A family of gram-negative bacteria found primarily in the intestinal tracts and mucous membranes of warm-blooded animals. Its organisms are sometimes pathogenic.
A genus of gram-negative, anaerobic, rod-shaped bacteria found in cavities of humans and other animals. No endospores are formed. Some species are pathogenic and occur in various purulent or gangrenous infections.
Infections with bacteria of the family BACTEROIDACEAE.
A genus of gram-negative, anaerobic, rod-shaped bacteria. Its organisms are normal inhabitants of the oral, respiratory, intestinal, and urogenital cavities of humans, animals, and insects. Some species may be pathogenic.
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY.
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
Conditions or pathological processes associated with the disease of diabetes mellitus. Due to the impaired control of BLOOD GLUCOSE level in diabetic patients, pathological processes develop in numerous tissues and organs including the EYE, the KIDNEY, the BLOOD VESSELS, and the NERVE TISSUE.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
A species of gram-negative, anaerobic, rod-shaped bacteria originally classified within the BACTEROIDES genus. This bacterium produces a cell-bound, oxygen-sensitive collagenase and is isolated from the human mouth.
Accumulations of microflora that lead to pathological plaque and calculus which cause PERIODONTAL DISEASES. It can be considered a type of BIOFILMS. It is subtly distinguished from the protective DENTAL PELLICLE.
Pathological processes involving the PERIODONTIUM including the gum (GINGIVA), the alveolar bone (ALVEOLAR PROCESS), the DENTAL CEMENTUM, and the PERIODONTAL LIGAMENT.
A numerical rating scale for classifying the periodontal status of a person or population with a single figure which takes into consideration prevalence as well as severity of the condition. It is based upon probe measurement of periodontal pockets and on gingival tissue status.
Inflammation and loss of PERIODONTIUM that is characterized by rapid attachment loss and bone destruction in the presence of little local factors such as DENTAL PLAQUE and DENTAL CALCULUS. This highly destructive form of periodontitis often occurs in young people and was called early-onset periodontitis, but this disease also appears in old people.
Inflammation and loss of connective tissues supporting or surrounding the teeth. This may involve any part of the PERIODONTIUM. Periodontitis is currently classified by disease progression (CHRONIC PERIODONTITIS; AGGRESSIVE PERIODONTITIS) instead of age of onset. (From 1999 International Workshop for a Classification of Periodontal Diseases and Conditions, American Academy of Periodontology)
The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.
Pathogenic infections of the brain, spinal cord, and meninges. DNA VIRUS INFECTIONS; RNA VIRUS INFECTIONS; BACTERIAL INFECTIONS; MYCOPLASMA INFECTIONS; SPIROCHAETALES INFECTIONS; fungal infections; PROTOZOAN INFECTIONS; HELMINTHIASIS; and PRION DISEASES may involve the central nervous system as a primary or secondary process.
Those components of an organism that determine its capacity to cause disease but are not required for its viability per se. Two classes have been characterized: TOXINS, BIOLOGICAL and surface adhesion molecules that effect the ability of the microorganism to invade and colonize a host. (From Davis et al., Microbiology, 4th ed. p486)
Proteins found in any species of bacterium.
The hollow thick-walled muscular organ in the female PELVIS. It consists of the fundus (the body) which is the site of EMBRYO IMPLANTATION and FETAL DEVELOPMENT. Beyond the isthmus at the perineal end of fundus, is CERVIX UTERI (the neck) opening into VAGINA. Beyond the isthmi at the upper abdominal end of fundus, are the FALLOPIAN TUBES.
A pair of ducts near the WOLFFIAN DUCTS in a developing embryo. In the male embryo, they degenerate with the appearance of testicular ANTI-MULLERIAN HORMONE. In the absence of anti-mullerian hormone, mullerian ducts give rise to the female reproductive tract, including the OVIDUCTS; UTERUS; CERVIX; and VAGINA.
Congenital structural abnormalities of the UROGENITAL SYSTEM in either the male or the female.
A triangular double membrane separating the anterior horns of the LATERAL VENTRICLES of the brain. It is situated in the median plane and bounded by the CORPUS CALLOSUM and the body and columns of the FORNIX (BRAIN).
Pathological processes involving any part of the UTERUS.
Endoscopic examination, therapy or surgery of the interior of the uterus.
Radiography of the uterus and fallopian tubes after the injection of a contrast medium.

Pathogenesis of cancrum oris (noma): confounding interactions of malnutrition with infection. (1/333)

This study showed that impoverished Nigerian children at risk for cancrum oris (noma) had significantly reduced plasma concentrations of zinc (< 10.8 micromol/L), retinol (< 1.05 micromol/L), ascorbate (< 11 micromol/L), and the essential amino acids, with prominently increased plasma and saliva levels of free cortisol, compared with their healthy counterparts. The nutrient deficiencies, in concert with previously reported widespread viral infections (measles, herpesviruses) in the children, would impair oral mucosal immunity. We postulate, subject to additional studies, that evolution of the oral mucosal ulcers including acute necrotizing gingivitis to noma is triggered by a consortium of microorganisms of which Fusobacterium necrophorum is a key component. Fusobacterium necrophorum elaborates several dermonecrotic toxic metabolites and is acquired by the impoverished children via fecal contamination resulting from shared residential facilities with animals and very poor environmental sanitation.  (+info)

Role of gingipains R in the pathogenesis of Porphyromonas gingivalis-mediated periodontal disease. (2/333)

It has been demonstrated that the Porphyromonas gingivalis cysteine proteinases (gingipains) activate and/or degrade a broad range of host proteins. Inactivation of gingipains R prior to infection of mice results in a decrease in the virulence of P. gingivalis. Analysis of mouse, rabbit, and chicken antisera raised to gingipain R1 demonstrated that the hemagglutinin domains of gingipains are very immunogenic; however, immunization of mice with a peptide derived from the hemagglutinin domain did not protect mice from P. gingivalis infection. Our recent studies indicate that immunization of mice with a peptide corresponding to the N-terminus of the catalytic domain of gingipains R results in the generation of an immune response that affords protection of mice from P. gingivalis infection. It is postulated that the protection observed results from the inactivation of the enzymatic activity of gingipains R as a result of antibody recognition of a processing site on the gingipain R precursor.  (+info)

Bacterium-dependent induction of cytokines in mononuclear cells and their pathologic consequences in vivo. (3/333)

Viridans streptococci are a heterogeneous group of gram-positive bacteria that are normal inhabitants of the mouth. These organisms are thought to contribute significantly to the etiology of infective endocarditis, although recently they have been implicated in serious infections in other settings. Another group of oral bacteria, gram-negative anaerobes, is associated with chronic dental infections, such as periodontal diseases or endodontic lesion formation. We evaluated the ability of the oral pathogens Streptococcus mutans and Porphyromonas endodontalis to induce a pathogenic response in vivo, with the goal of quantifying the inflammatory response in soft tissue by measuring leukocyte recruitment and hard tissues by measuring osteoclastogenesis. S. mutans induced a strong inflammatory response and was a potent inducer of osteoclast formation, while P. endodontalis was not. To further study the mechanisms by which P. endodontalis and S. mutans elicit significantly different levels of inflammatory responses in vivo, we tested the capacity of each to induce production of cytokines by mononuclear cells in vitro. S. mutans stimulated high levels of interleukin-12 (IL-12), gamma interferon (IFN-gamma), and tumor necrosis factor alpha (TNF-alpha), all of which are associated with inflammation, enhanced monocyte function, and generation of a Th1 response. In contrast, P. endodontalis stimulated production of IL-10 but not of TNF-alpha, IL-12, or IFN-gamma. These results demonstrate that oral pathogens differ dramatically in their abilities to induce inflammatory and immunoregulatory cytokines. Moreover, there is a high degree of correlation between the cytokine profile induced by these bacteria in vitro and their pathogenic capacity in vivo.  (+info)

Molecular interactions of Porphyromonas gingivalis fimbriae with host proteins: kinetic analyses based on surface plasmon resonance. (4/333)

Fimbriae of Porphyromonas gingivalis are thought to play an important role in the colonization and invasion of periodontal tissues. In this study, we analyzed the interactions of P. gingivalis fimbriae with human hemoglobin, fibrinogen, and salivary components (i.e., proline-rich protein [PRP], proline-rich glycoprotein [PRG], and statherin) based on surface plasmon resonance (SPR) spectroscopy with a biomolecular interaction analyzing system (BIAcore). The real-time observation showed that the fimbriae interacted more quickly with hemoglobin and PRG than with other proteins and more intensely with fibrinogen. The significant association constant (ka) values obtained by BIAcore demonstrated that the interactions between fimbriae and these host proteins are specific. These estimated Ka values were not too different; however, the Ka values for hemoglobin (2.43 x 10(6)) and fibrinogen (2.16 x 10(6)) were statistically greater than those for the salivary proteins (1.48 x 10(6) to 1.63 x 10(6)). The Ka value of anti-fimbriae immunoglobulin G for fimbriae was estimated to be 1. 22 x 10(7), which was 6.55-fold higher than the mean Ka value of the host proteins. Peptide PRP-C, a potent inhibitor of PRP-fimbriae interaction, dramatically inhibited fimbrial association to PRP and PRG and was also inhibitory against other host proteins by BIAcore. The binding of fimbriae to these proteins was also evaluated by other methods with hydroxyapatite beads or polystyrene microtiter plates. The estimated binding abilities differed considerably, depending on the assay method that was used. It was noted that the binding capacity of PRP was strongly diminished by immobilization on a polystyrene surface. Taken together, these findings suggest that P. gingivalis fimbriae possess a strong ability to interact with the host proteins which promote bacterial adherence to the oral cavity and that SPR spectroscopy is a useful method for analyzing specific protein-fimbriae interactions.  (+info)

