Basal Nucleus of Meynert: A group of nerve cells in the SUBSTANTIA INNOMINATA that has wide projections to the NEOCORTEX and is rich in ACETYLCHOLINE and CHOLINE ACETYLTRANSFERASE. In PARKINSON DISEASE and ALZHEIMER DISEASE the nucleus undergoes degeneration.Substantia Innominata: Tissue in the BASAL FOREBRAIN inferior to the anterior perforated substance, and anterior to the GLOBUS PALLIDUS and ansa lenticularis. It contains the BASAL NUCLEUS OF MEYNERT.Amygdala: Almond-shaped group of basal nuclei anterior to the INFERIOR HORN OF THE LATERAL VENTRICLE of the TEMPORAL LOBE. The amygdala is part of the limbic system.Basal Ganglia: Large subcortical nuclear masses derived from the telencephalon and located in the basal regions of the cerebral hemispheres.Peanut Agglutinin: Lectin purified from peanuts (ARACHIS HYPOGAEA). It binds to poorly differentiated cells and terminally differentiated cells and is used in cell separation techniques.Glycoconjugates: Carbohydrates covalently linked to a nonsugar moiety (lipids or proteins). The major glycoconjugates are glycoproteins, glycopeptides, peptidoglycans, glycolipids, and lipopolysaccharides. (From Biochemical Nomenclature and Related Documents, 2d ed; From Principles of Biochemistry, 2d ed)Choline O-Acetyltransferase: An enzyme that catalyzes the formation of acetylcholine from acetyl-CoA and choline. EC 2.3.1.6.Neuropsychiatry: A subfield of psychiatry that emphasizes the somatic substructure on which mental operations and emotions are based, and the functional or organic disturbances of the central nervous system that give rise to, contribute to, or are associated with mental and emotional disorders. (From Campbell's Psychiatric Dictionary, 8th ed.)Cholinergic Fibers: Nerve fibers liberating acetylcholine at the synapse after an impulse.Cell Nucleus: Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)Neurons: The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.Prosencephalon: The anterior of the three primitive cerebral vesicles of the embryonic brain arising from the NEURAL TUBE. It subdivides to form DIENCEPHALON and TELENCEPHALON. (Stedmans Medical Dictionary, 27th ed)Acetylcholinesterase: An enzyme that catalyzes the hydrolysis of ACETYLCHOLINE to CHOLINE and acetate. In the CNS, this enzyme plays a role in the function of peripheral neuromuscular junctions. EC 3.1.1.7.Brain: The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)Cerebral Cortex: The thin layer of GRAY MATTER on the surface of the CEREBRAL HEMISPHERES that develops from the TELENCEPHALON and folds into gyri and sulchi. It reaches its highest development in humans and is responsible for intellectual faculties and higher mental functions.Nucleus Accumbens: Collection of pleomorphic cells in the caudal part of the anterior horn of the LATERAL VENTRICLE, in the region of the OLFACTORY TUBERCLE, lying between the head of the CAUDATE NUCLEUS and the ANTERIOR PERFORATED SUBSTANCE. It is part of the so-called VENTRAL STRIATUM, a composite structure considered part of the BASAL GANGLIA.Thalamic Nuclei: Several groups of nuclei in the thalamus that serve as the major relay centers for sensory impulses in the brain.Solitary Nucleus: GRAY MATTER located in the dorsomedial part of the MEDULLA OBLONGATA associated with the solitary tract. The solitary nucleus receives inputs from most organ systems including the terminations of the facial, glossopharyngeal, and vagus nerves. It is a major coordinator of AUTONOMIC NERVOUS SYSTEM regulation of cardiovascular, respiratory, gustatory, gastrointestinal, and chemoreceptive aspects of HOMEOSTASIS. The solitary nucleus is also notable for the large number of NEUROTRANSMITTERS which are found therein.Cochlear Nucleus: The brain stem nucleus that receives the central input from the cochlear nerve. The cochlear nucleus is located lateral and dorsolateral to the inferior cerebellar peduncles and is functionally divided into dorsal and ventral parts. It is tonotopically organized, performs the first stage of central auditory processing, and projects (directly or indirectly) to higher auditory areas including the superior olivary nuclei, the medial geniculi, the inferior colliculi, and the auditory cortex.Raphe Nuclei: Collections of small neurons centrally scattered among many fibers from the level of the TROCHLEAR NUCLEUS in the midbrain to the hypoglossal area in the MEDULLA OBLONGATA.Cerebellar Nuclei: Four clusters of neurons located deep within the WHITE MATTER of the CEREBELLUM, which are the nucleus dentatus, nucleus emboliformis, nucleus globosus, and nucleus fastigii.Septal Nuclei: Neural nuclei situated in the septal region. They have afferent and cholinergic efferent connections with a variety of FOREBRAIN and BRAIN STEM areas including the HIPPOCAMPAL FORMATION, the LATERAL HYPOTHALAMUS, the tegmentum, and the AMYGDALA. Included are the dorsal, lateral, medial, and triangular septal nuclei, septofimbrial nucleus, nucleus of diagonal band, nucleus of anterior commissure, and the nucleus of stria terminalis.Active Transport, Cell Nucleus: Gated transport mechanisms by which proteins or RNA are moved across the NUCLEAR MEMBRANE.Arcuate Nucleus: A nucleus located in the middle hypothalamus in the most ventral part of the third ventricle near the entrance of the infundibular recess. Its small cells are in close contact with the ependyma.Caudate Nucleus: Elongated gray mass of the neostriatum located adjacent to the lateral ventricle of the brain.Paraventricular Hypothalamic Nucleus: Nucleus in the anterior part of the HYPOTHALAMUS.Suprachiasmatic Nucleus: An ovoid densely packed collection of small cells of the anterior hypothalamus lying close to the midline in a shallow impression of the OPTIC CHIASM.Red Nucleus: A pinkish-yellow portion of the midbrain situated in the rostral mesencephalic tegmentum. It receives a large projection from the contralateral half of the CEREBELLUM via the superior cerebellar peduncle and a projection from the ipsilateral MOTOR CORTEX.Trigeminal Nuclei: Nuclei of the trigeminal nerve situated in the brain stem. They include the nucleus of the spinal trigeminal tract (TRIGEMINAL NUCLEUS, SPINAL), the principal sensory nucleus, the mesencephalic nucleus, and the motor nucleus.Subthalamic Nucleus: Lens-shaped structure on the inner aspect of the INTERNAL CAPSULE. The SUBTHALAMIC NUCLEUS and pathways traversing this region are concerned with the integration of somatic motor function.Supraoptic Nucleus: Hypothalamic nucleus overlying the beginning of the OPTIC TRACT.Limbic System: A set of forebrain structures common to all mammals that is defined functionally and anatomically. It is implicated in the higher integration of visceral, olfactory, and somatic information as well as homeostatic responses including fundamental survival behaviors (feeding, mating, emotion). For most authors, it includes the AMYGDALA; EPITHALAMUS; GYRUS CINGULI; hippocampal formation (see HIPPOCAMPUS); HYPOTHALAMUS; PARAHIPPOCAMPAL GYRUS; SEPTAL NUCLEI; anterior nuclear group of thalamus, and portions of the basal ganglia. (Parent, Carpenter's Human Neuroanatomy, 9th ed, p744; NeuroNames, http://rprcsgi.rprc.washington.edu/neuronames/index.html (September 2, 1998)).Cellular Phone: Analog or digital communications device in which the user has a wireless connection from a telephone to a nearby transmitter. It is termed cellular because the service area is divided into multiple "cells." As the user moves from one cell area to another, the call is transferred to the local transmitter.Mobile Applications: Computer programs or software installed on mobile electronic devices which support a wide range of functions and uses which include television, telephone, video, music, word processing, and Internet service.Computers, Handheld: A type of MICROCOMPUTER, sometimes called a personal digital assistant, that is very small and portable and fitting in a hand. They are convenient to use in clinical and other field situations for quick data management. They usually require docking with MICROCOMPUTERS for updates.Mamillary Bodies: A pair of nuclei and associated gray matter in the interpeduncular space rostral to the posterior perforated substance in the posterior hypothalamus.Ageusia: Complete or severe loss of the subjective sense of taste, frequently accompanied by OLFACTION DISORDERS.Rosmarinus: A plant genus of the LAMIACEAE family. It is known as a spice and medicinal plant.Diterpenes, Abietane: A group of DITERPENES cyclized into 3-ring PHENANTHRENES.Condiments: Aromatic substances added to food before or after cooking to enhance its flavor. These are usually of vegetable origin.Plant Extracts: Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.Lamiaceae: The mint plant family. They are characteristically aromatic, and many of them are cultivated for their oils. Most have square stems, opposite leaves, and two-lipped, open-mouthed, tubular corollas (united petals), with five-lobed, bell-like calyxes (united sepals).Salvia officinalis: A plant species of the Salvia genus known as a spice and medicinal plant.Luffa: A plant genus of the family CUCURBITACEAE known for the fruit which is the source of the luffa sponge and the seeds which contain luffin.Acetylcholine: A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.Databases, Chemical: Databases devoted to knowledge about specific chemicals.Terminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Receptors, Nicotinic: One of the two major classes of cholinergic receptors. Nicotinic receptors were originally distinguished by their preference for NICOTINE over MUSCARINE. They are generally divided into muscle-type and neuronal-type (previously ganglionic) based on pharmacology, and subunit composition of the receptors.Receptors, Cholinergic: Cell surface proteins that bind acetylcholine with high affinity and trigger intracellular changes influencing the behavior of cells. Cholinergic receptors are divided into two major classes, muscarinic and nicotinic, based originally on their affinity for nicotine and muscarine. Each group is further subdivided based on pharmacology, location, mode of action, and/or molecular biology.alpha7 Nicotinic Acetylcholine Receptor: A member of the NICOTINIC ACETYLCHOLINE RECEPTOR subfamily of the LIGAND-GATED ION CHANNEL family. It consists entirely of pentameric a7 subunits expressed in the CNS, autonomic nervous system, vascular system, lymphocytes and spleen.Databases, Pharmaceutical: Databases devoted to knowledge about PHARMACEUTICAL PRODUCTS.

