Polycyclic Hydrocarbons, Aromatic
Bay-Region, Polycyclic Aromatic Hydrocarbon
Phenanthrenes
Benzo(a)pyrene
Hydrocarbons
Creosote
Benz(a)Anthracenes
Hydrocarbons, Aromatic
Carcinogens
Receptors, Aryl Hydrocarbon
DNA Adducts
Benzopyrenes
Soil Pollutants
Coal Tar
Cytochrome P-450 CYP1A1
Biodegradation, Environmental
Environmental Monitoring
Epoxy Compounds
Acenaphthenes
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
Air Pollutants
Water Pollutants, Chemical
Petroleum
Mutagens
Air Pollutants, Occupational
Environmental Pollutants
Metabolic Detoxication, Phase II
Bays
Tetrachlorodibenzodioxin
Occupational Exposure
Coal
Stereoisomerism
Biotransformation
Vehicle Emissions
Dihydroxydihydrobenzopyrenes
Chromatography, High Pressure Liquid
Aryl Hydrocarbon Hydroxylases
Environmental Exposure
Hydrocarbons, Halogenated
Particulate Matter
Mutagenicity Tests
Gas Chromatography-Mass Spectrometry
Metallurgy
Fuel Oils
Cooking
Naphthalenes
Dioxins
Geologic Sediments
9,10-Dimethyl-1,2-benzanthracene
Benzoflavones
Sphingomonas
Structure-Activity Relationship
Inhalation Exposure
Gulf of Mexico
Soil Microbiology
Incineration
Aryl Hydrocarbon Receptor Nuclear Translocator
Naphthols
beta-Naphthoflavone
Steel
Hydrocarbons, Chlorinated
Dominican Republic
Dioxygenases
Cytochrome P-450 Enzyme System
Polychlorinated Biphenyls
Glutathione Transferase
Gasoline
Industry
Smoke
Hazardous Waste
Fundulidae
Alkanes
Enzyme Induction
Poland
Metabolic Detoxication, Drug
Maternal Exposure
Environmental Pollution
Astronomy
Benzene
Xenobiotics
Cytochrome P-450 CYP1A2
Ilex paraguariensis
Epoxide Hydrolases
Water Pollution, Chemical
Biological Markers
New York City
Oxygenases
Complex Mixtures
Nitro Compounds
Mycobacterium
Organic Chemicals
Heating
DNA Damage
Molecular Structure
Molecular Sequence Data
7-Alkoxycoumarin O-Dealkylase
Fossil Fuels
Azacosterol
Soil
Aluminum
Environmental Remediation
Extraction and Processing Industry
Mice, Inbred SENCAR
Glucuronates
Nitrosamines
Astronomical Phenomena
Maximum Allowable Concentration
Quinones
Basidiomycota
DNA
Carbon
RNA, Ribosomal, 16S
Water Pollutants
Heterocyclic Compounds
Bacteria
Amines
Prostaglandins A, Synthetic
Industrial Waste
Water Microbiology
Oxidation-Reduction
Pseudomonas putida
Wood
Seasons
Xylenes
Soot
Rhizophoraceae
Solid Phase Extraction
Prenatal Exposure Delayed Effects
Case-Control Studies
Graphite
Glutathione S-Transferase pi
Gases
Charcoal
Mineral Oil
Tars
Air Pollution
Rivers
Chromatography, Gas
Polymorphism, Genetic
Phosphorus Radioisotopes
Glycine N-Methyltransferase
Liver
Metals, Heavy
Cotinine
Pesticide Residues
Microsomes, Liver
Lung
Benzene Derivatives
Dose-Response Relationship, Drug
DNA, Ribosomal
Comet Assay
Lead Radioisotopes
Risk Assessment
Solid Phase Microextraction
Sequence Analysis, DNA
Air
Pregnancy
Oxidoreductases
Pesticides
Vapor Pressure
Toxicity Tests
Gram-Negative Aerobic Bacteria
Atmosphere
Manufactured Materials
Fishes
Rubber
Lakes
Benzopyrene Hydroxylase
Fires
3-alpha-Hydroxysteroid Dehydrogenase (B-Specific)
Polycyclic aromatic hydrocarbons with bay-like regions inhibited gap junctional intercellular communication and stimulated MAPK activity. (1/8)
Many polycyclic aromatic hydrocarbons (PAHs) are known carcinogens. A considerable amount of research has been devoted to predicting the genotoxic, tumor-initiating potential of PAHs based on chemical structure. However, information on the correlation of structure with the non-genetoxic, epigenetic events of tumor promotion is sparse. PAHs containing a bay or bay-like region were shown to be potent inhibitors of gap-junctional intercellular communication (GJIC), an epigenetic event involved in the removal of an initiated cell from growth suppression. We tested the epigenetic toxicity of PAHs containing bay-like regions by comparing the effects of methylated vs. chlorinated isomers of anthracene on the temporal activation of mitogen-activated protein kinase (MAPK) and the regulation of GJIC. Specifically, we used anthracene, 1-methylanthracene, 2-methylanthracene, 9-methylanthracene, 9,10-dimethylanthracene, 1-chloroanthracene, 2-chloroanthracene, and 9-chloroanthracene. We determined the effect of these compounds on GJIC and on the activation of extracellular receptor kinase (ERK 1 and 2), a MAPK, in F344 rat liver epithelial cells. Results showed that bay or bay-like regions, formed by either chlorine or a methyl group, reversibly inhibited GJIC at the same doses, time, and time of recovery, whereas the linear-planar isomers had no effect on GJIC. Similarly, the GJIC-inhibitory isomers also induced the phosphorylation of ERK 1 and ERK 2, while the non-inhibitory isomers had no effect on the activation of these MAPKs. MAPK activation occurred 10-20 min after the inhibition of GJIC, which indicates that MAPK is not involved in the initial regulation of GJIC; instead altered GJIC may be affecting MAPK activation. The present study revealed that there are structural determinants of PAHs, which clearly affect epigenetic events known to be involved in the non-genetoxic steps of tumor promotion. These events are the release of a cell from growth suppression involving the reduction of GJIC, followed by the activation of intracellular mitogenic events. (+info)Three-dimensional structure of anti-5,6-dimethylchrysene-1, 2-dihydrodiol-3,4-epoxide: a diol epoxide with a bay region methyl group. (2/8)
The three-dimensional structure of a dihydrodiol epoxide of 5, 6-dimethylchrysene was elucidated by X-ray diffraction techniques. The effects of the steric overcrowding by the 5-methyl group in the bay region of this compound are described. The carbon atom of the 5-methyl group is found to lie out of the plane of the aromatic system, thereby avoiding the nearer C-H group of the epoxide ring; this C-H hydrogen atom is pushed in the opposite direction. As a result, the molecule is distorted so that the relative orientations of the epoxide group and the aromatic ring systems are very different for the diol epoxides of (nearly planar) benzo[a]pyrene (studied by Neidle and co-workers) and (distorted) 5, 6-dimethylchrysene (described here). The main effect of the 5-methyl group is to change the relative angle between the epoxide-bearing ring (the site of attack when the diol epoxide acts as an alkylating agent) and the aromatic ring system (which is presumed to lie partially between the DNA bases in the DNA adduct that is about to be formed). This may favor some specific alkylation geometry. (+info)Tumorigenicity of four optically active bay-region 3,4-diol 1, 2-epoxides and other derivatives of the nitrogen heterocycle dibenz[c,h]acridine on mouse skin and in newborn mice. (3/8)
The nitrogen heterocycle dibenz[c,h]acridine (DB[c,h]ACR) and the enantiomers of the diastereomeric pair of bay-region 3,4-diol 1, 2-epoxides as well as other bay-region epoxides and dihydrodiol derivatives of this hydrocarbon have been evaluated for tumorigenicity on mouse skin and in the newborn mouse. On mouse skin, a single topical application of 50 or 200 nmol of compound was followed 10 days later by twice-weekly applications of the tumor promoter 12-O:-tetradecanoylphorbol-13-acetate for 20 weeks. DB[c, h]ACR and the four optically pure, bay-region 3,4-diol-1,2-epoxide isomers all had significant tumor- initiating activity. The isomer with (1R,2S,3S,4R) absolute configuration [(+)-DE-2] was the most active diol epoxide isomer. The (-)-(3R,4R)-dihydrodiol of DB[c, h]ACR, the expected metabolic precursor of the bay-region (+)-DE-2, was 4- to 6-fold more tumorigenic than its corresponding (+)-enantiomer. In tumorigenicity studies in newborn mice, a total dose of 70-175 nmol of DB[c,h]ACR or one of its derivatives was injected i.p. on days 1, 8 and 15 of life, and tumorigenic activity was determined when the mice were 36-39 weeks old. DB[c,h]ACR produced a significant number of pulmonary tumors and also produced hepatic tumors in male mice. Of the four optically active bay-region diol epoxides, only (+)-DE-2 and (+)-DE-1 with (1R,2S,3S,4R) and (1S, 2R,3S,4R) absolute configuration, respectively, produced a significant tumor incidence. At an equivalent dose, the (+)-DE-2 isomer produced several-fold more pulmonary tumors and hepatic tumors than the (+)-DE-1 isomer. The (-)-(3R,4R)-dihydrodiol, metabolic precursor of the bay-region (+)-DE-2, was strongly active and induced an equal number of pulmonary and hepatic tumors as did DB[c,h]ACR. The (+)-(3S,4S) dihydrodiol was less active. The bay-region (+)-(1R,2S)-epoxide of 1,2,3,4-tetrahydro DB[c,h]ACR was strongly tumorigenic in newborn mice whereas its (-)-(1S, 2R)-enantiomer was inactive. This contrasts with the data on mouse skin where both enantiomers had substantial tumorigenic activity. In summary, the bay-region (+)-(1R,2S,3S,4R)-3,4-diol 1,2-epoxide of DB[c,h]ACR was the most tumorigenic of the four optically active bay-region diol epoxides of DB[c,h]ACR on mouse skin and in the newborn mouse. These results with a nitrogen heterocycle are similar to earlier data indicating high tumorigenic activity for the R,S,S,R bay-region diol epoxides of several carbocyclic polycyclic aromatic hydrocarbons. (+info)Preferential glutathione conjugation of a reverse diol epoxide compared to a bay region diol epoxide of phenanthrene in human hepatocytes: relevance to molecular epidemiology studies of glutathione-s-transferase polymorphisms and cancer. (4/8)
(+info)Studies of the binding of diolepoxide metabolites of polycyclic aromatic hydrocarbons to DNA using electrofluorescence polarization spectroscopy. (5/8)
In the electrofluorescence method, a solution of DNA with covalently bound polycyclic hydrocarbons is placed in an electric field, and changes in the intensity of polarized fluorescence are observed. Under the correct conditions, these charges can be used to determine a value for the angle psi between the long axis of the hydrocarbon molecule and the axis of the DNA helix. For DNA or poly(dA-dT) treated with each stereoisomer of anti-benzo[c]phenanthrene diolepoxide, psi ranged from 55 degrees to 61 degrees, consistent with a mixture of quasi-intercalated adenine adducts and externally bound guanine adducts. Similar results were obtained with another set of 'fjord-region' diolepoxides, derived from benzo[c]chrysene. Adducts in DNA treated with diolepoxides derived from chrysene, 5-methylchrysene or 6-methylchrysene gave psi of about 53 degrees, so the predominant adducts are externally bound, probably in the minor groove of DNA. (+info)Bay or baylike regions of polycyclic aromatic hydrocarbons were potent inhibitors of Gap junctional intercellular communication. (6/8)
Many polycyclic aromatic hydrocarbons (PAHs) are known carcinogens, and a considerable amount of research has been devoted to predicting the tumor-initiating potential of PAHs based on chemical structure. However, there has been little research into the effects of PAHs on the epigenetic events of tumor promotion and no structural correlation has been made thereof. Gap junctional intercellular communication (GJIC) activity was used in this study as an epigenetic biomarker to determine the structure-activity relationships of twelve different PAHs. The PAHs used were naphthalene, 1-methylnaphthalene, 2-methylnaphthalene, anthracene, 1-methylanthracene, 2-methylanthracene, 9-methylanthracene, 9, 10-dimethylanthracene, phenanthrene, fluorene, 1-methylfluorene, and fluoranthene. Results showed that PAHs containing bay or baylike regions inhibited GJIC more than did the linear PAHs. The nonnaphthalene PAHs were not cytotoxic as determined by a vital dye uptake assay, but the naphthalene compounds were cytotoxic at the higher doses, indicating that the down regulation of GJIC by these naphthalenes could be a consequence of general membrane damage. Inhibition of GJIC by all the inhibitory PAHs was reversed when the cells were refreshed with PAH-free growth medium. Inhibition of GJIC occurred within 0.5-5 min and correlated with the aqueous solubility of the PAHs. The present study revealed that there are structural determinants of epigenetic toxicity as determined by GJIC activity. (+info)Comparative mouse skin tumorigenicity and induction of Ha-ras mutations by bay region diol epoxides of 5-methylchrysene and 5,6-dimethylchrysene. (7/8)
We compared the tumor-initiating activities toward mouse skin of two structurally related polycyclic aromatic hydrocarbon diol epoxides: racemic anti-1,2,3,4-tetrahydro-5,6-dimethylchrysene-1,2-diol-3,4-epoxide (5,6-diMeCDE) and racemic anti-1,2,3,4-tetrahydro-5-methylchrysene-1,2-diol-3,4-epoxide (5-MeCDE). Tumors induced by these diol epoxides were analysed for mutations in the Ha-ras gene. 5,6-diMeCDE is derived from the non-planar parent compound 5,6-dimethylchrysene, and reacts to approximately equal extents with dA and dG in DNA, whereas 5-MeCDE is derived from a nearly planar parent compound, 5-methylchrysene, and reacts mainly with dG in DNA. 5,6-diMeCDE, at initiating doses of 33, 100 or 400 nmol per mouse, induced 1.2, 2.2 and 6.2 skin tumors per mouse, respectively. It was significantly less tumorigenic than 5-MeCDE which induced 3.1, 7.5 and 9.1 skin tumors per mouse at the same doses. Tumors induced by 5,6-diMeCDE had a large number of CAA-->CTA mutations in codon 61 of the Ha-ras gene: 50, 55 and 75% of the tumors analysed had this mutation at the 33, 100 and 400 nmol doses. No mutations were found in codons 12 and 13 in the tumors induced by 5,6-diMeCDE. In contrast, CAA-->CTA mutations in codon 61 were rarely seen in tumors induced by 5-MeCDE. At the highest dose of 5-MeCDE, 20% of the tumors analysed had mutations at G of codons 12 and 13. The results of this comparative study support the hypothesis that mutations in the Ha-ras gene in mouse skin tumors induced by PAH diol epoxides occur as a result of their direct reaction with the gene. However, pathways other than the commonly observed Ha-ras codon 61 mutations are clearly important in mouse skin tumorigenesis by these diol epoxides. (+info)Detoxification of optically active bay- and fjord-region polycyclic aromatic hydrocarbon dihydrodiol epoxides by human glutathione transferase P1-1 expressed in Chinese hamster V79 cells. (8/8)
Dihydrodiol epoxides (DEs) are important carcinogenic metabolites of polycyclic aromatic hydrocarbons (PAHs). The metabolic formation of four stereoisomeric DEs (a pair of optically active diastereomers termed as syn- and anti-form) is possible. Glutathione tranferases (GSTs) have been demonstrated to catalyze the detoxification of DEs. Purified GSTs display remarkable differences in catalytic efficiencies towards bay- and fjord-region DEs along with a high degree of regio- and stereoselectivity. Here we determined to which extent heterologously expressed human GSTP1-1, a major GST isoform in lung, affects the mutagenicity of stereoisomeric bay-region DEs of benzo[a]pyrene in Chinese hamster V79 cells. To evaluate the influence of sterical crowding in the substrate on the activity of GSTP-1, the study was extended to the strongly mutagenic fjord-region (-)-anti-DEs of benzo[c]phenanthrene and dibenzo[a,l]pyrene. GSTP1-1,reduced preferentially the mutagenicity (studied at the hprt locus) of (+)-anti and (+)-syn-DEs of benzo[a]pyrene (by 66 and 67%) as compared with the corresponding (-)-anti- and (-)-syn-enantiomers (by 15 and 13%). These results are in line with previous studies on the enantioselectivity of purified GSTP1-1 towards the DE isomers of benzo[a]pyrene and benzo[c]phenanthrene showing that enantiomers with (R)-configuration at the benzylic oxiranyl carbon are better substrates than those with (S)-configuration. Interestingly, the (-)-anti-DEs of benzo[c]phenanthrene and dibenzo[a,l]pyrene were efficiently detoxified by GSTP-1-1 in the constructed cell line (reduction of mutagenicity by 66 and 64%). This study demonstrates that differences in the caalytic activity seen for purified GST towards individual mutagens do not necessarily reflect the detoxification of DEs by the same enzyme in a living cell and provides further evidence that specific human GSTs play a role in the detoxification of DEs of PAHs. (+info)In the medical field, "Polycyclic Hydrocarbons, Aromatic" refers to a group of organic compounds that are composed of multiple fused aromatic rings of carbon atoms. These compounds are commonly found in a variety of environmental sources, including tobacco smoke, diesel exhaust, and certain types of industrial emissions. Polycyclic aromatic hydrocarbons (PAHs) are known to be toxic and carcinogenic, meaning they have the potential to cause cancer in humans. They can also cause a range of other health problems, including respiratory issues, skin irritation, and damage to the liver and kidneys. In the medical field, PAHs are often studied as potential environmental pollutants and as potential risk factors for certain types of cancer, such as lung cancer and bladder cancer. They may also be used as markers of exposure to environmental pollutants in epidemiological studies.
