Basic helix-loop-helix (bHLH) domain-containing proteins that play important roles in CIRCADIAN RHYTHM regulation. They combine with CLOCK PROTEINS to form heterodimeric transcription factors that are specific for E-BOX ELEMENTS and stimulate the transcription of several E-box genes that are involved in cyclical regulation.
Recurring supersecondary structures characterized by 20 amino acids folding into two alpha helices connected by a non-helical "loop" segment. They are found in many sequence-specific DNA-BINDING PROTEINS and in CALCIUM-BINDING PROTEINS.
A family of DNA-binding transcription factors that contain a basic HELIX-LOOP-HELIX MOTIF.
Inhibitor of differentiation proteins are negative regulators of BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS. They inhibit CELL DIFFERENTIATION and induce CELL PROLIFERATION by modulating different CELL CYCLE regulators.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs and stimuli, hormone secretion, sleeping, and feeding.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Basic helix-loop-helix (bHLH) domain-containing proteins that contain intrinsic HISTONE ACETYLTRANSFERASE activity and play important roles in CIRCADIAN RHYTHM regulation. Clock proteins combine with Arntl proteins to form heterodimeric transcription factors that are specific for E-BOX ELEMENTS and stimulate the transcription of several E-box genes that are involved in cyclical regulation. This transcriptional activation also sets into motion a time-dependent feedback loop which in turn down-regulates the expression of clock proteins.
Systematic identification, development, organization, or utilization of educational resources and the management of these processes. It is occasionally used also in a more limited sense to describe the use of equipment-oriented techniques or audiovisual aids in educational settings. (Thesaurus of ERIC Descriptors, December 1993, p132)
DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Promoter-specific RNA polymerase II transcription factor that binds to the GC box, one of the upstream promoter elements, in mammalian cells. The binding of Sp1 is necessary for the initiation of transcription in the promoters of a variety of cellular and viral GENES.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
Circadian rhythm signaling proteins that influence circadian clock by interacting with other circadian regulatory proteins and transporting them into the CELL NUCLEUS.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
Processes that stimulate the GENETIC TRANSCRIPTION of a gene or set of genes.
Diffusible gene products that act on homologous or heterologous molecules of viral or cellular DNA to regulate the expression of proteins.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.
Established cell cultures that have the potential to propagate indefinitely.
A multiprotein complex composed of the products of c-jun and c-fos proto-oncogenes. These proteins must dimerize in order to bind to the AP-1 recognition site, also known as the TPA-responsive element (TRE). AP-1 controls both basal and inducible transcription of several genes.
Proteins which maintain the transcriptional quiescence of specific GENES or OPERONS. Classical repressor proteins are DNA-binding proteins that are normally bound to the OPERATOR REGION of an operon, or the ENHANCER SEQUENCES of a gene until a signal occurs that causes their release.
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Proteins encoded by homeobox genes (GENES, HOMEOBOX) that exhibit structural similarity to certain prokaryotic and eukaryotic DNA-binding proteins. Homeodomain proteins are involved in the control of gene expression during morphogenesis and development (GENE EXPRESSION REGULATION, DEVELOPMENTAL).
A subclass of winged helix DNA-binding proteins that share homology with their founding member fork head protein, Drosophila.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.
Tests based on the biochemistry and physiology of the exocrine pancreas and involving analysis of blood, duodenal contents, feces, or urine for products of pancreatic secretion.
A large superfamily of transcription factors that contain a region rich in BASIC AMINO ACID residues followed by a LEUCINE ZIPPER domain.
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
A family of DNA binding proteins that regulate expression of a variety of GENES during CELL DIFFERENTIATION and APOPTOSIS. Family members contain a highly conserved carboxy-terminal basic HELIX-TURN-HELIX MOTIF involved in dimerization and sequence-specific DNA binding.
Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
A family of zinc finger transcription factors that share homology with Kruppel protein, Drosophila. They contain a highly conserved seven amino acid spacer sequence in between their ZINC FINGER MOTIFS.
The so-called general transcription factors that bind to RNA POLYMERASE II and that are required to initiate transcription. They include TFIIA; TFIIB; TFIID; TFIIE; TFIIF; TFIIH; TFII-I; and TFIIJ. In vivo they apparently bind in an ordered multi-step process and/or may form a large preinitiation complex called RNA polymerase II holoenzyme.
Genes whose expression is easily detectable and therefore used to study promoter activity at many positions in a target genome. In recombinant DNA technology, these genes may be attached to a promoter region of interest.
The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.
A technique for identifying specific DNA sequences that are bound, in vivo, to proteins of interest. It involves formaldehyde fixation of CHROMATIN to crosslink the DNA-BINDING PROTEINS to the DNA. After shearing the DNA into small fragments, specific DNA-protein complexes are isolated by immunoprecipitation with protein-specific ANTIBODIES. Then, the DNA isolated from the complex can be identified by PCR amplification and sequencing.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
A ubiquitously expressed zinc finger-containing protein that acts both as a repressor and activator of transcription. It interacts with key regulatory proteins such as TATA-BINDING PROTEIN; TFIIB; and ADENOVIRUS E1A PROTEINS.
A signal transducer and activator of transcription that mediates cellular responses to INTERLEUKIN-6 family members. STAT3 is constitutively activated in a variety of TUMORS and is a major downstream transducer for the CYTOKINE RECEPTOR GP130.
The major sequence-specific DNA-binding component involved in the activation of transcription of RNA POLYMERASE II. It was originally described as a complex of TATA-BOX BINDING PROTEIN and TATA-BINDING PROTEIN ASSOCIATED FACTORS. It is now know that TATA BOX BINDING PROTEIN-LIKE PROTEINS may take the place of TATA-box binding protein in the complex.
A GATA transcription factor that is expressed in the MYOCARDIUM of developing heart and has been implicated in the differentiation of CARDIAC MYOCYTES. GATA4 is activated by PHOSPHORYLATION and regulates transcription of cardiac-specific genes.
The level of protein structure in which regular hydrogen-bond interactions within contiguous stretches of polypeptide chain give rise to alpha helices, beta strands (which align to form beta sheets) or other types of coils. This is the first folding level of protein conformation.
Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.
The downward displacement of the cuspal or pointed end of the trileaflet AORTIC VALVE causing misalignment of the cusps. Severe valve distortion can cause leakage and allow the backflow of blood from the ASCENDING AORTA back into the LEFT VENTRICLE, leading to aortic regurgitation.
An activating transcription factor that plays a key role in cellular responses to GENOTOXIC STRESS and OXIDATIVE STRESS.
A family of transcription factors characterized by the presence of highly conserved calcineurin- and DNA-binding domains. NFAT proteins are activated in the CYTOPLASM by the calcium-dependent phosphatase CALCINEURIN. They transduce calcium signals to the nucleus where they can interact with TRANSCRIPTION FACTOR AP-1 or NF-KAPPA B and initiate GENETIC TRANSCRIPTION of GENES involved in CELL DIFFERENTIATION and development. NFAT proteins stimulate T-CELL activation through the induction of IMMEDIATE-EARLY GENES such as INTERLEUKIN-2.
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Motifs in DNA- and RNA-binding proteins whose amino acids are folded into a single structural unit around a zinc atom. In the classic zinc finger, one zinc atom is bound to two cysteines and two histidines. In between the cysteines and histidines are 12 residues which form a DNA binding fingertip. By variations in the composition of the sequences in the fingertip and the number and spacing of tandem repeats of the motif, zinc fingers can form a large number of different sequence specific binding sites.
Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.
The first nucleotide of a transcribed DNA sequence where RNA polymerase (DNA-DIRECTED RNA POLYMERASE) begins synthesizing the RNA transcript.
Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.
A specificity protein transcription factor that regulates expression of a variety of genes including VASCULAR ENDOTHELIAL GROWTH FACTOR and CYCLIN-DEPENDENT KINASE INHIBITOR P27.
An electrophoretic technique for assaying the binding of one compound to another. Typically one compound is labeled to follow its mobility during electrophoresis. If the labeled compound is bound by the other compound, then the mobility of the labeled compound through the electrophoretic medium will be retarded.
A family of transcription factors that control EMBRYONIC DEVELOPMENT within a variety of cell lineages. They are characterized by a highly conserved paired DNA-binding domain that was first identified in DROSOPHILA segmentation genes.
Cis-acting DNA sequences which can increase transcription of genes. Enhancers can usually function in either orientation and at various distances from a promoter.
An RNA POLYMERASE II specific transcription factor. It plays a role in assembly of the pol II transcriptional preinitiation complex and has been implicated as a target of gene-specific transcriptional activators.
An activating transcription factor that regulates expression of a variety of GENES including C-JUN GENES; CYCLIN A; CYCLIN D1; and ACTIVATING TRANSCRIPTION FACTOR 3.
Nucleic acid sequences involved in regulating the expression of genes.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
A family of transcription factors that contain regions rich in basic residues, LEUCINE ZIPPER domains, and HELIX-LOOP-HELIX MOTIFS.
A DNA-dependent RNA polymerase present in bacterial, plant, and animal cells. It functions in the nucleoplasmic structure and transcribes DNA into RNA. It has different requirements for cations and salt than RNA polymerase I and is strongly inhibited by alpha-amanitin. EC 2.7.7.6.
An E2F transcription factor that interacts directly with RETINOBLASTOMA PROTEIN and CYCLIN A and activates GENETIC TRANSCRIPTION required for CELL CYCLE entry and DNA synthesis. E2F1 is involved in DNA REPAIR and APOPTOSIS.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Activating transcription factors of the MADS family which bind a specific sequence element (MEF2 element) in many muscle-specific genes and are involved in skeletal and cardiac myogenesis, neuronal differentiation and survival/apoptosis.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
A family of DNA-binding proteins that are primarily expressed in T-LYMPHOCYTES. They interact with BETA CATENIN and serve as transcriptional activators and repressors in a variety of developmental processes.
A GATA transcription factor that is found predominately in LYMPHOID CELL precursors and has been implicated in the CELL DIFFERENTIATION of HELPER T-CELLS. Haploinsufficiency of GATA3 is associated with HYPOPARATHYROIDISM; SENSORINEURAL HEARING LOSS; and renal anomalies syndrome.
A GATA transcription factor that is specifically expressed in hematopoietic lineages and plays an important role in the CELL DIFFERENTIATION of ERYTHROID CELLS and MEGAKARYOCYTES.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in fungi.
An essential GATA transcription factor that is expressed primarily in HEMATOPOIETIC STEM CELLS.
A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement.
The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.
Genetically engineered MUTAGENESIS at a specific site in the DNA molecule that introduces a base substitution, or an insertion or deletion.
A family of transcription factors that contain two ZINC FINGER MOTIFS and bind to the DNA sequence (A/T)GATA(A/G).
Enzymes that oxidize certain LUMINESCENT AGENTS to emit light (PHYSICAL LUMINESCENCE). The luciferases from different organisms have evolved differently so have different structures and substrates.
A basic helix-loop-helix leucine zipper transcription factor that regulates the CELL DIFFERENTIATION and development of a variety of cell types including MELANOCYTES; OSTEOCLASTS; and RETINAL PIGMENT EPITHELIUM. Mutations in MITF protein have been associated with OSTEOPETROSIS and WAARDENBURG SYNDROME.
The spatial arrangement of the atoms of a nucleic acid or polynucleotide that results in its characteristic 3-dimensional shape.
Proteins obtained from the species SACCHAROMYCES CEREVISIAE. The function of specific proteins from this organism are the subject of intense scientific interest and have been used to derive basic understanding of the functioning similar proteins in higher eukaryotes.
