Clindamycin plus gentamicin as expectant therapy for presumed mixed infections. (1/368)The prevalence of obligate anaerobes was studied prospectively in 60 patients with severe sepsis of intra-abdominal, soft tissue, female genital or oropulmonary origin. In addition, the efficacy of clindamycin (for anaerobes) plus gentamicin (for aerobic bacteria, especially coliforms) as initial empiric therapy in these patients was evaluated. Among 54 patients with cultural proof of infection, anaerobic pathogens were recovered from 52%. Nineteen patients had bacteremia; Bacteroides fragilis and Klebsiella pneumoniae were the most prevalent pathogens, being isolated in five patients each. Infection was eradicated in 56 of the 60 patients (93%). Mortality related to sepsis was 7% in the entire group, 16% in patients with bacteremia and 2% in patients without bacteremia. Eighty-five percent of aerobic isolates tested were susceptible in vitro to either gentamicin or clindamycin; 97% of anaerobic isolates were inhibited by 5 mug/ml of clindamycin. (+info)
The in-vitro activity of linezolid (U-100766) and tentative breakpoints. (2/368)The in-vitro activity of linezolid, a novel oxazolidinone, was investigated in comparison with those of amoxycillin, cefuroxime, quinupristin/dalfopristin, trovafloxacin and vancomycin against 420 recent Gram-positive and anaerobic clinical isolates. Linezolid was equally active (MIC90 1 mg/L) against methicillin-susceptible and -resistant Staphylococcus aureus. It demonstrated uniform activity against streptococci and enterococci and no cross-resistance with other agents. The time-kill kinetic data demonstrated that the in-vitro activity of linezolid was predominantly bacteriostatic; slow bactericidal activity was only observed at the higher concentration with streptococci. An increase in inoculum from 10(4) to 10(6) cfu on selected strains had little effect on the MICs (MIC90 within one dilution step) of linezolid and an increase in inoculum from 10(5) to 10(7) cfu/mL had no notable effect on the in-vitro bactericidal activity. A tentative linezolid breakpoint of 2 mg/L was chosen after analysis of distribution of susceptibilities. (+info)
TNF-binding protein ameliorates inhibition of skeletal muscle protein synthesis during sepsis. (3/368)We examined the effects of TNF-binding protein (TNFBP) on regulatory mechanisms of muscle protein synthesis during sepsis in four groups of rats: Control; Control+TNFBP; Septic; and Septic+TNFBP. Saline (1. 0 ml) or TNFBP (1 mg/kg, 1.0 ml) was injected daily starting 4 h before the induction of sepsis. The effect of TNFBP on gastrocnemius weight, protein content, and the rate of protein synthesis was examined 5 days later. Sepsis reduced the rate of protein synthesis by 35% relative to controls by depressing translational efficiency. Decreases in protein synthesis were accompanied by similar reductions in protein content and muscle weight. Treatment of septic animals with TNFBP for 5 days prevented the sepsis-induced inhibition of protein synthesis and restored translational efficiency to control values. TNFBP treatment of Control rats for 5 days was without effect on muscle protein content or protein synthesis. We also assessed potential mechanisms regulating translational efficiency. The phosphorylation state of p70(S6) kinase was not altered by sepsis. Sepsis reduced the gastrocnemius content of eukaryotic initiation factor 2Bepsilon (eIF2Bepsilon), but not eIF2alpha. The decrease in eIF2Bepsilon content was prevented by treatment of septic rats with TNFBP. TNFBP ameliorates the sepsis-induced changes in protein metabolism in gastrocnemius, indicating a role for TNF in the septic process. The data suggest that TNF may impair muscle protein synthesis by reducing expression of specific initiation factors during sepsis. (+info)
Characterization of bacteroides melaninogenicus. (4/368)Fifty-eight human isolates of Bacteroides melaninogenicus, 42 from a variety of clinical infections and the rest from normal flora, were studied for pigment production and ultraviolet light fluorescence and by forty biochemical and other tests, including end-product analysis by gas-liquid chromatography. In a number of instances, tests were repeated several times and the results were reproducible. Agar plate dilution susceptibility tests were also performed to 12 antimicrobial agents. These 58 strains could be reliably placed into three groups, corresponding to the three subspecies described, based on seven characteristics. These included acid production in peptone-yeast-glucose medium, production of n-butyric acid from peptone-yeast-glucose medium, esculin hydrolysis, starch hydrolysis, indole production, effect on milk, and lipase production. Production of hydrogen gas in peptone-yeast-fructose medium may be another distinguishing characteristic. In general there was not much difference in the susceptibility of the three groups to the various antimicrobial agents tested. Two strains had a minimal inhibitory concentration of penicillin G of 16 and 32 U/ml, respectively. Three strains did not produce a black pigment in spite of prolonged incubation on blood-containing media. (+info)
