DNA-binding motifs formed from two alpha-helixes which intertwine for about eight turns into a coiled coil and then bifurcate to form Y shaped structures. Leucines occurring in heptad repeats end up on the same sides of the helixes and are adjacent to each other in the stem of the Y (the "zipper" region). The DNA-binding residues are located in the bifurcated region of the Y.
A large superfamily of transcription factors that contain a region rich in BASIC AMINO ACID residues followed by a LEUCINE ZIPPER domain.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
A basic-leucine zipper transcription factor that was originally described as a transcriptional regulator controlling expression of the BETA-GLOBIN gene. It may regulate the expression of a wide variety of genes that play a role in protecting cells from oxidative damage.
Abscission-accelerating plant growth substance isolated from young cotton fruit, leaves of sycamore, birch, and other plants, and from potatoes, lemons, avocados, and other fruits.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.
A family of transcription factors found primarily in PLANTS that bind to the G-box DNA sequence CACGTG or to a consensus sequence CANNTG.
Maf proto-oncogene protein is the major cellular homolog of the V-MAF ONCOGENE PROTEIN. It was the first of the mammalian MAF TRANSCRIPTION FACTORS identified, and it is induced in activated T-LYMPHOCYTES and regulates GENETIC TRANSCRIPTION of INTERLEUKIN-4. c-maf is frequently translocated to an immunoglobulin locus in MULTIPLE MYELOMA.
A family of transcription factors that contain regions rich in basic residues, LEUCINE ZIPPER domains, and HELIX-LOOP-HELIX MOTIFS.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in plants.
Proteins found in plants (flowers, herbs, shrubs, trees, etc.). The concept does not include proteins found in vegetables for which VEGETABLE PROTEINS is available.
A plant genus of the family BRASSICACEAE that contains ARABIDOPSIS PROTEINS and MADS DOMAIN PROTEINS. The species A. thaliana is used for experiments in classical plant genetics as well as molecular genetic studies in plant physiology, biochemistry, and development.
A basic helix-loop-helix leucine zipper transcription factor that regulates the CELL DIFFERENTIATION and development of a variety of cell types including MELANOCYTES; OSTEOCLASTS; and RETINAL PIGMENT EPITHELIUM. Mutations in MITF protein have been associated with OSTEOPETROSIS and WAARDENBURG SYNDROME.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
A CCAAT-enhancer-binding protein found in LIVER; INTESTINES; LUNG and ADIPOSE TISSUE. It is an important mediator of INTERLEUKIN-6 signaling.
Diffusible gene products that act on homologous or heterologous molecules of viral or cellular DNA to regulate the expression of proteins.
Proteins that originate from plants species belonging to the genus ARABIDOPSIS. The most intensely studied species of Arabidopsis, Arabidopsis thaliana, is commonly used in laboratory experiments.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
PLANTS, or their progeny, whose GENOME has been altered by GENETIC ENGINEERING.
Nucleotide sequences, usually upstream, which are recognized by specific regulatory transcription factors, thereby causing gene response to various regulatory agents. These elements may be found in both promoter and enhancer regions.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
The encapsulated embryos of flowering plants. They are used as is or for animal feed because of the high content of concentrated nutrients like starches, proteins, and fats. Rapeseed, cottonseed, and sunflower seed are also produced for the oils (fats) they yield.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Processes that stimulate the GENETIC TRANSCRIPTION of a gene or set of genes.
A family of high molecular weight Maf transcription factors that contain distinct activation domains.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Recurring supersecondary structures characterized by 20 amino acids folding into two alpha helices connected by a non-helical "loop" segment. They are found in many sequence-specific DNA-BINDING PROTEINS and in CALCIUM-BINDING PROTEINS.
Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
A CCAAT-enhancer-binding protein found in LIVER; ADIPOSE TISSUE; INTESTINES; LUNG; ADRENAL GLANDS; PLACENTA; OVARY and peripheral blood mononuclear cells (LEUKOCYTES, MONONUCLEAR). Experiments with knock-out mice have demonstrated that CCAAT-enhancer binding protein-alpha is essential for the functioning and differentiation of HEPATOCYTES and ADIPOCYTES.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Established cell cultures that have the potential to propagate indefinitely.
Ubiquitously expressed basic HELIX-LOOP-HELIX MOTIF transcription factors. They bind CANNTG sequences in the promoters of a variety of GENES involved in carbohydrate and lipid metabolism.
A class of proteins that were originally identified by their ability to bind the DNA sequence CCAAT. The typical CCAAT-enhancer binding protein forms dimers and consists of an activation domain, a DNA-binding basic region, and a leucine-rich dimerization domain (LEUCINE ZIPPERS). CCAAT-BINDING FACTOR is structurally distinct type of CCAAT-enhancer binding protein consisting of a trimer of three different subunits.
Proteins which maintain the transcriptional quiescence of specific GENES or OPERONS. Classical repressor proteins are DNA-binding proteins that are normally bound to the OPERATOR REGION of an operon, or the ENHANCER SEQUENCES of a gene until a signal occurs that causes their release.
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
An activating transcription factor that plays a key role in cellular responses to GENOTOXIC STRESS and OXIDATIVE STRESS.
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Activating transcription factors were originally identified as DNA-BINDING PROTEINS that interact with early promoters from ADENOVIRUSES. They are a family of basic leucine zipper transcription factors that bind to the consensus site TGACGTCA of the cyclic AMP response element, and are closely related to CYCLIC AMP-RESPONSIVE DNA-BINDING PROTEIN.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.
Cellular DNA-binding proteins encoded by the c-jun genes (GENES, JUN). They are involved in growth-related transcriptional control. There appear to be three distinct functions: dimerization (with c-fos), DNA-binding, and transcriptional activation. Oncogenic transformation can take place by constitutive expression of c-jun.
The process by which two molecules of the same chemical composition form a condensation product or polymer.
An activating transcription factor that regulates the expression of a variety of GENES involved in amino acid metabolism and transport. It also interacts with HTLV-I transactivator protein.
A multiprotein complex composed of the products of c-jun and c-fos proto-oncogenes. These proteins must dimerize in order to bind to the AP-1 recognition site, also known as the TPA-responsive element (TRE). AP-1 controls both basal and inducible transcription of several genes.
Promoter-specific RNA polymerase II transcription factor that binds to the GC box, one of the upstream promoter elements, in mammalian cells. The binding of Sp1 is necessary for the initiation of transcription in the promoters of a variety of cellular and viral GENES.
Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
A protein that has been shown to function as a calcium-regulated transcription factor as well as a substrate for depolarization-activated CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES. This protein functions to integrate both calcium and cAMP signals.
An activating transcription factor that regulates expression of a variety of GENES including C-JUN GENES; CYCLIN A; CYCLIN D1; and ACTIVATING TRANSCRIPTION FACTOR 3.
Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
A transcription factor that controls the expression of variety of proteins including CYTOCHROME C and 5-AMINOLEVULINATE SYNTHETASE. It plays an important role in maintenance of the RESPIRATORY CHAIN of MITOCHONDRIA.
A basic-leucine zipper transcription factor that regulates GLOBIN gene expression and is related to TRANSCRIPTION FACTOR AP-1. NF-E2 consists of a small MAF protein subunit and a tissue-restricted 45 kDa subunit.
A family of DNA-binding transcription factors that contain a basic HELIX-LOOP-HELIX MOTIF.
An electrophoretic technique for assaying the binding of one compound to another. Typically one compound is labeled to follow its mobility during electrophoresis. If the labeled compound is bound by the other compound, then the mobility of the labeled compound through the electrophoretic medium will be retarded.
The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
Genes whose expression is easily detectable and therefore used to study promoter activity at many positions in a target genome. In recombinant DNA technology, these genes may be attached to a promoter region of interest.
A small Maf protein involved in differentiation of ERYTHROID CELLS. MafK was originally described as the small subunit of the NF-E2 Transcription Factor, but other small MAF PROTEINS also serve as NF-E2 subunits.
A tissue-specific subunit of NF-E2 transcription factor that interacts with small MAF PROTEINS to regulate gene expression. P45 NF-E2 protein is expressed primarily in MEGAKARYOCYTES; ERYTHROID CELLS; and MAST CELLS.
Proteins encoded by homeobox genes (GENES, HOMEOBOX) that exhibit structural similarity to certain prokaryotic and eukaryotic DNA-binding proteins. Homeodomain proteins are involved in the control of gene expression during morphogenesis and development (GENE EXPRESSION REGULATION, DEVELOPMENTAL).
A family of transcription factors that control expression of a variety of nuclear GENES encoding proteins that function in the RESPIRATORY CHAIN of the MITOCHONDRIA.
Proteins obtained from the species SACCHAROMYCES CEREVISIAE. The function of specific proteins from this organism are the subject of intense scientific interest and have been used to derive basic understanding of the functioning similar proteins in higher eukaryotes.
Proteins found in any species of fungus.
Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.
A subclass of winged helix DNA-binding proteins that share homology with their founding member fork head protein, Drosophila.
A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement.
Enzymes that oxidize certain LUMINESCENT AGENTS to emit light (PHYSICAL LUMINESCENCE). The luciferases from different organisms have evolved differently so have different structures and substrates.
The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.
Proteins prepared by recombinant DNA technology.
A family of DNA binding proteins that regulate expression of a variety of GENES during CELL DIFFERENTIATION and APOPTOSIS. Family members contain a highly conserved carboxy-terminal basic HELIX-TURN-HELIX MOTIF involved in dimerization and sequence-specific DNA binding.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.
Motifs in DNA- and RNA-binding proteins whose amino acids are folded into a single structural unit around a zinc atom. In the classic zinc finger, one zinc atom is bound to two cysteines and two histidines. In between the cysteines and histidines are 12 residues which form a DNA binding fingertip. By variations in the composition of the sequences in the fingertip and the number and spacing of tandem repeats of the motif, zinc fingers can form a large number of different sequence specific binding sites.
A technique for identifying specific DNA sequences that are bound, in vivo, to proteins of interest. It involves formaldehyde fixation of CHROMATIN to crosslink the DNA-BINDING PROTEINS to the DNA. After shearing the DNA into small fragments, specific DNA-protein complexes are isolated by immunoprecipitation with protein-specific ANTIBODIES. Then, the DNA isolated from the complex can be identified by PCR amplification and sequencing.
The functional hereditary units of PLANTS.
Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.
Screening techniques first developed in yeast to identify genes encoding interacting proteins. Variations are used to evaluate interplay between proteins and other molecules. Two-hybrid techniques refer to analysis for protein-protein interactions, one-hybrid for DNA-protein interactions, three-hybrid interactions for RNA-protein interactions or ligand-based interactions. Reverse n-hybrid techniques refer to analysis for mutations or other small molecules that dissociate known interactions.
A family of zinc finger transcription factors that share homology with Kruppel protein, Drosophila. They contain a highly conserved seven amino acid spacer sequence in between their ZINC FINGER MOTIFS.
The so-called general transcription factors that bind to RNA POLYMERASE II and that are required to initiate transcription. They include TFIIA; TFIIB; TFIID; TFIIE; TFIIF; TFIIH; TFII-I; and TFIIJ. In vivo they apparently bind in an ordered multi-step process and/or may form a large preinitiation complex called RNA polymerase II holoenzyme.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Annual cereal grass of the family POACEAE and its edible starchy grain, rice, which is the staple food of roughly one-half of the world's population.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Any of the processes by which cytoplasmic factors influence the differential control of gene action in viruses.
Cis-acting DNA sequences which can increase transcription of genes. Enhancers can usually function in either orientation and at various distances from a promoter.
Nucleic acid sequences involved in regulating the expression of genes.
A ubiquitously expressed zinc finger-containing protein that acts both as a repressor and activator of transcription. It interacts with key regulatory proteins such as TATA-BINDING PROTEIN; TFIIB; and ADENOVIRUS E1A PROTEINS.
A signal transducer and activator of transcription that mediates cellular responses to INTERLEUKIN-6 family members. STAT3 is constitutively activated in a variety of TUMORS and is a major downstream transducer for the CYTOKINE RECEPTOR GP130.
A GATA transcription factor that is expressed in the MYOCARDIUM of developing heart and has been implicated in the differentiation of CARDIAC MYOCYTES. GATA4 is activated by PHOSPHORYLATION and regulates transcription of cardiac-specific genes.
Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.
The major sequence-specific DNA-binding component involved in the activation of transcription of RNA POLYMERASE II. It was originally described as a complex of TATA-BOX BINDING PROTEIN and TATA-BINDING PROTEIN ASSOCIATED FACTORS. It is now know that TATA BOX BINDING PROTEIN-LIKE PROTEINS may take the place of TATA-box binding protein in the complex.

Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3. (1/1416)

The NF-E2-binding sites or Maf recognition elements (MARE) are essential cis-acting elements in the regulatory regions of erythroid-specific genes recognized by the erythroid transcription factor NF-E2, composed of p45 and MafK. Recently, two p45-related factors Nrf1 and Nrf2 were isolated, and they are now collectively grouped as the Cap'n' collar (CNC) family. CNC factors bind to MARE through heterodimer formation with small Maf proteins. We report here the identification and characterization of a novel CNC factor, Nrf3, encoding a predicted 73-kDa protein with a basic region-leucine zipper domain highly homologous to those of other CNC proteins. In vitro and in vivo analyses showed that Nrf3 can heterodimerize with MafK and that this complex binds to the MARE in the chicken beta-globin enhancer and can activate transcription. Nrf3 mRNA is highly expressed in human placenta and B cell and monocyte lineage. Chromosomal localization of human Nrf3 is 7p14-15, which lies near the hoxA gene locus. As the genetic loci of p45, nrf1, and nrf2 have been mapped close to those of hoxC, hoxB, and hoxD, respectively, the present study strongly argues for the idea that a single ancestral gene for the CNC family members may have been localized near the ancestral Hox cluster and have diverged to give rise to four closely related CNC factors through chromosome duplication.  (+info)

Silencing of the Epstein-Barr virus latent membrane protein 1 gene by the Max-Mad1-mSin3A modulator of chromatin structure. (2/1416)

The tumor-associated latent membrane protein 1 (LMP1) gene in the Epstein-Barr virus (EBV) genome is activated by EBV-encoded proteins and cellular factors that are part of general signal transduction pathways. As previously demonstrated, the proximal region of the LMP1 promoter regulatory sequence (LRS) contains a negative cis element with a major role in EBNA2-mediated regulation of LMP1 gene expression in B cells. Here, we show that this silencing activity overlaps with a transcriptional enhancer in an LRS sequence that contains an E-box-homologous motif. Mutation of the putative repressor binding site relieved the repression both in a promoter-proximal context and in a complete LRS context, indicating a functional role of the repressor. Gel retardation assays showed that members of the basic helix-loop-helix transcription factor family, including Max, Mad1, USF, E12, and E47, and the corepressor mSin3A bound to the E-box-containing sequence. The enhancer activity correlated with the binding of USF. Moreover, the activity of the LMP1 promoter in reporter constructs was upregulated by overexpression of USF1 and USF2a, and the transactivation was inhibited by the concurrent expression of Max and Mad1. This suggests that Max-Mad1-mediated anchorage of a multiprotein complex including mSin3A and histone deacetylases to the E-box site constitutes the basis for the repression. Removal of acetyl moieties from histones H3 and H4 should result in a chromatin structure that is inaccessible to transcription factors. Accordingly, inhibition of deacetylase activity with trichostatin A induced expression of the endogenous LMP1 gene in EBV-transformed cells.  (+info)

Transcriptional repression of human hepatitis B virus genes by a bZIP family member, E4BP4. (3/1416)

Box alpha is an essential element of both the upstream regulatory sequence of the core promoter and the second enhancer, which positively regulate the transcription of human hepatitis B virus (HBV) genes. In this paper, we describe the cloning and characterization of a box alpha binding protein, E4BP4. E4BP4 is a bZIP type of transcription factor. Overexpression of E4BP4 represses the stimulating activity of box alpha in the upstream regulatory sequence of the core promoter and the second enhancer in differentiated human hepatoma cell lines. E4BP4 can also suppress the transcription of HBV genes and the production of HBV virions in a transient-transfection system that mimics the viral infection in vivo. Expression of an E4BP4 antisense transcript can, instead, elevate the transcription of the core promoter. A low abundance of E4BP4 protein and mRNA in differentiated human hepatoma cell lines is detected, and E4BP4 is not a major component of box alpha binding proteins in untransfected differentiated human hepatoma cell lines. C/EBPalpha and C/EBPbeta, in contrast, are major components of the box alpha binding activity present in nuclear extracts. E4BP4 has a stronger binding affinity towards box alpha than the endogenous box alpha binding activity present in nuclear extracts. Structure and function analysis of E4BP4 reveals that DNA binding activity is sufficient to confer the negative regulatory function of E4BP4. These results indicate that binding site occlusion is the mechanism whereby E4BP4 suppresses transcription in HBV.  (+info)

Two distinct interleukin-3-mediated signal pathways, Ras-NFIL3 (E4BP4) and Bcl-xL, regulate the survival of murine pro-B lymphocytes. (4/1416)

Hematopoietic cells require cytokine-initiated signals for survival as well as proliferation. The pathways that transduce these signals, ensuring timely regulation of cell fate genes, remain largely undefined. The NFIL3 (E4BP4) transcription factor, Bcl-xL, and constitutively active mutants of components in Ras signal transduction pathways have been identified as key regulation proteins affecting murine interleukin-3 (IL-3)-dependent cell survival. Here we show that expression of NFIL3 is regulated by oncogenic Ras mutants through both the Raf-mitogen-activated protein kinase and phosphatidylinositol 3-kinase pathways. NFIL3 inhibits apoptosis without affecting Bcl-xL expression. By contrast, Bcl-xL levels are regulated through the membrane proximal portion in the cytoplasmic domain of the receptor (betac chain), which is shared by IL-3 and granulocyte-macrophage colony-stimulating factor. Activation of either pathway alone is insufficient to ensure cell survival, indicating that multiple independent signal transduction pathways mediate the survival of developing B-lymphoid cells.  (+info)

Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) encodes a homologue of the Epstein-Barr virus bZip protein EB1. (5/1416)

Analysis of the recently completed genomic sequence of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) revealed that ORF 50 encodes a protein with homology to the Epstein-Barr virus (EBV) transcription factor R. In this report, we show that ORF K8, contiguous to ORF 50, is interrupted by two introns and that the spliced RNA is translated into a bZip protein that has homology to the EBV transcription factor EB1. The newly characterized K8 protein forms homodimers but does not heterodimerize with other members of the bZip protein family.  (+info)

Multiple regulatory elements control the expression of the yeast ACR1 gene. (6/1416)

The ACR1 gene, encoding a succinate-fumarate transporter, is required by the yeast Saccharomyces cerevisiae for ethanol utilization. Accordingly, gene expression is induced by ethanol and repressed by glucose. Here, we investigated three carbon source response elements present in its promoter region. Specific deletions as well as functional analysis of the elements in a heterologous promoter confirmed their role in transcriptional regulation. Protein binding to carbon source response elements of the ICL1 promoter was competed by all three elements to various extents by the respective ACR1 sequences. In addition, two putative stress response promoter elements present in the ACR1 promoter were investigated in deletion analyses and shown to contribute to gene expression.  (+info)

A novel human DNA-binding protein with sequence similarity to a subfamily of redox proteins which is able to repress RNA-polymerase-III-driven transcription of the Alu-family retroposons in vitro. (7/1416)

In this study we identified a novel protein which may contribute to the transcriptional inactivity of Alu retroposons in vivo. A human cDNA clone encoding this protein (ACR1) was isolated from a human expression library using South-western screening with an Alu subfragment, implicated in the regulation of Alu in vitro transcription and interacting with a HeLa nuclear protein down-regulated in adenovirus-infected cells. Bacterially expressed ACR1 is demonstrated to inhibit RNA polymerase III (Pol III)-dependent Alu transcription in vitro but showed no repression of transcription of a tRNA gene or of a reporter gene under control of a Pol II promoter. ACR1 mRNA is also found to be down-regulated in adenovirus-infected HeLa cells, consistent with a possible repressor function of the protein in vivo. ACR1 is mainly (but not exclusively) located in cytoplasm and appears to be a member of a weakly characterized redox protein family having a central, highly conserved sequence motif, PGAFTPXCXXXXLP. One member of the family identified earlier as peroxisomal membrane protein (PMP)20 is known to interact in a sequence-specific manner with a yeast homolog of mammalian cyclosporin-A-binding protein cyclophilin, and mammalian cyclophilin A (an abundant ubiquitously expressed protein) is known to interact with human transcriptional repressor YY1, which is a major sequence-specific Alu-binding protein in human cells. It appears, therefore, that transcriptional silencing of Alu in vivo is a result of complex interactions of many proteins which bind to its Pol III promoter.  (+info)

Ubiquitination and degradation of ATF2 are dimerization dependent. (8/1416)

Ubiquitination and proteasome-dependent degradation are key determinants of the half-lives of many transcription factors. Homo- or heterodimerization of basic region-leucine zipper (bZIP) transcription factors is required for their transcriptional activities. Here we show that activating transcription factor 2 (ATF2) heterodimerization with specific bZIP proteins is an important determinant of the ubiquitination and proteasome-dependent degradation of ATF2. Depletion of c-Jun as one of the ATF2 heterodimer partners from the targeting proteins decreased the efficiency of ATF2 ubiquitination in vitro, whereas the addition of exogenously purified c-Jun restored it. Similarly, overexpression of c-Jun in 293T human embryo kidney cells increased ATF2 ubiquitination in vivo and reduced its half-life in a dose-dependent manner. Mutations of ATF2 that disrupt its dimerization inhibited ATF2 ubiquitination in vitro and in vivo. Conversely, removal of residues 150 to 248, as in a constitutively active ATF2 spliced form, enhanced ATF2 dimerization and transactivation, which coincided with increased ubiquitination and decreased stability. Our findings indicate the increased sensitivity of transcriptionally active dimers of ATF2 to ubiquitination and proteasome-dependent degradation. Based on these observations, we conclude that increased targeting of a transcriptionally active ATF2 form indicates the mechanism by which the magnitude and the duration of the cellular stress response are regulated.  (+info)

