Helix-Loop-Helix Motifs
Basic Helix-Loop-Helix Transcription Factors
Inhibitor of Differentiation Proteins
Hepatocyte Nuclear Factor 3-beta
Hepatocyte Nuclear Factor 3-gamma
Hepatocyte Nuclear Factor 3-alpha
Forkhead Transcription Factors
Transcription Factors
Winged-Helix Transcription Factors
DNA-Binding Proteins
Gene Expression Regulation, Developmental
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Transcription, Genetic
Nuclear Proteins
Base Sequence
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Cell Differentiation
Mice, Transgenic
Mice, Knockout
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Promoter Regions, Genetic
T-Lymphocytes, Regulatory
Helix (Snails)
Amino Acid Sequence
Binding Sites
Sp1 Transcription Factor
Gene Expression Regulation
Protein Binding
Transcriptional Activation
Trans-Activators
Protein Structure, Secondary
Mutation
DNA
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Models, Molecular
Protein Structure, Tertiary
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
Repressor Proteins
Transcription Factor AP-1
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Homeodomain Proteins
Basic-Leucine Zipper Transcription Factors
Transfection
Cell Nucleus
Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
Transcription Factor AP-2
Transcription Factors, TFII
The so-called general transcription factors that bind to RNA POLYMERASE II and that are required to initiate transcription. They include TFIIA; TFIIB; TFIID; TFIIE; TFIIF; TFIIH; TFII-I; and TFIIJ. In vivo they apparently bind in an ordered multi-step process and/or may form a large preinitiation complex called RNA polymerase II holoenzyme.
Kruppel-Like Transcription Factors
HeLa Cells
Genes, Reporter
Sequence Homology, Amino Acid
Cells, Cultured
Nucleic Acid Conformation
Chromatin Immunoprecipitation
A technique for identifying specific DNA sequences that are bound, in vivo, to proteins of interest. It involves formaldehyde fixation of CHROMATIN to crosslink the DNA-BINDING PROTEINS to the DNA. After shearing the DNA into small fragments, specific DNA-protein complexes are isolated by immunoprecipitation with protein-specific ANTIBODIES. Then, the DNA isolated from the complex can be identified by PCR amplification and sequencing.
Recombinant Fusion Proteins
Cloning, Molecular
YY1 Transcription Factor
STAT3 Transcription Factor
Transcription Factor TFIID
The major sequence-specific DNA-binding component involved in the activation of transcription of RNA POLYMERASE II. It was originally described as a complex of TATA-BOX BINDING PROTEIN and TATA-BINDING PROTEIN ASSOCIATED FACTORS. It is now know that TATA BOX BINDING PROTEIN-LIKE PROTEINS may take the place of TATA-box binding protein in the complex.
GATA4 Transcription Factor
Plasmids
Mutagenesis, Site-Directed
Zinc Fingers
Motifs in DNA- and RNA-binding proteins whose amino acids are folded into a single structural unit around a zinc atom. In the classic zinc finger, one zinc atom is bound to two cysteines and two histidines. In between the cysteines and histidines are 12 residues which form a DNA binding fingertip. By variations in the composition of the sequences in the fingertip and the number and spacing of tandem repeats of the motif, zinc fingers can form a large number of different sequence specific binding sites.
Activating Transcription Factor 3
Reverse Transcriptase Polymerase Chain Reaction
NFATC Transcription Factors
A family of transcription factors characterized by the presence of highly conserved calcineurin- and DNA-binding domains. NFAT proteins are activated in the CYTOPLASM by the calcium-dependent phosphatase CALCINEURIN. They transduce calcium signals to the nucleus where they can interact with TRANSCRIPTION FACTOR AP-1 or NF-KAPPA B and initiate GENETIC TRANSCRIPTION of GENES involved in CELL DIFFERENTIATION and development. NFAT proteins stimulate T-CELL activation through the induction of IMMEDIATE-EARLY GENES such as INTERLEUKIN-2.
A conserved motif in goosecoid mediates groucho-dependent repression in Drosophila embryos. (1/5432)
Surprisingly small peptide motifs can confer critical biological functions. One example is the WRPW tetrapeptide present in the Hairy family of transcriptional repressors, which mediates recruitment of the Groucho (Gro) corepressor to target promoters. We recently showed that Engrailed (En) is another repressor that requires association with Gro for its function. En lacks a WRPW motif; instead, it contains another short conserved sequence, the En homology region 1 (eh1)/GEH motif, that is likely to play a role in tethering Gro to the promoter. Here, we characterize a repressor domain from the Goosecoid (Gsc) developmental regulator that includes an eh1/GEH-like motif. We demonstrate that this domain (GscR) mediates efficient repression in Drosophila blastoderm embryos and that repression by GscR requires Gro function. GscR and Gro interact in vitro, and the eh1/GEH motif is necessary and sufficient for the interaction and for in vivo repression. Because WRPW- and eh1/GEH-like motifs are present in different proteins and in many organisms, the results suggest that interactions between short peptides and Gro represent a widespread mechanism of repression. Finally, we investigate whether Gro is part of a stable multiprotein complex in the nucleus. Our results indicate that Gro does not form stable associations with other proteins but that it may be able to assemble into homomultimeric complexes. (+info)Physical interaction of the bHLH LYL1 protein and NF-kappaB1 p105. (2/5432)
The LYL1 gene was first identified upon the molecular characterization of the t(7;9)(q35;p13) translocation associated with some human T-cell acute leukemias (T-ALLs). In adult tissues, LYL1 expression is restricted to hematopoietic cells with the notable exclusion of the T cell lineage. LYL1 encodes a basic helix-loop-helix (bHLH) protein highly related to TAL-1, whose activation is also associated with a high proportion of human T-ALLs. A yeast two-hybrid system was used to identify proteins that specifically interact with LYL1 and might mediate its activities. We found that p105, the precursor of NF-kappaB1 p50, was the major LYL1-interacting protein in this system. The association between LYL1 and p105 was confirmed both in vitro and in vivo in mammalian cells. Biochemical studies indicated that the interaction was mediated by the bHLH motif of LYL1 and the ankyrin-like motifs of p105. Ectopic expression of LYL1 in a human T cell line caused a significant decrease in NF-kappaB-dependent transcription, associated with a reduced level of NF-kappaB1 proteins. (+info)A molecular pathway revealing a genetic basis for human cardiac and craniofacial defects. (3/5432)
Microdeletions of chromosome 22q11 are the most common genetic defects associated with cardiac and craniofacial anomalies in humans. A screen for mouse genes dependent on dHAND, a transcription factor implicated in neural crest development, identified Ufd1, which maps to human 22q11 and encodes a protein involved in degradation of ubiquitinated proteins. Mouse Ufd1 was specifically expressed in most tissues affected in patients with 22q11 deletion syndrome. The human UFD1L gene was deleted in all 182 patients studied with 22q11 deletion, and a smaller deletion of approximately 20 kilobases that removed exons 1 to 3 of UFD1L was found in one individual with features typical of 22q11 deletion syndrome. These data suggest that UFD1L haploinsufficiency contributes to the congenital heart and craniofacial defects seen in 22q11 deletion. (+info)Expression of Mash1 in basal cells of rat circumvallate taste buds is dependent upon gustatory innervation. (4/5432)
