Bacteroidaceae: A family of gram-negative bacteria found primarily in the intestinal tracts and mucous membranes of warm-blooded animals. Its organisms are sometimes pathogenic.Fusobacterium: A genus of gram-negative, anaerobic, rod-shaped bacteria found in cavities of humans and other animals. No endospores are formed. Some species are pathogenic and occur in various purulent or gangrenous infections.Bacteroidaceae Infections: Infections with bacteria of the family BACTEROIDACEAE.Bacteroides: A genus of gram-negative, anaerobic, rod-shaped bacteria. Its organisms are normal inhabitants of the oral, respiratory, intestinal, and urogenital cavities of humans, animals, and insects. Some species may be pathogenic.Uterus: The hollow thick-walled muscular organ in the female PELVIS. It consists of the fundus (the body) which is the site of EMBRYO IMPLANTATION and FETAL DEVELOPMENT. Beyond the isthmus at the perineal end of fundus, is CERVIX UTERI (the neck) opening into VAGINA. Beyond the isthmi at the upper abdominal end of fundus, are the FALLOPIAN TUBES.Mullerian Ducts: A pair of ducts near the WOLFFIAN DUCTS in a developing embryo. In the male embryo, they degenerate with the appearance of testicular ANTI-MULLERIAN HORMONE. In the absence of anti-mullerian hormone, mullerian ducts give rise to the female reproductive tract, including the OVIDUCTS; UTERUS; CERVIX; and VAGINA.Urogenital Abnormalities: Congenital structural abnormalities of the UROGENITAL SYSTEM in either the male or the female.Septum Pellucidum: A triangular double membrane separating the anterior horns of the LATERAL VENTRICLES of the brain. It is situated in the median plane and bounded by the CORPUS CALLOSUM and the body and columns of the FORNIX (BRAIN).Uterine Diseases: Pathological processes involving any part of the UTERUS.Hysteroscopy: Endoscopic examination, therapy or surgery of the interior of the uterus.Hysterosalpingography: Radiography of the uterus and fallopian tubes after the injection of a contrast medium.Gastroscopes: Endoscopes used for examining the interior of the stomach.BulgariaPortraits as Topic: Graphic representations, especially of the face, of real persons, usually posed, living or dead. (From Thesaurus for Graphic Materials II, p540, 1995)Desulfovibrio: A genus of gram-negative, anaerobic, rod-shaped bacteria capable of reducing sulfur compounds to hydrogen sulfide. Organisms are isolated from anaerobic mud of fresh and salt water, animal intestines, manure, and feces.Sterilization, Involuntary: Reproductive sterilization without the consent of the patient.Concentration Camps: Facilities in which WARFARE or political prisoners are confined.Toe Joint: The articulation between the head of one phalanx and the base of the one distal to it, in each toe.Lavandula: A plant genus of the LAMIACEAE family.Abscess: Accumulation of purulent material in tissues, organs, or circumscribed spaces, usually associated with signs of infection.Oils, Volatile: Oils which evaporate readily. The volatile oils occur in aromatic plants, to which they give odor and other characteristics. Most volatile oils consist of a mixture of two or more TERPENES or of a mixture of an eleoptene (the more volatile constituent of a volatile oil) with a stearopten (the more solid constituent). The synonym essential oils refers to the essence of a plant, as its perfume or scent, and not to its indispensability.Capsules: Hard or soft soluble containers used for the oral administration of medicine.Wound Healing: Restoration of integrity to traumatized tissue.Brain Abscess: A circumscribed collection of purulent exudate in the brain, due to bacterial and other infections. The majority are caused by spread of infected material from a focus of suppuration elsewhere in the body, notably the PARANASAL SINUSES, middle ear (see EAR, MIDDLE); HEART (see also ENDOCARDITIS, BACTERIAL), and LUNG. Penetrating CRANIOCEREBRAL TRAUMA and NEUROSURGICAL PROCEDURES may also be associated with this condition. Clinical manifestations include HEADACHE; SEIZURES; focal neurologic deficits; and alterations of consciousness. (Adams et al., Principles of Neurology, 6th ed, pp712-6)Liver Abscess: Solitary or multiple collections of PUS within the liver as a result of infection by bacteria, protozoa, or other agents.Cellulitis: An acute, diffuse, and suppurative inflammation of loose connective tissue, particularly the deep subcutaneous tissues, and sometimes muscle, which is most commonly seen as a result of infection of a wound, ulcer, or other skin lesions.Impetigo: A common superficial bacterial infection caused by STAPHYLOCOCCUS AUREUS or group A beta-hemolytic streptococci. Characteristics include pustular lesions that rupture and discharge a thin, amber-colored fluid that dries and forms a crust. This condition is commonly located on the face, especially about the mouth and nose.Erysipeloid: An infection caused by Erysipelothrix rhusiopathiae that is almost wholly restricted to persons who in their occupation handle infected fish, shellfish, poultry, or meat. Three forms of this condition exist: a mild localized form manifested by local swelling and redness of the skin; a diffuse form that might present with fever; and a rare systemic form associated with endocarditis.Aeromonas hydrophila: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria that may be pathogenic for frogs, fish, and mammals, including man. In humans, cellulitis and diarrhea can result from infection with this organism.Staphylococcal Scalded Skin Syndrome: A disease of infants due to group 2 phage type 17 staphylococci that produce an epidermolytic exotoxin. Superficial fine vesicles and bullae form and rupture easily, resulting in loss of large sheets of epidermis.Soft Tissue Infections: Infections of non-skeletal tissue, i.e., exclusive of bone, ligaments, cartilage, and fibrous tissue. The concept is usually referred to as skin and soft tissue infections and usually subcutaneous and muscle tissue are involved. The predisposing factors in anaerobic infections are trauma, ischemia, and surgery. The organisms often derive from the fecal or oral flora, particularly in wounds associated with intestinal surgery, decubitus ulcer, and human bites. (From Cecil Textbook of Medicine, 19th ed, p1688)Erythrasma: A chronic bacterial infection of major folds of the skin, caused by Corynebacterium minutissimum.Avihepadnavirus: A genus of HEPADNAVIRIDAE infecting birds but rarely causing clinical problems. Transmission is predominantly vertical. HEPATITIS B VIRUS, DUCK is the type species.Encephalitis Virus, Eastern Equine: A species of ALPHAVIRUS causing encephalomyelitis in Equidae and humans. The virus ranges along the Atlantic seaboard of the United States and Canada and as far south as the Caribbean, Mexico, and parts of Central and South America. Infections in horses show a mortality of up to 90 percent and in humans as high as 80 percent in epidemics.Rift Valley fever virus: A mosquito-borne species of the PHLEBOVIRUS genus found in eastern, central, and southern Africa, producing massive hepatitis, abortion, and death in sheep, goats, cattle, and other animals. It also has caused disease in humans.Rift Valley Fever: An acute infection caused by the RIFT VALLEY FEVER VIRUS, an RNA arthropod-borne virus, affecting domestic animals and humans. In animals, symptoms include HEPATITIS; abortion (ABORTION, VETERINARY); and DEATH. In humans, symptoms range from those of a flu-like disease to hemorrhagic fever, ENCEPHALITIS, or BLINDNESS.Norwalk virus: The type species in the genus NOROVIRUS, first isolated in 1968 from the stools of school children in Norwalk, Ohio, who were suffering from GASTROENTERITIS. The virions are non-enveloped spherical particles containing a single protein. Multiple strains are named after the places where outbreaks have occurred.Rotavirus: A genus of REOVIRIDAE, causing acute gastroenteritis in BIRDS and MAMMALS, including humans. Transmission is horizontal and by environmental contamination. Seven species (Rotaviruses A thru G) are recognized.Hepatitis B Virus, Duck: A DNA virus that closely resembles human hepatitis B virus. It has been recovered from naturally infected ducks.Bartonellaceae: A family of small gram-negative bacteria whose organisms are parasites of erythrocytes in man and other vertebrates and the etiologic agents of several diseases.Sphingomonas: A genus of gram-negative, aerobic, rod-shaped bacteria characterized by an outer membrane that contains glycosphingolipids but lacks lipopolysaccharide. They have the ability to degrade a broad range of substituted aromatic compounds.Alphaproteobacteria: A class in the phylum PROTEOBACTERIA comprised mostly of two major phenotypes: purple non-sulfur bacteria and aerobic bacteriochlorophyll-containing bacteria.Sphingomonadaceae: A family of gram-negative, asporogenous rods or ovoid cells, aerobic or facultative anaerobic chemoorganotrophs. They are commonly isolated from SOIL, activated sludge, or marine environments.Bartonellaceae Infections: Infections with bacteria of the family BARTONELLACEAE.Proteobacteria: A phylum of bacteria consisting of the purple bacteria and their relatives which form a branch of the eubacterial tree. This group of predominantly gram-negative bacteria is classified based on homology of equivalent nucleotide sequences of 16S ribosomal RNA or by hybridization of ribosomal RNA or DNA with 16S and 23S ribosomal RNA.Caulobacter: A genus of gram-negative, aerobic, rod- or vibroid-shaped or fusiform bacteria that commonly produce a stalk. They are found in fresh water and soil and divide by binary transverse fission.Camellia sinensis: Camellia sinensis L. (formerly Thea sinensis) is an evergreen Asiatic shrub of the THEACEAE family. The infusion of leaves of this plant is used as Oriental TEA which contains CAFFEINE; THEOPHYLLINE; and epigallocatechin gallate.Camellia: A plant genus in the family THEACEAE, order THEALES best known for CAMELLIA SINENSIS which is the source of Oriental TEA.Tanacetum parthenium: An aromatic perennial plant species that has been used to treat migraines, arthritis, and as a febrifuge. It contains TANNINS, volatile oils (OILS, ESSENTIAL), and sesquiterpene lactones, especially parthenolide.Tea: The infusion of leaves of CAMELLIA SINENSIS (formerly Thea sinensis) as a beverage, the familiar Asian tea, which contains CATECHIN (especially epigallocatechin gallate) and CAFFEINE.Lactase: An enzyme which catalyzes the hydrolysis of LACTOSE to D-GALACTOSE and D-GLUCOSE. Defects in the enzyme cause LACTOSE INTOLERANCE.Livestock: Domesticated farm animals raised for home use or profit but excluding POULTRY. Typically livestock includes CATTLE; SHEEP; HORSES; SWINE; GOATS; and others.Spices: The dried seeds, bark, root, stems, buds, leaves, or fruit of aromatic plants used to season food.

Pathogenesis of cancrum oris (noma): confounding interactions of malnutrition with infection. (1/333)

This study showed that impoverished Nigerian children at risk for cancrum oris (noma) had significantly reduced plasma concentrations of zinc (< 10.8 micromol/L), retinol (< 1.05 micromol/L), ascorbate (< 11 micromol/L), and the essential amino acids, with prominently increased plasma and saliva levels of free cortisol, compared with their healthy counterparts. The nutrient deficiencies, in concert with previously reported widespread viral infections (measles, herpesviruses) in the children, would impair oral mucosal immunity. We postulate, subject to additional studies, that evolution of the oral mucosal ulcers including acute necrotizing gingivitis to noma is triggered by a consortium of microorganisms of which Fusobacterium necrophorum is a key component. Fusobacterium necrophorum elaborates several dermonecrotic toxic metabolites and is acquired by the impoverished children via fecal contamination resulting from shared residential facilities with animals and very poor environmental sanitation.  (+info)

Role of gingipains R in the pathogenesis of Porphyromonas gingivalis-mediated periodontal disease. (2/333)

It has been demonstrated that the Porphyromonas gingivalis cysteine proteinases (gingipains) activate and/or degrade a broad range of host proteins. Inactivation of gingipains R prior to infection of mice results in a decrease in the virulence of P. gingivalis. Analysis of mouse, rabbit, and chicken antisera raised to gingipain R1 demonstrated that the hemagglutinin domains of gingipains are very immunogenic; however, immunization of mice with a peptide derived from the hemagglutinin domain did not protect mice from P. gingivalis infection. Our recent studies indicate that immunization of mice with a peptide corresponding to the N-terminus of the catalytic domain of gingipains R results in the generation of an immune response that affords protection of mice from P. gingivalis infection. It is postulated that the protection observed results from the inactivation of the enzymatic activity of gingipains R as a result of antibody recognition of a processing site on the gingipain R precursor.  (+info)

