Base Pairing
Base Sequence
Skull Base
Schiff Bases
Skull Base Neoplasms
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Base Pair Mismatch
The presence of an uncomplimentary base in double-stranded DNA caused by spontaneous deamination of cytosine or adenine, mismatching during homologous recombination, or errors in DNA replication. Multiple, sequential base pair mismatches lead to formation of heteroduplex DNA; (NUCLEIC ACID HETERODUPLEXES).
Nucleic Acid Conformation
DNA
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Denture Bases
Amino Acid Sequence
Knowledge Bases
Escherichia coli
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Mannich Bases
Oligodeoxyribonucleotides
Mutation
Cloning, Molecular
Models, Molecular
DNA Glycosylases
A family of DNA repair enzymes that recognize damaged nucleotide bases and remove them by hydrolyzing the N-glycosidic bond that attaches them to the sugar backbone of the DNA molecule. The process called BASE EXCISION REPAIR can be completed by a DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE which excises the remaining RIBOSE sugar from the DNA.
Oligonucleotides
DNA Repair
The reconstruction of a continuous two-stranded DNA molecule without mismatch from a molecule which contained damaged regions. The major repair mechanisms are excision repair, in which defective regions in one strand are excised and resynthesized using the complementary base pairing information in the intact strand; photoreactivation repair, in which the lethal and mutagenic effects of ultraviolet light are eliminated; and post-replication repair, in which the primary lesions are not repaired, but the gaps in one daughter duplex are filled in by incorporation of portions of the other (undamaged) daughter duplex. Excision repair and post-replication repair are sometimes referred to as "dark repair" because they do not require light.
Hydrogen Bonding
Binding Sites
Transcription, Genetic
Plasmids
RNA
A polynucleotide consisting essentially of chains with a repeating backbone of phosphate and ribose units to which nitrogenous bases are attached. RNA is unique among biological macromolecules in that it can encode genetic information, serve as an abundant structural component of cells, and also possesses catalytic activity. (Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
Lewis Bases
Genes
Sequence Homology, Nucleic Acid
Nucleic Acid Hybridization
Widely used technique which exploits the ability of complementary sequences in single-stranded DNAs or RNAs to pair with each other to form a double helix. Hybridization can take place between two complimentary DNA sequences, between a single-stranded DNA and a complementary RNA, or between two RNA sequences. The technique is used to detect and isolate specific sequences, measure homology, or define other characteristics of one or both strands. (Kendrew, Encyclopedia of Molecular Biology, 1994, p503)
Substrate Specificity
Promoter Regions, Genetic
Restriction Mapping
DNA-(Apurinic or Apyrimidinic Site) Lyase
A DNA repair enzyme that catalyses the excision of ribose residues at apurinic and apyrimidinic DNA sites that can result from the action of DNA GLYCOSYLASES. The enzyme catalyzes a beta-elimination reaction in which the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. This enzyme was previously listed under EC 3.1.25.2.
N-Glycosyl Hydrolases
Nucleic Acid Heteroduplexes
Double-stranded nucleic acid molecules (DNA-DNA or DNA-RNA) which contain regions of nucleotide mismatches (non-complementary). In vivo, these heteroduplexes can result from mutation or genetic recombination; in vitro, they are formed by nucleic acid hybridization. Electron microscopic analysis of the resulting heteroduplexes facilitates the mapping of regions of base sequence homology of nucleic acids.
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Sequence Analysis, DNA
Nucleotides
DNA Polymerase beta
Purines
Thermodynamics
A rigorously mathematical analysis of energy relationships (heat, work, temperature, and equilibrium). It describes systems whose states are determined by thermal parameters, such as temperature, in addition to mechanical and electromagnetic parameters. (From Hawley's Condensed Chemical Dictionary, 12th ed)
Molecular Structure
Codon
A set of three nucleotides in a protein coding sequence that specifies individual amino acids or a termination signal (CODON, TERMINATOR). Most codons are universal, but some organisms do not produce the transfer RNAs (RNA, TRANSFER) complementary to all codons. These codons are referred to as unassigned codons (CODONS, NONSENSE).
Hydrogen-Ion Concentration
Anticodon
Magnetic Resonance Spectroscopy
Guanosine
Polymerase Chain Reaction
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Repetitive Sequences, Nucleic Acid
Sequences of DNA or RNA that occur in multiple copies. There are several types: INTERSPERSED REPETITIVE SEQUENCES are copies of transposable elements (DNA TRANSPOSABLE ELEMENTS or RETROELEMENTS) dispersed throughout the genome. TERMINAL REPEAT SEQUENCES flank both ends of another sequence, for example, the long terminal repeats (LTRs) on RETROVIRUSES. Variations may be direct repeats, those occurring in the same direction, or inverted repeats, those opposite to each other in direction. TANDEM REPEAT SEQUENCES are copies which lie adjacent to each other, direct or inverted (INVERTED REPEAT SEQUENCES).
DNA-Binding Proteins
DNA-Directed DNA Polymerase
DNA-dependent DNA polymerases found in bacteria, animal and plant cells. During the replication process, these enzymes catalyze the addition of deoxyribonucleotide residues to the end of a DNA strand in the presence of DNA as template-primer. They also possess exonuclease activity and therefore function in DNA repair.
DNA Primers
RNA, Transfer
The small RNA molecules, 73-80 nucleotides long, that function during translation (TRANSLATION, GENETIC) to align AMINO ACIDS at the RIBOSOMES in a sequence determined by the mRNA (RNA, MESSENGER). There are about 30 different transfer RNAs. Each recognizes a specific CODON set on the mRNA through its own ANTICODON and as aminoacyl tRNAs (RNA, TRANSFER, AMINO ACYL), each carries a specific amino acid to the ribosome to add to the elongating peptide chains.
Structure-Activity Relationship
Temperature
DNA-Formamidopyrimidine Glycosylase
Sequence Alignment
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
Mutagenesis
Protein Binding
RNA, Bacterial
Crystallography, X-Ray
Introns
Deoxyribonuclease (Pyrimidine Dimer)
Templates, Genetic
Uracil-DNA Glycosidase
Catalysis
Mutagenesis, Site-Directed
Sequence Homology, Amino Acid
DNA Adducts
Oligonucleotide Probes
Synthetic or natural oligonucleotides used in hybridization studies in order to identify and study specific nucleic acid fragments, e.g., DNA segments near or within a specific gene locus or gene. The probe hybridizes with a specific mRNA, if present. Conventional techniques used for testing for the hybridization product include dot blot assays, Southern blot assays, and DNA:RNA hybrid-specific antibody tests. Conventional labels for the probe include the radioisotope labels 32P and 125I and the chemical label biotin.
DNA, Single-Stranded
RNA, Ribosomal
The most abundant form of RNA. Together with proteins, it forms the ribosomes, playing a structural role and also a role in ribosomal binding of mRNA and tRNAs. Individual chains are conventionally designated by their sedimentation coefficients. In eukaryotes, four large chains exist, synthesized in the nucleolus and constituting about 50% of the ribosome. (Dorland, 28th ed)
Saccharomyces cerevisiae
Intercalating Agents
Protons
Point Mutation
Species Specificity
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
Endodeoxyribonucleases
Protein Conformation
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
Single-Strand Specific DNA and RNA Endonucleases
Enzymes that catalyze the endonucleolytic cleavage of single-stranded regions of DNA or RNA molecules while leaving the double-stranded regions intact. They are particularly useful in the laboratory for producing "blunt-ended" DNA molecules from DNA with single-stranded ends and for sensitive GENETIC TECHNIQUES such as NUCLEASE PROTECTION ASSAYS that involve the detection of single-stranded DNA and RNA.
