Leucine Zippers: DNA-binding motifs formed from two alpha-helixes which intertwine for about eight turns into a coiled coil and then bifurcate to form Y shaped structures. Leucines occurring in heptad repeats end up on the same sides of the helixes and are adjacent to each other in the stem of the Y (the "zipper" region). The DNA-binding residues are located in the bifurcated region of the Y.Basic-Leucine Zipper Transcription Factors: A large superfamily of transcription factors that contain a region rich in BASIC AMINO ACID residues followed by a LEUCINE ZIPPER domain.Transcription Factors: Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.NF-E2-Related Factor 2: A basic-leucine zipper transcription factor that was originally described as a transcriptional regulator controlling expression of the BETA-GLOBIN gene. It may regulate the expression of a wide variety of genes that play a role in protecting cells from oxidative damage.Abscisic Acid: Abscission-accelerating plant growth substance isolated from young cotton fruit, leaves of sycamore, birch, and other plants, and from potatoes, lemons, avocados, and other fruits.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Transcription, Genetic: The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.DNA-Binding Proteins: Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.Promoter Regions, Genetic: DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.G-Box Binding Factors: A family of transcription factors found primarily in PLANTS that bind to the G-box DNA sequence CACGTG or to a consensus sequence CANNTG.Proto-Oncogene Proteins c-maf: Maf proto-oncogene protein is the major cellular homolog of the V-MAF ONCOGENE PROTEIN. It was the first of the mammalian MAF TRANSCRIPTION FACTORS identified, and it is induced in activated T-LYMPHOCYTES and regulates GENETIC TRANSCRIPTION of INTERLEUKIN-4. c-maf is frequently translocated to an immunoglobulin locus in MULTIPLE MYELOMA.Basic Helix-Loop-Helix Leucine Zipper Transcription Factors: A family of transcription factors that contain regions rich in basic residues, LEUCINE ZIPPER domains, and HELIX-LOOP-HELIX MOTIFS.Gene Expression Regulation, Plant: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in plants.Plant Proteins: Proteins found in plants (flowers, herbs, shrubs, trees, etc.). The concept does not include proteins found in vegetables for which VEGETABLE PROTEINS is available.Arabidopsis: A plant genus of the family BRASSICACEAE that contains ARABIDOPSIS PROTEINS and MADS DOMAIN PROTEINS. The species A. thaliana is used for experiments in classical plant genetics as well as molecular genetic studies in plant physiology, biochemistry, and development.Microphthalmia-Associated Transcription Factor: A basic helix-loop-helix leucine zipper transcription factor that regulates the CELL DIFFERENTIATION and development of a variety of cell types including MELANOCYTES; OSTEOCLASTS; and RETINAL PIGMENT EPITHELIUM. Mutations in MITF protein have been associated with OSTEOPETROSIS and WAARDENBURG SYNDROME.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.CCAAT-Enhancer-Binding Protein-beta: A CCAAT-enhancer-binding protein found in LIVER; INTESTINES; LUNG and ADIPOSE TISSUE. It is an important mediator of INTERLEUKIN-6 signaling.Trans-Activators: Diffusible gene products that act on homologous or heterologous molecules of viral or cellular DNA to regulate the expression of proteins.Arabidopsis Proteins: Proteins that originate from plants species belonging to the genus ARABIDOPSIS. The most intensely studied species of Arabidopsis, Arabidopsis thaliana, is commonly used in laboratory experiments.Gene Expression Regulation: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.Binding Sites: The parts of a macromolecule that directly participate in its specific combination with another molecule.Protein Binding: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.Sequence Homology, Amino Acid: The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.Plants, Genetically Modified: PLANTS, or their progeny, whose GENOME has been altered by GENETIC ENGINEERING.Response Elements: Nucleotide sequences, usually upstream, which are recognized by specific regulatory transcription factors, thereby causing gene response to various regulatory agents. These elements may be found in both promoter and enhancer regions.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Seeds: The encapsulated embryos of flowering plants. They are used as is or for animal feed because of the high content of concentrated nutrients like starches, proteins, and fats. Rapeseed, cottonseed, and sunflower seed are also produced for the oils (fats) they yield.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Transcriptional Activation: Processes that stimulate the GENETIC TRANSCRIPTION of a gene or set of genes.Maf Transcription Factors, Large: A family of high molecular weight Maf transcription factors that contain distinct activation domains.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Helix-Loop-Helix Motifs: Recurring supersecondary structures characterized by 20 amino acids folding into two alpha helices connected by a non-helical "loop" segment. They are found in many sequence-specific DNA-BINDING PROTEINS and in CALCIUM-BINDING PROTEINS.Nuclear Proteins: Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.Mice, Knockout: Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.CCAAT-Enhancer-Binding Protein-alpha: A CCAAT-enhancer-binding protein found in LIVER; ADIPOSE TISSUE; INTESTINES; LUNG; ADRENAL GLANDS; PLACENTA; OVARY and peripheral blood mononuclear cells (LEUKOCYTES, MONONUCLEAR). Experiments with knock-out mice have demonstrated that CCAAT-enhancer binding protein-alpha is essential for the functioning and differentiation of HEPATOCYTES and ADIPOCYTES.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Upstream Stimulatory Factors: Ubiquitously expressed basic HELIX-LOOP-HELIX MOTIF transcription factors. They bind CANNTG sequences in the promoters of a variety of GENES involved in carbohydrate and lipid metabolism.CCAAT-Enhancer-Binding Proteins: A class of proteins that were originally identified by their ability to bind the DNA sequence CCAAT. The typical CCAAT-enhancer binding protein forms dimers and consists of an activation domain, a DNA-binding basic region, and a leucine-rich dimerization domain (LEUCINE ZIPPERS). CCAAT-BINDING FACTOR is structurally distinct type of CCAAT-enhancer binding protein consisting of a trimer of three different subunits.Repressor Proteins: Proteins which maintain the transcriptional quiescence of specific GENES or OPERONS. Classical repressor proteins are DNA-binding proteins that are normally bound to the OPERATOR REGION of an operon, or the ENHANCER SEQUENCES of a gene until a signal occurs that causes their release.Protein Structure, Tertiary: The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.Cell Differentiation: Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.Activating Transcription Factor 3: An activating transcription factor that plays a key role in cellular responses to GENOTOXIC STRESS and OXIDATIVE STRESS.DNA: A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).Activating Transcription Factors: Activating transcription factors were originally identified as DNA-BINDING PROTEINS that interact with early promoters from ADENOVIRUSES. They are a family of basic leucine zipper transcription factors that bind to the consensus site TGACGTCA of the cyclic AMP response element, and are closely related to CYCLIC AMP-RESPONSIVE DNA-BINDING PROTEIN.Transfection: The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.Gene Expression Regulation, Developmental: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.Proto-Oncogene Proteins c-jun: Cellular DNA-binding proteins encoded by the c-jun genes (GENES, JUN). They are involved in growth-related transcriptional control. There appear to be three distinct functions: dimerization (with c-fos), DNA-binding, and transcriptional activation. Oncogenic transformation can take place by constitutive expression of c-jun.Dimerization: The process by which two molecules of the same chemical composition form a condensation product or polymer.Activating Transcription Factor 4: An activating transcription factor that regulates the expression of a variety of GENES involved in amino acid metabolism and transport. It also interacts with HTLV-I transactivator protein.Transcription Factor AP-1: A multiprotein complex composed of the products of c-jun and c-fos proto-oncogenes. These proteins must dimerize in order to bind to the AP-1 recognition site, also known as the TPA-responsive element (TRE). AP-1 controls both basal and inducible transcription of several genes.Sp1 Transcription Factor: Promoter-specific RNA polymerase II transcription factor that binds to the GC box, one of the upstream promoter elements, in mammalian cells. The binding of Sp1 is necessary for the initiation of transcription in the promoters of a variety of cellular and viral GENES.Recombinant Fusion Proteins: Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.Cloning, Molecular: The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.Cyclic AMP Response Element-Binding Protein: A protein that has been shown to function as a calcium-regulated transcription factor as well as a substrate for depolarization-activated CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES. This protein functions to integrate both calcium and cAMP signals.Activating Transcription Factor 2: An activating transcription factor that regulates expression of a variety of GENES including C-JUN GENES; CYCLIN A; CYCLIN D1; and ACTIVATING TRANSCRIPTION FACTOR 3.Cell Nucleus: Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)Nuclear Respiratory Factor 1: A transcription factor that controls the expression of variety of proteins including CYTOCHROME C and 5-AMINOLEVULINATE SYNTHETASE. It plays an important role in maintenance of the RESPIRATORY CHAIN of MITOCHONDRIA.NF-E2 Transcription Factor: A basic-leucine zipper transcription factor that regulates GLOBIN gene expression and is related to TRANSCRIPTION FACTOR AP-1. NF-E2 consists of a small MAF protein subunit and a tissue-restricted 45 kDa subunit.Basic Helix-Loop-Helix Transcription Factors: A family of DNA-binding transcription factors that contain a basic HELIX-LOOP-HELIX MOTIF.Electrophoretic Mobility Shift Assay: An electrophoretic technique for assaying the binding of one compound to another. Typically one compound is labeled to follow its mobility during electrophoresis. If the labeled compound is bound by the other compound, then the mobility of the labeled compound through the electrophoretic medium will be retarded.HeLa Cells: The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.Sequence Alignment: The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.Genes, Reporter: Genes whose expression is easily detectable and therefore used to study promoter activity at many positions in a target genome. In recombinant DNA technology, these genes may be attached to a promoter region of interest.MafK Transcription Factor: A small Maf protein involved in differentiation of ERYTHROID CELLS. MafK was originally described as the small subunit of the NF-E2 Transcription Factor, but other small MAF PROTEINS also serve as NF-E2 subunits.NF-E2 Transcription Factor, p45 Subunit: A tissue-specific subunit of NF-E2 transcription factor that interacts with small MAF PROTEINS to regulate gene expression. P45 NF-E2 protein is expressed primarily in MEGAKARYOCYTES; ERYTHROID CELLS; and MAST CELLS.Homeodomain Proteins: Proteins encoded by homeobox genes (GENES, HOMEOBOX) that exhibit structural similarity to certain prokaryotic and eukaryotic DNA-binding proteins. Homeodomain proteins are involved in the control of gene expression during morphogenesis and development (GENE EXPRESSION REGULATION, DEVELOPMENTAL).Nuclear Respiratory Factors: A family of transcription factors that control expression of a variety of nuclear GENES encoding proteins that function in the RESPIRATORY CHAIN of the MITOCHONDRIA.Saccharomyces cerevisiae Proteins: Proteins obtained from the species SACCHAROMYCES CEREVISIAE. The function of specific proteins from this organism are the subject of intense scientific interest and have been used to derive basic understanding of the functioning similar proteins in higher eukaryotes.Fungal Proteins: Proteins found in any species of fungus.DNA, Complementary: Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.Forkhead Transcription Factors: A subclass of winged helix DNA-binding proteins that share homology with their founding member fork head protein, Drosophila.Saccharomyces cerevisiae: A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement.Luciferases: Enzymes that oxidize certain LUMINESCENT AGENTS to emit light (PHYSICAL LUMINESCENCE). The luciferases from different organisms have evolved differently so have different structures and substrates.Phosphorylation: The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.Recombinant Proteins: Proteins prepared by recombinant DNA technology.Transcription Factor AP-2: A family of DNA binding proteins that regulate expression of a variety of GENES during CELL DIFFERENTIATION and APOPTOSIS. Family members contain a highly conserved carboxy-terminal basic HELIX-TURN-HELIX MOTIF involved in dimerization and sequence-specific DNA binding.Blotting, Western: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.DNA Primers: Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.Zinc Fingers: Motifs in DNA- and RNA-binding proteins whose amino acids are folded into a single structural unit around a zinc atom. In the classic zinc finger, one zinc atom is bound to two cysteines and two histidines. In between the cysteines and histidines are 12 residues which form a DNA binding fingertip. By variations in the composition of the sequences in the fingertip and the number and spacing of tandem repeats of the motif, zinc fingers can form a large number of different sequence specific binding sites.Chromatin Immunoprecipitation: A technique for identifying specific DNA sequences that are bound, in vivo, to proteins of interest. It involves formaldehyde fixation of CHROMATIN to crosslink the DNA-BINDING PROTEINS to the DNA. After shearing the DNA into small fragments, specific DNA-protein complexes are isolated by immunoprecipitation with protein-specific ANTIBODIES. Then, the DNA isolated from the complex can be identified by PCR amplification and sequencing.Genes, Plant: The functional hereditary units of PLANTS.Plasmids: Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.Two-Hybrid System Techniques: Screening techniques first developed in yeast to identify genes encoding interacting proteins. Variations are used to evaluate interplay between proteins and other molecules. Two-hybrid techniques refer to analysis for protein-protein interactions, one-hybrid for DNA-protein interactions, three-hybrid interactions for RNA-protein interactions or ligand-based interactions. Reverse n-hybrid techniques refer to analysis for mutations or other small molecules that dissociate known interactions.Kruppel-Like Transcription Factors: A family of zinc finger transcription factors that share homology with Kruppel protein, Drosophila. They contain a highly conserved seven amino acid spacer sequence in between their ZINC FINGER MOTIFS.Transcription Factors, TFII: The so-called general transcription factors that bind to RNA POLYMERASE II and that are required to initiate transcription. They include TFIIA; TFIIB; TFIID; TFIIE; TFIIF; TFIIH; TFII-I; and TFIIJ. In vivo they apparently bind in an ordered multi-step process and/or may form a large preinitiation complex called RNA polymerase II holoenzyme.Reverse Transcriptase Polymerase Chain Reaction: A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.Oryza sativa: Annual cereal grass of the family POACEAE and its edible starchy grain, rice, which is the staple food of roughly one-half of the world's population.Gene Expression: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.Gene Expression Regulation, Viral: Any of the processes by which cytoplasmic factors influence the differential control of gene action in viruses.Enhancer Elements, Genetic: Cis-acting DNA sequences which can increase transcription of genes. Enhancers can usually function in either orientation and at various distances from a promoter.Regulatory Sequences, Nucleic Acid: Nucleic acid sequences involved in regulating the expression of genes.YY1 Transcription Factor: A ubiquitously expressed zinc finger-containing protein that acts both as a repressor and activator of transcription. It interacts with key regulatory proteins such as TATA-BINDING PROTEIN; TFIIB; and ADENOVIRUS E1A PROTEINS.STAT3 Transcription Factor: A signal transducer and activator of transcription that mediates cellular responses to INTERLEUKIN-6 family members. STAT3 is constitutively activated in a variety of TUMORS and is a major downstream transducer for the CYTOKINE RECEPTOR GP130.GATA4 Transcription Factor: A GATA transcription factor that is expressed in the MYOCARDIUM of developing heart and has been implicated in the differentiation of CARDIAC MYOCYTES. GATA4 is activated by PHOSPHORYLATION and regulates transcription of cardiac-specific genes.NF-kappa B: Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.Transcription Factor TFIID: The major sequence-specific DNA-binding component involved in the activation of transcription of RNA POLYMERASE II. It was originally described as a complex of TATA-BOX BINDING PROTEIN and TATA-BINDING PROTEIN ASSOCIATED FACTORS. It is now know that TATA BOX BINDING PROTEIN-LIKE PROTEINS may take the place of TATA-box binding protein in the complex.

Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3. (1/1416)

The NF-E2-binding sites or Maf recognition elements (MARE) are essential cis-acting elements in the regulatory regions of erythroid-specific genes recognized by the erythroid transcription factor NF-E2, composed of p45 and MafK. Recently, two p45-related factors Nrf1 and Nrf2 were isolated, and they are now collectively grouped as the Cap'n' collar (CNC) family. CNC factors bind to MARE through heterodimer formation with small Maf proteins. We report here the identification and characterization of a novel CNC factor, Nrf3, encoding a predicted 73-kDa protein with a basic region-leucine zipper domain highly homologous to those of other CNC proteins. In vitro and in vivo analyses showed that Nrf3 can heterodimerize with MafK and that this complex binds to the MARE in the chicken beta-globin enhancer and can activate transcription. Nrf3 mRNA is highly expressed in human placenta and B cell and monocyte lineage. Chromosomal localization of human Nrf3 is 7p14-15, which lies near the hoxA gene locus. As the genetic loci of p45, nrf1, and nrf2 have been mapped close to those of hoxC, hoxB, and hoxD, respectively, the present study strongly argues for the idea that a single ancestral gene for the CNC family members may have been localized near the ancestral Hox cluster and have diverged to give rise to four closely related CNC factors through chromosome duplication.  (+info)

Silencing of the Epstein-Barr virus latent membrane protein 1 gene by the Max-Mad1-mSin3A modulator of chromatin structure. (2/1416)

The tumor-associated latent membrane protein 1 (LMP1) gene in the Epstein-Barr virus (EBV) genome is activated by EBV-encoded proteins and cellular factors that are part of general signal transduction pathways. As previously demonstrated, the proximal region of the LMP1 promoter regulatory sequence (LRS) contains a negative cis element with a major role in EBNA2-mediated regulation of LMP1 gene expression in B cells. Here, we show that this silencing activity overlaps with a transcriptional enhancer in an LRS sequence that contains an E-box-homologous motif. Mutation of the putative repressor binding site relieved the repression both in a promoter-proximal context and in a complete LRS context, indicating a functional role of the repressor. Gel retardation assays showed that members of the basic helix-loop-helix transcription factor family, including Max, Mad1, USF, E12, and E47, and the corepressor mSin3A bound to the E-box-containing sequence. The enhancer activity correlated with the binding of USF. Moreover, the activity of the LMP1 promoter in reporter constructs was upregulated by overexpression of USF1 and USF2a, and the transactivation was inhibited by the concurrent expression of Max and Mad1. This suggests that Max-Mad1-mediated anchorage of a multiprotein complex including mSin3A and histone deacetylases to the E-box site constitutes the basis for the repression. Removal of acetyl moieties from histones H3 and H4 should result in a chromatin structure that is inaccessible to transcription factors. Accordingly, inhibition of deacetylase activity with trichostatin A induced expression of the endogenous LMP1 gene in EBV-transformed cells.  (+info)

Transcriptional repression of human hepatitis B virus genes by a bZIP family member, E4BP4. (3/1416)

Box alpha is an essential element of both the upstream regulatory sequence of the core promoter and the second enhancer, which positively regulate the transcription of human hepatitis B virus (HBV) genes. In this paper, we describe the cloning and characterization of a box alpha binding protein, E4BP4. E4BP4 is a bZIP type of transcription factor. Overexpression of E4BP4 represses the stimulating activity of box alpha in the upstream regulatory sequence of the core promoter and the second enhancer in differentiated human hepatoma cell lines. E4BP4 can also suppress the transcription of HBV genes and the production of HBV virions in a transient-transfection system that mimics the viral infection in vivo. Expression of an E4BP4 antisense transcript can, instead, elevate the transcription of the core promoter. A low abundance of E4BP4 protein and mRNA in differentiated human hepatoma cell lines is detected, and E4BP4 is not a major component of box alpha binding proteins in untransfected differentiated human hepatoma cell lines. C/EBPalpha and C/EBPbeta, in contrast, are major components of the box alpha binding activity present in nuclear extracts. E4BP4 has a stronger binding affinity towards box alpha than the endogenous box alpha binding activity present in nuclear extracts. Structure and function analysis of E4BP4 reveals that DNA binding activity is sufficient to confer the negative regulatory function of E4BP4. These results indicate that binding site occlusion is the mechanism whereby E4BP4 suppresses transcription in HBV.  (+info)

Two distinct interleukin-3-mediated signal pathways, Ras-NFIL3 (E4BP4) and Bcl-xL, regulate the survival of murine pro-B lymphocytes. (4/1416)

Hematopoietic cells require cytokine-initiated signals for survival as well as proliferation. The pathways that transduce these signals, ensuring timely regulation of cell fate genes, remain largely undefined. The NFIL3 (E4BP4) transcription factor, Bcl-xL, and constitutively active mutants of components in Ras signal transduction pathways have been identified as key regulation proteins affecting murine interleukin-3 (IL-3)-dependent cell survival. Here we show that expression of NFIL3 is regulated by oncogenic Ras mutants through both the Raf-mitogen-activated protein kinase and phosphatidylinositol 3-kinase pathways. NFIL3 inhibits apoptosis without affecting Bcl-xL expression. By contrast, Bcl-xL levels are regulated through the membrane proximal portion in the cytoplasmic domain of the receptor (betac chain), which is shared by IL-3 and granulocyte-macrophage colony-stimulating factor. Activation of either pathway alone is insufficient to ensure cell survival, indicating that multiple independent signal transduction pathways mediate the survival of developing B-lymphoid cells.  (+info)

Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) encodes a homologue of the Epstein-Barr virus bZip protein EB1. (5/1416)

