AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
Bacteroides fragilisBacteroidesBacteroides InfectionsBacteria, AnaerobicPrevotella melaninogenicaFusobacteriumClindamycinCefoxitinMicrobial Sensitivity TestsAbscessAnaerobiosisMetronidazoleDrug Resistance, MicrobialAnti-Bacterial AgentsImipenemCefotetanPrevotellaPeptostreptococcusBacteriaBacteria, AerobicAbdominal AbscessNaphthyridinesbeta-LactamasesDNA, BacterialGram-Negative Anaerobic BacteriaFecesSuppurationCephamycinsMoxalactamCephalosporinaseThienamycinsPorphyromonasFluoroquinolonesConjugation, GeneticAnti-Infective AgentsPolysaccharides, BacterialCephalosporinsPenicillanic AcidBacterial InfectionsCeftizoximeBacteroidaceaeGenes, BacterialTetracyclineClostridiumLactamsEscherichia coliBacterial ProteinsGram-Positive Bacteriabeta-LactamsCulture MediaDNA Transposable ElementsAza CompoundsCefmetazoleCedrusEnterotoxinsMetalloendopeptidasesPiperacillinSpecies SpecificityErythromycinMolecular Sequence DataSulbactamClavulanic AcidsPeptococcusFusobacterium InfectionsClavulanic AcidCefotaximeTicarcillinLincomycinColony Count, Microbial
Bacteroides fragilis
Gram-negative bacteria occurring in the lower intestinal tracts of man and other animals. It is the most common species of anaerobic bacteria isolated from human soft tissue infections.
Bacteroides
A genus of gram-negative, anaerobic, rod-shaped bacteria. Its organisms are normal inhabitants of the oral, respiratory, intestinal, and urogenital cavities of humans, animals, and insects. Some species may be pathogenic.
Bacteroides Infections
Infections with bacteria of the genus BACTEROIDES.
Bacteria, Anaerobic
Prevotella melaninogenica
A species of gram-negative, anaerobic, rod-shaped bacteria originally classified within the BACTEROIDES genus. This bacterium has been isolated from the mouth, urine, feces, and infections of the mouth, soft tissue, respiratory tract, urogenital tract, and intestinal tract. It is pathogenic, but usually in association with other kinds of organisms.
Fusobacterium
A genus of gram-negative, anaerobic, rod-shaped bacteria found in cavities of humans and other animals. No endospores are formed. Some species are pathogenic and occur in various purulent or gangrenous infections.
Clindamycin
An antibacterial agent that is a semisynthetic analog of LINCOMYCIN.
Cefoxitin
A semisynthetic cephamycin antibiotic resistant to beta-lactamase.
Microbial Sensitivity Tests
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
Abscess
Accumulation of purulent material in tissues, organs, or circumscribed spaces, usually associated with signs of infection.
Anaerobiosis
The complete absence, or (loosely) the paucity, of gaseous or dissolved elemental oxygen in a given place or environment. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
Metronidazole
A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS. It has also been proposed as a radiation sensitizer for hypoxic cells. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985, p133), this substance may reasonably be anticipated to be a carcinogen (Merck, 11th ed).
Drug Resistance, Microbial
The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
Anti-Bacterial Agents
Substances that reduce the growth or reproduction of BACTERIA.
Imipenem
Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with CILASTATIN, a renal dipeptidase inhibitor.
Cefotetan
A semisynthetic cephamycin antibiotic that is administered intravenously or intramuscularly. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative microorganisms.
Prevotella
A genus of gram-negative, anaerobic, nonsporeforming, nonmotile rods. Organisms of this genus had originally been classified as members of the BACTEROIDES genus but overwhelming biochemical and chemical findings in 1990 indicated the need to separate them from other Bacteroides species, and hence, this new genus was established.
Peptostreptococcus
A genus of gram-positive, anaerobic, coccoid bacteria that is part of the normal flora of humans. Its organisms are opportunistic pathogens causing bacteremias and soft tissue infections.
Bacteria
One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.
Bacteria, Aerobic
Abdominal Abscess
An abscess located in the abdominal cavity, i.e., the cavity between the diaphragm above and the pelvis below. (From Dorland, 27th ed)
Naphthyridines
beta-Lactamases
Enzymes found in many bacteria which catalyze the hydrolysis of the amide bond in the beta-lactam ring. Well known antibiotics destroyed by these enzymes are penicillins and cephalosporins.
DNA, Bacterial
Deoxyribonucleic acid that makes up the genetic material of bacteria.
Gram-Negative Anaerobic Bacteria
A large group of anaerobic bacteria which show up as pink (negative) when treated by the Gram-staining method.
Feces
Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.
Suppuration
A pathologic process consisting in the formation of pus.
Cephamycins
Naturally occurring family of beta-lactam cephalosporin-type antibiotics having a 7-methoxy group and possessing marked resistance to the action of beta-lactamases from gram-positive and gram-negative organisms.
Moxalactam
Broad- spectrum beta-lactam antibiotic similar in structure to the CEPHALOSPORINS except for the substitution of an oxaazabicyclo moiety for the thiaazabicyclo moiety of certain CEPHALOSPORINS. It has been proposed especially for the meningitides because it passes the blood-brain barrier and for anaerobic infections.
Cephalosporinase
Thienamycins
Beta-lactam antibiotics that differ from PENICILLINS in having the thiazolidine sulfur atom replaced by carbon, the sulfur then becoming the first atom in the side chain. They are unstable chemically, but have a very broad antibacterial spectrum. Thienamycin and its more stable derivatives are proposed for use in combinations with enzyme inhibitors.
Porphyromonas
A genus of gram-negative, anaerobic, nonsporeforming, nonmotile rods or coccobacilli. Organisms in this genus had originally been classified as members of the BACTEROIDES genus but overwhelming biochemical and chemical findings indicated the need to separate them from other Bacteroides species, and hence, this new genus was created.
Fluoroquinolones
A group of QUINOLONES with at least one fluorine atom and a piperazinyl group.
Conjugation, Genetic
A parasexual process in BACTERIA; ALGAE; FUNGI; and ciliate EUKARYOTA for achieving exchange of chromosome material during fusion of two cells. In bacteria, this is a uni-directional transfer of genetic material; in protozoa it is a bi-directional exchange. In algae and fungi, it is a form of sexual reproduction, with the union of male and female gametes.
Anti-Infective Agents
Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.
Polysaccharides, Bacterial
Polysaccharides found in bacteria and in capsules thereof.
Cephalosporins
A group of broad-spectrum antibiotics first isolated from the Mediterranean fungus ACREMONIUM. They contain the beta-lactam moiety thia-azabicyclo-octenecarboxylic acid also called 7-aminocephalosporanic acid.
Penicillanic Acid
A building block of penicillin, devoid of significant antibacterial activity. (From Merck Index, 11th ed)
Bacterial Infections
Infections by bacteria, general or unspecified.
Ceftizoxime
A semisynthetic cephalosporin antibiotic which can be administered intravenously or by suppository. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms. It has few side effects and is reported to be safe and effective in aged patients and in patients with hematologic disorders.
Bacteroidaceae
A family of gram-negative bacteria found primarily in the intestinal tracts and mucous membranes of warm-blooded animals. Its organisms are sometimes pathogenic.
Genes, Bacterial
The functional hereditary units of BACTERIA.
Tetracycline
A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.
Clostridium
A genus of motile or nonmotile gram-positive bacteria of the family Clostridiaceae. Many species have been identified with some being pathogenic. They occur in water, soil, and in the intestinal tract of humans and lower animals.
Lactams
Cyclic AMIDES formed from aminocarboxylic acids by the elimination of water. Lactims are the enol forms of lactams.
Escherichia coli
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Bacterial Proteins
Proteins found in any species of bacterium.
Gram-Positive Bacteria
Bacteria which retain the crystal violet stain when treated by Gram's method.
beta-Lactams
Four-membered cyclic AMIDES, best known for the PENICILLINS based on a bicyclo-thiazolidine, as well as the CEPHALOSPORINS based on a bicyclo-thiazine, and including monocyclic MONOBACTAMS. The BETA-LACTAMASES hydrolyze the beta lactam ring, accounting for BETA-LACTAM RESISTANCE of infective bacteria.
Culture Media
Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.
DNA Transposable Elements
Discrete segments of DNA which can excise and reintegrate to another site in the genome. Most are inactive, i.e., have not been found to exist outside the integrated state. DNA transposable elements include bacterial IS (insertion sequence) elements, Tn elements, the maize controlling elements Ac and Ds, Drosophila P, gypsy, and pogo elements, the human Tigger elements and the Tc and mariner elements which are found throughout the animal kingdom.
Aza Compounds
Cefmetazole
A semisynthetic cephamycin antibiotic with a broad spectrum of activity against both gram-positive and gram-negative microorganisms. It has a high rate of efficacy in many types of infection and to date no severe side effects have been noted.
Cedrus
A plant genus in the family PINACEAE, order Pinales, class Pinopsida, division Coniferophyta. It is the source of cedarwood oil. Cedar ordinarily refers to this but also forms part of the name of plants in other genera.
Enterotoxins
Substances that are toxic to the intestinal tract causing vomiting, diarrhea, etc.; most common enterotoxins are produced by bacteria.
Metalloendopeptidases
ENDOPEPTIDASES which use a metal such as ZINC in the catalytic mechanism.
Piperacillin
Semisynthetic, broad-spectrum, AMPICILLIN derived ureidopenicillin antibiotic proposed for PSEUDOMONAS infections. It is also used in combination with other antibiotics.
Species Specificity
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
Erythromycin
A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Sulbactam
A beta-lactamase inhibitor with very weak antibacterial action. The compound prevents antibiotic destruction of beta-lactam antibiotics by inhibiting beta-lactamases, thus extending their spectrum activity. Combinations of sulbactam with beta-lactam antibiotics have been used successfully for the therapy of infections caused by organisms resistant to the antibiotic alone.
Clavulanic Acids
Acids, salts, and derivatives of clavulanic acid (C8H9O5N). They consist of those beta-lactam compounds that differ from penicillin in having the sulfur of the thiazolidine ring replaced by an oxygen. They have limited antibacterial action, but block bacterial beta-lactamase irreversibly, so that similar antibiotics are not broken down by the bacterial enzymes and therefore can exert their antibacterial effects.
Peptococcus
A genus of gram-positive, anaerobic, coccoid bacteria that is part of the normal flora of the mouth, upper respiratory tract, and large intestine in humans. Its organisms cause infections of soft tissues and bacteremias.
Fusobacterium Infections
Infections with bacteria of the genus FUSOBACTERIUM.
Clavulanic Acid
Clavulanic acid and its salts and esters. The acid is a suicide inhibitor of bacterial beta-lactamase enzymes from Streptomyces clavuligerus. Administered alone, it has only weak antibacterial activity against most organisms, but given in combination with other beta-lactam antibiotics it prevents antibiotic inactivation by microbial lactamase.
Cefotaxime
Semisynthetic broad-spectrum cephalosporin.
Ticarcillin
An antibiotic derived from penicillin similar to CARBENICILLIN in action.
Lincomycin
An antibiotic produced by Streptomyces lincolnensis var. lincolnensis. It has been used in the treatment of staphylococcal, streptococcal, and Bacteroides fragilis infections.
Colony Count, Microbial
Enumeration by direct count of viable, isolated bacterial, archaeal, or fungal CELLS or SPORES capable of growth on solid CULTURE MEDIA. The method is used routinely by environmental microbiologists for quantifying organisms in AIR; FOOD; and WATER; by clinicians for measuring patients' microbial load; and in antimicrobial drug testing.

The in-vitro activity of linezolid (U-100766) and tentative breakpoints. (1/843)

The in-vitro activity of linezolid, a novel oxazolidinone, was investigated in comparison with those of amoxycillin, cefuroxime, quinupristin/dalfopristin, trovafloxacin and vancomycin against 420 recent Gram-positive and anaerobic clinical isolates. Linezolid was equally active (MIC90 1 mg/L) against methicillin-susceptible and -resistant Staphylococcus aureus. It demonstrated uniform activity against streptococci and enterococci and no cross-resistance with other agents. The time-kill kinetic data demonstrated that the in-vitro activity of linezolid was predominantly bacteriostatic; slow bactericidal activity was only observed at the higher concentration with streptococci. An increase in inoculum from 10(4) to 10(6) cfu on selected strains had little effect on the MICs (MIC90 within one dilution step) of linezolid and an increase in inoculum from 10(5) to 10(7) cfu/mL had no notable effect on the in-vitro bactericidal activity. A tentative linezolid breakpoint of 2 mg/L was chosen after analysis of distribution of susceptibilities.  (+info)

Bacteroides fragilis toxin 2 damages human colonic mucosa in vitro. (2/843)

BACKGROUND: Strains of Bacteroides fragilis producing a 20 kDa protein toxin (B fragilis toxin (BFT) or fragilysin) are associated with diarrhoea in animals and humans. Although in vitro results indicate that BFT damages intestinal epithelial cells in culture, the effects of BFT on native human colon are not known. AIMS: To examine the electrophysiological and morphological effects of purified BFT-2 on human colonic mucosa in vitro. METHODS: For resistance (R) measurements, colonic mucosa mounted in Ussing chambers was exposed to luminal or serosal BFT-2 (1.25-10 nM) and after four hours morphological damage was measured on haematoxylin and eosin stained sections using morphometry. F actin distribution was assessed using confocal microscopy. RESULTS: Serosal BFT-2 for four hours was four-, two-, seven-, and threefold more potent than luminal BFT-2 in decreasing resistance, increasing epithelial 3H-mannitol permeability, and damaging crypt and surface colonocytes, respectively (p<0.05). Confocal microscopy showed reduced colonocyte F actin staining intensity after exposure to BFT-2. CONCLUSIONS: BFT-2 increases human colonic permeability and damages human colonic epithelial cells in vitro. These effects may be important in the development of diarrhoea and intestinal inflammation caused by B fragilis in vivo.  (+info)

Microbiological and inflammatory effects of murine recombinant interleukin-10 in two models of polymicrobial peritonitis in rats. (3/843)

A protective effect of interleukin-10 (IL-10) against the development of lethal shock has been demonstrated in various animal models. In contrast, the immunosuppressant properties of this mediator have been minimally evaluated in low-mortality models of infections. The clinical, microbiological, and inflammatory effects of murine recombinant IL-10 (mrIL-10) therapy were evaluated in two models of peritonitis in rats, which differed in the degree of severity of peritoneal inflammation 3 days after inoculation of Escherichia coli and Bacteroides fragilis with or without Enterococcus faecalis. The severity of the disease remained unchanged compared to that in control animals. A dose-related decrease in the peritoneal phagocyte count was observed in the treated groups compared to the counts in control animals. The subsequent experiments were performed exclusively in the mixed gram-positive-gram negative model, which exhibits an intense and prolonged inflammatory response with similar criteria. The early effects of mrIL-10 (evaluated 6 h after inoculation), repeated injections of mrIL-10 (four doses injected from 0 to 9 h after bacterial challenge), and pretreatment (two doses injected 6 and 3 h before inoculation) were evaluated. The clinical and microbiological parameters remained unchanged in the treated animals. Decreases in the peritoneal phagocyte count and the peritoneal concentration of tumor necrosis factor were observed following repeated injections of mrIL-10. In summary, our data suggest that mrIL-10 does not worsen the manifestations of sepsis. However, these results need to be confirmed in clinical practice.  (+info)

Antimicrobial resistance patterns of Bacteroides fragilis group organisms in Korea. (4/843)

Antimicrobial resistance patterns of 913 clinical isolates of Bacteroides fragilis group organisms were monitored during an 8-year period in Korea. In general the resistance rates of the non-fragilis B. fragilis group species were higher than those of B. fragilis for all the drugs tested. The rate of resistance to clindamycin remarkably increased and those to some beta-lactam drugs such as piperacillin and cefotaxime also increased. No isolates were found to be resistant to imipenem, metronidazole, or chloramphenicol. beta-lactam and beta-lactamase inhibitor combinations and cefoxitin were more active than the other beta-lactams. Therefore, these agents may be considered when empirical selection of antimicrobial agents is required to treat severe anaerobic infections.  (+info)

Diversity of bacteroides fragilis strains in their capacity to recover phages from human and animal wastes and from fecally polluted wastewater. (5/843)

Great differences in capability to detect bacteriophages from urban sewage of the area of Barcelona existed among 115 strains of Bacteroides fragilis. The capability of six of the strains to detect phages in a variety of feces and wastewater was studied. Strains HSP40 and RYC4023 detected similar numbers of phages in urban sewage and did not detect phages in animal feces. The other four strains detected phages in the feces of different animal species and in wastewater of both human and animal origin. Strain RYC2056 recovered consistently higher counts than the other strains and also detected counts ranging from 10(1) to approximately 10(3) phages per ml in urban sewage from different geographical areas. This strain detected bacteriophages in animal feces even though their relative concentration with respect to the other fecal indicators was significantly lower in wastewater polluted with animal feces than in urban sewage.  (+info)

Bacteroides fragilis transfer factor Tn5520: the smallest bacterial mobilizable transposon containing single integrase and mobilization genes that function in Escherichia coli. (6/843)

Many bacterial genera, including Bacteroides spp., harbor mobilizable transposons, a class of transfer factors that carry genes for conjugal DNA transfer and, in some cases, antibiotic resistance. Mobilizable transposons are capable of inserting into and mobilizing other, nontransferable plasmids and are implicated in the dissemination of antibiotic resistance. This paper presents the isolation and characterization of Tn5520, a new mobilizable transposon from Bacteroides fragilis LV23. At 4,692 bp, it is the smallest mobilizable transposon reported from any bacterial genus. Tn5520 was captured from B. fragilis LV23 by using the transfer-deficient shuttle vector pGAT400DeltaBglII. The termini of Tn5520 contain a 22-bp imperfect inverted repeat, and transposition does not result in a target site repeat. Tn5520 also demonstrates insertion site sequence preferences characterized by A-T-rich nucleotide sequences. Tn5520 has been sequenced in its entirety, and two large open reading frames whose predicted protein products exhibit strong sequence similarity to recombinase-integrase enzymes and mobilization proteins, respectively, have been identified. The transfer, mobilization, and transposition properties of Tn5520 have been studied, revealing that Tn5520 mobilizes plasmids in both B. fragilis and Escherichia coli at high frequency and also transposes in E. coli.  (+info)

TNF-binding protein ameliorates inhibition of skeletal muscle protein synthesis during sepsis. (7/843)

We examined the effects of TNF-binding protein (TNFBP) on regulatory mechanisms of muscle protein synthesis during sepsis in four groups of rats: Control; Control+TNFBP; Septic; and Septic+TNFBP. Saline (1. 0 ml) or TNFBP (1 mg/kg, 1.0 ml) was injected daily starting 4 h before the induction of sepsis. The effect of TNFBP on gastrocnemius weight, protein content, and the rate of protein synthesis was examined 5 days later. Sepsis reduced the rate of protein synthesis by 35% relative to controls by depressing translational efficiency. Decreases in protein synthesis were accompanied by similar reductions in protein content and muscle weight. Treatment of septic animals with TNFBP for 5 days prevented the sepsis-induced inhibition of protein synthesis and restored translational efficiency to control values. TNFBP treatment of Control rats for 5 days was without effect on muscle protein content or protein synthesis. We also assessed potential mechanisms regulating translational efficiency. The phosphorylation state of p70(S6) kinase was not altered by sepsis. Sepsis reduced the gastrocnemius content of eukaryotic initiation factor 2Bepsilon (eIF2Bepsilon), but not eIF2alpha. The decrease in eIF2Bepsilon content was prevented by treatment of septic rats with TNFBP. TNFBP ameliorates the sepsis-induced changes in protein metabolism in gastrocnemius, indicating a role for TNF in the septic process. The data suggest that TNF may impair muscle protein synthesis by reducing expression of specific initiation factors during sepsis.  (+info)

Structural consequences of the active site substitution Cys181 ==> Ser in metallo-beta-lactamase from Bacteroides fragilis. (8/843)

The metallo-beta-lactamases require divalent cations such as zinc or cadmium for hydrolyzing the amide bond of beta-lactam antibiotics. The crystal structure of the Zn2+ -bound enzyme from Bacteroides fragilis contains a binuclear zinc center in the active site. A hydroxide, coordinated to both zinc atoms, is proposed as the moiety that mounts the nucleophilic attack on the carbonyl carbon atom of the beta-lactam bond of the substrate. It was previously reported that the replacement of the active site Cys181 by a serine residue severely impaired catalysis while atomic absorption measurements indicated that binding of the two zinc ions remained intact. Contradicting data emerge from recent mass spectrometry results, which show that only a single zinc ion binds to the C181S metallo-beta-lactamase. In the current study, the C181S mutant enzyme was examined at the atomic level by determining the crystal structure at 2.6 A resolution. The overall structure of the mutant enzyme is the same as that of the wild-type enzyme. At the mutation site, the side chain of Ser181 occupies the same position as that of the side chain of Cys181 in the wild-type protein. One zinc ion, Zn1, is present in the crystal structure; however, the site of the second zinc ion, Zn2 is unoccupied. A water molecule is associated with Zn1, reminiscent of the hydroxide seen in the structure of the wild-type enzyme but farther from the metal. The position of the water molecule is off the plane of the carboxylate group of Asp103; therefore, the water molecule may be less nucleophilic than a water molecule which is coplanar with the carboxylate group.  (+info)

