Bcg vaccine. Medical search

An active immunizing agent and a viable avirulent attenuated strain of Mycobacterium tuberculosis, var. bovis, which confers immunity to mycobacterial infections. It is used also in immunotherapy of neoplasms due to its stimulation of antibodies and non-specific immunity.

The bovine variety of the tubercle bacillus. It is called also Mycobacterium tuberculosis var. bovis.

Suspensions of killed or attenuated microorganisms (bacteria, viruses, fungi, protozoa), antigenic proteins, synthetic constructs, or other bio-molecular derivatives, administered for the prevention, amelioration, or treatment of infectious and other diseases.

Vaccines or candidate vaccines used to prevent or treat TUBERCULOSIS.

Small synthetic peptides that mimic surface antigens of pathogens and are immunogenic, or vaccines manufactured with the aid of recombinant DNA techniques. The latter vaccines may also be whole viruses whose nucleic acids have been modified.

Vaccines in which the infectious microbial nucleic acid components have been destroyed by chemical or physical treatment (e.g., formalin, beta-propiolactone, gamma radiation) without affecting the antigenicity or immunogenicity of the viral coat or bacterial outer membrane proteins.

Administration of vaccines to stimulate the host's immune response. This includes any preparation intended for active immunological prophylaxis.

Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM.

Suspensions of attenuated or killed viruses administered for the prevention or treatment of infectious viral disease.

One of several skin tests to determine past or present tuberculosis infection. A purified protein derivative of the tubercle bacilli, called tuberculin, is introduced into the skin by scratch, puncture, or interdermal injection.

Recombinant DNA vectors encoding antigens administered for the prevention or treatment of disease. The host cells take up the DNA, express the antigen, and present it to the immune system in a manner similar to that which would occur during natural infection. This induces humoral and cellular immune responses against the encoded antigens. The vector is called naked DNA because there is no need for complex formulations or delivery agents; the plasmid is injected in saline or other buffers.

Two or more vaccines in a single dosage form.

Suspensions of attenuated or killed bacteria administered for the prevention or treatment of infectious bacterial disease.

A species of gram-positive, aerobic bacteria that produces TUBERCULOSIS in humans, other primates, CATTLE; DOGS; and some other animals which have contact with humans. Growth tends to be in serpentine, cordlike masses in which the bacilli show a parallel orientation.

A system of physical units in which the fundamental quantities are length, time, mass, electric current, temperature, luminous intensity, and amount of substance, and the corresponding units are the meter, second, kilogram, ampere, kelvin, candela, and mole. The system has been given official status and recommended for universal use by the General Conference on Weights and Measures.

Vaccines or candidate vaccines containing inactivated HIV or some of its component antigens and designed to prevent or treat AIDS. Some vaccines containing antigens are recombinantly produced.

A republic in western Africa, south of SENEGAL and west of GUINEA. Its capital is Bissau.

Vaccines consisting of one or more antigens that stimulate a strong immune response. They are purified from microorganisms or produced by recombinant DNA techniques, or they can be chemically synthesized peptides.

Semisynthetic vaccines consisting of polysaccharide antigens from microorganisms attached to protein carrier molecules. The carrier protein is recognized by macrophages and T-cells thus enhancing immunity. Conjugate vaccines induce antibody formation in people not responsive to polysaccharide alone, induce higher levels of antibody, and show a booster response on repeated injection.

Any immunization following a primary immunization and involving exposure to the same or a closely related antigen.

MYCOBACTERIUM infections of the lung.

An acute form of TUBERCULOSIS in which minute tubercles are formed in a number of organs of the body due to dissemination of the bacilli through the blood stream.

Inflammation of the lymph nodes.

A form of bacterial meningitis caused by MYCOBACTERIUM TUBERCULOSIS or rarely MYCOBACTERIUM BOVIS. The organism seeds the meninges and forms microtuberculomas which subsequently rupture. The clinical course tends to be subacute, with progressions occurring over a period of several days or longer. Headache and meningeal irritation may be followed by SEIZURES, cranial neuropathies, focal neurologic deficits, somnolence, and eventually COMA. The illness may occur in immunocompetent individuals or as an OPPORTUNISTIC INFECTION in the ACQUIRED IMMUNODEFICIENCY SYNDROME and other immunodeficiency syndromes. (From Adams et al., Principles of Neurology, 6th ed, pp717-9)

Vaccines made from antigens arising from any of the four strains of Plasmodium which cause malaria in humans, or from P. berghei which causes malaria in rodents.

Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.

Vaccines or candidate vaccines used to prevent PAPILLOMAVIRUS INFECTIONS. Human vaccines are intended to reduce the incidence of UTERINE CERVICAL NEOPLASMS, so they are sometimes considered a type of CANCER VACCINES. They are often composed of CAPSID PROTEINS, especially L1 protein, from various types of ALPHAPAPILLOMAVIRUS.

Substances elaborated by bacteria that have antigenic activity.

Vaccines or candidate vaccines used to prevent infection with NEISSERIA MENINGITIDIS.

A protein extracted from boiled culture of tubercle bacilli (MYCOBACTERIUM TUBERCULOSIS). It is used in the tuberculin skin test (TUBERCULIN TEST) for the diagnosis of tuberculosis infection in asymptomatic persons.

An increased reactivity to specific antigens mediated not by antibodies but by cells.

Live vaccines prepared from microorganisms which have undergone physical adaptation (e.g., by radiation or temperature conditioning) or serial passage in laboratory animal hosts or infected tissue/cell cultures, in order to produce avirulent mutant strains capable of inducing protective immunity.

Vaccines or candidate vaccines containing inactivated hepatitis B or some of its component antigens and designed to prevent hepatitis B. Some vaccines may be recombinantly produced.

A live attenuated virus vaccine of chick embryo origin, used for routine immunization of children and for immunization of adolescents and adults who have not had measles or been immunized with live measles vaccine and have no serum antibodies against measles. Children are usually immunized with measles-mumps-rubella combination vaccine. (From Dorland, 28th ed)

A suspension of killed Bordetella pertussis organisms, used for immunization against pertussis (WHOOPING COUGH). It is generally used in a mixture with diphtheria and tetanus toxoids (DTP). There is an acellular pertussis vaccine prepared from the purified antigenic components of Bordetella pertussis, which causes fewer adverse reactions than whole-cell vaccine and, like the whole-cell vaccine, is generally used in a mixture with diphtheria and tetanus toxoids. (From Dorland, 28th ed)

Vaccines or candidate vaccines containing antigenic polysaccharides from Haemophilus influenzae and designed to prevent infection. The vaccine can contain the polysaccharides alone or more frequently polysaccharides conjugated to carrier molecules. It is also seen as a combined vaccine with diphtheria-tetanus-pertussis vaccine.

The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.

A suspension of formalin-inactivated poliovirus grown in monkey kidney cell tissue culture and used to prevent POLIOMYELITIS.

Vaccines or candidate vaccines used to prevent and treat RABIES. The inactivated virus vaccine is used for preexposure immunization to persons at high risk of exposure, and in conjunction with rabies immunoglobulin, for postexposure prophylaxis.

Vaccines or candidate vaccines used to prevent infection with ROTAVIRUS.

A chronic granulomatous infection caused by MYCOBACTERIUM LEPRAE. The granulomatous lesions are manifested in the skin, the mucous membranes, and the peripheral nerves. Two polar or principal types are lepromatous and tuberculoid.

Vaccines or candidate vaccines used to prevent infection with VIBRIO CHOLERAE. The original cholera vaccine consisted of killed bacteria, but other kinds of vaccines now exist.

A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.

Manifestations of the immune response which are mediated by antigen-sensitized T-lymphocytes via lymphokines or direct cytotoxicity. This takes place in the absence of circulating antibody or where antibody plays a subordinate role.

An iron-binding protein that was originally characterized as a milk protein. It is widely distributed in secretory fluids and is found in the neutrophilic granules of LEUKOCYTES. The N-terminal part of lactoferrin possesses a serine protease which functions to inactivate the TYPE III SECRETION SYSTEM used by bacteria to export virulence proteins for host cell invasion.

A live VACCINIA VIRUS vaccine of calf lymph or chick embryo origin, used for immunization against smallpox. It is now recommended only for laboratory workers exposed to smallpox virus. Certain countries continue to vaccinate those in the military service. Complications that result from smallpox vaccination include vaccinia, secondary bacterial infections, and encephalomyelitis. (Dorland, 28th ed)

Vaccines used to prevent TYPHOID FEVER and/or PARATYPHOID FEVER which are caused by various species of SALMONELLA. Attenuated, subunit, and inactivated forms of the vaccines exist.

A vaccine consisting of DIPHTHERIA TOXOID; TETANUS TOXOID; and whole-cell PERTUSSIS VACCINE. The vaccine protects against diphtheria, tetanus, and whooping cough.

Immunoglobulins produced in response to VIRAL ANTIGENS.

An encapsulated lymphatic organ through which venous blood filters.

A live, attenuated varicella virus vaccine used for immunization against chickenpox. It is recommended for children between the ages of 12 months and 13 years.

Schedule giving optimum times usually for primary and/or secondary immunization.

An infant during the first month after birth.

Vaccines used to prevent infection by MUMPS VIRUS. Best known is the live attenuated virus vaccine of chick embryo origin, used for routine immunization of children and for immunization of adolescents and adults who have not had mumps or been immunized with live mumps vaccine. Children are usually immunized with measles-mumps-rubella combination vaccine.

Proteins found in any species of bacterium.

Vaccines or candidate vaccines used to prevent infection with hepatitis A virus (HEPATOVIRUS).

A combined vaccine used to prevent MEASLES; MUMPS; and RUBELLA.

Vaccines or candidate vaccines used to prevent STREPTOCOCCAL INFECTIONS.

Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).

Vaccines or candidate vaccines used to prevent ANTHRAX.

Vaccines or candidate vaccines used to prevent infection with DENGUE VIRUS. These include live-attenuated, subunit, DNA, and inactivated vaccines.

Vaccines using VIROSOMES as the antigen delivery system that stimulates the desired immune response.

Immunoglobulins produced in a response to BACTERIAL ANTIGENS.

The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.

Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.

Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.

A live vaccine containing attenuated poliovirus, types I, II, and III, grown in monkey kidney cell tissue culture, used for routine immunization of children against polio. This vaccine induces long-lasting intestinal and humoral immunity. Killed vaccine induces only humoral immunity. Oral poliovirus vaccine should not be administered to immunocompromised individuals or their household contacts. (Dorland, 28th ed)

Any vaccine raised against any virus or viral derivative that causes hepatitis.

Vaccine used to prevent YELLOW FEVER. It consists of a live attenuated 17D strain of the YELLOW FEVER VIRUS.

A suspension of killed Yersinia pestis used for immunizing people in enzootic plague areas.

Suspensions of attenuated or killed fungi administered for the prevention or treatment of infectious fungal disease.

A live attenuated virus vaccine of duck embryo or human diploid cell tissue culture origin, used for routine immunization of children and for immunization of nonpregnant adolescent and adult females of childbearing age who are unimmunized and do not have serum antibodies to rubella. Children are usually immunized with measles-mumps-rubella combination vaccine. (Dorland, 28th ed)

The genetic complement of a BACTERIA as represented in its DNA.

Vaccines that are produced by using only the antigenic part of the disease causing organism. They often require a "booster" every few years to maintain their effectiveness.

Vaccines or candidate vaccines designed to prevent SAIDS; (SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME); and containing inactivated SIMIAN IMMUNODEFICIENCY VIRUS or type D retroviruses or some of their component antigens.

Vaccines or candidate vaccines used to prevent infection with SALMONELLA. This includes vaccines used to prevent TYPHOID FEVER or PARATYPHOID FEVER; (TYPHOID-PARATYPHOID VACCINES), and vaccines used to prevent nontyphoid salmonellosis.

Vaccines using supra-molecular structures composed of multiple copies of recombinantly expressed viral structural proteins. They are often antigentically indistinguishable from the virus from which they were derived.

Vaccines or candidate vaccines used to prevent EBOLA HEMORRHAGIC FEVER.

An acute viral infection in humans involving the respiratory tract. It is marked by inflammation of the NASAL MUCOSA; the PHARYNX; and conjunctiva, and by headache and severe, often generalized, myalgia.

Elements of limited time intervals, contributing to particular results or situations.

Organized services to administer immunization procedures in the prevention of various diseases. The programs are made available over a wide range of sites: schools, hospitals, public health agencies, voluntary health agencies, etc. They are administered to an equally wide range of population groups or on various administrative levels: community, municipal, state, national, international.

Antibodies that reduce or abolish some biological activity of a soluble antigen or infectious agent, usually a virus.

Combined vaccines consisting of DIPHTHERIA TOXOID; TETANUS TOXOID; and an acellular form of PERTUSSIS VACCINE. At least five different purified antigens of B. pertussis have been used in various combinations in these vaccines.

The forcing into the skin of liquid medication, nutrient, or other fluid through a hollow needle, piercing the top skin layer.

Vaccines or candidate vaccines used to prevent infection with CYTOMEGALOVIRUS.

Delivery of medications through the nasal mucosa.

The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.

The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.

Forceful administration into a muscle of liquid medication, nutrient, or other fluid through a hollow needle piercing the muscle and any tissue covering it.

A combined vaccine used to prevent infection with diphtheria and tetanus toxoid. This is used in place of DTP vaccine (DIPHTHERIA-TETANUS-PERTUSSIS VACCINE) when PERTUSSIS VACCINE is contraindicated.