Differential induction of colitis and gastritis in HLA-B27 transgenic rats selectively colonized with Bacteroides vulgatus or Escherichia coli. (5/368)Resident bacteria play an important role in initiating and perpetuating gastrointestinal inflammation. We previously demonstrated that six commensal bacteria including Bacteroides vulgatus caused more aggressive colitis and gastritis in HLA-B27 transgenic rats than did the other five bacteria without B. vulgatus. This study compared the degree of gastrointestinal inflammation in gnotobiotic HLA-B27 transgenic rats monoassociated with either B. vulgatus or Escherichia coli. Gnotobiotic transgenic rats raised in Trexler isolators were selectively colonized with either B. vulgatus or E. coli. Control rats were either germfree or colonized with six common commensal bacteria (Streptococcus faecium, E. coli, Streptococcus avium, Eubacterium contortum, Peptostreptococcus productus, and B. vulgatus [DESEP-B]). After 1 month, all the rats were killed and tissues were prepared for histologic and biochemical evaluation. Colitis induced by B. vulgatus monoassociation was almost equal to that in DESEP-B-colonized rats and was significantly more severe than E. coli-induced colitis, which was absent by histological testing and mild by colonic myeloperoxidase and interleukin-1beta concentration determinations. However, gastritis was detectable only in DESEP-B-associated rats. These studies suggest that not all resident bacteria have equal proinflammatory capabilities, since B. vulgatus alone is more active than E. coli alone in inducing colitis, and that colitis and gastritis result from different luminal bacterial stimuli. (+info)
Analysis of a capsular polysaccharide biosynthesis locus of Bacteroides fragilis. (6/368)A major clinical manifestation of infection with Bacteroides fragilis is the formation of intra-abdominal abscesses, which are induced by the capsular polysaccharides of this organism. Transposon mutagenesis was used to locate genes involved in the synthesis of capsular polysaccharides. A 24,454-bp region was sequenced and found to contain a 15,379-bp locus (designated wcf) with 16 open reading frames (ORFs) encoding products similar to those encoded by genes of other bacterial polysaccharide biosynthesis loci. Four genes encode products that are similar to enzymes involved in nucleotide sugar biosynthesis. Seven genes encode products that are similar to sugar transferases. Two gene products are similar to O-acetyltransferases, and two products are probably involved in polysaccharide transport and polymerization. The product of one ORF, WcfH, is similar to a set of deacetylases of the NodB family. Deletion mutants demonstrated that the wcf locus is necessary for the synthesis of polysaccharide B, one of the two capsular polysaccharides of B. fragilis 9343. The virulence of the polysaccharide B-deficient mutant was comparable to that of the wild type in terms of its ability to induce abscesses in a rat model of intra-abdominal infection. (+info)
In vivo protection of Fusobacterium necrophorum from penicillin by Bacteroides fragilis. (7/368)A mixed infection of Bacteroides fragilis and Fusobacterium necrophorum was resistant to treatment with penicillin even though a pure F. necrophorum infection could be successfully treated with penicillin. Since B. fragilis alone did not produce infection, these results indicate that B. fragilis can protect F. necrophorum from penicillin in vivo. The extent of protection afforded by a strain of B. fragilis was related to its level of resistance to penicillin. Only a few cells of B. fragilis were required in the initial bacterial injection. Moreover, protection was demonstrated when B. fragilis cells were injected as late as 24 h after the F. necrophorum cells. Protection of F. necrophorum from penicillin by B. fragilis was also demonstrated in vitro. (+info)
Identification of a third metalloprotease toxin gene in extraintestinal isolates of Bacteroides fragilis. (8/368)To further understand the epidemiology of enterotoxigenic Bacteroides fragilis (ETBF), 89 extraintestinal B. fragilis strains from Seoul, Korea, were examined for secretion of B. fragilis toxin (BFT) by the HT29/C1 biologic assay and for the B. fragilis toxin gene (bft) by colony blot hybridization and PCR. Complete agreement between the three techniques was found. Overall, 34 B. fragilis strains (38%) were identified as ETBF. Eleven of the 34 ETBF strains (32%) expressed a new isoform of BFT (Korea-BFT). This new isoform is more related to BFT-2 than to BFT-1. Like BFT-1 and BFT-2, Korea-BFT cleaves E-cadherin, the zonula adherens protein. (+info)
Bacteroides infections are a type of bacterial infection caused by the Bacteroides genus of bacteria. These bacteria are commonly found in the human gut and play an important role in the digestive process, but they can also cause infections in various parts of the body.
Types of Bacteroides Infections:
1. Bacteroides fragilis: This type of infection is caused by the Bacteroides fragilis bacterium and is typically found in the gut, skin, and respiratory tract.
2. Bacteroides vulgatus: This type of infection is caused by the Bacteroides vulgatus bacterium and is commonly found in the gut and respiratory tract.
3. Bacteroides caccae: This type of infection is caused by the Bacteroides caccae bacterium and is typically found in the gut and skin.
