Bordetella pertussis: A species of gram-negative, aerobic bacteria that is the causative agent of WHOOPING COUGH. Its cells are minute coccobacilli that are surrounded by a slime sheath.Virulence Factors, Bordetella: A set of BACTERIAL ADHESINS and TOXINS, BIOLOGICAL produced by BORDETELLA organisms that determine the pathogenesis of BORDETELLA INFECTIONS, such as WHOOPING COUGH. They include filamentous hemagglutinin; FIMBRIAE PROTEINS; pertactin; PERTUSSIS TOXIN; ADENYLATE CYCLASE TOXIN; dermonecrotic toxin; tracheal cytotoxin; Bordetella LIPOPOLYSACCHARIDES; and tracheal colonization factor.Pertussis Vaccine: A suspension of killed Bordetella pertussis organisms, used for immunization against pertussis (WHOOPING COUGH). It is generally used in a mixture with diphtheria and tetanus toxoids (DTP). There is an acellular pertussis vaccine prepared from the purified antigenic components of Bordetella pertussis, which causes fewer adverse reactions than whole-cell vaccine and, like the whole-cell vaccine, is generally used in a mixture with diphtheria and tetanus toxoids. (From Dorland, 28th ed)Bordetella: A genus of gram-negative, aerobic bacteria whose cells are minute coccobacilli. It consists of both parasitic and pathogenic species.Bordetella Infections: Infections with bacteria of the genus BORDETELLA.Bordetella bronchiseptica: A species of BORDETELLA that is parasitic and pathogenic. It is found in the respiratory tract of domestic and wild mammalian animals and can be transmitted from animals to man. It is a common cause of bronchopneumonia in lower animals.Virulence: The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.Whooping Cough: A respiratory infection caused by BORDETELLA PERTUSSIS and characterized by paroxysmal coughing ending in a prolonged crowing intake of breath.Bordetella parapertussis: A species of BORDETELLA with similar morphology to BORDETELLA PERTUSSIS, but growth is more rapid. It is found only in the RESPIRATORY TRACT of humans.Pertussis Toxin: One of the virulence factors produced by BORDETELLA PERTUSSIS. It is a multimeric protein composed of five subunits S1 - S5. S1 contains mono ADPribose transferase activity.Virulence Factors: Those components of an organism that determine its capacity to cause disease but are not required for its viability per se. Two classes have been characterized: TOXINS, BIOLOGICAL and surface adhesion molecules that effect the ability of the microorganism to invade and colonize a host. (From Davis et al., Microbiology, 4th ed. p486)Hemagglutinins: Agents that cause agglutination of red blood cells. They include antibodies, blood group antigens, lectins, autoimmune factors, bacterial, viral, or parasitic blood agglutinins, etc.Adenylate Cyclase Toxin: One of the virulence factors produced by virulent BORDETELLA organisms. It is a bifunctional protein with both ADENYLYL CYCLASES and hemolysin components.Bordetella avium: A species of BORDETELLA isolated from the respiratory tracts of TURKEYS and other BIRDS. It causes a highly contagious bordetellosis.Bacterial Proteins: Proteins found in any species of bacterium.Bacteria: One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.Gene Expression Regulation, Bacterial: Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria.Adhesins, Bacterial: Cell-surface components or appendages of bacteria that facilitate adhesion (BACTERIAL ADHESION) to other cells or to inanimate surfaces. Most fimbriae (FIMBRIAE, BACTERIAL) of gram-negative bacteria function as adhesins, but in many cases it is a minor subunit protein at the tip of the fimbriae that is the actual adhesin. In gram-positive bacteria, a protein or polysaccharide surface layer serves as the specific adhesin. What is sometimes called polymeric adhesin (BIOFILMS) is distinct from protein adhesin.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Bacterial Outer Membrane Proteins: Proteins isolated from the outer membrane of Gram-negative bacteria.Antibodies, Bacterial: Immunoglobulins produced in a response to BACTERIAL ANTIGENS.

*Filamentous haemagglutinin adhesin

One notable bacterium that produces filamentous hæmagglutinin adhesin is Bordetella pertussis, which uses this protein as a ... virulence factor.. ... filamentous protein that serves as a dominant attachment factor ...

