AnatomyOrganismsChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
Helix-Loop-Helix MotifsBasic Helix-Loop-Helix Transcription FactorsInhibitor of Differentiation ProteinsHepatocyte Nuclear Factor 3-betaHepatocyte Nuclear Factor 3-gammaHepatocyte Nuclear Factor 3-alphaForkhead Transcription FactorsTranscription FactorsWinged-Helix Transcription FactorsDNA-Binding ProteinsGene Expression Regulation, DevelopmentalMolecular Sequence DataTranscription, GeneticNuclear ProteinsBase SequenceRNA, MessengerCell DifferentiationMice, TransgenicMice, KnockoutPromoter Regions, GeneticT-Lymphocytes, RegulatoryHelix (Snails)Amino Acid SequenceBinding SitesSp1 Transcription FactorGene Expression RegulationProtein BindingTranscriptional ActivationTrans-ActivatorsProtein Structure, SecondaryMutationDNACell LineModels, MolecularProtein Structure, TertiaryRepressor ProteinsTranscription Factor AP-1Signal TransductionHomeodomain ProteinsBasic-Leucine Zipper Transcription FactorsTransfectionCell NucleusTranscription Factor AP-2Transcription Factors, TFIIKruppel-Like Transcription FactorsHeLa CellsGenes, ReporterSequence Homology, Amino AcidCells, CulturedNucleic Acid ConformationChromatin ImmunoprecipitationRecombinant Fusion ProteinsCloning, MolecularYY1 Transcription FactorSTAT3 Transcription FactorTranscription Factor TFIIDGATA4 Transcription FactorPlasmidsMutagenesis, Site-DirectedZinc FingersActivating Transcription Factor 3Reverse Transcriptase Polymerase Chain ReactionNFATC Transcription Factors
Helix-Loop-Helix Motifs
Recurring supersecondary structures characterized by 20 amino acids folding into two alpha helices connected by a non-helical "loop" segment. They are found in many sequence-specific DNA-BINDING PROTEINS and in CALCIUM-BINDING PROTEINS.
Basic Helix-Loop-Helix Transcription Factors
A family of DNA-binding transcription factors that contain a basic HELIX-LOOP-HELIX MOTIF.
Inhibitor of Differentiation Proteins
Inhibitor of differentiation proteins are negative regulators of BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS. They inhibit CELL DIFFERENTIATION and induce CELL PROLIFERATION by modulating different CELL CYCLE regulators.
Hepatocyte Nuclear Factor 3-beta
A forkhead transcription factor that regulates expression of metabolic GENES and is involved in EMBRYONIC DEVELOPMENT. Mutations in HNF-3beta have been associated with CONGENITAL HYPERINSULINISM.
Hepatocyte Nuclear Factor 3-gamma
A winged-helix transcription factor that regulates GENE expression in metabolic tissues. It plays a role in HOMEOSTASIS of GLUCOSE and controls expression of GLUT2 PROTEIN.
Hepatocyte Nuclear Factor 3-alpha
A forkhead transcription factor that is an essential activator of GLUCAGON gene expression.
Forkhead Transcription Factors
A subclass of winged helix DNA-binding proteins that share homology with their founding member fork head protein, Drosophila.
Transcription Factors
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
Winged-Helix Transcription Factors
A subfamily of HELIX-TURN-HELIX DNA-binding proteins that contain a variable length loop adjacent to the HTH motif. The loop connects two anti-parallel strands and forms a wing when bound to DNA.
DNA-Binding Proteins
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
Gene Expression Regulation, Developmental
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Transcription, Genetic
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
Nuclear Proteins
Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.
Base Sequence
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Cell Differentiation
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
Mice, Transgenic
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
Mice, Knockout
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Promoter Regions, Genetic
DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.
T-Lymphocytes, Regulatory
CD4-positive T cells that inhibit immunopathology or autoimmune disease in vivo. They inhibit the immune response by influencing the activity of other cell types. Regulatory T-cells include naturally occurring CD4+CD25+ cells, IL-10 secreting Tr1 cells, and Th3 cells.
Helix (Snails)
A genus of chiefly Eurasian and African land snails including the principal edible snails as well as several pests of cultivated plants.
Amino Acid Sequence
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Binding Sites
The parts of a macromolecule that directly participate in its specific combination with another molecule.
Sp1 Transcription Factor
Promoter-specific RNA polymerase II transcription factor that binds to the GC box, one of the upstream promoter elements, in mammalian cells. The binding of Sp1 is necessary for the initiation of transcription in the promoters of a variety of cellular and viral GENES.
Gene Expression Regulation
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
Protein Binding
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
Transcriptional Activation
Processes that stimulate the GENETIC TRANSCRIPTION of a gene or set of genes.
Trans-Activators
Diffusible gene products that act on homologous or heterologous molecules of viral or cellular DNA to regulate the expression of proteins.
Protein Structure, Secondary
The level of protein structure in which regular hydrogen-bond interactions within contiguous stretches of polypeptide chain give rise to alpha helices, beta strands (which align to form beta sheets) or other types of coils. This is the first folding level of protein conformation.
Mutation
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
DNA
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Cell Line
Established cell cultures that have the potential to propagate indefinitely.
Models, Molecular
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
Protein Structure, Tertiary
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
Repressor Proteins
Proteins which maintain the transcriptional quiescence of specific GENES or OPERONS. Classical repressor proteins are DNA-binding proteins that are normally bound to the OPERATOR REGION of an operon, or the ENHANCER SEQUENCES of a gene until a signal occurs that causes their release.
Transcription Factor AP-1
A multiprotein complex composed of the products of c-jun and c-fos proto-oncogenes. These proteins must dimerize in order to bind to the AP-1 recognition site, also known as the TPA-responsive element (TRE). AP-1 controls both basal and inducible transcription of several genes.
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Homeodomain Proteins
Proteins encoded by homeobox genes (GENES, HOMEOBOX) that exhibit structural similarity to certain prokaryotic and eukaryotic DNA-binding proteins. Homeodomain proteins are involved in the control of gene expression during morphogenesis and development (GENE EXPRESSION REGULATION, DEVELOPMENTAL).
Basic-Leucine Zipper Transcription Factors
A large superfamily of transcription factors that contain a region rich in BASIC AMINO ACID residues followed by a LEUCINE ZIPPER domain.
Transfection
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
Cell Nucleus
Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
Transcription Factor AP-2
A family of DNA binding proteins that regulate expression of a variety of GENES during CELL DIFFERENTIATION and APOPTOSIS. Family members contain a highly conserved carboxy-terminal basic HELIX-TURN-HELIX MOTIF involved in dimerization and sequence-specific DNA binding.
Transcription Factors, TFII
The so-called general transcription factors that bind to RNA POLYMERASE II and that are required to initiate transcription. They include TFIIA; TFIIB; TFIID; TFIIE; TFIIF; TFIIH; TFII-I; and TFIIJ. In vivo they apparently bind in an ordered multi-step process and/or may form a large preinitiation complex called RNA polymerase II holoenzyme.
Kruppel-Like Transcription Factors
A family of zinc finger transcription factors that share homology with Kruppel protein, Drosophila. They contain a highly conserved seven amino acid spacer sequence in between their ZINC FINGER MOTIFS.
HeLa Cells
The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.
Genes, Reporter
Genes whose expression is easily detectable and therefore used to study promoter activity at many positions in a target genome. In recombinant DNA technology, these genes may be attached to a promoter region of interest.
Sequence Homology, Amino Acid
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
Cells, Cultured
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Nucleic Acid Conformation
The spatial arrangement of the atoms of a nucleic acid or polynucleotide that results in its characteristic 3-dimensional shape.
Chromatin Immunoprecipitation
A technique for identifying specific DNA sequences that are bound, in vivo, to proteins of interest. It involves formaldehyde fixation of CHROMATIN to crosslink the DNA-BINDING PROTEINS to the DNA. After shearing the DNA into small fragments, specific DNA-protein complexes are isolated by immunoprecipitation with protein-specific ANTIBODIES. Then, the DNA isolated from the complex can be identified by PCR amplification and sequencing.
Recombinant Fusion Proteins
Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.
Cloning, Molecular
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
YY1 Transcription Factor
A ubiquitously expressed zinc finger-containing protein that acts both as a repressor and activator of transcription. It interacts with key regulatory proteins such as TATA-BINDING PROTEIN; TFIIB; and ADENOVIRUS E1A PROTEINS.
STAT3 Transcription Factor
A signal transducer and activator of transcription that mediates cellular responses to INTERLEUKIN-6 family members. STAT3 is constitutively activated in a variety of TUMORS and is a major downstream transducer for the CYTOKINE RECEPTOR GP130.
Transcription Factor TFIID
The major sequence-specific DNA-binding component involved in the activation of transcription of RNA POLYMERASE II. It was originally described as a complex of TATA-BOX BINDING PROTEIN and TATA-BINDING PROTEIN ASSOCIATED FACTORS. It is now know that TATA BOX BINDING PROTEIN-LIKE PROTEINS may take the place of TATA-box binding protein in the complex.
GATA4 Transcription Factor
A GATA transcription factor that is expressed in the MYOCARDIUM of developing heart and has been implicated in the differentiation of CARDIAC MYOCYTES. GATA4 is activated by PHOSPHORYLATION and regulates transcription of cardiac-specific genes.
Plasmids
Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.
Mutagenesis, Site-Directed
Genetically engineered MUTAGENESIS at a specific site in the DNA molecule that introduces a base substitution, or an insertion or deletion.
Zinc Fingers
Motifs in DNA- and RNA-binding proteins whose amino acids are folded into a single structural unit around a zinc atom. In the classic zinc finger, one zinc atom is bound to two cysteines and two histidines. In between the cysteines and histidines are 12 residues which form a DNA binding fingertip. By variations in the composition of the sequences in the fingertip and the number and spacing of tandem repeats of the motif, zinc fingers can form a large number of different sequence specific binding sites.
Activating Transcription Factor 3
An activating transcription factor that plays a key role in cellular responses to GENOTOXIC STRESS and OXIDATIVE STRESS.
Reverse Transcriptase Polymerase Chain Reaction
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
NFATC Transcription Factors
A family of transcription factors characterized by the presence of highly conserved calcineurin- and DNA-binding domains. NFAT proteins are activated in the CYTOPLASM by the calcium-dependent phosphatase CALCINEURIN. They transduce calcium signals to the nucleus where they can interact with TRANSCRIPTION FACTOR AP-1 or NF-KAPPA B and initiate GENETIC TRANSCRIPTION of GENES involved in CELL DIFFERENTIATION and development. NFAT proteins stimulate T-CELL activation through the induction of IMMEDIATE-EARLY GENES such as INTERLEUKIN-2.

A conserved motif in goosecoid mediates groucho-dependent repression in Drosophila embryos. (1/5432)

Surprisingly small peptide motifs can confer critical biological functions. One example is the WRPW tetrapeptide present in the Hairy family of transcriptional repressors, which mediates recruitment of the Groucho (Gro) corepressor to target promoters. We recently showed that Engrailed (En) is another repressor that requires association with Gro for its function. En lacks a WRPW motif; instead, it contains another short conserved sequence, the En homology region 1 (eh1)/GEH motif, that is likely to play a role in tethering Gro to the promoter. Here, we characterize a repressor domain from the Goosecoid (Gsc) developmental regulator that includes an eh1/GEH-like motif. We demonstrate that this domain (GscR) mediates efficient repression in Drosophila blastoderm embryos and that repression by GscR requires Gro function. GscR and Gro interact in vitro, and the eh1/GEH motif is necessary and sufficient for the interaction and for in vivo repression. Because WRPW- and eh1/GEH-like motifs are present in different proteins and in many organisms, the results suggest that interactions between short peptides and Gro represent a widespread mechanism of repression. Finally, we investigate whether Gro is part of a stable multiprotein complex in the nucleus. Our results indicate that Gro does not form stable associations with other proteins but that it may be able to assemble into homomultimeric complexes.  (+info)

Physical interaction of the bHLH LYL1 protein and NF-kappaB1 p105. (2/5432)

The LYL1 gene was first identified upon the molecular characterization of the t(7;9)(q35;p13) translocation associated with some human T-cell acute leukemias (T-ALLs). In adult tissues, LYL1 expression is restricted to hematopoietic cells with the notable exclusion of the T cell lineage. LYL1 encodes a basic helix-loop-helix (bHLH) protein highly related to TAL-1, whose activation is also associated with a high proportion of human T-ALLs. A yeast two-hybrid system was used to identify proteins that specifically interact with LYL1 and might mediate its activities. We found that p105, the precursor of NF-kappaB1 p50, was the major LYL1-interacting protein in this system. The association between LYL1 and p105 was confirmed both in vitro and in vivo in mammalian cells. Biochemical studies indicated that the interaction was mediated by the bHLH motif of LYL1 and the ankyrin-like motifs of p105. Ectopic expression of LYL1 in a human T cell line caused a significant decrease in NF-kappaB-dependent transcription, associated with a reduced level of NF-kappaB1 proteins.  (+info)

A molecular pathway revealing a genetic basis for human cardiac and craniofacial defects. (3/5432)

Microdeletions of chromosome 22q11 are the most common genetic defects associated with cardiac and craniofacial anomalies in humans. A screen for mouse genes dependent on dHAND, a transcription factor implicated in neural crest development, identified Ufd1, which maps to human 22q11 and encodes a protein involved in degradation of ubiquitinated proteins. Mouse Ufd1 was specifically expressed in most tissues affected in patients with 22q11 deletion syndrome. The human UFD1L gene was deleted in all 182 patients studied with 22q11 deletion, and a smaller deletion of approximately 20 kilobases that removed exons 1 to 3 of UFD1L was found in one individual with features typical of 22q11 deletion syndrome. These data suggest that UFD1L haploinsufficiency contributes to the congenital heart and craniofacial defects seen in 22q11 deletion.  (+info)

Expression of Mash1 in basal cells of rat circumvallate taste buds is dependent upon gustatory innervation. (4/5432)

Mash1, a mammalian homologue of the Drosophila achaete-scute proneural gene complex, plays an essential role in differentiation of subsets of peripheral neurons. In this study, using RT-PCR and in situ RT-PCR, we investigated if Mash1 gene expression occurs in rat taste buds. Further, we examined dynamics of Mash1 expression in the process of degeneration and regeneration in denervated rat taste buds. In rat tongue epithelium, Mash1 gene expression is confined to circumvallate, foliate, and fungiform papilla epithelia that include taste buds. In taste buds, Mash1-expressing cells are round cells in the basal compartment. In contrast, the mature taste bud cells do not express the Mash1 gene. Denervation and regeneration experiments show that the expression of Mash1 requires gustatory innervation. We conclude that Mash1 is expressed in cells of the taste bud lineage, and that the expression of Mash1 in rat taste buds is dependent upon gustatory innervation.  (+info)

Dynamic expression of lunatic fringe suggests a link between notch signaling and an autonomous cellular oscillator driving somite segmentation. (5/5432)

The metameric organization of the vertebrate trunk is a characteristic feature of all members of this phylum. The origin of this metamerism can be traced to the division of paraxial mesoderm into individual units, termed somites, during embryonic development. Despite the identification of somites as the first overt sign of segmentation in vertebrates well over 100 years ago, the mechanism(s) underlying somite formation remain poorly understood. Recently, however, several genes have been identified which play prominent roles in orchestrating segmentation, including the novel secreted factor lunatic fringe. To gain further insight into the mechanism by which lunatic fringe controls somite development, we have conducted a thorough analysis of lunatic fringe expression in the unsegmented paraxial mesoderm of chick embryos. Here we report that lunatic fringe is expressed predominantly in somite -II, where somite I corresponds to the most recently formed somite and somite -I corresponds to the group of cells which will form the next somite. In addition, we show that lunatic fringe is expressed in a highly dynamic manner in the chick segmental plate prior to somite formation and that lunatic fringe expression cycles autonomously with a periodicity of somite formation. Moreover, the murine ortholog of lunatic fringe undergoes a similar cycling expression pattern in the presomitic mesoderm of somite stage mouse embryos. The demonstration of a dynamic periodic expression pattern suggests that lunatic fringe may function to integrate notch signaling to a cellular oscillator controlling somite segmentation.  (+info)