4. Bacteroides distasonis: This type of infection is caused by the Bacteroides distasonis bacterium and is commonly found in the gut and respiratory tract.
5. Bacteroides eggerthii: This type of infection is caused by the Bacteroides eggerthii bacterium and is typically found in the gut and skin.
Causes and Risk Factors:
Bacteroides infections can occur due to a variety of factors, including:
1. Weakened immune system: People with weakened immune systems, such as those with cancer, HIV/AIDS, or taking immunosuppressive drugs, are more susceptible to Bacteroides infections.
2. Injury or trauma: Injuries or traumas to the skin or gut can provide an entry point for Bacteroides bacteria to enter the body and cause an infection.
3. Surgery: People who have undergone surgery, particularly gastrointestinal surgery, are at risk of developing Bacteroides infections.
4. Contaminated medical devices: Medical devices such as catheters or implantable devices can become contaminated with Bacteroides bacteria and cause an infection.
5. Poor hygiene: Poor hygiene practices, such as not washing hands regularly or not sterilizing medical equipment, can increase the risk of developing a Bacteroides infection.
6. Smoking: Smoking can weaken the immune system and increase the risk of developing Bacteroides infections.
7. Diabetes: People with diabetes are more susceptible to developing Bacteroides infections, particularly in the skin and soft tissues.
8. Obesity: Obesity can increase the risk of developing Bacteroides infections, particularly in the gut and respiratory tract.
The symptoms of Bacteroides infections vary depending on the location of the infection and the severity of the infection. Some common symptoms of Bacteroides infections include:
1. Skin infections: Redness, swelling, warmth, and pain at the site of the infection. Pus-filled abscesses may also develop.
2. Respiratory infections: Coughing, difficulty breathing, chest pain, and fever.
3. Gastrointestinal infections: Diarrhea, abdominal pain, nausea, and vomiting.
4. Bone and joint infections: Pain, swelling, and limited mobility in the affected limb.
5. Urinary tract infections: Painful urination, frequency of urination, and cloudy or strong-smelling urine.
6. Sepsis: Fever, chills, rapid heart rate, and confusion or disorientation.
Bacteroides infections can be difficult to diagnose because the bacteria can be found on the skin and in the gut of healthy individuals. However, there are several tests that can help healthcare providers diagnose a Bacteroides infection:
1. Blood cultures: Blood cultures can be used to detect the presence of Bacteroides bacteria in the bloodstream.
2. Urine cultures: Urine cultures can be used to detect the presence of Bacteroides bacteria in the urinary tract.
3. Surgical wound cultures: Surgical wound cultures can be used to detect the presence of Bacteroides bacteria in wounds.
4. Imaging studies: Imaging studies such as X-rays, CT scans, and MRI scans can help healthcare providers visualize the location and extent of the infection.
5. PCR (polymerase chain reaction) testing: PCR testing can be used to detect the presence of Bacteroides DNA in a sample of blood or tissue.
The treatment of Bacteroides infections depends on the severity and location of the infection, as well as the individual's overall health. Some common treatments for Bacteroides infections include:
1. Antibiotics: Bacteroides bacteria are typically resistant to antibiotics, but some strains may be susceptible to certain types of antibiotics such as cefoxitin, imipenem-cilastatin, and meropenem.
2. Surgical drainage: If the infection is localized and does not respond to antibiotic therapy, surgical drainage may be necessary to remove the infected tissue or fluid.
3. Supportive care: Patients with severe Bacteroides infections may require hospitalization and supportive care such as intravenous fluids, oxygen therapy, and monitoring of vital signs.
4. Probiotics: Probiotics are beneficial bacteria that can help restore the balance of gut flora and may be used to treat Bacteroides infections.
5. Enzyme-based therapy: Enzyme-based therapy, such as collagenase, can be used to break down the extracellular matrix that surrounds the bacteria and help eliminate them from the body.
Preventing Bacteroides infections is challenging, but there are some measures that can be taken to reduce the risk of infection. These include:
1. Proper wound care: Wounds should be cleaned and covered with sterile dressings to prevent bacterial growth.
2. Good hygiene: Hands should be washed frequently, especially after contact with wounds or contaminated surfaces.
3. Proper sterilization of medical equipment: All medical equipment should be properly sterilized before use to prevent the spread of infection.
4. Vaccination: Vaccines are available for some types of Bacteroides, such as the Bacteroides fragilis vaccine, which can help prevent infections caused by this bacterium.
5. Antibiotic stewardship: Antibiotics should be used judiciously and only when necessary to prevent the development of antibiotic-resistant bacteria.
Overall, Bacteroides infections can be challenging to diagnose and treat, but with appropriate management and prevention strategies, patients can recover fully. It is important to seek medical attention if symptoms persist or worsen over time, as early intervention can improve outcomes.