*Pertactin

... is a highly immunogenic virulence factor of Bordetella pertussis, the bacterium that causes pertussis. Specifically, it is an ... Emsley, P.; Charles, I. G.; Fairweather, N. F.; Isaacs, N. W. (1996). "Structure of Bordetella pertussis virulence factor P.69 ... Emsley P, Charles IG, Fairweather NF, Isaacs NW (May 1996). "Structure of Bordetella pertussis virulence factor P.69 pertactin ... PRN is purified from Bordetella pertussis and is used for the vaccine production as one of the important components of ...

*Teresa Lagergård

Main focus was on such bacteria as Haemophilus influenzae, H. ducreyi, and Streptococcus sp. Bordetella pertussis 1. She was a ... Her main field of research include investigation of bacterial virulence factors, mechanisms of infection, infections immunology ...

*Bordetella pertussis

Unlike B. bronchiseptica, B. pertussis is not motile. Its virulence factors include pertussis toxin, filamentous hæmagglutinin ... B. pertussis infects its host by colonizing lung epithelial cells. The bacterium contains a surface protein, filamentous ... 16: Pertussis Parkhill J, et al. (2003). "Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella ... Bordetella pertussis is a Gram-negative, aerobic, pathogenic, encapsulated coccobacillus of the genus Bordetella, and the ...

*Bordetella

"Phosphorylated BvgA is sufficient for transcriptional activation of virulence-regulated genes in Bordetella pertussis". EMBO J ... Other bacteria recycle this molecule back into the cytoplasm, but in Bordetella and Neisseria gonorrhoeae, it is released into ... In these conditions, some, but not all of the virulence factors associated with the Bvg+ phase are expressed, suggesting this ... and Clinical Manifestations of Respiratory Infections Due to Bordetella pertussis and Other Bordetella Subspecies". Clin ...

*LuxR-type DNA-binding HTH domain

Bordetella pertussis bvgA (virulence factor) Bacillus subtilis comA (involved in expression of late-expressing competence genes ... which are used as quorum sensing molecules in a variety of Gram-negative bacteria: Vibrio fischeri luxR (activates ... virulence factor for soft rot disease; activates plant tissue macerating enzyme genes) Pseudomonas aeruginosa lasR (activates ... "Structure of a bacterial quorum-sensing transcription factor complexed with pheromone and DNA". Nature. 417 (6892): 971-4. doi: ...

*Exotoxin

Another example is Pertussis toxin. These "toxins" allow the further spread of bacteria and, as a consequence, deeper tissue ... They are often referred to as virulence factors, since they allow the organisms to move deeper into the hosts tissues. ... DPT vaccine protects against pertussis, tetanus and diphtheria infections, caused by the exotoxin-producing Bordetella ... D'Auria G, Jiménez N, Peris-Bondia F, Pelaz C, Latorre A, Moya A (2008). "Virulence factor rtx in Legionella pneumophila, ...

*Bordetella bronchiseptica

B. bronchiseptica does not express pertussis toxin, which is one of the characteristic virulence factors of B. pertussis, but ... Bordetella bronchiseptica is a small, Gram-negative, rod-shaped bacterium of the genus Bordetella. It can cause infectious ... Diavatopoulos DA, Cummings CA, Schouls LM, Brinig MM, Relman DA, Mooi FR (2005). "Bordetella pertussis, the Causative Agent of ... Closely related to B. pertussis-the obligate human pathogen that causes pertussis (whooping cough); B. bronchiseptica can ...

*Secretion

Bordetella pertussis, the causative agent of whooping cough, secretes the pertussis toxin partly through the type IV system. ... Additionally, T4SS also secrete virulence factor proteins directly into host cells as well as taking up DNA from the medium ... Secretion is not unique to eukaryotes alone - it is present in bacteria and archaea as well. ATP binding cassette (ABC) type ... Vesicles from a number of bacterial species have been found to contain virulence factors, some have immunomodulatory effects, ...

*RTX toxin

Adenylate cyclase toxin (ACT or CyaA), is a primary virulence factor in Bordetella pertussis. CyaA is a multifunctional RTX ... This mode of transport increases virulence by aiding in EHEC-Hly delivery to target cells. RTX toxins in Vibrio bacteria ... are the primary virulence factors in enterohaemorrhagic E. coli but EHEC produces several other virulence factors capable of ... RtxA is a virulence factor involved in cholera which facilitates colonization of V. cholerae the small intestine. RtxA causes ...