Bacterium-dependent induction of cytokines in mononuclear cells and their pathologic consequences in vivo. (3/333)

Viridans streptococci are a heterogeneous group of gram-positive bacteria that are normal inhabitants of the mouth. These organisms are thought to contribute significantly to the etiology of infective endocarditis, although recently they have been implicated in serious infections in other settings. Another group of oral bacteria, gram-negative anaerobes, is associated with chronic dental infections, such as periodontal diseases or endodontic lesion formation. We evaluated the ability of the oral pathogens Streptococcus mutans and Porphyromonas endodontalis to induce a pathogenic response in vivo, with the goal of quantifying the inflammatory response in soft tissue by measuring leukocyte recruitment and hard tissues by measuring osteoclastogenesis. S. mutans induced a strong inflammatory response and was a potent inducer of osteoclast formation, while P. endodontalis was not. To further study the mechanisms by which P. endodontalis and S. mutans elicit significantly different levels of inflammatory responses in vivo, we tested the capacity of each to induce production of cytokines by mononuclear cells in vitro. S. mutans stimulated high levels of interleukin-12 (IL-12), gamma interferon (IFN-gamma), and tumor necrosis factor alpha (TNF-alpha), all of which are associated with inflammation, enhanced monocyte function, and generation of a Th1 response. In contrast, P. endodontalis stimulated production of IL-10 but not of TNF-alpha, IL-12, or IFN-gamma. These results demonstrate that oral pathogens differ dramatically in their abilities to induce inflammatory and immunoregulatory cytokines. Moreover, there is a high degree of correlation between the cytokine profile induced by these bacteria in vitro and their pathogenic capacity in vivo.  (+info)

Molecular interactions of Porphyromonas gingivalis fimbriae with host proteins: kinetic analyses based on surface plasmon resonance. (4/333)

Fimbriae of Porphyromonas gingivalis are thought to play an important role in the colonization and invasion of periodontal tissues. In this study, we analyzed the interactions of P. gingivalis fimbriae with human hemoglobin, fibrinogen, and salivary components (i.e., proline-rich protein [PRP], proline-rich glycoprotein [PRG], and statherin) based on surface plasmon resonance (SPR) spectroscopy with a biomolecular interaction analyzing system (BIAcore). The real-time observation showed that the fimbriae interacted more quickly with hemoglobin and PRG than with other proteins and more intensely with fibrinogen. The significant association constant (ka) values obtained by BIAcore demonstrated that the interactions between fimbriae and these host proteins are specific. These estimated Ka values were not too different; however, the Ka values for hemoglobin (2.43 x 10(6)) and fibrinogen (2.16 x 10(6)) were statistically greater than those for the salivary proteins (1.48 x 10(6) to 1.63 x 10(6)). The Ka value of anti-fimbriae immunoglobulin G for fimbriae was estimated to be 1. 22 x 10(7), which was 6.55-fold higher than the mean Ka value of the host proteins. Peptide PRP-C, a potent inhibitor of PRP-fimbriae interaction, dramatically inhibited fimbrial association to PRP and PRG and was also inhibitory against other host proteins by BIAcore. The binding of fimbriae to these proteins was also evaluated by other methods with hydroxyapatite beads or polystyrene microtiter plates. The estimated binding abilities differed considerably, depending on the assay method that was used. It was noted that the binding capacity of PRP was strongly diminished by immobilization on a polystyrene surface. Taken together, these findings suggest that P. gingivalis fimbriae possess a strong ability to interact with the host proteins which promote bacterial adherence to the oral cavity and that SPR spectroscopy is a useful method for analyzing specific protein-fimbriae interactions.  (+info)

CD4(+) T cells and the proinflammatory cytokines gamma interferon and interleukin-6 contribute to alveolar bone loss in mice. (5/333)

In this study, we used a mouse model to examine the role of the adaptive immune response in alveolar bone loss induced by oral infection with the human gram-negative anaerobic bacterium Porphyromonas gingivalis. Severe combined immunodeficient mice, which lack B and T lymphocytes, exhibited considerably less bone loss than did immunocompetent mice after oral infection, suggesting that lymphocytes contribute to this process. Bone loss after oral infection was decreased in mice deficient in major histocompatibility complex (MHC) class II-responsive CD4(+) T cells, but no change in bone loss was observed in mice deficient in MHC class I-responsive CD8(+) T cells or NK1(+) T cells. Mice lacking the cytokine gamma interferon or interleukin-6 also demonstrated decreased bone loss. These results suggest that the adaptive immune response, and in particular CD4(+) T cells and the proinflammatory cytokines that they secrete, are important effectors of bone loss consequent to P. gingivalis oral infection. The studies also reinforce the utility of the mouse oral infection model in dissecting the pathobiology of periodontal disease.  (+info)

Purification, characterization, and sequence analysis of a potential virulence factor from Porphyromonas gingivalis, peptidylarginine deiminase. (6/333)

The initiation and progression of adult-onset periodontitis has been associated with infection of the gingival sulcus by Porphyromonas gingivalis. This organism utilizes a multitude of virulence factors to evade host defenses as it establishes itself as one of the predominant pathogens in periodontal pockets. A feature common to many other oral pathogens is the production of ammonia due to its protective effect during acidic cleansing cycles in the mouth. Additionally, ammonia production by P. gingivalis has been proposed as a virulence factor due to its negative effects on neutrophil function. In this study, we describe the first purification of a peptidylarginine deiminase (PAD) from a prokaryote. PAD exhibits biochemical characteristics and properties that suggest that it may be a virulence agent. PAD deiminates the guanidino group of carboxyl-terminal arginine residues on a variety of peptides, including the vasoregulatory peptide-hormone bradykinin, to yield ammonia and a citrulline residue. The soluble protein has an apparent mass of 46 kDa, while the DNA sequence predicts a full-length protein of 61.7 kDa. PAD is optimally active at 55 degrees C, stable at low pH, and shows the greatest activity above pH 9.0. Interestingly, in the presence of stabilizing factors, PAD is resistant to limited proteolysis and retains significant activity after short-term boiling. We propose that PAD, acting in concert with arginine-specific proteinases from P. gingivalis, promotes the growth of the pathogen in the periodontal pocket, initially by enhancing its survivability and then by assisting the organism in its circumvention of host humoral defenses.  (+info)

Host responses to recombinant hemagglutinin B of Porphyromonas gingivalis in an experimental rat model. (7/333)

Porphyromonas gingivalis, a gram-negative, black-pigmented anaerobe, is among the microorganisms implicated in the etiology of adult periodontal disease. This bacterium possesses a number of factors, including hemagglutinins, of potential importance in virulence. Several hemagglutinin genes have been identified, cloned, and expressed in Escherichia coli. The purpose of this study was to characterize host responses to purified recombinant hemagglutinin B (rHag B), using the conventional Fischer rat as the experimental animal model. The effectiveness of immunization with rHag B on protection against experimental periodontal bone loss following infection with P. gingivalis was also evaluated. Groups of rats were immunized by the subcutaneous route with rHag B in complete Freund's adjuvant, immunized with rHag B and orally infected with P. gingivalis, nonimmunized and noninfected, or orally infected with P. gingivalis only. Serum and saliva samples were collected throughout the experiment and evaluated for serum immunoglobulin G (IgG) and IgM and salivary IgA antibody activity by enzyme-linked immunosorbent assay. No salivary IgA anti-Hag B activity was detected in the various groups of rats. A slight serum IgM response similar to that seen in preimmune samples was observed. Serum IgG antibody activity to Hag B was detected only in samples from rats immunized with rHag B. This response was primarily of the IgG1 and IgG2a subclasses, followed by IgG2b and low levels of IgG2c. Supernatants from rHag B-stimulated splenic lymphoid cell cultures from immunized rats contained high levels of gamma interferon, followed by interleukin-2 (IL-2), IL-10, and then IL-4. These results are consistent with the induction of T helper type 1 (Th1)- and Th2-like responses. Western blot analysis of sera derived from rHag B-immunized rats reacted with trichloroacetic acid (TCA) precipitates of P. gingivalis 33277, 381, A7A1-28, and W50, revealing a 50-kDa band reflective of Hag B. However, sera derived from rats immunized with P. gingivalis whole cells or from rats infected with P. gingivalis only did not react with rHag B but did react with TCA precipitates of P. gingivalis strains. Finally, radiographic measurements of periodontal bone loss indicated that rats immunized with rHag B had less bone loss than those infected with P. gingivalis only. These results demonstrate the effectiveness of purified rHag B in inducing a protective immune response and support the potential usefulness of this component of P. gingivalis in the development of a vaccine against adult periodontitis.  (+info)

Direct detection of Prevotella intermedia and P. nigrescens in suppurative oral infection by amplification of 16S rRNA gene. (8/333)

A specific 16S rDNA PCR and subsequent hybridisation reaction was designed to discriminate between strains of Prevotella intermedia (n = 15) and P. nigrescens (n = 15). This technique was then used to detect the presence of these two bacterial species in acute suppurative oral infection. A total of 36 pus samples aspirated from 26 peri-apical abscesses, three root canals, three periodontal abscesses, two cases of refractory periodontitis, one cyst and one haematoma was examined. A portion of the pus sample was processed by PCR and the remainder of the specimen was subjected to routine culture. The PCR-based technique gave an identical pattern of detection of P. intermedia or P. nigrescens to that obtained by culture for 30 of the 36 specimens. Either P. intermedia or P. nigrescens was present in 14 samples and neither species was detected in 16 samples. In the remaining six samples the PCR method indicated the presence of one (n = 3) or both (n = 3) of the Prevotella species but neither or only one species was isolated by culture. It is concluded that the presence of P. intermedia and P. nigrescens in pus can be detected rapidly and specifically by direct PCR amplification of 16S rDNA. P. nigrescens was detected more frequently than P. intermedia in suppurative peri-apical infection both by culture and PCR.  (+info)

*List of MeSH codes (C01)

... bacteroidaceae infections MeSH C01.252.400.110.109 --- bacteroides infections MeSH C01.252.400.126 --- bartonellaceae ... acinetobacter infections MeSH C01.252.400.610 --- mycoplasmatales infections MeSH C01.252.400.610.610 --- mycoplasma infections ... bordetella infections MeSH C01.252.400.143.740 --- whooping cough MeSH C01.252.400.155 --- borrelia infections MeSH C01.252. ... proteus infections MeSH C01.252.400.310.821 --- salmonella infections MeSH C01.252.400.310.821.438 --- paratyphoid fever MeSH ...

