Angioplasty, Balloon: Use of a balloon catheter for dilation of an occluded artery. It is used in treatment of arterial occlusive diseases, including renal artery stenosis and arterial occlusions in the leg. For the specific technique of BALLOON DILATION in coronary arteries, ANGIOPLASTY, BALLOON, CORONARY is available.Angioplasty, Balloon, Coronary: Dilation of an occluded coronary artery (or arteries) by means of a balloon catheter to restore myocardial blood supply.Neointima: The new and thickened layer of scar tissue that forms on a PROSTHESIS, or as a result of vessel injury especially following ANGIOPLASTY or stent placement.Angioplasty: Reconstruction or repair of a blood vessel, which includes the widening of a pathological narrowing of an artery or vein by the removal of atheromatous plaque material and/or the endothelial lining as well, or by dilatation (BALLOON ANGIOPLASTY) to compress an ATHEROMA. Except for ENDARTERECTOMY, usually these procedures are performed via catheterization as minimally invasive ENDOVASCULAR PROCEDURES.Stents: Devices that provide support for tubular structures that are being anastomosed or for body cavities during skin grafting.Angioplasty, Laser: A technique utilizing a laser coupled to a catheter which is used in the dilatation of occluded blood vessels. This includes laser thermal angioplasty where the laser energy heats up a metal tip, and direct laser angioplasty where the laser energy directly ablates the occlusion. One form of the latter approach uses an EXCIMER LASER which creates microscopically precise cuts without thermal injury. When laser angioplasty is performed in combination with balloon angioplasty it is called laser-assisted balloon angioplasty (ANGIOPLASTY, BALLOON, LASER-ASSISTED).Tunica Intima: The innermost layer of an artery or vein, made up of one layer of endothelial cells and supported by an internal elastic lamina.Catheterization: Use or insertion of a tubular device into a duct, blood vessel, hollow organ, or body cavity for injecting or withdrawing fluids for diagnostic or therapeutic purposes. It differs from INTUBATION in that the tube here is used to restore or maintain patency in obstructions.Recurrence: The return of a sign, symptom, or disease after a remission.Constriction, Pathologic: The condition of an anatomical structure's being constricted beyond normal dimensions.Angioplasty, Balloon, Laser-Assisted: Techniques using laser energy in combination with a balloon catheter to perform angioplasty. These procedures can take several forms including: 1, laser fiber delivering the energy while the inflated balloon centers the fiber and occludes the blood flow; 2, balloon angioplasty immediately following laser angioplasty; or 3, laser energy transmitted through angioplasty balloons that contain an internal fiber.Aortic Coarctation: A birth defect characterized by the narrowing of the AORTA that can be of varying degree and at any point from the transverse arch to the iliac bifurcation. Aortic coarctation causes arterial HYPERTENSION before the point of narrowing and arterial HYPOTENSION beyond the narrowed portion.Iliac Artery: Either of two large arteries originating from the abdominal aorta; they supply blood to the pelvis, abdominal wall and legs.Atherectomy, Coronary: Percutaneous transluminal procedure for removing atheromatous plaque from the coronary arteries. Both directional (for removing focal atheromas) and rotational (for removing concentric atheromatous plaque) atherectomy devices have been used.Coronary Angiography: Radiography of the vascular system of the heart muscle after injection of a contrast medium.Carotid Artery Injuries: Damages to the CAROTID ARTERIES caused either by blunt force or penetrating trauma, such as CRANIOCEREBRAL TRAUMA; THORACIC INJURIES; and NECK INJURIES. Damaged carotid arteries can lead to CAROTID ARTERY THROMBOSIS; CAROTID-CAVERNOUS SINUS FISTULA; pseudoaneurysm formation; and INTERNAL CAROTID ARTERY DISSECTION. (From Am J Forensic Med Pathol 1997, 18:251; J Trauma 1994, 37:473)Coronary Disease: An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.Femoral Artery: The main artery of the thigh, a continuation of the external iliac artery.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Coronary Vessels: The veins and arteries of the HEART.Graft Occlusion, Vascular: Obstruction of flow in biological or prosthetic vascular grafts.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Beta Particles: High energy POSITRONS or ELECTRONS ejected from a disintegrating atomic nucleus.Hyperplasia: An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.Arterial Occlusive Diseases: Pathological processes which result in the partial or complete obstruction of ARTERIES. They are characterized by greatly reduced or absence of blood flow through these vessels. They are also known as arterial insufficiency.Vascular Patency: The degree to which BLOOD VESSELS are not blocked or obstructed.Coronary Restenosis: Recurrent narrowing or constriction of a coronary artery following surgical procedures performed to alleviate a prior obstruction.Atherectomy: Endovascular procedure in which atheromatous plaque is excised by a cutting or rotating catheter. It differs from balloon and laser angioplasty procedures which enlarge vessels by dilation but frequently do not remove much plaque. If the plaque is removed by surgical excision under general anesthesia rather than by an endovascular procedure through a catheter, it is called ENDARTERECTOMY.Angiography: Radiography of blood vessels after injection of a contrast medium.Carotid Arteries: Either of the two principal arteries on both sides of the neck that supply blood to the head and neck; each divides into two branches, the internal carotid artery and the external carotid artery.Balloon Occlusion: Use of a balloon CATHETER to block the flow of blood through an artery or vein.Muscle, Smooth, Vascular: The nonstriated involuntary muscle tissue of blood vessels.Ultrasonography, Interventional: The use of ultrasound to guide minimally invasive surgical procedures such as needle ASPIRATION BIOPSY; DRAINAGE; etc. Its widest application is intravascular ultrasound imaging but it is useful also in urology and intra-abdominal conditions.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Popliteal Artery: The continuation of the femoral artery coursing through the popliteal fossa; it divides into the anterior and posterior tibial arteries.Retreatment: The therapy of the same disease in a patient, with the same agent or procedure repeated after initial treatment, or with an additional or alternate measure or follow-up. It does not include therapy which requires more than one administration of a therapeutic agent or regimen. Retreatment is often used with reference to a different modality when the original one was inadequate, harmful, or unsuccessful.Intra-Aortic Balloon Pumping: Counterpulsation in which a pumping unit synchronized with the patient's electrocardiogram rapidly fills a balloon in the aorta with helium or carbon dioxide in early diastole and evacuates the balloon at the onset of systole. As the balloon inflates, it raises aortic diastolic pressure, and as it deflates, it lowers aortic systolic pressure. The result is a decrease in left ventricular work and increased myocardial and peripheral perfusion.Myocardial Infarction: NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).Arteriosclerosis: Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.Angioscopy: Endoscopic examination, therapy or surgery performed on the interior of blood vessels.Gastric Balloon: An inflatable device implanted in the stomach as an adjunct to therapy of morbid obesity. Specific types include the silicone Garren-Edwards Gastric Bubble (GEGB), approved by the FDA in 1985, and the Ballobes Balloon.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Alloys: A mixture of metallic elements or compounds with other metallic or metalloid elements in varying proportions.Coronary Artery Bypass: Surgical therapy of ischemic coronary artery disease achieved by grafting a section of saphenous vein, internal mammary artery, or other substitute between the aorta and the obstructed coronary artery distal to the obstructive lesion.Rabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.Brachytherapy: A collective term for interstitial, intracavity, and surface radiotherapy. It uses small sealed or partly-sealed sources that may be placed on or near the body surface or within a natural body cavity or implanted directly into the tissues.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Angina Pectoris: The symptom of paroxysmal pain consequent to MYOCARDIAL ISCHEMIA usually of distinctive character, location and radiation. It is thought to be provoked by a transient stressful situation during which the oxygen requirements of the MYOCARDIUM exceed that supplied by the CORONARY CIRCULATION.Carotid Stenosis: Narrowing or stricture of any part of the CAROTID ARTERIES, most often due to atherosclerotic plaque formation. Ulcerations may form in atherosclerotic plaques and induce THROMBUS formation. Platelet or cholesterol emboli may arise from stenotic carotid lesions and induce a TRANSIENT ISCHEMIC ATTACK; CEREBROVASCULAR ACCIDENT; or temporary blindness (AMAUROSIS FUGAX). (From Adams et al., Principles of Neurology, 6th ed, pp 822-3)Saphenous Vein: The vein which drains the foot and leg.Thrombosis: Formation and development of a thrombus or blood clot in the blood vessel.Pulmonary Valve Stenosis: The pathologic narrowing of the orifice of the PULMONARY VALVE. This lesion restricts blood outflow from the RIGHT VENTRICLE to the PULMONARY ARTERY. When the trileaflet valve is fused into an imperforate membrane, the blockage is complete.Reoperation: A repeat operation for the same condition in the same patient due to disease progression or recurrence, or as followup to failed previous surgery.Swine: Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).Arteriovenous Shunt, Surgical: Surgical shunt allowing direct passage of blood from an artery to a vein. (From Dorland, 28th ed)Renal Artery Obstruction: Narrowing or occlusion of the RENAL ARTERY or arteries. It is due usually to ATHEROSCLEROSIS; FIBROMUSCULAR DYSPLASIA; THROMBOSIS; EMBOLISM, or external pressure. The reduced renal perfusion can lead to renovascular hypertension (HYPERTENSION, RENOVASCULAR).Blood Vessel Prosthesis: Device constructed of either synthetic or biological material that is used for the repair of injured or diseased blood vessels.Coronary Artery Disease: Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.Ischemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.Swine, Miniature: Genetically developed small pigs for use in biomedical research. There are several strains - Yucatan miniature, Sinclair miniature, and Minnesota miniature.Intermittent Claudication: A symptom complex characterized by pain and weakness in SKELETAL MUSCLE group associated with exercise, such as leg pain and weakness brought on by walking. Such muscle limpness disappears after a brief rest and is often relates to arterial STENOSIS; muscle ISCHEMIA; and accumulation of LACTATE.Fibromuscular