Vaccines used to prevent POLIOMYELITIS. They include inactivated (POLIOVIRUS VACCINE, INACTIVATED) and oral vaccines (POLIOVIRUS VACCINE, ORAL).

Vaccines or candidate vaccines used to prevent or treat both enterotoxigenic and enteropathogenic Escherichia coli infections.

Vaccines or candidate vaccines used to prevent infection with WEST NILE VIRUS.

Advances in the biological therapy and gene therapy of malignant disease. (1/1802)

Biological and gene therapy of cancer have become important components of clinical cancer research. Advances in this area are based on evidence for the presence of tumor antigens, antitumor immune responses, evasion of host control by tumors, and the recognition of host defense failure in cancer patients. These mechanisms are being corrected or exploited in the development of biological and gene therapy. Over the last decade, 9 biological therapies have received Food and Drug Administration approval, and another 12 appear promising and will likely be approved in the next few years. Our approach to gene therapy has been to allogenize tumors by the direct intratumoral injection of HLA-B7/beta2-microglobulin genes as plasmid DNA in a cationic lipid into patients with malignant melanoma. In four Phase I studies, we found a 36% response by the local injected tumor and a 19% systemic antitumor response. In other cancers, gene transfer, expression, and an intratumoral T-cell response were seen, but no clinical response was seen. A variety of follow-up studies with HLA-B7 and other genes are planned. Evasion of host control is now a major target of gene therapy. Strategies to overcome this include up-regulation of MHC and introduction of cell adhesion molecules into tumor cells, suppression of transforming growth factor and interleukin 10 production by tumor cells, and blockade of the fas ligand-fas interaction between tumor cells and attacking lymphocytes. With these approaches, it seems likely that gene therapy may become the fifth major modality of cancer treatment in the next decade. (+info)

Characterization of the culture filtrate-specific cytotoxic T lymphocyte response induced by Bacillus Calmette-Guerin vaccination in H-2b mice. (2/1802)

Although CD8+ T cells are supposed to play an important role in protective immunity to mycobacteria, cytotoxic T lymphocyte (CTL) responses in this infection remain poorly characterized. We previously demonstrated that bacillus Calmette-Guerin (BCG) immunization of H-2b mice induced CTL able to recognize and kill macrophages incubated with proteins from mycobacterial culture supernatant [culture filtrate (CF) antigens]. In the present study, we have further characterized the lytic activity of these CTL and the processing pathway used for the presentation of CF proteins. We show that they use the degranulation pathway (secretion of perforins and granzymes) as the main lytic mechanism of cytotoxicity and also secrete IFN-gamma upon incubation with CF-pulsed macrophages. The in vitro presentation of CF proteins to CTL required a processing step inhibited in the cold but insensitive to Brefeldin A. Transporter-associated protein (TAP)-2-deficient RMA-S cells were efficiently recognized and killed by CF-specific CTL, demonstrating the lack of TAP requirement for this presentation. However, recognition of target cells by CTL was abolished when carried out in the presence of chloroquine. These results indicate that a non-classical MHC class I-processing pathway allows the recognition of a CF protein by CTL in BCG-vaccinated H-2b mice. (+info)

Influences of Kupffer cell stimulation and suppression on immunological liver injury in mice. (3/1802)

AIM: To study the possible involvement of Kupffer cells (KC) in immunological liver injury in mice. METHODS: Liver injury was induced by i.v. injection of Bacillus Calmette-Guerin (BCG) 5 x 10(7) viable bacilli followed by i.v. injection of lipopolysaccharides (LPS) 7.5 micrograms to each mouse. Indian ink and silica were i.v. injected to suppress KC and retinol was given po to stimulate KC in these mice. Plasma alanine aminotransferase (AlaAT), aspatate aminotransferase (AspAT), nitric oxide (NO), and liver tissue were examined. RESULTS: Injection of LPS following BCG injection resulted in a remarkable elevation of plasma NO, AlaAT, and AspAT levels, and severe liver damage. The damages were enhanced by the activation of KC with retinol and reduced by suppression of KC with silica and Indian ink. CONCLUSION: The degree of liver injury induced by BCG + LPS is closely correlated with the status of KC, and NO from KC plays an important role in the pathogenesis of the liver damage in mice. (+info)

Differential protective efficacy of DNA vaccines expressing secreted proteins of Mycobacterium tuberculosis. (4/1802)

The development of more-effective antituberculosis vaccines would assist in the control of the global problem of infection with Mycobacterium tuberculosis. One recently devised vaccination strategy is immunization with DNA plasmids encoding individual microbial genes. Using the genes for the M. tuberculosis secreted proteins MPT64 (23 kDa), Ag85B (30 kDa), and ESAT-6 (6 kDa) as candidate antigens, DNA vaccines were prepared and tested for immunogenicity and protective efficacy in a murine model of aerosolized tuberculosis (TB). Intramuscular immunization with DNA-64 or DNA-85B resulted in the activation of CD4(+) T cells, which produce gamma interferon (IFN-gamma), and high titers of specific immunoglobulin G antibodies. Further, DNA-64 induced major histocompatibility complex class I-restricted CD8(+) cytotoxic T cells. The addition of a eukaryotic leader sequence to mpt64 did not significantly increase the T-cell or antibody response. Each of the three DNA vectors stimulated a significant reduction in the level of M. tuberculosis infection in the lungs of mice challenged 4 weeks after immunization, but not to the levels resulting after immunization with Mycobacterium bovis BCG. The vaccines showed a consistent hierarchy of protection, with the most effective being Ag85B, followed by ESAT-6 and then MPT64. Coimmunization with the three vectors resulted in a greater degree of protection than that induced by any single vector. This protective efficacy was associated with the emergence of IFN-gamma-secreting T cells earlier than in infected animals immunized with a control vector. The efficacy of these DNA vaccines suggests that multisubunit vaccination may contribute to future vaccine strategies against TB. (+info)

Vaccinated mice remain more susceptible to Mycobacterium tuberculosis infection initiated via the respiratory route than via the intravenous route. (5/1802)

Mice given Mycobacterium tuberculosis bacilli via the respiratory route succumbed much sooner to infection than mice given 1,000 times more bacilli via the intravenous route. Vaccination provided increased protection to an M. tuberculosis challenge infection; however, mice infected via the respiratory route remained much more susceptible. (+info)

Skin reaction and antibody responses in guinea-pigs sensitized to human leukaemia cells or their nuclei in combination with Bacillus Calmette-Guerin. (6/1802)

Guinea-pigs sensitized by subcutaneous injection of chronic lymphatic leukaemia (CLL) cells combined with Bacillus Calmette-Guerin (BCG) displayed good skin reacitons 24 and 48 h after challenge with CLL cells. Equally good responses were also demonstrated using nuclei from the leukaemic cells in combination with BCG. These reactions were significantly greater than those produced in the same manner but without BCG. Sera form the animals were examined for the presence of antibodies against CLL cells by cytotoxicity and immunofluorescence techniques. Only samples from guinea-pigs innoculated with CLL cells were found to contain significant antibodies. Histological examination showed that whereas leukaemic cells persisted at the sensitizing injection site leukaemic cell nuclei could not be visualized. It is suggested that because leukaemic cell nuclei in combination with BCG are able to induce good skin reactivity without provoking a vigorous humoral antibody response they may have possible advantages over leukaemic cells when used for immunotherapy. (+info)

The association between CD2+ peripheral blood lymphocyte subsets and the relapse of bladder cancer in prophylactically BCG-treated patients. (7/1802)

We investigated the potential existence of differences in the distribution of T-lymphocyte subsets and in the proliferative response of these CD2+ cells to polyclonal mitogens in patients with transitional cell bladder carcinoma (SBTCC) treated with prophylactic intracavitary instillations of bacillus Calmette-Guerin (BCG) according to their clinical response to this treatment. Before BCG treatment, different subset distribution (CD8+ and CD3+ CD56+), activation antigen expression (CD3+ HLA- DR+) and proliferative response to mitogenic signals were found in CD2+ cells from SBTCC patients prophylactically treated with BCG who remained free of disease or those who had recurrence of tumour. Otherwise, the prophylactic intracavitary BCG instillations in SBTCC patients are associated with a transitory variation of T-lymphocyte subset distribution (CD4 and CD8) and activation antigens expression (CD25). (+info)

Childhood immunization coverage in zone 3 of Dhaka City: the challenge of reaching impoverished households in urban Bangladesh. (8/1802)

A household survey of 651 children aged 12-23 months in Zone 3 of Dhaka City carried out in 1995 revealed that 51% of them had fully completed the series of childhood immunizations. Immunization coverage in slum households was only half that in non-slum households. Apart from residence in a slum household, other characteristics strongly associated with the completion of the entire series of childhood immunizations included the following: educational level of the mother, number of children in the family household, mother's employment status, distance from the nearest immunization site, and number of home visits from family-planning field workers. The findings point to the need to improve childhood immunization promotion and service delivery among slum populations. Two promising strategies for improving coverage are to reduce the number of missed opportunities for immunization promotion during encounters between health workers and clients, and to identify through visits to households those children who need additional immunizations. In the long run, increasing the educational level of women will provide a strong stimulus for improving childhood immunization coverage in the population. (+info)

The main use of BCG is for vaccination against tuberculosis. BCG vaccine can be administered after birth intradermally. BCG ... BCG has been one of the most successful immunotherapies. BCG vaccine has been the "standard of care for patients with bladder ... Previously, the vaccine was also given at ages 8 and 15, although this is no longer common practice. Philippines: BCG vaccine ... Bacillus Calmette-Guérin (BCG) vaccine is a vaccine primarily used against tuberculosis (TB). It is named after its inventors ...

https://en.wikipedia.org/wiki/BCG_vaccine

The BCG vaccine, infant dose, contains between 100,000 and 400,000 colony-forming unit of live attenuated Mycobacterium bovis. ... Meningococcal Group B vaccine, Pneumococcal conjugate vaccine, Hib/MenC vaccine, MMR vaccine, Pre-school Booster, HPV vaccine, ... Vaccine ingredients from the Oxford Vaccine Group. Vaccine Excipient Summary from the Centers for Disease Control and ... The combined Hepatitis A and B vaccine, combined Hepatitis A and typhoid vaccine, and Rabies vaccine are all 1ml. Joint ...

https://en.wikipedia.org/wiki/Vaccine_ingredients

BCG Vaccine , TB , CDC". www.cdc.gov. 11 December 2018. Retrieved 12 November 2019. NEWS, KYODO. "Tuberculosis vaccine drawing ... The BCG vaccine (bacille Calmette-Guerin), which was derived from M. bovis, while effective against childhood and severe forms ... The BCG, according to an article of the Kyodo News (April 14, 2020) titled "Tuberculosis vaccine drawing attention in fight ... To receive this vaccine in the United States, an individual is required to go through a consultation process with an expert in ...

https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis

Luca S, Mihaescu T. (2013). "History of BCG Vaccine". Maedica (Buchar). 8 (1): 53-8. PMC 3749764. PMID 24023600. Nøkleby, Berit ... "Olaf Scheel og Johannes Heimbeck og deres arbeid med BCG-vaksinen". Tidsskr Nor Legeforen. 30 March 2001. Retrieved 1 March ... He is particularly known for introducing the BCG vaccination program against tuberculosis from 1926. Heimbeck was a resistance ...

https://en.wikipedia.org/wiki/Johannes_Heimbeck

The BCG vaccine for tuberculosis was administered to a patient for the first time, in Paris, France, by Benjamin Weill-Halle. U ... "History of BCG Vaccine". Maedica. 8 (1): 53-58. PMC 3749764. PMID 24023600. "July 18, 1921: Babe Ruth's 560-foot blast against ...

https://en.wikipedia.org/wiki/July_1921

Deycke negligently cultivated the BCG vaccine in a laboratory unsuitable for vaccine production and refrained from animal ... As a result of negative public opinion on the BCG vaccine, caused by media reports, the Weimar government de facto stopped all ... From 1929 to 1933, 251 infants in Lübeck, northern Germany, were given three doses of the BCG vaccine against tuberculosis, ... Escobar, Luis E.; Molina-Cruz, Alvaro; Barillas-Mury, Carolina (28 July 2020). "BCG vaccine protection from severe coronavirus ...

https://en.wikipedia.org/wiki/Lübeck_disaster

BCG vaccine was not used in the public health of America, which virtually eliminated tuberculosis without it. BCG vaccine's ... Amid anthrax vaccine's success, Pasteur introduced rabies vaccine (1885), the first human vaccine since Jenner's smallpox ... Brosman, SA (1991). "BCG vaccine in urinary bladder cancer". West J Med. 155 (6): 633. PMC 1003114. PMID 1812634. Gradmann, ... 2006). "Beneficial non-targeted effects of BCG-ethical implications for the coming introduction of new TB vaccines". ...

https://en.wikipedia.org/wiki/Koch–Pasteur_rivalry

"BCG vaccine prevents TB infection in children". GOV.UK. Retrieved 2020-09-09. Abubakar, Ibrahim; Matteelli, Alberto; Vries, ... and on the effects of BCG in TB prevention. He leads the E-DETECT TB project in Europe for the early detection of tuberculosis ...

https://en.wikipedia.org/wiki/Ibrahim_Abubakar

Hawgood, B.J. (August 2007). "Albert Calmette (1863-1933) and Camille Guérin (1872-1961): the C and G of BCG vaccine". Journal ... Togunova, A.I. (1971). "Half a century since the development and practical application of live BCG vaccine (Albert Calmette), ( ... He discovered the Bacillus Calmette-Guérin, an attenuated form of Mycobacterium bovis used in the BCG vaccine against ... Daniel, T.M. (2005). "Leon Charles Albert Calmette and BCG vaccine". The International Journal of Tuberculosis and Lung Disease ...