CD4(+) T cells and the proinflammatory cytokines gamma interferon and interleukin-6 contribute to alveolar bone loss in mice. (5/333)

In this study, we used a mouse model to examine the role of the adaptive immune response in alveolar bone loss induced by oral infection with the human gram-negative anaerobic bacterium Porphyromonas gingivalis. Severe combined immunodeficient mice, which lack B and T lymphocytes, exhibited considerably less bone loss than did immunocompetent mice after oral infection, suggesting that lymphocytes contribute to this process. Bone loss after oral infection was decreased in mice deficient in major histocompatibility complex (MHC) class II-responsive CD4(+) T cells, but no change in bone loss was observed in mice deficient in MHC class I-responsive CD8(+) T cells or NK1(+) T cells. Mice lacking the cytokine gamma interferon or interleukin-6 also demonstrated decreased bone loss. These results suggest that the adaptive immune response, and in particular CD4(+) T cells and the proinflammatory cytokines that they secrete, are important effectors of bone loss consequent to P. gingivalis oral infection. The studies also reinforce the utility of the mouse oral infection model in dissecting the pathobiology of periodontal disease.  (+info)

Purification, characterization, and sequence analysis of a potential virulence factor from Porphyromonas gingivalis, peptidylarginine deiminase. (6/333)

The initiation and progression of adult-onset periodontitis has been associated with infection of the gingival sulcus by Porphyromonas gingivalis. This organism utilizes a multitude of virulence factors to evade host defenses as it establishes itself as one of the predominant pathogens in periodontal pockets. A feature common to many other oral pathogens is the production of ammonia due to its protective effect during acidic cleansing cycles in the mouth. Additionally, ammonia production by P. gingivalis has been proposed as a virulence factor due to its negative effects on neutrophil function. In this study, we describe the first purification of a peptidylarginine deiminase (PAD) from a prokaryote. PAD exhibits biochemical characteristics and properties that suggest that it may be a virulence agent. PAD deiminates the guanidino group of carboxyl-terminal arginine residues on a variety of peptides, including the vasoregulatory peptide-hormone bradykinin, to yield ammonia and a citrulline residue. The soluble protein has an apparent mass of 46 kDa, while the DNA sequence predicts a full-length protein of 61.7 kDa. PAD is optimally active at 55 degrees C, stable at low pH, and shows the greatest activity above pH 9.0. Interestingly, in the presence of stabilizing factors, PAD is resistant to limited proteolysis and retains significant activity after short-term boiling. We propose that PAD, acting in concert with arginine-specific proteinases from P. gingivalis, promotes the growth of the pathogen in the periodontal pocket, initially by enhancing its survivability and then by assisting the organism in its circumvention of host humoral defenses.  (+info)

Host responses to recombinant hemagglutinin B of Porphyromonas gingivalis in an experimental rat model. (7/333)

Porphyromonas gingivalis, a gram-negative, black-pigmented anaerobe, is among the microorganisms implicated in the etiology of adult periodontal disease. This bacterium possesses a number of factors, including hemagglutinins, of potential importance in virulence. Several hemagglutinin genes have been identified, cloned, and expressed in Escherichia coli. The purpose of this study was to characterize host responses to purified recombinant hemagglutinin B (rHag B), using the conventional Fischer rat as the experimental animal model. The effectiveness of immunization with rHag B on protection against experimental periodontal bone loss following infection with P. gingivalis was also evaluated. Groups of rats were immunized by the subcutaneous route with rHag B in complete Freund's adjuvant, immunized with rHag B and orally infected with P. gingivalis, nonimmunized and noninfected, or orally infected with P. gingivalis only. Serum and saliva samples were collected throughout the experiment and evaluated for serum immunoglobulin G (IgG) and IgM and salivary IgA antibody activity by enzyme-linked immunosorbent assay. No salivary IgA anti-Hag B activity was detected in the various groups of rats. A slight serum IgM response similar to that seen in preimmune samples was observed. Serum IgG antibody activity to Hag B was detected only in samples from rats immunized with rHag B. This response was primarily of the IgG1 and IgG2a subclasses, followed by IgG2b and low levels of IgG2c. Supernatants from rHag B-stimulated splenic lymphoid cell cultures from immunized rats contained high levels of gamma interferon, followed by interleukin-2 (IL-2), IL-10, and then IL-4. These results are consistent with the induction of T helper type 1 (Th1)- and Th2-like responses. Western blot analysis of sera derived from rHag B-immunized rats reacted with trichloroacetic acid (TCA) precipitates of P. gingivalis 33277, 381, A7A1-28, and W50, revealing a 50-kDa band reflective of Hag B. However, sera derived from rats immunized with P. gingivalis whole cells or from rats infected with P. gingivalis only did not react with rHag B but did react with TCA precipitates of P. gingivalis strains. Finally, radiographic measurements of periodontal bone loss indicated that rats immunized with rHag B had less bone loss than those infected with P. gingivalis only. These results demonstrate the effectiveness of purified rHag B in inducing a protective immune response and support the potential usefulness of this component of P. gingivalis in the development of a vaccine against adult periodontitis.  (+info)

Direct detection of Prevotella intermedia and P. nigrescens in suppurative oral infection by amplification of 16S rRNA gene. (8/333)

A specific 16S rDNA PCR and subsequent hybridisation reaction was designed to discriminate between strains of Prevotella intermedia (n = 15) and P. nigrescens (n = 15). This technique was then used to detect the presence of these two bacterial species in acute suppurative oral infection. A total of 36 pus samples aspirated from 26 peri-apical abscesses, three root canals, three periodontal abscesses, two cases of refractory periodontitis, one cyst and one haematoma was examined. A portion of the pus sample was processed by PCR and the remainder of the specimen was subjected to routine culture. The PCR-based technique gave an identical pattern of detection of P. intermedia or P. nigrescens to that obtained by culture for 30 of the 36 specimens. Either P. intermedia or P. nigrescens was present in 14 samples and neither species was detected in 16 samples. In the remaining six samples the PCR method indicated the presence of one (n = 3) or both (n = 3) of the Prevotella species but neither or only one species was isolated by culture. It is concluded that the presence of P. intermedia and P. nigrescens in pus can be detected rapidly and specifically by direct PCR amplification of 16S rDNA. P. nigrescens was detected more frequently than P. intermedia in suppurative peri-apical infection both by culture and PCR.  (+info)