Molecular evolution of the pathogenicity island of enterotoxigenic Bacteroides fragilis strains<...Molecular evolution of the pathogenicity island of enterotoxigenic Bacteroides fragilis strains<...
TY - JOUR. T1 - Molecular evolution of the pathogenicity island of enterotoxigenic Bacteroides fragilis strains. AU - Franco, Augusto A.. AU - Cheng, Rodney K.. AU - Chung, Gyung Tae. AU - Wu, Shaoguang. AU - Oh, Hee Bok. AU - Sears, Cynthia Louise. PY - 1999/11. Y1 - 1999/11. N2 - Enterotoxigenic Bacteroides fragilis (ETBF) strains, which produce a 20- kDa zinc metalloprotease toxin (BFT), have been associated with diarrheal disease in animals and young children. Studying a collection of ETBF and nontoxigenic B. fragilis (NTBF) strains, we found that bft and a second metalloprotease gene (mpII) are contained in an ~6-kb pathogenicity island (termed B. fragilis pathogenicity island or BfPAI) which is present exclusively in all 113 ETBF strains tested (pattern I). Of 191 NTBF strains, 100 (52%) lack both the BfPAI and at least a 12-kb region flanking BfPAI (pattern II), and 82 of 191 NTBF strains (43%) lack the BfPAI but contain the flanking region (pattern III). The nucleotide sequence flanking ...
https://jhu.pure.elsevier.com/en/publications/molecular-evolution-of-the-pathogenicity-island-of-enterotoxigeni-3
Simultaneous detection of Bacteroides fragilis group species by leuB -directed PCR - Arimochi, Hideki - Authors - Tokushima...Simultaneous detection of Bacteroides fragilis group species by leuB -directed PCR - Arimochi, Hideki - Authors - Tokushima...
Bacteroides species, saccharolytic Gram-negative obligate anaerobes, are frequently isolated from human infections such as peritonitis, abscesses and bacteremia. Among the species in the genus Bacteroides, thespecies called B. fragilis group areparticularly involved inhuman infections andaremedically important because they account for a major part of anaerobic isolates from clinical specimens. The purpose of this study was to develop PCR primers that specifically and simultaneously amplify theβ-isopropylmalate dehydrogenase gene leuB in B. fragilis group species. We determined partial nucleotide sequences of leuB genes and compared them in seventeen strains of nine B. fragilis group species, and the regions that are conserved among Bacteroides strains but different from other species were used as a B. fragilis group-specific PCR primer set, BacLBF-BacLBR. Specificity tests of the primer set using 52 phenotypically characterized strains and 75 isolates from rat feces showed only one case each ...
https://repo.lib.tokushima-u.ac.jp/en/list/author-page/60214/item/110763
A single chromosome assembly of Bacteroides fragilis strain BE1 from Illumina and MinION nanopore sequencing data<...A single chromosome assembly of Bacteroides fragilis strain BE1 from Illumina and MinION nanopore sequencing data<...
TY - JOUR. T1 - A single chromosome assembly of Bacteroides fragilis strain BE1 from Illumina and MinION nanopore sequencing data. AU - Risse, Judith. AU - Thomson, Marian. AU - Patrick, Sheila. AU - Blakely, Garry. AU - Koutsovoulos, Georgios. AU - Blaxter, Mark. AU - Watson, Mick. PY - 2015/12/4. Y1 - 2015/12/4. N2 - BACKGROUND: Second and third generation sequencing technologies have revolutionised bacterial genomics. Short-read Illumina reads result in cheap but fragmented assemblies, whereas longer reads are more expensive but result in more complete genomes. The Oxford Nanopore MinION device is a revolutionary mobile sequencer that can produce thousands of long, single molecule reads.RESULTS: We sequenced Bacteroides fragilis strain BE1 using both the Illumina MiSeq and Oxford Nanopore MinION platforms. We were able to assemble a single chromosome of 5.18 Mb, with no gaps, using publicly available software and commodity computing hardware. We identified gene rearrangements and the state of ...
https://www.research.ed.ac.uk/en/publications/a-single-chromosome-assembly-of-bacteroides-fragilis-strain-be1-f
Bacteroides fragilis Enterotoxin Gene Sequences in Patients with Inflammatory Bowel Disease - Volume 6, Number 2-April 2000 -...Bacteroides fragilis Enterotoxin Gene Sequences in Patients with Inflammatory Bowel Disease - Volume 6, Number 2-April 2000 -...
We identified enterotoxigenic Bacteroides fragilis in stool specimens of patients with inflammatory bowel disease and other gastrointestinal disorders. The organism was detected in 11 (13.2%) of 83 patients with inflammatory bowel disease. Of 57 patients with active disease, 19.3% were toxin positive; none of those with inactive disease had specimens positive for enterotoxigenic Bacteroides fragilis gene sequences.
https://wwwnc.cdc.gov/eid/article/6/2/00-0210_article
National Survey on the Susceptibility of Bacteroides fragilis Group: Report and Analysis of Trends for 1997-2000 : Clinical...National Survey on the Susceptibility of Bacteroides fragilis Group: Report and Analysis of Trends for 1997-2000 : Clinical...
The results of a multicenter US survey using the National Committee for Clinical Laboratory Standards currently recommended methodology for measuring in vitro susceptibility of 2673 isolates of Bacteroides fragilis group species were compared from 1997 to 2000. The test panel consisted of 14 antibiotics: 3 carbapenems, 3 β-lactam-β-lactamase inhibitors, 3 cephamycins, 2 fluoroquinolones, clindamycin, chloramphenicol, and metronidazole. Declines in the geometric mean minimum inhibitory concentrations were seen with imipenem, meropenem, ampicillin-sulbactam, and the cephamycins. Increased geometric means were observed with the fluoroquinolones and were usually accompanied by an increase in resistance rates. Bacteroides distasonis shows the highest resistance rates among β-lactam antibiotics, whereas Bacteroides vulgatus shows the highest resistance levels among fluoroquinolones. B. fragilis shows the lowest resistance rates for all antibiotics. All strains were susceptible to chloramphenicol ...
http://oxfordindex.oup.com/view/10.1086/341934
Examination of cfiA-mediated carbapenem resistance in Bacteroides fragilis strains from a European antibiotic susceptibility...Examination of cfiA-mediated carbapenem resistance in Bacteroides fragilis strains from a European antibiotic susceptibility...
Of 1284 Bacteroides strains collected in Europe in 2000 for antibiotic susceptibility surveillance, 65 isolates displayed imipenem minimum inhibitory concentrations (MICs) , or =1 mg/L and were chosen for a thorough analysis of their resistance mechanism. Twenty-five of the isolates were positive for the cfiA carbapenem resistance gene. The resistance rates were 0.8% and 1.3% for imipenem and meropenem, respectively. In six of the strains, insertion sequence (IS) elements (IS613, IS614B, IS1186 and IS1187) activated the cfiA gene. However, other strains displayed at least elevated carbapenem MICs or were carbapenem resistant and produced measurable carbapenemase activities but did not harbour IS elements in the region upstream of the cfiA gene. The major determinant of carbapenem resistance in Bacteroides fragilis is production of CfiA metallo-beta-lactamase via activation of the cfiA gene by IS elements (higher level resistance) or by activation of its putative own promoter.. ...
http://umu.diva-portal.org/smash/record.jsf?pid=diva2:245989
GigaDB Dataset - DOI 10.5524/100177 - Supporting data for A single chromosome assembly of Bacteroides fragilis strain BE1 from...GigaDB Dataset - DOI 10.5524/100177 - Supporting data for A single chromosome assembly of Bacteroides fragilis strain BE1 from...
Second and third generation sequencing technologies have revolutionised bacterial genomics. Short-read Illumina reads result in cheap but fragmented assemblies, whereas longer reads are more expensive but result in more complete genomes. The Oxford Nanopore MinION device is a revolutionary mobile sequencer that can produce thousands of long, single molecule reads.|br| We sequenced |em|Bacteroides fragilis|/em| strain BE1 using both the Illumina MiSeq and Oxford Nanopore MinION platforms. We were able to assemble a single chromosome of 5.18 Mb, with no gaps, using publicly available software and commodity computing hardware. We identified gene rearrangements and the state of invertible promoters in the strain. |br| The final assembly and annotations are available from the public archives (EBI/NCBI/DDBJ) and additionally here we provide the assemblies done for comparison from each of the individual technologies and the alignments of the original raw reads to the final assembly.|br|
http://microme.genomics.org.cn/dataset/100177
Cellular immunity to Bacteroides fragilis capsular polysaccharide. | JEMCellular immunity to Bacteroides fragilis capsular polysaccharide. | JEM
The polysaccharide capsule of Bacteroides fragilis has been shown to be important in the virulence of the organism. The capsular polysaccharide (CP) of B. fragilis has been extensively purified. Using a murine model of intraabdominal abscess formation, we have been able to demonstrate cellular immunity to the capsular polysaccharide of B. fragilis. Immunization of C57BL/10J mice with the CP over 5 wk prevents abscess formation when the mice are challenged with B. fragilis intraperitoneally. This immunity can be transferred to naive mice with spleen cells from immune animals. The immune cells bear Thy-1.2 and Ly-2.2 antigens. The immune response has been shown to be antigen specific, but not H-2 restricted. The possibility that these immune cells are suppressor T cells is discussed. The experimental system presented provides a model for the examination of the cellular interactions responsible for abscess formation and the cellular response to bacterial pathogens. ...
http://jem.rupress.org/content/155/4/1188
Bacteroides fragilis enterotoxin gene sequences in patients with inflammatory bowel diseaseBacteroides fragilis enterotoxin gene sequences in patients with inflammatory bowel disease
We identified enterotoxigenic Bacteroides fragilis in stool specimens of patients with inflammatory bowel disease and other gastrointestinal disorders. The organism was detected in 11 (13.2%) of 83 patients with inflammatory bowel disease. Of 57 patients with active disease, 19.3% were toxin positiv …
https://pubmed.ncbi.nlm.nih.gov/10756151/?dopt=Abstract
A recent fixation of cfiA genes in a monophyletic cluster of Bacteroides fragilis is correlated with the presence of multiple...A recent fixation of cfiA genes in a monophyletic cluster of Bacteroides fragilis is correlated with the presence of multiple...
Small-subunit ribosomal DNA sequences of 16 strains of Bacteroides fragilis were determined and compared with previously published sequences. Three phylogenetic methods (the neighbor-joining, maximum-likelihood, and maximum-parsimony methods) as well as a bootstrap analysis were used to assess the robustness of each topology. All phylogenetic analyses demonstrated that the B. fragilis strains were clearly divided into two robust monophyletic units which corresponded to the cfiA-negative and cfiA-positive groups. Strains of two previously identified DNA homology groups separated similarly into the two monophyletic units. According to the intensity of the hybridization signal with a cfiA probe, the cfiA-positive cluster could be further divided into two groups. This difference might reflect the existence of two, probably closely related cfiA-type genes. In the strongly hybridizing cfiA-positive strains, the gene is capable of conferring high-level resistance to the carbapenems and to most ...
https://jb.asm.org/content/178/7/1914
EC 2.4.1.281EC 2.4.1.281
Accepted name: 4-O-β-D-mannosyl-D-glucose phosphorylase. Reaction: 4-O-β-D-mannopyranosyl-D-glucopyranose + phosphate = D-glucose + α-D-mannose 1-phosphate. Glossary: 4-O-β-D-mannopyranosyl-D-glucopyranose = β-D-mannopyranosyl-(1→4)-D-glucopyranose. Other name(s): mannosylglucose phosphorylase. Systematic name: 4-O-β-D-mannopyranosyl-D-glucopyranose:phosphate α-D-mannosyltransferase. Comments: This enzyme forms part of a mannan catabolic pathway in the anaerobic bacterium Bacteroides fragilis NCTC 9343.. Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: References:. 1. Senoura, T., Ito, S., Taguchi, H., Higa, M., Hamada, S., Matsui, H., Ozawa, T., Jin, S., Watanabe, J., Wasaki, J. and Ito, S. New microbial mannan catabolic pathway that involves a novel mannosylglucose phosphorylase. Biochem. Biophys. Res. Commun. 408 (2011) 701-706. [PMID: 21539815]. ...
http://www.sbcs.qmul.ac.uk/iubmb/enzyme/EC2/4/1/281.html
The dissemination of C10 cysteine protease genes in Bacteroides fragilis by mobile genetic elements | BMC Microbiology | Full...The dissemination of C10 cysteine protease genes in Bacteroides fragilis by mobile genetic elements | BMC Microbiology | Full...
Bacteroides fragilis is a Gram-negative member of the normal human gut microbiota. The Bacteroidetes constitutes one of the major bacterial phyla in the healthy human gut [1]. However, B. fragilis is also an important opportunistic pathogen, and it is the most frequently isolated anaerobic bacterium in clinical specimens, including abdominal abscesses and bloodstream infections [2]. Indeed, while B. fragilis accounts for only 4 to 13% of the normal human fecal microbiota, it is responsible for 63 to 80% of Bacteroides infections [3]. Only a few virulence factors have been described for B. fragilis, with the best characterized being the polysaccharide (PS) capsule [4] and a secreted metalloprotease, fragilysin [5]. The capsule, which displays antigenic variation, promotes the formation of abscesses [4], and the reduction of pro-inflammatory responses to B. fragilis[4, 6]. The metalloprotease fragilysin, which has been linked to diarrheal disease [5], has activity against the zonula junctions ...
https://0-bmcmicrobiol-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/1471-2180-10-122
leuS - Leucine--tRNA ligase - Bacteroides fragilis (strain YCH46) - leuS gene & proteinleuS - Leucine--tRNA ligase - Bacteroides fragilis (strain YCH46) - leuS gene & protein
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
http://www.uniprot.org/uniprot/Q64MG4
Stat3 activation in murine colitis induced by enterotoxigenic Bacteroides fragilisStat3 activation in murine colitis induced by enterotoxigenic Bacteroides fragilis
ETBF rapidly induces immune cell pStat3, which is independent of epithelial pStat3. This occurs before ETBF-induced mucosal permeability, suggesting that ETBF, likely through B. fragilis toxin and its action on the colonic epithelial cell, triggers mucosal immune cell Stat3 activation. Peak mucosal …
https://pubmed.ncbi.nlm.nih.gov/24704822/?dopt=Abstract
Structures of Bacteroides fragilis uridine 5-diphosphate-N-acetylglucosamine (UDP-GlcNAc) acyltransferase (BfLpxA).Structures of Bacteroides fragilis uridine 5-diphosphate-N-acetylglucosamine (UDP-GlcNAc) acyltransferase (BfLpxA).
Author(s): Ngo, Alice; Fong, Kai T; Cox, Daniel L; Chen, Xi; Fisher, Andrew J | Abstract: Uridine 5-diphosphate-N-acetylglucosamine (UDP-GlcNAc) acyltransferase (LpxA) catalyzes a reversible reaction for adding an O-acyl group to the GlcNAc in UDP-GlcNAc in the first step of lipid A biosynthesis. Lipid A constitutes a major component of lipopolysaccharides, also referred to as endotoxins, which form the outer monolayer of the outer membrane of Gram-negative bacteria. Ligand-free and UDP-GlcNAc-bound crystal structures of LpxA from Bacteroides fragilis NCTC 9343, the most common pathogenic bacteria found in abdominal abscesses, have been determined and are presented here. The enzyme crystallizes in a cubic space group, with the crystallographic threefold axis generating the biological functional homotrimer and with each monomer forming a nine-rung left-handed β-helical (LβH) fold in the N-terminus followed by an α-helical motif in the C-terminus. The structure is highly similar to LpxA from other
https://escholarship.org/uc/item/24q4m1qm
A unique homologue of the eukaryotic protein-modifier ubiquitin present in the bacterium Bacteroides fragilis, a predominant...A unique homologue of the eukaryotic protein-modifier ubiquitin present in the bacterium Bacteroides fragilis, a predominant...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
https://www.ncbi.nlm.nih.gov/pubmed/21885481?dopt=Abstract
The dissemination of C10 cysteine protease genes in Bacteroides fragilis by mobile genetic elements | BMC Microbiology | Full...The dissemination of C10 cysteine protease genes in Bacteroides fragilis by mobile genetic elements | BMC Microbiology | Full...
The C10 family of cysteine proteases includes enzymes that contribute to the virulence of bacterial pathogens, such as SpeB in Streptococcus pyogenes. The presence of homologues of cysteine protease genes in human commensal organisms has not been examined. Bacteroides fragilis is a member of the dominant Bacteroidetes phylum of the human intestinal microbiota, and is a significant opportunistic pathogen. Four homologues of the streptococcal virulence factor SpeB were identified in the B. fragilis genome. These four protease genes, two were directly contiguous to open reading frames predicted to encode staphostatin-like inhibitors, with which the protease genes were co-transcribed. Two of these protease genes are unique to B. fragilis 638R and are associated with two large genomic insertions. Gene annotation indicated that one of these insertions was a conjugative Tn-like element and the other was a prophage-like element, which was shown to be capable of excision. Homologues of the B. fragilis C10
https://bmcmicrobiol.biomedcentral.com/articles/10.1186/1471-2180-10-122/tables/2
Occurrence of Bacteroides fragilisEnterotoxin Gene-Carrying Strains in Germany and the United States | Journal of Clinical...Occurrence of Bacteroides fragilisEnterotoxin Gene-Carrying Strains in Germany and the United States | Journal of Clinical...
Bacteroides fragilis is an obligately anaerobic bacterium that can be isolated from a variety of human infections (2). In the mid-1980s it was recognized that some strains produce an enterotoxin (ET) that can cause acute diarrhea in humans, young lambs, calves, pigs, and foals (6,7). Enterotoxigenic B. fragilis (ETBF) strains have also been isolated from the feces of children with diarrhea (9). Kato et al. (4) showed that B. fragilis blood culture isolates were more likely to be ETBF and suggested that ETBF strains are more virulent than enterotoxin-negative strains. Recently, the enterotoxin gene of B. fragilis has been cloned, sequenced, and identified as producing a zinc metalloprotease of 44.4 kDa (5).. In order to determine the relative frequency of ETBF in different geographic locations, 93 B. fragilis clinical isolates from Germany and Southern California were analyzed. Two PCR assays were used to detect two independent genetic sequences of the B. fragilis enterotoxin gene. In addition, ...
https://jcm.asm.org/content/38/5/1996?ijkey=9ba31eb8be6b5f9896dda3ce665758f940ccc0bb&keytype2=tf_ipsecsha
Cloning and expression of the Bacteroides fragilis TAL2480 neuraminidase gene, nanH, in Escherichia coli. | Journal of...Cloning and expression of the Bacteroides fragilis TAL2480 neuraminidase gene, nanH, in Escherichia coli. | Journal of...
We have cloned the Bacteroides fragilis TAL2480 neuraminidase (NANase) structural gene, nanH, in Escherichia coli. This was accomplished by using the cloning shuttle vector pJST61 and a partial Sau3A library of TAL2480 chromosomal inserts created in E. coli. The library was mobilized into the NANase-deficient B. fragilis TM4000 derivative TC2. NANase-producing colonies were enriched by taking advantage of the inability of TC2, but not the wild-type of NANase+ revertant, to grow in vitro in fluid aspirated from the rat granuloma pouch. Plasmids pJST61-TCN1 and pJST61-TCN3, containing inserts of 9.1 and 4.5 kilobases (kb), respectively, were found in the TC2 derivatives that grew in the rat pouch medium. In B. fragilis, NANase production from the two plasmids was inducible by free N-acetylneuraminic acid or sialic acid-containing substrates, just as in the parental TAL2480 strain. However, when these plasmids were transferred back to E. coli, NANase activity was barely detectable. A 3.5-kb portion ...
https://jb.asm.org/content/172/5/2594?ijkey=961570891a845b7f133830f87f28bc50bc4967d6&keytype2=tf_ipsecsha
Bacteroides fragilis (Veillon and Zuber) Castellani and Chalmers ATCCBacteroides fragilis (Veillon and Zuber) Castellani and Chalmers ATCC
Bacteroides fragilis ATCC ® 25285™ Designation: VPI 2553 TypeStrain=True Application: Media testing Quality control strain Susceptibility testing Quality control strain for BBL and MicroScan ® products Pharmaceutical and Personal Care
https://www.atcc.org/en/Products/Cells_and_Microorganisms/Fungi_and_Yeast/Quality_Control_Strains/Pharmaceutical_and_Personal_Care/25285.aspx?p=1&rel=%7B0%7D
Bacteroides fragilis (Veillon and Zuber) Castellani and Chalmers ATCCBacteroides fragilis (Veillon and Zuber) Castellani and Chalmers ATCC
Bacteroides fragilis ATCC ® 25285™ Designation: VPI 2553 TypeStrain=True Application: Media testing Quality control strain Susceptibility testing Quality control strain for BBL and MicroScan ® products Pharmaceutical and Personal Care
https://www.atcc.org/en/Products/Cells_and_Microorganisms/Fungi_and_Yeast/Quality_Control_Strains/Pharmaceutical_and_Personal_Care/25285.aspx
Biological activity of Bacteroides fragilis]. - MyScienceWorkBiological activity of Bacteroides fragilis]. - MyScienceWork
[Biological activity of Bacteroides fragilis].: The investigation was performed with 9 strains of B. fragilis isolated from pregnant women in their 38th week of
https://www.mysciencework.com/publication/show/biological-activity-bacteroides-fragilis-aad9159f
Alterations in opsonophagocytic killing by neutrophils of Bacteroides fragilis associated with animal and laboratory passage:...Alterations in opsonophagocytic killing by neutrophils of Bacteroides fragilis associated with animal and laboratory passage:...
Electron microscopic studies of laboratory-passaged and animal-passaged isolates of Bacteroides fragilis showed significantly more capsular material around the latter. This observation correlated with increased survival of animal-passaged bacteria in rabbit intraperitoneal chambers and increased resistance to phagocytosis and opsonophagocytic killing by neutrophils. With an initial inoculum of 2.5 x 10(6) colony-forming units/ml, the number of bacteria surviving after incubation for 2 hr with neutrophils and pooled normal human serum was significantly (P less than 0.01) greater for animal-passaged than for laboratory-passaged bacteria. Neutrophil uptake of 14C-labeled animal-passaged and laboratory-passaged bacteria after incubation for 20 min was 45% and 63%, respectively (P less than 0.05). No significant difference in survival was found between animal-passaged and laboratory-passaged isolates of Bacteroides thetaiotaomicron. These findings suggest that on mechanism whereby the capsule of B. ...
https://www.meta.org/papers/alterations-in-opsonophagocytic-killing-by/7054319
The intestinal microbiome of fish under starvation | BMC Genomics | Full TextThe intestinal microbiome of fish under starvation | BMC Genomics | Full Text
