression was down-regulated. The absence of elevated expression of each of these four members of the Bcl-2 family after birth in the teeth suggests that these proteins are relevant during the accomplishment of the basic architecture but not once the structure of the tooth is established. (+info)Bak BH3 peptides antagonize Bcl-xL function and induce apoptosis through cytochrome c-independent activation of caspases. (4/716)
The Bcl-2 homology 3 (BH3) domain is crucial for the death-inducing and dimerization properties of pro-apoptotic members of the Bcl-2 protein family, including Bak, Bax, and Bad. Here we report that synthetic peptides corresponding to the BH3 domain of Bak bind to Bcl-xL, antagonize its anti-apoptotic function, and rapidly induce apoptosis when delivered into intact cells via fusion to the Antennapedia homeoprotein internalization domain. Treatment of HeLa cells with the Antennapedia-BH3 fusion peptide resulted in peptide internalization and induction of apoptosis within 2-3 h, as indicated by caspase activation and subsequent poly(ADP-ribose) polymerase cleavage, as well as morphological characteristics of apoptosis. A point mutation within the BH3 peptide that blocks its ability to bind to Bcl-xL abolished its apoptotic activity, suggesting that interaction of the BH3 peptide with Bcl-2-related death suppressors, such as Bcl-xL, may be critical for its activity in cells. While overexpression of Bcl-xL can block BH3-induced apoptosis, treatment with BH3 peptides resensitized Bcl-xL-expressing cells to Fas-mediated apoptosis. BH3-induced apoptosis was blocked by caspase inhibitors, demonstrating a dependence on caspase activation, but was not accompanied by a dramatic early loss of mitochondrial membrane potential or detectable translocation of cytochrome c from mitochondria to cytosol. These findings demonstrate that the BH3 domain itself is capable of inducing apoptosis in whole cells, possibly by antagonizing the function of Bcl-2-related death suppressors. (+info)Epstein-Barr virus encodes a novel homolog of the bcl-2 oncogene that inhibits apoptosis and associates with Bax and Bak. (5/716)
The sequenced gammaherpesviruses each contain a single viral bcl-2 homolog (v-bcl-2) which may encode a protein that functions in preventing the apoptotic death of virus-infected cells. Epstein-Barr virus (EBV), a gammaherpesvirus associated with several lymphoid and epithelial malignancies, encodes the v-Bcl-2 homolog BHRF1. In this report the previously uncharacterized BALF1 open reading frame in EBV is identified as having significant sequence similarity to other v-bcl-2 homologs and cellular bcl-2. Transfection of cells with a BALF1 cDNA conferred apoptosis resistance. Furthermore, a recombinant green fluorescent protein-BALF1 fusion protein suppressed apoptosis and associated with Bax and Bak. These results indicate that EBV encodes a second functional v-bcl-2. (+info)Developmental regulation of Bcl-2 family protein expression in the involuting mammary gland. (6/716)
Epithelial cells within the mammary gland undergo developmental programmes of proliferation and apoptosis during the pregnancy cycle. After weaning, secretory epithelial cells are removed by apoptosis. To determine whether members of the Bcl-2 gene family could be involved in regulating this process, we have examined whether changes in their expression occur during this developmental apoptotic program in vivo. Bax and Bcl-x were evenly expressed throughout development. However, expression of Bak and Bad was increased during late pregnancy and lactation, and the proteins were present during the time of maximal apoptotic involution. Thereafter, their levels declined. In contrast, Bcl-w was expressed in pregnancy and lactation but was downregulated at the onset of apoptosis. Bcl-2 was not detected in lactating or early involuting mammary gland. Thus, the pro-apoptotic proteins Bax, Bak and Bad, as well as the death-suppressors Bcl-x, Bcl-2 and Bcl-w, are synthesised in mouse mammary gland, and dynamic changes in the expression profiles of these proteins occurs during development. To determine if changes in Bak and Bcl-w expression could regulate mammary apoptosis, their effect on cultured mouse mammary epithelial cells was examined in transient transfection assays. Enforced expression of Bak induced rapid mammary apoptosis, which could be suppressed by coexpression of Bcl-w. In extracts of mammary tissue in vivo, Bak heterodimerized with Bcl-x whereas Bax associated with Bcl-w, but Bak/Bcl-w heterodimers were not detected. Thus, Bak and Bcl-w may regulate cell death through independent pathways. These results support a model in which mammary epithelial cells are primed for apoptosis during the transition from pregnancy to lactation by de novo expression of the death effectors Bak and Bad. It is suggested that these proteins are prevented from triggering apoptosis by anti-apoptotic Bcl-2 family proteins until involution, when the levels of Bcl-w decline. Our study provides evidence that regulated changes in the expression of cell death genes may contribute to the developmental control of mammary apoptosis. (+info)Tumor necrosis factor-alpha and lipopolysaccharide induce apoptotic cell death in bovine glomerular endothelial cells. (7/716)
BACKGROUND: The glomerular endothelial cell is a specialized microvascular cell type involved in the regulation of glomerular ultrafiltration. During gram-negative sepsis, glomerulonephritis, and acute renal failure, bacterial lipopolysaccharide (LPS) and tumor necrosis factor-alpha (TNF-alpha) may cause severe cell damage. Our aim was to study and compare the direct effects of TNF-alpha and LPS on the induction of apoptosis in bovine glomerular endothelial cells. METHODS: Primary bovine glomerular endothelial cells were stimulated with TNF-alpha or LPS, and apoptotic cell death was investigated by DNA fragmentation analysis, morphological studies, measurement of cytochrome c efflux and mitochondrial permeability transition, Bak, Bad, Bax, Bcl-2, Bcl-xL protein expression, and caspase-3-like protease activity. RESULTS: TNF-alpha, as well as LPS, elicited apoptotic cell death both time and concentration dependently. Along with DNA ladder formation, we detected the formation of 50 kbp high molecular weight DNA fragments, nuclear condensation, and mitochondrial permeability transition. Concerning all parameters, LPS signaling proved to be more rapid than TNF-alpha. Mechanistically, TNF-alpha-induced cell death was preceded by an efflux of mitochondrial