TY - JOUR. T1 - Porphyromonas gingivalis Infection Induces Amyloid-β Accumulation in Monocytes/Macrophages. AU - Nie, Ran. AU - Wu, Zhou. AU - Ni, Junjun. AU - Zeng, Fan. AU - Yu, Weixian. AU - Zhang, Yufeng. AU - Kadowaki, Tomoko. AU - Kashiwazaki, Haruhiko. AU - Teeling, Jessica L.. AU - Zhou, Yanmin. PY - 2019/1/1. Y1 - 2019/1/1. N2 - Abnormal accumulation of amyloid-β (Aβ) in the brain is the most significant pathological hallmark of Alzheimers disease (AD). We have found that chronic systemic exposure to lipopolysaccharide of Porphyromonas gingivalis (P. gingivalis) induces the accumulation of Aβ in the brain of middle-aged mice. On the other hand, recent research has shown that circulating Aβ is transferred into the brain; however, the involvement of chronic systemic P. gingivalis infection in the peripheral Aβ metabolism is unknown. We hypothesized that chronic P. gingivalis infection expands Aβ pools in peripheral inflammatory tissues and thereby contributes to the accumulation ...
Periodontitis is a chronic inflammatory disease caused by exaggerated host immune responses to dysregulated microbiota in dental biofilms leading to degradation of tissues and alveolar bone loss. Porphyromonas gingivalis is a major periodontal pathogen and expresses several potent virulence factors. Among these factors, arginine and lysine gingipains are of special importance, both for the bacterial survival/proliferation and the pathological outcome. The major aim of this thesis was to develop and test novel methods for diagnosis and prevention of P. gingivalis infection and periodontitis. In study I, anti-P. gingivalis antibodies were developed in vitro for immunodetection of bacteria in clinical samples using a surface plasmon resonance (SPR)-based biosensor. Specific binding of the antibodies to P. gingivalis was demonstrated in samples of patients with periodontitis and the results were validated using real-time PCR and DNA-DNA checkerboard analysis. In study II, we elucidated the ...
The pathogenicity of the periodontal biofilm is highly dependent on a few key species, of which Porphyromonas gingivalis is considered to be one of the most important pathogens. P. gingivalis expresses a broad range of virulence factors, of these cysteine proteases (gingipains) are of special importance both for the bacterial survival/proliferation and for the pathological outcome. Several cell types, for example, epithelial cells, endothelial cells, dendritic cells, osteoblasts, and fibroblasts, reside in the periodontium and are part of the innate host response, as well as platelets, neutrophils, lymphocytes, and monocytes/macrophages. These cells recognize and respond to P. gingivalis and its components through pattern recognition receptors (PRRs), for example, Toll-like receptors and protease-activated receptors. Ligation of PRRs induces downstream-signaling pathways modifying the activity of transcription factors that regulates the expression of genes linked to inflammation. This is followed by the
Yes. Theres a lot of discussion about it. So, first of all, its a risk factor. So, often, when you see p. gingivalis, or when you see periodontitis, you often see, also, other diseases like diabetes. So, but, they showed the association. But the problem is: both diseases; or a lot of diseases, like cardiovascular diseases; are so complex and caused by different factors, thats its very difficult to find 1 cause or 1 relation. So, there has never been a causal relationship that has been demonstrated. So, what I can say is, maybe, if you have periodontitis with p. gingivalis, there are studies that demonstrate, so: the invasiveness of p. gingivalis. It can go to the liver, and there it can interact with the process of the glucose mechanism. So, the invasiveness, first of all: p. gingivalis makes that it may ... yes, I would say: induce the diabetes. But, on the other hand; you see, for diabetes patients, the problem is there: they may have a loss in bone density. And when you see to the ...
Principal Investigator:TSUKUBA Tomoko, Project Period (FY):2004 - 2005, Research Category:Grant-in-Aid for Scientific Research (C), Section:一般, Research Field:Functional basic dentistry
Researchers at the University at Buffalo have been able to identify two key components in saliva that could be used to predict the amount of oral bone loss in future.
Background: It has been suggested that bacterial infections have a role in the pathogenesis of rheumatoid arthritis (RA). P gingivalis, a Gram-negative, anaerobic rod, is one of the major pathogens associated with periodontal disease.. Objective: To examine P gingivalis infection and its effects on cell cycle progression and apoptosis of human articular chondrocytes.. Methods: Primary human chondrocytes cultured in monolayers were challenged with P gingivalis. Infection and invasion of P gingivalis into chondrocytes was analysed by scanning electron microscopy, double immunofluorescence and by antibiotic protection and invasion assay. Cell cycle progression of infected chondrocytes was evaluated by flow cytometry. Also, cell apoptosis was visualised by terminal deoxynucleotidyl transferase-mediated dUTP nick end labelling (TUNEL) of DNA strand breaks and by western blot analysis.. Results: Data showed that P gingivalis could adhere and infect primary human chondrocytes. After chondrocyte ...
K-antigen capsule is one of the key virulence factors of the oral pathogen Porphyromonas gingivalis. This cell surface structure is synthesized by proteins encoded by a series of genes in an operon that is transcribed as a large polycistronic message. Previously, a 77-bp inverted repeat region was identified upstream of the start codon of PG0106, the first gene in the synthesis cluster, and this inverted repeat was predicted to form a large stem-loop structure. Furthermore, two genes that flank the synthesis cluster (PG0104 and PG0121) were also found to be co-transcribed with the K-antigen capsule synthesis operon. Interestingly, these genes are both predicted to encode DNA binding proteins; indicated by their high similarity to other known DNA binding proteins. PG0104 shares a 57% sequence similarity to DNA topoisomerase III from Bacillus subtilis, while PG0121 is 72% similar to DNA binding protein HU of Bacillus caldotenax. The transcript levels of the K-antigen capsule synthesis genes in ...
K-antigen capsule is one of the key virulence factors of the oral pathogen Porphyromonas gingivalis. This cell surface structure is synthesized by proteins encoded by a series of genes in an operon that is transcribed as a large polycistronic message. Previously, a 77-bp inverted repeat region was identified upstream of the start codon of PG0106, the first gene in the synthesis cluster, and this inverted repeat was predicted to form a large stem-loop structure. Furthermore, two genes that flank the synthesis cluster (PG0104 and PG0121) were also found to be co-transcribed with the K-antigen capsule synthesis operon. Interestingly, these genes are both predicted to encode DNA binding proteins; indicated by their high similarity to other known DNA binding proteins. PG0104 shares a 57% sequence similarity to DNA topoisomerase III from Bacillus subtilis, while PG0121 is 72% similar to DNA binding protein HU of Bacillus caldotenax. The transcript levels of the K-antigen capsule synthesis genes in ...
Methods: in vivo laboratory, experimental research was conducted using posttest only control group design. The samples were 20 male Wistar rats divided into 4 groups. Groups I and II were groups injected using LPS P. gingivalis for 6 w and were decapited on the day 3 and day 7, groups III and IV were the control groups (not injected using LPS P. gingivalis) and decapited on the day 3 and day 7. Subsequently, conducting tissue preparation, staining using haematoxilin eosin, and calculating the number of osteoclasts and osteoblasts cells using a microscope (Optilab) with 400x magnification. The results of osteoblast and osteoclast cell calculation were analyzed using ANOVA and LSD one-way test. ...
Atherosclerotic vascular disease is a leading cause of myocardial infarction and cerebrovascular accident, and independent associations with periodontal disease (PD) are reported. PD is caused by polymicrobial infections and aggressive immune responses. Genomic DNA of Porphyromonas gingivalis, the best-studied bacterial pathogen associated with severe PD, is detected within atherosclerotic plaque. We examined causal relationships between chronic P. gingivalis oral infection, PD, and atherosclerosis in hyperlipidemic ApoEnull mice. ApoEnull mice (n = 24) were orally infected with P. gingivalis for 12 and 24 weeks. PD was assessed by standard clinical measurements while the aorta was examined for atherosclerotic lesions and inflammatory markers by array. Systemic inflammatory markers serum amyloid A, nitric oxide, and oxidized low-density lipoprotein were analyzed. P. gingivalis infection elicited specific antibodies and alveolar bone loss. Fluorescent in situ hybridization detected viable P. gingivalis
Porphyromonas gingivalis ATCC ® BAA-308D-5™ Designation: Genomic DNA from Porphyromonas gingivalis strain W83 TypeStrain=False Application:
Periodontitis is a chronic infectious disease that is highly prevalent worldwide and is characterized by inflammation of the gums, and loss of connective tissue and bone support. The Gram-negative anerobic bacterium Porphyromonas gingivalis is generally accepted as the main etiological agent for chronic periodontitis. The objective of this paper is to elucidate the feasibility of achieving protection against periodontitis though immunization against P. gingivalis. Until now, animal studies have showed no complete protection against P. gingivalis. However, current knowledge about P. gingivalis structures could be applicable for further research to develop a successful licensed vaccine and alternative therapeutic strategies. This review reveals that a multicomponent vaccine against P. gingivalis, which includes structures shared among P. gingivalis serotypes, will be feasible to induce broad and complete protection ...
The suitability of a mouse model for host response in the induction of alveolar bone loss by Porphyromonas gingivalis was explored. The mouths of immunocompetent and severe combined immunodeficient (SCID) mice were infected with P. gingivalis ATCC 53977. P. gingivalis was not isolated from the mouths of these mice before infection, but was present at least 42 days after infection. P. gingivalis-specific IgG was present in sera from the infected, immunocompetent mice at the end of these experiments (42 days). Specific IgG was not present in sham-infected or uninfected immunocompetent mice, nor in any immunodeficient mice. Specific IgM was not present in any sera at 42 days. Infected, immunocompetent mice of two strains showed significant bone loss in comparison to sham-infected or uninfected immunocompetent mice (p | 0.05). Infected SCID mice, which are genetically lacking both B and T lymphocytes, also showed significant bone loss compared with sham-infected or uninfected SCID mice (p | 0.05