In the medical field, polycyclic compounds are organic compounds that consist of two or more fused aromatic rings. These compounds are often found in nature and are known for their complex structures and diverse biological activities. Polycyclic compounds can be classified into several categories based on their structure, including polycyclic aromatic hydrocarbons (PAHs), heterocyclic compounds, and fused-ring systems. PAHs are compounds that contain multiple aromatic rings, typically with a carbon skeleton, and are known for their carcinogenic properties. Heterocyclic compounds contain at least one heteroatom (such as nitrogen, oxygen, or sulfur) in addition to carbon, and are often used as pharmaceuticals or as intermediates in the synthesis of other drugs. Fused-ring systems are compounds that consist of two or more rings that are fused together, and are often used as dyes or pigments. Polycyclic compounds can have a wide range of biological activities, including anti-inflammatory, anti-cancer, and anti-microbial properties. They are also used in the development of new drugs and as research tools to study the mechanisms of various diseases. However, some polycyclic compounds can be toxic or carcinogenic, and their use must be carefully monitored to minimize potential risks.
I'm sorry, but I couldn't find any information on a medical term called "Chrysenes." It's possible that you may have misspelled the term or that it is not a commonly used term in the medical field. If you could provide more context or information about where you heard or saw this term, I may be able to assist you further.
Bay-Region, Polycyclic Aromatic Hydrocarbon (PAH) refers to a group of organic compounds that are formed during the incomplete combustion of organic materials such as coal, oil, and wood. These compounds are composed of multiple fused aromatic rings and are known to be potent carcinogens. In the medical field, exposure to Bay-Region PAHs has been linked to an increased risk of various types of cancer, including lung cancer, bladder cancer, and liver cancer. These compounds can also cause DNA damage and disrupt normal cellular processes, leading to the development of cancer. Exposure to Bay-Region PAHs can occur through various routes, including inhalation of contaminated air, ingestion of contaminated food or water, and skin contact with contaminated materials. The risk of exposure to these compounds can be reduced through measures such as using protective equipment when handling contaminated materials, avoiding exposure to smoke and other sources of air pollution, and consuming a healthy diet.
Phenanthrenes are a class of organic compounds that contain a six-membered aromatic ring with two additional fused six-membered rings. They are commonly found in coal tar and are known for their mutagenic and carcinogenic properties. In the medical field, phenanthrenes have been studied for their potential use as anti-inflammatory agents, antioxidants, and anticancer drugs. Some specific examples of phenanthrene derivatives that have been studied for their medicinal properties include phenanthrenequinone, phenanthrene-9-one, and 9,10-phenanthrenequinone. However, due to their potential toxicity, the use of phenanthrenes in medicine is limited and further research is needed to fully understand their potential risks and benefits.
I'm sorry, but I couldn't find any specific medical term or definition related to "Pyrenes." It's possible that you may have misspelled the word or that it is not commonly used in the medical field. If you could provide more context or information about where you heard or saw this term, I may be able to provide a more accurate answer.
In the medical field, hydrocarbons are organic compounds that consist solely of hydrogen and carbon atoms. They are commonly found in various substances, including fossil fuels, crude oil, and natural gas. Hydrocarbons can be classified into two main categories: aliphatic hydrocarbons and aromatic hydrocarbons. Aliphatic hydrocarbons are those that do not contain any benzene rings, while aromatic hydrocarbons contain one or more benzene rings. In medicine, hydrocarbons are used in a variety of applications, including as solvents, lubricants, and as components in medications. Some hydrocarbons, such as benzene, are known to be toxic and can cause cancer and other health problems when inhaled or ingested in high concentrations. Therefore, it is important to handle hydrocarbons with care and follow proper safety protocols to prevent exposure.
In the medical field, creosote is a term that refers to a type of coal tar that is used as a medication to treat certain skin conditions. It is typically applied topically to the affected area in the form of a cream or ointment. Creosote is believed to work by reducing inflammation and slowing the growth of abnormal cells, which can help to improve the appearance of the skin and reduce symptoms such as itching and redness. It is most commonly used to treat conditions such as psoriasis, eczema, and dermatitis. However, it is important to note that creosote can be harmful if ingested or if it comes into contact with the eyes or mucous membranes, so it should be used with caution and under the guidance of a healthcare professional.
In the medical field, "Hydrocarbons, Aromatic" refers to a group of organic compounds that contain a ring of carbon atoms bonded to hydrogen atoms. These compounds are characterized by their strong odors and are often used as solvents, fuels, and industrial chemicals. Aromatic hydrocarbons are further classified into two main categories: polycyclic aromatic hydrocarbons (PAHs) and monoaromatic hydrocarbons. PAHs are compounds that contain two or more fused aromatic rings, while monoaromatic hydrocarbons contain only one aromatic ring. Exposure to aromatic hydrocarbons can have harmful effects on human health, including respiratory problems, skin irritation, and cancer. Some examples of aromatic hydrocarbons include benzene, toluene, and xylene, which are commonly found in gasoline, solvents, and other industrial products.
Carcinogens are substances or agents that have the potential to cause cancer. They can be found in various forms, including chemicals, radiation, and biological agents. Carcinogens can be classified into two categories: 1. Direct carcinogens: These are substances that can directly damage DNA and cause mutations, leading to the development of cancer. Examples of direct carcinogens include tobacco smoke, asbestos, and ultraviolet radiation. 2. Indirect carcinogens: These are substances that do not directly damage DNA but can cause cancer by promoting the growth and survival of cancer cells. Examples of indirect carcinogens include certain hormones, viruses, and certain chemicals found in food and water. Carcinogens can cause cancer by disrupting the normal functioning of cells, leading to uncontrolled growth and division. Exposure to carcinogens can occur through various means, including inhalation, ingestion, or skin contact. The risk of developing cancer from exposure to carcinogens depends on several factors, including the type and duration of exposure, the individual's age and overall health, and their genetic makeup.
Receptors, Aryl Hydrocarbon (AhR) are a type of protein receptors found in the cytoplasm of cells throughout the body. They are activated by a group of environmental pollutants called polycyclic aromatic hydrocarbons (PAHs), which are found in cigarette smoke, automobile exhaust, and other sources. Activation of AhR receptors can lead to a variety of biological responses, including changes in gene expression, immune system function, and metabolism. AhR receptors have been implicated in the development of a number of diseases, including cancer, cardiovascular disease, and respiratory disease.
DNA adducts are chemical modifications of DNA that occur when a foreign chemical molecule binds covalently to a DNA base. These modifications can be caused by exposure to environmental toxins, such as tobacco smoke or air pollution, as well as by certain medications or chemotherapy drugs. DNA adducts can lead to mutations in the DNA sequence, which can increase the risk of cancer and other diseases. In the medical field, DNA adducts are often studied as a way to assess a person's exposure to environmental toxins and to monitor the effectiveness of cancer treatments.
Benzopyrenes are a group of organic compounds that consist of a fused benzene ring and a pyrene ring. They are commonly found in the environment, including in tobacco smoke, automobile exhaust, and certain types of coal tar. In the medical field, benzopyrenes are of concern because they are known to be carcinogenic, meaning they can cause cancer. Exposure to benzopyrenes has been linked to an increased risk of lung cancer, skin cancer, and other types of cancer. They are also mutagenic, meaning they can cause changes in DNA that can lead to the development of cancer.
Coal tar is a dark, viscous liquid that is produced as a byproduct of the distillation of coal. It has been used in the medical field for centuries to treat a variety of skin conditions, including psoriasis, eczema, and seborrheic dermatitis. Coal tar works by reducing inflammation, slowing down the growth of skin cells, and killing bacteria and fungi that can cause skin infections. It is typically applied topically to the affected area, either as a cream, ointment, or shampoo. While coal tar can be effective in treating skin conditions, it can also cause side effects such as skin irritation, dryness, and discoloration. It is important to follow the instructions for use carefully and to consult a healthcare provider if you experience any adverse reactions.
Cytochrome P-450 CYP1A1 is an enzyme that plays a crucial role in the metabolism of various endogenous and exogenous compounds, including drugs, toxins, and hormones. It is a member of the cytochrome P450 family of enzymes, which are responsible for the oxidation of a wide range of substrates, including lipids, steroids, and xenobiotics. CYP1A1 is primarily expressed in the liver, lung, and extrahepatic tissues such as the gut, skin, and immune cells. It is induced by various environmental pollutants, such as polycyclic aromatic hydrocarbons (PAHs) and dioxins, as well as by certain drugs, such as the anticonvulsant phenobarbital. CYP1A1 is involved in the metabolism of many drugs, including the anti-cancer drug tamoxifen, the anti-inflammatory drug ibuprofen, and the anti-hypertensive drug propranolol. It also plays a role in the metabolism of environmental pollutants, such as PAHs and dioxins, which can cause a range of toxic effects, including cancer and reproductive disorders. In addition to its role in drug metabolism and environmental toxicology, CYP1A1 has been implicated in the metabolism of hormones, such as estrogen and testosterone, and in the regulation of immune responses. It is also involved in the metabolism of certain vitamins and minerals, such as vitamin D and iron. Overall, CYP1A1 is a critical enzyme in the metabolism of a wide range of compounds, and its activity can have significant effects on human health and disease.
In the medical field, "Coke" typically refers to Coca-Cola, a carbonated soft drink that contains caffeine, sugar, and other ingredients. While Coca-Cola is not typically used for medical purposes, it is sometimes used as a placebo in clinical trials or as a source of hydration in certain situations. However, excessive consumption of Coca-Cola or other sugary drinks has been linked to a number of health problems, including obesity, type 2 diabetes, and tooth decay.
Biodegradation, Environmental in the medical field refers to the process by which microorganisms break down and consume organic matter in the environment. This process is important in the management of medical waste, as it helps to reduce the amount of waste that is sent to landfills and reduces the risk of environmental contamination. Biodegradation can occur naturally, through the action of microorganisms in the environment, or it can be accelerated through the use of biodegradable materials or biodegradation agents. In the medical field, biodegradation is often used to dispose of medical waste, such as bandages, gauze, and other materials that are contaminated with bodily fluids or other potentially infectious materials.
Epoxy compounds are a type of polymer that are commonly used in the medical field for a variety of applications. They are formed by the reaction of an epoxy resin with a curing agent, which results in a strong, durable material with excellent adhesion properties. In the medical field, epoxy compounds are often used as adhesives to bond medical devices to the skin or other tissues. They are also used as coatings on medical equipment and implants to provide a barrier against infection and to improve the durability and longevity of the device. Epoxy compounds are also used in the production of medical implants, such as dental fillings and orthopedic implants. They are used to bond the implant to the surrounding bone or tissue, providing a strong and secure hold. Overall, epoxy compounds are an important tool in the medical field, providing a range of benefits including improved adhesion, durability, and infection control.
Acenaphthenes are a group of organic compounds that are composed of a benzene ring fused to a cyclohexane ring. They are commonly found in fossil fuels, such as coal and crude oil, and are also produced as byproducts of the refining process. In the medical field, acenaphthenes are not typically used as drugs or therapeutic agents. However, some studies have suggested that exposure to acenaphthenes may be associated with an increased risk of certain health problems, such as cancer and reproductive issues. For example, some studies have found that exposure to acenaphthenes may increase the risk of liver cancer in humans and laboratory animals. Acenaphthenes are also classified as environmental pollutants and are regulated by various environmental agencies. Exposure to acenaphthenes can occur through inhalation of contaminated air, ingestion of contaminated water or food, or skin contact with contaminated materials.
"Carcinogens, Environmental" refers to substances or agents in the environment that have the potential to cause cancer in humans or animals. These substances can be found in various forms, including air, water, soil, and food, and can be naturally occurring or man-made. Examples of environmental carcinogens include: 1. Radon gas 2. Polycyclic aromatic hydrocarbons (PAHs) 3. Asbestos 4. Benzene 5. Formaldehyde 6. Dioxins and furans 7. Mercury 8. Lead 9. Chromium 10. Nickel Exposure to environmental carcinogens can occur through various routes, including inhalation, ingestion, and skin contact. The risk of developing cancer from exposure to environmental carcinogens depends on several factors, including the duration and intensity of exposure, the individual's age, sex, and overall health, and the specific type of cancer being considered.
In the medical field, air pollutants refer to any substances that are present in the air and can have harmful effects on human health. These pollutants can be natural or man-made and can include gases, particles, and other substances that are released into the air through various sources such as industrial processes, transportation, and natural phenomena like wildfires. Some common air pollutants that are of concern in the medical field include: 1. Particulate matter (PM): These are tiny particles that are suspended in the air and can be inhaled into the lungs. PM can come from a variety of sources, including vehicle exhaust, industrial emissions, and wildfires. 2. Ozone (O3): Ozone is a gas that is formed when nitrogen oxides and volatile organic compounds react in the presence of sunlight. It can cause respiratory problems and exacerbate existing conditions like asthma and chronic obstructive pulmonary disease (COPD). 3. Sulfur dioxide (SO2): SO2 is a gas that is produced by burning fossil fuels and can cause respiratory problems, particularly in people with pre-existing conditions like asthma. 4. Nitrogen dioxide (NO2): NO2 is a gas that is produced by vehicle exhaust and can cause respiratory problems and contribute to the formation of ground-level ozone. 5. Carbon monoxide (CO): CO is a gas that is produced by incomplete combustion of fossil fuels and can interfere with the body's ability to use oxygen, leading to symptoms like headaches, dizziness, and nausea. 6. Volatile organic compounds (VOCs): VOCs are a group of chemicals that can evaporate easily and can cause respiratory problems and other health issues when inhaled. Overall, exposure to air pollutants can have a range of negative effects on human health, including respiratory problems, cardiovascular disease, and cancer. Therefore, it is important to monitor and control air pollution levels to protect public health.
Petroleum is not typically used in the medical field. It is a naturally occurring fossil fuel that is primarily used as a source of energy and raw material for various industrial processes, including the production of plastics, fertilizers, and lubricants. In the medical field, there are other substances that are used for various purposes, such as medications, medical devices, and imaging agents. These substances are typically derived from natural sources or synthesized in a laboratory setting and are carefully tested and regulated to ensure their safety and efficacy.
In the medical field, "Air Pollutants, Occupational" refers to harmful substances that are present in the air at workplaces and can cause adverse health effects on workers. These pollutants can be inhaled, absorbed through the skin, or ingested, and can include a wide range of chemicals, dusts, fumes, and gases. Examples of occupational air pollutants include asbestos, silica, lead, benzene, carbon monoxide, sulfur dioxide, nitrogen dioxide, and particulate matter. Exposure to these pollutants can cause a variety of respiratory and cardiovascular diseases, including asthma, chronic obstructive pulmonary disease (COPD), lung cancer, and heart disease. Occupational air pollution is a significant public health concern, as millions of workers worldwide are exposed to these pollutants on a daily basis. To protect workers' health, employers are required to comply with safety regulations and provide appropriate protective equipment and training.
In the medical field, "bays" typically refer to a section or area within a hospital or healthcare facility where patients are treated or cared for. For example, a hospital may have several bays in its emergency department where patients with urgent medical needs are triaged and treated. Each bay may have a bed, a nurse's station, and equipment such as a monitor and IV stand. In some cases, "bays" may also refer to specific areas within a patient's room, such as the "head bay" or "foot bay," which are designated areas for the patient's head or feet, respectively. Overall, the term "bays" is used in healthcare to describe a specific area or section within a facility where patients receive medical care.
Tetrachlorodibenzodioxin (TCDD) is a highly toxic and persistent organic pollutant that belongs to a class of compounds called polychlorinated dibenzo-p-dioxins (PCDDs). It is a colorless, odorless, and tasteless chemical that is primarily produced as a byproduct of industrial processes, such as the manufacture of pesticides, dyes, and bleaches. In the medical field, TCDD is known to cause a range of adverse health effects, including cancer, reproductive disorders, immune system dysfunction, and neurotoxicity. It is also a known teratogen, meaning that it can cause birth defects in developing fetuses if pregnant women are exposed to high levels of the chemical. TCDD is classified as a Class I carcinogen by the International Agency for Research on Cancer (IARC), which means that it is considered to be carcinogenic to humans based on sufficient evidence from studies in humans and animals. As a result, exposure to TCDD is strictly regulated by many countries, and efforts are being made to reduce its production and use to minimize human exposure.