cytochrome c into the cytosol and, subsequently, by a marked increase in the proapoptotic protein Bak and a decrease in the anti-apoptotic Bcl-xL protein content. Comparable but more pronounced effects were seen with LPS. Later, caspase-3-like protease activity was first detectable after 10 hours and was continuously increased up to 24 hours in both TNF-alpha- and LPS-stimulated cells. Correspondingly, we detected an extended cleavage of the nuclear enzyme poly(ADP-ribose) polymerase. Caspase inhibitors Z-Asp-CH2-DCB and Z-VAD-fmk blocked both TNF-alpha- and LPS-induced apoptosis in a comparable manner. Only Z-Asp-CH2-DCB was able to block apoptotic cell death completely. CONCLUSION: Both bacterial LPS and TNF-alpha potently induced apoptotic cell death in glomerular endothelial cells. Direct endotoxin-induced apoptosis may therefore be relevant in the progression of acute renal failure, which is a frequent complication of gram-negative sepsis. (+info)Human right and left colon differ in epithelial cell apoptosis and in expression of Bak, a pro-apoptotic Bcl-2 homologue. (8/716)
BACKGROUND: Propensity to colonic neoplasia differs between the right and left colon. AIMS: To examine whether this difference may be related to regional differences in epithelial apoptosis, in expression of a proapoptotic regulatory protein, Bak, and in proliferation. PATIENTS: Individuals with no history of colorectal neoplasia. METHODS: Archival blocks of colorectal tissues were immunostained for proliferating cells (antibody to Ki-67 antigen), and Bak expression (polyclonal antiserum). Cells containing DNA strand breaks, a marker of apoptosis, were identified by terminal deoxyuridine nucleotidyl nick end labelling (TUNEL). RESULTS: There were fewer TUNEL positive epithelial cells in the right colon (mean 1.2 (SE 0.1)% of all epithelial cells) than the left colon (2.2 (0.1)%, p<0.0001) or rectum (2.2 (0.3)%, p<0.05). Bak expression was less common in the right colon (mean 46 (2.3)% of epithelial cells immunoreactive) than the left colon (66 (2.7)%, p<0.0001), or rectum (67 (2.3)%, p<0.001). Bak expression and TUNEL positivity were highly positively correlated (p<0.0001). In contrast to apoptosis, mean whole crypt proliferation labelling index was similar throughout the colorectum (right colon: 15.6 (3.2)%; left colon: 13. 5 (1.2)%; rectum: 13.3 (2.3)%). CONCLUSION: The percentage of proliferating colonic epithelial cells is constant throughout the colon, but fewer epithelial cells undergo Bak mediated apoptosis in the right than in the left colon or rectum. This suggests that colonocytes may be lost by methods other than apoptosis in the right colon. (+info)
BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis
Functional interaction of Bcl-2/Bcl-xL and Bax/Bak, but | Open-i
Mechanisms of apoptosis regulation by viral oncogenes in infection and tumorigenesis
Anti BAK Antibody, clone AB04/1A2 (PrecisionAb™ Monoclonal Antibody) | Bio-Rad Antibodies (formerly AbD Serotec)
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Back Rack + Bak Flip (or similar combinations) | Nissan Frontier Forum
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Diffuse large B-cell lymphoma
... by inhibiting the apoptosis-causing proteins, Bcl-2-associated X protein and Bcl-2 homologous antagonist killer. BCL6: This ... Pharmacological inhibition of BCL-2 is effective in most B cell lymphomas, but often leads to acquired resistance due to the ... Gene and protein markers in the neoplastic cells of DLBCL, NOS that have clinical significance include CD5, MYC, BCL2, BCL6, ... As indicated in the following Treatments and prognoses section, expression of the CD20 and CD30 proteins as well as the CD19, ...
Photoactivated peptide
The same design principle has been applied to inhibit protein-protein interactions involved in cancer and can be used for any ... Chemistry portal Biology portal Photochromism Azobenzene Spiropyran Diarylethene Photodynamic therapy Bcl-2 Bak (Bcl-2 ... homologous antagonist killer) Bid (BH3 interacting-domain death agonist) Luis Moroder, G. Andrew Woolley, Rudolf K. Allemann, ... Photoswitchable peptides to inhibit protein-protein interactions in a light-controlled manner have been developed and applied ...
Bak
... a protein involved in pro-apoptotic action Biking Across Kansas Basic Aeronautical Knowledge Bäk, a municipality in the ... a DOS-based role-playing video game Bill and keep reciprocal payment in telecommunications systems Bcl-2 homologous antagonist ... killer, ...
Cancer immunology
Another example of TSAs are abnormal products of mutated oncogenes (e.g. Ras protein) and anti-oncogenes (e.g. p53). Tumor- ... Bcl-2, IAP or XIAP. Production of TGF-β by tumor cells and other cells (such as myeloid-derived suppressor cell) leads to ... TSAs can be products of oncoviruses like E6 and E7 proteins of human papillomavirus, occurring in cervical carcinoma, or EBNA-1 ... Weon JL, Potts PR (December 2015). "The MAGE protein family and cancer". Current Opinion in Cell Biology. 37: 1-8. doi:10.1016/ ...
Bcl-2
These pro-apoptotic proteins are in turn activated by BH3-only proteins, and are inhibited by the function of BCL-2 and its ... encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L)". The ... The pro-apoptotic proteins in the BCL-2 family, including Bax and Bak, normally act on the mitochondrial membrane to promote ... Tagami S, Eguchi Y, Kinoshita M, Takeda M, Tsujimoto Y (November 2000). "A novel protein, RTN-XS, interacts with both Bcl-XL ...
Bcl-2 homologous antagonist killer
This protein also interacts with the tumor suppressor P53 after exposure to cell stress. BAK1 is a pro-apoptotic Bcl-2 protein ... "Entrez Gene: BAK1 BCL2-antagonist/killer 1". Westphal D, Kluck RM, Dewson G (February 2014). "Building blocks of the apoptotic ... The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act ... two proteins of the mitochondrial protein sorting and assembly machinery, are essential for Bak activation during TNF alpha ...
List of MeSH codes (D12.644)
... bcl-associated death protein MeSH D12.644.360.075.718.400 - bcl-2-associated x protein MeSH D12.644.360.075.718.750 - bcl-2 ... homologous antagonist-killer protein MeSH D12.644.360.075.718.937 - bcl-x protein MeSH D12.644.360.075.718.968 - bh3 ... x-linked inhibitor of apoptosis protein MeSH D12.644.360.075.718 - proto-oncogene proteins c-bcl-2 MeSH D12.644.360.075.718.100 ... 14-3-3 proteins MeSH D12.644.360.024.318 - proto-oncogene proteins c-crk MeSH D12.644.360.024.326 - proto-oncogene proteins c- ...