Absence of a common functional denominator of visual disturbances in cerebellar disease. (1/111)

Several studies have demonstrated disturbances of visual perception in patients suffering from cerebellar disease. In an attempt to determine the cause of these visual disturbances and thereby the cerebellar contribution to vision, we designed two sets of experiments in which we tested (i) the possibility of a general magnocellular deficit in cerebellar disease and (ii) the alternative possibility of impaired spatial attention underlying visual disturbances in cerebellar patients. The first set of experiments consisted of a test of position discrimination, a parvocellular function and tests tapping different aspects of motion perception including speed discrimination, direction discrimination and the ability to extract a coherent motion signal embedded in noise. The second set of experiments compared the performance on two different classes of texture discrimination. The first one required fast and precise shifts of focal spatial attention ('serial search'), the second one, testing preattentive texture discrimination ('pop-out'), did not. In the first set of experiments cerebellar patients were impaired on the position discrimination task as well as several, albeit not all, tests of motion perception. The pattern of disturbances obtained was neither compatible with the notion of a selective magnocellular deficit nor the idea, originally put forward by Ivry and Diener (J Cogn Neurosci 1991; 3: 355-66) that visual deficits are secondary to an impaired measurement of time. In the second set of experiments, cerebellar patients showed normal performance on pop-out tasks and normal performance on all variants of the serial search task except for the one requiring comparison of a single element presented with a sample of the target in short-term memory. In summary, our results support the existence of visual disturbances in cerebellar disease, but provide evidence against a common, simple denominator such as a timing deficit, deficient cerebellar modulation of magnocellular circuitry, deficits of spatial attention or visual working memory.  (+info)

Stimulation of NMDA and AMPA receptors in the rat nucleus basalis of Meynert affects sleep. (2/111)

The nucleus basalis of Meynert (NBM), a heterogeneous area in the basal forebrain involved in the modulation of sleep and wakefulness, is rich in glutamate receptors, and glutamatergic fibers represent an important part of the input to this nucleus. With the use of unilateral infusions in the NBM, the effects of two different glutamatergic subtype agonists, namely N-methyl-D-aspartic acid (NMDA) and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) hydrobromide, on sleep and wakefulness parameters were determined in freely moving rats by means of polygraphic recordings. NMDA (5 nmol) and AMPA (0.4 nmol) induced an increase in wakefulness and an inhibition of slow-wave sleep. AMPA, but not NMDA, also caused a decrease in desynchronized sleep. These AMPA- and NMDA-mediated effects were counteracted by a pretreatment with the specific NMDA antagonist 2-amino-5-phosphonopentanoic acid (20 nmol) and the specific AMPA antagonist 6,7-dinitroquinoxaline-2,3-dione (2 nmol), respectively. The results reported here indicate that 1) the NBM activation of both NMDA and AMPA glutamate receptors exert a modulatory influence on sleep and wakefulness, and 2) AMPA, but not NMDA receptors, are involved in the modulation of desynchronized sleep, suggesting a different role for NBM NMDA and non-NMDA receptors in sleep modulation.  (+info)

Effects of the novel NMDA receptor antagonist gacyclidine on recovery from medial frontal cortex contusion injury in rats. (3/111)

Gacyclidine, a novel, noncompetitive NMDA receptor antagonist, was injected (i.v.) into rats at three different doses to determine if the drug could promote behavioral recovery and reduce the behavioral and anatomical impairments that occur after bilateral contusions of the medial frontal cortex (MFC). In the Morris water maze, contused rats treated with gacyclidine at a dosage of 0.1 mg/kg performed better than their vehicle-treated conspecifics. Rats given gacyclidine at either 0.3 or 0.03 mg/kg performed better than brain-injured controls, but not as well as those treated with 0.1 mg/kg. Counts of surviving neurons in the nucleus basalis magnocellularis (NBM) and the medial dorsal nucleus (MDN) of the thalamus were used to determine whether gacyclidine treatment attenuated secondary cell death. In both the NBM and the MDN, the counts revealed fewer surviving neurons in untreated contused rats than in gacyclidine-treated rats. Increases in the size and number of microglia and astrocytes were observed in the striatum of gacyclidine-treated contused brains. Although most consequences of MFC contusions were attenuated, we still observed increases in ventricle dilation and thinning of the cortex. In fact, the ventricles of rats treated with 0.1 mg/kg of gacyclidine were larger than those of their vehicle treated counterparts, although we observed no behavioral impairment.  (+info)