Dysplasia: An idiopathic, segmental, nonatheromatous disease of the musculature of arterial walls, leading to STENOSIS of small and medium-sized arteries. There is true proliferation of SMOOTH MUSCLE CELLS and fibrous tissue. Fibromuscular dysplasia lesions are smooth stenosis and occur most often in the renal and carotid arteries. They may also occur in other peripheral arteries of the extremity.Carotid Artery, Common: The two principal arteries supplying the structures of the head and neck. They ascend in the neck, one on each side, and at the level of the upper border of the thyroid cartilage, each divides into two branches, the external (CAROTID ARTERY, EXTERNAL) and internal (CAROTID ARTERY, INTERNAL) carotid arteries.Blood Vessel Prosthesis Implantation: Surgical insertion of BLOOD VESSEL PROSTHESES to repair injured or diseased blood vessels.Platelet Aggregation Inhibitors: Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.Drug-Eluting Stents: Stents that are covered with materials that are embedded with chemicals that are gradually released into the surrounding milieu.Myocytes, Smooth Muscle: Non-striated, elongated, spindle-shaped cells found lining the digestive tract, uterus, and blood vessels. They are derived from specialized myoblasts (MYOBLASTS, SMOOTH MUSCLE).Thrombolytic Therapy: Use of infusions of FIBRINOLYTIC AGENTS to destroy or dissolve thrombi in blood vessels or bypass grafts.Ultrasonography, Doppler, Duplex: Ultrasonography applying the Doppler effect combined with real-time imaging. The real-time image is created by rapid movement of the ultrasound beam. A powerful advantage of this technique is the ability to estimate the velocity of flow from the Doppler shift frequency.Treatment Failure: A measure of the quality of health care by assessment of unsuccessful results of management and procedures used in combating disease, in individual cases or series.Cardiac Catheterization: Procedures in which placement of CARDIAC CATHETERS is performed for therapeutic or diagnostic procedures.Postoperative Complications: Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.Coronary Stenosis: Narrowing or constriction of a coronary artery.Polytetrafluoroethylene: Homopolymer of tetrafluoroethylene. Nonflammable, tough, inert plastic tubing or sheeting; used to line vessels, insulate, protect or lubricate apparatus; also as filter, coating for surgical implants or as prosthetic material. Synonyms: Fluoroflex; Fluoroplast; Ftoroplast; Halon; Polyfene; PTFE; Tetron.Coronary Thrombosis: Coagulation of blood in any of the CORONARY VESSELS. The presence of a blood clot (THROMBUS) often leads to MYOCARDIAL INFARCTION.Leg: The inferior part of the lower extremity between the KNEE and the ANKLE.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Limb Salvage: An alternative to amputation in patients with neoplasms, ischemia, fractures, and other limb-threatening conditions. Generally, sophisticated surgical procedures such as vascular surgery and reconstruction are used to salvage diseased limbs.Coronary Circulation: The circulation of blood through the CORONARY VESSELS of the HEART.Feasibility Studies: Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.Cell Division: The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.Pulmonary Veno-Occlusive Disease: Pathological process resulting in the fibrous obstruction of the small- and medium-sized PULMONARY VEINS and PULMONARY HYPERTENSION. Veno-occlusion can arise from fibrous proliferation of the VASCULAR INTIMA and VASCULAR MEDIA; THROMBOSIS; or a combination of both.Arteries: The vessels carrying blood away from the heart.Vascular Access Devices: Devices to be inserted into veins or arteries for the purpose of carrying fluids into or from a peripheral or central vascular location. They may include component parts such as catheters, ports, reservoirs, and valves. They may be left in place temporarily for therapeutic or diagnostic purposes.Iridium Radioisotopes: Unstable isotopes of iridium that decay or disintegrate emitting radiation. Ir atoms with atomic weights 182-190, 192, and 194-198 are radioactive iridium isotopes.Hypertension, Renovascular: Hypertension due to RENAL ARTERY OBSTRUCTION or compression.Balloon Valvuloplasty: Widening of a stenosed HEART VALVE by the insertion of a balloon CATHETER into the valve and inflation of the balloon.Peripheral Vascular Diseases: Pathological processes involving any one of the BLOOD VESSELS in the vasculature outside the HEART.Thrombectomy: Surgical removal of an obstructing clot or foreign material from a blood vessel at the point of its formation. Removal of a clot arising from a distant site is called EMBOLECTOMY.Endothelium, Vascular: Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.Prosthesis Design: The plan and delineation of prostheses in general or a specific prosthesis.Myocardial Revascularization: The restoration of blood supply to the myocardium. (From Dorland, 28th ed)Tunica Media: The middle layer of blood vessel walls, composed principally of thin, cylindrical, smooth muscle cells and elastic tissue. It accounts for the bulk of the wall of most arteries. The smooth muscle cells are arranged in circular layers around the vessel, and the thickness of the coat varies with the size of the vessel.Cardiovascular Agents: Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume.Coated Materials, Biocompatible: Biocompatible materials usually used in dental and bone implants that enhance biologic fixation, thereby increasing the bond strength between the coated material and bone, and minimize possible biological effects that may result from the implant itself.Aorta: The main trunk of the systemic arteries.Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Vascular System Injuries: Injuries to blood vessels caused by laceration, contusion, puncture, or crush and other types of injuries. Symptoms vary by site and mode of injuries and may include bleeding, bruising, swelling, pain, and numbness. It does not include injuries secondary to pathologic function or diseases such as ATHEROSCLEROSIS.Embolism: Blocking of a blood vessel by an embolus which can be a blood clot or other undissolved material in the blood stream.Budd-Chiari Syndrome: A condition in which the hepatic venous outflow is obstructed anywhere from the small HEPATIC VEINS to the junction of the INFERIOR VENA CAVA and the RIGHT ATRIUM. Usually the blockage is extrahepatic and caused by blood clots (THROMBUS) or fibrous webs. Parenchymal FIBROSIS is uncommon.Vascular Surgical Procedures: Operative procedures for the treatment of vascular disorders.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Amputation: The removal of a limb or other appendage or outgrowth of the body. (Dorland, 28th ed)Angina, Unstable: Precordial pain at rest, which may precede a MYOCARDIAL INFARCTION.Intracranial Arteriosclerosis: Vascular diseases characterized by thickening and hardening of the walls of ARTERIES inside the SKULL. There are three subtypes: (1) atherosclerosis with fatty deposits in the ARTERIAL INTIMA; (2) Monckeberg's sclerosis with calcium deposits in the media and (3) arteriolosclerosis involving the small caliber arteries. Clinical signs include HEADACHE; CONFUSION; transient blindness (AMAUROSIS FUGAX); speech impairment; and HEMIPARESIS.Combined Modality Therapy: The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.Subclavian Artery: Artery arising from the brachiocephalic trunk on the right side and from the arch of the aorta on the left side. It distributes to the neck, thoracic wall, spinal cord, brain, meninges, and upper limb.Lower Extremity: The region of the lower limb in animals, extending from the gluteal region to the FOOT, and including the BUTTOCKS; HIP; and LEG.Cell Movement: The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.Blood Flow Velocity: A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.Equipment Design: Methods of creating machines and devices.Aorta, Thoracic: The portion of the descending aorta proceeding from the arch of the aorta and extending to the DIAPHRAGM, eventually connecting to the ABDOMINAL AORTA.Models, Animal: Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.Life Tables: Summarizing techniques used to describe the pattern of mortality and survival in populations. These methods can be applied to the study not only of death, but also of any defined endpoint such as the onset of disease or the occurrence of disease complications.Fibrinolytic Agents: Fibrinolysin or agents that convert plasminogen to FIBRINOLYSIN.Electrocardiography: Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.Angiography, Digital Subtraction: A method of delineating blood vessels by subtracting a tissue background image from an image of tissue plus intravascular contrast material that attenuates the X-ray photons. The background image is determined from a digitized image taken a few moments before injection of the contrast material. The resulting angiogram is a high-contrast image of the vessel. This subtraction technique allows extraction of a high-intensity signal from the superimposed background information. The image is thus the result of the differential absorption of X-rays by different tissues.Immunoglobulin Fab Fragments: Univalent antigen-binding fragments composed of one entire IMMUNOGLOBULIN LIGHT CHAIN and the amino terminal end of one of the IMMUNOGLOBULIN HEAVY CHAINS from the hinge region, linked to each other by disulfide bonds. Fab contains the IMMUNOGLOBULIN VARIABLE REGIONS, which are part of the antigen-binding site, and the first IMMUNOGLOBULIN CONSTANT REGIONS. This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.Vascular Diseases: Pathological processes involving any of the BLOOD VESSELS in the cardiac or peripheral circulation. They include diseases of ARTERIES; VEINS; and rest of the vasculature system in the body.Veins: The vessels carrying blood away from the capillary beds.