*Bacteroides fragilis

The B. fragilis group is the most commonly isolated Bacteroidaceae in anaerobic infections, especially those that originate ... It is part of the normal flora of the human colon and is generally commensal, but can cause infection if displaced into the ... Bacteroides infections at eMedicine Brook I (June 2010). "The role of anaerobic bacteria in bacteremia". Anaerobe. 16 (3): 183- ... ISBN 0-443-06643-4. Brook I (December 2007). "Treatment of anaerobic infection". Expert Rev Anti Infect Ther. 5 (6): 991-1006. ...
Periodontitis is a chronic inflammatory disease caused by exaggerated host immune responses to dysregulated microbiota in dental biofilms leading to degradation of tissues and alveolar bone loss. Porphyromonas gingivalis is a major periodontal pathogen and expresses several potent virulence factors. Among these factors, arginine and lysine gingipains are of special importance, both for the bacterial survival/proliferation and the pathological outcome. The major aim of this thesis was to develop and test novel methods for diagnosis and prevention of P. gingivalis infection and periodontitis. In study I, anti-P. gingivalis antibodies were developed in vitro for immunodetection of bacteria in clinical samples using a surface plasmon resonance (SPR)-based biosensor. Specific binding of the antibodies to P. gingivalis was demonstrated in samples of patients with periodontitis and the results were validated using real-time PCR and DNA-DNA checkerboard analysis. In study II, we elucidated the ...
The pathogenicity of the periodontal biofilm is highly dependent on a few key species, of which Porphyromonas gingivalis is considered to be one of the most important pathogens. P. gingivalis expresses a broad range of virulence factors, of these cysteine proteases (gingipains) are of special importance both for the bacterial survival/proliferation and for the pathological outcome. Several cell types, for example, epithelial cells, endothelial cells, dendritic cells, osteoblasts, and fibroblasts, reside in the periodontium and are part of the innate host response, as well as platelets, neutrophils, lymphocytes, and monocytes/macrophages. These cells recognize and respond to P. gingivalis and its components through pattern recognition receptors (PRRs), for example, Toll-like receptors and protease-activated receptors. Ligation of PRRs induces downstream-signaling pathways modifying the activity of transcription factors that regulates the expression of genes linked to inflammation. This is followed by the
Yes. Theres a lot of discussion about it. So, first of all, its a risk factor. So, often, when you see p. gingivalis, or when you see periodontitis, you often see, also, other diseases like diabetes. So, but, they showed the association. But the problem is: both diseases; or a lot of diseases, like cardiovascular diseases; are so complex and caused by different factors, thats its very difficult to find 1 cause or 1 relation. So, there has never been a causal relationship that has been demonstrated. So, what I can say is, maybe, if you have periodontitis with p. gingivalis, there are studies that demonstrate, so: the invasiveness of p. gingivalis. It can go to the liver, and there it can interact with the process of the glucose mechanism. So, the invasiveness, first of all: p. gingivalis makes that it may ... yes, I would say: induce the diabetes. But, on the other hand; you see, for diabetes patients, the problem is there: they may have a loss in bone density. And when you see to the ...
Principal Investigator:TSUKUBA Tomoko, Project Period (FY):2004 - 2005, Research Category:Grant-in-Aid for Scientific Research (C), Section:一般, Research Field:Functional basic dentistry
Researchers at the University at Buffalo have been able to identify two key components in saliva that could be used to predict the amount of oral bone loss in future.
K-antigen capsule is one of the key virulence factors of the oral pathogen Porphyromonas gingivalis. This cell surface structure is synthesized by proteins encoded by a series of genes in an operon that is transcribed as a large polycistronic message. Previously, a 77-bp inverted repeat region was identified upstream of the start codon of PG0106, the first gene in the synthesis cluster, and this inverted repeat was predicted to form a large stem-loop structure. Furthermore, two genes that flank the synthesis cluster (PG0104 and PG0121) were also found to be co-transcribed with the K-antigen capsule synthesis operon. Interestingly, these genes are both predicted to encode DNA binding proteins; indicated by their high similarity to other known DNA binding proteins. PG0104 shares a 57% sequence similarity to DNA topoisomerase III from Bacillus subtilis, while PG0121 is 72% similar to DNA binding protein HU of Bacillus caldotenax. The transcript levels of the K-antigen capsule synthesis genes in ...
K-antigen capsule is one of the key virulence factors of the oral pathogen Porphyromonas gingivalis. This cell surface structure is synthesized by proteins encoded by a series of genes in an operon that is transcribed as a large polycistronic message. Previously, a 77-bp inverted repeat region was identified upstream of the start codon of PG0106, the first gene in the synthesis cluster, and this inverted repeat was predicted to form a large stem-loop structure. Furthermore, two genes that flank the synthesis cluster (PG0104 and PG0121) were also found to be co-transcribed with the K-antigen capsule synthesis operon. Interestingly, these genes are both predicted to encode DNA binding proteins; indicated by their high similarity to other known DNA binding proteins. PG0104 shares a 57% sequence similarity to DNA topoisomerase III from Bacillus subtilis, while PG0121 is 72% similar to DNA binding protein HU of Bacillus caldotenax. The transcript levels of the K-antigen capsule synthesis genes in ...
Methods: in vivo laboratory, experimental research was conducted using posttest only control group design. The samples were 20 male Wistar rats divided into 4 groups. Groups I and II were groups injected using LPS P. gingivalis for 6 w and were decapited on the day 3 and day 7, groups III and IV were the control groups (not injected using LPS P. gingivalis) and decapited on the day 3 and day 7. Subsequently, conducting tissue preparation, staining using haematoxilin eosin, and calculating the number of osteoclasts and osteoblasts cells using a microscope (Optilab) with 400x magnification. The results of osteoblast and osteoclast cell calculation were analyzed using ANOVA and LSD one-way test. ...
Atherosclerotic vascular disease is a leading cause of myocardial infarction and cerebrovascular accident, and independent associations with periodontal disease (PD) are reported. PD is caused by polymicrobial infections and aggressive immune responses. Genomic DNA of Porphyromonas gingivalis, the best-studied bacterial pathogen associated with severe PD, is detected within atherosclerotic plaque. We examined causal relationships between chronic P. gingivalis oral infection, PD, and atherosclerosis in hyperlipidemic ApoEnull mice. ApoEnull mice (n = 24) were orally infected with P. gingivalis for 12 and 24 weeks. PD was assessed by standard clinical measurements while the aorta was examined for atherosclerotic lesions and inflammatory markers by array. Systemic inflammatory markers serum amyloid A, nitric oxide, and oxidized low-density lipoprotein were analyzed. P. gingivalis infection elicited specific antibodies and alveolar bone loss. Fluorescent in situ hybridization detected viable P. gingivalis
Porphyromonas gingivalis ATCC ® BAA-308D-5™ Designation: Genomic DNA from Porphyromonas gingivalis strain W83 TypeStrain=False Application:
Periodontitis is a chronic infectious disease that is highly prevalent worldwide and is characterized by inflammation of the gums, and loss of connective tissue and bone support. The Gram-negative anerobic bacterium Porphyromonas gingivalis is generally accepted as the main etiological agent for chronic periodontitis. The objective of this paper is to elucidate the feasibility of achieving protection against periodontitis though immunization against P. gingivalis. Until now, animal studies have showed no complete protection against P. gingivalis. However, current knowledge about P. gingivalis structures could be applicable for further research to develop a successful licensed vaccine and alternative therapeutic strategies. This review reveals that a multicomponent vaccine against P. gingivalis, which includes structures shared among P. gingivalis serotypes, will be feasible to induce broad and complete protection ...
The suitability of a mouse model for host response in the induction of alveolar bone loss by Porphyromonas gingivalis was explored. The mouths of immunocompetent and severe combined immunodeficient (SCID) mice were infected with P. gingivalis ATCC 53977. P. gingivalis was not isolated from the mouths of these mice before infection, but was present at least 42 days after infection. P. gingivalis-specific IgG was present in sera from the infected, immunocompetent mice at the end of these experiments (42 days). Specific IgG was not present in sham-infected or uninfected immunocompetent mice, nor in any immunodeficient mice. Specific IgM was not present in any sera at 42 days. Infected, immunocompetent mice of two strains showed significant bone loss in comparison to sham-infected or uninfected immunocompetent mice (p | 0.05). Infected SCID mice, which are genetically lacking both B and T lymphocytes, also showed significant bone loss compared with sham-infected or uninfected SCID mice (p | 0.05
Porphyromonas gingivalis is a highly proteolytic organism which metabolizes small peptides and amino acids. Indirect evidence suggests that the proteases produced by this microorganism constitute an important virulence factor. In this study, a gene bank of P. gingivalis W83 DNA was constructed by cloning 0.5- to 20-kb HindIII-cut DNA fragments into Escherichia coli DH5 alpha by using the plasmid vector pUC19. A clone expressing a protease from P. gingivalis was isolated on LB agar containing 1% skim milk. The clone contained a 3.0-kb insert that coded for a protease with an apparent molecular mass of 64 kDa. Sequencing part of the 3.0-kb DNA fragment revealed an open reading frame encoding a protein of 482 amino acids with a molecular mass of 62.5 kDa. Putative promoter and termination elements flanking the open reading frame were identified. The activity expressed in E. coli was extensively characterized by using various substrates and protease inhibitors, and the results suggest that it is ...
Chronic periodontitis is strongly associated with composition of the oral biofilm occupying the gingival crevicular aspect of the tooth and its associated root. Some gram-negative, red complex bacteria instigate periodontal bone loss in patients, principal among these Porphyromonas gingivalis. P. gingivalis is a late colonizer, indicating not only its physical location within the oral biofilm, but also the pathogenic dynamic of the interaction between P. gingivalis and the host innate immunity. Among several other subversive tactics, P. gingivalis has been shown to compel receptors vital to the orchestration of an appropriate immune response to co-associate and consequently signal in a way that directly benefits the pathogen. Upon interaction with human monocytes and murine macrophages, P. gingivalis has been shown to induce TLR2 and CXCR4 to co- associate in lipid rafts via its surface fimbriae. The ensuing crosstalk results in a cAMP dependent, PKA mediated inhibition of NF-KB which in turn leads
Toll-like receptors (TLRs) are a group of pathogen-associated molecular pattern receptors, which play an important role in in-nate immune signaling in response to microbial infection. It has been demonstrated that TLRs are differentially up regulated in response to microbial infection and chronic inflammatory diseases such as atherosclerosis. Furthermore hyperlipidemic mice deficient in TLR2, TLR4, and MyD88 signaling exhibit diminished inflammatory responses and decreased atherosclerosis. Accumulating evidence has implicated specific infectious agents including the periodontal disease pathogen Porphyromonas gingivalis in the progression of atherosclerosis. Evidence in humans suggesting that periodontal infection predisposes to atherosclerosis is derived from studies demonstrating that the periodontal pathogen P. gingivalis resides in the wall of atherosclerotic vessels and seroepidemiological studies demonstrating an association between pathogen-specific IgG antibodies and atherosclerosis. We ...
Outer membrane protein A (OmpA) is a key outer membrane protein found in Gram-negative bacteria that contributes to several crucial processes in bacterial virulence. In Porphyromonas gingivalis, OmpA is predicted as a heterotrimer of OmpA1 and OmpA2 subunits encoded by adjacent genes. Here we describe the role of OmpA and its individual subunits in the interaction of P. gingivalis with oral cells. Using knockout mutagenesis, we show that OmpA2 plays a significant role in biofilm formation and interaction with human epithelial cells. We used protein structure prediction software to identify extracellular loops of OmpA2, and determined these are involved in interactions with epithelial cells as evidenced by inhibition of adherence and invasion of P. gingivalis by synthetic extracellular loop peptides and the ability of the peptides to mediate interaction of latex beads with human cells. In particular, we observe that OmpA2-loop 4 plays an important role in the interaction with host cells. These ...
Periodontal disease is of established aetiology in which polymicrobial synergistic ecology has become dysbiotic under the influence of Porphyromonas gingivalis. Following breakdown of the hosts protective oral tissue barriers, P. gingivalis migrates to developing inflammatory pathologies that associate with Alzheimers disease (AD). Periodontal disease is a risk factor for cardiovascular disorders (CVD), type II diabetes mellitus (T2DM), AD and other chronic diseases, whilst T2DM exacerbates periodontitis. This study analysed the relationship between the P. gingivalis/host interactome and the genes identified in genome-wide association studies (GWAS) for the aforementioned conditions using data from GWASdb (P
Porphyromonas gingivalis porphypain protein: isolated from Prophyromonas gingivalis W12; amino acid sequence in first source; GenBank U42210; do not confuse with PrtP from Lactococcus
Porphyromonas gingivalis KGP-381 protein: gene kgp(381) has high homology with the proteolytic domain of cysteine proteases/hemagglutination genes; MW 40 kDa; amino acid sequence in first source
Characterization of a second cell-associated Arg-specific cysteine proteinase of Porphyromonas gingivalis and identification of an adhesin-binding motif involved in association of the prtR and prtK proteinases and adhesins into large complexes
Results Intratracheal infection with 5x107 P. gingivalis did not lead to systemic infection and live bacteria were eliminated twenty-four hours postinfection from the lungs. Moreover, no live bacteria were found in other organs and blood at any time after bacterial administration. However, significant ankle swelling occurred in DBA/1 mice 7 days after P. gingivalis challenge. In contrast to DBA/1, BALB/c and C57BL/6 mice were resistant to joint inflammation generated by P. gingivalis intratracheal infection. The arthritic joints in DBA/1 mice exhibited inflammatory changes in synovial tissue. Serum proinflammatory mediators such as IL-6, TNF-alpha, IL-10, MCP-1 were found to be elevated one week after infection, which correlated with the onset of inflammatory changes in the joints.. Other routes of P. gingivalis administration did not lead to inflammatory changes in the joints.. ...