Abortion, Septic: A potentially life-threatening complication of an abortion procedure that occurs when bacteria enter the uterus and cause infection. Symptoms may include fever, chills, abdominal pain, nausea, vomiting, and vaginal discharge with a foul odor. Septic abortion can be caused by poor surgical technique, contamination of instruments, or failure to use sterile equipment. Treatment may involve antibiotics, surgical drainage of the infection, and supportive care. In severe cases, hospitalization and intensive care may be necessary to manage the infection and prevent complications such as sepsis or shock.
The term "septic abortion" is used to describe an abortion that has become infected, usually as a result of poor surgical technique or contamination during the procedure. This type of infection can be serious and potentially life-threatening, so it is important for women who have had an abortion to seek medical attention immediately if they experience any symptoms of infection.
Symptoms of septic abortion may include fever, chills, abdominal pain, nausea, vomiting, and vaginal discharge with a foul odor. In severe cases, women may develop sepsis or shock, which can be fatal if not treated promptly.
Treatment for septic abortion typically involves antibiotics to clear the infection, as well as surgical drainage of any abscesses that have formed in the uterus or other pelvic tissues. In some cases, hospitalization and intensive care may be necessary to manage the infection and prevent complications.
Preventing septic abortion is important, and this can be achieved by ensuring that proper surgical technique is used during the abortion procedure, using sterile equipment and supplies, and providing adequate aftercare to women who have had an abortion. Women who have had an abortion should seek medical attention immediately if they experience any symptoms of infection, as prompt treatment can help prevent serious complications and improve outcomes.
Impacted wisdom teeth
Microbial drug delivery
Altered Schaedler flora
List of MeSH codes (C01)
Peptidoglycan recognition protein 3
Putative holin-2 family
Innate immune system
Pelvic inflammatory disease
Bacteroides Infection: Background, Pathophysiology, Epidemiology
Bacteroides Infection: Background, Pathophysiology, Epidemiology
Pathogenicity of capsulate and non-capsulate members of Bacteroides fragilis and B. melaninogenicus groups in mixed infection...
A mixed infection involving Bacteroides denticanum, Lactobacillus salivarius, and Streptococcus anginosus as causative agents...
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- Synergistic effect of Bacteroides, Clostridium, Fusobacterium , anaerobic cocci, and aerobic bacteria on mortality and induction of subcutaneous abscesses in mice. (microbiologyresearch.org)
- Metronidazole is used to treat infections caused by Bacteroides species, Clostridium infections and Fusobacterium infections. (pipelinepharma.com)
- INVANZ is indicated for the treatment of adult patients and pediatric patients (3 months of age and older)with complicated intra-abdominal infections due to Escherichia coli, Clostridium clostridioforme, Eubacterium lentum, Peptostreptococcus species, Bacteroides fragilis, Bacteroides distasonis,Bacteroides ovatus. (bigsurspiritgarden.com)
- Spiramycin has a therapeutic spectrum including Gram-positive aerobes such as staphylococci, streptococci and Bacillus, but also including anaerobes such as Actinomyces, Clostridium and Bacteroides. (justlikechildren.store)
- She is an infectious diseases expert who has focused on gut infections including diarrhea, foodborne illnesses Clostridium difficile (C. diff) and Helicobacter pylori during her career. (nih.gov)
- Comparison of activities of penicillin G and new β -lactam antibiotics against clinical isolates of Bacteroides species. (microbiologyresearch.org)
- Enhancement of growth of aerobic and facultative bacteria in mixed infections with Bacteroides species. (microbiologyresearch.org)
- It is highly effective against all species of anaerobes except certain non-spore-forming gram-positive bacilli and cocci and is the only agent rapidly bactericidal against the Bacteroides fragilis group. (nih.gov)
- the most commonly isolated anaerobes are various species of Fusobacterium, Bacteroides, Porphyromonas, and Prevotella. (cdc.gov)
- The prevention of post-operative infections due to anaerobic bacteria (particularly species of bacteroides and anaerobic streptococci). (com.bd)
- Flegyl is active against a wide range of pathogenic micro-organisms notably species of Bacteroides , Fusobacteria , Clostridia , Eubacteria , anaerobic cocci and Gardnerella vaginalis . (pillintrip.com)
- 1. Treatment of infections in which anaerobic bacteria have been identified or are suspected as pathogens, particularly Bacteroides fragilis and other species of Bacteroides and including other species for which metronidazole is bactericidal, such as Fusobacteria , Eubacteria , Clostridia and anaerobic cocci. (pillintrip.com)
- Respiratory tract infections caused by Klebsiella species. (ndrugs.com)
- Propionibacterium acnes Gram-negative bacilli Bacteroides fragilis group are the most frequently recovered species of Bacteroidaceae. (symptoma.com)
- Propionibacterium species are colonizing the human skin and mouth and are frequently recovered from mixed infections of the skin and soft tissue, acne vulgaris and infections linked to operative procedures or foreign bodies (13, 48). (symptoma.com)