Developmental changes in the subcellular localization of calretinin. (4/111)

Brainstem auditory neurons in the chick nucleus magnocellularis (NM) express high levels of the neuron-specific calcium-binding protein calretinin (CR). CR has heretofore been considered a diffusible calcium buffer that is dispersed uniformly throughout the cytosol. Using high-resolution confocal microscopy and complementary biochemical analyses, we have found that during the development of NM neurons, CR changes from being expressed diffusely at low concentrations to being highly concentrated beneath the plasma membrane. This shift in CR localization occurs at the same time as the onset of spontaneous activity, synaptic transmission, and synapse refinement in NM. In the chick brainstem auditory pathway, this subcellular localization appears to occur only in NM neurons and only with respect to CR, because calmodulin remains diffusely expressed in NM. Biochemical analyses show the association of calretinin with the membrane is detergent-soluble and calcium-independent. Because these are highly active neurons with a large number of Ca2+-permeable synaptic AMPA receptors, we hypothesize that localization of CR beneath the plasma membrane is an adaptation to spatially restrict the calcium influxes.  (+info)

GABAergic inhibition in nucleus magnocellularis: implications for phase locking in the avian auditory brainstem. (5/111)

In the avian auditory brainstem, nucleus magnocellularis (NM) functions to relay phase-locked signals to nucleus laminaris for binaural coincidence detection. Although many studies have revealed that NM neurons exhibit intrinsic physiological and anatomical specializations for this purpose, the role of inhibition has not been fully explored. The present study characterizes the organization of GABAergic feedback to NM. Anterograde and retrograde labeling methods showed that NM receives a prominent projection from the ipsilateral superior olivary nucleus (SON). The functional features of this projection were explored in a brain slice preparation. Stimulating fibers from the SON evoked long-lasting, depolarizing responses in NM neurons that were blockable by bicuculline, a GABA(A) receptor antagonist. The slow time course of these responses allowed them to undergo temporal summation during repetitive stimulation. The summed GABAergic response was capable of blocking spikes generated in NM neurons by suprathreshold current injection. This inhibitory effect was attributable to a large reduction in input resistance caused by a combination of the opening of a GABAergic Cl(-) conductance and the recruitment of a low-voltage activated K(+) conductance. This large reduction of input resistance increased the amount of current necessary to drive NM neurons to threshold. The results lead us to propose that GABAergic inhibition enhances phase-locking fidelity of NM neurons, which is essential to binaural coincidence detection in nucleus laminaris.  (+info)

Electrophysiological properties of cholinergic and noncholinergic neurons in the ventral pallidal region of the nucleus basalis in rat brain slices. (6/111)

The ventral pallidum is a major source of output for ventral corticobasal ganglia circuits that function in translating motivationally relevant stimuli into adaptive behavioral responses. In this study, whole cell patch-clamp recordings were made from ventral pallidal neurons in brain slices from 6- to 18-day-old rats. Intracellular filling with biocytin was used to correlate the electrophysiological and morphological properties of cholinergic and noncholinergic neurons identified by choline acetyltransferase immunohistochemistry. Most cholinergic neurons had a large whole cell conductance and exhibited marked fast (i.e., anomalous) inward rectification. These cells typically did not fire spontaneously, had a hyperpolarized resting membrane potential, and also exhibited a prominent spike afterhyperpolarization (AHP) and strong spike accommodation. Noncholinergic neurons had a smaller whole cell conductance, and the majority of these cells exhibited marked time-dependent inward rectification that was due to an h-current. This current activated slowly over several hundred milliseconds at potentials more negative than -80 mV. Noncholinergic neurons fired tonically in regular or intermittent patterns, and two-thirds of the cells fired spontaneously. Depolarizing current injection in current clamp did not cause spike accommodation but markedly increased the firing frequency and in some cells also altered the pattern of firing. Spontaneous tetrodotoxin-sensitive GABA(A)-mediated inhibitory postsynaptic currents (IPSCs) were frequently recorded in noncholinergic neurons. These results show that cholinergic pallidal neurons have similar properties to magnocellular cholinergic neurons in other parts of the forebrain, except that they exhibit strong spike accommodation. Noncholinergic ventral pallidal neurons have large h-currents that could have a physiological role in determining the rate or pattern of firing of these cells.  (+info)

Pathological characteristic of Alzheimer's disease produced by lesion in nucleus basalis of Meynert in rats. (7/111)

OBJECTIVE: To find out if the lesion in nucleus basalis of Meynert (nbM) can induce some morphological changes characteristic of Alzheimer's disease. METHODS: Kainic acid was injected into nbM of the rats, and the behavioral deficiency and the morphological changes in the cortex and hippocampus were observed by methenamine silver staining and electron microscopical examination. RESULTS: After 9-15 months of breeding following nbM-lesion, we observed many pathological changes in this animal model, which were characteristic of Alzheimer's disease in human, and especially we could find for the first time the formation of senile plagues after 15-month breeding. CONCLUSION: It is proposed that the degeneration of nbM neurons might be primary and responsible for the pathological changes in other brain tissues in sporadic Alzheimer's disease.  (+info)

DNA replication precedes neuronal cell death in Alzheimer's disease. (8/111)

Alzheimer's disease (AD) is a devastating dementia of late life that is correlated with a region-specific neuronal cell loss. Despite progress in uncovering many of the factors that contribute to the etiology of the disease, the cause of the nerve cell death remains unknown. One promising theory is that the neurons degenerate because they reenter a lethal cell cycle. This theory receives support from immunocytochemical evidence for the reexpression of several cell cycle-related proteins. Direct proof for DNA replication, however, has been lacking. We report here the use of fluorescent in situ hybridization to examine the chromosomal complement of interphase neuronal nuclei in the adult human brain. We demonstrate that a significant fraction of the hippocampal pyramidal and basal forebrain neurons in AD have fully or partially replicated four separate genetic loci on three different chromosomes. Cells in unaffected regions of the AD brain or in the hippocampus of nondemented age-matched controls show no such anomalies. We conclude that the AD neurons complete a nearly full S phase, but because mitosis is not initiated, the cells remain tetraploid. Quantitative analysis indicates that the genetic imbalance persists for many months before the cells die, and we propose that this imbalance is the direct cause of the neuronal loss in Alzheimer's disease.  (+info)

*Acetylcholine

... basal ganglia and basal forebrain. Basal nucleus of Meynert acts mainly on M1 receptors in the neocortex. Medial septal nucleus ... In the basal forebrain, it originates from the basal nucleus of Meynert and medial septal nucleus: The ... An example of a central cholinergic area is the nucleus basalis of Meynert in the basal forebrain. The enzyme ... "Learning impairment following lesion of the basal nucleus of Meynert in the marmoset: modification by cholinergic drugs". Brain ...