Porphyromonas gingivalis (P.Gingivalis) es un microorganismo comprometido en el inicio y progresión de la enfermedad periodontal crónica y agresiva, y es considerado su principal agente etiológico. Esta bacteria cuenta con una serie defactores de virulencia que le permiten, iniciar el proceso infeccioso, perpetuar la infección y también transformar la placa dental benigna en una comunidad microbiana patógena. Estudiar sus factores de virulencia y su capacidad de modular la respuesta inmunológica del huésped es muy importante para comprender el papel de este patógeno en el desarrollo y establecimiento de la enfermedad. Esta revisión proporciona una visión actual sobre los factores de virulencia y su impacto sobre la respuesta inmunológica en relación con la patogénesis de la enfermedad periodontal. Porphyromonas gingivalis (P. Gingivalis) is a microorganism involved in the onset and progression of chronic and aggressive periodontal disease, and is considered its main etiological ...
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
Principal Investigator:田中 雅子, Project Period (FY):1991, Research Category:Grant-in-Aid for Encouragement of Young Scientists (A), Research Field:Morphological basic dentistry
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Comparison of P. gingivalis HmuY and its homologs from P. intermedia and T. forsythia.Amino acid alignment (A) and approximated protein structures (B). P. inter
It has been demonstrated that the Porphyromonas gingivalis cysteine proteinases (gingipains) activate and/or degrade a broad range of host proteins. Inactivation of gingipains R prior to infection of mice results in a decrease in the virulence of P. gingivalis. Analysis of mouse, rabbit, and chicken antisera raised to gingipain R1 demonstrated that the hemagglutinin domains of gingipains are very immunogenic; however, immunization of mice with a peptide derived from the hemagglutinin domain did not protect mice from P. gingivalis infection. Our recent studies indicate that immunization of mice with a peptide corresponding to the N-terminus of the catalytic domain of gingipains R results in the generation of an immune response that affords protection of mice from P. gingivalis infection. It is postulated that the protection observed results from the inactivation of the enzymatic activity of gingipains R as a result of antibody recognition of a processing site on the gingipain R precursor.. ...
Background: Porphyromonas gingivalis is a gram-negative bacterium that causes destructive chronic periodontitis. In addition, this bacterium is also involved in the development of cardiovascular disease. The aim of this study was to investigate the effects of P. gingivalis infection on gene and protein expression in human aortic smooth muscle cells (AoSMCs) and its relation to cellular function.. Results: AoSMCs were exposed to viable P. gingivalis for 24 h, whereafter confocal fluorescence microscopy was used to study P. gingivalis invasion of AoSMCs. AoSMCs proliferation was evaluated by neutral red assay. Human genome microarray, western blot and ELISA were used to investigate how P. gingivalis changes the gene and protein expression of AoSMCs. We found that viable P. gingivalis invades AoSMCs, disrupts stress fiber structures and significantly increases cell proliferation. Microarray results showed that, a total of 982 genes were identified as differentially expressed with the threshold log2 ...
Porphyromonas gingivalis, the major etiologic agent of chronic periodontitis, produces a broad spectrum of virulence factors, including Arg- and Lys-gingipain cysteine proteinases. In this study, we investigated the capacity of P. gingivalis gingipains to trigger a proinflammatory response in human monocyte-derived macrophages. Both Arg- and Lys-gingipain preparations induced the secretion of TNF-α and IL-8 by macrophages. Stimulation of macrophages with Arg-gingipain A/B preparation at the highest concentration was associated with lower amounts of cytokines detected, a phenomenon likely related to proteolytic degradation. The inflammatory response induced by gingipains was not dependent of their catalytic activity since heat-inactivated preparations were still effective. Stimulating macrophages with gingipain preparations was associated with increased levels of phosphorylated p38α MAPK suggesting its involvement in cell activation. In conclusion, our study brought clear evidence that P. gingivalis
Porphyromonas gingivalis, a periodontal pathogen, can invade primary cultures of gingival epithelial cells. Optimal invasion occurred at a relatively low multiplicity of infection (i.e., 100) and demonstrated saturation at a higher multiplicity of infection. Following the lag phase, during which bacteria invaded poorly, invasion was independent of growth phase. P. gingivalis was capable of replicating within the epithelial cells. Invasion was an active process requiring both bacterial and epithelial cell energy production. Invasion was sensitive to inhibitors of microfilaments and microtubules, demonstrating that epithelial cell cytoskeletal rearrangements are involved in bacterial entry. P. gingivalis, but not epithelial cell, protein synthesis was necessary for invasion. Invasion within the epithelial cells was not blocked by inhibitors of protein kinase activity. Invasion was inhibited by protease inhibitors, suggesting that P. gingivalis proteases may be involved in the invasion process. ...
TY - JOUR. T1 - Innate immune recognition of invasive bacteria accelerates atherosclerosis in apolipoprotein E-deficient mice. AU - Gibson, Frank C.. AU - Hong, Charlie. AU - Chou, Hsin H.. AU - Yumoto, Hiromichi. AU - Chen, Jiqiu. AU - Lien, Egil. AU - Wong, Jodie. AU - Genco, Caroline Attardo. PY - 2004/6/8. Y1 - 2004/6/8. N2 - Background - Infectious diseases have emerged as potential risk factors for cardiovascular disease (CVD). Epidemiological studies support a connection between periodontal disease, a chronic inflammatory disease of the supporting tissues of the teeth, and CVD. Methods and Results - To directly test the connection between periodontal disease and atherosclerosis, apoE-/- mice were orally challenged with the periodontal disease pathogen Porphyromonas gingivalis or an invasion-impaired P gingivalis fimbriae-deficient mutant (FimA-). Both wild-type P gingivalis and the FimA- mutant were detected in blood and aortic arch tissue of apoE-/- mice by PCR after challenge. ApoE-/- ...
Gln-70, which is located near the active-site metal, is conserved in aligned amino acid sequences of iron-containing superoxide dimutases (Fe-SODs) and cambialistic SOD from Porphyromonas gingivalis, but is complementarily substituted with Gln-142 in manganese-containing SODs (Mn-SODs). In order to clarify the contribution of this exchange of Gln to the metal-specific activity of P. gingivalis SOD, we have prepared a mutant of the enzyme with conversions of Gln-70 to Gly and Ala-142 to Gln. The ratio of the specific activities of Mn- to Fe-reconstituted P. gingivalis SOD increased from 1.4 in the wild-type to 3.5 in the mutant SODs. Furthermore, the visible absorption spectra of the Mn- and Fe-reconstituted mutant SODs more closely resembled that of Mn-specific SOD than that of the wild-type SOD. We conclude that a difference in configuration of the Gln residues of P. gingivalis SOD partially accounts for the metal-specific activity of the enzyme.. ...
Download Free Full-Text of an article Study of Porphyromonas gingivalis in periodontal diseases: A systematic review and meta-analysis
Summary The sequence of events involved in haemagglutination and lysis of erythrocytes by washed cells, vesicles and the culture supernate of Porphyromonas gingivalis strain W83 was monitored by 51Cr release and transmission electronmicroscopy. All preparations, except capsular material and lipopolysaccharide, caused haemagglutination and, by a slow process of attachment and specific attack on the surface structures of the red blood cells, produced minute pores and eventual leakage of cellular contents. N-acetylglucosamine, N-acetylgalactosamine and several other sugars such as glucose and sucrose had no effect on haemagglutination. Antiserum raised against a cloned haemagglutinin of P. gingivalis strain 381 inhibited the activity of strain W83 cells, vesicles and supernate. The antiserum-neutralised supernate lost 70-80% of its hydrolytic activity towards α-N-benzoyl-L-arginine-4-nitroanilide but the residual activity behaved in a manner similar to the native supernate in that it was completely
Looking for online definition of sulcus gingivalis in the Medical Dictionary? sulcus gingivalis explanation free. What is sulcus gingivalis? Meaning of sulcus gingivalis medical term. What does sulcus gingivalis mean?
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Three-dimensional (3D) printing has been applied extensively not only in human, but also veterinary medicine. However, the technique is still used in the clinical area for a surgical plan or education prior to surgery. Thus, we report a case of reconstruction after tumor removal surgery with the use of a 3D-printed scaffold. A 12-year-old female mixed dog had a left caudal maxillary mass. Based on computed tomography images, a defect was confirmed on the maxillary bone due to the oral mass, and a surgical plan was designed to remove the oral mass and graft the 3D printed scaffold ...
Ultrastructure of the AgB oligomers analyzed by TEM.TEM images from rAgB8/1 (A), rAgB8/2 (B), rAgB8/3 (C), and AgB (D) oligomers. Recombinant AgB subunits were
Jual Rumah Rp 600juta, Depok Parung Bingung dekat Kubah Emas, Pas Belakang Rumah Sakit Asy-Syifa dan di belakang Sekolah Alam Jl. Meruyung. Di dalam Komplek ada PAUD di samping Mushola. LB 83m2, LT 143m2, Car Port, 2 Kamar Tembok, 1 Kamar Sekat, Ruang Tamu, Dapur, 2 Kamar Mandi, 1 Gudang, Taman Depan dan Belakang ...
The polymicrobial dysbiotic subgingival biofilm microbes associated with periodontal disease appear to contribute to developing pathologies in distal body sites, including the brain. This study examined oxidative stress, in the form of increased protein carbonylation and oxidative protein damage, in the tumour necrosis factor-α (TNF-α) transgenic mouse that models inflammatory TNF-α excess during bacterial infection; and in the apolipoprotein knockout (ApoE-/-) mouse brains, following Porphyromonas gingivalis gingival monoinfection. Following 2,4-dinitrophenylhydrazine derivatization, carbonyl groups were detected in frontal lobe brain tissue lysates by immunoblotting and immunohistochemical analysis of fixed tissue sections from the frontotemporal lobe and the hippocampus. Immunoblot analysis confirmed the presence of variable carbonyl content and oxidative protein damage in all lysates, with TNF-α transgenic blots exhibiting increased protein carbonyl content, with consistently prominent ...
The chemical structure of lipid A isolated from Porphyromonas gingivalis lipopolysaccharide was elucidated by compositional analysis, mass spectrometry, and nuclear magnetic resonance spectroscopy. The hydrophilic backbone of free lipid A was found to consisted of beta(1,6)-linked D-glucosamine disaccharide 1-phosphate. (R)-3-Hydroxy-15-methylhexadecanoic acid and (R)-3-hydroxyhexadecanoic acid are attached at positions 2 and 3 of the reducing terminal residue, respectively, and positions 2 and 3 of the nonreducing terminal unit are acylated with (R)-3-O-(hexadecanoyl)-15-methylhexadecanoic acid and (R)-3-hydroxy-13-methyltetradecanoic acid, respectively. The hydroxyl group at position 4 is partially replaced by another phosphate group, and the hydroxyl groups at positions 4 and 6 are unsubstituted. Considerable heterogeneity in the fatty acid chain length and the degree of acylation and phosphorylation was detected by liquid secondary ion-mass spectrometry (LSI-MS). A significant ...
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Buy kgp recombinant protein, Lys-gingipain Recombinant Protein-YP_001929844.1 (MBS969701) product datasheet at MyBioSource, Recombinant Proteins
#medicinal chemistry #Iminoguanidines as Allosteric Inhibitors of the Iron-Regulated Heme Oxygenase (HemO) of Pseudomonas aeruginosa Pseudomonas aeruginosa |Geoffrey A. Heinzl, Weiliang Huang, Wenbo Yu, Bennett J. Giardina, Yue Zhou, Alexander D. MacKerellJr. Angela Wilks*, and Fengtian Xue* Porphyromonas gingivalis -Induced Pro-inflammatory Effects by High Doses of Muramyl Dipeptide | Porphyromonas gingivalis -Induced Pro-inflammatory Effects by…
... adalah suatu inflamasi purulen yang terlokalisir pada jaringan periodonsium. Abses periodontal ini dapat diklasifikasikan berdasarkan lokasi abses (abses gingiva, abses periodontal dan abses perikoronal), berdasarkan jalannya lesi (abses periodontal akut dan abses periodontal kronis) dan berdasarkan jumlah abses (abses periodontal tunggal dan abses periodontal kronis). Abses periodontal merupakan kasus darurat penyakit periodontal ketiga yang paling sering terjadi. Etiologi terjadinya abses periodontal dapat dibagi atas dua yaitu abses yang berhubungan dengan periodontitis dan yang tidak berhubungan dengan periodontitis. Bakteri yang paling banyak ditemukan pada abses periodontal adalah Porphyromonas gingivalis, Provotella intermedia dan Fusobakterium nucleatum. Abses periodontal dapat menyebabkan kehilangan gigi dan penyebaran infeksi. Diagnosis abses periodontal diperoleh berdasarkan gejala-gejala yang dijumpai pada pemeriksaan klinis, pemeriksaan radiografi, keluhan-keluhan ...
森 修二 , 広瀬 公治 , 大井戸 真理 , 室 三之 , 磯貝 恵美子 , 中島 啓介 , 上田 五男 , 小鷲 悠典 日本歯周病学会会誌 40(1), 58-65, 1998-03-28 CiNii PDF - オープンアクセス J-STAGE 医中誌Web 参考文献22件 被引用文献2件 ...
TY - JOUR. T1 - Cloning and sequencing of the gene encoding a novel lysine-specific cysteine proteinase (Lys-Gingipain) in porphyromonas gingivalis. T2 - Structural relationship with the arginine-specific cysteine proteinase (Arg-Gingipain). AU - Okamoto, Kuniaki. AU - Kadowaki, Tomoko. AU - Nakayama, Koji. AU - Yamamoto, Kenji. PY - 1996. Y1 - 1996. N2 - Lys-gingipain (KGP), so termed due to its peptide cleavage specificity for lysine residues, is a cysteine proteinase produced by the Gram-negative anaerobic bacterium Porphyromonas gingivalis. Mixed oligonucleotide primers designed from the NH2-terminal sequence of the purified enzyme were used to clone the KGP-encoding gene (kgp) from the organism. The nucleotide sequence of kgp had a 5,169-bp open reading frame encoding 1,723 amino acids with a calculated molecular mass of 218 kDa. As the extracellular mature enzyme had an apparent molecular mass of 51 kDa in gels, the precursor of KGP was found to comprise at least four domains, the signal ...
Tobacco Smoke Augments Porphyromonas gingivalis - Streptococcus gordonii Biofilm Formation. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
While the 16S ribosomal gene is the standard for distinguishing among bacterial species, it is insufficiently variable among P. gingivalis strains for resolution. The ribosomal ISR is the most variable portion of the ribosomal operon and is sufficiently variable within a species to resolve strains (18). This locus also offers a technical advantage since it can be amplified with species-specific and conserved primers in the 16S and 23S ribosomal genes, thus avoiding the need to culture bacteria from clinical specimens. There are four copies of the ribosomal operon in P. gingivalis (P. gingivalis genome project [http://www.forsyth.org/pggp/number_of_rrna_operons.htm]). Ribosomal operons in general, including the ISR, are maintained by concerted evolution (2, 4). This correction minimizes replacement by exogenous sequences, so that the operon should closely reflect the evolutionary history of the organism.. We have previously used the ISR for both sequence-based and heteroduplex type-based P. ...