- Metronidazole has antimicrobial activity against most anaerobes, including Bacteroides, Fusobacterium and spirochaetes. (justlikechildren.store)
- [ 2 ] and predominate in intra-abdominal infections and infections that originate from those florae (eg, perirectal abscesses , decubitus ulcers ). (medscape.com)
- Intra-abdominal infections are those contained within the peritoneum or retroperitoneal space. (antiinfectivemeds.com)
- Secondary intra-abdominal infections are often polymicrobial. (antiinfectivemeds.com)
- The frequencies with which specific bacteria were isolated in intra-abdominal infections are given in Table Pathogens Isolated from Patients with Secondary Peritonitis . (antiinfectivemeds.com)
- In intra-abdominal infections, facultative bacteria may provide an environment conducive to the growth of anaerobic bacteria. (antiinfectivemeds.com)
- Although AGNB perform beneficial functions as part of the GI flora, they are also consummate opportunistic pathogens that can cause serious infections, typically in synergistic infections in combination with other anaerobic as well as aerobic bacteria. (medscape.com)
- Selective antimicrobial agents directed against either aerobic or anaerobic bacteria were used alone or in combination to explore the effect of eradication of one component of the mixed infection. (microbiologyresearch.org)
- Anaerobic bacteria in pediatric respiratory infections: progress in diagnosis and treatment. (microbiologyresearch.org)
- To reduce the development of drug-resistant bacteria and maintain the effectiveness of ampicillin and sulbactam for injection, USP and other antibacterial drugs, ampicillin and sulbactam for injection, USP should be used only to treat infections that are proven or strongly suspected to be caused by bacteria. (nih.gov)
- Infections with bacteria of the family BACTEROIDACEAE . (nih.gov)
- Infections with bacteria of the genus BACTEROIDES. (bvsalud.org)
- They also found bacteria "common to fecal matter and gut flora" at significantly higher levels downwind than upwind, including several that can cause human infections, including including corynebacterium , Leptospira, Clostridia, Bacteroides, and Staphylococcus. (motherjones.com)
- Co-infection is defined as the occurrence of infections by two or more infectious (pathogenic or non-pathogenic) agents - either concurrently or sequentially - and includes both acute and chronic infections by viruses, bacteria, parasites, and/or other microorganisms. (nih.gov)
- Any disruption of the seal between the proximal nail fold and the nail plate can cause acute infections of the eponychial space by providing a portal of entry for bacteria. (aafp.org)
- The prevalence and role of anaerobic bacteria in bone infection were investigated in this prospective study on 134 cases with pyogenic osteomyelitis. (who.int)
- Gut bacteria could influence whether or not babies survive infections of the digestive system, new research with mice suggests. (fabresearch.org)
- Hundreds of thousands of babies worldwide die every year from infections that ravage their digestive systems, including those caused by salmonella and E. coli bacteria. (fabresearch.org)
- The bacteria Clostridia provide animals key protection against infection, in addition to helping digest food. (fabresearch.org)
- With no natural gut bacteria of their own, the mice offered a unique chance to see the effects of transplanted microbes from normal mice of different ages and to test vulnerability to infection. (fabresearch.org)
- They found that the samples from the older normal mice had the most diversity of gut microbes, including Clostridia and Bacteroides bacteria not seen in the younger mice that were still getting their nutrition entirely from mother's milk. (fabresearch.org)
- Next, the researchers looked at what happened to germ-free mice that had been given a newborn mouse's microbes, but with extra doses of either Clostridia or Bacteroides bacteria added in. (fabresearch.org)
- Because E. coli and salmonella also affect adults, the researchers tested what happened when normal adult mice were given vancomycin, an antibiotic that selectively kills bacteria like Clostridia and Bacteroides . (fabresearch.org)
- Anaerobic bacteria can cause disease in the abdomen and pelvis, and metronidazole is used to treat these gastrointestinal infections as well as parasitic infections. (pipelinepharma.com)
- Flegyl is indicated in the prophylaxis and treatment of infections in which anaerobic bacteria have been identified or are suspected to be the cause. (pillintrip.com)
- Intra-abdominal infection results from entry of bacteria into the peritoneal or retroperitoneal spaces or from bacterial collections within intra-abdominal organs. (antiinfectivemeds.com)
- Aerobic enteric bacteria and anaerobic bacteria are both pathogens in intra-abdominal infection. (antiinfectivemeds.com)
- Peptostreptococcus infection is rarely reported in general practice, but this genus of anaerobic bacteria can cause infections of virtually any tissue. (symptoma.com)
- This photomicrograph of an unknown sample revealed the presence of a mixed infection, which included Gram-positive, Peptostreptococcus anaerobius , and P. asaccharolyticus , formerly Peptococcus asaccharolyticus , and anaerobic, Gram-negative, Prevotella melaninogenica , formerly Bacteroides melaninogenicus , bacteria. (cdc.gov)