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Subclavian Steal Syndrome: A clinically significant reduction in blood supply to the BRAIN STEM and CEREBELLUM (i.e., VERTEBROBASILAR INSUFFICIENCY) resulting from reversal of blood flow through the VERTEBRAL ARTERY from occlusion or stenosis of the proximal subclavian or brachiocephalic artery. Common symptoms include VERTIGO; SYNCOPE; and INTERMITTENT CLAUDICATION of the involved upper extremity. Subclavian steal may also occur in asymptomatic individuals. (From J Cardiovasc Surg 1994;35(1):11-4; Acta Neurol Scand 1994;90(3):174-8)Peripheral Arterial Disease: Lack of perfusion in the EXTREMITIES resulting from atherosclerosis. It is characterized by INTERMITTENT CLAUDICATION, and an ANKLE BRACHIAL INDEX of 0.9 or less.Adenoviridae: A family of non-enveloped viruses infecting mammals (MASTADENOVIRUS) and birds (AVIADENOVIRUS) or both (ATADENOVIRUS). Infections may be asymptomatic or result in a variety of diseases.Renal Artery: A branch of the abdominal aorta which supplies the kidneys, adrenal glands and ureters.Chi-Square Distribution: A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.Endarterectomy, Carotid: The excision of the thickened, atheromatous tunica intima of a carotid artery.Sirolimus: A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.Phlebography: Radiographic visualization or recording of a vein after the injection of contrast medium.Aorta, Abdominal: The aorta from the DIAPHRAGM to the bifurcation into the right and left common iliac arteries.Carotid Artery, Internal: Branch of the common carotid artery which supplies the anterior part of the brain, the eye and its appendages, the forehead and nose.Collateral Circulation: Maintenance of blood flow to an organ despite obstruction of a principal vessel. Blood flow is maintained through small vessels.Risk Assessment: The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)Heparin: A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Its function is unknown, but it is used to prevent blood clotting in vivo and vitro, in the form of many different salts.Gene Transfer Techniques: The introduction of functional (usually cloned) GENES into cells. A variety of techniques and naturally occurring processes are used for the gene transfer such as cell hybridization, LIPOSOMES or microcell-mediated gene transfer, ELECTROPORATION, chromosome-mediated gene transfer, TRANSFECTION, and GENETIC TRANSDUCTION. Gene transfer may result in genetically transformed cells and individual organisms.Carotid Artery Diseases: Pathological conditions involving the CAROTID ARTERIES, including the common, internal, and external carotid arteries. ATHEROSCLEROSIS and TRAUMA are relatively frequent causes of carotid artery pathology.Vertebrobasilar Insufficiency: Localized or diffuse reduction in blood flow through the vertebrobasilar arterial system, which supplies the BRAIN STEM; CEREBELLUM; OCCIPITAL LOBE; medial TEMPORAL LOBE; and THALAMUS. Characteristic clinical features include SYNCOPE; lightheadedness; visual disturbances; and VERTIGO. BRAIN STEM INFARCTIONS or other BRAIN INFARCTION may be associated.Severity of Illness Index: Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.Survival Rate: The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.Platelet-Derived Growth Factor: Mitogenic peptide growth hormone carried in the alpha-granules of platelets. It is released when platelets adhere to traumatized tissues. Connective tissue cells near the traumatized region respond by initiating the process of replication.Survival Analysis: A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.Analysis of Variance: A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Wound Healing: Restoration of integrity to traumatized tissue.Anticoagulants: Agents that prevent clotting.Hypercholesterolemia: A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th percentile for the population.Prosthesis Implantation: Surgical insertion of a prosthesis.Postoperative Period: The period following a surgical operation.Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).Diet, Atherogenic: A diet that contributes to the development and acceleration of ATHEROGENESIS.Rhenium: Rhenium. A metal, atomic number 75, atomic weight 186.2, symbol Re. (Dorland, 28th ed)Cerebral Angiography: Radiography of the vascular system of the brain after injection of a contrast medium.Pressure: A type of stress exerted uniformly in all directions. Its measure is the force exerted per unit area. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Pulmonary Artery: The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs.Hemodynamics: The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.Dilatation: The act of dilating.Prosthesis Failure: Malfunction of implantation shunts, valves, etc., and prosthesis loosening, migration, and breaking.Disease-Free Survival: Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.Hospital Mortality: A vital statistic measuring or recording the rate of death from any cause in hospitalized populations.Radial Artery: The direct continuation of the brachial trunk, originating at the bifurcation of the brachial artery opposite the neck of the radius. Its branches may be divided into three groups corresponding to the three regions in which the vessel is situated, the forearm, wrist, and hand.Vena Cava, Inferior: The venous trunk which receives blood from the lower extremities and from the pelvic and abdominal organs.Laser Therapy: The use of photothermal effects of LASERS to coagulate, incise, vaporize, resect, dissect, or resurface tissue.Mitral Valve Stenosis: Narrowing of the passage through the MITRAL VALVE due to FIBROSIS, and CALCINOSIS in the leaflets and chordal areas. This elevates the left atrial pressure which, in turn, raises pulmonary venous and capillary pressure leading to bouts of DYSPNEA and TACHYCARDIA during physical exertion. RHEUMATIC FEVER is its primary cause.Paclitaxel: A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.Proliferating Cell Nuclear Antigen: Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types.Aortography: Radiographic visualization of the aorta and its branches by injection of contrast media, using percutaneous puncture or catheterization procedures.Multivariate Analysis: A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)Coronary Aneurysm: Abnormal balloon- or sac-like dilatation in the wall of CORONARY VESSELS. Most coronary aneurysms are due to CORONARY ATHEROSCLEROSIS, and the rest are due to inflammatory diseases, such as KAWASAKI DISEASE.Connective Tissue: Tissue that supports and binds other tissues. It consists of CONNECTIVE TISSUE CELLS embedded in a large amount of EXTRACELLULAR MATRIX.Injections, Intra-Arterial: Delivery of drugs into an artery.Iliac Vein: A vein on either side of the body which is formed by the union of the external and internal iliac veins and passes upward to join with its fellow of the opposite side to form the inferior vena cava.Cell Proliferation: All of the processes involved in increasing CELL NUMBER including CELL DIVISION.Jugular Veins: Veins in the neck which drain the brain, face, and neck into the brachiocephalic or subclavian veins.Predictive Value of Tests: In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.Blood Pressure: PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.Catheterization, Peripheral: Insertion of a catheter into a peripheral artery, vein, or airway for diagnostic or therapeutic purposes.Randomized Controlled Trials as Topic: Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.Myocardial Reperfusion: Generally, restoration of blood supply to heart tissue which is ischemic due to decrease in normal blood supply. The decrease may result from any source including atherosclerotic obstruction, narrowing of the artery, or surgical clamping. Reperfusion can be induced to treat ischemia. Methods include chemical dissolution of an occluding thrombus, administration of vasodilator drugs, angioplasty, catheterization, and artery bypass graft surgery. However, it is thought that reperfusion can itself further damage the ischemic tissue, causing MYOCARDIAL REPERFUSION INJURY.Kaplan-Meier Estimate: A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)Aneurysm, Dissecting: Aneurysm caused by a tear in the TUNICA INTIMA of a blood vessel leading to interstitial HEMORRHAGE, and splitting (dissecting) of the vessel wall, often involving the AORTA. Dissection between the intima and media causes luminal occlusion. Dissection at the media, or between the media and the outer adventitia causes aneurismal dilation.Patient Selection: Criteria and standards used for the determination of the appropriateness of the inclusion of patients with specific conditions in proposed treatment plans and the criteria used for the inclusion of subjects in various clinical trials and other research protocols.Ultrasonography, Doppler, Color: Ultrasonography applying the Doppler effect, with the superposition of flow information as colors on a gray scale in a real-time image. This type of ultrasonography is well-suited to identifying the location of high-velocity flow (such as in a stenosis) or of mapping the extent of flow in a certain region.Diabetic Angiopathies: VASCULAR DISEASES that are associated with DIABETES MELLITUS.Vascular Grafting: Surgical insertion of BLOOD VESSEL PROSTHESES, or transplanted BLOOD VESSELS, or other biological material to repair injured or diseased blood vessels.Hirudin Therapy: Use of HIRUDINS as an anticoagulant in the treatment of cardiological and hematological disorders.Metals: Electropositive chemical elements characterized by ductility, malleability, luster, and conductance of heat and electricity. They can replace the hydrogen of an acid and form bases with hydroxyl radicals. (Grant & Hackh's Chemical Dictionary, 5th ed)Safety: Freedom from exposure to danger and protection from the occurrence or risk of injury or loss. It suggests optimal precautions in the workplace, on the street, in the home, etc., and includes personal safety as well as the safety of property.Endovascular Procedures: Minimally invasive procedures, diagnostic or therapeutic, performed within the BLOOD VESSELS. They may be perfomed via ANGIOSCOPY; INTERVENTIONAL MAGNETIC RESONANCE IMAGING; INTERVENTIONAL RADIOGRAPHY; or INTERVENTIONAL ULTRASONOGRAPHY.Ultrasonography, Doppler: Ultrasonography applying the Doppler effect, with frequency-shifted ultrasound reflections produced by moving targets (usually red blood cells) in the bloodstream along the ultrasound axis in direct proportion to the velocity of movement of the targets, to determine both direction and velocity of blood flow. (Stedman, 25th ed)Registries: The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers.Regression Analysis: Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.Endarterectomy: Surgical excision, performed under general anesthesia, of the atheromatous tunica intima of an artery. When reconstruction of an artery is performed as an endovascular procedure through a catheter, it is called ATHERECTOMY.Vasodilator Agents: Drugs used to cause dilation of the blood vessels.Time: The dimension of the physical universe which, at a given place, orders the sequence of events. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Hemorrhage: Bleeding or escape of blood from a vessel.Drug Delivery Systems: Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.Evaluation Studies as Topic: Studies determining the effectiveness or value of processes, personnel, and equipment, or the material on conducting such studies. For drugs and devices, CLINICAL TRIALS AS TOPIC; DRUG EVALUATION; and DRUG EVALUATION, PRECLINICAL are available.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Ultrasonography: The visualization of deep structures of the body by recording the reflections or echoes of ultrasonic pulses directed into the tissues. Use of ultrasound for imaging or diagnostic purposes employs frequencies ranging from 1.6 to 10 megahertz.Partial Thromboplastin Time: The time required for the appearance of FIBRIN strands following the mixing of PLASMA with phospholipid platelet substitute (e.g., crude cephalins, soybean phosphatides). It is a test of the intrinsic pathway (factors VIII, IX, XI, and XII) and the common pathway (fibrinogen, prothrombin, factors V and X) of BLOOD COAGULATION. It is used as a screening test and to monitor HEPARIN therapy.