Mash1, a mammalian homologue of the Drosophila achaete-scute proneural gene complex, plays an essential role in differentiation of subsets of peripheral neurons. In this study, using RT-PCR and in situ RT-PCR, we investigated if Mash1 gene expression occurs in rat taste buds. Further, we examined dynamics of Mash1 expression in the process of degeneration and regeneration in denervated rat taste buds. In rat tongue epithelium, Mash1 gene expression is confined to circumvallate, foliate, and fungiform papilla epithelia that include taste buds. In taste buds, Mash1-expressing cells are round cells in the basal compartment. In contrast, the mature taste bud cells do not express the Mash1 gene. Denervation and regeneration experiments show that the expression of Mash1 requires gustatory innervation. We conclude that Mash1 is expressed in cells of the taste bud lineage, and that the expression of Mash1 in rat taste buds is dependent upon gustatory innervation. (+info)Dynamic expression of lunatic fringe suggests a link between notch signaling and an autonomous cellular oscillator driving somite segmentation. (5/5432)
The metameric organization of the vertebrate trunk is a characteristic feature of all members of this phylum. The origin of this metamerism can be traced to the division of paraxial mesoderm into individual units, termed somites, during embryonic development. Despite the identification of somites as the first overt sign of segmentation in vertebrates well over 100 years ago, the mechanism(s) underlying somite formation remain poorly understood. Recently, however, several genes have been identified which play prominent roles in orchestrating segmentation, including the novel secreted factor lunatic fringe. To gain further insight into the mechanism by which lunatic fringe controls somite development, we have conducted a thorough analysis of lunatic fringe expression in the unsegmented paraxial mesoderm of chick embryos. Here we report that lunatic fringe is expressed predominantly in somite -II, where somite I corresponds to the most recently formed somite and somite -I corresponds to the group of cells which will form the next somite. In addition, we show that lunatic fringe is expressed in a highly dynamic manner in the chick segmental plate prior to somite formation and that lunatic fringe expression cycles autonomously with a periodicity of somite formation. Moreover, the murine ortholog of lunatic fringe undergoes a similar cycling expression pattern in the presomitic mesoderm of somite stage mouse embryos. The demonstration of a dynamic periodic expression pattern suggests that lunatic fringe may function to integrate notch signaling to a cellular oscillator controlling somite segmentation. (+info)The development and evolution of bristle patterns in Diptera. (6/5432)
The spatial distribution of sensory bristles on the notum of different species of Diptera is compared. Species displaying ancestral features have a simple organization of randomly distributed, but uniformly spaced, bristles, whereas species thought to be more derived bear patterns in which the bristles are aligned into longitudinal rows. The number of rows of large bristles on the scutum was probably restricted to four early on in the evolution of cyclorraphous Brachyceran flies. Most species have stereotyped patterns based on modifications of these four rows. The possible constraints placed upon the patterning mechanisms due to growth and moulting within the Diptera are discussed, as well as within hemimetabolous insects. The holometabolic life cycle and the setting aside of groups of imaginal cells whose function is not required during the growth period, may have provided the freedom necessary for the evolution of elaborate bristle patterns. We briefly review the current state of knowledge concerning the complex genetic pathways regulating achaete-scute gene expression and bristle pattern in Drosophila melanogaster, and consider mechanisms for the genetic regulation of the bristle patterns of other species of Diptera. (+info)Bar homeobox genes are latitudinal prepattern genes in the developing Drosophila notum whose expression is regulated by the concerted functions of decapentaplegic and wingless. (7/5432)
In Drosophila notum, the expression of achaete-scute proneural genes and bristle formation have been shown to be regulated by putative prepattern genes expressed longitudinally. Here, we show that two homeobox genes at the Bar locus (BarH1 and BarH2) may belong to a different class of prepattern genes expressed latitudinally, and suggest that the developing notum consists of checker-square-like subdomains, each governed by a different combination of prepattern genes. BarH1 and BarH2 are coexpressed in the anterior-most notal region and regulate the formation of microchaetae within the region of BarH1/BarH2 expression through activating achaete-scute. Presutural macrochaetae formation also requires Bar homeobox gene activity. Bar homeobox gene expression is restricted dorsally and posteriorly by Decapentaplegic signaling, while the ventral limit of the expression domain of Bar homeobox genes is determined by wingless whose expression is under the control of Decapentaplegic signaling. (+info)Dual role of extramacrochaetae in cell proliferation and cell differentiation during wing morphogenesis in Drosophila. (8/5432)
The Extramacrochaetae (emc) gene encodes a transcription factor with an HLH domain without the basic region involved in interaction with DNA present in other proteins that have this domain. EMC forms heterodimers with bHLH proteins preventing their binding to DNA, acting as a negative regulator. The function of emc is required in many developmental processes during the development of Drosophila, including wing morphogenesis. Mitotic recombination clones of both null and gain-of-function alleles of emc, indicate that during wing morphogenesis, emc participates in cell proliferation within the intervein regions (vein patterning), as well as in vein differentiation. The study of relationships between emc and different genes involved in wing development reveal strong genetic interactions with genes of the Ras signalling pathway (torpedo, vein, veinlet and Gap), blistered, plexus and net, in both adult wing phenotypes and cell behaviour in genetic mosaics. These interactions are also analyzed as variations of emc expression patterns in mutant backgrounds for these genes. In addition, cell proliferation behaviour of emc mutant cells varies depending on the mutant background. The results show that genes of the Ras signalling pathway are co-operatively involved in the activity of emc during cell proliferation, and later antagonistically during cell differentiation, repressing EMC expression. (+info)Genome-wide analysis of basic/helix-loop-helix transcription factor family in rice and Arabidopsis<...
The basic helix-loop-helix transcription factor neuroD is expressed in the rod lineage of the teleost retina. - PubMed - NCBI
Proneural genetic programs include genes required for asymmetric cell division in drosophila
The bHLH transcription factor hand2 is essential for noradrenergic differentiation of sympathetic neurons | Development
Phosphorylation in intrinsically disordered regions regulates the activity of Neurogenin2. - Tufts Digital...
Examination of mammalian basic helix-loop-helix transcription factors using a yeast one-hybrid system
JAIRO | Conformational changes in inhibitory PAS domain protein associated with binding of HIF-1α and Bcl-xL in living cells.
Neurogenin-3 - Wikipedia
HIF1A - Hypoxia inducible factor 1, alpha subunit (Basic helix-loop-helix transcription factor) - Bos taurus (Bovine) - HIF1A...
Distinct domains within Mash1 and Math1 are required for function in neuronal differentiation versus neuronal cell-type...
endothelial PAS domain-containing protein 1
Summary Report | CureHunter
Pro-Photoreceptor Activity of Chick neurogenin1 | IOVS | ARVO Journals
ATOH1 - ويكيبيديا
Mammalian BarH homologue is a potential regulator of neural bHLH genes.
Abstract 14: The Helix-Loop-Helix Transcription Factor nPAS4 Induces Sprouting Angiogenesis and Regulates Tip Cell Formation |...