https://en.wikipedia.org/wiki/Albert_Calmette

The BCG vaccine for tuberculosis is first developed. Richard Oldham argues that the Earth has a molten interior. Construction ...

https://en.wikipedia.org/wiki/1906

The BCG vaccine has limitations, and research to develop new TB vaccines is ongoing. A number of potential candidates are ... Several vaccines are being developed. Intradermal MVA85A vaccine in addition to BCG injection is not effective in preventing ... "Vaccine and Immunizations: TB Vaccine (BCG)". Centers for Disease Control and Prevention. 2011. Archived from the original on ... It was called bacille Calmette-Guérin (BCG). The BCG vaccine was first used on humans in 1921 in France, but achieved ...

https://en.wikipedia.org/wiki/Tuberculosis

... immune enhancing vaccines (gamma globulin, BCG) and antibiotics. Livingston prescribed antibiotics after cross testing them ... During this time, she also began a small test trial of anti-bacterial vaccines made from the body fluids of cancer patients and ... The ACS also challenged the efficacy of Livingston's autogenous vaccine and concluded in its report that there was no ... Livingston's patients also received BCG during the trial---an FDA-approved cancer adjuvant which has been found effective for ...

https://en.wikipedia.org/wiki/Virginia_Livingston

Camille Guérin, co-inventor of the BCG vaccine. Jean Hélion (1904-1987), painter. Jacky Hénin (1960-), politician. Victor Henry ... Albert Calmette co-inventor of the BCG vaccine. Albert Châtelet (1883-1960), professor, mathematician, politician. Louis ...

https://en.wikipedia.org/wiki/University_of_Lille

"Bacille de Calmette-Guérin, or BCG Vaccine for Tuberculosis". ActiveHistory.ca. 2015-03-31. Archived from the original on 2018- ...

https://en.wikipedia.org/wiki/Indian_hospital

The BCG vaccine has some preventative effect against leprosy. Leprosy has a 5-20 year incubation period, and the symptoms are ... The Sabin Vaccine Institute, founded in 1993, works to address the issues of vaccine-preventable diseases as well as NTDs. They ... the Sabin Vaccine Institute, Norvartis Vaccines Institute for Global Health, MSD Wellcome Trust Hilleman Laboratories, ... Vaccines are under development. It can be diagnosed through a serological test, but it often produces false negatives. Soil- ...

https://en.wikipedia.org/wiki/Neglected_tropical_diseases

"BCG Vaccine against COVID-19: Dr. Megan Murray's Research & Videos". abundance.org. Retrieved June 18, 2020. Megan B. Murray ... Murray approached the Abundance Foundation with the theory that the BCG vaccine could protect people against the virus. Lowry, ...

https://en.wikipedia.org/wiki/Megan_B._Murray

... and the Qu'Appelle BCG Vaccine Trial". Canadian Bulletin of Medical History. 15 (2): 277-295. doi:10.3138/cbmh.15.2.277. PMID ... Many Nigerians mistrust the use of medical vaccines and also refuse to participate in medical trials. In 1994 United States ... were enrolled in a trial to test the tuberculosis vaccine. In both the control and treatment groups nearly a fifth died from ...

https://en.wikipedia.org/wiki/Unethical_human_experimentation

The combined vaccine was tested worldwide, but was not more effective than regular BCG. A vaccine for leishmaniasis was later ... In 1987, Convit added killed Mycobacterium leprae to the BCG vaccine. ... He is known for his efforts to promote the international development and testing of vaccines against HIV/AIDS. During 17 years ... In 1988, the Venezuelan government nominated Convit for a Nobel Prize in Medicine for his experimental anti-leprosy vaccine. ...

https://en.wikipedia.org/wiki/Science_and_technology_in_Venezuela

Tuberculosis vaccine by Albert Calmette and Camille Guérin in 1921 (BCG). Antipsychotics in 1952 by Henri Laborit ( ... of the BCG vaccine: safety, efficacy, proof, and standards, 1921-1933". Stud Hist Philos Biol Biomed Sci. 36 (4): 696-721. doi: ... Rabies vaccine by Louis Pasteur and Émile Roux in 1885. Antibiotics by Louis Pasteur and Jean Paul Vuillemin (by means of ...

https://en.wikipedia.org/wiki/List_of_French_inventions_and_discoveries

In 1987, Convit added killed Mycobacterium leprae to the BCG vaccine. The combined vaccine was tested worldwide, but was not ... This vaccine is based on the idea that cancerous cells appear and propagate because the body does not detect them. A sample of ... A vaccine for leishmaniasis was later developed using Convit's method. He also worked on onchocerciasis, mycosis, and other ... In 1988, Convit was nominated for a Nobel Prize in Medicine for his experimental anti-leprosy vaccine. The son of Francesc ...

https://en.wikipedia.org/wiki/Jacinto_Convit

Gene targeting Chemotherapy Immunotherapy BCG Vaccine Virotherapy Duong, Mai Thi-Quynh; Qin, Yeshan; You, Sung-Hwan; Min, Jung- ... BCG therapy is done by intravesical instillation (drug administration into the urinary bladder via a catheter) and has been ... Listeria-based cancer vaccines are currently being produced and are undergoing many clinical trials. Phase I trials of the ... The usage of the live attenuated strain of Mycobacterium Bovis, also known as Bacillus Calmette-Guérin (BCG), is a confirmed ...

https://en.wikipedia.org/wiki/Tumor-homing_bacteria

Here he took part in research of Bacillus Calmette-Guérin (BCG vaccine). With microbiologist Alfred Boquet (1879-1947) he ... BCG vaccination by skin scarification) with J. Breley; 1942 Prévention et traitement spécifiques de la tuberculose par le BCG ... et par l'antigène méthylique (Prevention and treatment of specific tuberculosis with BCG and antigen methyl) 1956 Service des ... 1939 Vaccination par le BCG par scarifications cutanées ( ...

https://en.wikipedia.org/wiki/Léopold_Nègre

She was interested in the controversial BCG vaccine which could protect against tuberculosis. Her work with tuberculin had ... was an Irish physician who was key to the elimination of childhood tuberculosis in Ireland by introducing the BCG vaccine. ... Few of the many thousands of children and young people who have been saved from death or tedious illness by BCG realize what ... In 1949, Price was appointed as the first chairperson of the Irish National BCG Committee. She learned German while working at ...

https://en.wikipedia.org/wiki/Dorothy_Price

It was called "BCG" (Bacille Calmette-Guérin). The BCG vaccine was first used on humans in 1921 in France, but it was not until ... Bonah C (2005). "The 'experimental stable' of the BCG vaccine: safety, efficacy, proof, and standards, 1921-1933". Stud Hist ... McKeown, who is considered as the father of social medicine, has advocated for many years, that with drugs and vaccines we may ... In Italy, Salvioli's diffusing vaccine (Vaccino Diffondente Salvioli; VDS) was used from 1948 until 1976. It was developed by ...

https://en.wikipedia.org/wiki/History_of_tuberculosis

However, the BCG vaccine was reported to reduce 50% of mortality rates in infants. Recent studies have also shown a decrease of ... A study in Guinea-Bissau showed that the BCG vaccine could decrease respiratory tract infections in children. Bacillus Calmette ... O'Neill, Luke A. J.; Netea, Mihai G. (11 May 2020). "BCG-induced trained immunity: can it offer protection against COVID-19?". ... BCG) is a vaccination developed to fight against tuberculosis and has been widely used around the world. ...

https://en.wikipedia.org/wiki/COVID-19_pandemic_in_Guinea-Bissau

A mass tuberculosis inoculation drive using the BCG vaccine gets under way.: 8 1955: The malaria eradication programme was ... 2011). "Lessons from pandemic influenza A(H1N1) The research-based vaccine industry's perspective". Vaccine. 29 (6): 1135-1138 ... doi:10.1016/j.vaccine.2010.11.042. PMID 21115061. "WHO Violence and Injury Prevention". Who.int. Archived from the original on ... As of 2012, the WHO was to report as to whether RTS,S/AS01, were a viable malaria vaccine. For the time being, insecticide- ...

https://en.wikipedia.org/wiki/World_Health_Organization

BCG disease is an adverse effect of the Bacillus Calmette-Guérin vaccine. The vaccine contains living Mycobacterium bovis BCG, ... when a Swedish-Danish BCG vaccine strain was used. To resolve the issue, Sweden discontinued mass BCG vaccinations to newborns ... while the three other registered deaths were with the new post-August 2002 vaccine (BCG vaccine SSI). Officially, vaccination ... Finland switched to a Danish-strain BCG vaccine that did not have marketing authorization in Finland. Despite a lack of ...

https://en.wikipedia.org/wiki/BCG_disease_outbreak_in_Finland_in_the_2000s

Luckily, the BCG vaccine was developed, which prevents TB meningitis and miliary TB in childhood. But, the vaccine does not ... Finding vaccines at all for some diseases remains extremely difficult. Without vaccines, the global world remains vulnerable to ... "Vaccine Basics - How Vaccines Work". vaccineinformation.org. Retrieved 2020-06-19. Union, Publications Office of the European ( ... which provide a quicker and more strategized pathway to a reliable vaccine, makes for a lengthy vaccine development timeline. ...

https://en.wikipedia.org/wiki/Globalization_and_disease

... also played a role in the development of the BCG vaccine for tuberculosis. In 1924, Shiga delivered a strain of ... With this new discovery, Shiga attempted to make a vaccine from the toxin. He tested his first attempt, a heat-killed S. ... These setbacks led Shiga to stop any further trials or production of a Shiga toxin-based vaccine. Shiga had done research on ... It was his transportation of the samples that lead scientist to culture and produce a vaccine and tuberculin to fight the ...

https://en.wikipedia.org/wiki/Kiyoshi_Shiga

Vaccine Scarring in Mothers Enhances the Survival of Their Child With a BCG Vaccine Scar". Journal of the Pediatric Infectious ... "Immunisation with the BCG and DTPw vaccines induces different programs of trained immunity in mice". Vaccine. 40 (11): 1594- ... For example, the BCG vaccine leads to a reduction in childhood mortality caused by unrelated infectious agents. The term " ... Other vaccines are also thought to induce immune training such as the DTPw vaccine. Trained immunity is thought to be largely ...

https://en.wikipedia.org/wiki/Trained_immunity

Vaccines that are on the existing immunization schedule of the government are free of charge. According to the recent 'WHO ... HepB_pediatric : birth;1, 6 months BCG : 2 months DTaPHibIPV : 2,4,6,18 months Pneumo_conj : 2,4,6,12 months MMR :12 months, 6 ... "WHO vaccine-preventable diseases: monitoring system. 2017 global summary". apps.who.int. "WHO-Diabetes Country Profiles 2016" ( ... On 2 November, the Turkish Health Ministry began administering vaccines against H1N1 influenza, starting with health workers. ...

https://en.wikipedia.org/wiki/Health_in_Turkey

BCG vaccine (contains the Brazilian substrain M. bovis BCG Moreau) Biotrombina Onko BCG Gastrotrombina Distreptaza ... Initially, vaccines against rabies, dysentery and typhoid, and Delbet's nonspecific stimulative vaccine, anti-diphtheritic and ... later the Rudolf Weigl production facility of vaccine against typhus), and shortly after that, the Serum and Vaccines factory. ... In 1960 it was renamed "Wytwórnia Surowic i Szczepionek w Lublinie" [the factory of serum and vaccines in Lublin]. The 60s of ...

https://en.wikipedia.org/wiki/Biomed-Lublin

... may refer to: Blue compact galaxy Brightest cluster galaxy BCG vaccine (Bacillus Calmette-Guérin), for tuberculosis ... US BCG matrix, for product line analysis Billy Gillispie, American basketball coach Bolt carrier group in a firearm British ... Comedy Guide Big City Greens This disambiguation page lists articles associated with the title BCG. If an internal link led you ...

https://en.wikipedia.org/wiki/BCG

The 2010 DHS in Tanzania which is the latest, presents the BCG coverage of 95.5%, DPT vaccine coverage of 88%; Polio (Pol3) ... improvements in the safety of vaccine delivery and introduction of new and underutilized vaccines. According to 2010 ... But the vaccination coverage in Tanzania presented to be more that 90% for each of the above vaccines according to World Health ...

https://en.wikipedia.org/wiki/Health_in_Tanzania

... physician who introduced the BCG tuberculosis vaccine to Ireland Sir George Stokes, 1st Baronet (1819-1903) - mathematician, ...

https://en.wikipedia.org/wiki/List_of_Irish_people

The BCG vaccine prevents severe forms of TB in children, such as TB meningitis. It would be expected that BCG would have the ... The vaccine has shown to be less effective at preventing the most common strains of TB and in blocking TB in adults. The effect ... of BCG against XDR-TB would therefore likely be very limited.[medical citation needed] The principles of treatment for MDR-TB ...

https://en.wikipedia.org/wiki/Extensively_drug-resistant_tuberculosis

BCG) vaccine against tuberculosis was invented by Albert Calmette and Camille Guérin. Research areas include Microbiology ...

https://en.wikipedia.org/wiki/Pasteur_Institute_of_Lille

"Kowbucha, seaweed, vaccines: the race to reduce cows' methane emissions". The Guardian. 30 September 2021. Retrieved 1 December ... "Food for Thought: The Untapped Climate Opportunity in Alternative Proteins". BCG. 2022-07-04. Retrieved 2022-07-10. Leger, ... vaccines, feeds, toilet-training, diet modification and grazing management. Other options include just using ruminant-free ...

