Helix-Loop-Helix Motifs
Basic Helix-Loop-Helix Transcription Factors
Inhibitor of Differentiation Proteins
Hepatocyte Nuclear Factor 3-beta
Hepatocyte Nuclear Factor 3-gamma
Hepatocyte Nuclear Factor 3-alpha
Forkhead Transcription Factors
Transcription Factors
Winged-Helix Transcription Factors
DNA-Binding Proteins
Gene Expression Regulation, Developmental
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Transcription, Genetic
Nuclear Proteins
Base Sequence
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Cell Differentiation
Mice, Transgenic
Mice, Knockout
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Promoter Regions, Genetic
T-Lymphocytes, Regulatory
Helix (Snails)
Amino Acid Sequence
Binding Sites
Sp1 Transcription Factor
Gene Expression Regulation
Protein Binding
Transcriptional Activation
Trans-Activators
Protein Structure, Secondary
Mutation
DNA
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Models, Molecular
Protein Structure, Tertiary
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
Repressor Proteins
Transcription Factor AP-1
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Homeodomain Proteins
Basic-Leucine Zipper Transcription Factors
Transfection
Cell Nucleus
Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
Transcription Factor AP-2
Transcription Factors, TFII
The so-called general transcription factors that bind to RNA POLYMERASE II and that are required to initiate transcription. They include TFIIA; TFIIB; TFIID; TFIIE; TFIIF; TFIIH; TFII-I; and TFIIJ. In vivo they apparently bind in an ordered multi-step process and/or may form a large preinitiation complex called RNA polymerase II holoenzyme.
Kruppel-Like Transcription Factors
HeLa Cells
Genes, Reporter
Sequence Homology, Amino Acid
Cells, Cultured
Nucleic Acid Conformation
Chromatin Immunoprecipitation
A technique for identifying specific DNA sequences that are bound, in vivo, to proteins of interest. It involves formaldehyde fixation of CHROMATIN to crosslink the DNA-BINDING PROTEINS to the DNA. After shearing the DNA into small fragments, specific DNA-protein complexes are isolated by immunoprecipitation with protein-specific ANTIBODIES. Then, the DNA isolated from the complex can be identified by PCR amplification and sequencing.
Recombinant Fusion Proteins
Cloning, Molecular
YY1 Transcription Factor
STAT3 Transcription Factor
Transcription Factor TFIID
The major sequence-specific DNA-binding component involved in the activation of transcription of RNA POLYMERASE II. It was originally described as a complex of TATA-BOX BINDING PROTEIN and TATA-BINDING PROTEIN ASSOCIATED FACTORS. It is now know that TATA BOX BINDING PROTEIN-LIKE PROTEINS may take the place of TATA-box binding protein in the complex.
GATA4 Transcription Factor
Plasmids
Mutagenesis, Site-Directed
Zinc Fingers
Motifs in DNA- and RNA-binding proteins whose amino acids are folded into a single structural unit around a zinc atom. In the classic zinc finger, one zinc atom is bound to two cysteines and two histidines. In between the cysteines and histidines are 12 residues which form a DNA binding fingertip. By variations in the composition of the sequences in the fingertip and the number and spacing of tandem repeats of the motif, zinc fingers can form a large number of different sequence specific binding sites.
Activating Transcription Factor 3
Reverse Transcriptase Polymerase Chain Reaction
NFATC Transcription Factors
A family of transcription factors characterized by the presence of highly conserved calcineurin- and DNA-binding domains. NFAT proteins are activated in the CYTOPLASM by the calcium-dependent phosphatase CALCINEURIN. They transduce calcium signals to the nucleus where they can interact with TRANSCRIPTION FACTOR AP-1 or NF-KAPPA B and initiate GENETIC TRANSCRIPTION of GENES involved in CELL DIFFERENTIATION and development. NFAT proteins stimulate T-CELL activation through the induction of IMMEDIATE-EARLY GENES such as INTERLEUKIN-2.
A conserved motif in goosecoid mediates groucho-dependent repression in Drosophila embryos. (1/5432)
Surprisingly small peptide motifs can confer critical biological functions. One example is the WRPW tetrapeptide present in the Hairy family of transcriptional repressors, which mediates recruitment of the Groucho (Gro) corepressor to target promoters. We recently showed that Engrailed (En) is another repressor that requires association with Gro for its function. En lacks a WRPW motif; instead, it contains another short conserved sequence, the En homology region 1 (eh1)/GEH motif, that is likely to play a role in tethering Gro to the promoter. Here, we characterize a repressor domain from the Goosecoid (Gsc) developmental regulator that includes an eh1/GEH-like motif. We demonstrate that this domain (GscR) mediates efficient repression in Drosophila blastoderm embryos and that repression by GscR requires Gro function. GscR and Gro interact in vitro, and the eh1/GEH motif is necessary and sufficient for the interaction and for in vivo repression. Because WRPW- and eh1/GEH-like motifs are present in different proteins and in many organisms, the results suggest that interactions between short peptides and Gro represent a widespread mechanism of repression. Finally, we investigate whether Gro is part of a stable multiprotein complex in the nucleus. Our results indicate that Gro does not form stable associations with other proteins but that it may be able to assemble into homomultimeric complexes. (+info)Physical interaction of the bHLH LYL1 protein and NF-kappaB1 p105. (2/5432)
The LYL1 gene was first identified upon the molecular characterization of the t(7;9)(q35;p13) translocation associated with some human T-cell acute leukemias (T-ALLs). In adult tissues, LYL1 expression is restricted to hematopoietic cells with the notable exclusion of the T cell lineage. LYL1 encodes a basic helix-loop-helix (bHLH) protein highly related to TAL-1, whose activation is also associated with a high proportion of human T-ALLs. A yeast two-hybrid system was used to identify proteins that specifically interact with LYL1 and might mediate its activities. We found that p105, the precursor of NF-kappaB1 p50, was the major LYL1-interacting protein in this system. The association between LYL1 and p105 was confirmed both in vitro and in vivo in mammalian cells. Biochemical studies indicated that the interaction was mediated by the bHLH motif of LYL1 and the ankyrin-like motifs of p105. Ectopic expression of LYL1 in a human T cell line caused a significant decrease in NF-kappaB-dependent transcription, associated with a reduced level of NF-kappaB1 proteins. (+info)A molecular pathway revealing a genetic basis for human cardiac and craniofacial defects. (3/5432)
Microdeletions of chromosome 22q11 are the most common genetic defects associated with cardiac and craniofacial anomalies in humans. A screen for mouse genes dependent on dHAND, a transcription factor implicated in neural crest development, identified Ufd1, which maps to human 22q11 and encodes a protein involved in degradation of ubiquitinated proteins. Mouse Ufd1 was specifically expressed in most tissues affected in patients with 22q11 deletion syndrome. The human UFD1L gene was deleted in all 182 patients studied with 22q11 deletion, and a smaller deletion of approximately 20 kilobases that removed exons 1 to 3 of UFD1L was found in one individual with features typical of 22q11 deletion syndrome. These data suggest that UFD1L haploinsufficiency contributes to the congenital heart and craniofacial defects seen in 22q11 deletion. (+info)Expression of Mash1 in basal cells of rat circumvallate taste buds is dependent upon gustatory innervation. (4/5432)
Mash1, a mammalian homologue of the Drosophila achaete-scute proneural gene complex, plays an essential role in differentiation of subsets of peripheral neurons. In this study, using RT-PCR and in situ RT-PCR, we investigated if Mash1 gene expression occurs in rat taste buds. Further, we examined dynamics of Mash1 expression in the process of degeneration and regeneration in denervated rat taste buds. In rat tongue epithelium, Mash1 gene expression is confined to circumvallate, foliate, and fungiform papilla epithelia that include taste buds. In taste buds, Mash1-expressing cells are round cells in the basal compartment. In contrast, the mature taste bud cells do not express the Mash1 gene. Denervation and regeneration experiments show that the expression of Mash1 requires gustatory innervation. We conclude that Mash1 is expressed in cells of the taste bud lineage, and that the expression of Mash1 in rat taste buds is dependent upon gustatory innervation. (+info)Dynamic expression of lunatic fringe suggests a link between notch signaling and an autonomous cellular oscillator driving somite segmentation. (5/5432)
The metameric organization of the vertebrate trunk is a characteristic feature of all members of this phylum. The origin of this metamerism can be traced to the division of paraxial mesoderm into individual units, termed somites, during embryonic development. Despite the identification of somites as the first overt sign of segmentation in vertebrates well over 100 years ago, the mechanism(s) underlying somite formation remain poorly understood. Recently, however, several genes have been identified which play prominent roles in orchestrating segmentation, including the novel secreted factor lunatic fringe. To gain further insight into the mechanism by which lunatic fringe controls somite development, we have conducted a thorough analysis of lunatic fringe expression in the unsegmented paraxial mesoderm of chick embryos. Here we report that lunatic fringe is expressed predominantly in somite -II, where somite I corresponds to the most recently formed somite and somite -I corresponds to the group of cells which will form the next somite. In addition, we show that lunatic fringe is expressed in a highly dynamic manner in the chick segmental plate prior to somite formation and that lunatic fringe expression cycles autonomously with a periodicity of somite formation. Moreover, the murine ortholog of lunatic fringe undergoes a similar cycling expression pattern in the presomitic mesoderm of somite stage mouse embryos. The demonstration of a dynamic periodic expression pattern suggests that lunatic fringe may function to integrate notch signaling to a cellular oscillator controlling somite segmentation. (+info)The development and evolution of bristle patterns in Diptera. (6/5432)