Objective: To investigate the distribution of Prevotella intermedia in subjects with relatively normal periodontal status and to explore the possible transmission of this species among family members. Methods: Dental plaque samples were taken from 61 children and their 120 parents of 60 families. Culture technique was used to determine the presence of black-pigmenting organisms in subgingival and supragingival plaque samples. Identification of Prevotella intermedia was first performed by traditional biochemical tests and then by oligonucleotide probe hybridization. Arbitrarily primed polymerase chain reaction (AP-PCR) was used for clonal analysis of Prevotella intermedia isolated with primer OPA-03. Results: Prevotella intermedia was identified through biochemical tests in 212 bacterial isolates from 95 subjects. Of these 212 isolates from 44 adults and 35 children, 163 were further identified as Prevotella intermedia by DNA hybridization. AP-PCR was performed for the 73 isolated strains of ...
1ZBS: Crystal Structure of the Putative N-acetylglucosamine Kinase (PG1100) from Porphyromonas gingivalis, Northeast Structural Genomics Target PgR18
Forest Smiles - The Best Dentist in Lynchburg, VA Chronic oral infection with the periodontal disease pathogen,Porphyromonas gingivalis, not only causes local
Oral delivery of modified transferrin fusion proteins | Agents that bind a target in pulmonary tissue for targeting respiratory diseases | Cancerous disease modifying antibodies | Dispersion improver for gluten, and dispersion solution of gluten | Porphyromonas gingivalis polypeptides and nucleotides |
Characterisation of a Manganese Transport Regulatory Protein from Porphyromonas gingivalis (Early Career Researcher Grants Scheme) awarded by UNIVERSITY OF MELBOURNE ...
This paper describes a quantitative fluorescent in situ hybridization (FISH) assay for the differential identification of Prevotella intermedia and Prevotella nigrescens in clinical samples, and compares its performance with less discriminatory culture and quantitative immunofluorescence (IF) assays. Fluorescence-labelled oligonucleotide probes directed to specific 16S rRNA sequences of P. intermedia, P. nigrescens, Prevotella pallens and Prevotella denticola were hybridized under stringent conditions with cultured reference strains or plaque samples from deep periodontal pockets. Probe specificity was defined with strains from multiple oral Prevotella species. The lower detection level of the assays was approximately 3x10(3) target cells per ml of plaque-sample suspension. P. intermedia, P. nigrescens, P. pallens and P. denticola were detected in plaques with prevalences of 69, 67, 0 and 28%, respectively. On average, 3.9 x 10(6) P. intermedia, 3.1 x 10(6) P. nigrescens and 5.6 x 10(5) P. ...
RESULTS: 19.5% of plasmablast-derived antibodies from CCP-positive RA patients, but none from the CCP-negative RA patient or healthy controls, specifically recognized citrullinated antigens. The immunoglobulin genes encoding these ACPAs were highly mutated with increased replacement/silent mutation ratios, suggesting the involvement of active antigen selection in ACPA generation. Interestingly, 63% of the ACPAs cross-reacted with OMAs and/or citrullinated enolase from P. gingivalis. The reactivity of ACPAs against citrullinated proteins from P. gingivalis was confirmed by immuno blot and mass spectrometry. Furthermore, germ-line reversions of some ACPAs completely eliminated their reactivity to citrullinated human antigens but retained their reactivity to P. gingivalis ...
Porphyromonas endodontalis ATCC ® 35406D-5™ Designation: Genomic DNA from Porphyromonas endodontalis strain HG 370 TypeStrain=True Application:
Invasion of host cells by S. aureus is likely to play an important role during colonisation and infection. Studies have shown S. aureus invasion to occur via an interaction between its fibronectin binding proteins (FnBPs) and the host integrin a5~J utilising fibronectin (Fn) as a bridging molecule. The reports of S. aureus invasion vary in a number of ways and a number of factors are likely to influence invasion. The aim of this study was to investigate factors involved in determining S. aureus invasion of epithelial cells. The presence of a stable sub-population with enhanced invasive capability has previously been identified for the oral bacterium Porphyromonas gingivalis. In this study consecutive antibiotic protection assays were used in an attempt to determine whether such a sub-population structure exists in S. aureus cultures. Initial findings indicated that S. aureus cultures may contain an invasive sub-population but that this was transient and not stable. This was later attributed to ...
González, Octavio A. et al "HIV-1 Reactivation Induced by the Periodontal Pathogens Fusobacterium nucleatum and Porphyromonas gingivalis Involves Toll-Like Receptor 4 and 9 Activation in Monocytes/Macrophages." Clinical and Vaccine Immunology 17.9 (2010): 1417-1427. Web. 03 June. 2020. ...
Periodontal Disease or Gum Disease is a common condition affecting about 47% of the population and has been present for millennia. Early humans also suffered from this debilitating condition.. There are usually no symptoms like pain despite the fact that the bone and ligaments holding teeth are slowly melting or literally rotting away as part of inflammation.. There are a few known disease causing bacteria that are present in all mouths such as P gingivalis, P Intermedia, and A actinomycetemcomitans. They are responsible for causing Periodontitis in susceptible individuals. Susceptibility to Periodontal Disease is largely genetically determined. In other words, if your parents, grandparents or the family in the ancestral line had Periodontal Disease, you are more likely to get the disease. There are also modifying conditions including habits, emotional stress, medications and diseases which affect Periodontal disease, for example, diet, oral hygiene, smoking, medications such as steroids or ...
The attempt to appreciate, understand and explain raga among European scholars started in the early colonial period.[57] In 1784, Jones translated it as "mode" of European music tradition, but Willard corrected him in 1834 with the statement that a Raga is both mode and tune. In 1933, states José Luiz Martinez - a professor of Music, Stern refined this explanation to "the raga is more fixed than mode, less fixed than the melody, beyond the mode and short of melody, and richer both than a given mode or a given melody; it is mode with added multiple specialities".[57]. A raga is a central concept of Indian music, predominant in its expression, yet the concept has no direct Western translation. According to Walter Kaufmann, though a remarkable and prominent feature of Indian music, a definition of raga cannot be offered in one or two sentences.[4] Raga is a fusion of technical and ideational ideas found in music, and may be roughly described as a musical entity that includes note intonation, ...
This HMM describes a set of proteins related to but longer than DNA-binding protein HU. Its distinctive domain architecture compared to HU and related histone-like DNA-binding proteins justifies the designation as superfamily. Members include, so far, one from Bacteroides fragilis, a gut bacterium, and ten from Porphyromonas gingivalis, an oral anaerobe ...
Dr. Kishore Bhat, Rajiv Gandhi University of Health Sciences, Bangalore.. 05Evaluation of role of pigmented and non-pigmented Prevotella species in patients with chronic periodontics and oral health: A culture based and molecular study. Dr Vijayalakshmi S. Kotrashetti Rajiv Gandhi University of Health Sciences, Bangalore ...
Environmentally concerned schoolchildren join the internationally celebrated Chinmaya Dunster and the Celtic Ragas Band, to read their poems about nature at this CONCERT FOR INDIAS ENVIRONMENTin Pune, India.. ...
Complete 16S rRNA gene sequences of three representative strains of anaerobic, Gram-negative, pigmented, moderately saccharolytic, indole-positive bacteria isolated from the oral cavity of humans were determined. According to comparative analyses of the rRNA sequence data, this organism represents a previously unknown species within the genus Prevotella. In addition, 22 representative strains and 21 reference strains (including 11 Prevotella intermedia and 10 Prevotella nigrescens strains) were subjected to multilocus enzyme electrophoretic analysis. The strains were consistently separated into three clearly distinct groups, corresponding to their previous entities. On the basis of the present phylogenetic results that confirmed our biochemical and genetic data, we propose a new species, Prevotella pallens. The type strain is NCTC 13042 (= AHN 10371).
Nagata, H., Iwasaki, M., Maeda, K., Kuboniwa, M., Hashino, E., Toe, M., … Shizukuishi, S. (2009). Identification of the Binding Domain of Streptococcus oralis Glyceraldehyde-3-Phosphate Dehydrogenase for Porphyromonas gingivalis Major Fimbriae. Infection and Immunity, 77(11), 5130-5138. Kuboniwa, M., Hendrickson, E. L., Xia, Q., Wang, T., Xie, H., Hackett, M., & Lamont, R. J. (2009). Proteomics of Porphyromonas gingivalis within a model oral microbial community. BMC Microbiology, 9, 98.. Gambone, J. E., Dusaban, S. S., Loperena, R., Nakata, Y., & Shetzline, S. E. (2011). The c-Myb target gene neuromedin U functions as a novel cofactor during the early stages of erythropoiesis. Blood, 117(21), 5733-5743.. To see more references related to this product click here. ...
Periodontitis is a chronic inflammatory disease that leads to destruction of tooth supporting tissues. Porphyromonas gingivalis (P. gingivalis), especially its lipopolysaccharides (LPS), is one of major pathogens that cause periodontitis. Bee venom (BV) has been widely used as a traditional medicine for various diseases. Previous studies have demonstrated the anti-inflammatory, anti-bacterial effects of BV. However, a direct role and cellular mechanism of BV on periodontitis-like human keratinocytes have not been explored. Therefore, we investigated the anti-inflammatory mechanism of BV against P. gingivalis LPS (PgLPS)-induced HaCaT human keratinocyte cell line. The anti-inflammatory effect of BV was demonstrated by various molecular biological methods. The results showed that PgLPS increased the expression of Toll-like receptor (TLR)-4 and pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, IL-8, and interferon (IFN)-γ. In addition, PgLPS induced ...
Periodontitis is a chronic inflammatory disease that leads to destruction of tooth supporting tissues. Porphyromonas gingivalis (P. gingivalis), especially its lipopolysaccharides (LPS), is one of major pathogens that cause periodontitis. Bee venom (BV) has been widely used as a traditional medicine for various diseases. Previous studies have demonstrated the anti-inflammatory, anti-bacterial effects of BV. However, a direct role and cellular mechanism of BV on periodontitis-like human keratinocytes have not been explored. Therefore, we investigated the anti-inflammatory mechanism of BV against P. gingivalis LPS (PgLPS)-induced HaCaT human keratinocyte cell line. The anti-inflammatory effect of BV was demonstrated by various molecular biological methods. The results showed that PgLPS increased the expression of Toll-like receptor (TLR)-4 and pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, IL-8, and interferon (IFN)-γ. In addition, PgLPS induced ...
Periodontitis is a chronic inflammatory disease that leads to destruction of tooth supporting tissues. Porphyromonas gingivalis (P. gingivalis), especially its lipopolysaccharides (LPS), is one of major pathogens that cause periodontitis. Bee venom (BV) has been widely used as a traditional medicine for various diseases. Previous studies have demonstrated the anti-inflammatory, anti-bacterial effects of BV. However, a direct role and cellular mechanism of BV on periodontitis-like human keratinocytes have not been explored. Therefore, we investigated the anti-inflammatory mechanism of BV against P. gingivalis LPS (PgLPS)-induced HaCaT human keratinocyte cell line. The anti-inflammatory effect of BV was demonstrated by various molecular biological methods. The results showed that PgLPS increased the expression of Toll-like receptor (TLR)-4 and pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, IL-8, and interferon (IFN)-γ. In addition, PgLPS induced ...
Periodontitis is a chronic inflammatory disease that leads to destruction of tooth supporting tissues. Porphyromonas gingivalis (P. gingivalis), especially its lipopolysaccharides (LPS), is one of major pathogens that cause periodontitis. Bee venom (BV) has been widely used as a traditional medicine for various diseases. Previous studies have demonstrated the anti-inflammatory, anti-bacterial effects of BV. However, a direct role and cellular mechanism of BV on periodontitis-like human keratinocytes have not been explored. Therefore, we investigated the anti-inflammatory mechanism of BV against P. gingivalis LPS (PgLPS)-induced HaCaT human keratinocyte cell line. The anti-inflammatory effect of BV was demonstrated by various molecular biological methods. The results showed that PgLPS increased the expression of Toll-like receptor (TLR)-4 and pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, IL-8, and interferon (IFN)-γ. In addition, PgLPS induced ...
Silver, Fusobacterium, Fusobacterium Nucleatum, Ability, Copper, Nanoparticles, Oxygen, Mothers, Oral Cavity, Porphyromonas, Porphyromonas Gingivalis, Pregnancy, Strains, Lead, Titanium, Tungsten, Concentrations, Electron, Electron Microscopy, Elements
Analysis of post-mortem with and without dementia has found lipopolysaccharide, a component of an oral bacterium (Porphyromonas gingivalis), in four out of 10 Alzheimers disease brain samples, but not in any of the 10 brains of people who didnt have Alzheimers.. Gingivitis is extremely common, and about 64% of American seniors (65+) have moderate or severe periodontal disease.. The finding adds to evidence linking gum disease and Alzheimers.. http://www.futurity.org/alzheimers-may-ties-gum-disease/. ...
Dashper, S. G. et al "Characterization of a Novel Outer Membrane Hemin-Binding Protein of Porphyromonas gingivalis ." Journal of Bacteriology 182.22 (2000): 6456-6462. Web. 20 Nov. 2019. ...
Poor dental health and gum disease may be linked to Alzheimers disease, a study suggests. Brains of deceased dementia patients were found to contain signs of Porphyromonas gingivalis, the bug respons...
Production of recombinant proteins in transgenic plants and hairy roots. Development of plant-based vaccines for the delivering of antigens from distinct human pathogens (Neisseria gonorrhea, Porphyromonas gingivalis, and Yersinia pestis) to the human mucosa. Plant Pathology, Physiology, and Weed Science Department. Virginia Polytechnic Institute and State University. Blacksburg, Virginia, USA ...
No significant differences were detected at baseline in proportions of flora of target Table 4a. Mean values, standard error (SE) and 95% confidence intervals (CI) of log of colony- forming units at study visits and intra-group comparison (ANOVA and multiple rank test) were also detected, specifically thoserelated with P. gingivalis. Conversely, 7.18 0.15 6.88 7.47 po0.066, baseline 7.07 0.16 6.75 7.40 p 5 0.511, relevant limitations. Only 15 patients in placebo group provided data for 6-monthvisit, and this may be considered as a Table 4b. Mean values, standard error (SE) and 95% confidence intervals (CI) of changes in log of colony-forming units between visits and inter-group comparison (ANCOVA, with treatment as factor and baseline value as cofactors; significant cofactors are listed) ences in size between both groups. Also,the effect of smoking in the results could control this variable was made by strati- failed to find significant differences in periodontal disease severity ...