nitrogen-rich conditions. URS1-CYC1-Ub-X-lacZ reporters were expressed in mitotic repression machinery mutants (ume6Δ, rpd3Δ, sin3Δ, isw2Δ and itc1Δ) under nitrogen rich conditions. The data presented here from these experiments not only corroborates their known role in repression at URS1 but also suggested regulation at additional sites in the minimal CYC1 promoter. Deletion of Sin3p suggested independent repression function separable from Rpd3p. Isw2p also acts independently of Itc1p at sites other than URS1. We also show that pseudohyphal growth was stimulated by non-fermentable carbon sources in sporulation efficient SK1 genetic background. The data also indicates that stimulation of pseudohyphal growth by non-fermentable carbon sources does not require respiration function or functional mitochondrial RTG pathway. ...
Soil salinity severely affects plant growth and agricultural productivity. AtbZIP24 encodes a bZIP transcription factor that is induced by salt stress in Ambidopsis thaliana but suppressed in the salt-tolerant relative Lobularia maritima. Transcriptional repression of AtbZIP24 using RNA interference improved salt tolerance in A. thaliana. Under non-stress growth conditions, transgenic A. thaliana lines with decreased AtbZIP24 expression activated the expression of stress-inducible genes involved in cytoplasmic ion homeostasis and osmotic adjustment: the Na+ transporter AtHKT1, the Na+/H+ antiporter AtSOS1, the aquaporin AtPIP2.1, and a glutamine synthetase. In addition, candidate target genes of AtbZIP24 with functions in plant growth and development were identified such as an argonaute (AGO1)-related protein and cyclophilin AtCYP19. The salt tolerance in transgenic plants correlated with reduced Na+ accumulation in leaves. In vivo interaction of AtbZIP24 as a homodimer was shown using ...
Background: Nitrogen and light are two major regulators of plant metabolism and development. While genes involved in the control of each of these signals have begun to be identified, regulators that integrate gene responses to nitrogen and light signals have yet to be determined. Here, we evaluate the role of bZIP1, a transcription factor involved in light and nitrogen sensing, by exposing wild-type (WT) and bZIP1 T-DNA null mutant plants to a combinatorial space of nitrogen (N) and light (L) treatment conditions and performing transcriptome analysis. We use ANOVA analysis combined with clustering and Boolean modeling, to evaluate the role of bZIP1 in mediating L and N signaling genome-wide.Results: This transcriptome analysis demonstrates that a mutation in the bZIP1 gene can alter the L and/or N-regulation of several gene clusters. More surprisingly, the bZIP1 mutation can also trigger N and/or L regulation of genes that are not normally controlled by these signals in WT plants. This analysis ...
Lateral organs formed by the shoot apical meristem (SAM) are separated from surrounding stem cells by regions of low growth called boundaries. Arabidopsis (Arabidopsis thaliana) BLADE-ON-PETIOLE1 (BOP1) and BOP2 represent a class of genes important for boundary patterning in land plants. Members of this family lack a DNA-binding domain and interact with TGACG-motif binding (TGA) basic Leu zipper (bZIP) transcription factors for recruitment to DNA. Here, we show that clade I bZIP transcription factors TGA1 and TGA4, previously associated with plant defense, are essential cofactors in BOP-dependent regulation of development. TGA1 and TGA4 are expressed at organ boundaries and function in the same genetic pathways as BOP1 and BOP2 required for SAM maintenance, flowering, and inflorescence architecture. Further, we show that clade I TGAs interact constitutively with BOP1 and BOP2, contributing to activation of ARABIDOPSIS THALIANA HOMEOBOX GENE1, which is needed for boundary establishment. These ...
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Batf2 belongs to the AP-1 basic leucine zipper transcription factor (activating transcription factor) family proteins, composed of Batf, Batf2, and Batf3 (26-29, 35), with Batf2 having very limited functional information available. Batf family proteins do not have a DNA binding domain and bind to DNA indirectly with support of other transcription factors. In this study, we demonstrate that Batf2 is involved in gene regulation of IFN-γ-activated classical macrophages as well as LPS/TLR-induced macrophage stimulation. Batf2, most probably in complex with the transcription factor Irf1, induces important classical effector genes in macrophages, among them Tnf, Nos2, Ccl5, and Il12b for inflammatory responses against type 1 infectious diseases, such as M. tuberculosis.. Gene expression studies in IFN-γ-activated M1 and in TLR-stimulated macrophages revealed a strong induction of the transcription factor Batf2, which was not observed in unstimulated or IL-4-activated M2, and hence Batf2 can be ...
November 22, 2017. A research group at Lund University in Sweden has found that when the HLF (hepatic leukemia factor) gene -which is expressed in immature blood cells - does not shut down on time, we are unable to develop a functional long-term immune system. This could be a very early stage of leukemia.. Blood stem cells give rise to all of our blood cells: the red blood cells that transport oxygen, the platelets that enable blood coagulation, and our immune cells that protect us from infections. Immune cells can, in turn, be divided into two groups; one that consists of cells with a very short life expectancy and a natural but rather unspecific ability to counteract infections (myeloid cells), and another that, in contrast, consists of very long-lived cells (lymphocytes) that specialise in combatting specific bacteria and viruses.. The ability of blood stem cells to form all types of blood cells is a fundamental property that is also utilized in connection with bone marrow transplants. An ...
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mitochondrial transcription termination factor-related / mTERF-related; FUNCTIONS IN: molecular_function unknown; INVOLVED IN: biological_process unknown; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Mitochodrial transcription termination factor-related (InterPro:IPR003690); BEST Arabidopsis thaliana protein match is: mitochondrial transcription termination factor-related / mTERF-related (TAIR:AT2G03050.1); Has 469 Blast hits to 329 proteins in 46 species: Archae - 0; Bacteria - 0; Metazoa - 20; Fungi - 0; Plants - 400; Viruses - 0; Other Eukaryotes - 49 (source: NCBI BLink ...
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To unravel the biological function of Cap1p in C. albicans, we deleted the CAP1 gene in strain CAI4 and analyzed the consequence of this deletion on (i) the level of expression of Cap1p transcriptional targets and (ii) the susceptibility of the cells to a variety of toxic compounds. On the one hand, we found that deletion of CAP1 has no effect on the basal transcription of the genes analyzed, although these genes were found to be Cap1p transcriptional targets, as shown by their upregulation in theCAP1-TR transformants (Fig. 4). This observation is consistent with what has been found in S. cerevisiae for Yap1p targets such as YCF1, GSH1, andTRX2, whose expression is not reduced in a yap1deletion strain under noninducing conditions (50, 56). Rather, Yap1p has been shown to be required for stress-induced transcriptional activation of its targets (50), a situation mimicked by elevated gene dosage (56) or by expression of Yap1p derivatives carrying an altered CRD (see below). On the other hand, we ...
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hypothetical protein, A306_16176, Anapl_09380, AS27_04981, AS28_10071, BTB and CNC homolog 2, BTB and CNC homology 1, basic leucine zipper transcription facto, BTB and CNC homology 1, basic leucine zipper transcription factor 2, BTB and CNC homology 2, BTB and CNC homology, basic leucine zipper transcription factor 2, BTB and CNC-like protein 2, BTB and CNC-like proteiny 1, basic leucine zipper transcription factor 2, BTBD25, CB1_000371003, D623_10023882, EGK_15169, GW7_21221, H920_09183, M91_21520, N300_01162, N301_04236, N302_15591, N303_00283, N306_11786, N307_06313, N309_15054, N312_12567, N320_02542, N321_10716, N322_10547, N324_08521, N325_01813, N326_10621, N327_13435, N329_07672, N330_12030, N332_00603, N333_12747, N334_07268, N335_02849, N336_03526, N339_08762, N340_07775, N341_06653, PAL_GLEAN10025165, PANDA_014576, RGD1562865, Transcription regulator protein BACH2, Transcription regulator protein BACH2 (BTB and CNC homolog 2), transcription regulator protein BACH2-like protein, ...
Read Bipartite determinants of DNA-binding specificity of plant basic leucine zipper proteins, Plant Molecular Biology on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
The basic leucine zipper transcription factor ATF5 is overexpressed in many tumor types and interference with its expression or function inhibits cancer cell survival. As a potential therapeutic approach to exploit these findings, we created dominant-negative (DN) ATF5 forms lacking DNA-binding ability that retain the ATF5 leucine zipper, and thus associate with and sequester ATF5s requisite leucine zipper-binding partners. Preclinical studies with DN-ATF5, including a cell-penetrating form, show in vitro and in vivo efficacy in compromising cancer cell survival. However, DN-ATF5s targets, and particularly those required for tumor cell survival, have been unknown. We report that cells lacking ATF5 succumb to DN-ATF5, indicating that ATF5 itself is not DN-ATF5s obligate target. Unbiased pull-down assays coupled with mass spectrometry and immunoblotting revealed that DN-ATF5 associates in cells with the basic leucine zipper proteins CEBPB and CEBPD and coiled-coil protein CCDC6. Consistent with ...
The Oxidative Stress Responsive Transcription Factor Pap1 Confers DNA Damage Resistance on Checkpoint-Deficient Fission Yeast Cells. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
According to the prediction of the involvement of bZIP transcription factors in the ER stress response, AtbZIP60 was identified by genome-wide screening based on genomic information on Arabidopsis. Tunicamycin and other reagents activating the ER stress response induced transcripts of AtbZIP60. From these results, we predicted that AtbZIP60 plays a role in the ER stress response. Because the expression profile of AtbZIP60 was close to that of BiP, induction of AtbZIP60 transcript was not considered to be the first trigger of activation for BiP expression. Instead, it was assumed that a conformational change of AtbZIP60 activates the expression of chaperone genes, such as BiP. This prediction was based on the fact that AtbZIP60 contains a putative TMD like that of ATF6 in mammalian cells. Specifically, it was hypothesized that AtbZIP60 is converted to a soluble form by ER stress and becomes localized to the nucleus, resulting in the activation of chaperone genes. Indeed, a truncated form of ...
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
Monoclonal antibody against BTB and CNC homology 1, basic leucine zipper transcription factor 2 expressed by BACH2 for use in Immunoprecipitation, Microarray against Human
The physiological roles of the mitochondrial transcription termination factor (mTERF) family are poorly understood. MTERF and its homologues influence transcriptional readthrough in vitro, but the extent to which they regulate mitochondrial RNA levels in vivo is unclear. In addition, MTERF was previously shown to promote replication pausing. To test their roles in mtDNA metabolism, we created cell-lines inducibly expressing epitope-tagged versions of two members of the mTERF family, MTERFD1 and MTERFD3, as well as shRNA constructs targeted at each. We confirmed mitochondrial targeting and lack of sequence-specific DNA binding for both factors. Over-expression of epitope-tagged MTERFD1 or MTERFD3 resulted in modest mtDNA copy-number depletion and an accumulation of specific mtDNA replication intermediates indicating an impairment of the terminal steps of replication. These findings further implicate the mTERF family in restraining replication fork progression and support the idea that they ...
