Basic leucine zipper transcription factors. Medical search

DNA-binding motifs formed from two alpha-helixes which intertwine for about eight turns into a coiled coil and then bifurcate to form Y shaped structures. Leucines occurring in heptad repeats end up on the same sides of the helixes and are adjacent to each other in the stem of the Y (the "zipper" region). The DNA-binding residues are located in the bifurcated region of the Y.

A large superfamily of transcription factors that contain a region rich in BASIC AMINO ACID residues followed by a LEUCINE ZIPPER domain.

Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.

A basic-leucine zipper transcription factor that was originally described as a transcriptional regulator controlling expression of the BETA-GLOBIN gene. It may regulate the expression of a wide variety of genes that play a role in protecting cells from oxidative damage.

Abscission-accelerating plant growth substance isolated from young cotton fruit, leaves of sycamore, birch, and other plants, and from potatoes, lemons, avocados, and other fruits.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.

Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.

DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.

A family of transcription factors found primarily in PLANTS that bind to the G-box DNA sequence CACGTG or to a consensus sequence CANNTG.

Maf proto-oncogene protein is the major cellular homolog of the V-MAF ONCOGENE PROTEIN. It was the first of the mammalian MAF TRANSCRIPTION FACTORS identified, and it is induced in activated T-LYMPHOCYTES and regulates GENETIC TRANSCRIPTION of INTERLEUKIN-4. c-maf is frequently translocated to an immunoglobulin locus in MULTIPLE MYELOMA.

A family of transcription factors that contain regions rich in basic residues, LEUCINE ZIPPER domains, and HELIX-LOOP-HELIX MOTIFS.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in plants.

Proteins found in plants (flowers, herbs, shrubs, trees, etc.). The concept does not include proteins found in vegetables for which VEGETABLE PROTEINS is available.

A plant genus of the family BRASSICACEAE that contains ARABIDOPSIS PROTEINS and MADS DOMAIN PROTEINS. The species A. thaliana is used for experiments in classical plant genetics as well as molecular genetic studies in plant physiology, biochemistry, and development.

A basic helix-loop-helix leucine zipper transcription factor that regulates the CELL DIFFERENTIATION and development of a variety of cell types including MELANOCYTES; OSTEOCLASTS; and RETINAL PIGMENT EPITHELIUM. Mutations in MITF protein have been associated with OSTEOPETROSIS and WAARDENBURG SYNDROME.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

A CCAAT-enhancer-binding protein found in LIVER; INTESTINES; LUNG and ADIPOSE TISSUE. It is an important mediator of INTERLEUKIN-6 signaling.

Diffusible gene products that act on homologous or heterologous molecules of viral or cellular DNA to regulate the expression of proteins.

Proteins that originate from plants species belonging to the genus ARABIDOPSIS. The most intensely studied species of Arabidopsis, Arabidopsis thaliana, is commonly used in laboratory experiments.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.

The parts of a macromolecule that directly participate in its specific combination with another molecule.

The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.

The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.

PLANTS, or their progeny, whose GENOME has been altered by GENETIC ENGINEERING.

Nucleotide sequences, usually upstream, which are recognized by specific regulatory transcription factors, thereby causing gene response to various regulatory agents. These elements may be found in both promoter and enhancer regions.

RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.

The encapsulated embryos of flowering plants. They are used as is or for animal feed because of the high content of concentrated nutrients like starches, proteins, and fats. Rapeseed, cottonseed, and sunflower seed are also produced for the oils (fats) they yield.

Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.

Processes that stimulate the GENETIC TRANSCRIPTION of a gene or set of genes.

A family of high molecular weight Maf transcription factors that contain distinct activation domains.

The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.

Recurring supersecondary structures characterized by 20 amino acids folding into two alpha helices connected by a non-helical "loop" segment. They are found in many sequence-specific DNA-BINDING PROTEINS and in CALCIUM-BINDING PROTEINS.

Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.

Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.

A CCAAT-enhancer-binding protein found in LIVER; ADIPOSE TISSUE; INTESTINES; LUNG; ADRENAL GLANDS; PLACENTA; OVARY and peripheral blood mononuclear cells (LEUKOCYTES, MONONUCLEAR). Experiments with knock-out mice have demonstrated that CCAAT-enhancer binding protein-alpha is essential for the functioning and differentiation of HEPATOCYTES and ADIPOCYTES.

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

Established cell cultures that have the potential to propagate indefinitely.

Ubiquitously expressed basic HELIX-LOOP-HELIX MOTIF transcription factors. They bind CANNTG sequences in the promoters of a variety of GENES involved in carbohydrate and lipid metabolism.

A class of proteins that were originally identified by their ability to bind the DNA sequence CCAAT. The typical CCAAT-enhancer binding protein forms dimers and consists of an activation domain, a DNA-binding basic region, and a leucine-rich dimerization domain (LEUCINE ZIPPERS). CCAAT-BINDING FACTOR is structurally distinct type of CCAAT-enhancer binding protein consisting of a trimer of three different subunits.

Proteins which maintain the transcriptional quiescence of specific GENES or OPERONS. Classical repressor proteins are DNA-binding proteins that are normally bound to the OPERATOR REGION of an operon, or the ENHANCER SEQUENCES of a gene until a signal occurs that causes their release.

The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.

Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.

An activating transcription factor that plays a key role in cellular responses to GENOTOXIC STRESS and OXIDATIVE STRESS.

A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).

Activating transcription factors were originally identified as DNA-BINDING PROTEINS that interact with early promoters from ADENOVIRUSES. They are a family of basic leucine zipper transcription factors that bind to the consensus site TGACGTCA of the cyclic AMP response element, and are closely related to CYCLIC AMP-RESPONSIVE DNA-BINDING PROTEIN.

The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.

Cellular DNA-binding proteins encoded by the c-jun genes (GENES, JUN). They are involved in growth-related transcriptional control. There appear to be three distinct functions: dimerization (with c-fos), DNA-binding, and transcriptional activation. Oncogenic transformation can take place by constitutive expression of c-jun.

The process by which two molecules of the same chemical composition form a condensation product or polymer.

An activating transcription factor that regulates the expression of a variety of GENES involved in amino acid metabolism and transport. It also interacts with HTLV-I transactivator protein.

A multiprotein complex composed of the products of c-jun and c-fos proto-oncogenes. These proteins must dimerize in order to bind to the AP-1 recognition site, also known as the TPA-responsive element (TRE). AP-1 controls both basal and inducible transcription of several genes.

Promoter-specific RNA polymerase II transcription factor that binds to the GC box, one of the upstream promoter elements, in mammalian cells. The binding of Sp1 is necessary for the initiation of transcription in the promoters of a variety of cellular and viral GENES.

Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.

The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.

A protein that has been shown to function as a calcium-regulated transcription factor as well as a substrate for depolarization-activated CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES. This protein functions to integrate both calcium and cAMP signals.

An activating transcription factor that regulates expression of a variety of GENES including C-JUN GENES; CYCLIN A; CYCLIN D1; and ACTIVATING TRANSCRIPTION FACTOR 3.

Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)

A transcription factor that controls the expression of variety of proteins including CYTOCHROME C and 5-AMINOLEVULINATE SYNTHETASE. It plays an important role in maintenance of the RESPIRATORY CHAIN of MITOCHONDRIA.

A basic-leucine zipper transcription factor that regulates GLOBIN gene expression and is related to TRANSCRIPTION FACTOR AP-1. NF-E2 consists of a small MAF protein subunit and a tissue-restricted 45 kDa subunit.

A family of DNA-binding transcription factors that contain a basic HELIX-LOOP-HELIX MOTIF.

An electrophoretic technique for assaying the binding of one compound to another. Typically one compound is labeled to follow its mobility during electrophoresis. If the labeled compound is bound by the other compound, then the mobility of the labeled compound through the electrophoretic medium will be retarded.

The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.

The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.

Genes whose expression is easily detectable and therefore used to study promoter activity at many positions in a target genome. In recombinant DNA technology, these genes may be attached to a promoter region of interest.

A small Maf protein involved in differentiation of ERYTHROID CELLS. MafK was originally described as the small subunit of the NF-E2 Transcription Factor, but other small MAF PROTEINS also serve as NF-E2 subunits.

A tissue-specific subunit of NF-E2 transcription factor that interacts with small MAF PROTEINS to regulate gene expression. P45 NF-E2 protein is expressed primarily in MEGAKARYOCYTES; ERYTHROID CELLS; and MAST CELLS.

Proteins encoded by homeobox genes (GENES, HOMEOBOX) that exhibit structural similarity to certain prokaryotic and eukaryotic DNA-binding proteins. Homeodomain proteins are involved in the control of gene expression during morphogenesis and development (GENE EXPRESSION REGULATION, DEVELOPMENTAL).

A family of transcription factors that control expression of a variety of nuclear GENES encoding proteins that function in the RESPIRATORY CHAIN of the MITOCHONDRIA.

Proteins obtained from the species SACCHAROMYCES CEREVISIAE. The function of specific proteins from this organism are the subject of intense scientific interest and have been used to derive basic understanding of the functioning similar proteins in higher eukaryotes.

Proteins found in any species of fungus.

Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.

A subclass of winged helix DNA-binding proteins that share homology with their founding member fork head protein, Drosophila.

A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement.

Enzymes that oxidize certain LUMINESCENT AGENTS to emit light (PHYSICAL LUMINESCENCE). The luciferases from different organisms have evolved differently so have different structures and substrates.

The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.

Proteins prepared by recombinant DNA technology.

A family of DNA binding proteins that regulate expression of a variety of GENES during CELL DIFFERENTIATION and APOPTOSIS. Family members contain a highly conserved carboxy-terminal basic HELIX-TURN-HELIX MOTIF involved in dimerization and sequence-specific DNA binding.

Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.

Motifs in DNA- and RNA-binding proteins whose amino acids are folded into a single structural unit around a zinc atom. In the classic zinc finger, one zinc atom is bound to two cysteines and two histidines. In between the cysteines and histidines are 12 residues which form a DNA binding fingertip. By variations in the composition of the sequences in the fingertip and the number and spacing of tandem repeats of the motif, zinc fingers can form a large number of different sequence specific binding sites.