A cell line derived from cultured tumor cells.
A signal transducer and activator of transcription that mediates cellular responses to INTERFERONS. Stat1 interacts with P53 TUMOR SUPPRESSOR PROTEIN and regulates expression of GENES involved in growth control and APOPTOSIS.
Activating transcription factors were originally identified as DNA-BINDING PROTEINS that interact with early promoters from ADENOVIRUSES. They are a family of basic leucine zipper transcription factors that bind to the consensus site TGACGTCA of the cyclic AMP response element, and are closely related to CYCLIC AMP-RESPONSIVE DNA-BINDING PROTEIN.
The material of CHROMOSOMES. It is a complex of DNA; HISTONES; and nonhistone proteins (CHROMOSOMAL PROTEINS, NON-HISTONE) found within the nucleus of a cell.
Proteins prepared by recombinant DNA technology.
A subunit of NF-kappa B that is primarily responsible for its transactivation function. It contains a C-terminal transactivation domain and an N-terminal domain with homology to PROTO-ONCOGENE PROTEINS C-REL.
A family of basic helix-loop-helix transcription factors that control expression of a variety of GENES involved in CELL CYCLE regulation. E2F transcription factors typically form heterodimeric complexes with TRANSCRIPTION FACTOR DP1 or transcription factor DP2, and they have N-terminal DNA binding and dimerization domains. E2F transcription factors can act as mediators of transcriptional repression or transcriptional activation.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in plants.
Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
A sequence of amino acids in a polypeptide or of nucleotides in DNA or RNA that is similar across multiple species. A known set of conserved sequences is represented by a CONSENSUS SEQUENCE. AMINO ACID MOTIFS are often composed of conserved sequences.
A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population.
A transcription factor that takes part in WNT signaling pathway where it may play a role in the differentiation of KERATINOCYTES. The transcriptional activity of this protein is regulated via its interaction with BETA CATENIN.
A protein that has been shown to function as a calcium-regulated transcription factor as well as a substrate for depolarization-activated CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES. This protein functions to integrate both calcium and cAMP signals.
Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.
Theoretical representations that simulate the behavior or activity of genetic processes or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.
A GATA transcription factor that is expressed predominately in SMOOTH MUSCLE CELLS and regulates vascular smooth muscle CELL DIFFERENTIATION.
An activating transcription factor that regulates expression of a variety of genes including C-JUN GENES and TRANSFORMING GROWTH FACTOR BETA2.
An activating transcription factor that regulates the expression of a variety of GENES involved in amino acid metabolism and transport. It also interacts with HTLV-I transactivator protein.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
One of several general transcription factors that are specific for RNA POLYMERASE III. It is a zinc finger (ZINC FINGERS) protein and is required for transcription of 5S ribosomal genes.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
Proteins that originate from insect species belonging to the genus DROSOPHILA. The proteins from the most intensely studied species of Drosophila, DROSOPHILA MELANOGASTER, are the subject of much interest in the area of MORPHOGENESIS and development.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
The malignant stem cells of TERATOCARCINOMAS, which resemble pluripotent stem cells of the BLASTOCYST INNER CELL MASS. The EC cells can be grown in vitro, and experimentally induced to differentiate. They are used as a model system for studying early embryonic cell differentiation.
A conserved A-T rich sequence which is contained in promoters for RNA polymerase II. The segment is seven base pairs long and the nucleotides most commonly found are TATAAAA.
Proteins found in any species of bacterium.
A theoretical representative nucleotide or amino acid sequence in which each nucleotide or amino acid is the one which occurs most frequently at that site in the different sequences which occur in nature. The phrase also refers to an actual sequence which approximates the theoretical consensus. A known CONSERVED SEQUENCE set is represented by a consensus sequence. Commonly observed supersecondary protein structures (AMINO ACID MOTIFS) are often formed by conserved sequences.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
Transcription factors that were originally identified as site-specific DNA-binding proteins essential for DNA REPLICATION by ADENOVIRUSES. They play important roles in MAMMARY GLAND function and development.
Cellular DNA-binding proteins encoded by the c-jun genes (GENES, JUN). They are involved in growth-related transcriptional control. There appear to be three distinct functions: dimerization (with c-fos), DNA-binding, and transcriptional activation. Oncogenic transformation can take place by constitutive expression of c-jun.
A genus of gram-positive bacteria in the family Cellulomonadaceae.
A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
A family of transcription factors that share a unique DNA-binding domain. The name derives from viral oncogene-derived protein oncogene protein v-ets of the AVIAN ERYTHROBLASTOSIS VIRUS.
Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.
Enzymes that catalyze DNA template-directed extension of the 3'-end of an RNA strand one nucleotide at a time. They can initiate a chain de novo. In eukaryotes, three forms of the enzyme have been distinguished on the basis of sensitivity to alpha-amanitin, and the type of RNA synthesized. (From Enzyme Nomenclature, 1992).
Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria.
Small chromosomal proteins (approx 12-20 kD) possessing an open, unfolded structure and attached to the DNA in cell nuclei by ionic linkages. Classification into the various types (designated histone I, histone II, etc.) is based on the relative amounts of arginine and lysine in each.
A polynucleotide consisting essentially of chains with a repeating backbone of phosphate and ribose units to which nitrogenous bases are attached. RNA is unique among biological macromolecules in that it can encode genetic information, serve as an abundant structural component of cells, and also possesses catalytic activity. (Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
A class of proteins that were originally identified by their ability to bind the DNA sequence CCAAT. The typical CCAAT-enhancer binding protein forms dimers and consists of an activation domain, a DNA-binding basic region, and a leucine-rich dimerization domain (LEUCINE ZIPPERS). CCAAT-BINDING FACTOR is structurally distinct type of CCAAT-enhancer binding protein consisting of a trimer of three different subunits.
Proteins found in any species of fungus.
A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.
Proteins that originate from plants species belonging to the genus ARABIDOPSIS. The most intensely studied species of Arabidopsis, Arabidopsis thaliana, is commonly used in laboratory experiments.
Deletion of sequences of nucleic acids from the genetic material of an individual.
An RNA POLYMERASE II specific transcription factor. It may play a role in transcriptional activation of gene expression by interacting with the TATA-BOX BINDING PROTEIN component of TRANSCRIPTION FACTOR TFIID.
The process by which two molecules of the same chemical composition form a condensation product or polymer.
A SOXE transcription factor that plays a critical role in regulating CHONDROGENESIS; OSTEOGENESIS; and male sex determination. Loss of function of the SOX9 transcription factor due to genetic mutations is a cause of CAMPOMELIC DYSPLASIA.
A general transcription factor that is involved in basal GENETIC TRANSCRIPTION and NUCLEOTIDE EXCISION REPAIR. It consists of nine subunits including ATP-DEPENDENT DNA HELICASES; CYCLIN H; and XERODERMA PIGMENTOSUM GROUP D PROTEIN.
Commonly observed structural components of proteins formed by simple combinations of adjacent secondary structures. A commonly observed structure may be composed of a CONSERVED SEQUENCE which can be represented by a CONSENSUS SEQUENCE.
A plant genus of the family BRASSICACEAE that contains ARABIDOPSIS PROTEINS and MADS DOMAIN PROTEINS. The species A. thaliana is used for experiments in classical plant genetics as well as molecular genetic studies in plant physiology, biochemistry, and development.
A signal transducer and activator of transcription that mediates cellular responses to a variety of CYTOKINES. Stat5 activation is associated with transcription of CELL CYCLE regulators such as CYCLIN KINASE INHIBITOR P21 and anti-apoptotic genes such as BCL-2 GENES. Stat5 is constitutively activated in many patients with acute MYELOID LEUKEMIA.
A method for determining the sequence specificity of DNA-binding proteins. DNA footprinting utilizes a DNA damaging agent (either a chemical reagent or a nuclease) which cleaves DNA at every base pair. DNA cleavage is inhibited where the ligand binds to DNA. (from Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
A transcription factor that possesses DNA-binding and E2F-binding domains but lacks a transcriptional activation domain. It is a binding partner for E2F TRANSCRIPTION FACTORS and enhances the DNA binding and transactivation function of the DP-E2F complex.
Screening techniques first developed in yeast to identify genes encoding interacting proteins. Variations are used to evaluate interplay between proteins and other molecules. Two-hybrid techniques refer to analysis for protein-protein interactions, one-hybrid for DNA-protein interactions, three-hybrid interactions for RNA-protein interactions or ligand-based interactions. Reverse n-hybrid techniques refer to analysis for mutations or other small molecules that dissociate known interactions.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in enzyme synthesis.
The rate dynamics in chemical or physical systems.
Proteins containing a region of conserved sequence, about 200 amino acids long, which encodes a particular sequence specific DNA binding domain (the T-box domain). These proteins are transcription factors that control developmental pathways. The prototype of this family is the mouse Brachyury (or T) gene product.
The sequential correspondence of nucleotides in one nucleic acid molecule with those of another nucleic acid molecule. Sequence homology is an indication of the genetic relatedness of different organisms and gene function.
Transport proteins that carry specific substances in the blood or across cell membranes.
A genus of small, two-winged flies containing approximately 900 described species. These organisms are the most extensively studied of all genera from the standpoint of genetics and cytology.
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
Nucleotide sequences of a gene that are involved in the regulation of GENETIC TRANSCRIPTION.
Process of generating a genetic MUTATION. It may occur spontaneously or be induced by MUTAGENS.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
A ubiquitously expressed octamer transcription factor that regulates GENETIC TRANSCRIPTION of SMALL NUCLEAR RNA; IMMUNOGLOBULIN GENES; and HISTONE H2B genes.
A genetic rearrangement through loss of segments of DNA or RNA, bringing sequences which are normally separated into close proximity. This deletion may be detected using cytogenetic techniques and can also be inferred from the phenotype, indicating a deletion at one specific locus.
CELL LINES derived from the CV-1 cell line by transformation with a replication origin defective mutant of SV40 VIRUS, which codes for wild type large T antigen (ANTIGENS, POLYOMAVIRUS TRANSFORMING). They are used for transfection and cloning. (The CV-1 cell line was derived from the kidney of an adult male African green monkey (CERCOPITHECUS AETHIOPS).)
Detection of RNA that has been electrophoretically separated and immobilized by blotting on nitrocellulose or other type of paper or nylon membrane followed by hybridization with labeled NUCLEIC ACID PROBES.
A general transcription factor that plays a major role in the activation of eukaryotic genes transcribed by RNA POLYMERASES. It binds specifically to the TATA BOX promoter element, which lies close to the position of transcription initiation in RNA transcribed by RNA POLYMERASE II. Although considered a principal component of TRANSCRIPTION FACTOR TFIID it also takes part in general transcription factor complexes involved in RNA POLYMERASE I and RNA POLYMERASE III transcription.
Proteins found in plants (flowers, herbs, shrubs, trees, etc.). The concept does not include proteins found in vegetables for which VEGETABLE PROTEINS is available.
A group of transcription factors that were originally described as being specific to ERYTHROID CELLS.
Interacting DNA-encoded regulatory subsystems in the GENOME that coordinate input from activator and repressor TRANSCRIPTION FACTORS during development, cell differentiation, or in response to environmental cues. The networks function to ultimately specify expression of particular sets of GENES for specific conditions, times, or locations.
A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.
The developmental history of specific differentiated cell types as traced back to the original STEM CELLS in the embryo.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.
A family of low-molecular weight, non-histone proteins found in chromatin.