The development and evolution of bristle patterns in Diptera. (6/5432)

The spatial distribution of sensory bristles on the notum of different species of Diptera is compared. Species displaying ancestral features have a simple organization of randomly distributed, but uniformly spaced, bristles, whereas species thought to be more derived bear patterns in which the bristles are aligned into longitudinal rows. The number of rows of large bristles on the scutum was probably restricted to four early on in the evolution of cyclorraphous Brachyceran flies. Most species have stereotyped patterns based on modifications of these four rows. The possible constraints placed upon the patterning mechanisms due to growth and moulting within the Diptera are discussed, as well as within hemimetabolous insects. The holometabolic life cycle and the setting aside of groups of imaginal cells whose function is not required during the growth period, may have provided the freedom necessary for the evolution of elaborate bristle patterns. We briefly review the current state of knowledge concerning the complex genetic pathways regulating achaete-scute gene expression and bristle pattern in Drosophila melanogaster, and consider mechanisms for the genetic regulation of the bristle patterns of other species of Diptera.  (+info)

Bar homeobox genes are latitudinal prepattern genes in the developing Drosophila notum whose expression is regulated by the concerted functions of decapentaplegic and wingless. (7/5432)

In Drosophila notum, the expression of achaete-scute proneural genes and bristle formation have been shown to be regulated by putative prepattern genes expressed longitudinally. Here, we show that two homeobox genes at the Bar locus (BarH1 and BarH2) may belong to a different class of prepattern genes expressed latitudinally, and suggest that the developing notum consists of checker-square-like subdomains, each governed by a different combination of prepattern genes. BarH1 and BarH2 are coexpressed in the anterior-most notal region and regulate the formation of microchaetae within the region of BarH1/BarH2 expression through activating achaete-scute. Presutural macrochaetae formation also requires Bar homeobox gene activity. Bar homeobox gene expression is restricted dorsally and posteriorly by Decapentaplegic signaling, while the ventral limit of the expression domain of Bar homeobox genes is determined by wingless whose expression is under the control of Decapentaplegic signaling.  (+info)

Dual role of extramacrochaetae in cell proliferation and cell differentiation during wing morphogenesis in Drosophila. (8/5432)

The Extramacrochaetae (emc) gene encodes a transcription factor with an HLH domain without the basic region involved in interaction with DNA present in other proteins that have this domain. EMC forms heterodimers with bHLH proteins preventing their binding to DNA, acting as a negative regulator. The function of emc is required in many developmental processes during the development of Drosophila, including wing morphogenesis. Mitotic recombination clones of both null and gain-of-function alleles of emc, indicate that during wing morphogenesis, emc participates in cell proliferation within the intervein regions (vein patterning), as well as in vein differentiation. The study of relationships between emc and different genes involved in wing development reveal strong genetic interactions with genes of the Ras signalling pathway (torpedo, vein, veinlet and Gap), blistered, plexus and net, in both adult wing phenotypes and cell behaviour in genetic mosaics. These interactions are also analyzed as variations of emc expression patterns in mutant backgrounds for these genes. In addition, cell proliferation behaviour of emc mutant cells varies depending on the mutant background. The results show that genes of the Ras signalling pathway are co-operatively involved in the activity of emc during cell proliferation, and later antagonistically during cell differentiation, repressing EMC expression.  (+info)