A technique for identifying specific DNA sequences that are bound, in vivo, to proteins of interest. It involves formaldehyde fixation of CHROMATIN to crosslink the DNA-BINDING PROTEINS to the DNA. After shearing the DNA into small fragments, specific DNA-protein complexes are isolated by immunoprecipitation with protein-specific ANTIBODIES. Then, the DNA isolated from the complex can be identified by PCR amplification and sequencing.

The functional hereditary units of PLANTS.

Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.

Screening techniques first developed in yeast to identify genes encoding interacting proteins. Variations are used to evaluate interplay between proteins and other molecules. Two-hybrid techniques refer to analysis for protein-protein interactions, one-hybrid for DNA-protein interactions, three-hybrid interactions for RNA-protein interactions or ligand-based interactions. Reverse n-hybrid techniques refer to analysis for mutations or other small molecules that dissociate known interactions.

A family of zinc finger transcription factors that share homology with Kruppel protein, Drosophila. They contain a highly conserved seven amino acid spacer sequence in between their ZINC FINGER MOTIFS.

The so-called general transcription factors that bind to RNA POLYMERASE II and that are required to initiate transcription. They include TFIIA; TFIIB; TFIID; TFIIE; TFIIF; TFIIH; TFII-I; and TFIIJ. In vivo they apparently bind in an ordered multi-step process and/or may form a large preinitiation complex called RNA polymerase II holoenzyme.

A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.

Annual cereal grass of the family POACEAE and its edible starchy grain, rice, which is the staple food of roughly one-half of the world's population.

The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.

Any of the processes by which cytoplasmic factors influence the differential control of gene action in viruses.

Cis-acting DNA sequences which can increase transcription of genes. Enhancers can usually function in either orientation and at various distances from a promoter.

Nucleic acid sequences involved in regulating the expression of genes.

A ubiquitously expressed zinc finger-containing protein that acts both as a repressor and activator of transcription. It interacts with key regulatory proteins such as TATA-BINDING PROTEIN; TFIIB; and ADENOVIRUS E1A PROTEINS.

A signal transducer and activator of transcription that mediates cellular responses to INTERLEUKIN-6 family members. STAT3 is constitutively activated in a variety of TUMORS and is a major downstream transducer for the CYTOKINE RECEPTOR GP130.

A GATA transcription factor that is expressed in the MYOCARDIUM of developing heart and has been implicated in the differentiation of CARDIAC MYOCYTES. GATA4 is activated by PHOSPHORYLATION and regulates transcription of cardiac-specific genes.

Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.

The major sequence-specific DNA-binding component involved in the activation of transcription of RNA POLYMERASE II. It was originally described as a complex of TATA-BOX BINDING PROTEIN and TATA-BINDING PROTEIN ASSOCIATED FACTORS. It is now know that TATA BOX BINDING PROTEIN-LIKE PROTEINS may take the place of TATA-box binding protein in the complex.

Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3. (1/1416)

The NF-E2-binding sites or Maf recognition elements (MARE) are essential cis-acting elements in the regulatory regions of erythroid-specific genes recognized by the erythroid transcription factor NF-E2, composed of p45 and MafK. Recently, two p45-related factors Nrf1 and Nrf2 were isolated, and they are now collectively grouped as the Cap'n' collar (CNC) family. CNC factors bind to MARE through heterodimer formation with small Maf proteins. We report here the identification and characterization of a novel CNC factor, Nrf3, encoding a predicted 73-kDa protein with a basic region-leucine zipper domain highly homologous to those of other CNC proteins. In vitro and in vivo analyses showed that Nrf3 can heterodimerize with MafK and that this complex binds to the MARE in the chicken beta-globin enhancer and can activate transcription. Nrf3 mRNA is highly expressed in human placenta and B cell and monocyte lineage. Chromosomal localization of human Nrf3 is 7p14-15, which lies near the hoxA gene locus. As the genetic loci of p45, nrf1, and nrf2 have been mapped close to those of hoxC, hoxB, and hoxD, respectively, the present study strongly argues for the idea that a single ancestral gene for the CNC family members may have been localized near the ancestral Hox cluster and have diverged to give rise to four closely related CNC factors through chromosome duplication. (+info)

Silencing of the Epstein-Barr virus latent membrane protein 1 gene by the Max-Mad1-mSin3A modulator of chromatin structure. (2/1416)

The tumor-associated latent membrane protein 1 (LMP1) gene in the Epstein-Barr virus (EBV) genome is activated by EBV-encoded proteins and cellular factors that are part of general signal transduction pathways. As previously demonstrated, the proximal region of the LMP1 promoter regulatory sequence (LRS) contains a negative cis element with a major role in EBNA2-mediated regulation of LMP1 gene expression in B cells. Here, we show that this silencing activity overlaps with a transcriptional enhancer in an LRS sequence that contains an E-box-homologous motif. Mutation of the putative repressor binding site relieved the repression both in a promoter-proximal context and in a complete LRS context, indicating a functional role of the repressor. Gel retardation assays showed that members of the basic helix-loop-helix transcription factor family, including Max, Mad1, USF, E12, and E47, and the corepressor mSin3A bound to the E-box-containing sequence. The enhancer activity correlated with the binding of USF. Moreover, the activity of the LMP1 promoter in reporter constructs was upregulated by overexpression of USF1 and USF2a, and the transactivation was inhibited by the concurrent expression of Max and Mad1. This suggests that Max-Mad1-mediated anchorage of a multiprotein complex including mSin3A and histone deacetylases to the E-box site constitutes the basis for the repression. Removal of acetyl moieties from histones H3 and H4 should result in a chromatin structure that is inaccessible to transcription factors. Accordingly, inhibition of deacetylase activity with trichostatin A induced expression of the endogenous LMP1 gene in EBV-transformed cells. (+info)

Transcriptional repression of human hepatitis B virus genes by a bZIP family member, E4BP4. (3/1416)

Box alpha is an essential element of both the upstream regulatory sequence of the core promoter and the second enhancer, which positively regulate the transcription of human hepatitis B virus (HBV) genes. In this paper, we describe the cloning and characterization of a box alpha binding protein, E4BP4. E4BP4 is a bZIP type of transcription factor. Overexpression of E4BP4 represses the stimulating activity of box alpha in the upstream regulatory sequence of the core promoter and the second enhancer in differentiated human hepatoma cell lines. E4BP4 can also suppress the transcription of HBV genes and the production of HBV virions in a transient-transfection system that mimics the viral infection in vivo. Expression of an E4BP4 antisense transcript can, instead, elevate the transcription of the core promoter. A low abundance of E4BP4 protein and mRNA in differentiated human hepatoma cell lines is detected, and E4BP4 is not a major component of box alpha binding proteins in untransfected differentiated human hepatoma cell lines. C/EBPalpha and C/EBPbeta, in contrast, are major components of the box alpha binding activity present in nuclear extracts. E4BP4 has a stronger binding affinity towards box alpha than the endogenous box alpha binding activity present in nuclear extracts. Structure and function analysis of E4BP4 reveals that DNA binding activity is sufficient to confer the negative regulatory function of E4BP4. These results indicate that binding site occlusion is the mechanism whereby E4BP4 suppresses transcription in HBV. (+info)

Two distinct interleukin-3-mediated signal pathways, Ras-NFIL3 (E4BP4) and Bcl-xL, regulate the survival of murine pro-B lymphocytes. (4/1416)

Hematopoietic cells require cytokine-initiated signals for survival as well as proliferation. The pathways that transduce these signals, ensuring timely regulation of cell fate genes, remain largely undefined. The NFIL3 (E4BP4) transcription factor, Bcl-xL, and constitutively active mutants of components in Ras signal transduction pathways have been identified as key regulation proteins affecting murine interleukin-3 (IL-3)-dependent cell survival. Here we show that expression of NFIL3 is regulated by oncogenic Ras mutants through both the Raf-mitogen-activated protein kinase and phosphatidylinositol 3-kinase pathways. NFIL3 inhibits apoptosis without affecting Bcl-xL expression. By contrast, Bcl-xL levels are regulated through the membrane proximal portion in the cytoplasmic domain of the receptor (betac chain), which is shared by IL-3 and granulocyte-macrophage colony-stimulating factor. Activation of either pathway alone is insufficient to ensure cell survival, indicating that multiple independent signal transduction pathways mediate the survival of developing B-lymphoid cells. (+info)

Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) encodes a homologue of the Epstein-Barr virus bZip protein EB1. (5/1416)

Analysis of the recently completed genomic sequence of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) revealed that ORF 50 encodes a protein with homology to the Epstein-Barr virus (EBV) transcription factor R. In this report, we show that ORF K8, contiguous to ORF 50, is interrupted by two introns and that the spliced RNA is translated into a bZip protein that has homology to the EBV transcription factor EB1. The newly characterized K8 protein forms homodimers but does not heterodimerize with other members of the bZip protein family. (+info)

Multiple regulatory elements control the expression of the yeast ACR1 gene. (6/1416)

The ACR1 gene, encoding a succinate-fumarate transporter, is required by the yeast Saccharomyces cerevisiae for ethanol utilization. Accordingly, gene expression is induced by ethanol and repressed by glucose. Here, we investigated three carbon source response elements present in its promoter region. Specific deletions as well as functional analysis of the elements in a heterologous promoter confirmed their role in transcriptional regulation. Protein binding to carbon source response elements of the ICL1 promoter was competed by all three elements to various extents by the respective ACR1 sequences. In addition, two putative stress response promoter elements present in the ACR1 promoter were investigated in deletion analyses and shown to contribute to gene expression. (+info)

A novel human DNA-binding protein with sequence similarity to a subfamily of redox proteins which is able to repress RNA-polymerase-III-driven transcription of the Alu-family retroposons in vitro. (7/1416)