The spatial distribution of sensory bristles on the notum of different species of Diptera is compared. Species displaying ancestral features have a simple organization of randomly distributed, but uniformly spaced, bristles, whereas species thought to be more derived bear patterns in which the bristles are aligned into longitudinal rows. The number of rows of large bristles on the scutum was probably restricted to four early on in the evolution of cyclorraphous Brachyceran flies. Most species have stereotyped patterns based on modifications of these four rows. The possible constraints placed upon the patterning mechanisms due to growth and moulting within the Diptera are discussed, as well as within hemimetabolous insects. The holometabolic life cycle and the setting aside of groups of imaginal cells whose function is not required during the growth period, may have provided the freedom necessary for the evolution of elaborate bristle patterns. We briefly review the current state of knowledge concerning the complex genetic pathways regulating achaete-scute gene expression and bristle pattern in Drosophila melanogaster, and consider mechanisms for the genetic regulation of the bristle patterns of other species of Diptera. (+info)Bar homeobox genes are latitudinal prepattern genes in the developing Drosophila notum whose expression is regulated by the concerted functions of decapentaplegic and wingless. (7/5432)
In Drosophila notum, the expression of achaete-scute proneural genes and bristle formation have been shown to be regulated by putative prepattern genes expressed longitudinally. Here, we show that two homeobox genes at the Bar locus (BarH1 and BarH2) may belong to a different class of prepattern genes expressed latitudinally, and suggest that the developing notum consists of checker-square-like subdomains, each governed by a different combination of prepattern genes. BarH1 and BarH2 are coexpressed in the anterior-most notal region and regulate the formation of microchaetae within the region of BarH1/BarH2 expression through activating achaete-scute. Presutural macrochaetae formation also requires Bar homeobox gene activity. Bar homeobox gene expression is restricted dorsally and posteriorly by Decapentaplegic signaling, while the ventral limit of the expression domain of Bar homeobox genes is determined by wingless whose expression is under the control of Decapentaplegic signaling. (+info)Dual role of extramacrochaetae in cell proliferation and cell differentiation during wing morphogenesis in Drosophila. (8/5432)
The Extramacrochaetae (emc) gene encodes a transcription factor with an HLH domain without the basic region involved in interaction with DNA present in other proteins that have this domain. EMC forms heterodimers with bHLH proteins preventing their binding to DNA, acting as a negative regulator. The function of emc is required in many developmental processes during the development of Drosophila, including wing morphogenesis. Mitotic recombination clones of both null and gain-of-function alleles of emc, indicate that during wing morphogenesis, emc participates in cell proliferation within the intervein regions (vein patterning), as well as in vein differentiation. The study of relationships between emc and different genes involved in wing development reveal strong genetic interactions with genes of the Ras signalling pathway (torpedo, vein, veinlet and Gap), blistered, plexus and net, in both adult wing phenotypes and cell behaviour in genetic mosaics. These interactions are also analyzed as variations of emc expression patterns in mutant backgrounds for these genes. In addition, cell proliferation behaviour of emc mutant cells varies depending on the mutant background. The results show that genes of the Ras signalling pathway are co-operatively involved in the activity of emc during cell proliferation, and later antagonistically during cell differentiation, repressing EMC expression. (+info)
Genome-wide analysis of basic/helix-loop-helix transcription factor family in rice and Arabidopsis<...
The basic helix-loop-helix transcription factor neuroD is expressed in the rod lineage of the teleost retina. - PubMed - NCBI
Proneural genetic programs include genes required for asymmetric cell division in drosophila
The bHLH transcription factor hand2 is essential for noradrenergic differentiation of sympathetic neurons | Development
Phosphorylation in intrinsically disordered regions regulates the activity of
Neurogenin2. - Tufts Digital...
Examination of mammalian basic helix-loop-helix transcription factors using a yeast one-hybrid system
JAIRO | Conformational changes in inhibitory PAS domain protein associated with binding of HIF-1α and Bcl-xL in living cells.
Neurogenin-3 - Wikipedia
HIF1A - Hypoxia inducible factor 1, alpha subunit (Basic helix-loop-helix transcription factor) - Bos taurus (Bovine) - HIF1A...
Distinct domains within Mash1 and Math1 are required for function in neuronal differentiation versus neuronal cell-type...
endothelial PAS domain-containing protein 1
Summary Report | CureHunter
Pro-Photoreceptor Activity of Chick neurogenin1 | IOVS | ARVO Journals
ATOH1 - ويكيبيديا
Mammalian BarH homologue is a potential regulator of neural bHLH genes.
Abstract 14: The Helix-Loop-Helix Transcription Factor nPAS4 Induces Sprouting Angiogenesis and Regulates Tip Cell Formation |...
Genetic risk expressed in early regulator of gene expression | Genes 2 Brains 2 Mind 2 Me
Proneural genes - Wikipedia
Transcription Factor 3
Summary Report | CureHunter
The bHLH factors, dHAND and eHAND, specify pulmonary and systemic cardiac ventricles independent of left-right sidedness
HEA798Hu | 低氧诱导因子1α(HIF1a)检测试剂盒(酶联免疫吸附试验法,高敏型) | Homo sapiens (Human,人) USCN(武汉优尔生商贸有限公司)
Differential genomic targeting of the transcription factor TAL1 in alternate haematopoietic lineages | The EMBO Journal
Cell cycle switch to endocycle: the nucleolus lends a hand. - Physiology, Anatomy and Genetics
Serotonin-Expressing Cells in the Corpus of the Stomach Originate from by Brian T. Johnston
Most recent papers with the keyword ngn2 | Read by QxMD
Human eHAND, but not dHAND, is down-regulated in cardiomyopathies<...
RePub, Erasmus University Repository:
ETO2 coordinates cellular proliferation and differentiation during erythropoiesis
Gene Expression Literature Detail
Transcription Factor 4 (TCF4) Antibody | Abbexa Ltd
Plus it
Expression pattern of the stem cell leukaemia gene in the CNS of the embryonic and adult mouse. - Semantic Scholar
HEY1 hes related family bHLH transcription factor with YRPW motif 1 [Homo sapiens (human)] - Gene - NCBI
HEY1 elisa kit | Dog hairy/enhancer-of-split related with YRPW motif 1 ELISA Kit-NP 001002953.1
Gene Expression Literature Detail
HIF-2 alpha/EPAS1 Antibody (ep190b) [HRP] (NB100-132H): Novus Biologicals
anti-ATOH8 antibody | GeneTex
ASCL2 (achaete-scute family bHLH transcription factor 2) - KOMP (Knockout Mouse Project)
Art of Problem Solving
Art of Problem Solving
Neuronal PAS domain-containing protein 3
Investigating the role for c-myc and bHLH transcription factors in driving phenotypic versatility of cancer stem cells in...
Npas2 - Neuronal PAS domain-containing protein 2 - Mus musculus (Mouse) - Npas2 gene & protein
Atoh8 gene cDNA ORF clone, Mus musculus(house mouse) - GenScript
Nanomaterials | Free Full-Text | Neurogenic Differentiation of Human Dental Pulp Stem Cells on Graphene-Polycaprolactone Hybrid...
Neuronal PAS domain protein 4 (Npas4) controls neuronal homeostasis in pentylenetetrazole-induced epilepsy through the...
Myc Proto Oncogene Protein (Transcription Factor p64 or Class E Basic Helix Loop Helix Protein 39 or MYC) - Pipeline Review, H2...
Mitogen-activated protein kinase phosphorylates and negatively regulates basic helix-loop-helix-PAS transcription factor BMAL1 ...
Genome-Wide Identification and Analysis of the Chicken Basic Helix-Loop-Helix Factors
Class E basic helix-loop-helix protein 23
Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3 -...
Anti-Human Olig2 Antibody | Human Olig2 Antibody | Olig2 Antibody
Anti-Human Olig2 Antibody | Human Olig2 Antibody | Olig2 Antibody
Small molecules enable neurogenin 2 to efficiently convert human fibroblasts into cholinergic neurons<...
ORBi: Browsing ORBi
Differential regulation of granulopoiesis by the basic helix-loop-helix transcriptional inhibitors Id1 and Id2. - Radcliffe...
Oral Presentation - ASN Events
Epigenetic Regulation of Nestin Expression During Neurogenic Differentiation of Adipose Tissue Stem Cells.
2 signals -- from within and out of cell -- specify motor neuron differentiation
twist: A Myogenic Switch in Drosophila | Science
Phospho-regulation of ATOH1 Is Required for Plasticity of Secretory Progenitors and Tissue Regeneration. - MRC Weatherall...
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ID2 (Inhibitor Of DNA Binding 2, Dominant Negative Helix-Loop-Helix Protein)
Anti-NSCL1 (HEN1; Helix-loop-helix protein 1) Polyclonal Antibody, Unconjugated from CHEMICON
OriGene - Heyl (NM 013905) cDNA Clone
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jira] [Updated] (MATH-746) Things to do before releasing 3.0
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ID2 - ويكيبيديا
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A roughness-dependent model -- CFD-Wiki, the free CFD reference
Clayton, GA SAT Math Tutor
NPAS1
... is a basic helix-loop-helix transcription factor. NPAS3 Zhou YD, Barnard M, Tian H, Li X, Ring HZ, Francke U, Shelton J, ... "Characterization of a subset of the basic helix-loop-helix-PAS superfamily that interacts with components of the dioxin ...