Genome-wide analysis of basic/helix-loop-helix transcription factor family in rice and Arabidopsis<...
TY - JOUR. T1 - Genome-wide analysis of basic/helix-loop-helix transcription factor family in rice and Arabidopsis. AU - Li, Xiaoxing. AU - Duan, Xuepeng. AU - Jiang, Haixiong. AU - Sun, Yujin. AU - Tang, Yuanping. AU - Yuan, Zheng. AU - Guo, Jingkang. AU - Liang, Wanqi. AU - Chen, Liang. AU - Yin, Jingyuan. AU - Ma, Hong. AU - Wang, Jian. AU - Zhang, Dabing. PY - 2006/8. Y1 - 2006/8. N2 - The basic/helix-loop-helix (bHLH) transcription factors and their homologs form a large family in plant and animal genomes. They are known to play important roles in the specification of tissue types in animals. On the other hand, few plant bHLH proteins have been studied functionally. Recent completion of whole genome sequences of model plants Arabidopsis (Arabidopsis thaliana) and rice (Oryza sativa) allows genome-wide analysis and comparison of the bHLH family in flowering plants. We have identified 167 bHLH genes in the rice genome, and their phylogenetic analysis indicates that they form well-supported ...
https://pennstate.pure.elsevier.com/en/publications/genome-wide-analysis-of-basichelix-loop-helix-transcription-facto
The basic helix-loop-helix transcription factor neuroD is expressed in the rod lineage of the teleost retina. - PubMed - NCBIThe basic helix-loop-helix transcription factor neuroD is expressed in the rod lineage of the teleost retina. - PubMed - NCBI
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Kakuk-Atkins+L%5Bau%5D&dispmax=50
Proneural genetic programs include genes required for asymmetric cell division in drosophilaProneural genetic programs include genes required for asymmetric cell division in drosophila
Author(s): Reeves, Nick Lee | Abstract: In 1975 Antonio García-Bellido proposed that selector genes such as the homeotic transcription factors do not themselves participate in the differentiation of the body segments they specify but instead activate (or select) a set of downstream realisator genes that encode the proteins that carry out cell differentiation (Garcia- Bellido, 1975). Since then numerous genetic and molecular studies of development have borne out this view. The proneural transcription factors act as selector genes to specify neural cell types in the ectoderm. I have taken a systematic genomics approach to discover the set of realisator genes activated by the proneural transcription factors (proneural genetic program) in the developing peripheral nervous system. This approach has led to the discovery of 30 new genes expressed specifically in the sensory organ anlagen (proneural clusters and sensory organ precursors). These new genes encode a diverse array of implied protein functions
https://escholarship.org/uc/item/6ng2m7xk
The bHLH transcription factor hand2 is essential for noradrenergic differentiation of sympathetic neurons | DevelopmentThe bHLH transcription factor hand2 is essential for noradrenergic differentiation of sympathetic neurons | Development
Hand2 has no effect on the initial stages of sympathetic neuron development, including the expression of the proneural gene ascl1 and the pan-autonomic regulatory genes phox2b and phox2a, nor on generic neuronal differentiation as assessed by the expression of elavl3. Therefore, hand2 seems to be required selectively for initial noradrenergic but not pan-neuronal differentiation.. Hand2 has been considered an important member of the transcriptional network controlling sympathetic neuron development due to its ability to induce the generation of noradrenergic/catecholaminergic neurons in gain-of-function experiments (Howard et al., 1999; Howard et al., 2000). Overexpression is an important tool to identify candidate target genes, but in the sympathetic lineage different effects were observed upon transcription factor overexpression compared with in vivo loss-of-function approaches. Gata2/3, for instance, is essential for Th expression during normal development of sympathetic neurons but has ...
http://dev.biologists.org/content/133/20/4015
Phosphorylation in intrinsically disordered regions regulates the activity of Neurogenin2. - Tufts Digital...
Background: Neuronal differentiation is largely under the control of basic Helix-Loop-Helix (bHLH) proneural transcription factors that play key roles during development of the embryonic nervous system. In addition to well-characterised regulation of their expression, increasing evidence is emerging for additional post-translational regul... read moreation of proneural protein activity. Of particular interest is the bHLH proneural factor Neurogenin2 (Ngn2), which orchestrates progression from neural progenitor to differentiated neuron in several regions of the central nervous system. Previous studies have demonstrated a key role for cell cycle-dependent multi-site phosphorylation of Ngn2 protein at Serine-Proline (SP) sites for regulation of its neuronal differentiation activity, although the potential structural and functional consequences of phosphorylation at different regions of the protein are unclear. read less. ...
https://dl.tufts.edu/catalog/tufts:17305
Examination of mammalian basic helix-loop-helix transcription factors using a yeast one-hybrid systemExamination of mammalian basic helix-loop-helix transcription factors using a yeast one-hybrid system
Basic helix-loop-helix (bHLH) transcription factors play diverse roles in controlling many developmental events. Although a great deal is understood about how bHLH factors activate gene transcription via E-box DNA consensus sequences, studies of bHLH factor function in higher eukaryotes often have b …
https://pubmed.ncbi.nlm.nih.gov/8561893/
JAIRO | Conformational changes in inhibitory PAS domain protein associated with binding of HIF-1α and Bcl-xL in living cells.
Conformational changes in inhibitory PAS domain protein associated with binding of HIF-1α and Bcl-xL in living cells.Conformational changes in inhibitory PAS domain protein associated with binding of HIF-1α and Bcl-xL in living cells. ...
http://jairo.nii.ac.jp/0083/00255319/en
Neurogenin-3 - WikipediaNeurogenin-3 - Wikipedia
Neurogenin-3 is a protein that in humans is encoded by the NEUROG3 gene.[5]. Neurogenin-3 is expressed in endocrine progenitor cells and is required for endocrine cell development in the pancreas and intestine.[6] It belongs to a family of basic helix-loop-helix (bHLH) transcription factors involved in the determination of neural precursor cells in the neuroectoderm.[7]. Neurogenin 3 (NGN3) is expressed by 2-10% of acinar and duct cells in the histologically normal adult human pancreas. NGN3+ cells isolated from cultured exocrine tissue by coexpressed cell surface glycoprotein CD133 have a transcriptome consistent with exocrine dedifferentiation, a phenotype that resembles endocrine progenitor cells during development, and a capacity for endocrine differentiation in vitro.[8] Human[9] and rodent[10][11][12][13][14][15][16][17][18] exocrine cells have been reprogrammed into cells with an islet cell-like phenotype following direct expression of NGN3 or manipulation that leads to its ...
https://en.wikipedia.org/wiki/NEUROG3
HIF1A - Hypoxia inducible factor 1, alpha subunit (Basic helix-loop-helix transcription factor) - Bos taurus (Bovine) - HIF1A...HIF1A - Hypoxia inducible factor 1, alpha subunit (Basic helix-loop-helix transcription factor) - Bos taurus (Bovine) - HIF1A...
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
http://www.uniprot.org/uniprot/A0JND0
Distinct domains within Mash1 and Math1 are required for function in neuronal differentiation versus neuronal cell-type...Distinct domains within Mash1 and Math1 are required for function in neuronal differentiation versus neuronal cell-type...
Basic helix-loop-helix (bHLH) transcription factors are required for proper formation of the vertebrate and invertebrate nervous systems (Bertrand et al., 2002). The vertebrate neural bHLH transcription factors have been classified into subgroups based on their temporal pattern of expression (Lee, 1997) and on their homology to Drosophila proneural genes (Bertrand et al., 2002). The factors Mash1, a homolog of the Drosophila Achaete-scute genes (Johnson et al., 1990), and Math1, a homolog of the Drosophila atonal gene (Akazawa et al., 1995), both belong to the early expressed sub-group of bHLH factors because of their expression in progenitor cells of the developing neural tube, but they reside in distinct sub-classes based on sequence homology (Bertrand et al., 2002). Gene knockout studies have demonstrated essential roles for these factors in the formation of specific populations of neurons (Ben-Arie et al., 1997; Bermingham et al., 1999; Bermingham et al., 2001; Fode et al., 2000; Gowan et ...
http://dev.biologists.org/content/131/6/1319
endothelial PAS domain-containing protein 1 Summary Report | CureHunterendothelial PAS domain-containing protein 1 Summary Report | CureHunter
endothelial PAS domain-containing protein 1: a Per-Arnt/AhR-Sim basic helix-loop-helix factor similar to hypoxia-inducible factor 1alpha; RefSeq NM_010137 (mouse); do not confuse with hepatic leukemia factor
http://www.curehunter.com/public/keywordSummaryC105713-endothelial-PAS-domain-containing-protein-1.do
Pro-Photoreceptor Activity of Chick neurogenin1 | IOVS | ARVO JournalsPro-Photoreceptor Activity of Chick neurogenin1 | IOVS | ARVO Journals
Proneural bHLH genes have been shown to play important roles in specifying neural fates/diversities in both the central nervous system and the peripheral nervous system. The developing vertebrate retina expresses several such genes, such as achaete-scute homologue 1 (ash1), atonal homologue 3 (ath3), ath5, neuroD, neurogenin1 (ngn1), ngn2, ngn3, NSCL1, and NSCL2. Proneural bHLH genes known to be expressed in retinal progenitor cells include ash1, ath3, ngn1, ngn2, and ngn3. 16-21 Analysis of retinal explants derived from ash1-null mice indicated that ash1 participates in the production of late-born neurons, including rod photoreceptors and bipolar cells. 22 In the chick retina, ash1 was proposed to promote amacrine cells, 23 and this was later confirmed experimentally. 24 Studies have indicated ath3 in the production of bipolar and amacrine cells. 25-27 Ngn2 is expressed in the proliferating zone, 25,28 including cells still in the cell cycle. 29,30 In the mouse retina, regions lacking ngn2 ...
http://iovs.arvojournals.org/article.aspx?articleid=2184892
ATOH1 - ويكيبيدياATOH1 - ويكيبيديا
Westerman BA, Breuer RH, Poutsma A, Chhatta A, Noorduyn LA, Koolen MG, Postmus PE, Blankenstein MA, Oudejans CB (2007). Basic helix-loop-helix transcription factor profiling of lung tumors shows aberrant expression of the proneural gene atonal homolog 1 (ATOH1, HATH1, MATH1) in neuroendocrine tumors. The International Journal of Biological Markers. 22 (2): 114-23. PMID 17549667 ...
https://ar.wikipedia.org/wiki/ATOH1
Mammalian BarH homologue is a potential regulator of neural bHLH genes.
Vertebrate neurogenesis involves sequential actions of transcription factors. neurogenins, encoding Atonal-related bHLH transcription factors, function as neuronal determination genes in Xenopus. neurogenins and antother bHLH factor gene, Mash1, are expressed in distinct subsets or areas of cells giving rise to neurons, suggesting that these genes play important roles to generate distinct populations of neurons. A mammalian homologue of BarH (MBH1) is expressed in a complementary pattern to Mash1 expression in the developing nervous system like neurogenins. Forced expression of MBH1 down-regulates expression of Mash1 and up-regulates neurogenin2/Math4A, a member of neurogenins, in P19 cells during neuronal differentiation. This suggests that MBH1 is a potential regulator of mammalian neural bHLH genes, thereby establishing distinct pathways of neuronal differentiation ...
http://vivo.mblwhoilibrary.org/display/publication71300
Abstract 14: The Helix-Loop-Helix Transcription Factor nPAS4 Induces Sprouting Angiogenesis and Regulates Tip Cell Formation |...Abstract 14: The Helix-Loop-Helix Transcription Factor nPAS4 Induces Sprouting Angiogenesis and Regulates Tip Cell Formation |...
Introduction: Neuronal PAS4 (nPAS4) -formerly known as LE-PAS- is a helix-loop-helix-PAS (HLH-PAS) transcription factor that has recently been cloned as the vertebrate homologue of the drosophila protein dysfusion (dys). In drosophila, the lack of dys is characterized by impaired midline fusion of tracheal tubes. Forced expression of dys results in aberrant sprouting of tracheal tubes in drosophila. In neurons, nPAS4 plays a role in the formation of GABA-releasing synapses. Based on the morphological similarity between tracheal tube formation and angiogenesis, we aimed to investigate the role of nPAS4 in angiogenesis in vertebrates.. Methods and Results: RT-PCR and Western blotting analyses showed that nPAS4 is expressed at low levels in various endothelial cell lines. The expression of nPAS4 is not upregulated by angiogenic growth factors but is induced by hypoxia. Moreover, membrane depolarization using potassium chloride results in a calcium-dependent upregulation of nPAS4. When nPAS4 ...
http://atvb.ahajournals.org/content/32/Suppl_1/A14
Genetic risk expressed in early regulator of gene expression | Genes 2 Brains 2 Mind 2 MeGenetic risk expressed in early regulator of gene expression | Genes 2 Brains 2 Mind 2 Me
Image via Wikipedia The basic helix-loop-helix transcription factor, neurogenin-1 is known to regulate neural development and neurite outgrowth. As such, it makes for a particularly interesting point to begin to understand mental illness and its complex developmental origins. The recent paper by Ho et al., Basic helix-loop-helix transcription factor NEUROG1 and schizophrenia: Effects on illness…
https://genes2brains2mind2me.com/2009/06/29/genetic-risk-expressed-in-early-regulator-of-gene-expression/
Proneural genes - WikipediaProneural genes - Wikipedia
Proneural genes encode transcription factors of the basic helix-loop-helix (bHLH) class which are responsible for the development of neuroectodermal progenitor cells. Proneural genes have multiple functions in neural development. They integrate positional information and contribute to the specification of progenitor-cell identity. From the same ectodermal cell types, neural or epidermal cells can develop based on interactions between proneural and neurogenic genes. Neurogenic genes are so called because loss of function mutants show an increase number of developed neural precursors. On the other hand, proneural genes mutants fail to develop neural precursor cells. The proneural genes are expressed in groups of cells (proneural clusters) from which one progenitor cell - typically the one in the middle - will be singled out, leading to the formation of many different types of neurons in the central and peripheral nervous systems. Proneural genes encode a group of bHLH proteins that play crucial ...
https://en.wikipedia.org/wiki/Proneural_genes
Transcription Factor 3 Summary Report | CureHunterTranscription Factor 3 Summary Report | CureHunter
Transcription Factor 3: A basic helix-loop-helix transcription factor that plays a role in determining cell fate during embryogenesis. It forms a heterodimer with TWIST TRANSCRIPTION FACTOR and ACHAETE-SCUTE GENE COMPLEX-related TRANSCRIPTION FACTORS.
http://www.curehunter.com/public/keywordSummaryD058127-Transcription-Factor-3.do
The bHLH factors, dHAND and eHAND, specify pulmonary and systemic cardiac ventricles independent of left-right sidednessThe bHLH factors, dHAND and eHAND, specify pulmonary and systemic cardiac ventricles independent of left-right sidedness
dHAND and eHAND are basic helix-loop-helix transcription factors that play critical roles in cardiac development. The HAND genes have a complementary left-right cardiac asymmetry of expression with dHAND predominantly on the right side and eHAND on the left side of the looped heart tube. Here we sho …
https://pubmed.ncbi.nlm.nih.gov/9576835/
HEA798Hu | 低氧诱导因子1α(HIF1a)检测试剂盒(酶联免疫吸附试验法,高敏型) | Homo sapiens (Human，人) USCN(武汉优尔生商贸有限公司)HEA798Hu | 低氧诱导因子1α(HIF1a)检测试剂盒(酶联免疫吸附试验法,高敏型) | Homo sapiens (Human，人) USCN(武汉优尔生商贸有限公司)
HEA798Hu, High Sensitive ELISA Kit for Hypoxia Inducible Factor 1 Alpha (HIF1a), 低氧诱导因子1α(HIF1a)检测试剂盒(酶联免疫吸附试验法,高敏型), HIF1-A; MOP1; PASD8; Basic Helix-Loop-Helix Transcription Factor; ARNT-interacting protein; Basic-helix-loop-helix-PAS protein MOP1; Class E basic helix-loop-helix protein 78 | 仅供体外研究使用，不用于临床诊断！请索取进口关税税单及报关单！
http://www.uscnk.cn/uscn/High-Sensitive-ELISA-Kit-for-Hypoxia-Inducible-Factor-1-Alpha-
Differential genomic targeting of the transcription factor TAL1 in alternate haematopoietic lineages | The EMBO Journal
On the other hand, E‐boxes are absent from an unexpectedly high proportion of TAL1 peaks (14% in Jurkat and 24% in erythroid cells) (Figure 6C). Consistent with this, the de novo motif search did not identify E‐boxes as the top overrepresented motif in erythroid or Jurkat cells (Figure 6A, left and middle panels). Instead, in erythroid cells, a Gata motif ranks first within overrepresented sites, and two variants of this motif are also among the top 7 overrepresented motifs (Figure 6A, middle panel). Furthermore, virtually all TAL1 peaks (96%) contain a Gata motif while only 76% contain an E‐box within a 100‐bp radius of the peak summit (Figure 6C). In erythroid cells, Gata motifs are also on average closer to TAL1 peak summits than E‐boxes, with 80% of TAL1 peaks containing a Gata site within 35 bp of the peak summit versus only 50% containing an E‐box within this distance (Figure 6C). This is consistent with previous studies showing cooccupation of TAL1 and GATA1 at many genomic ...
http://emboj.embopress.org/content/30/3/494
Cell cycle switch to endocycle: the nucleolus lends a hand. - Physiology, Anatomy and Genetics