https://en.wikipedia.org/wiki/Climate_change_mitigation

20th century by Albert Calmette and Camille Guérin who developed an attenuated tuberculosis vaccine called the BCG vaccine. ... vaccine Polio vaccine Rotavirus vaccine Rubella vaccine Smallpox vaccine Varicella vaccine Yellow fever vaccine Zoster/shingles ... Anthrax vaccine Cholera vaccine Plague vaccine Salmonella vaccine Tuberculosis vaccine Typhoid vaccine Live attenuated ... oral polio vaccine, recombinant live attenuated cholera vaccine, oral typhoid vaccine, oral rotavirus vaccine) Oral vaccines or ...

https://en.wikipedia.org/wiki/Attenuated_vaccine

The test may be falsely positive in those who have been previously vaccinated with BCG or have been infected by other types of ... Gradmann, Christoph (2008). "Locating Therapeutic Vaccines in Nineteenth-Century History". Science in Context. 21 (2): 145-160 ... discovered that patients who had previously received injections of horse serum or smallpox vaccine had quicker, more severe ...

https://en.wikipedia.org/wiki/Tuberculin

The cash transfers from New Incentives are conditioned by the vaccination of infants with the BCG vaccine, the pentavalent ... Other activities include improving the supply chain of vaccines and vaccine information campaigns. A randomized control trial ... vaccine, the pneumococcal conjugate vaccine and the meningococcal vaccine, which immunize them against tuberculosis, measles, ... Of these children about 40% died from vaccine-preventable diseases like pneumonia, diarrhea and measles.[citation needed] The ...

https://en.wikipedia.org/wiki/New_Incentives

These include vaccines that include live attenuated organisms, such as the MMR and BCG vaccines, since there is a potential ... Because the rubella vaccine is a live attenuated vaccine, there is a theoretical risk that it could cause fetal infection, ... for example as the DTaP vaccine (which also protects against diphtheria) or the 4-in-1 vaccine (which also protects against ... The tetanus toxoid vaccine was first licensed for use in 1938 and, during the 1960s, it was noted that tetanus vaccination in ...

https://en.wikipedia.org/wiki/Immunization_during_pregnancy

is engaged in development of the vaccine for COVID-19 prevention. SeV serves as a vaccine backbone vector in the project. SeV ... May 2017). "Sendai Virus Mucosal Vaccination Establishes Lung-Resident Memory CD8T Cell Immunity and Boosts BCG-Primed ... January 2012). "Sendai virus-based RSV vaccine protects African green monkeys from RSV infection". Vaccine. 30 (5): 959-68. doi ... Parks CL (2017). "Replication-Competent Viral Vectors for Vaccine Delivery". Human Vaccines. Elsevier. pp. 25-63. doi:10.1016/ ...

https://en.wikipedia.org/wiki/Murine_respirovirus

... in the US testers are told to ignore the possibility of false positive due to the BCG vaccine, as the BCG is seen as having ... This can also be triggered by receiving the BCG vaccine, as opposed to a proper infection. Although boosting can occur in any ... or the BCG itself. In the case of BCG vaccinations confusing the results, Interferon-γ (IFN-γ) tests may be used as they will ... In patients who have not had BCG previously, latent TB is diagnosed if the Heaf test is grade 2, 3 or 4, and have no signs or ...

https://en.wikipedia.org/wiki/Latent_tuberculosis

BCG disease outbreak in Finland in the 2000s National public health institutes A. S. Härö and V. Raunio: Seerumit aseina - ... KTL also did research with private funds in the fields of vaccines and nutrition. Private funding has drawn criticism from some ... KTL also acquired and distributed the vaccines paid by the government. KTL was merged on 1 January 2009 with STAKES, the ... Top quality research at KTL included early work on interferons by Kari Cantell, research on several bacterial vaccines by Pirjo ...

https://en.wikipedia.org/wiki/National_Public_Health_Institute_of_Finland

Kasauli and BCG Vaccine Laboratory, Chennai. Later during 2010, the suspension was revoked and Union Government of India ... DPT Vaccine (ii) DT Vaccine and (iii) TT Vaccine supplying to Universal Immunization Programme (UIP). Pasteur Institute of ... Pasteur Institute of India, Coonoor is producing Vero Cell Derived Rabies Vaccine for Human use and DPT group vaccines ... dog bite vaccine) and DPT vaccine (triple antigen) for the Expanded Programme of Immunization of Government of India. This ...

https://en.wikipedia.org/wiki/Pasteur_Institute_of_India

It is a form of prostatitis (prostate inflammation), resulting from infection (bacterial, viral, or fungal), BCG vaccine, ...

https://en.wikipedia.org/wiki/Granulomatous_prostatitis

... mostly based on the Mycobacterium bovis strain used in the BCG vaccine. The BCG vaccine and versions of the vaccine that also ... There is no specific vaccine for preventing Buruli ulcer. The BCG vaccine typically given to children to protect against ... As of 2019, no vaccine tested completely protects mice from infection. M. ulcerans can be grown in laboratory media, although ... Zimmerman P, Finn A, Curtis N (July 2018). "Does BCG vaccination protect against nontuberculous mycobacterial infection? A ...

https://en.wikipedia.org/wiki/Buruli_ulcer

... produced BCG vaccine products made with the Glaxo 1077 strain, such as a tuberculosis vaccine and ImmuCYST, a BCG ... C MMR vaccines M-M-RVaxPro Pneumonia vaccines Pneumo 23 Polio vaccines Imovax Polio Ipol Polio Salk Rabies vaccines IMOVAX ... Vaccin Bcg Ssi Typhoid fever vaccines Typhim Vi Yellow fever vaccines Stamaril YF-VAX Diphtheria and tetanus combined vaccines ... Pasteur Rubella vaccines Rudivax Smallpox vaccines ACAM 2000 Tetanus vaccines Vaccin Tetanique Pasteur Tuberculosis vaccines ...

https://en.wikipedia.org/wiki/Sanofi_Pasteur

"A personalized vaccine for breast cancer - Research • Breast Cancer Foundation NZ". www.breastcancerfoundation.org.nz. "Virus ... After a 2000 PhD titled 'Immunological responses to live and live recombinant BCG in a murine model ' at the University of ...

https://en.wikipedia.org/wiki/Sarah_Young_(immunologist)

Initially, the vaccines consisted of Bacillus Calmette-Guérin (BCG) vaccine, oral polio vaccine (OPV), measles vaccine (MV) and ... vaccine Chickenpox vaccine (varicella) COVID-19 vaccine Diphteria vaccine, included in the DPT vaccine Influenza (flu) vaccine ... pentavalent and hexavalent vaccines Pneumococcus vaccine Polio vaccine, included in the hexavalent vaccine Rabies vaccines ... included in the MMR vaccine Meningococcus vaccine Mumps vaccine, included in the MMR vaccine Pertussis (whooping cough) vaccine ...

https://en.wikipedia.org/wiki/Vaccination_policy

"In the battle against tuberculosis, a portrait of Calmette, as the saviour of children through his BCG vaccine, invites the ...

https://en.wikipedia.org/wiki/Henri-Lucien_Cheffer

... making them ideal as a vaccine adjuvant. Weiner GJ, Liu HM, Wooldridge JE, Dahle CE, Krieg AM (September 1997). " ... "Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical ... been the focus of intense research due to the Type I pro-inflammatory response they elicit and their successful use as vaccine ...

https://en.wikipedia.org/wiki/CpG_oligodeoxynucleotide

... consensus Antibiotic resistance Antiviral drug BCG disease outbreak in Finland in the 2000s Bioterrorism Clostridium vaccine ... vaccine Caries vaccine Gonorrhea vaccine Ehrlichiosis vaccine Helicobacter pylori vaccine Leprosy vaccine Lyme disease vaccine ... vaccine Tularemia vaccine Yersinia pestis vaccine Chagas disease vaccine Hookworm vaccine Leishmaniasis vaccine Malaria vaccine ... encephalitis virus vaccine for humans Enterovirus 71 vaccine Epstein-Barr vaccine H5N1 vaccine Hepatitis C vaccine HIV vaccine ...

https://en.wikipedia.org/wiki/List_of_vaccine_topics

As of 2015, 97.2% of children aged 0 to 11 months had received the DPT vaccine, 76.0% had received the BCG vaccine, and 97.4% ... had received the polio vaccine. As of 2008, the literacy rate for people aged 15 years and over was 63.6%. The net enrollment ...

https://en.wikipedia.org/wiki/Inchiri_Region

Bacillus Calmette-Guérin (BCG) was approved by the FDA in 1990 as a vaccine for early-stage bladder cancer. BCG can be ... Vaccines that treat existing cancer are known as therapeutic cancer vaccines or tumor antigen vaccines. Some of the vaccines ... Immunotherapy Cancer immunotherapy Coley's toxins Chemoprophylaxis HPV vaccines Therapeutic vaccines Tumor antigen vaccine Kwok ... Tumor antigen vaccines work the same way that viral vaccines work, by training the immune system to attack cells that contain ...

https://en.wikipedia.org/wiki/Cancer_vaccine

... a vaccine for tuberculosis disease. Provided by the Centers for Disease Control and Prevention (CDC). ... BCG Vaccine. Introduction. BCG, or bacille Calmette-Guerin, is a vaccine for tuberculosis (TB) disease. Many foreign-born ... and the vaccines potential interference with tuberculin skin test reactivity. The BCG vaccine should be considered only for ... The role of BCG vaccine in the prevention and control of tuberculosis in the United States: a joint statement by ACET and the ...

https://www.cdc.gov/tb/publications/factsheets/prevention/BCG.htm

BCG vaccination policies : report of a WHO study group [‎meeting held in Geneva from 24 to 27 June 1980]‎ ... BCG vaccination : studies by the WHO Tuberculosis Research Office, Copenhagen / report prepared under the direction of Lydia B ... BCG vaccination of the newborn : rationale and guidelines for country programmes / Tuberculosis and Respiratory Infections Unit ... WHO Study Group on BCG Vaccination Policies; World Health Organization (‎World Health OrganizationWorld Health Organization, ...

https://apps.who.int:80/iris/browse?authority=BCG+Vaccine&type=mesh

Vaccine: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Before receiving BCG vaccine, *tell your doctor and pharmacist if you are allergic to BCG vaccine or any other drugs. ... BCG vaccine provides immunity or protection against tuberculosis (TB). The vaccine may be given to persons at high risk of ... BCG vaccine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: *swollen lymph ...

https://medlineplus.gov/druginfo/meds/a682809.html

Although the BCG vaccine may keep severe forms of tuberculosis, meningitis, and miliary tuberculosis at bay, its efficacy and ... New Vaccines Needed The BCG vaccine is one of the oldest vaccines, but there are still several crucial unanswered questions ... However, he cited a study conducted in South Africa in which the BCG vaccine was compared with another vaccine, and another ... "Today, thanks to the BCG vaccine, we dont see it anymore." However, she pointed out that the vaccines efficacy and ...

http://www.medscape.com/viewarticle/984995

Sato, H., Diena, B. B. & Greenberg, L. (‎1967)‎. Lysed BCG vaccines. Bulletin of the World Health Organization, 37 (‎6)‎, 967 ...

https://extranet.who.int/iris/restricted/handle/10665/266322?locale-attribute=pt&

... bcg vaccines, vaccine bcg, bcg vaccine, Bacillus Calmette-Guerin vaccine, BCG vaccine, BCG vaccine (product), BCG vaccine ( ... BCG Vaccine, Calmette Guerin Bacillus Vaccine, Calmette Vaccine, Calmettes Vaccine, Calmettes Vaccine, Vaccine, BCG, Vaccine, ... Adult Vaccination BCG vaccine Cholera Vaccine Covid-19 Vaccine DTaP Vaccine Hepatitis A Vaccine Hepatitis B Vaccine Hib Vaccine ... Serotype B Meningococcal Vaccine Smallpox Vaccine Td Vaccine Tdap Vaccine Twinrix Typhoid Vaccine Vaccine Vaccines in ...

https://fpnotebook.com/id/Immunize/BcgVcn.htm

... to 18-month timeline assumes that a vaccine progresses through all the various stages of testing without encountering ... In this article we examine the outlook for a vaccine or vaccines. It is based on broader research conducted by the BCG ... For information or permission to reprint, please contact BCG at [email protected]bcg.com. To find the latest BCG content and ... Multiple vaccine modalities are in development and in clinical trials, including traditional protein subunit vaccines, whole- ...

https://www.bcg.com/publications/2020/covid-vaccines-timelines-implications

Remove BCG vaccine (birth-6 months) filter BCG vaccine (birth-6 months) ...

https://www.healthed.govt.nz/search?type=resource&language=All&organisation=All&topic%5B0%5D=28&online_only=All&sort_order=DESC&mode=list-view&f%5B0%5D=language%3Aso&f%5B1%5D=field_health_topics%3A7&f%5B2%5D=field_health_topics%3A28&sort_by=field_resource_item_title

Institute has claimed some success in mitigating the effects of the Covid-19 virus in patients injected with the BCG vaccine. ... BCG vaccine to be tested in Covid-19 battle. Mumbai institute claims some success in mitigating coronavirus effects. ... The BCG vaccine is used universally across India to immunise children against tuberculosis and meningitis. Newborn children are ... However, the efficacy of the BCG vaccine on those found to have tested positive for the Covid-19 virus need to be established ...