Models, Chemical
RNA, Catalytic
RNA that has catalytic activity. The catalytic RNA sequence folds to form a complex surface that can function as an enzyme in reactions with itself and other molecules. It may function even in the absence of protein. There are numerous examples of RNA species that are acted upon by catalytic RNA, however the scope of this enzyme class is not limited to a particular type of substrate.
Acid-Base Equilibrium
Frameshift Mutation
A type of mutation in which a number of NUCLEOTIDES deleted from or inserted into a protein coding sequence is not divisible by three, thereby causing an alteration in the READING FRAMES of the entire coding sequence downstream of the mutation. These mutations may be induced by certain types of MUTAGENS or may occur spontaneously.
DNA, Recombinant
Protein Biosynthesis
Regulatory Sequences, Nucleic Acid
Models, Genetic
Bacteriorhodopsins
Operon
DNA, Complementary
Gene Expression Regulation
Nucleosides
Sphingolipids
A class of membrane lipids that have a polar head and two nonpolar tails. They are composed of one molecule of the long-chain amino alcohol sphingosine (4-sphingenine) or one of its derivatives, one molecule of a long-chain acid, a polar head alcohol and sometimes phosphoric acid in diester linkage at the polar head group. (Lehninger et al, Principles of Biochemistry, 2nd ed)
Chromosome Mapping
Ointment Bases
Transcription Factors
Spectrophotometry, Ultraviolet
Catalytic Domain
Nuclear Magnetic Resonance, Biomolecular
Cattle
Poly dA-dT
Alkylation
Deoxyribonucleotides
RNA Splicing
Water
Carbon-Oxygen Lyases
Deoxyribonuclease I
An enzyme capable of hydrolyzing highly polymerized DNA by splitting phosphodiester linkages, preferentially adjacent to a pyrimidine nucleotide. This catalyzes endonucleolytic cleavage of DNA yielding 5'-phosphodi- and oligonucleotide end-products. The enzyme has a preference for double-stranded DNA.
Genetic Code
Osmium Tetroxide
Methylation
Nucleic Acids
Electrophoresis, Polyacrylamide Gel
Transfection
Hypoxanthine
Pentoxyl
Chemistry
Consensus Sequence
A theoretical representative nucleotide or amino acid sequence in which each nucleotide or amino acid is the one which occurs most frequently at that site in the different sequences which occur in nature. The phrase also refers to an actual sequence which approximates the theoretical consensus. A known CONSERVED SEQUENCE set is represented by a consensus sequence. Commonly observed supersecondary protein structures (AMINO ACID MOTIFS) are often formed by conserved sequences.
Cytidine
RNA, Transfer, Ala
HeLa Cells
DNA Polymerase I
A DNA-dependent DNA polymerase characterized in prokaryotes and may be present in higher organisms. It has both 3'-5' and 5'-3' exonuclease activity, but cannot use native double-stranded DNA as template-primer. It is not inhibited by sulfhydryl reagents and is active in both DNA synthesis and repair. EC 2.7.7.7.
Conserved Sequence
Chemical Phenomena
Deoxyribonucleases, Type II Site-Specific
Enzyme systems containing a single subunit and requiring only magnesium for endonucleolytic activity. The corresponding modification methylases are separate enzymes. The systems recognize specific short DNA sequences and cleave either within, or at a short specific distance from, the recognition sequence to give specific double-stranded fragments with terminal 5'-phosphates. Enzymes from different microorganisms with the same specificity are called isoschizomers. EC 3.1.21.4.
Deoxyadenosines
Sphingosine
Recombination, Genetic
DNA Probes
Species- or subspecies-specific DNA (including COMPLEMENTARY DNA; conserved genes, whole chromosomes, or whole genomes) used in hybridization studies in order to identify microorganisms, to measure DNA-DNA homologies, to group subspecies, etc. The DNA probe hybridizes with a specific mRNA, if present. Conventional techniques used for testing for the hybridization product include dot blot assays, Southern blot assays, and DNA:RNA hybrid-specific antibody tests. Conventional labels for the DNA probe include the radioisotope labels 32P and 125I and the chemical label biotin. The use of DNA probes provides a specific, sensitive, rapid, and inexpensive replacement for cell culture techniques for diagnosing infections.
Ultraviolet Rays
That portion of the electromagnetic spectrum immediately below the visible range and extending into the x-ray frequencies. The longer wavelengths (near-UV or biotic or vital rays) are necessary for the endogenous synthesis of vitamin D and are also called antirachitic rays; the shorter, ionizing wavelengths (far-UV or abiotic or extravital rays) are viricidal, bactericidal, mutagenic, and carcinogenic and are used as disinfectants.
Software
Blotting, Southern
5-Methylcytosine
DNA Ligases
Circular Dichroism
Chromatography, High Pressure Liquid
Phenotype
Models, Biological
Gene Library
Genes, Regulator
Evolution, Molecular
DNA-Directed RNA Polymerases
Enzymes that catalyze DNA template-directed extension of the 3'-end of an RNA strand one nucleotide at a time. They can initiate a chain de novo. In eukaryotes, three forms of the enzyme have been distinguished on the basis of sensitivity to alpha-amanitin, and the type of RNA synthesized. (From Enzyme Nomenclature, 1992).
Computer Simulation
Chordoma
Bacteriophage lambda
Echinomycin
Blotting, Northern
Biological Evolution
Pyrimidines
Algorithms
Cross-Linking Reagents
Reagents with two reactive groups, usually at opposite ends of the molecule, that are capable of reacting with and thereby forming bridges between side chains of amino acids in proteins; the locations of naturally reactive areas within proteins can thereby be identified; may also be used for other macromolecules, like glycoproteins, nucleic acids, or other.
DNA Breaks, Single-Stranded
Retinaldehyde
A carotenoid constituent of visual pigments. It is the oxidized form of retinol which functions as the active component of the visual cycle. It is bound to the protein opsin forming the complex rhodopsin. When stimulated by visible light, the retinal component of the rhodopsin complex undergoes isomerization at the 11-position of the double bond to the cis-form; this is reversed in "dark" reactions to return to the native trans-configuration.
Deoxyribonuclease IV (Phage T4-Induced)
DNA, Mitochondrial
Poly A
DNA Transposable Elements
Discrete segments of DNA which can excise and reintegrate to another site in the genome. Most are inactive, i.e., have not been found to exist outside the integrated state. DNA transposable elements include bacterial IS (insertion sequence) elements, Tn elements, the maize controlling elements Ac and Ds, Drosophila P, gypsy, and pogo elements, the human Tigger elements and the Tc and mariner elements which are found throughout the animal kingdom.
Stereoisomerism
Open Reading Frames
Alkylating Agents
Highly reactive chemicals that introduce alkyl radicals into biologically active molecules and thereby prevent their proper functioning. Many are used as antineoplastic agents, but most are very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. They have also been used as components in poison gases.
DNA Repair Enzymes
Chloramphenicol O-Acetyltransferase
An enzyme that catalyzes the acetylation of chloramphenicol to yield chloramphenicol 3-acetate. Since chloramphenicol 3-acetate does not bind to bacterial ribosomes and is not an inhibitor of peptidyltransferase, the enzyme is responsible for the naturally occurring chloramphenicol resistance in bacteria. The enzyme, for which variants are known, is found in both gram-negative and gram-positive bacteria. EC 2.3.1.28.