- For the treatment of Anaerobic bacterial infections, the recommended loading dose for adults in 15 mg/kg infused over one hour with maintenance dose of 7.5 mg/kg infused over one hour for every six hours. (pipelinepharma.com)
- Ertapenem is a carbapenem antibiotic used for the treatment of moderate to severe bacterial infections caused by specific sensitive organisms. (bigsurspiritgarden.com)
- Invanz is a prescription medicine used to treat the symptoms of various bacterial infections in the skin, lungs, stomach, pelvis, and urinary tract. (bigsurspiritgarden.com)
- The gut microbiota is believed to play (a) key role(s) in maintaining and supporting human health, and any disturbance in its composition, sometimes referred to as intestinal dysbiosis, is believed to facilitate the onset of and/or aggravate certain diseases, including autoimmune and allergic diseases, colorectal cancer, metabolic diseases and bacterial infections. (biomedcentral.com)
- Flegyl has been used successfully in: septicaemia, bacteraemia, brain abscess, necrotising pneumonia, osteomyelitis, puerperal sepsis, pelvic abscess, pelvic cellulitis, peritonitis and post-operative wound infection from which one or more of these anaerobes have been isolated. (pillintrip.com)
- They exposed groups of these mice to C. rodentium and found that only the mice given Clostridia were able to resist the infections. (fabresearch.org)
- Raised in a germ-free environment and then given a transplant of gut microbes from a four-day-old normal mouse, these mice were still able to resist salmonella infection without any help from their immune system-but only when they had received a dose of added Clostridia first. (fabresearch.org)
- These data demonstrate the synergy between all members of the B. fragilis group and E. coli and between the B. melaninogenicus group and S. pyogenes , and reiterate the need to direct antimicrobial therapy at the eradication of the aerobic and anaerobic components of mixed infections. (microbiologyresearch.org)
- The relationships between capsulate and non-capsulate Bacteroides fragilis strains and Escherichia coli , and between capsulate and non-capsulate strains of the B. melaninogenicus group and Streptococcus pyogenes , were studied in a subcutaneous abscess model in mice. (microbiologyresearch.org)
- Pathogenicity of encapsulated Bacteroides melaninogenicus group, B. oralis and B rumincolasubsp. (microbiologyresearch.org)
- Pathogenicity of capsulate and non-capsulate members of Bacteroides fragilis and B. melaninogenicus groups in mixed infection with Escherichia coli and Streptococcus pyogenes. (microbiologyresearch.org)
- Single therapy of mixed infection directed at the elimination of only one organism ( S. pyogenes, E. coli or Bacteroides sp. (microbiologyresearch.org)
- Therapy directed at the elimination of S. pyogenes and E. coli did not prevent the emergence of capsulate Bacteroides spp. (microbiologyresearch.org)
- Matrix-assisted laser desorption/ionization- time -of-flight mass spectrometry ( MALDI -TOF MS) identified Bacteroides pyogenes, Lactobacillus salivarius , and Streptococcus anginosus from abscess aspiration. (bvsalud.org)
- [ 1 ] group and other anaerobic gram-negative bacilli (AGNB) that were previously included in the Bacteroides genus but are now included in the Prevotella and Porphyromonas genera. (medscape.com)
- Red complex" (Bacteroides forsythus, Porphyromonas gingivalis, and Treponema denticola) in endodontic infections: a molecular approach. (bvsalud.org)
- This incident highlighted the risk of exposure to exotic zoonotic pathogens and the need for infection control precautions in veterinary medicine. (cdc.gov)
- Rarely, bite and scratch wounds may result in serious systemic infections caused by invasive pathogens such as Capnocytophaga canimorsus, Bergeyella zoohelcum, CDC group NO-1, and Bartonella spp. (cdc.gov)
- Furthermore, they are among the most frequently described pathogens when it comes to polymicrobial infections , especially in the formation of abscesses . (symptoma.com)
- Prevotella bivia and Prevotella disiens (previously called Bacteroides ) are important in obstetric and gynecologic infections. (medscape.com)
- Abstract: In addition to infections, gut commensal microbes influence the pathogenesis of autoimmune diseases. (nih.gov)
- P. acnes can cause shunt infections, 6 and play a role in the pathogenesis of acne vulgaris . (symptoma.com)
- In the laboratory and in clinical settings, she has studied the pathogenesis of enterotoxigenic Bacteroides fragilis (ETBF) over the past 25 years. (nih.gov)
- Invanz (ertapenem for injection) is a type of antibiotic used to treat severe infections of the skin, lungs, stomach, pelvis, and urinary tract. (bigsurspiritgarden.com)
- A mixed infection involving Bacteroides denticanum, Lactobacillus salivarius, and Streptococcus anginosus as causative agents of abscess around a pharyngo-esophageal anastomosis and acute vertebral osteomyelitis: Identification by ribosomal RNA sequencing of bacterial isolates. (bvsalud.org)
- As we will describe in the coming sections, narrowing the type of necrotizing soft tissue infections to Group A β-hemolytic Streptococcus (GAS) or clostridial infection may be useful in better defining prognosis and in identifying patients that may benefit from additional treatment options. (antimicrobe.org)
- Upper respiratory infections caused by Streptococcus pneumoniae. (ndrugs.com)