The bHLH transcription factor Hand1 is essential for placentation and cardiac morphogenesis but how its developmental activity is regulated is largely unknown. We recently showed that Hand1 is sequestered in the nucleoli of rodent trophoblast stem (TS) cells by the I-mfa domain-containing protein HICp40 and that this is associated with their proliferation and continuing self-renewal. However when these cells commit to differentiate into trophoblast giant (TG) cells, Hand1 is phosphorylated by the polo-like kinase Plk4 (Sak) and released into the nucleus to activate downstream target genes. This event underlies the release of Hand1 from the nucleolus and represents the molecular switch that promotes mitotic cell cycle exit and the onset of endoreduplication. In this brief discussion we examine the wider implications of these findings and address some of the unanswered questions that remain.
https://www.dpag.ox.ac.uk/publications/251937
Serotonin-Expressing Cells in the Corpus of the Stomach Originate from by Brian T. JohnstonSerotonin-Expressing Cells in the Corpus of the Stomach Originate from by Brian T. Johnston
Neurogenin 3 and its downstream target NeuroD are basic helix-loop-helix transcription factors which promote endocrine differentiation in the gastrointestinal tract. However, mice lacking Ngn3 still produce several hormones in the stomach. Lineage tracing mouse models demonstrated that a majority of hormone cells in the corpus region of the stomach did not express Ngn3 or NeuroD during differentiation. Serotonin and histamine cells were entirely NeuroD-independently derived, and serotonin cells were additionally entirely Ngn3-independently derived. In this study, we isolated serotonin and histamine cells from the gastric corpus of transgenic mice expressing the fluorescent marker CFP. Serotonin cells expressed multiple mast cell markers by RT-PCR, and were found to be nearly absent in a mast cell-deficient mouse model. Labeled bone marrow transplant mice showed all serotonin cells derived from bone marrow. Histamine-expressing ECL cells, while lacking NeuroD, did not appear to express granulocyte or
http://escholarship.umassmed.edu/gsbs_diss/639/
Most recent papers with the keyword ngn2 | Read by QxMDMost recent papers with the keyword ngn2 | Read by QxMD
The zinc finger E-box-binding transcription factor Zeb1 plays a pivotal role in the epithelial-mesenchymal transition. Numerous studies have focused on the molecular mechanisms by which Zeb1 contributes to this process. However, the functions of Zeb1 beyond the epithelial-mesenchymal transition remain largely elusive. Using a transdifferentiation system to convert mouse embryonic fibroblasts (MEFs) into functional neurons via the neuronal transcription factors achaete-scute family bHLH (basic helix-loop-helix) transcription factor1 (Ascl1), POU class 3 homeobox 2 (POU3F2/Brn2), and neurogenin 2 (Neurog2, Ngn2) (ABN), we found that Zeb1 was up-regulated during the early stages of transdifferentiation ...
https://www.readbyqxmd.com/keyword/67856
Human eHAND, but not dHAND, is down-regulated in cardiomyopathies<...
TY - JOUR. T1 - Human eHAND, but not dHAND, is down-regulated in cardiomyopathies. AU - Natarajan, Aruna. AU - Yamagishi, Hiroyuki. AU - Ahmad, Ferhaan. AU - Li, Duanxiang. AU - Roberts, Robert. AU - Matsuoka, Rumiko. AU - Hill, Sandra. AU - Srivastava, Deepak. PY - 2001. Y1 - 2001. N2 - The progression of cardiomyopathy to congestive heart failure is often associated with the expression of fetal cardiac-specific genes. In mice, the basic helix-loop-helix transcription factors, dHAND and eHAND, are expressed in a cardiac chamber-specific fashion and are essential for fetal cardiac development, but are down-regulated in the adult. Their expression in specific chambers of healthy and diseased human hearts has not been studied previously. Human dHAND and eHAND were mapped to human chromosomes 4q33 and 5q33, respectively, by fluorescent in situ hybridization, RNA from the four chambers of healthy human adult hearts, and from hearts of patients with several forms of cardiomyopathy, was obtained and ...
https://keio.pure.elsevier.com/en/publications/human-ehand-but-not-dhand-is-down-regulated-in-cardiomyopathies
RePub, Erasmus University Repository: ETO2 coordinates cellular proliferation and differentiation during erythropoiesisRePub, Erasmus University Repository: ETO2 coordinates cellular proliferation and differentiation during erythropoiesis
The passage from proliferation to terminal differentiation is critical for normal development and is often perturbed in malignancies. To define the molecular mechanisms that govern this process during erythropoiesis, we have used tagging/proteomics approaches and characterized protein complexes nucleated by TAL-1/SCL, a basic helix-loop-helix transcription factor that specifies the erythrocytic lineage. In addition to known TAL-1 partners, GATA-1, E2A, HEB, LMO2 and Ldbl, we identify the ETO2 repressor as a novel component recruited to TAL-1 complexes through interaction with E2A/HEB. Ectopic expression and siRNA knockdown experiments in hematopoietic progenitor cells show that ETO2 actively represses erythroid TAL-1 target genes and governs the expansion of erythroid progenitors. At the onset of erythroid differentiation, a change in the stoichiometry of ETO2 within the TAL-1 complex activates the expression of known erythroid-specific TAL-1 target genes and of Gfi-1b and p21 Cip, encoding two ...
https://repub.eur.nl/pub/65783
Gene Expression Literature DetailGene Expression Literature Detail
J:89474 Morikawa Y, Cserjesi P, Extra-embryonic vasculature development is regulated by the transcription factor HAND1. Development. 2004 May;131(9):2195-204 ...
http://www.informatics.jax.org/gxdlit/key/37408
Transcription Factor 4 (TCF4) Antibody | Abbexa LtdTranscription Factor 4 (TCF4) Antibody | Abbexa Ltd
TCF4 Antibody is a Rabbit Polyclonal antibody against TCF4. This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes an Ephrussi-box (E-box) binding site (CANNTG) - a motif first identifie
https://www.abbexa.com/tcf4-antibody-3
Plus itPlus it
5291 Evasion from oncogene-induced senescence and apoptosis has recently emerged as being crucial for promoting tumorigenesis in vivo. The basic helix-loop-helix transcription factors Twist1 and Twist2 have been found to abrogate oncogene-induced apoptosis and Twist1 overexpression has been reported in a large variety of human solid cancers including carcinomas, sarcomas, melanomas and neuroblastomas. We show that both Twist proteins also override Ras- and ErbB2-induced senescence in murine and human cells, by simultaneously shutting-down p53- and RB-dependent pathways. In addition, like Twist1, Twist2 has an altered expression in a set of primary tumours and tumour cell lines, indicating that both genes might similarly contribute to tumour progression. Our results suggest the existence of a novel class of proteins whose oncogenic potential specifically derives from their ability to antagonize gatekeepers and which we propose to name gate-jumpers. ...
http://cancerres.aacrjournals.org/content/67/9_Supplement/5291
Expression pattern of the stem cell leukaemia gene in the CNS of the embryonic and adult mouse. - Semantic ScholarExpression pattern of the stem cell leukaemia gene in the CNS of the embryonic and adult mouse. - Semantic Scholar
The basic helix-loop-helix (bHLH) transcription factor stem cell leukaemia (SCL) is a master regulator of haematopoiesis, where SCL is pivotal in cell fate determination and differentiation. SCL has also been detected in CNS, where other members of the bHLH-family have been shown to be indispensable for neuronal development; however, no detailed expression pattern of SCL has so far been described. We have generated a map of SCL expression in the embryonic and adult mouse brain based on histochemical analysis of LacZ reporter gene expression in sequential sections of brain tissue derived from SCL-LacZ knockin mice. The expression of LacZ was confirmed to reflect SCL expression by in situ hybridisation. LacZ expression was found in a range of different diencephalic, mesencephalic and metencephalic brain nuclei in adult CNS. Co-localisation of LacZ with the neuronal marker NeuN indicated expression in post-mitotic neurons in adulthood. LacZ expression by neurons was confirmed in tissue culture analysis.
https://www.semanticscholar.org/paper/Expression-pattern-of-the-stem-cell-leukaemia-gene-Eekelen-Bradley/f0e2f71613fab1bc73494e4ca3b9a80f86f42db9
HEY1 hes related family bHLH transcription factor with YRPW motif 1 [Homo sapiens (human)] - Gene - NCBIHEY1 hes related family bHLH transcription factor with YRPW motif 1 [Homo sapiens (human)] - Gene - NCBI
This gene encodes a nuclear protein belonging to the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcriptional repressors. Expression of this gene is induced by the Notch and c-Jun signal transduction pathways. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008 ...
https://www.ncbi.nlm.nih.gov/gene/23462
HEY1 elisa kit | Dog hairy/enhancer-of-split related with YRPW motif 1 ELISA Kit-NP 001002953.1HEY1 elisa kit | Dog hairy/enhancer-of-split related with YRPW motif 1 ELISA Kit-NP 001002953.1
Buy HEY1 elisa kit, Dog hairy/enhancer-of-split related with YRPW motif 1 ELISA Kit-NP_001002953.1 (MBS9329067) product datasheet at MyBioSource, ELISA Kits
https://www.mybiosource.com/prods/ELISA-Kit/Dog/hairy-enhancer-of-split-related-with-YRPW-motif-1/HEY1/datasheet.php?products_id=9329067
Gene Expression Literature DetailGene Expression Literature Detail
J:165754 Watanabe T, Koibuchi N, Chin MT, Transcription factor CHF1/Hey2 regulates coronary vascular maturation. Mech Dev. 2010 Sep-Dec;127(9-12):418-27 ...
http://www.informatics.jax.org/gxdlit/key/114737
HIF-2 alpha/EPAS1 Antibody (ep190b) [HRP] (NB100-132H): Novus BiologicalsHIF-2 alpha/EPAS1 Antibody (ep190b) [HRP] (NB100-132H): Novus Biologicals
Mouse Monoclonal Anti-HIF-2 alpha/EPAS1 Antibody (ep190b) [HRP]. Validated: WB, ELISA, IHC, IHC-P. Tested Reactivity: Human, Mouse, Rat, and more. 100% Guaranteed.
https://www.novusbio.com/products/hif-2-alpha-epas1-antibody-ep190b_nb100-132h
anti-ATOH8 antibody | GeneTexanti-ATOH8 antibody | GeneTex
ATOH8 antibody (atonal homolog 8 (Drosophila)) for ELISA, IHC-P, WB. Anti-ATOH8 pAb (GTX85296) is tested in Human, Mouse, Rat samples. 100% Ab-Assurance.
http://www.genetex.com/ATOH8-antibody-GTX85296.html
ASCL2 (achaete-scute family bHLH transcription factor 2) - KOMP (Knockout Mouse Project)
The KOMP Repository Collection is located at the MMRRC at the University of California, Davis and Childrens Hospital Oakland Research Institute. Question? Comments? For Mice, Cells, and germplasm please contact us at [email protected], US 1-888-KOMP-MICE or International +1-530-752-KOMP, or for vectors [email protected] or +1-510-450-7917 ...
https://www.komp.org/geneinfo.php?MGI_Number=96920
Art of Problem SolvingArt of Problem Solving
Just as in Solution ,math,2,/math, and ,math,3,,/math, we rewrite ,math,\dfrac{1}{20^{20}},/math, as ,math,\dfrac{5^{20}}{10^{40}}.,/math, We can then look at the number of digits in powers of ,math,5,/math,. ,math,5^1=5,/math,, ,math,5^2=25,/math,, %5^3=125,math,, ,/math,5^4=625,math,, ,/math,5^5=3125,math,, ,/math,5^6=15625,math,, %5^7=78125,/math, and so on. We notice after a few iterations that every power of five with an exponent of ,math,1 (\mod 3),/math,, the number of digits doesnt increase. This means ,math,5^20,/math, should have ,math,20,/math, digits minus ,math,6,/math, since there are ,math,6,/math, numbers which are ,math,1 (\mod 3),/math, from ,math,0,/math, to ,math,20,/math,, or ,math,14,/math, digits total. This means our expression can be written as ,math,\dfrac{k\cdot10^{14}}{10^{40}},/math,, where ,math,k,/math, is in the range ,math,[1,10),/math,. Canceling gives ,math,\dfrac{k}{10^{26}},/math,, or 26 zeroes before the ,math,k,/math, since the number ,math,k,/math, should ...
https://artofproblemsolving.com/wiki/index.php?title=2020_AMC_10B_Problems/Problem_12&diff=next&oldid=117651
Art of Problem SolvingArt of Problem Solving
Problem == A three-dimensional rectangular box with dimensions ,math>X,/math>, ,math>Y,/math>, and ,math>Z,/math> has faces whose surface areas are ,math>24,/math>, ,math>24,/math>, ,math>48,/math>, ,math>48,/math>, ,math>72,/math>, and ,math>72,/math> square units. What is ,math>X,/math> + ,math>Y,/math> + ,math>Z,/math>? ,math> \textbf{(A) }18 \qquad \textbf{(B) }22 \qquad \textbf{(C) }24 \qquad \textbf{(D) }30 \qquad \textbf{(E) }36 \qquad ,/math> ==Solution 1== Let ,math>X,/math> be the length of the shortest dimension and ,math>Z,/math> be the length of the longest dimension. Thus, ,math>XY = 24,/math>, ,math>YZ = 72,/math>, and ,math>XZ = 48,/math>. Divide the first two equations to get ,math>\frac{Z}{X} = 3,/math>. Then, multiply by the last equation to get ,math>Z^2 = 144,/math>, giving ,math>Z = 12,/math>. Following, ,math>X = 4,/math> and ,math>Y = 6,/math>. The final answer is ,math>4 + 6 + 12 = 22,/math>. ,math>\boxed{B},/math> ==Solution 2== If you find the GCD of ,math>24,/math>, ...
https://artofproblemsolving.com/wiki/index.php?title=2018_AMC_10B_Problems/Problem_4&action=edit&oldid=101311
Neuronal PAS domain-containing protein 3Neuronal PAS domain-containing protein 3
This gene encodes a member of the basic helix-loop-helix and PAS domain-containing family of transcription factors. The encoded protein is localized to the nucleus and may regulate genes involved in neurogenesis. Chromosomal abnormalities that affect the coding potential of this gene are associated with schizophrenia and mental retardation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009 ...
https://pharos.nih.gov/idg/targets/Q8IXF0
Investigating the role for c-myc and bHLH transcription factors in driving phenotypic versatility of cancer stem cells in...
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https://www.nds.ox.ac.uk/publications/817521
Npas2 - Neuronal PAS domain-containing protein 2 - Mus musculus (Mouse) - Npas2 gene & proteinNpas2 - Neuronal PAS domain-containing protein 2 - Mus musculus (Mouse) - Npas2 gene & protein
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
https://www.uniprot.org/uniprot/G3X9B7
Atoh8 gene cDNA ORF clone, Mus musculus(house mouse) - GenScriptAtoh8 gene cDNA ORF clone, Mus musculus(house mouse) - GenScript
Next-day shipping cDNA ORF clones derived from Atoh8 atonal bHLH transcription factor 8 available at GenScript, starting from $99.00.
https://www.genscript.com/gene/mus-musculus/71093/atoh8.html
Nanomaterials | Free Full-Text | Neurogenic Differentiation of Human Dental Pulp Stem Cells on Graphene-Polycaprolactone Hybrid...Nanomaterials | Free Full-Text | Neurogenic Differentiation of Human Dental Pulp Stem Cells on Graphene-Polycaprolactone Hybrid...
Stem cells derived from dental tissues—dental stem cells—are favored due to their easy acquisition. Among them, dental pulp stem cells (DPSCs) extracted from the dental pulp have many advantages, such as high proliferation and a highly purified population. Although their ability for neurogenic differentiation has been highlighted and neurogenic differentiation using electrospun nanofibers (NFs) has been performed, graphene-incorporated NFs have never been applied for DPSC neurogenic differentiation. Here, reduced graphene oxide (RGO)-polycaprolactone (PCL) hybrid electrospun NFs were developed and applied for enhanced neurogenesis of DPSCs. First, RGO-PCL NFs were fabricated by electrospinning with incorporation of RGO and alignments, and their chemical and morphological characteristics were evaluated. Furthermore, in vitro NF properties, such as influence on the cellular alignments and cell viability of DPSCs, were also analyzed. The influences of NFs on DPSCs neurogenesis were also
https://www.mdpi.com/2079-4991/8/7/554
Neuronal PAS domain protein 4 (Npas4) controls neuronal homeostasis in pentylenetetrazole-induced epilepsy through the...Neuronal PAS domain protein 4 (Npas4) controls neuronal homeostasis in pentylenetetrazole-induced epilepsy through the...
Dive into the research topics of Neuronal PAS domain protein 4 (Npas4) controls neuronal homeostasis in pentylenetetrazole-induced epilepsy through the induction of Homer1a. Together they form a unique fingerprint. ...
https://pure.fujita-hu.ac.jp/en/publications/neuronal-pas-domain-protein-4-npas4-controls-neuronal-homeostasis/fingerprints/
Myc Proto Oncogene Protein (Transcription Factor p64 or Class E Basic Helix Loop Helix Protein 39 or MYC) - Pipeline Review, H2...
[38 Pages Report] Check for Discount on Myc Proto Oncogene Protein (Transcription Factor p64 or Class E Basic Helix Loop Helix Protein 39 or MYC) - Pipeline Review, H2 2017 report by Global Markets Direct. Myc Proto Oncogene Protein (Transcription Factor p64 or Class E...
http://www.reportsnreports.com/reports/1222401-myc-proto-oncogene-protein-transcription-factor-p64-or-class-e-basic-helix-loop-helix-protein-39-or-myc-pipeline-review-h2-2017.html
Mitogen-activated protein kinase phosphorylates and negatively regulates basic helix-loop-helix-PAS transcription factor BMAL1 ...
Dive into the research topics of Mitogen-activated protein kinase phosphorylates and negatively regulates basic helix-loop-helix-PAS transcription factor BMAL1. Together they form a unique fingerprint. ...
https://waseda.pure.elsevier.com/en/publications/mitogen-activated-protein-kinase-phosphorylates-and-negatively-re/fingerprints/
Genome-Wide Identification and Analysis of the Chicken Basic Helix-Loop-Helix FactorsGenome-Wide Identification and Analysis of the Chicken Basic Helix-Loop-Helix Factors
Members of the basic helix-loop-helix (bHLH) family of transcription factors play important roles in a wide range of developmental processes. In this study, we conducted a genome-wide survey using the chicken (|i|Gallus gallus|/i|) genomic database, and identified 104 bHLH sequences belonging to 42 gene families in an effort to characterize the chicken bHLH transcription factor family. Phylogenetic analyses revealed that chicken has 50, 21, 15, 4, 8, and 3 bHLH members in groups A, B, C, D, E, and F, respectively, while three members belonging to none of these groups were classified as orphans. A comparison between chicken and human bHLH repertoires suggested that both organisms have a number of lineage-specific bHLH members in the proteomes. Chromosome distribution patterns and phylogenetic analyses strongly suggest that the bHLH members should have arisen through gene duplication at an early date. Gene Ontology (GO) enrichment statistics showed 51 top GO annotations of biological processes counted