Reactive oxygen species
In the intrinsic pathway, ROS function to facilitate cytochrome c release by activating pore-stabilizing proteins (Bcl-2 and ... Bcl-xL) as well as inhibiting pore-destabilizing proteins (Bcl-2-associated X protein, Bcl-2 homologous antagonist/killer). The ... causing oxidized protein levels to increase. This led researchers to conclude that oxidation of cellular proteins is ... The altered protein expression in neurons, controlled in part by ROS-dependent demethylation of CpG sites in gene promoters ...
List of MeSH codes (D12.776.476)
... bcl-associated death protein MeSH D12.776.476.075.718.400 - bcl-2-associated x protein MeSH D12.776.476.075.718.425 - bcl-2 ... homologous antagonist-killer protein MeSH D12.776.476.075.718.875 - bcl-x protein MeSH D12.776.476.075.718.937 - bh3 ... smad1 protein MeSH D12.776.476.024.417.500.200 - smad2 protein MeSH D12.776.476.024.417.500.300 - smad3 protein MeSH D12.776. ... smad proteins, inhibitory MeSH D12.776.476.024.417.249.600 - smad6 protein MeSH D12.776.476.024.417.249.700 - smad7 protein ...
Flavonoids isolated from Citrus platymamma induced G2/M cell cycle arrest and apoptosis in A549 human lung cancer cells
... associated X protein/Bcl‑extra large ratio in A549 cells. These findings suggest that FCP induced G2/M arrest and apoptosis of ... Slee EA, Adrain C and Martin SJ: Serial killers: ordering caspase activation events in apoptosis. Cell Death Differ. 6:1067- ... The protein content was quantified using a Bradford assay (Bio-Rad Laboratories, Inc.). Proteins were separated by 12% sodium ... whereas the expression of the proapoptotic Bax protein was unchanged, and the ratio of Bax/Bcl-xL was dose-dependently ...
Hormone Research
... bcl-X protein - metabolism ; Proto-oncogene proteins c-bcl-2 - metabolism ; Blotting, Western. Charakt. formalna: Zagraniczne ... Angielskie s owa kluczowe: Graves' disease - pathology ; Goiter, nodular - pathology ; Proto-oncogene proteins c-bcl-2 - ... Tytu orygina u: Identification of proapoptotic (BAK,BAX) and antiapoptotic (BCL-xL), BCL-2) proteins in thyrocytes from ... Proto-oncogene proteins c-bcl-2 - biosynthesis ; Thyrotropin - blood ; Thyroxine - blood ; Triiodothyronine - blood. Charakt. ...
E4BP4 facilitates glucocorticoid-evoked apoptosis of human leukemic CEM cells via upregulation of Bim
BH3-only proteins of the Bcl-2 family, Bim and Puma, are required for the initiation of apoptosis by multiple stimuli, ... To confirm that Dex-dependent cell death and E4BP4 and Bim upregulation are dependent on GR, the effects of the GR antagonist ... E4BP4 has been shown to induce differentiation in monocyte-macrophages [50], to drive natural killer cell lineage development [ ... The mouse and human E4BP4 genes are highly homologous, with 79% nucleotide sequence identity in the coding region. The two ...
Rat BAK1(BCL2 Antagonist/Killer 1) ELISA Kit - Rat BAK1(BCL2 Antagonist/Killer 1) ELISA Kit Exporter, Importer, Manufacturer,...
BCL2 Antagonist/Killer 1) ELISA Kit based in Delhi, India ... Rat BAK1(BCL2 Antagonist/Killer 1) ELISA Kit. *Rat BAX(BCL-2 ... Rat SP-A1(Pulmonary surfactant-associated protein A1) ELISA Kit. *Rat SP-A1(Pulmonary surfactant-associated protein A1) ELISA ... Rat BAK1(BCL2 Antagonist/Killer 1) ELISA Kit Synonyms:BAK, BAK-LIKE, BCL2L7, CDN1, Bcl-2 Homologous Antagonist/Killer. Intended ... Get a price quote for Rat BAK1(BCL2 Antagonist/Killer 1) ELISA Kit ...
oncologischonderzoek.nl - Nieuws
... protein flare C SCANS studie C-486 C-ALCL C-ETACs as hallmarks of cancer C-ion RT C-reactive protein C-reactive protein ... BBD-BC BCBM BCC BCCs BCCSS BCG BCG vaccination in childhood BCG-unresponsive non-muscle-invasive bladder cancer BCIN+ BCIS Bcl- ... agonists versus GnRH antagonists CVD risk factors CVD risk factors and colorectal cancer CVEs CVSS-studie CXB CXCL8-CXCR1 2 ... levels cytokine-induced killer cell therapy cytokines cytology testing cytoreductive surgery Cytosponge-trefoil factor 3 D-2- ...
فاکتور رشد اندوتلیال عروقی (VEGF) | دانلود مقالات ISI فاکتور رشد اندوتلیال عروقی (VEGF) | 4434 مقاله انگلیسی + ترجمه فارسی
Keywords: فاکتور رشد اندوتلیال عروقی (VEGF); AP-1; activator protein-1; Bax; Bcl-2-associated X protein; Bcl-2; B cell lymphoma ... C/EBP-homologous protein 10; DNA; dezoxiribonucleic acid; FITC; fluorescein isothiocyanate; GAPDH; (Glyceraldehyde 3-phosphate ... Keywords: فاکتور رشد اندوتلیال عروقی (VEGF); AMPK; AMP-activated protein kinase; ARF6; ADP-ribosylation factor 6; AKT; protein ... autophagy protein; BAK; Bcl 2 homologous antagonist/killer; BAX; Bcl-2 associated -X protein; Bcl-2; B- ...
CARD R-BASE
Sperm postacrosomal WW domain-binding protein is not required for mouse egg activation. C/EBP homologous protein deficiency ... Bcl-xL Displays Restricted Distribution during T Cell Developement and Inhibits Multiple Forms of Apoptosis but Not Clonal ... T Cell Receptor Antagonist Peptides Induce Positive Selection. Tissue-specific knockout of the mouse Pig-a gene reveals ... Reversible Defects in Natural Killer and Memory CD8 T Cell Lineages in Interleukin 15-deficient Mice. Differential T Cell ...