Methylcholanthrene is a synthetic polycyclic aromatic hydrocarbon that is used as a laboratory chemical and as a carcinogen in research. It is classified as a mutagen and has been shown to cause cancer in animals and humans. In the medical field, methylcholanthrene is used as a model compound for studying the mechanisms of cancer development and for testing the efficacy of potential cancer treatments. It is also used in the development of new drugs and as a tool for studying the effects of environmental pollutants on human health.
I'm sorry, but I couldn't find any medical definition of "coal." Coal is a fossil fuel that is primarily used for energy production, but it is not typically used in the medical field. If you have any other questions, please let me know.
Fluorenes are a class of organic compounds that contain a benzene ring fused to a fluorine atom. They are typically colorless or yellowish solids with a characteristic odor. In the medical field, fluorenes have been studied for their potential use as drugs and as imaging agents. For example, some fluorenes have been shown to have anti-inflammatory and anti-cancer properties, while others have been used as fluorescent probes to visualize specific cellular processes. However, more research is needed to fully understand the potential therapeutic applications of fluorenes.
Biotransformation is a process in the body where foreign substances, such as drugs, toxins, and environmental chemicals, are converted into more water-soluble and easily excreted forms. This process occurs in the liver and involves various enzymes that modify the chemical structure of the substance, making it less toxic and more easily eliminated from the body. Biotransformation can occur through two main pathways: phase I and phase II. In phase I, enzymes called cytochrome P450 oxidize the substance, adding or removing hydrogen atoms, which can make the substance more reactive and potentially toxic. In phase II, enzymes such as glutathione S-transferases and UDP-glucuronosyltransferases add functional groups to the substance, making it more water-soluble and easier to excrete. Biotransformation is an important process in the body as it helps to detoxify harmful substances and prevent them from building up in the body. However, certain factors such as genetics, age, liver function, and certain medications can affect the rate and efficiency of biotransformation, which can impact the effectiveness and safety of drugs and other substances in the body.
In the medical field, "Vehicle Emissions" generally refers to the harmful gases and particles that are released into the air by vehicles, such as cars, trucks, buses, and motorcycles. These emissions can include carbon monoxide, nitrogen oxides, sulfur dioxide, particulate matter, and volatile organic compounds, among other pollutants. Exposure to vehicle emissions can have negative health effects on humans, particularly those with pre-existing respiratory or cardiovascular conditions. Long-term exposure to high levels of vehicle emissions can increase the risk of developing respiratory diseases such as asthma, bronchitis, and emphysema, as well as cardiovascular diseases such as heart attacks and strokes. In addition to the health effects on humans, vehicle emissions also contribute to air pollution, which can have negative impacts on the environment and climate. For example, air pollution can contribute to the formation of smog, which can reduce visibility and harm crops and other vegetation. It can also contribute to the formation of ground-level ozone, which can harm human health and damage crops and other vegetation.
Anthracenes are a group of organic compounds that are composed of a fused benzene ring system with two additional aromatic rings. They are typically found in coal tar and other fossil fuels, and are also produced as byproducts of the combustion of organic materials. In the medical field, anthracenes have been studied for their potential therapeutic effects. Some anthracenes have been found to have anti-inflammatory and anti-cancer properties, and are being investigated as potential treatments for a variety of diseases, including cancer, inflammatory bowel disease, and psoriasis. However, more research is needed to fully understand the potential benefits and risks of using anthracenes as a treatment.
Dihydroxydihydrobenzopyrenes (DHDHPs) are a group of organic compounds that are formed as metabolites of polycyclic aromatic hydrocarbons (PAHs) in the human body. PAHs are a group of chemicals that are found in a variety of environmental sources, including tobacco smoke, car exhaust, and certain types of fuel. DHDHPs are formed when PAHs are metabolized by the liver, and they are thought to be involved in the development of certain types of cancer, including lung cancer and bladder cancer. They are also thought to be involved in the development of other health problems, such as cardiovascular disease and respiratory problems. In the medical field, DHDHPs are often measured in biological samples, such as blood or urine, as a way to assess a person's exposure to PAHs and to monitor their health. They are also studied in laboratory experiments to better understand their potential health effects.
High-pressure liquid chromatography (HPLC) is a technique used in the medical field to separate and analyze complex mixtures of compounds. It involves the use of a liquid mobile phase that is forced through a column packed with a stationary phase under high pressure. The compounds in the mixture interact with the stationary phase to different extents, causing them to separate as they pass through the column. The separated compounds are then detected and quantified using a detector, such as a UV detector or a mass spectrometer. HPLC is commonly used in the analysis of drugs, biological samples, and other complex mixtures in the medical field.
Aryl Hydrocarbon Hydroxylases (AHHs) are a group of enzymes that are involved in the metabolism of aromatic hydrocarbons, such as polycyclic aromatic hydrocarbons (PAHs) and halogenated aromatic hydrocarbons (HAHs). These enzymes are primarily found in the liver and are responsible for the oxidation of these compounds to their corresponding hydroxylated derivatives. AHHs play an important role in the detoxification of these compounds, as the hydroxylated derivatives are more water-soluble and can be more easily excreted from the body. In addition, the hydroxylation of aromatic hydrocarbons can also lead to the formation of reactive intermediates, such as quinones, which can be further metabolized or detoxified by other enzymes. AHHs are also involved in the metabolism of other compounds, such as certain drugs and hormones. Mutations in the genes encoding AHHs can lead to impaired metabolism of these compounds, which can result in toxicity or other health effects. In the medical field, AHHs are often studied in the context of their role in the metabolism of environmental pollutants and their potential health effects. For example, exposure to PAHs and HAHs has been linked to an increased risk of cancer and other health problems, and AHHs are thought to play a key role in this process.
In the medical field, "Hydrocarbons, Halogenated" refers to a group of organic compounds that contain both hydrogen and carbon atoms, with one or more halogen atoms (fluorine, chlorine, bromine, or iodine) replacing one or more hydrogen atoms. These compounds are often used as solvents, propellants, and refrigerants, and some are also used as medical gases for anesthesia and respiratory support. Some examples of halogenated hydrocarbons include chloroform, trichloroethylene, and tetrachloroethylene, which have been used in various medical applications such as as anesthetic agents, sterilizing agents, and solvents for medical equipment. However, many of these compounds have been found to be toxic and carcinogenic, and their use has been restricted or banned in many countries.
In the medical field, particulate matter (PM) refers to tiny solid or liquid particles that are suspended in the air. These particles can be inhaled into the lungs and can cause a range of health problems, including respiratory and cardiovascular diseases. PM can be classified based on their size, with smaller particles being more harmful to health. PM2.5 refers to particles with a diameter of 2.5 micrometers or less, while PM10 refers to particles with a diameter of 10 micrometers or less. These particles can penetrate deep into the lungs and even enter the bloodstream, causing inflammation and oxidative stress. Exposure to high levels of PM can increase the risk of developing conditions such as asthma, chronic obstructive pulmonary disease (COPD), lung cancer, and heart disease. It can also exacerbate existing health conditions and increase the risk of premature death. In summary, particulate matter is a type of air pollution that can have serious health consequences when inhaled. It is an important consideration in public health and environmental policy, and efforts are being made to reduce its levels in the air.
In the medical field, "fuel oils" typically refers to a type of petroleum-based fuel that is used to generate heat or power in industrial or commercial settings. These fuels are typically used in boilers, furnaces, and other heating systems, as well as in power plants and other large-scale energy generation facilities. Fuel oils can be divided into several different categories based on their properties and intended use. For example, there are distillate fuels, such as diesel and heating oil, which are lighter and more volatile than heavier fuel oils like bunker fuel and residual fuel oil. These different types of fuel oils have different combustion characteristics and may be used in different types of equipment or applications. In some cases, exposure to fuel oils can be a health hazard for workers in industrial or commercial settings. For example, workers who handle or transport fuel oils may be at risk of skin irritation, respiratory problems, or other health issues related to exposure to the chemicals in these fuels. In addition, fuel oils can be a source of air pollution if they are not burned efficiently or if they are released into the environment through leaks or spills.
In the medical field, "cooking" typically refers to the process of preparing food for consumption by humans. This can include tasks such as chopping vegetables, boiling water, and baking bread. Cooking is an important aspect of maintaining a healthy diet, as it can help to preserve the nutritional value of food and make it more palatable. In some cases, cooking may also be used as a therapeutic intervention for patients with certain medical conditions, such as those with swallowing difficulties or digestive problems.
Naphthalenes are a group of organic compounds that are composed of two benzene rings fused together. They are commonly used as insecticides and moth repellents, and have also been used in the past as a treatment for certain medical conditions such as respiratory infections and skin infections. However, the use of naphthalenes as a medical treatment is now generally discouraged due to their potential toxicity and the availability of safer alternatives. In the medical field, naphthalenes are primarily used as a research tool to study the effects of benzene ring compounds on various biological processes.
Dioxins are a group of toxic chemicals that are formed as byproducts of various industrial processes, such as the manufacture of pesticides, bleaching agents, and other chemicals. They are also found in the environment as a result of natural processes, such as forest fires and volcanic eruptions. In the medical field, dioxins are known to have a wide range of harmful effects on human health. Exposure to dioxins can cause a variety of symptoms, including skin rashes, respiratory problems, and damage to the liver, kidneys, and immune system. Long-term exposure to dioxins has also been linked to an increased risk of cancer, particularly of the liver, lungs, and breast. Dioxins are highly toxic and can accumulate in the body over time, leading to long-term health effects. As a result, exposure to dioxins is closely monitored by regulatory agencies, and efforts are made to reduce their production and use in industrial processes.
9,10-Dimethyl-1,2-benzanthracene is a chemical compound that is not commonly used in the medical field. It is a polycyclic aromatic hydrocarbon (PAH) that is structurally similar to benzanthracene, a naturally occurring PAH found in coal tar and other fossil fuels. There is limited information available on the potential medical uses or effects of 9,10-Dimethyl-1,2-benzanthracene. However, some studies have suggested that PAHs, including benzanthracene and related compounds, may have carcinogenic effects and may be associated with an increased risk of certain types of cancer, such as lung cancer and bladder cancer. It is important to note that 9,10-Dimethyl-1,2-benzanthracene is not a standard medical treatment or diagnostic tool, and its use should be carefully considered and monitored by a qualified healthcare professional.
Benzoflavones are a class of organic compounds that are derived from the combination of a benzene ring and a flavone structure. They are a subclass of flavonoids, which are a large group of natural compounds found in plants that have a variety of biological activities, including antioxidant, anti-inflammatory, and anticancer properties. Benzoflavones are primarily found in certain fruits, vegetables, and herbs, such as citrus fruits, onions, and parsley. They have been studied for their potential health benefits, including their ability to protect against cancer, reduce inflammation, and improve cardiovascular health. In the medical field, benzoflavones have been investigated for their potential use in the treatment of various conditions, including cancer, cardiovascular disease, and inflammatory disorders. Some studies have suggested that benzoflavones may have anti-cancer properties, particularly in the prevention of breast and prostate cancer. They may also have a protective effect against cardiovascular disease by reducing inflammation and improving blood flow. However, more research is needed to fully understand the potential health benefits of benzoflavones and to determine the optimal dosage and duration of treatment. Additionally, some studies have suggested that benzoflavones may interact with certain medications, so it is important to consult with a healthcare provider before taking them.
In the medical field, "Amino Acids, Aromatic" refers to a group of amino acids that contain an aromatic ring in their side chain. These amino acids are important building blocks of proteins and play various roles in the body, including as neurotransmitters, hormones, and enzymes. The nine amino acids that are classified as aromatic are phenylalanine, tyrosine, tryptophan, histidine, methionine, and cysteine. These amino acids are essential for human health and must be obtained through the diet, as the body cannot produce them on its own. A deficiency in any of these amino acids can lead to various health problems, such as intellectual disabilities, skin disorders, and metabolic disorders. Therefore, it is important to ensure that the diet includes adequate amounts of these amino acids.
Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) is a protein that plays a crucial role in the regulation of gene expression in response to environmental toxins and other stressors. It is a member of the basic helix-loop-helix/Per-Arnt-Sim (bHLH/PAS) family of transcription factors, which are involved in a wide range of cellular processes, including development, metabolism, and stress response. ARNT is primarily known for its role in the aryl hydrocarbon receptor (AhR) pathway, which is activated by a variety of environmental pollutants, such as polycyclic aromatic hydrocarbons (PAHs) and dioxins. When AhR binds to these pollutants, it forms a heterodimer with ARNT, which then translocates to the nucleus and binds to specific DNA sequences called xenobiotic response elements (XREs). This binding leads to the recruitment of other transcription factors and coactivators, which ultimately result in the activation of target genes involved in detoxification, metabolism, and immune response. ARNT is also involved in other signaling pathways, such as the hypoxia-inducible factor (HIF) pathway, which plays a critical role in the regulation of oxygen homeostasis in cells. In this pathway, ARNT forms a heterodimer with HIF-1α, which then translocates to the nucleus and binds to specific DNA sequences called hypoxia response elements (HREs). This binding leads to the activation of target genes involved in angiogenesis, erythropoiesis, and glucose metabolism. Overall, ARNT is a key regulator of cellular responses to environmental stressors and plays a critical role in maintaining cellular homeostasis.
Naphthols are a class of organic compounds that contain a naphthalene ring with a hydroxyl group (-OH) attached to it. They are commonly used in the medical field as dyes, stains, and disinfectants. Some naphthols are also used as pharmaceuticals, such as naphthol AS-D chloroacetate, which is used as a topical antiseptic and disinfectant. Other naphthols, such as 2-naphthol, have been studied for their potential anti-inflammatory and analgesic effects. However, some naphthols, such as 1-naphthol, are considered hazardous and can cause skin irritation, respiratory problems, and other health issues if they are inhaled or ingested.
Beta-naphthoflavone is a chemical compound that belongs to the class of flavonoids. It is a yellowish-brown solid that is insoluble in water but soluble in organic solvents such as ethanol and acetone. In the medical field, beta-naphthoflavone has been studied for its potential anti-cancer properties. It has been shown to induce the production of enzymes that help to detoxify carcinogens and to inhibit the growth of cancer cells in vitro and in animal models. However, it is important to note that beta-naphthoflavone is not currently used as a therapeutic agent in humans, and more research is needed to fully understand its potential benefits and risks. Additionally, beta-naphthoflavone is a known mutagen and carcinogen, and exposure to high levels of this compound can be harmful to human health.
In the medical field, "steel" typically refers to surgical instruments made of stainless steel. Stainless steel is a type of steel that contains a minimum of 10.5% chromium, which makes it resistant to corrosion and rust. Surgical instruments made of stainless steel are commonly used in a variety of medical procedures, including surgeries, wound care, and dental procedures. These instruments are designed to be durable, precise, and easy to clean and sterilize. It's worth noting that while stainless steel is a common material used in surgical instruments, there are other materials that may be used as well, such as titanium, carbon fiber, and ceramic. The choice of material depends on the specific application and the desired properties of the instrument.
In the medical field, "Hydrocarbons, Chlorinated" refers to a group of organic compounds that contain carbon and hydrogen atoms, with one or more chlorine atoms replacing some of the hydrogen atoms. These compounds are commonly used as solvents, degreasers, and in the production of various chemicals and plastics. Some chlorinated hydrocarbons, such as trichloroethylene (TCE) and perchloroethylene (PCE), have been linked to various health problems, including liver and kidney damage, cancer, and reproductive issues. Exposure to these compounds can occur through inhalation, ingestion, or skin contact, and can occur in the workplace or through contaminated water and soil. In recent years, there has been growing concern about the potential health effects of chlorinated hydrocarbons, and efforts have been made to reduce their use and exposure.
Dioxygenases are a class of enzymes that catalyze the addition of molecular oxygen (O2) to a substrate molecule. These enzymes are involved in a wide range of biological processes, including the metabolism of lipids, carbohydrates, and amino acids, as well as the detoxification of harmful substances. Dioxygenases can be classified into several different types based on the specific chemical reaction they catalyze and the type of substrate they act on. For example, cytochrome P450 enzymes are a type of dioxygenase that are involved in the metabolism of drugs and other xenobiotics, while lipoxygenases are involved in the metabolism of fatty acids. Dioxygenases play an important role in maintaining the health of living organisms, but they can also contribute to the development of disease. For example, certain mutations in dioxygenase genes can lead to the production of abnormal enzymes that are unable to function properly, which can result in a variety of health problems. Additionally, some dioxygenases can produce reactive oxygen species (ROS) as a byproduct of their activity, which can cause damage to cellular components and contribute to the development of diseases such as cancer and aging.