Porphyromonas gingivalis is a highly proteolytic organism which metabolizes small peptides and amino acids. Indirect evidence suggests that the proteases produced by this microorganism constitute an important virulence factor. In this study, a gene bank of P. gingivalis W83 DNA was constructed by cloning 0.5- to 20-kb HindIII-cut DNA fragments into Escherichia coli DH5 alpha by using the plasmid vector pUC19. A clone expressing a protease from P. gingivalis was isolated on LB agar containing 1% skim milk. The clone contained a 3.0-kb insert that coded for a protease with an apparent molecular mass of 64 kDa. Sequencing part of the 3.0-kb DNA fragment revealed an open reading frame encoding a protein of 482 amino acids with a molecular mass of 62.5 kDa. Putative promoter and termination elements flanking the open reading frame were identified. The activity expressed in E. coli was extensively characterized by using various substrates and protease inhibitors, and the results suggest that it is ...
Chronic periodontitis is strongly associated with composition of the oral biofilm occupying the gingival crevicular aspect of the tooth and its associated root. Some gram-negative, red complex bacteria instigate periodontal bone loss in patients, principal among these Porphyromonas gingivalis. P. gingivalis is a late colonizer, indicating not only its physical location within the oral biofilm, but also the pathogenic dynamic of the interaction between P. gingivalis and the host innate immunity. Among several other subversive tactics, P. gingivalis has been shown to compel receptors vital to the orchestration of an appropriate immune response to co-associate and consequently signal in a way that directly benefits the pathogen. Upon interaction with human monocytes and murine macrophages, P. gingivalis has been shown to induce TLR2 and CXCR4 to co- associate in lipid rafts via its surface fimbriae. The ensuing crosstalk results in a cAMP dependent, PKA mediated inhibition of NF-KB which in turn leads
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
Toll-like receptors (TLRs) are a group of pathogen-associated molecular pattern receptors, which play an important role in in-nate immune signaling in response to microbial infection. It has been demonstrated that TLRs are differentially up regulated in response to microbial infection and chronic inflammatory diseases such as atherosclerosis. Furthermore hyperlipidemic mice deficient in TLR2, TLR4, and MyD88 signaling exhibit diminished inflammatory responses and decreased atherosclerosis. Accumulating evidence has implicated specific infectious agents including the periodontal disease pathogen Porphyromonas gingivalis in the progression of atherosclerosis. Evidence in humans suggesting that periodontal infection predisposes to atherosclerosis is derived from studies demonstrating that the periodontal pathogen P. gingivalis resides in the wall of atherosclerotic vessels and seroepidemiological studies demonstrating an association between pathogen-specific IgG antibodies and atherosclerosis. We ...
Cortexyme, Inc. (Nasdaq: CRTX), a clinical stage biopharmaceutical company pioneering a novel, disease-modifying therapeutic approach to treat what it believes to be a key underlying cause of Alzheimers (AD) and other degenerative diseases, today announced the publication of research further documenting the ability of the pathogen Porphyromonas gingivalis to invade neurons and trigger Alzheimers-like neuropathology.
Outer membrane protein A (OmpA) is a key outer membrane protein found in Gram-negative bacteria that contributes to several crucial processes in bacterial virulence. In Porphyromonas gingivalis, OmpA is predicted as a heterotrimer of OmpA1 and OmpA2 subunits encoded by adjacent genes. Here we describe the role of OmpA and its individual subunits in the interaction of P. gingivalis with oral cells. Using knockout mutagenesis, we show that OmpA2 plays a significant role in biofilm formation and interaction with human epithelial cells. We used protein structure prediction software to identify extracellular loops of OmpA2, and determined these are involved in interactions with epithelial cells as evidenced by inhibition of adherence and invasion of P. gingivalis by synthetic extracellular loop peptides and the ability of the peptides to mediate interaction of latex beads with human cells. In particular, we observe that OmpA2-loop 4 plays an important role in the interaction with host cells. These ...
Periodontal disease is of established aetiology in which polymicrobial synergistic ecology has become dysbiotic under the influence of Porphyromonas gingivalis. Following breakdown of the hosts protective oral tissue barriers, P. gingivalis migrates to developing inflammatory pathologies that associate with Alzheimers disease (AD). Periodontal disease is a risk factor for cardiovascular disorders (CVD), type II diabetes mellitus (T2DM), AD and other chronic diseases, whilst T2DM exacerbates periodontitis. This study analysed the relationship between the P. gingivalis/host interactome and the genes identified in genome-wide association studies (GWAS) for the aforementioned conditions using data from GWASdb (P
Porphyromonas gingivalis porphypain protein: isolated from Prophyromonas gingivalis W12; amino acid sequence in first source; GenBank U42210; do not confuse with PrtP from Lactococcus
Porphyromonas gingivalis KGP-381 protein: gene kgp(381) has high homology with the proteolytic domain of cysteine proteases/hemagglutination genes; MW 40 kDa; amino acid sequence in first source
Characterization of a second cell-associated Arg-specific cysteine proteinase of Porphyromonas gingivalis and identification of an adhesin-binding motif involved in association of the prtR and prtK proteinases and adhesins into large complexes
http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1932-6203&volume=7&issue=12&spage=e51008&epage=&date=2012&atitle=Baicalin+Downregulates+Porphyromonas+gingivalis+Lipopolysaccharide-Upregulated+IL-6+and+IL-8+Expression+in+Human+Oral+Keratinocytes+by+Negative+Regulation+of+TLR+ ...
Results Intratracheal infection with 5x107 P. gingivalis did not lead to systemic infection and live bacteria were eliminated twenty-four hours postinfection from the lungs. Moreover, no live bacteria were found in other organs and blood at any time after bacterial administration. However, significant ankle swelling occurred in DBA/1 mice 7 days after P. gingivalis challenge. In contrast to DBA/1, BALB/c and C57BL/6 mice were resistant to joint inflammation generated by P. gingivalis intratracheal infection. The arthritic joints in DBA/1 mice exhibited inflammatory changes in synovial tissue. Serum proinflammatory mediators such as IL-6, TNF-alpha, IL-10, MCP-1 were found to be elevated one week after infection, which correlated with the onset of inflammatory changes in the joints.. Other routes of P. gingivalis administration did not lead to inflammatory changes in the joints.. ...
Projekt „Repozytorium otwartego dostępu do dorobku naukowego i dydaktycznego UJ współfinansowany w ramach poddziałania 2.3.1 „Cyfrowe udostępnianie zasobów nauki Programu Operacyjnego Polska Cyfrowa z Europejskiego Funduszu Rozwoju Regionalnego i budżetu państwa na podstawie umowy o dofinansowanie nr POPC.02.03.01-00-0030/17-00 ...
Porphyromonas gingivalis (P.Gingivalis) es un microorganismo comprometido en el inicio y progresión de la enfermedad periodontal crónica y agresiva, y es considerado su principal agente etiológico. Esta bacteria cuenta con una serie defactores de virulencia que le permiten, iniciar el proceso infeccioso, perpetuar la infección y también transformar la placa dental benigna en una comunidad microbiana patógena. Estudiar sus factores de virulencia y su capacidad de modular la respuesta inmunológica del huésped es muy importante para comprender el papel de este patógeno en el desarrollo y establecimiento de la enfermedad. Esta revisión proporciona una visión actual sobre los factores de virulencia y su impacto sobre la respuesta inmunológica en relación con la patogénesis de la enfermedad periodontal. Porphyromonas gingivalis (P. Gingivalis) is a microorganism involved in the onset and progression of chronic and aggressive periodontal disease, and is considered its main etiological ...
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
Principal Investigator:田中 雅子, Project Period (FY):1991, Research Category:Grant-in-Aid for Encouragement of Young Scientists (A), Research Field:Morphological basic dentistry
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Comparison of P. gingivalis HmuY and its homologs from P. intermedia and T. forsythia.Amino acid alignment (A) and approximated protein structures (B). P. inter
It has been demonstrated that the Porphyromonas gingivalis cysteine proteinases (gingipains) activate and/or degrade a broad range of host proteins. Inactivation of gingipains R prior to infection of mice results in a decrease in the virulence of P. gingivalis. Analysis of mouse, rabbit, and chicken antisera raised to gingipain R1 demonstrated that the hemagglutinin domains of gingipains are very immunogenic; however, immunization of mice with a peptide derived from the hemagglutinin domain did not protect mice from P. gingivalis infection. Our recent studies indicate that immunization of mice with a peptide corresponding to the N-terminus of the catalytic domain of gingipains R results in the generation of an immune response that affords protection of mice from P. gingivalis infection. It is postulated that the protection observed results from the inactivation of the enzymatic activity of gingipains R as a result of antibody recognition of a processing site on the gingipain R precursor.. ...
Background: Porphyromonas gingivalis is a gram-negative bacterium that causes destructive chronic periodontitis. In addition, this bacterium is also involved in the development of cardiovascular disease. The aim of this study was to investigate the effects of P. gingivalis infection on gene and protein expression in human aortic smooth muscle cells (AoSMCs) and its relation to cellular function.. Results: AoSMCs were exposed to viable P. gingivalis for 24 h, whereafter confocal fluorescence microscopy was used to study P. gingivalis invasion of AoSMCs. AoSMCs proliferation was evaluated by neutral red assay. Human genome microarray, western blot and ELISA were used to investigate how P. gingivalis changes the gene and protein expression of AoSMCs. We found that viable P. gingivalis invades AoSMCs, disrupts stress fiber structures and significantly increases cell proliferation. Microarray results showed that, a total of 982 genes were identified as differentially expressed with the threshold log2 ...