https://www.tribuneindia.com/news/nation/bcg-vaccine-to-be-tested-in-covid-19-battle-71090

After a change in BCG vaccine strains in Georgia to the exclusive use of BCG SSI vaccine, we found a substantial increase in ... Countries with a BCG vaccination policy should have a clear protocol on management of BCG vaccine-related adverse events to ... In summary, we found an increasing rate of BCG-associated lymphadenitis after a shift to exclusive BCG SSI vaccine use in ... To the Editor: Bacillus Calmette-Guérin (BCG) vaccine is one of the most commonly used vaccines for tuberculosis (TB) worldwide ...

https://wwwnc.cdc.gov/eid/article/21/9/15-0289_article

Considering BCG vaccination to reduce the impact of COVID-19. *Bacille Calmette Guérin (BCG) and new TB vaccines: Specific, ... These new aims focus on whether the BCG vaccine improves the bodys response SARS-CoV-2 vaccines in health care workers; and ... Prevention of COVID-19: BCG vaccine Professor Nigel Curtis is leading an international randomised controlled trial, known as ... It does this by inducing a process termed "trained immunity". It is anticipated that the BCG vaccine might therefore reduce ...

https://www.mcri.edu.au/research/strategic-collaborations/flagships/covid-19/research/prevention-of-covid-19-bcg-vaccine

... of BCG-treated individuals met criteria for confirmed COVID-19, yielding a vaccine effectiveness of 92%. ... The researchers are hoping the results will spur a larger scale study of the effects of the BCG vaccine in patients with type 1 ... The BCG vaccine is an avirulent tuberculosis strain Mycobacterium bovis historically given to protect against tuberculosis and ... Unlike the antigen-specific vaccines currently in use to prevent COVID-19, BCGs mechanism of action is not limited to a ...

https://www.massgeneral.org/news/press-release/multiple-shots-bcg-vaccine-protect-type-1-diabetics

Despite unprecedented efforts, with vaccines being developed in a record time, SARS-CoV-2 continues to spread worldwide with ... 5 million possible cross-reactive peptide pairs from BCG and SARS-CoV-2. Our study produced (i) a list of immunogenic BCG- ... Our study expands the list of BCG peptides potentially involved in T cell cross-reactivity with SARS-CoV-2-derived peptides, ... The protection against SARS-CoV-2 induced by BCG vaccination may be mediated by cross-reactive T cell lymphocytes, which ...

https://www.frontiersin.org/articles/10.3389/fimmu.2021.812176/full?&utm_source=Email_to_authors_&utm_medium=Email&utm_content=T1_11.5e1_author&utm_campaign=Email_publication&field=&journalName=Frontiers_in_Immunology&id=812176

The Role of BCG Vaccine in the Prevention and Control of Tuberculosis in the United States A Joint Statement by the Advisory ... and implementation and surveillance of BCG vaccination. BCG VACCINES BCG vaccines are live vaccines derived from a strain of ... BCG VACCINATION DURING PREGNANCY Although no harmful effects to the fetus have been associated with BCG vaccine, its use is not ... Vaccine Efficacy Reported rates of the protective efficacy of BCG vaccines might have been affected by the methods and routes ...

https://wonder.cdc.gov/wonder/prevguid/m0041047/m0041047.asp

This website uses cookies to improve your experience while you navigate through the website. Out of these, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may affect your browsing experience ...

https://www.cmr.ro/anmdmr-informare-bcg-10-anti-tuberculosis-vaccine_4582/

Tuberculose lymphonodale cervicale chez les enfants vaccines par le BCG * R Ben Mhamed ... BCG vaccination has reduced considerably the number of severe but does not protect completely against this disease.. ... The purpose of this work was to study the diagnostic and therapeutic features in children vaccinated with BCG.. Material and ... La vaccination par le BCG a permis de diminuer considérablement le nombre des formes graves mais ne protège pas parfaitement ...

https://www.ajol.info/index.php/jtdorl/article/view/114238

This is an Australian study published in Science which for the first time details this mechanism which the discoverer of BCG, ... "of this BCG vaccine on diabetes. Result: there were no cases of Covid in the group which had received three doses of BCG, ... This is a protection that we see with other vaccines. On all the so-called vaccines "living" (those inoculated with the still ... "covid type" one could imagine that BCG protects populations, the time to find a vaccine? In the United States, a study was ...

https://rebelinkpress.com/the-bcg-vaccine-protects-well-beyond-tuberculosis/

... To fight tuberculosis, LJI scientists uncover the key immune cells in play after BCG vaccination. ... The researchers wanted to know which kinds of immune cells respond to the BCG vaccine and "remember" the vaccine well enough to ... The problem is that the BCG vaccine was the first-and the last-vaccine approved to prevent tuberculosis. ... LA JOLLA-A long, long time ago, the BCG vaccine was approved for use against tuberculosis (TB), and its still given to infants ...

https://www.lji.org/news-events/news/post/once-upon-a-bcg-vaccine/

Bacillus Calmette-Guérin Vaccine (BCG) / TB vaccine Bacillus Calmette-Guérin Vaccine (BCG) / TB vaccine The BCG (Bacillus ... Only one dose of the BCG Vaccine is required.. If the BCG vaccine is recommended for your baby, it will usually be offered ... About the BCG vaccine. The vaccine used in the UK is BCG AJV. ... Eligibility for the vaccine. Since 2005 the BCG vaccine is no ... Side effects of the BCG vaccine. Virtually everyone who has a BCG vaccination will develop a raised blister at the site of the ...

https://phw.nhs.wales/topics/immunisation-and-vaccines/vaccination-information1/bcg-tb-vaccine/

... below the level in BCG-immunized animals. A recombinant BCG vaccine overexpressing the identical M. bovis 30kDa protein, ... As rBCG30 is significantly more potent than BCG against M. bovis challenge, it has potential as a vaccine against bovine ... However, the only currently available vaccine, M. bovis Bacille Calmette-Guerin (BCG), is not highly efficacious. Here we show ... As for potency, in three independent experiments, rBCG30 induced greater protective immunity than BCG against aerosol challenge ...

https://escholarship.org/uc/item/6p6663p1

... Diagnosis Tuberculin Test Tuberculosis BCG Vaccine/Patient Education Handout Tuberculin Test/Patient Education ... "BCG, or bacille Calmette-Guerin, is a vaccine for tuberculosis (TB) disease. Many foreign-born persons have been BCG-vaccinated ... and the vaccines potential interference with tuberculin skin test reactivity. The BCG vaccine should be considered only for ... Title : BCG vaccine Corporate Authors(s) : National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (U.S.), ...

https://stacks.cdc.gov/view/cdc/5888

... vaccine, primarily used against tuberculosis, is effective in preventing COVID-19 in elderly population ... "The BCG vaccine has offered hope to the elderly, and if found effective, it will help bring down morbidity and mortality in ... The BCG vaccine will be administered after obtaining informed consent from participants who will then be closely monitored for ... Mumbai, Aug 21 (PTI): The ICMR is undertaking a study in Mumbai to evaluate whether the BCG (Bacille Calmette- Guerin) vaccine ...

https://easternmirrornagaland.com/covid-19-study-to-find-effectiveness-of-bcg-vaccine-in-elders/

Global BCG Vaccine Market Report offers analysis of Types and Analysis by Sales (Unit) and Market Share (%), Revenue (Million ... 8 Global BCG Vaccine Players Profiles and Sales Data. 9 Upstream and Downstream Analysis of BCG Vaccine. 10 Global BCG Vaccine ... 2 Global BCG Vaccine Competitions by Players. 3 Global BCG Vaccine Competitions by Types. 4 Global BCG Vaccine Competitions by ... 5 Global BCG Vaccine Production Market Analysis by Region. 6 Global BCG Vaccine Sales Market Analysis by Region. 7 Imports and ...

https://news.marketersmedia.com/global-bcg-vaccine-market-to-2022-production-consumption-revenue-gross-margin-and-more/250371

The effect of current Schistosoma mansoni infection on the immunogenicity of a candidate TB vaccine, MVA85A, in BCG-vaccinated ... The effect of current Schistosoma mansoni infection on the immunogenicity of a candidate TB vaccine, MVA85A, in BCG-vaccinated ... It takes a village: developing a vaccine * Oxford University Overseas Clinical Research Units: what do we do and why do we do ...