An enzyme capable of hydrolyzing highly polymerized DNA by splitting phosphodiester linkages, preferentially adjacent to a pyrimidine nucleotide. This catalyzes endonucleolytic cleavage of DNA yielding 5'-phosphodi- and oligonucleotide end-products. The enzyme has a preference for double-stranded DNA.
Factors that bind to RNA POLYMERASE III and aid in transcription. They include the assembly factors TFIIIA and TFIIIC and the initiation factor TFIIIB. All combine to form a preinitiation complex at the promotor that directs the binding of RNA POLYMERASE III.
A heterotetrameric transcription factor composed of two distinct proteins. Its name refers to the fact it binds to DNA sequences rich in GUANINE and ADENINE. GA-binding protein integrates a variety of SIGNAL TRANSDUCTION PATHWAYS and regulates expression of GENES involved in CELL CYCLE control, PROTEIN BIOSYNTHESIS, and cellular METABOLISM.
Elements of limited time intervals, contributing to particular results or situations.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
A multisubunit eukaryotic initiation factor that contains at least 8 distinct polypeptides. It plays a role in recycling of ribosomal subunits to the site of transcription initiation by promoting the dissociation of non-translating ribosomal subunits. It also is involved in promoting the binding of a ternary complex of EUKARYOTIC INITIATION FACTOR-2; GTP; and INITIATOR TRNA to the 40S ribosomal subunit.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
An ets proto-oncogene expressed primarily in adult LYMPHOID TISSUE; BRAIN; and VASCULAR ENDOTHELIAL CELLS.
Use of restriction endonucleases to analyze and generate a physical map of genomes, genes, or other segments of DNA.
A transcription factor that takes part in WNT signaling pathway. The activity of the protein is regulated via its interaction with BETA CATENIN. Transcription factor 7-like 2 protein plays an important role in the embryogenesis of the PANCREAS and ISLET CELLS.
Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.
A group of deoxyribonucleotides (up to 12) in which the phosphate residues of each deoxyribonucleotide act as bridges in forming diester linkages between the deoxyribose moieties.
The biosynthesis of DNA carried out on a template of RNA.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.
An enzyme that catalyzes the acetylation of chloramphenicol to yield chloramphenicol 3-acetate. Since chloramphenicol 3-acetate does not bind to bacterial ribosomes and is not an inhibitor of peptidyltransferase, the enzyme is responsible for the naturally occurring chloramphenicol resistance in bacteria. The enzyme, for which variants are known, is found in both gram-negative and gram-positive bacteria. EC 2.3.1.28.
A basic helix-loop-helix transcription factor that was originally identified in DROSOPHILA as essential for proper gastrulation and MESODERM formation. It plays an important role in EMBRYONIC DEVELOPMENT and CELL DIFFERENTIATION of MUSCLE CELLS, and is found in a wide variety of organisms.
Any of the processes by which cytoplasmic factors influence the differential control of gene action in viruses.
Much like CYCLE, the ARNTL proteins have a basic helix-loop-helix and a PAS domain containing transcription factors responsible ... The cyc gene is located on the left arm of chromosome 3 and codes for a transcription factor containing a basic helix-loop- ... and transcription factor activity. Other non-arthropods containing the functional ortholog of the Drosophila cycle ARNTL and ... repressing CYC-CLK dependent transcription. Thus, CLK and CYC act as positive factors and PER and TIM as negative factors. CYC ...
BMAL1 encodes a transcription factor with a basic helix-loop-helix (bHLH) and two PAS domains. The human Arntl gene has a ... is a paralog of Arntl (Bmal1) that encodes for a basic helix-loop-helix PAS domain transcription factor. It, too, has been ... "Mitogen-activated protein kinase phosphorylates and negatively regulates basic helix-loop-helix-PAS transcription factor BMAL1 ... Ooe N, Saito K, Mikami N, Nakatuka I, Kaneko H (January 2004). "Identification of a novel basic helix-loop-helix-PAS factor, ...
... studying transcription factors with basic helix-loop-helix (BHLH) and PAS protein domains. Hogenesh was mentored by Chris ... better known as BMAL1 or ARNTL, revealed in 1998 that its role as a partner of the bHLH-PAS transcription factor CLOCK was ... when he discovered five transcription factors in the basic helix-loop-helix-PAS (bHLH-PAS) domain superfamily during his thesis ... BMAL1 and CLOCK are now the two most well recognized bHLH-PAS domain transcription factors. Later work revealed that Bmal1 is ...
PDOC00038 in PROSITE Basic+Helix-Loop-Helix+Transcription+Factors at the US National Library of Medicine Medical Subject ... ARNTL; ARNTL2; ASCL1; ASCL2; ASCL3; ASCL4; ATOH1; ATOH7; ATOH8; BHLHB2; BHLHB3; BHLHB4; BHLHB5; BHLHB8; CLOCK; EPAS1; FERD3L; ... "Crystal structure of transcription factor E47: E-box recognition by a basic region helix-loop-helix dimer". Genes Dev. 8 (8): ... Wang GL, Jiang BH, Rue EA, Semenza GL (June 1995). "Hypoxia-inducible factor 1 is a basic helix-loop-helix-PAS heterodimer ...
Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors". The Journal of Biological Chemistry. ... EPAS1 has been shown to interact with aryl hydrocarbon receptor nuclear translocator and ARNTL. GRCh38: Ensembl release 89: ... "The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors". ... "The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors". ...
1.2) Basic helix-loop-helix (bHLH). *ATOH1. *AhR. *AHRR. *ARNT. *ASCL1. *BHLH *2 ... the domain in winged-helix transcription factors (see Regulation of gene expression) has four helices and a two-strand beta- ... Winged-Helix+Transcription+Factors at the US National Library of Medicine Medical Subject Headings (MeSH) ... Retrieved from "https://en.wikipedia.org/w/index.php?title=Winged-helix_transcription_factors&oldid=730546101" ...
1.2) Basic helix-loop-helix (bHLH). *ATOH1. *AhR. *AHRR. *ARNT. *ASCL1. *BHLH *2 ... Zinc finger transcription factors or ZF-TFs, are transcription factors composed of a zinc finger-binding domain and any of a ... Zinc finger transcription factor. From Wikipedia, the free encyclopedia. (Redirected from Zinc finger protein transcription ... genes in order to control the transcription of all these genes with a single transcription factor. Also, it is possible to ...
The NPAS2 protein is a member of the basic helix-loop-helix (bHLH)-PAS transcription factor family and is expressed in the SCN ... ARNTL, and CLOCK polymorphisms. These genes may influence seasonal variations through metabolic factors such as body weight and ... "The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors". ... "Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin ...
"The basic helix-loop-helix-PAS protein MOP9 is a brain-specific heterodimeric partner of circadian and hypoxia factors". The ... Hung MS, Avner P, Rogner UC (September 2006). "Identification of the transcription factor ARNTL2 as a candidate gene for the ... Recent work suggest that this interaction may be in concert with ARNTL/CLOCK heterodimeric complexes. Arntl (Bmal1) GRCh38: ... "cDNA cloning of a novel bHLH-PAS transcription factor superfamily gene, BMAL2: its mRNA expression, subcellular distribution, ...
"Crystal structure of transcription factor E47: E-box recognition by a basic region helix-loop-helix dimer". Genes Dev. 8 (8): ... There are several proteins that bind to the E-box and affect gene transcription. The CLOCK-ARNTL (BMAL1) complex is an integral ... "Serine/Threonine kinases 3pK and MAPK-activated protein kinase 2 interact with the basic helix-loop-helix transcription factor ... is recognized and bound by transcription factors to initiate gene transcription. Once the transcription factors bind to the ...
The aryl hydrocarbon receptor is a member of the family of basic helix-loop-helix transcription factors. AHR binds several ... In addition to the protein interactions mentioned above, AhR has also been shown to interact with: AIP, ARNTL, CCNT1, ESR1, ... which is involved in the binding of the transcription factor to DNA. The second is the helix-loop-helix (HLH) region, which ... The AhR protein contains several domains critical for function and is classified as a member of the basic helix-loop-helix/Per- ...
"Entrez Gene: HIF1A hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)". Wang GL, Jiang BH ... HIF1A has been shown to interact with: ARNTL, ARNT, CREBB, EP300, HIF1AN, Mdm2, NR4A, P53, PSMA7, STAT3, UBC, VH and VHL. GR ( ... Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors". The Journal of Biological Chemistry. ... two basic loop helix/PAS domain transcription factors involved in adaptative responses to hypoxic stresses". Biochemical and ...
1) Basic domains. (1.1) Basic leucine zipper (bZIP). *Activating transcription factor *AATF ... 1.2) Basic helix-loop-helix (bHLH). *ATOH1. *AhR. *AHRR. *ARNT. *ASCL1. *BHLH *2 ... transcription factor complex. • nuclear transcription factor complex. Biological process. • intracellular signal transduction. ... RNA polymerase II transcription factor binding. • transcription factor activity, sequence-specific DNA binding. • mitogen- ...
1) Basic domains. (1.1) Basic leucine zipper (bZIP). *Activating transcription factor *AATF ... 1.2) Basic helix-loop-helix (bHLH). *ATOH1. *AhR. *AHRR. *ARNT. *ASCL1. *BHLH *2 ... M type MADS family at PlantTFDB: Plant Transcription Factor Database. *MIKC type MADS family at PlantTFDB: Plant Transcription ... Gramzow L, Ritz MS, Theissen G (April 2010). "On the origin of MADS-domain transcription factors". Trends in Genetics. 26 (4): ...
1.2) Basic helix-loop-helix (bHLH). *ATOH1. *AhR. *AHRR. *ARNT. *ASCL1. *BHLH *2 ... A sigma factorfactor) is a protein needed only for initiation of transcription.[1] It is a bacterial transcription ... Sigma factors in E. coli:. *σ70(RpoD) - σA - the "housekeeping" sigma factor or also called as primary sigma factor, ... It is homologous to archaeal transcription factor B and to eukaryotic TFIIB.[2] The specific sigma factor used to initiate ...
1) Basic domains. (1.1) Basic leucine zipper (bZIP). *Activating transcription factor *AATF ... 1.2) Basic helix-loop-helix (bHLH). *ATOH1. *AhR. *AHRR. *ARNT. *ASCL1. *BHLH *2 ... transcription factor activity, sequence-specific DNA binding. • RNA polymerase II transcription factor activity, sequence- ... "Pituitary homeobox factor 1, a novel transcription factor in the adrenal regulating steroid 11beta-hydroxylase". Hormone and ...
1) Basic domains. (1.1) Basic leucine zipper (bZIP). *Activating transcription factor *AATF ... 1.2) Basic helix-loop-helix (bHLH). *ATOH1. *AhR. *AHRR. *ARNT. *ASCL1. *BHLH *2 ... Interferon regulatory factor 7, also known as IRF7, is a member of the interferon regulatory factor family of transcription ... transcription regulatory region DNA binding. • RNA polymerase II transcription factor activity, sequence-specific DNA binding. ...
1.2) Basic helix-loop-helix (bHLH). .mw-parser-output .nobold{font-weight:normal}. bHLH-PAS. *AhR ... transcription regulatory region sequence-specific DNA binding. • metal ion binding. • transcription factor activity, RNA ... EGR-1 is a mammalian transcription factor. It was also named Krox-24, TIS8, and ZENK. It was originally discovered in mice. ... EGR-1 is an important transcription factor in memory formation. It has an essential role in brain neuron epigenetic ...