HLF (gene)
"Entrez Gene: HLF hepatic leukemia factor". LeBrun DP (May 2003). "E2A basic helix-loop-helix transcription factors in human ... This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The ... "Enhanced binding of HLF/DBP heterodimers represents one mechanism of PAR protein transactivation of the factor VIII and factor ... Hunger SP, Li S, Fall MZ, Naumovski L, Cleary ML (June 1996). "The proto-oncogene HLF and the related basic leucine zipper ...
Neurogenins
Neurogenin 1 (Ngn1) is a Class-A basic-helix-loop-helix (bHLH) transcription factor that acts as a regulator for neuronal ... Li HJ, Ray SK, Singh NK, Johnston B, Leiter AB (Oct 2011). "Basic helix-loop-helix transcription factors and enteroendocrine ... The promotion of GFAP transcription induced glial differentiation. Neurogenin 2 (Ngn2) is a bHLH transcription factor involved ... Another transcription factor that may be a downstream target of Ngn3 is Nkx2.2 because it is often coexpressed with it. Studies ...
ANKS1B
LeBrun DP (2004). "E2A basic helix-loop-helix transcription factors in human leukemia". Front. Biosci. 8 (1-3): s206-22. doi: ... "Regulation of amyloid precursor protein expression and secretion via activation of ERK1/2 by hepatocyte growth factor in HEK293 ...
MYF6
Myogenic factors are basic helix-loop-helix (bHLH) transcription factors. MYF6 is a gene that encodes a protein involved in the ... "A novel type of calmodulin interaction in the inhibition of basic helix-loop-helix transcription factors". Biochemistry. 39 (15 ... "Differential interactions of Id proteins with basic-helix-loop-helix transcription factors". The Journal of Biological ... The portion of the protein integral to myogenesis regulation requires the basic helix-loop-helix (bHLH) domain that is ...
MYF5
... belongs to a family of proteins known as myogenic regulatory factors (MRFs). These basic helix loop helix transcription ... "Differential interactions of Id proteins with basic-helix-loop-helix transcription factors". The Journal of Biological ... MRF family members include Myf5, MyoD (Myf3), myogenin, and MRF4 (Myf6). This transcription factor is the earliest of all MRFs ... As for its clinical significance, the aberration of this transcription factor provides part of the mechanism for how hypoxia ( ...
Cyclin D1
Ratineau C, Petry MW, Mutoh H, Leiter AB (March 2002). "Cyclin D1 represses the basic helix-loop-helix transcription factor, ... Zhang T, Liu WD, Saunee NA, Breslin MB, Lan MS (February 2009). "Zinc finger transcription factor INSM1 interrupts cyclin D1 ... Cyclin D1-CDK4 also associates with several transcription factors and transcriptional co-regulators. Independent of CDK, cyclin ... allowing E2F transcription factors to transcribe genes required for entry into the S phase. Inactive pRb allows cell cycle ...
LOC642658
Basic helix-loop-helix transcription factor scleraxis is a protein that in humans is encoded by the SCXB gene. GRCh38: Ensembl ... "Entrez Gene: LOC642658 similar to Basic helix-loop-helix transcription factor scleraxis". CS1 maint: discouraged parameter ( ...
NEUROD1
It is a member of the NeuroD family of basic helix-loop-helix (bHLH) transcription factors. The protein forms heterodimers with ... Ratineau C, Petry MW, Mutoh H, Leiter AB (March 2002). "Cyclin D1 represses the basic helix-loop-helix transcription factor, ... Ratineau C, Petry MW, Mutoh H, Leiter AB (March 2002). "Cyclin D1 represses the basic helix-loop-helix transcription factor, ... "A novel type of calmodulin interaction in the inhibition of basic helix-loop-helix transcription factors". Biochemistry. 39 (15 ...
MyoD
... basic helix loop helix) transcription factors act sequentially in myogenic differentiation. Vertebrate MRF family members ... "Differential interactions of Id proteins with basic-helix-loop-helix transcription factors". J. Biol. Chem. 272 (32): 19785-93 ... now referred to as basic helix loop helix) for dimerization and a basic site upstream of this bHLH region facilitated DNA ... Finkel T, Duc J, Fearon ER, Dang CV, Tomaselli GF (January 1993). "Detection and modulation in vivo of helix-loop-helix protein ...
TAL1
The protein encoded by TAL1 is a basic helix-loop-helix transcription factor. TAL1 has been shown to interact with: CBFA2T3, ... Green AR, Begley CG (1993). "SCL and related hemopoietic helix-loop-helix transcription factors". Int. J. Cell Cloning. 10 (5 ... "The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells". Proc. Natl. ... "The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells". Proc. Natl. ...
SIM2
Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors". The Journal of Biological Chemistry. ... Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors". The Journal of Biological Chemistry. ... Ooe N, Saito K, Mikami N, Nakatuka I, Kaneko H (Jan 2004). "Identification of a novel basic helix-loop-helix-PAS factor, NXF, ... Ooe N, Saito K, Mikami N, Nakatuka I, Kaneko H (Jan 2004). "Identification of a novel basic helix-loop-helix-PAS factor, NXF, ...
Aryl hydrocarbon receptor nuclear translocator
Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors". J. Biol. Chem. 277 (12): 10236-43. doi: ... Ooe N, Saito K, Mikami N, Nakatuka I, Kaneko H (January 2004). "Identification of a novel basic helix-loop-helix-PAS factor, ... Wang GL, Jiang BH, Rue EA, Semenza GL (1995). "Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated ... "Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin ...
Endothelial stem cell
This gene encodes the basic helix-loop-helix structure and functions as a transcription factor. Embryos lacking Tal1 fail to ... In addition, basic fibroblast growth factor FGF-2 is also involved in promoting angioblasts from the mesoderm. After ... Prox-1is a homeobox transcription factor found in lymphatic ECs (LECs). For example, specific mRNAs such as VEGFR-3 and p57Kip2 ... "Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor". EMBO Journal. ...
HES1
This protein belongs to the basic helix-loop-helix (bHLH) family of transcription factors. It is a transcriptional repressor of ... Jögi A, Persson P, Grynfeld A, Påhlman S, Axelson H (2002). "Modulation of basic helix-loop-helix transcription complex ... a basic helix-loop-helix repressor of neuronal differentiation". Genes Dev. 11 (23): 3168-81. doi:10.1101/gad.11.23.3168. PMC ... and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-1. Negative autoregulation through the ...
DTX1
... it may play a role in basic helix-loop-helix transcription factor activity. DTX1 has been shown to interact with EP300. GRCh38 ...
ATOH1
2007). "Basic helix-loop-helix transcription factor profiling of lung tumors shows aberrant expression of the proneural gene ... This protein belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent ... "The intestine-specific homeobox gene Cdx2 induces expression of the basic helix-loop-helix transcription factor Math1". ... Leow CC, Polakis P, Gao WQ (November 2005). "A role for Hath1, a bHLH transcription factor, in colon adenocarcinoma". Annals of ...
Sterol regulatory element-binding protein
SREBPs belong to the basic-helix-loop-helix leucine zipper class of transcription factors. Unactivated SREBPs are attached to ... Gasic GP (Apr 1994). "Basic-helix-loop-helix transcription factor and sterol sensor in a single membrane-bound molecule". Cell ... a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene". Cell ... SREBPs have a structure similar to E-box-binding helix-loop-helix (HLH) proteins. However, in contrast to E-box-binding HLH ...
TAL2
... is a member of the basic helix-loop-helix family of transcription factors. Tumor-specific alterations of the TAL2 gene ... Baer R (December 1993). "TAL1, TAL2 and LYL1: a family of basic helix-loop-helix proteins implicated in T cell acute leukaemia ... 1992). "TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia". Proc. Natl. Acad ... a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia". Proc. Natl. Acad. Sci. U.S.A. ...
Ethylin Wang Jabs
... a basic helix-loop-helix transcription factor, in Saethre-Chotzen syndrome". Nature Genetics. 15 (1): 36-41. doi:10.1038/ng0197 ... She discovered that similar mutations in the same gene, fibroblast growth factor receptor 2 or FGFR2, cause both Jackson-Weiss ... "Jackson-Weiss and Crouzon syndromes are allelic with mutations in fibroblast growth factor receptor 2". Nature Genetics. 8 (3 ...
MYCL
... 1 is a bHLH (basic helix-loop-helix) transcription factor implicated in lung cancer. MYCL1 has been shown to interact with ... Blackwood EM, Eisenman RN (Mar 1991). "Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding ... Lüscher B (2001). "Function and regulation of the transcription factors of the Myc/Max/Mad network". Gene. 277 (1-2): 1-14. doi ... a useful prognostic factor of poor outcomes in colorectal cancer". Clin. Cancer Res. 10 (5): 1758-1763. doi:10.1158/1078-0432. ...
HAND2
The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is ... "The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex ... Dai YS, Cserjesi P (April 2002). "The basic helix-loop-helix factor, HAND2, functions as a transcriptional activator by binding ... transcription factor binding. • activating transcription factor binding. • E-box binding. • protein binding. • protein ...
TCF21 (gene)
TCF21 encodes a transcription factor of the basic helix-loop-helix (bHLH) family, which manages cell-fate specification, ... Lu J, Chang P, Richardson JA, Gan L, Weiler H, Olson EN (August 2000). "The basic helix-loop-helix transcription factor ... Funato N, Ohyama K, Kuroda T, Nakamura M (February 2003). "Basic helix-loop-helix transcription factor epicardin/capsulin/Pod-1 ... basic helix-loop-helix) family of transcription factors. This protein is predicted to span 179 amino acid residues and contains ...