Genetic risk expressed in early regulator of gene expression | Genes 2 Brains 2 Mind 2 Me
Proneural genes - Wikipedia
Transcription Factor 3
Summary Report | CureHunter
The bHLH factors, dHAND and eHAND, specify pulmonary and systemic cardiac ventricles independent of left-right sidedness
HEA798Hu | 低氧诱导因子1α(HIF1a)检测试剂盒(酶联免疫吸附试验法,高敏型) | Homo sapiens (Human,人) USCN(武汉优尔生商贸有限公司)
Differential genomic targeting of the transcription factor TAL1 in alternate haematopoietic lineages | The EMBO Journal
Cell cycle switch to endocycle: the nucleolus lends a hand. - Physiology, Anatomy and Genetics
Serotonin-Expressing Cells in the Corpus of the Stomach Originate from by Brian T. Johnston
Most recent papers with the keyword ngn2 | Read by QxMD
Human eHAND, but not dHAND, is down-regulated in cardiomyopathies<...
RePub, Erasmus University Repository:
ETO2 coordinates cellular proliferation and differentiation during erythropoiesis
Gene Expression Literature Detail
Transcription Factor 4 (TCF4) Antibody | Abbexa Ltd
Plus it
Expression pattern of the stem cell leukaemia gene in the CNS of the embryonic and adult mouse. - Semantic Scholar
HEY1 hes related family bHLH transcription factor with YRPW motif 1 [Homo sapiens (human)] - Gene - NCBI
HEY1 elisa kit | Dog hairy/enhancer-of-split related with YRPW motif 1 ELISA Kit-NP 001002953.1
Gene Expression Literature Detail
HIF-2 alpha/EPAS1 Antibody (ep190b) [HRP] (NB100-132H): Novus Biologicals
anti-ATOH8 antibody | GeneTex
ASCL2 (achaete-scute family bHLH transcription factor 2) - KOMP (Knockout Mouse Project)
Art of Problem Solving
Art of Problem Solving
Neuronal PAS domain-containing protein 3
Investigating the role for c-myc and bHLH transcription factors in driving phenotypic versatility of cancer stem cells in...
Npas2 - Neuronal PAS domain-containing protein 2 - Mus musculus (Mouse) - Npas2 gene & protein
Atoh8 gene cDNA ORF clone, Mus musculus(house mouse) - GenScript
Nanomaterials | Free Full-Text | Neurogenic Differentiation of Human Dental Pulp Stem Cells on Graphene-Polycaprolactone Hybrid...
Neuronal PAS domain protein 4 (Npas4) controls neuronal homeostasis in pentylenetetrazole-induced epilepsy through the...
Myc Proto Oncogene Protein (Transcription Factor p64 or Class E Basic Helix Loop Helix Protein 39 or MYC) - Pipeline Review, H2...
Mitogen-activated protein kinase phosphorylates and negatively regulates basic helix-loop-helix-PAS transcription factor BMAL1 ...
Genome-Wide Identification and Analysis of the Chicken Basic Helix-Loop-Helix Factors
Class E basic helix-loop-helix protein 23
Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3 -...
Anti-Human Olig2 Antibody | Human Olig2 Antibody | Olig2 Antibody
Anti-Human Olig2 Antibody | Human Olig2 Antibody | Olig2 Antibody
Small molecules enable neurogenin 2 to efficiently convert human fibroblasts into cholinergic neurons<...
ORBi: Browsing ORBi
Differential regulation of granulopoiesis by the basic helix-loop-helix transcriptional inhibitors Id1 and Id2. - Radcliffe...
Oral Presentation - ASN Events
Epigenetic Regulation of Nestin Expression During Neurogenic Differentiation of Adipose Tissue Stem Cells.
2 signals -- from within and out of cell -- specify motor neuron differentiation
twist: A Myogenic Switch in Drosophila | Science
Phospho-regulation of ATOH1 Is Required for Plasticity of Secretory Progenitors and Tissue Regeneration. - MRC Weatherall...
Difference between revisions of Math 764 -- Algebraic Geometry II -- Homeworks - Math
BTZ044 | Targeting NRAS in Melanoma and Acute Myelogenous Leukemia
TCF21 antibodies | Antibodypedia
ID2 (Inhibitor Of DNA Binding 2, Dominant Negative Helix-Loop-Helix Protein)
Anti-NSCL1 (HEN1; Helix-loop-helix protein 1) Polyclonal Antibody, Unconjugated from CHEMICON
OriGene - Heyl (NM 013905) cDNA Clone
Most recent papers with the keyword Therapie | Read by QxMD
The BHLHE40 gene and its putative association with human ageing
jira] [Updated] (MATH-746) Things to do before releasing 3.0
BHLHE40 antibody (OAAB00664) | 2 Homologous species
ID2 - ويكيبيديا
Anti MAX (pSer11) Antibody | Bio-Rad Antibodies (formerly AbD Serotec)
Visualising β-cells in the pancreas | Disease Models & Mechanisms
Factoring Review Worksheet - Lariverannex
anti-HEY1 antibody, C-term | GeneTex
LDPartEditor] 0.8.24 Beta Released (Rounding per X,Y,Z / bugfix)
Algebraic Geometry Seminar Spring 2017 - UW-Math Wiki
900+ Homeschool Math ideas | homeschool math, math, fun math
Mutagenesis of the mouse Bhlhb4 gene. A: Gene targeting | Open-i
Basic helix-loop-helix leucine zipper transcription factors
... are, as their name indicates, transcription factors containing both ... Basic+helix-loop-helix+leucine+zipper+transcription+factors at the US National Library of Medicine Medical Subject Headings ( ... Basic helix-loop-helix and leucine zipper motifs. Examples include Microphthalmia-associated transcription factor and Sterol ... Transcription factors, All stub articles, Genetics stubs). ...
NPAS1
... is a basic helix-loop-helix transcription factor. NPAS3 Zhou YD, Barnard M, Tian H, Li X, Ring HZ, Francke U, Shelton J, ... "Characterization of a subset of the basic helix-loop-helix-PAS superfamily that interacts with components of the dioxin ... Transcription factors, PAS-domain-containing proteins, All stub articles, Human chromosome 19 gene stubs). ...
HLF (gene)
"Entrez Gene: HLF hepatic leukemia factor". LeBrun DP (May 2003). "E2A basic helix-loop-helix transcription factors in human ... This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The ... Transcription factors, All stub articles, Human chromosome 17 gene stubs). ... "Enhanced binding of HLF/DBP heterodimers represents one mechanism of PAR protein transactivation of the factor VIII and factor ...
Neurogenins
Neurogenin 1 (Ngn1) is a Class-A basic-helix-loop-helix (bHLH) transcription factor that acts as a regulator for neuronal ... Li HJ, Ray SK, Singh NK, Johnston B, Leiter AB (Oct 2011). "Basic helix-loop-helix transcription factors and enteroendocrine ... The promotion of GFAP transcription induced glial differentiation. Neurogenin 2 (Ngn2) is a bHLH transcription factor involved ... Another transcription factor that may be a downstream target of Ngn3 is Nkx2.2 because it is often coexpressed with it. Studies ...
ANKS1B
LeBrun DP (2004). "E2A basic helix-loop-helix transcription factors in human leukemia". Front. Biosci. 8 (1-3): s206-22. doi: ... "Regulation of amyloid precursor protein expression and secretion via activation of ERK1/2 by hepatocyte growth factor in HEK293 ...