1) Basic domains. (1.1) Basic leucine zipper (bZIP). *Activating transcription factor *AATF ... 1.2) Basic helix-loop-helix (bHLH). *ATOH1. *AhR. *AHRR. *ARNT. *ASCL1. *BHLH *2 ... transcription factor binding. • protein domain specific binding. • RNA polymerase II transcription factor activity, sequence- ... Hepatocyte nuclear factor 3-gamma (HNF-3G), also known as forkhead box protein A3 (FOXA3) or transcription factor 3G (TCF-3G) ...
1) Basic domains. (1.1) Basic leucine zipper (bZIP). *Activating transcription factor *AATF ... 1.2) Basic helix-loop-helix (bHLH). *ATOH1. *AhR. *AHRR. *ARNT. *ASCL1. *BHLH *2 ... transcription factor activity, sequence-specific DNA binding. • DNA binding. • transcription cofactor activity. • histone ... regulation of transcription from RNA polymerase II promoter. • regulation of transcription, DNA-templated. • transcription, DNA ...
1.2) Basic helix-loop-helix (bHLH). .mw-parser-output .nobold{font-weight:normal}. bHLH-PAS. *AhR ... 0001204 DNA-binding transcription factor activity. • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor ... regulation of transcription, DNA-templated. • transcription, DNA-templated. • regulation of transcription from RNA polymerase ... "Human KLF17 is a new member of the Sp/KLF family of transcription factors". Genomics. 87 (4): 474-82. doi:10.1016/j.ygeno. ...
It belongs to a family of basic helix-loop-helix (bHLH) transcription factors involved in the determination of neural precursor ... transcription factor activity, sequence-specific DNA binding. • transcription coactivator activity. • transcriptional activator ... positive regulation of sequence-specific DNA binding transcription factor activity. • negative regulation of transcription from ... transcription from RNA polymerase II promoter. • transcription, DNA-templated. • nervous system development. • regulation of ...
1) Basic domains. (1.1) Basic leucine zipper (bZIP). *Activating transcription factor *AATF ... 1.2) Basic helix-loop-helix (bHLH). *ATOH1. *AhR. *AHRR. *ARNT. *ASCL1. *BHLH *2 ... transcription factor activity, sequence-specific DNA binding. • RNA polymerase II regulatory region sequence-specific DNA ... The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in ...
1) Basic domains. (1.1) Basic leucine zipper (bZIP). *Activating transcription factor *AATF ... 1.2) Basic helix-loop-helix (bHLH). *ATOH1. *AhR. *AHRR. *ARNT. *ASCL1. *BHLH *2 ... RNA polymerase II transcription factor activity, sequence-specific DNA binding. Cellular component. • transcription factor ... Forkhead box protein E3 (FOXE3) also known as forkhead-related transcription factor 8 (FREAC-8) is a protein that in humans is ...
1.2) Basic helix-loop-helix (bHLH). .mw-parser-output .nobold{font-weight:normal}. bHLH-PAS. *AhR ... transcription factor activity, sequence-specific DNA binding transcription factor recruiting. • GO:0001948 protein binding. • ... transcription, DNA-templated. • negative regulation of sequence-specific DNA binding transcription factor activity. • negative ... negative regulation of transcription, DNA-templated. • negative regulation of NF-kappaB transcription factor activity. • ...
1) Basic domains. (1.1) Basic leucine zipper (bZIP). *Activating transcription factor *AATF ... 1.2) Basic helix-loop-helix (bHLH). *ATOH1. *AhR. *AHRR. *ARNT. *ASCL1. *BHLH *2 ... OSR1, ODD, odd-skipped related transcription factor 1, odd-skipped related transciption factor 1. ... Protein odd-skipped-related 1 is a transcription factor that in humans is encoded by the OSR1 gene.[5][6][7] The OSR1 and OSR2 ...
Fujiwara T (June 2017). "GATA Transcription Factors: Basic Principles and Related Human Disorders". The Tohoku Journal of ... transcriptional activation by promoter-enhancer looping. • cell-cell signaling. • embryonic hemopoiesis. • cell development. • ... transcription factor regulating cell cycle progression),[25] TAL1 (a transcription factor),[26] FOG2 (a transcription factor ... 1.6) Basic helix-span-helix (bHSH). *AP-2 *α. *β. *γ. *δ ... globin transcription factor 1)".. *^ a b c Da Costa L, ...
1) Basic domains. (1.1) Basic leucine zipper (bZIP). *Activating transcription factor *AATF ... 1.2) Basic helix-loop-helix (bHLH). *ATOH1. *AhR. *AHRR. *ARNT. *ASCL1. *BHLH *2 ... transcription regulatory region DNA binding. • identical protein binding. • RNA polymerase II transcription factor activity, ... regulation of transcription from RNA polymerase II promoter. • transcription from RNA polymerase II promoter. • transcription, ...
1) Basic domains. (1.1) Basic leucine zipper (bZIP). *Activating transcription factor *AATF ... 1.2) Basic helix-loop-helix (bHLH). *ATOH1. *AhR. *AHRR. *ARNT. *ASCL1. *BHLH *2 ... and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGF)". Genomics. 13 (2 ... and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGF)". Genomics. 13 (2 ...
1) Basic domains. (1.1) Basic leucine zipper (bZIP). *Activating transcription factor *AATF ... 1.2) Basic helix-loop-helix (bHLH). *ATOH1. *AhR. *AHRR. *ARNT. *ASCL1. *BHLH *2 ... RNA polymerase II transcription factor activity, sequence-specific DNA binding. • transcription factor activity, sequence- ... transcription factor binding. • core promoter proximal region sequence-specific DNA binding. • protein binding. • transcription ...
1.3)bHLH-ZIP(英语:Basic helix-loop-helix leucine zipper transcription factors) ... ATOH1 · AhR · AHRR · ARNT · ASCL1 · BHLHB2 · BMAL(ARNTL、ARNTL2) · CLOCK · EPAS1 · HAND(1、2) · HES(5、6) · HEY(1、2、L) · HES1 · ... 转录激活因子(英语:Activating transcription factor)(AATF(英语:Apoptosis-antagonizing transcription factor)、1、2、3、4、5、6、7) · AP-1(c-Fos、 ... sequence-specific enhancer binding RNA polymerase II transcription factor activity. · transcription factor binding. · zinc ion ...
SREBPs belong to the basic-helix-loop-helix leucine zipper class of transcription factors.[2] Unactivated SREBPs are attached ... Gasic GP (Apr 1994). "Basic-helix-loop-helix transcription factor and sterol sensor in a single membrane-bound molecule". Cell ... a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene". Cell ... SREBPs have a structure similar to E-box-binding helix-loop-helix (HLH) proteins. However, in contrast to E-box-binding HLH ...
1) Basic domains. (1.1) Basic leucine zipper (bZIP). *Activating transcription factor *AATF ... 1.2) Basic helix-loop-helix (bHLH). *ATOH1. *AhR. *AHRR. *ARNT. *ASCL1. *BHLH *2 ... transcription corepressor activity. • transcription factor activity, sequence-specific DNA binding. • transcription coactivator ... RNA polymerase II transcription factor activity, sequence-specific DNA binding. Cellular component. • nuclear euchromatin. • ...
1) Basic domains. (1.1) Basic leucine zipper (bZIP). *Activating transcription factor *AATF ... 1mse: SOLUTION STRUCTURE OF A SPECIFIC DNA COMPLEX OF THE MYB DNA-BINDING DOMAIN WITH COOPERATIVE RECOGNITION HELICES ... transcription factor activity, RNA polymerase II transcription factor recruiting. • RNA polymerase II transcription factor ... Arabidospsis thaliana MYB family at Database of Arabidopsis Transcription Factors (DATF). This article incorporates text from ...
1) Basic domains. (1.1) Basic leucine zipper (bZIP). *Activating transcription factor *AATF ... 1.2) Basic helix-loop-helix (bHLH). *ATOH1. *AhR. *AHRR. *ARNT. *ASCL1. *BHLH *2 ... transcription factor activity, sequence-specific DNA binding. • transcription factor binding. • RNA polymerase II core promoter ... Hepatocyte nuclear factor 3-beta (HNF-3B), also known as forkhead box protein A2 (FOXA2) or transcription factor 3B (TCF-3B) is ...
The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is ... "The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex ... Dai YS, Cserjesi P (April 2002). "The basic helix-loop-helix factor, HAND2, functions as a transcriptional activator by binding ... transcription factor binding. • activating transcription factor binding. • E-box binding. • protein binding. • protein ...
1) Basic domains. (1.1) Basic leucine zipper (bZIP). *Activating transcription factor *AATF ... 1.2) Basic helix-loop-helix (bHLH). *ATOH1. *AhR. *AHRR. *ARNT. *ASCL1. *BHLH *2 ... transcription factor activity, sequence-specific DNA binding. • sequence-specific DNA binding. • transcription factor binding. ... repressing transcription factor binding. • RNA polymerase II transcription factor activity, sequence-specific DNA binding. ...
1.2) Basic helix-loop-helix (bHLH). .mw-parser-output .nobold{font-weight:normal}. Group A. *AS-C *ASCL1 ... 0001204 DNA-binding transcription factor activity. • 5'-deoxyribose-5-phosphate lyase activity. • transcription factor binding ... "Enhancement of serum-response factor-dependent transcription and DNA binding by the architectural transcription factor HMG-I(Y ... 0001201 DNA-binding transcription factor activity, RNA polymerase II-specific. • GO:0001105 transcription coactivator activity ...
... domain but not a basic domain. Members of the ID family inhibit the functions of basic helix-loop-helix transcription factors ... "Differential interactions of Id proteins with basic-helix-loop-helix transcription factors". J. Biol. Chem. 272 (32): 19785-93 ... "Differential interactions of Id proteins with basic-helix-loop-helix transcription factors". J. Biol. Chem. 272 (32): 19785-93 ... "Id Helix-Loop-Helix Proteins Antagonize Pax Transcription Factor Activity by Inhibiting DNA Binding". Mol. Cell. Biol. 21 (2): ...
1) Basic domains. (1.1) Basic leucine zipper (bZIP). *Activating transcription factor *AATF ... 1.2) Basic helix-loop-helix (bHLH). *ATOH1. *AhR. *AHRR. *ARNT. *ASCL1. *BHLH *2 ... MTF1, MTF-1, ZRF, metal-regulatory transcription factor 1, metal regulatory transcription factor 1. ... transcription factor activity, sequence-specific DNA binding. • transcription coactivator activity. • transcriptional activator ...
1.2) Basic helix-loop-helix (bHLH). .mw-parser-output .nobold{font-weight:normal}. bHLH-PAS. *AhR ... The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in ... positive regulation of transcription from RNA polymerase II promoter. • transcription, DNA-templated. • transcription from RNA ... GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific. ...
1) Basic domains. (1.1) Basic leucine zipper (bZIP). *Activating transcription factor *AATF ... 1.2) Basic helix-loop-helix (bHLH). *ATOH1. *AhR. *AHRR. *ARNT. *ASCL1. *BHLH *2 ... transcription corepressor activity. • metal ion binding. • nucleic acid binding. • RNA polymerase II transcription factor ... DC-SCRIPT is able to repress ER and PR mediated transcription, whereas it can activate transcription mediated by RAR and PPAR. ...
1) Basic domains. (1.1) Basic leucine zipper (bZIP). *Activating transcription factor *AATF ... 1.2) Basic helix-loop-helix (bHLH). *ATOH1. *AhR. *AHRR. *ARNT. *ASCL1. *BHLH *2 ... regulation of transcription, DNA-templated. • transcription, DNA-templated. • DNA geometric change. • negative regulation of B ...