In the medical field, "Air Pollution, Indoor" refers to the presence of harmful substances in the air within a building or enclosed space, such as homes, offices, schools, and hospitals. These substances can include particulate matter, volatile organic compounds (VOCs), carbon monoxide (CO), nitrogen dioxide (NO2), sulfur dioxide (SO2), and other pollutants. Indoor air pollution can have a significant impact on human health, particularly for people who spend a lot of time indoors, such as children, the elderly, and people with pre-existing respiratory or cardiovascular conditions. Exposure to indoor air pollution can cause a range of health problems, including respiratory infections, asthma, allergies, headaches, dizziness, and even cancer. To reduce indoor air pollution, it is important to identify and address the sources of pollution, such as smoking, cooking, cleaning products, and building materials. This can involve using natural ventilation, improving indoor air quality through the use of air purifiers, and implementing building codes and regulations to reduce emissions from building materials and appliances.
The cytochrome P-450 enzyme system is a group of enzymes that are responsible for the metabolism of a wide variety of drugs, toxins, and other substances in the body. These enzymes are found in the liver, lungs, and other organs, and they play a critical role in the detoxification of harmful substances and the elimination of drugs from the body. The cytochrome P-450 enzymes are classified into several families, each of which is responsible for the metabolism of specific types of compounds. For example, the CYP3A family is responsible for the metabolism of a wide variety of drugs, including many commonly prescribed medications. The CYP2D6 family is responsible for the metabolism of some antidepressants, antipsychotics, and other drugs. The activity of the cytochrome P-450 enzyme system can be affected by a variety of factors, including genetic variations, age, sex, and the presence of other medications. In some cases, these factors can lead to differences in the metabolism of drugs, which can affect their effectiveness and the risk of side effects. Overall, the cytochrome P-450 enzyme system plays a critical role in the metabolism of drugs and other substances in the body, and understanding its function is important for the safe and effective use of medications.
Polychlorinated biphenyls (PCBs) are a group of synthetic organic compounds that were widely used in various industrial applications, including electrical equipment, insulation materials, and hydraulic fluids, until they were banned in many countries due to their toxicity and persistence in the environment. In the medical field, PCBs are known to have a range of adverse health effects, including cancer, reproductive disorders, and neurodevelopmental problems. Exposure to PCBs can occur through ingestion, inhalation, or skin contact, and can occur occupationally or through environmental exposure. PCBs are classified as persistent organic pollutants (POPs) because they are resistant to degradation and can accumulate in the environment and in the bodies of living organisms. As a result, they can have long-term health effects, even at low levels of exposure.
Glutathione transferase (GST) is an enzyme that plays a crucial role in the detoxification of various harmful substances in the body, including drugs, toxins, and carcinogens. It is a member of a large family of enzymes that are found in all living organisms and are involved in a wide range of biological processes, including metabolism, cell signaling, and immune response. In the medical field, GST is often studied in relation to various diseases and conditions, including cancer, liver disease, and neurodegenerative disorders. GST enzymes are also used as biomarkers for exposure to environmental toxins and as targets for the development of new drugs for the treatment of these conditions. Overall, GST is an important enzyme that helps to protect the body from harmful substances and plays a critical role in maintaining overall health and well-being.
In the medical field, gasoline is not typically used as a medical treatment or diagnostic tool. Gasoline is a flammable liquid that is primarily used as a fuel for internal combustion engines, such as those found in cars, trucks, and other vehicles. However, gasoline can be a dangerous substance if it is ingested or inhaled in large quantities. Ingesting gasoline can cause nausea, vomiting, abdominal pain, and even death. Inhaling gasoline fumes can cause dizziness, headaches, and respiratory problems, and can also be fatal if exposure is prolonged or severe. If someone has ingested or inhaled gasoline, it is important to seek medical attention immediately. Treatment may involve removing the gasoline from the body, providing supportive care to manage symptoms, and addressing any long-term health effects.
In the medical field, "smoke" typically refers to the inhalation of particles and gases that are produced by the burning of organic materials, such as tobacco, wood, or fossil fuels. When inhaled, these particles and gases can cause a range of health problems, including respiratory issues, heart disease, and cancer. In some cases, smoke can also refer to the use of smoke as a therapeutic tool, such as in the practice of acupuncture, where a small amount of smoke is produced by burning herbs or other substances to stimulate specific points on the body. Overall, the medical use of the term "smoke" is typically related to the harmful effects of inhaling smoke from burning materials, rather than the therapeutic use of smoke as a tool for healing.
In the medical field, hazardous waste refers to any waste material that poses a significant risk to human health or the environment if not properly managed. This includes a wide range of materials, such as used needles, syringes, chemotherapy drugs, biological waste, and pharmaceuticals. Hazardous medical waste must be handled and disposed of according to strict regulations to prevent the spread of infectious diseases and to protect the environment. These regulations are typically enforced by local, state, and federal agencies, and may vary depending on the type and amount of waste being generated. Proper management of hazardous medical waste includes segregation, labeling, packaging, transportation, treatment, and disposal. Segregation involves separating waste into different categories based on its hazard level, while labeling and packaging ensure that waste is clearly identified and protected during transportation. Treatment may involve incineration, chemical neutralization, or other methods to reduce the risk of exposure to hazardous materials. Finally, disposal involves safely disposing of waste in a manner that minimizes its impact on the environment and human health.
I'm sorry, but I cannot find any medical definition for "Coal Ash." Coal ash is a waste product generated during the combustion of coal, and it is typically not used in the medical field. However, coal ash can contain harmful substances such as heavy metals and radioactive materials, and exposure to it can have negative health effects. If you have any concerns about your exposure to coal ash or its potential health effects, I would recommend consulting with a healthcare professional.
In the medical field, alkanes are a group of organic compounds that consist of only carbon and hydrogen atoms. They are the simplest type of hydrocarbon and are often used as solvents, lubricants, and in the production of various medical products. Alkanes are typically classified based on the number of carbon atoms they contain, with the simplest alkane being methane (CH4) and the most complex being undecane (C11H24). Some common alkanes used in medicine include ethane (C2H6), propane (C3H8), butane (C4H10), and pentane (C5H12). Alkanes can be used in a variety of medical applications, including as solvents for medications, as components in medical devices, and as precursors for the production of other medical compounds. However, it is important to note that some alkanes can also be toxic and may cause adverse effects when inhaled or ingested in large quantities.
In the medical field, the term "astronomy" is not commonly used. However, there is a medical condition called "astronomical vertigo" which is a type of vertigo that is characterized by severe dizziness and a feeling of spinning that is worse when the head is moved. This condition is caused by a problem with the inner ear, specifically the vestibular system, which is responsible for maintaining balance and spatial orientation. Treatment for astronomical vertigo typically involves medications to reduce dizziness and physical therapy to help the brain and inner ear adapt to the changes in balance.
Benzene is a colorless, sweet-smelling liquid that is commonly used as a solvent in various industries, including the production of plastics, rubber, dyes, and detergents. In the medical field, benzene is not typically used as a treatment or medication, but it can be a hazardous substance that can cause health problems if exposure occurs. Long-term exposure to benzene can lead to a range of health problems, including leukemia, a type of cancer that affects the blood and bone marrow. Benzene can also cause damage to the liver, kidneys, and central nervous system, and it can affect the immune system and cause anemia. In the workplace, benzene exposure is regulated by the Occupational Safety and Health Administration (OSHA), which sets limits on the amount of benzene that workers can be exposed to over a certain period of time. Workers who are exposed to benzene may be required to wear protective clothing and equipment, and they may need to take breaks or use respiratory protection to reduce their exposure. In addition to workplace exposure, benzene can also be found in the environment, including in air, water, and soil. People who live in areas with high levels of benzene exposure may be at increased risk of health problems, including cancer and other types of illness.
Cytochrome P-450 CYP1A2 is an enzyme that plays a crucial role in the metabolism of various drugs and toxins in the human body. It is a member of the cytochrome P450 family of enzymes, which are responsible for the oxidation of a wide range of substrates, including drugs, hormones, and environmental pollutants. CYP1A2 is primarily expressed in the liver, but it is also found in other tissues such as the lungs, kidneys, and gastrointestinal tract. It is involved in the metabolism of many commonly used drugs, including caffeine, theophylline, and certain antidepressants, as well as some environmental pollutants, such as polycyclic aromatic hydrocarbons (PAHs) and dioxins. The activity of CYP1A2 can be influenced by a variety of factors, including genetic polymorphisms, age, sex, and exposure to certain chemicals. Variations in CYP1A2 activity can affect the metabolism and clearance of drugs, leading to differences in drug response and toxicity among individuals. Therefore, understanding the role of CYP1A2 in drug metabolism is important for optimizing drug therapy and minimizing adverse effects.
Epoxide hydrolases are a group of enzymes that catalyze the hydrolysis of epoxides, which are three-membered cyclic ethers. These enzymes play an important role in the metabolism of various compounds, including some drugs and environmental pollutants. In the medical field, epoxide hydrolases are of particular interest because they can modulate the activity of certain drugs by converting them into less active or inactive metabolites. For example, some anti-cancer drugs, such as tamoxifen and etoposide, are activated by epoxide hydrolases in certain tissues, while others, such as benzo[a]pyrene, are detoxified by these enzymes. Epoxide hydrolases are also involved in the metabolism of some endogenous compounds, such as fatty acids and bile acids. In addition, they have been implicated in the development of certain diseases, including cancer, cardiovascular disease, and neurodegenerative disorders. Overall, epoxide hydrolases play a critical role in the metabolism of a wide range of compounds, and their activity can have important implications for human health.
In the medical field, the term "construction materials" typically refers to the various materials and substances used in the construction and maintenance of medical facilities, such as hospitals, clinics, and laboratories. These materials can include a wide range of substances, such as metals, plastics, ceramics, and composites, as well as specialized materials designed for specific medical applications, such as antimicrobial coatings or materials that can be sterilized easily. The selection and use of construction materials in the medical field is critical to ensuring the safety and health of patients, medical staff, and visitors. Medical facilities must comply with strict regulations and guidelines regarding the use of construction materials, including requirements for durability, safety, and infection control. Additionally, medical facilities must consider the environmental impact of their construction materials, including the potential for toxicity and waste generation.
In the medical field, dust refers to a mixture of small particles that are suspended in the air. These particles can come from a variety of sources, including soil, pollen, pet dander, and human skin cells. Dust can be inhaled and can cause a range of health problems, including respiratory issues such as asthma, bronchitis, and pneumonia. It can also cause irritation of the eyes, nose, and throat, and can exacerbate existing conditions such as allergies and eczema. In some cases, exposure to certain types of dust can be hazardous, such as asbestos or silica dust, which can cause serious health problems if inhaled in large quantities.
Biological markers, also known as biomarkers, are measurable indicators of biological processes, pathogenic processes, or responses to therapeutic interventions. In the medical field, biological markers are used to diagnose, monitor, and predict the progression of diseases, as well as to evaluate the effectiveness of treatments. Biological markers can be found in various biological samples, such as blood, urine, tissue, or body fluids. They can be proteins, genes, enzymes, hormones, metabolites, or other molecules that are associated with a specific disease or condition. For example, in cancer, biological markers such as tumor markers can be used to detect the presence of cancer cells or to monitor the response to treatment. In cardiovascular disease, biological markers such as cholesterol levels or blood pressure can be used to assess the risk of heart attack or stroke. Overall, biological markers play a crucial role in medical research and clinical practice, as they provide valuable information about the underlying biology of diseases and help to guide diagnosis, treatment, and monitoring.
In the medical field, oxygenases are enzymes that catalyze the addition of oxygen to a substrate molecule. These enzymes are involved in a wide range of biological processes, including the metabolism of drugs, the synthesis of hormones and other signaling molecules, and the detoxification of harmful substances. There are many different types of oxygenases, each with its own specific substrate and reaction mechanism. Some examples of oxygenases include cytochrome P450 enzymes, which are involved in the metabolism of drugs and other xenobiotics, and peroxidases, which are involved in the detoxification of reactive oxygen species. Oxygenases play a critical role in maintaining the health of living organisms, and their dysfunction can lead to a variety of diseases and disorders. For example, mutations in certain cytochrome P450 enzymes can lead to drug metabolism disorders, while deficiencies in peroxidases can contribute to the development of oxidative stress-related diseases.
In the medical field, complex mixtures refer to a type of substance that is composed of multiple components or ingredients, often with varying chemical structures and properties. These mixtures can be found in a variety of contexts, including pharmaceuticals, food and beverages, environmental pollutants, and consumer products. Complex mixtures can be challenging to study and understand because their individual components interact with each other in complex ways, and their overall effects on health and the environment may not be predictable based on the properties of the individual components alone. As a result, researchers and regulators often rely on a variety of analytical techniques and modeling approaches to study complex mixtures and assess their potential risks. Some examples of complex mixtures in the medical field include tobacco smoke, diesel exhaust, and certain types of air pollution. These mixtures contain a variety of chemicals, including carcinogens, irritants, and toxicants, that can have a range of adverse effects on human health, including respiratory problems, cardiovascular disease, and cancer.
In the medical field, nitro compounds refer to a class of organic compounds that contain the nitro group (-NO2) as a functional group. These compounds are known for their ability to release nitric oxide (NO) when they are metabolized or decomposed. Nitric oxide is a gas that plays a crucial role in various physiological processes in the body, including vasodilation (widening of blood vessels), neurotransmission, and immune function. Nitro compounds can be used as medications to enhance the production of nitric oxide and improve blood flow to the heart and brain, which can be beneficial in the treatment of conditions such as angina, heart attack, and stroke. However, some nitro compounds can also be toxic and can cause adverse effects when ingested or inhaled. For example, some explosives and military-grade munitions contain nitro compounds, and exposure to these compounds can cause respiratory distress, burns, and other injuries. Therefore, proper handling and storage of nitro compounds are essential to prevent accidental exposure and ensure their safe use in medical applications.
In the medical field, organic chemicals refer to compounds that are composed of carbon and hydrogen atoms, and may also contain other elements such as oxygen, nitrogen, sulfur, and halogens. These compounds are often used in the development of drugs, medical devices, and other medical products. Organic chemicals can be further classified into various categories based on their chemical structure and properties. For example, some organic chemicals are used as antioxidants, while others are used as anti-inflammatory agents, analgesics, or antibiotics. Some organic chemicals are also used as solvents, plasticizers, or dyes. In the medical field, organic chemicals are often synthesized in the laboratory and tested for their efficacy and safety before being used in medical products. They may also be extracted from natural sources, such as plants or animals, and used in their natural form or modified to enhance their therapeutic properties. It is important to note that not all organic chemicals are safe or effective for medical use, and some may even be toxic or carcinogenic. Therefore, the use of organic chemicals in the medical field is closely regulated by government agencies and requires careful evaluation and testing to ensure their safety and efficacy.
Deoxyguanosine is a nucleoside, which is a building block of DNA and RNA. It is composed of a deoxyribose sugar molecule, a nitrogenous base (guanine), and a phosphate group. In DNA, deoxyguanosine is paired with cytosine through hydrogen bonding, forming the base pair G-C. Deoxyguanosine is an important component of DNA and plays a crucial role in the storage and transmission of genetic information. In the medical field, deoxyguanosine is used as a component of antiviral drugs, such as zidovudine (AZT), which are used to treat HIV infection. It is also used in the treatment of certain types of cancer, such as acute myeloid leukemia and Hodgkin's lymphoma.
In the medical field, the term "cities" typically refers to urban areas or densely populated regions that have a high concentration of people, buildings, and infrastructure. These areas can be characterized by a variety of factors, including high levels of pollution, traffic congestion, and social and economic inequality. In the context of public health, cities are often studied as they can have a significant impact on the health and well-being of their residents. For example, researchers may investigate the relationship between urbanization and the incidence of certain diseases, such as heart disease or respiratory illness, or they may study the impact of urban planning and design on physical activity levels and access to healthy food options. Overall, the term "cities" in the medical field is used to describe the complex and dynamic environments in which many people live and work, and to highlight the importance of considering the social, economic, and environmental factors that can influence health outcomes in urban areas.
7-Alkoxycoumarin O-dealkylase is an enzyme that is involved in the metabolism of certain drugs and chemicals in the body. It is responsible for breaking down a specific type of molecule called 7-alkoxycoumarins, which are found in some medications and natural compounds. The enzyme catalyzes the removal of an alkyl group (a carbon-based molecule) from the 7-position of the coumarin molecule, resulting in the formation of a new compound. This process is an important step in the elimination of these substances from the body, and any disruption in the activity of the enzyme can affect the metabolism and elimination of the drug or chemical.
In the medical field, the term "fossil fuels" is not commonly used. However, it is worth noting that the burning of fossil fuels, such as coal, oil, and natural gas, is a major source of air pollution, which can have negative health effects on humans. Exposure to air pollution has been linked to a variety of health problems, including respiratory diseases, heart disease, and cancer. Therefore, reducing the use of fossil fuels and transitioning to cleaner sources of energy is an important public health concern.