MYF6
Myogenic factors are basic helix-loop-helix (bHLH) transcription factors. MYF6 is a gene that encodes a protein involved in the ... "A novel type of calmodulin interaction in the inhibition of basic helix-loop-helix transcription factors". Biochemistry. 39 (15 ... "Differential interactions of Id proteins with basic-helix-loop-helix transcription factors". The Journal of Biological ... The portion of the protein integral to myogenesis regulation requires the basic helix-loop-helix (bHLH) domain that is ...
MYF5
... belongs to a family of proteins known as myogenic regulatory factors (MRFs). These basic helix loop helix transcription ... "Differential interactions of Id proteins with basic-helix-loop-helix transcription factors". The Journal of Biological ... MRF family members include Myf5, MyoD (Myf3), myogenin, and MRF4 (Myf6). This transcription factor is the earliest of all MRFs ... As for its clinical significance, the aberration of this transcription factor provides part of the mechanism for how hypoxia ( ...
Cyclin D1
Ratineau C, Petry MW, Mutoh H, Leiter AB (March 2002). "Cyclin D1 represses the basic helix-loop-helix transcription factor, ... Zhang T, Liu WD, Saunee NA, Breslin MB, Lan MS (February 2009). "Zinc finger transcription factor INSM1 interrupts cyclin D1 ... Cyclin D1-CDK4 also associates with several transcription factors and transcriptional co-regulators. Independent of CDK, cyclin ... allowing E2F transcription factors to transcribe genes required for entry into the S phase. Inactive pRb allows cell cycle ...
LOC642658
Basic helix-loop-helix transcription factor scleraxis is a protein that in humans is encoded by the SCXB gene. GRCh38: Ensembl ... "Entrez Gene: LOC642658 similar to Basic helix-loop-helix transcription factor scleraxis". v t e (Articles with short ...
MyoD
... basic helix loop helix) transcription factors act sequentially in myogenic differentiation. Vertebrate MRF family members ... "Differential interactions of Id proteins with basic-helix-loop-helix transcription factors". J. Biol. Chem. 272 (32): 19785-93 ... now referred to as basic helix loop helix) for dimerization and a basic site upstream of this bHLH region facilitated DNA ... Finkel T, Duc J, Fearon ER, Dang CV, Tomaselli GF (January 1993). "Detection and modulation in vivo of helix-loop-helix protein ...
TAL1
The protein encoded by TAL1 is a basic helix-loop-helix transcription factor. TAL1 has been shown to interact with: CBFA2T3, ... Green AR, Begley CG (1993). "SCL and related hemopoietic helix-loop-helix transcription factors". Int. J. Cell Cloning. 10 (5 ... "The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells". Proc. Natl. ... "The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells". Proc. Natl. ...
SIM2
Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors". The Journal of Biological Chemistry. ... Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors". The Journal of Biological Chemistry. ... Ooe N, Saito K, Mikami N, Nakatuka I, Kaneko H (Jan 2004). "Identification of a novel basic helix-loop-helix-PAS factor, NXF, ... Ooe N, Saito K, Mikami N, Nakatuka I, Kaneko H (Jan 2004). "Identification of a novel basic helix-loop-helix-PAS factor, NXF, ...
Pho4
... is a protein with a basic helix-loop-helix (bHLH) transcription factor. It is found in S. cerevisiae and other yeasts. It ... Berben G, Legrain M, Gilliquet V, Hilger F (1990). "The yeast regulatory gene PHO4 encodes a helix-loop-helix motif". Yeast. 6 ... Additionally, another transcription factor known as Pho2, binds to Pho4 and assists in Pho4's ability to bind tightly to its ... The DNA-binding domain of PHO4 consists of two helices, designated H1 and H2, separated by a long loop that contains a novel α- ...
Aryl hydrocarbon receptor nuclear translocator
Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors". J. Biol. Chem. 277 (12): 10236-43. doi: ... Ooe N, Saito K, Mikami N, Nakatuka I, Kaneko H (January 2004). "Identification of a novel basic helix-loop-helix-PAS factor, ... Wang GL, Jiang BH, Rue EA, Semenza GL (1995). "Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated ... "Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin ...
HES1
This protein belongs to the basic helix-loop-helix (bHLH) family of transcription factors. It is a transcriptional repressor of ... Jögi A, Persson P, Grynfeld A, Påhlman S, Axelson H (2002). "Modulation of basic helix-loop-helix transcription complex ... a basic helix-loop-helix repressor of neuronal differentiation". Genes Dev. 11 (23): 3168-81. doi:10.1101/gad.11.23.3168. PMC ... and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-1. Negative autoregulation through the ...
DTX1
... it may play a role in basic helix-loop-helix transcription factor activity. DTX1 has been shown to interact with EP300. GRCh38 ...
ATOH1
2007). "Basic helix-loop-helix transcription factor profiling of lung tumors shows aberrant expression of the proneural gene ... This protein belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent ... "The intestine-specific homeobox gene Cdx2 induces expression of the basic helix-loop-helix transcription factor Math1". ... Leow CC, Polakis P, Gao WQ (November 2005). "A role for Hath1, a bHLH transcription factor, in colon adenocarcinoma". Annals of ...
Sterol regulatory element-binding protein
SREBPs belong to the basic-helix-loop-helix leucine zipper class of transcription factors. Unactivated SREBPs are attached to ... Gasic GP (Apr 1994). "Basic-helix-loop-helix transcription factor and sterol sensor in a single membrane-bound molecule". Cell ... a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene". Cell ... SREBPs have a structure similar to E-box-binding helix-loop-helix (HLH) proteins. However, in contrast to E-box-binding HLH ...
TAL2
... is a member of the basic helix-loop-helix family of transcription factors. Tumor-specific alterations of the TAL2 gene ... Baer R (December 1993). "TAL1, TAL2 and LYL1: a family of basic helix-loop-helix proteins implicated in T cell acute leukaemia ... 1992). "TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia". Proc. Natl. Acad ... a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia". Proc. Natl. Acad. Sci. U.S.A. ...
Ethylin Wang Jabs
... a basic helix-loop-helix transcription factor, in Saethre-Chotzen syndrome". Nature Genetics. 15 (1): 36-41. doi:10.1038/ng0197 ... She discovered that similar mutations in the same gene, fibroblast growth factor receptor 2 or FGFR2, cause both Jackson-Weiss ... "Jackson-Weiss and Crouzon syndromes are allelic with mutations in fibroblast growth factor receptor 2". Nature Genetics. 8 (3 ...
MYCL
... 1 is a bHLH (basic helix-loop-helix) transcription factor implicated in lung cancer. MYCL1 has been shown to interact with ... Blackwood EM, Eisenman RN (Mar 1991). "Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding ... Lüscher B (2001). "Function and regulation of the transcription factors of the Myc/Max/Mad network". Gene. 277 (1-2): 1-14. doi ... Transcription factors, All stub articles, Human chromosome 1 gene stubs). ...
TCF21 (gene)
TCF21 encodes a transcription factor of the basic helix-loop-helix (bHLH) family, which manages cell-fate specification, ... Lu J, Chang P, Richardson JA, Gan L, Weiler H, Olson EN (August 2000). "The basic helix-loop-helix transcription factor ... Funato N, Ohyama K, Kuroda T, Nakamura M (February 2003). "Basic helix-loop-helix transcription factor epicardin/capsulin/Pod-1 ... basic helix-loop-helix) family of transcription factors. This protein is predicted to span 179 amino acid residues and contains ...