The basic leucine zipper transcription factor C/EBPa, required for the in vivo transition of common myeloid progenitor-to-GM progenitor. Myelomonocyte... read full [Essay Sample] for free
G-protein coupled receptor kinase 1 (Grk1) is essential for light-activated opsin phosphorylation in phototransduction shutoff, and genetic defects cause Oguchis disease, a form of Retinitis Pigmentosa (RP). To elucidate the recovery function of cone pigments, we combined Grk1-/- murine knockouts with the Neural retina leucine zipper (Nrl-/-), which have an enhanced S-cone phenotype. We observed that with increasing age and independent of light, the retinas of Nrl-/-Grk1-/- when compared to Nrl-/- developed progressive cone degeneration and decreased cone protein expression. The degeneration initially occurs in the central inferior quadrant and spreads with retinal pigment epithelia (RPE) atrophy. Endothelial cell specific immunohistochemistry and fluorescein angiography (FA) revealed progressive changes in retinal neovascularization in the Nrl-/-Grk1-/- at 1 month of age, prior to the onset of significant cone functional deficits and ONL thinning. Vascular Endothelial Growth Factor (VEGF) ...
BACH1 antibody [N2C1], Internal (BTB and CNC homology 1, basic leucine zipper transcription factor 1) for WB. Anti-BACH1 pAb (GTX110292) is tested in Human samples. 100% Ab-Assurance.
The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA and recruiting Sin3 corepressor proteins through its N-terminal Sin3-interaction domain [1][4] ...
endothelial PAS domain-containing protein 1: a Per-Arnt/AhR-Sim basic helix-loop-helix factor similar to hypoxia-inducible factor 1alpha; RefSeq NM_010137 (mouse); do not confuse with hepatic leukemia factor
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El Archivo Digital UPM alberga en formato digital la documentacion academica y cientifica (tesis, pfc, articulos, etc..) generada en la Universidad Politecnica de Madrid.Los documentos del Archivo Digital UPM son recuperables desde buscadores: Google, Google Academics, Yahoo, Scirus, etc y desde recolectores OAI: E-ciencia, DRRD, Recolecta (REBIUN-FECYT), Driver, Oaister, etc.
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p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
The KOMP Repository is located at the University of California Davis and Childrens Hospital Oakland Research Institute. Question? Comments? For Mice, Cells, and germplasm please contact us at [email protected], US 1-888-KOMP-MICE or International +1-530-752-KOMP, or for vectors [email protected] or +1-510-450-7917 ...
Myc and Max proteins complexed with target DNA (deoxyribonucleic acid). Computer model showing human Myc proto-oncogene protein (purple) and Max protein (green) complexed with synthetic DNA (red, beige). - Stock Image C035/8134
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BZW2 overexpression lysate, 0.1 mg. Transient overexpression lysate of basic leucine zipper and W2 domains 2 (BZW2), transcript variant 2
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ATF6 (activating transcription factor 6) is a basic leucine zipper transcription factor. Upon Grp78 dissociation, the entire ... Involvement of basic leucine zipper transcription factors". The Journal of Biological Chemistry. 273 (50): 33741-9. doi:10.1074 ... is upregulated downstream of the bZIP transcription factor ATF4 (activating transcription factor 4) and uniquely responsive to ... The activated transcription factor upregulates UPR 'stress genes' by directly binding to stress element promoters in the ...
Basic Domains 1.1 Class: Leucine zipper factors (bZIP) 1.1.1 Family: AP-1(-like) components; includes (c-Fos/c-Jun) 1.1.2 ... This is also true with transcription factors: Not only do transcription factors control the rates of transcription to regulate ... DNA within nucleosomes is inaccessible to many transcription factors. Some transcription factors, so-called pioneer factors are ... an important class of transcription factors called general transcription factors (GTFs) are necessary for transcription to ...
The C/EBPs follow a general basic-leucine zipper (bZIP) domain at the C-terminus and are able to form dimers with other C/EBPs ... It is essential to the transcription that these core binding factors (also referred to as nuclear factor Y or NF-Y) are able to ... from the initial transcription site or a eukaryote gene in which a complex of general transcription factors bind with RNA ... This box along with the GC box is known for binding general transcription factors. Both of these consensus sequences belong to ...
MITF is a basic helix-loop-helix leucine zipper transcription factor involved in lineage-specific pathway regulation of many ... MITF and TFE3 are both part of the basic helix-loop-helix-leucine zipper family of transcription factors. Each protein encoded ... Microphthalmia-associated transcription factor also known as class E basic helix-loop-helix protein 32 or bHLHe32 is a protein ... "The microphthalmia transcription factor and the related helix-loop-helix zipper factors TFE-3 and TFE-C collaborate to activate ...
The basic leucine zipper (bZIP) domain is found mainly in eukaryotes and to a limited extent in bacteria. The bZIP domain ... DBD database of predicted transcription factors Kummerfeld SK, Teichmann SA (January 2006). "DBD: a transcription factor ... For example, proteins that regulate transcription by binding DNA are called transcription factors. The final output of most ... the leucines can interact as the teeth in a zipper, allowing dimerization of two proteins. When binding to the DNA, basic amino ...
SREBPs belong to the basic-helix-loop-helix leucine zipper class of transcription factors.[2] Unactivated SREBPs are attached ... a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene". Cell ... Gasic GP (Apr 1994). "Basic-helix-loop-helix transcription factor and sterol sensor in a single membrane-bound molecule". Cell ... Sterol regulatory element-binding proteins (SREBPs) are transcription factors that bind to the sterol regulatory element DNA ...
1.3)bHLH-ZIP(英语:Basic helix-loop-helix leucine zipper transcription factors) ... 转录激活因子(英语:Activating transcription factor)(AATF(英语:Apoptosis-antagonizing transcription factor)、1、2、3、4、5、6、7) · AP-1(c-Fos、 ... sequence-specific enhancer binding RNA polymerase II transcription factor activity. · transcription factor binding. · zinc ion ... Chicken ovalbumin upstream promoter-transcription factor)(I、II)、Ear-2(英语:V-erbA-related gene)、HNF4(英语:Hepatocyte nuclear factor ...
... family of transcription factors contain a bHLH (basic helix-loop-helix) structural and LZ (leucine zipper) motives. Through ... repressing transcription factor binding. • RNA polymerase II transcription factor activity, sequence-specific DNA binding. • ... while the leucine zipper TF-binding motif allows the dimerization with its partner Max, another bHLH transcription factor. ... activating transcription factor binding. Cellular component. • cytosol. • nucleoplasm. • protein complex. • nucleolus. • ...
The promoter of TMEM39B transcript variant 1 contains numerous transcription factor binding sites. The transcription factors ... which is not predicted to form a leucine zipper. There is an "F..Y" motif with three repeats from amino acids 183-202 and a ... making it basic overall. It contains two pairs of tandem repeats: "GSSG" from amino acids 21-28 and "PPSH" from amino acids 107 ... and CMYB have binding sites with high affinity near the binding site of transcription factor IIB, so they are potential ...
Zhao, H.; Cao, Y.; Grunz, H. (2003). "Xenopus X-box binding protein 1, a leucine zipper transcription factor, is involved in ... Song, Jihwan; Slack, Jonathan M.W. (1994). "Spatial and temporal expression of basic fibroblast growth factor (FGF-2) mRNA and ... "Xenopus VegT RNA is localized to the vegetal cortex during oogenesis and encodes a novel T-box transcription factor involved in ... During fertilization, the sperm provides three essential parts to the oocyte: (1) a signalling or activating factor, which ...
45] SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein ... 47] SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis. Cell. 1994 Apr 8; 77 (1) :53-62 ... 50] The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell. 1 ... 22] Domain map of the LDL receptor: sequence homology with the epidermal growth factor precursor . Cell. 1984 Jun; 37 (2) :577- ...
... leucine zipper within a coiled-coil. These three motifs lie within exon 5, 16 and 17. The areas are either expressed or ... researchers registered 56 different transcripts that showed homology to transcription factors, cell cycle regulators, metabolic ... This novel gene is homologous to the FAM193 A using the National Center for Biotechnology Information Basic Local Alignment ... These aspects of the transcription mechanism differ between S. pombe and S. cerevisiae, but are conserved between S. pombe and ...
1) Basic domains. (1.1) Basic leucine zipper (bZIP). *Activating transcription factor *AATF ... Zinc finger transcription factors or ZF-TFs, are transcription factors composed of a zinc finger-binding domain and any of a ... Zinc finger transcription factor. From Wikipedia, the free encyclopedia. (Redirected from Zinc finger protein transcription ... genes in order to control the transcription of all these genes with a single transcription factor. Also, it is possible to ...
"Differential interactions of Id proteins with basic-helix-loop-helix transcription factors". J. Biol. Chem. 272 (32): 19785-93 ... Gupta K, Anand G, Yin X, Grove L, Prochownik EV (March 1998). "Mmip1: a novel leucine zipper protein that reverses the ... transcription factor activity, sequence-specific DNA binding. • transcription factor binding. • chromatin binding. • nuclear ... transcription coactivator activity. • RNA polymerase II transcription factor activity, sequence-specific DNA binding. • ...
basic helix-loop-helix[47]. InterPro: IPR001092 Pfam PF00010 SCOP 47460 basic-leucine zipper (bZIP)[48]. InterPro: IPR004827 ... This is also true with transcription factors: Not only do transcription factors control the rates of transcription to regulate ... DNA within nucleosomes is inaccessible to many transcription factors. Some transcription factors, so-called pioneering factors ... 1 Superclass: Basic Domains *1.1 Class: Leucine zipper factors (bZIP) *1.1.1 Family: AP-1(-like) components; includes (c-Fos/c- ...
1) Basic domains. (1.1) Basic leucine zipper (bZIP). *Activating transcription factor *AATF ... A sigma factorfactor) is a protein needed only for initiation of transcription.[1] It is a bacterial transcription ... Sigma factors in E. coli:. *σ70(RpoD) - σA - the "housekeeping" sigma factor or also called as primary sigma factor, ... It is homologous to archaeal transcription factor B and to eukaryotic TFIIB.[2] The specific sigma factor used to initiate ...
1) Basic domains. (1.1) Basic leucine zipper (bZIP). *Activating transcription factor *AATF ... transcription factor activity, sequence-specific DNA binding. • RNA polymerase II regulatory region sequence-specific DNA ... The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in ... regulation of transcription, DNA-templated. • negative regulation of transcription from RNA polymerase II promoter. • positive ...
1) Basic domains. (1.1) Basic leucine zipper (bZIP). *Activating transcription factor *AATF ... transcription factor binding. • protein domain specific binding. • RNA polymerase II transcription factor activity, sequence- ... Hepatocyte nuclear factor 3-gamma (HNF-3G), also known as forkhead box protein A3 (FOXA3) or transcription factor 3G (TCF-3G) ... transcription factor activity, sequence-specific DNA binding. • transcription regulatory region DNA binding. • sequence- ...
1) Basic domains. (1.1) Basic leucine zipper (bZIP). *Activating transcription factor *AATF ... transcription corepressor activity. • transcription factor activity, sequence-specific DNA binding. • transcription coactivator ... RNA polymerase II transcription factor activity, sequence-specific DNA binding. Cellular component. • nuclear euchromatin. • ... transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding. • chenodeoxycholic acid binding. • ...