Analysis of the recently completed genomic sequence of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) revealed that ORF 50 encodes a protein with homology to the Epstein-Barr virus (EBV) transcription factor R. In this report, we show that ORF K8, contiguous to ORF 50, is interrupted by two introns and that the spliced RNA is translated into a bZip protein that has homology to the EBV transcription factor EB1. The newly characterized K8 protein forms homodimers but does not heterodimerize with other members of the bZip protein family.  (+info)

Multiple regulatory elements control the expression of the yeast ACR1 gene. (6/1416)

The ACR1 gene, encoding a succinate-fumarate transporter, is required by the yeast Saccharomyces cerevisiae for ethanol utilization. Accordingly, gene expression is induced by ethanol and repressed by glucose. Here, we investigated three carbon source response elements present in its promoter region. Specific deletions as well as functional analysis of the elements in a heterologous promoter confirmed their role in transcriptional regulation. Protein binding to carbon source response elements of the ICL1 promoter was competed by all three elements to various extents by the respective ACR1 sequences. In addition, two putative stress response promoter elements present in the ACR1 promoter were investigated in deletion analyses and shown to contribute to gene expression.  (+info)

A novel human DNA-binding protein with sequence similarity to a subfamily of redox proteins which is able to repress RNA-polymerase-III-driven transcription of the Alu-family retroposons in vitro. (7/1416)

In this study we identified a novel protein which may contribute to the transcriptional inactivity of Alu retroposons in vivo. A human cDNA clone encoding this protein (ACR1) was isolated from a human expression library using South-western screening with an Alu subfragment, implicated in the regulation of Alu in vitro transcription and interacting with a HeLa nuclear protein down-regulated in adenovirus-infected cells. Bacterially expressed ACR1 is demonstrated to inhibit RNA polymerase III (Pol III)-dependent Alu transcription in vitro but showed no repression of transcription of a tRNA gene or of a reporter gene under control of a Pol II promoter. ACR1 mRNA is also found to be down-regulated in adenovirus-infected HeLa cells, consistent with a possible repressor function of the protein in vivo. ACR1 is mainly (but not exclusively) located in cytoplasm and appears to be a member of a weakly characterized redox protein family having a central, highly conserved sequence motif, PGAFTPXCXXXXLP. One member of the family identified earlier as peroxisomal membrane protein (PMP)20 is known to interact in a sequence-specific manner with a yeast homolog of mammalian cyclosporin-A-binding protein cyclophilin, and mammalian cyclophilin A (an abundant ubiquitously expressed protein) is known to interact with human transcriptional repressor YY1, which is a major sequence-specific Alu-binding protein in human cells. It appears, therefore, that transcriptional silencing of Alu in vivo is a result of complex interactions of many proteins which bind to its Pol III promoter.  (+info)

Ubiquitination and degradation of ATF2 are dimerization dependent. (8/1416)

Ubiquitination and proteasome-dependent degradation are key determinants of the half-lives of many transcription factors. Homo- or heterodimerization of basic region-leucine zipper (bZIP) transcription factors is required for their transcriptional activities. Here we show that activating transcription factor 2 (ATF2) heterodimerization with specific bZIP proteins is an important determinant of the ubiquitination and proteasome-dependent degradation of ATF2. Depletion of c-Jun as one of the ATF2 heterodimer partners from the targeting proteins decreased the efficiency of ATF2 ubiquitination in vitro, whereas the addition of exogenously purified c-Jun restored it. Similarly, overexpression of c-Jun in 293T human embryo kidney cells increased ATF2 ubiquitination in vivo and reduced its half-life in a dose-dependent manner. Mutations of ATF2 that disrupt its dimerization inhibited ATF2 ubiquitination in vitro and in vivo. Conversely, removal of residues 150 to 248, as in a constitutively active ATF2 spliced form, enhanced ATF2 dimerization and transactivation, which coincided with increased ubiquitination and decreased stability. Our findings indicate the increased sensitivity of transcriptionally active dimers of ATF2 to ubiquitination and proteasome-dependent degradation. Based on these observations, we conclude that increased targeting of a transcriptionally active ATF2 form indicates the mechanism by which the magnitude and the duration of the cellular stress response are regulated.  (+info)

*Basic helix-loop-helix leucine zipper transcription factors

... are, as their name indicates, transcription factors containing both ... Basic helix-loop-helix leucine zipper transcription factors at the US National Library of Medicine Medical Subject Headings ( ... Basic helix-loop-helix and leucine zipper motifs. Examples include Microphthalmia-associated transcription factor and Sterol ...

*CHMP1A

Involvement of basic leucine zipper transcription factors". The Journal of Biological Chemistry. 273 (50): 33741-9. doi:10.1074 ... "Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins". ... MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor ...

*BATF (gene)

Basic leucine zipper transcription factor, ATF-like, also known as BATF, is a protein which in humans is encoded by the BATF ... "Entrez Gene: BATF basic leucine zipper transcription factor, ATF-like". Schraml BU, Hildner K, Ise W, Lee WL, Smith WA, Solomon ... protein that belongs to the AP-1/ATF superfamily of transcription factors. The leucine zipper of this protein mediates ... The protein encoded by this gene is a nuclear basic leucine zipper (bZIP) ...

*BATF2

Basic leucine zipper transcription factor, ATF-like 2 is a protein that, in humans, is encoded by the BATF2 gene. "Entrez Gene ... Basic leucine zipper transcription factor, ATF-like 2". Retrieved 2014-07-06. Ma, H; Liang, X; Chen, Y; Pan, K; Sun, J; Wang, H ... Huang, Q; Yang, Y; Li, X; Huang, S (2011). "Transcription suppression of SARI (suppressor of AP-1, regulated by IFN) by BCR-ABL ...

*ATF6

Involvement of basic leucine zipper transcription factors". J. Biol. Chem. 273 (50): 33741-9. doi:10.1074/jbc.273.50.33741. ... Hai TW, Liu F, Coukos WJ, Green MR (1990). "Transcription factor ATF cDNA clones: an extensive family of leucine zipper ... "Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding ... Activating transcription factor ATF6 has been shown to interact with YY1 and Serum response factor. GRCh38: Ensembl release 89 ...

*BACH1

This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family ( ... "Entrez Gene: BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1". Ozono R (Apr 2006). "New ... belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription ... of the mouse Bach1 gene encoding a BTB-basic leucine zipper transcription factor and its mapping to chromosome 21q22.1". ...

*BACH2

"Entrez Gene: BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2". Rosbrook GO, Stead MA, Carr SB, Wright ... belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription ... "A combinatorial code for gene expression generated by transcription factor Bach2 and MAZR (MAZ-related factor) through the BTB/ ... Vieira SA, Deininger MW, Sorour A, Sinclair P, Foroni L, Goldman JM, Melo JV (Dec 2001). "Transcription factor BACH2 is ...

*Sudip Chattopadhyay

"A Basic Leucine Zipper Transcription Factor, G-box-binding Factor 1, Regulates Blue Light-mediated Photomorphogenic Growth in ... They have also been successful in demonstrating the correlation between Z-box binding factors and other transcription factors ... The team led by him was successful in synthesizing Z-box binding transcription factors such as ZBF1, ZBF2 and ZBF3 and ... Mallappa, Chandrashekara; Singh, Aparna; Ram, Hathi; Chattopadhyay, Sudip (2008-12-19). "GBF1, a Transcription Factor of Blue ...

*Leucine zipper

Leucine zippers are a dimerization domain of the bZIP (Basic-region leucine zipper) class of eukaryotic transcription factors. ... "Genomic survey and gene expression analysis of the basic leucine zipper transcription factor family in rice". Plant Physiology ... Leucine zipper regulatory proteins include c-fos and c-jun (the AP1 transcription factor), important regulators of normal ... Nantel, A; Quatrano, R. S. (1996). "Characterization of three rice basic/leucine zipper factors, including two inhibitors of ...

*MAFK

... is one of the small Maf proteins, which are basic region and basic leucine zipper (bZIP)-type transcription factors. The ... "The basic region and leucine zipper transcription factor MafK is a new nerve growth factor-responsive immediate early gene that ... belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription ... belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription ...

*MAFG

... is one of the small Maf proteins, which are basic region and basic leucine zipper (bZIP)-type transcription factors. The ... belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription ... Transcription factor MafG is a bZip Maf transcription factor protein that in humans is encoded by the MAFG gene. ... MafG has a bZIP structure that consists of a basic region for DNA binding and a leucine zipper structure for dimer formation. ...

*Small Maf

Oyake, T (1996). "Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with ... Small Maf (musculoaponeurotic fibrosarcoma) proteins are basic region leucine zipper-type transcription factors that can bind ... sMafs form homodimers by themselves and heterodimers with other specific bZIP transcription factors, such as transcription ... the Maf family including sMafs have a bZIP structure that consists of the basic region for DNA binding and the leucine zipper ...

*NFE2L3

... is a transcription factor that in humans is encoded by the Nfe2l3 gene. This protein is a basic leucine zipper transcription ... Landschulz WH, Johnson PF, McKnight SL (June 1988). "The leucine zipper: a hypothetical structure common to a new class of DNA ... In 1989, the first CNC transcription factor was identified, namely NFE2L2. After that, several other protein members have also ... Terui K, Takahashi Y, Kitazawa J, Toki T, Yokoyama M, Ito E (December 2000). "Expression of transcription factors during ...

*MAFB (gene)

MafB is a basic leucine zipper (bZIP) transcription factor that plays an important role in the regulation of lineage-specific ... "The mouse segmentation gene kr encodes a novel basic domain-leucine zipper transcription factor". Cell. 79 (6): 1025-34. doi: ... "The mouse segmentation gene kr encodes a novel basic domain-leucine zipper transcription factor". Cell. 79 (6): 1025-34. doi: ... Transcription factor MafB also known as V-maf musculoaponeurotic fibrosarcoma oncogene homolog B is a protein that in humans is ...

*NRL (gene)

This gene encodes a basic motif-leucine zipper transcription factor of the Maf subfamily. The encoded protein is conserved ... "The minimal transactivation domain of the basic motif-leucine zipper transcription factor NRL interacts with TATA-binding ... "A conserved retina-specific gene encodes a basic motif/leucine zipper domain". Proceedings of the National Academy of Sciences ... Neural retina-specific leucine zipper protein is a protein that in humans is encoded by the NRL gene. ...

*DBP (gene)

DBP is a member of the PAR bZIP (Proline and Acidic amino acid-Rich basic leucine ZIPper) transcription factor family. DBP ... and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGF)". Genomics. 13 (2 ... and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGF)". Genomics. 13 (2 ... "Synergy between transcription factors DBP and C/EBP compensates for a haemophilia B Leyden factor IX mutation". Nature Genetics ...