NEUROD2
"Interaction of PKN with a neuron-specific basic helix-loop-helix transcription factor, NDRF/NeuroD2". Brain Research. Molecular ... "Interaction of PKN with a neuron-specific basic helix-loop-helix transcription factor, NDRF/NeuroD2". Brain Research. Molecular ... This gene encodes a member of the neuroD family of neurogenic basic helix-loop-helix (bHLH) proteins. Expression of this gene ... a NeuroD family basic helix-loop-helix protein". Brain Research. Molecular Brain Research. 60 (1): 107-14. doi:10.1016/S0169- ...
Mef2
"Combinatorial control of muscle development by basic helix-loop-helix and MADS-box transcription factors". Proc Natl Acad Sci ... Mef2c upregulates the expression of the homeodomain transcription factors DLX5 and DLX6, two transcription factors that are ... MEF2, Myocyte Enhancer Factor 2, is a transcription factor with four specific numbers such as MEF2A, B, C, and D. Each MEF2 ... "Myocyte Enhancer Factor 2 Transcription Factors in Heart Development and Disease." Heart Development and Regeneration, 2010, pp ...
Class A basic helix-loop-helix protein 15
Lemercier C, To RQ, Carrasco RA, Konieczny SF (1998). "The basic helix-loop-helix transcription factor Mist1 functions as a ... Class A basic helix-loop-helix protein 15 (bHLHa15) also known as class B basic helix-loop-helix protein 8 (bHLHb8) or muscle, ... 2006). "Identification of a basic helix-loop-helix transcription factor expressed in mammary gland alveolar cells and required ... 1997). "Mist1: a novel basic helix-loop-helix transcription factor exhibits a developmentally regulated expression pattern". ...
OLIG1
"Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors". Neuron. 25 ... McLellan AS, Langlands K, Kealey T (Dec 2002). "Exhaustive identification of human class II basic helix-loop-helix proteins by ... McLellan AS, Langlands K, Kealey T (Dec 2002). "Exhaustive identification of human class II basic helix-loop-helix proteins by ... "Dynamic expression of basic helix-loop-helix Olig family members: implication of Olig2 in neuron and oligodendrocyte ...
Protein kinase N1
"Interaction of PKN with a neuron-specific basic helix-loop-helix transcription factor, NDRF/NeuroD2". Brain Res. Mol. Brain Res ... which is a potential transcription factor". Exp. Cell Res. 241 (2): 363-72. doi:10.1006/excr.1998.4060. PMID 9637778. Takahashi ...
Myogenic determination factor 5
"Combinatorial control of muscle development by basic helix-loop-helix and MADS-box transcription factors". Proc. Natl. Acad. ... A C-terminal Myf5 domain, a central basic helix-loop-helix (bHLH) domain and an N-terminal basic domain. The bHLH region ... Hamamori Y, Wu HY, Sartorelli V, Kedes L (November 1997). "The basic domain of myogenic basic helix-loop-helix (bHLH) proteins ... With 12 residues of the basic domain involved in DNA binding. The basic domain forms an extended alpha helix in the structure. ...
ASCL2
This gene is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by ... is a maternally expressed imprinted gene that codes is a part of the basic helix-loop-helix (BHLH) transcription factor family ... "A novel type of calmodulin interaction in the inhibition of basic helix-loop-helix transcription factors". Biochemistry. 39 (15 ... possible role of placenta-specific basic helix-loop-helix transcription factor, human achaete-scute homologue-2". Journal of ...
ARNTL
... encodes a transcription factor with a basic helix-loop-helix (bHLH) and two PAS domains. The human ARNTL gene has a ... that encodes for a basic helix-loop-helix PAS domain transcription factor. It, too, has been shown to play a circadian role, ... "Mitogen-activated protein kinase phosphorylates and negatively regulates basic helix-loop-helix-PAS transcription factor BMAL1 ... Ooe N, Saito K, Mikami N, Nakatuka I, Kaneko H (January 2004). "Identification of a novel basic helix-loop-helix-PAS factor, ...
Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation
The basic helix-loop-helix transcription factor capsulin controls spleen organogenesis<...
The basic helix-loop-helix transcription factor capsulin controls spleen organogenesis. Jianrong Lu, Priscilla Chang, James A. ... The basic helix-loop-helix transcription factor capsulin controls spleen organogenesis. Proceedings of the National Academy of ... The basic helix-loop-helix transcription factor capsulin controls spleen organogenesis. In: Proceedings of the National Academy ... Lu, J, Chang, P, Richardson, JA, Gan, L, Weiler, H & Olson, EN 2000, The basic helix-loop-helix transcription factor capsulin ...
TWIST1 gene: MedlinePlus Genetics
Specifically, the TWIST1 protein is part of a large protein family called basic helix-loop-helix (bHLH) transcription factors. ... This protein is a transcription factor, which means that it attaches (binds) to specific regions of DNA and controls the ... The bHLH family of transcription factors helps regulate the development of many organs and tissues before birth. ... twist basic helix-loop-helix transcription factor 1. *Twist Homolog. *twist homolog 1 (acrocephalosyndactyly 3; Saethre-Chotzen ...
EMT, MET, Plasticity, and Tumor Metastasis: Trends in Cell Biology
Twist-related protein 1/2; basic helix-loop-helix transcription factors. Cells undergoing EMT demonstrate increased expression ... SRY-box transcription factor 4; a member of the SOX family of transcription factors important in regulating the expression of ... zinc-finger E-box-binding homeobox 1/2; Zeb1 and Zeb2 are paralogs belonging to the Zeb family of transcription factors. They ... the gene that encodes Snai2/Snail2, a zinc-finger transcription factor involved in the promotion of EMT. ...
Somatic HIF2A gain-of-function mutations in paraganglioma with polycythemia
However, mutations in genes encoding α subunits of hypoxia-inducible factors (HIF-α … ... Hypoxia-inducible factors are transcription factors controlling energy, iron metabolism, erythropoiesis, and development. When ... Basic Helix-Loop-Helix Transcription Factors / genetics* * Basic Helix-Loop-Helix Transcription Factors / metabolism ... Hypoxia-inducible factors are transcription factors controlling energy, iron metabolism, erythropoiesis, and development. When ...
TCF23 transcription factor 23 [Homo sapiens (human)] - Gene - NCBI
transcription factor 23. Names. class A basic helix-loop-helix protein 24. class II basic helix-loop-helix protein TCF23. ... Transcription factor 23 (Tcf23), a basic-helix-loop-helix transcription factor, is a new progesterone-induced target gene that ... OUT, a novel basic helix-loop-helix transcription factor with an Id-like inhibitory activity. Narumi O, et al. J Biol Chem, ... The gene encodes a member of the basic helix-loop-helix transcription factor family. Studies of the orthologous gene in mouse ...