Azacosterol is a synthetic analog of cholesterol that has been used in the treatment of various medical conditions. It is a type of corticosteroid, which is a class of drugs that are derived from hormones produced by the adrenal gland. Corticosteroids are used to treat a wide range of conditions, including inflammation, autoimmune disorders, and allergies. Azacosterol is typically used to treat skin conditions such as eczema, psoriasis, and dermatitis. It works by reducing inflammation and suppressing the immune system, which can help to reduce symptoms such as itching, redness, and swelling. Azacosterol is available in various forms, including creams, ointments, and gels, and is usually applied to the affected area of the skin once or twice a day. It is important to note that azacosterol can have side effects, including thinning of the skin, increased sensitivity to sunlight, and changes in skin color. It is also important to follow the instructions for use carefully and to speak with a healthcare provider if you have any questions or concerns about using this medication.
In the medical field, "soil" typically refers to the microorganisms and other biological material that can be found in soil. These microorganisms can include bacteria, viruses, fungi, and parasites, and can be present in various forms, such as in soil particles or as free-living organisms. Soil can also refer to the physical and chemical properties of the soil, such as its texture, pH, nutrient content, and water-holding capacity. These properties can affect the growth and health of plants, and can also impact the spread of soil-borne diseases and infections. In some cases, soil can also be used as a medium for growing plants in a controlled environment, such as in a greenhouse or laboratory setting. In these cases, the soil may be specially formulated to provide the necessary nutrients and conditions for optimal plant growth.
In the medical field, aluminum is a metal that is commonly used in various medical devices and implants. It is often used in orthopedic implants, such as hip and knee replacements, due to its strength, durability, and biocompatibility. However, aluminum has also been linked to certain health problems, particularly in individuals with kidney disease or other conditions that affect the body's ability to excrete aluminum. Long-term exposure to high levels of aluminum has been associated with an increased risk of Alzheimer's disease, Parkinson's disease, and other neurological disorders. Therefore, in the medical field, the use of aluminum in medical devices and implants is carefully regulated to minimize the risk of aluminum exposure and potential health effects.
In the medical field, glucuronates refer to a group of compounds that are formed by the conjugation of a glucuronic acid molecule with another molecule, such as a drug, a hormone, or a xenobiotic substance. This process, known as glucuronidation, is an important mechanism for the elimination of many substances from the body, including drugs, toxins, and metabolic waste products. Glucuronates are typically excreted in the urine and bile, and they can be measured in biological samples to assess the metabolism and elimination of drugs and other substances. In addition, some glucuronates have been shown to have biological activity, such as anti-inflammatory and anti-cancer effects, and they are being studied as potential therapeutic agents.
Nitrosamines are a group of organic compounds that are formed by the reaction of amines with nitric oxide or nitrous acid. They are commonly found in a variety of industrial and environmental settings, as well as in certain foods and tobacco products. In the medical field, nitrosamines are of concern because they are potent carcinogens, meaning that they can cause cancer in animals and humans. Exposure to nitrosamines has been linked to an increased risk of several types of cancer, including stomach cancer, liver cancer, and colorectal cancer. Because of their carcinogenic properties, nitrosamines are regulated by various government agencies around the world, and efforts are being made to reduce exposure to these compounds in food and other products.
In the medical field, the term "astronomical phenomena" is not commonly used. It is more commonly used in the field of astronomy to refer to natural events that occur in space, such as eclipses, comets, and supernovae. However, if we were to interpret the term "astronomical phenomena" in a broader sense to include any unusual or rare events that occur in the natural world, it could potentially be applied to certain medical conditions or events. For example, a rare genetic disorder or a medical condition that affects a small number of people could be considered an "astronomical phenomenon" in the medical field. It's important to note that this interpretation of the term is not commonly used in the medical field, and it is more common to use specific medical terminology to describe conditions and events.
Quinones are a class of organic compounds that contain a fused aromatic ring system with a keto group. They are commonly found in plants and microorganisms and have a variety of biological activities, including antioxidant, anti-inflammatory, and anticancer properties. In the medical field, quinones are used as active ingredients in a number of drugs, including antibiotics, antimalarials, and anticancer agents. For example, quinolones are a class of antibiotics that are derived from quinones and are used to treat a variety of bacterial infections. Quinine, a quinone derivative, is used to treat malaria. Additionally, some quinones are being studied as potential treatments for cancer, as they have been shown to have anti-tumor activity in preclinical studies.
Basidiomycota is a phylum of fungi that includes mushrooms, toadstools, and other types of fungi that produce a distinctive reproductive structure called a basidium. These fungi are important decomposers in many ecosystems and are also used in the production of food, medicine, and other products. In the medical field, Basidiomycota are of interest because some species can cause infections in humans and animals. These infections, known as mycoses, can range from superficial skin infections to more serious systemic infections that can be life-threatening. Some common examples of Basidiomycota that can cause infections include Cryptococcus neoformans, which can cause meningitis and other central nervous system infections, and Histoplasma capsulatum, which can cause histoplasmosis, a respiratory infection. In addition to causing infections, some species of Basidiomycota have potential medical applications. For example, certain species of mushrooms have been found to have anti-cancer properties, and some species of yeast in the Basidiomycota phylum are used in the production of bread, beer, and other fermented foods.
DNA, or deoxyribonucleic acid, is a molecule that carries genetic information in living organisms. It is composed of four types of nitrogen-containing molecules called nucleotides, which are arranged in a specific sequence to form the genetic code. In the medical field, DNA is often studied as a tool for understanding and diagnosing genetic disorders. Genetic disorders are caused by changes in the DNA sequence that can affect the function of genes, leading to a variety of health problems. By analyzing DNA, doctors and researchers can identify specific genetic mutations that may be responsible for a particular disorder, and develop targeted treatments or therapies to address the underlying cause of the condition. DNA is also used in forensic science to identify individuals based on their unique genetic fingerprint. This is because each person's DNA sequence is unique, and can be used to distinguish one individual from another. DNA analysis is also used in criminal investigations to help solve crimes by linking DNA evidence to suspects or victims.
Lung neoplasms refer to abnormal growths or tumors that develop in the lungs. These growths can be either benign (non-cancerous) or malignant (cancerous). Lung neoplasms can occur in any part of the lung, including the bronchi, bronchioles, and alveoli. Lung neoplasms can be further classified based on their type, including: 1. Primary lung neoplasms: These are tumors that develop in the lungs and do not spread to other parts of the body. 2. Secondary lung neoplasms: These are tumors that develop in the lungs as a result of cancer that has spread from another part of the body. 3. Benign lung neoplasms: These are non-cancerous tumors that do not spread to other parts of the body. 4. Malignant lung neoplasms: These are cancerous tumors that can spread to other parts of the body. Some common types of lung neoplasms include lung adenocarcinoma, squamous cell carcinoma, large cell carcinoma, and small cell carcinoma. The diagnosis of lung neoplasms typically involves a combination of imaging tests, such as chest X-rays and CT scans, and a biopsy to examine a sample of tissue from the tumor. Treatment options for lung neoplasms depend on the type, size, and location of the tumor, as well as the overall health of the patient.
In the medical field, the term "carbon" typically refers to the chemical element with the atomic number 6, which is a vital component of all living organisms. Carbon is the building block of organic molecules, including proteins, carbohydrates, lipids, and nucleic acids, which are essential for the structure and function of cells and tissues. In medicine, carbon is also used in various diagnostic and therapeutic applications. For example, carbon-13 (13C) is a stable isotope of carbon that is used in metabolic studies to investigate the function of enzymes and pathways in the body. Carbon-14 (14C) is a radioactive isotope of carbon that is used in radiocarbon dating to determine the age of organic materials, including human remains. Additionally, carbon dioxide (CO2) is a gas that is produced by the body during respiration and is exhaled. It is also used in medical applications, such as in carbon dioxide laser therapy, which uses the energy of CO2 lasers to treat various medical conditions, including skin disorders, tumors, and eye diseases.
RNA, Ribosomal, 16S is a type of ribosomal RNA (rRNA) that is found in bacteria and archaea. It is a small subunit of the ribosome, which is the cellular machinery responsible for protein synthesis. The 16S rRNA is located in the 30S subunit of the ribosome and is essential for the binding and decoding of messenger RNA (mRNA) during translation. The sequence of the 16S rRNA is highly conserved among bacteria and archaea, making it a useful target for the identification and classification of these organisms. In the medical field, the 16S rRNA is often used in molecular biology techniques such as polymerase chain reaction (PCR) and DNA sequencing to study the diversity and evolution of bacterial and archaeal populations. It is also used in the development of diagnostic tests for bacterial infections and in the identification of antibiotic-resistant strains of bacteria.
Heterocyclic compounds are organic compounds that contain at least one ring composed of atoms other than carbon. In the medical field, heterocyclic compounds are often used as pharmaceuticals due to their ability to interact with biological targets and produce therapeutic effects. Examples of heterocyclic compounds used in medicine include: 1. Pyrimidines: These are a class of heterocyclic compounds that include thymine, cytosine, and uracil. They are important components of DNA and RNA and are used in the development of antiviral and anticancer drugs. 2. Purines: These are another class of heterocyclic compounds that include adenine and guanine. They are also important components of DNA and RNA and are used in the development of antiviral and anticancer drugs. 3. Imidazoles: These are heterocyclic compounds that contain a nitrogen atom and a carbon atom in a six-membered ring. They are used in the development of antifungal and anti-inflammatory drugs. 4. Quinolines: These are heterocyclic compounds that contain a nitrogen atom and two carbon atoms in a six-membered ring. They are used in the development of antimalarial and antituberculosis drugs. Overall, heterocyclic compounds play an important role in the development of new drugs and therapies in the medical field.
Bacteria are single-celled microorganisms that are found in almost every environment on Earth, including soil, water, and the human body. In the medical field, bacteria are often studied and classified based on their characteristics, such as their shape, size, and genetic makeup. Bacteria can be either beneficial or harmful to humans. Some bacteria are essential for human health, such as the bacteria that live in the gut and help digest food. However, other bacteria can cause infections and diseases, such as strep throat, pneumonia, and meningitis. In the medical field, bacteria are often identified and treated using a variety of methods, including culturing and identifying bacteria using specialized laboratory techniques, administering antibiotics to kill harmful bacteria, and using vaccines to prevent bacterial infections.
In the medical field, amines are organic compounds that contain a nitrogen atom bonded to one or more carbon atoms. They are often used as drugs, either as medications or as intermediates in the synthesis of other drugs. Amines can be classified into several categories based on their chemical structure and properties. Some common types of amines include primary amines, secondary amines, and tertiary amines. Primary amines have one nitrogen atom bonded to one hydrogen atom and two carbon atoms. Examples of primary amines include histamine, which is involved in allergic reactions, and dopamine, which plays a role in the regulation of movement and mood. Secondary amines have one nitrogen atom bonded to two hydrogen atoms and one carbon atom. Examples of secondary amines include epinephrine, which is used to treat severe allergic reactions and asthma, and norepinephrine, which is involved in the regulation of blood pressure and heart rate. Tertiary amines have one nitrogen atom bonded to three carbon atoms. Examples of tertiary amines include trimethoprim, which is used to treat bacterial infections, and procainamide, which is used to treat certain types of heart arrhythmias. Amines can also be classified based on their physical properties, such as their solubility in water and their ability to form salts with acids. Some amines are water-soluble and can be used as electrolytes in intravenous solutions, while others are insoluble and are used as local anesthetics.
Prostaglandins A, Synthetic are a class of synthetic drugs that are similar in structure to the naturally occurring hormone prostaglandin A. Prostaglandins are hormone-like substances that are produced by cells in the body and play a role in a variety of physiological processes, including inflammation, pain, and blood clotting. Synthetic prostaglandins are used in a variety of medical treatments, including to induce labor in pregnant women, to treat certain types of stomach ulcers, and to prevent blood clots. They are also used to treat a variety of other conditions, such as asthma, chronic obstructive pulmonary disease (COPD), and glaucoma. Prostaglandins are administered through various routes, including injection, inhalation, and oral administration. They can cause side effects, such as nausea, vomiting, and diarrhea, and may interact with other medications. It is important for patients to follow their healthcare provider's instructions carefully when taking prostaglandins.
In the medical field, industrial waste refers to any waste materials generated during the production, processing, or distribution of medical products or services. This can include a wide range of materials, such as packaging materials, contaminated equipment, used needles and syringes, biological waste, and chemical waste. Medical industrial waste is considered hazardous because it can contain infectious agents, toxins, and other harmful substances that can pose a risk to human health and the environment if not properly managed. As a result, medical facilities are required to follow strict regulations and guidelines for the collection, storage, transportation, and disposal of medical industrial waste to ensure that it is handled safely and responsibly.
Occupational diseases are illnesses or injuries that are caused by exposure to hazards or conditions in the workplace. These hazards or conditions can include chemicals, dusts, fumes, radiation, noise, vibration, and physical demands such as repetitive motions or awkward postures. Occupational diseases can affect various systems in the body, including the respiratory system, skin, eyes, ears, cardiovascular system, and nervous system. Examples of occupational diseases include asbestosis, silicosis, coal workers' pneumoconiosis, carpal tunnel syndrome, and hearing loss. Occupational diseases are preventable through proper safety measures and regulations in the workplace. Employers are responsible for providing a safe and healthy work environment for their employees, and workers have the right to report hazards and seek medical attention if they experience any symptoms related to their work.
Tobacco smoke pollution refers to the presence of harmful chemicals and toxins in the air that are produced when tobacco is burned. These chemicals and toxins can be inhaled by people who are exposed to tobacco smoke, either directly or indirectly, and can cause a range of health problems. In the medical field, tobacco smoke pollution is often referred to as secondhand smoke or passive smoke. Secondhand smoke is the smoke that is exhaled by smokers and the smoke that is produced when tobacco is burned in cigarettes, cigars, or pipes. It can also include the smoke that is produced by e-cigarettes. Exposure to secondhand smoke has been linked to a number of serious health problems, including lung cancer, heart disease, stroke, and respiratory infections. It can also harm children, causing ear infections, bronchitis, and other health problems. In order to reduce the harmful effects of tobacco smoke pollution, it is important to create smoke-free environments, both indoors and outdoors. This can include laws that prohibit smoking in public places, as well as efforts to educate people about the dangers of tobacco smoke and the benefits of quitting smoking.
Xylenes are a group of four organic compounds that are commonly used as solvents in various industries, including the medical field. They are composed of benzene rings with one or two methyl groups attached to them. In the medical field, xylenes are used as anesthetic agents for surgical procedures. They are administered intravenously or inhaled to induce anesthesia and are used to reduce pain and discomfort during surgery. Xylenes are also used as a solvent in the production of certain medications, such as antibiotics and anti-inflammatory drugs. However, it is important to note that xylenes can be toxic and can cause adverse effects if not used properly. Exposure to high levels of xylenes can lead to respiratory problems, dizziness, nausea, and even death. Therefore, medical professionals must follow strict guidelines and safety protocols when using xylenes in their practice.
In the medical field, soot is a type of fine black or brown particulate matter that is produced by incomplete combustion of carbon-based fuels, such as coal, wood, and oil. Soot particles can be inhaled into the lungs and can cause a range of health problems, including respiratory irritation, inflammation, and damage to lung tissue. Long-term exposure to soot has been linked to an increased risk of chronic obstructive pulmonary disease (COPD), lung cancer, and cardiovascular disease. In some cases, soot exposure can also cause skin irritation and other dermatological problems.
Prenatal Exposure Delayed Effects (PEDs) refer to the long-term health effects that can occur in an individual as a result of exposure to environmental or genetic factors during pregnancy. PEDs can manifest in a variety of ways, including physical, behavioral, and cognitive impairments, and can occur even if the exposure occurred many years before the individual's birth. PEDs can result from exposure to a wide range of substances, including drugs, alcohol, tobacco, pollutants, and infections. These exposures can affect the developing fetus in various ways, including disrupting normal growth and development, altering gene expression, and causing damage to organs and systems. PEDs can also result from genetic factors, such as inherited disorders or mutations. These genetic factors can increase the risk of developing certain health conditions, such as autism, ADHD, and learning disabilities, even if the individual was not exposed to any environmental factors during pregnancy. Overall, PEDs highlight the importance of taking steps to protect pregnant women and their developing fetuses from exposure to harmful substances and environmental factors, as well as the need for ongoing monitoring and support for individuals who may be at risk for PEDs.
Case-control studies are a type of observational study used in the medical field to investigate the relationship between an exposure and an outcome. In a case-control study, researchers identify individuals who have experienced a particular outcome (cases) and compare their exposure history to a group of individuals who have not experienced the outcome (controls). The main goal of a case-control study is to determine whether the exposure was a risk factor for the outcome. To do this, researchers collect information about the exposure history of both the cases and the controls and compare the two groups to see if there is a statistically significant difference in the prevalence of the exposure between the two groups. Case-control studies are often used when the outcome of interest is rare, and it is difficult or unethical to conduct a prospective cohort study. However, because case-control studies rely on retrospective data collection, they are subject to recall bias, where participants may not accurately remember their exposure history. Additionally, because case-control studies only provide information about the association between an exposure and an outcome, they cannot establish causality.
Graphite is not typically used in the medical field. Graphite is a naturally occurring mineral that is composed of carbon atoms arranged in a hexagonal lattice structure. It is commonly used in pencils, as a lubricant, and in the production of electrodes for electrochemical cells. In the medical field, graphite is not commonly used for any medical purposes.