*Bacterial adhesin

This prevalence marks them as key microbial virulence factors in addition to a bacterium's ability to produce toxins and resist ... Moreover, the Bordetella pertussis adhesins FHA and pertactin are components of three of the four acellular pertussis vaccines ... Identified Virulence Factors of UPEC : Adherence, State Key Laboratory for Moleclular Virology and Genetic Engineering, Beijing ... The majority of bacterial pathogens exploit specific adhesion to host cells as their main virulence factor. "A large number of ...

*Pertussis

... is caused by the bacterium Bordetella pertussis. It is an airborne disease which spreads easily through the coughs ... have already been infected for several weeks to determine whether antibody against pertussis toxin or another virulence factor ... Pertussis is caused by the bacterium Bordetella pertussis. It is an airborne disease which spreads easily through the coughs ... The bacterium that causes the infection was discovered in 1906. The pertussis vaccine became available in the 1940s. Play media ...

*Whooping cough

"Pertussis toxin and adenylate cyclase toxin: key virulence factors of Bordetella pertussis and cell biology tools". Future ... Pertussis is caused by the bacterium Bordetella pertussis.[4] It is an airborne disease which spreads easily through the coughs ... Pertussis is caused by the bacterium Bordetella pertussis. It is an airborne disease (through droplets) that spreads easily ... filamentous strep throat and leukocytosis-promoting-factor HA), which are secreted by B. pertussis. Sato's acellular pertussis ...

*CyaA

Both are virulence factors facilitating respiratory tract colonization by B. pertussis. The cyaA-ACD binds to a M2 integrin ... "Pertussis toxin and adenylate cyclase toxin provide a one-two punch for establishment of Bordetella pertussis infection of the ... Bifunctional hemolysin/adenylate cyclase is a protein that in B. pertussis (the bacteria that causes whooping cough) is encoded ... "The adenylate cyclase toxin of Bordetella pertussis binds to target cells via the alpha(M)beta(2) integrin (CD11b/CD18)". J. ...

*Bacillus anthracis

It is one of few bacteria known to synthesize a protein capsule (poly-D-gamma-glutamic acid). Like Bordetella pertussis, it ... and other virulence factors. The enterotoxins and virulence factors are encoded on the chromosome, while the emetic toxin is ... lethal factor, LF), and cya (edema factor, EF). These factors are contained within a 44.8-kb pathogenicity island (PAI). The ... While B. cereus and B. thuringiensis depend on the plcR gene for expression of their virulence factors, B. anthracis relies on ...

*Secretion

Bordetella pertussis, the causative agent of whooping cough, secretes the pertussis toxin partly through the type IV system. ... Additionally, T4SS also secrete virulence factor proteins directly into host cells as well as taking up DNA from the medium ... It is like a molecular syringe through which a bacterium (e.g. certain types of Salmonella, Shigella, Yersinia, Vibrio) can ... Vesicles from a number of bacterial species have been found to contain virulence factors, some have immunomodulatory effects, ...

*Cholera toxin

The pertussis toxin (also an AB5 protein) produced by Bordetella pertussis acts in a similar manner with the exception that it ... CTA1 is then free to bind with a human partner protein called ADP-ribosylation factor 6 (Arf6); binding to Arf6 drives a change ... Davis B, Waldor M (2003). "Filamentous phages linked to virulence of Vibrio cholerae". Curr Opin Microbiol. 6 (1): 35-42. doi: ... and sequence to the heat-labile enterotoxin secreted by some strains of the Escherichia coli bacterium. Cholera toxin acts by ...

*AB5 toxin

Carbonetti, N. H. (2010). "Pertussis toxin and adenylate cyclase toxin: Key virulence factors of Bordetella pertussis and cell ... Pertussis toxin is secreted by the gram-negative bacterium, Bordetella pertussis. Whooping cough is very contagious and cases ... The bacterium Bordetella pertussis was first identified as the cause of whooping cough and isolated by Jules Bordet and Octave ... Guiso N. 2009.Bordetella pertussis and pertussis vaccines. Clin. Infect. Dis. 49:1565-1569 Faruque, S. M.; Chowdhury, N; Khan, ...