NEUROD2
"Interaction of PKN with a neuron-specific basic helix-loop-helix transcription factor, NDRF/NeuroD2". Brain Research. Molecular ... "Interaction of PKN with a neuron-specific basic helix-loop-helix transcription factor, NDRF/NeuroD2". Brain Research. Molecular ... This gene encodes a member of the neuroD family of neurogenic basic helix-loop-helix (bHLH) proteins. Expression of this gene ... a NeuroD family basic helix-loop-helix protein". Brain Research. Molecular Brain Research. 60 (1): 107-14. doi:10.1016/S0169- ...
Mef2
"Combinatorial control of muscle development by basic helix-loop-helix and MADS-box transcription factors". Proc Natl Acad Sci ... Mef2c upregulates the expression of the homeodomain transcription factors DLX5 and DLX6, two transcription factors that are ... MEF2, Myocyte Enhancer Factor 2, is a transcription factor with four specific numbers such as MEF2A, B, C, and D. Each MEF2 ... "Myocyte Enhancer Factor 2 Transcription Factors in Heart Development and Disease." Heart Development and Regeneration, 2010, pp ...
OLIG1
"Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors". Neuron. 25 ... McLellan AS, Langlands K, Kealey T (Dec 2002). "Exhaustive identification of human class II basic helix-loop-helix proteins by ... McLellan AS, Langlands K, Kealey T (Dec 2002). "Exhaustive identification of human class II basic helix-loop-helix proteins by ... "Dynamic expression of basic helix-loop-helix Olig family members: implication of Olig2 in neuron and oligodendrocyte ...
Protein kinase N1
"Interaction of PKN with a neuron-specific basic helix-loop-helix transcription factor, NDRF/NeuroD2". Brain Res. Mol. Brain Res ... which is a potential transcription factor". Exp. Cell Res. 241 (2): 363-72. doi:10.1006/excr.1998.4060. PMID 9637778. Takahashi ...
Trichome
The development pathway is regulated by three transcription factors: R2R3 MYB, basic helix-loop-helix, and WD40 repeat. The ... Both processes involve a core of related transcription factors that control the initiation and development of the epidermal ... Activation of genes that encode specific protein transcription factors (named GLABRA1 (GL1), GLABRA3 (GL3) and TRANSPARENT ... The most basic terms used are glabrous-lacking hairs- and pubescent-having hairs. Details are provided by: *glabrous, glabrate ...
Myc
... family of transcription factors contain a bHLH (basic helix-loop-helix) structural and LZ (leucine zipper) motives. Through ... repressing transcription factor binding. • RNA polymerase II transcription factor activity, sequence-specific DNA binding. • ... Blackwood EM, Eisenman RN (March 1991). "Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding ... Blackwood EM, Eisenman RN (March 1991). "Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding ...
ASCL2
This gene is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by ... is a maternally expressed imprinted gene that codes is a part of the basic helix-loop-helix (BHLH) transcription factor family ... "A novel type of calmodulin interaction in the inhibition of basic helix-loop-helix transcription factors". Biochemistry. 39 (15 ... possible role of placenta-specific basic helix-loop-helix transcription factor, human achaete-scute homologue-2". Journal of ...
Basic helix-loop-helix leucine zipper transcription factors - Wikipedia
Basic helix-loop-helix leucine zipper transcription factors are, as their name indicates, transcription factors containing both ... Basic+helix-loop-helix+leucine+zipper+transcription+factors at the US National Library of Medicine Medical Subject Headings ( ... Basic helix-loop-helix and leucine zipper motifs. Examples include Microphthalmia-associated transcription factor and Sterol ...
A Classification of Basic Helix-Loop-Helix Transcription Factors of Soybean
Basic helix-loop-helix transcription factors DEC1 and DEC2 regula...: Ingenta Connect
Basic Helix-Loop-Helix Transcription Factors | Molecular and Cellular Biology
FIGLA, a Basic Helix-Loop-Helix Transcription Factor, Balances Sexually Dimorphic Gene Expression in Postnatal Oocytes Wei Hu, ... Hepatocyte Nuclear Factor 4α Coordinates a Transcription Factor Network Regulating Hepatic Fatty Acid Metabolism Celia Pilar ... The TAL1/SCL Transcription Factor Regulates Cell Cycle Progression and Proliferation in Differentiating Murine Bone Marrow ... Hypoxia-Inducible Factor 2 Regulates Hepatic Lipid Metabolism Erinn B. Rankin, Jennifer Rha, Mary A. Selak, Travis L. Unger, ...
Identification of a basic helix-loop-helix transcription factor expressed in mammary gland alveolar cells and required for...
A key family of transcription factors used in mammary gland development is the helix-loop-helix/basic helix-loop-helix (HLH/ ... Identification of a basic helix-loop-helix transcription factor expressed in mammary gland alveolar cells and required for ... Basic Helix-Loop-Helix Transcription Factors/deficiency. *Basic Helix-Loop-Helix Transcription Factors/genetics ... In this study, we identify Mist1 as a tissue-restricted Class II bHLH transcription factor expressed in lactating mammary ...
The basic helix-loop-helix transcription factor neuroD is expressed in the rod lineage of the teleost retina. - PubMed - NCBI
The basic helix-loop-helix transcription factor neuroD is expressed in the rod lineage of the teleost retina.. Hitchcock P1, ... we sought to characterize the cellular expression of the basic helix-loop-helix (bHLH) transcription factor neuroD in the ... Basic Helix-Loop-Helix Transcription Factors. *Histamine Agonists. *Nerve Tissue Proteins. *Proliferating Cell Nuclear Antigen ...
The Basic Helix-Loop-Helix Transcription Factor NEUROG3 Is Required for Development of the Human Endocrine Pancreas | Diabetes
The Basic Helix-Loop-Helix Transcription Factor NEUROG3 Is Required for Development of the Human Endocrine Pancreas. ... The Basic Helix-Loop-Helix Transcription Factor NEUROG3 Is Required for Development of the Human Endocrine Pancreas ... The Basic Helix-Loop-Helix Transcription Factor NEUROG3 Is Required for Development of the Human Endocrine Pancreas ... The Basic Helix-Loop-Helix Transcription Factor NEUROG3 Is Required for Development of the Human Endocrine Pancreas ...
The Arabidopsis Basic/Helix-Loop-Helix Transcription Factor Family | Plant Cell
The Arabidopsis Basic/Helix-Loop-Helix Transcription Factor Family Message Subject (Your Name) has sent you a message from ... The Arabidopsis Basic/Helix-Loop-Helix Transcription Factor Family. Gabriela Toledo-Ortiz, Enamul Huq, Peter H. Quail ... The basic/helix-loop-helix (bHLH) proteins are a superfamily of transcription factors that bind as dimers to specific DNA ... The basic/helix-loop-helix (bHLH) proteins are a superfamily of transcription factors that have been well characterized in ...
HIF1A - Hypoxia inducible factor 1, alpha subunit (Basic helix-loop-helix transcription factor) - Bos taurus (Bovine) - HIF1A...
Hypoxia inducible factor 1, alpha subunit (Basic helix-loop-helix transcription factor)Imported. ,p>Information which has been ... tr,A0JND0,A0JND0_BOVIN Hypoxia inducible factor 1, alpha subunit (Basic helix-loop-helix transcription factor) OS=Bos taurus GN ... Hypoxia inducible factor 1, alpha subunit (Basic helix-loop-helix transcription factor). ... transcription factor activity, RNA polymerase II transcription factor binding Source: Ensembl. *transcription factor binding ...
New members of the Drosophila Myc transcription factor subfamily revealed by a genome-wide examination for basic helix-loop...
The basic helix-loop-helix (bHLH) proteins represent an evolutionary conserved class of transcription factors that are known to ... New members of the Drosophila Myc transcription factor subfamily revealed by a genome-wide examination for basic helix-loop- ... These new genes belong to various subfamilies of bHLH transcription factors, such as the Daughterless, Hairy-Enhancer of split ... helix genes.. Peyrefitte S., Kahn D., Haenlin M.. ...
Basic Helix-Loop-Helix Transcription Factor NEUROG1 and Schizophrenia: Effects on Illness Susceptibility, MRI Brain Morphometry...
... including the basic helix-loop-helix (bHLH) family, regulate numerous genes and play vital roles in controlling gene expression ... Consequently, transcription factor mutations can lead to phenotypic pleiotropy, and may be a candidate mechanism underlying the ... Transcription factors, including the basic helix-loop-helix (bHLH) family, regulate numerous genes and play vital roles in ... Basic Helix-Loop-Helix Transcription Factor NEUROG1 and Schizophrenia: Effects on Illness Susceptibility, MRI Brain Morphometry ...
Myc Proto Oncogene Protein Transcription Factor p64 or Class E Basic Helix Loop Helix Protein 39 or MYC Pipeline Review, H1...
Myc Proto Oncogene Protein Transcription Factor p64 or Class E Basic Helix Loop Helix Protein 39 or MYC Pipeline Review, H1 ... Inducible Factor 1 Alpha ARNT Interacting Protein or Basic Helix Loop Helix PAS Protein MOP1 or Class E Basic Helix Loop Helix ... Inducible Factor 1 Alpha ARNT Interacting Protein or Basic Helix Loop Helix PAS Protein MOP1 or Class E Basic Helix Loop Helix ... Protein Transcription Factor p64 or Class E Basic Helix Loop Helix Protein 39 or MYC Pipeline Review, H1 2018. ...