In the medical field, "China" typically refers to the People's Republic of China, which is a country located in East Asia. China has a large and diverse population, and its healthcare system is one of the largest in the world. The country has made significant progress in improving access to healthcare and reducing mortality rates in recent years. In terms of medical research and development, China has become an important player in the global biomedical community. The country has a growing number of research institutions and has made significant investments in medical research and development. China is also home to a large and diverse population, which provides a rich source of data for medical research. Overall, "China" in the medical field typically refers to the country's healthcare system, medical research and development, and its role in the global biomedical community.
Glutathione S-transferase pi (GSTP1) is an enzyme that plays a role in detoxifying harmful substances in the body. It is a member of the glutathione S-transferase (GST) family of enzymes, which are involved in the metabolism of a wide range of compounds, including drugs, toxins, and carcinogens. In the medical field, GSTP1 is often studied in relation to cancer. Some research has suggested that certain genetic variations in the GSTP1 gene may increase a person's risk of developing certain types of cancer, such as lung cancer and prostate cancer. GSTP1 is also being studied as a potential target for cancer therapy, as it may play a role in the development and progression of certain types of cancer. In addition to its role in cancer, GSTP1 is also involved in the metabolism of other substances, including drugs. Some drugs are metabolized by GSTP1, which can affect their effectiveness and potential side effects. As a result, GSTP1 is an important enzyme to consider when developing new drugs and evaluating their potential risks and benefits.
Toluene is a colorless, sweet-smelling liquid that is commonly used as a solvent in various industries, including the medical field. In the medical field, toluene is used as a topical anesthetic to numb the skin and reduce pain during medical procedures such as injections, wound care, and skin biopsies. It is also used as a component in some medications and as a cleaning agent for medical equipment. However, it is important to note that toluene can be toxic if ingested or inhaled in large amounts, and medical professionals are trained to use it safely and appropriately.
In the medical field, gases are substances that exist in a gaseous state at normal atmospheric pressure and temperature. Gases are typically composed of atoms or molecules that are highly energetic and move rapidly in all directions. Gases are important in medicine because they play a role in many physiological processes, such as respiration, circulation, and gas exchange. For example, oxygen is a gas that is essential for respiration, and carbon dioxide is a waste product that is exhaled from the body. In medical settings, gases can be used for a variety of purposes, such as anesthesia, oxygen therapy, and carbon dioxide removal. Gases can also be used in diagnostic tests, such as pulmonary function tests, which measure the amount of air that a person can inhale and exhale. It is important for healthcare professionals to be familiar with the properties and effects of different gases, as well as the proper handling and administration of gases in medical settings.
Charcoal is a black, porous material that is made by heating wood or other organic materials in the absence of air. In the medical field, charcoal is often used as an adsorbent to remove toxins and other harmful substances from the body. It is commonly used to treat poisoning from drugs, alcohol, or other substances, as well as to treat certain digestive disorders such as diarrhea and irritable bowel syndrome. Charcoal is available in various forms, including capsules, tablets, and powders, and is typically taken orally. It is important to note that charcoal should not be used as a substitute for medical treatment, and that it should only be used under the guidance of a healthcare professional.
In the medical field, mineral oil is a type of liquid hydrocarbon that is commonly used as a lubricant, emollient, and antiseptic. It is derived from petroleum and is composed of a mixture of hydrocarbons with carbon chain lengths ranging from C12 to C50. Mineral oil is often used in medical applications due to its low toxicity, low cost, and ability to form a protective barrier on the skin. It is commonly used as a lubricant for medical equipment, such as syringes and catheters, and as a topical ointment for treating dry skin, eczema, and other skin conditions. However, it is important to note that mineral oil can be comedogenic, meaning it can clog pores and cause acne breakouts in some individuals. Additionally, it is not recommended for use on wounds or open skin as it can slow down the healing process and increase the risk of infection.
Thioamides are a class of organic compounds that contain a sulfur atom bonded to an amide group. They are commonly used in the medical field as drugs and as intermediates in the synthesis of other drugs. Thioamides have a wide range of biological activities, including antimicrobial, antifungal, and antiviral properties. They are also used as diuretics, antithyroid agents, and as treatments for certain types of cancer. Some examples of thioamides used in medicine include thiocyanate, thiourea, and methimazole.
In the medical field, "tars" typically refers to the tarsal bones of the foot, which are the seven bones that make up the rear part of the foot. These bones are located between the ankle joint and the heel bone and are responsible for supporting the weight of the body and allowing for movement of the foot. The tarsal bones include the calcaneus (heel bone), talus, navicular, cuboid, medial cuneiform, intermediate cuneiform, and lateral cuneiform. Injuries or disorders of the tarsal bones can cause pain, swelling, and difficulty walking.
Air pollution refers to the presence of harmful substances in the air that can have negative effects on human health. These substances can include particulate matter, gases such as sulfur dioxide and nitrogen oxides, and volatile organic compounds. Exposure to air pollution can cause a range of health problems, including respiratory issues such as asthma and bronchitis, cardiovascular disease, and even cancer. In the medical field, air pollution is considered a significant public health concern, and efforts are being made to reduce exposure to these harmful substances through measures such as regulations on industrial emissions and the promotion of clean energy sources.
Gas chromatography (GC) is a technique used in the medical field to separate and analyze volatile compounds in a sample. It is a type of chromatography that uses a gas as the mobile phase to separate the components of a mixture based on their volatility and interaction with the stationary phase. In GC, a sample is injected into a heated column packed with a stationary phase, which is typically a solid or liquid coated onto a small diameter column. The sample components are then carried through the column by a carrier gas, such as helium or nitrogen, which flows through the column at a constant rate. As the sample components pass through the column, they interact with the stationary phase and are separated based on their volatility and affinity for the stationary phase. The separated components are then detected and quantified using a detector, such as a flame ionization detector or mass spectrometer. GC is commonly used in the medical field to analyze a wide range of samples, including biological fluids, drugs, and environmental samples. It is particularly useful for analyzing volatile organic compounds, such as those found in breath or blood, and is often used in the diagnosis and monitoring of diseases such as diabetes, liver disease, and lung cancer.
Phosphorus radioisotopes are radioactive isotopes of the element phosphorus that are used in medical imaging and treatment. These isotopes emit radiation that can be detected by medical imaging equipment, such as positron emission tomography (PET) scanners, to create images of the body's internal structures and functions. One commonly used phosphorus radioisotope in medical imaging is fluorine-18, which is produced by bombarding a target with protons. Fluorine-18 is then incorporated into a compound, such as fluorodeoxyglucose (FDG), which is taken up by cells in the body. The PET scanner detects the radiation emitted by the fluorine-18 in the FDG and creates an image of the areas of the body where the FDG is concentrated, which can help diagnose conditions such as cancer, heart disease, and neurological disorders. Phosphorus radioisotopes are also used in radiation therapy to treat certain types of cancer. For example, strontium-89 is a phosphorus radioisotope that emits beta particles that can destroy cancer cells. It is often used to treat bone metastases, which are cancerous tumors that have spread to the bones.
Glycine N-methyltransferase (GNMT) is an enzyme that plays a crucial role in the metabolism of glycine, an amino acid that is involved in various biological processes, including the synthesis of proteins, neurotransmitters, and bile acids. GNMT catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to glycine, forming sarcosine and S-adenosylhomocysteine (SAH). SAH is then hydrolyzed to homocysteine and adenosine, which can be recycled back to SAM through the methionine cycle. In the medical field, GNMT has been implicated in various diseases, including cancer, neurodegenerative disorders, and metabolic disorders. For example, mutations in the GNMT gene have been associated with a rare inherited disorder called methylmalonic acidemia, which is characterized by elevated levels of methylmalonic acid in the blood and urine. Additionally, studies have suggested that GNMT may play a role in the development of certain types of cancer, such as breast and prostate cancer, by regulating the levels of certain signaling molecules and hormones.
In the medical field, "Metals, Heavy" typically refers to a group of elements that are dense, have high atomic numbers, and are toxic or harmful to human health when ingested, inhaled, or absorbed through the skin. Examples of heavy metals include lead, mercury, cadmium, chromium, and arsenic. Heavy metals can accumulate in the body over time and cause a range of health problems, including neurological disorders, kidney damage, and cancer. Exposure to heavy metals can occur through various sources, such as contaminated water, soil, air, and food. In medical settings, heavy metal exposure may be diagnosed through blood, urine, or hair tests, and treatment may involve chelation therapy to remove the metals from the body or other supportive care to manage symptoms. Prevention of heavy metal exposure is also important, and may involve avoiding contaminated sources of food and water, using protective equipment in certain industries, and following safe handling and disposal practices for heavy metal-containing materials.
Cotinine is a metabolite of nicotine, a chemical found in tobacco products. It is produced in the body when nicotine is broken down by enzymes in the liver and lungs. Cotinine is often used as a biomarker for tobacco use, as it can be detected in the blood, urine, and hair of people who smoke or use other tobacco products. In the medical field, cotinine levels can be measured to help diagnose and monitor tobacco use, as well as to assess the effectiveness of smoking cessation treatments. High levels of cotinine in the blood or urine may indicate recent or heavy tobacco use, while low levels may suggest that a person has quit smoking.
Benzene derivatives are chemical compounds that are derived from benzene, which is a common organic compound with the chemical formula C6H6. Benzene derivatives are widely used in the medical field for a variety of purposes, including as drugs, as intermediates in the synthesis of other drugs, and as chemical reagents in medical research. Some examples of benzene derivatives that are used in medicine include anesthetics, analgesics, anti-inflammatory drugs, and anticancer drugs. For example, benzene derivatives such as lidocaine and procaine are commonly used as local anesthetics to numb the skin and other tissues during medical procedures. Other benzene derivatives, such as aspirin and ibuprofen, are used as nonsteroidal anti-inflammatory drugs (NSAIDs) to relieve pain, reduce inflammation, and lower fever. Benzene derivatives are also used in the synthesis of other drugs, such as antibiotics, antihistamines, and antidepressants. In addition, benzene derivatives are used as chemical reagents in medical research to study the mechanisms of various biological processes and to develop new drugs and therapies. It is important to note that benzene is a known carcinogen, and exposure to high levels of benzene can cause a range of health problems, including leukemia and other blood disorders. As a result, benzene derivatives must be handled with care in the medical field, and appropriate safety measures must be taken to prevent exposure to benzene and its derivatives.
DNA, ribosomal, refers to the specific type of DNA found within ribosomes, which are the cellular structures responsible for protein synthesis. Ribosomal DNA (rDNA) is transcribed into ribosomal RNA (rRNA), which then forms the core of the ribosome. The rRNA molecules are essential for the assembly and function of the ribosome, and the rDNA sequences that code for these molecules are highly conserved across different species. Mutations in rDNA can lead to defects in ribosome function and can be associated with various medical conditions, including some forms of cancer and inherited disorders.
The comet assay, also known as the single-cell gel electrophoresis (SCGE) assay, is a laboratory technique used to detect DNA damage in individual cells. It is a sensitive and rapid method that can be used to assess DNA damage in a variety of cell types, including blood cells, skin cells, and cells from various organs. The comet assay involves lysing (breaking open) the cell and allowing the DNA to unwind and form a "comet" shape under the influence of an electric field. The length and intensity of the comet tail, which is formed by the DNA that has been damaged, can be used to quantify the amount of DNA damage in the cell. The comet assay is often used in toxicology to assess the genotoxic (DNA-damaging) effects of chemicals, radiation, and other environmental factors. It can also be used in clinical settings to monitor DNA damage in patients with certain diseases, such as cancer, and to assess the effectiveness of treatments.
Lead radioisotopes are radioactive isotopes of the element lead that are used in medical imaging and therapy. These isotopes emit radiation that can be detected by medical imaging equipment, such as gamma cameras, to create images of the body's internal structures. One commonly used lead radioisotope in medical imaging is lead-203, which emits low-energy gamma rays that can be detected by gamma cameras to create high-resolution images of the body's organs and tissues. Lead-203 is often used in diagnostic imaging of the liver, spleen, and bone marrow. Lead radioisotopes are also used in radiation therapy to treat certain types of cancer. For example, lead-212 is a short-lived alpha-emitting radioisotope that can be used to treat small tumors in the head and neck. The alpha particles emitted by lead-212 are highly ionizing and can damage cancer cells, while minimizing damage to surrounding healthy tissue. Overall, lead radioisotopes play an important role in medical imaging and therapy, allowing doctors to diagnose and treat a wide range of medical conditions.
In the medical field, "air" typically refers to the mixture of gases that make up the Earth's atmosphere, which is composed primarily of nitrogen (78%) and oxygen (21%), with trace amounts of other gases such as carbon dioxide, argon, and neon. In medical contexts, air can refer to the inhalation of air into the lungs, which is necessary for respiration and the exchange of oxygen and carbon dioxide. Air can also refer to the presence of air in the body, such as in the case of pneumothorax, where air leaks into the space between the lung and the chest wall, causing the lung to collapse. In some medical procedures, such as bronchoscopy or endoscopy, air is used to inflate the airways and create a clear view of the inside of the body. In other cases, air may be used as a contrast medium to help visualize certain structures on medical imaging studies, such as X-rays or CT scans.
Hydrolyzable tannins are a type of polyphenolic compound found in many plants, including fruits, vegetables, nuts, and grains. They are also known as "water-soluble tannins" because they can be easily dissolved in water. In the medical field, hydrolyzable tannins have been studied for their potential health benefits. Some of the potential benefits of hydrolyzable tannins include: 1. Anti-inflammatory effects: Hydrolyzable tannins have been shown to have anti-inflammatory properties, which may help to reduce inflammation in the body. 2. Antioxidant effects: Hydrolyzable tannins are also antioxidants, which means they can help to protect the body against damage from free radicals. 3. Anti-cancer effects: Some studies have suggested that hydrolyzable tannins may have anti-cancer properties, although more research is needed to confirm this. 4. Anti-bacterial and anti-viral effects: Hydrolyzable tannins have been shown to have anti-bacterial and anti-viral properties, which may help to protect the body against infections. Overall, hydrolyzable tannins are a type of polyphenolic compound that have potential health benefits, although more research is needed to fully understand their effects on the body.
Oxidoreductases are a class of enzymes that catalyze redox reactions, which involve the transfer of electrons from one molecule to another. These enzymes play a crucial role in many biological processes, including metabolism, energy production, and detoxification. In the medical field, oxidoreductases are often studied in relation to various diseases and conditions. For example, some oxidoreductases are involved in the metabolism of drugs and toxins, and changes in their activity can affect the efficacy and toxicity of these substances. Other oxidoreductases are involved in the production of reactive oxygen species (ROS), which can cause cellular damage and contribute to the development of diseases such as cancer and aging. Oxidoreductases are also important in the diagnosis and treatment of certain diseases. For example, some oxidoreductases are used as markers of liver disease, and changes in their activity can indicate the severity of the disease. In addition, some oxidoreductases are targets for drugs used to treat diseases such as cancer and diabetes. Overall, oxidoreductases are a diverse and important class of enzymes that play a central role in many biological processes and are the subject of ongoing research in the medical field.
In the medical field, the term "atmosphere" typically refers to the physical environment or conditions in a particular setting, such as a hospital room or a surgical suite. The atmosphere can have a significant impact on the patient's experience, comfort, and overall well-being. For example, a calm and peaceful atmosphere can help reduce anxiety and promote relaxation, while a noisy and chaotic atmosphere can increase stress and discomfort. Similarly, a clean and well-lit atmosphere can promote healing and prevent infections, while a dirty or poorly lit atmosphere can have the opposite effect. In addition to the physical environment, the atmosphere can also refer to the emotional or social environment. For example, a supportive and caring atmosphere can help patients feel more comfortable and confident in their care, while a or dismissive atmosphere can have the opposite effect. Overall, creating a positive atmosphere is an important aspect of patient-centered care, and healthcare providers strive to create an environment that is safe, comfortable, and conducive to healing.
DNA, Bacterial refers to the genetic material of bacteria, which is a type of single-celled microorganism that can be found in various environments, including soil, water, and the human body. Bacterial DNA is typically circular in shape and contains genes that encode for the proteins necessary for the bacteria to survive and reproduce. In the medical field, bacterial DNA is often studied as a means of identifying and diagnosing bacterial infections. Bacterial DNA can be extracted from samples such as blood, urine, or sputum and analyzed using techniques such as polymerase chain reaction (PCR) or DNA sequencing. This information can be used to identify the specific type of bacteria causing an infection and to determine the most effective treatment. Bacterial DNA can also be used in research to study the evolution and diversity of bacteria, as well as their interactions with other organisms and the environment. Additionally, bacterial DNA can be modified or manipulated to create genetically engineered bacteria with specific properties, such as the ability to produce certain drugs or to degrade pollutants.