... in vascular smooth muscle cells of atherosclerotic lesions and in the neointima of restenosis after balloon angioplasty, both ... Suppression of CYR61 expression results in reduced neointimal hyperplasia after balloon angioplasty, an effect that is reversed ... "CCN1 Knockdown Suppresses Neointimal Hyperplasia in a Rat Artery Balloon Injury Model". Arterioscler. Thromb. Vasc. Biol. 28 (6 ...
... expression in arterial wall after balloon angioplasty correlates with late stages of neointima formation and ... Expression of T-cadherin is upregulated in atherosclerotic lesions and post-angioplasty restenosis -conditions associated with ... the exact role of T-cadherin in neointima formation and atherosclerosis development is poorly understood. LDL is not the only ...
The term neointima is used because the cells in the hyperplastic regions of the vascular wall have histological characteristics ... Mechanical injury of arterials due to stretching of arterial walls with a balloon catheter results in the recruitment of cells ... Angioplasty Drug-eluting stent Restenosis Stent Kleinedler, J.J. (2012). Novel nanocomposite stent coating releasing ... Systemic inflammation induced by lipopolysaccharide increases neointimal formation after balloon and stent injury in rabbits. ...
Angioplasty 101 Angioplasty.Org "Archived copy". Archived from the original on 2010-12-05. Retrieved 2010-09-28. Michel, Thomas ... the so-called neointima. Development of a neointima is variable but can at times be so severe as to re-occlude the vessel lumen ... The physician expands the balloon which deforms the metal stent to its expanded size. The cardiologist may "customize" the fit ... Intravascular Ultrasound - Angioplasty.Org Aoki J, Ong ATL, Granillo GAR, McFadden EP, van Mieghem CAG, Valgimigli M, Tsuchida ...
Most recent papers with the keyword Excimer laser coronary angioplasty | Read by QxMD
Treatment of in-stent restenosis with excimer laser coronary angioplasty: benefits over scoring balloon angioplasty alone. ... Therefore, we investigated the condition of the neointima after ELCA for ISR with optical coherence tomography (OCT) and ... treatment-of-in-stent-restenosis-with-excimer-laser-coronary-angioplasty-benefits-over-scoring-balloon-angioplasty-alone ... Such complex lesions are difficult to adequately treat with balloon angioplasty and/or intracoronary stenting. The aim of this ...
JCI - Balloon angioplasty enhances the expression of angiotensin II AT1 receptors in neointima of rat aorta.
Balloon angioplasty enhances the expression of angiotensin II AT1 receptors in neointima of rat aorta.. ... Balloon angioplasty enhances the expression of angiotensin II AT1 receptors in neointima of rat aorta.. ... in the neointima formed in the rat thoracic aorta 15 d after balloon-catheter injury. In contrast to the normal aortic wall, ... The apparent number of these receptors was fourfold higher in the neointima compared to that in the normal aortic wall. The ...
Kallikrein Gene Delivery Inhibits Vascular Smooth Muscle Cell Growth and Neointima Formation in the Rat Artery After Balloon...
A, normal rat carotid artery; B, rat carotid artery at 2 weeks after balloon angioplasty; C, balloon angioplasty plus delivery ... systemic balloon angioplasty. C indicates normal rats without operation; S, sham operation; A, balloon angioplasty. ... after balloon angioplasty. At 1 and 2 weeks after angioplasty by way of the common carotid artery, the relative level of rat ... lumen area in carotid artery 2 weeks after balloon angioplasty. Angioplasty, (n=8); Ad.CMV-LacZ (n=8); Ad.CMV-cHK (n=8); Ad.CMV ...
Short-term local delivery of an inhibitor of ras farnesyltransferase prevents neointima formation in vivo after porcine...
... of an inhibitor of ras farnesyltransferase prevents neointima formation in vivo after porcine coronary balloon angioplasty ... of an inhibitor of ras farnesyltransferase prevents neointima formation in vivo after porcine coronary balloon angioplasty. ... neointima, farnesyl transferase inhibitor, arteries, angioplasty, Pharmacy and materia medica, Cardiology and Cardiovascular ... Application of 25 µmol/L FPTIII locally for 15 minutes to balloon-injured porcine coronary arteries in vivo prevented neointima ...
Short-term local delivery of an inhibitor of ras farnesyltransferase prevents neointima formation in vivo after porcine...
... of an inhibitor of ras farnesyltransferase prevents neointima formation in vivo after porcine coronary balloon angioplasty ... of an inhibitor of ras farnesyltransferase prevents neointima formation in vivo after porcine coronary balloon angioplasty. ... Application of 25 μmol/L FPTIII locally for 15 minutes to balloon-injured porcine coronary arteries in vivo prevented neointima ... Background Mitogenic stimuli present at the site of coronary arterial balloon injury contribute to the progression and ...
CaMKII-δ Isoform Regulation of Neointima Formation After Vascular Injury | Arteriosclerosis, Thrombosis, and Vascular Biology
Balloon Angioplasty and Adenoviral Infection. Male Sprage-Dawley rats (350 g; Taconic Farms, Germantown, NY) were anesthetized ... Methods and Results- CaMKII isoform content was assessed in rat carotid arteries after balloon angioplasty-induced injury by ... CaMKIIδ2 Silencing Attenuates Neointima Formation. To assess the effects of siRNA-mediated CaMKIIδ2 suppression on neointima ... earlier reports indicated that migrating adventitial cells were first observed in the neointima 7 days after balloon injury.26 ...
Bergamot | GreenMedInfo | Substance | Natural Medicine | Alternative
B-Myb Represses Vascular Smooth Muscle Cell Collagen Gene Expression and Inhibits Neointima Formation After Arterial Injury |...
Extracellular matrix remodeling after balloon angioplasty injury in a rabbit model of restenosis. Circ Res. 1994; 75: 650-658. ... However, reoccurrence of arterial narrowing at the site of balloon angioplasty, termed restenosis, occurs in 30% to 50% of ... Atherosclerotic lesions are frequently treated by balloon angioplasty and stent placement. ... which occurs after balloon angioplasty or stenting of an atherosclerotic lesion; however, it may provide information on the SMC ...
Pathology of Second-Generation Everolimus-Eluting Stents Versus First-Generation Sirolimus- and Paclitaxel-Eluting Stents in...