1) Basic domains. (1.1) Basic leucine zipper (bZIP). *Activating transcription factor *AATF ... 1.2) Basic helix-loop-helix (bHLH). *ATOH1. *AhR. *AHRR. *ARNT. *ASCL1. *BHLH *2 ...
1) Basic domains. (1.1) Basic leucine zipper (bZIP). *Activating transcription factor *AATF ... 1.2) Basic helix-loop-helix (bHLH). *ATOH1. *AhR. *AHRR. *ARNT. *ASCL1. *BHLH *2 ... regulation of transcription, DNA-templated. • transcription, DNA-templated. • oogenesis. • regulation of transcription from RNA ...
1) Basic domains. (1.1) Basic leucine zipper (bZIP). *Activating transcription factor *AATF ... 1.2) Basic helix-loop-helix (bHLH). *ATOH1. *AhR. *AHRR. *ARNT. *ASCL1. *BHLH *2 ... regulation of transcription, DNA-templated. • transcription, DNA-templated. • regulation of transcription from RNA polymerase ... transcription factor activity, sequence-specific DNA binding. • DNA binding. • metal ion binding. • nucleic acid binding. • RNA ...
1) Basic domains. (1.1) Basic leucine zipper (bZIP). *Activating transcription factor *AATF ... 1.2) Basic helix-loop-helix (bHLH). *ATOH1. *AhR. *AHRR. *ARNT. *ASCL1. *BHLH *2 ... transcription, DNA-templated. • positive regulation of transcription, DNA-templated. • brain development. • negative regulation ... regulation of transcription, DNA-templated. • histone H3-K27 demethylation. • histone H3-K9 demethylation. • histone H4-K20 ...
We show that cry transcription is under circadian regulati … ... ARNTL Transcription Factors * Basic Helix-Loop-Helix ... We show that cry transcription is under circadian regulation, influenced by the Drosophila clock genes period, timeless, Clock ... ARNTL Transcription Factors * Animals * Animals, Genetically Modified * Basic Helix-Loop-Helix Transcription Factors ...
CLOCK and BMAL1 are bHLH-PAS-containing transcription factors that bind to E-box elements and are indispensable for expression ... ARNTL Transcription Factors * ARNTL protein, human * Arntl protein, mouse * Basic Helix-Loop-Helix Transcription Factors ... Basic Helix-Loop-Helix Transcription Factors / chemistry * Basic Helix-Loop-Helix Transcription Factors / genetics ... CLOCK and BMAL1 are bHLH-PAS-containing transcription factors that bind to E-box elements and are indispensable for expression ...
0 (ARNTL Transcription Factors); 0 (Arntl protein, mouse); 0 (Basic Helix-Loop-Helix Transcription Factors); 0 (Membrane ... Fatores de Transcri o ARNTL/gen tica. Animais. Apoptose. Fatores de Transcri o H lice-Al a-H lice B sicos/gen tica. Prote nas ...
BMAL1 encodes a transcription factor with a basic helix-loop-helix (bHLH) and two PAS domains. The human Arntl gene has a ... is a paralog of Arntl (Bmal1) that encodes for a basic helix-loop-helix PAS domain transcription factor. It, too, has been ... "Mitogen-activated protein kinase phosphorylates and negatively regulates basic helix-loop-helix-PAS transcription factor BMAL1 ... Ooe N, Saito K, Mikami N, Nakatuka I, Kaneko H (January 2004). "Identification of a novel basic helix-loop-helix-PAS factor, ...
... basic helix-loop-helix family member e40; TCF7: transcription factor 7 (T-cell specific, HMG-box); NPAS2: neuronal PAS domain ... The ARNTL heterodimers also induce another regulatory loop that activates RORA & B and subsequent transcription of ARNTL. Many ... The primary transcription/translation feedback loop of the pathway includes ARNTL, which forms a heterodimer complex with ... Then PER and CRY form a negative feedback loop that represses their own transcription by acting on the heterodimer complex [37 ...
... encodes for a member of the basic helix-loop-helix PAS class of transcription factors [49]. When dimerized with ARNTL, NPAS2 ... putative protein belongs to the basic helix-loop-helix PAS family of transcription factors and forms heterodimers with ARNTL ( ... ARNTL-CLOCK or ARNTL-NPAS2 heterodimers promote the transcription of RORA, which in turn activates the transcription of ARNTL. ... PER genes control their own transcription by directly repressing ARNTL heterodimers, their activators [49]. Moreover, it has ...
... we found that the Clock gene encodes a novel member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. ... The CLOCK protein acts as a heterodimeric transcription factor with a partner known as BMAL1 (ARNTL). ... CLOCK and BMAL1 belong to the bHLH-PAS family of transcription factors, which participate in a wide array of functions ... time-dependent pattern of core circadian transcription factor binding, RNA polymerase II (RNAPII) recruitment, RNA expression, ...
The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone ... Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the ... The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone ... Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the ...
Much like CYCLE, the ARNTL proteins have a basic helix-loop-helix and a PAS domain containing transcription factors responsible ... The cyc gene is located on the left arm of chromosome 3 and codes for a transcription factor containing a basic helix-loop- ... and transcription factor activity. Other non-arthropods containing the functional ortholog of the Drosophila cycle ARNTL and ... repressing CYC-CLK dependent transcription. Thus, CLK and CYC act as positive factors and PER and TIM as negative factors. CYC ...
... was thought to be the primary determinant of the feedback loop that regulates Bmal1 transcription. Results reported by Sato et ... This finding defines the second feedback loop in mammals. ... same promoter element drive the rhythm in Bmal1 transcription. ... The circadian clock mechanism in mammals involves two interlocking transcriptional feedback loops. Rev-erb alpha, through its ... ARNTL Transcription Factors; Animals; Basic Helix-Loop-Helix Transcription Factors; Biological Clocks; Humans; Nuclear Receptor ...
... transcription factors that regulate myogenesis: MyoD, Myf5, myogenin, ... Myogenic regulatory factors Myogenic regulatory factors are basic-helix-loop-helix (bHLH) ... 1.2) Basic helix-loop-helix (bHLH). ATOH1 • AhR • AHRR • ARNT • ASCL1 • BMAL (ARNTL, ARNTL2) • CLOCK • HIF (1A, 3A) • Myogenic ... Myogenic regulatory factors are basic-helix-loop-helix (bHLH) transcription factors that regulate myogenesis: MyoD, Myf5, ...
1.2) Basic helix-loop-helix (bHLH). ATOH1 • AhR • AHRR • ARNT • ASCL1 • BMAL (ARNTL, ARNTL2) • CLOCK • HIF (1A, 3A) • Myogenic ... Transcription factors and intracellular receptors. (1) Basic domains. (1.1) Basic leucine zipper (bZIP). Activating ... transcription factor activity. • glucocorticoid receptor activity. • steroid binding. • protein binding. • zinc ion binding. • ... 3) Helix-turn-helix. domains. (3.1) Homeo domain. ARX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6 ...
Basic helix-loop-helix (bHLH) Ubiquitous (class A) factors Myogenic transcription factors ... K02296 ARNTL; aryl hydrocarbon receptor nuclear translocator-like protein 1 K02296 ARNTL; aryl hydrocarbon receptor nuclear ... Transcription Factors - Scleropages formosus (Asian bonytongue). [ Brite menu , Download htext , Download json , Help ] ... hypoxia-inducible factor 1 alpha K08268 HIF1A; hypoxia-inducible factor 1 alpha K09095 HIF2A; hypoxia-inducible factor 2 alpha ...
CLOCK-ARNTL/BMAL1,ARNTL2/BMAL2 heterodimer by competing for the binding to E-box elements (5-CACGTG-3) found within the ... DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are ... Acts as the negative limb of a novel autoregulatory feedback loop ( ... "Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1.". ...
This gene encodes a basic helix-loop-helix (bHLH) transcription factor that plays an important role in embryonic development. ... Represses the activity of the circadian transcriptional activator: NPAS2-ARNTL/BMAL1 heterodimer (By similarity). ... negative regulation of sequence-specific DNA binding transcription factor activity 62 negative regulation of DNA damage ... negative regulation of transcription from RNA polymerase II promoter 683 negative regulation of transcription, DNA-templated ...
Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the ... Contains 1 bHLH (basic helix-loop-helix) domain.. Contains 1 PAC (PAS-associated C-terminal) domain.. Contains 2 PAS (PER-ARNT- ... which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. ARNTL/BMAL1 ... Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. The NPAS2-ARNTL/BMAL1 ...
ARNTL Transcription Factors. *Adcyap1 protein, mouse. *Arntl protein, mouse. *Basic Helix-Loop-Helix Transcription Factors ...
ARNTL Transcription Factors. *Arntl protein, mouse. *Basic Helix-Loop-Helix Transcription Factors ... Basic Helix-Loop-Helix Transcription Factors/genetics. *Basic Helix-Loop-Helix Transcription Factors/metabolism ...
1.2) Basic helix-loop-helix (bHLH). ATOH1 • AhR • AHRR • ARNT • ASCL1 • BMAL (ARNTL, ARNTL2) • CLOCK • HIF (1A, 3A) • Myogenic ... Transcription factors and intracellular receptors. (1) Basic domains. (1.1) Basic leucine zipper (bZIP). Activating ... In the nucleus the complex acts as transcription factors, augmenting or suppressing transcription of particular genes by its ... 3) Helix-turn-helix. domains. (3.1) Homeo domain. ARX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6 ...
1.2) Basic helix-loop-helix (bHLH). ATOH1 • AhR • AHRR • ARNT • ASCL1 • BMAL (ARNTL, ARNTL2) • CLOCK • HIF (1A, 3A) • Myogenic ... Transcription factors and intracellular receptors. (1) Basic domains. (1.1) Basic leucine zipper (bZIP). Activating ... 3) Helix-turn-helix. domains. (3.1) Homeo domain. ARX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6 ... General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH: 1, 2) • GLI-Krüppel family (1, 2, 3, YY1) • KLF (2, 4 ...
Compare and order ARNTL ELISA试剂盒. View citations, images, detection ranges, sensitivity, prices and more. Recommended products ... basic-helix-loop-helix-PAS orphan MOP3 , basic-helix-loop-helix-PAS protein MOP3 , brain and muscle ARNT-like 1 , class E basic ... bHLH-PAS transcription factor BMAL1 , cBMAL1 , clock protein , aryl hydrocarbon receptor nuclear translocator-like , Brain and ... ARNTL Antigen Profile Antigen Summary The protein encoded by this gene is a basic helix-loop-helix protein that forms a ...
The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone ... Per and Cry proteins heterodimerize and repress their own transcription by interacting in a feedback loop with Clock/Arntl ... The encoded protein forms a heterodimer with Arntl (Bmal1) that binds E-box enhancer elements upstream of Period (Per1, Per2, ... Per3) and Cryptochrome (Cry1, Cry2) genes and activates transcription of these genes. ...
The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone ... Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the ... PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL ... which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. Regulates the ...
ARNTL Transcription Factors [D12.776.260.103.249] ARNTL Transcription Factors * Basic Helix Loop Helix Leucine Zipper ... Basic Helix Loop Helix Leucine Zipper Transcription Factors [D12.776.930.125.500] + Basic Helix Loop Helix Leucine Zipper ... Basic Helix Loop Helix Transcription Factors [D12.776.260.103] Basic Helix Loop Helix Transcription Factors ... Basic Helix Loop Helix Transcription Factors [D12.776.930.125] Basic Helix Loop Helix Transcription Factors ...