Significantly more reads were assigned to the Bacteroidetes phylum in the experimental sample (36%) as compared to the control sample (8.2%). At the class level, Bacteroidia (1.3% in the control sample vs. 24.4% in the experimental sample) and Sphingobacteria (1.1% in the control sample vs. 7.8% in the experimental sample) contributed to higher percentages of the microbiota in the experimental sample than in the control sample. The significant elevation of Bacteroidetes in the intestinal community of the starved seabass sample is in agreement with some other studies [2, 34, 35] on dietary shifts. For example, in mice [34], fasting was associated with a significant increase in the proportional representation of the Bacteroidetes [from 20.6% (fed) to 42.3% (fasted)]. Bacteroides with a much larger genome size (e.g., Bacteroides fragilis Strain NCTC9343: 5,205,140 bp) are normally mutualistic in the animal gastrointestinal flora. A large part of the proteins made by the Bacteroides genome are able ...
https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-15-266
In vitro and in vivo antibacterial activities of AM-1155, a new 6-fluoro-8-methoxy quinolone. | Antimicrobial Agents and...In vitro and in vivo antibacterial activities of AM-1155, a new 6-fluoro-8-methoxy quinolone. | Antimicrobial Agents and...
AM-1155 is a new quinolone with a wide spectrum of antibacterial activity against various bacteria including anaerobes and Mycoplasma pneumoniae. AM-1155 was 2- to 16-fold more active than ciprofloxacin and ofloxacin against Staphylococcus aureus including methicillin-resistant strains, Staphylococcus epidermidis, Streptococcus pneumoniae, and Enterococcus faecalis; its MICs for 90% of strains tested were 0.10 to 0.78 micrograms/ml. The activity of AM-1155 was comparable to that of ciprofloxacin against members of the family Enterobacteriaceae, Branhamella catarrhalis, Haemophilus influenzae, and Neisseria gonorrhoeae, but was fourfold less than that of ciprofloxacin against Pseudomonas aeruginosa. Against Xanthomonas maltophilia, Acinetobacter calcoaceticus, and Campylobacter jejuni, AM-1155 was two- to fourfold more active than ciprofloxacin. At a concentration of 1.56 micrograms/ml, AM-1155 inhibited 90% of Bacteroides fragilis strains tested; its activity was 8- to 10-fold higher than those ...
https://aac.asm.org/content/36/10/2108?ijkey=4f8de8880b9ffa45cca3106f19b715739c3e64ed&keytype2=tf_ipsecsha
Friend and Foe Alike | ScienceFriend and Foe Alike | Science
The immune system protects against infection and disease, but there are numerous examples where it has switched sides, as in autoimmune diseases and in cancer. Cells become cancerous when they acquire genetic mutations that enable them to evade the regular controls on growth. In addition, stomach (Helicobacter pylori) and liver (hepatitis viruses B and C) cancers have been associated with infection-induced inflammation, which involves immune cells, such as macrophages, and inflammation signaling molecules that can promote tumorigenesis. Research on the mechanisms of inflammation-induced carcinogenesis has focused mainly on the innate branch of the immune system, primarily the NF-κB intracellular signaling pathway.. Colorectal cancer has been linked to inflammation of the colon (colitis), which can be caused by bacterial infections. Wu et al. have found that the human bacterium enterotoxigenic Bacteroides fragilis (ETBF), which induces colitis, can promote colon cancer in a mouse model of the ...
http://science.sciencemag.org/content/325/5948/1601.2
Antibiotic resistance of anaerobic bacteria of the Bacteroides fragilisAntibiotic resistance of anaerobic bacteria of the Bacteroides fragilis
The results of the study demonstrated a decrease in the sensitivity of bacteria in the B.fragilis group to modern anti-anaerobic drugs: cefoxitin, clindamycin, moxifloxacin, imipenem, piperacillin / tazobactam and metronidazole.
https://buyantibiotics24h.net/blog/antibiotic-resistance-of-anaerobic-bacteria-of-the-bacteroides-fragilis/
Items where Author is Alizadeh, Naser - Repository of Research and Investigative InformationItems where Author is Alizadeh, Naser - Repository of Research and Investigative Information
Akhi, Mohammad Taghi and Jedari Seifi, Sirus and Asgharzadeh, Mohammad and Ahangarzadeh Rezaee, Mohammad and Abdoli Oskuei, Shahram and Pirzadeh, Tahereh and Memar, Mohammad Yousef and Alizadeh, Naser and Seifi Yarijan Sofla, Hasan (2016) Role of Enterotoxigenic Bacteroides fragilis in Children Less Than 5 Years of Age with Diarrhea in Tabriz, Iran. Jundishapur Journal of Microbiology, Inpres (Inpres). ISSN 2008-3645 Akhi, Mohammad Taghi and Ghotaslou, Reza and Beheshtirouy, Samad and Asgharzadeh, Mohammad and Pirzadeh, Tahereh and Asghari, Babak and Alizadeh, Naser and Toloue Ostadgavahi, Ali and Sorayaei Somesaraei, Vida and Memar, Mohammad Yousef (2015) Antibiotic Susceptibility Pattern of Aerobic and Anaerobic Bacteria Isolated From Surgical Site Infection of Hospitalized Patients. Jundishapur Journal of Microbiology, 8 (7). ISSN 2008-3645 Akhi, Mohammad Taghi and Ghotaslou, Reza and Beheshtirouy, Samad and Asgharzadeh, Mohammad and Pirzadeh, Tahereh and Asghari, Babak and Alizadeh, Naser ...
http://eprints.ajums.ac.ir/view/creators/Alizadeh=3ANaser=3A=3A.html
Research Labs and Institutes | Johns Hopkins MedicineResearch Labs and Institutes | Johns Hopkins Medicine
Work in the Cynthia Sears Laboratory focuses on the bacterial contributions to the development of human colon cancer and the impact of the microbiome on other cancers and the therapy of cancer. The current work involves mouse and human studies to define how enterotoxigenic Bacteroides fragilis, pks+ Escherichia coli, Fusobacterium nucleatum, biofilms and the colonic microbiota induce chronic colonic inflammation and colon cancer. Prospective human studies of the microbiome and biofilms in screening colonoscopy are in progress as are studies to determine if and how the microbiome impacts the response of individuals with cancer to immunotherapy and other cancer therapies ...
https://www.hopkinsmedicine.org/research/research_lab_results.html?query=enterotoxigenic%20Bacteroides%20fragilis&pagesize=10&page=1&firstLetter=
Items where Author is Abdoli Oskuei, Shahram - Repository of Research and Investigative InformationItems where Author is Abdoli Oskuei, Shahram - Repository of Research and Investigative Information
Akhi, Mohammad Taghi and Jedari Seifi, Sirus and Asgharzadeh, Mohammad and Ahangarzadeh Rezaee, Mohammad and Abdoli Oskuei, Shahram and Pirzadeh, Tahereh and Memar, Mohammad Yousef and Alizadeh, Naser and Seifi Yarijan Sofla, Hasan (2016) Role of Enterotoxigenic Bacteroides fragilis in Children Less Than 5 Years of Age with Diarrhea in Tabriz, Iran. Jundishapur Journal of Microbiology, Inpres (Inpres). ISSN 2008-3645 ...
http://eprints.ajums.ac.ir/view/creators/Abdoli_Oskuei=3AShahram=3A=3A.html
Comparison of the Giemsa C-banded karyotypes of the three subspecies of Psathyrostachys fragilis, subspp. villosus (2x),...Comparison of the Giemsa C-banded karyotypes of the three subspecies of Psathyrostachys fragilis, subspp. villosus (2x),...
The karyotypes of diploid P. fragilis subsp. villosus (2n = 2x = 14) and tetraploid subsp. secaliformis (2n = 4x = 28) were studied by Giemsa C- and N-banding, and AgNO3 staining and compared with the karyotype of subsp. fragilis (2x). The complements of subsp. villosus and subsp. fragilis were similar, with 8 metacentric and 6 SAT-chromosomes, one metacentric and two submetacentric pairs, with small to minute, polymorphic, heterochromatic satellites. The complement of subsp. secaliformis on the whole agreed with a doubling of the complement of diploid P. fragilis, suggesting autopolyploidy. Only the presence of 12 nucleoli in interphases identified 6 SAT-chromosome pairs. In subsp. villosus one or two extra micronucleoli indicated a chromosome pair with very low nucleolus-forming activity, bringing the number of SAT-chromosome pairs to 4. This number may be a characteristic of Psathyrostachys. Besides very small, inconsistently observed bands, the C-banding pattern consisted of 0-3 small bands ...
http://www.forskningsdatabasen.dk/catalog/9738865
Bacillus fragilis synonyms, Bacillus fragilis antonyms - FreeThesaurus.comBacillus fragilis synonyms, Bacillus fragilis antonyms - FreeThesaurus.com
Synonyms for Bacillus fragilis in Free Thesaurus. Antonyms for Bacillus fragilis. 1 synonym for bacillus: B. What are synonyms for Bacillus fragilis?
http://www.freethesaurus.com/Bacillus+fragilis
Nitrogen metabolizing enzymes from Bacteroides fragilis (2 projects) - SBRUNitrogen metabolizing enzymes from Bacteroides fragilis (2 projects) - SBRU
Our laboratories are particularly well placed to conduct this interdisciplinary study. The PI, Dr Abratt at the University of cape Town, has specialised anaerobic growth facilities available, and a proven track record of research in the areas of anaerobic microbiology and molecular genetics, particularly of the Bacteroides nitrogen metabolism.. In addition, we have established the capability to determine protein structure in Africa for the first time through a grant by the Carnegie Corporation of New York to B.T. Sewell (co-investigator). This grant has enabled the creation of the joint UCT/UWC Masters programme in Structural Biology and has, in particular led to the establishment of a facility for protein X-ray crystallography at the University of the Western Cape and the establishment of a protein NMR facility at the University of Stellenbosch. Six masters students have been recruited to the programme in its first year (2003). Each student cohort will take two years, including a year of ...
http://sbru.salamanderthemes.net/research-projects/nitrogen-metabolizing-enzymes-from-bacteroides-fragilis-2-projects/
Evaluation of peritoneal reinfection after fecal peritonitisEvaluation of peritoneal reinfection after fecal peritonitis
Introduction. Most peritoneal infections are caused by gram-negative and anaerobic bacteria, specially Escherichia coli and Bacteroides fragilis,. Escherichia coli predominates during the acute phase of the process, whereas in the chronic phase, when abscess formation occurs, the predominance is of anaerobic bacteria, mainly Bacteroides fragilis and enterococci, which act synergistically1,2. The association between sepsis and peritonitis has not been fully clarified. During the acute phase, after invasion by gram-negative bacteria, the organism recognizes lipopolysaccharide (LPS) and its major molecule, lipid A, as signals of bacterial penetration. Lipopolysaccharide binding protein (LBP) transfers LPS to CD14 on the surface of monocytes, macrophages and neutrophils3. This phenomenon induces the production and release of mediators, such as tumor necrosis factor α (TNF-α) and interleukins 1, 6 and 8, generating the amplification of the LPS signal in plasma and its transmission to other cells ...
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012000900007&lng=en&nrm=iso&tlng=en
Twenty-eight divergent polysaccharide loci specifying within and amongst strain capsule diversity in three strains of...Twenty-eight divergent polysaccharide loci specifying within and amongst strain capsule diversity in three strains of...
TY - JOUR. T1 - Twenty-eight divergent polysaccharide loci specifying within and amongst strain capsule diversity in three strains of Bacteroides fragilis. AU - Patrick,S.. AU - Blakely,G.W.. AU - Houston,S.. AU - Moore,J.. AU - Abratt,V.R.. AU - dos Santos,Marcelo Bertalan Quintanilha. AU - Cedeño-Tárraga,A.M.. AU - Corton,N.. AU - Corton,C.. AU - Bignell,A.. AU - Barron,A.. AU - Clark,L.. AU - Bentley,S.D.. AU - Parkhill,J.. PY - 2010. Y1 - 2010. N2 - Comparison of the complete genome sequence of Bacteroides fragilis 638R originally isolated in the USA, was made with two previously sequenced strains isolated in the UK (NCTC 9343) and Japan (YCH46). The presence of 10 loci containing genes associated with polysaccharide biosynthesis, each including a putative Wzx flippase and Wzy polymerase, was confirmed in all three strains, despite a lack of cross-reactivity between NCTC 9343 and 638R surface polysaccharide-specific antibodies by immunolabelling and microscopy. Genomic comparisons revealed ...
http://orbit.dtu.dk/en/publications/twentyeight-divergent-polysaccharide-loci-specifying-within-and-amongst-strain-capsule-diversity-in-three-strains-of-bacteroides-fragilis
Plasmid transfer from Escherichia coli to Bacteroides fragilis: differential expression of antibiotic resistance phenotypes |...Plasmid transfer from Escherichia coli to Bacteroides fragilis: differential expression of antibiotic resistance phenotypes |...
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https://www.pnas.org/content/81/22/7203/tab-article-info
BF9343 0029 - Putative beta-galactosidase - Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / JCM 11019 / NCTC 9343) -...BF9343 0029 - Putative beta-galactosidase - Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / JCM 11019 / NCTC 9343) -...
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
http://www.uniprot.org/uniprot/Q5LJ68
Bacteroides fragilis 3 1 12 supercont1.5 genomic scaffold, whole genom - Nucleotide - NCBIBacteroides fragilis 3 1 12 supercont1.5 genomic scaffold, whole genom - Nucleotide - NCBI
Opens the Highlight Feature Bar and highlights feature annotations from the FEATURES table of the record. The Highlight Feature Bar can be used to navigate to and highlight other features and provides links to display the highlighted region separately. Links in the FEATURES table will also highlight the corresponding region of the sequence. More... ...
https://www.ncbi.nlm.nih.gov/nuccore/EQ973217.1
α-Galactosidase 110A from Bacteroides fragilis, Recombinant(EC 3.2.1.-) - Creative Enzymesα-Galactosidase 110A from Bacteroides fragilis, Recombinant(EC 3.2.1.-) - Creative Enzymes
Alpha-galactosidase is a glycoside hydrolase enzyme that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. It is encoded by the GLA ge
https://www.creative-enzymes.com/product/-galactosidase-110a-from-bacteroides-fragilis-recombinant_3607.html
科學人雜誌科學人雜誌
免疫過敏：無菌老鼠一出生就被放入無菌箱中，腸道中沒有半隻腸道菌，這種無菌鼠生活在無菌箱中確實愉快，吃得比一般有菌鼠多，體脂肪反而低，活得又比有菌鼠久，可惜免疫系統不健全，出了無菌箱便無法生存。許多研究都顯示無菌鼠，或以抗生素打亂腸道菌的老鼠，血清中免疫球蛋白IgE濃度顯著高於正常鼠，全身呈現發炎過敏現象；如果給無菌鼠餵食特定的腸道菌，例如脆弱擬桿菌（Bacteroides fragilis），則有助於減輕發炎與過敏現象。許多科學家懷疑，近年來自體免疫疾病發生率快速上升，與抗生素濫用而導致許多人腸道菌嚴重失衡有關 ...
https://sa.ylib.com/MagArticle.aspx?Unit=featurearticles&id=3157
Dynamics of the metallo-beta-lactamase from Bacteroides fragil...Dynamics of the metallo-beta-lactamase from Bacteroides fragil...
Dynamics of the metallo-beta-lactamase from Bacteroides fragilis in the presence and absence of a tight-binding inhibitor.: A significant determinant for the br
https://www.mysciencework.com/publication/show/dynamics-metallo-beta-lactamase-from-bacteroides-fragilis-presence-absence-tight-binding-inhibitor-66e52cff
iAH Search interface 2.4 - Results of the search |page 1|iAH Search interface 2.4 - Results of the search |page 1|
Avila-Campos, Mario Julio et al. Antimicrobial resistance and plasmid detection in strains of the Bacteroides fragilis group. Rev. Inst. Med. trop. S. Paulo, Feb 1993, vol.35, no.1, p.107-110. ISSN 0036- ...
http://www.scielo.br/cgi-bin/wxis.exe/iah/?IsisScript=iah/iah.xis&base=article%5Edlibrary&format=iso.pft&lang=i&nextAction=lnk&indexSearch=AU&exprSearch=CARVALHO,+MARIA+AUXILIADORA+ROQUE+DE
Novel communication between intestinal microbes and developing immune cells in the thymusNovel communication between intestinal microbes and developing immune cells in the thymus
To study the development of these immune cells in the context of gut microbes, researchers monocolonized germ-free mice with a model human commensal, Bacteroides fragilis, and demonstrated that this single species of bacteria could restore the development of PLZF+ innate and innate-like lymphocytes in the thymus of infant mice.. In further proof-of-concept studies, they showed that a mutant B. fragilis lacking expression of Polysaccharide A (PSA) was unable to do the same, suggesting that specific microbial antigens could regulate this early life developmental process.. A similar deficit in these cells was observed in mutant mice that lacked the expression of Toll like receptor 2, a receptor that recognizes bacteria and bacterial components, including B. fragilis PSA, to initiate host protective immune responses.. To understand how this microbial message was delivered to developing thymic cells, Jains group used a novel mouse model to track the migration of cells from the colon to the thymus. ...
https://www.innovations-report.com/html/reports/medicine-health/novel-communication-between-intestinal-microbes-and-developing-immune-cells-in-the-thymus.html
Ontario Ferns - FamiliesOntario Ferns - Families
Another way this website groups species is by Group - species that look alike somehow, but are not necessarily related to each other. In some cases, a Group of species may overlap a Family, in other cases, not ...
http://ontarioferns.com/main/list_family.php
Fragilis抗体(ab15592)| Abcam中国Fragilis抗体(ab15592)| Abcam中国
购买Fragilis兔多克隆抗体(ab15592)，Fragilis抗体经WB,IP验证，可与小鼠,大鼠样本反应。17篇文献引用，2个独立用户反馈。中国现货速达。
http://www.abcam.cn/fragilis-antibody-ab15592.html
Isolation of Metronidazole-Resistant Bacteroides fragilis Carrying the nimA Nitroreductase Gene from a Patient in Washington...Isolation of Metronidazole-Resistant Bacteroides fragilis Carrying the nimA Nitroreductase Gene from a Patient in Washington...
As the appreciation for anaerobic bacteriology has grown, it has become apparent that the isolation of Bacteroides species from clinical isolates is a significant finding. Studies by Redondo et al. (15) and Nguyen et al. (14) have linked Bacteroides bacteremia to higher mortality rates, which can be further affected by the use of inactive antimicrobials in the treatment regimen.. The class of 5-nitroimidazole drugs (metronidazole, tinidizole, and ornidizole) exerts antimicrobial actions via inhibition of DNA synthesis (19). This action requires intracellular reduction of the nitro group of these prodrugs to produce reactive radical species. Although the 5-nitroimidazole drugs were introduced into clinical practice in 1960, resistance of B. fragilis to these drugs was not described until 1978 (10) and remains rare (1, 20-22). The first metronidazole-resistant Bacteroides isolates were found to have altered end products of glucose metabolism that conferred distinctive biochemical and growth ...
https://jcm.asm.org/content/42/9/4127?ijkey=25b1efbdc21f0e2e72b4cf6ed4709a1fa000a478&keytype2=tf_ipsecsha
The design and analysis of unique DNA primer sets and probes to identify and distinguish the bacillus cereus group species:...The design and analysis of unique DNA primer sets and probes to identify and distinguish the bacillus cereus group species:...
Bacillus cereus from the Bacillus cereus group species, which consist of: Bacillus cereus, Bacillus thuringiensis, Bacillus anthracis, Bacillus weihenstephanensis, Bacillus mycoides and Bacillus pseudomycoides is one of the most frequently isolated bacterial foodborne pathogens. Growth of B. cereus results in production of several highly active toxins therefore, consumption of food containing 105-106 bacteria (spores)/g or toxins, is sufficient to cause emetic and diarrhoeal syndromes. The most common source of this bacterium is milk and mixed food products that include milk powder, thus is of particular concern in the baby formula industry. In this study 138 strains of B. cereus group spp. were characterized based on their phenotypic and genotypic features. The study developed unique DNA primers for use in PCR and these were then tested via real-time PCR (RT-PCR): (i) the motB gene encoding the flagellar motor protein MotB was used as a PCR primer target. (ii) New primers and probes, targeting ...
https://ulir.ul.ie/handle/10344/4552
Exploring the Common Gut Bacteria Bacteroides | News & EventsExploring the Common Gut Bacteria Bacteroides | News & Events
Probiotic yogurts and pills promise better health, but the bacteria we ingest find a complex and challenging environment when they enter our gut. Food sources shift with every meal we eat, and the threat of pathogens is ever-present. In this competitive landscape, theres a clear winner already on the field: the genus Bacteroides makes up 30 percent of the bacteria in the human gut, the single most abundant genus.. Bacteroides are a successful bacterium in our gut microbiome. By offering metabolic capabilities that humans dont have, it helps us to obtain important nutrients. So why are Bacteroides so resilient? If we can understand their success, it will ultimately allow us to design probiotic formulations for human health and aid patients with an imbalance of gut bacteria, said Blanca Barquera, an associate professor of biological sciences at Rensselaer Polytechnic Institute and lead researcher on a new project investigating Bacteroides.. With support from a four-year $3 million grant from ...
https://news.rpi.edu/content/2017/11/09/exploring-common-gut-bacteria-bacteroides
Bacteroides salivosus - definition of Bacteroides salivosus by The Free DictionaryBacteroides salivosus - definition of Bacteroides salivosus by The Free Dictionary
Define Bacteroides salivosus. Bacteroides salivosus synonyms, Bacteroides salivosus pronunciation, Bacteroides salivosus translation, English dictionary definition of Bacteroides salivosus. Noun 1. Bacteroides - type genus of Bacteroidaceae; genus of Gram-negative rodlike anaerobic bacteria producing no endospores and no pigment and living in...
http://www.thefreedictionary.com/Bacteroides+salivosus
Construction of a genomic library of the lactose utilising yeast Kluyveromyces marxianus var. fragilis for transformation into...Construction of a genomic library of the lactose utilising yeast Kluyveromyces marxianus var. fragilis for transformation into...
cannot utilise lactose. One possible approach to get around this problem would be to clone the genes responsible for lactose utilisation from a lactose utilising yeast (in this case the genes LAC4 and LAC12 from K.marxianus var.fragilis) into S.cerevisiae. As a preliminary step in the cloning LAC4 and LAC12 into S.cerevisiae a genomic library of an industrial strain of the lactose-utilising yeast, K.marxianus var. fragilis was constructed. Partially Sau3AI digested, size selected fragments of K.marxianus var.fragilis DNA were cloned into the Saccharomyces-Eschericia coli shuttle vector, YEp 13 and the resulting recombinant plasmids were transformed into E.coli DH5α. The resulting library was found to contain approximately 15 000 recombinant plasmid bearing clones with an average insert size of 7.7kb. This library thus contains approximately 116 OOOkb of DNA which is equivalent to approximately 8 times the genome size of K.marxianus var. fragilis. The two genes of interest, LAC4 (which encodes ...
https://researcharchive.lincoln.ac.nz/handle/10182/4813
Acervo Digital: Experimental peritonitis in horses. Hematological and biochemistry aspectsAcervo Digital: Experimental peritonitis in horses. Hematological and biochemistry aspects
Dezesseis eqüinos adultos foram distribuídos aleatoriamente em 4 grupos (GI, GII, GIII e GIV) constituídos por quatro animais, recebendo cada grupo o seguinte inóculo por via intraperitoneal: GI (100 X 10(7) unidades formadoras de colônia (UFC) de Escherichia coli diluídos em 500 ml de solução salina 0,9% estéril); GII (100 X 10(7) UFC de Bacteroides fragilis diluídos em 500 ml de solução salina 0,9% estéril); GIII (100 X 10(7) UFC de Escherichia coli associados a 100 X 10(7) UFC de Bacteroides fragilis diluídos em 500 ml de solução salina 0,9% estéril); GIV (testemunho - 500 ml de solução salina 0,9% estéril). Leucopenia ocorreu em todos os animais inoculados com bactérias, nas primeiras seis horas após as inoculações. Posteriormente a este período, verificou-se em alguns eqüinos inoculados leucocitose. Os eqüinos inoculados com culturas puras de E. coli ou B. fragilis apresentaram peritonites brandas e autolimitantes, enquanto os inoculados com a associação destas ...
https://acervodigital.unesp.br/handle/11449/2947