... the neointima is focally dissected because of the balloon angioplasty with overlying nonocclusive thrombus. A high-power image ... The patient presented with acute myocardial infarction from stent thrombosis and underwent balloon angioplasty, which resulted ... A low-power histology image (c-2) shows a patent lumen with thin neointima. High-power images (c-3 to c-6) show focal mild ... High-power images (e to h) show focal inflammation within the neointima consisting of eosinophils (f) and T lymphocytes (g), ...
Effect of Selective or Combined Inhibition of Integrins αIIbβ3 and αvβ3 on Thrombosis and Neointima After Oversized Porcine...
1-sized inflation with a standard 20-mm coronary angioplasty balloon. Each artery was dilated twice for 30 seconds at 8 atm ... Background-Thrombosis and neointima formation limit the efficacy of coronary angioplasty (PTCA). Clinical trials have ... β3 on Thrombosis and Neointima After Oversized Porcine Coronary Angioplasty. Timothy J. A. Chico, Janet Chamberlain, Julian ... processes thought to be central to neointima formation,4 and antagonists of these mitogens reduce neointima formation.5 6 The ...
Effect of oral sirolimus therapy on inflammatory biomarkers following coronary stenting
Its inhibition reduces neointima formation in rats submitted to balloon angioplasty (32). In the present study, P-selectin ... Its efficacy in treating restenosis has been successfully tested in animal models of balloon angioplasty (17) and in humans ... Inhibition of intimal thickening after balloon angioplasty in porcine coronary arteries by targeting regulators of the cell ... which has been associated with decreased migration of smooth muscle cells to the intima after balloon angioplasty in animal ...
CYR61 - Wikipedia
... in vascular smooth muscle cells of atherosclerotic lesions and in the neointima of restenosis after balloon angioplasty, both ... Suppression of CYR61 expression results in reduced neointimal hyperplasia after balloon angioplasty, an effect that is reversed ... "CCN1 Knockdown Suppresses Neointimal Hyperplasia in a Rat Artery Balloon Injury Model". Arterioscler. Thromb. Vasc. Biol. 28 (6 ...
Internet Scientific Publications
The histopathology of neointima at this stage resembles that of restenotic lesions developing after balloon angioplasty. Beyond ... 8. de Feyter PJ, Van Suylen RJ, de Jaegere PP, et al : Balloon angioplasty for the treatment of lesions in saphenous vein ... In a randomized study (10), stenting for local SVBG lesions was shown to be superior to balloon angioplasty, with increased ... Kahn JK, Rutherford BD, McConahay DR et al : Initial and long-term outcome of 83 patients after balloon angioplasty of totally ...
Optical Frequency Domain Imaging of Covered Stent-Graft for Pulmonary Artery Pseudoaneurysm After Balloon Pulmonary Angioplasty...
The asterisks indicate neointima and the arrowhead indicates thrombus. ... 2015) Bail-out technique for pulmonary artery rupture with a covered stent in balloon pulmonary angioplasty for chronic ... Optical Frequency Domain Imaging of Covered Stent-Graft for Pulmonary Artery Pseudoaneurysm After Balloon Pulmonary Angioplasty ... Optical Frequency Domain Imaging of Covered Stent-Graft for Pulmonary Artery Pseudoaneurysm After Balloon Pulmonary Angioplasty ...
T-cadherin - Wikipedia
T-cadherin expression in arterial wall after balloon angioplasty correlates with late stages of neointima formation and ... Expression of T-cadherin is upregulated in atherosclerotic lesions and post-angioplasty restenosis -conditions associated with ... the exact role of T-cadherin in neointima formation and atherosclerosis development is poorly understood. LDL is not the only ...
Slow-Flow Phenomenon After Paclitaxel-Coated Balloon Angioplasty | JACC: Cardiovascular Interventions
... there are few reports on intracoronary imaging of the drug-coated neointima after PCB angioplasty. In the current report, slow- ... 13-mm conventional balloon catheter at 16 atm. After balloon angioplasty, Thrombolysis In Myocardial Infarction (TIMI) flow ... Slow-Flow Phenomenon After Paclitaxel-Coated Balloon Angioplasty. Hiroki Ikenaga, Satoshi Kurisu, Ken Ishibashi, Yoshihiro Dohi ... Slow-Flow Phenomenon After Paclitaxel-Coated Balloon Angioplasty. Hiroki Ikenaga, Satoshi Kurisu, Ken Ishibashi, Yoshihiro Dohi ...
Vascular response to intra-arterial injury in the thrombospondin-1 null mouse.
... denuded the endothelium and caused medial distension of the vessel in a manner similar to coronary artery balloon-angioplasty. ... These results provide in vivo evidence that the extent of smooth muscle cell proliferation and neointima formation following ... After 28 days, wildtype arteries showed consistent neointima formation with smooth muscle cell hyperplasia. Injured arteries ... from TSP-1 null mice showed similar neointimal lesions with no significant difference in the extent of neointima formation. ...
Blocking the MPO pathway might be a new therapeutic approach to restenosis after balloon angioplasty. .. ... The current proposal will identify a novel mediator, leukocyte-derived MPO, in neointima formation and its molecular mechanism( ... MPO and NO signaling in neointima formation. Chunxiang Zhang; Fiscal Year: 2010 ...
Current clinical applications of coronary optical coherence tomography | SpringerLink
... neointima were significantly higher in the plain old balloon angioplasty group than in the paclitaxel-coated balloon dilatation ... In addition, when various types of PCI, including plain old balloon angioplasty, paclitaxel-coated balloon dilatation, and drug ... a comparison between balloon angioplasty, paclitaxel-coated balloon dilatation, and drug-eluting stent implantation. Eur Heart ... stent group might be preferable for ISR lesions with homogeneous neointima compared with plain old balloon angioplasty. ...
US Patent # 9,974,672. Material structures for intravascular device - Patents.com
... has also been employed to reduce neointima formation by reducing smooth muscle cell proliferation after balloon angioplasty. ... One example of an intravascular device is a stent for use in, for instance, coronary angioplasty. Stents are small mechanical ... In addition, pharmacotherapeutic agents have been used for the treatment of some of the major post-angioplasty complications, ... a post-angioplasty stented site. Furthermore, the pores 141 may provide a space through which surrounding tissue may extend to ...
Repeated occurrence of slow flow phenomenon during and late after sirolimus-eluting stent implantation | SpringerLink
Importantly, there occurred slow flow again after balloon angioplasty for this lesion. We would suggest careful OCT examination ... Supplementary material 1 (MPEG 1548 kb) Movie 1. Pre-intervention optical coherence tomography movie shows fibrotic neointima ... and TCFA containing neointima surrounded by signal-poor, lipid-rich area in the proximal sirolimus-eluting stent ... a thin-cap fibroatheroma containing neointima surrounded by signal-poor, lipid-rich area in the proximal SES, suggesting the ...
Mitofusin 2 Triggers Vascular Smooth Muscle Cell Apoptosis via Mitochondrial Death Pathway | Circulation Research
... of rMfn-2 in balloon-injured rat carotid arteries increases VSMC apoptosis and attenuates angioplasty-induced neointima ... of an inhibitor of Ras farnesyltransferase prevents neointima formation in vivo after porcine coronary balloon angioplasty. ... At day 21 after balloon angioplasty, rat arteries from different experimental groups were harvested for histological analysis. ... Balloon Injury and Morphometric Analysis of Intimal Thickening. Balloon denudation and morphometric analysis of intimal ...
Time courses of apoptosis and cell proliferation and their relationship to arterial remodeling and restenosis after angioplasty...
After a bolus of 100 UI/kg heparin, angioplasty consisted of three inflations at 6 atm for 60 s, with an angioplasty balloon ... After angioplasty, cell proliferation was predominantly detected in the neointima, but it also occurred in the media and ... The apoptosis density was low in control arteries and dilated arteries 2 h after angioplasty, at the levels of the neointima, ... Rabbit femoral artery 14 days after balloon angioplasty. (A)Macrophages (brown)revealed by monoclonal anti-rabbit macrophage ( ...
p53 Expression Induces Apoptosis in Hippocampal Pyramidal Neuron Cultures | Journal of Neuroscience
Articles that mention Soo-Joong Kim -Optical Coherence Tomography News
Neointima characteristics as a prognostic marker for drug-coated balloon angioplasty in patients with in-stent restenosis: an ... angioplasty can differ in relation to in-stent neointimal characteristics. However, changes in neointima characteristics after ... Background Research has shown that the prognosis of in-stent restenosis (ISR) lesions after drug-coated balloon (DCB) ... This study sought to investigate changes in neointima characteristics after DCB for ISR. Methods From the Yonsei Optical ...
Connexins and Diabetes
C. E. Chadjichristos, C. M. Matter, I. Roth et al., "Reduced connexin43 expression limits neointima formation after balloon ... Recent study of connexins following balloon angioplasty has shown that this process is accompanied by elevated expression of ... Cx43 in endothelial cells and SMC of the media and later the neointima [32, 33]. Neointima formation following balloon catheter ... balloon injury and their combination," Journal of Vascular Research, vol. 34, no. 1, pp. 19-30, 1997. View at: Google Scholar*H ...