Olig2 MGI Mouse Gene Detail - MGI:1355331 - oligodendrocyte transcription factor 2
Ribosome Incorporation into Somatic Cells Promotes Lineage Transdifferentiation towards Multipotency | Scientific Reports
However, the bacterium-intrinsic cellular- transdifferentiation factor remained unknown. Here, we found that cellular ... TWIST family of basic helix-loop-helix transcription factors mediate human mesenchymal stem cell growth and commitment. Stem ... Furthermore, induced pluripotent stem (iPS) cells can be generated by forced expression of specific transcription factors2. A ... 3c), and immunocytochemistry revealed that NANOG and the pluripotent transcription factors POU5F1 (OCT4), SOX2, and SSEA4 were ...
Biblio | Page 3 | Linus Pauling Institute | Oregon State University
Arthur S Lee, Ph.D. | Harvard Catalyst Profiles | Harvard Catalyst
MMRRC:043392-MU
Multifunctional glial support by Semper cells in the Drosophila retina | PLOS Genetics
Further, we demonstrate that three factors associated with gliogenesis in vertebrates-prospero/Prox1, Pax2, and Oli/Olig1,2- ... Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors. Neuron. 2000 ... This analysis showed transient expression of the transcription factors Olig1,2/Oli, Rx/Rax, Hes1/dpn, Hes5/E(spl), Hey2/Hey, ... The bHLH transcription factors OLIG2 and OLIG1 couple neuronal and glial subtype specification. Cell. 2002;109: 61-73. pmid: ...
Subject: basic-leucine zipper transcription factors / Subject term: basic-leucine zipper transcription factors - PubAg Search...
... basic helix-loop-helix transcription factors; basic-leucine zipper transcription factors; beta-amylase; carbohydrate content; ... basic-leucine zipper transcription factors Remove constraint Subject: basic-leucine zipper transcription factors Subject term ... basic-leucine zipper transcription factors Remove constraint Subject term: basic-leucine zipper transcription factors Start ... BACKGROUND: The basic leucine zipper (bZIP) transcription factor is one of the most abundant and conserved transcription factor ...
Plus it
2000) Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors. Neuron ... Other transcription factors, including Ying Yang 1 and members of Sox family of transcription factors, including Sox9, Sox10, ... whereas nuclear factor I-A/B and bHLH transcription factors, stem cell leukemia, and KLF15 (Krüppel-like factor 15) were found ... Serum response factor (SRF) is a stimulus-dependent transcription factor required for differentiation and development of ...
Frontiers | Attenuated Negative Feedback in Monocyte-Derived Macrophages From Persons Living With HIV: A Role for IKAROS
The mechanism of this reduction in negative feedback involves the attenuated expression of IKZF1, a transcription factor ... The mechanism of this reduction in negative feedback involves the attenuated expression of IKZF1, a transcription factor ... is a basic helix-loop-helix (bHLH) transcription factor (TF) that inhibits other bHLH TFs. Gelsolin (GSN) is an actin-binding ... Transcription Factor PRDII-BF1 Activates Human Immunodeficiency Virus Type 1 Gene Expression. J Virol (1994) 68(2):1002-9. doi ...
IJMS | Free Full-Text | Anaphylaxis: Focus on Transcription Factor Activity
... focusing on the transcription factors contributions to this systemic hypersensitivity reaction. Host mutation in transcription ... While many molecules are involved in cellular regulation, the expression and regulation of transcription factors involved in ... factor expression, or deregulation of their activity in an anaphylaxis context, will be updated. So far, the risk of ... The MiTF/TFE family of basic helix-loop-helix leucine zipper (b-HLH-LZ) transcription factors includes MITF, TFEB, TFE3, and ...
Recombinant Human DTX1 GST (N-Term) Protein (H00001840-P01): Novus Biologicals
Márcia MARGIS-PINHEIRO | Professor (Full) | PhD | Universidade Federal do Rio Grande do Sul, Porto Alegre | UFRGS |...
We have characterised the role of OsICE1, a basic helix-loop-helix (bHLH) transcription factor from rice (Oryza sativa L.), in ... In this study, we focus on the functional characterization of OsbHLH35, a basic Helix-Loop-Helix (bHLH) TF that regulates ... Growth Regulating Factors (GRFs) comprise a transcription factor family with important functions in plant growth and ... OsICE1 transcription factor improves photosynthetic performance and reduces grain losses in rice plants subjected to drought ...
Sex related expressivity of the phenotype in coronal craniosynostosis caused by the recurrent P250R FGFR3 mutation | Journal of...
1997) Mutations in TWIST, a basic helix-loop-helix transcription factor, in Saethre-Chotzen syndrome. Nat Genet 15:36-41. ... 1997) Prevalence of Pro250Arg mutation of fibroblast growth factor receptor 3 in coronal craniosynostosis. Lancet 349:1059-1062 ... 1997) A unique point mutation in the fibroblast growth factor receptor 3 (FGFR3) gene defines a new craniosynostosis syndrome. ... A recurrent point mutation in the fibroblast growth factor receptor 3 (FGFR3) gene that converts proline 250 into arginine is ...
Lateral line placodes of aquatic vertebrates are evolutionarily conserved in mammals | Biology Open | The Company of Biologists
... a proneural gene of the basic helix-loop-helix (bHLH) family of transcription factors. Accordingly, Ngn1+ neuroblasts were ... A mammalian helix-loop-helix factor structurally related to the product of Drosophila proneural gene atonal is a positive ... 4G-I). This T-box transcription factor is specifically upregulated in the lateral line placodes of anamniotes (Schlosser, 2006 ... neurogenins, a novel family of atonal-related bHLH transcription factors, are putative mammalian neuronal determination genes ...
NIOSHTIC-2 Search Results - Full View
Kaninchen HIF1A ELISA Kit | Produkt Nr. ABIN6956648
Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) ELISA Kit Small Sample HIF1A ... Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) ELISA Kit HIF1A Reaktivität: ... Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) ELISA Kit HIF1A Reaktivität: ... Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) ELISA Kit HIF1A Reaktivität: ...
EVPP Departments - Scholarly Works - Arizona State University
Table of Contents - September 01, 2021, 8 (5) | eNeuro
A structural variant in the 5'-flanking region of the TWIST2 gene affects melanocyte development in belted cattle | PLOS ONE
TWIST2 is a basic helix loop helix (bHLH) transcription factor with a postulated role in early development influencing ... 1993) Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix ... bHLH transcription factors are known to dimerize via their bHLH domain and each monomer binds to one halfsite of the DNA ... MITF is also a bHLH transcription factor absolutely required for the development of melanocytes. TWIST2 has been reported to ...
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Scientific Publications since 2002 | Max Planck Institute for Plant Breeding Research
Heim, M. A.; Jakoby, M.; Werber, M.; Martin, C.; Weisshaar, B.; Bailey, P. C.: The basic helix-loop-helix transcription factor ... Update on the basic helix-loop-helix transcription factor gene family in Arabidopsis thaliana. Plant Cell 15 (11), pp. 2497 - ... A systematic survey in Arabidopsis thaliana of transcription factors that modulate circadian parameters. BMC Genomics 9, p. 182 ...
GenAge Human Genes: List of Entries
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor). 17. 62. ... heat shock transcription factor 1. 23. 31. HSP90AA1. 74. heat shock protein 90kDa alpha (cytosolic), class A member 1. 10. 133 ... nuclear factor, erythroid 2-like 2. 7. 36. NFKB1. 82. nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. 25 ... eukaryotic translation elongation factor 1 alpha 1. 5. 43. EEF1E1. 266. eukaryotic translation elongation factor 1 epsilon 1. 3 ...