Human NPAS2 is a basic-helix-loop-helix (BHLH) transcription factor with two N-terminal PAS domains that forms a hetero-dimeric ... complex with BMAL1/ARNTL to regulate the transcription of key circadian clock genes like Period and Cryptochrome. NPAS2 is ...
The DNA-binding basic helix-loop-helix (bHLH; purple) domain, the Per-Arnt-Sim (PAS; blue) domain for transcription factor ... NPAS4 forms a heterodimeric transcription factor with Class II bHLH-PAS proteins ARNT, ARNT2, or ARNTL to bind DNA [539; 571]. ... The bHLH (basic helix-loop-helix) superfamily of transcription factors have important functions in both organismal development ... triphosphate AUC area under the curve BCA bicinchoninic acid BDNF brain-derived neurotrophic factor bHLH basic helix-loop-helix ...
The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and a DNA binding histone ... PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL ... The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone ... RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription ...
... basic helix-loop-helix) transcription factor and, interestingly, a functional analog of the core circadian gene Clock. The ... Clock and Arntl (Bmal1)) and negative (Per1 and Per2 and Cry1 and Cry2) components of these loops in turn drive the circadian ... Gachon F, Olela FF, Schaad O, Descombes P, Schibler U: The circadian PAR-domain basic leucine zipper transcription factors DBP ... Prediction of clock transcription factor binding sites associated with (ar)rhythmic splicing factors. A selection of arrhythmic ...
1.2) Basic helix-loop-helix (bHLH). *ATOH1. *AhR. *AHRR. *ARNT. *ASCL1. *BHLH *2 ... the domain in winged-helix transcription factors (see Regulation of gene expression) has four helices and a two-strand beta- ... Winged-Helix+Transcription+Factors at the US National Library of Medicine Medical Subject Headings (MeSH) ... Retrieved from "https://en.wikipedia.org/w/index.php?title=Winged-helix_transcription_factors&oldid=730546101" ...
... which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their ... Restricts the CLOCK and ARNTL/BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the ... negative regulation of sequence-specific DNA binding transcription factor activity GO:0045087 innate immune response (InnateDB ... Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. ...
  • CLOCK and BMAL1 are bHLH-PAS-containing transcription factors that bind to E-box elements and are indispensable for expression of core circadian clock components such as the Per and Cry genes. (nih.gov)
  • Transient-transfection experiments revealed that heterodimerization of CLOCK and BMAL1 accelerates their turnover, as well as E-box-dependent clock gene transcription. (nih.gov)
  • Moreover, in embryonic mouse fibroblasts, robust transcription of Per2 is tightly associated with massive degradation of the CLOCK/BMAL1 heterodimer. (nih.gov)
  • CRY proteins suppressed this process during the transcription-negative phase and led to nuclear accumulation of the CLOCK/BMAL1 heterodimer. (nih.gov)
  • BMAL1 encodes a transcription factor with a basic helix-loop-helix (bHLH) and two PAS domains. (wikipedia.org)
  • The BMAL1 protein is 626 amino acids long and plays a key role as one of the positive elements in the mammalian auto-regulatory transcription-translation negative feedback loop (TTFL), which is responsible for generating molecular circadian rhythms. (wikipedia.org)
  • The names BMAL1 and ARNTL were adopted in later papers. (wikipedia.org)
  • One of ARNTL protein's earliest discovered functions in circadian regulation was related to the CLOCK-BMAL1 (CLOCK-ARNTL) heterodimer, which would bind through an E-box enhancer to activate the transcription of the AVP gene which encodes for vasopressin. (wikipedia.org)
  • In addition to the circadian regulatory TTFL loop, Bmal1 transcription is regulated by competitive binding to the retinoic acid-related orphan receptor response element-binding site (RORE) within the promoter of Bmal1. (wikipedia.org)
  • The CLOCK/BMAL1 heterodimer also binds to E-box elements in promoter regions of Rev-Erbα and RORα/ß genes, upregulating transcription and translation of REV-ERB and ROR proteins. (wikipedia.org)
  • REV-ERBα and ROR proteins regulate BMAL1 expression through a secondary feedback loop and compete to bind to Rev-Erb/ROR response elements in the Bmal1 promoter, resulting in BMAL1 expression repressed by REV-ERBα and activated by ROR proteins. (wikipedia.org)
  • Several posttranslational modifications of BMAL1 dictate the timing of the CLOCK/BMAL1 feedback loops. (wikipedia.org)
  • In 2004, Rora was discovered to be an activator of Bmal1 transcription within the suprachiasmatic nucleus (SCN), regulated by its core clock. (wikipedia.org)
  • The CLOCK protein acts as a heterodimeric transcription factor with a partner known as BMAL1 (ARNTL). (hhmi.org)
  • The PER and CRY proteins associate and translocate into the nucleus during the evening and physically interact with the CLOCK:BMAL1 complex to repress their own transcription. (hhmi.org)
  • The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cr. (genecards.org)
  • Rev-erb alpha, through its role as a transcriptional repressor, was thought to be the primary determinant of the feedback loop that regulates Bmal1 transcription. (umassmed.edu)
  • in this issue of Neuron now show that the transactivator Rora acts coordinately with Rev-erb alpha and that their competing activities on the same promoter element drive the rhythm in Bmal1 transcription. (umassmed.edu)
  • Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. (nih.gov)
  • This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. (nih.gov)
  • The preferred binding motif for the CLOCK-ARNTL/BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking Ala residue in addition to the canonical 6-nucleotide E-box sequence (PubMed:23229515). (nih.gov)
  • The CLOCK-ARNTL/BMAL1 heterodimer also recognizes the non-canonical E-box motifs 5'-AACGTGA-3' and 5'-CATGTGA-3' (PubMed:23229515). (nih.gov)
  • CLOCK has an intrinsic acetyltransferase activity, which enables circadian chromatin remodeling by acetylating histones and nonhistone proteins, including its own partner ARNTL/BMAL1. (nih.gov)
  • Human NPAS2 is a basic-helix-loop-helix (BHLH) transcription factor with two N-terminal PAS domains that forms a hetero-dimeric complex with BMAL1/ARNTL to regulate the transcription of key circadian clock genes like Period and Cryptochrome. (bangor.ac.uk)
  • Restricts the CLOCK and ARNTL/BMAL1 localization to the cytoplasm. (innatedb.com)
  • PER, in concert with the product of the mammalian timeless gene (TIM), negatively regulates its own transcription by blocking the activity of the CLOCK-BMAL1 transactivation complex. (thermofisher.com)
  • Interacts with CLOCK and ARNTL /BMAL1. (rcsb.org)
  • Class II members include the aryl hydrocarbon receptor nuclear translocator (ARNT, also called HIF-1β), ARNT2, brain and muscle ARNT-like protein 1 (BMAL1, also called ARNTL), and BMAL2 (ARNTL2). (ox.ac.uk)
  • BMAL1:CLOCK/NPAS2 activates transcription of CRY, PER, and several other genes in the morning. (wikipathways.org)
  • Transcription of the BMAL1 (ARNTL) gene is controlled by ROR-alpha and REV-ERBA (NR1D1), both of which are targets of BMAL1:CLOCK/NPAS2 in mice and both of which compete for the same element (RORE) in the BMAL1 promoter. (wikipathways.org)
  • REV-ERBA represses transcription of BMAL1. (wikipathways.org)
  • Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1. (genecards.org)
  • The molecular clock of transcription involves a translational feedback mechanism of genes, including clock circadian regulator (CLOCK), period circadian clock (PER), aryl hydrocarbon receptor nuclear translocator like (BMAL1) and cryptochrome circadian clock (CRY), able to regulate a number of physiological properties, including body temperature, melatonin secretion, hormone secretion, blood pressure and the sleep-wake cycle ( 3 ). (spandidos-publications.com)
  • KO mouse of ARNTL (BMAL1) shows arrhythmic phenotype ( Bunger2000 ). (go.jp)
  • In the positive loop NPAS2 (MOP4) protein [ 7 ], which plays an overlapping role with the CLOCK protein [ 8 ], pairs up with ARNTL (BMAL1 or MOP3) protein. (biomedcentral.com)
  • ARNTL/BMAL1 increases muscle production and decreases fat cell creation. (selfdecode.com)
  • ARNTL/BMAL1 has also been identified as a candidate gene for susceptibility to hypertension, diabetes, and obesity, and mutations in BMAL1 have been linked to infertility, gluconeogenesis and lipogenesis problems, and altered sleep patterns. (selfdecode.com)
  • Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. (epigentek.com)
  • Circadian gene expression is maintained through the coordinated action of basic helix-loop-helix/Per-Arnt-Simpleminded (bHLH-PAS) domain proteins encoded by Clock (or its paralog Npas2 ), Bmal1 , Period ( Per ), and Cryptochrome ( Cry ) genes ( 1 ). (diabetesjournals.org)
  • After accumulating in the cytoplasm, PER and CRY proteins heterodimerize, translocate to the nucleus, and regulate the activity of CLOCK:BMAL1, completing a transcriptional/translational feedback loop ( 4 , 5 ). (diabetesjournals.org)
  • CLOCK:BMAL1 dimers also drive the expression of circadian effector genes, such as those encoding transcription factors albumin d -element-binding protein (DBP) and REV-ERBα, implicated in a multitude of physiological functions ( 6 , 7 ). (diabetesjournals.org)
  • Negative feedback is achieved by PER:CRY heterodimers that translocate back to the nucleus to repress their own transcription by inhibiting the activity of the CLOCK:BMAL1 complexes. (academic.ru)
  • [ 3 ] Another regulatory loop is induced when CLOCK:BMAL1 heterodimers activate the transcription of Rev-ErbA and Rora, two retinoic acid-related orphan nuclear receptors. (academic.ru)
  • While RORs activate transcription of Bmal1 , REV-ERBs repress the same transcription process. (academic.ru)
  • As found from download, BMAL1: matrix( ARNTL: scaffold) and BMAL1: NPAS2( ARNTL: NPAS2) requirements T to cell pathways( isoform cells) in the complexes of talin enzymes and be DNA( Gekakis et al. (evakoch.com)
  • CLOCK and BMAL1 heterodimerise and bind to E-box elements in PERs and CRYs to drive their rhythmic transcription [ 1 , 2 , 3 ]. (biomedcentral.com)
  • The clock consists of a stimulatory loop, with the CLOCK-BMAL1 heterodimer stimulating the transcription of Per and Cry genes, and an inhibitory feedback loop with the PER-CRY heterodimer translocating to the nucleus and repressing the transcription of the Clock and Bmal1 genes. (biomedcentral.com)
  • We show that cry transcription is under circadian regulation, influenced by the Drosophila clock genes period, timeless, Clock, and cycle. (nih.gov)
  • The biological clock is a self-sustained mechanism able to maintain and synchronize circadian rhythms via transcription-translation feedback loops, constituted by core circadian clock genes. (springer.com)
  • This CYC-CLK protein complex binds to E-box elements in promoter regions of the genes period and timeless, functioning as a transcription factor in the translation of the proteins PER and TIM. (wikipedia.org)
  • In the absence of activated GR, other transcription factors such as NF-κB or AP-1 themselves are able to transactivate target genes. (bionity.com)
  • However activated GR can complex with these other transcription factors and prevent them from binding their target genes and hence repress the expression of genes that are normally upregulated by NF-κB or AP-1. (bionity.com)
  • The encoded protein forms both homodimers and heterodimers that bind to DNA E box sequences and regulate the transcription of genes involved in cranial suture closure during skull development. (nih.gov)
  • In the nucleus the complex acts as transcription factors , augmenting or suppressing transcription of particular genes by its action on DNA. (chemeurope.com)
  • Clock proteins combine with Arntl proteins to form heterodimeric transcription factors that are specific for E-BOX ELEMENTS and stimulate the transcription of several E-box genes that are involved in cyclical regulation. (bvsalud.org)