Chinese Journal of Physiology : Table of Contents
... homologous antagonist killer (Bak), BCL-2-associated X protein (Bax), and cytochrome c at both the mRNA and protein levels were ... and MCP-1 protein expression, increase IκB protein expression in HPASMCs. According to what we observed, this study indicated ... and increased cell cycle inhibitor proteins p21. Besides, ASE decreased the total protein level of epidermal growth factor ... At the cellular and molecular levels, we found that 18β-GA could significantly reduce the accumulation of misfolded protein in ...
mRNA vaccines - a new era in vaccinology | Nature Reviews Drug Discovery
B cell lymphoma 6 protein (BCL-6), was identified183,184,185. TFH cells represent a specialized subset of CD4+ T cells that ... Self-amplifying mRNA vaccines expressing multiple conserved influenza antigens confer protection against homologous and ... antagonist increased the cytolytic capacity of CD8+ T cells and modestly delayed tumour growth in OVA-expressing lymphoma or ... Tumor associated antigen and interleukin-12 mRNA transfected dendritic cells enhance effector function of natural killer cells ...
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Protein metabolism ]] #[[Prozone ]] #[[Robert W. Holley ]] #[[Röntgen equivalent man ]] #[[SUMO protein ]] #[[ ... Homologous series ]] #[[ICD-10 Chapter K ]] #[[Cementum ]] #[[Chronic stable angina historical perspective ]] #[[Cluster of ... Antagonist (muscle) ]] #[[Anti-ganglioside antibodies ]] #[[Arcuate vein ]] #[[Arene substitution patterns ]] #[[ATC code H ... Natural Killer T cell ]] #[[Dichloromethane ]] #[[Extensor hallucis longus muscle ]] #[[Exudate ]] #[[Failure to thrive ...
Polymerase Chain Reaction | [email protected]
Protein fabrication automation. * Protein isoforms encoded by the pX region of human T-cell leukemia/lymphotropic virus type I. ... Frequent detection of bcl-2/JH translocations in human blood and organ samples by a quantitative polymerase chain reaction ... Identification and mapping of type 1 neurofibromatosis (NF1) homologous loci. * Identification of Aedes aegypti and its ... cDNA cloning of an intracellular form of the human interleukin 1 receptor antagonist associated with epithelium. ...
Dr Girish Patel - People - Cardiff University
Expression of WAVEs, the WASP (Wiskott-Aldrich syndrome protein) family of verprolin homologous proteins in human wound tissues ... The role of Bik1 (BCL-2 interaction killer) in wound healing [Abstract]. Wound Repair and Regeneration 18(6), pp. A92. (10.1111 ... for resistance and recurrence after conventional chemotherapy and also the recently introduced smoothened antagonists. ... Expression of WAVEs, the WASP (Wiskott-Aldrich syndrome protein) family of verprolin homologous proteins in human wound tissues ...
Studies on IKK | Interstellar Blends | Activate Your Super Powers!
antagonist blocks histamine-induced proinflammatory cytokine production through inhibition of Ca2+-dependent protein kinase C, ... Regulation of expression of Bcl-3 proto-oncogene by IKK ϵ. *Regulation of I-kappa-B kinase (IKK) Pathway by CARMA 1• Bcl-10• ... IKK-i and TBK-1 are Enzymatically Distinct from the Homologous Enzyme IKK-2 COMPARATIVE ANALYSIS OF RECOMBINANT HUMAN IKK-i, ... Deficient natural killer cell cytotoxicity in patients with IKK-γ/NEMO mutations ...
RegenerativeMedicine.net - Article Archives
... promotes cancer metastasis through resistance to anoikis and increased invasiveness Co-targeting of BAX and BCL-XL proteins ... Reparative effects of interleukin-1 receptor antagonist in young and aged/co-morbid rodents after cerebral ischemia Epithelial- ... pylori infection in a pig model is dominated by Th1 and cytotoxic CD8+ T cell responses Epigenetic control of natural killer ... microtissue and its application for adverse drug reaction assay Non-catalytic roles for XPG with BRCA1 and BRCA2 in homologous ...
Apoptosis - WikiProjectMed
Many viruses encode proteins that can inhibit apoptosis.[104] Several viruses encode viral homologs of Bcl-2. These homologs ... such as Natural Killer and cytotoxic T cells) that then induce the infected cell to undergo apoptosis.[99] ... The adenovirus E1B-55K protein and the hepatitis B virus HBx protein are examples of viral proteins that can perform such a ... these inhibitory proteins target retinoblastoma tumor-suppressing proteins.[84] These tumor-suppressing proteins regulate the ...
RegenerativeMedicine.net - Article Archives
... promotes cancer metastasis through resistance to anoikis and increased invasiveness Co-targeting of BAX and BCL-XL proteins ... Reparative effects of interleukin-1 receptor antagonist in young and aged/co-morbid rodents after cerebral ischemia Epithelial- ... pylori infection in a pig model is dominated by Th1 and cytotoxic CD8+ T cell responses Epigenetic control of natural killer ... microtissue and its application for adverse drug reaction assay Non-catalytic roles for XPG with BRCA1 and BRCA2 in homologous ...
An integrative analysis of cellular contexts, miRNAs and mRNAs reveals network clusters associated with antiestrogen-resistant...
... protein-coding genes corresponding to TFs (from TransmiR), and signaling proteins (from TransmiR). The triangle denotes the ... Guirouilh-Barbat JK, Wilhelm T, Lopez BS: AKT1/BRCA1 in the control of homologous recombination and genetic stability: the ... MicroRNA-125b confers the resistance of breast cancer cells to paclitaxel through suppression of pro-apoptotic Bcl-2 antagonist ... killer 1 (Bak1) expression. J Biol Chem. 2010, 285: 21496-21507. 10.1074/jbc.M109.083337. ...
Carcinoma, endometrioid - pathology
... bcl-X protein - metabolism. Charakt. formalna: Zagraniczny artyku Charakt. merytoryczna: Praca oryginalna. J zyk publikacji: ... Tytu orygina u: Coexistence of homologous-type cervical carcinosarcoma with endometrioid-type G1 endometrial cancer: a case ... bcl-X protein - metabolism. Charakt. formalna: Zagraniczny artyku Charakt. merytoryczna: Praca oryginalna. J zyk publikacji: ... bcl-X protein - metabolism. Charakt. formalna: Zagraniczny artyku Charakt. merytoryczna: Praca oryginalna. J zyk publikacji: ...
Mitochondrial double-stranded RNA triggers antiviral signalling in humans. - MRC Weatherall Institute of Molecular Medicine
2. However, to our knowledge, mitochondrial double-stranded RNA has not been previously characterized in vivo. Here we describe ... bcl-2 Homologous Antagonist-Killer Protein, bcl-2-Associated X Protein ... 2. However, to our knowledge, mitochondrial double-stranded RNA has not been previously characterized in vivo. Here we describe ...