Myc Proto Oncogene Protein (Transcription Factor p64 or Class E Basic Helix Loop Helix Protein 39 or MYC) - Pip Review, H2 2018
Transcription Factor p64 or Class E Basic Helix Loop Helix Protein 39 or MYC) - Pip Review, H2 2018Myc Proto Oncogene Protein ( ... Myc Proto Oncogene Protein (Transcription Factor p64 or Class E Basic Helix Loop Helix Protein 39 or MYC) - Myc (c-Myc) protein ... It also reviews key players involved in Myc Proto Oncogene Protein (Transcription Factor p64 or Class E Basic Helix Loop Helix ... The report reviews Myc Proto Oncogene Protein (Transcription Factor p64 or Class E Basic Helix Loop Helix Protein 39 or MYC) ...
RePub, Erasmus University Repository:
The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL...
The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia. ... The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia. Nature ... Here, we identify the circadian clock transcription factor SHARP1 as a novel oncogenic target in MLL-AF6 AML, which has the ...
Myc Proto Oncogene Protein (Transcription Factor p64 or Class E Basic Helix Loop Helix Protein 39 or MYC) - Pip Review, H2 2018...
Transcription Factor p64 or Class E Basic Helix Loop Helix Protein 39 or MYC) - Pip Review, H2 2018 Size and Share Published in ... Myc Proto Oncogene Protein (Transcription Factor p64 or Class E Basic Helix Loop Helix Protein 39 or MYC) - Pip Review, H2 2018 ... Myc Proto Oncogene Protein (Transcription Factor p64 or Class E Basic Helix Loop Helix Protein 39 or MYC) - Myc (c-Myc) protein ... It also reviews key players involved in Myc Proto Oncogene Protein (Transcription Factor p64 or Class E Basic Helix Loop Helix ...
Human T-Cell Leukemia Virus Type 1 Tax Protein Inhibits the Expression of the Basic Helix-Loop-Helix Transcription Factor MyoD...
Human T-Cell Leukemia Virus Type 1 Tax Protein Inhibits the Expression of the Basic Helix-Loop-Helix Transcription Factor MyoD ... Tax was found to target the muscle-specific basic helix-loop-helix transcription factor MyoD. The Tax-induced increase in ... In these cells, which displayed unchanged levels of the ubiquitous basic helix-loop-helix E2A factors and Id proteins, ... A potential mechanism for Tax-mediated repression of the transcriptional activity of basic helix-loop-helix factors. J. Biol. ...
Myc Proto Oncogene Protein (Transcription Factor p64 or Class E Basic Helix Loop Helix Protein 39 or MYC) - Pipeline Review, H2...
Myc Proto Oncogene Protein (Transcription Factor p64 or Class E... ... 38 Pages Report] Check for Discount on Myc Proto Oncogene Protein (Transcription Factor p64 or Class E Basic Helix Loop Helix ... Myc Proto Oncogene Protein (Transcription Factor p64 or Class E Basic Helix Loop Helix Protein 39 or MYC) - Myc (c-Myc) protein ... Myc Proto Oncogene Protein (Transcription Factor p64 or Class E Basic Helix Loop Helix Protein 39 or MYC) - Drug Profiles. BGA- ...
Expression of the Microphthalmia-associated Basic Helix-Loop-Helix Leucine Zipper Transcription Factor Miin Avian Neuroretina...
The mi gene encodes a basic helix-loop-helix leucine zipper transcription factor (Mi) with tissue-restricted expression. To ... Aksan I., Goding C. R. Targeting the microphthalmia basic helix-loop-helix-leucine zipper transcription factor to a subset of E ... Expression of the Microphthalmia-associated Basic Helix-Loop-Helix Leucine Zipper Transcription Factor Miin Avian Neuroretina ... crucial dependence on the Mitf basic-helix-loop-helix-zipper transcription factor. Development (Camb.), 124: 2377-2386, 1997.. ...
Challenges in Targeting a Basic Helix-Loop-Helix Transcription Factor with Hydrocarbon-Stapled Peptides
Basic helix-loop-helix (bHLH) transcription factors play critical roles in organism development and disease by regulating cell ... Challenges in Targeting a Basic Helix-Loop-Helix Transcription Factor with Hydrocarbon-Stapled Peptides. DSpace/Manakin ... These data highlight potential pitfalls in peptide-based targeting of bHLH transcription factors given the liabilities of their ... Thus, α-helical decoys have been proposed as potential targeted therapies for pathologic bHLH ... read more transcription. Here ...
Genome-wide analysis of basic/helix-loop-helix transcription factor family in rice and Arabidopsis<...
basic helix-loop-helix transcription factors Agriculture & Biology * Basic Helix-Loop-Helix Transcription Factors Medicine & ... N2 - The basic/helix-loop-helix (bHLH) transcription factors and their homologs form a large family in plant and animal genomes ... AB - The basic/helix-loop-helix (bHLH) transcription factors and their homologs form a large family in plant and animal genomes ... The basic/helix-loop-helix (bHLH) transcription factors and their homologs form a large family in plant and animal genomes. ...
Gentaur Molecular :Prosci \ Transcription factors containing a basic helix-loop-helix (bHLH) motif regulate expression of...
Transcription factors containing a basic helix-loop-helix (bHLH) motif regulate expression of tissue-specific genes in a number ... Product name : Transcription factors containing a basic helix-loop-helix (bHLH) motif regulate expression of tissue-specific ... 25-056 Transcription factors containing a basic helix-loop-helix (bHLH) motif regulate expression of tissue-specific genes in a ... Related products : Transcription factors containing a basic helix-loop-helix (bHLH) motif regulate expression of tissue- ...
The basic helix-loop-helix transcription factor family in plants: a genome-wide study of protein structure and functional...
The Arabidopsis basic/helix-loop-helix transcription factor family.. Toledo-Ortiz G, Huq E, Quail PH., Plant Cell 15(8), 2003 ... A classification of basic helix-loop-helix transcription factors of soybean.. Hudson KA, Hudson ME., Int J Genomics 2015(), ... Basic helix-loop-helix transcription factors and epidermal cell fate determination in Arabidopsis.. Zhao H, Li X, Ma L., Plant ... Update on the basic helix-loop-helix transcription factor gene family in Arabidopsis thaliana.. Bailey PC, Martin C, Toledo- ...
"The myogenic basic helix-loop-helix family of transcription factors sh" by Kanaklata Roy, Ivana L. de la Serna et al.
The myogenic basic helix-loop-helix family of transcription factors, MyoD, Myf5, myogenin, and MRF4, can each activate the ... The myogenic basic helix-loop-helix family of transcription factors, MyoD, Myf5, myogenin, and MRF4, can each activate the ... The myogenic basic helix-loop-helix family of transcription factors shows similar requirements for SWI/SNF chromatin remodeling ... "The myogenic basic helix-loop-helix family of transcription factors shows similar requirements for SWI/SNF chromatin remodeling ...
Synthetic Biology Center | Basic Helix-Loop-Helix Transcription Factors
Optical control of mammalian endogenous transcription and epigenetic states. August 22, 2013. /0 Comments/in Publications /by ... Optical control of mammalian endogenous transcription and epigenetic states. Nature. 500(7463):472-6. Google Scholar PubMed. ... 26Optical control of mammalian endogenous transcription and epigenetic states.. ...
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors | Colorado PROFILES
Basic Helix-Loop-Helix Transcription Factors [D12.776.260.103]. *Basic Helix-Loop-Helix Leucine Zipper Transcription Factors [ ... Basic Helix-Loop-Helix Transcription Factors [D12.776.930.125]. *Basic Helix-Loop-Helix Leucine Zipper Transcription Factors [ ... Basic Helix-Loop-Helix Leucine Zipper Transcription Factors*Basic Helix-Loop-Helix Leucine Zipper Transcription Factors ... Basic-Leucine Zipper Transcription Factors [D12.776.260.108]. *Basic Helix-Loop-Helix Leucine Zipper Transcription Factors [ ...
Temat: 'Basic Helix-Loop-Helix Transcription Factors' - OpacWWW - Prolib Integro
Basic. Helix. -. Loop. -. Helix. Transcription. Factors. */genetics Basic. Helix. -. Loop. -. Helix. Transcription. Factors. */ ... Basic. Helix. -. Loop. -. Helix. Transcription. Factors. */blood Basic. Helix. -. Loop. -. Helix. Transcription. Factors. */ ... Basic. Helix. -. Loop. -. Helix. Transcription. Factors. /*chemistry Basic. Helix. -. Loop. -. Helix. Transcription. Factors. / ... Basic. Helix. -. Loop. -. Helix. Transcription. Factors. /agonists ; Basic. Helix. -. Loop. -. Helix. Transcription. Factors. / ...
Examination of mammalian basic helix-loop-helix transcription factors using a yeast one-hybrid system
Although a great deal is understood about how bHLH factors activate gene transcription via E-box DNA consensus sequences, ... transcription factors play diverse roles in controlling many developmental events. ... studies of bHLH factor function in higher eukaryotes often have b … ... Examination of mammalian basic helix-loop-helix transcription factors using a yeast one-hybrid system DNA Cell Biol. 1996 Jan; ...
nature.com search
Genome-wide DNA-binding specificity of PIL5, a Arabidopsis basic helix-loop-helix (bHLH) transcription factor<...