*Braak staging

The latter half of this stage involves disease progression into the basal nucleus of Meynert, a cluster of acetylcholine-rich ... In particular, the dorsal motor nucleus of the vagus nerve in the medulla oblongata and anterior olfactory nucleus are affected ... Stage 2 is characterized by additional lesions in the raphe nuclei and gigantocellular reticular nucleus of the medulla ... Cell death can be observed in the substantia nigra, the dorsal motor nucleus of the vagus nerve, the gigantocellular reticular ...

*Dementia with Lewy bodies

A loss of acetylcholine-producing neurons (in the basal nucleus of Meynert and elsewhere) similar to that seen in Alzheimer's ...

*Hippocampus anatomy

... the substantia innominata and the basal nucleus of Meynert, the thalamus (including the anterior nuclear complex, the ... the raphe nuclei (the nucleus centralis superior and the dorsal raphe nucleus), the nucleus reticularis tegementi pontis, the ... laterodorsal nucleus, the paraventricular and parataenial nuclei, the nucleus reuniens, and the nucleus centralis medialis), ... The basal dendrites of Pyramidal neurons are also found here, where they receive input from other Pyramidal cells, septal ...

*NBM

... national beauty pageant of Mexico Basal nucleus of meynert, a nucleus of nerve cells in the brain NetBeans Module, a software ...

*List of MeSH codes (A08)

... basal nucleus of meynert MeSH A08.186.211.730.885.213 --- cerebral cortex MeSH A08.186.211.730.885.213.270 --- frontal lobe ... vestibular nucleus, lateral MeSH A08.186.211.132.810.507 --- raphe nuclei MeSH A08.186.211.132.931 --- trigeminal nuclei MeSH ... ventral thalamic nuclei MeSH A08.186.211.730.885 --- telencephalon MeSH A08.186.211.730.885.105 --- basal ganglia MeSH A08.186. ... midline thalamic nuclei MeSH A08.186.211.730.385.826.701.700 --- posterior thalamic nuclei MeSH A08.186.211.730.385.826.701.900 ...

*Theodor Meynert

... including the basal optic nucleus of Meynert, the substantia innominata of Meynert and "Meynert cells", which are solitary ... Meynert later distanced himself from Freud because of the latter's involvement with practices such as hypnosis. Meynert also ... Theodor Meynert Mental Illness as a "Brain Disease" Dorlands Medical Dictionary Theodor Hermann Meynert @ Who Named It List of ... Meynert's work was an important influence in the career of German neuropathologist Paul Flechsig (1847-1929). Meynert's work ...

*Index of anatomy articles

... socket joint band of Baillarger Bartholin's gland basal cistern basal forebrain basal ganglia basalis nucleus of Meynert basal ... notochord nuchal ligament nucleus nucleus accumbens nucleus ambiguus nucleus fastigius nucleus of Luys nucleus pulposus nucleus ... soleus solitary nucleus solitary tract somatic somatic motor nuclei somite spasm spasticity specific sensory nucleus of ... lateral cuneate nucleus lateral dorsal nucleus of thalamus lateral fissure lateral funiculus lateral geniculate body or nucleus ...

*TBR1

... of basal forebrain cholinergic neurons in the nucleus basalis of Meynert and horizontal limb of the diagonal band nucleus". ... Prenatal cocaine exposure in a mouse model caused a decrease in both GABA neuron migration from the basal to the dorsal ... Other regions of Tbr1 expression are: the olfactory bulbs and olfactory nuclei, the lateral hypothalamus region, the ... Tbr1 is localized in the nucleus where the cell's DNA is located. Tbr1 is expressed in glutamergic neurons rather than ...

*Neurotransmitter

The basal forebrain cholinergic nuclei are comprised the medial septal nucleus (Ch1), the vertical nucleus of the diagonal band ... and the nucleus basalis of Meynert (Ch4). Brainstem cholinergic nuclei include the pedunculopontine nucleus (Ch5), the ... The rostral nuclei, which include the nucleus linearis, dorsal raphe, medial raphe, and raphe pontis, innervate most of the ... and related brainstem nuclei; the serotonergic neurons originate from the raphe nuclei within the brainstem as well; the ...

*Nucleus basalis

The nucleus basalis, also nucleus basalis of Meynert is a group of neurons in the substantia innominata of the basal forebrain ... The nucleus basalis is inferior to the globus pallidus and within an area known as the substantia innominata. The nucleus is ... In this way activation of Nucleus Basalis promotes (A) and inhibits (B) thus allowing full attention to be paid to the new ... It is named after Theodor Meynert. NBM in relation to the globus pallidus and putamen - very low magnification. NBM - very high ...

*Amygdalofugal pathway

... the medial dorsal nucleus of the thalamus, the hypothalamus, the basal forebrain, the brain stem, septal nuclei and nucleus ... projections from the nucleus basalis of Meynert. Stimulation of the basolateral nucleus causes a reduction in feeding, and ... lateral nucleus, and the basomedial nucleus. The basolateral nucleus cooperates with the central nucleus in persistent fear ... the basolateral nucleus is more like the cerebral cortex than is the central nucleus. The basolateral nucleus differs from the ...

*Substantia innominata

It is part of the basal forebrain and includes the nucleus basalis. It consists of three layers, superior, middle, and inferior ... The substantia innominata also substantia innominata of Meynert (Latin for unnamed substance) is a stratum in the human brain ... The superior layer is named the ansa lenticularis, and its fibers, derived from the medullary lamina of the lentiform nucleus, ... pass medially to end in the thalamus and subthalamic region, while others are said to end in the tegmentum and red nucleus. The ...

*Gabriel Anton

In 1887 he traveled to Vienna in order to work with Theodor Meynert (1833-1892), who was to become an important influence to ... In his research of chorea, he identified scars in the lenticular nuclei. Iron Cross, 2nd class Red Cross Medal, 3rd class ... He is primarily remembered for his studies of psychiatric conditions arising from damage to the cerebral cortex and the basal ...

*Oskar Vogt

The Vogts greatly contributed to the analysis of what is known today as the basal ganglia system. Their main interest was on ... Based on their cytoarchitectonic studies, they promoted a six-layer pattern (there were 5 for Meynert and 7 for Cajal). Oskar ... She distinguished from back to front the lemnical radiation and a particular nucleus, in front of it the cerebellar ( ... This was including the caudate nucleus, the putamen and the fundus. The Vogt-Vogt syndrome is an extrapyramidal disturbance ...