TY - JOUR. T1 - Porphyromonas gingivalis may multiply and advance within stratified human junctional epithelium in vitro. AU - Papapanou, P. N.. AU - Sandros, J.. AU - Lindberg, K.. AU - Duncan, M. J.. AU - Niederman, R.. AU - Nannmark, U.. PY - 1994. Y1 - 1994. M3 - Article. C2 - 7799218. VL - 29. SP - 374. EP - 375. JO - Journal of Periodontal Research. JF - Journal of Periodontal Research. SN - 0022-3484. IS - 5. ER - ...
Porphyromonas gingivalis, the major etiologic agent of chronic periodontitis, produces a broad spectrum of virulence factors, including Arg- and Lys-gingipain cysteine proteinases. In this study, we investigated the capacity of P. gingivalis gingipains to trigger a proinflammatory response in human monocyte-derived macrophages. Both Arg- and Lys-gingipain preparations induced the secretion of TNF-α and IL-8 by macrophages. Stimulation of macrophages with Arg-gingipain A/B preparation at the highest concentration was associated with lower amounts of cytokines detected, a phenomenon likely related to proteolytic degradation. The inflammatory response induced by gingipains was not dependent of their catalytic activity since heat-inactivated preparations were still effective. Stimulating macrophages with gingipain preparations was associated with increased levels of phosphorylated p38α MAPK suggesting its involvement in cell activation. In conclusion, our study brought clear evidence that P. gingivalis
TY - JOUR. T1 - Influence of immunization on Porphyromonas gingivalis colonization and invasion in the mouse chamber model. AU - Genco, C. A.. AU - Kapczynski, D. R.. AU - Cutler, C. W.. AU - Arko, R. J.. AU - Arnold, R. R.. N1 - Copyright: Copyright 2020 Elsevier B.V., All rights reserved.. PY - 1992. Y1 - 1992. N2 - The effects of immunization with invasive or noninvasive Porphyromonas (Bacteroides) gingivalis strains on the pathogenesis of infection in a mouse chamber model were examined. BALB/c mice were immunized by a single injection of heat-killed P. gingivalis invasive strain A7436 or W83 or noninvasive strain 33277, HG405, or 381 directly into subcutaneous chambers. P. gingivalis-specific antibody was detected in chamber fluid 21 days postimmunization, and mice were subsequently challenged by injection of exponential-phase P. gingivalis into chambers. Immunization with A7436 or W83 followed by challenge with A7436 protected mice against secondary abscess formation and death; however, P. ...
Porphyromonas gingivalis, a periodontal pathogen, can invade primary cultures of gingival epithelial cells. Optimal invasion occurred at a relatively low multiplicity of infection (i.e., 100) and demonstrated saturation at a higher multiplicity of infection. Following the lag phase, during which bacteria invaded poorly, invasion was independent of growth phase. P. gingivalis was capable of replicating within the epithelial cells. Invasion was an active process requiring both bacterial and epithelial cell energy production. Invasion was sensitive to inhibitors of microfilaments and microtubules, demonstrating that epithelial cell cytoskeletal rearrangements are involved in bacterial entry. P. gingivalis, but not epithelial cell, protein synthesis was necessary for invasion. Invasion within the epithelial cells was not blocked by inhibitors of protein kinase activity. Invasion was inhibited by protease inhibitors, suggesting that P. gingivalis proteases may be involved in the invasion process. ...
TY - JOUR. T1 - Innate immune recognition of invasive bacteria accelerates atherosclerosis in apolipoprotein E-deficient mice. AU - Gibson, Frank C.. AU - Hong, Charlie. AU - Chou, Hsin H.. AU - Yumoto, Hiromichi. AU - Chen, Jiqiu. AU - Lien, Egil. AU - Wong, Jodie. AU - Genco, Caroline Attardo. PY - 2004/6/8. Y1 - 2004/6/8. N2 - Background - Infectious diseases have emerged as potential risk factors for cardiovascular disease (CVD). Epidemiological studies support a connection between periodontal disease, a chronic inflammatory disease of the supporting tissues of the teeth, and CVD. Methods and Results - To directly test the connection between periodontal disease and atherosclerosis, apoE-/- mice were orally challenged with the periodontal disease pathogen Porphyromonas gingivalis or an invasion-impaired P gingivalis fimbriae-deficient mutant (FimA-). Both wild-type P gingivalis and the FimA- mutant were detected in blood and aortic arch tissue of apoE-/- mice by PCR after challenge. ApoE-/- ...
Polyphosphate (polyP) has bactericidal activity against a gram-negative periodontopathogen Porphyromonas gingivalis, a black-pigmented gram-negative anaerobic rod. However, current knowledge about the mode of action of polyP against P. gingivalis is incomplete. To elucidate the mechanisms of antibacterial action of polyP against P. gingivalis, we performed the full-genome gene expression microarrays, and gene ontology (GO) and protein-protein interaction network analysis of differentially expressed genes (DEGs). We successfully identified 349 up-regulated genes and 357 down-regulated genes (|1.5-fold, P | 0.05) in P. gingivalis W83 treated with polyP75 (sodium polyphosphate, Nan+2PnO3n+1; n = 75). Real-time PCR confirmed the up- and down-regulation of some selected genes. GO analysis of the DEGs identified distinct biological themes. Using 202 DEGs belonging to the biological themes, we generated the protein-protein interaction network based on a database of known and predicted protein interactions. The
Gln-70, which is located near the active-site metal, is conserved in aligned amino acid sequences of iron-containing superoxide dimutases (Fe-SODs) and cambialistic SOD from Porphyromonas gingivalis, but is complementarily substituted with Gln-142 in manganese-containing SODs (Mn-SODs). In order to clarify the contribution of this exchange of Gln to the metal-specific activity of P. gingivalis SOD, we have prepared a mutant of the enzyme with conversions of Gln-70 to Gly and Ala-142 to Gln. The ratio of the specific activities of Mn- to Fe-reconstituted P. gingivalis SOD increased from 1.4 in the wild-type to 3.5 in the mutant SODs. Furthermore, the visible absorption spectra of the Mn- and Fe-reconstituted mutant SODs more closely resembled that of Mn-specific SOD than that of the wild-type SOD. We conclude that a difference in configuration of the Gln residues of P. gingivalis SOD partially accounts for the metal-specific activity of the enzyme.. ...
Download Free Full-Text of an article Study of Porphyromonas gingivalis in periodontal diseases: A systematic review and meta-analysis
Oral mucosa provides the first line of defense against a diverse array of environmental and microbial irritants by forming the barrier of epithelial cells interconnected by multiprotein tight junctions (TJ), adherens junctions, desmosomes, and gap junction complexes. Grainyhead-like 2 (GRHL2), an epithelial-specific transcription factor, may play a role in the formation of the mucosal epithelial barrier, as it regulates the expression of the junction proteins. The current study investigated the role of GRHL2 in the Porphyromonas gingivalis (Pg)-induced impairment of epithelial barrier functions. Exposure of human oral keratinocytes (HOK-16B and OKF6 cells) to Pg or Pg-derived lipopolysaccharides (Pg LPSs) led to rapid loss of endogenous GRHL2 and the junction proteins (e.g., zonula occludens, E-cadherin, claudins, and occludin). GRHL2 directly regulated the expression levels of the junction proteins and the epithelial permeability for small molecules (e.g., dextrans and Pg bacteria). To explore ...
Summary The sequence of events involved in haemagglutination and lysis of erythrocytes by washed cells, vesicles and the culture supernate of Porphyromonas gingivalis strain W83 was monitored by 51Cr release and transmission electronmicroscopy. All preparations, except capsular material and lipopolysaccharide, caused haemagglutination and, by a slow process of attachment and specific attack on the surface structures of the red blood cells, produced minute pores and eventual leakage of cellular contents. N-acetylglucosamine, N-acetylgalactosamine and several other sugars such as glucose and sucrose had no effect on haemagglutination. Antiserum raised against a cloned haemagglutinin of P. gingivalis strain 381 inhibited the activity of strain W83 cells, vesicles and supernate. The antiserum-neutralised supernate lost 70-80% of its hydrolytic activity towards α-N-benzoyl-L-arginine-4-nitroanilide but the residual activity behaved in a manner similar to the native supernate in that it was completely
Looking for online definition of sulcus gingivalis in the Medical Dictionary? sulcus gingivalis explanation free. What is sulcus gingivalis? Meaning of sulcus gingivalis medical term. What does sulcus gingivalis mean?
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Three-dimensional (3D) printing has been applied extensively not only in human, but also veterinary medicine. However, the technique is still used in the clinical area for a surgical plan or education prior to surgery. Thus, we report a case of reconstruction after tumor removal surgery with the use of a 3D-printed scaffold. A 12-year-old female mixed dog had a left caudal maxillary mass. Based on computed tomography images, a defect was confirmed on the maxillary bone due to the oral mass, and a surgical plan was designed to remove the oral mass and graft the 3D printed scaffold ...
Affiliation (Current):東京医科歯科大学,大学院医歯学総合研究科,准教授, Research Field:Conservative dentistry,Periodontal dentistry,Periodontal dentistry, Keywords:歯周病原性細菌,歯周疾患,Porphyromonas gingivalis,ELISA法,歯周炎,歯周組織,ICAM-1,VCAM-1,成人性歯周炎,歯周病, # of Research Projects:16, # of Research Products:43
Ultrastructure of the AgB oligomers analyzed by TEM.TEM images from rAgB8/1 (A), rAgB8/2 (B), rAgB8/3 (C), and AgB (D) oligomers. Recombinant AgB subunits were
Jual Rumah Rp 600juta, Depok Parung Bingung dekat Kubah Emas, Pas Belakang Rumah Sakit Asy-Syifa dan di belakang Sekolah Alam Jl. Meruyung. Di dalam Komplek ada PAUD di samping Mushola. LB 83m2, LT 143m2, Car Port, 2 Kamar Tembok, 1 Kamar Sekat, Ruang Tamu, Dapur, 2 Kamar Mandi, 1 Gudang, Taman Depan dan Belakang ...