Pyrimidine Nucleotides
Operator Regions, Genetic
A computational screen for methylation guide snoRNAs in yeast. (1/2613)
Small nucleolar RNAs (snoRNAs) are required for ribose 2'-O-methylation of eukaryotic ribosomal RNA. Many of the genes for this snoRNA family have remained unidentified in Saccharomyces cerevisiae, despite the availability of a complete genome sequence. Probabilistic modeling methods akin to those used in speech recognition and computational linguistics were used to computationally screen the yeast genome and identify 22 methylation guide snoRNAs, snR50 to snR71. Gene disruptions and other experimental characterization confirmed their methylation guide function. In total, 51 of the 55 ribose methylated sites in yeast ribosomal RNA were assigned to 41 different guide snoRNAs. (+info)Base pairing of anhydrohexitol nucleosides with 2,6-diaminopurine, 5-methylcytosine and uracil asbase moiety. (2/2613)
Hexitol nucleic acids (HNAs) with modified bases (5-methylcytosine, 2,6-diaminopurine or uracil) were synthesized. The introduction of the 5-methylcytosine base demonstrates that N -benzoylated 5-methylcytosyl-hexitol occurs as the imino tautomer. The base pairing systems (G:CMe, U:D, T:D and U:A) obey Watson-Crick rules. Substituting hT for hU, hCMefor hC and hD for hA generally leads to increased duplex stability. In a single case, replacement of hC by hCMedid not result in duplex stabilization. This sequence-specific effect could be explained by the geometry of the model duplex used for carrying out the thermal stability study. Generally, polypurine HNA sequences give more stable duplexes with their RNA complement than polypyrimidine HNA sequences. This observation supports the hypothesis that, besides changes in stacking pattern, the difference in conformational stress between purine and pyrimidine nucleosides may contribute to duplex stability. Introduction of hCMeand hD in HNA sequences further increases the potential of HNA to function as a steric blocking agent. (+info)Smoothing of the thermal stability of DNA duplexes by using modified nucleosides and chaotropic agents. (3/2613)
The effect of alkyltrimethylammonium ions on the thermostability of natural and modified DNA duplexes has been investigated. We have shown that the use of tetramethylammonium ions TMA+along with the chemical modification of duplexes allow the fine adjustment of T m and the possibility of obtaining several duplex systems with varied isostabilizedtemperatures, some of which show greater stability than those of natural DNA. This approach could be very useful for DNA sequencing by hybridization. (+info)Complete sequence of a 184-kilobase catabolic plasmid from Sphingomonas aromaticivorans F199. (4/2613)
The complete 184,457-bp sequence of the aromatic catabolic plasmid, pNL1, from Sphingomonas aromaticivorans F199 has been determined. A total of 186 open reading frames (ORFs) are predicted to encode proteins, of which 79 are likely directly associated with catabolism or transport of aromatic compounds. Genes that encode enzymes associated with the degradation of biphenyl, naphthalene, m-xylene, and p-cresol are predicted to be distributed among 15 gene clusters. The unusual coclustering of genes associated with different pathways appears to have evolved in response to similarities in biochemical mechanisms required for the degradation of intermediates in different pathways. A putative efflux pump and several hypothetical membrane-associated proteins were identified and predicted to be involved in the transport of aromatic compounds and/or intermediates in catabolism across the cell wall. Several genes associated with integration and recombination, including two group II intron-associated maturases, were identified in the replication region, suggesting that pNL1 is able to undergo integration and excision events with the chromosome and/or other portions of the plasmid. Conjugative transfer of pNL1 to another Sphingomonas sp. was demonstrated, and genes associated with this function were found in two large clusters. Approximately one-third of the ORFs (59 of them) have no obvious homology to known genes. (+info)Mutated epithelial cadherin is associated with increased tumorigenicity and loss of adhesion and of responsiveness to the motogenic trefoil factor 2 in colon carcinoma cells. (5/2613)
Epithelial (E)-cadherin and its associated cytoplasmic proteins (alpha-, beta-, and gamma-catenins) are important mediators of epithelial cell-cell adhesion and intracellular signaling. Much evidence exists suggesting a tumor/invasion suppressor role for E-cadherin, and loss of expression, as well as mutations, has been described in a number of epithelial cancers. To investigate whether E-cadherin gene (CDH1) mutations occur in colorectal cancer, we screened 49 human colon carcinoma cell lines from 43 patients by single-strand conformation polymorphism (SSCP) analysis and direct sequencing. In addition to silent changes, polymorphisms, and intronic variants in a number of the cell lines, we detected frameshift single-base deletions in repeat regions of exon 3 (codons 120 and 126) causing premature truncations at codon 216 in four replication-error-positive (RER+) cell lines (LS174T, HCT116, GP2d, and GP5d) derived from 3 patients. In LS174T such a mutation inevitably contributes to its lack of E-cadherin protein expression and function. Transfection of full-length E-cadherin cDNA into LS174T cells enhanced intercellular adhesion, induced differentiation, retarded proliferation, inhibited tumorigenicity, and restored responsiveness to the migratory effects induced by the motogenic trefoil factor 2 (human spasmolytic polypeptide). These results indicate that, although inactivating E-cadherin mutations occur relatively infrequently in colorectal cancer cell lines overall (3/43 = 7%), they are more common in cells with an RER+ phenotype (3/10 = 30%) and may contribute to the dysfunction of the E-cadherin-catenin-mediated adhesion/signaling system commonly seen in these tumors. These results also indicate that normal E-cadherin-mediated cell adhesion can restore the ability of colonic tumor cells to respond to trefoil factor 2. (+info)High base pair opening rates in tracts of GC base pairs. (6/2613)
Sequence-dependent structural features of the DNA double helix have a strong influence on the base pair opening dynamics. Here we report a detailed study of the kinetics of base pair breathing in tracts of GC base pairs in DNA duplexes derived from 1H NMR measurements of the imino proton exchange rates upon titration with the exchange catalyst ammonia. In the limit of infinite exchange catalyst concentration, the exchange times of the guanine imino protons of the GC tracts extrapolate to much shorter base pair lifetimes than commonly observed for isolated GC base pairs. The base pair lifetimes in the GC tracts are below 5 ms for almost all of the base pairs. The unusually rapid base pair opening dynamics of GC tracts are in striking contrast to the behavior of AT tracts, where very long base pair lifetimes are observed. The implication of these findings for the structural principles governing spontaneous helix opening as well as the DNA-binding specificity of the cytosine-5-methyltransferases, where flipping of the cytosine base has been observed, are discussed. (+info)How translational accuracy influences reading frame maintenance. (7/2613)
Most missense errors have little effect on protein function, since they only exchange one amino acid for another. However, processivity errors, frameshifting or premature termination result in a synthesis of an incomplete peptide. There may be a connection between missense and processivity errors, since processivity errors now appear to result from a second error occurring after recruitment of an errant aminoacyl-tRNA, either spontaneous dissociation causing premature termination or translational frameshifting. This is clearest in programmed translational frameshifting where the mRNA programs errant reading by a near-cognate tRNA; this error promotes a second frameshifting error (a dual-error model of frameshifting). The same mechanism can explain frameshifting by suppressor tRNAs, even those with expanded anticodon loops. The previous model that suppressor tRNAs induce quadruplet translocation now appears incorrect for most, and perhaps for all of them. We suggest that the 'spontaneous' tRNA-induced frameshifting and 'programmed' mRNA-induced frameshifting use the same mechanism, although the frequency of frameshifting is very different. This new model of frameshifting suggests that the tRNA is not acting as the yardstick to measure out the length of the translocation step. Rather, the translocation of 3 nucleotides may be an inherent feature of the ribosome. (+info)Trans-activation of the Tetrahymena group I intron ribozyme via a non-native RNA-RNA interaction. (8/2613)
The peripheral P2.1 domain of the Tetrahymena group I intron ribozyme has been shown to be non-essential for splicing. We found, however, that separately prepared P2.1 RNA efficiently accelerates the 3' splice-site-specific hydrolysis reaction of a mutant ribozyme lacking both P2.1 and its upstream region in trans. We report here the unusual properties of this trans-activation. Compensatory mutational analysis revealed that non-native long-range base-pairings between the loop region of P2.1 RNA and L5c region of the mutant ribozyme are needed for the activation in spite of the fact that P2.1 forms base-pairings with P9.1 in the Tetrahymena ribozyme. The trans -activation depends on the non-native RNA-RNA interaction together with the higher order structure of P2.1 RNA. This activation is unique among the known trans-activations that utilize native tertiary interactions or RNA chaperons. (+info)
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2/4] msvcirt: Add implementation of streambuf buffer getters
Browse All Questions & Answers
Results Base - Tewkesbury Half Marathon and 10k 2014
Quick Base to Receive Majority Investment from Vista Equity Partners
Idéal Soleil Efeito Base FPS50 | Vichy | Skincarisma
2F87: FR3D Base Pair Interactions
KlenTaq polymerase replicates unnatural base pairs by inducing a Watson-Crick geometry | Nature Chemical Biology
Many candidate unnatural DNA base pairs have been developed, but some of the best-replicated pairs adopt intercalated ... A structural study shows that DNA polymerases enhance the efficiency of non-natural base pair replication by enforcing a ... code have relied on synthetic DNA nucleotides designed to have pairing properties orthogonal to those of natural base pairs. ... Here we present crystal structures of KlenTaq DNA polymerase at different stages of replication for one such pair, dNaM-d5SICS ...