https://www.hindawi.com/journals/ijg/2010/682095/
Class E basic helix-loop-helix protein 23Class E basic helix-loop-helix protein 23
This gene encodes a member of the basic helix-loop-helix transcription factor family. Members of this family contain two highly conserved and functionally distinct domains: the basic domain targets sequence-specific DNA binding, while the helix-loop-helix domain facilitates protein interaction. Studies of a related gene in mouse suggest that the encoded protein may function as a transcriptional repressor in the pancreas and brain, and that it is required for normal retinal function. [provided by RefSeq, May 2013 ...
https://pharos.nih.gov/idg/targets/Q8NDY6
Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3 -...Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3 -...
Regulatory proteins have been identified in embryonic development of the endocrine pancreas. It is unknown whether these factors can also play a role in the formation of pancreatic endocrine cells from postnatal nonendocrine cells. The present study demonstrates that adult human pancreatic duct cells can be converted into insulin-expressing cells after ectopic, adenovirus-mediated expression of the class B basic helix-loop-helix factor neurogenin 3 (ngn3), which is a critical factor in embryogenesis of the mouse endocrine pancreas. Infection with adenovirus ngn3 (Adngn3) induced gene and/or protein expression of NeuroD/beta2, Pax4, Nkx2.2, Pax6, and Nkx6.1, all known to be essential for beta-cell differentiation in mouse embryos. Expression of ngn3 in adult human duct cells induced Notch ligands Dll1 and Dll4 and neuroendocrine- and beta-cell-specific markers: it increased the percentage of synaptophysin- and insulin-positive cells 15-fold in ngn3-infected versus control cells. Infection with NeuroD
https://www.semanticscholar.org/paper/Recapitulation-of-embryonic-neuroendocrine-differe-Heremans-Casteele/7fd981ff6aea0abaadf1cd07526f887e8673bf00
Anti-Human Olig2 Antibody | Human Olig2 Antibody | Olig2 AntibodyAnti-Human Olig2 Antibody | Human Olig2 Antibody | Olig2 Antibody
Oligodendrocyte lineage transcription factor 2 (Olig2) is a basic helix-loop-helix transcription factor expressed in oligodendroglial tumors of the brain. It is also known as protein kinase C binding protein 2 (PRKCBP2), oligodendrocyte transcription factor 2, oligodendrocyte-specific bHLH transcription factor 2, BHLHB1, bHLHe19, OLIGO2, and RACK17. Olig2 protein plays an essential role in regulating the development of oligodendrocytes and motor neurons. Chromosomal translocations in the OLIG2 gene have been associated with T-cell acute lymphoblastic leukemia (T-ALL) and development of Down syndrome. Olig2 expression is useful in distinguishing diffuse gliomas from other types of brain tumors.. ...
http://www.clontech.com/US/Products/Cell_Biology_and_Epigenetics/Brain_and_CNS/Olig2?sitex=10020:22372:US&PEBCL1=P4CmWHV0thzIxE6tTerv7RuPRj&PEBCL1_pses=ZGBC1AA8D5850079271F0503F7D5A912515F3BDE33306B412122E14F9CB93AC3C2094F1BAD1F772235EC670A5182B1735422418945AD075460
Anti-Human Olig2 Antibody | Human Olig2 Antibody | Olig2 AntibodyAnti-Human Olig2 Antibody | Human Olig2 Antibody | Olig2 Antibody
Oligodendrocyte lineage transcription factor 2 (Olig2) is a basic helix-loop-helix transcription factor expressed in oligodendroglial tumors of the brain. It is also known as protein kinase C binding protein 2 (PRKCBP2), oligodendrocyte transcription factor 2, oligodendrocyte-specific bHLH transcription factor 2, BHLHB1, bHLHe19, OLIGO2, and RACK17. Olig2 protein plays an essential role in regulating the development of oligodendrocytes and motor neurons. Chromosomal translocations in the OLIG2 gene have been associated with T-cell acute lymphoblastic leukemia (T-ALL) and development of Down syndrome. Olig2 expression is useful in distinguishing diffuse gliomas from other types of brain tumors.. ...
http://www.clontech.com/US/Products/Cell_Biology_and_Epigenetics/Brain_and_CNS/Olig2?sitex=10020:22372:US&PEBCL1=J5Lfz00dL3weqz0kfA9n6Wyyn0&PEBCL1_pses=ZG5BA658274C4EFA0AD290E9CC3DC2837226FFA3F36CF9EB2B1176DA5AA5FD354C4B025CD37D84A7FA61CC3A4D70E5F73A7FC2EA05C4279E74
Small molecules enable neurogenin 2 to efficiently convert human fibroblasts into cholinergic neurons<...
TY - JOUR. T1 - Small molecules enable neurogenin 2 to efficiently convert human fibroblasts into cholinergic neurons. AU - Liu, Meng Lu. AU - Zang, Tong. AU - Zou, Yuhua. AU - Chang, Joshua C.. AU - Gibson, Jay R.. AU - Huber, Kimberly M.. AU - Zhang, Chun Li. N1 - Funding Information: We thank the members of the Zhang lab for discussions and reagents. We also thank Eric Olson, Jane Johnson and Derek Smith for critical reading of the manuscript. C.-L.Z. is a W. W. Caruth Jr. Scholar in Biomedical Research. This work was supported by the Whitehall Foundation Award (2009-12-05), the Welch Foundation Award (I-1724), The Ellison Medical Foundation Award (AG-NS-0753-11) and NIH Grants (1DP2OD006484 and R01NS070981; to C.-L.Z.). Copyright: Copyright 2014 Elsevier B.V., All rights reserved.. PY - 2013. Y1 - 2013. N2 - Cell fate can be reprogrammed by modifying intrinsic and extrinsic cues. Here we show that two small molecules (forskolin and dorsomorphin) enable the transcription factor Neurogenin 2 ...
https://utsouthwestern.pure.elsevier.com/en/publications/small-molecules-enable-neurogenin-2-to-efficiently-convert-human-
ORBi: Browsing ORBiORBi: Browsing ORBi
in Developmental Biology (2005), 285(1), 211-23. Pancreas development relies on a network of transcription factors belonging mainly to the Homeodomain and basic Helix-Loop-Helix families. We show in this study that, in zebrafish, sox4, a member of the ... [more ▼]. Pancreas development relies on a network of transcription factors belonging mainly to the Homeodomain and basic Helix-Loop-Helix families. We show in this study that, in zebrafish, sox4, a member of the SRY-like HMG-box (SOX) family, is required for proper endocrine cell differentiation. We found that two genes orthologous to mammalian Sox4 are present in zebrafish and that only one of them, sox4b, is strongly expressed in the pancreatic anlage. Transcripts of sox4b were detected in mid-trunk endoderm from the 5-somite stage, well before the onset of expression of the early pancreatic gene pdx-1. Furthermore, by fluorescent double in situ hybridization, we found that expression of sox4b is mostly restricted to precursors of the ...
http://orbi.ulg.ac.be/browse?type=author&value=Mavropoulos%2C+A
Differential regulation of granulopoiesis by the basic helix-loop-helix transcriptional inhibitors Id1 and Id2. - Radcliffe...Differential regulation of granulopoiesis by the basic helix-loop-helix transcriptional inhibitors Id1 and Id2. - Radcliffe...
Inhibitor of DNA binding (Id) proteins function as inhibitors of members of the basic helix-loop-helix family of transcription factors and have been demonstrated to play an important role in regulating lymphopoiesis. However, the role of these proteins in regulation of myelopoiesis is currently unclear. In this study, we have investigated the role of Id1 and Id2 in the regulation of granulopoiesis. Id1 expression was initially up-regulated during early granulopoiesis, which was then followed by a decrease in expression during final maturation. In contrast, Id2 expression was up-regulated in terminally differentiated granulocytes. In order to determine whether Id expression plays a critical role in regulating granulopoiesis, Id1 and Id2 were ectopically expressed in CD34(+) cells by retroviral transduction. Our experiments demonstrate that constitutive expression of Id1 inhibits eosinophil development, whereas in contrast neutrophil differentiation was modestly enhanced. Constitutive Id2 expression
https://www.rdm.ox.ac.uk/publications/573060
Oral Presentation - ASN Events
Breast cancer is a heterogenous disease. It is becoming increasingly apparent that in many breast cancers, a minority of neoplastic cells comprising the tumor are drivers of the malignant, metastatic seeding ability and inherent chemoresistance of a tumor. We term these cells Tumor Propagating Cells (TPCs), referring only to their functional activity and not to their cell of origin. The characterization of TPCs has been largely hindered by the lack of reliable methods for the isolation and purification of these cells including the current best practice of using cell surface markers. Our strategy to isolate TPCs is to develop molecular probes that report on the activity of pathways controlling the TPC phenotype. We have identified a transcription factor, Id1 (Inhibitor of Differentiation 1) which is expressed by a rare cell in ~ 50% of Hormone receptor negative (HR-) breast cancers. The Id family (Id1-4) are basic Helix Loop Helix (bHLH) proteins which hetero-dimerize with other bHLH ...
http://metastasis-2012.p.asnevents.com.au/days/2012-09-03/abstract/1252
Epigenetic Regulation of Nestin Expression During Neurogenic Differentiation of Adipose Tissue Stem Cells.Epigenetic Regulation of Nestin Expression During Neurogenic Differentiation of Adipose Tissue Stem Cells.
Adipose-tissue-derived stem cells (ASCs) have received considerable attention due to their easy access, expansion potential, and differentiation ca...
https://www.diagenode.com/en/publications/view/1179
2 signals -- from within and out of cell -- specify motor neuron differentiation2 signals -- from within and out of cell -- specify motor neuron differentiation
Two signals - an external one from retinoic acid and an internal one from the transcription factor Neurogenin2 - cooperate to activate chromatin (the basic material of chromosomes) and help determine that certain nerve progenitor cells become motor neurons, said researchers from Baylor College of Medicine in a report in the current issue of the journal Neuron.
https://medicalxpress.com/news/2009-06-cell-motor-neuron-differentiation.html
twist: A Myogenic Switch in Drosophila | Sciencetwist: A Myogenic Switch in Drosophila | Science
Somatic muscle is derived from a subset of embryonic mesoderm. In Drosophila, Twist (Twi), a basic helix-loop-helix transcription factor, is a candidate regulator of mesodermal differentiation and myogenesis. Altering amounts of Twist after gastrulation revealed that high levels of Twist are required for somatic myogenesis and block the formation of other mesodermal derivatives. Expression of twist in the ectoderm drives these cells into myogenesis. Thus, after an initial role in gastrulation, twist regulates mesodermal differentiation and propels a specific subset of mesodermal cells into somatic myogenesis. Vertebrate homologs of twist may also participate in the subdivision of mesoderm.. ...
https://science.sciencemag.org/content/272/5267/1481?ijkey=d01d84e904015b4e4acb0c3b117acef13af546c9&keytype2=tf_ipsecsha
Phospho-regulation of ATOH1 Is Required for Plasticity of Secretory Progenitors and Tissue Regeneration. - MRC Weatherall...
The intestinal epithelium is largely maintained by self-renewing stem cells but with apparently committed progenitors also contributing, particularly following tissue damage. However, the mechanism of, and requirement for, progenitor plasticity in mediating pathological response remain unknown. Here we show that phosphorylation of the transcription factor Atoh1 is required for both the contribution of secretory progenitors to the stem cell pool and for a robust regenerative response. As confirmed by lineage tracing, Atoh1+ cells (Atoh1(WT)CreERT2 mice) give rise to multilineage intestinal clones both in the steady state and after tissue damage. In a phosphomutant Atoh1(9S/T-A)CreERT2 line, preventing phosphorylation of ATOH1 protein acts to promote secretory differentiation and inhibit the contribution of progenitors to self-renewal. Following chemical colitis, Atoh1+ cells of Atoh1(9S/T-A)CreERT2 mice have reduced clonogenicity that affects overall regeneration. Progenitor plasticity maintains robust
https://www.imm.ox.ac.uk/publications/905696
Difference between revisions of Math 764 -- Algebraic Geometry II -- Homeworks - MathDifference between revisions of Math 764 -- Algebraic Geometry II -- Homeworks - Math
As in the previous problem, supposed ,math,{\mathcal{F}},/math, be a coherent sheaf on a locally noetherian scheme ,math,X,/math,. The fiber of ,math,{\mathcal{F}},/math, at a point ,math,x\in X,/math, is the ,math,k(x),/math,-vector space ,math,i^*{\mathcal{F}},/math, for the natural map ,math,i:{\mathop{Spec}}(k(x))\to X,/math, (where ,math,k(x),/math, is the residue field of ,math,x\in X,/math,). Denote by ,math,\phi(x),/math, the dimension ,math,\dim_{k(x)} i^*{\mathcal{F}},/math,.,p,(a) Show that the function ,math,\phi(x),/math, is upper semi-continuous: for every ,math,n,/math,, the set ,math,\{x\in X:\phi(x)\ge n\},/math, is closed.,/p,,p,(b) Suppose ,math,X,/math, is reduced. Show that ,math,{\mathcal{F}},/math, is locally free if and only if ,math,\phi(x),/math, is constant on each connected component of ,math,X,/math,. (Do you see why we impose the assumption that ,math,X,/math, is reduced here?),/p ...
http://www.math.wisc.edu/wiki/index.php?title=Math_764_--_Algebraic_Geometry_II_--_Homeworks&diff=prev&oldid=13449
BTZ044 | Targeting NRAS in Melanoma and Acute Myelogenous LeukemiaBTZ044 | Targeting NRAS in Melanoma and Acute Myelogenous Leukemia
Twist1 and Twist2 are highly conserved people of the Twist subfamily of bHLH proteins responsible for the transcriptional regulation of the developmental programs in mesenchymal cell lineages. regulatory elements made up of the consensus sequence 5′-NCANNTGN-3′ (termed E-box). E-boxes are found in the regulatory regions of many lineage specific genes which account for the numerous pathways regulated by these transcription factors (1-3). The bHLH transcription factors are classified into three major classes: the ubiquitous Class A bHLH factors that include E2-2 HEB and the two isoforms of the E2A gene E12/E47 (also known as E proteins); the tissue-restricted Class B bHLH factors; and the inhibitory HLH proteins constituted by the Id proteins which lack the basic region used Mouse monoclonal to KSHV ORF45 to contact DNA. The Twist proteins form a subfamily of the Class B bHLH factors. These include Paraxis (1) Scleraxis (4) Hand1 (5) Hand2 (6) Twist1 and BTZ044 Twist2. In this family of ...
http://scienceofgreathealth.com/tag/btz044/
TCF21 antibodies | AntibodypediaTCF21 antibodies | Antibodypedia
TCF21 encodes a transcription factor of the basic helix-loop-helix family. The TCF21 product is mesoderm specific, and expressed in embryonic epicardium, mesenchyme-derived tissues of lung, gut, gonad, and both mesenchymal and glomerular epithelial cells in the kidney. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] ...
https://www.antibodypedia.com/gene/19727/TCF21
ID2 (Inhibitor Of DNA Binding 2, Dominant Negative Helix-Loop-Helix Protein)ID2 (Inhibitor Of DNA Binding 2, Dominant Negative Helix-Loop-Helix Protein)
ID2 (Inhibitor Of DNA Binding 2, Dominant Negative Helix-Loop-Helix Protein), Authors: Menno C van Zelm. Published in: Atlas Genet Cytogenet Oncol Haematol.
http://atlasgeneticsoncology.org/Genes/ID2ID436ch2p25.html
Anti-NSCL1 (HEN1; Helix-loop-helix protein 1) Polyclonal Antibody, Unconjugated from CHEMICONAnti-NSCL1 (HEN1; Helix-loop-helix protein 1) Polyclonal Antibody, Unconjugated from CHEMICON
Anti-NSCL1 (HEN1; Helix-loop-helix protein 1) Polyclonal Antibody, Unconjugated from CHEMICON,Recognizes NSCL1. The molecular weight of the protein is 14,616 Daltons.,biological,biology supply,biology supplies,biology product
http://www.bio-medicine.org/biology-products/Anti-NSCL1--28HEN1-3B-Helix-loop-helix-protein-1-29-Polyclonal-Antibody--Unconjugated-from-CHEMICON-4104-1/
OriGene - Heyl (NM 013905) cDNA CloneOriGene - Heyl (NM 013905) cDNA Clone
Heyl - Heyl (untagged) - Mouse hairy/enhancer-of-split related with YRPW motif-like (Heyl), (10ug) available for purchase from OriGene - Your Gene Company.
http://www.origene.com/Mouse_cDNA/MC210027.aspx
Most recent papers with the keyword Therapie | Read by QxMDMost recent papers with the keyword Therapie | Read by QxMD
The inhibitor of DNA binding and cell differentiation (Id) proteins are dominant negative regulators of the helix-loop-helix transcription factor family and play a key role during development as well as in vascular disorders and cancer. In fact, impairing the Id-protein activity in cancer cells reduces cell growth and even chemoresistance. Recently, we have shown that a synthetic Id-protein ligand (1Y) consisting of a cyclic nonapeptide can reduce the viability of the two breast cancer cell lines MCF-7 and T47D and of the bladder cancer cells T24 to about 50% at concentrations ≥100μM ...
https://www.readbyqxmd.com/keyword/43850
The BHLHE40 gene and its putative association with human ageingThe BHLHE40 gene and its putative association with human ageing
This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with ARNTL or compete for E-box binding sites in the promoter of PER1 and repress CLOCK/ARNTLs transactivation of PER1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation. [provided by RefSeq, Feb 2014 ...
http://genomics.senescence.info/cells/gene.php?gene_name=BHLHE40
jira] [Updated] (MATH-746) Things to do before releasing 3.0jira] [Updated] (MATH-746) Things to do before releasing 3.0