*Ccaat-enhancer-binding proteins

"Structural basis for DNA recognition by the basic region leucine zipper transcription factor CCAAT/enhancer-binding protein ... This domain is involved in dimerization and DNA binding, as are other transcription factors of the leucine zipper domain- ... They are characterized by a highly conserved basic-leucine zipper (bZIP) domain at the C-terminus. ... CCAAT-enhancer-binding proteins (or C/EBPs) is a family of transcription factors composed of six members, named from C/EBPα to ...

*NFE2L1

... basic-leucine zipper (bZIP) transcription factor. Several isoforms of NFE2L1 have been described for both human and mouse genes ... Kwong M, Kan YW, Chan JY (Dec 1999). "The CNC basic leucine zipper factor, Nrf1, is essential for cell survival in response to ... "The Fbw7 tumor suppressor regulates nuclear factor E2-related factor 1 transcription factor turnover through proteasome- ... Oh DH, Rigas D, Cho A, Chan JY (Nov 2012). "Deficiency in the nuclear-related factor erythroid 2 transcription factor (Nrf1) ...

*NFE2L2

Nrf2 is a basic leucine zipper (bZip) transcription factor with a Cap "n" Collar (CNC) structure. Nrf2 possesses six highly ... NFE2L2 and other genes, such as NFE2, NFE2L1 and NFE2L3, encode basic leucine zipper (bZIP) transcription factors. They share ... is a transcription factor that in humans is encoded by the NFE2L2 gene. Nrf2 is a basic leucine zipper (bZIP) protein that ... "Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the ...

*MLX (gene)

The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These ... a gene at 17q21.1 encoding a putative basic helix-loop-helix leucine-zipper transcription factor". Gene. 181 (1-2): 7-11. doi: ... Billin AN, Eilers AL, Coulter KL, Logan JS, Ayer DE (December 2000). "MondoA, a novel basic helix-loop-helix-leucine zipper ... is a new member of the Mlx transcription factor network". Human Molecular Genetics. 10 (6): 617-27. doi:10.1093/hmg/10.6.617. ...

*Carbohydrate-responsive element-binding protein

This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc / Max / Mad superfamily. This protein ... de Luis O, Valero MC, Jurado LA (2000). "WBSCR14, a putative transcription factor gene deleted in Williams-Beuren syndrome: ... is a new member of the Mlx transcription factor network". Hum. Mol. Genet. 10 (6): 617-27. doi:10.1093/hmg/10.6.617. PMID ... is a new member of the Mlx transcription factor network". Hum. Mol. Genet. 10 (6): 617-27. doi:10.1093/hmg/10.6.617. PMID ...

*Border cells (Drosophila)

... a basic region-leucine zipper transcription factor, and it was thus expected that one or more of its targets would be essential ... The transcription factor slbo which commandeers the transcription of several genes is believed to be central to this phenomenon ... It is now known that the transcription factor Slbo (slow border cells) is a master regulator of the migratory phenotype. The ...

*Sterol regulatory element-binding protein

SREBPs belong to the basic-helix-loop-helix leucine zipper class of transcription factors. Unactivated SREBPs are attached to ... a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene". Cell ... Gasic GP (Apr 1994). "Basic-helix-loop-helix transcription factor and sterol sensor in a single membrane-bound molecule". Cell ... Wang X, Sato R, Brown MS, Hua X, Goldstein JL (Apr 1994). "SREBP-1, a membrane-bound transcription factor released by sterol- ...

*Amino acid response

Membrane transporters Transcription factors from the basic region/leucine zipper (bZIP) superfamily Growth factors Metabolic ... a timed program of expression and promoter binding of nutrient-responsive basic region/leucine zipper transcription factors as ... 2007). "The p300/CBP-associated factor (PCAF) is a cofactor of ATF4 for amino acid-regulated transcription of CHOP". Nucleic ... and results in an increase in activating transcription factor ATF4, which in turn affect many process by sundry pathways to ...

*BZLF1

It has a basic leucine zipper domain, a characteristic of many transcription factors. ZEBRA binds to the oriLyt (lytic origin ... Schepers, A.; Pich, D.; Hammerschmidt, W.(1993). Transcription factor with homology to the AP-1 family links RNA transcription ... 2009). Epstein-Barr virus polymerase processivity factor enhances BALF2 promoter transcription as a coactivator for the BZLF1 ... It interacts with the viral helicase-primase complex and BMRF1, the viral polymerase accessory factor. It has been shown to ...