... a Arabidopsis basic helix-loop-helix (bHLH) transcription factor. Together they form a unique fingerprint. * Transcription ... a Arabidopsis basic helix-loop-helix (bHLH) transcription factor",. abstract = "PIL5 is a member of the bHLH transcription ... Genome-wide DNA-binding specificity of PIL5, a Arabidopsis basic helix-loop-helix (bHLH) transcription factor. / Kang, Hyojin; ... Genome-wide DNA-binding specificity of PIL5, a Arabidopsis basic helix-loop-helix (bHLH) transcription factor. Proceedings - ...
ProteinsGenesMammalianRegulationMotifsDominant negative helix-loop-Mainly of hydrophobic residuesTranscriptionalSuperfamilyAbstractRegulateHomologResiduesEncodesMotifInhibitsFamilyDevelopmentalHypoxia-InduciEukaryoticBHLH factorLeucineMolecularSharp1Gene transcriptionCooperativelySignal TransductionActivatorIntracellularBMAL1SoybeanSequenceNeuroDNeuronalSubfamilyExpressionHomodimerizationAtf4NuclearMice
Proteins15
- The basic/helix-loop-helix (bHLH) proteins are a superfamily of transcription factors that bind as dimers to specific DNA target sites and that have been well characterized in nonplant eukaryotes as important regulatory components in diverse biological processes. (plantcell.org)
- Together with the established propensity of bHLH factors to engage in varying degrees of homodimerization and heterodimerization, these observations suggest that the Arabidopsis bHLH proteins have the potential to participate in an extensive set of combinatorial interactions, endowing them with the capacity to be involved in the regulation of a multiplicity of transcriptional programs. (plantcell.org)
- The basic helix-loop-helix (bHLH) proteins represent an evolutionary conserved class of transcription factors that are known to play important roles in cell determination and differentiation during animal embryonic development. (uniprot.org)
- Members of the MyoD family of muscle-specific basic helix-loop-helix (bHLH) proteins function within a genetic pathway to control skeletal muscle development. (elsevier.com)
- Members of the myocyte enhancer binding factor 2 (MEF2) family of MADS-box proteins are expressed at high levels in muscle and neural cells and at lower levels in several other cell types. (elsevier.com)
- MEF2 factors are unable to activate muscle gene expression alone, but they potentiate the transcriptional activity of myogenic bHLH proteins. (elsevier.com)
- Biochemical and genetic evidence suggests that MEF2 factors are the coregulators for myogenic bHLH proteins. (elsevier.com)
- In myogenesis, E-proteins are proposed to function as obligate heterodimer partners for members of the MyoD family of muscle-specific bHLH transcription factors. (dissertations.se)
- Transcription factors of the basic Helix-loop-helix (bHLH) family of proteins are important regulators of cellular processes such as proliferation and differentiation. (dissertations.se)
- The transcription factors neuronal helix-loop-helix protein (NEX)/mammalian atonal homolog 2 (Math-2), BETA2/neuronal determination factor (NeuroD), and NeuroD-related factor (NDRF)/NeuroD2 comprise a family of Drosophila atonal-related basic helix-loop-helix (bHLH) proteins with highly overlapping expression in the developing forebrain. (jneurosci.org)
- 5 6 These latter factors, encoded by the E2A gene, belong to the family of basic helix loop helix (bHLH) proteins. (bloodjournal.org)
- 8 9 The helix-loop-helix domain, mainly consisting of hydrophobic residues, permits homodimerization or heterodimerization of these proteins. (bloodjournal.org)
- Inhibitors of DNA binding (Id) proteins control transcriptional activity of bHLH factors. (bloodjournal.org)
- 12 13 Id proteins can heterodimerize with bHLH factors, but lack a basic DNA binding domain, therefore blocking transcriptional activity of bHLH factors. (bloodjournal.org)
- 2000). bHLH proteins form homo- or heterodimers with other bHLH family members and, as dimers, bind DNA through the bHLH domain at cis regulatory motifs, termed E-box (CANNTG), leading to either activation or inhibition of transcription (Murre et al. (atlasgeneticsoncology.org)
Genes21
- Using a set of criteria derived from a previously defined consensus motif, we identified 147 bHLH protein-encoding genes, making this one of the largest transcription factor families in Arabidopsis. (plantcell.org)
- New members of the Drosophila Myc transcription factor subfamily revealed by a genome-wide examination for basic helix-loop-helix genes. (uniprot.org)
- These new genes belong to various subfamilies of bHLH transcription factors, such as the Daughterless, Hairy-Enhancer of split, bHLH-PAS or bHLHZip subfamilies. (uniprot.org)
- Transcription factors, including the basic helix-loop-helix (bHLH) family, regulate numerous genes and play vital roles in controlling gene expression. (nih.gov)
- Myc protein is a transcription factor that activates expression of many genes through binding enhancer box sequences and recruiting histone acetyltransferases. (bioportfolio.com)
- By binding Miz1 transcription factor and displacing the p300 coactivator, it inhibits expression of Miz1 target genes. (bioportfolio.com)
- Gentaur Molecular :Prosci \ Transcription factors containing a basic helix-loop-helix (bHLH) motif regulate expression of tissue-specific genes in a number of mammalian and insect systems. (antibody-antibodies.com)
- The AtbHLH genes constitute one of the largest families of transcription factors in A. thaliana with significantly more members than are found in most animal species and about an equivalent number to those in vertebrates. (uni-bielefeld.de)
- In this study, we report that promoters of the genes encoding the enzymes involved in the specific terpenoid pathway of one of these species can be transactivated by the orthologous bHLH factor from the other species through recognition of the same cis-regulatory elements. (lu.se)
- This protein is a transcription factor, which means that it attaches (binds) to specific regions of DNA and controls the activity of particular genes. (medlineplus.gov)
- The MESP2 gene provides instructions for making a transcription factor, which is a protein that attaches (binds) to specific regions of DNA and helps control the activity of particular genes. (medlineplus.gov)
- We characterized orthologs of fruit-associated MADS-domain transcription factors and of the Arabidopsis dehiscence-related genes INDEHISCENT (IND)/HECATE 3 (HEC3), REPLUMLESS (RPL) and SPATULA (SPT)/ALCATRAZ (ALC) in E. pusilla , and found that the key players of the eudicot fruit regulatory network appear well-conserved in monocots. (frontiersin.org)
- The multi-output incoherent feedforward loop constituted by the transcriptional regulators LasR and RsaL confers robustness to a subset of quorum sensing genes in Pseudomonas aeruginosa. (bireme.br)
- Moreover, a bioinformatics analysis predicts that many of the dysregulated genes are regulated by common transcription factors, one of which, Ascl1 , was confirmed to be directly controlled by Ca 2+ influx in β-cells. (diabetesjournals.org)
- which includes neuronal helix-loop-helix protein (NEX)/mammalian atonal homolog-2 (Math-2), BETA2/neuronal determination factor (NeuroD), and NeuroD-related factor (NDRF)/NeuroD2, is less clear, however, because these genes are expressed throughout neuronal development and largely by committed cells outside the ventricular zone. (jneurosci.org)
- A motif of basic residues mediates binding to a consensus E-box (CANNTG) sequence present in promoters or enhancers of target genes. (bloodjournal.org)
- The genes up-regulated by this transcription factor during embryogenesis have not been identified. (medscape.com)
- The data revealed that hundreds of upregulated and downregulated genes, including various transcription factors (TFs), are involved in flower senescence progress. (usda.gov)
- In petunia flowers, expression profiles of the ethylene-responsive element-binding factor (ERF) family genes were studied in detail. (usda.gov)
- We identified a cluster of genes upregulated during development and senescence of petunia flowers, including several transcription factors. (usda.gov)
- 1988 ) Expression patterns of the homeobox-containing genes En-1 and En-2 and the proto-oncogene int-1 diverge during mouse development. (biologists.org)
Mammalian6
- Because of its function in the developing mammalian retina and persistently mitotic adult tissues, we sought to characterize the cellular expression of the basic helix-loop-helix (bHLH) transcription factor neuroD in the persistently neurogenic retina of adult teleosts. (nih.gov)
- Optical control of mammalian endogenous transcription and epigenetic states. (mit.edu)
- wp-content/uploads/2016/03/[email protected] 0 0 syn-admin /wp-content/uploads/2016/03/[email protected] syn-admin 2013-08-22 00:00:20 2016-02-08 15:24:26 Optical control of mammalian endogenous transcription and epigenetic states. (mit.edu)
- Further, eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1), a component of the mammalian target of rapamycin (mTOR) pathway that inhibits protein translation through interaction with EIF4E, is regulated by ATF5 and likely is involved in apoptotic susceptibility through regulation of global translation. (pnas.org)
- Mutation studies in human patients with disorders of sex development and mouse models have revealed factors that are involved in mammalian sex determination. (springer.com)
- 1995 ) A mammalian helix-loop-helix factor structurally related to theproduct of the Drosophila proneural gene atonal is a positive transcriptional regulator expressed in the developing nervous system. (biologists.org)
Regulation15
- Differentiated embryonic chondrocyte gene (DEC) 1 (BHLHE40/Stra13/Sharp2) and DEC2 (BHLHE41/Sharp1) are basic helix-loop-helix (bHLH) transcription factors that are associated with the regulation of apoptosis, cell proliferation and circadian rhythms, as well as malignancy in various cancers. (ingentaconnect.com)