British Library EThOS: Pairing-based cryptosystems and key agreement protocols
Identity-based two-party key agreement protocols from pairings are also investigated. The Bellare-Rogaway key agreement model ... Only recently after some pioneering works, particularly the well-known Boneh-Franklin identity-based encryption (IBE), pairings ... Based on the Sakai-Kasahara key construction, an IBE scheme which is secure in the Boneh-Franklin IBE model is constructed, and ... In this thesis, several new cryptographic schemes with pairings are proposed, which are both efficient and secure with respect ...
IMG! Theme (Podcast Websites Exclusive Theme) - Knowledge Base - Pair Networks
Hide "Hosted by Pair". Your footer displays "Hosted by Pair Networks" by default. If you want to remove this text, select Yes ... Hide the "Hosted by Pair Networks" text. Logo. Add a logo to your websites header. Add or manage your logo by going to Layout ... If youre using the Pair Podcast IMG! theme, follow these steps to access the website customizer: *In the left sidebar, hover ...
Bridgedale COOLMAX Base Layer Boot Liner Socks - 2 Pairs - Men's | REI Co-op
... this 2-pack of Bridgedale COOLMAX Base Layer Boot liner socks employs COOLMAX® polyester to help keep your feet dry and ... Bridgedale COOLMAX Base Layer Boot Liner Socks - 2 Pairs - Mens 4.211 ReviewsView the 11 reviews with an average rating of 4.2 ... Delivering comfort, extra warmth and trail-mileage practicality, this 2-pack of Bridgedale COOLMAX Base Layer Boot liner socks ...
Molecular mechanism of base pairing infidelity during DNA duplication upon one-electron oxidation
Figure 5 As the two strands of the double helix unwind, each pairs up with the appropriate bases to form a new double helix. ... Citation: Reynisson J. Molecular mechanism of base pairing infidelity during DNA duplication upon one-electron oxidation. World ... Reynisson J. Molecular mechanism of base pairing infidelity during DNA duplication upon one-electron oxidation. World J Clin ... which is promiscuous with regard to base pairing. ...
RCSB PDB - 1K4S: HUMAN DNA TOPOISOMERASE I IN COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX
HUMAN DNA TOPOISOMERASE I IN COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX ... HUMAN DNA TOPOISOMERASE I IN COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX. *PDB DOI: 10.2210/pdb1K4S/pdb ... Topotecan mimics a DNA base pair and binds at the site of DNA cleavage by intercalating between the upstream (-1) and ... Topotecan mimics a DNA base pair and binds at the site of DNA cleavage by intercalating between the upstream (-1) and ...
New ID-Based Threshold Signature Scheme from Bilinear Pairings | Sciweavers
ID-based public key systems allow the user to use his/her identity as the public key, which can simplify key management ... procedure compared with CA-based public key systems. However, there is an inherent disadvantage in such systems: the problem of ... New ID-Based Threshold Signature Scheme from Bilinear Pairings - ... New ID-Based Threshold Signature Scheme from Bilinear Pairings ... first proposed a novel ID-based signature scheme without trusted PKG from bilinear pairings [10], i.e., there is only one PKG ...
Privacy Enhancing Protocols using Pairing Based Cryptography - DORAS
Sheedy, Caroline (2010) Privacy Enhancing Protocols using Pairing Based Cryptography. PhD thesis, Dublin City University. ... We present existing cryptographic constructions which use bilinear pairings, namely Identity-Based Encryption (IBE). We define ... Our constructions are based on a special type of algebraic group called bilinear groups. ...
Hidden Base Plate Pair - Brushed Nickel Finish | BeverageFactory.com
Hidden Base Plate Pair replaces one standard mounting plate on FCF ... VintageView Hidden Base Plate Pair - Brushed Nickel Finish Model: FCF-HIDDEN-P. * ... The Floor-to-Ceiling Hidden Base Plate is a minimalist version of the standard base plate, removing the connecting steel ... This Brushed Nickel Hidden Base Plate replaces standard Base Plate Mounts on any Floor-to-Ceiling Frame installation ...
A PAIR OF CHINESE GREEN SOAPSTONE FIGURES of kylins seated on their haunches on waisted rectangular bases carved with drapery ...
A pair of anodised metal beakers with bacchanalian scenes, on marble bases, 7' high
A pair of anodised metal beakers with bacchanalian scenes, on marble bases, 7 high. In Fine Art, Antiques and Collectors Items ... A pair of Georgian bell metal candle sticks on stepped square bases, 22cm high together with a ... A pair of Japanese base metal vases cast in high relief with fierce three-clawed dragons, ... A pair of silver candle sticks of plain tapered form to weighted circular bases, Birmingham 1964, ...
Pair find enough backers of crackers to fund a business based on tree seeds
... Sarah Scully ... The pair were recently looking at commercial cooking spaces in Houston.. "Weve boot-strapped it ourselves to start," Copp said ... Acorns may have made up half of their diet in what is now California, Copp and Brown estimate, based on their research. ... Crackers were a good choice, Copp and Brown said, because theyre shelf products that dont go bad quickly and pair with cheese ...
Calix[4]arene-based ion or ion-pair receptors
... arene-based ion and ion-pair receptors. Chapter 1 describes an overview of sensitive ion selective chromogenic and fluoregenic ... This work serves to extend the fundamental chemistry of calix[4]arene-based cesium ion recognition to new research areas. ... In Chapter 4, graphene field-effect transistors (GFETs) are introduced for cesium ion sensing based on electrostatic ... pyrrole system gives rise to a colorimetric response when only exposed to simple ion pairs containing the cesium cation. ...