- More recently, metronidazole has emerged as a principal agent for the treatment of anaerobic infections. (nih.gov)
- 11. The Intestinal Commensal, Bacteroides fragilis, Modulates Host Responses to Viral Infection and Therapy: Lessons for Exploration during Mycobacterium tuberculosis Infection. (nih.gov)
- The terms used have been based on anatomic location of infection, soft tissue compartment involved, microbiologic and clinical features. (antimicrobe.org)
- All necrotizing soft tissue infections fulfill this definition and have common features in their clinical presentation and diagnosis, and most importantly, all of these infections by definition require surgical debridement. (antimicrobe.org)
- [ 4 ] and the polymicrobial synergistic nature of the infection. (medscape.com)
- AGNB infections are generally polymicrobial. (medscape.com)
- Despite the fact that Peptostreptococci are commensals of the skin and the oral cavity , their presence must not be overlooked when other sites are involved in the infectious process, particularly if a polymicrobial infection is recognized. (symptoma.com)
Treat infections caused1
- Some forms of Doxycycline Focus are used to prevent malaria, to treat anthrax, or to treat infections caused by mites, ticks, or lice. (ndrugs.com)
- Paronychias are localized, superficial infections or abscesses of the perionychium (epidermis bordering the nails). (aafp.org)
- An expert in foodborne and intestinal infections, Cynthia Sears is a professor of medicine and oncology at the Johns Hopkins University School of Medicine as well as a professor of molecular microbiology and immunology at the Bloomberg School of Public Health. (nih.gov)
- In all three hospital categories, the urinary tract was the site most frequently infected, followed by lower respiratory tract or surgical wound infections (Table 3). (cdc.gov)
- Infections of the urinary tract, of surgical wounds, and of the lower respiratory tract accounted for almost three-fourths of the infections in all three hospital categories (Table 4). (cdc.gov)
- Respiratory tract infections caused by Mycoplasma pneumoniae. (ndrugs.com)
- Respiratory tract infections caused by Haemophilus influenzae. (ndrugs.com)
- Osteomyelitis , endocarditis , genitourinary and upper respiratory tract infections , as well as central nervous system infections, have all been described in the literature. (symptoma.com)
- Cats subclinically infected with FCV and feline rhinotracheitis virus may develop oral ulceration with or without respiratory signs following stress or immunosuppression such as with concurrent FIV infection. (vin.com)
- Bacteroides denticanum" is an anaerobic, non- spore -forming, gram-negative bacterium with a rod morphology typical of canine, ovine, and macropod oral flora . (bvsalud.org)
- There is only one report of bloodstream infection caused by "B. denticanum" from a dog bite in human . (bvsalud.org)
- To our knowledge , this is the first report of a human infection caused by "B. denticanum" without a history of animal contact. (bvsalud.org)
Urinary tract infe1
- But tetracycline antibiotics-used commonly to treat urinary tract infections and pink eye -showed up in 60 percent of the downwind samples and 30 percent of the upwind samples, again at much lower levels upwind. (motherjones.com)
- Von Langenbeck (1844) reported the first case of osteomyelitis due to anaerobic bacterial infection. (who.int)
- One hundred and thirty-four (134) cases of pyogenic osteomyelitis were studied for anaerobic infection. (who.int)
- The role of a proper physical examination has an equal value, particularly if endocarditis , osteomyelitis , or CNS infections are suspected. (symptoma.com)
- AGNB promote infection through synergy with their aerobic and anaerobic counterparts and with each other. (medscape.com)
- However, antimicrobial agents used in treating oral infections such as gingivitis and stomatitis should be chosen with the composition of the resident microflora in mind. (vin.com)
- Necrotizing soft tissue infections are infrequent but highly lethal infections. (antimicrobe.org)
- It is estimated that there are between 500-1,500 new cases of necrotizing soft tissue infections per year in the US and a recent epidemiologic population-based study estimated the incidence of necrotizing soft tissue infections to be approximately 0.04/1,000 person-years with information derived from an insurance administrative database from various states in the United States ( 22 ). (antimicrobe.org)
- Necrotizing soft tissue infections occur frequently enough that most primary care physicians, surgeons, and infectious disease specialists will see one or more during a professional career, but are infrequent enough that few will have significant experience and confidence in dealing with them ( 4 ). (antimicrobe.org)
- Since the first description of necrotizing soft tissue infections by Jones, multiple terms have been used to define different kinds of necrotizing infections of the soft tissues ( 17 , 26 , 28 , 39 , 55 ). (antimicrobe.org)
- Table 1 lists the different terms used to refer to necrotizing soft tissue infections. (antimicrobe.org)
- These terms have been used in an attempt to define "different" entities or to classify necrotizing soft tissue infections according to the above variables. (antimicrobe.org)