TY - JOUR. T1 - Infection by Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans, and antibody responses at different ages in humans.. AU - Nakagawa, S.. AU - Machida, Y.. AU - Nakagawa, Taneaki. AU - Fujii, H.. AU - Yamada, S.. AU - Takazoe, I.. AU - Okuda, K.. PY - 1994/1. Y1 - 1994/1. N2 - This study examined the serum IgG and IgM responses against Porphyromonas gingivalis and 3 serotypes of Actinobacillus actinomycetemcomitans, and the correlations of these responses with age and homologous infection. A total of 90 individuals were included in this study: 40 subjects with gingivitis, 40 periodontally healthy subjects, and 10 adult periodontitis subjects. The subjects in the gingivitis and periodontally healthy groups were divided into 4 stages based on their physiological age: early childhood, school age, puberty, and adult. In the gingivitis group, there was a positive correlation between increase in age and increase in serum IgG antibody levels against P. gingivalis until ...
Hamster Gingival Epithelial Cells from Creative Bioarray are isolated from gingival tissue of pathogen-free laboratory mice. Hamster Gingival Epithelial Cells are grown in a T25 tissue culture flask pre-coated with gelatin-based coating solution for 2 min and incubated in Creative Bioarrays Culture Complete Growth Medium for 3-5 days. Cells are detached from flasks and immediately cryo-preserved in vials. Each vial contains at least 0.5x10^6 cells per ml and is delivered frozen. Cells can be expanded for 3-7 passages at a split ratio of 1:2 under the cell culture conditions specified by Creative Bioarray. Repeated freezing and thawing of cells is not recommended ...
Porphyromonas gingivalis is the foremost oral pathogen of adult periodontitis in humans. However, the mechanisms of bacterial invasion and the resultant destruction of the gingival tissue remain largely undefined. We report host-P. gingivalis interactions in primary human gingival fibroblast (HGF) cells. Quantitative immunostaining revealed the need for a high multiplicity of infection for optimal infection. Early in infection (2-12 h), P. gingivalis activated the proinflammatory transcription factor NF-kappa B, partly via the PI3 kinase/AKT pathway. This was accompanied by the induction of cellular anti-apoptotic genes, including Bfl-1, Boo, Bcl-XL, Bcl2, Mcl-1, Bcl-w and Survivin. Late in infection (24-36 h) the anti-apoptotic genes largely shut down and the pro-apoptotic genes, including Nip3, Hrk, Bak, Bik, Bok, Bax, Bad, Bim and Moap-1, were activated. Apoptosis was characterized by nuclear DNA degradation and activation of caspases-3, -6, -7 and -9 via the intrinsic mitochondrial pathway. Use of
Porphyromonas gingivalis is the foremost oral pathogen of adult periodontitis in humans. However, the mechanisms of bacterial invasion and the resultant destruction of the gingival tissue remain largely undefined. We report host-P. gingivalis interactions in primary human gingival fibroblast (HGF) cells. Quantitative immunostaining revealed the need for a high multiplicity of infection for optimal infection. Early in infection (2-12 h), P. gingivalis activated the proinflammatory transcription factor NF-kappa B, partly via the PI3 kinase/AKT pathway. This was accompanied by the induction of cellular anti-apoptotic genes, including Bfl-1, Boo, Bcl-XL, Bcl2, Mcl-1, Bcl-w and Survivin. Late in infection (24-36 h) the anti-apoptotic genes largely shut down and the pro-apoptotic genes, including Nip3, Hrk, Bak, Bik, Bok, Bax, Bad, Bim and Moap-1, were activated. Apoptosis was characterized by nuclear DNA degradation and activation of caspases-3, -6, -7 and -9 via the intrinsic mitochondrial pathway. Use of
In an article titled Periodontal Assessments of Postmenopausal Women Receiving Risedronate, a graduate of the Case Western Reserve University School of Dental Medicine, reports that drugs that are used to combat
Özlem Güçlü Üstündag, Sevcan Ersan, Ezgi Özcan, Gizem Özan, Neslihan Kayra, F. Yesim Ekinci. Black tea processing waste as a source of antioxidant and antimicrobial phenolic compounds. European Food Research and Technology, Volume: 242 Issue: 9 Pages: 1523-1532 Published: SEP 2016.. F.Y. Ekinci, G.M. Baser, E. Özcan, Ö. Güçlü-Üstündağ, M. Korachi, A. Sofu, J.B. Blumberg, C-Y O Chen. Characterization of Chemical, Biological and Antiproliferative Properties of Fermented Black Carrot Juice, Shalgam. European Food Research and Technology, Volume: 242 Issue: 8 Pages: 1355-1368 Published: AUG 2016.. Sofu and F.Y. Ekinci. 2016. Bacterial diversity dynamics of traditional Turkish ezine cheese as evaluated by PCR-DGGE and SSCP analysis. International Journal of Dairy Technology Volume: 69 Issue: 4 Pages: 592-600 Published: NOV 2016.. Aydın, F.Y. Ekinci, M. Korachi. Expression profiles of TGF-β and TLR pathways in Porphyromonas gingivalis and Prevotella intermedia challenged osteoblasts. ...
Affiliation:日本歯科大学,生命歯学部,教授, Research Field:Morphological basic dentistry,Morphological basic dentistry,Bacteriology (including Mycology),Social dentistry, Keywords:シアル酸,Streptococcus gordonii,口腔レンサ球菌,遺伝子クローニング,DPPIV,感染症,Porphyromonas gingivalis,感染性心内膜炎,dipeptidyl aminopeptidase IV,virulence, # of Research Projects:8, # of Research Products:34, Ongoing Project:免疫抑制剤服用小児における歯肉増殖症の発症メカニズムの解明と予防プロトコルの確立
TY - JOUR. T1 - Relationship of periodontal infection to serum antibody levels to periodontopathic bacteria and inflammatory markers in periodontitis patients with coronary heart disease. AU - Yamazaki, K.. AU - Honda, T.. AU - Domon, H.. AU - Okui, T.. AU - Kajita, K.. AU - Amanuma, R.. AU - Kudoh, C.. AU - Takashiba, S.. AU - Kokeguchi, S.. AU - Nishimura, F.. AU - Kodama, M.. AU - Aizawa, Y.. AU - Oda, H.. PY - 2007/9/1. Y1 - 2007/9/1. N2 - Several reports have demonstrated a possible association of periodontal infections with coronary heart disease (CHD) by elevated antibody titre to periodontopathic bacteria in CHD patients compared with non-diseased controls. Although each periodontopathic bacterium may vary in virulence for periodontitis and atherosclerosis, antibody response to multiple bacteria in CHD patients has not been understood fully. Therefore, serum levels of antibody to 12 periodontopathic bacteria together with other atherosclerotic risk markers were compared among 51 patients ...
Coloured scanning electron micrograph (SEM) of Prevotella intermedia, Gram-negative, anaerobic, rod shaped, prokaryote (bacterium). Prevotella intermedia is a black pigmented bacterium that was formerly known as Bacteroides intermedius or Bacteroides melaninogenicus. It can coaggregate with other Gram-positive oral bacteria such as Porphyromonas gingivalis and Actinomyces viscosus. P. intermedia is a normal part of the oral and vaginal flora but can cause respiratory infections including aspiration pneumonia, lung abscesses and osteomyelitis. It can also cause gingivitis and other types of oral lesions including vertical bone loss. P. intermedia, along with Porphyromonas gingivalis, are known to cause polymicrobial infections. Prevotella sp. often become resistant to antibiotics, especially tetracycline and penicillin. Magnification: x3,400 when shortest axis printed at 25 millimetres. - Stock Image C032/2243
C57BL/6-GFP Mouse Gingival Epithelial Cells from Creative Bioarray are isolated from C57BL/6-GFP-Tg(CAG-EGFP)1Osb/J mouse gingival tissue of pathogen-free laboratory mice. C57BL/6-GFP Mouse Gingival Epithelial Cells are grown in a T25 tissue culture flask pre-coated with gelatin-based coating solution for 2 min and incubated in Creative Bioarrays Culture Complete Growth Medium for 3-5 days. Cells are detached from flasks and immediately cryo-preserved in vials. Each vial contains at least 0.5x10^6 cells per ml and is delivered frozen. These cells are pre-coated with EpCAM-1 (CD326) antibody, following the application of magnetic beads pre-coated with secondary antibody Cells can be expanded for 3-7 passages at a split ratio of 1:2 under the cell culture conditions specified by Creative Bioarray. Repeated freezing and thawing of cells is not recommended ...
Affiliation:九州大学,大学病院,研究員, Research Field:Morphological basic dentistry,Dental engineering/Regenerative dentistry,Periodontal dentistry,Social dentistry,Periodontology, Keywords:歯周病原細菌,Porphyromonas gingivalis,歯周炎,総頸動脈内膜中膜複合体,慢性辺縁性歯周炎,高次構造,安定型高次構造リポ多糖,歯周病,バイオフィルム,Tannerella forsythensis, # of Research Projects:5, # of Research Products:15, Ongoing Project:非熱的不可逆エレクトロポレーションによるインプラント周囲炎の低侵襲治療法
C. nigrescens - spores mult-septate, , 50µm long. I know C. nigrescens is supposed to have a fibrous medulla (as shown here), and it is supposed to be a widespread and common species throughout eastern North America (along with the sometimes apparently very similar C. pulcellum). I dont know much about the other two. Some sources claim C. ryssoleum is saxicolous (B. Ryans unpublished keys). And C. leptaleum seems to mostly be a southern thing (so therefore presumably uncommon in the Smokies, one presumes).. Lets just assume the spores I saw were immature and stay with C. nigrescens! :) ...
(2005) Young et al. Tissue Engineering. Tooth loss accompanied by alveolar bone resorption presents a significant clinical problem. We have investigated the utility of a tissue-engineering approach to provide corrective therapies for too...
A total 12 million Germans suffer from periodontitis. If the inflammation remains untreated, this could lead to tooth loss. However, it is also suspected of triggering many other diseases, like cardiopulmonary diseases. Researchers are studying the interactions, and developing compounds to combat the causative agents.
Lineage: cellular organisms; Bacteria; FCB group; Bacteroidetes/Chlorobi group; Bacteroidetes; Bacteroidia; Bacteroidales; Porphyromonadaceae; Porphyromonas; Porphyromonas ...
Profile of Dr. Uttam Singh Tolia, Physiotherapist in Haldwani: Get complete information about Dr. Uttam Singh Tolia BPT practicing at Raga Physiotherapy Clinic, his specialities, expertise with complete address, appointment phone numbers, timings, awards and associated hospital information | Sehat
Particularly suited for treatment of smaller defects and periodontal bone defects. Can be cut to shape and size in dry or wet conditions. Does not stick to itself and to instruments. Can be easily repositioned, if needed. Exceptional adaptability to surface contour after rehydration.. ...
Abstrak: Cardiovascular diseases (CVD) masih merupakan penyebab kematian dan disabilitas utama di negara berkembang dibandingkan penyakit lainnya. Selama beberapa dasawarsa CVD dianggap sebagai penyakit degeneratif yang dipengaruhi faktor genetik dan gaya hidup, termasuk merokok, kurangnya olah raga serta obesitas. Studi terbaru dari Baker dan kawan-kawan, mendemonstrasi adanya hubungan antara berat badan lahir dengan mortalitas kardiovaskular. Pertumbuhan janin terhambat merupakan faktor risiko CVD pada usia dewasa. ...
Jika Anda merekam olah raga, nilai harian HR menunjukkan kenaikan detak jantung dan konsumsi kalori dari latihan Anda. Tapi ingat bahwa grafik dan tingkat konsumsi hanyalah rata-rata. Jika puncak detak jantung Anda adalah 200 bpm saat berolahraga, grafik tersebut tidak memperlihatkan nilai maksimum melainkan rata-rata dari 24 menit saat Anda mencapai nilai puncak itu.. Sebelum dapat melihat tampilan HR harian, Anda harus mengaktifkan fitur HR harian. Anda dapat mengaktifkan atau menonaktifkan fitur ini dari pengaturan di bawah Activity (Aktivitas). Jika berada dalam tampilan pemantauan aktivitas, Anda juga dapat mengakses pengaturan aktivitas dengan terus menekan tombol tengah.. Saat fitur HR harian aktif, arloji Anda mengaktifkan sensor optik detak jantung secara rutin untuk memeriksa detak jantung Anda. Tindakan ini sedikit menambah konsumsi daya baterai.. ...
Material and methods/results The authors used organ cultured neonatal mouse calvarial bones and isolated periosteal osteoblasts which express TLRs to study the role of TLR2 in bone resorption. LPS from the perio-pathogenic bacterium Porphyromonas gingivalis (Pg; which is a weak agonist for TLR4 but a strong for TLR2 because of the contaminating lipoprotein), enhanced number of osteoclasts, 45Ca release and bone matrix degradation (CTX) by a process inhibited by osteoprotegerin and zolendronic acid. LPS Pg enhanced the expression of osteoclastic genes (c-Fos, trap, oscar and cathepsin K) and reduced the expression of osteoblastic genes (osteocalcin, runx2, alp and procollagen α1). The effects were associated with increased mRNA and protein expression of RANKL, whereas OPG mRNA and protein were unaffected. Similar to LPS Pg, Pam2CSK4 (synthetic ligand for TLR2/TLR6), Pam3CSK4 (ligand for TLR1/TLR2), HKLM (a heat killed preparation of Listeria monocytogenes, a TLR2 agonist) and FSL1 (a synthetic ...
High prevalences were observed for Fusobacterium nucleatum, Prevotella intermedia and Porphyromonas gingivalis in tongue coating, saliva and subgingival plaque samples. A significant positive correlation between baseline total counts of P. gingivalis in saliva samples and organoleptic and VSC scores was found. Two weeks post-treatment there was a reduction in total anaerobic counts in all samples in the test group. A significant positive correlation was observed between the reduction in total counts in saliva samples and the reduction in organoleptic scores in the test group ...
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
p,This large-scale study cross-sectionally examined the periodontal status and prevalence of "red complex" bacteria (,i,Porphyromonas gingivalis,/i,, ,i,Treponema denticola,/i,, and ,i,Tannerella forsythia,/i,) in Japanese adults. A total of 977 participants were enrolled in the study. Probing depth (PD), bleeding on probing (BOP), and bone crest level (BCL) were recorded, and the presence of red complex bacteria in the saliva was examined using polymerase chain reaction. The mean BCL value and the percentage of sites with a PD ≥4 mm or the presence of BOP were significantly higher in older participants. The detection rates of ,i,P. gingivalis,/i,, ,i,T. denticola,/i,, and ,i,T. forsythia,/i, were 46.3%, 76.4%, and 61.1%, respectively. The ,i,P. ,i,gingivalis,/i, detection rate significantly increased with age, while those of ,i,T. denticola,/i, and ,i,T. forsythia,/i, were comparably high for all age groups. A close correlation between ,i,P. gingivalis,/i, and the percentage of sites with PD ...
Periodontal disease is a condition in which the gums and bones surrounding the teeth are inflamed. It is a common cause of oral discomfort and tooth loss, but in recent years has been linked to a variety of systemic problems. Among them is cardiovascular disease, which is the top cause of death in the developed world. There is evidence that periodontal pathogens invade the bloodstream from the gingival pockets and contribute to the progression of disease through a variety of different mechanisms. First, they initiate the systemic inflammatory process by invading and activating vascular endothelial cells to upregulate adhesion molecules and chemokines, which then in turn activate macrophages to take up low density lipoprotein and deposit it on the luminal wall. Atherosclerotic plaque is pro-thrombotic, which increases the chances of forming blood clots and ischemic attacks. Periodontal pathogens also can induce the proliferation of antibodies that can cross-react with self-antigens, resulting in ...