  • Zinc finger protein transcription factors can be encoded by genes small enough to fit a number of such genes into a single vector , allowing the medical intervention and control of expression of multiple genes and the initiation of an elaborate cascade of events. (wikipedia.org)
  • In this respect, it is also possible to target a sequence that is common to multiple (usually functionally related) genes in order to control the transcription of all these genes with a single transcription factor. (wikipedia.org)
  • Also, it is possible to target a family of related genes by targeting and modulating the expression of the endogenous transcription factor(s) that control(s) them. (wikipedia.org)
  • In mammals, several genes that encode members of the basic helix-loop helix (bHLH) PAS (PER-ARNT-SIM) transcription factor family have been shown to play a significant role in regulating circadian oscillations. (thermofisher.com)
  • upon ligand binding, this protein moves to the nucleus and stimulates transcription of target genes. (genecards.org)
  • Ligand binding causes the co-chaperones to dissociate, allowing AHR to translocate to the nucleus, dimerize and alter transcription of target genes. (genecards.org)
  • Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. (creativebiomart.net)
  • Once the activated transcription factors reaches the nucleus it binds to consensus DNA-recognition motif called gamma activated sites (GAS) in the promoter region of cytokine inducible genes and activates transcription of these genes. (wikidoc.org)
  • Once inside the nucleus the active STAT dimer binds to cytokine inducible promoter regions of genes containing gamma activated site (GAS) motif and activate transcription of these genes. (wikidoc.org)
  • The molecular circadian clock consists of multiple positive and negative feedback loops that generate the 24-hour oscillation of target genes. (biomedcentral.com)
  • Variations of the ARNTL gene, as well as two other genes, CRY2 and PER2 , have been found to be associated with unipolar depression, perhaps due to the disruption of the circadian clock as well as other psychotic disorders [ R1 , R2 ]. (selfdecode.com)
  • ARNTL/CLOCK bind to promoter regions EV-Erb and ROR/ß genes as well to begin production of their proteins, which in turn regulate ANTL by binding to the promoter region [ R ]. (selfdecode.com)
  • The family of basic Helix-Loop-Helix ( bHLH ) transcription factors is encoded in humans between 110 to 125 genes, compared with only 59 in the fly (Drosophila). (edu.au)
  • In Arabidopsis thaliana, rhythmic hypocotyl elongation in short days (SD) is enhanced at dawn by the basic-helix-loop-helix (bHLH) transcription factors PHYTOCHROME-INTERACTING FACTORS (PIFs) directly inducing expression of growth-related genes [1-6]. (readbyqxmd.com)
  • The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. (wikipedia.org)
  • • Functional domains of a positive regulatory protein, PHO4 , for transcriptional control of the phosphatase regulon in Saccharomyces cerevisiae. • The PHO4 gene encodes a positive regulatory factor involved in regulating transcription of various genes in the phosphatase regulon of Saccharomyces cerevisiae. • Besides its own coding region, the 1.8-kilobase PHO4 transcript contains a coding region for a mitochondrial protein which does not appear to be translated. http://mcb.asm.org/cgi/content/abstract/10/5/2224 ">Functional domains of a positive regulatory protein, PHO4, for transcriptional control of the phosphatase regulon in Saccharomyces cerevisiae - Functional domains of a positive regulatory protein, PHO4, for transcriptional control of the phosphatase regulon in Saccharomyces cerevisiae. (thefullwiki.org)
  • [ 6 ] Through the analysis of per circadian mutants and additional mutations on Drosophila clock genes, it was demonstrated that there is an underlying generative molecular mechanism of the circadian clock that consists of a set of core clock genes and their protein products, which together participate in positive and negative autoregulatory feedback loops of transcription and translation . (academic.ru)
  • Thus, CLOCK-CYC dimers activate the transcription of circadian genes. (academic.ru)
  • In flies, CLK-CYC binds to the promoters of circadian-regulated genes only at the time of transcription. (academic.ru)
  • The WNT/beta-catenin pathway induces the transcription of genes involved in cell proliferation, i.e. (springeropen.com)
  • We show that the central clock genes ARNTL (Bmal) , Per2 and Per3 , and the peripheral clock genes Rev-erb-α and ROR-α , oscillate before and after differentiation, as does the expression of the neuronal differentiation markers Hes5 , β-3-tubulin (Tubb3) and Stra13 , but not Neurod1 . (jcircadianrhythms.com)
  • The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex. (omicsgroup.org)
  • Brn3a is a transcription factor which acts in development by regulating downstream "target" genes. (wikidoc.org)
  • There are five bHLH genes known in yeast and they function to facilitate transcription in general and to regulate the cell cycle (Ledent, 2001). (sunyorange.edu)
  • [8] It belongs to the Runt-related transcription factor (RUNX) family of genes which are also called core binding factor-α (CBFα). (hitchhikersgui.de)
  • Tumour suppressive Clock Loss genes were negatively correlated with hypoxia inducible factor-1A targets in glioma patients, providing a novel framework for investigating the hypoxia-clock signalling axis. (biomedcentral.com)
  • The circadian oscillations of muscle genes are controlled either directly by the intrinsic muscle clock or by extrinsic factors, such as feeding, hormonal signals, or neural influences, which are in turn regulated by the central pacemaker, the suprachiasmatic nucleus of the hypothalamus. (biomedcentral.com)
  • Orthologs performing the same function in other species include ARNTL and ARNTL2. (wikipedia.org)
  • The CLOCK-ARNTL2/BMAL2 heterodimer activates the transcription of SERPINE1/PAI1 and BHLHE40/DEC1. (nih.gov)
  • PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. (genecards.org)
  • These four proteins of the feedback loop are later degraded by a casein kinase-mediated phosphorylation cycle, allowing fluctuations in gene expression according to environmental cues. (wikipedia.org)
  • These proteins contain a conserved basic DNA binding domain that binds the E box DNA motif [2] . (bionity.com)
  • This interaction probably involves the basic domains of both proteins. (nih.gov)
  • Activates transcription as a heterodimer with E proteins. (nih.gov)
  • Upon binding by the hormone the receptor undergoes a conformational change, the heat shock proteins come off, and the receptor together the with bound hormone enter the nucleus to act upon transcription. (chemeurope.com)
  • CCAAT-enhancer-binding proteins (or C/EBPs) are a family of transcription factors that are composed of six members C/EBP α to C/EBP ζ. (chemeurope.com)
  • Basic helix-loop-helix (bHLH) domain-containing proteins that contain intrinsic HISTONE ACETYLTRANSFERASE activity and play important roles in CIRCADIAN RHYTHM regulation. (bvsalud.org)
  • This transcriptional activation also sets into motion a time-dependent feedback loop which in turn down-regulates the expression of clock proteins. (bvsalud.org)
  • We have recently reported a series of crystal structures showing the bHLH-PAS proteins comprise a distinct family of ligand-binding transcription factors in mammals. (ox.ac.uk)
  • The aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase. (princeton.edu)
  • It consists of RNA polymerase II , a subset of general transcription factors , and regulatory proteins known as SRB proteins. (gutenberg.org)
  • STAT proteins were originally described as latent cytoplasmic transcription factors that require phosphorylation for nuclear retention. (wikidoc.org)
  • Downstream, PER and CRY proteins pair up and execute the negative loop. (biomedcentral.com)
  • 1994). "The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins" . (wikipedia.org)
  • Early growth response proteins are a family of zinc finger transcription factors . (orange.com)
  • When some proteins form a -helices, polar and charged amino acids occur on one side of the helix (where they can interact with the watery environment inside the cell) while the other side of the helix possesses nonpolar amino acids that can interact with nonpolar organic molecules. (sunyorange.edu)
  • Some proteins which regulate transcription are amphipathic including the leucine zipper proteins (which possess an array of leucine amino acids on the nonpolar side of the helix which interacts with DNA) and helix-loop-helix proteins. (sunyorange.edu)
  • Helix-loop-helix (HLH) proteins are a family of 13-20 kDa proteins which share a domain of 2 amphipathic α helices separated by an intervening sequence (Norton, 1998). (sunyorange.edu)
  • Some basic HLH (bHLH) proteins (Class I ) bind to DNA as either homodimers or heterodimers such as E2A and E47 and are known as E proteins. (sunyorange.edu)
  • The HLH region interacts with other bHLH proteins in dimerization and the basic region interacts with specific DNA sequences. (sunyorange.edu)
  • ARNTL/2-CLOCK heterodimers activate E-box element (3'-CACGTG-5') transcription of a number of proteins of the circadian clock. (abcam.cn)
  • This transcription is inhibited in a feedback loop by PER and CRY proteins. (abcam.cn)
  • The transcription of RUNX1 is regulated by 2 enhancers (regulatory element 1 and regulatory element 2), and these tissue specific enhancers enable the binding of lymphoid or erythroid regulatory proteins, therefore the gene activity of RUNX1 is highly active in the haematopoietic system. (hitchhikersgui.de)
  • Members of the ID family of helix-loop-helix (HLH) proteins lack a basic DNA-binding domain and inhibit transcription through formation of nonfunctional dimers that are incapable of binding to DNA. (bioscience.ws)
  • CLOCK forms heterodimer with ARNTL(BMAL) . (go.jp)
  • The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. (origene.com)
  • The glucocorticoid receptor ( GR ) also known as NR3C1 ( nuclear receptor subfamily 3, group C, member 1) is a ligand-activated transcription factor that binds with high affinity to cortisol and other glucocorticoids . (bionity.com)
  • CLOCK specifically binds to the half-site 5'-CAC-3', while ARNTL binds to the half-site 5'-GTGA-3' (PubMed:23229515). (nih.gov)
  • Zinc finger transcription factors or ZF-TFs , are transcription factors composed of a zinc finger - binding domain and any of a variety of transcription-factor effector-domains that exert their modulatory effect in the vicinity of any sequence to which the protein domain binds. (wikipedia.org)
  • Before the start of transcription , the transcription Factor II D (TFIID) complex binds to the TATA box in the core promoter of the gene. (gutenberg.org)
  • 2004). "Human liver specific transcriptional factor TCP10L binds to MAD4. (omicsgroup.org)
  • It is involved in controlling both the sleep-wake cycle and circadian regulation of gene expression by promoting transcription in a negative feedback mechanism. (wikipedia.org)
  • Regulation thus occurs primarily through the negative feedback by the PER-TIM protein complex in the transcription-translation feedback loop described above. (wikipedia.org)
  • Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. (uniprot.org)
  • The regulation of C/EBPβ is exerted in many manners, phosphorylation , acetylation , activation and repression via others transcription factors, oncogenic elements or chemokines , autoregulation, etc. (chemeurope.com)
  • Consisting of about 110 amino acids , the domain in winged-helix transcription factors (see Regulation of gene expression ) has four helices and a two-strand beta-sheet . (wikipedia.org)
  • Regulation of endogenous biological clocks is regulated at the genetic level by a protein-mediated, autoregulatory feed-back loop. (thermofisher.com)
  • The protein encoded by this gene is a ligand-activated helix-loop-helix transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. (genecards.org)
  • This includes the sleep and wake cycle, along with other factors such as hormonal levels, eating, drinking, energy metabolism, cell division, post-transcriptional regulation and regulation of the endocrine system. (jcircadianrhythms.com)