1) Basic domains. (1.1) Basic leucine zipper (bZIP). *Activating transcription factor *AATF ... transcription factor regulating cell cycle progression),[25] TAL1 (a transcription factor),[26] FOG2 (a transcription factor ... also termed Erythroid transcription factor) is the founding member of the GATA family of transcription factors. This protein is ... Fujiwara T (June 2017). "GATA Transcription Factors: Basic Principles and Related Human Disorders". The Tohoku Journal of ...
1) Basic domains. (1.1) Basic leucine zipper (bZIP). *Activating transcription factor *AATF ... transcription factor activity, RNA polymerase II transcription factor recruiting. • RNA polymerase II transcription factor ... Arabidospsis thaliana MYB family at Database of Arabidopsis Transcription Factors (DATF). This article incorporates text from ... Myb proto-oncogene protein is a member of the MYB (myeloblastosis) family of transcription factors. The protein contains three ...
1) Basic domains. (1.1) Basic leucine zipper (bZIP). *Activating transcription factor *AATF ... transcription factor activity, sequence-specific DNA binding. • sequence-specific DNA binding. • transcription factor binding. ... repressing transcription factor binding. • RNA polymerase II transcription factor activity, sequence-specific DNA binding. ... transcription factor complex. • cytoplasm. • cell nucleus. • nucleoplasm. • transcriptional repressor complex. Biological ...
1) Basic domains. (1.1) Basic leucine zipper (bZIP). *Activating transcription factor *AATF ... 0001204 DNA-binding transcription factor activity. • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor ... regulation of transcription, DNA-templated. • transcription, DNA-templated. • regulation of transcription from RNA polymerase ... "Human KLF17 is a new member of the Sp/KLF family of transcription factors". Genomics. 87 (4): 474-82. doi:10.1016/j.ygeno. ...
1) Basic domains. (1.1) Basic leucine zipper (bZIP). *Activating transcription factor *AATF ... OSR1, ODD, odd-skipped related transcription factor 1, odd-skipped related transciption factor 1. ... Protein odd-skipped-related 1 is a transcription factor that in humans is encoded by the OSR1 gene.[5][6][7] The OSR1 and OSR2 ... OSR1 and OSR2 are homologous to the Odd-skipped class transcription factors in Drosophila, encoded by odd,[5] bowl, sob[9] and ...
1) Basic domains. (1.1) Basic leucine zipper (bZIP). *Activating transcription factor *AATF ... RNA polymerase II transcription factor binding. • transcription factor activity, sequence-specific DNA binding. • transcription ... domain but not a basic domain. Members of the ID family inhibit the functions of basic helix-loop-helix transcription factors ... negative regulation of sequence-specific DNA binding transcription factor activity. • regulation of transcription, DNA- ...
1) Basic domains. (1.1) Basic leucine zipper (bZIP). *Activating transcription factor *AATF ... Consisting of about 110 amino acids, the domain in winged-helix transcription factors (see Regulation of gene expression) has ... Winged-Helix+Transcription+Factors at the US National Library of Medicine Medical Subject Headings (MeSH) ... Retrieved from "https://en.wikipedia.org/w/index.php?title=Winged-helix_transcription_factors&oldid=730546101" ...
1) Basic domains. (1.1) Basic leucine zipper (bZIP). *Activating transcription factor *AATF ... MTF1, MTF-1, ZRF, metal-regulatory transcription factor 1, metal regulatory transcription factor 1. ... transcription factor activity, sequence-specific DNA binding. • transcription coactivator activity. • transcriptional activator ... transcription, DNA-templated. • positive regulation of transcription, DNA-templated. • positive regulation of transcription ...
1) Basic domains. (1.1) Basic leucine zipper (bZIP). *Activating transcription factor *AATF ... positive regulation of transcription from RNA polymerase II promoter. • transcription, DNA-templated. • transcription from RNA ... The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in ... GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific. ...
1) Basic domains. (1.1) Basic leucine zipper (bZIP). *Activating transcription factor *AATF ... transcription corepressor activity. • metal ion binding. • nucleic acid binding. • RNA polymerase II transcription factor ... DC-SCRIPT is able to repress ER and PR mediated transcription, whereas it can activate transcription mediated by RAR and PPAR. ... negative regulation of transcription from RNA polymerase II promoter. • negative regulation of intracellular estrogen receptor ...
1) Basic domains. (1.1) Basic leucine zipper (bZIP). *Activating transcription factor *AATF ... regulation of transcription, DNA-templated. • transcription, DNA-templated. • DNA geometric change. • negative regulation of B ...
Transcriptional Regulation of Metabolic Genes by the Basic Leucine Zipper Transcription Factor Hac1ip and Nutrient Stimuli ... Transcriptional Regulation of Metabolic Genes by the Basic Leucine Zipper Transcription Factor Hac1ip and Nutrient Stimuli. ... A central component of unfolded protein response pathway, the bZIP transcription factor Hac1ip, negatively regulates meiosis ... Regulation of transcription by Ume6p transcriptional regulator, Rpd3p-Sin3p histone deacetylase complex and Isw2p-Itc1p ...
Basic leucine zipper transcription factor SlbZIP1 mediates salt and drought stress tolerance in tomato.. Zhu M, Meng X, Cai J, ... Arabidopsis basic leucine zipper transcription factors involved in an abscisic acid-dependent signal transduction pathway under ... Yang O, Popova OV, Suethoff U, Lueking I, Dietz K-J, Golldack D. The Arabidopsis basic leucine zipper transcription factor ... The Arabidopsis basic leucine zipper transcription factor AtbZIP24 regulates complex transcriptional networks involved in ...
Modeling the global effect of the basic-leucine zipper transcription factor 1 (bZIP1) on nitrogen and light regulation in ... Modeling the global effect of the basic-leucine zipper transcription factor 1 (bZIP1) on nitrogen an... ... a Homedomain-Leucine Zipper I (HD-Zip I) transcription factor, is regulated by PHYTOCHROME-INTERACTING FACTOR 1 to promote ... Plant transcription factors from the homeodomain-leucine zipper family I. Role in development and stress responses by: Perotti ...
... basic Leu zipper (bZIP) transcription factors for recruitment to DNA. Here, we show that clade I bZIP transcription factors ... Clade I TGACG-Motif Binding Basic Leucine Zipper Transcription Factors Mediate BLADE-ON-PETIOLE-Dependent Regulation of ... Clade I TGACG-Motif Binding Basic Leucine Zipper Transcription Factors Mediate BLADE-ON-PETIOLE-Dependent Regulation of ... These studies expand the functional repertoire of clade I TGA factors in development and defense. ...
basic leucine zipper transcription factor, ATF-like 3. *Gene Ontology:. *Hyperlink. *Gene Summary: ... This gene encodes a member of the basic leucine zipper protein family. The encoded protein functions as a transcriptional ... The protein may play a role in repression of interleukin-2 and matrix metalloproteinase-1 transcription ...
100 µg) NRL is a basic motif-leucine zipper transcription factor that is preferentially expressed in rod photoreceptors. ...
Saccharomyces cerevisiae basic region-leucine zipper protein regulatory networks converge at the ATR1 structural gene.J. Biol. ... Regulation of the fission yeast transcription factor PAP1 by oxidative stress: requirement for the nuclear export factor Crm1 ( ... Yap1p-like transcriptions factors are distinctive due to atypical residues present in their basic DNA binding domains (15). ... The bZip Transcription Factor Cap1p Is Involved in Multidrug Resistance and Oxidative Stress Response inCandida albicans. Anne- ...
Compare basic leucine zipper ATF-like transcription factor 2 ELISA Kits from leading suppliers on Biocompare. View ... basic leucine zipper ATF-like transcription factor 2 ELISA Kits. The ELISA (enzyme-linked immunosorbent assay) is a well- ... Human Basic Leucine Zipper Transcription Factor, ATF-Like 2 (BATF2) ELISA Kit ... Your search returned 16 basic leucine zipper ATF-like transcription factor 2 ELISA ELISA Kit across 3 suppliers. ...
Antibodies for proteins involved in basic leucine zipper transcription factor pathways, according to their Panther/Gene ... Antibodies for proteins involved in basic leucine zipper transcription factor pathways; according to their Panther/Gene ...
Arabidopsis basic leucine zipper transcription factors involved in an abscisic acid-dependent signal transduction pathway under ... Arabidopsis basic leucine zipper transcription factors involved in an abscisic acid-dependent signal transduction pathway under ... Arabidopsis basic leucine zipper transcription factors involved in an abscisic acid-dependent signal transduction pathway under ... Arabidopsis basic leucine zipper transcription factors involved in an abscisic acid-dependent signal transduction pathway under ...
Basic-leucine zipper transcription factor family protein isoform 2Imported. ,p>Information which has been imported from another ... Basic-leucine zipper (BZIP) transcription factor family protein isoform 7 (Fragment). THECC ... Basic-leucine zipper (BZIP) transcription factor family protein isoform 7 (Fragment). THECC ... tr,A0A061E607,A0A061E607_THECC Basic-leucine zipper transcription factor family protein isoform 2 OS=Theobroma cacao OX=3641 GN ...
Mallappa C, Yadav V, Negi P, Chattopadhyay S (2006) A basic leucine zipper transcription factor, G-box-binding factor 1, ... The basic Leu zipper (bZIP) transcription factor family is among the largest and most diverse dimerizing transcription factor ... Genomic Survey and Gene Expression Analysis of the Basic Leucine Zipper Transcription Factor Family in Rice. Aashima Nijhawan, ... Genomic Survey and Gene Expression Analysis of the Basic Leucine Zipper Transcription Factor Family in Rice ...
Basic-Leucine Zipper Transcription Factors*Basic-Leucine Zipper Transcription Factors. *Basic Leucine Zipper Transcription ... "Basic-Leucine Zipper Transcription Factors" by people in this website by year, and whether "Basic-Leucine Zipper Transcription ... "Basic-Leucine Zipper Transcription Factors" is a descriptor in the National Library of Medicines controlled vocabulary ... Below are the most recent publications written about "Basic-Leucine Zipper Transcription Factors" by people in Profiles. ...
The Cap n Collar Basic Leucine Zipper Transcription Factor Nrf2 (NF-E2 p45-related Factor 2) Controls Both Constitutive and ... The Cap n Collar Basic Leucine Zipper Transcription Factor Nrf2 (NF-E2 p45-related Factor 2) Controls Both Constitutive and ... The Cap n Collar Basic Leucine Zipper Transcription Factor Nrf2 (NF-E2 p45-related Factor 2) Controls Both Constitutive and ... The Cap n Collar Basic Leucine Zipper Transcription Factor Nrf2 (NF-E2 p45-related Factor 2) Controls Both Constitutive and ...
The Arabidopsis Abscisic Acid Response Gene ABI5 Encodes a Basic Leucine Zipper Transcription Factor. Ruth R. Finkelstein, Tim ... The Arabidopsis Abscisic Acid Response Gene ABI5 Encodes a Basic Leucine Zipper Transcription Factor ... The Arabidopsis Abscisic Acid Response Gene ABI5 Encodes a Basic Leucine Zipper Transcription Factor ... The Arabidopsis Abscisic Acid Response Gene ABI5 Encodes a Basic Leucine Zipper Transcription Factor ...
BTB and CNC homology 1, basic leucine zipper transcription factor 1. Synonyms: 6230421P05Rik. Gene nomenclature, locus ...
The mi gene encodes a basic helix-loop-helix leucine zipper transcription factor (Mi) with tissue-restricted expression. To ... Aksan I., Goding C. R. Targeting the microphthalmia basic helix-loop-helix-leucine zipper transcription factor to a subset of E ... Expression of the Microphthalmia-associated Basic Helix-Loop-Helix Leucine Zipper Transcription Factor Miin Avian Neuroretina ... crucial dependence on the Mitf basic-helix-loop-helix-zipper transcription factor. Development (Camb.), 124: 2377-2386, 1997.. ...
... basic leucine zipper transcription factor, ATF-like stained with Rhodamine in the Antibody Database ... BATF / basic leucine zipper transcription factor, ATF-like Rhodamine Antibodies. Antibodies in the Chromocyte database for BATF ...