Leucine zipperBHLH transcriptionGenesProteinsProteinMetabolismArabidopsisRegulateCellsBindEndogenousOligodendrocyteEpithelialGene familyModulateOlig1FAMILYGerminationInhibitoryDroughtFibroblastNeuralExpressionCellularMutationsStemRegionPrimordiaActivityDevelopmentRoleRegulationDifferentiationSpecific
Leucine zipper4
- The MITF gene encodes a transcription factor containing a basic-helix-loop-helix-leucine zipper. (medscape.com)
- Basic region/leucine zipper (bZIP) transcription factors play important roles in the abscisic acid (ABA) signaling pathway and abiotic stress response in plants. (usda.gov)
- TFE3 is a ubiquitously expressed 50 kDa transcription factor containing both basic helix-loop-helix (bHLH) and leucine zipper (ZIP) motifs. (bdbiosciences.com)
- This process is mainly determined by the actions of microphthalmia-associated transcription factor (MITF), a basic-helix-loop-helix and leucine zipper transcription factor, which functions as the master gene for melanocyte survival. (cosmeticsandtoiletries.com)
BHLH transcription6
- Specifically, the TWIST1 protein is part of a large protein family called basic helix-loop-helix (bHLH) transcription factors. (medlineplus.gov)
- It was reported that the basic helix-loop-helix ( bHLH ) transcription factors play vital roles in the process of chlorophyll metabolism. (biomedcentral.com)
- Basic Helix-Loop-Helix ( bHLH ) transcription factor family is the second largest gene families in plant kingdom, usually classified into 15-26 subfamilies. (biomedcentral.com)
- BHLH transcription factors have a highly conserved bHLH domain with ∼ 60 amino acids, which comprises a basic region followed by two amphipathic α-helices separated by a variable loop region (HLH) [ 5 ]. (biomedcentral.com)
- Basic helix-loop-helix (bHLH) transcription factors regulate various aspects of tissue development, and we have previously identified a bHLH transcription factor, AmeloD, from a tooth germ cDNA library. (jbc.org)
- achaete-scute family bHLH transcription. (wikigenes.org)
Genes9
- This protein is a transcription factor, which means that it attaches (binds) to specific regions of DNA and controls the activity of particular genes. (medlineplus.gov)
- However, mutations in genes encoding α subunits of hypoxia-inducible factors (HIF-α) have not previously been identified in any cancer. (nih.gov)
- The genes up-regulated by this transcription factor during embryogenesis have not been identified. (medscape.com)
- Innate host defense requires TFEB-mediated transcription of cytoprotective and antimicrobial genes. (umassmed.edu)
- The basic region is relevant to the DNA binding that allows the bHLH proteins binding to the cis-acting elements in the promoter regions of the target genes, and the HLH region functions as a dimerization domain that allows the formation of homo- and/or heterodimers. (biomedcentral.com)
- Some of these factors implicated in retinal development and regeneration are members of the Hairy/Enhancer of Split (Hes) superfamily of genes, including the Hairy-related (Her) factors Her4 and Her9. (uky.edu)
- Her transcription factors are basic-helix-loop-helix-orange (bHLH-O) transcription factors that bind to palindromic E- and N-box canonical sequences in the promoters of target genes. (uky.edu)
- Many transcription factors and genes related to the photoperiod and GA pathways, floral organ identity, and the anthocyanin biosynthesis pathway were differentially expressed between the normal and mutant capitula. (researchsquare.com)
- It represses GENETIC TRANSCRIPTION of target genes by recruiting HISTONE DEACETYLASES . (nih.gov)
Proteins5
- Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening. (nih.gov)
- These include ion-transport proteins (Na/K+-ATPase, Eaat1, and Kir4.1-related channels) and metabolic homeostatic factors (dLDH and Glut1). (plos.org)
- It also is a key factor in regulating the transcription of the major melanogenic proteins, including tyrosinase and tyrosinase-related proteins (TRP) 1 and 2, which lead to pigmentation. (cosmeticsandtoiletries.com)
- These results support the hypothesis that the evolutionarily unrelated blue-light receptors, cryptochrome and LOV-domain F-box proteins, mediate blue-light regulation of the same transcription factor by distinct mechanisms. (escholarship.org)
- In the CYTOPLASM , I-kappa B proteins bind to the transcription factor NF-KAPPA B. Cell stimulation causes its dissociation and translocation of active NF-kappa B to the nucleus. (bvsalud.org)
Protein4
- Studies of the orthologous gene in mouse have shown the encoded protein does not bind DNA but may negatively regulate other basic helix-loop-helix factors via the formation of a functionally inactive heterodimeric complex. (nih.gov)
- Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. (novusbio.com)
- The basic helix-loop-helix transcription factor family in plants: A genome-wide study of protein structure and functional diversity. (mpg.de)
- In this study we present a variety of automated methods for visualisation of a protein-protein interaction network, using the basic helix-loop-helix (bHLH) family of transcription factors as an example. (sciweavers.org)
Metabolism1
- TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop. (umassmed.edu)
Arabidopsis4
- A systematic survey in Arabidopsis thaliana of transcription factors that modulate circadian parameters. (mpg.de)
- Update on the basic helix-loop-helix transcription factor gene family in Arabidopsis thaliana. (mpg.de)
- Arabidopsis CRY2 and ZTL mediate blue-light regulation of the transcription factor CIB1 by distinct mechanisms. (escholarship.org)
- In Arabidopsis, the photoexcited cryptochrome 2 interacts with the transcription factor CRYPTOCHROME-INTERACTING basic helix-loop-helix 1 (CIB1) to activate transcription and floral initiation. (escholarship.org)
Regulate3
- The bHLH family of transcription factors helps regulate the development of many organs and tissues before birth. (medlineplus.gov)
- The SOX10 gene encodes a member of the high-mobility group-domain Sox family of transcription factors that regulate neural crest development. (medscape.com)
- May also negatively regulate bHLH-mediated transcription through an N-terminal repressor domain. (nih.gov)
Cells8
- Capsulin is a basic helix-loop-helix transcription factor expressed in mesenchymal cells that encapsulate the epithelial primordia of internal organs, including the kidney and lung, as well as the epicardium, which gives rise to the coronary arteries. (elsevier.com)
- A murine uterine transcriptome, responsive to steroid receptor coactivator-2, reveals transcription factor 23 as essential for decidualization of human endometrial stromal cells. (nih.gov)
- Furthermore, induced pluripotent stem (iPS) cells can be generated by forced expression of specific transcription factors 2 . (nature.com)
- Bacteria have been shown to affect human cellular differentiation, but the developmental effect of bacteria remains unclear because the bacterium-intrinsic transforming factors that covert somatic cells into cells that can differentiate into the three germ layers have not been identified. (nature.com)
- Specifically, we show that distinct support functions (neuronal activity, structural integrity and sustained neurotransmission) can be genetically separated in cone cells by down-regulating transcription factors associated with vertebrate gliogenesis ( pros/Prox1 , Pax2/5/8 , and Oli/Olig1 , 2 , respectively). (plos.org)