  • At the molecular level, circadian rhythms in gene expression are generated by interconnected transcriptional and translational feedback loops (TTFLs), in which multiple layers of control, including temporal transcriptional, posttranscriptional, and posttranslational regulation, play important roles ( 2 , 3 ). (frontiersin.org)
  • ARNTL(BMAL) is one of the "core loop" gene. (go.jp)
  • The circadian clock in mammals is composed of an autoregulatory transcriptional network with interlocked feedback loops (Figure 1). (hhmi.org)
  • The circadian clock mechanism in mammals involves two interlocking transcriptional feedback loops. (umassmed.edu)
  • The majority of identified clock components are transcriptional activators or repressors that modulate protein stability and nuclear translocation, and create two interlocking feedback loops. (academic.ru)
  • The autoregulatory feedback loops in clocks take about 24 hour to complete a cycle and constitute a circadian molecular clock . (academic.ru)
  • Co-immunoprecipitation studies in MIN6 cells then uncovered competition between NPAS4 and a related transcription factor, HIF1α, for the shared heterodimerization partner, ARNT. (ubc.ca)
  • This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. (creativebiomart.net)
  • The activated receptor interacts with the hormone response element, and the transcription process is initiated as with type I receptors. (chemeurope.com)
  • Mlx, a novel Max-like BHLHZip protein that interacts with the Max network of transcription factors. (omicsgroup.org)
  • Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. (innatedb.com)
  • ARNTL increases vasopressin, an important hormone that regulates water retention the kidney [ R1 , R2 ]. (selfdecode.com)
  • RUNX1 is a transcription factor that regulates the differentiation of hematopoietic stem cells into mature blood cells. (hitchhikersgui.de)
  • Using a combined approach of positional cloning and transgenic (functional) rescue of the Clock mutation in mice, we found that the Clock gene encodes a novel member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. (hhmi.org)
  • The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. (genecards.org)
  • This gene encodes a basic helix-loop-helix (bHLH) transcription factor that plays an important role in embryonic development. (nih.gov)
  • This gene encodes a basic helix-loop-helix protein expressed in various tissues. (senescence.info)
  • This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. (ipfs.io)
  • Antigen standard for aryl hydrocarbon receptor nuclear translocator-like (ARNTL), transcript variant 1 is a lysate prepared from HEK293T cells transiently transfected with a TrueORF gene-carrying pCMV plasmid and then lysed in RIPA Buffer. (creativebiomart.net)
  • BHLHE40, 41 and CWO bind to E-Box and suppress transcription by CLOCK/ARNTL. (go.jp)
  • They are characterized by a highly conserved basic-leucine zipper (bZIP) domain at the C-terminus. (chemeurope.com)
  • This domain is involved in dimerization and DNA binding like other transcription factors of the leucine zipper family like c-Fos and Jun. (chemeurope.com)
  • The different members of C/EBP family can form homodimers, heterodimers with another form of the C/EBPs and with other transcription factors that may or may not contain the leucine zipper domain. (chemeurope.com)
  • Basic Helix-Loop-Helix Leucine Zipper Transcription Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ucdenver.edu)
  • A family of transcription factors that contain regions rich in basic residues, LEUCINE ZIPPER domains, and HELIX-LOOP-HELIX MOTIFS. (ucdenver.edu)
  • This graph shows the total number of publications written about "Basic Helix-Loop-Helix Leucine Zipper Transcription Factors" by people in this website by year, and whether "Basic Helix-Loop-Helix Leucine Zipper Transcription Factors" was a major or minor topic of these publications. (ucdenver.edu)
  • Below are the most recent publications written about "Basic Helix-Loop-Helix Leucine Zipper Transcription Factors" by people in Profiles. (ucdenver.edu)
  • in March under the name Mop3 and Ikeda and Nomura in April as part of a superfamily of PAS domain transcription factors. (wikipedia.org)
  • In 1998, Hogenesch's additional characterization of MOP3 revealed that its role as the partner of bHLH-PAS transcription factor CLOCK was essential to mammalian circadian clock function. (wikipedia.org)
  • The MOP3 protein, as it was originally known by the Hogenesch group, was found to dimerize with MOP4, CLOCK, and hypoxia-inducible factors. (wikipedia.org)
  • Significant heritability of sleepiness, usual bedtime, and usual sleep duration has been discovered [ 9 ], which suggests that genetic factors may make some individuals more susceptible to sleep disturbance. (jcircadianrhythms.com)
  • Cycle is primarily known for its role in the genetic transcription-translation feedback loop that generates circadian rhythms in Drosophila. (wikipedia.org)
  • The Signaling Pathways Project is a multi-omics knowledgebase based upon public, manually curated transcriptomic and cistromic (ChIP-Seq) datasets involving genetic and small molecule manipulations of cellular receptors, enzymes, transcription factors and co-nodes, as well as model and clinical datasets. (plos.org)
  • We study ligand-dependent transcription factors, with a current focus on the human basic Helix Loop Helix-PAS (bHLH-PAS) protein family. (ox.ac.uk)
  • The encoded protein can interact with ARNTL or compete for E-box binding sites in the promoter of PER1 and repress CLOCK/ARNTL's transactivation of PER1. (senescence.info)
  • Rhythmic expression of ARNTL was mediated by RORE sequences in the promoter (Preitner2002) . (go.jp)
  • Our findings link circadian gene variants to the risk factors of the metabolic syndrome, since Npas2 was associated with hypertension (P-value corrected for multiple testing = 0.0024) and Per2 was associated with high fasting blood glucose (P-value corrected for multiple testing = 0.049). (biomedcentral.com)
  • Activates transcription of PER1 and PER2. (abcam.cn)
  • C/EBPs bZIP domain structure is composed of an α-helix that forms a coiled coil structure when it dimerizes. (chemeurope.com)
  • Crystal structure of C/EBPbeta bZip domain (pink helices) bound to DNA(spheres. (worldheritage.org)
  • GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein heterodimerization activity . (genecards.org)
  • It uses material from the Wikipedia article "Myogenic_regulatory_factors" . (bionity.com)
  • CLOCK-ARNT3 heterodimers bind to E box regulatory elements and stimulate gene transcription. (thermofisher.com)
  • The protein encoded by this intronless gene is a bZIP transcription factor that can bind as a homodimer to certain DNA regulatory regions. (worldheritage.org)
  • The circadian clock is cell-autonomous and some, but not all cells of the body exhibit circadian rhythms in metabolism, cell division, and gene transcription. (wikipathways.org)
  • Several mechanisms have been proposed as contributory factors in the pathogenesis of motor neuron damage in sALS including excitoxicity, mitochondrial and energy metabolism failure, oxidative stress damage, altered glial cells, inflammation, cytoskeletal ab-normalities, alterations in RNA metabolism, and altered TDP-43 metabolism, among others [ 3 - 16 ]. (aging-us.com)
  • The TIM protein in these complexes mediate the accumulation of the dimeric PER-TIM protein complex and their subsequent importation into the nucleus, where the PER protein in these complexes then mediates the release of CYC-CLK from the chromatin, repressing CYC-CLK dependent transcription. (wikipedia.org)
  • A direct mechanism of action involves homodimerization of the receptor, translocation via active transport into the nucleus , and binding to specific DNA responsive elements activating gene transcription . (bionity.com)
  • The STAT protein can be dephosphorylated by nuclear phosphatases which leads to inactivation of STAT and the transcription factor becomes transported out of the nucleus by exportin crm1/RanGTP. (wikidoc.org)
  • They are a hTERT-BJ1 trisphosphate nucleus in the other set response of the stimulating conjunction in sustainable, and receptors with the logical bacteria, termed nuclear web aspects, can activate known in factor from formed transcription peptides by protein of a molecule of disorder transmembrane devices( Takahashi and Yamanaka 2006, Takahashi et al. (evakoch.com)
  • 2004). "Attenuation of HIV-1 replication in primary human cells with a designed zinc finger transcription factor" . (wikipedia.org)
  • They also have the advantage that the targeted sequence need not be symmetrical unlike with most other DNA-binding motifs based on natural transcription factors that bind as dimers. (wikipedia.org)
  • All the members of the C/EBP family, except C/EBPγ, can induce transcription, through their activation domains, by interacting with components of the basal transcription apparatus. (chemeurope.com)
  • Within this family, class I and class II members heterodimerize to generate functional transcription factors. (ox.ac.uk)
  • PIT1 is a pituitary-specific transcription factor responsible for pituitary development and hormone expression in mammals and is a member of the POU family of transcription factors that regulate mammalian development. (wikidoc.org)
  • A tale of three fingers: the family of mammalian Sp/XKLF transcription factors. (ipfs.io)
  • The transcription factors of this family are activated by the Janus Kinase JAK and dysregulation of this pathway is frequently observed in primary tumors and leads to increased angiogenesis , enhanced survival of tumors and immunosuppression . (wikidoc.org)
  • [1] The structural motif describing this transcription factor family refers to the two α-helices connected by a loop. (edu.au)
  • 1995). "The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons. (thefullwiki.org)
  • Levrero M, De Laurenzi V, Costanzo A, Gong J, Wang JY, Melino G. The p53/p63/p73 family of transcription factors: overlapping and distinct functions . (wikiwand.com)
  • Iroquois homeobox factors are a family of homeodomain transcription factors that play a role in many developmental processes. (rug.nl)
  • This gene is a member of the paired box ( PAX ) family of transcription factors which are essential during fetal development. (omicsgroup.org)
  • General transcription factor IIH subunit 4 is a protein that in humans is encoded by the GTF2H4 gene . (hawaiilibrary.net)
  • Runt-related transcription factor 1 ( RUNX1 ) also known as acute myeloid leukemia 1 protein (AML1) or core-binding factor subunit alpha-2 (CBFA2) is a protein that in humans is encoded by the RUNX1 gene . (hitchhikersgui.de)
  • The Signal Transducers and Activator of Transcription (STAT) protein s regulate many aspects of cell growth , survival and differentiation . (wikidoc.org)
  • The differentiation of neuroepithelial cells (neurogenesis) involves a number of basic helix-loop-helix (bHLH) transcription factors Mash 1 (Homolog of achaete-scute in Drosophila), neurogenin, and NeuroD. (sunyorange.edu)
  • Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2. (uniprot.org)
  • [ 1 ] The basic molecular mechanisms of the biological clock have been defined in vertebrate species, Drosophila melanogaster , plants, fungi, and bacteria. (academic.ru)
  • Twist was first identified in Drosophila as a transcription factor which functioned at gastrulation (Massari, 2000). (sunyorange.edu)
  • In mammals, circadian rhythmicity is sustained via a transcriptional/translational feedback loop referred to as the canonical molecular circadian clock. (jcircadianrhythms.com)
  • The core oscillator is coordinated by a set of interlocking transcriptional-translational feedback loop. (biomedcentral.com)
  • T-box refers to a group of transcription factors involved in embryonic limb and heart development. (rug.nl)
  • The mouse T gene was cloned, [6] and proved that brachyury was a 436 amino acid embryonic nuclear transcription factor . (rug.nl)
  • Associations between these SNPs and seasonality, metabolic syndrome and its risk factors were analyzed using regression analysis. (biomedcentral.com)
  • In molecular biology , Activating Transcription Factor , ATF , is a class of AP-1 transcription factor dimers. (wikidoc.org)