https://www.ndm.ox.ac.uk/publications/695681

https://www.staging.medscape.com/viewarticle/984995

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Health care workers considered for BCG vaccination should be counseled regarding the risks and benefits associated with both BCG vaccination and treatment of Latent TB Infection (LTBI). (cdc.gov)
BCG vaccination should not be given to persons who are immunosuppressed (e.g., persons who are HIV infected) or who are likely to become immunocompromised (e.g., persons who are candidates for organ transplant). (cdc.gov)
BCG vaccination should not be given during pregnancy. (cdc.gov)
Even though no harmful effects of BCG vaccination on the fetus have been observed, further studies are needed to prove its safety. (cdc.gov)
BCG vaccination may cause a false-positive reaction to the TST, which may complicate decisions about prescribing treatment. (cdc.gov)
Furthermore, the size of a TST reaction in a BCG-vaccinated person is not a factor in determining whether the reaction is caused by LTBI or the prior BCG vaccination. (cdc.gov)
Blood tests to detect TB infection, unlike the TST, are not affected by prior BCG vaccination and are less likely to give a false-positive result. (cdc.gov)
Keep the vaccination area dry for 24 hours after receiving the vaccine, and keep the area clean until you cannot tell the vaccination area from the skin around it. (medlineplus.gov)
Bacillus Calmette-Guérin (BCG) vaccines are given to more than 100 million children every year, but there is considerable debate regarding the effectiveness of BCG vaccination in preventing tuberculosis and death, particularly among older children and adults. (medscape.com)
BCG vaccination was protective against pulmonary tuberculosis (19% effectiveness), but this effect was only seen in children younger than 3 years (42% effectiveness) when stratified by age. (medscape.com)
Vaccination with BCG vaccine may be immunoprotective against infection with Mycobacterium tuberculosis. (fpnotebook.com)
Once a vaccine is scientifically validated, it must be produced at a scale that can enable herd immunity (which can result from either vaccination or previous infection) on a global scale. (bcg.com)
Initial research by the Haffkine Institute indicates that patients who have already tested positive for the Covid-19 virus but with mild symptoms could prevent worsening of their condition following a fresh round of the BCG vaccination, according to officials here. (tribuneindia.com)
The most common severe adverse events related to BCG vaccination are nonsuppurative and suppurative lymphadenitis. (cdc.gov)
BCG lymphadenitis was clinically defined as ipsilateral axillary lymph node enlargement developing within 2 years after vaccination. (cdc.gov)
Based on the following calculation-16 cases/(14,230 live-born infants × 96% vaccination coverage)-the estimated prevalence of BCG-related suppurative lymphadenitis in 2012 was 1.12 cases per 1,000 infants. (cdc.gov)
Median time from BCG vaccination to onset of lymphadenitis was 5 months (range 1-15 months). (cdc.gov)
In this webinar, we heard from Prof Nigel Curtis, the Chief Principal Investigator of the BRACE trial of BCG vaccination to reduce the impact of COVID-19, about the challenges of running the BRACE trial during a pandemic. (edu.au)
The BRACE trial is an international randomised controlled trial to determine the effectiveness of BCG vaccination in reducing incidence and severity of COVID-19 in healthcare workers. (edu.au)
This study aims to understand if BCG vaccination can reduce the severity of COVID-19 disease, and investigate its role in the evolving pandemic. (edu.au)
Prior to the trial they had no known exposure to tuberculosis or prior BCG vaccination. (massgeneral.org)
Such persistent spread is in part enabled by public resistance to vaccination in some countries, and limited access to vaccines in other countries. (frontiersin.org)
At the beginning of the pandemic it was suggested that countries with Bacillus Calmette-Guérin (BCG) vaccination programs could be associated with a reduced number and/or severity of COVID-19 cases. (frontiersin.org)
The protection against SARS-CoV-2 induced by BCG vaccination may be mediated by cross-reactive T cell lymphocytes, which recognize peptides displayed by class I Human Leukocyte Antigens (HLA-I) on the surface of infected cells. (frontiersin.org)
Our study expands the list of BCG peptides potentially involved in T cell cross-reactivity with SARS-CoV-2-derived peptides, and identifies multiple high-density "neighborhoods" of cross-reactive peptides which could be driving heterologous immunity induced by BCG vaccination, therefore providing insights for future vaccine development efforts. (frontiersin.org)
Despite the success of COVID-19 vaccines, mistrust and misinformation from segments of society, lack of resources in low-income countries, and impaired international coordination are all contributing to very limited vaccination coverage worldwide, a picture that will not change in the short-term. (frontiersin.org)
The concern of the public health community about the resurgence and changing nature of TB in the United States prompted a re-evaluation of the role of BCG vaccination in the prevention and control of TB. (cdc.gov)
The use of BCG vaccine has been limited because a) its effectiveness in preventing infectious forms of TB is uncertain and b) the reactivity to tuberculin that occurs after vaccination interferes with the management of persons who are possibly infected with M. tuberculosis. (cdc.gov)
In the United States, the use of BCG vaccination as a TB prevention strategy is reserved for selected persons who meet specific criteria. (cdc.gov)
BCG vaccination should be considered for infants and children who reside in settings in which the likelihood of M. tuberculosis transmission and subsequent infection is high, provided no other measures can be implemented (e.g., removing the child from the source of infection). (cdc.gov)
In addition, BCG vaccination may be considered for health-care workers (HCWs) who are employed in settings in which the likelihood of transmission and subsequent infection with M. tuberculosis strains resistant to isoniazid and rifampin is high, provided comprehensive TB infection-control precautions have been implemented in the workplace and have not been successful. (cdc.gov)
BCG vaccination is not recommended for children and adults who are infected with human immunodeficiency virus because of the potential adverse reactions associated with the use of the vaccine in these persons. (cdc.gov)
In the United States, the use of BCG vaccination is rarely indicated. (cdc.gov)
La vaccination par le BCG a permis de diminuer considérablement le nombre des formes graves mais ne protège pas parfaitement contre cette maladie. (ajol.info)
BCG vaccination has reduced considerably the number of severe but does not protect completely against this disease. (ajol.info)
In France, this would mean relaunching the BCG vaccination, which is no longer mandatory, just recommended in France since 2007 - the coverage rate is now 58% according to figures from Public Health France. (rebelinkpress.com)
A better understanding of BCG vaccination could serve as a foundation for designing more effective TB vaccines. (lji.org)
Close up of reaction of Bacillus Calmette Guerin or BCG vaccination in an infant. (lji.org)
These Th1* cells are a key marker in the body's "immune signature" following BCG vaccination. (lji.org)
After 100 years, the researchers had uncovered a clue to the very workings of BCG vaccination. (lji.org)
Now Lindestam Arlehamn could see that Th1* and MAIT cells were key players after BCG vaccination as well. (lji.org)
Kids typically have a better response to BCG vaccination which prevents more severe TB cases. (lji.org)
The BCG vaccination is particularly effective in protecting babies and young children against the more rare severe forms of TB such as TB meningitis (swelling of the lining of the brain). (nhs.wales)
Since 2005 the BCG vaccine is no longer given as part of the routine NHS vaccination schedule. (nhs.wales)
Virtually everyone who has a BCG vaccination will develop a raised blister at the site of the injection immediately afterwards. (nhs.wales)
Vaccination with the BCG vaccine is effective in reducing the incidence of TB meningitis and death in children less than 5 years of age in countries where TB is prevalent. (edu.au)
BCG vaccination for individuals travelling to areas with a high incidence of disease is ideally administered 4-6 weeks prior to travel. (edu.au)
Tuberculin skin testing (TST) or Mantoux testing prior to BCG vaccination is recommended on a case-by case basis to determine if a person already has a level of immunity to TB. (edu.au)
Only healthcare providers trained in intradermal technique should provide BCG vaccination. (edu.au)
The germs in the BCG vaccination can occasionally induce a slow-developing infection and enlarge the lymph node around the injection site. (livlong.com)
According to the national registry of adverse vaccination responses, the Danish BCG vaccine causes a festering infection in the inguinal lymph nodes. (livlong.com)
Such adverse responses have been seen in around one kid out of every 7,000 vaccination recipients when using the Danish BCG vaccine. (livlong.com)
New vaccine is required to vaccination requirements for the usa or friends and. (malamahealth.online)
The innate immune system a tool against some people with bcg may therefore limiting factor for vaccination prevents infant indians and disease or illness. (malamahealth.online)
Bcg vaccination requirements for bcg vaccine has a tuberculosis in general population, depending on immunization vary substantially across texas. (malamahealth.online)
Bcg vaccination in the number of the number of mayo clinic covid vaccine bcg? (malamahealth.online)
What are different vaccination requirements, of bcg vaccination with friends about a century old vaccine could improve the ground on improving vaccines. (malamahealth.online)
Bcg vaccination policy and reporting biases as necessary for your personal protective is required to exclude potential conflict of the pandemic to be. (malamahealth.online)
There is swelling at the site of bcg vaccination. (practo.com)
My baby got BCG vaccination at the time of birth. (practo.com)
Hi, Mt baby is 10 weeks old and the red bump of bcg vaccination site is oozing pus. (practo.com)
A study posted on March 28 in a preprint server medRxiv found an association between countries that have a universal BCG vaccination and reduced coronavirus cases and even deaths. (journosdiary.com)
According to them, the association of fewer coronavirus cases in countries that have a universal BCG vaccination programme is based on population rather than individual data. (journosdiary.com)
Fourth, if not effective against coronavirus, BCG vaccination is likely to give a false sense of security to people, especially during the pandemic. (journosdiary.com)
BCG vaccination in our hands led to a reduction in bacterial burden after challenge with Mycobacterium tuberculosis of approx. (bvsalud.org)
However, it is intriguing to observe that the incidence and morbidity of the disease varies greatly in different regions of the globe, being highest in Africa and Asia, as well as the response to BCG vaccination [ 1 , 4 ]. (intechopen.com)
Parenteral BCG vaccination has been shown to drive innate immune memory responses that can affect the response to pathogens other than mycobacteria. (nature.com)
Here the authors show an innate immune memory mechanism whereby subcutaneous BCG vaccination alters the intestinal microbiome and in turn can train alveolar macrophages in the lungs. (nature.com)
The immune boosting benefits of a tuberculosis vaccine can be seen in infants more than one year after vaccination, according to a new study. (news-medical.net)
Bacillus Calmette-Guerin (BCG) vaccination is a promising treatment that could cure type 1 diabetes. (allhealthsite.com)
In Madagascar, the current vaccination calendar provides for the administration of a number of vaccines for free, for children from 0 to 18 months. (who.int)
BCG vaccination is only recommended on the NHS for babies, children and adults under the age of 35 who are considered at risk of catching tuberculosis (TB). (havering.gov.uk)
It also explains how to interpret tuberculin skin test results in people who have received the vaccination and the treatment for LTBI in BCG-vaccinated persons. (cdc.gov)
Lack of a timely receipt of vaccines can cause uncertain immune response and under-vaccination. (annalsofglobalhealth.org)
To identify the age of presentation for the birth dose vaccines, vaccine antigens received and factors associated with vaccination presentation by day one in Northern Nigeria. (annalsofglobalhealth.org)
Data was collected using a questionnaire including the socio-demographic, antenatal care (ANC), delivery details, birth dates, vaccination presentation and birth vaccine antigens received. (annalsofglobalhealth.org)
Furthermore, some babies do not get the required vaccines despite presenting for vaccination due to stockout. (annalsofglobalhealth.org)
Unfortunately, vaccination uptake remains low in developing countries with the highest burden of vaccine-preventable diseases. (annalsofglobalhealth.org)
Nowadays these bacteria are believed to have an important role in infections, allergies, immunity to other pulmonary infections and the efficacy of bacille Calmette-Guerin (BCG) vaccination [3]. (who.int)
it can also affect the efficacy of BCG vaccination [3,7-9]. (who.int)
Bacille Calmette-Guérin (BCG) vaccination at birth and antibody responses to childhood vaccines. (technet-21.org)
INTRODUCTION: BCG vaccination has been associated with beneficial non-specific effects on child health. (technet-21.org)
Intradermal bacille Calmette-Guérin (BCG) vaccination by needle-free, disposable-syringe jet injectors (DSJI) is an alternative to the Mantoux method using needle and syringe (NS). (technet-21.org)
Live Attenuated Virus Vaccines This paper from Massachusetts found that vaccination with the tuberculosis BCG vaccine gave a 92% efficacy against COVID-19. (webfoot.com)
Receipt of BCG vaccination prior to enrolment. (who.int)
BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity. (harvard.edu)
One Full or Two Fractional Doses of Inactivated Poliovirus Vaccine for Catch-up Vaccination in Older Infants: A Randomized Clinical Trial in Bangladesh. (rsdjournal.org)

A longer timeline of 24 to 36 months (2022 to 2023) would still represent a record in vaccine development. (bcg.com)
Candidates can check the latest BCG Vaccine Laboratory Recruitment 2022 Administrative Officer Vacancy 2022 details and apply online at the dirbcglab.gov.in/ recruitment 2022 page. (mysarkarinaukri.com)

BCG vaccine provides immunity or protection against tuberculosis (TB). (medlineplus.gov)
The Maharashtra government had asked the Haffkine Institute to carry out research on the efficacy of the BCG vaccine in combating the Covid-19 virus after experts advised that it boosted immunity in patients. (tribuneindia.com)
The civic body said there is evidence to suggest that the BCG vaccine, normally given to children for immunity against tuberculosis, has protective effect against other respiratory tract infections, including viral diseases. (easternmirrornagaland.com)
Trained immunity these vaccines improving tb is recommended by the usa where are. (malamahealth.online)
Contact with different species of environmental Mycobacterium can cause acquired immunity to M. tuberculosis or increase the efficacy of BCG vaccine protection (M. vaccae, M. microti), although some species of these bacteria reduce the efficacy of BCG vaccine (M. scrofulaceum) [8,10-13]. (who.int)
The lead investigator on the study was Professor Terry Nolan , head of the Vaccine and Immunisation Research Group (VIRGo) at the Murdoch Children's Research Institute (MCRI) , and the Peter Doherty Institute for Infection and Immunity at the University of Melbourne. (edu.au)

Although the mechanism of its anti-tumor activity is unclear, immunization with BCG vaccine likely activates a Th1 cytokine response that includes the induction of interferon. (fpnotebook.com)
This updated report is being issued by CDC, the Advisory Committee for the Elimination of Tuberculosis, and the Advisory Committee on Immunization Practices, in consultation with the Hospital Infection Control Practices Advisory Committee, to summarize current considerations and recommendations regarding the use of BCG vaccine in the United States. (cdc.gov)
Typical responses are anticipated for the side effects of the bcg vaccine, as Rachel found to find out after two to six weeks of receiving the BCG vaccine, a tiny lump will form at the immunization site. (livlong.com)
In rare situations, the bacteria in the BCG vaccine may induce illness at a location other than the immunization site. (livlong.com)
We also maintain an online record, accessible through our website by the patients themselves, of all vaccines given to any person at our Immunization clinic. (salmanbajwa.com)
National immunization campaigns with oral polio vaccine may reduce all-cause mortality: An analysis of 13 years of demographic surveillance data from an urban African area. (rsdjournal.org)
NI-ABAE has been working in Nigeria since 2017, providing conditional cash incentives to select parents, to avail their infants access to full immunization against childhood-killer diseases, including BCG (against tuberculosis), PENTA (against diphtheria, tetanus, whooping cough, hepatitis B and Haemophilus influenzae type b), PCV (against pneumococcal disease), and MCV 1&2 (against measles). (legit.ng)

However, BCG is not generally recommended for use in the United States because of the low risk of infection with Mycobacterium tuberculosis , the variable effectiveness of the vaccine against adult pulmonary TB, and the vaccine's potential interference with tuberculin skin test reactivity. (cdc.gov)
The tuberculin skin test (TST) and blood tests to detect TB infection are not contraindicated for persons who have been vaccinated with BCG. (cdc.gov)
We found that three doses of BCG administered prior to the start of the pandemic prevented infection and limited severe symptoms from COVID-19 and other infectious diseases. (massgeneral.org)
Unlike the antigen-specific vaccines currently in use to prevent COVID-19, BCG's mechanism of action is not limited to a specific virus or infection," says Denise Faustman, MD, PhD, director of the Immunobiology Laboratory at Massachusetts General Hospital. (massgeneral.org)
It is important to note that TST results may be unreliable for 4-6 weeks following a measles infection or receiving a measles-containing vaccine. (edu.au)
Immunosuppressives may diminish therapeutic effects of vaccines and increase risk of adverse effects (increased risk of infection). (medscape.com)
In bcg in a contagious or has already met with the requirements for more on the primary infection can determine which was confined by a new antigen of. (malamahealth.online)
An effective vaccine against Chlamydia trachomatis is urgently needed as infection rates continue to rise and C. trachomatis causes reproductive morbidity. (ipaqt.org)
The COVID-19 vaccine should not be delayed because of testing for TB infection. (cdc.gov)

And Professor Locht to report the concern of his Danish research colleagues who expect a resumption of mortality among children when the drinkable polio vaccine will soon be withdrawn from the market. (rebelinkpress.com)
The most frequently received antigen was theBacille-Calmette-Guerinby 1 781 infants (91.2%), oral polio vaccine 1 703 (87.2%), and hepatitis B vaccine birth dose the lowest at 75.1% (1 565). (annalsofglobalhealth.org)

Do successful tuberculosis vaccines need to be immunoregulatory rather than merely Th1-boosting? (nih.gov)

That will probably mean coverage of more than 60% of the world's population, which could require up to 5 billion doses for a single-dose vaccine and more than 10 billion doses for a multidose vaccine. (bcg.com)
BOSTON - Researchers at Massachusetts General Hospital (MGH), published a new paper in Cell Reports Medicine demonstrating the protective potential of multiple doses of the Bacillus Calmette-Guerin (BCG) vaccine against COVID-19 and other infectious diseases. (massgeneral.org)
This data set is unique and exciting because the patients were all vaccinated with multiple doses of BCG prior to the onset of the epidemic. (massgeneral.org)
Result: there were no cases of Covid in the group which had received three doses of BCG, unlike the unvaccinated group. (rebelinkpress.com)
In particular, randomized control trials of children in Guinea- Bissau which looked at mortality up to the age of 9 months showed a low number of deaths post administration of the 3 doses of the measles vaccine over the study follow up period. (immunizationevidence.org)
This is a proven platform, which was used to produce thousands of doses of company's Ebola vaccine deployed in the Congo in November 2019. (allianceforscience.org)
Johnson & Johnson, while it has the corporate muscle to produce vaccine doses in large quantities, doesn't expect to start Phase 1 trials until September, which it says could possibly "allow vaccine availability for emergency use in early 2021. (allianceforscience.org)
The disease can be easily prevented with two doses of the safe and efficient MMR vaccine. (fleetstreetclinic.com)
With this combination, doses of BCG vaccine as small as one tenth of a vial have been shown to be effective. (medscape.com)
IFN-alfa is well tolerated, and the lower doses of BCG vaccine are usually associated with decreased adverse effects. (medscape.com)