Beyond Base Pairs to Bedside: A Community Consultation on Closing the Gap between Genomic Discoveries and the Public's Health |...
Beyond Base Pairs to Bedside: A Community Consultation on Closing the Gap between Genomic Discoveries and the Publics Health ... Beyond Base Pairs to Bedside: A Community Consultation on Closing the Gap between Genomic Discoveries and the Publics Health. ... "beyond base pairs to bedside".. As the field of genomics and related technologies continues to mature in the next decade, we ... Implement evidence-based genomic applications and discourage use of unvalidated applications through policy, educational and ...
HybridBlock Partners with TrustToken to Bring TrueUSD Stablecoin to Exchange Base Pairings | Coinspeaker
HybridExchange will go live in early June 2018 and will be one of the first exchanges to list TUSD as a base pairing, also ... Initial base pairings with TUSD will include BTC/TUSD, ETH/TUSD, LTC/TUSD, XRP/TUSD, and HYB/TUSD. ... TrueUSD will be utilized on HybridExchange to serve as a base pairing to allow traders to hedge against market volatility, ... HybridBlock Partners with TrustToken to Bring TrueUSD Stablecoin to Exchange Base Pairings. Place/Date: Singapore - May 29th, ...
Dayton Audio - SSMB24 24' Speaker Stand Pair Square Steel Base
Variable.Pair.Tbl · ocaml-base-compiler 4.12.1 · OCaml Packages
Montera Anthracite Gas Lift Bar Stool In Pair With Steel Base | Furniture in Fashion
OFDM Based Ethernet Transmission over Copper Twisted Pair Cables - IWCS Cable & Connectivity Industry Forum
Following the massive commercial deployment of 10G BASE-T and the development of 40G BASE-T, twisted pair based copper cable ... OFDM Based Ethernet Transmission over Copper Twisted Pair Cables. Speaker Bio: Beier Li, Ph.D. Student , De Montfort University ... In this talk, the three copper-based communication systems are introduced, and the OFDM modulation is discussed as a candidate ... The other major copper cable-based access network, the Data Over Cable Service Interface Specification (DOCSIS), has also ...
8.22: Brønsted-Lowry Acids and Bases: Conjugate Acid/Base Pairs - Chemistry LibreTexts
... is the conjugate acid of this base.. 8.22: Brønsted-Lowry Acids and Bases: Conjugate Acid/Base Pairs is shared under a not ... Bases%2F8.22%253A_Brnsted-Lowry_Acids_and_Bases%253A_Conjugate_Acid_Base_Pairs ... 8.22: Brønsted-Lowry Acids and Bases: Conjugate Acid/Base Pairs *. Last updated. ... Identify the conjugate acid/base pairs in a Brønsted-Lowry acid/base equation. ...
Hawk Talon Cross Drilled and Slotted Front Rotor Pair - Subaru Base 1993-1995 | HTC5138|Rallysport Direct
TrueUSD Is Now a Base Pair on Binance - Bitcoin Magazine - Bitcoin News, Articles and Expert Insights
... as a base currency, expanding the stablecoins available trading pairs. ... Malta-based cryptocurrency exchange Binance has added TrustTokens TrueUSD (TUSD) ... TrueUSD Is Now a Base Pair on Binance. Malta-based cryptocurrency exchange Binance has added TrustTokens TrueUSD (TUSD) as a ... Paxos Standard (PAX) Is Now a Base Pair on Binance. By Jimmy Aki. Nov 27, 2018. ...
Bachelor Canada: 5 wine-based beverages perfectly paired for finale
For the finale, we created five next-level wine-based beverages. ... Here are five next-level wine-based beverages perfectly paired ... As a special treat for The Bachelor Canada finale, we created five next-level wine-based beverages that pair perfectly with ... Home FOOD + DRINK, HOMEBachelor Canada: Five Wine-Based Beverages Perfectly Paired for the Finale ...
Erratum: "ABCNN: Attention-Based Convolutional Neural Network for Modeling Sentence Pairs" | Transactions of the Association...
Erratum: "ABCNN: Attention-Based Convolutional Neural Network for Modeling Sentence Pairs" Wenpeng Yin, Wenpeng Yin ... ABCNN: Attention-Based Convolutional Neural Network for Modeling Sentence Pairs Transactions of the Association for ... This is a correction to: ABCNN: Attention-Based Convolutional Neural Network for Modeling Sentence Pairs ... Wenpeng Yin, Hinrich Schütze, Bing Xiang, Bowen Zhou; Erratum: "ABCNN: Attention-Based Convolutional Neural Network for ...
565: ROBERT VENTURI, Urn-base dining tables, pair < Modern + Contemporary Design, 28 March 2006 < Auctions | Wright: Auctions...
Crystallization of a complex of cro repressor with a 17 base-pair operator. | [email protected]
Crystallization of a complex of cro repressor with a 17 base-pair operator. ... Crystallization of a complex of cro repressor with a 17 base-pair operator. Journal Article (Journal Article) ... Crystals of the lambda cro repressor complexed to a 17 base-pair synthetic binding site related to the OR3 operator have been ...
TACO Stainless Outrigger Base, Striker Pair, 1, 1/8', F16-0212-F
TACO Stainless Outrigger Base, Striker Pair, 1, 1/8", F16-0212-F. ... Striker Bases are the strongest flush mount bases on the market today and feature a patented hex nut locking mechanism that ... TACO 15 Telescopic Outrigger Poles 1-1/8", Black/Gold (Pair) TACO 15 Telescopic Outrigger Poles 1-1/8", Silver/Gold (Pair) OT ... Mounting base included. *Compatibile with TACO Marine 1-1/8" Tele-Outriggers and 1-1/8" outrigger poles from Lee , Perko , & ...