*Pertussis toxin

Carbonetti NH (2010). "Pertussis toxin and adenylate cyclase toxin: key virulence factors of Bordetella pertussis and cell ... Pertussis toxin (PT) is a protein-based AB5-type exotoxin produced by the bacterium Bordetella pertussis, which causes whooping ... pertussis produces PT and the other species do not. Bordetella parapertussis shows the most similarity to B. pertussis and was ... "Pertussis Toxin Plays an Early Role in Respiratory Tract Colonization by Bordetella pertussis". Infect. Immun. 71 (11): 6358-66 ...

*Neisseria meningitidis

Other virulence factors include a polysaccharide capsule which prevents host phagocytosis and aids in evasion of the host ... The bacterium is referred to as a coccus because it is round, and more specifically, diplococcus because of its tendency to ... Bordetella pertussis/Bordetella parapertussis *Pertussis. γ. Enterobacteriales. (OX−). Lac+. *Klebsiella pneumoniae * ... Porins are also recognized by TLR2, they bind complement factors (C3b, C4b, factor H, and C4bp (complement factor 4b-binding ...

*Cholera

When consumed, most bacteria do not survive the acidic conditions of the human stomach.[26] The few surviving bacteria conserve ... Selective pressures exist however in the aquatic environment that may reduce the virulence of V. cholerae.[21] Specifically, ... "Sources of Infection & Risk Factors". Centers for Disease Control and Prevention. November 7, 2014. Archived from the original ... Bordetella pertussis/Bordetella parapertussis *Pertussis. γ. Enterobacteriales. (OX−). Lac+. *Klebsiella pneumoniae * ...

*Vaccine

The 'a' in DTaP and Tdap stands for 'acellular,' meaning that the pertussis component contains only a part of the pertussis ... a recombinant protein derived from the viruses or bacteria can be generated in yeast, bacteria, or cell cultures. After the ... assorted factors such as ethnicity, age, or genetic predisposition. If a vaccinated individual does develop the disease ... such as Bordetella bronchiseptica, has likely increased in recent years. In some cases, most notably rabies, the parallel ...