In this study we identified a novel protein which may contribute to the transcriptional inactivity of Alu retroposons in vivo. A human cDNA clone encoding this protein (ACR1) was isolated from a human expression library using South-western screening with an Alu subfragment, implicated in the regulation of Alu in vitro transcription and interacting with a HeLa nuclear protein down-regulated in adenovirus-infected cells. Bacterially expressed ACR1 is demonstrated to inhibit RNA polymerase III (Pol III)-dependent Alu transcription in vitro but showed no repression of transcription of a tRNA gene or of a reporter gene under control of a Pol II promoter. ACR1 mRNA is also found to be down-regulated in adenovirus-infected HeLa cells, consistent with a possible repressor function of the protein in vivo. ACR1 is mainly (but not exclusively) located in cytoplasm and appears to be a member of a weakly characterized redox protein family having a central, highly conserved sequence motif, PGAFTPXCXXXXLP. One member of the family identified earlier as peroxisomal membrane protein (PMP)20 is known to interact in a sequence-specific manner with a yeast homolog of mammalian cyclosporin-A-binding protein cyclophilin, and mammalian cyclophilin A (an abundant ubiquitously expressed protein) is known to interact with human transcriptional repressor YY1, which is a major sequence-specific Alu-binding protein in human cells. It appears, therefore, that transcriptional silencing of Alu in vivo is a result of complex interactions of many proteins which bind to its Pol III promoter. (+info)

Ubiquitination and degradation of ATF2 are dimerization dependent. (8/1416)

Ubiquitination and proteasome-dependent degradation are key determinants of the half-lives of many transcription factors. Homo- or heterodimerization of basic region-leucine zipper (bZIP) transcription factors is required for their transcriptional activities. Here we show that activating transcription factor 2 (ATF2) heterodimerization with specific bZIP proteins is an important determinant of the ubiquitination and proteasome-dependent degradation of ATF2. Depletion of c-Jun as one of the ATF2 heterodimer partners from the targeting proteins decreased the efficiency of ATF2 ubiquitination in vitro, whereas the addition of exogenously purified c-Jun restored it. Similarly, overexpression of c-Jun in 293T human embryo kidney cells increased ATF2 ubiquitination in vivo and reduced its half-life in a dose-dependent manner. Mutations of ATF2 that disrupt its dimerization inhibited ATF2 ubiquitination in vitro and in vivo. Conversely, removal of residues 150 to 248, as in a constitutively active ATF2 spliced form, enhanced ATF2 dimerization and transactivation, which coincided with increased ubiquitination and decreased stability. Our findings indicate the increased sensitivity of transcriptionally active dimers of ATF2 to ubiquitination and proteasome-dependent degradation. Based on these observations, we conclude that increased targeting of a transcriptionally active ATF2 form indicates the mechanism by which the magnitude and the duration of the cellular stress response are regulated. (+info)

... are, as their name indicates, transcription factors containing both ... Basic+helix-loop-helix+leucine+zipper+transcription+factors at the US National Library of Medicine Medical Subject Headings ( ... Basic helix-loop-helix and leucine zipper motifs. Examples include Microphthalmia-associated transcription factor and Sterol ... Transcription factors, All stub articles, Genetics stubs). ...

https://en.wikipedia.org/wiki/Basic_helix-loop-helix_leucine_zipper_transcription_factors

ATF6 (activating transcription factor 6) is a basic leucine zipper transcription factor. Upon Grp78 dissociation, the entire ... Involvement of basic leucine zipper transcription factors". The Journal of Biological Chemistry. 273 (50): 33741-9. doi:10.1074 ... is upregulated downstream of the bZIP transcription factor ATF4 (activating transcription factor 4) and uniquely responsive to ... The activated transcription factor upregulates UPR 'stress genes' by directly binding to stress element promoters in the ...

https://en.wikipedia.org/wiki/Unfolded_protein_response

Involvement of basic leucine zipper transcription factors". The Journal of Biological Chemistry. 273 (50): 33741-9. doi:10.1074 ... "Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins". ... MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor ...

https://en.wikipedia.org/wiki/CHMP1A

... leucine zipper transcription factors PDB: 1x0o; Card PB, Erbel PJ, Gardner KH (October 2005). " ... The word "basic" does not refer to complexity but to the chemistry of the motif because transcription factors in general ... In general, transcription factors (including this type) are dimeric, each with one helix containing basic amino acid residues ... PDOC00038 in PROSITE Basic+Helix-Loop-Helix+Transcription+Factors at the US National Library of Medicine Medical Subject ...

https://en.wikipedia.org/wiki/Basic_helix–loop–helix

This gene encodes a basic leucine zipper (bZIP) transcription factor. The gene is located on the long arm of chromosome 20 ( ... This condition is caused by mutations in the transcription factor MafB, or V-maf musculoaponeurotic fibrosarcoma oncogene ...

https://en.wikipedia.org/wiki/Multicentric_carpotarsal_osteolysis_syndrome

Basic leucine zipper transcription factor, ATF-like, also known as BATF, is a protein which in humans is encoded by the BATF ... "Entrez Gene: BATF basic leucine zipper transcription factor, ATF-like". Schraml BU, Hildner K, Ise W, Lee WL, Smith WA, Solomon ... protein that belongs to the AP-1/ATF superfamily of transcription factors. The leucine zipper of this protein mediates ... The protein encoded by this gene is a nuclear basic leucine zipper (bZIP) ...

https://en.wikipedia.org/wiki/BATF_(gene)

Basic leucine zipper transcription factor, ATF-like 2 is a protein that, in humans, is encoded by the BATF2 gene. "Entrez Gene ... Basic leucine zipper transcription factor, ATF-like 2". Retrieved 2014-07-06. Ma, H; Liang, X; Chen, Y; Pan, K; Sun, J; Wang, H ... Huang, Q; Yang, Y; Li, X; Huang, S (2011). "Transcription suppression of SARI (suppressor of AP-1, regulated by IFN) by BCR-ABL ...

https://en.wikipedia.org/wiki/BATF2

... basic-leucine zipper (bZIP) transcription factor. Several isoforms of NFE2L1 have been described for both human and mouse genes ... Kwong M, Kan YW, Chan JY (Dec 1999). "The CNC basic leucine zipper factor, Nrf1, is essential for cell survival in response to ... "The Fbw7 tumor suppressor regulates nuclear factor E2-related factor 1 transcription factor turnover through proteasome- ... Oh DH, Rigas D, Cho A, Chan JY (Nov 2012). "Deficiency in the nuclear-related factor erythroid 2 transcription factor (Nrf1) ...

https://en.wikipedia.org/wiki/NFE2L1

It has a basic leucine zipper domain, a characteristic of many transcription factors. ZEBRA binds to the oriLyt (lytic origin ... Schepers, A.; Pich, D.; Hammerschmidt, W.(1993). Transcription factor with homology to the AP-1 family links RNA transcription ... 2009). Epstein-Barr virus polymerase processivity factor enhances BALF2 promoter transcription as a coactivator for the BZLF1 ... It interacts with the viral helicase-primase complex and BMRF1, the viral polymerase accessory factor. It has been shown to ...

https://en.wikipedia.org/wiki/BZLF1

C/EBPs, transcription factors, are members of the basic-leucine zipper class. cAMP, an inducer of adipogenesis, can promote ... Therefore, transcription factors are crucial for adipogenesis. Transcription factors, peroxis proliferator-activated receptor γ ... other transcription factors function in the progression of differentiation. Adipocyte determination and differentiation factor ... The second phase of growth arrest is the expression of two key transcription factors PPARγ and C/EBPα which promote expression ...

https://en.wikipedia.org/wiki/Adipogenesis

This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family ( ... "Entrez Gene: BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1". Ozono R (Apr 2006). "New ... belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription ... of the mouse Bach1 gene encoding a BTB-basic leucine zipper transcription factor and its mapping to chromosome 21q22.1". ...

https://en.wikipedia.org/wiki/BACH1

MafB is a basic leucine zipper (bZIP) transcription factor that plays an important role in the regulation of lineage-specific ... "The mouse segmentation gene kr encodes a novel basic domain-leucine zipper transcription factor". Cell. 79 (6): 1025-34. doi: ... "The mouse segmentation gene kr encodes a novel basic domain-leucine zipper transcription factor". Cell. 79 (6): 1025-34. doi: ... Transcription factor MafB also known as V-maf musculoaponeurotic fibrosarcoma oncogene homolog B is a protein that in humans is ...

https://en.wikipedia.org/wiki/MAFB_(gene)

SREBPs belong to the basic-helix-loop-helix leucine zipper class of transcription factors. Unactivated SREBPs are attached to ... a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene". Cell ... Gasic GP (Apr 1994). "Basic-helix-loop-helix transcription factor and sterol sensor in a single membrane-bound molecule". Cell ... Wang X, Sato R, Brown MS, Hua X, Goldstein JL (Apr 1994). "SREBP-1, a membrane-bound transcription factor released by sterol- ...

https://en.wikipedia.org/wiki/Sterol_regulatory_element-binding_protein

"Entrez Gene: BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2". Rosbrook GO, Stead MA, Carr SB, Wright ... belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription ... "A combinatorial code for gene expression generated by transcription factor Bach2 and MAZR (MAZ-related factor) through the BTB/ ... In T cells, BACH2 is recruited by the transcription factor Vitamin D receptor (VDR) both in vitro and in vivo (for example, in ...

https://en.wikipedia.org/wiki/BACH2

This gene encodes a basic motif-leucine zipper transcription factor of the Maf subfamily. The encoded protein is conserved ... "The minimal transactivation domain of the basic motif-leucine zipper transcription factor NRL interacts with TATA-binding ... "A conserved retina-specific gene encodes a basic motif/leucine zipper domain". Proceedings of the National Academy of Sciences ... Neural retina-specific leucine zipper protein is a protein that in humans is encoded by the NRL gene. ...

https://en.wikipedia.org/wiki/NRL_(gene)

As a chaperone, ALY promotes dimerization of transcription factors containing basic leucine zipper (bZIP) domains., thereby ... The ALYREF gene encodes Aly/REF export factor (ALY; THO complex subunit 4, Tho4; RNA and export factor binding protein 1, ... Aly/REF export factor, also known as THO complex subunit 4 is a protein that in humans is encoded by the ALYREF gene. ... The TRanscription-EXport (TREX) complex, a key player in mRNA export, includes the THO subcomplex, the RNA helicase UAP56, and ...

https://en.wikipedia.org/wiki/ALYREF

Leucine zippers are a dimerization motif of the bZIP (Basic-region leucine zipper) class of eukaryotic transcription factors. ... "Genomic survey and gene expression analysis of the basic leucine zipper transcription factor family in rice". Plant Physiology ... Leucine zipper regulatory proteins include c-fos and c-jun (the AP1 transcription factor), important regulators of normal ... Nantel A, Quatrano RS (December 1996). "Characterization of three rice basic/leucine zipper factors, including two inhibitors ...