The B. fragilis group is the most commonly isolated Bacteroidaceae in anaerobic infections, especially those that originate ... It is part of the normal microbiota of the human colon and is generally commensal, but can cause infection if displaced into ... Bacteroides infections at eMedicine Brook I (June 2010). "The role of anaerobic bacteria in bacteremia". Anaerobe. 16 (3): 183- ... B. fragilis is involved in 90% of anaerobic peritoneal infections. It also causes bacteremia associated with intra-abdominal ...
... bacteroidaceae infections MeSH C01.252.400.110.109 - bacteroides infections MeSH C01.252.400.126 - bartonellaceae infections ... moraxellaceae infections MeSH C01.252.400.560.022 - acinetobacter infections MeSH C01.252.400.610 - mycoplasmatales infections ... salmonella infections, animal MeSH C01.252.400.310.821.873 - typhoid fever MeSH C01.252.400.310.850 - serratia infections MeSH ... bordetella infections MeSH C01.252.400.143.740 - whooping cough MeSH C01.252.400.155 - borrelia infections MeSH C01.252.400.155 ...
"Bacteroides Infection: Overview - eMedicine". Archived from the original on 22 December 2008. Retrieved 2008-12-11.. ... Some species (B. fragilis, for example) are opportunistic human pathogens, causing infections of the peritoneal cavity, ... Bacteroidaceae Genus: Bacteroides. Castellani & Chalmers 1919[1] Species *B. acidifaciens. *B. barnesiaes[2] ...
"Bacteroides Infection: Overview - eMedicine". Arquivado dende o orixinal o 22 de decembro de 2008. Consultado o 2008-12-11.. ... Bacteroidaceae. Xénero: Bacteroides. Castellani & Chalmers 1919 Especies *B. acidifaciens. *B. distasonis (reclasifidado como ...
Post-operative wound infection caused by bacteroidaceae family Abdel Aziz Abbas; New Egypt. J. Med. 1989; 3 (5): 1837-1841 New ... Keywords: Surgical Wound Infection Board Subjects: Postoperative Complications ,Bacteroidaceae Citation: Abbas Abdel Aziz , ... Post-operative wound infection caused by bacteroidaceae family, New Egypt. J. Med. 1989; 3 (5): 1837-1841 Abstract English ... 6%] yielded Bacteroidaceae members, 8 of them [13. 7%] were due to Bacteroides fragilis, 2 [3. 4%] were due to Bacteroides ...
Diabetes has been identified as an important risk factor for infection. But relatively little is known about how diabetes ... Bacteroidaceae Infections / complications * Bacteroidaceae Infections / immunology* * Chemokine CCL2 / genetics * Chemokine ... Diabetes has been identified as an important risk factor for infection. But relatively little is known about how diabetes ...
Our data on sequence similarity and cross-reactivity with bacterial enolase may indicate a role for bacterial infection, ... Bacteroidaceae Infections / immunology* * Biomarkers, Tumor / chemistry * Biomarkers, Tumor / immunology* * Case-Control ... Our data on sequence similarity and cross-reactivity with bacterial enolase may indicate a role for bacterial infection, ...
The B. fragilis group is the most commonly isolated Bacteroidaceae in anaerobic infections, especially those that originate ... It is part of the normal microbiota of the human colon and is generally commensal, but can cause infection if displaced into ... Bacteroides infections at eMedicine Brook I (June 2010). "The role of anaerobic bacteria in bacteremia". Anaerobe. 16 (3): 183- ... B. fragilis is involved in 90% of anaerobic peritoneal infections. It also causes bacteremia associated with intra-abdominal ...
Bacteroidaceae Infections/metabolism*. *Endothelial Cells/metabolism*/microbiology. *Porphyromonas gingivalis/metabolism*/ ... In this study, we demonstrate that P. gingivalis infection of HAEC resulted in the rapid cleavage of receptor interacting ... In this study, we demonstrate that P. gingivalis infection of HAEC resulted in the rapid cleavage of receptor interacting ...
... bacteroidaceae infections MeSH C01.252.400.110.109 - bacteroides infections MeSH C01.252.400.126 - bartonellaceae infections ... moraxellaceae infections MeSH C01.252.400.560.022 - acinetobacter infections MeSH C01.252.400.610 - mycoplasmatales infections ... salmonella infections, animal MeSH C01.252.400.310.821.873 - typhoid fever MeSH C01.252.400.310.850 - serratia infections MeSH ... bordetella infections MeSH C01.252.400.143.740 - whooping cough MeSH C01.252.400.155 - borrelia infections MeSH C01.252.400.155 ...
B. fragilis group is the most commonly isolated Bacteroidaceae in anaerobic infections, especially those that originate from ... The B. fragilis group is the species of Bacteroidaceae isolated with greatest frequency in clinical specimens. These organisms ... It is the most common species of anaerobic bacteria isolated from human soft tissue infections. ...
The authors also reported that the relative abundance of Lactobacillaceae was increased whereas the Bacteroidaceae was ... Apart from that, the gut microbiota protects the host against infections via several mechanisms. The microbes reside in the gut ... recruited to infection sites, thus leading to the ineffective elimination of pathogen from the gut (Brazil et al., 2013). ... OTA-treated animals experienced faster and more harmful parasite infections (provoked by Eimeria acervulina and E. adenoeides) ...
... difficile infection (CDI) among inpatients with diarrhea, in order to further explain the pathogenesis of this infection as ... These gut taxa contribute to the intestinal dysbiosis associated with C. difficile infection. ... in order to further explain the pathogenesis of this infection as well as to potentially guide new CDI therapies. Twenty-four ... Fecal samples from both cohorts were dominated by Lachnospiraceae, Bacteroidaceae, and Ruminococcaceae families (Figure 2). Non ...
Bacteroidaceae Infections Biomarkers Disease Models, Animal Enzyme-Linked Immunosorbent Assay HMGB1 Protein ... inoculated MI group compared to the PBS-injected MI group.Infection with P.g. after MI enhanced myocardial HMGB1 expression. ...
Acute dacryocystitis usually induces preseptal infection. In rare instances the infection that is confined to the lacrimal sac ... Lipidomics & Rhinovirus Infection. Lipidomics can be used to examine the lipid species involved with pathogenic conditions, ... infection can lead to death. This feed covers recent research on COVID-19. ... secondary to acute dacryocystitis and review the literature of orbital cellulitis resulting from acute lacrimal sac infection. ...
Bacteroidaceae Infections/complications*. *Bacteroidaceae Infections/pathology. *Carotid Artery Diseases/microbiology. *Carotid ...
Bacteroidaceae Infections/diagnosis*. *Bacteroidaceae Infections/microbiology. *Biomarkers/metabolism. *Cysteine Endopeptidases ...
Bacteroidaceae Infections/epidemiology , Bacteroidaceae Infections/microbiology , Bacteroidaceae Infections/pathology , ... Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Young Adult , Bacteroidaceae Infections/epidemiology ... Gram-Positive Bacterial Infections/microbiology , Gram-Positive Bacterial Infections/pathology , Actinobacillus Infections/ ... Fusobacterium Infections/epidemiology , Fusobacterium Infections/microbiology , Fusobacterium Infections/pathology , ...
Actinobacillus Infections , Diagnosis , Adult , Aggregatibacter actinomycetemcomitans , Bacteroidaceae Infections , Diagnosis ... Bacteroidaceae Infections/complications , Dacryocystitis/complications , Gram-Positive Bacterial Infections/complications , ... Bacteroidaceae Infections/diagnosis , Bacteroides/classification , Bacteroides Infections/diagnosis , Benzoylarginine-2- ... Apoptosis , Bacteroidaceae Infections , Cell Proliferation , Cells, Cultured , Endothelial Cells , Cell Biology , Humans , ...
The local destruction of periodontitis is believed to result from a bacterial infection of the gingival sulcus, and several ...
... superficial pyoderma and oral cavity/dental infections caused by or associated with clindamycin-sensitive staphylococci, ... bacteroidaceae, Fusobacterium necrophorum, Clostridium perfringens and osteomyelitis caused by Staphylococcus aureus in dogs. ... superficial pyoderma and oral cavity/dental infections. Tablets sold individually. Legal Category: POM-V ,...[More info] ... superficial pyoderma and oral cavity/dental infections. Tablets sold individually. Legal Category: POM-V ,...[More info] ...
Bacteroidaceae Infections. *Base Sequence. *beta-Galactosidase. *Biopsy. *Blood Flow Velocity. *Blood Pressure ...
At the family level, Lachnospiraceae (45.8%), Ruminococcaceae (17.4%), and Bacteroidaceae (16.1%) sequences dominated the ... difficile infection. This lack of difference between CDI and CDN also suggests that C. difficile acquisition or infection alone ... Fecal bacteriotherapy for recurrent Clostridium difficile infection. Anaerobe 15:285-289.. OpenUrlCrossRefPubMedWeb of Science ... Clostridium difficile infection (CDI) causes nearly half a million cases of diarrhea and colitis in the United States each year ...
It is associated with extraintestinal infections including abscesses, and soft tissue infections, as well as diarrheal diseases ...
Infection and Immunity Feb 2002, 70 (2) 928-937; DOI: 10.1128/IAI.70.2.928-937.2002 ... Infection and Immunity Feb 2002, 70 (2) 928-937; DOI: 10.1128/IAI.70.2.928-937.2002 ... During infection of its host and in response to the environmental stimuli, the pathogen elaborates a broad spectrum of ... Bacterial infection as assessed by in vivo gene expression. Proc. Natl. Acad. Sci. USA94:934-939. ...
Antibiosis, Bacterial Proteins, genetics, metabolism, Bacteroidaceae Infections, microbiology, Biofilms, growth & development, ...
P. gingivalis infection induces TNF-α production in macrophages via a TLR2-dependent pathway. Peritoneal macrophages from WT, ... TLR2 contributes to TNF-α production by murine macrophages in response to P. gingivalis infection.We and others (6, 11) ... Thank you for sharing this Infection and Immunity article.. NOTE: We request your email address only to inform the recipient ... It is tempting to speculate that chronic inflammation in response to P. gingivalis infection of the macrophage results from the ...
... study suggests that the previously reported link between periodontitis and RA could be accounted for by P gingivalis infection ... Humans, Porphyromonas gingivalis, Bacteroidaceae Infections, Arthritis, Rheumatoid, Periodontitis, Autoimmune Diseases, ... Antibodies to Porphyromonas gingivalis Indicate Interaction Between Oral Infection, Smoking, and Risk Genes in Rheumatoid ... Antibodies to Porphyromonas gingivalis Indicate Interaction Between Oral Infection, Smoking, and Risk Genes in Rheumatoid ...
Anaerobic infections in an Indian tertiary care hospital with special reference to Bacteroidaceae. J Infect. 1999;38:54-5. DOI ... Present status of therapy for anaerobic infections. Clin Infect Dis. 1996;23(Suppl 1):S9-14. DOIPubMed ... Metronidazole resistant Bacteroides fragilis infection of a prosthetic hip joint. J Infect. 1990;20:129-33. DOIPubMed ... Infections in the cancer patient. In: Devita VT Jr, Hellman S, Rosenberg SA, editors. Cancer. Principles and practice of ...