ATF6 (activating transcription factor 6) is a basic leucine zipper transcription factor. Upon Grp78 dissociation, the entire ... Involvement of basic leucine zipper transcription factors". The Journal of Biological Chemistry. 273 (50): 33741-9. doi:10.1074 ... is upregulated downstream of the bZIP transcription factor ATF4 (activating transcription factor 4) and uniquely responsive to ... The activated transcription factor upregulates UPR stress genes by directly binding to stress element promoters in the ...
... transcription factors perform as crucial regulators in ABA-mediated stress response in plants. Nevertheless, the functions for ... In addition, RNA-seq analysis of transgenic plants revealed that the transcription levels of multiple genes encoding defense ... Basic region/leucine zipper (bZIP) transcription factors perform as crucial regulators in ABA-mediated stress response in ... Yang O, Popova OV, Süthoff U, Lüking I, Dietz KJ, Golldack D. The Arabidopsis basic leucine zipper transcription factor ...
Erratum: The basic leucine zipper transcription factor E4BP4 is essential for natural killer cell development ... Erratum: The basic leucine zipper transcription factor E4BP4 is essential for natural killer cell development ... Erratum: The basic leucine zipper transcription factor E4BP4 is essential for natural killer cell development ... Oxford scientists discover key factor that alerts stem cells to accelerate healing of multiple tissues ...
The basic region/leucine zipper (bZIP) transcription factors have a basic region that binds DNA and a leucine zipper for homo- ... 3. Basic Leucine-Zipper Transcription Factors. Transcription factors play crucial roles in almost all biological processes and ... ii) Target genes and the post-translational regulation of the Arabidopsis subclass C basic leucine-zipper (bZIP) transcription ... The basic domain contacts the DNA, whereas the leucine zipper mediates protein dimerization (source: www.icm.edu.pl). ...
PPI1 : a novel pathogen-induced basic region-leucine zipper (bZIP) transcription factor from pepper. ... We have isolated a full-length cDNA, PPI1 (pepper-PMMV interaction 1), encoding a novel basic region-leucine zipper (bZIP) DNA- ... Our data provide the first evidence that a bZIP transcription factor is preferentially induced by pathogen attack, suggesting ... leucine zippers; molecular sequence data; plant diseases. ...
Maf proteins belong to the AP1 superfamily of basic region-leucine zipper (bZIP) transcription factors. Residues in the basic ... Maf proteins belong to the AP1 superfamily of basic region-leucine zipper (bZIP) transcription factors. Residues in the basic ... to the MITF gene that encodes a transcription factor with a basic-helix-loop-helix-leucine zipper (bHLH-Zip) motif and that is ... A transcription interference assay was used to generate mutant basic region-leucine zipper proteins with altered DNA-binding ...
basic leucine zipper ATF-like transcription factor 2. MGC20410. 11q13.1. BATF3 basic leucine zipper ATF-like transcription ... basic leucine zipper ATF-like transcription factor. B-ATF, SFA-2, BATF1. 14q24.3. ... activating transcription factor 1. TREB36. 12q13.12. ATF2 activating transcription factor 2. CREB2. TREB7, CRE-BP1, HB16. ... FOS like 1, AP-1 transcription factor subunit. fra-1. 11q13.1. FOSL2 FOS like 2, AP-1 transcription factor subunit. FRA2, ...
Basic Leucine Zipper ATF-Like Transcription Factor 3, including: function, proteins, disorders, pathways, orthologs, and ... BATF3 (Basic Leucine Zipper ATF-Like Transcription Factor 3) is a Protein Coding gene. Among its related pathways are ... Basic Leucine Zipper Transcriptional Factor ATF-Like 3 3 4 * Basic Leucine Zipper Transcription Factor, ATF-Like 3 2 3 ... Repression of IL-2 promoter activity by the novel basic leucine zipper p21SNFT protein. (PMID: 10878360) Iacobelli M … McGuire ...
Basic Leucine Zipper ATF-Like Transcription Factor 2, including: function, proteins, disorders, pathways, orthologs, and ... basic leucine zipper transcription factor, ATF-like 2 [30-313]. *Basic leucine zipper transcriptional factor ATF-like 2 [59-251 ... basic leucine zipper transcription factor, ATF-like 2 [30-313]. *Basic leucine zipper transcriptional factor ATF-like 2 [59-251 ... BATF2 (Basic Leucine Zipper ATF-Like Transcription Factor 2) is a Protein Coding gene. Diseases associated with BATF2 include ...
The basic leucine zipper transcription factors characteristically form heterodimers through their leucine zippers with the ... Bach2 basics. Bach2 is a member of the Bach family of basic leucine zipper transcription factors (Fig. 1A). The Bach2 gene is ... Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate ... Broad complex-tamtrack-bric-a-brac (BTB) region, basic region, and leucine zipper are depicted. (B) DNA binding motif for Bach2 ...
The basic leucine zipper transcription factor ABSCISIC ACID RESPONSE ELEMENT-BINDING FACTOR2 is an important transcriptional ... The basic leucine zipper transcription factor ABSCISIC ACID RESPONSE ELEMENT-BINDING FACTOR2 is an important transcriptional ... The basic leucine zipper transcription factor ABSCISIC ACID RESPONSE ELEMENT-BINDING FACTOR2 is an important transcriptional ...
The transcriptional programs that guide lymphocyte differentiation depend on the precise expression and timing of transcription ... factors (TFs). The TF BACH2 is essential for T and B lymphocytes and is associated with an archetypal super-enhancer (SE). ... Basic-Leucine Zipper Transcription Factors Grant support * MC_U120061454/MRC_/Medical Research Council/United Kingdom ... programs that guide lymphocyte differentiation depend on the precise expression and timing of transcription factors (TFs). The ...
Basic-Leucine Zipper Transcription Factors * DNA-Binding Proteins * G-Box Binding Factors ...
... and by the B3 domain transcription factor abscisic acid insensitive 3 (ABI3). The in vivo role of bZIP53 is further supported ... and by the B3 domain transcription factor abscisic acid insensitive 3 (ABI3). The in vivo role of bZIP53 is further supported ... The SDH2.3 promoter is activated in leaf protoplasts by heterodimers between the basic leucine zipper transcription factors ... The SDH2.3 promoter is activated in leaf protoplasts by heterodimers between the basic leucine zipper transcription factors ...
Involvement of basic leucine zipper transcription factors. J. Biol. Chem. 273, 33741-33749. doi: 10.1074/jbc.273.50.33741 ... This encodes a highly active transcription factor (XBP1s) which is able to induce transcription of selected genes by binding ... factor was induced by XBP1(s) the transcription factor resulted following IRE1 activation (Calfon et al., 2002). Since XBP1(s) ... Nishitoh, H. (2012). CHOP is a multifunctional transcription factor in the ER stress response. J. Biochem. 151, 217-219. doi: ...
  • AtbZIP24 encodes a bZIP transcription factor that is induced by salt stress in Ambidopsis thaliana but suppressed in the salt-tolerant relative Lobularia maritima. (uni-bielefeld.de)
  • This gene encodes a protein highly homologous to the S. cerevisiae bZip transcription factor Yap1p and was named CAP1 , for C. albicans AP-1. (asm.org)
  • The modification of transcriptional control by regulatory transcription factors provides a useful strategy for improving salt tolerance in plants. (uni-bielefeld.de)
  • Yang O, Popova OV, Suethoff U, Lueking I, Dietz K-J, Golldack D. The Arabidopsis basic leucine zipper transcription factor AtbZIP24 regulates complex transcriptional networks involved in abiotic stress resistance. (uni-bielefeld.de)
  • The Arabidopsis basic leucine zipper transcription factor AtbZIP24 regulates complex transcriptional networks involved in abiotic stress resistance", GENE , vol. 436, 2009, pp. 45-55. (uni-bielefeld.de)
  • Here, we show that clade I bZIP transcription factors TGA1 and TGA4, previously associated with plant defense, are essential cofactors in BOP-dependent regulation of development. (carleton.ca)
  • Members of this family lack a DNA-binding domain and interact with TGACG-motif binding (TGA) basic Leu zipper (bZIP) transcription factors for recruitment to DNA. (carleton.ca)
  • These studies expand the functional repertoire of clade I TGA factors in development and defense. (carleton.ca)
  • Here, we evaluate the role of bZIP1, a transcription factor involved in light and nitrogen sensing, by exposing wild-type (WT) and bZIP1 T-DNA null mutant plants to a combinatorial space of nitrogen (N) and light (L) treatment conditions and performing transcriptome analysis. (gob.ar)
  • Three cDNAs encoding basic leucine zipper (bZIP)-type ABRE-binding proteins were isolated by using the yeast one-hybrid system and were designated AREB1, AREB2, and AREB3 (ABA-responsive element binding protein). (pnas.org)
  • A cDNA for the ABRE-binding protein EmBP-1 was first shown to encode a basic leucine zipper (bZIP) protein containing a basic DNA-binding domain linked to a leucine zipper domain ( 4 ). (pnas.org)
  • A central component of unfolded protein response pathway, the bZIP transcription factor Hac1ip, negatively regulates meiosis and pseudohyphal growth. (dur.ac.uk)
  • We have isolated a full-length cDNA, PPI1 (pepper-PMMV interaction 1), encoding a novel basic region-leucine zipper (bZIP) DNA-binding protein, from expressed sequence tags differentially expressed in Capsicum chinense PI257284 infected with Pepper mild mottle virus (PMMV). (kribb.re.kr)
  • This gene encodes a member of the basic leucine zipper protein family. (genecards.org)
  • The protein may play a role in repression of interleukin-2 and matrix metalloproteinase-1 transcription. (genecards.org)
  • BATF3 (Basic Leucine Zipper ATF-Like Transcription Factor 3) is a Protein Coding gene. (genecards.org)
  • Transmembrane glycoprotein of the endoplasmic reticulum that functions as a transcription activator and initiates the unfolded protein response (UPR) during endoplasmic reticulum stress. (uniprot.org)
  • AhAREB1 ( Arachis hypogaea Abscisic-acid Response Element Binding Protein 1) is a member of the basic domain leucine zipper (bZIP)-type transcription factor in peanut. (mdpi.com)
  • Further experiments demonstrated that the PCV2 ORF5 protein induces ERS and UPR via the PERK (RNA-activated protein kinase-like endoplasmic reticulum kinase), ATF6 (activating transcription factor 6) and IRE1 (inositol requiring enzyme 1) signaling pathways. (springer.com)
  • Cheung AK (2003) The essential and nonessential transcription units for viral protein synthesis and DNA replication of porcine circovirus type 2. (springer.com)
  • When Hac1 is efficiently translated, it binds to the unfolded protein response element in the promoters of ER chaperones and other UPR targets and up-regulates their transcription ( 5 , 16 , 22 , 24 ). (asm.org)
  • Eukaryotic cells respond to the presence of unfolded proteins by upregulating the transcription of genes encoding ER resident protein chaperones such as the glucose-regulated BiP/Grp78 and Grp94 that assist in protein folding ( 16 , 17 ). (asm.org)
  • Only the spliced form of the XBP-1s protein is an active transcription factor, while XBP-1u has no transactivation ability ( 14 , 64 ). (asm.org)
  • Further, we find that ectopic expression of UL148 is sufficient to activate at least two UPR sensors: the inositol-requiring enzyme-1 (IRE1), as indicated by splicing of Xbp-1 mRNA, and the protein kinase R (PKR)-like ER kinase (PERK), as indicated by phosphorylation of the α subunit of eukaryotic initiation factor 2 (eIF2α) and accumulation of activating transcription factor 4 (ATF4). (asm.org)
  • It is activated by PROTEASES and then moves to the CELL NUCLEUS to regulate GENETIC TRANSCRIPTION of GENES involved in the unfolded protein response. (harvard.edu)
  • Basic information about the protein. (yeastgenome.org)
  • Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a tr. (nih.gov)
  • The role of cleaved activating transcription factor 6α (ΔATF6α) and spliced X-box protein-1 (sXBP1) in PRNP gene expression was assessed with over-expression or silencing techniques. (biomedcentral.com)
  • The protein encoded by this gene is a basic leucine zipper transcription factor that plays an important role in the regulation of lineage-specific hematopoiesis. (thermofisher.com)
  • The encoded nuclear protein represses ETS1-mediated transcription of erythroid-specific genes in myeloid cells. (thermofisher.com)