- Neurog3 is required for development of all pancreatic endocrine cell types in mice ( 5 - 7 ) and does this through direct and indirect regulation of downstream targets, including the transcription factors NeuroD1 ( 8 ), Rfx6 ( 9 ), Pax4 ( 10 ), Nkx6.1 ( 11 , 12 ), Arx ( 13 ), and others. (diabetesjournals.org)
- rs2344484-C-allele may affect NEUROG1's role in transcription regulation such that brain morphology and cognitive abilities are altered resulting in increased susceptibility to develop schizophrenia. (nih.gov)
- Regulation of branched-chain amino acid metabolism by hypoxia-inducible factor in glioblastoma. (wroc.pl)
- Thus, this in vivo yeast system provides a novel approach to facilitate functional studies of bHLH factor regulation. (nih.gov)
- Consisting of about 110 amino acids , the domain in winged-helix transcription factors (see Regulation of gene expression ) has four helices and a two-strand beta-sheet . (wikipedia.org)
- Many cancer diseases show a block in differentiation, and aberrant regulation of several bHLH factors have been implicated in the development of different malignancies. (dissertations.se)
- The homeodomain transcription factor and human diabetes gene pancreas/duodenum homeobox protein 1 ( Pdx1 ) regulates β-cell survival and endoplasmic reticulum stress susceptibility, in part through direct regulation of activating transcription factor 4 ( Atf4 ). (pnas.org)
- This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. (cancerindex.org)
- What are the basic methods of regulation of gene expression? (brainscape.com)
- From the same microarray study, a basic helix-loop-helix (bHLH) TF was also found to be highly expressed in flower petals and upregulated during the flower senescence process, suggesting that it may also play a role in the regulation of flower senescence. (usda.gov)
- Regulation of Carotenoid Biosynthesis by Shade Relies on Specific Subsets of Antagonistic Transcription Factors and Cofactors. (lancaster.ac.uk)
- Direct regulation of phytoene synthase gene expression and carotenoid biosynthesis by phytochrome-interacting factors. (lancaster.ac.uk)
- Calcium regulation of myogenesis by differential calmodulin inhibition of basic helix-loop-helix transcription factors. (umu.se)
- MyoD's role as a protein is to aid the regulation of muscle differentiation, the process where basic cell types become more specialised, in this case for muscle tissue. (sciencephoto.com)
Motifs2
- Basic helix-loop-helix leucine zipper transcription factors are, as their name indicates, transcription factors containing both Basic helix-loop-helix and leucine zipper motifs. (wikipedia.org)
- A family of transcription factors that contain regions rich in basic residues, LEUCINE ZIPPER domains, and HELIX-LOOP-HELIX MOTIFS. (ucdenver.edu)
Dominant negative helix-loop-1
- We ligated the gene encoding the dominant negative helix loop helix (HLH) factor Id3 that inhibits many enhancing basic HLH transcription factors into this vector. (bloodjournal.org)
Mainly of hydrophobic residues1
- and is constituted mainly of hydrophobic residues that form two amphipathic α-helices separated by a loop region of variable sequence and length ( Nair and Burley, 2000 ). (plantcell.org)
Transcriptional4
- Transcriptional activity, whether by bHLH homo- or heterodimerization, is dependent on protein-protein and protein-DNA interactions mediated by α-helices. (uu.nl)
- Basic helix-loop-helix (bHLH) transcription factors (TFs) belong to a family of transcriptional regulators present in three eukaryotic kingdoms. (uni-bielefeld.de)
- These findings suggest that Hand factors may act via unique transcriptional mechanisms mediated by bHLH factor partner choice, supporting the notion that alterations of Hand factor stoichiometry may be as deleterious to normal heart morphogenesis as Hand factor loss of function. (elsevier.com)
- Formation of this interface relies on coordinated interactions among transcriptional, epigenetic, and environmental factors. (jci.org)
Superfamily3
- PIL5 is a member of the bHLH transcription factor superfamily and plays crucial roles in phytochrome mediated seed germination process in Arabidopsis. (elsevier.com)
- A large superfamily of transcription factors that contain a region rich in BASIC AMINO ACID residues followed by a LEUCINE ZIPPER domain. (bioportfolio.com)
- Myostatin (or GDF-8), a member of the Transforming Growth Factor-β (TGF-β) superfamily, was first identified in mice by McPherron et al. (biologists.org)
Abstract1
- abstract = "Scleraxis is a basic helix-loop-helix (bHLH) transcription factor shown previously to be expressed in developing chondrogenic cell lineages during embryogenesis. (elsevier.com)
Regulate2
- The bHLH family of transcription factors helps regulate the development of many organs and tissues before birth. (medlineplus.gov)
- The SOX10 gene encodes a member of the high-mobility group-domain Sox family of transcription factors that regulate neural crest development. (medscape.com)
Homolog1
- Numerous studies of intestinal epithelial homeostasis have shown that Atonal homolog 1 (Atoh1), a basic helix-loop-helix (bHLH) transcription factor, is essential for the intestinal goblet cell differentiation. (hindawi.com)
Residues1
- The basic region, located at the N-terminal end of the domain, is involved in DNA binding and consists of ∼15 amino acids with a high number of basic residues. (plantcell.org)
Encodes3
- 5] This gene encodes the basic helix-loop-helix structure and functions as a transcription factor. (wikipedia.org)
- The PAX3 gene encodes a transcription factor with a paired box domain, an octapeptide domain, and a homeobox domain essential for survival of melanocytes during development. (medscape.com)
- The MITF gene encodes a transcription factor containing a basic-helix-loop-helix-leucine zipper. (medscape.com)
Motif3
- Additionally we also found that other attributes such as neighboring motif composition, distance from transcription start site, nucleosome density, DNA methylation and average gene expression were also contributing to PIL5 DNA-binding specificity. (elsevier.com)
- Direct gene activation and RsaL-mediated gene repression, both exerted by LasR on the expression of the output gene lasI, generate a regulatory network motif known as the type 1 incoherent feedforward loop (IFFL-1) that governs 3OC -HSL production. (bireme.br)
- Ubiquitously expressed basic HELIX-LOOP-HELIX MOTIF transcription factors. (curehunter.com)
Inhibits1
- Human T-Cell Leukemia Virus Type 1 Tax Protein Inhibits the Expression of the Basic Helix-Loop-Helix Transcription Factor MyoD in Muscle Cells: Maintenance of Proliferation and Repression of Differentiation -- Riou et al. (aacrjournals.org)
Family16
- A key family of transcription factors used in mammary gland development is the helix-loop-helix/basic helix-loop-helix (HLH/bHLH) protein family. (nih.gov)
- The basic/helix-loop-helix (bHLH) transcription factors and their homologs form a large family in plant and animal genomes. (elsevier.com)
- The basic helix-loop-helix transcription factor family in plants: a genome-wide study of protein structure and functional diversity", Molecular Biology and Evolution , vol. 20, 2003, pp. 735-747. (uni-bielefeld.de)
- The myogenic basic helix-loop-helix family of transcription factors sh" by Kanaklata Roy, Ivana L. de la Serna et al. (umassmed.edu)
- The myogenic basic helix-loop-helix family of transcription factors, MyoD, Myf5, myogenin, and MRF4, can each activate the muscle differentiation program when ectopically expressed in non-muscle cells. (umassmed.edu)
- Although a great deal is understood about how bHLH factors activate gene transcription via E-box DNA consensus sequences, studies of bHLH factor function in higher eukaryotes often have been hindered by the presence of multiple family members. (nih.gov)
- The basic helix-loop-helix (bHLH) transcription factors (TFs) bHLH iridoid synthesis 1 (BIS1) and Triterpene Saponin Activating Regulator (TSAR) 1 and 2, from Catharanthus roseus and Medicago truncatula, respectively, all belong to clade IVa of the bHLH protein family and activate distinct terpenoid pathways, thereby mediating monoterpenoid indole alkaloid (MIA) and triterpene saponin (TS) accumulation, respectively, in these two species. (lu.se)
- Specifically, the TWIST1 protein is part of a large protein family called basic helix-loop-helix (bHLH) transcription factors. (medlineplus.gov)
- In the discovery cohort, we identified a single locus (rs17185536-T) on chromosome 6 near the single-minded family basic helix-loop-helix transcription factor 1 ( SIM1 ) gene that was significantly associated with the risk of erectile dysfunction (odds ratio = 1.26, P = 3.4 × 10 −25 ). (pnas.org)
- Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. (cancerindex.org)
- Transcription factors of the plant-specific apetala2/ethylene response factor (AP2/ERF) family co. (ugent.be)
- This family of HLH factors comprises 4 members (Id1-4) that are highly homologous in their HLH domains. (bloodjournal.org)
- TWIST2 is a transcription factor belonging to the bHLH (basic helix loop helix) family (Li et al. (atlasgeneticsoncology.org)
- Members of this family of transcription factors are involved in the development of specific subsets of neurons in the developing vertebrate nervous system. (biologists.org)
- NPAS1 is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. (fishersci.com)
- On the other hand, SAM-pointed domain-containing Ets transcription factor (SPDEF), a member of the "Ets" transcription factor family, has been reported to trigger the mucous cell metaplasia of pulmonary infectious diseases or athsma. (hindawi.com)
Developmental3
- Basic helix-loop-helix (bHLH) transcription factors play diverse roles in controlling many developmental events. (nih.gov)