https://en.wikipedia.org/wiki/Leucine_zipper

NRF2 is a basic leucine zipper (bZip) transcription factor with a Cap "n" Collar (CNC) structure. NRF2 possesses seven highly ... NFE2L2 and other genes, such as NFE2, NFE2L1 and NFE2L3, encode basic leucine zipper (bZIP) transcription factors. They share ... is a transcription factor that in humans is encoded by the NFE2L2 gene. NRF2 is a basic leucine zipper (bZIP) protein that may ... Moi P, Chan K, Asunis I, Cao A, Kan YW (October 1994). "Isolation of NF-E2-related factor 2 (NRF2), a NF-E2-like basic leucine ...

https://en.wikipedia.org/wiki/NFE2L2

The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These ... a gene at 17q21.1 encoding a putative basic helix-loop-helix leucine-zipper transcription factor". Gene. 181 (1-2): 7-11. doi: ... Billin AN, Eilers AL, Coulter KL, Logan JS, Ayer DE (December 2000). "MondoA, a novel basic helix-loop-helix-leucine zipper ... Song Z, Yang H, Zhou L, Yang F (2019). "Glucose-Sensing Transcription Factor MondoA/ChREBP as Targets for Type 2 Diabetes: ...

https://en.wikipedia.org/wiki/MLX_(gene)

This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc / Max / Mad superfamily. This protein ... Song Z, Yang H, Zhou L, Yang F (October 2019). "Glucose-Sensing Transcription Factor MondoA/ChREBP as Targets for Type 2 ... de Luis O, Valero MC, Jurado LA (March 2000). "WBSCR14, a putative transcription factor gene deleted in Williams-Beuren ... is a new member of the Mlx transcription factor network". Human Molecular Genetics. 10 (6): 617-627. doi:10.1093/hmg/10.6.617. ...

https://en.wikipedia.org/wiki/Carbohydrate-responsive_element-binding_protein

The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. SREBP-1a regulates ... a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene". Cell ... a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element ... Wang X, Sato R, Brown MS, Hua X, Goldstein JL (Apr 1994). "SREBP-1, a membrane-bound transcription factor released by sterol- ...

https://en.wikipedia.org/wiki/Sterol_regulatory_element-binding_protein_1

MITF is a basic helix-loop-helix leucine zipper transcription factor involved in lineage-specific pathway regulation of many ... MITF, TFE3 and TFEB are part of the basic helix-loop-helix-leucine zipper family of transcription factors. Each protein encoded ... "The microphthalmia transcription factor and the related helix-loop-helix zipper factors TFE-3 and TFE-C collaborate to activate ... Microphthalmia-associated transcription factor also known as class E basic helix-loop-helix protein 32 or bHLHe32 is a protein ...

https://en.wikipedia.org/wiki/Microphthalmia-associated_transcription_factor

"Structural basis for DNA recognition by the basic region leucine zipper transcription factor CCAAT/enhancer-binding protein ... This domain is involved in dimerization and DNA binding, as are other transcription factors of the leucine zipper domain- ... They are characterized by a highly conserved basic-leucine zipper (bZIP) domain at the C-terminus. ... CCAAT-enhancer-binding proteins (or C/EBPs) is a family of transcription factors composed of six members, named from C/EBPα to ...

https://en.wikipedia.org/wiki/CCAAT-enhancer-binding_proteins

Involvement of basic leucine zipper transcription factors". J. Biol. Chem. 273 (50): 33741-9. doi:10.1074/jbc.273.50.33741. ... Hai TW, Liu F, Coukos WJ, Green MR (1990). "Transcription factor ATF cDNA clones: an extensive family of leucine zipper ... "Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding ... Activating transcription factor ATF6 has been shown to interact with YY1 and Serum response factor. GRCh38: Ensembl release 89 ...

https://en.wikipedia.org/wiki/ATF6

"The basic region and leucine zipper transcription factor MafK is a new nerve growth factor-responsive immediate early gene that ... MafK is one of the small Maf proteins, which are basic region and leucine zipper (bZIP)-type transcription factors. The HUGO ... belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription ... belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription ...

https://en.wikipedia.org/wiki/MAFK

"A Basic Leucine Zipper Transcription Factor, G-box-binding Factor 1, Regulates Blue Light-mediated Photomorphogenic Growth in ... They have also been successful in demonstrating the correlation between Z-box binding factors and other transcription factors ... The team led by him was successful in synthesizing Z-box binding transcription factors such as ZBF1, ZBF2 and ZBF3 and ... Mallappa, Chandrashekara; Singh, Aparna; Ram, Hathi; Chattopadhyay, Sudip (19 December 2008). "GBF1, a Transcription Factor of ...

https://en.wikipedia.org/wiki/Sudip_Chattopadhyay

... is one of the small Maf proteins, which are basic region and leucine zipper (bZIP)-type transcription factors. The HUGO ... belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription ... Transcription factor MafG is a bZip Maf transcription factor protein that in humans is encoded by the MAFG gene. ... MafG has a bZIP structure that consists of a basic region for DNA binding and a leucine zipper structure for dimer formation. ...

https://en.wikipedia.org/wiki/MAFG

MafF is one of the small Maf proteins, which are basic region and leucine zipper (bZIP)-type transcription factors. The HUGO ... belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription ... Transcription factor MafF is a bZip Maf transcription factor protein that in humans is encoded by the MAFF gene. ... MafF has a bZIP structure that consists of a basic region for DNA binding and a leucine zipper structure for dimer formation. ...

https://en.wikipedia.org/wiki/MAFF_(gene)

DBP is a member of the PAR bZIP (Proline and Acidic amino acid-Rich basic leucine ZIPper) transcription factor family. DBP ... and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGF)". Genomics. 13 (2 ... and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGF)". Genomics. 13 (2 ... "Synergy between transcription factors DBP and C/EBP compensates for a haemophilia B Leyden factor IX mutation". Nature Genetics ...

https://en.wikipedia.org/wiki/DBP_(gene)

Erythroid transcription factor NF-E2 is a haematopoietic-specific basic-leucine zipper protein. Nature 1993; 362:722-8. Fleming ... and the position of Dean for Basic Sciences and Graduate Studies at Harvard Medical School. In 2007, Andrews left to take a ... in Academic Pediatrics 2000 American Federation for Medical Research Foundation Outstanding Investigator Award in Basic Science ...

https://en.wikipedia.org/wiki/Nancy_Andrews_(biologist)

cDNA has also been analyzed using pIII via a two complementary leucine zippers system, Direct Interaction Rescue or by adding ... Gommans WM, Haisma HJ, Rots MG (December 2005). "Engineering zinc finger protein transcription factors: the therapeutic ... Ledsgaard L, Kilstrup M, Karatt-Vellatt A, McCafferty J, Laustsen AH (2018). "Basics of antibody phage display technology" (PDF ... Malik P, Terry TD, Bellintani F, Perham RN (October 1998). "Factors limiting display of foreign peptides on the major coat ...

https://en.wikipedia.org/wiki/Phage_display

... proto-oncogene, bHLH transcription factor is a protein that in humans is encoded by the MYC gene which is a member of the ... Dang CV, McGuire M, Buckmire M, Lee WM (February 1989). "Involvement of the 'leucine zipper' region in the oligomerization and ... myc family of transcription factors. The protein contains basic helix-loop-helix (bHLH) structural motif. This gene is a proto- ... The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA ...

https://en.wikipedia.org/wiki/MYC

... is assembled through the dimerization of a characteristic bZIP domain (basic region leucine zipper) ... A typical bZIP domain consists of a "leucine zipper" region, and a "basic region". The leucine zipper is responsible for ... Apart from the "leucine zipper" and the "basic region" which are important for dimerization and DNA-binding, the c-jun protein ... The basic region of the bZIP domain is just upstream to the leucine zipper, and contains positively charged residues. This ...

https://en.wikipedia.org/wiki/AP-1_transcription_factor

The C/EBPs follow a general basic-leucine zipper (bZIP) domain at the C-terminus and are able to form dimers with other C/EBPs ... It is essential to the transcription that these core binding factors (also referred to as nuclear factor Y or NF-Y) are able to ... from the initial transcription site or a eukaryote gene in which a complex of general transcription factors bind with RNA ... This box along with the GC box is known for binding general transcription factors. Both of these consensus sequences belong to ...

https://en.wikipedia.org/wiki/CAAT_box

The p53 protein is a tumor-suppressing transcription factor (TF), which can recognize when there is an alteration in a cell's ... Conserved domains among human, mouse, and rat homologs include the leucine zipper (LZ) domain at the C-terminal region, two ... It has a small stretch of amino acids in positions 66-75, which are highly basic, and likely are a place of nuclear and ... It has been seen that in some contexts, mda-7 activates STAT transcription factors. However, the STAT pathway is not always ...

https://en.wikipedia.org/wiki/Anticancer_gene

The basic leucine zipper (bZIP) domain is found mainly in eukaryotes and to a limited extent in bacteria. The bZIP domain ... DBD database of predicted transcription factors Kummerfeld SK, Teichmann SA (January 2006). "DBD: a transcription factor ... For example, proteins that regulate transcription by binding DNA are called transcription factors. The final output of most ... the leucines can interact as the teeth in a zipper, allowing dimerization of two proteins. When binding to the DNA, basic amino ...

https://en.wikipedia.org/wiki/DNA-binding_domain

... gene encodes a member of the basic helix-loop-helix leucine zipper family and can function as a cellular transcription factor. ... Gregor PD, Sawadogo M, Roeder RG (Oct 1990). "The adenovirus major late transcription factor USF is a member of the helix-loop- ... "Entrez Gene: USF1 upstream transcription factor 1". Laurila PP, Soronen J, Kooijman S, Forsström S, Boon MR, Surakka I, et al ... Lee JC, Lusis AJ, Pajukanta P (Apr 2006). "Familial combined hyperlipidemia: upstream transcription factor 1 and beyond". ...