An anaerobic bacterium, Bacteroides thetaiotaomicron, uses a consortium of enzymes to scavenge hydrogen peroxide<...An anaerobic bacterium, Bacteroides thetaiotaomicron, uses a consortium of enzymes to scavenge hydrogen peroxide<...
TY - JOUR. T1 - An anaerobic bacterium, Bacteroides thetaiotaomicron, uses a consortium of enzymes to scavenge hydrogen peroxide. AU - Mishra, Surabhi. AU - Imlay, James A.. PY - 2013/12. Y1 - 2013/12. N2 - Summary: Obligate anaerobes are periodically exposed to oxygen, and it has been conjectured that on such occasions their low-potential biochemistry will predispose them to rapid ROS formation. We sought to identify scavenging enzymes that might protect the anaerobe Bacteroides thetaiotaomicron from the H2O2 that would be formed. Genetic analysis of eight candidate enzymes revealed that four of these scavenge H2O2in vivo: rubrerythrins 1 and 2, AhpCF, and catalase E. The rubrerythrins served as key peroxidases under anoxic conditions. However, they quickly lost activity upon aeration, and AhpCF and catalase were induced to compensate. The AhpCF is an NADH peroxidase that effectively degraded low micromolar levels of H2O2, while the catalytic cycle of catalase enabled it to quickly degrade ...
https://experts.illinois.edu/en/publications/an-anaerobic-bacterium-bacteroides-thetaiotaomicron-uses-a-consor
Frontiers | The Glycolytic Versatility of Bacteroides uniformis CECT 7771 and Its Genome Response to Oligo and Polysaccharides ...Frontiers | The Glycolytic Versatility of Bacteroides uniformis CECT 7771 and Its Genome Response to Oligo and Polysaccharides ...
Bacteroides spp. are dominant components of the phylum Bacteroidetes in the gut microbiota and prosper in glycan enriched environments. However, knowledge of the machinery of specific species isolated from humans (like Bacteroides uniformis) contributing to the utilization of dietary and endogenous sources of glycans and their byproducts is limited. We have used the cutting-edge nanopore-based technology to sequence the genome of B. uniformis CECT 7771, a human symbiont with a proven pre-clinical efficacy on metabolic and immune dysfunctions in obesity animal models. We have also used massive sequencing approaches to distinguish the genome expression patterns in response to carbon sources of different complexity during growth. At genome-wide level, our analyses globally demonstrate that B. uniformis strains exhibit an expanded glycolytic capability when compared with other Bacteroides species. Moreover, by studying the growth and whole-genome expression of B. uniformis CECT 7771 in response to different
https://www.frontiersin.org/articles/10.3389/fcimb.2017.00383/full
Bacteroides fragilis - Microbiology - Medbullets Step 1Bacteroides fragilis - Microbiology - Medbullets Step 1
M1.MC.15.75) A 36-year-old male suffered a gun-shot wound to the abdomen that required an emergent exploratory laparotomy to repair and resect damaged portions of the bowel. Four days later, the patient reports increased generalized abdominal pain. His vital signs are as follows: T 38.5, HR 110, BP 110/60, RR 18, SpO2 96%. Physical exam reveals extreme tenderness to palpation of the abdomen as well as rebound tenderness, worse in the bilateral lower quadrants. The abdomen is mildly distended with guarding and decreased bowel sounds. The surgical and bullet-entrance wounds appear intact without any evidence of leakage/drainage, erythema, or warmth. Initial lab-work shows an elevated white blood cell count of 17.1 x 10^9 cells/L. A CT scan of the abdomen shows a 4 cm abscess in the left lower quadrant. Which of the following organisms is the most likely cause of this patients current presentation? Tested Concept ...
https://step1.medbullets.com/step1-microbiology/104179/bacteroides-fragilis
The use of parenteral clindamycin in the treatment of obstetric gynecologic patients with severe infections. A comparison of a...The use of parenteral clindamycin in the treatment of obstetric gynecologic patients with severe infections. A comparison of a...
TY - JOUR. T1 - The use of parenteral clindamycin in the treatment of obstetric gynecologic patients with severe infections. A comparison of a clindamycin kanamycin combination with penicillin kanamycin. AU - Ledger, W. J.. AU - Kriewall, T. J.. AU - Sweet, Richard L. AU - Fekety, F. R.. PY - 1974. Y1 - 1974. N2 - Using a system of random selection in patients with severe obstetric gynecologic infections, parenteral penicillin kanamycin was given to 23 women and clindamycin kanamycin was given to 21. Therapeutic response to the two antibiotic regimens was similar; no significant differences were noted in either the posttreatment fever index or the numbers of women requiring other therapy. There was a failure of response to the penicillin kanamycin regimen in those women with Bacteroides fragilis infection and to the clindamycin kanamycin regimen in some of the women with an Enterococcus infection. The implications of these findings for the future selection of antibiotics for patients with severe ...
https://ucdavis.pure.elsevier.com/en/publications/the-use-of-parenteral-clindamycin-in-the-treatment-of-obstetric-g
Bacteroides - Wikipedia, a enciclopedia libreBacteroides - Wikipedia, a enciclopedia libre
Bacteroides é un xénero de bacterias gramnegativas, con forma de bacilo. As especies de Bacteroides non forman esporas, son anaeróbicas, e hai especies móbiles e inmóbiles.[1] A composición de bases do seu ADN ten un contido GC do 40-48%. Bacteroides ten esfingolípidos nas súas membranas, o que é infrecuente nas bacterias. Tamén conteñen ácido meso-diaminopimélico na capa de peptidoglicano da súa parede celular. As especies de Bacteroides son normalmente mutualistas, e constitúen a parte principal da flora intestinal dos mamíferos,[2] onde xogan un papel fundamental no procesamento de moléculas complexas noutras máis simples no intestino do hóspede.[3][4][5] Nas feces humanas informouse dunha cantidade de 1010-1011 células por gramo.[6] Aínda que poden utilizar azucres simples cando dispoñen deles, as principais fontes de enerxía para Bacteroides no intestino son os glicanos (polisacáridos) complexos derivados do hóspede ou de plantas.[7] Certos estudos indican que a ...
https://gl.wikipedia.org/wiki/Bacteroides
Hydrolysis of dietary flavonoid glycosides by strains of intestinal Bacteroides from humans | Biochemical JournalHydrolysis of dietary flavonoid glycosides by strains of intestinal Bacteroides from humans | Biochemical Journal
Rutin and quercitrin are hydrolysed to quercetin, and robinin is hydrolysed to kaempferol, by faecal flora from healthy subjects. The enzymes required for these hydrolyses, namely alpha-rhamnosidase and beta-galactosidase, were produced by some strains of Bacteroides distasonis; other strains, however, synthesized beta-glucosidase. The last-named enzyme was also elaborated by Bacteroides uniformis and Bacteroides ovatus. All the enzymes were produced constitutively. A cell-free extract of B. distasonis containing beta-glucosidase displayed an enzymic activity of 1 mumol/10 min per 10 mg of protein. ...
http://www.biochemj.org/content/248/3/953
Bacteroides - wikidocBacteroides - wikidoc
Bacteroides is a genus of Gram-negative, rod-shaped bacteria. Bacteroides species are non-endospore-forming, anaerobes, and may either be motile or non-motile, depending on the species.[1] The DNA base composition is 40-48% GC. Unusual in bacterial organisms, Bacteroides membranes contain sphingolipids. They also contain meso-diaminopimelic acid in their peptidoglycan layer. Bacteroides are normally commensal, making up the most substantial portion of the mammalian gastrointestinal flora,[2] where they play a fundamental role in processing of complex molecules to simpler ones in the host intestine. As many as 1010-1011 cells per gram of human feces have been reported.[3] They can use simple sugars when available, but the main source of energy is polysaccharides from plant sources. ...
http://es.wikidoc.org/index.php/Bacteroides
Relative abundance of Bacteroides spp. in stools and wastewaters as determined by hierarchical oligonucleotide primer extension...Relative abundance of Bacteroides spp. in stools and wastewaters as determined by hierarchical oligonucleotide primer extension...
A molecular method, termed hierarchical oligonucleotide primer extension (HOPE), was used to determine the relative abundances of predominant Bacteroides spp. present in fecal microbiota and wastewaters. For this analysis, genomic DNA in feces of healthy human adults, bovines, and swine and in wastewaters was extracted and total bacterial 16S rRNA genes were PCR amplified and used as the DNA templates for HOPE. Nineteen oligonucleotide primers were designed to detect 14 Bacteroides spp. at different hierarchical levels (domain, order, cluster, and species) and were arranged into and used in six multiplex HOPE reaction mixtures. Results showed that species like B. vulgatus, B. thetaiotaomicron, B. caccae, B. uniformis, B. fragilis, B. eggerthii, and B. massiliensis could be individually detected in human feces at abundances corresponding to as little as 0.1% of PCR-amplified 16S rRNA genes. Minor species like B. pyogenes, B. salyersiae, and B. nordii were detected only collectively using a primer ...
http://scholarbank.nus.edu.sg/handle/10635/67693
Host-Gut Microbiota Metabolic Interactions | ScienceHost-Gut Microbiota Metabolic Interactions | Science
Humans excrete between 50 to 100 mg of volatile phenols per day, predominantly in the form of 4-cresol and phenol (mainly as glucuronide and sulfate conjugates) with lower amounts of 4-ethylphenol (20). The production of cresols from tyrosine in mammals has been attributed to various species of Clostridium, Bifidobacterium, and Bacteroides fragilis. Other bacteria such as E. coli are associated with phenol production. Altered levels of 4-cresol metabolites in human urine have been associated with diverse physiological and pathological conditions from weight loss to inflammatory bowel disease. These conditions are also associated with altered microbiota composition, namely a reduction in the diversity of the microbiota because of loss of Lactobacillus and Bacteroides species in the case of inflammatory bowel disease (21) and differences in the ratio of the Firmicutes to Bacteroidetes species in the case of weight loss (22).. Dietary fiber (complex carbohydrates) can be digested and subsequently ...
https://science.sciencemag.org/content/336/6086/1262?ijkey=500fa014541e7682527a5f2cbe0f7179a0da3fd7&keytype2=tf_ipsecsha
Bacteroides barnesiae - Biology-Online DictionaryBacteroides barnesiae - Biology-Online Dictionary
Bacteroides barnesiae has a size of 0.5-1.4 micrometer wide and 0.8-10.6 micrometer long that is completely anaerobic and grows at temperature of about 37C which does not require oxygen to survive. It has a cellular fatty acids including C15:0 and iso-C15:0 and in cultured media appears to be circular, raised and grayish-white colonies. Bacteroides barnesiae is predominantly found in gastrointestinal tract of humans as well as in vertebrate animals where bile is present. It gives benefits to the host if this bacterium strictly retained in the gut by hindering pathogenic microorganisms from forming colonies in the intestines. Bacteroides barnesiae play a basic role in the breakdown of polysaccharides a complex molecule into small molecules that is used by the bacterium as well as the host in order to utilize the nitrogenous substances and biotransformation of steroids and bile acids. Scientific classification: ...
https://www.biology-online.org/dictionary/Bacteroides_barnesiae
JCI - Immunologic impact of the intestine in metabolic diseaseJCI - Immunologic impact of the intestine in metabolic disease
Microbiota. The development and function of the intestinal immune system is influenced by the gut microbiota, including bacteria with the capacity to induce specific lineage differentiation in immune cells. Germ-free mice have an underdeveloped intestinal immune system, signifying a role for MAMPs in its establishment (21). Some commensal bacteria such as segmented filamentous bacteria (SFBs) preferentially induce a Th17 response in T cells (22, 23). Other commensals or their products guide an IL-10 Treg response. The capsular polysaccharide-A moiety on Bacteroides fragilis promotes expansion of Foxp3+ Tregs through a TLR2/MyD88 mechanism (24), while Clostridium species can induce Treg formation independent of MyD88, potentially through TGF-β (25). Bacterial metabolites like short-chain fatty acids (SCFA) produced by Akkermansia muciniphila and Faecalibacterium prausnitzii also influence immunity. For instance, butyrate from these organisms increases the differentiation of Tregs in the colon ...
https://www.jci.org/articles/view/88879
Zithromax - Antibiotics :: Canadian PharmacyZithromax - Antibiotics :: Canadian Pharmacy
Zithromax is a semi-synthetic macrolide antibiotic chemically related to erythromycin which is effective against majority of species of gram positive and gram negative microorganisms such as genus Staphylococcus; S. aureus, S. pneumoiane, S. pyogenes, S. agalactiae, Haemophilus influenzae and parainfluenzae, Moraxela catarrhalis, Bacteroides fragilis, Escherichia coli, Bordetella ssp., Borrelia burgdorferi, Haemophilus ducreui, Nisseria gonorrhoeae Ø Chlamidia trachomati. In vitro it showed activity against Legionella pneumophila, Mycoplasma pneumoia Ø hominis, Helicobacter pylori, Toxoplasma gondii, Ureaplasma urealiticum. As a Macrolide antibiotic Zithromax inhibits bacterial protein synthesis and prevents bacteria from growth and propagation. It is used to treat infections of upper and low respiratory organs (tonsillitis, otitis, sinusitis, pneumonia), urogenital infections (urethritis, prostatitis, cervicitis, adnexitis caused by chlamydia, gonorrhea, early syphilis), intestinal ...
https://safepillsnow.com/categories/Antibiotics/Zithromax
Zithromax - Antibiotics :: Sale PharmacyZithromax - Antibiotics :: Sale Pharmacy
Zithromax is a semi-synthetic macrolide antibiotic chemically related to erythromycin which is effective against majority of species of gram positive and gram negative microorganisms such as genus Staphylococcus; S. aureus, S. pneumoiane, S. pyogenes, S. agalactiae, Haemophilus influenzae and parainfluenzae, Moraxela catarrhalis, Bacteroides fragilis, Escherichia coli, Bordetella ssp., Borrelia burgdorferi, Haemophilus ducreui, Nisseria gonorrhoeae Ø Chlamidia trachomati. In vitro it showed activity against Legionella pneumophila, Mycoplasma pneumoia Ø hominis, Helicobacter pylori, Toxoplasma gondii, Ureaplasma urealiticum. As a Macrolide antibiotic Zithromax inhibits bacterial protein synthesis and prevents bacteria from growth and propagation. It is used to treat infections of upper and low respiratory organs (tonsillitis, otitis, sinusitis, pneumonia), urogenital infections (urethritis, prostatitis, cervicitis, adnexitis caused by chlamydia, gonorrhea, early syphilis), intestinal ...
https://fasthealth-online.net/categories/Antibiotics/Zithromax/Zifin
Zithromax - Antibiotics :: Cheapest PharmacyZithromax - Antibiotics :: Cheapest Pharmacy
Zithromax is a semi-synthetic macrolide antibiotic chemically related to erythromycin which is effective against majority of species of gram positive and gram negative microorganisms such as genus Staphylococcus; S. aureus, S. pneumoiane, S. pyogenes, S. agalactiae, Haemophilus influenzae and parainfluenzae, Moraxela catarrhalis, Bacteroides fragilis, Escherichia coli, Bordetella ssp., Borrelia burgdorferi, Haemophilus ducreui, Nisseria gonorrhoeae Ø Chlamidia trachomati. In vitro it showed activity against Legionella pneumophila, Mycoplasma pneumoia Ø hominis, Helicobacter pylori, Toxoplasma gondii, Ureaplasma urealiticum. As a Macrolide antibiotic Zithromax inhibits bacterial protein synthesis and prevents bacteria from growth and propagation. It is used to treat infections of upper and low respiratory organs (tonsillitis, otitis, sinusitis, pneumonia), urogenital infections (urethritis, prostatitis, cervicitis, adnexitis caused by chlamydia, gonorrhea, early syphilis), intestinal ...
https://first-pharm24.com/categories/Antibiotics/Zithromax
Zithromax - Antibiotics :: Sale PharmacyZithromax - Antibiotics :: Sale Pharmacy
Zithromax is a semi-synthetic macrolide antibiotic chemically related to erythromycin which is effective against majority of species of gram positive and gram negative microorganisms such as genus Staphylococcus; S. aureus, S. pneumoiane, S. pyogenes, S. agalactiae, Haemophilus influenzae and parainfluenzae, Moraxela catarrhalis, Bacteroides fragilis, Escherichia coli, Bordetella ssp., Borrelia burgdorferi, Haemophilus ducreui, Nisseria gonorrhoeae Ø Chlamidia trachomati. In vitro it showed activity against Legionella pneumophila, Mycoplasma pneumoia Ø hominis, Helicobacter pylori, Toxoplasma gondii, Ureaplasma urealiticum. As a Macrolide antibiotic Zithromax inhibits bacterial protein synthesis and prevents bacteria from growth and propagation. It is used to treat infections of upper and low respiratory organs (tonsillitis, otitis, sinusitis, pneumonia), urogenital infections (urethritis, prostatitis, cervicitis, adnexitis caused by chlamydia, gonorrhea, early syphilis), intestinal ...
https://fasthealth-online.net/categories/Antibiotics/Zithromax/Nor-zimax
TIGR01201TIGR01201
This HMM describes a set of proteins related to but longer than DNA-binding protein HU. Its distinctive domain architecture compared to HU and related histone-like DNA-binding proteins justifies the designation as superfamily. Members include, so far, one from Bacteroides fragilis, a gut bacterium, and ten from Porphyromonas gingivalis, an oral anaerobe ...
http://www.jcvi.org/cgi-bin/tigrfams/HmmReportPage.cgi?acc=TIGR01201
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Zithromax is a semi-synthetic macrolide antibiotic chemically related to erythromycin which is effective against majority of species of gram positive and gram negative microorganisms such as genus Staphylococcus; S. aureus, S. pneumoiane, S. pyogenes, S. agalactiae, Haemophilus influenzae and parainfluenzae, Moraxela catarrhalis, Bacteroides fragilis, Escherichia coli, Bordetella ssp., Borrelia burgdorferi, Haemophilus ducreui, Nisseria gonorrhoeae Ø Chlamidia trachomati. In vitro it showed activity against Legionella pneumophila, Mycoplasma pneumoia Ø hominis, Helicobacter pylori, Toxoplasma gondii, Ureaplasma urealiticum. As a Macrolide antibiotic Zithromax inhibits bacterial protein synthesis and prevents bacteria from growth and propagation. It is used to treat infections of upper and low respiratory organs (tonsillitis, otitis, sinusitis, pneumonia), urogenital infections (urethritis, prostatitis, cervicitis, adnexitis caused by chlamydia, gonorrhea, early syphilis), intestinal ...
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Zithromax is a semi-synthetic macrolide antibiotic chemically related to erythromycin which is effective against majority of species of gram positive and gram negative microorganisms such as genus Staphylococcus; S. aureus, S. pneumoiane, S. pyogenes, S. agalactiae, Haemophilus influenzae and parainfluenzae, Moraxela catarrhalis, Bacteroides fragilis, Escherichia coli, Bordetella ssp., Borrelia burgdorferi, Haemophilus ducreui, Nisseria gonorrhoeae Ø Chlamidia trachomati. In vitro it showed activity against Legionella pneumophila, Mycoplasma pneumoia Ø hominis, Helicobacter pylori, Toxoplasma gondii, Ureaplasma urealiticum. As a Macrolide antibiotic Zithromax inhibits bacterial protein synthesis and prevents bacteria from growth and propagation. It is used to treat infections of upper and low respiratory organs (tonsillitis, otitis, sinusitis, pneumonia), urogenital infections (urethritis, prostatitis, cervicitis, adnexitis caused by chlamydia, gonorrhea, early syphilis), intestinal ...
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Zithromax is a semi-synthetic macrolide antibiotic chemically related to erythromycin which is effective against majority of species of gram positive and gram negative microorganisms such as genus Staphylococcus; S. aureus, S. pneumoiane, S. pyogenes, S. agalactiae, Haemophilus influenzae and parainfluenzae, Moraxela catarrhalis, Bacteroides fragilis, Escherichia coli, Bordetella ssp., Borrelia burgdorferi, Haemophilus ducreui, Nisseria gonorrhoeae Ø Chlamidia trachomati. In vitro it showed activity against Legionella pneumophila, Mycoplasma pneumoia Ø hominis, Helicobacter pylori, Toxoplasma gondii, Ureaplasma urealiticum. As a Macrolide antibiotic Zithromax inhibits bacterial protein synthesis and prevents bacteria from growth and propagation. It is used to treat infections of upper and low respiratory organs (tonsillitis, otitis, sinusitis, pneumonia), urogenital infections (urethritis, prostatitis, cervicitis, adnexitis caused by chlamydia, gonorrhea, early syphilis), intestinal ...
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Zithromax is a semi-synthetic macrolide antibiotic chemically related to erythromycin which is effective against majority of species of gram positive and gram negative microorganisms such as genus Staphylococcus; S. aureus, S. pneumoiane, S. pyogenes, S. agalactiae, Haemophilus influenzae and parainfluenzae, Moraxela catarrhalis, Bacteroides fragilis, Escherichia coli, Bordetella ssp., Borrelia burgdorferi, Haemophilus ducreui, Nisseria gonorrhoeae Ø Chlamidia trachomati. In vitro it showed activity against Legionella pneumophila, Mycoplasma pneumoia Ø hominis, Helicobacter pylori, Toxoplasma gondii, Ureaplasma urealiticum. As a Macrolide antibiotic Zithromax inhibits bacterial protein synthesis and prevents bacteria from growth and propagation. It is used to treat infections of upper and low respiratory organs (tonsillitis, otitis, sinusitis, pneumonia), urogenital infections (urethritis, prostatitis, cervicitis, adnexitis caused by chlamydia, gonorrhea, early syphilis), intestinal ...
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Cefpodoxime is an oral, third-generation cephalosporin antibiotic. It is active against most Gram-positive and Gram-negative organisms. Notable exceptions include Pseudomonas aeruginosa, Enterococcus, and Bacteroides fragilis. Currently, it is only marketed as generic preparations in the USA, according to the FDA Orange Book. It is commonly used to treat acute otitis media, pharyngitis, sinusitis, and gonorrhea. It also finds use as oral continuation therapy when intravenous cephalosporins (such as ceftriaxone) are no longer necessary for continued treatment.. Zoetis markets cefpodoxime proxetil under the trade name Simplicef for veterinary use. The dose range in dogs is 5-10 mg/kg body weight, administered orally, once a day.. Finecure, India markets the products under trade name Cefpo.. Cefpodoxime inhibits cell wall synthesis by inhibiting the final transpeptidation step of peptidoglycan synthesis in cell walls. It has well established pharmacokinetic profile with absorption of 50%. It is ...
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Asthma is an increasingly common chronic inflammatory airway disorder with phenotypic heterogeneity driven by age, gender, atopy, lung function, lifestyle, body mass indexes, and the underlying cellular and molecular pathways. In asthma, T helper (Th) cells drive inflammatory cascades via cytokine/inflammatory mediators and recruit leukocytes into the airway. While treatments are available, such as inhaled corticosteroids, individuals with severe asthma are often steroid resistant and have a poor quality of life. It is therefore important to develop our understanding of the underlying T cell driven mechanisms leading to pulmonary inflammation such that novel therapies may be developed. Previous work from our lab has demonstrated the importance of commensal microbiota in the development and maintenance of peripheral homeostasis. Exposure to bacterial polysaccharides, such as PSA from Bacteroides fragilis, inhibits Th1 and Th2 activity in murine models by activation of CD4+ FoxP3− CD45Rblo ...