https://issues.apache.org/jira/browse/MATH-746?page=com.atlassian.jira.plugin.system.issuetabpanels:all-tabpanel ] Gilles updated MATH-746: ------------------------ Description: This issue is meant to contain a list of tasks to be completed before the release. * Remarks to be added to the *release notes*: ** Experimental code: {{BOBYQAOptimizer}} (cf. MATH-621) *** Many code paths untested *** Looking for volunteers to improve the code readability, robustness and performance *** Looking for volunteers to extend the test suite ** {{FastMath}} is not always faster than {{Math}} (issue MATH-740) ** List of new features * Create a release branch * Disable CheckStyle scanning of {{BOBYQAOptimizer}} (/) ({{r1244855}}) * Comment out print statements in {{BOBYQAOptimizerTest}} (/) ({{r1244975}}) * Remove unit test class {{BatteryNISTTest}} * Remove class {{PivotingQRDecomposition}} * Comment out print statement in {{SymmLQTest}} (/) ({{r1244992}}) (removed in {{r1244996}}) * Findbugs: ** ...
http://mail-archives.apache.org/mod_mbox/commons-issues/201202.mbox/%[email protected].org%3E
BHLHE40 antibody (OAAB00664) | 2 Homologous speciesBHLHE40 antibody (OAAB00664) | 2 Homologous species
Anti-BHLHE40 antibody | Application: WB, ELISA | Predicted species reactivity: Human, Mouse | Product type: Polyclonal Antibody | Alias: BHLHE40,Class E basic helix-loop-helix protein 40,BHLHB2; DEC1; SHARP2; STRA13
https://www.avivasysbio.com/bhlhe40-antibody-n-terminal-region-oaab00664.html
ID2 - ويكيبيدياID2 - ويكيبيديا
Wong J, Funes-Duran M, Ahlberg J, Round J, OConnell R, Miller R, Chen E, Richmond PA, Vierra CA (2001). Characterization of a basic helix-loop-helix protein, ABF-1: nuclear localization, transcriptional properties, and interaction with Id-2. DNA Cell Biol. 20 (8): 465-71. doi:10.1089/104454901316976091. PMID 11560778 ...
https://ar.wikipedia.org/wiki/ID2
Anti MAX (pSer11) Antibody | Bio-Rad Antibodies (formerly AbD Serotec)Anti MAX (pSer11) Antibody | Bio-Rad Antibodies (formerly AbD Serotec)
Rabbit anti MAX (pSer11) antibody recognizes MAX, also known as protein max, class D basic helix-loop-helix protein 4, bHLHd4 or Myc-assoc
https://www.bio-rad-antibodies.com/human-max-pser11-antibody-ahp2647.html
Visualising β-cells in the pancreas | Disease Models & MechanismsVisualising β-cells in the pancreas | Disease Models & Mechanisms
In both type 1 and type 2 diabetes, the β-cells of the islets of Langerhans in the pancreas are either destroyed or defective, resulting in insufficient insulin production. To study β-cells in development and disease, Shimajiri et al. generated a mouse in which expression of green fluorescent protein and secreted alkaline phosphatase is driven using the regulatory regions of the β-cell-specific neurogenin-3 gene. Pancreatic organ cultures derived from these mice allow developing β-cells to be visualised. In addition, this model system enables tracking the fate of developing β-cells in response to various stimuli.. Page 268. ...
http://dmm.biologists.org/content/4/2/135.5
Factoring Review Worksheet - Lariverannex
Great intro factoring algebra ii quadratics simplifying rational expressions solving quadratic equations. Factoring worksheet answers factor math formulas studying. Factoring quadratics color matching worksheet teaching algebra. Factoring quadratics greater 1 teacher created resources. Factoring real numbers adding subtracting polynomials algebra worksheets.
https://lariverannex.com/factoring-review-worksheet/
anti-HEY1 antibody, C-term | GeneTexanti-HEY1 antibody, C-term | GeneTex
HEY1 antibody, C-term (hes related family bHLH transcription factor with YRPW motif 1) for IHC-P, WB. Anti-HEY1 pAb (GTX42614) is tested in Human samples. 100% Ab-Assurance.
http://www.genetex.com/HEY1-antibody-C-term-GTX42614.html
LDPartEditor] 0.8.24 Beta Released (Rounding per X,Y,Z / bugfix)LDPartEditor] 0.8.24 Beta Released (Rounding per X,Y,Z / bugfix)
Looks like this issue is not completely cleared... After some time using LDPE, the Merge/split-,Set X,Y,Z window refuses to open on a multiple selection again. I guess that I do something that modifies LDPE state, and from then on, Merge/split-,Set X,Y,Z stops working. Close/reopen file does not cure the issue, the only way I found is to completely shut down LDPE. Unfortunately, though it happened 3 times, I was not able to determine the trigger for this behaviour ...
https://forums.ldraw.org/thread-21746-post-23044.html
Algebraic Geometry Seminar Spring 2017 - UW-Math WikiAlgebraic Geometry Seminar Spring 2017 - UW-Math Wiki
The Spin-Brauer diagram algebra Schur-Weyl duality is an important result in representation theory which states that the actions of [math]\mathfrak{S}_n[/math] and [math]\mathbf{GL}(N)[/math] on [math]\mathbf{V}^{\otimes n}[/math] generate each others commutants. Here [math]\mathfrak{S}_n[/math] is the symmetric group and [math]\mathbf{V}[/math] is the standard complex representation. In this talk, we investigate the Spin-Brauer diagram algebra, which arises from studying an analogous form of Schur-Weyl duality for the action of the spinor group on [math]\mathbf{V}^{\otimes n} \otimes \Delta[/math]. Here [math]\mathbf{V}[/math] is again the standard [math]N[/math]-dimensional complex representation of [math]{\rm Pin}(N)[/math] and [math]\Delta[/math] is the spin representation. We will give a general construction of the Spin-Brauer diagram algebra, discuss its connection to [math]{\rm End}_{{\rm Pin}(N)}(V^{\otimes n} \otimes \Delta)[/math] and time permitting we will mention some interesting ...
https://hilbert.math.wisc.edu/wiki/index.php?title=Algebraic_Geometry_Seminar_Spring_2017&direction=prev&oldid=13584
900+ Homeschool Math ideas | homeschool math, math, fun math900+ Homeschool Math ideas | homeschool math, math, fun math
Jan 20, 2020 - Homeschool math curriculum, games, activities and ideas to help you make math fun! . See more ideas about homeschool math, math, fun math.
https://ro.pinterest.com/homeschoolon/homeschool-math/
Mutagenesis of the mouse Bhlhb4 gene. A: Gene targeting | Open-iMutagenesis of the mouse Bhlhb4 gene. A: Gene targeting | Open-i
Mutagenesis of the mouse Bhlhb4 gene. A: Gene targeting strategy showing partial restriction map of WT Bhlhb4 allele, the targeting vector, the targeted ES cell
https://openi.nlm.nih.gov/detailedresult.php?img=PMC2665264_cne0507-1795-fu4&req=4
Basic helix-loop-helix leucine zipper transcription factorsBasic helix-loop-helix leucine zipper transcription factors
... are, as their name indicates, transcription factors containing both ... Basic+helix-loop-helix+leucine+zipper+transcription+factors at the US National Library of Medicine Medical Subject Headings ( ... Basic helix-loop-helix and leucine zipper motifs. Examples include Microphthalmia-associated transcription factor and Sterol ... Transcription factors, All stub articles, Genetics stubs). ...
https://en.wikipedia.org/wiki/Basic_helix-loop-helix_leucine_zipper_transcription_factors
NPAS1NPAS1
... is a basic helix-loop-helix transcription factor. NPAS3 Zhou YD, Barnard M, Tian H, Li X, Ring HZ, Francke U, Shelton J, ... "Characterization of a subset of the basic helix-loop-helix-PAS superfamily that interacts with components of the dioxin ... Transcription factors, PAS-domain-containing proteins, All stub articles, Human chromosome 19 gene stubs). ...
https://en.wikipedia.org/wiki/NPAS1
HLF (gene)HLF (gene)
"Entrez Gene: HLF hepatic leukemia factor". LeBrun DP (May 2003). "E2A basic helix-loop-helix transcription factors in human ... This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The ... Transcription factors, All stub articles, Human chromosome 17 gene stubs). ... "Enhanced binding of HLF/DBP heterodimers represents one mechanism of PAR protein transactivation of the factor VIII and factor ...
https://en.wikipedia.org/wiki/HLF_(gene)
NeurogeninsNeurogenins
Neurogenin 1 (Ngn1) is a Class-A basic-helix-loop-helix (bHLH) transcription factor that acts as a regulator for neuronal ... Li HJ, Ray SK, Singh NK, Johnston B, Leiter AB (Oct 2011). "Basic helix-loop-helix transcription factors and enteroendocrine ... The promotion of GFAP transcription induced glial differentiation. Neurogenin 2 (Ngn2) is a bHLH transcription factor involved ... Another transcription factor that may be a downstream target of Ngn3 is Nkx2.2 because it is often coexpressed with it. Studies ...
https://en.wikipedia.org/wiki/Neurogenins
ANKS1BANKS1B
LeBrun DP (2004). "E2A basic helix-loop-helix transcription factors in human leukemia". Front. Biosci. 8 (1-3): s206-22. doi: ... "Regulation of amyloid precursor protein expression and secretion via activation of ERK1/2 by hepatocyte growth factor in HEK293 ...
https://en.wikipedia.org/wiki/ANKS1B
MYF6MYF6
Myogenic factors are basic helix-loop-helix (bHLH) transcription factors. MYF6 is a gene that encodes a protein involved in the ... "A novel type of calmodulin interaction in the inhibition of basic helix-loop-helix transcription factors". Biochemistry. 39 (15 ... "Differential interactions of Id proteins with basic-helix-loop-helix transcription factors". The Journal of Biological ... The portion of the protein integral to myogenesis regulation requires the basic helix-loop-helix (bHLH) domain that is ...
https://en.wikipedia.org/wiki/MYF6
MYF5MYF5
... belongs to a family of proteins known as myogenic regulatory factors (MRFs). These basic helix loop helix transcription ... "Differential interactions of Id proteins with basic-helix-loop-helix transcription factors". The Journal of Biological ... MRF family members include Myf5, MyoD (Myf3), myogenin, and MRF4 (Myf6). This transcription factor is the earliest of all MRFs ... As for its clinical significance, the aberration of this transcription factor provides part of the mechanism for how hypoxia ( ...
https://en.wikipedia.org/wiki/MYF5
Cyclin D1Cyclin D1
Ratineau C, Petry MW, Mutoh H, Leiter AB (March 2002). "Cyclin D1 represses the basic helix-loop-helix transcription factor, ... Zhang T, Liu WD, Saunee NA, Breslin MB, Lan MS (February 2009). "Zinc finger transcription factor INSM1 interrupts cyclin D1 ... Cyclin D1-CDK4 also associates with several transcription factors and transcriptional co-regulators. Independent of CDK, cyclin ... allowing E2F transcription factors to transcribe genes required for entry into the S phase. Inactive pRb allows cell cycle ...
https://en.wikipedia.org/wiki/Cyclin_D1
LOC642658LOC642658
Basic helix-loop-helix transcription factor scleraxis is a protein that in humans is encoded by the SCXB gene. GRCh38: Ensembl ... "Entrez Gene: LOC642658 similar to Basic helix-loop-helix transcription factor scleraxis". v t e (Articles with short ...
https://en.wikipedia.org/wiki/LOC642658
MyoDMyoD
... basic helix loop helix) transcription factors act sequentially in myogenic differentiation. Vertebrate MRF family members ... "Differential interactions of Id proteins with basic-helix-loop-helix transcription factors". J. Biol. Chem. 272 (32): 19785-93 ... now referred to as basic helix loop helix) for dimerization and a basic site upstream of this bHLH region facilitated DNA ... Finkel T, Duc J, Fearon ER, Dang CV, Tomaselli GF (January 1993). "Detection and modulation in vivo of helix-loop-helix protein ...
https://en.wikipedia.org/wiki/MyoD
TAL1TAL1
The protein encoded by TAL1 is a basic helix-loop-helix transcription factor. TAL1 has been shown to interact with: CBFA2T3, ... Green AR, Begley CG (1993). "SCL and related hemopoietic helix-loop-helix transcription factors". Int. J. Cell Cloning. 10 (5 ... "The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells". Proc. Natl. ... "The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells". Proc. Natl. ...
https://en.wikipedia.org/wiki/TAL1
SIM2SIM2
Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors". The Journal of Biological Chemistry. ... Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors". The Journal of Biological Chemistry. ... Ooe N, Saito K, Mikami N, Nakatuka I, Kaneko H (Jan 2004). "Identification of a novel basic helix-loop-helix-PAS factor, NXF, ... Ooe N, Saito K, Mikami N, Nakatuka I, Kaneko H (Jan 2004). "Identification of a novel basic helix-loop-helix-PAS factor, NXF, ...
https://en.wikipedia.org/wiki/SIM2
Pho4Pho4
... is a protein with a basic helix-loop-helix (bHLH) transcription factor. It is found in S. cerevisiae and other yeasts. It ... Berben G, Legrain M, Gilliquet V, Hilger F (1990). "The yeast regulatory gene PHO4 encodes a helix-loop-helix motif". Yeast. 6 ... Additionally, another transcription factor known as Pho2, binds to Pho4 and assists in Pho4's ability to bind tightly to its ... The DNA-binding domain of PHO4 consists of two helices, designated H1 and H2, separated by a long loop that contains a novel α- ...
https://en.wikipedia.org/wiki/Pho4
Aryl hydrocarbon receptor nuclear translocatorAryl hydrocarbon receptor nuclear translocator
Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors". J. Biol. Chem. 277 (12): 10236-43. doi: ... Ooe N, Saito K, Mikami N, Nakatuka I, Kaneko H (January 2004). "Identification of a novel basic helix-loop-helix-PAS factor, ... Wang GL, Jiang BH, Rue EA, Semenza GL (1995). "Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated ... "Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin ...
https://en.wikipedia.org/wiki/Aryl_hydrocarbon_receptor_nuclear_translocator
HES1HES1
This protein belongs to the basic helix-loop-helix (bHLH) family of transcription factors. It is a transcriptional repressor of ... Jögi A, Persson P, Grynfeld A, Påhlman S, Axelson H (2002). "Modulation of basic helix-loop-helix transcription complex ... a basic helix-loop-helix repressor of neuronal differentiation". Genes Dev. 11 (23): 3168-81. doi:10.1101/gad.11.23.3168. PMC ... and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-1. Negative autoregulation through the ...
https://en.wikipedia.org/wiki/HES1
DTX1DTX1
... it may play a role in basic helix-loop-helix transcription factor activity. DTX1 has been shown to interact with EP300. GRCh38 ...
https://en.wikipedia.org/wiki/DTX1
ATOH1ATOH1
2007). "Basic helix-loop-helix transcription factor profiling of lung tumors shows aberrant expression of the proneural gene ... This protein belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent ... "The intestine-specific homeobox gene Cdx2 induces expression of the basic helix-loop-helix transcription factor Math1". ... Leow CC, Polakis P, Gao WQ (November 2005). "A role for Hath1, a bHLH transcription factor, in colon adenocarcinoma". Annals of ...
https://en.wikipedia.org/wiki/ATOH1
Sterol regulatory element-binding proteinSterol regulatory element-binding protein
SREBPs belong to the basic-helix-loop-helix leucine zipper class of transcription factors. Unactivated SREBPs are attached to ... Gasic GP (Apr 1994). "Basic-helix-loop-helix transcription factor and sterol sensor in a single membrane-bound molecule". Cell ... a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene". Cell ... SREBPs have a structure similar to E-box-binding helix-loop-helix (HLH) proteins. However, in contrast to E-box-binding HLH ...
https://en.wikipedia.org/wiki/Sterol_regulatory_element-binding_protein
TAL2TAL2
... is a member of the basic helix-loop-helix family of transcription factors. Tumor-specific alterations of the TAL2 gene ... Baer R (December 1993). "TAL1, TAL2 and LYL1: a family of basic helix-loop-helix proteins implicated in T cell acute leukaemia ... 1992). "TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia". Proc. Natl. Acad ... a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia". Proc. Natl. Acad. Sci. U.S.A. ...
https://en.wikipedia.org/wiki/TAL2
Ethylin Wang JabsEthylin Wang Jabs
... a basic helix-loop-helix transcription factor, in Saethre-Chotzen syndrome". Nature Genetics. 15 (1): 36-41. doi:10.1038/ng0197 ... She discovered that similar mutations in the same gene, fibroblast growth factor receptor 2 or FGFR2, cause both Jackson-Weiss ... "Jackson-Weiss and Crouzon syndromes are allelic with mutations in fibroblast growth factor receptor 2". Nature Genetics. 8 (3 ...
https://en.wikipedia.org/wiki/Ethylin_Wang_Jabs
MYCLMYCL
... 1 is a bHLH (basic helix-loop-helix) transcription factor implicated in lung cancer. MYCL1 has been shown to interact with ... Blackwood EM, Eisenman RN (Mar 1991). "Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding ... Lüscher B (2001). "Function and regulation of the transcription factors of the Myc/Max/Mad network". Gene. 277 (1-2): 1-14. doi ... Transcription factors, All stub articles, Human chromosome 1 gene stubs). ...
https://en.wikipedia.org/wiki/MYCL
TCF21 (gene)TCF21 (gene)
TCF21 encodes a transcription factor of the basic helix-loop-helix (bHLH) family, which manages cell-fate specification, ... Lu J, Chang P, Richardson JA, Gan L, Weiler H, Olson EN (August 2000). "The basic helix-loop-helix transcription factor ... Funato N, Ohyama K, Kuroda T, Nakamura M (February 2003). "Basic helix-loop-helix transcription factor epicardin/capsulin/Pod-1 ... basic helix-loop-helix) family of transcription factors. This protein is predicted to span 179 amino acid residues and contains ...
https://en.wikipedia.org/wiki/TCF21_(gene)
NEUROD2NEUROD2
"Interaction of PKN with a neuron-specific basic helix-loop-helix transcription factor, NDRF/NeuroD2". Brain Research. Molecular ... "Interaction of PKN with a neuron-specific basic helix-loop-helix transcription factor, NDRF/NeuroD2". Brain Research. Molecular ... This gene encodes a member of the neuroD family of neurogenic basic helix-loop-helix (bHLH) proteins. Expression of this gene ... a NeuroD family basic helix-loop-helix protein". Brain Research. Molecular Brain Research. 60 (1): 107-14. doi:10.1016/S0169- ...
https://en.wikipedia.org/wiki/NEUROD2
Mef2Mef2
"Combinatorial control of muscle development by basic helix-loop-helix and MADS-box transcription factors". Proc Natl Acad Sci ... Mef2c upregulates the expression of the homeodomain transcription factors DLX5 and DLX6, two transcription factors that are ... MEF2, Myocyte Enhancer Factor 2, is a transcription factor with four specific numbers such as MEF2A, B, C, and D. Each MEF2 ... "Myocyte Enhancer Factor 2 Transcription Factors in Heart Development and Disease." Heart Development and Regeneration, 2010, pp ...