Exploiting metabolic vulnerabilities for personalized therapy in acute myeloid leukemia | BMC Biology | Full Text
Direct interaction of the mitochondrial membrane protein carnitine palmitoyltransferase I with Bcl-2. Biochem Biophys Res ... Clinical safety and activity of AG-120, a first-in-class, potent inhibitor of the IDH1 mutant protein, in a phase 1 study of ... Protein synthesis is resistant to rapamycin and constitutes a promising therapeutic target in acute myeloid leukemia. Blood. ... BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells. Cell Stem ...
A structural viral mimic of prosurvival Bcl-2: a pivotal role for sequestering proapoptotic Bax and Bak
For example, adenoviruses and some gamma-herpesviruses express homologs of prosurvival Bcl-2 to subvert the host's apoptotic ... Many viruses express antiapoptotic proteins to counter host defense mechanisms that would otherwise trigger the rapid clearance ... These findings expand the family of protein sequences that act like Bcl-2 to block apoptosis and support the conclusion that ... A structural viral mimic of prosurvival Bcl-2: a pivotal role for sequestering proapoptotic Bax and Bak Mol Cell. 2007 Mar 23; ...
A structural viral mimic of prosurvival Bcl-2: a pivotal role for sequestering proapoptotic Bax and Bak
For example, adenoviruses and some gamma-herpesviruses express homologs of prosurvival Bcl-2 to subvert the hosts apoptotic ... Many viruses express antiapoptotic proteins to counter host defense mechanisms that would otherwise trigger the rapid clearance ... These findings expand the family of protein sequences that act like Bcl-2 to block apoptosis and support the conclusion that ... A structural viral mimic of prosurvival Bcl-2: a pivotal role for sequestering proapoptotic Bax and Bak Mol Cell. 2007 Mar 23; ...
Bcl-2 homologous antagonist killer - Wikipedia
This protein also interacts with the tumor suppressor P53 after exposure to cell stress. BAK1 is a pro-apoptotic Bcl-2 protein ... "Entrez Gene: BAK1 BCL2-antagonist/killer 1". Westphal D, Kluck RM, Dewson G (February 2014). "Building blocks of the apoptotic ... The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act ... two proteins of the mitochondrial protein sorting and assembly machinery, are essential for Bak activation during TNF alpha ...
Induction of Androgen Receptor-Dependent Apoptosis in Prostate Cancer Cells by the Retinoblastoma Protein - Fingerprint
-...
Induction of Androgen Receptor-Dependent Apoptosis in Prostate Cancer Cells by the Retinoblastoma Protein. ... bcl-2 Homologous Antagonist-Killer Protein 11% * Mitochondria 11% * Genetic Suppression 10% ... Induction of Androgen Receptor-Dependent Apoptosis in Prostate Cancer Cells by the Retinoblastoma Protein. Together they form ...
Flavonoids isolated from Citrus platymamma induced G2/M cell cycle arrest and apoptosis in A549 human lung cancer cells
... associated X protein/Bcl‑extra large ratio in A549 cells. These findings suggest that FCP induced G2/M arrest and apoptosis of ... Slee EA, Adrain C and Martin SJ: Serial killers: ordering caspase activation events in apoptosis. Cell Death Differ. 6:1067- ... The protein content was quantified using a Bradford assay (Bio-Rad Laboratories, Inc.). Proteins were separated by 12% sodium ... whereas the expression of the proapoptotic Bax protein was unchanged, and the ratio of Bax/Bcl-xL was dose-dependently ...
فاکتور رشد اندوتلیال عروقی (VEGF) | دانلود مقالات ISI فاکتور رشد اندوتلیال عروقی (VEGF) | 4434 مقاله انگلیسی + ترجمه فارسی
Keywords: فاکتور رشد اندوتلیال عروقی (VEGF); AP-1; activator protein-1; Bax; Bcl-2-associated X protein; Bcl-2; B cell lymphoma ... C/EBP-homologous protein 10; DNA; dezoxiribonucleic acid; FITC; fluorescein isothiocyanate; GAPDH; (Glyceraldehyde 3-phosphate ... Keywords: فاکتور رشد اندوتلیال عروقی (VEGF); AMPK; AMP-activated protein kinase; ARF6; ADP-ribosylation factor 6; AKT; protein ... autophagy protein; BAK; Bcl 2 homologous antagonist/killer; BAX; Bcl-2 associated -X protein; Bcl-2; B- ...
Mitochondrial double-stranded RNA triggers antiviral signalling in humans. - MRC Weatherall Institute of Molecular Medicine
2. However, to our knowledge, mitochondrial double-stranded RNA has not been previously characterized in vivo. Here we describe ... bcl-2 Homologous Antagonist-Killer Protein, bcl-2-Associated X Protein ... 2. However, to our knowledge, mitochondrial double-stranded RNA has not been previously characterized in vivo. Here we describe ...
mRNA by PhaRNA - mRNA Products | Next Generation RNA Technologies
Fas-associated protein with death domatin (FADD), Bcl-2 homologous antagonist killer (BAK), Bcl-2 associated X protein (BAX) ... protein kinase C (PKC), protein kinase R (PKR) and toll-like receptors (TLRs). Accordingly, family members of the innate immune ... Collectively, fluorescent reporter proteins are commonly used in biological studies to image cellular compartments, whole cells ... Among these transcription factors are a family of genes known as Paired box (PAX). PAX proteins are essential in early ...
Chinese Journal of Physiology : Table of Contents
... homologous antagonist killer (Bak), BCL-2-associated X protein (Bax), and cytochrome c at both the mRNA and protein levels were ... and MCP-1 protein expression, increase IκB protein expression in HPASMCs. According to what we observed, this study indicated ... and increased cell cycle inhibitor proteins p21. Besides, ASE decreased the total protein level of epidermal growth factor ... At the cellular and molecular levels, we found that 18β-GA could significantly reduce the accumulation of misfolded protein in ...
Carcinoma, endometrioid - pathology
... bcl-X protein - metabolism. Charakt. formalna: Zagraniczny artyku Charakt. merytoryczna: Praca oryginalna. J zyk publikacji: ... Tytu orygina u: Coexistence of homologous-type cervical carcinosarcoma with endometrioid-type G1 endometrial cancer: a case ... bcl-X protein - metabolism. Charakt. formalna: Zagraniczny artyku Charakt. merytoryczna: Praca oryginalna. J zyk publikacji: ... bcl-X protein - metabolism. Charakt. formalna: Zagraniczny artyku Charakt. merytoryczna: Praca oryginalna. J zyk publikacji: ...
bcl-Associated Death Protein | Colorado PROFILES
bcl2-Antagonist of Cell Death Protein. *bcl2 Antagonist of Cell Death Protein ... "bcl-Associated Death Protein" by people in this website by year, and whether "bcl-Associated Death Protein" was a major or ... A pro-apoptotic protein and member of the Bcl-2 protein family that is regulated by PHOSPHORYLATION. Unphosphorylated Bad ... "bcl-Associated Death Protein" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ...