http://www.jimmunol.org/content/198/1_Supplement/220.19
Abstract & Commentary: Streptococcus bovis Group Organisms and the Association with Colon Cancer: Pinning the Tail on the...Abstract & Commentary: Streptococcus bovis Group Organisms and the Association with Colon Cancer: Pinning the Tail on the...
The association between S. bovis group infection (particularly endocarditis) and concurrent colorectal neoplasia has been known for some time.
https://www.reliasmedia.com/articles/132780-abstract-commentary-streptococcus-bovis-group-organisms-and-the-association-with-colon-cancer-pinning-the-tail-on-the-donkey
Stem Group Organism News | SciTechDailyStem Group Organism News | SciTechDaily
While doing geological research in the Namibian desert, scientists believe they uncovered proof of the first animal to have existed on Earth. The sponge-like fossil,…. ...
https://scitechdaily.com/tag/stem-group-organism/
How you were born could shape the rest of your life thanks to the effects of bacteria at birth - Drcelaya.comHow you were born could shape the rest of your life thanks to the effects of bacteria at birth - Drcelaya.com
After several months the gut microbiomes between the two set of infants became more similar with one striking difference - the c-section babies had significantly lower levels of Bacteroides, a strain vital to human health.. Bacteroides are a key strain when it comes to health challenges modern societies face. A number of studies have shown Bacteroides levels are lower in people with obesity. Studies in both mice and humans show that when gut bacteria from thin subjects are transplanted into the colons of obese subjects, most subjects lose weight.. Bacteroides has also been linked with preventing anxiety, and boosting and regulating immunity to prevent inflammatory disorders. This may explain why people who were born via c-section are at increased risk for obesity and asthma.. The study is part of a larger Baby Biome study that is following thousands of newborns through childhood. ...
https://drcelaya.com/2019/10/01/how-you-were-born-could-shape-the-rest-of-your-life-thanks-to-the-effects-of-bacteria-at-birth/
Bacteroides, Bacterial Identification, Bacteria TreatmentBacteroides, Bacterial Identification, Bacteria Treatment
Bacteroides, Bacterial Identification and Bacteria Treatment are considered an interesting alternative to the traditional indicator organisms such as E.coli
https://sourcemolecular.com/human/humanbacteroidetes/
Finding step glk for D-cellobiose catabolism in Pseudomonas fluorescens FW300-N1B4Finding step glk for D-cellobiose catabolism in Pseudomonas fluorescens FW300-N1B4
Comment: Dshi_1655 (A8LLL9) was identified using fitness data, is very important for growth on glucose and several glucose-containing disaccharides; and functional residues seem to be conserved. The related protein PGA1_c05420 (I7DXX1) also seems to be glk. Q5GAN8 = hexA from B. fragilis is a broad-specificity hexokinase (PMID:15659667). Q5GBH5 = rokA = MONOMER-19002 from B. fragilis is a glucose/mannose/NAG kinase (PMID:15659667). (MetaCyc lists it as NAG kinase only but it is just as active on glucose.) CH_123431 is nearly identical to a characterized broad-specificity hexose kinase, so ignore. SCO5059 (Q9ADE8) is reported to have ATP-glucokinase activity (PMID:24200789), so ignore ...
https://papers.genomics.lbl.gov/cgi-bin/gapView.cgi?orgs=orgsFit&set=carbon&orgId=FitnessBrowser__pseudo1_N1B4&path=cellobiose&step=glk
Clavaria fragilis - WikipediaClavaria fragilis - Wikipedia
7.0 7.1 Bisby F.A., Roskov Y.R., Orrell T.M., Nicolson D., Paglinawan L.E., Bailly N., Kirk P.M., Bourgoin T., Baillargeon G., Ouvrard D. (red.) (2011). Species 2000 & ITIS Catalogue of Life: 2011 Annual Checklist.. Species 2000: Reading, UK. Ginkuhà 24 september 2012. ...
https://war.wikipedia.org/wiki/Clavaria_fragilis
Sphaeronectes fragilisSphaeronectes fragilis
Members of the order Siphonophorae include A-form hydroids. Life cycle: The zygote develops into planula inside the gonophore and is later released as an actinula which metamorphoses into polyp stage (Ref. 833). ...
http://sealifebase.ca/summary/Sphaeronectes-fragilis.html
Hibiscus fragilis - WikispeciesHibiscus fragilis - Wikispecies
Text is available under the Creative Commons Attribution-ShareAlike License; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. ...
https://species.wikimedia.org/wiki/Hibiscus_fragilis
Biological classification - Simple English Wikipedia, the free encyclopediaBiological classification - Simple English Wikipedia, the free encyclopedia
Biological classification is how biologists group organisms. The classification has its root in the work of Aristotle who invented a multi-ranked system. A great influence was Carolus Linnaeus, who popularized the idea of binomial nomenclature using a two-part name indicating the genus, and the species. The human species is named Homo sapiens. Names of species are often printed in italics, although there is no obligation to do so (this also goes for names of genera, etc., etc.) Biological classification is also known as taxonomy. It is a science, and like most sciences has evolved over time. At various times different principles were adopted, and it is not rare for different scientists to use different methods. Since the early 20th century, groupings are supposed to fit the Darwinian principle of common descent. These days, molecular evolution studies, which use DNA sequence analysis as data, are popular. This is often called phylogenetics, a branch or form of cladism. This approach creates an ...
https://simple.wikipedia.org/wiki/Biological_classification
이엠생명과학연구원 장내세균 과 체질이엠생명과학연구원 장내세균 과 체질
[좌측부터 체질 1형 2형 3형] 1) 박테로이데스(Bacteroides) : 탄수화물을 분해하고 비타민 B2, B5, C, H를 만드는 것이 주된 기능이다. 박테리오데스 세균이 많은 속에 속하는 피실험자들 중에는 비만을 겪는 사...
http://www.green114.biz/bbs/board09/6863
NanaerobeNanaerobe
Bacteroides fragilis). Like other anaerobes, these organisms do not require oxygen for growth. This growth benefit requires the ...
https://en.wikipedia.org/wiki/Nanaerobe
PeritonitisPeritonitis
Bacteroides fragilis). Fecal peritonitis results from the presence of faeces in the peritoneal cavity. It can result from ...
https://en.wikipedia.org/wiki/Peritonitis
Related changesRelated changes
m Bacteroides fragilis‎; 11:49 . . (+24)‎ . . ‎. مصعب. (talk , contribs)‎ (→‎External links: clean up using AWB) ... m Bacteroides fragilis‎; 16:58 . . (+29)‎ . . ‎. Kku. (talk , contribs)‎ (link antibiotic resistance using Find link) ...
https://en.wikipedia.org/wiki/Special:RecentChangesLinked/Borrelia_parkeri
CefpiromeCefpirome
Bacteroides fragilis, enterococci, Pseudomonas spp. and staphylococci are resistant to cefpirome sulfate, and some Haemophilus ...
https://en.wikipedia.org/wiki/Cefpirome
Phosphonopyruvate decarboxylasePhosphonopyruvate decarboxylase
Zhang G, Dai J, Lu Z, Dunaway-Mariano D (2003). "The phosphonopyruvate decarboxylase from Bacteroides fragilis". J. Biol. Chem ...
https://en.wikipedia.org/wiki/Phosphonopyruvate_decarboxylase
Vaginal floraVaginal flora
Lactobacilli have been shown to inhibit in vitro growth of pathogenic microorganisms, e.g. Bacteroides fragilis, Escherichia ... and Bacteroides spp., Fusobacterium spp., Gardnerella vaginalis, Mobiluncus, Prevotella spp., and Gram-negative enteric ...
https://en.wikipedia.org/wiki/Vaginal_flora
FragilysinFragilysin
Obiso RJ, Lyerly DM, Van Tassell RL, Wilkins TD (October 1995). "Proteolytic activity of the Bacteroides fragilis enterotoxin ... Fragilysin (EC 3.4.24.74, Bacteroides fragilis (entero)toxin) is an enzyme. This enzyme catalyses the following chemical ... Donelli G, Fabbri A, Fiorentini C (January 1996). "Bacteroides fragilis enterotoxin induces cytoskeletal changes and surface ... "The enterotoxin of Bacteroides fragilis is a metalloprotease". Infection and Immunity. 63 (1): 175-81. PMC 172975. PMID 7806355 ...
https://en.wikipedia.org/wiki/Fragilysin
TigecyclineTigecycline
Bacteroides fragilis, Bacteroides thetaiotaomicron, Bacteroides uniformis, Bacteroides vulgatus, Clostridium perfringens, and ... and Bacteroides fragilis. Tigecycline is indicated for treatment of complicated intra-abdominal infections caused by; ...
https://en.wikipedia.org/wiki/Tigecycline
Alpha-galactosidaseAlpha-galactosidase
The current B-zyme used comes from Bacteroides fragilis. The idea of maintaining a blood supply at healthcare facilities with ...
https://en.wikipedia.org/wiki/Alpha-galactosidase
Hereditary spherocytosisHereditary spherocytosis
"Complete nucleotide sequence of insertion element IS4351 from Bacteroides fragilis. - UKPMC Article - UK PubMed Central". UKPMC ...
https://en.wikipedia.org/wiki/Hereditary_spherocytosis
PharmacomicrobiomicsPharmacomicrobiomics
2010). "Bacteroides fragilis RecA protein overexpression causes resistance to metronidazole". Res Microbiol. 161 (5): 346-354. ...
https://en.wikipedia.org/wiki/Pharmacomicrobiomics
7alpha-hydroxysteroid dehydrogenase7alpha-hydroxysteroid dehydrogenase
... and NADP-dependent 7alpha-hydroxysteroid dehydrogenases from bacteroides fragilis". Biochimica et Biophysica Acta (BBA) - ...
https://en.wikipedia.org/wiki/7alpha-hydroxysteroid_dehydrogenase
CefotaximeCefotaxime
As listed, it has modest activity against the anaerobic Bacteroides fragilis. The following represents MIC susceptibility data ... Bacteroides spp. Fusobacterium spp. Notable organisms against which cefotaxime is not active include Pseudomonas and ...
https://en.wikipedia.org/wiki/Cefotaxime
CarbapenemCarbapenem
... s generally exhibit good activity against anaerobes such as Bacteroides fragilis. Like other beta lactam antibiotics ...
https://en.wikipedia.org/wiki/Carbapenem
Host-cell reactivationHost-cell reactivation
Jones DT, Robb FT, Woods DR (December 1980). "Effect of oxygen on Bacteroides fragilis survival after far-ultraviolet ...
https://en.wikipedia.org/wiki/Host-cell_reactivation
Choloylglycine hydrolaseCholoylglycine hydrolase
"Purification and characterization of bile salt hydrolase from Bacteroides fragilis subsp. fragilis". Biochim. Biophys. Acta. ...
https://en.wikipedia.org/wiki/Choloylglycine_hydrolase
List of restriction enzyme cutting sites: Bd-BpList of restriction enzyme cutting sites: Bd-Bp
Reinecke SN, Morgan RD (March 1991). "BfaI, a new MaeI isoschizomer from Bacteroides fragilis, recognizes the sequence 5' C ... Azeddoug H, Reysset G, Sebald M (August 1992). "Characterization of restriction endonuclease BfrBI from Bacteroides fragilis ...
https://en.wikipedia.org/wiki/List_of_restriction_enzyme_cutting_sites:_Bd–Bp
Bacteroidales-1 RNA motifBacteroidales-1 RNA motif
Bayley DP, Rocha ER, Smith CJ (December 2000). "Analysis of cepA and other Bacteroides fragilis genes reveals a unique promoter ...
https://en.wikipedia.org/wiki/Bacteroidales-1_RNA_motif
ImipenemImipenem
Bacteroides fragilis, and Enterococcus faecalis have developed resistance to imipenem to varying degrees. Not many species are ... Acinetobacter anitratus, Acinetobacter calcoaceticus, Actinomyces odontolyticus, Aeromonas hydrophila, Bacteroides distasonis, ... Bacteroides uniformis, and Clostridium perfringens are generally susceptible to imipenem, while Acinetobacter baumannii, some ...
https://en.wikipedia.org/wiki/Imipenem
List of sequenced bacterial genomesList of sequenced bacterial genomes
2004). "Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions regulating cell surface adaptation". PNAS. ... 2005). "Extensive DNA inversions in the B. fragilis genome control variable gene expression" (PDF). Science. 307 (5714): 1463-5 ... 2003). "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis". Science. 299 (5615): 2074-6. Bibcode:2003Sci... ...
https://en.wikipedia.org/wiki/List_of_sequenced_bacterial_genomes
Anaerobic infectionAnaerobic infection
Bacteroides fragilis group is rarely recovered in these infections compared to intra-abdominal infection. Actinomyces spp. and ... Agents no longer recommended are: cefotetan and clindamycin ( Bacteroides fragilis group resistance) and ampicillin-sulbactam ( ... Bacteroides fragilis).Clostridium perfringens can cause of brain abscesses and meningitis following intracranial surgery or ... Anaerobes (mostly B. fragilis group, and rarely C. perfringens) can be recovered in complicated infections associated with ...
https://en.wikipedia.org/wiki/Anaerobic_infection
InfectionInfection
An example of this is Appendicitis, which is caused by Bacteroides fragilis and Escherichia coli. The second is an iatrogenic ...
https://en.wikipedia.org/wiki/Infection
Lipopolysaccharide binding proteinLipopolysaccharide binding protein
Erridge, C; Pridmore, A; Eley, A; Stewart, J; Poxton, IR (2004). "Lipopolysaccharides of Bacteroides fragilis, Chlamydia ...
https://en.wikipedia.org/wiki/Lipopolysaccharide_binding_protein
Glutamine synthetaseGlutamine synthetase
Class III enzymes (GSIII) have, currently, only been found in Bacteroides fragilis and in Butyrivibrio fibrisolvens. It is a ...
https://en.wikipedia.org/wiki/Glutamine_synthetase
TaurolidineTaurolidine
Anaerobes (MIC 0.03-0.3 mg/mL): Bacteroides species (including B. fragilis), Fusobacteria, Clostridium species, ...
https://en.wikipedia.org/wiki/Taurolidine
Tubo-ovarian abscessTubo-ovarian abscess
Bacteroides fragilis, other Bacteroides species, Peptostreptococcus, Peptococcus, and aerobic streptococci. Long term IUD use ...
https://en.wikipedia.org/wiki/Tubo-ovarian_abscess
Bacteroidetes - Vikipeedia, vaba entsüklopeediaBacteroidetes - Vikipeedia, vaba entsüklopeedia
Bacteroides fragilis värvituna Grami järgi. Taksonoomia Riik Bakterid Bacteria. Hõimkond Bacteroidetes. Bacteroidetes on ...
https://et.wikipedia.org/wiki/Bacteroidetes
Fumarate reductase (quinol)Fumarate reductase (quinol)
... and Bacteroides fragilis. Each of these organisms has slightly different gene regulation and function in addition to different ... "Fumarate reductase is a major contributor to the generation of reactive oxygen species in the anaerobe Bacteroides fragilis". ...
https://en.wikipedia.org/wiki/Fumarate_reductase_(quinol)
N-succinylornithine carbamoyltransferaseN-succinylornithine carbamoyltransferase
... and catalytic mechanism of a novel N-succinyl-L-ornithine transcarbamylase in arginine biosynthesis of Bacteroides fragilis". ...
https://en.wikipedia.org/wiki/N-succinylornithine_carbamoyltransferase
ClindamycinClindamycin
... although resistance is increasing in Bacteroides fragilis.[medical citation needed] Most aerobic Gram-negative bacteria (such ... Anaerobic, Gram-negative rod-shaped bacteria, including some Bacteroides, Fusobacterium, and Prevotella, ...
https://en.wikipedia.org/wiki/Clindamycin
Lyme diseaseLyme disease
Bacteroides fragilis. *Tannerella forsythia. *Capnocytophaga canimorsus. *Porphyromonas gingivalis. *Prevotella intermedia. ...
https://en.wikipedia.org/wiki/Lyme_disease
Innate immune systemInnate immune system
Bacteroides species are normally mutualistic bacteria, making up a substantial portion of the mammalian gastrointestinal flora. ... 20] Some species like B. fragilis for example are opportunistic pathogens, causing infections of the peritoneal cavity inhibit ...
https://en.wikipedia.org/wiki/Innate_immune_system
Lemierres syndromeLemierre's syndrome
... which include Bacteroides fragilis and Bacteroides melaninogenicus, Peptostreptococcus spp., Streptococcus microaerophile, ...
https://en.wikipedia.org/wiki/Lemierre's_syndrome
BorreliaBorrelia
Bacteroides fragilis. *Tannerella forsythia. *Capnocytophaga canimorsus. *Porphyromonas gingivalis. *Prevotella intermedia. ...
https://en.wikipedia.org/wiki/Borrelia
Bacteroides, a enciclopedia libreBacteroides, a enciclopedia libre
Unha das especies do xénero máis importantes clinicalmente é Bacteroides fragilis. Bacteroides melaninogenicus foi ... Bacteroides é un xénero de bacterias gramnegativas, con forma de bacilo. As especies de Bacteroides non forman esporas, son ... Non se debe confundir o xénero Bacteroides co tipo morfolóxico de bacterias fixadoras de N (rizobios) chamado bacteroide.. ... "Bacteroides Infection: Overview - eMedicine". Arquivado dende o orixinal o 22 de decembro de 2008. Consultado o 2008-12-11.. ...
https://gl.wikipedia.org/wiki/Bacteroides
Bacteroidetes, a enciclopedia libreBacteroidetes, a enciclopedia libre
Con diferenza, a clase Bacteroidia é a mellor estudada deste filo, e inclúe os xéneros Bacteroides (un organismo abundante nas ... Membros do xénero Bacteroides son patóxenos oportunistas. Os membros das outras dúas clases raramente son patóxenos para os ...
https://gl.wikipedia.org/wiki/Bacteroidetes
Mouth ulcerMouth ulcer
... and Bacteroides species can prolong the ulcerative process. Fungal causes include Coccidioides immitis (valley fever), ... vesicles and bullae which form on the mucous membranes of the oral cavity tend to be fragile and quickly break down to leave ... making the lining more fragile and easily breached.[19]:7 Stomatitis is a general term meaning inflammation within the mouth, ...
https://en.wikipedia.org/wiki/Mouth_ulcer
BacteroidesBacteroides
One of the most important clinically is Bacteroides fragilis. Bacteroides melaninogenicus has recently been reclassified and ... Bacteroides species also benefit their host by excluding potential pathogens from colonizing the gut. Some species (B. fragilis ... Bacteroides is a genus of Gram-negative, obligate anaerobic bacteria. Bacteroides species are non endospore-forming bacilli, ... Bacteroides such as Bacteroides thetaiotaomicron[21] converts these sugars to fermentation products which are beneficial to ...
https://en.wikipedia.org/wiki/Bacteroides
CapnocytophagaCapnocytophaga
Cloning and characterization of the endogenous cephalosporinase gene, cepA, from Bacteroides fragilis reveals a new subgroup of ... CepA (Chromosomal cephalosporinase from Bacteroides fragilis belonging to Ambler class A) is an endogenous cephalosporinase A ... described in Bacteroides fragilis. This beta- lactamase is ubiquitous, but frequently inactive. CepA is encoded by the cepA ... Most beta-lactamases identified in Bacteroides, Prevotella, and Capnocytophaga belong to the Ambler class A. Several beta- ...
https://en.m.wikipedia.org/wiki/Capnocytophaga
CeftolozaneCeftolozane
... and Bacteroides fragilis strains having various resistance phenotypes". Antimicrobial Agents and Chemotherapy. 55 (5): 2390-4. ...
https://en.wikipedia.org/wiki/Ceftolozane
BacteroidetesBacteroidetes
Bacteroides fragilis was the first Bacteroides species isolated in 1898 as a human pathogen linked to appendicitis among other ... Some Bacteroides spp. have a potential to utilize urea as a nitrogen source. Other important functions of Bacteroides spp. ... as non-digestible oligosaccharides in mother milk support the growth of both Bacteroides and Bifidobacterium spp. Bacteroides ... Some Bacteroides spp. and Prevotella spp. can degrade complex plant polysaccharides such as starch, cellulose, xylans, and ...
https://en.wikipedia.org/wiki/Bacteroidetes
List of infectious diseasesList of infectious diseases
Bacteroides fragilis. *Tannerella forsythia. *Capnocytophaga canimorsus. *Porphyromonas gingivalis. *Prevotella intermedia. ...
https://en.wikipedia.org/wiki/List_of_infectious_diseases
List of parasites of humansList of parasites of humans
Dientamoeba fragilis intestines stool up to 10% in industrialized countries ingesting water or food contaminated with feces ...
https://en.wikipedia.org/wiki/List_of_parasites_of_humans
Lipopolysaccharide binding proteinLipopolysaccharide binding protein
Erridge, C; Pridmore, A; Eley, A; Stewart, J; Poxton, IR (2004). "Lipopolysaccharides of Bacteroides fragilis, Chlamydia ...
https://en.wikipedia.org/wiki/Lipopolysaccharide-binding_protein
Imipenem/cilastatinImipenem/cilastatin
Bacteroides fragilis and Peptostreptococcus species. Imipenem/cilastatin was approved for use in the United States in 1985. ...
https://en.wikipedia.org/wiki/Imipenem/cilastatin
PeritonitisPeritonitis
Bacteroides fragilis). Fecal peritonitis results from the presence of faeces in the peritoneal cavity. It can result from ...
https://en.m.wikipedia.org/wiki/Pelvic_peritonitis
Liosta de ghalair thógálacha - VicipéidLiosta de ghalair thógálacha - Vicipéid
Ionfhabhtú Bacteroides. Géineas Bacteroides. Balantidiasis. Balantidium coli. Ionfhabhtú Baylisascaris. Géineas Baylisascaris. ... Dientamoeba fragilis. Diphtheria. Corynebacterium diphtheriae. Diphyllobothriasis. Diphyllobothrium. Dracunculiasis. ...
https://ga.wikipedia.org/wiki/Liosta_de_ghalair_thógálacha
Bacteroides thetaiotaomicronBacteroides thetaiotaomicron
This genomic feature is shared with another member of the genus with a similar lifestyle, Bacteroides fragilis. The genome is ... Bacteroides thetaiotaomicron (formerly Bacillus thetaiotaomicron) is a species of bacterium of the genus Bacteroides. It is a ... behind Bacteroides fragilis. B. thetaiotaomicron is considered commensal or symbiotic. However, it is also an opportunistic ... Bacteroides thetaiotaomicron was first described in 1912 under the name Bacillus thetaiotaomicron and moved to the genus ...
https://en.wikipedia.org/wiki/Bacteroides_thetaiotaomicron
Bacteroides caccaeBacteroides caccae
"Antimicrobial susceptibility of relatively infrequent isolates of the Bacteroides fragilis group: Bacteroides uniformis, ... Bacteroides caccae is a saccharolytic gram-negative bacterium from the genus Bacteroides. They are obligate anaerobes first ... nov., Bacteroides merdae sp. nov., and Bacteroides stercoris sp. nov. Isolated from Human Feces" (PDF). International Journal ... Bacteroides caccae". LPSN.DSMZ.de. "Bacteroides caccae". www.ncbi.nlm.nih.gov. National Center for Biotechnology Information, U ...
https://en.wikipedia.org/wiki/Bacteroides_caccae
SultamicillinSultamicillin
Gynecological infections - Caused by beta-lactamase producing strains of E. coli and Bacteroides sp. (including B. fragilis). ...
https://en.wikipedia.org/wiki/Sultamicillin
CefotetanCefotetan
Escherichia coli: 0.06 µg/mL Bacteroides fragilis: ≤0.06 µg/mL - 512 µg/mL Clostridium perfringens: 1 µg/mL - 4 µg/mL Stork CM ... Notable species include Bacteroides, Streptococcus, and Escherichia. The following represents MIC susceptibility data for a few ...
https://en.wikipedia.org/wiki/Cefotetan
Multidrug-Resistant Bacteroides fragilis - Seattle, Washington, 2013Multidrug-Resistant Bacteroides fragilis - Seattle, Washington, 2013
... The Bacteroides fragilis group consists of species of ... Species identification was confirmed as Bacteroides fragilis ssp. fragilis by biochemical testing, mass spectrometry, and ... Multidrug resistant Bacteroides fragilis recovered from blood and severe leg wounds caused by an improvised explosive device ( ... Bacteroides fragilis are anaerobic bacteria found in the human gastrointestinal tract and often cause intra-abdominal ...
https://www.cdc.gov/mmwr/preview/mmwrhtml/mm6234a2.htm?s_cid=mm6234a2_w
Bacteroides fragilis - WikipediaBacteroides fragilis - Wikipedia
Bacteroides references in Barons Medical Microbiology (online at the NCBI bookshelf). Type strain of Bacteroides fragilis at ... Although the B. fragilis group is the most common species found in clinical specimens, it is the least common Bacteroides ... Bacteroides fragilis is an obligately anaerobic, Gram-negative, rod-shaped bacterium. It is part of the normal microbiota of ... B. fragilis is the most prevalent organism in the B. fragilis group, accounting for 41% to 78% of the isolates of the group. ...
https://en.wikipedia.org/wiki/Bacteroides_fragilis