- Basic helix-loop-helix (bHLH) transcription factors control developmental decisions for a wide range of embryonic cell types. (elsevier.com)
- Some of these factors control B-cell differentiation at a developmental stage before commitment to the B-cell lineage. (bloodjournal.org)
Hypoxia-Induci2
- Our data establish YB-1 as a critical regulator of hypoxia-inducible factor 1α (HIF1α) expression in sarcoma cells. (cancerindex.org)
- We have cloned and characterized hypoxia-inducible factor 1 (HIF-1), a basic helix-loop-helix transcription factor. (hopkinsmedicine.org)
Eukaryotic2
- Recently, pharmacological modulation of the eukaryotic translation initiation factor-2 (eIF2? (stanford.edu)
- The eukaryotic transcription factor NF-Y (which consists of NF-YA, NF-YB and NF-YC subunits) is involved in many important plant development processes. (biomedcentral.com)
BHLH factor1
- As a first step in developing a simplified in vivo system to examine bHLH factor activities, we examined whether the bHLH muscle regulatory factors MRF4 and MyoD function appropriately in yeast. (nih.gov)
Leucine4
- Expression of the Microphthalmia-associated Basic Helix-Loop-Helix Leucine Zipper Transcription Factor Miin Avian Neuroretina Cells Induces aPigmented Phenotype -- Planque et al. (aacrjournals.org)
- Basic Helix-Loop-Helix Leucine Zipper Transcription Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ucdenver.edu)
- This graph shows the total number of publications written about "Basic Helix-Loop-Helix Leucine Zipper Transcription Factors" by people in this website by year, and whether "Basic Helix-Loop-Helix Leucine Zipper Transcription Factors" was a major or minor topic of these publications. (ucdenver.edu)
- Below are the most recent publications written about "Basic Helix-Loop-Helix Leucine Zipper Transcription Factors" by people in Profiles. (ucdenver.edu)
Molecular2
- These results indicate that BMAL1:CLOCK-induced transcription is negatively regulated by MAPK-mediated phosphorylation of BMAL1 at Thr-534 and suggest a molecular link between circadian-activated MAPK and the clock oscillator. (elsevier.com)
- roles of Twist1 and Twist2 as molecular switches during gene transcription. (springer.com)
Sharp11
- Here, we identify the circadian clock transcription factor SHARP1 as a novel oncogenic target in MLL-AF6 AML, which has the worst prognosis among all subtypes of MLL-rearranged AMLs. (eur.nl)
Gene transcription2
- Their mechanism for controlling gene transcription often involves homodimerization or heterodimerization. (uni-bielefeld.de)
- The HY5-PIF regulatory module coordinates light and temperature control of photosynthetic gene transcription. (lancaster.ac.uk)
Cooperatively1
- APETALA2/ETHYLENE RESPONSE FACTOR and basic helix-loop-helix tobacco transcription factors cooperatively mediate. (ugent.be)
Signal Transduction1
- Twist is activated by a variety of signal transduction pathways, including Akt, signal transducer and activator of transcription 3, mitogen-activated protein kinase, Ras, and Wnt signaling. (springer.com)
Activator1
- Mist1 null (Mist1(KO)) lactating mammary glands were defective in normal lobuloalveolar organization, exhibiting shedding of cells into the alveolus lumen and premature activation of the signal transducer and activator of transcription 3 signaling pathway. (nih.gov)
Intracellular3
- One such factor is chronic elevation in the concentration of intracellular Ca 2+ ([Ca 2+ ] i ), sometimes called excitotoxicity ( 4 ), which may be triggered by sustained β-cell depolarization resulting from chronic stimulation. (diabetesjournals.org)
- The transcription factor cAMP response element-binding protein (CREB) is a rapidly responding intracellular effector of neurotransmitter signaling and growth factor signaling in mature neurons ( Lonze and Ginty, 2002 ). (jneurosci.org)
- However, myocardial CaMKII is excessively activated during disease conditions where it contributes to loss of intracellular Ca2+ homeostasis, membrane hyperexcitability, premature cell death, and hypertrophic and inflammatory transcription. (hopkinsmedicine.org)
BMAL12
- Here we show that MAPK associates with a basic helix-loop-helix-PAS transcription factor BMAL1, a positive regulator for the autoregulatory feedback loop of the circadian oscillator. (elsevier.com)
- Sanada, K , Okano, T & Fukada, Y 2002, ' Mitogen-activated protein kinase phosphorylates and negatively regulates basic helix-loop-helix-PAS transcription factor BMAL1 ', Journal of Biological Chemistry , vol. 277, no. 1, pp. 267-271. (elsevier.com)
Soybean2
- Karen A. Hudson and Matthew E. Hudson, "A Classification of Basic Helix-Loop-Helix Transcription Factors of Soybean," International Journal of Genomics , vol. 2015, Article ID 603182, 10 pages, 2015. (hindawi.com)
- Waterlogging (WL) is a key factor hindering soybean crop productivity worldwide. (biomedcentral.com)
Sequence1
- GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein dimerization activity . (genecards.org)
NeuroD2
- The basic helix-loop-helix transcription factor neuroD is expressed in the rod lineage of the teleost retina. (nih.gov)
- Loss of CREB function in a cell-autonomous manner impairs dendritic development, decreases the expression of the neurogenic transcription factor NeuroD and of the neuronal microtubule-associated protein, doublecortin (DCX), and compromises the survival of newborn neurons. (jneurosci.org)
Neuronal3
- Ngn1 or Neurod3), a bHLH transcription factor encoded on a known schizophrenia linkage region in 5q31.1, induces glutamatergic and suppresses GABAergic neuronal differentiation during embryonic neurodevelopment. (nih.gov)
- bHLH transcription factors function in neuronal development in organisms as diverse as worms and vertebrates. (elsevier.com)
- Portman, DS & Emmons, SW 2000, ' The basic helix-loop-helix transcription factors LIN-32 and HLH-2 function together in multiple steps of a C. elegans neuronal sublineage ', Development , vol. 127, no. 24, pp. 5415-5426. (elsevier.com)
Subfamily1
- The members of the ubiquitously expressed E-protein subfamily of basic Helix-Loop-Helix (bHLH) transcription factors, E12/E47, SEF2-1 and HEB, have important roles as regulators of gene expression in various differentiation processes, including lymphocyte development and myogenesis. (dissertations.se)
Expression7
- Deletion of the MRF4 transcription activation domain (TAD) or point mutations that abolish MRF4 DNA interactions inhibit HIS3 expression. (nih.gov)
- Within the developing heart, Hand1 expression becomes restricted predominantly to the left ventricle, whereas Hand2 becomes restricted predominantly to the left ventricle, for which findings have shown each Hand factor to be necessary for normal chamber formation. (elsevier.com)
- 1. Activation of transcription factors and induction of gene expression. (brainscape.com)
- Our research demonstrated that this transcription factor is specifically upregulated in ischemic tissue following brain injury, with particularly strong expression in the limbic system, thalamus, and cortex. (stanford.edu)
- Expression of the transcription factors snail, slug, and twist and their clinical significance in human breast cancer. (springer.com)
- found that LSD1 epigenetically suppressed the expression of the gene encoding NOTCH1, enabling the activity of the neuroendocrine cell lineage-associated transcription factor ASCL1. (sciencemag.org)
- The specificity of the dimers depends on several factors: partner choice, phosphorylation, other protein-protein interactions and spatial-temporal expression (Murre et al. (atlasgeneticsoncology.org)
Homodimerization1
- Here, we developed a library of stabilized α-helices of OLIG2 (SAH-OLIG2) to test the capacity of hydrocarbon-stapled peptides to disrupt OLIG2 homodimerization, which drives the development and chemoresistance of glioblastoma multiforme, one of the deadliest forms of human brain cancer. (uu.nl)
Atf41
- We report that thapsigargin induces activating transcription factor-4 (ATF4) in primary cortical neurons (PCNs) derived from rat and APP(Swe) nontransgenic (nTg) and transgenic (Tg) mice. (stanford.edu)
Nuclear5
- Subsequently, we discuss the role of transcription factors nuclear factor (erythroid-derived 2)-like 2 (Nrf2), Myocyte enhancer factor 2 (MEF2), and Forkhead box (FOXO) and their associated posttranslational modifications as it pertains to regulating each of these networks. (degruyter.com)
- TWIST2 contains 2 nuclear localization signals, a basic helix loop helix (bHLH) domain and a TWIST box domain (Modified from Gong and Li, 2002). (atlasgeneticsoncology.org)
- TWIST2 structure includes 2 nuclear localization signals at the N-terminus (aa 31-34, aa 49-53), a basic helix-loop-helix (bHLH) domain (aa 66-117) and a C-terminal TWIST box region (aa 141-160) (Gong and Li, 2002). (atlasgeneticsoncology.org)
- Several previously known partners of STAT1, as well as new partners, were identified by TIC-OATFA, including the upstream stimulatory factors 1 and 2 (USF1, USF2), nuclear factor of activated T cells, TATA box-binding protein, nuclear factor erythroid-derived 2, nuclear factor-kappa B, and nuclear factor 1. (curehunter.com)
- Both USF1 and nuclear factor-kappa B are well known to interact with STAT1, but the other five TFs are previously unreported STAT1 interaction partners. (curehunter.com)
Mice3
- Neurogenin3 (NEUROG3) is a basic helix-loop-helix transcription factor required for development of the endocrine pancreas in mice. (diabetesjournals.org)
- In mice, pancreatic progenitor cells give rise to functional endocrine cells through an endocrine progenitor intermediate that expresses the basic helix-loop-helix (bHLH) transcription factor Neurogenin3 (Neurog3) ( 1 - 4 ). (diabetesjournals.org)
- Two other factors, HEB and E2-2, are also involved in B-cell development, because mice deficient for these factors demonstrate perturbations of B-cell development as well. (bloodjournal.org)