NucleotideSequencesBilinearCohort studyCryptographicWatson-CrickStrandsSequenceCryptographyAlgorithmDUPLEXMolecularChromosomeProtocolsAdenineEquationsAbstractTUSDNodesDownstreamCurrencyRectangularCorrelation coefficientClassificationCodonChromosomalGeneticTypeSegmentsStrandHydrogen bondsDesignSpecificQUALIFICATIONSInteractionsVeganDiagnosticsMeasurementsProcedureQuoteParticipantsOpioidImportantTimeHumanRecordingsRestriction enzymesBrooklynWorkStructuresSiteMinimalistPrimeProposePositionSchemeDataChapterSmallDiving boardCultureProgram
Nucleotide5
- Displays a graphical map based on nucleotide sequence data labeled with restriction enzymes, plasmid features, ORFs (theoretical open reading frames) and primers. (addgene.org)
- Displays both strands of base paired nucleotide sequences with annotated enzymes, plasmid features, ORFs (theoretical open reading frames) and primers. (addgene.org)
- Just like Velcro and magnets have complementary hooks or poles, the nucleotide bases of DNA pair up and bind in a predictable way. (astrobiology.com)
- Beginning in 1990 and finishing in 2003, the Human Genome Project was an international research initiative that aimed to write the entire sequence of nucleotide base pairs that make up the human genome, including the mapping of all its genes that determine our physical and functional attributes. (soci.org)
- The basic-level eLearning course provides information on the fundamental characteristics of DNA and RNA, nucleotide base-pairing rules, and the basic techniques and workflow applied in molecular diagnostics. (cdc.gov)
Sequences1
- We believe that those three independent pairing events each provide an opportunity to reject off-target sequences," he adds. (the-scientist.com)
Bilinear4
- first proposed a novel ID-based signature scheme without trusted PKG from bilinear pairings [10], i.e., there is only one PKG who is not assumed to be honest in their scheme. (sciweavers.org)
- In this paper we propose another ID-based signature scheme without trusted PKG from bilinear pairings. (sciweavers.org)
- Our constructions are based on a special type of algebraic group called bilinear groups. (dcu.ie)
- We present existing cryptographic constructions which use bilinear pairings, namely Identity-Based Encryption (IBE). (dcu.ie)
Cohort study2
- To determine contributions of previously incarcerated persons to tuberculosis (TB) transmission in the community, we performed a healthcare facility-based cohort study of TB patients in Thailand during 2017-2020. (cdc.gov)
- MATERIALS AND METHODS This was a prospective hospital-based paired cohort study. (bvsalud.org)
Cryptographic2
- Only recently after some pioneering works, particularly the well-known Boneh-Franklin identity-based encryption (IBE), pairings have quickly become an important tool to construct novel cryptographic schemes. (bl.uk)
- In this thesis, several new cryptographic schemes with pairings are proposed, which are both efficient and secure with respect to a properly defined security model, and some relevant previous schemes are revisited. (bl.uk)
Watson-Crick2
- Figure 1: KlenTaq polymerase induces the dNaM-d5SICS unnatural base pair to adopt a natural, Watson-Crick-like structure. (nature.com)
- Hopton, SR & Thompson, AS 2011, ' Manipulative interplay of two adozelesin molecules with d(ATTAAT) 2 achieving ligand-stacked Watson-Crick and Hoogsteen base-paired duplex adducts ', Biochemistry , vol. 50, no. 19, pp. 4143-4154. (bath.ac.uk)
Strands2
- Figure 5 As the two strands of the double helix unwind, each pairs up with the appropriate bases to form a new double helix. (wjgnet.com)
- In this work , we tested a polybutylene terephthalate (PBT)-bonded silica -based stationary phase for the separation of generically synthesized Patisiran as siRNA (antisense and sense single strands as well as their annealed double strand) giving some unexpected selectivity without any presence of ion-pairing reagents . (bvsalud.org)
Sequence8
- a ) Alignment results on sequence s a given by pairs p =〈 a , b 〉 and q =〈 a , c 〉. ( b ) The worst case that can be derived from the results. (biomedcentral.com)
- One of the adducts, formed with adozelesin and the d(ATTAAT)(2) sequence, also demonstrates the ability of these ligands to manipulate the DNA of the binding site, resulting in a Hoogsteen base-paired adduct. (bath.ac.uk)
- Primer location based on reference strain L 2 /434 16SrRNA sequence. (cdc.gov)
- Primer location based on position within intron 3 of the human β -actin sequence. (cdc.gov)
- Primer location based on position within exon 3 of the human β -actin sequence. (cdc.gov)
- Primer location based on intergenic region of reference strain L 2 /434 downstream of ompA sequence. (cdc.gov)
- It may now cost less to sequence the three billion DNA base pairs of a human genome than to do a brain scan. (nature.com)
- It uses the same Cas9 nuclease as frequently deployed in the CRISPR system but combines the enzyme with two new reagents: a guide RNA called pegRNA, which leads Cas9 to the desired spot in the genome, and a reverse transcriptase that initiates the addition of a new sequence or base into the genome. (the-scientist.com)
Cryptography1
- For a long time, pairings on elliptic curves have been considered to be destructive in elliptic curve cryptography. (bl.uk)
Algorithm2
- To achieve an overall high-quality result across all time steps in terms of stability and aspect ratio, SizePairs employs a new hierarchical size-based pairing algorithm that recursively pairs two nodes that complement their size changes over time and have similar sizes. (yunhaiwang.net)
- Algorithm improvements will include the use of spectral FFT-based methods for implementing a variety of Neuman and Dirichlet boundary conditions, as well as mixed, nonlinear and implicit boundaries in an arbitrary number of dimensions. (edu.au)
DUPLEX3
- DNA duplex, coded with A=T and G≡C base pairs, is well suited for biological information storage. (pku.edu.cn)
- The interactions between two bases in a base pair contribute to the stability of DNA duplex, and are further related to gene replication and transcription. (pku.edu.cn)
- Free Energy Calculation for Base Pair Dissociation in a DNA Duplex[J].Acta Phys. (pku.edu.cn)
Molecular2
- In this study, we use all-atom Molecular dynamics (MD) simulations combined with Umbrella sampling (US) method to determine the free energy profiles and explore the molecular details for base pair dissociations. (pku.edu.cn)
- Reif's lab is also beginning to work on DNA-based devices that could detect molecular signatures of particular types of cancer cells, and release substances that spur the immune system to fight back. (astrobiology.com)
Chromosome1
- The publicly funded $3bn project was able to map 99% of the human genome with 99.99% accuracy, which included its 3.2bn Mega-base pairs, 20,000 genes and 23 chromosome pairs, and has led to advancements in bioinformatics, personalised medicine and a deeper understanding of human evolution. (soci.org)
Protocols1
- Identity-based two-party key agreement protocols from pairings are also investigated. (bl.uk)
Adenine1
- A repeating unit of DNA consisting of one of four bases - adenine, guanine, cytosine, or thymine - attached to a phosphate-sugar group. (flashcardmachine.com)
Equations1
- This will require developing code to simulate the quantum computer, either using phase-space methods based on stochastic equations, or using more advanced algorithms. (edu.au)
Abstract2
- Article: Data pair selection for accurate classification based on information-theoretic metric learning Journal: Asian Journal of Management Science and Applications (AJMSA) 2017 Vol.3 No.1 pp.61 - 74 Abstract: Data classification is one of the main technique in data analysis which has become more and more important in various fields of business. (inderscience.com)
- abstract = "We determine the anisotropy of the spin-fluctuation-induced pairing gap on the Fermi surface of the FeAs-based superconductors as function of the exchange and Hund's coupling JH. (dundee.ac.uk)
TUSD3
- HybridExchange will go live in early June 2018 and will be one of the first exchanges to list TUSD as a base pairing, also known as a quote currency. (coinspeaker.com)
- Malta-based cryptocurrency exchange Binance has added TrustToken's TrueUSD (TUSD) as a base currency, expanding the stablecoin's available trading pairs. (bitcoinmagazine.com)
- Adding to TUSD's original BTC pair, Binance will add the following trading pairs: BNB/TUSD, ETH/TUSD, XRP/TUSD, EOS/TUSD and XLM/TUSD. (bitcoinmagazine.com)
Nodes2
- For smaller values of Hund's coupling incommensurate magnetic fluctuations yield an s ± -pairing state with line nodes. (dundee.ac.uk)
- Mesenteric fat, vessels and lymph nodes were resected en block with the ascending colon. (medscape.com)