https://en.wikipedia.org/wiki/Mef2
Class A basic helix-loop-helix protein 15Class A basic helix-loop-helix protein 15
Lemercier C, To RQ, Carrasco RA, Konieczny SF (1998). "The basic helix-loop-helix transcription factor Mist1 functions as a ... Class A basic helix-loop-helix protein 15 (bHLHa15) also known as class B basic helix-loop-helix protein 8 (bHLHb8) or muscle, ... 2006). "Identification of a basic helix-loop-helix transcription factor expressed in mammary gland alveolar cells and required ... 1997). "Mist1: a novel basic helix-loop-helix transcription factor exhibits a developmentally regulated expression pattern". ...
https://en.wikipedia.org/wiki/Class_A_basic_helix-loop-helix_protein_15
OLIG1OLIG1
"Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors". Neuron. 25 ... McLellan AS, Langlands K, Kealey T (Dec 2002). "Exhaustive identification of human class II basic helix-loop-helix proteins by ... McLellan AS, Langlands K, Kealey T (Dec 2002). "Exhaustive identification of human class II basic helix-loop-helix proteins by ... "Dynamic expression of basic helix-loop-helix Olig family members: implication of Olig2 in neuron and oligodendrocyte ...
https://en.wikipedia.org/wiki/OLIG1
Protein kinase N1Protein kinase N1
"Interaction of PKN with a neuron-specific basic helix-loop-helix transcription factor, NDRF/NeuroD2". Brain Res. Mol. Brain Res ... which is a potential transcription factor". Exp. Cell Res. 241 (2): 363-72. doi:10.1006/excr.1998.4060. PMID 9637778. Takahashi ...
https://en.wikipedia.org/wiki/Protein_kinase_N1
Myogenic determination factor 5Myogenic determination factor 5
"Combinatorial control of muscle development by basic helix-loop-helix and MADS-box transcription factors". Proc. Natl. Acad. ... A C-terminal Myf5 domain, a central basic helix-loop-helix (bHLH) domain and an N-terminal basic domain. The bHLH region ... Hamamori Y, Wu HY, Sartorelli V, Kedes L (November 1997). "The basic domain of myogenic basic helix-loop-helix (bHLH) proteins ... With 12 residues of the basic domain involved in DNA binding. The basic domain forms an extended alpha helix in the structure. ...
https://en.wikipedia.org/wiki/Myogenic_determination_factor_5
ASCL2ASCL2
This gene is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by ... is a maternally expressed imprinted gene that codes is a part of the basic helix-loop-helix (BHLH) transcription factor family ... "A novel type of calmodulin interaction in the inhibition of basic helix-loop-helix transcription factors". Biochemistry. 39 (15 ... possible role of placenta-specific basic helix-loop-helix transcription factor, human achaete-scute homologue-2". Journal of ...
https://en.wikipedia.org/wiki/ASCL2
ARNTLARNTL
... encodes a transcription factor with a basic helix-loop-helix (bHLH) and two PAS domains. The human ARNTL gene has a ... that encodes for a basic helix-loop-helix PAS domain transcription factor. It, too, has been shown to play a circadian role, ... "Mitogen-activated protein kinase phosphorylates and negatively regulates basic helix-loop-helix-PAS transcription factor BMAL1 ... Ooe N, Saito K, Mikami N, Nakatuka I, Kaneko H (January 2004). "Identification of a novel basic helix-loop-helix-PAS factor, ...
https://en.wikipedia.org/wiki/ARNTL
Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activationMitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation
Basic Helix-Loop-Helix Transcription Factors * DNA, Mitochondrial * HIF1A protein, human * Hypoxia-Inducible Factor 1, alpha ...
https://pubmed.ncbi.nlm.nih.gov/16054088/
The basic helix-loop-helix transcription factor capsulin controls spleen organogenesis<...
The basic helix-loop-helix transcription factor capsulin controls spleen organogenesis. Jianrong Lu, Priscilla Chang, James A. ... The basic helix-loop-helix transcription factor capsulin controls spleen organogenesis. Proceedings of the National Academy of ... The basic helix-loop-helix transcription factor capsulin controls spleen organogenesis. In: Proceedings of the National Academy ... Lu, J, Chang, P, Richardson, JA, Gan, L, Weiler, H & Olson, EN 2000, The basic helix-loop-helix transcription factor capsulin ...
https://augusta.pure.elsevier.com/en/publications/the-basic-helix-loop-helix-transcription-factor-capsulin-controls
TWIST1 gene: MedlinePlus GeneticsTWIST1 gene: MedlinePlus Genetics
Specifically, the TWIST1 protein is part of a large protein family called basic helix-loop-helix (bHLH) transcription factors. ... This protein is a transcription factor, which means that it attaches (binds) to specific regions of DNA and controls the ... The bHLH family of transcription factors helps regulate the development of many organs and tissues before birth. ... twist basic helix-loop-helix transcription factor 1. *Twist Homolog. *twist homolog 1 (acrocephalosyndactyly 3; Saethre-Chotzen ...
https://medlineplus.gov/genetics/gene/twist1/
EMT, MET, Plasticity, and Tumor Metastasis: Trends in Cell BiologyEMT, MET, Plasticity, and Tumor Metastasis: Trends in Cell Biology
Twist-related protein 1/2; basic helix-loop-helix transcription factors. Cells undergoing EMT demonstrate increased expression ... SRY-box transcription factor 4; a member of the SOX family of transcription factors important in regulating the expression of ... zinc-finger E-box-binding homeobox 1/2; Zeb1 and Zeb2 are paralogs belonging to the Zeb family of transcription factors. They ... the gene that encodes Snai2/Snail2, a zinc-finger transcription factor involved in the promotion of EMT. ...
https://www.cell.com/trends/cell-biology/fulltext/S0962-8924
Somatic HIF2A gain-of-function mutations in paraganglioma with polycythemiaSomatic HIF2A gain-of-function mutations in paraganglioma with polycythemia
However, mutations in genes encoding α subunits of hypoxia-inducible factors (HIF-α … ... Hypoxia-inducible factors are transcription factors controlling energy, iron metabolism, erythropoiesis, and development. When ... Basic Helix-Loop-Helix Transcription Factors / genetics* * Basic Helix-Loop-Helix Transcription Factors / metabolism ... Hypoxia-inducible factors are transcription factors controlling energy, iron metabolism, erythropoiesis, and development. When ...
https://pubmed.ncbi.nlm.nih.gov/22931260/?dopt=Abstract
TCF23 transcription factor 23 [Homo sapiens (human)] - Gene - NCBITCF23 transcription factor 23 [Homo sapiens (human)] - Gene - NCBI
transcription factor 23. Names. class A basic helix-loop-helix protein 24. class II basic helix-loop-helix protein TCF23. ... Transcription factor 23 (Tcf23), a basic-helix-loop-helix transcription factor, is a new progesterone-induced target gene that ... OUT, a novel basic helix-loop-helix transcription factor with an Id-like inhibitory activity. Narumi O, et al. J Biol Chem, ... The gene encodes a member of the basic helix-loop-helix transcription factor family. Studies of the orthologous gene in mouse ...
https://www.ncbi.nlm.nih.gov/gene/150921
Olig2 MGI Mouse Gene Detail - MGI:1355331 - oligodendrocyte transcription factor 2Olig2 MGI Mouse Gene Detail - MGI:1355331 - oligodendrocyte transcription factor 2
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain. IPR032658 Oligodendrocyte transcription factor 2, basic helix-loop- ... IPR036638 Helix-loop-helix DNA-binding domain superfamily. ... Transcription Start Site. Location. Distance from Gene 5-end. ...
http://www.informatics.jax.org/marker/MGI:1355331
Ribosome Incorporation into Somatic Cells Promotes Lineage Transdifferentiation towards Multipotency | Scientific ReportsRibosome Incorporation into Somatic Cells Promotes Lineage Transdifferentiation towards Multipotency | Scientific Reports
However, the bacterium-intrinsic cellular- transdifferentiation factor remained unknown. Here, we found that cellular ... TWIST family of basic helix-loop-helix transcription factors mediate human mesenchymal stem cell growth and commitment. Stem ... Furthermore, induced pluripotent stem (iPS) cells can be generated by forced expression of specific transcription factors2. A ... 3c), and immunocytochemistry revealed that NANOG and the pluripotent transcription factors POU5F1 (OCT4), SOX2, and SSEA4 were ...
https://www.nature.com/articles/s41598-018-20057-1?error=cookies_not_supported&code=012eee91-1e67-45bc-bcc4-2d568696741b
Biblio | Page 3 | Linus Pauling Institute | Oregon State UniversityBiblio | Page 3 | Linus Pauling Institute | Oregon State University
Basic Helix-Loop-Helix Transcription Factors. Traber MG, Mustacich DJ, Sullivan LC, Leonard SW, Ahern-Rindell A, Kerkvliet N. ...
https://lpi.oregonstate.edu/biblio?f%5Bauthor%5D=5606&o=asc&page=2&s=keyword
Arthur S Lee, Ph.D. | Harvard Catalyst Profiles | Harvard CatalystArthur S Lee, Ph.D. | Harvard Catalyst Profiles | Harvard Catalyst
Basic Helix-Loop-Helix Transcription Factors. 1. 2016. 2016. November 2016. Ossification, Heterotopic. 1. 2016. 2016. November ... Basic Helix-Loop-Helix Transcription Factors. Ossification, Heterotopic. Conserved Sequence. Microfilament Proteins. Zinc. ...
https://connects.catalyst.harvard.edu/Profiles/display/person/162983/network/researchareas/timeline
MMRRC:043392-MUMMRRC:043392-MU
Name: transcription factor 25 (basic helix-loop-helix). Synonyms: 1810041K11Rik, Nulp1, 1100001J13Rik, D8Ertd325e ... Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional ...
https://www.mmrrc.org/catalog/sds.php?mmrrc_id=43392
Multifunctional glial support by Semper cells in the Drosophila retina | PLOS GeneticsMultifunctional glial support by Semper cells in the Drosophila retina | PLOS Genetics
Further, we demonstrate that three factors associated with gliogenesis in vertebrates-prospero/Prox1, Pax2, and Oli/Olig1,2- ... Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors. Neuron. 2000 ... This analysis showed transient expression of the transcription factors Olig1,2/Oli, Rx/Rax, Hes1/dpn, Hes5/E(spl), Hey2/Hey, ... The bHLH transcription factors OLIG2 and OLIG1 couple neuronal and glial subtype specification. Cell. 2002;109: 61-73. pmid: ...
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1006782
Subject: basic-leucine zipper transcription factors / Subject term: basic-leucine zipper transcription factors - PubAg Search...Subject: basic-leucine zipper transcription factors / Subject term: basic-leucine zipper transcription factors - PubAg Search...
... basic helix-loop-helix transcription factors; basic-leucine zipper transcription factors; beta-amylase; carbohydrate content; ... basic-leucine zipper transcription factors Remove constraint Subject: basic-leucine zipper transcription factors Subject term ... basic-leucine zipper transcription factors Remove constraint Subject term: basic-leucine zipper transcription factors Start ... BACKGROUND: The basic leucine zipper (bZIP) transcription factor is one of the most abundant and conserved transcription factor ...
https://pubag.nal.usda.gov/?f%5Bsubject_facet%5D%5B%5D=basic-leucine+zipper+transcription+factors&f%5Bsubject_term%5D%5B%5D=basic-leucine+zipper+transcription+factors&per_page=50&sort=title
Plus itPlus it
2000) Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors. Neuron ... Other transcription factors, including Ying Yang 1 and members of Sox family of transcription factors, including Sox9, Sox10, ... whereas nuclear factor I-A/B and bHLH transcription factors, stem cell leukemia, and KLF15 (Krüppel-like factor 15) were found ... Serum response factor (SRF) is a stimulus-dependent transcription factor required for differentiation and development of ...
https://www.jneurosci.org/content/32/23/8012
Frontiers | Attenuated Negative Feedback in Monocyte-Derived Macrophages From Persons Living With HIV: A Role for IKAROSFrontiers | Attenuated Negative Feedback in Monocyte-Derived Macrophages From Persons Living With HIV: A Role for IKAROS
The mechanism of this reduction in negative feedback involves the attenuated expression of IKZF1, a transcription factor ... The mechanism of this reduction in negative feedback involves the attenuated expression of IKZF1, a transcription factor ... is a basic helix-loop-helix (bHLH) transcription factor (TF) that inhibits other bHLH TFs. Gelsolin (GSN) is an actin-binding ... Transcription Factor PRDII-BF1 Activates Human Immunodeficiency Virus Type 1 Gene Expression. J Virol (1994) 68(2):1002-9. doi ...
https://www.frontiersin.org/articles/10.3389/fimmu.2021.785905/full
IJMS | Free Full-Text | Anaphylaxis: Focus on Transcription Factor ActivityIJMS | Free Full-Text | Anaphylaxis: Focus on Transcription Factor Activity
... focusing on the transcription factors contributions to this systemic hypersensitivity reaction. Host mutation in transcription ... While many molecules are involved in cellular regulation, the expression and regulation of transcription factors involved in ... factor expression, or deregulation of their activity in an anaphylaxis context, will be updated. So far, the risk of ... The MiTF/TFE family of basic helix-loop-helix leucine zipper (b-HLH-LZ) transcription factors includes MITF, TFEB, TFE3, and ...
https://www.mdpi.com/1422-0067/22/9/4935/htm
Recombinant Human DTX1 GST (N-Term) Protein (H00001840-P01): Novus BiologicalsRecombinant Human DTX1 GST (N-Term) Protein (H00001840-P01): Novus Biologicals
... it may play a role in basic helix-loop-helix transcription factor activity. [provided by RefSeq] ...
https://www.novusbio.com/products/dtx1-recombinant-protein_h00001840-p01
Márcia MARGIS-PINHEIRO | Professor (Full) | PhD | Universidade Federal do Rio Grande do Sul, Porto Alegre | UFRGS |...Márcia MARGIS-PINHEIRO | Professor (Full) | PhD | Universidade Federal do Rio Grande do Sul, Porto Alegre | UFRGS |...
We have characterised the role of OsICE1, a basic helix-loop-helix (bHLH) transcription factor from rice (Oryza sativa L.), in ... In this study, we focus on the functional characterization of OsbHLH35, a basic Helix-Loop-Helix (bHLH) TF that regulates ... Growth Regulating Factors (GRFs) comprise a transcription factor family with important functions in plant growth and ... OsICE1 transcription factor improves photosynthetic performance and reduces grain losses in rice plants subjected to drought ...
https://www.researchgate.net/profile/Marcia-Margis-Pinheiro
Sex related expressivity of the phenotype in coronal craniosynostosis caused by the recurrent P250R FGFR3 mutation | Journal of...Sex related expressivity of the phenotype in coronal craniosynostosis caused by the recurrent P250R FGFR3 mutation | Journal of...
1997) Mutations in TWIST, a basic helix-loop-helix transcription factor, in Saethre-Chotzen syndrome. Nat Genet 15:36-41. ... 1997) Prevalence of Pro250Arg mutation of fibroblast growth factor receptor 3 in coronal craniosynostosis. Lancet 349:1059-1062 ... 1997) A unique point mutation in the fibroblast growth factor receptor 3 (FGFR3) gene defines a new craniosynostosis syndrome. ... A recurrent point mutation in the fibroblast growth factor receptor 3 (FGFR3) gene that converts proline 250 into arginine is ...
https://jmg.bmj.com/content/36/1/9
Lateral line placodes of aquatic vertebrates are evolutionarily conserved in mammals | Biology Open | The Company of BiologistsLateral line placodes of aquatic vertebrates are evolutionarily conserved in mammals | Biology Open | The Company of Biologists
... a proneural gene of the basic helix-loop-helix (bHLH) family of transcription factors. Accordingly, Ngn1+ neuroblasts were ... A mammalian helix-loop-helix factor structurally related to the product of Drosophila proneural gene atonal is a positive ... 4G-I). This T-box transcription factor is specifically upregulated in the lateral line placodes of anamniotes (Schlosser, 2006 ... neurogenins, a novel family of atonal-related bHLH transcription factors, are putative mammalian neuronal determination genes ...
https://journals.biologists.com/bio/article/7/6/bio031815/1943/Lateral-line-placodes-of-aquatic-vertebrates-are
NIOSHTIC-2 Search Results - Full View
HIF-1 is a heterodimeric basic helix-loop-helix transcription factor, composed of HIF-1alpha and HIF-1beta/ARNT subunits; and ... In this study, we investigated whether arsenite induces expression of hypoxia-inducible factor 1 (HIF-1). ...
http://www2a.cdc.gov/nioshtic-2/BuildQyr.asp?s1=skin&t3=1&f1=%2A&s5=percutaneous&Startyear=&t1=1&s2=dermal&t4=1&terms=7&Adv=1&ct=&B1=Search&f2=%2A&t2=1&Limit=500&Sort=DP+DESC&s3=dermatitis&f3=%2A&s4=cutaneous&EndYear=&f4=%2A&f5=%2A&whichdate=DP&D1=10&PageNo=194&RecNo=1935&View=f&
Kaninchen HIF1A ELISA Kit | Produkt Nr. ABIN6956648Kaninchen HIF1A ELISA Kit | Produkt Nr. ABIN6956648
Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) ELISA Kit Small Sample HIF1A ... Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) ELISA Kit HIF1A Reaktivität: ... Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) ELISA Kit HIF1A Reaktivität: ... Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) ELISA Kit HIF1A Reaktivität: ...
https://www.antikoerper-online.de/kit/6956648/Hypoxia+Inducible+Factor+1,+alpha+Subunit+Basic+Helix-Loop-Helix+Transcription+Factor+HIF1A+ELISA+Kit/
EVPP Departments - Scholarly Works - Arizona State University
Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature. Skinner, M. K., Rawls, A., Wilson-Rawls ...
https://asu.pure.elsevier.com/en/organisations/evpp-departments-2/publications/?type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontojournal%2Fsystematicreview
Table of Contents - September 01, 2021, 8 (5) | eNeuroTable of Contents - September 01, 2021, 8 (5) | eNeuro
Isoform-Specific Reduction of the Basic Helix-Loop-Helix Transcription Factor TCF4 Levels in Huntingtons Disease Kaja Nurm, ... The Type 2 Diabetes Factor Methylglyoxal Mediates Axon Initial Segment Shortening and Alters Neuronal Function at the Cellular ...
https://www.eneuro.org/content/8/5
A structural variant in the 5-flanking region of the TWIST2 gene affects melanocyte development in belted cattle | PLOS ONEA structural variant in the 5'-flanking region of the TWIST2 gene affects melanocyte development in belted cattle | PLOS ONE