Advanced Search Results - Public Health Image Library(PHIL)Advanced Search Results - Public Health Image Library(PHIL)

Categories: Bacteroidaceae Infections Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, ...
more infohttps://phil.cdc.gov/AdvancedSearchResults.aspx?Search=Bacteroidaceae+Infections&parentid=30954&catid=30886

RIPK2 levels are stable in HAEC stimulated with TLR or  | Open-iRIPK2 levels are stable in HAEC stimulated with TLR or | Open-i

Bacteroidaceae Infections/metabolism*. *Endothelial Cells/metabolism*/microbiology. *Porphyromonas gingivalis/metabolism*/ ... In this study, we demonstrate that P. gingivalis infection of HAEC resulted in the rapid cleavage of receptor interacting ... In this study, we demonstrate that P. gingivalis infection of HAEC resulted in the rapid cleavage of receptor interacting ...
more infohttps://openi.nlm.nih.gov/detailedresult.php?img=PMC3369954_ppat.1002723.g003&req=4

CATSCLEM GEZONDHEID en ZIEKTE   -   HEALTH and DISEASECATSCLEM GEZONDHEID en ZIEKTE - HEALTH and DISEASE

Zie ook: URINARY TRACT INFECTIONS. BACTEROIDACEAE INFECTIONS. Zie ook: BACTERI LE INFECTIES BACTERIAL INFECTIONS. Zie ook: GRAM ... BACILLACEAE INFECTIONS. Zie ook: BACTERI LE INFECTIES BACTERIAL INFECTIONS. Zie ook: GRAM-POSITIVE BACTERIAL INFECTIONS. Zie ... Zie ook: INFECTIES INFECTIONS. Zie ook: INFECTIOUS SKIN DISEASES. Zie ook: BACTERI LE INFECTIES BACTERIAL INFECTIONS. Zie ook: ... Zie ook: BACTERI LE INFECTIES BACTERIAL INFECTIONS. Zie ook: GRAM-NEGATIVE BACTERIAL INFECTIONS. Zie ook: BRUCELLA. Zie ook: ...
more infohttp://www.catsclem.nl/medisch/medbad.htm

NAVER 학술정보 >...NAVER 학술정보 >...

Antibiosis, Bacterial Proteins, genetics, metabolism, Bacteroidaceae Infections, microbiology, Biofilms, growth & development, ...
more infohttps://academic.naver.com/search.naver?field=3&query=Journal+of+Bacteriology+182%EA%B6%8C+24%ED%98%B8

List of MeSH codes (C01) - WikipediaList of MeSH codes (C01) - Wikipedia

... bacteroidaceae infections MeSH C01.252.400.110.109 --- bacteroides infections MeSH C01.252.400.126 --- bartonellaceae ... acinetobacter infections MeSH C01.252.400.610 --- mycoplasmatales infections MeSH C01.252.400.610.610 --- mycoplasma infections ... bordetella infections MeSH C01.252.400.143.740 --- whooping cough MeSH C01.252.400.155 --- borrelia infections MeSH C01.252. ... proteus infections MeSH C01.252.400.310.821 --- salmonella infections MeSH C01.252.400.310.821.438 --- paratyphoid fever MeSH ...
more infohttps://en.wikipedia.org/wiki/List_of_MeSH_codes_(C01)

Diagnostic evaluation of a nanobody with picomolar affinity toward the protease RgpB from Porphyromonas gingivalis.  - PubMed -...Diagnostic evaluation of a nanobody with picomolar affinity toward the protease RgpB from Porphyromonas gingivalis. - PubMed -...

Bacteroidaceae Infections/diagnosis*. *Bacteroidaceae Infections/microbiology. *Biomarkers/metabolism. *Cysteine Endopeptidases ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/21569755

Antibodies to Porphyromonas gingivalis Indicate Interaction Between Oral Infection, Smoking, and Risk Genes in Rheumatoid...Antibodies to Porphyromonas gingivalis Indicate Interaction Between Oral Infection, Smoking, and Risk Genes in Rheumatoid...