*AP-1 transcription factor

... is assembled through the dimerization of a characteristic bZIP domain (basic region leucine zipper) ... A typical bZIP domain consists of a "leucine zipper" region, and a "basic region". The leucine zipper is responsible for ... Apart from the "leucine zipper" and the "basic region" which are important for dimerization and DNA-binding, the c-jun protein ... The basic region of the bZIP domain is just upstream to the leucine zipper, and contains positively charged residues. This ...
nitrogen-rich conditions. URS1-CYC1-Ub-X-lacZ reporters were expressed in mitotic repression machinery mutants (ume6Δ, rpd3Δ, sin3Δ, isw2Δ and itc1Δ) under nitrogen rich conditions. The data presented here from these experiments not only corroborates their known role in repression at URS1 but also suggested regulation at additional sites in the minimal CYC1 promoter. Deletion of Sin3p suggested independent repression function separable from Rpd3p. Isw2p also acts independently of Itc1p at sites other than URS1. We also show that pseudohyphal growth was stimulated by non-fermentable carbon sources in sporulation efficient SK1 genetic background. The data also indicates that stimulation of pseudohyphal growth by non-fermentable carbon sources does not require respiration function or functional mitochondrial RTG pathway. ...
Lateral organs formed by the shoot apical meristem (SAM) are separated from surrounding stem cells by regions of low growth called boundaries. Arabidopsis (Arabidopsis thaliana) BLADE-ON-PETIOLE1 (BOP1) and BOP2 represent a class of genes important for boundary patterning in land plants. Members of this family lack a DNA-binding domain and interact with TGACG-motif binding (TGA) basic Leu zipper (bZIP) transcription factors for recruitment to DNA. Here, we show that clade I bZIP transcription factors TGA1 and TGA4, previously associated with plant defense, are essential cofactors in BOP-dependent regulation of development. TGA1 and TGA4 are expressed at organ boundaries and function in the same genetic pathways as BOP1 and BOP2 required for SAM maintenance, flowering, and inflorescence architecture. Further, we show that clade I TGAs interact constitutively with BOP1 and BOP2, contributing to activation of ARABIDOPSIS THALIANA HOMEOBOX GENE1, which is needed for boundary establishment. These ...
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Batf2 belongs to the AP-1 basic leucine zipper transcription factor (activating transcription factor) family proteins, composed of Batf, Batf2, and Batf3 (26-29, 35), with Batf2 having very limited functional information available. Batf family proteins do not have a DNA binding domain and bind to DNA indirectly with support of other transcription factors. In this study, we demonstrate that Batf2 is involved in gene regulation of IFN-γ-activated classical macrophages as well as LPS/TLR-induced macrophage stimulation. Batf2, most probably in complex with the transcription factor Irf1, induces important classical effector genes in macrophages, among them Tnf, Nos2, Ccl5, and Il12b for inflammatory responses against type 1 infectious diseases, such as M. tuberculosis.. Gene expression studies in IFN-γ-activated M1 and in TLR-stimulated macrophages revealed a strong induction of the transcription factor Batf2, which was not observed in unstimulated or IL-4-activated M2, and hence Batf2 can be ...
November 22, 2017. A research group at Lund University in Sweden has found that when the HLF (hepatic leukemia factor) gene -which is expressed in immature blood cells - does not shut down on time, we are unable to develop a functional long-term immune system. This could be a very early stage of leukemia.. Blood stem cells give rise to all of our blood cells: the red blood cells that transport oxygen, the platelets that enable blood coagulation, and our immune cells that protect us from infections. Immune cells can, in turn, be divided into two groups; one that consists of cells with a very short life expectancy and a natural but rather unspecific ability to counteract infections (myeloid cells), and another that, in contrast, consists of very long-lived cells (lymphocytes) that specialise in combatting specific bacteria and viruses.. "The ability of blood stem cells to form all types of blood cells is a fundamental property that is also utilized in connection with bone marrow transplants. An ...
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Mouse polyclonal antibody raised against a partial recombinant SNFT. SNFT (NP_061134, 48 a.a. ~ 125 a.a) partial recombinant protein with GST tag. (H00055509-A01) - Products - Abnova
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NFIL3山羊多克隆抗体(ab1078)可与人样本反应并经WB实验严格验证,被1篇文献引用。中国75%以上现货,所有产品均提供质保服务,可通过电话、电邮或微信获得本地专属技术支持。
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hypothetical protein, A306_16176, Anapl_09380, AS27_04981, AS28_10071, BTB and CNC homolog 2, BTB and CNC homology 1, basic leucine zipper transcription facto, BTB and CNC homology 1, basic leucine zipper transcription factor 2, BTB and CNC homology 2, BTB and CNC homology, basic leucine zipper transcription factor 2, BTB and CNC-like protein 2, BTB and CNC-like proteiny 1, basic leucine zipper transcription factor 2, BTBD25, CB1_000371003, D623_10023882, EGK_15169, GW7_21221, H920_09183, M91_21520, N300_01162, N301_04236, N302_15591, N303_00283, N306_11786, N307_06313, N309_15054, N312_12567, N320_02542, N321_10716, N322_10547, N324_08521, N325_01813, N326_10621, N327_13435, N329_07672, N330_12030, N332_00603, N333_12747, N334_07268, N335_02849, N336_03526, N339_08762, N340_07775, N341_06653, PAL_GLEAN10025165, PANDA_014576, RGD1562865, Transcription regulator protein BACH2, Transcription regulator protein BACH2 (BTB and CNC homolog 2), transcription regulator protein BACH2-like protein, ...
Read "Bipartite determinants of DNA-binding specificity of plant basic leucine zipper proteins, Plant Molecular Biology" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
The basic leucine zipper transcription factor ATF5 is overexpressed in many tumor types and interference with its expression or function inhibits cancer cell survival. As a potential therapeutic approach to exploit these findings, we created dominant-negative (DN) ATF5 forms lacking DNA-binding ability that retain the ATF5 leucine zipper, and thus associate with and sequester ATF5s requisite leucine zipper-binding partners. Preclinical studies with DN-ATF5, including a cell-penetrating form, show in vitro and in vivo efficacy in compromising cancer cell survival. However, DN-ATF5s targets, and particularly those required for tumor cell survival, have been unknown. We report that cells lacking ATF5 succumb to DN-ATF5, indicating that ATF5 itself is not DN-ATF5s obligate target. Unbiased pull-down assays coupled with mass spectrometry and immunoblotting revealed that DN-ATF5 associates in cells with the basic leucine zipper proteins CEBPB and CEBPD and coiled-coil protein CCDC6. Consistent with ...
The Oxidative Stress Responsive Transcription Factor Pap1 Confers DNA Damage Resistance on Checkpoint-Deficient Fission Yeast Cells. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
According to the prediction of the involvement of bZIP transcription factors in the ER stress response, AtbZIP60 was identified by genome-wide screening based on genomic information on Arabidopsis. Tunicamycin and other reagents activating the ER stress response induced transcripts of AtbZIP60. From these results, we predicted that AtbZIP60 plays a role in the ER stress response. Because the expression profile of AtbZIP60 was close to that of BiP, induction of AtbZIP60 transcript was not considered to be the first trigger of activation for BiP expression. Instead, it was assumed that a conformational change of AtbZIP60 activates the expression of chaperone genes, such as BiP. This prediction was based on the fact that AtbZIP60 contains a putative TMD like that of ATF6 in mammalian cells. Specifically, it was hypothesized that AtbZIP60 is converted to a soluble form by ER stress and becomes localized to the nucleus, resulting in the activation of chaperone genes. Indeed, a truncated form of ...
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
Monoclonal antibody against BTB and CNC homology 1, basic leucine zipper transcription factor 2 expressed by BACH2 for use in Immunoprecipitation, Microarray against Human
The physiological roles of the mitochondrial transcription termination factor (mTERF) family are poorly understood. MTERF and its homologues influence transcriptional readthrough in vitro, but the extent to which they regulate mitochondrial RNA levels in vivo is unclear. In addition, MTERF was previously shown to promote replication pausing. To test their roles in mtDNA metabolism, we created cell-lines inducibly expressing epitope-tagged versions of two members of the mTERF family, MTERFD1 and MTERFD3, as well as shRNA constructs targeted at each. We confirmed mitochondrial targeting and lack of sequence-specific DNA binding for both factors. Over-expression of epitope-tagged MTERFD1 or MTERFD3 resulted in modest mtDNA copy-number depletion and an accumulation of specific mtDNA replication intermediates indicating an impairment of the terminal steps of replication. These findings further implicate the mTERF family in restraining replication fork progression and support the idea that they ...
G-protein coupled receptor kinase 1 (Grk1) is essential for light-activated opsin phosphorylation in phototransduction shutoff, and genetic defects cause Oguchis disease, a form of Retinitis Pigmentosa (RP). To elucidate the recovery function of cone pigments, we combined Grk1-/- murine knockouts with the Neural retina leucine zipper (Nrl-/-), which have an enhanced S-cone phenotype. We observed that with increasing age and independent of light, the retinas of Nrl-/-Grk1-/- when compared to Nrl-/- developed progressive cone degeneration and decreased cone protein expression. The degeneration initially occurs in the central inferior quadrant and spreads with retinal pigment epithelia (RPE) atrophy. Endothelial cell specific immunohistochemistry and fluorescein angiography (FA) revealed progressive changes in retinal neovascularization in the Nrl-/-Grk1-/- at 1 month of age, prior to the onset of significant cone functional deficits and ONL thinning. Vascular Endothelial Growth Factor (VEGF) ...
BACH1 antibody [N2C1], Internal (BTB and CNC homology 1, basic leucine zipper transcription factor 1) for WB. Anti-BACH1 pAb (GTX110292) is tested in Human samples. 100% Ab-Assurance.
The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA and recruiting Sin3 corepressor proteins through its N-terminal Sin3-interaction domain [1][4] ...
endothelial PAS domain-containing protein 1: a Per-Arnt/AhR-Sim basic helix-loop-helix factor similar to hypoxia-inducible factor 1alpha; RefSeq NM_010137 (mouse); do not confuse with hepatic leukemia factor
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The KOMP Repository is located at the University of California Davis and Childrens Hospital Oakland Research Institute. Question? Comments? For Mice, Cells, and germplasm please contact us at [email protected], US 1-888-KOMP-MICE or International +1-530-752-KOMP, or for vectors [email protected] or +1-510-450-7917 ...
Myc and Max proteins complexed with target DNA (deoxyribonucleic acid). Computer model showing human Myc proto-oncogene protein (purple) and Max protein (green) complexed with synthetic DNA (red, beige). - Stock Image C035/8134
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BZW2 overexpression lysate, 0.1 mg. Transient overexpression lysate of basic leucine zipper and W2 domains 2 (BZW2), transcript variant 2
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Hello vex and ame - recruitment is still closed for now till summer wraps up and 4.1 drops. I believe we will re-open shortly after 4.1. Thanks ...
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BZIP domain: The Basic Leucine Zipper Domain ( bZIP domain ) is found in many DNA binding eukaryotic proteins. One part of the domain contains a region that mediates sequence specific DNA binding properties and the leucine zipper that is required to hold together (dimerize) two DNA binding regions. The DNA binding region comprises a number of basic amino acids such as arginine and lysine. Proteins containing this domain are transcription factors. [Source: Wikipedia] ...
Activating Transcription Factors were originally identified as DNA-Binding Proteins that interact with early promoters from Adenoviruses. They are a Family of Basic Leucine Zipper Transcription Factors that bind to the Consensus site TGACGTCA of the Cyclic AMP Response Element, and are closely related to Cyclic AMP-Responsive DNA-Binding Protein ...
Plants have evolved a variety of mechanisms to adapt growth and development to the ambient light environment. To monitor the light, plants use several classes of photoreceptors (e.g. phytochromes, cryptochromes). Downstream of these photoreceptors, an important negative regulator, the COP1/SPA complex, suppresses light signaling in dark-grown Arabidopsis seedlings. This complex is an E3 ubiquitin ligase, i.e. an enzyme that attaches ubiquitin to other proteins which are subsequently recognized by the proteasome and degraded. The COP1/SPA ubiquitin ligase inhibits light signaling in darkness by ubiquitinating activators of the light response, such as the transcription factors HY5, LAF1 and HFR1. cop1 and spa mutants fail to degrade these transcription factors in darkness and, therefore, undergo constitutive photomorphogenesis showing features of light-grown plants even in complete darkness. In the light, active photoreceptors are thought to inhibit COP1/SPA function, thus HY5, LAF1 and HFR1 ...
0060]The present invention, thus, also encompasses an oligonucleotide which specifically binds to the polynucleotides of the present invention. Binding as meant in this context refers to hybridization by Watson-Crick base pairing discussed elsewhere in the specification in detail. An oligonucleotide as used herein has a length of at most 100, at most 50, at most 40, at most 30 or at most 20 nucleides in length which are complementary to the nucleic acid sequence of the polynucleotides of the present invention. The sequence of the oligonucleotide is, preferably, selected so that a perfect match by Watson-Crick base pairing will be obtained. The oligonucleotides of the present invention may be suitable as primers for PCR-based amplification techniques. Moreover, the oligonucleotides may be used for RNA interference (RNAi) approaches in order to modulate and, preferably down-regulate, the activity of the polypeptides encoded by the polynucleotides of the present invention. Thereby, an organism may ...
Transcription regulator protein BACH2 is a protein that in humans is encoded by the BACH2 gene. It contains a BTB/POZ domain at its N-terminus which forms a disulphide-linked dimer and a bZip_Maf domain at the C-terminus. Model organisms have been used in the study of BACH2 function. A conditional knockout mouse line called Bach2tm1a(EUCOMM)Wtsi was generated at the Wellcome Trust Sanger Institute. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping - in-depth bone and cartilage phenotyping GRCh38: Ensembl release 89: ENSG00000112182 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000040270 - Ensembl, May 2017 "Human PubMed Reference:". "Mouse PubMed Reference:". Sasaki S, Ito E, Toki T, Maekawa T, Kanezaki R, Umenai T, Muto A, Nagai H, Kinoshita T, Yamamoto M, Inazawa J, Taketo MM, Nakahata T, Igarashi K, Yokoyama M (Aug 2000). "Cloning and expression of human B ...