*Sleep and memory

"Nerve growth factor promotes survival of cultured magnocellular cholinergic neurons from nucleus basalis of Meynert in ... In regards to NGF, the basal forebrain (production and distribution of AcH in the brain), more specifically the medial septal ... When functional connectivity was analyzed it was found that the dentate nucleus was more closely involved with the functions of ... Peigneux et al., 2006, reported that the lateral geniculate nucleus and occipital cortex display higher levels of activity ...
A unilateral ibotenic acid lesion was placed in the nucleus basalis magnocellularis of 3- and 18-month-old rats. In the lesioned aging rats, the number of choline acetyltransferase-immunoreactive neurons of the nucleus basalis magnocellularis was markedly reduced in the ipsilateral side and to a lesser extent in the contralateral side. Twenty-one days after the lesion, the activity of choline acetyltransferase in the ipsilateral cortex was reduced by 40% in both groups of rats and by 24% in the contralateral frontal cortex of the aging rats. Intracerebroventricular administration of nerve growth factor (10 micrograms twice a week) to aging lesioned rats for 3 weeks after surgery resulted in a complete recovery in the number of choline acetyltransferase-immunoreactive neurons in the nucleus basalis of both sides, and choline acetyltransferase activity in the contralateral cortex, with little effect on the ipsilateral cortex. No potentiation was seen after the concurrent administration of GM1 ...
This chapter presents evidence that (a) the dentate gyrus (DG) has at least three major functions, including conjunctive encoding of multiple sensory inputs, spatial pattern separation, and facilitation of encoding of spatial information; (b) the CA3 has at least three major functions, including short-term memory and rapid encoding, arbitrary associations, and pattern completion; and (c) the CA1 has at least four major functions, including temporal processing of information (temporal order memory), association across time, intermediate memory, and consolidation of new information. It presents additional evidence demonstrating that there are dissociations and associations between the DG and CA3. The dominant view of the relationship between CA3 and CA1 and short-term and intermediate-term memory is that they operate as a feed-forward sequential processing system. The more recent data, however, suggest that, for certain tasks, there are dissociations between short-term and intermediate-term memory ...
Introduction. Alzheimers disease (AD) is the most common type of dementia. It represents more than half the prevalence of dementia in the Brazilian elderly population1. The main characteristic of this type of neurodegenerative process is cognitive impairment that can lead to the onset of neuropsychiatric symptoms2. This neuropathological process indicates a specific loss of cholinergic neurons in the nucleus basalis of Meynert at the ventral surface of the basal forebrain. This neuropathological process indicates a specific loss of cholinergic neurons in the nucleus basalis of Meynert at the ventral surface of the basal forebrain. The reduction on cholinergic activity could affects and impairs cognitive function and behavior. A reduction in signal intensity in the area corresponding to the anterior lateral nucleus basalis has been significantly correlated with a reduced concentration of grey matter in the bilateral prefrontal cortex, inferior parietal lobule, and cingulate gyrus3.. Most studies ...
Background: Alzheimer's disease is a neurodegenerative disorder that is diagnosed with a lack of memory and perception. Objective: The aim of this study was to evaluate the effect of donepezil and folic acid on reference and working memory disorders caused by electrical lesion of nucleus basalis magnocellularis (NBM). Methods: In this experimental ...
These transgenic mice overexpress mutant human APP at levels approximately 5-fold higher than endogenous murine APP. As the mouse ages, levels of human Aβ40 and Aβ42 increase, with Aβ42 being the more prevalent species (Chishti et al., 2001). These mice develop early plaque formation with thioflavin S-positive amyloid deposits observed at three months and dense-cored plaques with neuritic pathology by five months, becoming more extensive with advanced age. Activated microglia appear concurrently with plaques and GFAP-positive astrocytes follow later, starting about 13-14 weeks (Dudal et al., 2004). Dystrophic neurites are also observed (Dudal et al., 2004; Woodhouse et al., 2009). There is a decrease in the number of cholinergic neurons in the nucleus basalis magnocellularis as measured by ChAT immunoreactivity (Bellucci et al., 2006) and loss of glutamic acid decarboxylase (GAD)-immunoreactive GABAergic neurons (Krantic et al., 2012).. Behaviorally, these mice show a variety of ...
This is a Phase I clinical study to assess the safety, tolerability and biologic activity of in vivo AAV-mediated delivery of CERE-110. Up to 12 subjects will receive open label CERE-110 in dose-escalating fashion. All subjects will receive bilateral, stereotactic injections of CERE-110 for a total of four (Dose A and B) and six (Dose C) injections to target the basal forebrain region of the brain containing the nucleus basalis of Meynert (NBM). All study participants will be observed for a 24-month period and then followed annually ...
Die pathologische Anatomie des erblichen manisch-depressiven Irreseins ist unbekannt Mannigfache Theorien bezüglich des Wesens der zirkulären Psychose sind erörtert worden. So hat Meynert1889 die...
Teaching spelling and vocabulary is easy with VocabularySpellingCity! Students can study and learn their word lists using vocabulary and spelling learning activities and games. Students can take final or practice spelling and vocabulary tests right on this engaging site. Premium games and automated student record keeping are available to Premium Members.
Looking for online definition of fountain decussation of Meynert in the Medical Dictionary? fountain decussation of Meynert explanation free. What is fountain decussation of Meynert? Meaning of fountain decussation of Meynert medical term. What does fountain decussation of Meynert mean?
Abell F, Krams M, Ashburner J, Passingham R, Friston K, Frackowiak R, Happe F, Frith C, Frith U (1999). The neuroanatomy of autism A voxel based whole brain analysis of structural scans. Neuroreport 10 1647-1651. Abitbol M, Menini C, Delezoide AL, Rhyner T, Vekemans M, Mallet J (1993). Nucleus basalis magnocellularis and hippocampus are the major sites of FMR-1 expression in the human fetal brain. Nat Genet 4 147-153. Alaghband-Rad J, McKenna K, Gordon CT, Albus KE, Hamburger SD, Rumsey JM,.... ...
Note: Neurolex imports many terms and their ids from existing community ontologies, e.g., the Gene Ontology. Neurolex, however, is a dynamic site and any content beyond the identifier should not be presumed to reflect the content or views of the source ontology. Users should consult with the authoritative source for each ontology for current information ...
only Disease Surveillance maschinenteile teil 1 1986; Response( CSR): statistical Acute Respiratory Syndrome( SARS). Zambon M: different initial basic maschinenteile was. Chan-Yeung M, Yu maschinenteile teil 1 1986: evaluation of selected sexual behavioral memory in Hong Kong pulmonary Administrative Region: learning mengungkapkan.
Cognitive impairments in humans and animals have been linked to dysfunction of neurons in the basal forebrain cholinergic system (BFCS). Degeneration of these cells may be, in part, responsible for some of the cognitive deficits observed in Alzheimers disease (AD). Although memory deficits are associated with lesions of the BFCS in rats, impairments in memory have been more subtle following similar lesions in monkeys. To evaluate the effects of BFCS lesions on cognitive processes in monkeys, we have systematically investigated the behavioral effects of ibotenic acid injections in the medial septum, nucleus of the diagonal band of Broca, and nucleus basalis of Meynert in cynomolgus monkeys, using a large series of cognitive tasks that examined different mnemonic and attentional abilities. These lesions did not impair accuracy in delayed nonmatching-to-sample, delayed response, simple or concurrent visual discriminations, spatial discriminations, or discrimination reversals. However, these ...