Gram-Negative Bacterial Infections. *Aliivibrio Infections. *Anaplasmataceae Infections. *Bacteroidaceae Infections. * ... "Pseudomonas Infections" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... This graph shows the total number of publications written about "Pseudomonas Infections" by people in Harvard Catalyst Profiles ... Below are MeSH descriptors whose meaning is related to "Pseudomonas Infections".. * ...
Zie ook: URINARY TRACT INFECTIONS. BACTEROIDACEAE INFECTIONS. Zie ook: BACTERI LE INFECTIES BACTERIAL INFECTIONS. Zie ook: GRAM ... BACILLACEAE INFECTIONS. Zie ook: BACTERI LE INFECTIES BACTERIAL INFECTIONS. Zie ook: GRAM-POSITIVE BACTERIAL INFECTIONS. Zie ... Zie ook: INFECTIES INFECTIONS. Zie ook: INFECTIOUS SKIN DISEASES. Zie ook: BACTERI LE INFECTIES BACTERIAL INFECTIONS. Zie ook: ... Zie ook: BACTERI LE INFECTIES BACTERIAL INFECTIONS. Zie ook: GRAM-NEGATIVE BACTERIAL INFECTIONS. Zie ook: BRUCELLA. Zie ook: ...
Gram-Negative Bacterial Infections. *Aliivibrio Infections. *Anaplasmataceae Infections. *Bacteroidaceae Infections. * ... "Piscirickettsiaceae Infections" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ... Infections with bacteria of the family PISCIRICKETTSIACEAE, causing septicemic disease of salmonid fish (SALMONIDAE). ... This graph shows the total number of publications written about "Piscirickettsiaceae Infections" by people in this website by ...
  • Bacteroides infections at eMedicine Brook I (June 2010). (wikipedia.org)
  • The B. fragilis group is the most commonly isolated Bacteroidaceae in anaerobic infections, especially those that originate from the gastrointestinal microbiota. (wikipedia.org)
  • Metronidazole is the drug of choice for empirical coverage of anaerobic infections. (cdc.gov)
  • It makes up at least 2% of the normal flora in the body accountable for at most 80% of anaerobic infections. (biology-online.org)
  • Anaerobic infections. (vetstream.com)
  • This study sought to characterize the bacterial and fungal microbiota changes associated with Clostridium difficile infection (CDI) among inpatients with diarrhea, in order to further explain the pathogenesis of this infection as well as to potentially guide new CDI therapies. (frontiersin.org)
  • Clindacyl Tablets are indicated for the treatment of infected wounds, abscesses, superficial pyoderma and oral cavity/dental infections caused by or associated with clindamycin-sensitive staphylococci, streptococci, bacteroidaceae, Fusobacterium necrophorum, Clostridium perfringens and osteomyelitis caused by Staphylococcus aureus in dogs. (vetuk.co.uk)
  • Clostridium difficile infection (CDI) causes nearly half a million cases of diarrhea and colitis in the United States each year. (asm.org)
  • The mortality rate for Clostridium difficile infection (CDI) is estimated to be 1 to 2.5%, contributing to 14,000 deaths per year in the United States ( 1 - 3 ). (asm.org)
  • Treatment of infected wounds, abscesses, superficial pyoderma and oral cavity/dental infections caused by or associated with clindamycin-sensitive staphylococci, streptococci,bacteroidaceae, Fusobacterium necrophorum, Clostridium perfringens and osteomyelitis caused by Staphylococcus aureus. (dietvet.com)
  • Cirrhosis from viral infection has unique bacterial or fungal profiles, which include increased numbers of Prevotella , Streptococcus , Staphylococcaceae, and Enterococcus , as well as decreased Ruminococcus and Clostridium . (hindawi.com)
  • The intestinal tract of commercially hatched chicks is gradually colonised from environmental sources only, however, if the chicks are provided experimentally with microbiota from a hen they can be colonised by adult-type microbiota from the very first days of life and become resistant to infections with pathogenic Escherichia coli, Clostridium perfringens, or Salmonella. (efeedlink.com)
  • Fecal microbiota transplantation (FMT), a unique method to reestablish a sustained balance in the disrupted microbiota of diseased intestine, has demonstrated great success in the treatment of recurrent Clostridium difficile infection and has gained increasing acceptance in clinical use. (gastroenterologyandhepatology.net)
  • It is part of the normal microbiota of the human colon and is generally commensal, but can cause infection if displaced into the bloodstream or surrounding tissue following surgery, disease, or trauma. (wikipedia.org)
  • These data demonstrate associations between the depletion of Ruminococcaceae , Lachnospiraceae , and butyrogenic bacteria in the gut microbiota and nosocomial diarrhea, including C. difficile infection. (asm.org)
  • Intestinal microbiota imbalance and the infections caused by F. nucleatum might be regulated by therapeutic intervention. (beds.ac.uk)
  • Emerging research on the role of the gut microbiota in HIV infection highlights a complex and clinically important relationship. (biomedcentral.com)
  • One challenge to studying the relationship between perinatally acquired HIV infection and the oral microbiota is that children are born with HIV, before they have an established microbiome. (biomedcentral.com)
  • The purpose of this study was to characterize the urinary microbiota in women who are planning treatment for urgency urinary incontinence and to describe clinical associations with urinary symptoms, urinary tract infection, and treatment outcomes. (cdc.gov)
  • The correct development of normal gut microbiota is important for young individuals, which are always more susceptible to infections than adults. (asm.org)
  • Fecal microbiota transplants (FMT) are an effective treatment for patients with gut microbe dysbiosis suffering from recurrent C. difficile infections. (beds.ac.uk)
  • These analyses provided starting points to evaluate the chicken gut microbiota and potentially to develop biomarkers for infections. (asm.org)
  • In fact, B. fragilis , the most abundant species in the microbiota of healthy people, can give in these cases very serious infections and is the most important anaerobic pathogen bacterium in humans (Mancuso et al 2005). (wordpress.com)
  • Finally, we identified several microbes that correlated with immune readouts in both fecal recipients and donors, and with in vitro HIV infection, which suggests a role for gut microbiota in immune activation and potentially HIV acquisition in MSM. (newsreportsite.org)
  • It also causes bacteremia associated with intra-abdominal infections, peritonitis and abscesses following rupture of viscus, and subcutaneous abscesses or burns near the anus. (wikipedia.org)
  • Clindacyl Tablets are used for the treatment of infected wounds, abscesses, superficial pyoderma and oral cavity/dental infections. (vetuk.co.uk)
  • It is associated with extraintestinal infections including abscesses, and soft tissue infections, as well as diarrheal diseases. (cdc.gov)
  • Some species can cause or exacerbate abscesses and other infections in humans if they gain access and tissues. (gopetsamerica.com)
  • Foul-smelling abscesses, gas, and putrefaction are characteristic of infection with this organism. (thefreedictionary.com)
  • Fusobacterium nucleatum is a strict anaerobic microorganism that causes disease entities such as periodontal and soft tissue abscesses, pulmonary and intraabdominal infections and very rarely intracerebral infections. (biomedcentral.com)
  • Infections with bacteria of the genus PSEUDOMONAS. (harvard.edu)
  • A genus that includes many species of obligate anaerobic, non-spore-forming bacteria (family Bacteroidaceae) containing gram-negative rods. (thefreedictionary.com)
  • Aliivibrio Infections 0 domande Infections with bacteria of the genus ALIIVIBRIO. (lookformedical.com)
  • Brucellosi 0 domande Infection caused by bacteria of the genus BRUCELLA mainly involving the MONONUCLEAR PHAGOCYTE SYSTEM. (lookformedical.com)
  • Infezioni Da Helicobacter 0 domande Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. (lookformedical.com)
  • The B. fragilis group is the species of Bacteroidaceae isolated with greatest frequency in clinical specimens. (definitions.net)
  • It is the most common species of anaerobic bacteria isolated from human soft tissue infections. (definitions.net)
  • 16 rRNA gene sequencing analysis identified Clostridiales , Bacteroidaceae , and Lactobacillaceae species as the most abundant species in the gut. (asm.org)
  • Some species ( B. fragilis , for example) are opportunistic human pathogens, causing infections of the peritoneal cavity, gastrointestinal surgery, and appendicitis via abscess formation, inhibiting phagocytosis , and inactivating beta-lactam antibiotics . (bionity.com)
  • 3 Acinetobacter species also cause nosocomial pneumonia, skin and soft tissue infections, meningitis, bactermia and urinary tract infections. (thefreedictionary.com)
  • A third species of filamentous fermentative Gram-positive bacteria, Propionibacterium propionicum (formerly Arachnia propionicum ), is a much less common cause of actinomycotic infections (Table 1). (enetmd.com)
  • Although B. fragilis is the most common species of anaerobic bacteria isolated from human soft tissue infections and anaerobic bacteremia, it accounts for less than 1% of the normal human intestinal flora. (hardydiagnostics.com)
  • Infections with bacteria of the family ENTEROBACTERIACEAE. (sickkids.ca)
  • Porphyromonas sp se aisló en el mismo medio con el agregado de bacitracina y colistina. (bvsalud.org)
  • The local destruction of periodontitis is believed to result from a bacterial infection of the gingival sulcus, and several clinical studies have provided evidence to implicate Porphyromonas gingivalis . (asm.org)
  • We recently reported that the innate immune recognition receptor, Toll-like receptor 2 (TLR2), is crucial for inflammatory bone loss in response to infection by Porphyromonas gingivalis , the primary organism associated with chronic inflammatory periodontal disease. (asm.org)
  • Antibodies to Porphyromonas gingivalis Indicate Interaction Between Oral Infection, Smoking, and Risk Genes in Rheumatoid Arthritis Etiology. (ox.ac.uk)
  • These gut taxa contribute to the intestinal dysbiosis associated with C. difficile infection. (frontiersin.org)
  • We found that four communities were able to significantly reduce the severity of the initial C. difficile infection and limit susceptibility to disease relapse. (asm.org)
  • Overall, the insights gained through the identification and characterization of these simplified communities increase our understanding of the microbial dynamics of C. difficile infection and recovery. (asm.org)