- Further, we find that specific factors critical for glial function in other species are also critical in cone cells to support Drosophila photoreceptor activity. (plos.org)
- Here we show that deletion of the stimulus-dependent transcription factor, serum response factor (SRF), in neural precursor cells (NPCs) ( Srf -Nestin-cKO) results in nearly 60% loss in astrocytes and 50% loss in oligodendrocyte precursors at birth. (jneurosci.org)
- Cells were fixed and permeabilized with Transcription Factor Staining Buffer Kit (PF00011). (ptglab.com)
Bind1
- They bind with basic helix-loop-helix (bHLH) type TRANSCRIPTION FACTORS . (nih.gov)
Endogenous2
- We show that repression of germination by FR light involves stabilized DELLA factors GAI, RGA and RGL2 that stimulate endogenous ABA synthesis. (unige.ch)
- Flowering, which is a key developmental process in the plant life cycle, is a very complex process controlled by endogenous factors and environmental cues. (researchsquare.com)
Oligodendrocyte1
- Previous studies have widely characterized the signaling pathways important for astrocyte differentiation and unveiled a number of transcription factors that guide oligodendrocyte differentiation in the CNS. (jneurosci.org)
Epithelial2
- Transcription factor TFEB cell-autonomously modulates susceptibility to intestinal epithelial cell injury in vivo. (umassmed.edu)
- The change in the epithelial and mesenchymal gene expression that occurs during EMT is regulated by multiple transcription factor families, including SNAI1/Snail, ZEB1/ZEB2, and basic helix-loop-helix transcription factors (bHLH). (abcam.com)
Gene family1
- 1 Phenotypically distinct entities including Crouzon, Apert, Pfeiffer, and Jackson-Weiss syndromes have been ascribed to mutations in three members of the fibroblast growth factor receptors (FGFRs) gene family, while mutations in the TWIST gene specifically account for the Saethre-Chotzen syndrome. (bmj.com)
Modulate1
- To determine the possible roles of her4 and her9 factors in the retina, I characterized the expression patterns of these factors during developmental retinal neurogenesis and/or regeneration, examined loss of function phenotypes, and identified signaling pathways that modulate expression of these factors. (uky.edu)
Olig11
- Further, we demonstrate that three factors associated with gliogenesis in vertebrates- prospero/Prox1 , Pax2 , and Oli/Olig1 , 2 -control genetically distinct aspects of these support functions. (plos.org)
FAMILY3
- The gene encodes a member of the basic helix-loop-helix transcription factor family. (nih.gov)
- It has also been reported that deficiency in Nkx2-3 , encoding a member of the NK2 homeobox family of transcription factors, leads to cusp absence in affected teeth. (jbc.org)
- A family of DNA -binding transcription factors that contain a basic HELIX-LOOP-HELIX MOTIF. (bvsalud.org)
Germination1
- In turn, ABA blocks germination through the transcription factor ABI3. (unige.ch)
Inhibitory1
- OUT, a novel basic helix-loop-helix transcription factor with an Id-like inhibitory activity. (nih.gov)
Drought1
- In response to environmental stresses, fluctuations in the expression of miRNAs can be induced by many uncontrolled factors, such as drought, salinity, and alkalinity at transcriptional and post-transcriptional levels. (biomedcentral.com)
Fibroblast3
- Apert, Pfeiffer, Jackson-Weiss, and Crouzon syndromes result from mutations in the fibroblast growth factor receptor-2 ( FGFR2 ) gene, which maps to band 10q25-q26. (medscape.com)
- Some patients with Pfeiffer syndrome have demonstrated mutations in the fibroblast growth factor receptor-1 ( FGFR1 ) gene, which maps to band 8p11.2-12. (medscape.com)
- A recurrent point mutation in the fibroblast growth factor receptor 3 (FGFR3) gene that converts proline 250 into arginine is commonly associated with coronal craniosynostosis and has allowed definition of a new syndrome on a molecular basis. (bmj.com)
Neural1
- Her factors have been previously shown to play roles in a diverse array of developmental and neurogenic processes, including neural tube closure, floor plate development, somitogenesis, and development of various components of the central nervous system as well as the cranial sensory placodes. (uky.edu)
Expression5
- A census of human transcription factors: function, expression and evolution. (nih.gov)
- Interestingly, ectopic expression of a constitutively active SRF (SRF-VP16) in NPCs augmented astrocyte differentiation in the presence of pro-astrocytic factors. (jneurosci.org)
- The mechanism of this reduction in negative feedback involves the attenuated expression of IKZF1, a transcription factor required for de novo synthesis of RELA during LPS-induced inflammatory responses. (frontiersin.org)
- In this study, we investigated whether arsenite induces expression of hypoxia-inducible factor 1 (HIF-1). (cdc.gov)
- All of these processes rely on the tight coordination of extrinsic and intrinsic cues, as well as regulation of gene expression by transcription factors. (uky.edu)
Cellular1
- However, the bacterium-intrinsic cellular- transdifferentiation factor remained unknown. (nature.com)
Mutations1
- Here we report two novel somatic gain-of-function mutations in the gene encoding hypoxia-inducible factor 2α (HIF2A) in two patients, one presenting with paraganglioma and the other with paraganglioma and somatostatinoma, both of whom had polycythemia. (nih.gov)
Stem1
- The proliferation and differentiation of melanocytes are believed to be regulated by the keratinocyte-derived factors α-MSH, adrenocorticotropic hormone (ACTH), stem cell factor (SCF) and endothelin-1 (ET-1) (see Figure 4 ). (cosmeticsandtoiletries.com)
Region1
- Binding results in transcriptional activation and is mediated through the basic region located just N-terminal to the HLH domain. (bdbiosciences.com)
Primordia1
- One of the first steps once plants are committed to flowering is the induction of the plant-specific transcription factor LEAFY in the incipient flower primordia. (upsc.se)
Activity1
- however, it may play a role in basic helix-loop-helix transcription factor activity. (novusbio.com)
Development3
- The PAX3 gene encodes a transcription factor with a paired box domain, an octapeptide domain, and a homeobox domain essential for survival of melanocytes during development. (medscape.com)
- Although a considerable amount of work has been conducted to identify key regulators of retinal development and regeneration, many gene regulatory networks which include both master signaling pathways as well as individual transcription factors remain poorly characterized. (uky.edu)
- The mutated gene, PORCUPINE , encodes a putative splice factor, suggesting that alternative splicing of pre-mRNA might be involved in modulating growth and development in response to changes in ambient temperature and might contribute to establish phenotypic plasticity in plants. (upsc.se)
Role1
- E-boxes play a regulatory role in the control of transcription. (nih.gov)
Regulation1
- There is increasing evidence that microRNAs (miRNAs), ~21 nucleotides (nt) in length, act as key factors in gene regulation, developmental processes and stress tolerance in plants [ 3 - 5 ]. (biomedcentral.com)
Differentiation1
- However, SRF-deficient NPCs generated fewer astrocytes and oligodendrocytes in response to several lineage-specific differentiation factors. (jneurosci.org)
Specific1
- The gene for alpha-MSH is encoded for by the POMC gene, but alpha-MSH cannot be produced from POMC gene transcription and translation without these specific post-translational proteolytic steps taking place. (embl-heidelberg.de)