A behavioral memorys lifetime represents multiple molecular lifetimes, suggesting the necessity for a self-perpetuating signal. One candidate is DNA methylation, a transcriptional repression mechanism that maintains cellular memory throughout development. We found that persistent, gene-specific cortical hypermethylation was induced in rats by a single, hippocampus-dependent associative learning experience and pharmacologic inhibition of methylation 1 month after learning disrupted remote memory. We propose that the adult brain utilizes DNA methylation to preserve long-lasting memories ...
Substantia Innominata, part of the limbic system, is the tissue in the base of the forebrain which contains the basal nucleus of meynert
Ultrafast and temporally precise action potentials (APs) are biophysical specializations of auditory brainstem neurons; properties necessary for encoding sound localization and communication cues. Fundamental to these specializations are voltage dependent potassium (KV) and sodium (NaV) ion channels. Here we characterized the functional development of these ion channels and quantified how they shape AP properties in the avian cochlear nucleus magnocellularis (NM). We report that late developing NM neurons (embryonic [E] days 19-21) generate fast APs that reliably phase lock to sinusoidal inputs at 75 Hz. In contrast, early developing neurons (E19) contained NaV channels that inactivate at more negative voltages, suggesting alterations in NaV channel subtypes. Taken together, our results indicate that the refinement of passive and active ion channel properties operate differentially in order to develop fast and reliable APs in the avian NM.
Rationale The reasoned action approach (RAA) is a social cognitive model that outlines the determinants of intentional behavior. Primary and meta-analytic studies support RAA predictions for multiple health behaviors. However, including past behavior as a predictor in the RAA may attenuate model effects. Direct effects of past behavior on behavior may reflect non-conscious processes whereas indirect effects of past behavior through social cognitive variables may represent reasoned processes. Objective The present study extended a previous meta-analysis of the RAA by including effects of past behavior. The analysis also tested effects of candidate moderators of model predictions: behavioral frequency, behavior type, and measurement lag. Method We augmented a previous meta-analytic data set with correlations between model constructs and past behavior. We tested RAA models that included and excluded past behavior using meta-analytic structural equation modeling and compared the effects. Separate ...
Mark Tuszynski, at the University of California, San Diego, explores the potential of delivering nerve growth factor specifically to cholinergic neurons of the forebrains nucleus basalis to protect neurons against degeneration in Alzheimer disease. Tuszynski has for years persisted against skeptics who maintain that his method of choice-gene therapy in the brain-is not ready for prime time, too dangerous, too expensive, and too high-tech. All of that might be so, except the approach looks like it might just work. That, at least, is where things stand currently.. Tuszynski noted that prior work on models ranging from aging to injury, excitotoxicity, and amyloid overexpression all substantiate the rationale of using nerve growth factor in an effort to stem neuronal death and support repair. The leap to success in humans, Tuszynski believes, hinges on delivering this potent agent to its designated area but nowhere else. Last year, Alzforum covered formal publication of phase 1 results, to 22 ...
Note: Neurolex imports many terms and their ids from existing community ontologies, e.g., the Gene Ontology. Neurolex, however, is a dynamic site and any content beyond the identifier should not be presumed to reflect the content or views of the source ontology. Users should consult with the authoritative source for each ontology for current information ...
Looking for online definition of basal nuclei in the Medical Dictionary? basal nuclei explanation free. What is basal nuclei? Meaning of basal nuclei medical term. What does basal nuclei mean?
www.MOLUNA.de Molecular Neurosurgery with Targeted Toxins [4221446] - Introduction to Molecular NeurosurgerynRonald G. Wiley and Douglas A. LappinRibosome-Inactivating ProteinsnFiorenzo StirpenBiochemical, Physiological, and Behavioral Characterizations of the Cholinergic Basal Forebrain Lesion Produced by 192 IgG-SaporinnJerene J. WaitenBasal Forebrain Cholinergic Lesion by 192 IgG-Saporin: A Tool to Assess the Consequences of Cortical Cholinergic Dysfunction in Alzheimer s DiseasenReinhard Schliebsn192 IgG-Saporin-Induced
Woolf, N.J. (1996) The critical role of cholinergic basal forebrain neurons in morphological change and memory encoding A hypothesis. Neurobiology of Learning and Memory, 66, 258-266.
AD is a progressive neurodegenerative disease characterized by the loss of cholinergic neurons in the nucleus basalis of Meynert, which is the basement of the cholinergic hypothesis and results in the subsequent development of acetylcholinesterase (AChE) inhibitors in AD treatment [9]. AChE inhibitors are used to treat the patients with mild to moderate AD [10]. Since Donepezil can upregulate AChE activities significantly and increase the protein level of CSF in the patients with AD [11], it has been widely used in the symptomatic treatments of AD [12]. Many clinical trials have demonstrated that donepezil improves the patients cognition and some of the BPSD. These improvements of the patients can also reduce caregivers burden [13]. In this research, after patients with mild to moderate AD took donepezil 5-10 mg/d for 20 weeks, marked improvements were found in the daily activities, abnormal behaviors and psychiatric symptoms. Although the cognition of the patients was improved shortly at the ...
A more direct method than the usual ones for obtaining inhibitory gradients requires that the dimension of the nonreinforced stimulus selected for testing be orthogonal to the dimensions of the reinforced stimulus. In that case, the test points along
Downloadable (with restrictions)! Information is often embedded in memorable contexts, which may cue the asymmetric recall of similar past news through associative memory. We design a theory-driven experiment, in which participants observe signals about hypothetical companies. Here, identical signal realizations are communicated with identical contexts: stories and images. Because participants asymmetrically remember those past signals that get cued by the current context, beliefs systematically overreact. This overreaction depends in predictable ways on the signal history; the correlation between signals and contexts; and the scope for forgetting and associative memory. We quantify these results by structurally estimating a model of associative recall.
Rats were submitted to intra-structures injection of 192 IgG-saporin and then behaviorally tested 1 month and 1 year post-lesion in a nonmatching-to-position task. After achieving a complete objective response, how does cialis work the patient received consolidation with high dose BEAM ...
Gericke, CA, Lang, UE, Steckler, T, Schulze, G, Bajbouj, M and Hellweg, R (2003) Nerve growth factor response to excitotoxic lesion of the cholinergic basal forebrain is slightly impaired in aged rats. Journal of Neural Transmission, 110 6: 627-639. doi:10.1007/s00702-002-0819-z ...
Discover Lifes page about the biology, natural history, ecology, identification and distribution of Scoparia basalis, Many-spotted Scoparia Moth, maybe image
MS/nDB - Medial Septum/Nucleus of the Diagonal Band. Looking for abbreviations of MS/nDB? It is Medial Septum/Nucleus of the Diagonal Band. Medial Septum/Nucleus of the Diagonal Band listed as MS/nDB
A plurality of devices for processing IF-THEN JOIN operation of IF-THEN rules are provided to process the JOIN operation in a pipe-line manner. A JOIN operation processing facility has an input buffer for latching status data corresponding to one condition in a certain rule; an associative memory for latching status data corresponding to another condition; an output buffer for latching the result of a JOIN operation; and a data combining arrangement for replacing an item value from the two data by a meaningful value to generate one data so that a series of operations of picking up the data one by one from the input buffer, retrieving associatively the data of the associative memory by using the data picked up as a retrieval data and the common item as a retrieval key, and storing in the output buffer the combined result of the data picked up and the retrieval data.