RCSB PDB - 3P24: Structure of profragilysin-3 from Bacteroides fragilisRCSB PDB - 3P24: Structure of profragilysin-3 from Bacteroides fragilis
Bacteroides fragilis. Mutation(s): 0 Gene Names: bft-3. EC: 3.4.24.74. ... Enterotoxigenic Bacteroides fragilis is the most frequent disease-causing anaerobe in the intestinal tract of humans and ... Enterotoxigenic Bacteroides fragilis is the most frequent disease-causing anaerobe in the intestinal tract of humans and ... Because no similar protein has been found outside enterotoxigenic B. fragilis, our findings support that fragilysins derived ...
https://www.rcsb.org/structure/3P24
Bacteroides fragilis enterotoxin gene sequences in patients with inflammatory bowel diseaseBacteroides fragilis enterotoxin gene sequences in patients with inflammatory bowel disease
We identified enterotoxigenic Bacteroides fragilis in stool specimens of patients with inflammatory bowel disease and other ... Bacteroides fragilis enterotoxin gene sequences in patients with inflammatory bowel disease Emerg Infect Dis. Mar-Apr 2000;6(2 ... We identified enterotoxigenic Bacteroides fragilis in stool specimens of patients with inflammatory bowel disease and other ... none of those with inactive disease had specimens positive for enterotoxigenic Bacteroides fragilis gene sequences. ...
https://pubmed.ncbi.nlm.nih.gov/10756151/?dopt=Abstract
Bacteroides fragilis (Veillon and Zuber) Castellani and Chalmers ATCCBacteroides fragilis (Veillon and Zuber) Castellani and Chalmers ATCC
Bacteroides fragilis ATCC ® 25285™ Designation: VPI 2553 TypeStrain=True Application: Media testing Quality control strain ... Bacteroides fragilis (Veillon and Zuber) Castellani and Chalmers (ATCC® 25285™) Strain Designations: VPI 2553 [EN-2; NCTC 9343] ... Designation of neotype strains for Bacteroides fragilis (Veillon and Zuber) Castellani and Chalmers and Bacteroides ... Bacteroides fragilis (Veillon and Zuber) Castellani and Chalmers (ATCC® 25285D-5™) Add to ...
https://www.atcc.org/en/Products/Cells_and_Microorganisms/Fungi_and_Yeast/Quality_Control_Strains/Pharmaceutical_and_Personal_Care/25285.aspx
Bacteroides fragilis (Veillon and Zuber) Castellani and Chalmers ATCCBacteroides fragilis (Veillon and Zuber) Castellani and Chalmers ATCC
Bacteroides fragilis ATCC ® 25285™ Designation: VPI 2553 TypeStrain=True Application: Media testing Quality control strain ... Bacteroides fragilis (Veillon and Zuber) Castellani and Chalmers (ATCC® 25285™) Click here to learn about our Enhanced ... Quantitative Genomic DNA from Bacteroides fragilis (ATCC® 25285DQ™) Add to frozen Specification range: ≥1 x 105 copies/µL. 100 ... Designation of neotype strains for Bacteroides fragilis (Veillon and Zuber) Castellani and Chalmers and Bacteroides ...
https://www.atcc.org/en/Products/Quality_Control_Strains/By_Identifier/25285.aspx
Bacteroides fragilis 3 1 12 supercont1.5 genomic scaffold, whole genom - Nucleotide - NCBIBacteroides fragilis 3 1 12 supercont1.5 genomic scaffold, whole genom - Nucleotide - NCBI
Bacteroides fragilis 3_1_12 supercont1.5 genomic scaffold, whole genome shotgun ... Bacteroides fragilis 3_1_12 supercont1.5 ... Bacteroides fragilis 3_1_12 supercont1.5 genomic scaffold, whole genome shotgun sequence. GenBank: EQ973217.1 ...
https://www.ncbi.nlm.nih.gov/nuccore/EQ973217.1
Cellular immunity to Bacteroides fragilis capsular polysaccharide. | JEMCellular immunity to Bacteroides fragilis capsular polysaccharide. | JEM
Cellular immunity to Bacteroides fragilis capsular polysaccharide.. M E Shapiro, A B Onderdonk, D L Kasper, R W Finberg ... The polysaccharide capsule of Bacteroides fragilis has been shown to be important in the virulence of the organism. The ... Immunization of C57BL/10J mice with the CP over 5 wk prevents abscess formation when the mice are challenged with B. fragilis ... capsular polysaccharide (CP) of B. fragilis has been extensively purified. Using a murine model of intraabdominal abscess ...
http://jem.rupress.org/content/155/4/1188
Plasmid transfer from Escherichia coli to Bacteroides fragilis: differential expression of antibiotic resistance phenotypes |...Plasmid transfer from Escherichia coli to Bacteroides fragilis: differential expression of antibiotic resistance phenotypes |...
Characterization of the BatI (Bacteroides aerotolerance) operon in Bacteroides fragilis: isolation of a B. fragilis mutant with ... Plasmid transfer from Escherichia coli to Bacteroides fragilis: differential expression of antibiotic resistance phenotypes. D ... The role of BmoR, a MarR Family Regulator, in the survival of Bacteroides fragilis during oxidative stress ... Dps and DpsL Mediate SurvivalIn VitroandIn Vivoduring the Prolonged Oxidative Stress Response in Bacteroides fragilis ...
https://www.pnas.org/content/81/22/7203/tab-article-info
Letter: Antibiotics in bacteroides fragilis infectionsLetter: Antibiotics in bacteroides fragilis infections
Bacteroides fragilis subspecies in clinical isolates. Polk, B. Frank; Kasper, Dennis L.; Polk, B F; Kasper, D L // Annals of ... Bacteroides fragilis group infections in HIV-infected patients. Patey, O.; Breuil, J. // AIDS Patient Care & STDs;Oct97, Vol. ... Details on the bacteroides fragilis group; Reference to studies which were performed in hospitals in France; Results of the ... The Role of Bacteroides fragilis in Pelvic Infections. Osborne, Newton G. // Journal of Gynecologic Surgery;Summer2006, Vol. 22 ...
http://connection.ebscohost.com/c/articles/64111491/letter-antibiotics-bacteroides-fragilis-infections
Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / JCM 11019 / NCTC 9343)Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / JCM 11019 / NCTC 9343)
Bacteroides fragilis NCTC 9343. › Bacteroides fragilis NCTC9343. › Bacteroides fragilis str. NCTC 9343. › Bacteroides fragilis ... Taxonomy - Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / JCM 11019 / NCTC 9343) Basket 0 ... Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / JCM 11019 / NCTC 9343). Taxonomy navigation. › Bacteroides fragilis ...
http://www.uniprot.org/taxonomy/272559
leuS - Leucine--tRNA ligase - Bacteroides fragilis (strain YCH46) - leuS gene & proteinleuS - Leucine--tRNA ligase - Bacteroides fragilis (strain YCH46) - leuS gene & protein
Bacteroides fragilis str. 2-F-2 #4. Bacteroides fragilis CAG:47. Bacteroides fragilis str. 3774 T13. Bacteroides fragilis str. ... Bacteroides fragilis. Bacteroides cellulosilyticus. Bacteroides sp. 2_1_56FAA. Bacteroides fragilis str. S23L17. ... Bacteroides sp. 1_1_6. Bacteroides ovatus. Bacteroides ovatus CL02T12C04. Bacteroides sp. 2_2_4. Bacteroides xylanisolvens XB1A ... Bacteroides ovatus 3_8_47FAA. Bacteroides thetaiotaomicron. Bacteroides sp. 1_1_14. Bacteroides finegoldii DSM 17565. ...
http://www.uniprot.org/uniprot/Q64MG4
KEGG PATHWAY: Cysteine and methionine metabolism - Bacteroides fragilis YCH46KEGG PATHWAY: Cysteine and methionine metabolism - Bacteroides fragilis YCH46
Cysteine and methionine metabolism - Bacteroides fragilis YCH46 [ Pathway menu , Organism menu , Pathway entry , Download KGML ...
https://www.genome.jp/kegg-bin/show_pathway?bfr00270
Bacteroides fragilis subverts mucosal biology: from symbiont to colon carcinogenesis.Bacteroides fragilis subverts mucosal biology: from symbiont to colon carcinogenesis.
The symbiont Bacteroides fragilis constitutes a relatively small proportion (up to 1%-2%) of cultured fecal bacteria, but ... The symbiont Bacteroides fragilis constitutes a relatively small proportion (up to 1%-2%) of cultured fecal bacteria, but ... fragilis toxin (BFT). Strains that do not secrete BFT are nontoxigenic B. fragilis (NTBF), and those that do are called ... There are 2 classes of B. fragilis distinguished by their ability to secrete a zinc-dependent metalloprotease toxin, B. ...
http://www.biomedsearch.com/nih/Bacteroides-fragilis-subverts-mucosal-biology/25105360.html
Bacteroides fragilis endocarditis: a case report and review of literature.Bacteroides fragilis endocarditis: a case report and review of literature.
This article describes a case of Bacteroides fragilis endocarditis associated with portal and superior mesenteric venous ... Endocarditis due to Bacteroides fragilis is a rare disorder. ... Bacteroides fragilis endocarditis: a case report and review of ... Endocarditis due to Bacteroides fragilis is a rare disorder. This article describes a case of Bacteroides fragilis endocarditis ...
http://www.biomedsearch.com/nih/Bacteroides-fragilis-endocarditis-case-report/22358367.html
Deficiency of the ferrous iron transporter FeoAB is linked with metronidazole resistance in Bacteroides fragilis. - PubMed -...Deficiency of the ferrous iron transporter FeoAB is linked with metronidazole resistance in Bacteroides fragilis. - PubMed -...
Deficiency of the ferrous iron transporter FeoAB is linked with metronidazole resistance in Bacteroides fragilis.. Veeranagouda ... Metronidazole is the most commonly used antimicrobial for Bacteroides fragilis infections and is recommended for prophylaxis of ... Deficiency of the ferrous iron transporter FeoAB is linked with metronidazole resistance in Bacteroides fragilis ... Deficiency of the ferrous iron transporter FeoAB is linked with metronidazole resistance in Bacteroides fragilis ...
https://www.ncbi.nlm.nih.gov/pubmed/25028451
Bacteroides fragilis: a case study of bacteremia and septic arthritis. - Free Online LibraryBacteroides fragilis: a case study of bacteremia and septic arthritis. - Free Online Library
Bacteroides fragilis: a case study of bacteremia and septic arthritis.(CLINICAL PRACTICE) by Clinical Laboratory Science; ... CHARACTERISTICS OF Bacteroides fragilis Bacteroides fragilis is an obligate anaerobe which will appear as a gram negative ... Bacteroides fragilis can be cultured with a variety of media. B. fragilis grows towards the bottom of the thioglycollate broth ... APA style: Bacteroides fragilis: a case study of bacteremia and septic arthritis.. (n.d.) >The Free Library. (2014). Retrieved ...
https://www.thefreelibrary.com/Bacteroides+fragilis%3A+a+case+study+of+bacteremia+and+septic+arthritis-a0231094811
Monoclonal antibodies to detect capsular diversity among Bacteroides fragilis isolates. | Journal of Clinical MicrobiologyMonoclonal antibodies to detect capsular diversity among Bacteroides fragilis isolates. | Journal of Clinical Microbiology
Monoclonal antibodies to detect capsular diversity among Bacteroides fragilis isolates.. A Pantosti, R Colangeli, A O Tzianabos ... Monoclonal antibodies to detect capsular diversity among Bacteroides fragilis isolates.. A Pantosti, R Colangeli, A O Tzianabos ... Monoclonal antibodies to detect capsular diversity among Bacteroides fragilis isolates.. A Pantosti, R Colangeli, A O Tzianabos ... Monoclonal antibodies to detect capsular diversity among Bacteroides fragilis isolates. Message Subject (Your Name) has ...
https://jcm.asm.org/content/33/10/2647
Bacteroides fragilis type VI secretion systems use novel effector and immunity proteins to antagonize human gut Bacteroidales...Bacteroides fragilis type VI secretion systems use novel effector and immunity proteins to antagonize human gut Bacteroidales...
Type strains used for in vivo competition include Bacteroides ovatus ATCC 8484, Bacteroides dorei 5_1_36/04, Bacteroides ... Bacteroides caccae CL03T12C61, B. fragilis 2_1_16, and P. copri were antagonized by the 9343 ΔT6SS mutant in a non-T6SS manner ... GA3 loci are not contained on conserved ICE and are confined to Bacteroides fragilis. Unlike GA1 and GA2 T6SS loci, most GA3 ... All four Bacteroides-type strains are sensitive to killing by the T6SS of B. fragilis 638R. ...
https://www.pnas.org/content/early/2016/03/04/1522510113.full
Bacteroides fragilis Supernatant Extracts Enriched in Phenylacetic Acid Induce a Cytotoxic Effect in Mammalian CellsBacteroides fragilis Supernatant Extracts Enriched in Phenylacetic Acid Induce a Cytotoxic Effect in Mammalian Cells
Among Bacteroides species B. fragilis strains are considered to be the opportunistic ones, being the most isolated anaerobic ... The supernatant of the Bacteroides fragilis ATCC 23745 strain was elicited to have the strongest vacuolating effect on Vero ... We believe that the PA is responsible for the pro-apoptotic effect elicited by the supernatant of B. fragilis cultures. ... Cell-free supernatants of 65 B. fragilis strains were assayed and they were capable of inducing vacuolating phenotype on Vero ...
https://www.scirp.org/journal/paperinformation.aspx?paperid=60068
What does bacteroides fragilis mean?What does bacteroides fragilis mean?
Meaning of bacteroides fragilis. What does bacteroides fragilis mean? Information and translations of bacteroides fragilis in ... Definition of bacteroides fragilis in the Definitions.net dictionary. ... Definitions for bacteroides fragilis. Here are all the possible meanings and translations of the word bacteroides fragilis.. ... Bacteroides fragilis. Bacteroides fragilis is a Gram-negative bacillus bacterium species, and an obligate anaerobe of the gut. ...
https://www.definitions.net/definition/bacteroides%20fragilis
The Bacteroides fragilis Pathogenicity Island Is Contained in a Putative Novel Conjugative Transposon | Journal of BacteriologyThe Bacteroides fragilis Pathogenicity Island Is Contained in a Putative Novel Conjugative Transposon | Journal of Bacteriology
Taxonomy of the Bacteroides. I. Deoxyribonucleic acid homologies among Bacteroides fragilis and other saccharolytic Bacteroides ... The genetic element flanking the Bacteroides fragilis pathogenicity island (BfPAI) in enterotoxigenic B. fragilis (ETBF) strain ... The Bacteroides fragilis Pathogenicity Island Is Contained in a Putative Novel Conjugative Transposon. Augusto A. Franco ... The Bacteroides fragilis toxin fragilysin disrupts the paracellular barrier of epithelial cells. Infect. Immun. 65:1431-1439. ...
https://jb.asm.org/content/186/18/6077?ijkey=4f092737b25efaf583300a80283635ecddb95012&keytype2=tf_ipsecsha
Frontiers | CRISPR-Cas Systems in Bacteroides fragilis, an Important Pathobiont in the Human Gut Microbiome | MicrobiologyFrontiers | CRISPR-Cas Systems in Bacteroides fragilis, an Important Pathobiont in the Human Gut Microbiome | Microbiology
Bacteroides make up ~25% of the total gut microbiome. B. fragilis comprises only 2% of the total Bacteroides in the gut, yet ... Bacteroides make up ~25% of the total gut microbiome. B. fragilis comprises only 2% of the total Bacteroides in the gut, yet ... Also, blood isolates of B. fragilis did not have Type IIC CRISPR-Cas systems and had atypical Type IIIB CRISPR-Cas systems that ... Conclusions: This is the first systematic report of CRISPR-Cas systems in a wide range of B. fragilis strains from a variety of ...
https://www.frontiersin.org/articles/10.3389/fmicb.2017.02234/full
AVHANDLINGAR.SE: Identification of Bacteroides fragilis from clinical samplesAVHANDLINGAR.SE: Identification of Bacteroides fragilis from clinical samples
Avhandling: Identification of Bacteroides fragilis from clinical samples. ... A number, of bacterial strains were examined, including B. fragilis, Bacteroides spp. other than B. fragilis and other genera. ... Identification of Bacteroides fragilis from clinical samples. Detta är en avhandling från Stockholm : Karolinska Institutet, ... Sammanfattning: The members of Bacteroides fragilis group are Gram-negative anaerobic, non-spore forming rods that are present ...
https://www.avhandlingar.se/avhandling/366a506195/
Transposon Mutagenesis of Bacteroides fragilis | Springer for Research & DevelopmentTransposon Mutagenesis of Bacteroides fragilis | Springer for Research & Development
Bacteroides fragilisis Gram-negative obligatory anaerobe which usually resides in the gut of humans and animals. As an ... Bacteroides fragilis is Gram-negative obligatory anaerobe which usually resides in the gut of humans and animals. As an ... Transposon mutagenesis Bacteroides fragilis Mariner transposon Mutants This is a preview of subscription content, log in to ... Husain F, Veeranagouda Y, Hsi J et al (2013) Two multidrug-resistant clinical isolates of bacteroides fragilis carry a novel ...
https://rd.springer.com/protocol/10.1007%2F978-1-4939-9570-7_10
RCSB PDB - 2QZU: Crystal structure of the putative sulfatase yidJ from Bacteroides fragilis. Northeast Structural Genomics...RCSB PDB - 2QZU: Crystal structure of the putative sulfatase yidJ from Bacteroides fragilis. Northeast Structural Genomics...
Crystal structure of the putative sulfatase yidJ from Bacteroides fragilis. Northeast Structural Genomics Consortium target ... X-ray crystal structure of the putative sulfatase yidJ from Bacteroides fragilis.. Vorobiev, S.M., Abashidze, M., Seetharaman, ... Crystal structure of the putative sulfatase yidJ from Bacteroides fragilis. Northeast Structural Genomics Consortium target ... Bacteroides fragilis (strain YCH46). Mutation(s): 0 Find proteins for Q64XZ4 (Bacteroides fragilis (strain YCH46)) ...
https://www.rcsb.org/structure/2QZU
Cloning and expression of the Bacteroides fragilis TAL2480 neuraminidase gene, nanH, in Escherichia coli. | Journal of...Cloning and expression of the Bacteroides fragilis TAL2480 neuraminidase gene, nanH, in Escherichia coli. | Journal of...
Cloning and expression of the Bacteroides fragilis TAL2480 neuraminidase gene, nanH, in Escherichia coli.. T A Russo, J S ... We have cloned the Bacteroides fragilis TAL2480 neuraminidase (NANase) structural gene, nanH, in Escherichia coli. This was ... Cloning and expression of the Bacteroides fragilis TAL2480 neuraminidase gene, nanH, in Escherichia coli. ... Cloning and expression of the Bacteroides fragilis TAL2480 neuraminidase gene, nanH, in Escherichia coli. ...
https://jb.asm.org/content/172/5/2594?ijkey=961570891a845b7f133830f87f28bc50bc4967d6&keytype2=tf_ipsecsha
Stat3 activation in murine colitis induced by enterotoxigenic Bacteroides fragilisStat3 activation in murine colitis induced by enterotoxigenic Bacteroides fragilis
This occurs before ETBF-induced mucosal permeability, suggesting that ETBF, likely through B. fragilis toxin and its action on ... Background: Enterotoxigenic Bacteroides fragilis (ETBF), a molecular subclass of the common human commensal, B. fragilis, has ... Stat3 activation in murine colitis induced by enterotoxigenic Bacteroides fragilis Inflamm Bowel Dis. 2014 May;20(5):821-34. ... Methods: C57BL/6 wild-type, C57BL/6, or Rag-1 mice were inoculated with saline, nontoxigenic B. fragilis or ETBF. Histologic ...
https://pubmed.ncbi.nlm.nih.gov/24704822/?dopt=Abstract
Bacteroides fragilis Enterotoxin Gene Sequences in Patients with Inflammatory Bowel Disease - Volume 6, Number 2-April 2000 -...Bacteroides fragilis Enterotoxin Gene Sequences in Patients with Inflammatory Bowel Disease - Volume 6, Number 2-April 2000 -...
... none of those with inactive disease had specimens positive for enterotoxigenic Bacteroides fragilis gene sequences. ... We identified enterotoxigenic Bacteroides fragilis in stool specimens of patients with inflammatory bowel disease and other ... Shetab R, Cohen SH, Prindiville TP, Tang YJ, Cantrell M, Rahmani D, Detection of Bacteroides fragilis enterotoxin gene by PCR. ... Sack RB, Myers LL, Almeido-Hill J, Shoop DS, Bradbury WC, Reid R, Enterotoxigenic Bacteroides fragilis: epidemiologic studies ...
https://wwwnc.cdc.gov/eid/article/6/2/00-0210_article
Prevalence of Fragilysin Gene in Bacteroides fragilis Isolates from Blood and Other Extraintestinal Samples | Journal of...Prevalence of Fragilysin Gene in Bacteroides fragilis Isolates from Blood and Other Extraintestinal Samples | Journal of...
Occurrence of Bacteroides fragilis enterotoxin gene-carrying strains in Germany and the United States. J. Clin. Microbiol. 38: ... Bacteroides fragilis enterotoxin cleaves the zonula adherens protein, E-cadherin. Proc. Natl. Acad. Sci. USA 95:14979-14984. ... Bacteroides fragilis: a possible cause of acute diarrheal disease in newborn lambs. Infect. Immun. 44:241-244. ... Prevalence of Fragilysin Gene in Bacteroides fragilis Isolates from Blood and Other Extraintestinal Samples. Ina Foulon, Denis ...
https://jcm.asm.org/content/41/9/4428
StrainsAbstractSpeciesInfectionsETBFStrainEnterotoxigenic BacteroidesToxinThetaiotaomicronIntestinalGenePolysaccharideEscherichiaATCCCommensal Bacteroides fragilisYCH46NCTCMicrobiologyOrganismVulgatusGenesBacterialSusceptibilityEnterotoxinResistanceBacteriaOxidative Stress ResponseGram-negativeAmong Bacteroides fragilisMultidrug-Resistant BacteroidesClinicalOpportunistic pathogen2019BacteremiaCarbapenemMetronidazoleBacteriophagesVirulence factorSpecimensOrganismsPathogenicAntimicrobial agentsRecombinant2017ClostridiumAntibioticsAbscess formationCfiAProteinsGenusPhages
Strains57
  • B. fragilis strains, especially in the United States, are virtually always susceptible to metronidazole, carbapenems, and beta-lactam antibiotics ( 1 ). (cdc.gov)
  • Although isolated cases of resistance to single agents have been reported, multidrug-resistant (MDR) B. fragilis strains are exceptionally rare ( 1,2 ). (cdc.gov)
  • Reinstatement of species rank for Bacteroides fragilis, B. ovatus, B. distasonis, B. thetaiotaomicron, and B. vulgatus: Designation of neotype strains for Bacteroides fragilis (Veillon and Zuber) Castellani and Chalmers and Bacteroides thetaiotaomicron (Distaso) Castellani and Chalmers. (atcc.org)
  • Strains that do not secrete BFT are nontoxigenic B. fragilis (NTBF), and those that do are called enterotoxigenic B. fragilis (ETBF). (biomedsearch.com)
  • In order to investigate the antigenic diversity of the CPCs of B. fragilis strains, we generated and characterized 10 monoclonal antibodies (MAbs) directed to the CPCs of three reference strains. (asm.org)
  • This complexity and the large number of nonreactive strains indicate that a typing system based on B. fragilis capsular antigens will be difficult to establish. (asm.org)
  • Here, we studied GA3 T6SSs and show that they antagonize most human gut Bacteroidales strains analyzed, except for B. fragilis strains with the same T6SS locus. (pnas.org)
  • Among Bacteroides species B. fragilis strains are considered to be the opportunistic ones, being the most isolated anaerobic bacteria in clinical samples. (scirp.org)
  • Cell-free supernatants of 65 B. fragilis strains were assayed and they were capable of inducing vacuolating phenotype on Vero cells lineage. (scirp.org)
  • If these putative CTns were to be demonstrated to be transmissible, this would suggest that the bft gene can be transferred from ETBF to nontoxigenic B. fragilis strains by a mechanism similar to that for the spread of antibiotic resistance genes. (asm.org)
  • The only recognized virulence factor of these strains is a toxin termed B. fragilis toxin, or BFT. (asm.org)
  • Many strains of Bacteroides species carry large self-transmissible elements called conjugative transposons (CTns). (asm.org)
  • Clustered regularly interspaced short palindromic repeats (CRISPR) elements in all strains of B. fragilis ( n = 109) with publically available genomes were identified. (frontiersin.org)
  • This is the first systematic report of CRISPR-Cas systems in a wide range of B. fragilis strains from a variety of sources. (frontiersin.org)
  • Recent investigations have revealed that some strains of B. fragilis may also be associated with diarrheal disease in animals and humans due to the production of an enterotoxin. (avhandlingar.se)
  • Almost 98% of the B. fragilis strains were positive in co-agglutination. (avhandlingar.se)
  • Among the 283 non-B. fragilis strains only two showed false positive reaction. (avhandlingar.se)
  • Treatment of B. fragilis infections caused emergence of multidrug-resistant strains. (springer.com)