*Vaccine

The 'a' in DTaP and Tdap stands for 'acellular,' meaning that the pertussis component contains only a part of the pertussis ... a recombinant protein derived from the viruses or bacteria can be generated in yeast, bacteria, or cell cultures. After the ... Lack of response commonly results from clinical factors such as diabetes, steroid use, HIV infection, or age.[citation needed] ... such as Bordetella bronchiseptica, has likely increased in recent years.[104] In some cases, most notably rabies, the parallel ...
Bordetella pertussis adenylate cyclase. Penetration into host cells.: Exposure of Chinese hamster ovary, mouse adrenal cortex tumor (Y-1), THP-1 and U-937 cells
The Sanger Institute has been funded by the Wellcome Trust to sequence the genomes of Bordetella pertussis strain Tohama I, B. parapertussis strain 12822 and B. bronchiseptica strain RB50 in collaboration with Duncan Maskell and Andrew Preston of the Centre for Veterinary Science, Dept. of Clinical Veterinary medicine, The University of Cambridge. The sequences and analysis are described in: Parkhill et al (2003) Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica. Nature Genetics 35 32-40 (DOI: 10.1038/Ng1227), and have been submitted to EMBL/GenBank with the accession numbers: BX470248 (B. pertussis), BX470249 (B. parapertussis) and BX470250 (B. bronchiseptica). The three sequenced ...
The effect of an i.p. injection of Bordetella pertussis on the primary humoral immune response in mice to the thymus-independent antigen SIII has been studied. Suppression of the antibody response occurred when pertussis cells were injected at the same time as an optimal immunizing dose of SIII. In contrast, the antibody response to high doses of SIII was enhanced by B. pertussis.. When SIII alone was injected, only 19S antibody was detected. However, when B. pertussis was administered with either optimal or high doses of SIII, 7S as well as 19S antibody against SIII was produced.. ...
Bordetella pertussis isolates that do not express pertactin (PRN) are increasing in regions where acellular pertussis vaccines have been used for >7 years. We analyzed data from France and compared clinical symptoms among infants <6 months old infected by PRN-positive or PRN-negative isolates. No major clinical differences were found between the 2 groups.
Bordetella pertussis is the causative agent of human whooping cough (pertussis) and is particularly severe in infants. Despite worldwide vaccinations, whooping cough remains a public health problem. A significant increase in the incidence of whooping cough has been observed in many countries since the 1990s. Several reasons for the re-emergence of this highly contagious disease have been suggested. A particularly intriguing possibility is based on evidence indicating that pathogen adaptation may play a role in this process. In an attempt to gain insight into the genomic make-up of B. pertussis over the last 60 years, we used an oligonucleotide DNA microarray to compare the genomic contents of a collection of 171 strains of B. pertussis isolates from different countries. The CGH microarray analysis estimated the core genome of B. pertussis, to consist of 3,281 CDSs that are conserved among ...
Morse, J.H.; Kong, A.S.; Lindenbaum, J.; Morse, S.I., 1977: The mitogenic effect of the lymphocytosis promoting factor from Bordetella pertussis on human lymphocytes
The effect of exogenously added adenylate cyclase from Bordetella pertussis (strain 114) has been investigated in Y-1 mouse adrenal tumor, chinese hamster ovary (CHO) and several other cells. A partially purified adenylate cyclase was found not to enter cells but, nevertheless, produced large amounts of cAMP in the medium. We could show that this resulted from release of ATP (and not larger molecules). The ATP released by the cells could be (1) directly measured and was replenished after each change of medium; (2) was reciprocally related to the cAMP produced; and (3) was competed for by ATPases present in added serum or by hexokinase and, less effectively, by exoenzymes on the cell surface. The extent of ATP leakage varied widely between different cell lines, being marked in CHO and Y-1 adrenal cells but negligible in transformed lymphocyte lines. The uncertainty of the origin of cAMP found in media of cultured cells requires separate analysis of cell and ...
Since the 1980s, pertussis notifications in the United States have been increasing. To determine the types of Bordetella pertussis responsible for these increases, we divided 661 B. pertussis isolates collected in the United States during 1935-2009 into 8 periods related to the introduction of novel vaccines or changes in vaccination schedule. B. pertussis diversity was highest from 1970-1990 (94%) but declined to ≈ 70% after 1991 and has remained constant. During 2006-2009, 81.6% of the strains encoded multilocus sequence type prn2-ptxP3-ptxS1A-fim3B, and 64% were multilocus variable number tandem repeat analysis type 27. US trends were consistent with those seen internationally; emergence and predominance of the fim3B allele was the only molecular characteristic associated with the increase in pertussis notifications. Changes in the vaccine composition and schedule were not the direct ...