JCI - Smooth muscle cell-specific fibronectin-EDA mediates phenotypic switching and neointimal hyperplasia
PCI with balloon angioplasty, often followed by stent implantation, is the most commonly performed procedure for the reopening ... In mice, Fn-EDA colocalizes with SMCs in the neointima of injured carotid arteries and promotes neointima formation in the ... which include the use of a wire injury model that was chosen because it partially mimics balloon angioplasty or intraluminal ... Our studies are in agreement with previous studies that have shown an abundance of Fn-EDA in the neointima of human and rat ...
Adenovirus-mediated over-expression of the cyclin/cyclin-dependent kinase inhibitor, p21 inhibits vascular smooth muscle cell...
In addition, we demonstrate that localized arterial infection with a p21-encoding adenovirus at the time of balloon angioplasty ... including atherosclerosis and restenosis after balloon angioplasty. Thus, a better understanding of the molecular mechanisms ... vascular smooth muscle cell proliferation and neointima formation in the rat carotid artery model of balloon angioplasty.. @ ... vascular smooth muscle cell proliferation and neointima formation in the rat carotid artery model of balloon angioplasty.}, ...
BMP promotes motility and represses growth of smooth muscle cells by activation of tandem Wnt pathways | JCB
Increased in-stent stenosis in ApoE knockout mice: insights from a novel mouse model of balloon angioplasty and stenting. ... 9 B) of vessel sections revealed that the neointima area was more than twofold increased in ΔDEP Dvl-treated vessels compared ... B) Intimal response to balloon angioplasty and stenting comparing WT Dvl or ΔDEP Dvl. Representative images of histological ... 13-mm balloon angioplasty catheter (Ivatec International) and guided retrograde to the midportion of the descending thoracic ...
TNO Repository search for: subject:'Inhibitors'
Angiography · Angioplasty, Balloon · Animals · Arteriosclerosis · Iliac Artery · Immunohistochemistry · Macrophages · ... and neointima formation after balloon dilation. Methods and Results - In atherosclerotic iliac arteries of 12 Yucatan micropigs ... Background - Arterial remodeling after balloon angioplasty has been recognized as a major determinant of restenosis. ... Background - Inhibition of matrix metalloproteinase (MMP) activity after balloon angioplasty by intraperitoneal injection of ...
Application # 2017/0340432. Bioerodible Wraps and Uses Therefor - Patents.com
... balloon angioplasty. In addition, AVGs that undergo this hyperplastic remodeling exhibit decreased compliance as compared to ... 2002; 36: 150-7; and George S J, Zaltsman A B, and Newby A C. Surgical preparative injury and neointima formation increase MMP- ... intimal proliferation and apoptosis following balloon angioplasty in an atherosclerotic rabbit model. Cardiovasc Res. 2000; 45( ... Balloon inflation injury to the media was shown to promote ECM synthesis by SMCs as well as to decrease alpha actin content. ...
CoronaryPatientsArterialStent placementArteriesLesionsImplantationAtherosclerosis and restenosisOptical coherenceDrug-ElutinEnlargement remodeling after balloonProliferation and neointima formationStentsStenosisAtheroscleroticInhibitionCatheterFormation of neointimaVSMCsInterventionsConclusionsPaclitaxel-coated balloonPercutaneous Coronary IntVascular smoothIntravascularEndothelial injuryLipid-richPorcine modelInhibitUnderwentVivoCarotid artery balloon injuryCell proliferationEndotheliumInjury-induced restenosisGenesSignificantly decreased
- Excimer Laser Coronary Angioplasty with contrast medium injection is one possibility, but not readily available. (readbyqxmd.com)
- This study evaluated the clinical safety and 6-month efficacy of excimer laser coronary angioplasty (ELCA) before scoring balloon dilatation for the treatment of ISR. (readbyqxmd.com)
- Background- Mitogenic stimuli present at the site of coronary arterial balloon injury contribute to the progression and development of a restenotic lesion, many signaling through a common pathway involving the small G protein p21ras. (strath.ac.uk)
- However, reoccurrence of arterial narrowing at the site of balloon angioplasty, termed restenosis, occurs in 30% to 50% of patients. (ahajournals.org)
- Neointima development is characteristic of experimental and therapeutic arterial injury 1 and is an important component of restenosis after percutaneous transluminal coronary angioplasty (PTCA). (ahajournals.org)
- 11 12 α v β 3 expression is upregulated after arterial injury 13 and thus may play a role in neointima formation. (ahajournals.org)
- Animal studies of platelet inhibition or depletion on neointimal responses to arterial injury have shown conflicting results, whereas most studies with selective α v β 3 antagonists or peptides with wider integrin specificity have shown reductions in neointima development. (ahajournals.org)
- T-cadherin expression in arterial wall after balloon angioplasty correlates with late stages of neointima formation and coincidentally with the peak in proliferation and differentiation of vascular cells. (wikipedia.org)
- Background The mechanisms controlling arterial remodeling after angioplasty remain poorly understood. (onlinejacc.org)
- Apoptosis, cell proliferation, residual stenosis and arterial remodeling were evaluated at 2 h and 3, 7, 14, 21 and 28 days after angioplasty. (onlinejacc.org)
- Apoptosis density was positively correlated with arterial remodeling in the neointima and media (r = 0.69, p = 0.005 and r = 0.50, p = 0.05, respectively). (onlinejacc.org)
- Although apoptosis and cell proliferation have been extensively studied after balloon angioplasty, the relationships between apoptosis, cell proliferation, arterial remodeling and restenosis have not been evaluated (8-15) . (onlinejacc.org)
- Vascular smooth muscle cell (VSMC) proliferation after arterial injury is important in the pathogenesis of a number of vascular proliferative disorders, including atherosclerosis and restenosis after balloon angioplasty. (semanticscholar.org)
- Drug-eluting balloons can help treat arterial ischemic disease. (escardio.org)
- iNOS is induced throughout the arterial media within VSMC soon after balloon injury and persists for up to 21 days. (ox.ac.uk)
- In the second experiment, arterial neointima hyperplasia reached delsummit at 28 days in the angioplasty group and 14 days in the BA with angioplasty group. (bmj.com)
- Some issues relate to the performance of PCI and these include the development of bare metal stents (BMS), which have surpassed balloon angioplasty in the management of coronary artery disease because one of their ability to prevent restenosis by suppressing arterial recoil and contraction. (acls.com)
- OBJECTIVE: To assess the effectiveness of lovastatin, an HMGCoA reductase inhibitor, in the inhibition of coronary arterial restenosis post-balloon angioplasty. (elsevier.com)
- The balloons were intentionally overexpanded to create arterial injury. (elsevier.com)
- We have shown previously that increased uPA expression greatly promotes neointima formation and inward arterial remodeling after balloon injury. (researchwithnj.com)
- Background: To determine the transcriptional, biochemical, and histomorphometric correlates of neointimal procollagen accumulation during arterial repair after balloon angioplasty of atherogenic vessels, rabbit iliac artery collagen content and the induction of α 1 (I) and α 1 (III) procollagen mRNA were assessed in normal vessels and at 2, 7, and 30 days after angioplasty. (elsevier.com)
- Arterial cross-sectional area reduction, total cellularity, and vascular smooth muscle cell density (per 10 4 μ 2 of neointima) were quantified in routine and immunohistochemically stained sections (α-actin and RAM-11), from which biochemical concentrations of tissue protein, RNA, and DNA were also measured. (elsevier.com)
- Since the pioneering work by Dotter and Judkins 1 more than 3 decades ago, percutaneous transluminal angioplasty (PTA) is still considered the gold standard for endovascular treatment of patients with symptomatic femoropop-liteal arterial occlusive disease (FPAOD). (appliedradiology.com)
- Atherosclerotic lesions are frequently treated by balloon angioplasty and stent placement. (ahajournals.org)
- The authors reviewed their experience to determine whether a staged procedure consisting of angioplasty followed by delayed (≥ 1 month later) repeated angioplasty and stent placement reduces the morbidity associated with endovascular treatment of symptomatic basilar and/or intracranial vertebral artery (VA) stenoses. (thejns.org)
- Among the patients in whom staged stent-assisted angioplasty was planned, vessel dissection, which necessitated immediate stent placement, occurred during passage of the balloon in one of them. (thejns.org)
- In a second patient, the stent could not be maneuvered through the tortuous VA. In a third patient, the VA and BAs remained widely patent after angioplasty alone, and therefore stent placement was not required. (thejns.org)
- The novel combination of initial angioplasty followed by delayed endoluminal stent placement may reduce the neurological morbidity associated with endovascular treatment of long, high-grade stenotic lesions. (thejns.org)
- The treatment of choice for the management of ST-elevation myocardial infarction is coronary angioplasty with or without stent placement. (acls.com)
- The arguments for balloon angioplasty or stent placement in FPAOD include the low risk of the procedure and the preserved potential for bypass surgery. (appliedradiology.com)