Gene target information for BZW2 - basic leucine zipper and W2 domains 2 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.
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Drops of Bach elderly help to get rid of unpleasant and painful relationships and situations that prevent professional or personal life.
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The Bach Players: Nicolette Moonen, Gawain Glenton, Emily White Krzysztof Lewandowski, Lynda Sayce and Silas Wollston. (Hyphen Press) This ninth CD by a deceptively titled The Bach Players is the ensembles debut release of early-Baroque repertoire. Played on period instruments - violin,.... Read more. ...
Raise your arms slightly and measure around your body. Be sure to measure the fullest part of your chest/bust, keeping the tape parallel to the ground. Waist: ...
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As a prominent oncomir, miR-155 plays a role in many of the above oncogenic processes. It down-regulates BCL6 (B-cell lymphoma 6) protein [8], which is an evolutionarily conserved zinc finger transcription factor that contains an N-terminal POZ/BTB domain. As BCL6 has been shown to modulate the STAT-dependent Interleukin 4 (IL-4) responses of B cells, miR-155 acts to increase B cell functioning. Also, since BCL6 interacts with several co-repressor complexes to inhibit transcription, and its gene is frequently trans-located and hyper-mutated in diffuse large B cell lymphoma (DLBCL), miR-155 acts to enhance transcription and contribute to the pathogenesis of DLBCL. Reduction of BCL6 then leads to up-regulation of known BCL6 targets such as inhibitor of differentiation (Id2), Interleukin-6 (IL6), cMyc, Cyclin D1, and Mip1α/Ccl3, all of which promote cell survival and proliferation [8].. MiR-155 also upregulates Mxd1/Mad1, a network of basic helix-loop-helix leucine zipper transcription factors ...
Transcription factor EB (TFEB) is a member of the MiTF/TFE (Microphthalmia/TFE) subfamily of basic/helix-loop-helix/leucine zipper transcription factors. This group of proteins is involved in the proliferation and development of specific cell types such as osteoclasts or melanocytes.
Nuclear factor (erythroid-derived 2)-like 2, also known as NFE2L2 or Nrf2, is a transcription factor that in humans is encoded by the NFE2L2 gene. Nrf2 is a basic leucine zipper (bZIP) protein that regulates the expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation. Several drugs that stimulate the NFE2L2 pathway are being studied for treatment of diseases that are caused by oxidative stress. NFE2L2 and other genes, such as NFE2, NFE2L1 and NFE2L3, encode basic leucine zipper (bZIP) transcription factors. They share highly conserved regions that are distinct from other bZIP families, such as JUN and FOS, although remaining regions have diverged considerably from each other. Under normal or unstressed conditions, Nrf2 is kept in the cytoplasm by a cluster of proteins that degrade it quickly. Under oxidative stress, Nrf2 is not degraded, but instead travels to the nucleus where it binds to a DNA promoter and initiates transcription of ...
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Primary patterning of the Dictyostelium slug creates an anterior prestalk region and a posterior prespore region but, in addition to the coherent mass of prestalk cells that comprises the front one-fifth of the slug, there are Anterior-Like Cells (ALC) scattered throughout the prespore region. Distinct prestalk and ALC subtypes have been identified using ecmA, a gene that encodes an extracellular matrix protein.. ecmA is more strongly expressed in cells in the front of the prestalk region than in the back and cells in these two locations use spatially separated regions of its promoter (Williams et al., 1989; Early et al., 1993). PstA cells occupy the front half of the prestalk region and employ cap-site proximal promoter elements, while pstO cells occupy the rear half and use cap-site distal promoter elements. Although they were initially identified using the bi-partite promoter of the ecmA gene, many other genes are expressed only in one or other region (Maeda et al., 2003). This indicates that ...
The results of the RT-PCR assay and EMSA, shown in this study, have established that Bach2 functions in B cells as a major MARE‐binding factor. In terms of cell differentiation, B cell is the second hematopoietic cell lineage in which partners of MARE‐effectors have been identified, with a precedent being NF‐E2 p45 in erythroid cells (Andrews et al., 1993a, b; Igarashi et al., 1994). This is somewhat surprising in view of our previous observation that, among various hematopoietic cell lines tested, Bach2 expression was detected in the monocytic leukemic cell line M1 but not in BaF3 cells, which are supposed to have a pro‐B status (Oyake et al., 1996). However, in this study we examined Bach2 expression in primary B cells and in a large set of established B‐cell lines, and the results clearly indicate that Bach2 is in fact a B‐cell‐specific factor. The specific deployment of Bach2 in B cells suggests that Bach2 and its interacting bZip proteins are important regulators of B‐cell ...
We report for the first time a novel class of compounds that specifically modulate the Bach1 transcriptional repressor pathway. In cellula, the compounds selectively inhibit the activity of the transcriptional repressor Bach1 resulting in transcription of a network of antioxidant and cytoprotective genes including HMOX1. HPP-1971, a member of this class, is a potent and selective Bach1 inhibitor that induces HMOX1 , 40-fold with a potency of 408 nM in human lung fibroblasts. To assess activity in vivo, we tested HPP-1971 in the Goldblatt model of renovascular hypertension. Sprague Dawley rats were implanted with in dwelling pressure telemeter probes and subsequently underwent sham surgery or placement of a 0.25 mm silver clip around the left renal artery. HPP-1971 treatment, dosed orally at 1,3,10 and 30 mpk, commenced three days following clip surgery, and continued for 18 days. At study completion, blood pressure, clipped kidney weight, renal HMOX1 enzyme activity and plasma aldosterone levels ...
This gene encodes an oncoprotein which is thought to play a role in the phenotypic determination of hemopoetic cells. Translocations between this gene and nucleophosmin have been associated with myelodysplastic syndrome and acute myeloid leukemia. Multiple transcript variants encoding different isoforms have been found for this gene.
Bach Flower Therapy is now available to all clients and patients. We are certified to treat both humans and pets.. Select on the right for more details on why you should choose Bach Flower Therapy, how it can help, what we need from you, pricing, etc. Bach Flower therapy is an alternative treatment that is safe for use with virtually no side effects.. What is Bach Flower Therapy. Bach flower essences are a type of alternative remedy. They are flower essences developed by Dr.Edward Bach to balance physical and emotional disturbances. Dr. Bach believed the right flower essence can help to bring back a patient back to a positive condition and over many years discovered which flower essences aid to resolve a specific set of emotional stresses. Dr. Bach believed that a being incorporates a body of life energy, similar to chi. Flower essences are energetic imprints of the life force of plants. He believed that these flower essences interact with the bodys energies and thus is able to help people with ...
Cottier, F Raymond, M, Kurzai, O, Bolstad, M, Leewattanapasuk, W, Jim nez-L pez, C , Lorenz, MC, Sanglard, D, V chova, L, Pavelka, N, Palkova, Z, M hlschlegel, FA (2012). The bZIP transcription factor Rca1p is a central regulator of a novel CO2 sensing pathway in yeast. PLOS Pathogen 8: e1002485, DOI: 10.1371/journal.ppat. ...
JDP2 bound directly to the ARE core sequence, associated with NFE2L2 and MAFK (NFE2L2-MAFK) via basic leucine zipper domains, and increased DNA-binding activity of the NFE2L2-MAFK complex to the ARE and the transcription of ARE-dependent genes ...
A higher frequency resolution enables a nuclear magnetic resonance tomography (NMR) for individual proteins, as demonstrated by a team led by Jörg Wrachtrup from the Max Planck Institute for Solid State Research and the University of Stuttgart.
The joyful text that is Marys song of praise, "My soul doth magnify the Lord…," is presented in diverse and powerful settings by J.S. Bach and other composers who were influenced by and connected to Bach in various ways. Experience musically the many characteristics from cheerful melodies, colorfully exuberant and festive fanfares, to peaceful and reflective verses.. ON THE PROGRAM. J.S. BACH , Magnificat in D, BWV 243 ...
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Mnt-Max and Myc-Max complex switching on shared target genes. (a) Western blot showing c-Myc expression in wild-type (Mnt+/+) and Mnt (Mnt−/−) MEFs at
Complete information for BZW2 gene (Protein Coding), Basic Leucine Zipper And W2 Domains 2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Complete information for LUZP2 gene (Protein Coding), Leucine Zipper Protein 2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
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Acronyms and Abbreviations ADCC, antibody-dependent cellular cytotoxicity; AID, activation-induced deaminase; BACH2, basic leucine zipper transcription factor 2; BCL-6, B-cell chronic lymphocytic leukemia/lymphoma 6; BiP, immunoglobulin-binding protein; Blimp-1, B-lymphocyte-induced maturation protein-1; BLNK, B-cell linker protein; BTK, Bruton tyrosine kinase; C, constant; CDR, complementarity determining region; CRI, cross-reactive idiotype; CSR, class switch recombination; D, diversity; DLBCL, diffuse large B-cell lymphoma; DNA-PK, DNA protein kinase; E2F1, E2F transcription factor 1; EBF1, early B-cell factor 1; ERGIC, ER-Golgi-intermediate compartment; FR, framework region; H, heavy; HMG, high-mobility group protein; Ig, immunoglobulin; IL, interleukin; IRF4, interferon regulatory factor 4; ITAM, immunoreceptor tyrosine-based activation motif; κ, immunoglobulin kappa light chain; Kde, kappa-deleting element; λ, immunoglobulin lambda light chain; L, light; MITF, microphthalmia-associated ...
Diabetes results from a loss in the capacity of β cells to produce enough insulin to meet the bodys needs, either as a result of autoimmune destruction of β cells (i.e., in type I diabetes mellitus [35]) or of reduced function (i.e., in type II [72]). Here, we have isolated and shown that the MafA transcription factor represents a β-cell-enriched DNA-binding component of the C1/RIPE3b1 activator complex that is involved in cell type-specific and glucose-regulated expression of the insulin gene. MafA is a member of the large Maf family of basic leucine-zipper containing DNA-binding proteins. In addition to MafA, there are three other closely related members of this family-c-Maf, MafB, and NRL-each of which have very similar DNA-binding (basic leucine zipper) and N-terminal transactivation domains (5, 73).. Phosphorylation of conserved serine and threonine residues in the large Maf proteins is important in activation domain function (4). In addition, phosphorylation of a tyrosine(s) appears to ...
Didier Picard, January 2015 Current list of HBD fusion proteins_ Protein X a HBD b regulated as c Refs. transcription factor in Arabidopsis transcription factor Arabidopsis transcription factor in tobacco coactivator transcription factor 1 2 3 transcription factor transcription factor, differentiation factor transcription factor putative transcription factor in arabidposis transcription factor oncoprotein transcription factor transcription factor oncoprotein oncoprotein oncoprotein transcription factor oncoprotein, transcription factor 6 7 transcription factor transcription factor in yeast, tissue culture cells and zebra fish transcriptional repressor transcription factor transcription factor in yeast, in tissue culture cells, transgenic mice, Xenopus, Drosophila and plants transcription factor, promoter of proliferation transcription factor transcription factor 19 20, 21, i Transcription factors APETALA3 ATF6α Athb-1 GR ER e GR Bob1/OBF1 ER e CCAT (from calcium ER e 4 5 channel cav1.2) C/EBP ...
TY - JOUR. T1 - Erratum. T2 - Marek disease virus encodes a basic-leucine zipper gene resembling the fos/jun oncogenes that is highly expressed in lymphoblastoid tumors (Proc. Natl. Acad. Sci. USA (May 1, 1992) 89:9 (4042-4046)). AU - Jones, D.. AU - Lee, L.. AU - Liu, J. L.. AU - Kung, Hsing-Jien. AU - Tillotson, J. K.. PY - 1993. Y1 - 1993. UR - http://www.scopus.com/inward/record.url?scp=0027474633&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0027474633&partnerID=8YFLogxK. M3 - Article. AN - SCOPUS:0027474633. VL - 90. SP - 2556. JO - Proceedings of the National Academy of Sciences of the United States of America. JF - Proceedings of the National Academy of Sciences of the United States of America. SN - 0027-8424. IS - 6. ER - ...
Targeting MYC is a high priority for cancer therapeutics. This is no easy task, as transcription factors are notoriously difficult to inhibit with small molecules, and selectivity is also a hurdle, as MYC oncoproteins heterodimerize with MAX, a requisite and related bHLH‐Zip protein that dimerizes with other bHLH‐Zip proteins (Blackwood & Eisenman, 1991). Finally, achieving a suitable therapeutic window is also a concern, as MYC proteins are required for development and for the growth of normal cell types, where the MYC:MAX complex binds to and directly induces or represses the transcription of a large cast of target genes that harbor CAC/AGTG E‐box elements, which in turn then provoke a proliferative state that amplifies global RNA production (Lin et al, 2012; Nie et al, 2012; Sabo et al, 2014; Walz et al, 2014). Regardless, hope for targeting MYC has recently come from the development of compounds that disrupt the MYC-MAX interaction (Hart et al, 2014), that provoke MYC destruction ...
Author SummaryThere is a highly ordered process by which the parasite Entamoeba histolytica interacts with human cells. Adherence via a parasite lectin is followed in seconds by killing, with only the corpse and not a living cell ingested by the ameba. This process is so central to pathogenesis that clinicians use the presence of ingested erythrocytes to identify E. histolytica and distinguish it from harmless commensal amebae of the gut. We hypothesized that identification of molecules involved in the ingestion of the corpse might provide insight into how amebae cause colitis. We identified a member of the transmembrane kinase family as an early component of the phagosome. Inhibition of this kinase blocked red cell ingestion and prevented amebae from colonizing and invading the gut. There was no impact on dominant-negative parasites to cause liver abscess, suggesting the pathogenesis program differs between anatomic sites. Future studies of the transmembrane kinanse in erythrophagocytosis may provide