Substantia Innominata  < Limbic System  << Brain (Encephalon)  <<< Central Nervous System (CNS)  @...Substantia Innominata < Limbic System << Brain (Encephalon) <<< Central Nervous System (CNS) @...

... is the tissue in the base of the forebrain which contains the basal nucleus of meynert ... which contains the basal nucleus of meynert. * ... basal forebrain), inferior to the anterior perforated substance ...
more infohttp://wellnessadvocate.com/?dgl=9355

Large Neurons in the Neostriatum and Basal Nucleus of Meynert: Simultaneous Decrease in Alzheimers Disease | SpringerLinkLarge Neurons in the Neostriatum and Basal Nucleus of Meynert: Simultaneous Decrease in Alzheimer's Disease | SpringerLink

... and are present in the basal nucleus of Meynert (bnM), hypothalamus, and tegmental nuclei of the rostral brain stem. ... Oyanagi K., Takahashi H., Wakabayashi K., Ikuta F. (1990) Large Neurons in the Neostriatum and Basal Nucleus of Meynert: ... Large Neurons in the Neostriatum and Basal Nucleus of Meynert: Simultaneous Decrease in Alzheimers Disease. ... Correlative decrease of large neurons in the neostriatum and basal nucleus of Meynert in Alzheimers disease, Brain Research ( ...
more infohttps://link.springer.com/chapter/10.1007/978-1-4684-5844-2_72

5/28- Limbic System Flashcards by Kathryn Kudlaty | Brainscape5/28- Limbic System Flashcards by Kathryn Kudlaty | Brainscape

Substantia innominata (involves basal nucleus of Meynert). - Septal area (near septum pallucidum) ... nucleus of thalamus sends projections to cingulate gyrus. - Then from cingulate gyrus back through entorrhinal cortex back to ... Cholinergic nucleus that projects to widespread areas of cortex and limbic system ... Corticomedial group to the medial hypothalamus via stria terminalis (directly or via bed nuclei) ...
more infohttps://www.brainscape.com/flashcards/5-28-limbic-system-3887178/packs/5694976

Sex differences in the neural and behavioral response to intranasal oxytocin and vasopressin during human social interaction.  ...Sex differences in the neural and behavioral response to intranasal oxytocin and vasopressin during human social interaction. ...

ac = anterior commissure; B = basal nucleus of Meynert; ic = internal capsule; LSV = lateral septal nucleus; LV = lateral ... ventricle; MS = medial septal nucleus; VDB = nucleus of the vertical limb of the diagonal band. Images are thresholded at p, ... basal forebrain, insula, amygdala and hippocampus), whereas OT and AVP either had no effect or in some cases actually decreased ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/?term=Sex+differences+in+the+neural+and+behavioral+response+to+intranasal+oxytocin+and+vasopressin+during+human+social+interaction

Clinical Trial to Evaluate the Efficacy and Security of Deep Brain Stimulation in Alzheimer´s Disease - Full Text View -...Clinical Trial to Evaluate the Efficacy and Security of Deep Brain Stimulation in Alzheimer´s Disease - Full Text View -...

Deep brain stimulation at Basal nucleus of Meynert. Device: Deep brain stimulation (Basal nucleus of Meynert) Deep brain ... Device: Deep brain stimulation (fornix) Device: Deep brain stimulation (Basal nucleus of Meynert) Not Applicable ... Experimental: Deep brain stimulation (Basal nucleus of Meynert) ... fornix and Basal nucleus of Meynert (BNM). To achieve this, a ...
more infohttps://clinicaltrials.gov/ct2/show/NCT03290274

Clinical Trial to Evaluate the Efficacy and Security of Deep Brain Stimulation in Alzheimer´s Disease - Full Text View -...Clinical Trial to Evaluate the Efficacy and Security of Deep Brain Stimulation in Alzheimer´s Disease - Full Text View -...

Deep brain stimulation at Basal nucleus of Meynert. Device: Deep brain stimulation (Basal nucleus of Meynert) Deep brain ... Device: Deep brain stimulation (fornix) Device: Deep brain stimulation (Basal nucleus of Meynert) Not Applicable ... Experimental: Deep brain stimulation (Basal nucleus of Meynert) ... fornix and Basal nucleus of Meynert (BNM). To achieve this, a ...
more infohttps://clinicaltrials.gov/ct2/show/NCT03290274?term=deep+brain+stimulation&rank=6

Plus itPlus it

B, Basal nucleus of Meynert; SS, substantia innominata. Definitions apply to all figures. ... this multifaceted system also targets various basal forebrain limbic nuclei, as well as extrastriatal basal ganglia structures ... lateral parabrachial nucleus; MPB, medial parabrachial nucleus; PnO, pontine reticular nucleus, oral part; scp, superior ... We also provide direct evidence for a midbrain projection to the STN and GP, two pivotal basal ganglia nuclei. This finding ...
more infohttp://www.jneurosci.org/content/21/18/7247

Copy of brain plasticity by Ramjoti Kaur on PreziCopy of brain plasticity by Ramjoti Kaur on Prezi

basal nucleus of Meynert). 전뇌 기저부 무명질(substantia innominata)에 있으며 이 부분의 신경원은 신경전달물질로 아세틸콜린(acetylcholine)을 함유하고 있고 치매의 일종인 ...
more infohttps://prezi.com/eoh3kssop56d/copy-of-brain-plasticity/

1 Reticular Formation Flashcards by Tye Bauserman | Brainscape1 Reticular Formation Flashcards by Tye Bauserman | Brainscape

Cholinergic neurons found in the basal forebrain; basal nucleus (of meynert) & Part of RF = dorsolateral pontine tegmentum. ... Input to supratrigeminal nucleus may be from basal ganglia, lateral hypothalamus and central nucleus of the Amygdala. ... solitary nucleus (memory enhancement) Rostral Pons. - Locus Ceruleus. - Cortex (arousal ) vigilance and attention.. - ... The midbrain raphe nuclei up to all regions of the cortex do what? ...
more infohttps://www.brainscape.com/flashcards/1-reticular-formation-3599157/packs/5463397

Regional heterogeneity of choline acetyltransferase activity in primate neocortex<...Regional heterogeneity of choline acetyltransferase activity in primate neocortex<...

... large differences in the density of innervation in different regions of primate neocortex by the nucleus basalis of Meynert. ... large differences in the density of innervation in different regions of primate neocortex by the nucleus basalis of Meynert.", ... large differences in the density of innervation in different regions of primate neocortex by the nucleus basalis of Meynert. ... large differences in the density of innervation in different regions of primate neocortex by the nucleus basalis of Meynert. ...
more infohttps://jhu.pure.elsevier.com/en/publications/regional-heterogeneity-of-choline-acetyltransferase-activity-in-p-4

In Vivo Positron Emission Tomography of Extrastriatal Non-Dopaminergic Pathology in Parkinson Disease | SpringerLinkIn Vivo Positron Emission Tomography of Extrastriatal Non-Dopaminergic Pathology in Parkinson Disease | SpringerLink

Tagliavini F, Pilleri G, Bouras C, Constantinidis J (1984) The basal nucleus of Meynert in idiopathic Parkinsons disease. Acta ... Candy JM, Perry RH, Perry EK, Irving D, Blessed G, Fairbairn AF et al (1983) Pathological changes in the nucleus of Meynert in ... Rogers JD, Brogan D, Mirra SS (1985) The nucleus basalis of Meynert in neurological disease: a quantitative morphological study ... Liu AK, Chang RC, Pearce RK, Gentleman SM (2015) Nucleus basalis of Meynert revisited: anatomy, history and differential ...
more infohttps://link.springer.com/chapter/10.1007%2F978-3-319-78926-2_7