Exploiting metabolic vulnerabilities for personalized therapy in acute myeloid leukemia | BMC Biology | Full Text
Direct interaction of the mitochondrial membrane protein carnitine palmitoyltransferase I with Bcl-2. Biochem Biophys Res ... Clinical safety and activity of AG-120, a first-in-class, potent inhibitor of the IDH1 mutant protein, in a phase 1 study of ... Protein synthesis is resistant to rapamycin and constitutes a promising therapeutic target in acute myeloid leukemia. Blood. ... BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells. Cell Stem ...
Hormone Research
... bcl-X protein - metabolism ; Proto-oncogene proteins c-bcl-2 - metabolism ; Blotting, Western. Charakt. formalna: Zagraniczne ... Angielskie s owa kluczowe: Graves disease - pathology ; Goiter, nodular - pathology ; Proto-oncogene proteins c-bcl-2 - ... Tytu orygina u: Identification of proapoptotic (BAK,BAX) and antiapoptotic (BCL-xL), BCL-2) proteins in thyrocytes from ... Proto-oncogene proteins c-bcl-2 - biosynthesis ; Thyrotropin - blood ; Thyroxine - blood ; Triiodothyronine - blood. Charakt. ...
Dr Girish Patel - People - Cardiff University
Expression of WAVEs, the WASP (Wiskott-Aldrich syndrome protein) family of verprolin homologous proteins in human wound tissues ... The role of Bik1 (BCL-2 interaction killer) in wound healing [Abstract]. Wound Repair and Regeneration 18(6), pp. A92. (10.1111 ... for resistance and recurrence after conventional chemotherapy and also the recently introduced smoothened antagonists. ... Expression of WAVEs, the WASP (Wiskott-Aldrich syndrome protein) family of verprolin homologous proteins in human wound tissues ...
An integrative analysis of cellular contexts, miRNAs and mRNAs reveals network clusters associated with antiestrogen-resistant...
... protein-coding genes corresponding to TFs (from TransmiR), and signaling proteins (from TransmiR). The triangle denotes the ... Guirouilh-Barbat JK, Wilhelm T, Lopez BS: AKT1/BRCA1 in the control of homologous recombination and genetic stability: the ... MicroRNA-125b confers the resistance of breast cancer cells to paclitaxel through suppression of pro-apoptotic Bcl-2 antagonist ... killer 1 (Bak1) expression. J Biol Chem. 2010, 285: 21496-21507. 10.1074/jbc.M109.083337. ...
Apoptosis - WikiProjectMed
Many viruses encode proteins that can inhibit apoptosis.[104] Several viruses encode viral homologs of Bcl-2. These homologs ... such as Natural Killer and cytotoxic T cells) that then induce the infected cell to undergo apoptosis.[99] ... The adenovirus E1B-55K protein and the hepatitis B virus HBx protein are examples of viral proteins that can perform such a ... these inhibitory proteins target retinoblastoma tumor-suppressing proteins.[84] These tumor-suppressing proteins regulate the ...
View source for Static popular pages list - wikidoc
Protein metabolism ]] #[[Prozone ]] #[[Robert W. Holley ]] #[[Röntgen equivalent man ]] #[[SUMO protein ]] #[[ ... Homologous series ]] #[[ICD-10 Chapter K ]] #[[Cementum ]] #[[Chronic stable angina historical perspective ]] #[[Cluster of ... Antagonist (muscle) ]] #[[Anti-ganglioside antibodies ]] #[[Arcuate vein ]] #[[Arene substitution patterns ]] #[[ATC code H ... Natural Killer T cell ]] #[[Dichloromethane ]] #[[Extensor hallucis longus muscle ]] #[[Exudate ]] #[[Failure to thrive ...
Division of Oncology - Research output
- Research Profiles at Washington University School of Medicine
Ajuba, a novel LIM protein, interacts with Grb2, augments mitogen- activated protein kinase activity in fibroblasts, and ... Natural killer cells from HIV-1+ patients produce C-C chemokines and inhibit HIV-1 infection. Fehniger, T. A., Herbein, G., Yu ... bcl-2 gene rearrangement determined by PCR as a mean to detect minimal residual disease in malignant lymphomas. Xiang, Z. F., ... Peptidomimetic antagonist of the integrin α(v)β3 inhibits leydig cell tumor growth and the development of hypercalcemia of ...
Rat BAK1(BCL2 Antagonist/Killer 1) ELISA Kit - Rat BAK1(BCL2 Antagonist/Killer 1) ELISA Kit Exporter, Importer, Manufacturer,...
BCL2 Antagonist/Killer 1) ELISA Kit based in Delhi, India ... Rat BAK1(BCL2 Antagonist/Killer 1) ELISA Kit. *Rat BAX(BCL-2 ... Rat SP-A1(Pulmonary surfactant-associated protein A1) ELISA Kit. *Rat SP-A1(Pulmonary surfactant-associated protein A1) ELISA ... Rat BAK1(BCL2 Antagonist/Killer 1) ELISA Kit Synonyms:BAK, BAK-LIKE, BCL2L7, CDN1, Bcl-2 Homologous Antagonist/Killer. Intended ... Get a price quote for Rat BAK1(BCL2 Antagonist/Killer 1) ELISA Kit ...
CARD R-BASE
Sperm postacrosomal WW domain-binding protein is not required for mouse egg activation. C/EBP homologous protein deficiency ... Bcl-xL Displays Restricted Distribution during T Cell Developement and Inhibits Multiple Forms of Apoptosis but Not Clonal ... T Cell Receptor Antagonist Peptides Induce Positive Selection. Tissue-specific knockout of the mouse Pig-a gene reveals ... Reversible Defects in Natural Killer and Memory CD8 T Cell Lineages in Interleukin 15-deficient Mice. Differential T Cell ...