- The new and thickened layer of scar tissue that forms on a PROSTHESIS, or as a result of vessel injury especially following ANGIOPLASTY or stent placement. (bioportfolio.com)
- Occurrence of stenosis frequently requires treatment-usually making use of balloon angioplasty and, in the central venous system, also resulting in stent placement as ultima ratio. (vascularnews.com)
- FPTIII also prevented p42/p44 MAPK activation and DNA synthesis in response to platelet-derived growth factor in these cells at a concentration of 25 µmol/L. Application of 25 µmol/L FPTIII locally for 15 minutes to balloon-injured porcine coronary arteries in vivo prevented neointima formation assessed at 4 weeks, reduced proteoglycan deposition, and inhibited adventitial hypertrophy. (strath.ac.uk)
- FPTIII also prevented p42/p44 MAPK activation and DNA synthesis in response to platelet-derived growth factor in these cells at a concentration of 25 μmol/L. Application of 25 μmol/L FPTIII locally for 15 minutes to balloon-injured porcine coronary arteries in vivo prevented neointima formation assessed at 4 weeks, reduced proteoglycan deposition, and inhibited adventitial hypertrophy. (gla.ac.uk)
- Methods and Results- CaMKII isoform content was assessed in rat carotid arteries after balloon angioplasty-induced injury by Western blotting with isoform specific antibodies. (ahajournals.org)
- A dramatic reduction in neointima formation and lumenal narrowing was observed in arteries of B- myb transgenic versus WT mice 4 weeks after injury. (ahajournals.org)
- Injured arteries from TSP-1 null mice showed similar neointimal lesions with no significant difference in the extent of neointima formation. (biomedsearch.com)
- Second, overexpression of Mfn-2 also triggers apoptosis of VSMCs in culture and in balloon-injured rat carotid arteries, thus contributing to Mfn-2-mediated prevention of neointima formation after angioplasty. (ahajournals.org)
- One month later, angioplasty was performed in 40 arteries. (onlinejacc.org)
- In mice, Fn-EDA colocalizes with SMCs in the neointima of injured carotid arteries and promotes neointima formation in the comorbid condition of hyperlipidemia by potentiating SMC proliferation and migration. (jci.org)
- Expression of VDR and TNF-α and the effect of vitamin D deficiency in post-angioplasty coronary arteries were analyzed by immunohistochemistry and histomorphometry. (nih.gov)
- Rat carotid arteries that were subjected to balloon injury and transduced with Ad-15-LOX1 upon exposure to [ 3 H]arachidonic acid ex vivo produced 15-HETE as a major eicosanoid and enhanced balloon injury-induced expression of MCP-1 in smooth muscle cells in Src and STAT-3-dependent manner in vivo. (elsevier.com)
- In addition, transduction of Ad-15-LOX1 into arteries enhanced balloon injury-induced smooth muscle cell migration from media to intima and neointima formation. (elsevier.com)
- One way to restore physiological blood flow to occluded arteries involves the deformation of plaque using an intravascular balloon and preventing elastic recoil using a stent. (tcd.ie)
- We use either local adenoviral-mediated overexpression of tPA or systemic infusion of recombinant tPA combined with mechanical overdilation of rabbit common femoral arteries to evaluate the impact of tPA on neointima formation. (elsevier.com)
- Methods: Left common femoral arteries of New Zealand white rabbits were transfected in situ either with an adenoviral-construct-expressing tPA or a viral control (adenoviral-construct-expressing β-galactosidase) or nonviral (buffer) control after balloon angioplasty injury. (elsevier.com)
- One or more coronary arteries were injured by deployment of tantalum wire stents delivered on oversized percutaneous transluminal coronary angioplasty balloons. (elsevier.com)
- Increased expression of IL-18 and IL-18R/ß mRNA was detectable in carotid arteries from days 2 to 14 after angioplasty. (strath.ac.uk)
- Narrowed coronary arteries were originally treated percutaneously with balloon angioplasty alone [ 4 ]. (mdpi.com)
- Immunohistochemistry experiments showed abundant Cdc42 in the neointima of treated arteries. (elsevier.com)
- The distribution and size of ischemic lesions after carotid artery angioplasty and stenting: evidence for microembolization to terminal arteries. (springermedizin.de)
- The histopathology of neointima at this stage resembles that of restenotic lesions developing after balloon angioplasty. (ispub.com)
- Expression of T-cadherin is upregulated in atherosclerotic lesions and post-angioplasty restenosis -conditions associated with pathological angiogenesis. (wikipedia.org)
- Background Research has shown that the prognosis of in-stent restenosis (ISR) lesions after drug-coated balloon (DCB) angioplasty can differ in relation to in-stent neointimal characteristics. (octnews.org)
- Decreased expression of vitamin D receptors in neointimal lesions following coronary artery angioplasty in atherosclerotic swine. (nih.gov)
- Here, we investigated the expression of TNF-α and VDR in post-angioplasty coronary artery neointimal lesions of hypercholesterolemic swine and examined the effect of vitamin D deficiency on the development of coronary restenosis. (nih.gov)
- OCT-based neointima was categorized as homogeneous (n = 227 lesions in 208 patients), heterogeneous (n = 79 lesions in 73 patients), or layered (n = 62 lesions in 55 patients). (onlinejacc.org)
- Stent implantation has grown so much that it now comprises 60-70% of all percutaneous coronary revascularisation interventions, and assuming a conservative 25% restenosis rate for a total of around one million percutaneous transluminal coronary angioplasty (PTCA) procedures this year, more than 150 000 lesions will need treatment because of in-stent restenosis. (bmj.com)
- 23 So, at least for lesions with inadequate initial expansion of the stent and for very focal neointimal growths, balloon dilatation can be an effective solution, both immediately and in the long term. (bmj.com)
- We hypothesized that the differential enhancement of glucose metabolism in the neointima contributed to formation of lesions by increasing the resistance of VSMCs to apoptosis. (diabetesjournals.org)
- In case 2, a 80-year-old man with BMS-ISR 17 years after BMS implantation in the proximal left anterior descending coronary artery underwent a PCB angioplasty. (onlinejacc.org)
- The capabilities of OCT are well suited for the identification of calcified plaque and neointima formation after stent implantation. (springer.com)
- balloon angioplasty') and coronary stent implantation. (portlandpress.com)
- Previous treatment of the target lesion included balloon angioplasty and drug-eluting stent (DES) implantation. (vasculardiseasemanagement.com)
- Following vascular injury, e.g., after coronary stent implantation, neointima formation occurs because of the accumulation of smooth muscle cells (SMCs), which may lead to restenosis ( 71 ). (physiology.org)
- Since the balloon is immediately deflated after maximal inflation during stent implantation and 80% of the expandable wire mesh of the stent was open surface opposing elastic recoil, the process minimized endothelial damage compared to balloon angioplasty alone [ 5 ]. (mdpi.com)
Atherosclerosis and restenosis2
- 1 This process contributes to the pathogenesis of several cardiovascular disorders, including atherosclerosis and restenosis after angioplasty. (ahajournals.org)
- Together, these data indicated that magnesium lithospermate B, a potent reactive oxygen species scavenger, prevented both injury-induced neointimal formation in vivo and PDGF-BB-induced VSMC proliferation and migration in vitro, suggesting that magnesium lithospermate B may be a promising agent to prevent atherosclerosis and restenosis following angioplasty. (unboundmedicine.com)
- Frequency-domain optical coherence tomography (FD-OCT) revealed homogeneous neointima ( Figure 1B-a ) and coronary angioscopy (CAS) revealed white neointimal coverage at the ISR site ( Figure 1C-a ). (onlinejacc.org)
- (B) Frequency-domain optical coherence tomography (FD-OCT) findings at baseline (a) and post PCB angioplasty (b) . (onlinejacc.org)
- Pre-procedural optical coherence tomography (OCT) imaging revealed multiple intimal ruptures, cavity formation behind the stent struts, a thin-cap fibroatheroma containing neointima surrounded by signal-poor, lipid-rich area in the proximal SES, suggesting the progression of neoatherosclerosis within SES. (springer.com)
- Interfering with the Dvl-dependent Wnt-PCP activation in a murine stented aortic graft injury model promotes extensive neointima formation, as shown by optical coherence tomography and histopathology. (rupress.org)
- Drug-eluting balloons - rather then conventional balloon angioplasty, reflecting that coronary procedures are usually stent-based with established antiproliferative therapy - were compared to drug eluting stents. (escardio.org)
- To overcome the neointima scar tissue, drug-eluting stents (DES) were introduced in the United States with Cypher (Cordis) in 2003 and Taxus (Boston Scientific) in 2004. (dicardiology.com)
- The introduction of polymer-coated drug-eluting stents (DES), which allow for localised delivery of anti-proliferative drugs such as sirolimus and paclitaxel to the neointima, was a key advance that resulted in dramatically reduced BKM120 ISR rates of significantly less than 10% in preliminary clinical studies. (cancer-colorectal.com)
- Drug-eluting balloons and drug-eluting stents have been successfully implemented in the treatment of coronary artery disease. (vascularnews.com)