https://en.wikipedia.org/wiki/USF1

... protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no ... Gupta K, Anand G, Yin X, Grove L, Prochownik EV (March 1998). "Mmip1: a novel leucine zipper protein that reverses the ... "Differential interactions of Id proteins with basic-helix-loop-helix transcription factors". The Journal of Biological ... "Differential interactions of Id proteins with basic-helix-loop-helix transcription factors". The Journal of Biological ...

https://en.wikipedia.org/wiki/ID1

This protein is a CREB transcription factor that is a member of the leucine zipper family of DNA-binding proteins. This protein ... Takemori H, Kajimura J, Okamoto M (Jul 2007). "TORC-SIK cascade regulates CREB activity through the basic leucine zipper domain ... Don J, Stelzer G (Feb 2002). "The expanding family of CREB/CREM transcription factors that are involved with spermatogenesis". ... Pandey SC (Oct 2004). "The gene transcription factor cyclic AMP-responsive element binding protein: role in positive and ...

https://en.wikipedia.org/wiki/CREB1

"Entrez Gene: MXI1 MAX interactor 1". Gupta K, Anand G, Yin X, Grove L, Prochownik EV (Mar 1998). "Mmip1: a novel leucine zipper ... Wechsler DS, Hawkins AL, Li X, Jabs EW, Griffin CA, Dang CV (Nov 1994). "Localization of the human Mxi1 transcription factor ... This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that ... Gupta K, Anand G, Yin X, Grove L, Prochownik EV (1998). "Mmip1: a novel leucine zipper protein that reverses the suppressive ...

https://en.wikipedia.org/wiki/MXI1

Nuclear factor erythroid 2-related factor 2) transcription factor. NFE2L2 (or NRF2) is a basic leucine zipper (bZIP) protein ...

https://en.wikipedia.org/wiki/Monomethyl_fumarate

... a transcription factor, is a member of the PAR (proline and acidic amino acid-rich) subfamily of basic region/leucine zipper ( ... Essential Initiation Factors Binds to the Activation Domain of PAR Leucine Zipper Transcription Factor Thyroid Embryonic Factor ... 1996). "The proto-oncogene HLF and the related basic leucine zipper protein TEF display highly similar DNA-binding and ... "Entrez Gene: TEF thyrotrophic embryonic factor". Drolet DW, Scully KM, Simmons DM, et al. (1991). "TEF, a transcription factor ...

https://en.wikipedia.org/wiki/TEF_(gene)

C/EBP proteins are known to have a conserved C-terminal structure, basic leucine zipper domain(bZIP), that is necessary for the ... eukaryotic initiation factor 2α (eIF2α), and induction of a transcription factor, activation transcription factor 4 (ATF4), ... As a transcription factor, CHOP can regulate the expression of many anti-apoptotic and pro-apoptotic genes, including genes ... Yang Y, Liu L, Naik I, Braunstein Z, Zhong J, Ren B (2017). "Transcription Factor C/EBP Homologous Protein in Health and ...

https://en.wikipedia.org/wiki/DNA_damage-inducible_transcript_3

Basic Domains 1.1 Class: Leucine zipper factors (bZIP) 1.1.1 Family: AP-1(-like) components; includes (c-Fos/c-Jun) 1.1.2 ... This is also true with transcription factors: Not only do transcription factors control the rates of transcription to regulate ... DNA within nucleosomes is inaccessible to many transcription factors. Some transcription factors, so-called pioneer factors are ... an important class of transcription factors called general transcription factors (GTFs) are necessary for transcription to ...

https://en.wikipedia.org/wiki/Transcription_factor

Oct 1993). "SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein ... Wang X, Sato R, Brown MS, Hua X, Goldstein JL (Apr 1994). "SREBP-1, a membrane-bound transcription factor released by sterol- ... regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor". Cell. 89 (3): 331-40. doi: ... "1985 Basic Medical Research Award". The Lasker Foundation. 2007-09-16. Archived from the original on 2015-09-13. Retrieved 2015 ...

https://en.wikipedia.org/wiki/Michael_Stuart_Brown

The molecular mechanisms governing this function are not yet known, but a basic zipper transcription factor called ATF4 is a ... Following leucine-deprivation in mammals, GCN2 decreases the expression of lipogenic genes via SREBP-1c. SREBP-1c actions upon ... It acts as a transcription factor and activates several genes required for amino acid synthesis. Recently GCN2 has also been ... Eukaryotic initiation factors The three subunits of eIF2: α - EIF2S1 β - EIF2S2 γ - EIF2S3 Kinases of eIF2 HRI (Heme-regulated ...

https://en.wikipedia.org/wiki/Gcn2

... of mutations prevent CCAAT/enhancer-binding protein alpha DNA binding by altering its COOH-terminal basic leucine zipper domain ... and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGF)". Genomics. 13 (2 ... The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain promoters ... It can also form heterodimers with the related proteins CEBP-beta and CEBP-gamma, as well as distinct transcription factors ...

https://en.wikipedia.org/wiki/CEBPA

activator A type of transcription factor that increases the transcription of a gene or set of genes. Most activators work by ... leucine zipper ligase A class of enzymes which catalyze the joining of large molecules such as nucleic acids by forming one or ... basic local alignment search tool (BLAST) A computer algorithm widely used in bioinformatics for aligning and comparing primary ... and not on any transcription factors or other regulatory elements which might promote or inhibit its transcription. contig A ...

https://en.wikipedia.org/wiki/Glossary_of_genetics_(0–L)

... a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element ... transcription factors that are a part of the Signal Transducer And Activator Of Transcription (STAT) family. There is also ... It is hypothesized that this effect occurs through the transcription factor SREBP-1, where the association of insulin and SREBP ... "Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes ...

https://en.wikipedia.org/wiki/Lipogenesis

"The microphthalmia transcription factor and the related helix-loop-helix zipper factors TFE-3 and TFE-C collaborate to activate ... Beckmann H, Kadesch T (1991). "The leucine zipper of TFE3 dictates helix-loop-helix dimerization specificity". Genes Dev. 5 (6 ... Zhao GQ, Zhao Q, Zhou X, Mattei MG, de Crombrugghe B (1993). "TFEC, a basic helix-loop-helix protein, forms heterodimers with ... "Synergism between transcription factors TFE3 and Smad3 in transforming growth factor-beta-induced transcription of the Smad7 ...

https://en.wikipedia.org/wiki/TFE3

... family of basic-leucine zipper (bZIP) transcription factors is a multifaceted highly-regulated system for gene regulation". ... Ward AC, Loeb DM, Soede-Bobok AA, Touw IP, Friedman AD (June 2000). "Regulation of granulopoiesis by transcription factors and ... these two transcriptional factors are important for terminal granulocyte differentiation. Other transcriptional factors that ... Tsuji T, Sugimoto K, Yanai T, Takashita E, Mori KJ (1994). "Induction of granulocyte-macrophage colony-stimulating factor (GM- ...

https://en.wikipedia.org/wiki/Granulopoiesis

... basic-leucine zipper transcription factors Remove constraint Subject term: basic-leucine zipper transcription factors Start ... transcription (genetics). Abstract:. ... The basic leucine zipper (bZIP) family is one of the largest transcription factor (TF ... Malus domestica; apples; basic-leucine zipper transcription factors; drought; fruiting; gene expression regulation; genes; ... leucine zipper; models; plant growth; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; ...

https://pubag.nal.usda.gov/?f%5Bsubject_facet%5D%5B%5D=apples&f%5Bsubject_facet%5D%5B%5D=gene+expression+regulation&f%5Bsubject_facet%5D%5B%5D=genes&f%5Bsubject_term%5D%5B%5D=basic-leucine+zipper+transcription+factors&per_page=50&sort=relevance

... including transcription, telomere homeostasis and genomic instability. However, the molecular function of the complex has ... Basic-Leucine Zipper Transcription Factors / biosynthesis * Basic-Leucine Zipper Transcription Factors / genetics* ... These findings are further supported by strong genetic interactions of EKC mutants with a translation initiation factor and ... including transcription, telomere homeostasis and genomic instability. However, the molecular function of the complex has ...

https://pubmed.ncbi.nlm.nih.gov/21459853/

Basic leucine zipper domain transcription factors: the vanguards in plant immunity. Bioch. Let. 39, 1779-1791. doi: 10.1007/ ... These proteins were under the direct control of the basic region leucine-zipper transcription factor gene bZIP19. This ... a Zn-responsive transcription factor, member of the Fur family of proteins, is the most common transcription factor that ... 2010). Arabidopsis thaliana transcription factors bZIP19 and bZIP23 regulate the adaptation to zinc deficiency. Proc. Natl. ...

https://www.frontiersin.org/articles/10.3389/fpls.2019.01171/full

... focusing on the transcription factors contributions to this systemic hypersensitivity reaction. Host mutation in transcription ... While many molecules are involved in cellular regulation, the expression and regulation of transcription factors involved in ... factor expression, or deregulation of their activity in an anaphylaxis context, will be updated. So far, the risk of ... The MiTF/TFE family of basic helix-loop-helix leucine zipper (b-HLH-LZ) transcription factors includes MITF, TFEB, TFE3, and ...

https://www.mdpi.com/1422-0067/22/9/4935/htm

WRKY transcription factors are a superfamily of regulators involved in diverse biological processes and stress responses in ... Zhao, J., et al., Evolutionary and expression analyses of the apple basic leucine zipper transcription factor family. Front ... Background: WRKY transcription factors are a superfamily of regulators involved in diverse biological processes and stress ... He, G.H., et al., Drought-responsive WRKY transcription factor genes TaWRKY1 and TaWRKY33 from wheat confer drought and/or heat ...

https://www.researchsquare.com/article/rs-36113/v4

BTB and CNC homology, basic leucine zipper transcription factor 2. Bach2os. 4. 32559680 to 32571662 11982. -. antisense lncRNA ... transcription start site region 36708. Tssr36709. 4. 32615489 to 32615505 16. +. TSS region. transcription start site region ... transcription start site region 36710. Tssr36711. 4. 32626872 to 32626891 19. +. TSS region. transcription start site region ... transcription start site region 36713. Tssr36714. 4. 32672547 to 32672559 12. +. TSS region. transcription start site region ...