Frontiers | Effects of acetylcholine on neuronal properties in entorhinal cortex | Frontiers in Behavioral NeuroscienceFrontiers | Effects of acetylcholine on neuronal properties in entorhinal cortex | Frontiers in Behavioral Neuroscience

... diencephalic and cortical relationships of the basal nucleus of meynert and associated structures in primates. J. Comp. Neurol. ... whereas the neocortex receives its forebrain cholinergic input from the nucleus basalis of Meynert (Jones et al., 1976; Mesulan ... Vertes, R. P., Fortin, W. J., Crane, A. M., Systems, C., and Raton, B. (1999). Projections of the median raphe nucleus. J. Comp ... It is likely that the modulatory functions of CCK expressing cells are mirrored in the EC as the median raphe nucleus sends ...
more infohttps://www.frontiersin.org/articles/10.3389/fnbeh.2012.00032/full

Switch to Europe/Worldwide websiteSwitch to Europe/Worldwide website

Anti-GABRA3 antibody IHC of human brain, basal nucleus of Meynert. Immunohistochemistry of formalin-fixed, paraffin-embedded ...
more infohttps://www.acris-antibodies.com/target/gabra3-antibody.htm?ab_host=Goat

Switch to Europe/Worldwide websiteSwitch to Europe/Worldwide website

Anti-GABRA3 antibody IHC of human brain, basal nucleus of Meynert. Immunohistochemistry of formalin-fixed, paraffin-embedded ...
more infohttps://www.acris-antibodies.com/target/gabra3-antibody.htm?donor_vector=mBFP-Neo

Neural Grafting to Experimental Neocortical Infarcts Improves Behavioral Outcome and Reduces Thalamic Atrophy in Rats Housed in...Neural Grafting to Experimental Neocortical Infarcts Improves Behavioral Outcome and Reduces Thalamic Atrophy in Rats Housed in...

b, Labeled cells in the host basal nucleus of Meynert. c, Labeled cells in the posterior thalamic nucleus. d, Labeled cells in ... Retrogradely labeled host neurons were also seen in the adjacent host cortex and in the host basal nucleus of Meynert, ... ventrobasal thalamic nucleus, and dorsal raphe nucleus (Fig 3⇓). In the same animals, anterograde tracing with biotinylated ... The lesion-induced atrophy in posterior thalamus with its major sensorimotor cortex relay nuclei was significantly reduced in ...
more infohttp://stroke.ahajournals.org/content/28/6/1225

Spatial Localization of A2E in the Retinal Pigment Epithelium | IOVS | ARVO JournalsSpatial Localization of A2E in the Retinal Pigment Epithelium | IOVS | ARVO Journals

Ulfig N . Altered lipofuscin pigmentation in the basal nucleus (Meynert) in Parkinsons disease. Neurosci Res. 1989;6:456-462. ...
more infohttp://iovs.arvojournals.org/article.aspx?articleid=2187017

Procedural memory - WikipediaProcedural memory - Wikipedia

Marginal division of the neostriatum that links the limbic system to the basal nucleus of Meynert". Journal of Neuroscience ... Striatum and basal gangliaEdit. Further information on the Striatum: Striatum. Further information on the Basal Ganglia: Basal ... 1999). "MRI study of basal ganglia volumes in drug-naive first-episode patients with schizophrenia". Schizophr Res. 36: 202.. ... Parent, A (1990). "Extrinsic connections of the basal ganglia". Trends Neurosci. 13: 254-258. doi:10.1016/0166-2236(90)90105-j. ...
more infohttps://en.m.wikipedia.org/wiki/Procedural_memories

Kanemaru K[au] - PubMed - NCBIKanemaru K[au] - PubMed - NCBI

Tau and TDP-43 accumulation of the basal nucleus of Meynert in individuals with cerebral lobar infarcts or hemorrhage. ... Reduction of Small Fibers of Thoracic Ventral Roots and Neurons of Intermediolateral Nucleus in Parkinson Disease and Dementia ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Kanemaru+K%5Bau%5D&dispmax=50

Acetylcholine Neurotransmission in CNS<...Acetylcholine Neurotransmission in CNS<...

These projections arise predominantly within the nucleus basalis of Meynert, also known as the Ch4 cell group. The cholinergic ... N2 - The hippocampus and cerebral neocortex receive massive cholinergic projections from the basal forebrain. These projections ... These projections arise predominantly within the nucleus basalis of Meynert, also known as the Ch4 cell group. The cholinergic ... These projections arise predominantly within the nucleus basalis of Meynert, also known as the Ch4 cell group. The cholinergic ...
more infohttps://www.scholars.northwestern.edu/en/publications/acetylcholine-neurotransmission-in-cns

Acetylcholine - WikipediaAcetylcholine - Wikipedia

In the basal forebrain, it originates from the basal nucleus of Meynert and medial septal nucleus:. *The ... An example of a central cholinergic area is the nucleus basalis of Meynert in the basal forebrain.[16][17] ... Basal nucleus of Meynert acts mainly on M1 receptors in the neocortex. ... lateral reticular nucleus and inferior olive.[9] It also projects to the thalamus, tectum, basal ganglia and basal forebrain.[8 ...
more infohttps://en.m.wikipedia.org/wiki/Acetylcholine

Neurotransmitters - Neurology - Medbullets Step 1Neurotransmitters - Neurology - Medbullets Step 1

Basal nucleus of Meynert. *Parkinsons disease. *Alzheimers disease. *Huntingtons disease. *Involved in learning and memory ...
more infohttps://step1.medbullets.com/neurology/113002/neurotransmitters

K. Soós - Research Output
     - Hungarian ConsortiumK. Soós - Research Output - Hungarian Consortium

β-amyloid(Phe(SO3H)24)25-35 in rat nucleus basalis induces behavioral dysfunctions, impairs learning and memory and disrupts ... Cholinotoxic effects of β-amyloid(1-42) peptide on cortical projections of the rat nucleus basalis magnocellularis. Harkany, T ... β-Amyloid neurotoxicity is mediated by a glutamate-triggered excitotoxic cascade in rat nucleus basalis. Harkany, T., Ábrahám, ...
more infohttps://hungary.pure.elsevier.com/hu/persons/k-so%C3%B3s/publications/?type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontojournal%2Farticle
  • The intracerebral course of the recurrent artery of Heubner is uni-vectorial, thereby heading towards the head of the caudate nucleus. (statpearls.com)
  • Among the histologic features found in AD, Alzheimer's neurofibrillary tangles (NFTs) are present in great profusion in the cerebral cortex with relative sparing of the occipital lobe and paracentral gyri, and are present in the basal nucleus of Meynert (bnM), hypothalamus, and tegmental nuclei of the rostral brain stem. (springer.com)
  • The arcuate nucleus produces inhibiting and releasing factors (adrenocorticotrophic hormone, beta-lipotrophic hormone, and beta-endorphin) for pituitary hormones. (thefreedictionary.com)
  • The lesion-induced atrophy in posterior thalamus with its major sensorimotor cortex relay nuclei was significantly reduced in grafted enriched rats compared with nongrafted enriched rats. (ahajournals.org)