Enlargement remodeling after balloon1
Proliferation and neointima formation2
- These results provide in vivo evidence that the extent of smooth muscle cell proliferation and neointima formation following endothelial denuding injury is not affected by the absence of TSP-1. (biomedsearch.com)
- Adenovirus-mediated over-expression of the cyclin/cyclin-dependent kinase inhibitor, p21 inhibits vascular smooth muscle cell proliferation and neointima formation in the rat carotid artery model of balloon angioplasty. (semanticscholar.org)
- This provided the rationale for coating stents with substances such as sirolimus and paclitaxel, which inhibit the growth and proliferation of smooth muscle cells, the major cellular constituent of the neointima. (asahq.org)
- SVG blockages can be opened by using small balloons and stents (metal coils that keep the artery open). (clinicaltrials.gov)
- Bare metal stents (BMS) were introduced in 1994 as an improvement over balloon angioplasty alone, which had a high restenosis rate of between 30-40 percent. (dicardiology.com)
- The first balloon expandable stents were designed from surgical grade stainless steel, and aimed to provide additional mechanical support, limiting vessel recoil and preventing acute occlusion [ 6 ]. (mdpi.com)
- Stents were initially evaluated in a preclinical study relative to angioplasty alone, in canine coronaries to assess efficacy prior to human trials [ 5 , 7 ]. (mdpi.com)
- Early bare metal stents (BMS) were developed to limit post-angioplasty restenosis, although their success was limited by significant rates (15-30%) of in-stent restenosis (ISR) . (cancer-colorectal.com)
- Bioabsorbable polymer everolimus-eluting stents in patients with acute myocardial infarction: a report from the Swedish Coronary Angiography and Angioplasty Registry. (bioportfolio.com)
- Moreover, residual stenosis was inversely correlated with apoptosis density in the neointima and media (r = −0.62, p = 0.008 and r = −0.52, p = 0.04, respectively). (onlinejacc.org)
- Percutaneous transluminal coronary angioplasty is the predominant treatment for coronary vessel stenosis. (google.ca)
- Accumulating evidence suggests that urokinase plasminogen activator (uPA) is involved in vascular remodeling and lumen stenosis after angioplasty and stenting. (researchwithnj.com)
- This results in the designated proliferation of VSMCs to form the neointima, which leads to stenosis of the vascular lumen. (ece-inhibitor.com)
- In recurrent stenosis, high pressure balloons or cutting balloons are often used, while stenting (including stent grafts) should be initially avoided for as long as possible, although some authors have also documented good results using stent grafts and higher patency rates using cutting balloons. (vascularnews.com)
- The authors retrospectively reviewed the medical records in a consecutive series of eight patients who underwent planned stent-assisted angioplasty for medically refractory, symptomatic atherosclerotic disease of the intracranial posterior circulation between February 1999 and January 2002. (thejns.org)
- 5 Specific Ang II receptor antagonists can also partially inhibit neointima formation, which suggests that the inhibition of neointima formation by ACE inhibitors is, in part, because of a decreased level of Ang II. (ahajournals.org)
- The increase in local kinin accumulation may also be involved in the inhibition of neointima formation because icatibant, a bradykinin B 2 receptor antagonist, can partially block the protective effect of ACE inhibitors. (ahajournals.org)
- Two weeks after transfection, antisense oligo treatment directed against either CDC2 kinase or cyclin B1 resulted in a partial, but significant, inhibition in neointima formation. (duke.edu)
- Interestingly, co-transfection of antisense oligos against CDC2 kinase and cyclin B resulted in further inhibition of neointima formation, as compared to blockade of either gene target alone. (duke.edu)
- and (ii) HVJ-mediated administration of antisense CDC2 kinase and cyclin B1 oligos produces a sustained inhibition of neointima formation after balloon angioplasty. (duke.edu)
- We have examined, using quantitative autoradiography, the expression of angiotensin II receptor subtypes AT1 and AT2, and angiotensin-converting enzyme, in the neointima formed in the rat thoracic aorta 15 d after balloon-catheter injury. (jci.org)
- However, the time-domain OCT system needed an over-the-wire-type catheter with an occlusion balloon to obtain continuous long-sectional images due to the limitation of pullback speed. (springer.com)
- The balloon catheter injury was performed on left common carotid artery of rat by imitating the process of angioplasty. (bmj.com)
- Methods and Results - Endothelial denudation of the left carotid artery was performed by use of a balloon embolectomy catheter. (strath.ac.uk)
- We used a standard model of the balloon catheter injury of the rat carotid followed by periadventitial application to the injured vessel of either uPA dissolved in Pluronic gel, or plain gel. (researchwithnj.com)
Formation of neointima1
- To explore potential roles of the kallikrein-kinin system in vascular biology, we evaluated the effects of adenovirus-mediated human kallikrein gene delivery on the growth of primary cultured VSMCs and in balloon-injured rat artery in vivo. (ahajournals.org)
- This study was to explore the effects of Gan-Lu-Yin (GLY) on the migration of vascular smooth muscle cells (VSMCs) induced by fetal bovine serum and on neointima formation in a rat model of carotid artery balloon injury. (biomedcentral.com)
- Conclusion - Balloon angioplasty leads to the phosphorylation of FKHRL1 and decreased expression of p27, thereby promoting a proliferative phenotype in VSMCs in vitro and in vivo. (elsevier.com)
- It is well known that coronary artery angioplasty and stenting are both associated with local vascular and systemic inflammation (1-4), which in turn correlate with increased restenosis after percutaneous coronary interventions (PCI) (5-7). (scielo.br)
- Conclusions- The study demonstrates in the pig that short-term local delivery of inhibitors of p21ras-dependent mitogenic signal transduction prevents restenosis after balloon angioplasty. (strath.ac.uk)
- Conclusions The study demonstrates in the pig that short-term local delivery of inhibitors of p21 ras -dependent mitogenic signal transduction prevents restenosis after balloon angioplasty. (gla.ac.uk)
- Conclusions: There were no differences in 9-month luminal dimensions of the side branch between the Tryton Stent and Side Branch Balloon Angioplasty, as assessed with IVUS (MLA) and 3D QCA (MLD). (eur.nl)
- CONCLUSIONS: Although lovastatin produced a statistically significant decrease in neointimal thickness post-balloon angioplasty, when extrapolated to angiographical end-points, the differences would not be clinically significant. (elsevier.com)
- Conclusions: We conclude that procollagen genes are transcriptionally activated early (2 to 7 days) after angioplasty vessel injury and that collagen subsequently constitutes a major biochemical and histological component of the proliferative neointima by 30 days after angioplasty. (elsevier.com)
- (A) Coronary angiography at baseline (a) , at paclitaxel-coated balloon (PCB) angioplasty (b) , and at the end of procedure (c) . (onlinejacc.org)
- Coronary angioscopy after paclitaxel-coated balloon angioplasty revealed that undissolved drugs were floating and flowed distally ( C-c, blue arrow , Online Video 1 ). (onlinejacc.org)
- Angiographic and clinical performance of a paclitaxel coated balloon compared to a 2nd generation sirolimus eluting stent in patients with in-stent restenosis- the BIOLUX randomized controlled trial. (bioportfolio.com)
Percutaneous Coronary Int1
- Overexpression of rat Mfn-2 (rMfn-2) overtly suppresses the mitogenic stimulus-evoked vascular smooth muscle cell (VSMC) proliferation in culture and blocks balloon injury-induced restenosis in vivo via inhibiting the Ras-Raf-MEK-ERK/MAPK signaling pathway, independent of its functional role in mitochondrial fusion. (ahajournals.org)
- Objective: Randomized comparison between the Tryton Side Branch Stent (Tryton Medical, Durham, NC), used in combination with a main branch drug-eluting stent (DES), and side branch balloon angioplasty (SBBA, in combination with a main branch DES) using intravascular ultrasound (IVUS), and three-dimensional quantitative coronary angiography (3D-QCA). (eur.nl)
- 1 Hence, 1 of the aims of the present study was to test the hypothesis that 2-ME can inhibit vascular injury-induced neointima formation. (ahajournals.org)
- 18 In the present studies we used the in vivo balloon-injured rat carotid artery model and demonstrated similar CaMKII isoform modulation in medial wall VSM and adventitial fibroblasts within 3 days after injury. (ahajournals.org)
- In vivo, the phosphorylation of FKHRL1 increased significantly 3 hours after balloon injury and decreased thereafter, with the subsequent downregulation of p27. (elsevier.com)
Carotid artery balloon injury1
- The injury completely denuded the endothelium and caused medial distension of the vessel in a manner similar to coronary artery balloon-angioplasty. (biomedsearch.com)
- METHODS: Pigs were sacrificed at various time points to follow NOS expression in the neointima, media and regenerated endothelium. (ox.ac.uk)
- A restenosis model was established by balloon rubbing the endothelium of the abdominal aorta followed by high fat diet. (springer.com)