... study suggests that the previously reported link between periodontitis and RA could be accounted for by P gingivalis infection ... Humans, Porphyromonas gingivalis, Bacteroidaceae Infections, Arthritis, Rheumatoid, Periodontitis, Autoimmune Diseases, ... Antibodies to Porphyromonas gingivalis Indicate Interaction Between Oral Infection, Smoking, and Risk Genes in Rheumatoid ... Antibodies to Porphyromonas gingivalis Indicate Interaction Between Oral Infection, Smoking, and Risk Genes in Rheumatoid ...
more infohttps://www.ndorms.ox.ac.uk/publications/586500

Porphyromonas gingivalis bacteremia induces coronary and aortic atherosclerosis in normocholesterolemic and...Porphyromonas gingivalis bacteremia induces coronary and aortic atherosclerosis in normocholesterolemic and...

Bacteroidaceae Infections/complications*. *Bacteroidaceae Infections/pathology. *Carotid Artery Diseases/microbiology. *Carotid ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/15845905

What does bacteroides fragilis mean?What does bacteroides fragilis mean?

B. fragilis group is the most commonly isolated Bacteroidaceae in anaerobic infections, especially those that originate from ... The B. fragilis group is the species of Bacteroidaceae isolated with greatest frequency in clinical specimens. These organisms ... It is the most common species of anaerobic bacteria isolated from human soft tissue infections. ...
more infohttps://www.definitions.net/definition/bacteroides%20fragilis

Bacteroides fragilis - WikipediaBacteroides fragilis - Wikipedia

The B. fragilis group is the most commonly isolated Bacteroidaceae in anaerobic infections, especially those that originate ... It is part of the normal flora of the human colon and is generally commensal, but can cause infection if displaced into the ... Bacteroides infections at eMedicine Brook I (June 2010). "The role of anaerobic bacteria in bacteremia". Anaerobe. 16 (3): 183- ... ISBN 0-443-06643-4. Brook I (December 2007). "Treatment of anaerobic infection". Expert Rev Anti Infect Ther. 5 (6): 991-1006. ...
more infohttps://en.wikipedia.org/wiki/Bacteroides_fragilis

The female urinary microbiome in urgency urinary incontinence.  - PubMed - NCBIThe female urinary microbiome in urgency urinary incontinence. - PubMed - NCBI

Bacteroidaceae Infections/epidemiology. *Bacteroidaceae Infections/microbiology*. *Body Mass Index. *Botulinum Toxins, Type A/ ... DNA sequencing confirmed urinary bacterial DNA in many women with urgency urinary incontinence who had no signs of infection. ... Associations with demographics, urinary symptoms, urinary tract infection risk, and treatment outcomes were determined. In ... and were less likely to experience urinary tract infection (9% vs 27%; P = .0011). In sequence-positive samples, 8 major ...
more infohttps://phgkb.cdc.gov/PHGKB/phgHome.action?action=forward&dbsource=amd&id=3413

The rectal mucosa and condomless receptive anal intercourse in HIV-negative MSM: implications for HIV transmission and...The rectal mucosa and condomless receptive anal intercourse in HIV-negative MSM: implications for HIV transmission and...

Bacteroidaceae Infections/immunology*. *CD8-Positive T-Lymphocytes/immunology*. *Cell Proliferation. *Condoms/statistics & ... Most HIV transmissions among men who have sex with men (MSM), the group that accounted for 67% of new US infections in 2014, ...
more infohttps://phgkb.cdc.gov/PHGKB/phgHome.action?action=forward&dbsource=cdcpub&id=3669

Search Articles | University of Toronto LibrariesSearch Articles | University of Toronto Libraries

Bacteroidaceae Infections - microbiology , Survival Analysis , Dental Implants , Gram-Negative Bacteria - classification , ... YEAST , INFECTIONS , SPECIFICITY , BACILLUS-SUBTILIS , ANNOTATION , BIOCHEMISTRY & MOLECULAR BIOLOGY , GENES , REGULATORS , ... CANDIDA-ALBICANS , MULTIDISCIPLINARY SCIENCES , DISEASE , ORAL MICROBIOME , INFECTION , HEALTH , IMMUNE RECOGNITION , Dentures ... Microbiology , Bacteria , Implant dentures , Pathology , Bacterial infections , Dentistry , Transplants & implants , Teeth , ...
more infohttps://query.library.utoronto.ca/index.php/search/q?kw=SubjectTerms:Dentures%20-%20microbiology

Search Articles | University of Toronto LibrariesSearch Articles | University of Toronto Libraries

Bacteroidaceae Infections - blood , Bacteroidaceae Infections - immunology , Adult , Environment , Female , Arthritis, ... Bacteroidaceae Infections - complications , Prospective Studies , Arthritis, Rheumatoid - blood , Comorbidity , Antibodies, ... Rituximab , TNF blocker , Systemic lupus erythematosus , Registry , Abatacept , Rheumatoid arthritis , INFECTIONS , ... Objective To investigate the possible link between Porphyromonas gingivalis infection and rheumatoid arthritis (RA), according ...
more infohttps://query.library.utoronto.ca/index.php/search/q?kw=Author:Gottenberg,%20Jacques%E2%80%90Eric

Frontiers | Mycotoxin: Its Impact on Gut Health and Microbiota | Cellular and Infection MicrobiologyFrontiers | Mycotoxin: Its Impact on Gut Health and Microbiota | Cellular and Infection Microbiology

The authors also reported that the relative abundance of Lactobacillaceae was increased whereas the Bacteroidaceae was ... Apart from that, the gut microbiota protects the host against infections via several mechanisms. The microbes reside in the gut ... recruited to infection sites, thus leading to the ineffective elimination of pathogen from the gut (Brazil et al., 2013). ... OTA-treated animals experienced faster and more harmful parasite infections (provoked by Eimeria acervulina and E. adenoeides) ...
more infohttps://www.frontiersin.org/articles/10.3389/fcimb.2018.00060/full

Frontiers | FAM96A Protects Mice From Dextran Sulfate Sodium (DSS)-Induced Colitis by Preventing Microbial Dysbiosis | Cellular...Frontiers | FAM96A Protects Mice From Dextran Sulfate Sodium (DSS)-Induced Colitis by Preventing Microbial Dysbiosis | Cellular...

J) Relative abundance of the families Alcaligenaceae, Bacteroidaceae, Bifidobacteriaceae, Clostridiales_vadinBB60_group, ... and Infection Microbiology Microbiome in Health and Disease Toggle navigation Section * (current)Section ... and Porphyromonadaceae and reduced relative abundance of Bacteroidaceae, Clostridiales_vadinBB60_group, ratAN060301C, ...
more infohttps://www.frontiersin.org/articles/10.3389/fcimb.2019.00381/full

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Target identification in Fusobacterium nucleatum by subtractive genomics approach and enrichment analysis of host-pathogen...Target identification in Fusobacterium nucleatum by subtractive genomics approach and enrichment analysis of host-pathogen...

Fusobacterium nucleatum is a gram-negative, anaerobic opportunistic pathogen from bacteroidaceae family that causes infection ... nucleatum infection (Fig. 3). Host epithelial cells detect F. nucleatum infection via TLRs [52]. Infection by this bacterium ... nucleatum infection to host immune responses [11, 53-55]. F. nucleatum infection inhibits T-cell activation by preventing cells ... In the current work, we investigated HP-PPIs of F. nucleatum with respect to its infection in IBD and CRC. The RefSeq proteome ...
more infohttps://0-bmcmicrobiol-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/s12866-016-0700-0

Pseudomonas Infections | Harvard Catalyst Profiles | Harvard CatalystPseudomonas Infections | Harvard Catalyst Profiles | Harvard Catalyst

Gram-Negative Bacterial Infections. *Aliivibrio Infections. *Anaplasmataceae Infections. *Bacteroidaceae Infections. * ... "Pseudomonas Infections" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... This graph shows the total number of publications written about "Pseudomonas Infections" by people in Harvard Catalyst Profiles ... Below are MeSH descriptors whose meaning is related to "Pseudomonas Infections".. * ...
more infohttps://connects.catalyst.harvard.edu/Profiles/display/Concept/Pseudomonas%20Infections

Enterobacteriaceae Infections | Harvard Catalyst Profiles | Harvard CatalystEnterobacteriaceae Infections | Harvard Catalyst Profiles | Harvard Catalyst

Gram-Negative Bacterial Infections. *Aliivibrio Infections. *Anaplasmataceae Infections. *Bacteroidaceae Infections. * ... "Enterobacteriaceae Infections" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ... This graph shows the total number of publications written about "Enterobacteriaceae Infections" by people in Harvard Catalyst ... Multicenter Study of the Risk Factors for Colonization or Infection with Carbapenem-Resistant Enterobacteriaceae in Children. ...
more infohttps://connects.catalyst.harvard.edu/Profiles/display/Concept/Enterobacteriaceae%20Infections

The fecal resistome of dairy cattle is associated with diet during nursing | Nature CommunicationsThe fecal resistome of dairy cattle is associated with diet during nursing | Nature Communications

Bolan, G. A., Sparling, P. F. & Wasserheit, J. N. The emerging threat of untreatable gonococcal infection. New Engl. J. Med. ... Diet may also represent an indirect influence on the resistome by enriching certain taxa, such as Bacteroidaceae, in the gut ... In contrast, tetracycline ARGs, including the highly abundant tetQ, were predicted to originate in Bacteroidaceae. While no ... Intriguingly, the species within Bacteroidaceae were shown to harbor tetQ and other tetracycline resistance genes, suggesting a ...
more infohttps://www.nature.com/articles/s41467-019-12111-x?error=cookies_not_supported&code=11c3023a-722c-4551-bbd1-f96c740341a4

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Treatment of skin disease, soft tissue infections, dental infections, urinary tract infections, respiratory disease and ... bacteroidaceae, Fusobacterium necrophorum, Clostridium perfringens and osteomyelitis caused by Staphylococcus aureus. ... Treatment of skin disease, soft tissue infections, dental infections, urinary tract infections, respiratory disease and ... For treatment of infected wounds, abscesses, oral cavity/dental infections: *Administer 5.5 mg/kg bodyweight every 12 hours for ...
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Treatment of mixed infections by immature and adult cestodes (tapeworms) and nematodes (roundworms) in cats / milbemycin oxime ... bacteroidaceae, Fusobacterium necrophorum, Clostridium perfringens and osteomyelitis caused by Staphylococcus aureus. ... Treatment of mixed infections by immature and adult cestodes (tapeworms) and nematodes (roundworms) in cats / milbemycin oxime ... For treatment of infected wounds, abscesses, oral cavity/dental infections: *Administer 5.5 mg/kg bodyweight every 12 hours for ...
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Bacterial InfectionsBacterial Infections

Necrotizing Soft Tissue Infection, Group A Streptococcal Cellulitis, Non-Group A Streptococcal Cellulitis, Vibrio Cellulitis, ... Erythrasma, Gram-Negative Toe Web Infection, Impetigo, Bullous Impetigo, Staphylococcal Scalded Skin Syndrome. ... Bacterial Infections is a chapter in the book, Dermatology, containing the following 14 pages: Cellulitis, Aeromonas Hydrophila ... Actinomycetes Actinomycosis Aerobic Gram Negative Rod Anthrax Bacteria Bacteroidaceae Bartonella Brucellosis Chlamydiae ...
more infohttp://www.fpnotebook.com/Derm/Bacteria/index.htm
  • Malattia Da Graffio Di Gatto 0 domande A self-limiting bacterial infection of the regional lymph nodes caused by AFIPIA felis, a gram-negative bacterium recently identified by the Centers for Disease Control and Prevention and by BARTONELLA HENSELAE. (lookformedical.com)
  • In this study, we demonstrate that P. gingivalis infection of HAEC resulted in the rapid cleavage of receptor interacting protein 1 (RIPK1), a mediator of tumor necrosis factor (TNF) receptor-1 (TNF-R1)-induced cell activation or death, and RIPK2, a key mediator of both innate immune signaling and adaptive immunity. (nih.gov)
  • Pseudomonas Infections" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • It is part of the normal flora of the human colon and is generally commensal, but can cause infection if displaced into the bloodstream or surrounding tissue following surgery, disease, or trauma. (wikipedia.org)
  • Fournier gangrene is usually secondary to perirectal or periurethral infections associated with local trauma, operative procedures, or urinary tract disease. (lookformedical.com)
  • Most HIV transmissions among men who have sex with men (MSM), the group that accounted for 67% of new US infections in 2014, occur via exposure to the rectal mucosa. (cdc.gov)