  • Rashidan M, Azimirad M, Alebouyeh M et al (2018) Detection of B. fragilis group and diversity of bft enterotoxin and antibiotic resistance markers cepA, cfiA and nim among intestinal Bacteroides fragilis strains in patients with inflammatory bowel disease. (springer.com)
  • Some strains of B. fragilis associated with diarrhea in young farm animals ( 7 , 8 ) and humans ( 9 ) produce an extracellular enterotoxin also known as fragilysin. (asm.org)
  • In this study, we examined 103 B. fragilis strains isolated from blood and 63 strains isolated from other extraintestinal sites for the presence of the gene encoding fragilysin. (asm.org)
  • Metronidazole was found to be active against Bacteroides fragilis strains isolated from human lesions. (bmj.com)
  • The proteolytic activity of selected Bacteroides fragilis strains was evaluated by zymography and, after gastrointestinal digestion of gliadin, by high-pressure liquid chromatography/electrospray ionization/tandem mass spectrometry. (asm.org)
  • The effects of B. fragilis strains on Caco-2 cell culture permeability and inflammatory response to digested gliadin were determined. (asm.org)
  • B. fragilis strains, representing the isolated clones and carrying metalloprotease genes, showed gelatinase activity and exerted the strongest adverse effects on the integrity of the Caco-2 cell monolayer. (asm.org)
  • All B. fragilis strains also showed gliadin-hydrolyzing activity, and some of them generated immunogenic peptides that preserved or increased inflammatory cytokine production (tumor necrosis factor alpha) and showed increased ability to permeate through Caco-2 cell cultures. (asm.org)
  • These findings suggest that increased abundance of B. fragilis strains with metalloprotease activities could play a role in CD pathogenesis, although further in vivo studies are required to support this hypothesis. (asm.org)
  • Agar spot assays of eight B. fragilis strains in overlays, showing zones of growth inhibition (dark spots) by secreted molecule(s) from wild-type strain 638R and 638RΔ1646 (BSAP-1 deletion mutant) and by purified, His-tagged BSAP-1. (asm.org)
  • A) Agar spot assays showing results for two transposon mutants of 638RΔ1646 that lost inhibitory activity against four B. fragilis strains. (asm.org)
  • B) Agar spot assays displaying the sensitivity/resistance profiles of four B. fragilis strains exposed to B. fragilis CM11 with an empty vector or ubb in trans . (asm.org)
  • A) Gene maps of three representative B. fragilis strains showing the three predominant genetic types in the ubb or corresponding regions. (asm.org)
  • B. fragilis strains each have a similar mutL (orange), and the DNA between each of the three genetic types begins to diverge 39 bp downstream from this gene. (asm.org)
  • Ability of B. fragilis 638R, 638RΔ1646 mutant, and proteins to inhibit the growth of B. fragilis strains. (asm.org)
  • The nanH structural gene for neuraminidase was cloned from B. fragilis TM4000 and was used to create two isogenic strains with chromosomal disruptions at the nanH gene. (asm.org)
  • Metronidazole administered in standard or pulse dosing fashion was highly active against both susceptible and resistant strains of Bacteroides spp. (asm.org)
  • abstract = "Comparison of the complete genome sequence of Bacteroides fragilis 638R originally isolated in the USA, was made with two previously sequenced strains isolated in the UK (NCTC 9343) and Japan (YCH46). (dtu.dk)
  • Enterotoxigenic Bacteroides fragilis (ETBF) strains, which produce a 20- kDa zinc metalloprotease toxin (BFT), have been associated with diarrheal disease in animals and young children. (elsevier.com)
  • Clindamycin-resistant strains of B. fragilis were isolated from two patients with bacteremia at two institutions. (elsevier.com)
  • The pathogenicity of 42 strains of Bacteroides of human origin was estimated by intracutaneous injection of bacterial suspensions into guinea-pig skin. (microbiologyresearch.org)
  • Comparisons of living and heat-killed suspensions revealed that B. fragilis strains maintained themselves and possibly multiplied in the skin, whereas the lesions induced by non-fra-gilis strains appeared to be due mainly to toxicity. (microbiologyresearch.org)
  • Measurement of skin pathogenicity in terms of the number of viable organisms in the inoculum that produced a lesion 10 mm in diameter showed that B. fragilis was, on average, 17 times as pathogenic as non-fragilis strains. (microbiologyresearch.org)
  • Bacteriophages of the Bacteroides fragilis strains HSP40 and RYC2056 are used as indicators of human-specific and general (non-host specific) fecal pollution in water bodies. (tci-thaijo.org)
  • To overcome this limitation, in this study, we developed a DNA-based method to simultaneously detect representative bacteriophages (B40-8 and B56-3) that infect B. fragilis strains HSP40 and RYC2056, respectively. (tci-thaijo.org)
  • Therefore, cocultures of Bifidobacterium and Bacteroides can behave differently against fermentable carbohydrates as a function of the specific characteristics of the strains from each species. (cfsremission.com)
  • Non-toxigenic B. fragilis (NTBF) strains are symbiotic in the intestinal environment, providing protection from inflammatory disease while Enterotoxigenic B. fragilis (ETBF) strains induce colitis through a toxin called B. fragilis toxin (BFT). (uchicago.edu)
  • We find that toxigenic strains of B. fragilis transcriptionally regulate production of BFT in response to environmental and growth conditions, partially mediated by a two-component system response regulator. (uchicago.edu)
  • The investigation was performed with 9 strains of B. fragilis isolated from pregnant women in their 38th week of pregnancy, strain IPLE 323 obtained from France, strains BE17 and BE61 obtained from Netherlands and a strain 210 isolated from a case of appendicitis. (mysciencework.com)
  • This study was conducted in a hospital setting to determine whether enterotoxigenic strains of Bacteroides fragilis (ETBF) were associated with childhood diarrhoea. (bvsalud.org)
  • 1280 strains of anaerobic bacteria from the B.fragilis group were studied. (buyantibiotics24h.net)
  • Among the strains studied, B.fragilis (65%), B.thetaiotaomicron (16%) and B.vulgatus (8% ) predominant other representatives of this group of anaerobic bacteria were much less common. (buyantibiotics24h.net)
  • During the past decade, strains of B. fragilis that produce an enterotoxin have been implicated as the cause of diarrhea in a number of animals, including humans. (vt.edu)
  • Specific pathogen-free (SPF) C57BL/6J or germfree 129S6/SvEv mice were orally inoculated with wild-type ETBF (WT-ETBF) strains, a nontoxigenic WT strain of B. fragilis (WT-NTBF), WT-NTBF overexpressing bft (rETBF), or WT-NTBF overexpressing a biologically inactive mutated bft (rNTBF). (elsevier.com)
  • Some Bifidobacterium strains produce exopolysaccharides (EPS), complex carbohydrate polymers that promote changes in the metabolism of B. fragilis when this microorganism grows in their presence. (beds.ac.uk)
  • To demonstrate that B. fragilis can use EPS from bifidobacteria as fermentable substrates, purified EPS fractions from two strains, Bifidobacterium longum E44 and Bifidobacterium animalis subsp. (beds.ac.uk)
  • Strains of B. fragilis were inhibited by 4--greater than 128 micrograms benzylpenicillin or cephalothin/ml, 1.0--64 micrograms cefoxitin/ml, 0.064--2 micrograms clindamycin or metronidazole/ml, 2--8 micrograms chloramphenicol/ml, 2--16 micrograms fusidic acid/ml and 0.032--32 micrograms doxycycline/ml. (meta.org)
  • The ability of human sera depleted of immunoglobulin or of components of complement to promote the phagocytosis and intracellular killing of the two strains of Bacteroides by human leukocytes was measured in vitro under anaerobic conditions. (meta.org)
  • Neither hypogammaglobulinemic sera nor pooled normal human serum that was heated at 56 C for 30 min supported phagocytosis and killing of the two strains of Bacteroides. (meta.org)
Abstract2
  • CHARACTERIZATION AND MOLECULAR ANALYSIS OF FRAGILYSIN: THE BACTEROIDES FRAGILIS TOXIN by Richard Joseph Obiso, Jr. Dr. Tracy D. Wilkins, chairman Department of Biochemistry and Anaerobic Microbiology (ABSTRACT) Bacteroides fragilis is a gram negative, anaerobic rod, that is a member of the normal colonic microflora of most mammals, and it is the anaerobe most commonly isolated from human soft tissue infections. (vt.edu)
  • abstract = "An indirect enzyme-linked immunosorbent assay was developed to detect specific Bacteroides fragilis antigen(s) in human urine. (elsevier.com)
Species24
  • The Bacteroides fragilis group consists of species of obligate anaerobic bacteria that inhabit the human gut. (cdc.gov)
  • Although the B. fragilis group is the most common species found in clinical specimens, it is the least common Bacteroides present in fecal microbiota, comprising only 0.5% of the bacteria present in stool. (wikipedia.org)
  • In vitro activity of ten antibiotics, including tigecycline, against Bacteroides species in Austria. (ebscohost.com)
  • Bacteroides species comprise about 30% of the bacterial population in the lower intestine (1). (thefreelibrary.com)
  • Bacteroides species are considered commensal organisms because they benefit their hosts in numerous ways, such as assisting in the digestion of complex carbohydrates and development of the immune system, as well as contributing to the biotransformation of bile salts and vitamin synthesis. (thefreelibrary.com)
  • However, like many indigenous microflora, Bacteroides species can become an opportunistic pathogen once released into sterile areas. (thefreelibrary.com)
  • Here we show that the abundant gut species Bacteroides fragilis produce T6SSs that deploy previously undescribed toxins able to antagonize numerous species of human gut Bacteroidales. (pnas.org)
  • Because the genes encoding effector and immunity proteins are contained in two variable regions of GA3 loci, GA3 T6SSs of the species B. fragilis are likely the source of numerous novel effector and immunity proteins. (pnas.org)
  • Bacteroides species are nearly half of the fecal flora community and some are host symbionts crucial to host nutrition and systemic immunity. (scirp.org)
  • Bacteroides fragilis is a Gram-negative bacillus bacterium species, and an obligate anaerobe of the gut. (definitions.net)
  • The B. fragilis group is the species of Bacteroidaceae isolated with greatest frequency in clinical specimens. (definitions.net)
  • These putative CTns, designated CTn86 and CTn9343 for ETBF 86-5443-2-2 and NCTC 9343, respectively, differ from previously described Bacteroides species CTns in a number of ways. (asm.org)
  • While CRISPR-Cas systems have been identified in bacteria from a wide variety of ecological niches, there are no studies to describe CRISPR-Cas elements in Bacteroides species, the most prevalent anaerobic bacteria in the lower intestinal tract. (frontiersin.org)
  • The dominating species in the colon microflora are B. thetaiotaomicron, B. vulgatus and B. distasonis, while B. fragilis constitutes only 0.5% of the cultivable colon microflora. (avhandlingar.se)
  • B. fragilis species account for roughly one-foutth of all anaerobic bacteria isolated from clinical specimen. (avhandlingar.se)
  • Therefore, an early and rapid identification of B. fragilis is an important factor for the treatment of diseases caused by B. fragilis species. (avhandlingar.se)
  • Compared with other Gram-negative bacteria, B. fragilis species grow slower and with some difficulty The limitations of the above-mentioned assays are that they are time consuming and cumbersome. (avhandlingar.se)
  • The results showed that mAb C3 has a high specificity and can be used in coagglutination for rapid identification of the B. fragilis species. (avhandlingar.se)
  • Of all species, B. fragilis causes most human Bacteroides infections. (hopkinsguides.com)
  • polydextrose ingestion …species (B. fragilis , B. vulgatus, and B. intermedius) decreased, whereas LACTOBACILLUS: and BIFIDOBACTERIUM: species increased. (cfsremission.com)
  • Bacteroides fragilis is the most frequent species at the human intestinal mucosal surface, it contributes to the maturation of the immune system although is also considered as an opportunistic pathogen. (beds.ac.uk)
  • The commonly isolated species was B. fragilis (73.7%), followed by Bacteroides thetaiotaomicron (8.8%), Bacteroides vulgatus (8.8%), and others. (elsevier.com)
  • The results of a multicenter US survey using the National Committee for Clinical Laboratory Standards currently recommended methodology for measuring in vitro susceptibility of 2673 isolates of Bacteroides fragilis group species were compared from 1997 to 2000. (oup.com)
  • In general the resistance rates of the non-fragilis B. fragilis group species were higher than those of B. fragilis for all the drugs tested. (bvsalud.org)
Infections20
  • The B. fragilis group is the most commonly isolated Bacteroidaceae in anaerobic infections, especially those that originate from the gastrointestinal microbiota. (wikipedia.org)
  • B. fragilis is involved in 90% of anaerobic peritoneal infections. (wikipedia.org)
  • Bacteroides infections at eMedicine Brook I (June 2010). (wikipedia.org)
  • The Role of Bacteroides fragilis in Pelvic Infections. (ebscohost.com)
  • Discusses the role of Bacteroides fragilis in the development of pelvic infections. (ebscohost.com)
  • Background: Bacteroides fragilis are among the most important anaerobic bacteria behind most of the anaerobic infections. (ebscohost.com)
  • Bacteroides fragilis group infections in HIV-infected patients. (ebscohost.com)
  • Bacteriodes fragilis, which is one particular type of the bacteria, is commonly found in abdominal wound infections and in the blood when the intestines are diseased. (ebscohost.com)
  • Metronidazole is the most commonly used antimicrobial for Bacteroides fragilis infections and is recommended for prophylaxis of colorectal surgery. (nih.gov)
  • In fact, B. fragilis is the most commonly isolated organism in anaerobic infections (1). (thefreelibrary.com)
  • 70% of Bacteroides infections. (frontiersin.org)
  • Therefore, B. fragilis is regarded as the most important anaerobic pathogen causing intra-abdominal abscesses and bloodstream infections. (avhandlingar.se)
  • B. fragilis is also infamous for causing serious infections. (springer.com)
  • The drug is not toxic and side effects are rare and it would therefore seem highly suitable for treating Bacteroides infections and also may be considered prophylactically in certain situations that are described. (bmj.com)
  • The Gram-negative Bacteroides fragilis is the most frequently isolated bacterium from anaerobic infections. (uncg.edu)
  • The susceptibility of Bacteroides fragilis to the administration of clindamycin, and the efficacy of this agent in Bacteroides infections are well documented. (elsevier.com)
  • Clinically significant resistance to clindamycin therapy has not been noted previously in B. fragilis infections. (elsevier.com)
  • Bacteroides fragilis is an opportunistic pathogen which can cause life threatening infections in humans and animals. (nrf.ac.za)
  • Fragilysin is a recently discovered virulence factor that could contribute to the pathogenesis of B. fragilis in both intestinal and soft tissue infections. (vt.edu)
  • Consequently B. fragilis is the clinical isolate most frequently found in systemic infections, this microorganism being then considered as an opportunistic pathogen [ 7 ]. (beds.ac.uk)
ETBF10
  • The genetic element flanking the Bacteroides fragilis pathogenicity island (BfPAI) in enterotoxigenic B. fragilis (ETBF) strain 86-5443-2-2 and a related genetic element in NCTC 9343 were characterized. (asm.org)
  • The enterotoxin of enterotoxigenic B. fragilis (ETBF) could induce fluid changes in ligated intestinal segments and cytotoxic response in HT29/C1 cells. (avhandlingar.se)
  • In this study, an IMS-PCR assay, based on the use of B. fragilis mAbs, followed by PCR amplification of the enterotoxin gene for a rapid, specific and sensitive detection of ETBF directly from clinical samples has been developed. (avhandlingar.se)
  • Enterotoxigenic Bacteroides fragilis (ETBF), a molecular subclass of the common human commensal, B. fragilis, has been associated with inflammatory bowel disease. (nih.gov)
  • C57BL/6 wild-type, C57BL/6, or Rag-1 mice were inoculated with saline, nontoxigenic B. fragilis or ETBF. (nih.gov)
  • This occurs before ETBF-induced mucosal permeability, suggesting that ETBF, likely through B. fragilis toxin and its action on the colonic epithelial cell, triggers mucosal immune cell Stat3 activation. (nih.gov)
  • Enterotoxigenic B. fragilis (ETBF) is an emerging enteric pathogen associated with diarrheal diseases in children, adults, and animals ( 4 , 7 - 9 ). (cdc.gov)
  • Enterotoxigenic Bacteroides fragilis (ETBF) causes diarrhea and is implicated in inflammatory bowel diseases and colorectal cancer. (elsevier.com)
  • The only known ETBF virulence factor is the Bacteroides fragilis toxin (BFT), which induces E-cadherin cleavage, interleukin-8 secretion, and epithelial cell proliferation. (elsevier.com)
  • Enterotoxigenic Bacteroides fragilis (ETBF) produces the Bacteroides fragilis toxin, which has been associated with acute diarrheal disease, inflammatory bowel disease, and colorectal cancer (CRC). (sparrho.com)
Strain17
  • In May 2013, an MDR B. fragilis strain was isolated from the bloodstream and intra-abdominal abscesses of a patient who had recently received health care in India. (cdc.gov)
  • Our data support that GA3 T6SSs likely allow the producing B. fragilis strain to create a protected niche in the human colon. (pnas.org)
  • The supernatant of the Bacteroides fragilis ATCC 23745 strain was elicited to have the strongest vacuolating effect on Vero cells monolayers and peritoneal macrophages. (scirp.org)
  • In B. fragilis, NANase production from the two plasmids was inducible by free N-acetylneuraminic acid or sialic acid-containing substrates, just as in the parental TAL2480 strain. (asm.org)
  • D) Agar spot assay showing sensitivity of B. fragilis strain 0878320-1 to BfUbb versus purified bovine ubiquitin. (asm.org)
  • C) Agar spot assay of the BfUbb peptide overlaid with sensitive strain B. fragilis 078320-1 containing an empty vector or the vector overexpressing the antitoxin-encoding gene higA . (asm.org)
  • A local B. fragilis host strain, SP25 (DSM29413), was isolated from a pooled swine feces sample taken from a non-antibiotic farm. (iwaponline.com)
  • The reference B. fragilis strain, RYC2056, could detect phages in swine samples but also detected phages in most human sewage and polluted urban canal samples. (iwaponline.com)
  • B. fragilis strain SP25 exhibited relatively high resistance to most of the veterinary antimicrobial agents tested. (iwaponline.com)
  • The catalase gene was cloned by screening a B. fragilis library for complementation of catalase activity in an Escherichia coli catalase mutant (katE katG) strain. (ecu.edu)
  • The cloned gene, designated katB, encoded a catalase enzyme with electrophoretic mobility identical to that of the purified protein from the B. fragilis parental strain. (ecu.edu)
  •  This awareness can help to ensure prompt implementation of proper infection control measures and to get patients onto the right antibiotics as soon as possible. An American patient who was recently hospitalized overseas and then returned to the United States was found to have an infection with a multi-drug resistant strain of the bacteria Bacteroides fragilis . (cdc.gov)
  • RESULTS: We sequenced Bacteroides fragilis strain BE1 using both the Illumina MiSeq and Oxford Nanopore MinION platforms. (ed.ac.uk)
  • CONCLUSIONS: The single chromosome assembly of Bacteroides fragilis strain BE1 was achieved using only modest amounts of data, publicly available software and commodity computing hardware. (ed.ac.uk)
  • The Oxford Nanopore MinION device is a revolutionary mobile sequencer that can produce thousands of long, single molecule reads.RESULTS: We sequenced Bacteroides fragilis strain BE1 using both the Illumina MiSeq and Oxford Nanopore MinION platforms. (ed.ac.uk)
  • We identified gene rearrangements and the state of invertible promoters in the strain.CONCLUSIONS: The single chromosome assembly of Bacteroides fragilis strain BE1 was achieved using only modest amounts of data, publicly available software and commodity computing hardware. (ed.ac.uk)
  • Goat hyperimmune γ-globulin to B. fragilis strain ATCC 23745 was added and incubated, and supernatants were tested for antibody activity to polysaccharide-protein antigen of the same organism. (elsevier.com)
Enterotoxigenic Bacteroides7
  • Enterotoxigenic Bacteroides fragilis is the most frequent disease-causing anaerobe in the intestinal tract of humans and livestock and its specific virulence factor is fragilysin, also known as B. fragilis toxin. (rcsb.org)
  • We identified enterotoxigenic Bacteroides fragilis in stool specimens of patients with inflammatory bowel disease and other gastrointestinal disorders. (nih.gov)
  • none of those with inactive disease had specimens positive for enterotoxigenic Bacteroides fragilis gene sequences. (nih.gov)
  • Sears, C.L. (2009) Enterotoxigenic Bacteroides Fragilis: A Rogue among Symbiotes. (scirp.org)
  • Effect of the oral intake of yogurt containing Bifidobacterium longum BB536 on the cell numbers of enterotoxigenic Bacteroides fragilis in microbiota. (cfsremission.com)
  • Association of enterotoxigenic Bacteroides fragilis with childhood diarrhoea. (bvsalud.org)
  • Exfoliating colitis associated with enterotoxigenic Bacteroides fragilis in a piglet. (elsevier.com)
Toxin2
  • There are 2 classes of B. fragilis distinguished by their ability to secrete a zinc-dependent metalloprotease toxin, B. fragilis toxin (BFT). (biomedsearch.com)
  • The Bacteroides fragilis toxin gene is prevalent in the colon mucosa of colorectal cancer patients. (sparrho.com)
Thetaiotaomicron2
  • Furthermore, regimens against one B. fragilis isolate and one B. thetaiotaomicron isolate corresponding to one-fourth and one-eighth of the thrice-daily and pulse dosing regimens, mimicking peak metronidazole concentrations achieved in abscesses, were simulated in 48-h experiments (metronidazole MIC = 1 mg/liter). (asm.org)
  • Studies were conducted to determine the requirements for immunoglobulin and complement in opsonization of Bacteroides fragilis and Bacteroides thetaiotaomicron. (meta.org)
Intestinal5
  • Bacteroides fragilis is an obligatory anaerobic microorganism found in the normal intestinal flora of humans. (asm.org)
  • Proteolytic activity of the Bacteroides fragilis enterotoxin causes fluid secretion and intestinal damage in vivo. (asm.org)
  • Bacteroides fragilis may prevent intestinal inflammatory disease as this bacteria produces Polysaccharide A (PSA), which suppresses the inflammatory response of the immune system (by suppressing IL-17 production). (aurametrix.com)
  • Bacteroides fragilis is a ubiquitous anaerobic bacterium in the mammalian intestinal tract. (uchicago.edu)
  • Bacteroides fragilis, a component of the normal intestinal flora, is an obligate anaerobe capable of long-term survival in the presence of air. (ecu.edu)
Gene22
  • Because no similar protein has been found outside enterotoxigenic B. fragilis, our findings support that fragilysins derived from a mammalian adamalysin/ADAM xenolog that was co-opted by B. fragilis through a rare case of horizontal gene transfer from a eukaryotic cell to a bacterial cell. (rcsb.org)
  • AF280705 Bacteroides fragilis isolate ATCC 25285 RecA (recA) gene, partial cds. (atcc.org)