  • Alonso R, Onate-Sanchez L, Weltmeier F, Ehlert A, Diaz I, Dietrich K, Vicente-Carbajosa J, Droge-Laser W (2009) A pivotal role of the basic leucine zipper transcription factor bZIP53 in the regulation of Arabidopsis seed maturation gene expression based on heterodimerization and protein complex formation. (springer.com)
  • Ehlert A, Weltmeier F, Wang X, Mayer CS, Smeekens S, Vicente-Carbajosa J, Droge-Laser W (2006) Two-hybrid protein-protein interaction analysis in Arabidopsis protoplasts: establishment of a heterodimerization map of group-C and S bZIP transcription factors. (springer.com)
  • The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. (wikiversity.org)
  • The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs and is involved in regulating multiple cellular processes. (wikiversity.org)
  • explored why nearly all of the transcription factor MondoA and its binding partner protein called Mlx is found in the cytoplasm but the protein appears to function as a transcription factor in the nucleus. (sciencemag.org)
  • Objective The basic leucine zipper transcription factor, ATF-like (BATF), a member of the Activator protein-1 family, promotes transcriptional activation or repression, depending on the interacting partners (JUN-B or C-JUN). (bmj.com)
  • 5 Activator protein-1 (AP-1) forms homodimers and heterodimers composed of JUN and FOS family members, which act as either oncogenic or tumour suppressor factors, depending on the specific dimer compositions. (bmj.com)
  • Basic leucine zipper transcription factor, ATF-like , also known as BATF , is a protein which in humans is encoded by the BATF gene . (wikidoc.org)
  • The protein encoded by this gene is a nuclear basic leucine zipper ( bZIP ) protein that belongs to the AP-1 / ATF superfamily of transcription factors . (wikidoc.org)
  • The leucine zipper of this protein mediates dimerization with members of the Jun family of proteins. (wikidoc.org)
  • Owing to the stability of their coiled coil structure leucine zipper (LZ) domains of bZIP factors are widely employed as dimerization motifs in protein engineering studies. (jove.com)
  • The leucine zipper moiety of the human factor c-Jun as well as the entire c-Jun protein are also shown to catalyze degradation of RNA. (jove.com)
  • Briefly, the integral membrane bait protein is fused to C ub which is linked to an artificial transcription factor. (jove.com)
  • a protein that binds to specific DNA sequences, thereby controlling the flow (or transcription) of genetic information from DNA to mRNA is called a transcription factor . (wikiversity.org)
  • At the level of the protein, the mutation exchanges a serine with a leucine residue at a position on MAFB that can become phosphorylated in the wild-type protein. (smw.ch)
  • The MAF proteins belong to the activator protein-1 (AP1) superfamily of transcription factors, which are known to form homo- and heterodimers via an extended leucine zipper [ 6 ]. (smw.ch)
  • The basic domain that precedes this leucine zipper enables the interaction of the protein with the MAF recognition element (MARE) on target genes. (smw.ch)
  • Subsequently, ATF4 co-occupies promoter regions of over 30 MYC-target genes, primarily those regulating amino acid and protein synthesis, including eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1), a negative regulator of translation. (stanford.edu)
  • 1993 ) Erythroid transcription factor NF-E2 is a haematopoietic-specific basic-leucine zipper protein. (biologists.org)
  • 1989 ) The erythroid-specific transcription factor Eryf1: a new finger protein. (biologists.org)
  • In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. (wikipedia.org)
  • The maize VP1 and Arabidopsis ABI3 genes play key roles in ABA-dependent seed maturation, and both genes encode seed-specific, homologous transcription factors that mediate ABA-regulated gene expression in seeds ( 10 , 11 ). (pnas.org)
  • ii) Target genes and the post-translational regulation of the Arabidopsis subclass C basic leucine-zipper (bZIP) transcription factors and the analysis of their function in plant growth and development. (uni-tuebingen.de)
  • Yang O, Popova OV, Suethoff U, Lueking I, Dietz K-J, Golldack D. The Arabidopsis basic leucine zipper transcription factor AtbZIP24 regulates complex transcriptional networks involved in abiotic stress resistance. (uni-bielefeld.de)
  • The Arabidopsis basic leucine zipper transcription factor AtbZIP24 regulates complex transcriptional networks involved in abiotic stress resistance", GENE , vol. 436, 2009, pp. 45-55. (uni-bielefeld.de)
  • SA-inducible Arabidopsis glutaredoxin interacts with TGA factors and suppresses JA-responsive PDF1.2 transcription. (semanticscholar.org)
  • A novel wheat bZIP transcription factor, TabZIP60, confers multiple abiotic stress tolerances in transgenic Arabidopsis. (semanticscholar.org)
  • Here, we isolated AtbZIP1 , and used semi-quantitative reverse transcription-PCR to verify that AtbZIP1 expression was indeed significantly induced by salt, osmotic, and cold stresses in Arabidopsis. (springer.com)
  • We previously identified four Arabidopsis auxin-inducible Lateral Organ Boundaries Domain (LBD) transcription factors that govern callus formation. (nature.com)
  • Here, we report that Arabidopsis basic region/leucine zipper motif 59 (AtbZIP59) transcription factor forms complexes with LBDs to direct auxin-induced callus formation. (nature.com)
  • Identification of a novel bZIP transcription factor in Camellia sinensis as a negative regulator of freezing tolerance in transgenic arabidopsis. (bioportfolio.com)
  • Expression of the Microphthalmia-associated Basic Helix-Loop-Helix Leucine Zipper Transcription Factor Miin Avian Neuroretina Cells Induces aPigmented Phenotype -- Planque et al. (aacrjournals.org)
  • The MITF gene encodes a transcription factor containing a basic-helix-loop-helix-leucine zipper. (medscape.com)
  • 1997) have demonstrated that the Tyrosinase initiator E box and M box elements are targets for the microphthalmia-associated basic helix-loop-helix-leucine zipper (bHLH-LZ) transcription factor Mitf (Hodgkinson et al. (wikiversity.org)
  • This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. (wikiversity.org)
  • What's a transcription factor of the basic helix-loop-helix leucine zipper family doing in the cytoplasm? (sciencemag.org)
  • MyoD belongs to a small family of basic helix-loop-helix transcription factors implicated in skeletal muscle lineage determination and differentiation. (biologists.org)
  • We have investigated here the contribution of the UPR transcription factors XBP-1, ATF6α, and ATF6β to UPR target gene expression. (asm.org)
  • The second ER transmembrane component of the mammalian UPR is a basic region/leucine zipper transcription factor called ATF6α that is constitutively expressed in an inactive form in the membrane of the ER. (asm.org)
  • ATF6 is an endoplasmic reticulum (ER) stress-regulated transmembrane transcription factor that activates the transcription of ER molecules. (wikidoc.org)
  • The cytosolic portion of ATF6 will move to the nucleus and act as a transcription factor to cause the transcription of ER chaperones. (wikidoc.org)
  • ATF6 has been shown to interact with YY1 [5] and Serum response factor . (wikidoc.org)
  • Northern blotting has shown that mouse small intestine contains relatively large amounts of the nuclear factor-E2 p45-related factor (Nrf) 2 transcription factor but relatively little Nrf1. (aacrjournals.org)
  • p21SNFT (21 kDa small nuclear factor isolated from T cells) is a human basic leucine zipper transcription factor that can repress AP-1-mediated transcription. (biomedsearch.com)
  • In addition, nuclear factor erythroid 2-related factor 2 (Nrf2) plays a key role in the cellular response to oxidative stress. (hindawi.com)
  • Nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant-responsive element (ARE) pathway is proven to be crucial in this process [ 5 , 6 ]. (hindawi.com)
  • After screening 3000 methanolic extracts from the Formosan plant extract bank, Excoecaria formosana showed glycine N -methyltransferase (GNMT)-promoter-enhancing and nuclear factor erythroid 2-related factor 2 (NRF2)-suppressing activities. (mdpi.com)
  • Their expression is regulated by several transcription factors and/or cofactors like nuclear factor-erythroid 2 (NF-E2) related factor 2 (Nrf2) and peroxisome proliferator-activated receptor- γ coactivator 1 α (PGC-1 α ). (hindawi.com)
  • Subsequently, we discuss the role of transcription factors nuclear factor (erythroid-derived 2)-like 2 (Nrf2), Myocyte enhancer factor 2 (MEF2), and Forkhead box (FOXO) and their associated posttranslational modifications as it pertains to regulating each of these networks. (degruyter.com)
  • 1989 ) Identification of a myocyte nuclear factor that binds to the muscle-specific enhancer of the mouse muscle creatine kinase gene. (biologists.org)
  • One part of the domain contains a region that mediates sequence specific DNA binding properties and the leucine zipper that is required to hold together (dimerize) two DNA binding regions. (genenames.org)
  • AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells. (abcam.com)
  • The basic region consists of about 16 amino acid residues characterized by the presence of an invariant N-x 7 -R/K motif, whereas the Leu zipper is composed of heptad repeats of Leu or other bulky hydrophobic amino acids (Ile, Val, Phe, or Met) positioned exactly nine amino acids toward the C terminus. (plantphysiol.org)
  • A large superfamily of transcription factors that contain a region rich in BASIC AMINO ACID residues followed by a LEUCINE ZIPPER domain. (umassmed.edu)
  • Although Bach2 has a well-described role in B cell differentiation, emerging data show that Bach2 is a prototypical member of a novel class of transcription factors that regulates transcriptional activity in T cells at super-enhancers, or regions of high transcriptional activity. (jimmunol.org)
  • Bach2 is a member of the Bach family of basic leucine zipper transcription factors ( Fig. 1A ). (jimmunol.org)
  • Several factors regulate Bach2 activity and localization (reviewed in Ref. 2 ), including PI3K signaling in B cells, which leads to phosphorylation of Ser 512 and cytosolic accumulation. (jimmunol.org)
  • We found that heme bound to Bach2, a transcription factor essential for humoral immunity, including antibody class switch. (bloodjournal.org)
  • Bach1 and Bach2 constitute a subfamily of the basic region-leucine zipper (bZip) family. (bloodjournal.org)
  • The B cell-specific transcription factor BACH2 is required for affinity maturation of B cells. (nature.com)
  • Regulation of intestinal antioxidant and detoxication enzymes by Nrf2 has been assessed using a mouse line bearing a targeted disruption of the gene encoding this factor. (aacrjournals.org)
  • Regulation of transcription by Ume6p transcriptional regulator, Rpd3p-Sin3p histone deacetylase complex and Isw2p-Itc1p chromatin remodelling complex at URS1 was also investigated here. (dur.ac.uk)
  • Here, we show that clade I bZIP transcription factors TGA1 and TGA4, previously associated with plant defense, are essential cofactors in BOP-dependent regulation of development. (carleton.ca)
  • Further, the previously reported ability of geldanamycin to stimulate ER stress-dependent transcription apparently depends on its interaction with GRP94, not HSP90, since geldanamycin but not 514 led to up-regulation of BiP. (asm.org)
  • Hence, the combinatorial use of a subset of the approximately 2000 human transcription factors easily accounts for the unique regulation of each gene in the human genome during development. (wikiversity.org)
  • The negative regulation is accomplished by inhibiting RANKL-mediated osteoclastogenesis at the transcriptional level via binding to transcription factors FOS and MITF. (smw.ch)
  • GATA-1 is a zinc-finger transcription factor believed to play an important role in gene regulation during the development of erythroid cells, megakaryocytes and mast cells. (biologists.org)
  • Transcription factors are essential for the regulation of gene expression and are, as a consequence, found in all living organisms. (wikipedia.org)