https://phenome.jax.org/markers/search?searchterm=4%3A32542768-32762785

Basic-leucine zipper (bZIP) transcription factor family protein. TAIR Computational Description Basic-leucine zipper (bZIP) ... Encodes a member of the BZIP family of transcription factors. Forms heterodimers with the related protein AtbZIP34. Binds to G- ... transcription factor family protein;(source:Araport11). TAIR Curator Summary ... Basic-leucine zipper (bZIP) transcription factor family protein. TAIR Aliases ATBZIP61, BZIP61. ...

https://bar.utoronto.ca/thalemine/report.do?id=5150083

Autophagy, a basic cell survival mechanism mediated by recycling of cellular amino acids, plays an important role in cancer. ... Involvement of basic leucine zipper transcription factors. J Biol Chem. 1998;273(50):33741-9. ... 5c). There are three major ER stress sensors: protein kinase RNA-like ER kinase (PERK), activating transcription factor-6 (ATF6 ... Oncogenicity of the developmental transcription factor Sox9. Cancer Res. 2012;72(5):1301-15. ...

https://bmccancer.biomedcentral.com/articles/10.1186/s12885-015-1789-5

8-tetrachlorodibenzo-p-dioxin requires the CNC basic leucine zipper transcription factor NRF2. Cross-interaction between AHR ... CYP3A4 polymorphisms - potential risk factors for breast and prostate cancer: a huge review. ...

http://www2a.cdc.gov/nioshtic-2/BuildQyr.asp?s1=genetic&f1=TI&Startyear=&t1=1&s2=genetic&terms=3&Adv=1&ct=&B1=Search&f2=KW&Limit=500&Sort=DP+DESC&D1=10&EndYear=&PageNo=445&RecNo=445&View=b&

Arabidopsis basic leucine zipper transcription factors involved in an abscisic acid-dependent signal transduction pathway under ... Arabidopsis basic leucine zipper transcription factors involved in an abscisic acid-dependent signal transduction pathway under ... Arabidopsis basic leucine zipper transcription factors involved in an abscisic acid-dependent signal transduction pathway under ... 2 proteins activated transcription by ABRE and required ABA for their activation , suppressed by protein kinase inhibitors • ...

https://www.slideserve.com/arlene/aba

... family of transcription factors consists of three functionally redundant basic-leucine zipper transcription factors, namely, ... Since the dimerization of A-CREB is based on CREB leucine zipper domain, it can form dimers with the transcription factors that ... 1998) Ca2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism. Neuron 20:709-726. ... It is also plausible that CREB acts as a nucleating factor for other, de novo synthesized transcription factors to bind the ...

https://www.jneurosci.org/content/40/7/1405

NF-E2-Related Factor 2 100% * Basic-Leucine Zipper Transcription Factors 96% ... Defining the Oxidative Stress-Related Mechanisms by which Activation of the Transcription Factor Nrf2 Arrests and Resolves ...

https://discovery.dundee.ac.uk/en/publications/nrf2-and-the-ambiguous-consequences-of-its-activation-during-init/projects/?ordering=endDate&descending=true

The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that plays an important role in the ... The encoded nuclear protein represses ETS1-mediated transcription of erythroid-specific genes in myeloid cells. This gene ...

https://www.origene.com/catalog/antibodies/primary-antibodies/ta800290s/mafb-mouse-monoclonal-antibody-clone-id-oti1e9

Basic leucine zipper transcriptional factor ATF-like (BATF) is a basic leucine zipper (bZIP) transcription factor and is part ... unlikely to become a limiting factor. Moreover, since the recombinant antibody sequence is known, continuity of supply is ...

https://www.cellsignal.com/products/primary-antibodies/batf-d7c5-rabbit-mab/8638

... transcription factor with a basic-leucine zipper motif is required for the unfolded protein-response pathway. Genes Cells. 1, ... So, you might end up obtaining many kinases but no transcription factor. And because the Institute focuses on transcription, we ... Splicing activates the mRNA, allowing it to produce a transcription factor that enters the nucleus and activates transcription ... He told me to think of a method of obtaining a transcription factor directly. But this was a difficult task. After a 14-month ...

https://laskerfoundation.org/winners/unfolded-protein-response/

Abnormally prolonged or increased activity of the Myc family of basic helix-loop-helix leucine zipper transcription factors is ... The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a co-factor for c-Myc regulated transcription ... Indeed, PI3K negatively regulates Forkhead transcription factors, which can promote cell cycle exit by repressing cyclin D( ... Previous work indicates that Shh signaling induces expression of the proto-oncogene transcription factor Nmyc1. Nmyc1 is ...

https://journals.biologists.com/dev/article/131/1/217/64407/Hedgehog-and-PI-3-kinase-signaling-converge-on

... depletion of immune cell types and in gene-modified mouse strains lacking basic leucine zipper ATF-like transcription factor 3 ... The transcription factor TCF1 and the microRNA miR-21 were regulated by DNA methylation upon CD137 costimulation. Such gene- ... expression regulatory factors can, in turn, broaden the effects of DNA methylation by controlling expression of their target ...

https://www.unav.edu/web/investigacion/nuestros-investigadores/detalle-investigadores-cv?investigadorId=131455&investigador=Molina%20Samper,%20Carmen

... a basic-helix-loop-helix and leucine zipper transcription factor, which functions as the master gene for melanocyte survival. ... It also is a key factor in regulating the transcription of the major melanogenic proteins, including tyrosinase and tyrosinase- ... This process is mainly determined by the actions of microphthalmia-associated transcription factor (MITF), ... Other melanogenic factors including SCF also are produced by keratinocytes in response to UV, and all are involved in ...

https://www.cosmeticsandtoiletries.com/cosmetic-ingredients/actives/article/21835242/lightening-skin-through-a-melanogenesis-interrupting-peptide

Basic-Leucine Zipper Transcription Factors [D12.776.260.108] * Basic Helix-Loop-Helix Leucine Zipper Transcription Factors [ ... Basic-Leucine Zipper Transcription Factors [D12.776.930.127] * Basic Helix-Loop-Helix Leucine Zipper Transcription Factors [ ... Basic Helix-Loop-Helix Transcription Factors [D12.776.260.103] * Basic Helix-Loop-Helix Leucine Zipper Transcription Factors [ ... Basic Helix-Loop-Helix Transcription Factors [D12.776.930.125] * Basic Helix-Loop-Helix Leucine Zipper Transcription Factors [ ...

https://meshb.nlm.nih.gov/record/ui?ui=D051739

... and found that ces-2 encodes a basic region leucine-zipper (bZIP) transcription factor. The CES-2 protein is most similar to ... and found that ces-2 encodes a basic region leucine-zipper (bZIP) transcription factor. The CES-2 protein is most similar to ... On the basis of these observations, we suggest that some CES-2/PAR family transcription factors are evolutionary conserved ... On the basis of these observations, we suggest that some CES-2/PAR family transcription factors are evolutionary conserved ...

https://www.zora.uzh.ch/id/eprint/1037/

Belong to a Novel Family of BTB-Basic Leucine Zipper Transcription Factors That Interact with MafK and Regulate Transcription ... components of the Leucine zipper factors class. There are 19 TFs (AP1, Fos, Fosb, Fosl1, Fosl2, Jun, Junb, Jund1, Maf, Mafb, ... Lähdesmäki H, Rust AG, Shmulevich I: Probabilistic Inference of Transcription Factor Binding from Multiple Data Sources. PLoS ... ProbTF uses genome sequences and transcription factor sequence specificities to compute the protein-DNA binding probabilities. ...

https://bmcbioinformatics.biomedcentral.com/articles/10.1186/1471-2105-10-165

Basic-Leucine Zipper Transcription Factors. M. J. Hickman, Petti, A. A., Ho-Shing, O., Silverman, S. J., R McIsaac, S., Lee, T ... Basic Helix-Loop-Helix Leucine Zipper Transcription Factors. S. R McIsaac, Petti, A. A., Bussemaker, H. J., and Botstein, D., " ... Transcription Factors. S. R McIsaac, Silverman, S. J., McClean, M. N., Gibney, P. A., Macinskas, J., Hickman, M. J., Petti, A. ... "Rapid synthesis and screening of chemically activated transcription factors with GFP-based reporters.", J Vis Exp, no. 81, p. ...

https://lsi.princeton.edu/research/publications?page=7&s=keyword&o=asc&f%5Bauthor%5D=89

Basic-Leucine Zipper Transcription Factors 97% * Cotyledon 94% * Signal Transduction 49% * Genes 25% ...

https://okayama.pure.elsevier.com/en/persons/yoko-ikeda/publications/?type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontojournal%2Farticle

Basic LEUCINE ZIPPER TRANSCRIPTION FACTOR 67 transactivates DELAY OF GERMINATION 1 to establish primary seed dormancy in ... Basic LEUCINE ZIPPER TRANSCRIPTION FACTOR 67 transactivates DELAY OF GERMINATION 1 to establish primary seed dormancy in ... Identification and analysis of proteins that interact with the Avena fatua homologue of the maize transcription factor ... Identification and analysis of proteins that interact with the Avena fatua homologue of the maize transcription factor ...

https://repository.rothamsted.ac.uk/item/987v4/laboratory-phenomics-predicts-field-performance-and-identifies-superior-indica-haplotypes-for-early-seedling-vigour-in-dry-direct-seeded-rice

CLASS III HOMEODOMAIN LEUCINE ZIPPER (HD-ZIPIII) transcription factors are involved in embryo, shoot and root patterning. ... which phosphorylates the transcription factor BASIC LEUCINE ZIPPER63 (bZIP63) that directly binds and activates the promoter of ... CLASS III HOMEODOMAIN LEUCINE ZIPPER (HD-ZIPIII) transcription factors are involved in embryo, shoot and root patterning. ... which phosphorylates the transcription factor BASIC LEUCINE ZIPPER63 (bZIP63) that directly binds and activates the promoter of ...

https://www.upsc.se/researchers/5841-schmid-markus-regulation-of-plant-growth-development-by-the-environment.html