Acellular vaccines against Bordetella pertussis were introduced in Australia in 1997. By 2000, these vaccines had replaced whole-cell vaccines. During 2008-2012, a large outbreak of pertussis occurred. During this period, 30% (96/320) of B. pertussis isolates did not express the vaccine antigen pertactin (prn). Multiple mechanisms of prn inactivation were documented, including IS481 and IS1002 disruptions, a variation within a homopolymeric tract, and deletion of the prn gene. The mechanism of lack of expression of prn in 16 (17%) isolates could not be determined at the sequence level. These findings suggest that B. pertussis not expressing prn arose independently multiple times since 2008, rather than by expansion of a single prn-negative clone. All but 1 isolate had ptxA1, prn2, and ptxP3, the alleles representative of currently circulating strains in Australia. This pattern is consistent with continuing ...
Bordetella pertussis infection is being increasingly recognized as a cause of prolonged, distressing cough (without whooping symptoms) in children and young adults. Diagnosis of infection in this population is important for treatment and surveillance purposes, and may also prove useful in reducing transmission to unvaccinated babies, for whom disease can be fatal. Serum IgG titres against pertussis toxin (PT) are routinely used as a marker of recent or persisting B. pertussis infection. However, collection of serum from young children is difficult, and compliance amongst these subjects to give samples is low. To circumvent these problems, an IgG-capture ELISA capable of detecting anti-PT IgG in oral fluid was devised. The assay was evaluated by comparison to a serum ELISA, using 187 matched serum and oral fluid samples from children (aged 5-16 years) with a history of prolonged coughing, whose serum anti-PT titre had already ...
Gearing, A.J.; Bird, C.; Wadha, M.; Redhead, K., 1987: The primary and secondary cellular immune responses to whole cell Bordetella pertussis vaccine and its components
The effect of an extract of histamine-sensitizing factor (HSF) of Bordetella pertussis on the immune response of different strains of mice to ovalbumin (OA) was investigated with regard to optimal dose of antigen and adjuvant. It was observed that all strains of mice treated with HSF during immunization with OA demonstrated enhanced production of hemagglutinating antibodies, as compared to animals treated with antigen alone. This enhancement was generally not as great as that demonstrated when Al(OH)3 was the adjuvant. HSF also stimulated a reaginic antibody response (IgE) to OA, but not in all strains of mice. In reagin responders optimal responses were observed with high doses of both antigen and adjuvant, whereas low doses of both produced little or no response. Maximal reagin production occurred usually 14-28 days after immunization and persisted for long periods of time. An anamnestic reagin response was elicited upon secondary immunization with antigen ...
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Adenylate cyclase toxin (CyaA) from Bordetella pertussis can subvert host immune responses allowing bacterial colonization. Here we have examined its adjuvant and immunomodulatory properties and the possible contribution of lipopolysaccharide (LPS), known to be present in purified CyaA preparations. CyaA enhanced antigen-specific interleukin-5 (IL-5) and IL-10 production and immunoglobulin G1 antibodies to coadministered antigen in vivo. Antigen-specific CD4+-T-cell clones generated from mice immunized with antigen and CyaA had cytokine profiles characteristic of Th2 or type 1 regulatory T (Tr1) cells. Since innate immune cells direct the induction of T-cell subtypes, we examined the influence of CyaA on activation of dendritic cells (DC) and macrophages. CyaA significantly augmented LPS-induced IL-6 and IL-10 and inhibited LPS-driven tumor necrosis factor alpha and IL-12p70 production from bone marrow-derived DC and macrophages. CyaA also enhanced cell ...
Pertussis Vaccine: A suspension of killed Bordetella pertussis organisms, used for immunization against pertussis (WHOOPING COUGH). It is generally used in a mixture with diphtheria and tetanus toxoids (DTP). There is an acellular pertussis vaccine prepared from the purified antigenic components of Bordetella pertussis, which causes fewer adverse reactions than whole-cell vaccine and, like the whole-cell vaccine, is generally used in a mixture with diphtheria and tetanus toxoids. (From Dorland, 28th ed)
Using antisera raised against serotype 2 and 3 fimbrial subunits from Bordetella pertussis, serologically related polypeptides were detected in Bordetella bronchiseptica, Bordetella parapertussis and Bordetella avium strains. The two B. pertussis fimbrial subunits, and three of the serologically related B. bronchiseptica polypeptides, were shown to be very similar in amino ... read more acid composition and N-terminal amino acid sequence. Homology was observed between the N-termini of these polypeptides, and fimbrial subunits from Escherichia coli, Haemophilus influenzae and Proteus mirabilis. A synthetic oligonucleotide probe, derived from the N-terminal sequence of the B. pertussis serotype 2 fimbrial subunit, was used to identify fimbrial genes in genomic Southern blots. The results suggested the presence ...