IMSEAR at SEARO: Deciphering the story of Bacillus Calmette Guerin (BCG) vaccine in prevention of leprosy. (who.int)
Prevention of flu disease caused by flu virus types A & B contained in the vaccine in adult & childn >6 mth. (mims.com)

The most extensive study ever conducted on the efficacy of the BCG vaccine for protection against tuberculosis, stratified by age and history of previous tuberculosis, was published in September in The Lancet Global Health . (medscape.com)
However, the efficacy of the BCG vaccine on those found to have tested positive for the Covid-19 virus need to be established by clinical trials, according to health department officials. (tribuneindia.com)

certolizumab pegol decreases effects of BCG vaccine live by pharmacodynamic antagonism. (medscape.com)
Second, the beneficial effects of BCG vaccine given at birth are "unlikely" to reduce the severity of COVID-19 decades later. (journosdiary.com)

They authors cite five reasons why countries should wait for the results of BCG vaccine randomised controlled trials. (journosdiary.com)

A vaccine containing bacillus Calmette-Guerin (BCG), an attenuated strain of Mycobacterium bovis, with non-specific immunoadjuvant and immunotherapeutic activities. (fpnotebook.com)
The BCG vaccine is an avirulent tuberculosis strain Mycobacterium bovis historically given to protect against tuberculosis and, since its introduction in 1921, has been the most widely administered vaccine in the history of medicine. (massgeneral.org)
The researchers wanted to know which kinds of immune cells respond to the BCG vaccine and "remember" the vaccine well enough to fight the Mycobacterium tuberculosis bacterium that causes TB. (lji.org)
Here we show that a live recombinant vaccine, rBCG30, which expresses large amounts of the Mycobacterium tuberculosis 30kDa major secretory protein, is more efficacious against bovine tuberculosis than BCG in the highly demanding guinea pig model of pulmonary tuberculosis. (escholarship.org)
BCG Vaccine is a live freeze-dried vaccine made from an attenuated strain of Mycobacterium bovis. (mysarkarinaukri.com)
Mycobacterium-derived OMVs are usually unstable and come in different sizes, making them unsuitable for vaccine applications. (financialexpress.com)

Given that a vaccine for the novel coronavirus is at least a year away, the World Health Organization(WHO) claimed that it is essential to understand if the BCG vaccine can reduce symptoms in those who have contracted COVID-19. (logically.ai)
I n a letter published in The Lancet on April 30, Director-General of World Health Organization Tedros A Ghebreyesus and others highlight a few critical issues surrounding the use of BCG vaccine for coronavirus disease (COVID-19). (journosdiary.com)
More than 160 vaccine efforts are currently underway in the global push to stop the COVID-19 pandemic, according to the World Health Organization. (allianceforscience.org)

On all the so-called vaccines "living" (those inoculated with the still active virus) - so polio in its version "drinkable" , or even measles-mumps-rubella. (rebelinkpress.com)
It can be given at a same time as DPT, DT, TT, measles, polio vaccines (OPV & IPV), Hepatitis-B and Yellow Fever vaccine. (mysarkarinaukri.com)
Across multiple studies reviewed, the effect of measles vaccine appears to be more beneficial to girls combating all-cause mortality when differences between vaccine effect in boys and girls was assessed. (immunizationevidence.org)
In a 2014 review of the non-specific effects of measles vaccines, among others, the WHO Strategic Advisory Group of Experts indicated that some studies of measles vaccine were suggestive (but not conclusive) of a beneficial effect of measles vaccine on overall mortality beyond the expected direct effect of the vaccine against measles. (immunizationevidence.org)
Another collaboration Merck is involved in uses an attenuated live measles vaccine. (allianceforscience.org)
While you take Tacrolimus you should not receive any live vaccines such as: flu vaccine through your nose, measles, mumps, rubella, polio by mouth, BCG (TB vaccine), yellow fever, chicken pox (varicella) and typhoid. (ikrispharmanetwork.com)

As of mid-April 2020, more than 115 vaccine candidates were in development. (bcg.com)
Importation and Circulation of Vaccine-Derived Poliovirus Serotype 2, Senegal, 2020-2021. (rsdjournal.org)

The ICMR is undertaking a study in Mumbai to evaluate whether the BCG (Bacille Calmette- Guerin) vaccine, primarily used against tuberculosis, is effective in preventing Covid-19 in elderly population, the city civic body said on Friday. (easternmirrornagaland.com)

Before 2012, Russian BCG-I (Bulbio, Sofia, Bulgaria) and Danish SSI 1331 strains were used (≈50% each). (cdc.gov)
After a change in BCG vaccine strains in Georgia to the exclusive use of BCG SSI vaccine, we found a substantial increase in the known prevalence of BCG-associated lymphadenitis. (cdc.gov)
We found 23 cases of BCG-associated lymphadenitis during a 19-month period, ≈4 times the number of reported cases during the prior 5 years, when multiple vaccine strains were used. (cdc.gov)
Not only when two different strains of BCG are inoculated in vitro, they modify the DNA of white blood cells for 14 months, but in addition, these strains modify the bone marrow which itself will generate future white blood cells. (rebelinkpress.com)
BCG-different strains, different vaccines? (ajtmh.org)
The 20th century dream of eradicating the global scourge of tuberculosis (TB) evaporated with the failure of the old BCG vaccine to protect the populations at greatest risk, low compliance at following the complicated and lengthy treatment in countries with limited resources, which was followed by the spread of multiple-drug resistant (MDR) strains. (intechopen.com)
But this can result in mutation of the influenza virus leading to an antigenic mismatch between the circulating reference and inactivated strains contained within the seasonal flu vaccine. (edu.au)
Professor Nolan said because cell-based flu vaccines, grown in animal cells, were designed to produce an exact match to the World Health Organization's selected influenza strains by avoiding egg-adapted changes, they could potentially provide greater effectiveness. (edu.au)

Croda emphasized that the findings from their study indicate that BCG vaccine protects against pulmonary tuberculosis and that those results differ from results of some previous studies. (medscape.com)
Every physician believes the BCG vaccine protects against serious forms of tuberculosis up to age 5. (medscape.com)
In the event of a new pandemic, will "covid type" one could imagine that BCG protects populations, the time to find a vaccine? (rebelinkpress.com)
The BCG (Bacillus Calmette-Guérin) vaccine protects against tuberculosis, which is also known as TB. (nhs.wales)
If you would like to learn more about the vaccine or the diseases it protects against, a number of information resources are available to help. (nhs.wales)
These will establish whether the vaccine actually protects against the virus in the real world. (allianceforscience.org)

The success rate of vaccine candidates is typically 10% or less from preclinical studies through clinical trials to licensure. (bcg.com)
authorities to carry out clinical trials of the vaccine," Dr Sanjay Mukherjee, Secretary, Medical Education and Drugs Department, Government of Maharashtra said. (tribuneindia.com)
Officials say, elderly patients and those with co-morbidities may be injected with newer versions of the BCG vaccine to protect them from the Covid-19 virus if the clinical trials are proved to be effective. (tribuneindia.com)
Bacillus Calmette-Guerin(BCG) vaccine that has been used for almost 100 years to prevent tuberculosis, is now being studied in clinical trials against COVID-19. (logically.ai)
In the absence of a validated animal model and/or an immune correlate which predict vaccine -mediated protection , large-scale clinical trials are currently the only option to prove efficacy of new tuberculosis candidate vaccines . (bvsalud.org)
This is a new technology: no adenovirus vector vaccines for other diseases are yet widely available, though vaccines for HIV, influenza, Ebola and malaria using this platform are in clinical trials and an Ebola vaccine has been briefly deployed. (allianceforscience.org)
INTERPRETATION: Further clinical trials assessing the aerosol route of vaccine delivery are merited for tuberculosis and other respiratory pathogens. (ox.ac.uk)
As of this writing, the vaccine is entering Phase II clinical trials. (allhealthsite.com)

When will an effective vaccine be available for COVID-19? (bcg.com)
According to experts, the only effective vaccine currently in use is the BCG vaccine and it contains a weakened form of the disease-causing bacterium. (financialexpress.com)
A more effective vaccine than BCG which does not provide complete protection from TB disease. (lstmed.ac.uk)

Medical chart abstraction was conducted for all infants with BCG lymphadenitis either reported to the NCTLD or found by inquiry of pediatricians at the largest children's hospital in the country during January 2012-July 2013. (cdc.gov)
BCG vaccine is given intradermally over the deltoid muscle on the left arm to infants within 5 days after birth at the maternity hospital. (cdc.gov)
A total of 14,230 live-born infants were registered at hospitals reporting BCG lymphadenitis in 2012. (cdc.gov)
A Swedish doctor, Carl Näslund, had also noted that infants vaccinated with BCG died two to three times less than the others. (rebelinkpress.com)
LA JOLLA-A long, long time ago, the BCG vaccine was approved for use against tuberculosis (TB), and it's still given to infants today. (lji.org)
BCG should be given routinely to all infants at risk of early exposure to the disease. (mysarkarinaukri.com)
The median age of the infants at presentation for birth vaccines was six (interquartile range 2-16) days. (annalsofglobalhealth.org)

Safety and immunogenicity of a candidate tuberculosis vaccine MVA85A delivered by aerosol in BCG-vaccinated healthy adults: a phase 1, double-blind, randomised controlled trial. (ox.ac.uk)

Shortly after a change to exclusive use of the Danish 1331 strain during 2012-2013, an increasing number of BCG-related lymphadenitis cases were reported to the National Center for Tuberculosis and Lung Diseases (NCTLD). (cdc.gov)
The BCG-vaccinated group also displayed protective effects against other infectious diseases, including fewer symptoms, lesser severity and fewer infectious disease events per patient. (massgeneral.org)
The results support the idea that BCG needs time to have a clinical effect, but its effects may then be very lasting and durable" says Hazel Dockrell, London School of Hygiene & Tropical Medicine, an infectious diseases expert who was not officially involved in the study. (massgeneral.org)
Vaccines are one of the most important ways to prevent children from getting some life-threatening diseases. (who.int)
The WHO website provides a list of certain diseases for which vaccines are available, and a list of some pathogens for which vaccines and/or monoclonal antibodies (mAbs) are in development. (technet-21.org)

BCG vaccine) of the immune response. (ugent.be)
These engineered adenoviruses, when put into a vaccine, trigger an immune response in the human body, protecting against COVID-19. (allianceforscience.org)
This motivated Rachit Agarwal, Assistant Professor at the Centre for BioSystems Science and Engineering (BSSE), IISc, and his team to develop a potential subunit vaccine candidate that contains only parts of the infectious bacterium to stimulate an immune response. (financialexpress.com)
The research found the cell-based quadrivalent influenza vaccine (QIVc) produced a sufficient immune response in children aged two to 18 years. (edu.au)

Throw away from bcg vaccine if you do not required to you are attractive for research institute in southern denmark, she has latent pulmonary disease? (malamahealth.online)

BACKGROUND: Intradermal MVA85A, a candidate vaccine against tuberculosis, induces high amounts of Ag85A-specific CD4 T cells in adults who have already received the BCG vaccine, but aerosol delivery of this vaccine might offer immunological and logistical advantages. (ox.ac.uk)
We did a phase 1 double-blind trial to compare the safety and immunogenicity of aerosol-administered and intradermally administered MVA85A METHODS: In this phase 1, double-blind, proof-of-concept trial, 24 eligible BCG-vaccinated healthy UK adults were randomly allocated (1:1) by sequentially numbered, sealed, opaque envelopes into two groups: aerosol MVA85A and intradermal saline placebo or intradermal MVA85A and aerosol saline placebo. (ox.ac.uk)

A cell-based influenza vaccine has effectively provided protection against the flu in children and adolescents, according to a new study. (edu.au)
The findings, published in The New England Journal of Medicine , were the first on the absolute efficacy of a cell-based influenza vaccine in children as young as two years of age. (edu.au)
The overall vaccine efficacy was 54.6 per cent, meeting the pre-specified endpoint for success and showing benefit across three influenza seasons and all eight countries. (edu.au)
QIVc uses a cell-based flu vaccine production process, an alternative to traditional egg-based manufacturing where reference influenza viruses are grown in the yolk of fertilised hens eggs. (edu.au)
Professor Nolan said cell-based vaccine technology may also offer additional advantages including increased scalability and production speed in the event of an influenza pandemic. (edu.au)

Bacillus Calmette-Guérin (BCG) vaccine is one of the most commonly used vaccines for tuberculosis (TB) worldwide ( 1 ). (cdc.gov)
This report updates and replaces previous recommendations regarding the use of Bacillus of Calmette and Guerin (BCG) vaccine for controlling tuberculosis (TB) in the United States (MMWR 1988;37:663-4, 669-75). (cdc.gov)
C57BL/6 mice were immunized with Bacillus Calmette-Guérin ( BCG ) and growth inhibition of mycobacteria by splenocytes was assessed. (bvsalud.org)
Intravesical Bacillus Calmette-Guerin ( BCG ) vaccine is the mainstay of treatment and prophylaxis in superficial bladder cancer (SBC) as it reduces tumor recurrence and disease progression. (bvsalud.org)
Bacillus Calmette-Guérin ( BCG ) is the most common intravesical agent used to treat carcinoma in situ (CIS). (medscape.com)
No evidence suggests that these adjuvant therapies are as effective as bacillus Calmette-Guérin (BCG). (medscape.com)
The therapeutic efficacy of Bacillus calmette-guerin substrain russian BCG-I live antigen can be decreased when used in combination with TMC-310911. (drugbank.com)