- Necrotizing soft tissue infections are defined by the presence of a spreading infection in any of the layers of the soft tissues (skin, subcutaneous tissue, superficial fascia, deep fascia, or muscles) which is associated with the presence of necrosis of the layer/s involved and hence requires surgical debridement. (antimicrobe.org)
- The true discriminative information that is essential for the management of soft tissue infections is the presence or absence of a necrotizing component and this should be the focus during the initial assessment of patients with soft tissue infections. (antimicrobe.org)
- However, the general presentation, diagnosis, and management follow the same principles and we encourage the use of the unifying term necrotizing soft tissue infections when referring to all these entities. (antimicrobe.org)
- Although multiple risk factors for necrotizing soft tissue infections have been described, there are no studies specifically addressing this issue. (antimicrobe.org)
- These should be interpreted as conditions that have been associated with necrotizing soft tissue infections but lack data to support them as predictive of necrotizing soft tissue infections occurrence. (antimicrobe.org)
- For example, in the study published by Wall et al, in which 31 patients with necrotizing soft tissue infections were compared to 328 patients with non-necrotizing soft tissue infections, no specific conditions were found to be predictive of necrotizing soft tissue infections, except for intravenous drug use as an etiologic factor (and possibly risk factor too). (antimicrobe.org)
- On the other hand, a more recent study also comparing patients with necrotizing soft tissue infections (n=89) with those with non-necrotizing soft tissue infections (n=225) showed that the former were more likely to have comorbidities and were more commonly associated with the presence of DM (70% vs. 51%, no p value provided) ( 58 ). (antimicrobe.org)
- Primary bacteremia and cutaneous infections accounted for a higher percentage of infections in the large teaching hospitals than in the other hospitals. (cdc.gov)
Soft tissue infections1
- Severe localized pain is typical for joint and other soft tissue infections , whereas high fever and chills , either with or without heart murmurs , are seen in cases of endocarditis . (symptoma.com)
- The overall infection rate (number of hospital-acquired infections per 1,000 patients discharged) was highest in the large teaching hospitals and lowest in the nonteaching hospitals (Table 1). (cdc.gov)
- Stomorgyl is used for infections around the teeth sockets (periodontitis) and related problems in cats and dogs. (justlikechildren.store)
- Two general types of intra-abdominal infection are discussed throughout this chapter: peritonitis and abscess. (antiinfectivemeds.com)
- Concern about asymptomatic PID stems from high rates of PID sequelae such as tubal infertility among women with serologic evidence of previous sexually transmitted infections but no history of overt illness. (cdc.gov)
- To see what role the body's own immune system played in fighting infection compared with gut microbes, the team also studied two strains of mice that have impaired immune systems. (fabresearch.org)
- Any parent knows that newborns are very susceptible to infections in the first year of life, including enteric, or gut, infections ," says Gabriel Nunez, the study's senior author and a pathology professor at the University of Michigan Medical School. (fabresearch.org)
- Compendium of veterinary standard precautions for zoonotic disease prevention in veterinary personnel: National Association of State Public Health Veterinarians Veterinary Infection Control Committee 2010. (cdc.gov)
- and provide a model infection control plan for use in individual veterinary facilities. (cdc.gov)
- BACKGROUND: In the 2003 African monkeypox infection outbreak in the United States, 18 of 71 (25.4%) infected individuals were veterinary personnel. (cdc.gov)
- Veterinary Standard Precautions are guidelines for commonsense infection control practices. (cdc.gov)
- Veterinary Standard Precautions are based on human standard precautions, which are the cornerstone of infection control in human health-care settings. (cdc.gov)
- Uncomplicated urethral, endocervical or rectal infections caused by Chlamydia trachomatis. (ndrugs.com)
- In either case, the best strategies for preventing PID are: a) prevention of lower-genital-tract infection with Chlamydia trachomatis and Neisseria gonorrhoeae among both men and women, b) when this fails, early detection of lower-tract infection followed by prompt and effective treatment. (cdc.gov)
- Preference will be given to investigations of co-infections with known oncogenic agents (excluding human immunodeficiency virus [HIV]) and of co-infections that engender novel opportunities for prevention and treatment. (nih.gov)
- The purpose of this Funding Opportunity Announcement (FOA) is to enhance mechanistic and epidemiologic investigations addressing the roles of co-infection and cancer to shed light on presently unestablished pathways in carcinogenesis that may inform prevention and treatment strategies for infection-related cancers. (nih.gov)
- This drug also used as off label in the treatment of Crohn's disease, Helicobacter pylori infection and as a prophylactic agent after surgery. (pipelinepharma.com)
- Patients receiving therapeutic antibiotics preoperatively are at increased risk for surgical site infections. (bestpracticeinsurgery.ca)