Downstream1
- The newly released strand can in turn pair up with other complementary DNA molecules downstream in the circuit, creating a domino effect. (astrobiology.com)
Currency3
- Last month, Binance added PAX token as a base currency on its trading platform. (bitcoinmagazine.com)
- Dollar Based Currency Pairs US Dollar/Norw. (theice.com)
- currency pairs, based on market activity at the close of the 24 December 2013 U.S. session. (econintersect.com)
Rectangular2
- A PAIR OF CHINESE GREEN SOAPSTONE FIGURES of kylins seated on their haunches on waisted rectangular bases carved with drapery (slight chips), late 19th Century -- 6¾in. (christies.com)
- segments 8-12 pairs, rectangular or subsquare, 3-5 × ca. 3.5 mm, entire, apices rounded or rounded-truncate and with 2-4 blunt angles. (efloras.org)
Correlation coefficient2
- The PCR amplification efficiency (E) and correlation coefficient (R 2 ) were calculated based on the corresponding threshold cycle (C T ) of each dilution sample during 40 cycles of real-time PCR (95°C denaturation for 15 sec, 65°C anneal/extension for 60 sec). (cellsignal.com)
- Using a reference station pair, we statistically isolate time windows within each group based on the correlation coefficient between each 5-min CCF and the monthly stacked CCF. (cdc.gov)
Classification2
- One of the effective approaches for automatic classification is the k-nearest neighbour (kNN) method based on distances between data pairs, combining with the well-known distance metric learning. (inderscience.com)
- This paper considers a centroid-based classification method for paired data, which at the same time performs a supervised variable selection respecting the matched pairs design. (cas.cz)
Codon1
- We therefore studied the association of two polymorphisms--R353Q polymorphism at codon 353 involving the catalytic region and the 10 base pair [bp] insertion polymorphism involving the promoter region--with FVllc levels in 176 healthy Tunisians. (who.int)
Chromosomal1
- Base pair substitutions, insertions, deletions, and larger chromosomal changes may be included in mutational spectra. (cdc.gov)
Genetic4
- Evaluate impact of public health interventions to assess benefits and harms for subsets of the population based on genetic and genomic information. (cdc.gov)
- With data for more than 1,900 individuals affected by a range of genetic conditions, researchers compared facial phenotype-based diagnoses informed by 2D or 3D images in the European Journal of Human Genetics. (genomeweb.com)
- To avoid confusion, this condition is usually called 22q11.2 deletion syndrome, a description based on its underlying genetic cause. (medlineplus.gov)
- In the smallest repeating unit of the packaged genetic material, or chromatin, ~150 DNA base pairs wrap around a core of histone proteins, forming the nucleosome. (harvard.edu)
Type4
- Although this type of base pairing has been previously observed with the bisfunctional CPI analogue bizelesin, this is the first time that such an observation has been made with a monoalkylating nondimeric analogue. (bath.ac.uk)
- Nowadays, ion-pairing reversed-phase liquid chromatography (IP-RPLC) is the dominating generic method for the analysis of nucleic acid related compounds, such as antisense- oligonucleotides (ASO), small-interfering ribonucleic acid ( siRNA ) or other DNA or RNA type molecules and their conjugates. (bvsalud.org)
- My system at home is based around a pair of 1200's and a analogue dj type mixer. (diyaudio.com)
- Another type of gene editing that doesn't rely on DNA breaks and was thought to minimize inaccuracy is base editing , in which an enzyme can trade one DNA nuclease for another, but this strategy offers limited options as it can only make four of the 12 possible base pair changes, and some recent work has suggested it's not as precise as scientists first thought. (the-scientist.com)
Segments2
- When sequencing bacteria, conventional machines can decode short segments of 1,000 DNA base pairs at a time. (cdc.gov)
- A region of a DNA molecule that contains short segments of three to seven repeating base pairs. (flashcardmachine.com)
Strand4
- But while it is comparatively easy to make changes to the strand of DNA that serves as the blueprint for a given protein, it remains challenging to determine which specific base pairs - rungs on the DNA ladder - are the keys to producing a desired effect. (nanowerk.com)
- the switches are base pairs on the strand. (nanowerk.com)
- A new gene editing technique called prime editing, tested in human and mouse cells, rewrites DNA by only cutting a single strand to add, remove, or replace base pairs. (the-scientist.com)
- So building on what the two knew about base editing and CRISPR-Cas9, they began working on a new technique to cut just one strand of DNA, leaving the other intact. (the-scientist.com)
Hydrogen bonds2
- In the potential of mean force (PMF) profile for G≡C base pair dissociation (denoted as PMF-PGC), we observed three peaks, which correspond to the three moments G≡C base pair loses its three hydrogen bonds respectively. (pku.edu.cn)
- Differently, A=T base pair loses its two hydrogen bonds within a very short time. (pku.edu.cn)
Design3
- Together, these results provide a new model for the design of CPI-based antitumor antibiotics, which also has a significant bearing on other structurally related and structurally unrelated minor groove-binding ligands. (bath.ac.uk)
- The AIGA Orlando Mentorship Program pairs the most passionate design students with leading industry professionals to help refine their skills and prepare them for a career in a creative field. (aiga.org)
- Design, Setting, and Participants: Population-based cross-sectional analysis of opioid prescriptions filled nationwide at US retail pharmacies between January 1, 2006, and December 31, 2017. (cdc.gov)
Specific1
- The specific pairing of base A with T and base C with G in double-stranded DNA. (flashcardmachine.com)
QUALIFICATIONS1
- Applicants accepted into the program will be paired with professionals based on interest and qualifications. (aiga.org)
Interactions1
- The large number of histone-DNA interactions within a nucleosome would make its DNA largely inaccessible, turning the nucleosome into a roadblock to DNA-based transactions. (harvard.edu)
Vegan1
- As a vegan pair, their uppers either come in high-shine Oxford Rub Off or shine-free Felix Rub Off. (getvegan.com)
Diagnostics1
- This robustness makes the method relevant for genomic, metabolomic or proteomic high-dimensional data (in matched case-control studies) or medical diagnostics based on images, as (excessive) noise and contamination are ubiquitous in biomedical measurements. (cas.cz)
Measurements1
- In Chapter 4, graphene field-effect transistors (GFETs) are introduced for cesium ion sensing based on electrostatic measurements. (utexas.edu)
Procedure3
- ID-based public key systems allow the user to use his/her identity as the public key, which can simplify key management procedure compared with CA-based public key systems. (sciweavers.org)
- In this study, we propose an improved procedure by choosing the data-pairs which affect clarifying the boundaries effectively. (inderscience.com)
- A procedure used to determine the order of the base pairs that constitute DNA. (flashcardmachine.com)
Quote1
- Tory Reiss, co-founder of TrustToken, told Bitcoin Magazine that Binance chose TrueUSD as a quote pair due to the liquidity and trust that it is able to bring to the market. (bitcoinmagazine.com)
Participants2
- The current study used DNA samples from 1978 participants 66 to 101 years of age (mean age, 78.3 years), from the Washington Heights-Inwood Community Aging Project (WHICAP), a population-based study of aging and dementia. (medscape.com)
- Participants from 93 counties extracted data from multiple and diverse sources to quantify county demographics, health status, and resources and wrote problem statements based on the data examined. (cdc.gov)
Opioid1
- The objective of this analysis was to compare monthly trends in pharmacy-based dispensing rates of medications for opioid use disorder (MOUD) (buprenorphine and extended-release [ER] naltrexone) and naloxone in the United States during March 2019-December 2020 by age and sex. (cdc.gov)
Important1
- Please read below for important return au pair information. (aupairinamerica.com)
Time4
- Here are five next-level wine-based beverages perfectly paired with the best in prime time. (style.ca)
- To reflect the stability of each method, we assign colors to each rectangle (based on its position) at the first time step and then apply the color scheme to the other time steps (we mark three data items using shpaes to facilitate the comparison). (yunhaiwang.net)
- Maybe you were an au pair yourself at one time? (aupairinamerica.com)