Benzopyrene Hydroxylase (CYP1A1) is an enzyme that plays a crucial role in the metabolism of polycyclic aromatic hydrocarbons (PAHs), including the potent carcinogen benzo[a]pyrene. It is encoded by the CYP1A1 gene and is primarily expressed in the liver, lungs, and skin. The primary function of CYP1A1 is to catalyze the hydroxylation of PAHs, which converts them into more polar and water-soluble metabolites that can be more easily excreted from the body. This process is an important step in the body's defense against the toxic and carcinogenic effects of PAHs. Deficiency or mutations in the CYP1A1 gene can lead to reduced activity of the enzyme, which can result in increased susceptibility to PAH-induced toxicity and cancer. In addition, exposure to certain environmental factors, such as cigarette smoke and air pollution, can induce the expression of CYP1A1, leading to increased metabolism of PAHs and potentially increased cancer risk.
In the medical field, "air movements" typically refers to the process of breathing, which involves the movement of air in and out of the lungs. This process is essential for the exchange of oxygen and carbon dioxide, which are necessary for the body's metabolic processes. Air movements are controlled by the respiratory system, which includes the lungs, diaphragm, and muscles of the chest and abdomen. When we inhale, the diaphragm and intercostal muscles contract, causing the chest cavity to expand and air to flow into the lungs. When we exhale, the diaphragm and intercostal muscles relax, causing the chest cavity to contract and air to flow out of the lungs. In some medical contexts, "air movements" may also refer to the movement of air through the respiratory tract, including the nose, mouth, pharynx, larynx, trachea, bronchi, and bronchioles. This movement of air is important for the delivery of oxygen to the lungs and the removal of carbon dioxide from the body. Any obstruction or blockage in the respiratory tract can interfere with air movements and lead to breathing difficulties or other respiratory problems.
In the medical field, a base sequence refers to the specific order of nucleotides (adenine, thymine, cytosine, and guanine) that make up the genetic material (DNA or RNA) of an organism. The base sequence determines the genetic information encoded within the DNA molecule and ultimately determines the traits and characteristics of an individual. The base sequence can be analyzed using various techniques, such as DNA sequencing, to identify genetic variations or mutations that may be associated with certain diseases or conditions.
Phenols are a class of organic compounds that contain a hydroxyl (-OH) group attached to an aromatic ring. In the medical field, phenols are commonly used as antiseptics and disinfectants due to their ability to kill bacteria, viruses, and fungi. They are also used as topical anesthetics and as ingredients in certain medications. Phenols can be found naturally in many plants and fruits, such as cloves, cinnamon, and citrus fruits. They are also used in the production of a variety of consumer products, including soaps, shampoos, and cleaning agents. However, some phenols can be toxic and can cause skin irritation, respiratory problems, and other health issues if they are not used properly. Therefore, it is important to follow proper safety guidelines when handling and using phenols in the medical field.
Glucuronosyltransferase (UGT) is a group of enzymes that play a crucial role in the metabolism of various endogenous and exogenous substances in the body. These enzymes catalyze the transfer of a glucuronic acid residue from UDP-glucuronic acid to a wide range of substrates, including drugs, toxins, and hormones. In the medical field, UGT enzymes are important because they can affect the pharmacokinetics and pharmacodynamics of drugs. For example, some drugs are metabolized by UGT enzymes, which can affect their efficacy, toxicity, and duration of action. In addition, UGT enzymes can also play a role in the metabolism of endogenous substances, such as bile acids and steroid hormones. Dysfunction of UGT enzymes can lead to various medical conditions, including drug toxicity, drug resistance, and metabolic disorders. For example, genetic defects in UGT enzymes can result in reduced enzyme activity, leading to increased drug toxicity or decreased drug efficacy. In addition, certain medications can also inhibit or induce UGT enzymes, leading to changes in drug metabolism and potential adverse effects. Overall, UGT enzymes are an important group of enzymes in the body that play a critical role in drug metabolism and the metabolism of various endogenous substances. Understanding the function and regulation of UGT enzymes is important for the development of new drugs and the optimization of drug therapy.
In the medical field, adsorption refers to the process by which a substance adheres or sticks to the surface of another substance. This can occur when a drug or other therapeutic agent is adsorbed onto a surface, such as a medical device or a patient's skin. Adsorption can also occur when a substance is adsorbed onto the surface of a cell or tissue, which can affect its ability to interact with the body's immune system or other cells. Adsorption can be an important factor in the development and delivery of medical treatments, as it can affect the effectiveness and safety of a drug or other therapeutic agent.
Mixed-function oxygenases are a class of enzymes that catalyze the oxidation of a wide range of substrates, including drugs, toxins, and endogenous compounds. These enzymes typically contain a non-heme iron or copper atom in their active site, which is coordinated by a variety of amino acid residues. Mixed-function oxygenases are involved in a variety of biological processes, including drug metabolism, xenobiotic detoxification, and the synthesis of important biological molecules such as cholesterol and bile acids. They are also involved in the metabolism of many environmental pollutants, including polycyclic aromatic hydrocarbons and halogenated hydrocarbons. In the medical field, mixed-function oxygenases are important because they play a key role in the metabolism of many drugs, which can affect their efficacy and toxicity. For example, the cytochrome P450 family of mixed-function oxygenases is responsible for the metabolism of many commonly prescribed drugs, including anti-inflammatory drugs, antidepressants, and anticoagulants. Understanding the role of these enzymes in drug metabolism is important for optimizing drug therapy and minimizing adverse drug reactions.
In the medical field, "Cells, Cultured" refers to cells that have been grown and maintained in a controlled environment outside of their natural biological context, typically in a laboratory setting. This process is known as cell culture and involves the isolation of cells from a tissue or organism, followed by their growth and proliferation in a nutrient-rich medium. Cultured cells can be derived from a variety of sources, including human or animal tissues, and can be used for a wide range of applications in medicine and research. For example, cultured cells can be used to study the behavior and function of specific cell types, to develop new drugs and therapies, and to test the safety and efficacy of medical products. Cultured cells can be grown in various types of containers, such as flasks or Petri dishes, and can be maintained at different temperatures and humidity levels to optimize their growth and survival. The medium used to culture cells typically contains a combination of nutrients, growth factors, and other substances that support cell growth and proliferation. Overall, the use of cultured cells has revolutionized medical research and has led to many important discoveries and advancements in the field of medicine.
In the medical field, aerosols refer to tiny particles or droplets of liquid or solid matter that are suspended in the air and can be inhaled into the respiratory system. Aerosols can be generated by various sources, including human activities such as talking, coughing, and sneezing, as well as natural phenomena such as volcanic eruptions and dust storms. Aerosols can contain a variety of substances, including bacteria, viruses, fungi, pollutants, and other particles. When inhaled, these particles can enter the lungs and potentially cause respiratory infections, allergies, and other health problems. In the context of infectious diseases, aerosols are of particular concern because they can transmit pathogens over long distances and remain suspended in the air for extended periods of time. To prevent the spread of infectious diseases, it is important to take measures to reduce the generation and dispersion of aerosols in indoor environments, such as wearing masks, practicing good respiratory hygiene, and improving ventilation systems.
Laccase is an enzyme that belongs to the family of multicopper oxidases. It is produced by a variety of organisms, including fungi, bacteria, and plants. In the medical field, laccase has been studied for its potential applications in various areas, including: 1. Bioremediation: Laccase can break down a wide range of environmental pollutants, including phenols, dyes, and pesticides. It has been used in bioremediation to clean up contaminated soil and water. 2. Wastewater treatment: Laccase can be used to degrade organic pollutants in wastewater, making it a potential alternative to traditional chemical treatments. 3. Bioprinting: Laccase has been used in bioprinting to create 3D structures using living cells. It can crosslink biopolymers, such as alginate, to create stable structures. 4. Cancer treatment: Laccase has been shown to have anti-cancer properties and has been studied as a potential therapeutic agent for various types of cancer. 5. Drug delivery: Laccase can be used to modify the surface of drug delivery vehicles, such as nanoparticles, to improve their targeting and efficacy. Overall, laccase has a wide range of potential applications in the medical field, and ongoing research is exploring its full potential.
Chemical fractionation is a process used in the medical field to separate and purify different components of a mixture. This process involves the use of chemical reactions to selectively separate compounds based on their chemical properties, such as their solubility, polarity, or reactivity. In the medical field, chemical fractionation is commonly used to isolate and purify active compounds from natural sources, such as plants or animals, for use in the development of new drugs or therapies. For example, the active compounds in plants may be extracted using solvents, and then separated and purified using chemical fractionation techniques to isolate the specific compounds that are responsible for the desired therapeutic effects. Chemical fractionation can also be used to purify and separate different components of a mixture of drugs or other therapeutic agents, in order to optimize their effectiveness or reduce potential side effects. This process may involve the use of various chemical reactions, such as acid-base reactions, oxidation-reduction reactions, or precipitation reactions, to selectively separate the desired compounds from the mixture.
In the medical field, "Hydrocarbons, Alicyclic" refers to a group of organic compounds that are composed solely of hydrogen and carbon atoms, and have a cyclic structure. These compounds are also known as alicyclic hydrocarbons or cycloalkanes. Alicyclic hydrocarbons are commonly found in nature and are used in a variety of applications, including as solvents, fuels, and pharmaceuticals. They are also used in the production of plastics, resins, and other materials. In the medical field, alicyclic hydrocarbons may be used as ingredients in medications or as solvents for other drugs. They may also be used as diagnostic agents in imaging studies, such as magnetic resonance imaging (MRI). It is important to note that some alicyclic hydrocarbons can be toxic and may cause adverse effects when inhaled, ingested, or absorbed through the skin. Therefore, proper handling and disposal of these compounds is important to prevent exposure and minimize the risk of harm.
Micronuclei, chromosome-defective are small nuclear bodies that contain chromosomal material that has not been incorporated into the main nucleus of a cell. They are often formed as a result of DNA damage or errors in cell division, and can be used as a biomarker of genomic instability and cancer risk. In the medical field, the presence of micronuclei, chromosome-defective can be used to assess the genotoxicity of environmental or occupational exposures, as well as to monitor the effectiveness of cancer treatments.
In the medical field, isoenzymes refer to different forms of enzymes that have the same chemical structure and catalytic activity, but differ in their amino acid sequence. These differences can arise due to genetic variations or post-translational modifications, such as phosphorylation or glycosylation. Isoenzymes are often used in medical diagnosis and treatment because they can provide information about the function and health of specific organs or tissues. For example, the presence of certain isoenzymes in the blood can indicate liver or kidney disease, while changes in the levels of specific isoenzymes in the brain can be indicative of neurological disorders. In addition, isoenzymes can be used as biomarkers for certain diseases or conditions, and can be targeted for therapeutic intervention. For example, drugs that inhibit specific isoenzymes can be used to treat certain types of cancer or heart disease.
Alcohol oxidoreductases are a group of enzymes that catalyze the oxidation of alcohols. In the medical field, these enzymes are of particular interest because they play a key role in the metabolism of alcohol in the body. There are several different types of alcohol oxidoreductases, including alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). ADH is responsible for converting alcohol (ethanol) into acetaldehyde, a toxic substance that can cause a range of symptoms when present in high concentrations, including headache, nausea, and dizziness. ALDH is responsible for converting acetaldehyde into acetate, a non-toxic substance that can be further metabolized by the body. Alcohol oxidoreductases are found in a variety of tissues throughout the body, including the liver, brain, and lungs. In the liver, ADH and ALDH are particularly important for metabolizing alcohol, as this organ is responsible for processing a large amount of the alcohol that is consumed. Disruptions in the activity of alcohol oxidoreductases can lead to a range of health problems, including alcohol dependence, liver disease, and certain types of cancer. For example, individuals who are unable to effectively metabolize alcohol due to a deficiency in ADH or ALDH may be more susceptible to the negative effects of alcohol consumption, such as liver damage and addiction.
20-Hydroxysteroid dehydrogenases (20-HSDs) are a group of enzymes that play a crucial role in the metabolism of various hormones, including cortisol, aldosterone, and androgens. These enzymes are responsible for converting the active forms of these hormones into their inactive forms, which are then excreted from the body. In the medical field, 20-HSDs are often studied in the context of various diseases and disorders, including Cushing's syndrome, Addison's disease, and polycystic ovary syndrome (PCOS). In Cushing's syndrome, for example, the overproduction of cortisol is often caused by a malfunction in the 20-HSD enzyme responsible for converting cortisol to its inactive form. In Addison's disease, the deficiency of this enzyme can lead to a deficiency in cortisol production. In PCOS, the activity of 20-HSD enzymes has been shown to be altered, leading to an imbalance in the levels of androgens and estrogens. This can contribute to the development of symptoms such as irregular menstrual cycles, excess hair growth, and infertility. Overall, 20-HSDs play a critical role in regulating hormone levels in the body, and their dysfunction can have significant implications for various medical conditions.
Phenobarbital is a barbiturate medication that is primarily used to treat seizures, particularly in people with epilepsy. It is also used to treat anxiety, insomnia, and other conditions that cause restlessness or agitation. Phenobarbital works by increasing the activity of gamma-aminobutyric acid (GABA), a neurotransmitter that helps to calm the brain and reduce seizures. It is available in both oral and injectable forms and is typically taken several times a day. Phenobarbital can cause side effects such as drowsiness, dizziness, and nausea, and it may interact with other medications. It is important to take phenobarbital exactly as prescribed by a healthcare provider to avoid the risk of side effects or overdose.
In the medical field, "quartz" typically refers to a type of mineral that is commonly used in the production of medical devices and instruments. Quartz is a hard, crystalline mineral that is composed of silicon dioxide (SiO2) and is known for its high refractive index, which makes it useful for producing lenses and other optical components. Quartz is often used in the production of medical devices such as microscopes, spectrometers, and lasers. It is also used in the manufacture of surgical instruments, such as scalpels and forceps, due to its durability and resistance to corrosion. In addition to its use in medical devices, quartz is also used in the production of certain types of medical implants, such as dental fillings and orthopedic implants. However, it is important to note that the use of quartz in medical implants is relatively uncommon, and other materials such as titanium and stainless steel are more commonly used for this purpose.
A biological assay is a laboratory technique used to measure the biological activity of a substance, such as a drug or a protein. It involves exposing a biological system, such as cells or tissues, to the substance and measuring the resulting response. The response can be anything from a change in cell growth or survival to a change in gene expression or protein activity. Biological assays are used in a variety of fields, including pharmacology, toxicology, and biotechnology, to evaluate the effectiveness and safety of drugs, to study the function of genes and proteins, and to develop new therapeutic agents.
In the medical field, neoplasms refer to abnormal growths or tumors of cells that can occur in any part of the body. These growths can be either benign (non-cancerous) or malignant (cancerous). Benign neoplasms are usually slow-growing and do not spread to other parts of the body. They can cause symptoms such as pain, swelling, or difficulty moving the affected area. Examples of benign neoplasms include lipomas (fatty tumors), hemangiomas (vascular tumors), and fibromas (fibrous tumors). Malignant neoplasms, on the other hand, are cancerous and can spread to other parts of the body through the bloodstream or lymphatic system. They can cause a wide range of symptoms, depending on the location and stage of the cancer. Examples of malignant neoplasms include carcinomas (cancers that start in epithelial cells), sarcomas (cancers that start in connective tissue), and leukemias (cancers that start in blood cells). The diagnosis of neoplasms typically involves a combination of physical examination, imaging tests (such as X-rays, CT scans, or MRI scans), and biopsy (the removal of a small sample of tissue for examination under a microscope). Treatment options for neoplasms depend on the type, stage, and location of the cancer, as well as the patient's overall health and preferences.
In the medical field, RNA, Messenger (mRNA) refers to a type of RNA molecule that carries genetic information from DNA in the nucleus of a cell to the ribosomes, where proteins are synthesized. During the process of transcription, the DNA sequence of a gene is copied into a complementary RNA sequence called messenger RNA (mRNA). This mRNA molecule then leaves the nucleus and travels to the cytoplasm of the cell, where it binds to ribosomes and serves as a template for the synthesis of a specific protein. The sequence of nucleotides in the mRNA molecule determines the sequence of amino acids in the protein that is synthesized. Therefore, changes in the sequence of nucleotides in the mRNA molecule can result in changes in the amino acid sequence of the protein, which can affect the function of the protein and potentially lead to disease. mRNA molecules are often used in medical research and therapy as a way to introduce new genetic information into cells. For example, mRNA vaccines work by introducing a small piece of mRNA that encodes for a specific protein, which triggers an immune response in the body.
In the medical field, a cell line refers to a group of cells that have been derived from a single parent cell and have the ability to divide and grow indefinitely in culture. These cells are typically grown in a laboratory setting and are used for research purposes, such as studying the effects of drugs or investigating the underlying mechanisms of diseases. Cell lines are often derived from cancerous cells, as these cells tend to divide and grow more rapidly than normal cells. However, they can also be derived from normal cells, such as fibroblasts or epithelial cells. Cell lines are characterized by their unique genetic makeup, which can be used to identify them and compare them to other cell lines. Because cell lines can be grown in large quantities and are relatively easy to maintain, they are a valuable tool in medical research. They allow researchers to study the effects of drugs and other treatments on specific cell types, and to investigate the underlying mechanisms of diseases at the cellular level.