  • El objetivo de este trabajo fue establecer la prevalencia de Prevotella spp y Porphyromona spp en los distintos estadios de periodontitis crónicas. (bvsalud.org)
  • Increased inflammatory reaction of patients with periodontitis was a possible factor, which connected periodontal infection and vascular diseases.We assessed medical history, blood data, and periodontal conditions in patients with cardiovascular diseases. (bvsalud.org)
  • Our data on sequence similarity and cross-reactivity with bacterial enolase may indicate a role for bacterial infection, particularly with P gingivalis, in priming autoimmunity in a subset of patients with RA. (nih.gov)
  • In this study, we demonstrate that P. gingivalis infection of HAEC resulted in the rapid cleavage of receptor interacting protein 1 (RIPK1), a mediator of tumor necrosis factor (TNF) receptor-1 (TNF-R1)-induced cell activation or death, and RIPK2, a key mediator of both innate immune signaling and adaptive immunity. (nih.gov)
  • We propose that knockout of these ivi genes reduced the ability of the mutated P. gingivalis to survive and cause infection compared to the wild-type strain at the site of injection. (asm.org)
  • This is particularly true of P. gingivalis , for which the chemical and physical properties of actual infection of the natural host are still largely unknown. (asm.org)
  • These results demonstrate that macrophage-dependent TLR2 signaling is crucial for TNF-α-dependent/RANKL-independent osteoclastogenesis in response to P. gingivalis infection. (asm.org)
  • We aimed to conduct a preliminary exploration of the underlying mechanism of P. gingivalis infection in the development of NAFLD. (bvsalud.org)
  • This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease. (lookformedical.com)
  • In recent years, the widespread use of antibiotics has resulted in the rapid growth of antibiotic-resistant microorganisms that often induce critical infection and pathogenesis. (elsevier.com)
  • Of the three large groups that compose the phylum, the family Bacteroidaceae typically is found in the intestinal tracts and mucous membranes of warm-blooded animals, including humans. (gopetsamerica.com)
  • Infezioni Da Fusobacteriaceae 0 domande Infections with bacteria of the family Fusobacteriaceae, in the order Fusobacterales, phylum FUSOBACTERIA. (lookformedical.com)
  • Abbas Abdel Aziz , Post-operative wound infection caused by bacteroidaceae family, New Egypt. (who.int)
  • In a previous study we conducted ( 13 ), contrary to this report, none of 32 clinical isolates belonging to the family Bacteroidaceae obtained over a 5-year period were resistant to metronidazole. (cdc.gov)
  • Infections with bacteria of the family PISCIRICKETTSIACEAE, causing septicemic disease of salmonid fish (SALMONIDAE). (umassmed.edu)
  • Infezioni Da Anaplasmataceae 0 domande Infections with bacteria of the family ANAPLASMATACEAE. (lookformedical.com)
  • It belongs to the family of Bacteroidaceae . (biomedcentral.com)
  • Nor are the fecal bacteria so bad;generally speaking they're part of the family Bacteroidaceae, and are nothing more than gut bacteria that took the long, strange trip to the outside world. (gizmodo.com)
  • nov., in the family Bacteroidaceae. (springer.com)
  • Sequencing of cell-sorted fractions reveals members of the underexplored family Muribaculaceae as major mucin monosaccharide foragers, followed by members of Lachnospiraceae, Rikenellaceae, and Bacteroidaceae families. (nature.com)
  • Cell morphology varies greatly within the family Bacteroidaceae. (hardydiagnostics.com)
  • Human actinomycoses are always synergistic polymicrobial infections in which fermentative actinomycetes-predominantly Actinomyces israelii , A. gerencseriae , or Propionibacterium propionicum -are the principal pathogens, usually needing the assistance of so-called concomitant microbes to produce disease. (enetmd.com)
  • Pseudomonas Infections" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • Protease activity sensors noninvasively classify bacterial infections and antibiotic responses. (harvard.edu)
  • El factor etiológico esencial en la patología inflamatoria periodontal es la biopelícula dental y cuando el desequilibrio entre el huésped y los microorganismos cambia la complejidad de la flora. (bvsalud.org)
  • El estado periodontal se clasificó en distintos grados de severidad: leve, moderada y severa. (bvsalud.org)
  • Periodontal diseases comprise a group of infections affecting the periodontium, including the gingiva, gingival attachment, periodontal ligament, cementum, and supporting alveolar bone. (asm.org)
  • Although C. jejuni infection has been shown to promote intestinal inflammation, the impact of this bacterium on carcinogenesis has never been examined. (bmj.com)
  • C. jejuni infection has been shown to promote intestinal inflammation. (bmj.com)
  • Background: Gastrointestinal lymphoid tissue is the main human T-cell reservoir and depletion of intestinal CD4+ T cells following HIV infection leads to persisting mucosal barrier disfunction, increased gut permeability and microbial translocation even among HIV-infected patients on suppressive antiretroviral treatment. (usp.br)
  • Men who have sex with men (MSM) have differences in immune activation and gut microbiome composition compared with men who have sex with women (MSW), even in the absence of HIV infection. (newsreportsite.org)
  • Recent studies have reported a distinct gut microbiome composition in men who have sex with men (MSM) exhibiting HIV-risk behaviors when compared with low-risk men who have sex with women (MSW), regardless of their HIV infection status. (newsreportsite.org)
  • Severe infection may result from the invasion of the bacillus through a break in the mucous membrane into the venous circulation, where thrombosis and bacteremia may occur. (thefreedictionary.com)
  • Associations with demographics, urinary symptoms, urinary tract infection risk, and treatment outcomes were determined. (cdc.gov)
  • Fournier gangrene is usually secondary to perirectal or periurethral infections associated with local trauma, operative procedures, or urinary tract disease. (lookformedical.com)
  • They're more likely to be resistant to antibiotics and more likely to cause medical problems from urinary tract infections to meningitis. (gizmodo.com)
  • Anaerobic or mixed infections result from disruption of mucosal surfaces and introduction of anaerobes into a normally sterile sight. (hardydiagnostics.com)
  • These bacteria competes with other microorganisms in the lumen for nutrients and food which in turn beneficial to human body since it decreases the availability of nutrients for some dangerous pathogenic organisms to grow causing harmful infections. (biology-online.org)
  • Predisposing factors include surgical procedures, trauma, peripheral vascular disease, carcinomas and prior infection with facultative organisms. (hardydiagnostics.com)
  • En el total de pacientes se determinó la presencia de Prevotella spp en el 54% de los casos y un 12,5% de Porphyromona spp. (bvsalud.org)
  • B. fragilis is involved in 90% of anaerobic peritoneal infections. (wikipedia.org)
  • however, it is not routinely quantified in patients with extremely serious infections, particularly in cases with no history or evidence of immunocompromising disorders. (bireme.br)
  • Nearly all of the members of the mixed actinomycotic microflora belong to the indigenous microbial community of human mucous membranes, hence actinomycoses present as sporadic endogenous infections which are not transmissible. (enetmd.com)
  • 1) hamster mammilla was different from another rodent, for example Castaneus, 2) nursing behavior of infants was also different from another rodents, 3) the component of hamster milk resembled swine and cat, 4) bacterial flora consisted of Bacteroidaceae, Gream positive anaerobic cocci, Lactobacilli, et al. (nii.ac.jp)
  • Men who have sex with men (MSM) comprise over half of all people living with HIV in the United States and accounted for 67% of new U.S. infections in 2016 [ 1 ]. (newsreportsite.org)
  • Lackraj T, Johnson-Henry K, Sherman PM, Goodman SD, Segall AM, Barnett Foster D. Novel antimicrobial peptide prevents C. rodentium infection in C57BL/6 mice by enhancing acid-induced pathogen killing. (sickkids.ca)
  • The selective advantage of these commensal microbes to occupy niches in the gastrointestinal tract helps to explain the success of FMT to reconstitute the gut microbe community of patients with recurrent C. difficile infections. (beds.ac.uk)
  • 6 , 7 However, in children and perhaps adults, the infection frequently seems to be polymicrobial. (aappublications.org)
  • Why are sickle-cell patients particularly prone to Salmonella osteomyelitis and other infections? (cueflash.com)
  • As regards postoperative wound infection, twenty five of them were associated with appendicecomy. (who.int)
  • Pathogenic bacteria have the ability to modulate the expression of genes in response to continually changing conditions during the course of infection. (asm.org)
  • CONCLUSION: Our results suggest that wAlbB infection of arthropods could be used to reduce transmission of a wide range of pathogenic RNA viruses. (bvsalud.org)
  • Since pathogenic Brucella survive and replicate inside phagocytes, cellular models of infection constitute important tools in brucellosis research. (bvsalud.org)
  • This graph shows the total number of publications written about "Pseudomonas Infections" by people in Harvard Catalyst Profiles by year, and whether "Pseudomonas Infections" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Pseudomonas Infections" by people in Profiles. (harvard.edu)
  • List the important Pseudomonas infections? (cueflash.com)
  • The patient was in good physical condition with aggressive fits, co-operative and orientated when awake and conscious and showed no signs of acute infection apart from an elevated C-reactive protein (61.6 mg/l) and leukocytes (21.6 G/l). (biomedcentral.com)
  • During infection it is implicated in abscess formation wherein this bacterium formed a fibrous membrane surrounding the infected site and if left untreated can caused major damage in human and animals. (biology-online.org)
  • Anaerobic infection is characterized by abscess formation and tissue destruction. (hardydiagnostics.com)
  • These potentially lethal infections are difficult to recognize in early stages and are often associated with predisposing factors like diabetes and immunocompromised states. (bireme.br)
  • it has been demonstrated that invasive streptococcus A infections can trigger a toxic shock syndrome, myositis, or destroy the sheath that covers the muscle, necrotizing fasciitis. (fpnotebook.com)