E4BP4 facilitates glucocorticoid-evoked apoptosis of human leukemic CEM cells via upregulation of Bim
BH3-only proteins of the Bcl-2 family, Bim and Puma, are required for the initiation of apoptosis by multiple stimuli, ... To confirm that Dex-dependent cell death and E4BP4 and Bim upregulation are dependent on GR, the effects of the GR antagonist ... E4BP4 has been shown to induce differentiation in monocyte-macrophages [50], to drive natural killer cell lineage development [ ... The mouse and human E4BP4 genes are highly homologous, with 79% nucleotide sequence identity in the coding region. The two ...
mRNA vaccines - a new era in vaccinology | Nature Reviews Drug Discovery
B cell lymphoma 6 protein (BCL-6), was identified183,184,185. TFH cells represent a specialized subset of CD4+ T cells that ... Self-amplifying mRNA vaccines expressing multiple conserved influenza antigens confer protection against homologous and ... antagonist increased the cytolytic capacity of CD8+ T cells and modestly delayed tumour growth in OVA-expressing lymphoma or ... Tumor associated antigen and interleukin-12 mRNA transfected dendritic cells enhance effector function of natural killer cells ...
Nerve Growth factor IB | 4A. Nerve growth factor IB-like receptors | IUPHAR/BPS Guide to PHARMACOLOGY
Martens C, Bilodeau S, Maira M, Gauthier Y, Drouin J. (2005) Protein-protein interactions and transcriptional antagonism ... Antagonist Comments. Based on alignment with the related NR4A subfamilly members and on 3D structure analysis of the LBD, NR4A1 ... 2004) Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3. Cell, 116 (4): 527-40 ... 1990) A human early response gene homologous to murine nur77 and rat NGFI-B, and related to the nuclear receptor superfamily. ...
other families extract | Natural Compounds | MedChemExpress
PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein ( ... Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). ... Natural Killer Group 2, Member D (NKG2D). *Prostate Specific Membrane Antigen. *CRACC/SLAMF7 ... Viral Proteins. Biotinylated Proteins. Fluorescent-labeled Proteins. GMP-grade Proteins. Animal-free Recombinant Proteins. ...
Studies on IKK | Interstellar Blends | Activate Your Super Powers!
antagonist blocks histamine-induced proinflammatory cytokine production through inhibition of Ca2+-dependent protein kinase C, ... Regulation of expression of Bcl-3 proto-oncogene by IKK ϵ. *Regulation of I-kappa-B kinase (IKK) Pathway by CARMA 1• Bcl-10• ... IKK-i and TBK-1 are Enzymatically Distinct from the Homologous Enzyme IKK-2 COMPARATIVE ANALYSIS OF RECOMBINANT HUMAN IKK-i, ... Deficient natural killer cell cytotoxicity in patients with IKK-γ/NEMO mutations ...
RegenerativeMedicine.net - Article Archives
... promotes cancer metastasis through resistance to anoikis and increased invasiveness Co-targeting of BAX and BCL-XL proteins ... Reparative effects of interleukin-1 receptor antagonist in young and aged/co-morbid rodents after cerebral ischemia Epithelial- ... pylori infection in a pig model is dominated by Th1 and cytotoxic CD8+ T cell responses Epigenetic control of natural killer ... microtissue and its application for adverse drug reaction assay Non-catalytic roles for XPG with BRCA1 and BRCA2 in homologous ...
Polymerase Chain Reaction | [email protected]
Protein fabrication automation. * Protein isoforms encoded by the pX region of human T-cell leukemia/lymphotropic virus type I. ... Frequent detection of bcl-2/JH translocations in human blood and organ samples by a quantitative polymerase chain reaction ... Identification and mapping of type 1 neurofibromatosis (NF1) homologous loci. * Identification of Aedes aegypti and its ... cDNA cloning of an intracellular form of the human interleukin 1 receptor antagonist associated with epithelium. ...
oncologischonderzoek.nl - Nieuws
... protein flare C SCANS studie C-486 C-ALCL C-ETACs as hallmarks of cancer C-ion RT C-reactive protein C-reactive protein ... BBD-BC BCBM BCC BCCs BCCSS BCG BCG vaccination in childhood BCG-unresponsive non-muscle-invasive bladder cancer BCIN+ BCIS Bcl- ... agonists versus GnRH antagonists CVD risk factors CVD risk factors and colorectal cancer CVEs CVSS-studie CXB CXCL8-CXCR1 2 ... levels cytokine-induced killer cell therapy cytokines cytology testing cytoreductive surgery Cytosponge-trefoil factor 3 D-2- ...
Apoptosis-regulato1
- Natural substances exert their anti-cancer activity by modulating cell cycle progression and inducing apoptosis-regulatory proteins ( 8 , 9 ). (spandidos-publications.com)
Antiapoptotic2
- Many viruses express antiapoptotic proteins to counter host defense mechanisms that would otherwise trigger the rapid clearance of infected cells. (nih.gov)
- In addition, B-cell lymphoma (Bcl)-2 family proteins are important for apoptosis regulation, which could be either proapoptotic, such as Bcl-2-associated X protein (Bax) or Bcl-2 homologous antagonist/killer, or antiapoptotic, such as Bcl-2 and Bcl-extra large (Bcl-xL) ( 13 ). (spandidos-publications.com)
CHOP1
- PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells. (medchemexpress.com)
Mitochondria1
- This protein localizes to mitochondria, and functions to induce apoptosis. (wikipedia.org)
Inhibits4
- Unphosphorylated Bad protein inhibits the activity of BCL-XL PROTEIN. (ucdenver.edu)
- Sulindac sulfide inhibits epidermal growth factor-induced phosphorylation of extracellular-regulated kinase 1/2 and Bad in human colon cancer cells. (ucdenver.edu)
- Sulforaphane increases tumor suppressor protein transcription and inhibits histone deacetylase activity. (medchemexpress.com)
- Epigallocatechin Gallate inhibits glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) activity. (medchemexpress.com)
Inhibit2
- Novel benzylidene-thiazolidine-2,4-diones inhibit Pim protein kinase activity and induce cell cycle arrest in leukemia and prostate cancer cells. (ucdenver.edu)
- Some factors like Fas receptors and caspases promote apoptosis, while some members of the Bcl-2 family of proteins inhibit apoptosis. (mdwiki.org)
Caspases2
- [5] Both pathways induce cell death by activating caspases , which are proteases , or enzymes that degrade proteins. (mdwiki.org)
- The two pathways both activate initiator caspases, which then activate executioner caspases, which then kill the cell by degrading proteins indiscriminately. (mdwiki.org)
BAK14
- Bcl-2 homologous antagonist/killer is a protein that in humans is encoded by the BAK1 gene on chromosome 6. (wikipedia.org)