Since their introduction in the 1940s and 1950s, pertussis vaccines (mostly in combination with diphtheria and tetanus toxoids as diphtheria, tetanus, and pertussis vaccines) have been very efficient in reducing pertussis mortality and morbidity in infants and young children. WHO estimates suggest that between 1999 and 2014, more than 100 000 infant deaths could have been averted mainly by increased coverage of pertussis vaccination.1 Pertussis vaccines come in two varieties: one is made of whole-cell killed Bordetella pertussis cells, consequently called whole-cell pertussis vaccine, and the other is made from one to five purified and partly chemically inactivated bacterial virulence factors, consequently called acellular pertussis vaccine. ...
The adenylate cyclase toxin (AC toxin) is necessary for disease caused by Bordetella pertussis, which has reemerged in the United States over the last two decad...
Bordetella parapertussis ATCC ® 15311D-5™ Designation: Genomic DNA from Bordetella parapertussis Strain 522 TypeStrain=True Application:
Bordetella parapertussis: | | | | |Bordetella parapertussis| | | ... World Heritage Encyclopedia, the aggregation of the largest online encyclopedias available, and the most definitive collection ever assembled.
Despite an increased proportion of Bordetella pertussis isolates lacking pertactin, vaccine effectiveness (VE) is still high in Vermont for the five-dose diphtheria, tetanus, and acellular pertussis vaccine (DTaP) series and the tetanus, diphtheria, and acellular pertussis vaccine (Tdap).
Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.
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Coloured scanning electron micrograph (SEM) of Bordetella bronchiseptica, Gram-negative, aerobic, motile, coccobacillus prokaryote (bacterium). Bordetella bronchiseptica typically infects the respiratory tracts of smaller mammals (cats, dogs, rabbits). It causes infectious bronchitis, but rarely infects humans. It does not express pertussis toxin, which is one of the characteristic virulence factors of B. pertussis. It is related to Bordetella pertussis, the obligate human pathogen, that causes pertussis or whooping cough. B. bronchiseptica does not express pertussis toxin, which is one of the characteristic virulence factors of B. pertussis. Humans are not natural carriers of B. bronchiseptica. Magnification: x4,400 when ...
Swelling involving the entire thigh or upper arm has been reported after booster doses of different acellular pertussis vaccines. Swelling of the entire thigh was reported among recipients of a booster dose of JNIH-6 (a two-component acellular pertussis vaccine produced by Biken [Japan] and comparable to the acellular pertussis component contained in Tripedia). During a study performed in Sweden during the 1980s, children who had previously received two or three doses of Biken acellular pertussis vaccine at age 6--8 months received a booster dose deep subcutaneously of the same vaccine at age 2 years. Certain children experienced substantial local reactions, including swelling of the entire thigh (16), although administration of vaccine subcutaneously could have influenced reaction rates in that study. Occurrence of extensive swelling involving the entire thigh of vaccinated children was reported among DTaP recipients in an open-label safety ...
Reassessment of the role of whole-cell pertussis vaccine as a cause of permanent neurologic damage is necessitated by the 10-year follow-up of the National Childhood Encephalopathy Study (NCES) in Great Britain. The findings of this study demonstrate that infants and young children with serious acute neurologic disorders are at an increased risk of later neurologic impairment or death, irrespective of the initial precipitating event. The results, however, do not establish a causal relationship between pertussis vaccination and chronic neurologic abnormalities. The Academy reaffirms its earlier conclusion that whole-cell pertussis vaccine has not been proven to be a cause of brain damage and continues to recommend pertussis vaccination in accordance with the guidelines in the 1994 Red Book.. ...
TY - JOUR. T1 - Effect of adenosine and pertussis vaccine on lymphocyte response in vitro to phytohemmaglutinin in asthmatic and non-asthmatic subjects. AU - Hiratani, M.. AU - McCall, M. K.. AU - Chaperon, E. A.. AU - Townley, R. G.. PY - 1988/1/1. Y1 - 1988/1/1. N2 - Adenosine and pertussis vaccine each significantly suppresed the in vitro lymphocyte response to photohemagglutinin (PHA) in both asthmatic and non-asthmatic subjects. On the other hand, pertussis vaccine significantly enhanced the response of the lymphocytes treated with a lower concentration of adenosine both in asthmatic and non-asthmatic subjects. It was also shown that lymphocytes from asthmatic and non-asthmatic subjects responded similarly to the modulating effect of adenosine and/or pertussis vaccine on PHA stimulation. These data give further evidence for the complex interplay of the vaccine with endogenous adenosine.. AB - Adenosine and pertussis ...