In the medical field, water is a vital substance that is essential for the proper functioning of the human body. It is a clear, odorless, tasteless liquid that makes up the majority of the body's fluids, including blood, lymph, and interstitial fluid. Water plays a crucial role in maintaining the body's temperature, transporting nutrients and oxygen to cells, removing waste products, and lubricating joints. It also helps to regulate blood pressure and prevent dehydration, which can lead to a range of health problems. In medical settings, water is often used as a means of hydration therapy for patients who are dehydrated or have fluid imbalances. It may also be used as a diluent for medications or as a component of intravenous fluids. Overall, water is an essential component of human health and plays a critical role in maintaining the body's normal functions.
Asbestos is a group of six naturally occurring minerals that were widely used in construction and manufacturing industries due to their heat-resistant and fireproof properties. However, asbestos fibers can be easily released into the air when materials containing asbestos are disturbed, and prolonged exposure to these fibers can cause serious health problems. In the medical field, asbestos exposure is associated with several types of cancer, including mesothelioma, lung cancer, and ovarian cancer. Mesothelioma is a rare and aggressive cancer that affects the lining of the lungs, chest wall, or abdominal cavity, and is almost always caused by exposure to asbestos. Asbestos-related diseases typically take many years to develop after exposure, and there is currently no known cure for mesothelioma. Treatment options may include surgery, chemotherapy, and radiation therapy, but the prognosis for individuals with mesothelioma is generally poor. In recent years, there has been a growing awareness of the dangers of asbestos, and many countries have banned or restricted its use. However, asbestos remains a significant public health concern in some parts of the world, and efforts are ongoing to identify and eliminate asbestos-containing materials in buildings and other structures.
Elizabeth Canuel
Methylcholanthrene
Myricetin
Elizabeth River (Virginia)
Polycyclic aromatic hydrocarbon
Homebush Bay
Dicoronylene
Benzo(c)fluorene
Contorted aromatics
Paleobiota of the Ciechocinek Formation
Chevron Richmond Refinery
River Fane
Abiogenesis
Hamilton Harbour
Long Island Sound
Oceanic carbon cycle
Evidence of common descent
Oroville, California
Corexit
Beluga whale
Environmental toxicants and fetal development
Exxon Valdez oil spill
Gulf of Finland
River Mersey
Hamilton-Oshawa Port Authority
In situ capping of subaqueous waste
Respecting Aboriginal Values & Environmental Needs
Deepwater Horizon oil spill
Readville station
Niger Delta mangroves
Polycyclic Aromatic Hydrocarbons (PAHs): What Are Polycyclic Aromatic Hydrocarbons (PAHs)? | Environmental Medicine | ATSDR
Elizabeth Canuel - Wikipedia
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DeCS 2009 - Changed terms
DeCS 2009 - Changed terms
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Review: The Use of Bench-Scale Tests to Determine Toxic Organic Compounds in Fire Effluents and to Subsequently Estimate Their...
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Influence of Machine-Derived Smoke Yields on Biomarker of Exposure (BOE) Levels in Cigarette Smokers*
DeCS 2017 - July 04, 2017 version
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Biblio | College of Agricultural Sciences
Biblio | College of Agricultural Sciences
Health effects of environmental pollution in population living near industrial complex areas in Korea
Water pipe smoking is 'less safe' than commonly thought
Research Paper Samlpe: Oil Trade and Environment in Alberta | SpeedyPaper.com
ocean acidification | Olympic Peninsula Environmental News | Page 2
When Can We Eat the Fish? | Michigan Tech Magazines
Can low pergesterone cause long heavy periods or a constant period (sometimes very light and then sometimes very heavy but...
PAHs5
- Polycyclic Aromatic Hydrocarbons (PAHs): What Are Polycyclic Aromatic Hydrocarbons (PAHs)? (cdc.gov)
- Structural Formulas of Selected Polycyclic Aromatic Hydrocarbons (PAHs). (cdc.gov)
- Because Barataria Bay was hit hard by the spill, Paruk's teams have been taking blood samples from the birds they capture, looking specifically for polycyclic aromatic hydrocarbons, or PAHs. (nwf.org)
- The class of hydrocarbons most toxic to wildlife, PAHs cause a range of health problems, including anemia, liver damage, cancer and immunosuppression. (nwf.org)
- That loons had significantly more PAHs in their blood three years after the spill than immediately following it suggests that hydrocarbons may be making their way up the food chain , Paruk says. (nwf.org)
Compounds2
- Personal breathing zone and area air samples were collected and analyzed for total particulate (TP), benzene soluble fraction (BSF) of the TP, and total polycyclic aromatic compounds (PAC). (cdc.gov)
- Complexes with large-scale industrial activities are stationary sources of various environmental pollutants, such as fine dust, sulfur dioxide (SO 2 ), nitrogen dioxide (NO 2 ), carbon monoxide (CO), ozone (O 3 ), volatile organic compounds (VOC), polycyclic aromatic hydrocarbons (PAH), and heavy metals [ 4 ]. (eaht.org)
Volatile1
- Despite a popular opinion that water pipe smoking is less harmful than cigarette smoking, water pipe users are exposed to significant levels of carbon monoxide, nicotine, tobacco-specific nitrosamines (TSNA), carcinogenic polycyclic aromatic hydrocarbons and volatile aldehydes over the duration of the smoking session. (medicalnewstoday.com)
ATSDR4
- Residents living within a 36-acre area of Tiverton, R.I., may have been exposed to arsenic, lead, mercury, and polycyclic aromatic hydrocarbons, says a final public health consultation released today by the Agency for Toxic Substances and Disease Registry (ATSDR). (cdc.gov)
- ATSDR categorized the Bay Street Tiverton Study Area as an "indeterminate public health hazard" because critical information is lacking. (cdc.gov)
- For more information, community members can contact ATSDR Environmental Health Scientist Jane Zhu toll-free, at 1-888-422-8737 or Kate Robbins, ATSDR Region 1 regional representative, at 617-918-1493. (cdc.gov)
- A report released by the federal Agency for Toxic Substances and Disease Registry (ATSDR) says that residents living within a 36-acre area of Tiverton could have been exposed to soil contaminated with arsenic, lead, mercury, and polycyclic aromatic hydrocarbons in the past and present. (cdc.gov)
Organic matter3
- She has examined the degradation of organic matter newly-placed on sediments, and anoxia in the Chesapeake Bay. (wikipedia.org)
- Her research in Chesapeake Bay also considers how the source of organic matter to the bay impacts water quality. (wikipedia.org)
- Canuel's use of stable isotopes extends to examining stable isotope ratios in plants from San Francisco Bay, the use of stable isotopes to track sources of organic matter in estuaries, and examining the age of organic matter in estuaries. (wikipedia.org)
Sediments1
- Corrigendum to "Polycyclic aromatic hydrocarbon status in post-hurricane Harvey sediments: Considerations for environmental sampling in the Galveston Bay/Houston Ship Channel region" [Mar. Pollut. (bvsalud.org)
Francisco Bay2
- The participants provided a urine sample before smoking water pipes at a hookah bar of their choice in the San Francisco Bay area. (medicalnewstoday.com)
- The aim of this study was to identify the knowledge, attitudes, and practices of hookah smokers in the San Francisco Bay Area. (who.int)
Seasonal2
Populations1
- Judith Perlinger , professor of environmental engineering , is the lead researcher of a project funded by the National Science Foundation (NSF) that set out to investigate the migration of ASEPs around the world and its local impact on people, especially in fish-reliant populations like the Keweenaw Bay Indian Community (KBIC). (mtu.edu)
Mediterranean2
- Studies report that in some regions, such as the US, Europe and the eastern Mediterranean, there has been a significant recent increase in water pipe smoking, particularly among the young. (medicalnewstoday.com)
- We estimated pollution in Lake Edku and the Mediterranean Sea, El-Maadiya Region, with 3 aromatic amines (1-naphthylamine, 2-naphthylamine and benzidine) in the muscle tissue of fish. (who.int)
Levels1
- According to the finding of University of Toronto research team that studied the levels of chemicals released from the sand when oil is mined-polycyclic aromatic hydrocarbons (PAH)- the estimated levels that were projected to be released from the Athabasca oil sands is too low. (speedypaper.com)
Research1
- North Olympic Peninsula Skills Center Natural Resources To provide a program that provides hands-on, relevant natural resources research experience while meeting the needs of and building capacity within individual students and the North Olympic Peninsula region. (olyopen.com)
Florida3
- Survey report: control technology evaluation for controlling worker exposure to asphalt fumes from roofing kettles: kettle operated using an afterburner system at Tampa Bay Technical High School, and West Park Village at West Chase, Tampa, Florida. (cdc.gov)
- One survey was conducted at Tampa Bay Technical High School in Tampa, Florida where cap sheet was being installed on top of a recently installed built up asphalt roof. (cdc.gov)
- Bay scallops ( Argopecten irradians Lamarck) are ecologically important in U.S. Atlantic waters off northeastern states and in the Florida Gulf of Mexico, and have been intensely harvested from both of those regions for decades. (bioone.org)
Water2
- 2020. Treatment of Polycyclic Aromatic Hydrocarbons in Oil Sands Process Affected Water with a Surface Flow Treatment Wetland . (sfu.ca)
- If you re the largest user of drinking water in an extremely arid region and you re also on the edge of a popular fishing and recreation area, you face a double challenge fresh water restrictions and low tolerance for wastewater emissions. (scienceagogo.com)
Scientists1
- Other scientists studying the trends in the Bay of Bengal say the region has registered 26 per cent increase in severe cyclonic storms in the last 120 years, intensifying post-monsoon. (panossouthasia.org)
Properties1
- Samples were taken from Tiverton roadways, residential properties, and the Bay View Recreation Area. (cdc.gov)
Area2
- Callers should refer to the Bay Street Tiverton Study Area, Tiverton, R.I. (cdc.gov)
- The main crude oil refineries of Alberta are located in Edmonton, an area that is also among the most populated regions of the province. (speedypaper.com)
West3
- The site boundaries are Mount Hope Bay and a petroleum terminal to the west, Church Street to the east, State Avenue to the north, and Lepes Road to the south. (cdc.gov)
- The kettle operator's exposures at the Tampa Bay Technical High School to TP, BSF, and total PAC were all less than the exposures measured for the kettle operator at West Park Village. (cdc.gov)
- For the roof level workers, exposures to TP, BSF, and total PAC were 28%, 10%, and 48% higher for the workers at the Tampa Bay Technical High School when compared to the workers at the West Park Village. (cdc.gov)
Baylike regions1
- Bay or baylike regions of polycyclic aromatic hydrocarbons were potent inhibitors of Gap junctional intercellular communication. (nih.gov)
Compounds1
- Personal breathing zone and area air samples were collected and analyzed for total particulate (TP), benzene soluble fraction (BSF) of the TP, and total polycyclic aromatic compounds (PAC). (cdc.gov)
Oxidative3
- Mixture analysis of associations between occupational exposure to polycyclic aromatic hydrocarbons and sperm oxidative DNA damage. (cdc.gov)
- Bay and bay-like regions of the PAH mixture were the most important group for estimating the associations between the PAH mixture and sperm oxidative stress status. (cdc.gov)
- 25. Involvement of oxidative stress and activation of aryl hydrocarbon receptor in elevation of CYP1A1 expression and activity in lung cells and tissues by arsenic: an in vitro and in vivo study. (nih.gov)
Arsenic2
- Residents living within a 36-acre area of Tiverton, R.I., may have been exposed to arsenic, lead, mercury, and polycyclic aromatic hydrocarbons, says a final public health consultation released today by the Agency for Toxic Substances and Disease Registry (ATSDR). (cdc.gov)
- A report released by the federal Agency for Toxic Substances and Disease Registry (ATSDR) says that residents living within a 36-acre area of Tiverton could have been exposed to soil contaminated with arsenic, lead, mercury, and polycyclic aromatic hydrocarbons in the past and present. (cdc.gov)
Petroleum2
- The site boundaries are Mount Hope Bay and a petroleum terminal to the west, Church Street to the east, State Avenue to the north, and Lepes Road to the south. (cdc.gov)
- AMAP has decided to prepare an assessment of the environmental impacts of oil and gas developments in the Arctic and of pollution by petroleum hydrocarbons. (amap.no)
Benzo3
- 22. Aromatic hydrocarbon receptor (AhR).AhR nuclear translocator- and p53-mediated induction of the murine multidrug resistance mdr1 gene by 3-methylcholanthrene and benzo(a)pyrene in hepatoma cells. (nih.gov)
- 33. Mutagenicity of benzo[a]pyrene bay-region sulfonates. (nih.gov)
- 39. Cellular defense mechanisms against benzo[a]pyrene in testicular Leydig cells: implications of p53, aryl-hydrocarbon receptor, and cytochrome P450 1A1 status. (nih.gov)
Molecular weight1
- A novel grouping approach needed for the hierarchical variable selection process was developed based on PAH bay region and molecular weight. (cdc.gov)
Pyrene1
- The fjord region PAH dibenzo[a,l]pyrene exhibits the highest levels of carcinogenic activity of all PAH as yet tested in rodent tumor models. (psu.edu)
Molecule2
- The benzoazulenes, which play a key role in the planarization of the molecule, resulted from two conjoined bay regions in the reacted molecular precursors. (ehu.eus)
- Another hexacyclic aromatic hydrocarbon, dibenzo[c,p]chrysene (DBC), is a unique PAH that possesses one bay region and two fjord regions within the same molecule. (psu.edu)
Structure1
- Particularly, we demonstrated a new on-surface route to create benzoazulene moieties within the structure of a [18]annulene based polycyclic aromatic hydrocarbon. (ehu.eus)
Coastal2
- In the Azov coastal region from the mid to end of the 20th century, the trend of reduced wind activity persists, both for average annual and seasonal values. (aquadocs.org)
- Apart from cyclones, which predominantly occur in the tropics, all listed pressures can affect all coastal regions of Australia. (dcceew.gov.au)
Activation2
- 29. Cyclooxygenase-2 promoter activation by the aromatic hydrocarbon receptor in breast cancer mcf-7 cells: repressive effects of conjugated linoleic acid. (nih.gov)
- reduction of in cigarette smoke, 95 AROMATIC AMINES binding to nucleic acids, 91 bladder neoplasms and, 94-95 in bladder neoplasm etiology, 41 metabolic activation and carcinogen- icity, 91 AROMATIC HYDROCARBON CON. (nih.gov)
Workers2
- For the roof level workers, exposures to TP, BSF, and total PAC were 28%, 10%, and 48% higher for the workers at the Tampa Bay Technical High School when compared to the workers at the West Park Village. (cdc.gov)
- Exposures were higher for the roof level workers at the Tampa Bay Technical High School. (cdc.gov)
Human1
- 34. Resveratrol prevents epigenetic silencing of BRCA-1 by the aromatic hydrocarbon receptor in human breast cancer cells. (nih.gov)
High5
- Survey report: control technology evaluation for controlling worker exposure to asphalt fumes from roofing kettles: kettle operated using an afterburner system at Tampa Bay Technical High School, and West Park Village at West Chase, Tampa, Florida. (cdc.gov)
- One survey was conducted at Tampa Bay Technical High School in Tampa, Florida where cap sheet was being installed on top of a recently installed built up asphalt roof. (cdc.gov)
- The kettle used at the Tampa Bay Technical High School was equipped with an afterburner system and safety loading door, and all of the asphalt was added through the safety loading door. (cdc.gov)
- The kettle operator's exposures at the Tampa Bay Technical High School to TP, BSF, and total PAC were all less than the exposures measured for the kettle operator at West Park Village. (cdc.gov)
- The Ecuadorian government then paid for McLaughlin to fly to the country in September and participate in a large-scale media campaign and to tour the Lago Agrio region where Texaco - an oil company that Chevron absorbed a dozen years ago - left a legacy of destruction, contamination, and, residents say, high rates of cancer and other illnesses. (eastbayexpress.com)
Affect1
- 30. Dietary flavonols quercetin and kaempferol are ligands of the aryl hydrocarbon receptor that affect CYP1A1 transcription differentially. (nih.gov)
Temperature2
- The highest trend of air temperature increase was observed in the region of the Sea of Azov at the beginning of the 21st century (up to 0.08 °C/year). (aquadocs.org)
- It should be noted that, since 2010, there has been a decrease in temperature growth rate in the Sea of Azov region. (aquadocs.org)
Apply1
- Extreme weather events apply significant pressure to the Australian region. (dcceew.gov.au)
Annual1
- The report comes on the heels of the fifth annual 'healing walk' in the oilsands region, during which Chief Allan Adam of the Athabasca Chipewyan First Nation said the report would "blow the socks off industry and government. (thenarwhal.ca)
Community1
- The obtained data were compared with the average long-term indicators of the zooplankton community in the central part of the Kondopoga Bay at the beginning of July, 1988-1998. (aquadocs.org)