The aim of this study was to determine the efficacy of intravesical gemcitabine in patients with BCG -refractory SBC. (bvsalud.org)
refractory (after at least 2 courses of intravesical BCG ) or intolerant to intravesical BCG therapy were included. (bvsalud.org)
An ongoing shortage of BCG in the United States has necessitated the development of strategies to prioritize use of intravesical BCG and identify alternatives for some patients. (medscape.com)

The need to generate clinical data to demonstrate safety and efficacy, combined with the need to reach global manufacturing scale, mean that producing a vaccine in the necessary amounts will probably not be possible for at least 12 to 18 months-and this is a best-case timeline-or the second to fourth quarters of 2021. (bcg.com)

This kind of broad pipeline is critical, given that infectious disease vaccines typically achieve end-to-end success rates of less than 10% and may have different safety and efficacy profiles in different subpopulations. (bcg.com)

In all cases, a 0.05-mL dose of Danish SSI BCG vaccine (series 111003A and 111021A) was used. (cdc.gov)
BCG is also one of the most affordable medicines, costing less than a dollar a dose in many parts of the world. (massgeneral.org)
The first dose was given one hundred years ago this year," says La Jolla Institute for Immunology (LJI) Research Assistant Professor Cecilia Lindestam Arlehamn, Ph.D. "Technology has moved on since then, but not the tuberculosis vaccine, although there are many promising candidates in the pipeline. (lji.org)
Only one dose of the BCG Vaccine is required. (nhs.wales)
Double dose of bcg should not cause any problem to the child. (practo.com)
Iis it because of double dose of bcg. (practo.com)
Double dose of bcg given my new born. (practo.com)
As usual, before the child receives the day's dose of vaccines, she is undressed for weighing by the assistant nurses in attendance. (who.int)
One option is splitting the dose of BCG so that multiple patients may be treated using a single vial. (medscape.com)
National Comprehensive Cancer Network (NCCN) guidelines recommend that a one-half or one-third dose may be considered for BCG induction and should be used for BCG maintenance, if supply allows. (medscape.com)
Two weeks into this nightmare, I received a phone call from a doctor at the Naval Hospital, informing me that there had been a mistake, and both of the boys had received the ADULT dose of the flu vaccine. (followingvaccinations.com)

The original BCG strain was developed in 1921. (cdc.gov)
Compared with the parental wild-type BCG strain, rBCG30 administered intradermally induced significantly greater cell-mediated and humoral immune responses against the 30kDa protein, as determined by measuring cutaneous delayed-type hypersensitivity and antibody titers. (escholarship.org)
The only BCG approved for use in the United States is the Tice strain. (medscape.com)

VoICE is a project of the International Vaccine Access Center at the Johns Hopkins Bloomberg School of Public Health, and is made possible with support from the Bill & Melinda Gates Foundation. (immunizationevidence.org)

BCG vaccine is administered via the intradermal route. (edu.au)
MVA-specific cellular responses were detected in both groups, whereas serum antibodies to MVA were only detectable after intradermal administration of the vaccine. (ox.ac.uk)

By looking at this immune signature, vaccine developers can make sure their TB vaccine candidates are enlisting the right kinds of immune cells. (lji.org)
BCG Vaccine Laboratory selection will be done on the basis of test/interview and shortlisted candidates will be appointed at Tamil Nadu. (mysarkarinaukri.com)
The BCG Vaccine Laboratory Chennai, offers career opportunities for the eligible candidates , they offers recruitment for the posts of, Deputy Assistant (Medical)/ Refrigeration Engineer / Junior Technical Officer / Assistant Technical Officer / Administrative Officer / Junior Accounts Officer / Veterinary Assistant Surgeon / Statistical Investigator Grade / Scientific Assistant / Senior Laboratory Assistant / Store keeper / upper Division Clerk / Lab Attendant / Lab Peon / Office Peon / Sweeper, etc. (mysarkarinaukri.com)
Tuberculosis vaccine candidates are entering clinical studies in areas where BCG fails. (nih.gov)
What are the Top 5 most promising COVID-19 vaccine candidates? (allianceforscience.org)
A detailed list of marketed and pipeline vaccine candidates that are anticipated to be developed in combination with novel vaccine delivery devices in the near future. (talkitter.com)

Adenoviruses are not the only viral vectors that can be used: pharmaceutical giant Merck says it is working on a potential COVID vaccine using an engineered vesicular stomatis virus , previously used successfully in its Ebola vaccine. (allianceforscience.org)
Maybe I'd read an article about how Merck is getting sued for something about vaccines, and then wondering whether vaccines are safe. (skepticalraptor.com)

Perhaps ironically, uncertainty about the availability of a COVID-19 vaccine is heightened because, as the incidence of disease declines (because of social distancing and other measures), rapid testing becomes more challenging. (bcg.com)
TB skin tests and TB blood tests are not expected to affect the safety or the effectiveness of the COVID-19 vaccine. (cdc.gov)

However, the only currently available vaccine, M. bovis Bacille Calmette-Guerin (BCG), is not highly efficacious. (escholarship.org)
As rBCG30 is significantly more potent than BCG against M. bovis challenge, it has potential as a vaccine against bovine tuberculosis in domesticated animals and in wild animal reservoirs. (escholarship.org)
M. bovis BCG-Denmark (Danish 1331) (Green Signal Biopharma, India), 4 and 5: MGIT culture-positive and MPT64-negative samples, Lane M: 100-bp DNA ladder. (ajtmh.org)
C ) Multiple sequence alignment of the discriminatory regions in the gyrB gene between M. bovis and M. bovis BCG and other members of the MTBC. (ajtmh.org)
E ) Schematic representation of RD1 and RD4 PCR amplification band sizes for differentially identifying M. bovis BCG and M. tuberculosis and M. bovis . (ajtmh.org)

The BCG vaccine is used universally across India to immunise children against tuberculosis and meningitis. (tribuneindia.com)
In its application to the Indian Council of Medical Research (ICMR) and the Drugs Controller of India, the Haffkine Institute has claimed that preliminary research on the BCG vaccine's effect in combating the Covid-19 virus has been encouraging. (tribuneindia.com)
DR. T.F. HASSAN CHIEF MEDICAL OFFICER (SAG) Director & Public Information Officer, BCG Vaccine Laboratory, (Government of India), Guindy, Chennai-600 032. (mysarkarinaukri.com)
She has had her BCG vaccine in India. (ndtv.com)

The IFN-alfa up-regulates the major histocompatibility complex/BCG vaccine antigen complex, which enhances the immunologic response. (medscape.com)

Misleading: The BCG vaccine works against the novel coronavirus. (logically.ai)
The BCG vaccine works against the novel coronavirus. (logically.ai)

Professor Nigel Curtis is leading an international randomised controlled trial, known as the BRACE trial, to determine the effectiveness of Bacille Calmette-Guérin (BCG) vaccine in reducing incidence and severity of COVID-19 in healthcare workers. (edu.au)
Although there is no proven link yet, the BCG vaccine is being studied to see if it can help reduce the prevalence and severity of COVID-19 symptoms. (logically.ai)
Currently, randomised controlled trials using BCG vaccine are under way in the Netherlands and Australia to assess whether the vaccine can reduce the incidence and severity of COVID-19 in health-care workers. (journosdiary.com)
The primary outcome was safety, assessed by the frequency and severity of vaccine-related local and systemic adverse events. (ox.ac.uk)

No BCG-related systemic adverse events occurred. (massgeneral.org)

Despite all this, "health authorities" continue to push the jabs on everyone, including children, even though untold thousands of people are suffering and dying from vaccine adverse effects. (naturalnews.com)

The 144 adult type diabetics (96 BGC treated and 48 placebo) analyzed in the COVID-19 trial were part of an ongoing Phase IIb clinical trial testing BCG as a treatment for adults with established type 1 diabetes. (massgeneral.org)
For the study, Lindestam Arlehamn and her colleagues followed a group of 17 adults in Sweden who had never received a BCG vaccine or contracted tuberculosis. (lji.org)
Although the BCG vaccine works well in children, it is not as effective at protecting adolescents and adults, scientists claim. (financialexpress.com)
There has been a recent candidate vaccine developed by a big pharmaceutical company that has shown considerable promise, with close to 50% effectiveness in adults. (cdc.gov)

Tedros and others caution that using BCG vaccine on health-care workers for COVID-19 should be only after safety and efficacy are tested through randomised controlled trials. (journosdiary.com)
They underscore the importance of carrying out randomised controlled trials using the vaccine to understand the safety and efficacy before using it on health-care workers. (journosdiary.com)

Cholera and typhoid vaccines were first developed. (timetoast.com)

The purpose of this work was to study the diagnostic and therapeutic features in children vaccinated with BCG. (ajol.info)
The BCG vaccine is now only offered to babies up to 1 year old and unvaccinated children aged one to five years who are more likely to spend time with someone with TB. (nhs.wales)
And finally, using the vaccine without evidence of its benefits could further jeopardise vaccine supply, which is already in short supply, to protect children against disseminated TB in high-risk countries. (journosdiary.com)
In the autumn of 1901, nine children in Camden, New Jersey, died from tainted smallpox vaccine. (timetoast.com)
Whatever the cause may be, there are enough people who have seen their children decline after receiving a vaccine that we cannot all be wrong. (followingvaccinations.com)

That's why British scientists have begun testing the 1921 vaccine Bacille Calmette-Guérin (BCG). (briardforce.com)

Rodriguez et al reported in vitro evidence that a recombinant BCG (rBCG-S1PT) demonstrated an improved immune activation profile compared with wild type BCG. (medscape.com)

In addition, new information about the protective efficacy of BCG has become available. (cdc.gov)
So the protective effect of BCG against COVID-19 is a biologically plausible hypothesis," Prof. Gagandeep Kang, executive director of the Translational Health Science and Technology Institute (THSTI), Faridabad had earlier told The Hindu . (journosdiary.com)

Anatomy3

Organisms5

Diseases8

Chemicals and Drugs63

Analytical, Diagnostic and Therapeutic Techniques and Equipment9

Phenomena and Processes5

Named Groups1

Health Care3

Geographicals1

Advances in the biological therapy and gene therapy of malignant disease. (1/1802)

Characterization of the culture filtrate-specific cytotoxic T lymphocyte response induced by Bacillus Calmette-Guerin vaccination in H-2b mice. (2/1802)

Influences of Kupffer cell stimulation and suppression on immunological liver injury in mice. (3/1802)

Differential protective efficacy of DNA vaccines expressing secreted proteins of Mycobacterium tuberculosis. (4/1802)

Vaccinated mice remain more susceptible to Mycobacterium tuberculosis infection initiated via the respiratory route than via the intravenous route. (5/1802)

Skin reaction and antibody responses in guinea-pigs sensitized to human leukaemia cells or their nuclei in combination with Bacillus Calmette-Guerin. (6/1802)

The association between CD2+ peripheral blood lymphocyte subsets and the relapse of bladder cancer in prophylactically BCG-treated patients. (7/1802)

Childhood immunization coverage in zone 3 of Dhaka City: the challenge of reaching impoverished households in urban Bangladesh. (8/1802)

BCG Vaccine

Mycobacterium bovis

Vaccines

Tuberculosis Vaccines

Vaccines, Synthetic

Vaccines, Inactivated

Vaccination

Tuberculosis

Viral Vaccines

Tuberculin Test

Vaccines, DNA

Vaccines, Combined

Bacterial Vaccines

Mycobacterium tuberculosis

International System of Units

AIDS Vaccines

Guinea-Bissau

Vaccines, Subunit

Vaccines, Conjugate

Immunization, Secondary

Tuberculosis, Pulmonary

Tuberculosis, Miliary

Lymphadenitis

Tuberculosis, Meningeal

Malaria Vaccines

Adjuvants, Immunologic

Papillomavirus Vaccines

Antigens, Bacterial

Meningococcal Vaccines

Tuberculin

Hypersensitivity, Delayed

Vaccines, Attenuated

Hepatitis B Vaccines

Measles Vaccine

Pertussis Vaccine

Mice, Inbred BALB C

Haemophilus Vaccines

Interferon-gamma

Poliovirus Vaccine, Inactivated

Rabies Vaccines

Rotavirus Vaccines

Leprosy

Cholera Vaccines

Guinea Pigs

Immunity, Cellular

Lactoferrin

Smallpox Vaccine

Typhoid-Paratyphoid Vaccines

Diphtheria-Tetanus-Pertussis Vaccine

Antibodies, Viral

Spleen

Mice, Inbred C57BL

Chickenpox Vaccine

Immunization Schedule

Infant, Newborn

Mumps Vaccine

Bacterial Proteins

Hepatitis A Vaccines

Measles-Mumps-Rubella Vaccine

Streptococcal Vaccines

Immunization

Anthrax Vaccines

Dengue Vaccines

Vaccines, Virosome

Antibodies, Bacterial

Virulence

T-Lymphocytes

Lung

Poliovirus Vaccine, Oral

Viral Hepatitis Vaccines

Yellow Fever Vaccine

Plague Vaccine

Fungal Vaccines

Rubella Vaccine

Genome, Bacterial

Vaccines, Acellular

SAIDS Vaccines

Salmonella Vaccines

Vaccines, Virus-Like Particle

Ebola Vaccines