  • Transcription factors use a variety of mechanisms for the regulation of gene expression. (wikipedia.org)
  • We isolated the ABI5 gene by using a positional cloning approach and found that it encodes a member of the basic leucine zipper transcription factor family. (plantcell.org)
  • AtbZIP24 encodes a bZIP transcription factor that is induced by salt stress in Ambidopsis thaliana but suppressed in the salt-tolerant relative Lobularia maritima. (uni-bielefeld.de)
  • The PAX3 gene encodes a transcription factor with a paired box domain, an octapeptide domain, and a homeobox domain essential for survival of melanocytes during development. (medscape.com)
  • 1 In addition to these well-established functions as a prosthetic group, recent reports have revealed that heme regulates several transcription factors, including Bach1, 2 ⇓ ⇓ - 5 NPAS2, 6 and REV-ERBs, 7 and modulates gene expression as an inter- and intracellular signaling molecule in mammals. (bloodjournal.org)
  • bZIP transcription factors owe their name to their highly conserved bZIP domain composed of a basic region and a Leu zipper ( Hurst, 1994 ). (plantphysiol.org)
  • Basic Leucine Zipper Transcription Factor ATF-Like 3 (BATF3) which is localizes to the nucleus, contains 1 bZIP domain. (prospecbio.com)
  • By next-generation sequencing, the authors identified ten different missense mutations in the gene for the transcription factor MAFB. (smw.ch)
  • MAFB is a member of the MAF family of basic leucine zipper transcription factors [ 4 , 5 ]. (smw.ch)
  • To unravel the molecular basis of such coupled preferences, we determined two high-resolution structures of the transcription factor MafB as a homodimer and as a heterodimer with c-Fos bound to variants of the Maf-recognition element. (rcsb.org)
  • Among its related pathways are Preimplantation Embryo and Calcineurin-regulated NFAT-dependent transcription in lymphocytes . (genecards.org)
  • Our data provide a concept for transcription factor design to selectively activate dimer-specific pathways and binding repertoires. (rcsb.org)
  • Their chromosomal distribution and sequence analyses suggest that the bZIP transcription factor family has evolved via gene duplication. (plantphysiol.org)
  • The basic region is responsible for sequence-specific DNA binding and is highly conserved. (plantphysiol.org)
  • The Leu zipper is an amphipathic sequence in the form of coiled-coil, which confers dimerization specificity and is less conserved. (plantphysiol.org)
  • Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding . (genecards.org)
  • Sequence analysis shows that AtbZIP1 belongs to the S subfamily of basic leucine zipper transcription factors (TFs). (springer.com)
  • Once the DNA double helix and its associated epigenome have been melted so that the template strand is available for binding, a transcription factor binds to a specific nucleotide sequence to biochemically influence gene transcription . (wikiversity.org)
  • a substance that contains one or more DNA-binding domains that are nucleotide-sequence specific is called a transcription factor . (wikiversity.org)
  • In current review, we discussed and summarized the therapeutic effects of Nrf2 activation on DN from both basic and clinical studies. (hindawi.com)
  • Furthermore, Nrf2 is a vital transcription factor that protects against the cytotoxic effects of both oxidant and electrophile stress. (mdpi.com)
  • The transcription factor E4bp4 (Nfil3) is essential for natural killer (NK) cell production. (rupress.org)
  • To elucidate the mechanism by which E4bp4 promotes NK development, we identified a central core of transcription factors that can rescue NK production from E4bp4 −/− progenitors, suggesting that they act downstream of E4bp4. (rupress.org)
  • E4bp4 binds directly to the regulatory regions of both Eomes and Id2, promoting their transcription. (rupress.org)
  • We propose that E4bp4 is required for commitment to the NK lineage and promotes NK development by directly regulating the expression of the downstream transcription factors Eomes and Id2. (rupress.org)
  • Therefore, E4bp4 is a good candidate for a factor required at the NK lineage commitment point, and we might expect to find a network of transcription factors downstream of E4bp4. (rupress.org)
  • Here, we show that E4bp4 is essential for the development of NK-committed progenitor cells from CLPs and identify several transcription factors, notably Eomes and Id2, that act downstream of it. (rupress.org)
  • The transcriptional programs that guide lymphocyte differentiation depend on the precise expression and timing of transcription factors (TFs). (nih.gov)
  • Previous work has shown that under FR light conditions the transcription factor PHYOCHROME-INTERACTING-FACTOR1 (PIF1) accumulates and promotes expression of SOMNUS ( SOM ) that, in turn, leads to increased ABA and decreased GA levels. (pnas.org)
  • Here we show that MFT gene expression is promoted by FR light through the PIF1/SOM/ABI5/DELLA pathway and is repressed by R light via the transcription factor SPATULA (SPT). (pnas.org)
  • ER stress was a positive regulator of PRNP gene transcription in MCF-7 cells and luciferase reporter assays identified one ER stress response element (ERSE) conserved among primates and rodents and three primate-specific ERSEs that regulated PRNP gene expression. (biomedcentral.com)
  • This adaptive response often requires upregulation of endogenous antioxidant enzymes, and their expression levels can be regulated by several transcription factors. (hindawi.com)
  • Data indicte that interferon regulatory factor 8 (IRF8 (show IRF8 ELISA Kits )) expression becomes dependent on transcription factor Batf3 . (antibodies-online.com)
  • Various extracellular stimuli promote the formation of unique dimeric transcription factor complexes that play pivotal roles in gene regulatory flexibility and enhance their DNA-binding specificity to facilitate tight control of gene expression. (bmj.com)
  • This molecule is in turn recognized by cytosolic deubiquitinating enzymes, resulting in cleavage of the transcription factor, and subsequent induction of reporter gene expression. (jove.com)
  • Expression of ATF3 (activating transcription factor 3) is induced by a variety of environmental stress conditions, including nutrient limitation. (biochemj.org)
  • 1990 ) Progressive inactivation of the expression of an erythroid transcriptional factor in GM-and G-CSF-dependent myeloid cell lines. (biologists.org)
  • In transgenic mice, this enhancer directs expression of a lacZ reporter gene to skeletal muscle compartments in a spatiotemporal pattern indistinguishable from the normal myoD expression domain, and distinct from expression patterns reported for the other myogenic factors. (biologists.org)
  • The ability of basic leucine zipper transcription factors for homo- or heterodimerization provides a paradigm for combinatorial control of eukaryotic gene expression. (rcsb.org)
  • Ig gene rearrangement steps are initiated in early human precursor B cell subsets and correlate with specific transcription factor expression. (nature.com)
  • Members of this family lack a DNA-binding domain and interact with TGACG-motif binding (TGA) basic Leu zipper (bZIP) transcription factors for recruitment to DNA. (carleton.ca)
  • The DNA binding region comprises a number of basic amino acids such as arginine and lysine. (genenames.org)
  • These latter changes closely paralleled the initial increase in RNA pol II (RNA polymerase II) binding to the promoter and in the transcription rate from the ATF3 gene. (biochemj.org)
  • Many of these GTFs do not actually bind DNA, but rather are part of the large transcription preinitiation complex that interacts with RNA polymerase directly. (wikipedia.org)
  • Play important roles in coordinating transcription activation and repression by MAFK. (abcam.com)
  • Previously, we reported that GATA-1- mutant cells failed to contribute to the mature red blood cell population, indicating a requirement for this factor at some point in the erythroid lineage (L. Pevny et al. (biologists.org)
  • Thus, the mast and megakaryocyte lineages, in which GATA-1 and GATA-2 are co-expressed, can complete their maturation in the absence of GATA-1, while erythroid cells, in which GATA-1 is the predominant GATA factor, are blocked at a relatively early stage of maturation. (biologists.org)
  • Basic-Leucine Zipper Transcription Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • This in turn is thought to activate an adjacent endoribonuclease activity in the C terminus of Ire1p that excises a translation-inhibitory intron from the mRNA encoding the transcription factor Hac1. (asm.org)
  • The "UV response is mediated by the ubiquitous bHLH-LZ transcription factor [upstream stimulatory factor] Usf-1, which, like Mitf, binds the conserved E box elements in the Tyrosinase promoter. (wikiversity.org)
  • Comparing the known maf structures, we propose that DNA binding specificity results from positioning the basic helix through unique phosphate contacts. (osti.gov)
  • When added to B-cell primary cultures, heme enhanced the transcription of Blimp-1, the master regulator of plasma cells, and skewed plasma cell differentiation toward the IgM isotype, decreasing the IgG levels in vitro. (bloodjournal.org)
  • BATF3 functions as a negative regulator of AP-1-mediated transcription when interacting with c-Jun, particularly by heterodimerizing with c-Jun and binding to DNA response elements. (prospecbio.com)
  • Selectively suppresses CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CCN1 and inhibits CCN1-induced anchorage-independent growth and invasion in several cancer types, such as breast cancer, malignant glioma and metastatic melanoma. (genecards.org)
  • 1990 ) Myf-6 , a new member of the human gene family of myogenic determination factors: evidence for a gene cluster on chromosome 12. (biologists.org)
  • This graph shows the total number of publications written about "Activating Transcription Factor 6" by people in Harvard Catalyst Profiles by year, and whether "Activating Transcription Factor 6" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Activating Transcription Factor 6" by people in Profiles. (harvard.edu)
  • Waterlogging (WL) is a key factor hindering soybean crop productivity worldwide. (biomedcentral.com)
  • AP-1 family transcription factor that controls the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. (genecards.org)
  • AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. (genecards.org)
  • The transcription factor Batf3 inhibits the differentiation of regulatory T cells in the periphery. (antibodies-online.com)
  • Batf3 acts as a fate-decision factor with respect to Tconv versus Tregs by restraining Treg differentiation. (antibodies-online.com)
  • In the present study, we demonstrate that the increase in ATF3 mRNA content following amino acid limitation of human HepG2 hepatoma cells is dependent on transcriptional activation of the ATF3 gene, through a highly co-ordinated amino acid-responsive programme of transcription factor synthesis and action. (biochemj.org)
  • Promoter analysis showed that a C/EBP-ATF composite site at −23 to −15 bp relative to the transcription start site of the ATF3 gene functions as an AARE (amino acid response element). (biochemj.org)
  • The increase in ATF3 and C/EBPβ binding was considerably slower and more closely correlated with a decline in transcription rate. (biochemj.org)
  • The SDH2.3 promoter is activated in leaf protoplasts by heterodimers between the basic leucine zipper transcription factors bZIP53 (group S1) and bZIP10 (group C) acting through the ABRE elements, and by the B3 domain transcription factor ABA insensitive 3 (ABI3). (frontiersin.org)
  • The modification of transcriptional control by regulatory transcription factors provides a useful strategy for improving salt tolerance in plants. (uni-bielefeld.de)
  • 1993 ) Separable regulatory elements governing myogenin transcription in mouse embryogenesis. (biologists.org)
  • Interestingly, extracts from myoblasts and 10T1/2 fibroblasts yield identical protection profiles, indicating a similar complement of enhancer-binding factors in muscle and this non-muscle cell type. (biologists.org)