TWIST2 is a basic helix loop helix (bHLH) transcription factor with a postulated role in early development influencing ... 1993) Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix ... bHLH transcription factors are known to dimerize via their bHLH domain and each monomer binds to one halfsite of the DNA ... MITF is also a bHLH transcription factor absolutely required for the development of melanocytes. TWIST2 has been reported to ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0180170
Xenbase ImageXenbase Image
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)) gene expression in Xenopus laevis ...
https://www.xenbase.org/entry/showImage.do?imageId=138008&printer=true
Scientific Publications since 2002 | Max Planck Institute for Plant Breeding ResearchScientific Publications since 2002 | Max Planck Institute for Plant Breeding Research
Heim, M. A.; Jakoby, M.; Werber, M.; Martin, C.; Weisshaar, B.; Bailey, P. C.: The basic helix-loop-helix transcription factor ... Update on the basic helix-loop-helix transcription factor gene family in Arabidopsis thaliana. Plant Cell 15 (11), pp. 2497 - ... A systematic survey in Arabidopsis thaliana of transcription factors that modulate circadian parameters. BMC Genomics 9, p. 182 ...
https://www.mpipz.mpg.de/publication-search/13613?person=%2Fpersons%2Fresource%2Fpersons40036
GenAge Human Genes: List of EntriesGenAge Human Genes: List of Entries
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor). 17. 62. ... heat shock transcription factor 1. 23. 31. HSP90AA1. 74. heat shock protein 90kDa alpha (cytosolic), class A member 1. 10. 133 ... nuclear factor, erythroid 2-like 2. 7. 36. NFKB1. 82. nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. 25 ... eukaryotic translation elongation factor 1 alpha 1. 5. 43. EEF1E1. 266. eukaryotic translation elongation factor 1 epsilon 1. 3 ...
https://genomics.senescence.info/genes/allgenes.php
Leucine zipperBHLH transcriptionGenesProteinsProteinMetabolismArabidopsisRegulateCellsBindEndogenousOligodendrocyteEpithelialGene familyModulateOlig1FAMILYGerminationInhibitoryDroughtFibroblastNeuralExpressionCellularMutationsStemRegionPrimordiaActivityDevelopmentRoleRegulationDifferentiationSpecific
Leucine zipper4
  • The MITF gene encodes a transcription factor containing a basic-helix-loop-helix-leucine zipper. (medscape.com)
  • Basic region/leucine zipper (bZIP) transcription factors play important roles in the abscisic acid (ABA) signaling pathway and abiotic stress response in plants. (usda.gov)
  • TFE3 is a ubiquitously expressed 50 kDa transcription factor containing both basic helix-loop-helix (bHLH) and leucine zipper (ZIP) motifs. (bdbiosciences.com)
  • This process is mainly determined by the actions of microphthalmia-associated transcription factor (MITF), a basic-helix-loop-helix and leucine zipper transcription factor, which functions as the master gene for melanocyte survival. (cosmeticsandtoiletries.com)
BHLH transcription6
  • Specifically, the TWIST1 protein is part of a large protein family called basic helix-loop-helix (bHLH) transcription factors. (medlineplus.gov)
  • It was reported that the basic helix-loop-helix ( bHLH ) transcription factors play vital roles in the process of chlorophyll metabolism. (biomedcentral.com)
  • Basic Helix-Loop-Helix ( bHLH ) transcription factor family is the second largest gene families in plant kingdom, usually classified into 15-26 subfamilies. (biomedcentral.com)
  • BHLH transcription factors have a highly conserved bHLH domain with ∼ 60 amino acids, which comprises a basic region followed by two amphipathic α-helices separated by a variable loop region (HLH) [ 5 ]. (biomedcentral.com)
  • Basic helix-loop-helix (bHLH) transcription factors regulate various aspects of tissue development, and we have previously identified a bHLH transcription factor, AmeloD, from a tooth germ cDNA library. (jbc.org)
  • achaete-scute family bHLH transcription. (wikigenes.org)
Genes9
  • This protein is a transcription factor, which means that it attaches (binds) to specific regions of DNA and controls the activity of particular genes. (medlineplus.gov)
  • However, mutations in genes encoding α subunits of hypoxia-inducible factors (HIF-α) have not previously been identified in any cancer. (nih.gov)
  • The genes up-regulated by this transcription factor during embryogenesis have not been identified. (medscape.com)
  • Innate host defense requires TFEB-mediated transcription of cytoprotective and antimicrobial genes. (umassmed.edu)
  • The basic region is relevant to the DNA binding that allows the bHLH proteins binding to the cis-acting elements in the promoter regions of the target genes, and the HLH region functions as a dimerization domain that allows the formation of homo- and/or heterodimers. (biomedcentral.com)
  • Some of these factors implicated in retinal development and regeneration are members of the Hairy/Enhancer of Split (Hes) superfamily of genes, including the Hairy-related (Her) factors Her4 and Her9. (uky.edu)
  • Her transcription factors are basic-helix-loop-helix-orange (bHLH-O) transcription factors that bind to palindromic E- and N-box canonical sequences in the promoters of target genes. (uky.edu)
  • Many transcription factors and genes related to the photoperiod and GA pathways, floral organ identity, and the anthocyanin biosynthesis pathway were differentially expressed between the normal and mutant capitula. (researchsquare.com)
  • It represses GENETIC TRANSCRIPTION of target genes by recruiting HISTONE DEACETYLASES . (nih.gov)
Proteins5
  • Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening. (nih.gov)
  • These include ion-transport proteins (Na/K+-ATPase, Eaat1, and Kir4.1-related channels) and metabolic homeostatic factors (dLDH and Glut1). (plos.org)
  • It also is a key factor in regulating the transcription of the major melanogenic proteins, including tyrosinase and tyrosinase-related proteins (TRP) 1 and 2, which lead to pigmentation. (cosmeticsandtoiletries.com)
  • These results support the hypothesis that the evolutionarily unrelated blue-light receptors, cryptochrome and LOV-domain F-box proteins, mediate blue-light regulation of the same transcription factor by distinct mechanisms. (escholarship.org)
  • In the CYTOPLASM , I-kappa B proteins bind to the transcription factor NF-KAPPA B. Cell stimulation causes its dissociation and translocation of active NF-kappa B to the nucleus. (bvsalud.org)
Protein4
  • Studies of the orthologous gene in mouse have shown the encoded protein does not bind DNA but may negatively regulate other basic helix-loop-helix factors via the formation of a functionally inactive heterodimeric complex. (nih.gov)
  • Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. (novusbio.com)
  • The basic helix-loop-helix transcription factor family in plants: A genome-wide study of protein structure and functional diversity. (mpg.de)
  • In this study we present a variety of automated methods for visualisation of a protein-protein interaction network, using the basic helix-loop-helix (bHLH) family of transcription factors as an example. (sciweavers.org)
Metabolism1
  • TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop. (umassmed.edu)
Arabidopsis4
  • A systematic survey in Arabidopsis thaliana of transcription factors that modulate circadian parameters. (mpg.de)
  • Update on the basic helix-loop-helix transcription factor gene family in Arabidopsis thaliana. (mpg.de)
  • Arabidopsis CRY2 and ZTL mediate blue-light regulation of the transcription factor CIB1 by distinct mechanisms. (escholarship.org)
  • In Arabidopsis, the photoexcited cryptochrome 2 interacts with the transcription factor CRYPTOCHROME-INTERACTING basic helix-loop-helix 1 (CIB1) to activate transcription and floral initiation. (escholarship.org)
Regulate3
  • The bHLH family of transcription factors helps regulate the development of many organs and tissues before birth. (medlineplus.gov)
  • The SOX10 gene encodes a member of the high-mobility group-domain Sox family of transcription factors that regulate neural crest development. (medscape.com)
  • May also negatively regulate bHLH-mediated transcription through an N-terminal repressor domain. (nih.gov)
Cells8
  • Capsulin is a basic helix-loop-helix transcription factor expressed in mesenchymal cells that encapsulate the epithelial primordia of internal organs, including the kidney and lung, as well as the epicardium, which gives rise to the coronary arteries. (elsevier.com)
  • A murine uterine transcriptome, responsive to steroid receptor coactivator-2, reveals transcription factor 23 as essential for decidualization of human endometrial stromal cells. (nih.gov)
  • Furthermore, induced pluripotent stem (iPS) cells can be generated by forced expression of specific transcription factors 2 . (nature.com)
  • Bacteria have been shown to affect human cellular differentiation, but the developmental effect of bacteria remains unclear because the bacterium-intrinsic transforming factors that covert somatic cells into cells that can differentiate into the three germ layers have not been identified. (nature.com)
  • Specifically, we show that distinct support functions (neuronal activity, structural integrity and sustained neurotransmission) can be genetically separated in cone cells by down-regulating transcription factors associated with vertebrate gliogenesis ( pros/Prox1 , Pax2/5/8 , and Oli/Olig1 , 2 , respectively). (plos.org)
  • Further, we find that specific factors critical for glial function in other species are also critical in cone cells to support Drosophila photoreceptor activity. (plos.org)
  • Here we show that deletion of the stimulus-dependent transcription factor, serum response factor (SRF), in neural precursor cells (NPCs) ( Srf -Nestin-cKO) results in nearly 60% loss in astrocytes and 50% loss in oligodendrocyte precursors at birth. (jneurosci.org)
  • Cells were fixed and permeabilized with Transcription Factor Staining Buffer Kit (PF00011). (ptglab.com)
Bind1
  • They bind with basic helix-loop-helix (bHLH) type TRANSCRIPTION FACTORS . (nih.gov)
Endogenous2
  • We show that repression of germination by FR light involves stabilized DELLA factors GAI, RGA and RGL2 that stimulate endogenous ABA synthesis. (unige.ch)
  • Flowering, which is a key developmental process in the plant life cycle, is a very complex process controlled by endogenous factors and environmental cues. (researchsquare.com)
Oligodendrocyte1
  • Previous studies have widely characterized the signaling pathways important for astrocyte differentiation and unveiled a number of transcription factors that guide oligodendrocyte differentiation in the CNS. (jneurosci.org)
Epithelial2
  • Transcription factor TFEB cell-autonomously modulates susceptibility to intestinal epithelial cell injury in vivo. (umassmed.edu)
  • The change in the epithelial and mesenchymal gene expression that occurs during EMT is regulated by multiple transcription factor families, including SNAI1/Snail, ZEB1/ZEB2, and basic helix-loop-helix transcription factors (bHLH). (abcam.com)
Gene family1
  • 1 Phenotypically distinct entities including Crouzon, Apert, Pfeiffer, and Jackson-Weiss syndromes have been ascribed to mutations in three members of the fibroblast growth factor receptors (FGFRs) gene family, while mutations in the TWIST gene specifically account for the Saethre-Chotzen syndrome. (bmj.com)
Modulate1
  • To determine the possible roles of her4 and her9 factors in the retina, I characterized the expression patterns of these factors during developmental retinal neurogenesis and/or regeneration, examined loss of function phenotypes, and identified signaling pathways that modulate expression of these factors. (uky.edu)
Olig11
  • Further, we demonstrate that three factors associated with gliogenesis in vertebrates- prospero/Prox1 , Pax2 , and Oli/Olig1 , 2 -control genetically distinct aspects of these support functions. (plos.org)
FAMILY3
  • The gene encodes a member of the basic helix-loop-helix transcription factor family. (nih.gov)
  • It has also been reported that deficiency in Nkx2-3 , encoding a member of the NK2 homeobox family of transcription factors, leads to cusp absence in affected teeth. (jbc.org)
  • A family of DNA -binding transcription factors that contain a basic HELIX-LOOP-HELIX MOTIF. (bvsalud.org)
Germination1
  • In turn, ABA blocks germination through the transcription factor ABI3. (unige.ch)
Inhibitory1
  • OUT, a novel basic helix-loop-helix transcription factor with an Id-like inhibitory activity. (nih.gov)
Drought1
  • In response to environmental stresses, fluctuations in the expression of miRNAs can be induced by many uncontrolled factors, such as drought, salinity, and alkalinity at transcriptional and post-transcriptional levels. (biomedcentral.com)
Fibroblast3
  • Apert, Pfeiffer, Jackson-Weiss, and Crouzon syndromes result from mutations in the fibroblast growth factor receptor-2 ( FGFR2 ) gene, which maps to band 10q25-q26. (medscape.com)
  • Some patients with Pfeiffer syndrome have demonstrated mutations in the fibroblast growth factor receptor-1 ( FGFR1 ) gene, which maps to band 8p11.2-12. (medscape.com)
  • A recurrent point mutation in the fibroblast growth factor receptor 3 (FGFR3) gene that converts proline 250 into arginine is commonly associated with coronal craniosynostosis and has allowed definition of a new syndrome on a molecular basis. (bmj.com)
Neural1
  • Her factors have been previously shown to play roles in a diverse array of developmental and neurogenic processes, including neural tube closure, floor plate development, somitogenesis, and development of various components of the central nervous system as well as the cranial sensory placodes. (uky.edu)
Expression5
  • A census of human transcription factors: function, expression and evolution. (nih.gov)
  • Interestingly, ectopic expression of a constitutively active SRF (SRF-VP16) in NPCs augmented astrocyte differentiation in the presence of pro-astrocytic factors. (jneurosci.org)
  • The mechanism of this reduction in negative feedback involves the attenuated expression of IKZF1, a transcription factor required for de novo synthesis of RELA during LPS-induced inflammatory responses. (frontiersin.org)
  • In this study, we investigated whether arsenite induces expression of hypoxia-inducible factor 1 (HIF-1). (cdc.gov)
  • All of these processes rely on the tight coordination of extrinsic and intrinsic cues, as well as regulation of gene expression by transcription factors. (uky.edu)
Cellular1
  • However, the bacterium-intrinsic cellular- transdifferentiation factor remained unknown. (nature.com)
Mutations1
  • Here we report two novel somatic gain-of-function mutations in the gene encoding hypoxia-inducible factor 2α (HIF2A) in two patients, one presenting with paraganglioma and the other with paraganglioma and somatostatinoma, both of whom had polycythemia. (nih.gov)
Stem1
  • The proliferation and differentiation of melanocytes are believed to be regulated by the keratinocyte-derived factors α-MSH, adrenocorticotropic hormone (ACTH), stem cell factor (SCF) and endothelin-1 (ET-1) (see Figure 4 ). (cosmeticsandtoiletries.com)
Region1
  • Binding results in transcriptional activation and is mediated through the basic region located just N-terminal to the HLH domain. (bdbiosciences.com)
Primordia1
  • One of the first steps once plants are committed to flowering is the induction of the plant-specific transcription factor LEAFY in the incipient flower primordia. (upsc.se)
Activity1
  • however, it may play a role in basic helix-loop-helix transcription factor activity. (novusbio.com)
Development3
  • The PAX3 gene encodes a transcription factor with a paired box domain, an octapeptide domain, and a homeobox domain essential for survival of melanocytes during development. (medscape.com)
  • Although a considerable amount of work has been conducted to identify key regulators of retinal development and regeneration, many gene regulatory networks which include both master signaling pathways as well as individual transcription factors remain poorly characterized. (uky.edu)
  • The mutated gene, PORCUPINE , encodes a putative splice factor, suggesting that alternative splicing of pre-mRNA might be involved in modulating growth and development in response to changes in ambient temperature and might contribute to establish phenotypic plasticity in plants. (upsc.se)
Role1
  • E-boxes play a regulatory role in the control of transcription. (nih.gov)
Regulation1
  • There is increasing evidence that microRNAs (miRNAs), ~21 nucleotides (nt) in length, act as key factors in gene regulation, developmental processes and stress tolerance in plants [ 3 - 5 ]. (biomedcentral.com)
Differentiation1
  • However, SRF-deficient NPCs generated fewer astrocytes and oligodendrocytes in response to several lineage-specific differentiation factors. (jneurosci.org)
Specific1
  • The gene for alpha-MSH is encoded for by the POMC gene, but alpha-MSH cannot be produced from POMC gene transcription and translation without these specific post-translational proteolytic steps taking place. (embl-heidelberg.de)
TWIST1 gene: MedlinePlus Genetics
TWIST1 gene: MedlinePlus Genetics (medlineplus.gov)
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EVPP Departments - Scholarly Works - Arizona State University
EVPP Departments - Scholarly Works - Arizona State University (asu.pure.elsevier.com)
GenAge Human Genes: List of Entries
GenAge Human Genes: List of Entries (genomics.senescence.info)
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Table of Contents - September 01, 2021, 8 (5) | eNeuro
Table of Contents - September 01, 2021, 8 (5) | eNeuro (eneuro.org)
Xenbase Image
Xenbase Image (xenbase.org)
Scientific Publications since 2002 | Max Planck Institute for Plant Breeding Research
Scientific Publications since 2002 | Max Planck Institute for Plant Breeding Research (mpipz.mpg.de)
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