Transcriptional Regulation of Metabolic Genes by the Basic Leucine Zipper Transcription Factor Hac1ip and Nutrient Stimuli -...Transcriptional Regulation of Metabolic Genes by the Basic Leucine Zipper Transcription Factor Hac1ip and Nutrient Stimuli -...

Transcriptional Regulation of Metabolic Genes by the Basic Leucine Zipper Transcription Factor Hac1ip and Nutrient Stimuli ... Transcriptional Regulation of Metabolic Genes by the Basic Leucine Zipper Transcription Factor Hac1ip and Nutrient Stimuli. ... A central component of unfolded protein response pathway, the bZIP transcription factor Hac1ip, negatively regulates meiosis ... Regulation of transcription by Ume6p transcriptional regulator, Rpd3p-Sin3p histone deacetylase complex and Isw2p-Itc1p ...
more infohttp://etheses.dur.ac.uk/3415/

sg:pub.10.1038/sj.onc.1201390 - Springer Nature SciGraphsg:pub.10.1038/sj.onc.1201390 - Springer Nature SciGraph

MESH: Basic Helix-Loop-Helix Leucine Zipper Transcription Factors * MESH: Basic-Leucine Zipper Transcription Factors ... "Basic-Leucine Zipper Transcription Factors", "type": "DefinedTerm" }, { "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", " ... "Basic Helix-Loop-Helix Leucine Zipper Transcription Factors", "type": "DefinedTerm" }, { "inDefinedTermSet": "https://www.nlm. ... Basic-Leucine Zipper Transcription Factors 82. ″ rdf:type schema:DefinedTerm 83. N3a47cca8dfb8490bb14c78ae23c55c56 schema: ...
more infohttps://scigraph.springernature.com/pub.10.1038/sj.onc.1201390

BACH2 | SelfDecode | Genome AnalysisBACH2 | SelfDecode | Genome Analysis

... basic leucine zipper transcription facto, BTB and CNC homology 1, basic leucine zipper transcription factor 2, BTB and CNC ... basic leucine zipper transcription factor 2, BTB and CNC-like protein 2, BTB and CNC-like proteiny 1, basic leucine zipper ... Transcription Factor Activity, Sequence-Specific Dna Binding. Biological Processes:. *Transcription From Rna Polymerase Ii ... Transcription regulator protein BACH2, Transcription regulator protein BACH2 (BTB and CNC homolog 2), transcription regulator ...
more infohttps://selfdecode.com/gene/bach2/

Mouse Monoclonal anti-MiTF (Microphthalmia Transcription Factor) (MITF/915) | BiotiumMouse Monoclonal anti-MiTF (Microphthalmia Transcription Factor) (MITF/915) | Biotium

MITF (microphthalmia transcription factor) is a basic helix-loop-helix-leucine-zipper (bHLH-Zip) transcription factor. It ... MITF (microphthalmia transcription factor) is a basic helix-loop-helix-leucine-zipper (bHLH-Zip) transcription factor that ... BHLHE32; Class E basic helix-loop-helix protein 32 (bHLHe32); CMM8; Mi; Microphthalmia-associated transcription factor; MITF; ... Age-resolving osteopetrosis: a rat model implicating microphthalmia and the related transcription factor TFE3. J. Exp.Med. 1998 ...
more infohttps://biotium.com/product/monoclonal-anti-mitf-microphthalmia-transcription-factor-mitf915/

The multiple roles of microRNA-155 in oncogenesis | Journal of Clinical Bioinformatics | Full TextThe multiple roles of microRNA-155 in oncogenesis | Journal of Clinical Bioinformatics | Full Text

MiR-155 also upregulates Mxd1/Mad1, a network of basic helix-loop-helix leucine zipper transcription factors which mediate ... It down-regulates BCL6 (B-cell lymphoma 6) protein [8], which is an evolutionarily conserved zinc finger transcription factor ... It does not bind DNA directly, but attaches through the transcription factors MEF2C and MEF2D. Analysis of DLBCL patient data ... Firstly, miR-155 promotes hk2 transcription by activation of signal transducer and activator of transcription 3 (STAT3), a ...
more infohttps://jclinbioinformatics.biomedcentral.com/articles/10.1186/2043-9113-3-17

Upstream stimulatory factor-2 mediates quercetin-induced suppression of PAI-1 gene expression in human endothelial cells<...Upstream stimulatory factor-2 mediates quercetin-induced suppression of PAI-1 gene expression in human endothelial cells<...

... are platforms for occupancy by several members of the c-MYC family of basic helix-loop-helix leucine zipper (bHLH-LZ) proteins ... keywords = "Endothelial Cells, PAI-1, Proliferation, Transcription Factor, Transfection, USF",. author = "Olave, {N{\e}lida C ... are platforms for occupancy by several members of the c-MYC family of basic helix-loop-helix leucine zipper (bHLH-LZ) proteins ... are platforms for occupancy by several members of the c-MYC family of basic helix-loop-helix leucine zipper (bHLH-LZ) proteins ...
more infohttps://ucdavis.pure.elsevier.com/en/publications/upstream-stimulatory-factor-2-mediates-quercetin-induced-suppress

basic leucine zipper transcription factor Antibodies | Invitrogen
                       
                       
             ...basic leucine zipper transcription factor Antibodies | Invitrogen ...

Antibodies for proteins involved in basic leucine zipper transcription factor pathways, according to their Panther/Gene ... Antibodies for proteins involved in basic leucine zipper transcription factor pathways; according to their Panther/Gene ...
more infohttps://www.thermofisher.com/antibody/primary/panther/basic%20leucine%20zipper%20transcription%20factor

Basic-Leucine Zipper Transcription Factors | Profiles RNSBasic-Leucine Zipper Transcription Factors | Profiles RNS

Basic-Leucine Zipper Transcription Factors*Basic-Leucine Zipper Transcription Factors. *Basic Leucine Zipper Transcription ... "Basic-Leucine Zipper Transcription Factors" by people in this website by year, and whether "Basic-Leucine Zipper Transcription ... "Basic-Leucine Zipper Transcription Factors" is a descriptor in the National Library of Medicines controlled vocabulary ... Below are the most recent publications written about "Basic-Leucine Zipper Transcription Factors" by people in Profiles. ...
more infohttps://profiles.umassmed.edu/display/124780

Arabidopsis basic leucine zipper transcription factors involved in an abscisic acid-dependent signal transduction pathway under...Arabidopsis basic leucine zipper transcription factors involved in an abscisic acid-dependent signal transduction pathway under...

Arabidopsis basic leucine zipper transcription factors involved in an abscisic acid-dependent signal transduction pathway under ... Arabidopsis basic leucine zipper transcription factors involved in an abscisic acid-dependent signal transduction pathway under ... Arabidopsis basic leucine zipper transcription factors involved in an abscisic acid-dependent signal transduction pathway under ... Arabidopsis basic leucine zipper transcription factors involved in an abscisic acid-dependent signal transduction pathway under ...
more infohttps://www.pnas.org/content/97/21/11632?ijkey=2b91c3175333b0a754567c114fbaf34dfdbff311&keytype2=tf_ipsecsha

TCM 006625 - Basic-leucine zipper transcription factor family protein isoform 2 - Theobroma cacao (Cacao) - TCM 006625 gene &...TCM 006625 - Basic-leucine zipper transcription factor family protein isoform 2 - Theobroma cacao (Cacao) - TCM 006625 gene &...

Basic-leucine zipper transcription factor family protein isoform 2Imported. ,p>Information which has been imported from another ... Basic-leucine zipper (BZIP) transcription factor family protein isoform 7 (Fragment). THECC ... Basic-leucine zipper (BZIP) transcription factor family protein isoform 7 (Fragment). THECC ... tr,A0A061E607,A0A061E607_THECC Basic-leucine zipper transcription factor family protein isoform 2 OS=Theobroma cacao OX=3641 GN ...
more infohttps://www.uniprot.org/uniprot/A0A061E607

Genomic Survey and Gene Expression Analysis of the Basic Leucine Zipper Transcription Factor Family in Rice | Plant PhysiologyGenomic Survey and Gene Expression Analysis of the Basic Leucine Zipper Transcription Factor Family in Rice | Plant Physiology

Mallappa C, Yadav V, Negi P, Chattopadhyay S (2006) A basic leucine zipper transcription factor, G-box-binding factor 1, ... The basic Leu zipper (bZIP) transcription factor family is among the largest and most diverse dimerizing transcription factor ... Genomic Survey and Gene Expression Analysis of the Basic Leucine Zipper Transcription Factor Family in Rice. Aashima Nijhawan, ... Genomic Survey and Gene Expression Analysis of the Basic Leucine Zipper Transcription Factor Family in Rice ...
more infohttp://www.plantphysiol.org/content/146/2/333

The Arabidopsis Abscisic Acid Response Gene ABI5 Encodes a Basic Leucine Zipper Transcription Factor | Plant CellThe Arabidopsis Abscisic Acid Response Gene ABI5 Encodes a Basic Leucine Zipper Transcription Factor | Plant Cell

The Arabidopsis Abscisic Acid Response Gene ABI5 Encodes a Basic Leucine Zipper Transcription Factor. Ruth R. Finkelstein, Tim ... The Arabidopsis Abscisic Acid Response Gene ABI5 Encodes a Basic Leucine Zipper Transcription Factor ... The Arabidopsis Abscisic Acid Response Gene ABI5 Encodes a Basic Leucine Zipper Transcription Factor ... The Arabidopsis Abscisic Acid Response Gene ABI5 Encodes a Basic Leucine Zipper Transcription Factor ...
more infohttp://www.plantcell.org/content/12/4/599?ijkey=6acdf03069e465a3032396978bb65843bc434d32&keytype2=tf_ipsecsha

The Arabidopsis Abscisic Acid Response Gene ABI5 Encodes a Basic Leucine Zipper Transcription Factor | Plant CellThe Arabidopsis Abscisic Acid Response Gene ABI5 Encodes a Basic Leucine Zipper Transcription Factor | Plant Cell

The Arabidopsis Abscisic Acid Response Gene ABI5 Encodes a Basic Leucine Zipper Transcription Factor. Ruth R. Finkelstein, Tim ... The Arabidopsis Abscisic Acid Response Gene ABI5 Encodes a Basic Leucine Zipper Transcription Factor ... The Arabidopsis Abscisic Acid Response Gene ABI5 Encodes a Basic Leucine Zipper Transcription Factor ... The Arabidopsis Abscisic Acid Response Gene ABI5 Encodes a Basic Leucine Zipper Transcription Factor ...
more infohttp://www.plantcell.org/content/12/4/599?ijkey=34eba64c70c45ef6170a2f9db47ef9030535c3fc&keytype2=tf_ipsecsha

The Cap n Collar Basic Leucine Zipper Transcription Factor Nrf2 (NF-E2 p45-related Factor 2) Controls Both Constitutive and...The Cap 'n' Collar Basic Leucine Zipper Transcription Factor Nrf2 (NF-E2 p45-related Factor 2) Controls Both Constitutive and...