- Con su primer singles ' Nick of Time' y con apenas 4 minutos de duracion, Tom y Jamie han creado una excelente mezcla de todo lo que querian hacer musicalmente, con todas sus influencias musicales mezcladas en una cancion pop con elementos de shoegaze, noise y dance. (sonicbids.com)
Human3
- The order of bases on all twenty-three pairs of human chromosomes. (flashcardmachine.com)
- Contact Pair and work with a real human working locally in our Pittsburgh-based facilities. (pair.com)
- Basically, they want to take all 3 billion base pairs in the human genome, program them into a machine and have the machine piece it all together. (kjrh.com)
Recordings3
- Tom Lugo is also a well-established personality in the shoegaze indie pop world, as the founder of Patetico Recordings, a small Philadelphia-based indie record label, and from having founded and been involved in numerous musical projects related to shoegaze, noise and independent music in general. (sonicbids.com)
- Tom Lugo es ya toda un personalidad en el mundo del shoegaze y el indie-pop, como fundador de Patetico Recordings, y por haber sido parte de de innumerables proyectos musicales relacionados con el shoegaze, el noise y la musica independiente en general. (sonicbids.com)
- Syntax Creative is pleased to announce a new partnership with both Krosswerdz Recordings and Unleashed Music, a pair of record labels based in Australia. (ccmmagazine.com)
Restriction enzymes1
- Different fragment lengths of base pairs that result from cutting a DNA molecule with restriction enzymes. (flashcardmachine.com)
Brooklyn1
- Ace Base is made by a Brooklyn based company with designs combining rustic and modern styles - a country aesthetic for urban spaces - using reclaimed & plantation raised woods, created in a sustainable and environmentally responsible manner. (sitdownny.com)
Work5
- This work serves to extend the fundamental chemistry of calix[4]arene-based cesium ion recognition to new research areas. (utexas.edu)
- Hire ASL Sign Language-Speaking Nanny, Babysitter, Au Pair or Tutor Seeking Jobs in Child Care or Service Work. (greataupair.com)
- Born as Android Wear, Wear OS is Google's Android-based operating system specifically designed to work on wearables and smartwatches . (androidauthority.com)
- The SPOT Showcase is the culmination of the AIGA Orlando Mentorship Program, where students are paired with mentors and work on a project over the course of several months. (aiga.org)
- This study evaluated the efficacy of an integrated Total Worker Health program, "All the Right Moves", designed to target the conditions of work and workers' health behaviors through an ergonomics program combined with a worksite-based health promotion HealthWeek intervention. (cdc.gov)
Structures2
- Many candidate unnatural DNA base pairs have been developed, but some of the best-replicated pairs adopt intercalated structures in free DNA that are difficult to reconcile with known mechanisms of polymerase recognition. (nature.com)
- Here we present crystal structures of KlenTaq DNA polymerase at different stages of replication for one such pair, dNaM-d5SICS, and show that efficient replication results from the polymerase itself, inducing the required natural-like structure. (nature.com)
Site2
- Crystals of the lambda cro repressor complexed to a 17 base-pair synthetic binding site related to the OR3 operator have been obtained. (duke.edu)
- The official Global Operations site sports a new pair of screenshots from this team-based tactical shooter in the works at Barking Dog. (bluesnews.com)
Minimalist1
- The Floor-to-Ceiling Hidden Base Plate is a minimalist version of the standard base plate, removing the connecting steel between supports. (beveragefactory.com)
Prime1
- If any one of those three DNA pairing events fail, then prime editing can't proceed," says Liu. (the-scientist.com)
Propose3
- Moreover, we propose an ID-based threshold signature scheme without trusted PKG, which sim. (sciweavers.org)
- In this study, we propose a new binding model for several of the CPI-based analogues, in which the aromatic secondary rings form pi-stacked complexes within the minor groove. (bath.ac.uk)
- In addition, we propose that DSB pairing will help develop more accurate alternatives to the linear cancer risk model (LNT) currently used for regulating exposure to very low levels of ionizing radiation. (escholarship.org)
Position3
- To put your headset in pair mode, slide and hold the Power switch away from the off position until you hear "pairing" and the headset LEDs flash red and blue. (headsetplus.com)
- That fuse position in the circuit is definitely not where a general safety fuse would be placed, so it would be reasonable to think it has a special function based on the circuit topology. (applefritter.com)
- The chromosomes are arranged in pairs, and aligned using the position of each chromosome's centromere. (cdc.gov)
Scheme1
- Based on the Sakai-Kasahara key construction, an IBE scheme which is secure in the Boneh-Franklin IBE model is constructed, and two identity-based key encapsulation mechanisms are proposed. (bl.uk)
Data4
- In ITML, the optimisation problem is formulated as learning metric matrix so that the distance between each pair of data belonging to the same class becomes smaller than a constant, while the distance between each pair of data belonging to different classes becomes larger than the other constant. (inderscience.com)
- The other major copper cable-based access network, the Data Over Cable Service Interface Specification (DOCSIS), has also adopted OFDM, where the extended frequency band causes degraded channel condition. (iwcs.org)
- Because of the sheer quantity of data involved, DNNs have been tasked with sorting through a sampling of data and predicting which base pairs need to be flipped. (nanowerk.com)
- Research organizations are assembling cloud-based 'information commons' to standardize, store and share the data ( S16 ). (nature.com)
Chapter2
- Chapter 1 describes an overview of sensitive ion selective chromogenic and fluoregenic sensors based on calix[4]arene derivatives. (utexas.edu)
- Mentors and mentees will be thoughtfully paired by our chapter board members following the application submission period. (aiga.org)
Small4
- We find that for sufficiently large JH, nearly commensurate magnetic fluctuations yield a fully gapped s±-pairing state with small anisotropy of the gap amplitude on each Fermi-surface sheet, but significant variations of the gap amplitude for different sheets of the Fermi surface. (dundee.ac.uk)
- Polybutylene terephthalate-based stationary phase for ion-pair-free reversed-phase liquid chromatography of small interfering RNA. (bvsalud.org)
- In September 2011 I somehow got the feeling that I just HAD to build a small Z80 based computer again. (vaxman.de)
- So I searched for useable parts in my hardware repository and found everything necessary to build a small (tiny, in fact) Z80 based computer. (vaxman.de)
Diving board2
- Pair the base with an upgraded color diving board for a sleek look to match your backyard décor. (poolsupplyunlimited.com)
- This is a complete 8' diving board kit including the base and board. (poolsupplyunlimited.com)
Culture1
- Completion of anti-TB therapy is based on the examination of sputum smear, culture, and chest radiographic results. (cdc.gov)
Program9
- Are you currently hosting an au pair on the Exchange Visitor Program from another agency? (aupairinamerica.com)
- If you have never tried Au Pair in America, apply for free and receive up to $350 off your program fee. (aupairinamerica.com)
- Our professional staff is on hand to explain the Au Pair in America program difference and provide unparalleled comprehensive support throughout the year. (aupairinamerica.com)
- If so, you apply for free at Au Pair in America and benefit from a standing $500 program fee discount. (aupairinamerica.com)
- If you or a member of your immediate family participated in another AIFS program you are entitled to receive a 5% program fee discount with Au Pair in America. (aupairinamerica.com)
- If you are an Au Pair in America participant interested in another AIFS program you will receive a 5% special discount and any AIFS program you choose. (aupairinamerica.com)
- In addition, should you and your au pair choose to stay together for a second year, your program fee is substantially reduced. (aupairinamerica.com)
- Save $350 off your program fee if one of your former au pairs returns to your family. (aupairinamerica.com)
- After controlling for matched intervention and control pairs as well as covariates, at one-month following the ergonomics program we observed a significant improvement in ergonomic practices (B = 0.20, p = 0.002), and a reduction in incidences of pain and injury (OR = 0.58, p = 0.012) in the intervention group. (cdc.gov)