  • U05887 Bacteroides fragilis ATCC 25285 beta-lactamase (cepA-85) gene, complete cds. (atcc.org)
  • AF280642 Bacteroides fragilis isolate ATCC 25285 glutamine synthetase (glnA) gene, partial cds. (atcc.org)
  • It has been reported that the bft gene is contained in a 6-kb pathogenicity island termed the B. fragilis pathogenicity island, or BfPAI ( 9 , 20 ). (asm.org)
  • Understanding CRISPR/Cas function in B. fragilis will elucidate their role in gene expression, DNA repair and ability to survive exposure to antibiotics. (frontiersin.org)
  • Husain F, Veeranagouda Y, Hsi J et al (2013) Two multidrug-resistant clinical isolates of bacteroides fragilis carry a novel metronidazole resistance nim gene (nimJ). (springer.com)
  • Cloning and expression of the Bacteroides fragilis TAL2480 neuraminidase gene, nanH, in Escherichia coli. (asm.org)
  • We have cloned the Bacteroides fragilis TAL2480 neuraminidase (NANase) structural gene, nanH, in Escherichia coli. (asm.org)
  • By using deletion analysis and Tn1000 mutagenesis, the NANase structural gene and control region that functions in B. fragilis were localized to a 1.5- to 2.0-kb region of the insert. (asm.org)
  • Of 166 Bacteroides fragilis isolates, 26.2% of 103 isolates from blood and 20.6% of 63 extraintestinal isolates harbored the fragilysin gene (difference not statistically significant). (asm.org)
  • The B. fragilis 638R gene map (top) shows that ubb is contained in a genetic region likely acquired with three other small genes. (asm.org)
  • The B. fragilis 3_1_12 gene map (middle) shows that a few B. fragilis genomes have no genes inserted in this region. (asm.org)
  • The B. fragilis 078320-1 gene map (bottom) shows the most predominant B. fragilis genetic type, where higBA genes are present in the divergent region along with an additional copy of the 52-bp element downstream from mutL . (asm.org)
  • Identification of B. fragilis and ubb , higA , higB , and BF638R_1646 ( bsap1 ) in human gut metagenomes comprising subset 3CGC of the integrated gene catalog (IGC). (asm.org)
  • The major determinant of carbapenem resistance in Bacteroides fragilis is production of CfiA metallo-beta-lactamase via activation of the cfiA gene by IS elements (higher level resistance) or by activation of its putative own promoter. (diva-portal.org)
  • B. fragilis VRC404 contains an insertion flanked by disrupted copies of the nanH gene, and B. fragilis VRC426 contains a deletion of a significant portion of nanH coding sequences. (asm.org)
  • The frequency of resistance to carbapenems in Bacteroides fragilis isolates is rising and is conferred by a metallo-β-lactamase encoded by the cfiA gene. (microbiologyresearch.org)
  • Functionality of the protein was confirmed by targeted insertional mutagenesis of the cbp1 gene in B. fragilis GSH18 which resulted in the specific loss of both the ,31 kDa and the ,34 kDa adhesin bands. (nrf.ac.za)
  • Purified his-tagged Cbp1, expressed in a B. fragilis wild-type and a glycosylation deficient mutant, confirmed that the cbp1 gene encoded the observed collagen adhesin, and showed that the 34 kDa band represents a glycosylated version of the ,31 kDa protein. (nrf.ac.za)
  • This study is the first to report the presence of collagen type I adhesin proteins in B. fragilis and to functionally identify a gene encoding a collagen binding protein. (nrf.ac.za)
  • The objective of this study was to characterize B. fragilis isolates from various clinical specimens, to analyze their susceptibility profile toward most common anti-anaerobic antimicrobials, and to study the frequency of nim gene determining resistance to nitroimidazoles. (elsevier.com)
Polysaccharide8
  • Cellular immunity to Bacteroides fragilis capsular polysaccharide. (rupress.org)
  • The polysaccharide capsule of Bacteroides fragilis has been shown to be important in the virulence of the organism. (rupress.org)
  • The capsular polysaccharide (CP) of B. fragilis has been extensively purified. (rupress.org)
  • Using a murine model of intraabdominal abscess formation, we have been able to demonstrate cellular immunity to the capsular polysaccharide of B. fragilis. (rupress.org)
  • The capsular polysaccharide complex (CPC) of Bacteroides fragilis is composed of two distinct polysaccharides, designated PS A and PS B, and is a major virulence factor of this microorganism. (asm.org)
  • Bacteroides fragilis polysaccharide A as the archetypical symbiosis factor. (springer.com)
  • The gut commensal Bacteroides fragilis or its capsular polysaccharide A (PSA) can prevent various peripheral and CNS sterile inflammatory disorders. (caltech.edu)
  • A polysaccharide from the human commensal Bacteroides fragilis protects against CNS demyelinating disease. (msdiscovery.org)
Escherichia3
  • Yet, despite sharing a similar LβH structure with LpxAs from Escherichia coli and others, previously unseen calcium ions are observed on the threefold axis in B. fragilis LpxA to help stabilize the trimeric assembly. (escholarship.org)
  • The B. fragilis nrdA and nrdB genes were overexpressed in Escherichia coli, and CDP reductase assays confirmed that they encoded an active enzyme. (ecu.edu)
  • In this study, we examined the enzymatic properties of the 60-kDa sialidase NanH1 of B. fragilis YCH46, which was prepared as a recombinant protein (rNanH1) in Escherichia coli. (kagawa-u.ac.jp)
ATCC2
  • X83935 B.fragilis 16S rRNA (ATCC 25285T). (atcc.org)
  • The combination of Bacteroides fragilis ATCC 25285, Clostridium difficile ATCC 700057 and Fusobacterium necrophorum ATCC 25286 produce odor associated with flatulence. (aurametrix.com)
Commensal Bacteroides fragilis1
  • The human gut commensal Bacteroides fragilis produces sialidases that remove a terminal sialic acid from host-derived polysaccharides. (kagawa-u.ac.jp)
YCH461
  • The collagen binding proteins isolated by both these independent methods were subjected to tandem mass spectroscopy for peptide identification and matched to a single hypothetical protein encoded by B. fragilis NCTC 9343 (BF0586), conserved in YCH46 (BF0662) and 638R (BF0633) and which is designated in this study as cbp1 (collagen binding protein). (nrf.ac.za)
NCTC1
  • Ligand-free and UDP-GlcNAc-bound crystal structures of LpxA from Bacteroides fragilis NCTC 9343, the most common pathogenic bacteria found in abdominal abscesses, have been determined and are presented here. (escholarship.org)
Microbiology2
  • Bacteroides references in Baron's Medical Microbiology (online at the NCBI bookshelf). (wikipedia.org)
  • The June issue of Clinical Microbiology and Infectious Diseases published the results of a study on the antibiotic resistance of anaerobic bacteria of the group Bacteroides fragilis , isolated in Europe , conducted under the supervision of world-renowned Swedish microbiologist Karl-Erica Nord (C.-E. Nord). (buyantibiotics24h.net)
Organism4
  • B. fragilis is the most prevalent organism in the B. fragilis group, accounting for 41% to 78% of the isolates of the group. (wikipedia.org)
  • This organism was formerly classified as subspecies of B. fragilis. (definitions.net)
  • Two American Type Culture Collection Bacteroides fragilis isolates (metronidazole MIC for each organism = 1 mg/liter) were exposed to metronidazole for 48 or 96 h. (asm.org)
  • Studies on nitrogen assimilation in B. fragilis are fundamental to the understanding of how this organism exists within the gastrointestinal environment and how it out-competes the majority of other gut organisms in becoming the most successful opportunistic pathogen if it breaches the mucosal barrier. (salamanderthemes.net)
Vulgatus1
  • Bacteroides distasonis shows the highest resistance rates among β-lactam antibiotics, whereas Bacteroides vulgatus shows the highest resistance levels among fluoroquinolones. (oup.com)
Genes9
  • Interestingly, there are also reports of certain genes for metabolic enzymes on B. fragilis that are actually stimulated by oxygen exposure. (thefreelibrary.com)
  • Also, blood isolates of B. fragilis did not have Type IIC CRISPR-Cas systems and had atypical Type IIIB CRISPR-Cas systems that were lacking adjacent cas genes. (frontiersin.org)
  • There are four apparent CRISPR-Cas systems in B. fragilis -three systems have adjacent cas genes. (frontiersin.org)
  • Veeranagouda Y, Husain F, Tenorio EL, Wexler HM (2014) Identification of genes required for the survival of B. fragilis using massive parallel sequencing of a saturated transposon mutant library. (springer.com)
  • Bacteroides clones ( n = 274) were isolated, identified, and screened for the presence of the virulence genes ( bft and mpII ) coding for metalloproteases. (asm.org)
  • B. fragilis clones carrying virulence genes coding for metalloproteases were more abundant in CD patients than in controls. (asm.org)
  • B. fragilis contains an extensive catalog of six trx genes and analyses indicated each is differentially regulated during oxidative conditions. (uncg.edu)
  • We observed a marked activation of the inflammatory response by Real-time PCR and ELISA in coinfected cells compared to B. henselae-infected cells (63 vs 23 up-regulated genes), and after EPCs infection with mutant B. fragilis ΔPSA (≅90% up-regulated genes) compared to B. fragilis. (unicampania.it)
  • nim genes were present in 4 (11.4%) B. fragilis isolates (n = 35). (elsevier.com)
Bacterial4
  • A modified Immuno Polymerase Chain Reaction (mIPCR) using mAb 4H8 for identification of B. fragilis from bacterial colony as well as from clinical samples (pus), with the detection limit of 104 CFU/mL bacterial suspension has been developed. (avhandlingar.se)
  • Bacteroides fragilis , a gram-negative rod, constitutes 1% to 2% of the normal colonic bacterial microflora in humans ( 1 , 2 ). (cdc.gov)
  • The bacterial numbers of the Bacteroides - Prevotella group or the Bacteroides fragilis group in CD patients have been demonstrated to be increased compared to those in healthy controls ( 8 , 26 ). (asm.org)
  • A role for Bacteroides fragilis neuraminidase in bacterial growth in two model systems. (asm.org)
Susceptibility5
  • Antibiotic susceptibility profiles of European Bacteroides fragilis with reduced carbapenem susceptibility. (ebscohost.com)
  • The article discusses the results of a study on the susceptibility profiles of European Bacteroides fragilis to antibiotic. (ebscohost.com)
  • IMSEAR at SEARO: Susceptibility to current antimicrobial agents of Bacteroides fragilis. (who.int)
  • Dhamabutra N, Sripayak B, Chongthalung A, Vichivanives P. Susceptibility to current antimicrobial agents of Bacteroides fragilis. (who.int)
  • Agar dilution technique susceptibility test of isolated Bacteroides fragilis from the normal healthy women's and infected gynecological patients' cervical areas were studied with current antimicrobial agents. (who.int)
Enterotoxin2
  • The pathogenicity of B. fragilis is related to its production of a potent enterotoxin, a zinc-containing metalloprotease with a molecular weight of 20,000 (10) . (cdc.gov)
  • Clinical characteristics and evolution were comparable in patients with B. fragilis bacteremia with or without this enterotoxin. (asm.org)
Resistance11
  • Production of beta lactamase appears to be the main mechanism of antibiotic resistance in B. fragilis. (wikipedia.org)
  • Clindamycin is no longer recommended as the first-line agent for B. fragilis due to emerging high-level resistance (>30% in some reports). (wikipedia.org)
  • The article focuses on the regional trend of antibiotic resistance of clinically significant isolates of the Bacteroides fragilis group in South-East Austria to ten anti-anaerobic antibiotics. (ebscohost.com)
  • Deficiency of the ferrous iron transporter FeoAB is linked with metronidazole resistance in Bacteroides fragilis. (nih.gov)
  • A transposon mutant library was generated in B. fragilis 638R (BF638R) to identify the genetic loci associated with resistance to metronidazole. (nih.gov)
  • Veeranagouda Y, Husain F, Boente R et al (2014) Deficiency of the ferrous iron transporter FeoAB is linked with metronidazole resistance in Bacteroides fragilis . (springer.com)
  • This study reconfirmed the correlation between ISs and carbapenem resistance in B. fragilis. (elsevier.com)
  • Aims of our study were (i) to determine the prevalence of B. fragilis division II (cfiA positive) isolates among blood stream and non-blood stream isolates from two major Slovenian tertiary-care hospitals and (ii) to assess its influence on phenotypic resistance to imipenem. (elsevier.com)
  • Conclusions: Resistance to the most commonly used empirical anti-anaerobic drugs including Mtz was noted in the isolates of B. fragilis group. (elsevier.com)
  • B. fragilis shows the lowest resistance rates for all antibiotics. (oup.com)
  • Antimicrobial resistance patterns of 913 clinical isolates of Bacteroides fragilis group organisms were monitored during an 8-year period in Korea . (bvsalud.org)
Bacteria8
  • http://prod.hopkins-abxguide.org/pathogens/bacteria/anaerobic_gram-neg._bacilli/bacteroides_fragilis.html?contentInstanceId=255919[permanent dead link] Levinson, W. (2010). (wikipedia.org)
  • The symbiont Bacteroides fragilis constitutes a relatively small proportion (up to 1%-2%) of cultured fecal bacteria, but colonizes most humans. (biomedsearch.com)
  • Coculture stimulated the growth of B. longum, retarding that of B. fragilis , with concomitant changes in the production of some proteins and metabolites of both bacteria. (cfsremission.com)
  • Comparing the data with the results of a similar study carried out in 1992, the sensitivity of bacteria of the B.fragilis group to anti-anaerobic drugs in Europe decreased. (buyantibiotics24h.net)
  • Therefore, there is an urgent need to continue multicenter studies of the sensitivity of anaerobic bacteria, in particular representatives of the B.fragilis group. (buyantibiotics24h.net)
  • This report demonstrates that B. fragilis can consume some EPS from bifidobacteria, with a concomitant release of SCFA and organic acids, suggesting a role for these biopolymers in bacteria-bacteria cross-talk within the intestine. (beds.ac.uk)
  • fragilis bacteria cultured in blood agar medium for 48 hours. (publicdomainfiles.com)
  • It was shown that recent Swedish clinical isolates of anaerobic bacteria are susceptible to many antibiotics by the agar dilution method with the exception of the Bacteroides group versus beta-lactam antibiotics or tetracyclines. (meta.org)
Oxidative Stress Response1
  • Studies have attributed the aerotolerance and oxidative stress response of B. fragilis to enzymes which detoxify and protect the bacterium from oxygen radicals. (thefreelibrary.com)
Gram-negative5
  • Bacteroides fragilis is an obligately anaerobic, Gram-negative, rod-shaped bacterium. (wikipedia.org)
  • Bacteroides fragilis is an obligate anaerobe which will appear as a gram negative bacillus on a gram stain. (thefreelibrary.com)
  • The members of Bacteroides fragilis group are Gram-negative anaerobic, non-spore forming rods that are present in the normal flora of human intestine. (avhandlingar.se)
  • Bacteroides fragilis is Gram-negative obligatory anaerobe which usually resides in the gut of humans and animals. (springer.com)
  • Bacteroides fragilis is a gram-negative anaerobe belonging to the gut microflora. (unicampania.it)
Among Bacteroides fragilis1
  • Monoclonal antibodies to detect capsular diversity among Bacteroides fragilis isolates. (asm.org)
Multidrug-Resistant Bacteroides1
  • During hospitalisation the patient suffered from bacteraemia with a multidrug-resistant Bacteroides fragilis isolate. (sdu.dk)
Clinical10
  • Bacteroides fragilis subspecies in clinical isolates. (ebscohost.com)
  • Selection for feoAB mutations as a result of metronidazole treatment will disable the pathogenic potential of B. fragilis and could contribute to the clinical efficacy of metronidazole. (nih.gov)
  • Using these two monoclonal antibodies alone or in combination with PCR assay, three different assays for identification of B. fragilis from clinical samples have been set up. (avhandlingar.se)
  • The mIPCR assay was also successful in order to detect B. fragilis from clinical pus samples. (avhandlingar.se)
  • These results indicated that mIPCR assay with mAb 4H8 has a high specificity and high sensitivity, and mIPCR may be used to detect B. fragilis in pus samples or other type of clinical sample. (avhandlingar.se)
  • A new diagnostic kit, which contains a polyvalent antiserum for either Bacteroides fragilis or Bacteroides melaninogenicus, was tested for reliability and specificity on 146 clinical samples of different origin. (bmj.com)
  • The test gives a semiquantitative idea of the number of bacteroides organisms present in the clinical specimens even in the presence of a mixed flora. (bmj.com)
  • Here we reported the only female case with her specific clinical and management course and summarized all reported cases of mycotic aneurysm caused by Bacteroides fragilis to clarify their conditions and treatments, alert the difficulty in diagnosis, and importance of highly suspicious. (biomedcentral.com)
  • Of 276 nonduplicate Bacteroides fragilis clinical isolates recovered from 1997 to 2004, 3 were resistant to carbapenem. (elsevier.com)
  • Introduction: Members of Bacteroides fragilis group are the most frequently isolated anaerobic pathogens in the clinical laboratory from diverse infection sites. (elsevier.com)
Opportunistic pathogen2
  • Bacteroides fragilis is an opportunistic pathogen, occurring normally in the human digestive tract, but causing severe and often life-threatening abscess formation and sepsis outside of this environment. (salamanderthemes.net)
  • Bacteroides fragilis is an anaerobic opportunistic pathogen, occurring normally in the human digestive tract, but causing abscess formation and sepsis outside of this environment. (salamanderthemes.net)
20193
  • Veeranagouda Y., Husain F., Wexler H.M. (2019) Transposon Mutagenesis of Bacteroides fragilis . (springer.com)
  • 2019. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540052/2/Bacteroides_fragilis. (hopkinsguides.com)
  • Smalley, Darren and Rocha, Edson R. and Smith, C. Jeffrey, "Aerobic-Type Ribonucleotide Reductase in the Anaerobe Bacteroides fragilis," Journal of Bacteriology 184, no. 4 (February 2002), http://hdl.handle.net/10342/3425 (accessed March 19, 2019). (ecu.edu)
Bacteremia1
  • Bacteroides fragilis: a case study of bacteremia and septic arthritis. (thefreelibrary.com)
Carbapenem1
  • Insertion sequence (IS) elements were found only in the 3 carbapenem-resistant B. fragilis isolates, which produced metallo-β-lactamase at a level detectable by UV spectrophotometry. (elsevier.com)
Metronidazole4
  • In general, B. fragilis is susceptible to metronidazole, carbapenems, tigecycline, beta-lactam/beta-lactamase inhibitor combinations (e.g. ampicillin/sulbactam, piperacillin/tazobactam), and certain antimicrobials of the cephalosporin class, including cefoxitin. (wikipedia.org)
  • Metronidazole Metronidazole active against most B. fragilis . (vetstream.com)
  • Emergence of metronidazole-resistant Bacteroides fragilis, India. (cdc.gov)
  • This study compares standard thrice-daily dosing and pulse dosing of metronidazole against Bacteroides spp. (asm.org)
Bacteriophages4
  • B. fragilis bacteriophages are commonly used as tracers of human faecal material. (wikipedia.org)
  • We assessed the occurrence and specificity of bacteriophages of Bacteroides fragilis in swine farms for their potential application in microbial source tracking. (iwaponline.com)
  • Thus, the newly developed PCR assay demonstrated potential for the environmental monitoring of Bacteroides bacteriophages, decreasing the analysis time to a few hours. (tci-thaijo.org)
  • These bacteriophages include somatic coliphages and Bacteroides fragilis phages. (univ-lorraine.fr)
Virulence factor1
  • Fragilysin seems not to be an important virulence factor in B. fragilis disease. (asm.org)
Specimens1
  • Consecutive non-duplicate B. fragilis isolates from blood stream and non-blood stream specimens were included in the analysis from 2015 to 2017 period. (elsevier.com)
Organisms3
  • The G+C contents of the BfPAI (35%) and the flanking DNA (47 to 50%) differ greatly from that reported for the B. fragilis chromosome (43%) ( http://www.sanger.ac.uk/Projects/B_fragilis ), suggesting that the BfPAI and its flanking region are two distinct genetic elements originating from different organisms. (asm.org)
  • The G+C content of the BfPAI (35%) and the flanking DNA (47 to 50%) differ greatly from that reported for the B. fragilis chromosome (42%), suggesting that the BfPAI and its flanking region are two distinct genetic elements originating from very different organisms. (elsevier.com)
  • Skin tests of pathogens may be of value in the analysis of virulence factors of Bacteroides and possibly of other anaerobic organisms. (microbiologyresearch.org)
Pathogenic2
  • Molecular biology tools such as transposon mutagenesis help to decipher and understand commensal and pathogenic faces of B. fragilis . (springer.com)
  • How are glutamate dehydrogenase and glutamine synthetase activities in B. fragilis regulated under the various nitrogen conditions found within the gut and during pathogenic tissue invasion, and what role does the protein structure of these enzymes play in this regulation? (salamanderthemes.net)
Antimicrobial agents1
  • In addition, the majority of B. fragilis isolates are resistant to ß-lactam antimicrobial agents as well as other antibiotics. (avhandlingar.se)
Recombinant3
  • α-Galactosidase 110A from Bacteroides fragilis, Recombinant(EC 3.2.1. (creative-enzymes.com)
  • However, the biochemical properties of recombinant B. fragilis sialidase expressed in a heterologous host remain uncharacterized. (kagawa-u.ac.jp)
  • The results and methods described in this study will be useful for preparing and characterizing recombinant proteins for other B. fragilis sialidase isoenzymes. (kagawa-u.ac.jp)
20171
  • 2017. Gut symbiont Bacteroides fragilis secretes a eukaryotic-like ubiquitin protein that mediates intraspecies antagonism. (asm.org)
Clostridium1
  • It states that polymicrobials Clostridium perfringens, Bacteroides. (ebscohost.com)
Antibiotics1
  • 2003]" - stopped the drop of b.fragilis seen with taking antibiotics. (cfsremission.com)
Abscess formation1
  • Immunization of C57BL/10J mice with the CP over 5 wk prevents abscess formation when the mice are challenged with B. fragilis intraperitoneally. (rupress.org)
CfiA1
  • Bacteroides fragilis can be classified into division I (cfiA negative) and division II (cfiA positive) isolates. (elsevier.com)
Proteins1
  • rNanH1 preferentially hydrolyzed the sialyl α2,8 linkage and cleaved sialic acids from mucin and serum proteins (e.g., fetuin and transferrin) but not from α1-acid glycoprotein, which is similar to the previously observed biochemical properties for a native sialidase purified from B. fragilis SBT3182. (kagawa-u.ac.jp)
Genus1
  • Microbes of the genus Bacteroides make up ~25% of the total gut microbiome. (frontiersin.org)
Phages3
  • The assay did not produce false positive results for the Bacteroides phages PG76, HB13, and GA17 or for the enterococcal phages AIM06 and SR14. (tci-thaijo.org)
  • The aims of this study were to determine the occurrence and concentrations of somatic coliphages and Bacteroides fragilis phages in the stools of a human population residing in eastern France (n=193). (univ-lorraine.fr)
  • Somatic coliphages were detected in 68% of the stools at a mean concentration of 4.3×103 PFU⋅g−1 and Bacteroides fragilis phages were detected in 11% of the stools at a mean concentration of 7×101 PFU⋅g−1. (univ-lorraine.fr)
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