- BAK1 is a pro-apoptotic Bcl-2 protein containing four Bcl-2 homology (BH) domains: BH1, BH2, BH3, and BH4. (wikipedia.org)
- As a member of the BCL2 protein family, BAK1 functions as a pro-apoptotic regulator involved in a wide variety of cellular activities. (wikipedia.org)
- The inactive form of BAK1 is maintained by the protein's interactions with VDAC2, Mtx2, and other anti-apoptotic members of the BCL2 protein family. (wikipedia.org)
BCL22
- The protein encoded by this gene belongs to the BCL2 protein family. (wikipedia.org)
- This occurred in 1988 when it was shown that BCL2, the gene responsible for follicular lymphoma, encoded a protein that inhibited cell death. (mdwiki.org)
Tumor2
- This protein also interacts with the tumor suppressor P53 after exposure to cell stress. (wikipedia.org)
- This mainly results from the high frequency of distant relapses caused by tumor regrowth initiated by chemoresistant leukemic clones after chemotherapy [ 2 , 3 ]. (biomedcentral.com)
Gene1
- The first report of the successful use of in vitro transcribed (IVT) mRNA in animals was published in 1990, when reporter gene mRNAs were injected into mice and protein production was detected 5 . (nature.com)
Regulators2
- Comparison of E-cadherin with STAT3 and apoptosis regulators: Bak and Bcl-xL in endometrioid adenocarcinomas of different ER-alpha immunoprofile. (edu.pl)
- Here, we identify Nfat proteins as Sox10 targets and regulators of oligodendroglial differentiation in rodents and humans. (regenerativemedicine.net)
Activation1
- In addition, FCP induced caspase‑3 activation and subsequent PARP cleavage, and increased the B‑cell lymphoma (Bcl)‑2‑associated X protein/Bcl‑extra large ratio in A549 cells. (spandidos-publications.com)
Family4
- These findings expand the family of protein sequences that act like Bcl-2 to block apoptosis and support the conclusion that the prosurvival action of these proteins critically depends on their ability to bind and antagonize Bax and/or Bak. (nih.gov)
- A pro-apoptotic protein and member of the Bcl-2 protein family that is regulated by PHOSPHORYLATION. (ucdenver.edu)
- Neuronal apoptosis induced by selective inhibition of Rac GTPase versus global suppression of Rho family GTPases is mediated by alterations in distinct mitogen-activated protein kinase signaling cascades. (ucdenver.edu)
- Upregulation of the BH3-only member of Bcl-2 family proteins, Bim, has been shown to be essential for GC-evoked apoptosis of leukemic lymphoblasts. (jmolecularsignaling.com)
Molecular1
- On a molecular level, Nfat proteins cooperate with Sox10 to relieve reciprocal repression of Olig2 and Nkx2.2 as precondition for oligodendroglial differentiation and myelination. (regenerativemedicine.net)
Vivo1
- Research has proven that mRNA mimetics have superior translational efficiency than recombinant DNA and, unlike recombinant proteins, can be endogenously modified in vivo. (pharna.com)
Regulation1
- Meshki J, Caino MC, von Burstin VA, Griner E, Kazanietz MG. Regulation of prostate cancer cell survival by protein kinase Cepsilon involves bad phosphorylation and modulation of the TNFalpha/JNK pathway. (ucdenver.edu)
Membrane1
- Protein disulfide isomerase homolog PDILT is required for quality control of sperm membrane protein ADAM3 and male fertility [corrected]. (kumamoto-u.ac.jp)
Phosphorylates1
- Yan B, Zemskova M, Holder S, Chin V, Kraft A, Koskinen PJ, Lilly M. The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death. (ucdenver.edu)
Machinery1
- For example, adenoviruses and some gamma-herpesviruses express homologs of prosurvival Bcl-2 to subvert the host's apoptotic machinery. (nih.gov)
Approaches1
- The growth factors in medical use so far have been produced using recombinant DNA or recombinant protein approaches. (pharna.com)
MRNA2
- Recent improvements in mRNA vaccines act to increase protein translation, modulate innate and adaptive immunogenicity and improve delivery. (nature.com)
- Over the past decade, major technological innovation and research investment have enabled mRNA to become a promising therapeutic tool in the fields of vaccine development and protein replacement therapy. (nature.com)
Transcription2
- Consequently, in mammals, mitochondrial DNA is subjected to bidirectional transcription that generates overlapping transcripts, which are capable of forming long double-stranded RNA structures1,2. (ox.ac.uk)
- Characterization of the murine cytomegalovirus early transcription unit e1 that is induced by immediate-early proteins. (kumamoto-u.ac.jp)
Death4
- bcl-Associated Death Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ucdenver.edu)
- This graph shows the total number of publications written about "bcl-Associated Death Protein" by people in this website by year, and whether "bcl-Associated Death Protein" was a major or minor topic of these publications. (ucdenver.edu)
- Below are the most recent publications written about "bcl-Associated Death Protein" by people in Profiles. (ucdenver.edu)
- Death-effector domain-containing protein DEDD is an inhibitor of mitotic Cdk1/cyclin B1. (kumamoto-u.ac.jp)
Domain4
- A hydrophobic groove formed along the C-terminal of α2 to the N-terminal of α5, and some residues from α8, binds the BH3 domain of other BCL-2 proteins in its active form. (wikipedia.org)
- Nur77 binding induces a Bcl-2 conformational change that exposes its BH3 domain, resulting in conversion of Bcl-2 from a protector to a killer. (guidetopharmacology.org)
- NR4A1 seems to interact with SRC-2 via its a/B domain. (guidetopharmacology.org)
- SRC-2 modulates the activity of the N-terminal AF-1 domain. (guidetopharmacology.org)
Growth1
- In cardiovascular research, growth factors such as VEGF have been used as ligands to stimulate angiogenesis whereas in cancer research inhibition of dysregulated growth factor receptors is the premise for several clinically used drugs including inhibitors of VEGF receptor (VEGFR), EGR receptor 1 (HER1), and EGF receptor 2 (HER2). (pharna.com)
Active1
- NFAT proteins are also detected in human oligodendrocytes, downregulated in active multiple sclerosis lesions and thus likely relevant in demyelinating disease. (regenerativemedicine.net)
Primary1
- Analysis of its three-dimensional structure reveals that despite lacking any primary sequence similarity to Bcl-2, it adopts a virtually identical protein fold. (nih.gov)
Type1
- Coexistence of homologous-type cervical carcinosarcoma with endometrioid-type G1 endometrial cancer: a case report with an immunohistochemical study. (edu.pl)