The Cap n Collar Basic Leucine Zipper Transcription Factor Nrf2 (NF-E2 p45-related Factor 2) Controls Both Constitutive and ... The Cap n Collar Basic Leucine Zipper Transcription Factor Nrf2 (NF-E2 p45-related Factor 2) Controls Both Constitutive and ... The Cap n Collar Basic Leucine Zipper Transcription Factor Nrf2 (NF-E2 p45-related Factor 2) Controls Both Constitutive and ... The Cap n Collar Basic Leucine Zipper Transcription Factor Nrf2 (NF-E2 p45-related Factor 2) Controls Both Constitutive and ...
more infohttp://cancerres.aacrjournals.org/content/61/8/3299?ijkey=f6d9b50c791d61d3c3f5a1c64da58b5283ba5d6b&keytype2=tf_ipsecsha

BACH1 (BTB and CNC homology 1, basic leucine zipper transcription factor 1) - KOMP (Knockout Mouse Project)BACH1 (BTB and CNC homology 1, basic leucine zipper transcription factor 1) - KOMP (Knockout Mouse Project)

BTB and CNC homology 1, basic leucine zipper transcription factor 1. Synonyms: 6230421P05Rik. Gene nomenclature, locus ...
more infohttps://www.komp.org/geneinfo.php?MGI_Number=894680

Antibody Database - Reagents for the antigen BATF / basic leucine zipper transcription factor, ATF-like stained with ...Antibody Database - Reagents for the antigen 'BATF / basic leucine zipper transcription factor, ATF-like' stained with ...

... basic leucine zipper transcription factor, ATF-like stained with Rhodamine in the Antibody Database ... BATF / basic leucine zipper transcription factor, ATF-like Rhodamine Antibodies. Antibodies in the Chromocyte database for BATF ...
more infohttps://www.chromocyte.com/Antibody-Database/Antigen/BATF---basic-leucine-zipper-transcription-factor--ATF-like_4579/Rhodamine_102

Basic helix-loop-helix leucine zipper transcription factors - WikipediaBasic helix-loop-helix leucine zipper transcription factors - Wikipedia

Basic helix-loop-helix leucine zipper transcription factors are, as their name indicates, transcription factors containing both ... Basic helix-loop-helix leucine zipper transcription factors at the US National Library of Medicine Medical Subject Headings ( ... Basic helix-loop-helix and leucine zipper motifs. Examples include Microphthalmia-associated transcription factor and Sterol ...
more infohttps://en.wikipedia.org/wiki/Basic_helix-loop-helix_leucine_zipper_transcription_factors

basic leucine zipper ATF-like transcription factor 2 ELISA Kits | Biocompare.combasic leucine zipper ATF-like transcription factor 2 ELISA Kits | Biocompare.com

Compare basic leucine zipper ATF-like transcription factor 2 ELISA Kits from leading suppliers on Biocompare. View ... basic leucine zipper ATF-like transcription factor 2 ELISA Kits. The ELISA (enzyme-linked immunosorbent assay) is a well- ... Human Basic Leucine Zipper Transcription Factor, ATF-Like 2 (BATF2) ELISA Kit ... Your search returned 16 basic leucine zipper ATF-like transcription factor 2 ELISA ELISA Kit across 3 suppliers. ...
more infohttps://www.biocompare.com/pfu/110627/soids/2-2267179/ELISA_Kit/ELISA_basic_leucine_zipper_ATF-like_transcription_factor_2

Basic leucine zipper transcription factor SlbZIP1 mediates salt and drought stress tolerance in tomato | BMC Plant Biology |...Basic leucine zipper transcription factor SlbZIP1 mediates salt and drought stress tolerance in tomato | BMC Plant Biology |...

... transcription factors perform as crucial regulators in ABA-mediated stress response in plants. Nevertheless, the functions for ... In addition, RNA-seq analysis of transgenic plants revealed that the transcription levels of multiple genes encoding defense ... Basic region/leucine zipper (bZIP) transcription factors perform as crucial regulators in ABA-mediated stress response in ... Yang O, Popova OV, Süthoff U, Lüking I, Dietz KJ, Golldack D. The Arabidopsis basic leucine zipper transcription factor ...
more infohttps://bmcplantbiol.biomedcentral.com/articles/10.1186/s12870-018-1299-0

The basic leucine zipper transcription factor ABSCISIC ACID RESPONSE ELEMENT-BINDING FACTOR2 is an important transcriptional...The basic leucine zipper transcription factor ABSCISIC ACID RESPONSE ELEMENT-BINDING FACTOR2 is an important transcriptional...

The basic leucine zipper transcription factor ABSCISIC ACID RESPONSE ELEMENT-BINDING FACTOR2 is an important transcriptional ... The basic leucine zipper transcription factor ABSCISIC ACID RESPONSE ELEMENT-BINDING FACTOR2 is an important transcriptional ... The basic leucine zipper transcription factor ABSCISIC ACID RESPONSE ELEMENT-BINDING FACTOR2 is an important transcriptional ...
more infohttp://www.metabohub.fr/donnees/publications/the-basic-leucine-zipper-transcription-factor-abscisic-acid-response-element-binding-factor2-is-an-important-transcriptio.html

MacOdrum Library - Carletons Institutional Repository:
  Clade I TGACG-Motif Binding Basic Leucine Zipper Transcription...MacOdrum Library - Carleton's Institutional Repository: Clade I TGACG-Motif Binding Basic Leucine Zipper Transcription...

... basic Leu zipper (bZIP) transcription factors for recruitment to DNA. Here, we show that clade I bZIP transcription factors ... Clade I TGACG-Motif Binding Basic Leucine Zipper Transcription Factors Mediate BLADE-ON-PETIOLE-Dependent Regulation of ... Clade I TGACG-Motif Binding Basic Leucine Zipper Transcription Factors Mediate BLADE-ON-PETIOLE-Dependent Regulation of ... These studies expand the functional repertoire of clade I TGA factors in development and defense. ...
more infohttps://ir.library.carleton.ca/pub/24571

Expression of the Microphthalmia-associated Basic Helix-Loop-Helix Leucine Zipper Transcription Factor Miin Avian Neuroretina...Expression of the Microphthalmia-associated Basic Helix-Loop-Helix Leucine Zipper Transcription Factor Miin Avian Neuroretina...

The mi gene encodes a basic helix-loop-helix leucine zipper transcription factor (Mi) with tissue-restricted expression. To ... Aksan I., Goding C. R. Targeting the microphthalmia basic helix-loop-helix-leucine zipper transcription factor to a subset of E ... Expression of the Microphthalmia-associated Basic Helix-Loop-Helix Leucine Zipper Transcription Factor Miin Avian Neuroretina ... crucial dependence on the Mitf basic-helix-loop-helix-zipper transcription factor. Development (Camb.), 124: 2377-2386, 1997.. ...
more infohttp://cgd.aacrjournals.org/cgi/content/full/10/7/525

KRIBB: PPI1 : a novel pathogen-induced basic region-leucine zipper (bZIP) transcription factor from pepperKRIBB: PPI1 : a novel pathogen-induced basic region-leucine zipper (bZIP) transcription factor from pepper

PPI1 : a novel pathogen-induced basic region-leucine zipper (bZIP) transcription factor from pepper. ... We have isolated a full-length cDNA, PPI1 (pepper-PMMV interaction 1), encoding a novel basic region-leucine zipper (bZIP) DNA- ... Our data provide the first evidence that a bZIP transcription factor is preferentially induced by pathogen attack, suggesting ... leucine zippers; molecular sequence data; plant diseases. ...
more infohttps://repository.kribb.re.kr/handle/201005/5895

Harter | Universität TübingenHarter | Universität Tübingen

The basic region/leucine zipper (bZIP) transcription factors have a basic region that binds DNA and a leucine zipper for homo- ... 3. Basic Leucine-Zipper Transcription Factors. Transcription factors play crucial roles in almost all biological processes and ... ii) Target genes and the post-translational regulation of the Arabidopsis subclass C basic leucine-zipper (bZIP) transcription ... The basic domain contacts the DNA, whereas the leucine zipper mediates protein dimerization (source: www.icm.edu.pl). ...
more infohttps://uni-tuebingen.de/fakultaeten/mathematisch-naturwissenschaftliche-fakultaet/fachbereiche/zentren/zmbp/res/plant-physiology/research-groups/harter.html

CHMP1A - WikipediaCHMP1A - Wikipedia

Involvement of basic leucine zipper transcription factors". The Journal of Biological Chemistry. 273 (50): 33741-9. doi:10.1074 ... "Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins". ... MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor ...
more infohttps://en.wikipedia.org/wiki/CHMP1A
  • Basic features of the multistep two-component system (TCS) predominantly found in higher plants. (uni-tuebingen.de)
  • Similar intron/exon structural patterns were observed in the basic and hinge regions of their bZIP domains. (plantphysiol.org)
  • A Redox-Switchable Molecular Zipper. (bioportfolio.com)
  • The redox-controlled molecular shuttling, which can be likened to the action of a zipper in the macroscopic world, exhibits slow kinetics dampened by the opening and closing of the bifurcated 'tail' of the molecular shuttle. (bioportfolio.com)
  • Several factors regulate Bach2 activity and localization (reviewed in Ref. 2 ), including PI3K signaling in B cells, which leads to phosphorylation of Ser 512 and cytosolic accumulation. (jimmunol.org)
  • These studies expand the functional repertoire of clade I TGA factors in development and defense. (carleton.ca)
  • We found that two NPR1-interacting TGA factors, TGA2 and TGA3, are the principal contributors to an LS7 binding activity of leaves that is enhanced by SA through NPR1. (nih.gov)