Basic Leucine Zipper Transcription Factor Basic Leucine Zipper Transcription Factors Basic-Leucine Zipper Transcription Factor ... Basic Leucine Zipper Transcription Factor. Basic Leucine Zipper Transcription Factors. Basic-Leucine Zipper Transcription ... Basic Helix-Loop-Helix Leucine Zipper Transcription Factors [D12.776.260.108.092] Basic Helix-Loop-Helix Leucine Zipper ... Basic Helix-Loop-Helix Leucine Zipper Transcription Factors [D12.776.930.127.092] Basic Helix-Loop-Helix Leucine Zipper ...

https://decs.bvsalud.org/en/ths/resource/?id=50952

... the abnormal accumulation of c-Myc protein is also a common finding in human cancers with normal copy number and transcription ... The c-Myc oncoprotein is a short-lived basic helix-loop-helix leucine-zipper transcription factor that, together with its ... This work was supported by the National Basic Research Program of China (973 Program, grant No: 2007CB914603) and the Chinese ... Hande MP: DNA repair factors and telomere-chromosome integrity in mammalian cells. Cytogenet Genome Res. 2004, 104: 116-122. ...

https://molecular-cancer.biomedcentral.com/articles/10.1186/1476-4598-7-32

Basic-Leucine Zipper Transcription Factors 100% * Epilepsy 55% * Leukemia 53% * Liver 33% ... Aberrant expression of PAR bZIP transcription factors is associated with epileptogenesis, focus on hepatic leukemia factor. ... Basic fibroblast growth factor reduces functional and structural damage in chronic kidney disease. Villanueva, S., Contreras, F ...

https://investigadores.uandes.cl/en/organisations/medicina/publications/?ordering=type&descending=false

... and leucine zipper (ZIP) motifs. It was initially identified as a protein which bound to the µE3 site in the immunoglobulin ... Binding results in transcriptional activation and is mediated through the basic region located just N-terminal to the HLH ... and leucine zipper (ZIP) motifs. It was initially identified as a protein which bound to the µE3 site in the immunoglobulin ... Binding results in transcriptional activation and is mediated through the basic region located just N-terminal to the HLH ...

https://www.bdbiosciences.com/en-fi/products/reagents/western-blotting-and-molecular-reagents/purified-mouse-anti-mouse-tfe3.554263

This process is mainly determined by the actions of microphthalmia-associated transcription factor (MITF), a basic-helix-loop-helix and leucine zipper transcription factor, which functions as the master gene for melanocyte survival. (cosmeticsandtoiletries.com)
TFE3 is a ubiquitously expressed 50 kDa transcription factor containing both basic helix-loop-helix (bHLH) and leucine zipper (ZIP) motifs. (bdbiosciences.com)
The MiTF/TFE (MiT) family of basic helix-loop-helix leucine zipper transcription factors is composed of four closely related members, MiTF, TFE3, TFEB and TFEC, which can bind target DNA both as homo- or heterodimers. (prinsesmaximacentrum.nl)
Kreisler acts during the final stages of glomerular development - the transition between the capillary loop and mature stages - and downstream of the Pod1 basic domain helix-loop-helix transcription factor. (northwestern.edu)
Two of the regions, called the helix-loop-helix motif and the leucine-zipper motif, are critical for protein interactions. (medlineplus.gov)
Some MITF gene variants change the amino acids used to make melanocyte inducing transcription factor, which alters the helix-loop-helix or leucine-zipper motif. (medlineplus.gov)

The hepatitis B pX protein promotes dimerization and DNA binding of cellular basic region/leucine zipper proteins by targeting the conserved basic region. (umassmed.edu)
The 2014 Albert Lasker Basic Medical Research Award honors two scientists for their discoveries concerning the unfolded protein response, an intracellular quality-control system that detects harmful misfolded proteins in the endoplasmic reticulum and signals the nucleus to carry out corrective measures. (laskerfoundation.org)
It also is a key factor in regulating the transcription of the major melanogenic proteins, including tyrosinase and tyrosinase-related proteins (TRP) 1 and 2, which lead to pigmentation. (cosmeticsandtoiletries.com)
These isoforms were always co-expressed with the intact transcription factors and may act as negative regulators of MiTF/TFE proteins. (prinsesmaximacentrum.nl)
These motifs allow molecules of melanocyte inducing transcription factor to interact with each other or with other proteins that have a similar structure, creating a two-protein unit (dimer) that functions as a transcription factor. (medlineplus.gov)
In the CYTOPLASM , I-kappa B proteins bind to the transcription factor NF-KAPPA B. Cell stimulation causes its dissociation and translocation of active NF-kappa B to the nucleus. (bvsalud.org)

The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that plays an important role in the regulation of lineage-specific hematopoiesis. (origene.com)
The encoded nuclear protein represses ETS1-mediated transcription of erythroid-specific genes in myeloid cells. (origene.com)
By contrast,Shh binding to its receptor Patched (Ptc) relieves inhibition of the signaling pathway activated by the transmembrane protein Smoothened (Smo)( Ho and Scott, 2002 ),resulting in activation of Smo target genes including Ptc and the Gli family of transcription factors. (biologists.com)
An oncogenic form of the mammalian PAR-family protein, hepatic leukaemia factor (HLF), is reported to effect programmed cell death in mammalian cells. (uzh.ch)
However, the abnormal accumulation of c-Myc protein is also a common finding in human cancers with normal copy number and transcription level of c-Myc gene. (biomedcentral.com)
It is activated by PROTEASES and then moves to the CELL NUCLEUS to regulate GENETIC TRANSCRIPTION of GENES involved in the unfolded protein response. (rush.edu)
C1q/Tumor Necrosis Factor-Related Protein-9 Regulates the Fate of Implanted Mesenchymal Stem Cells and Mobilizes Their Protective Effects Against Ischemic Heart Injury via Multiple Novel Signaling Pathways. (jefferson.edu)
Homologs of the myc and max genes were cloned from the fruit fly Drosophila melanogaster and their protein products (dMyc and dMax) were shown to heterodimerize, recognize the same DNA sequence as their vertebrate homologs, and activate transcription. (fhcrc.org)
Furthermore, we observed that a considerable proportion of the TFEC transcripts splice out protein-coding exons, resulting in transcription factor isoforms lacking one or more functional domains, primarily the basic region and/or the AAD. (prinsesmaximacentrum.nl)
P-ATF1-T184 further increased the DNA binding ability, transcription activity, and stabilized the protein expression of ATF1. (biomedcentral.com)
The MITF gene provides instructions for making a protein called melanocyte inducing transcription factor. (medlineplus.gov)
On the basis of this action, the protein is called a transcription factor. (medlineplus.gov)
The MITF gene variants that cause Tietz syndrome either delete or change a single protein building block (amino acid) in the basic motif region of the melanocyte inducing transcription factor structure. (medlineplus.gov)

Binding results in transcriptional activation and is mediated through the basic region located just N-terminal to the HLH domain. (bdbiosciences.com)
A basic-leucine zipper transcription factor that was originally described as a transcriptional regulator controlling expression of the BETA-GLOBIN gene. (jefferson.edu)

These findings are further supported by strong genetic interactions of EKC mutants with a translation initiation factor and with threonine biosynthesis genes. (nih.gov)
ATF1 and CREB regulate transcription of many target genes by way of homo-or heterodimerization within the family or with other b-zip transcription factors, which relevant to an AP1 or cAMP-response element [ 2 ]. (biomedcentral.com)
It represses GENETIC TRANSCRIPTION of target genes by recruiting HISTONE DEACETYLASES . (nih.gov)

Beta-catenin regulates cell-cell adhesion by binding to E-cadherin at the cell membrane and, when translocated into the nucleus, mediates signalling by activation of transcription factors such as TCF4. (austin.org.au)
Additionally, melanocyte inducing transcription factor regulates the development of specialized cells in the eye called retinal pigment epithelial cells. (medlineplus.gov)
Some research indicates that melanocyte inducing transcription factor also regulates the development of cells that break down and remove bone (osteoclasts) and cells that play a role in allergic reactions (mast cells). (medlineplus.gov)

Arabidopsis basic leucine zipper transcription factors involved in an abscisic acid-dependent signal transduction pathway under drought and high-salinity condition. (slideserve.com)
Tetramerization of MADS family transcription factors SEPALLATA3 and AGAMOUS is required for floral meristem determinacy in Arabidopsis. (lpcv.fr)

Intramolecular inhibition of activating transcription factor-2 function by its DNA-binding domain. (umassmed.edu)
Activating Transcription Factor 6" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)
This graph shows the total number of publications written about "Activating Transcription Factor 6" by people in this website by year, and whether "Activating Transcription Factor 6" was a major or minor topic of these publications. (rush.edu)
Below are the most recent publications written about "Activating Transcription Factor 6" by people in Profiles. (rush.edu)
Studies have revealed an important role of activating transcription factor 1 (ATF1) and phosphorylated ATF1 at Ser63 in tumors. (biomedcentral.com)

Inhibition of apoptosis by ATFx: a novel role for a member of the ATF/CREB family of mammalian bZIP transcription factors. (umassmed.edu)
Fungal basic leucine zipper (bZIP) transcription factors mediate responses to oxidative stress. (mycologics.net)
While basic domain leucine zipper (bZip) transcription factors of the Maf subfamily have been implicated in cellular differentiation processes, Kreisler (Krml1/MafB), the gene affected in the mouse kreisler (kr) mutation, is known for its role in hindbrain patterning. (northwestern.edu)

Our data reveal that multiple levels of regulation exist for the MiTF/TFE family of transcription factors, which indicates how these transcription factors may participate in various cellular processes in different tissues. (prinsesmaximacentrum.nl)

Encodes a member of the BZIP family of transcription factors. (utoronto.ca)
We cloned the gene ces-2, which is required to activate programmed cell death in the sister cells of the serotoninergic neurosecretory motor (NSM) neurons, and found that ces-2 encodes a basic region leucine-zipper (bZIP) transcription factor. (uzh.ch)
The mutated gene, PORCUPINE , encodes a putative splice factor, suggesting that alternative splicing of pre-mRNA might be involved in modulating growth and development in response to changes in ambient temperature and might contribute to establish phenotypic plasticity in plants. (upsc.se)
PLATZ encodes a class of plant-specific zinc-finger transcription factor. (biomedcentral.com)

The other region, known as the basic motif, binds to specific areas of DNA, allowing the dimer to control gene activity. (medlineplus.gov)

Abstract Basic leucine zipper (bZIP) is a conserved transcription factor (TF) widely present in eukaryotes, and it plays an important role in regulating plant growth and stress responses. (scielo.org)

WRKY transcription factors are a superfamily of regulators involved in diverse biological processes and stress responses in plants. (researchsquare.com)
A large superfamily of transcription factors that contain a region rich in BASIC AMINO ACID residues followed by a LEUCINE ZIPPER domain. (bvsalud.org)

Endogenous inhibitors of nuclear factor-kB, an opportunity for cancer control. (cdc.gov)
Opt1p transports tetra- and pentapeptides, including the endogenous opioid pentapeptide leucine enkephalin. (lbl.gov)

In the current study, we have investigated this phenomenon in primary cultures of rat cortical neurons using overexpression of dominant-negative forms of several transcription factors, including CREB, ATF2, C/EBP, USF, and NFAT. (jneurosci.org)
We show that CREB family transcription factors, together with the coactivator CBP/p300, but not the CRTC family, are the main regulators of rat BDNF gene expression after TrkB signaling. (jneurosci.org)
CREB family transcription factors are required for the early induction of all the major BDNF transcripts, whereas CREB itself directly binds only to BDNF promoter IV, is phosphorylated in response to BDNF-TrkB signaling, and activates transcription from BDNF promoter IV by recruiting CBP. (jneurosci.org)
Here, we have elucidated the molecular mechanisms behind TrkB signaling-dependent BDNF mRNA induction and show that CREB family transcription factors are the main regulators of BDNF gene expression after TrkB signaling. (jneurosci.org)

Autophagy, a basic cell survival mechanism mediated by recycling of cellular amino acids, plays an important role in cancer. (biomedcentral.com)
The degradation of the amino acids proline, leucine, isoleucine and valine is strongly enhanced under these conditions, whereas asparagine, a transport molecule for carbon and nitrogen under energy limiting conditions, is synthesized in a higher amount. (uni-goettingen.de)

NF-E2-Related Factor 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (jefferson.edu)

Therefore KIN10/11 dependent activation of both bZIP factors by direct phosphorylation at these sites can be excluded. (uni-goettingen.de)

A kinase-inactive mutant PAK1(K299A) blocked the gastrin-stimulated dissociation of beta-catenin from E-cadherin, translocation of beta-catenin from the cell membrane to the nucleus, and association of beta-catenin with the transcription factor TCF4. (austin.org.au)

The effects of PI3K activity on Nmyc1 stabilization are mimicked by insulin-like growth factor, a PI3K agonist with roles in central nervous system precursor growth and tumorigenesis. (biologists.com)

On the basis of these observations, we suggest that some CES-2/PAR family transcription factors are evolutionary conserved regulators of programmed cell death. (uzh.ch)
Interactions between transcription factors and chromatin regulators in the control of flower development. (lpcv.fr)

The basic leucine zipper (bZIP) family is one of the largest transcription factor (TF) families in plants, which play crucial roles in plant growth and development. (usda.gov)

Induction of murine NAD(P)H:quinone oxidoreductase by 2,3,7,8-tetrachlorodibenzo-p-dioxin requires the CNC basic leucine zipper transcription factor NRF2. (cdc.gov)
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. (jefferson.edu)

In 2013, the third-generation clustered regularly interspaced short palindromic repeats (CRISPR)-Cas gene editing system was introduced, which corrected certain defects in the first- and second-generation gene editing systems based on the synthetic endonucleases zinc finger endonuclease (ZFN) and transcription activator-like effector nuclease (TALEN), such as the transfection inefficiency, design complexity and limitations on multiplexed mutations [ 2 ]. (biomedcentral.com)
Zinc-finger transcription factors play central roles in plant growth, development and abiotic stress responses. (biomedcentral.com)
Hence PLATZs encode a novel class of plant-specific zinc-finger transcription factors. (biomedcentral.com)

Myc acts through dimerization with Max to bind DNA and activate transcription. (fhcrc.org)

Phosphorylated ATF1 at Ser63 has been recognized as an important site for its transcription activity. (biomedcentral.com)

Melanocyte inducing transcription factor helps control the development and function of pigment-producing cells called melanocytes. (medlineplus.gov)
The structure of melanocyte inducing transcription factor includes three critically important regions. (medlineplus.gov)
Dimers incorporating the abnormal melanocyte inducing transcription factor cannot be transported into the cell nucleus to bind with DNA. (medlineplus.gov)

One of the first steps once plants are committed to flowering is the induction of the plant-specific transcription factor LEAFY in the incipient flower primordia. (upsc.se)

Although some molecularly targeted drugs, such as anti-vascular endothelial cell growth factor (VEGF) and anti-epidermal growth factor receptor (EGFR) antibodies, are used clinically and contribute to a better prognosis, the current median survival of stage IV colorectal cancer patients receiving chemotherapy is shorter than 3 years [ 2 ]. (biomedcentral.com)

Many well-characterized mitogens [e.g. insulin-like growth factor (IGF),platelet-derived growth factor] signal through receptor tyrosine kinases(RTKs) that lead to activation of the Ras-MAPK and phosphatidylinositol-3-kinase (PI3K) pathways( Marshall, 1995 ). (biologists.com)

Overall, our data provide a novel twist to understanding the primary function of the EKC/KEOPS and its impact on several essential cellular functions like transcription and telomere homeostasis. (nih.gov)

The EKC/KEOPS complex is universally conserved in Archaea and Eukarya and has been implicated in several cellular processes, including transcription, telomere homeostasis and genomic instability. (nih.gov)

The combination of BO-112 and DMXAA was chosen given its excellent efficacy and the requirements for antitumor effects were studied on selective depletion of immune cell types and in gene-modified mouse strains lacking basic leucine zipper ATF-like transcription factor 3 (BATF3), interferon-alpha/beta receptor (IFNAR) or STING. (unav.edu)

Below are the most recent publications written about "NF-E2-Related Factor 2" by people in Profiles. (jefferson.edu)

IJMS | Free Full-Text | Anaphylaxis: Focus on Transcription Factor Activity (mdpi.com)

Frontiers | Pleiotropic Roles of ChSat4 in Asexual Development, Cell Wall Integrity Maintenance, and Pathogenicity in... (frontiersin.org)

Inhibition of autophagy exerts anti-colon cancer effects via apoptosis induced by p53 activation and ER stress | BMC Cancer |... (bmccancer.biomedcentral.com)

PPT - ABA? PowerPoint Presentation, free download - ID:3820150 (slideserve.com)

Frontiers | Insight Into the Long Noncoding RNA and mRNA Coexpression Profile in the Human Blood Transcriptome Upon Leishmania... (frontiersin.org)

Anatomy5

Organisms5

Chemicals and Drugs52

Analytical, Diagnostic and Therapeutic Techniques and Equipment8

Phenomena and Processes29

Technology, Industry, Agriculture2

Information Science3

Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3. (1/1416)

Silencing of the Epstein-Barr virus latent membrane protein 1 gene by the Max-Mad1-mSin3A modulator of chromatin structure. (2/1416)

Transcriptional repression of human hepatitis B virus genes by a bZIP family member, E4BP4. (3/1416)

Two distinct interleukin-3-mediated signal pathways, Ras-NFIL3 (E4BP4) and Bcl-xL, regulate the survival of murine pro-B lymphocytes. (4/1416)

Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) encodes a homologue of the Epstein-Barr virus bZip protein EB1. (5/1416)

Multiple regulatory elements control the expression of the yeast ACR1 gene. (6/1416)

A novel human DNA-binding protein with sequence similarity to a subfamily of redox proteins which is able to repress RNA-polymerase-III-driven transcription of the Alu-family retroposons in vitro. (7/1416)

Ubiquitination and degradation of ATF2 are dimerization dependent. (8/1416)

Leucine Zippers

Basic-Leucine Zipper Transcription Factors

Transcription Factors

NF-E2-Related Factor 2

Abscisic Acid

Molecular Sequence Data

Transcription, Genetic

DNA-Binding Proteins

Promoter Regions, Genetic

G-Box Binding Factors

Proto-Oncogene Proteins c-maf

Basic Helix-Loop-Helix Leucine Zipper Transcription Factors

Gene Expression Regulation, Plant

Plant Proteins

Arabidopsis

Microphthalmia-Associated Transcription Factor

Amino Acid Sequence

Base Sequence

CCAAT-Enhancer-Binding Protein-beta

Trans-Activators

Arabidopsis Proteins

Gene Expression Regulation

Binding Sites

Protein Binding

Sequence Homology, Amino Acid

Plants, Genetically Modified

Response Elements

RNA, Messenger

Seeds

Mutation

Transcriptional Activation

Maf Transcription Factors, Large

Signal Transduction

Helix-Loop-Helix Motifs

Nuclear Proteins

Mice, Knockout

CCAAT-Enhancer-Binding Protein-alpha

Cells, Cultured

Cell Line

Upstream Stimulatory Factors

CCAAT-Enhancer-Binding Proteins

Repressor Proteins

Protein Structure, Tertiary

Cell Differentiation

Activating Transcription Factor 3

DNA

Activating Transcription Factors

Transfection

Gene Expression Regulation, Developmental

Proto-Oncogene Proteins c-jun

Dimerization

Activating Transcription Factor 4

Transcription Factor AP-1

Sp1 Transcription Factor

Recombinant Fusion Proteins

Cloning, Molecular

Cyclic AMP Response Element-Binding Protein

Activating Transcription Factor 2

Cell Nucleus

Nuclear Respiratory Factor 1

NF-E2 Transcription Factor

Basic Helix-Loop-Helix Transcription Factors

Electrophoretic Mobility Shift Assay

HeLa Cells

Sequence Alignment

Genes, Reporter

MafK Transcription Factor

NF-E2 Transcription Factor, p45 Subunit

Homeodomain Proteins

Nuclear Respiratory Factors

Saccharomyces cerevisiae Proteins

Fungal Proteins

DNA, Complementary

Forkhead Transcription Factors

Saccharomyces cerevisiae

Luciferases

Phosphorylation

Recombinant Proteins

Transcription Factor AP-2

Blotting, Western

Predicting HBZ Interaction with BATF3 Enhancer Regions Through ChIP-seq