Bordetella is a genus of small (0.2 - 0.7 µm), Gram-negative coccobacilli of the phylum Proteobacteria. Bordetella species, with the exception of B. petrii, are obligate aerobes, as well as highly fastidious, or difficult to culture. All species can infect humans. The first three species to be described (B. pertussis, B. parapertussis, B. bronchiseptica,); are sometimes referred to as the classical species. One of these (B. bronchiseptica) is also motile. B. pertussis and occasionally B. parapertussis cause pertussis or whooping cough in humans, and some B. parapertussis strains can colonise sheep. B. bronchiseptica rarely infects healthy humans, though disease in immunocompromised patients has been reported. B. bronchiseptica causes several diseases in other mammals, including kennel cough and atrophic rhinitis in dogs and pigs, ...
MB Comment: There is a constant media barrage of stories urging everyone to get vaccinated against pertussis (whooping cough). Every such story castigates those who refuse the vaccine as endangering themselves and society by not vaccinating.. I previously ran an article discrediting that argument. The pertussis vaccine by definition is not bactericidal - it does not kill bacteria. Therefore, vaccinated individuals can carry and transmit pertussis bacteria just the same as the unvaccinated. Public health officials either dont know this or are being dishonest when they blame minor pertussis outbreaks on the unvaccinated. They could be carrying the germ themselves and personally transmitting it to the reporter when they plant these pseudo-scientific stories.. What else are they not telling you? I took a close look at the Sanofi Pasteur DTaP vaccine (Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Adsorbed) which ...
MB Comment: There is a constant media barrage of stories urging everyone to get vaccinated against pertussis (whooping cough). Every such story castigates those who refuse the vaccine as endangering themselves and society by not vaccinating.. I previously ran an article discrediting that argument. The pertussis vaccine by definition is not bactericidal - it does not kill bacteria. Therefore, vaccinated individuals can carry and transmit pertussis bacteria just the same as the unvaccinated. Public health officials either dont know this or are being dishonest when they blame minor pertussis outbreaks on the unvaccinated. They could be carrying the germ themselves and personally transmitting it to the reporter when they plant these pseudo-scientific stories.. What else are they not telling you? I took a close look at the Sanofi Pasteur DTaP vaccine (Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Adsorbed) which ...
ICD-10 A37.11 is whooping cough due to bordetella parapertussis with pneumonia (A3711). This code is grouped under diagnosis codes for certain infectious and parasitic diseases.
A37.11 ICD 10 CM Code for Whooping cough due to Bordetella parapertussis with pneumonia, Convert ICD 10 CM code A37.11 to ICD 9 CM code.
1ZBO: X-Ray Crystal Structure of Protein BPP1347 from Bordetella parapertussis. Northeast Structural Genomics Consortium Target BoR27.
PST receptors were purified and characterized in the liver, hepatoma membranes, as well as the signal transduction (55, 62, 63). This receptor appears to mediate the dual signaling mechanism in liver (57). PST stimulation activates pertussis toxin-insensitive G protein (Gαq/11), leading to the activation of phospholipase C b3 isoform (PLC-b3) (69), and therefore mediates the glycogenolytic effect in the liver by increasing cytoplasmic free calcium and stimulating PKC, while the pertussis toxin-sensitive G protein (Gai1,2) leads to the activation of guanylatecyclase (51). In the signaling pathway, hydrolysis of phosphatidylinositol 4,5-bisphosphate by Ca2+-mobilizing hormones leads to the formation of two second messengers i.e., inositol-1,4,5-triphosphate (InsP3) and diacylglycerol (DAG). The primary function of InsP3 is to mobilize Ca2+ from intracellular stores (60), whereas DAG stimulates PKC (58).. Active PST receptors were solubilized from rat liver membranes, and these ...
The study will be conducted by the University of Wisconsin School of Medicine and Public Health, in collaboration with the Wisconsin Division of Public Health (WDPH).. Epidemiological and laboratory surveillance for pertussis disease among Wisconsin residents is routinely conducted by the WDPH. During the period of the study, de-identified data regarding all incident pertussis cases will be obtained from WDPH and vaccination coverage rates, by vaccine regimen, age group, and period of time, will be obtained from ongoing marketplace surveillance conducted on behalf of the Sponsor by a national sample-survey organization. Using these data, rates of pertussis disease will be determined.. No vaccine will be administered as part of this study. ...
BLOT kit for the detection of specific IgG antibodies to the recombinant antigens of Bordetella pertussis and Bordetella parapertussis in human serum and plasma, for automated processing using the BlueDiver Instrument.
Easy to read patient leaflet for Diphtheria and Tetanus Toxoids, and Acellular Pertussis Vaccine. Includes indications, proper use, special instructions, precautions, and possible side effects.
Tetanus, diphtheria, and pertussis are serious diseases caused by bacteria.. Tetanus (lockjaw) causes painful tightening of the muscles, usually all over the body. It can lead to "locking" of the jaw so the victim cannot open the mouth or swallow. Tetanus leads to death in about 1 out of 10 cases.. Diphtheria causes a thick coating in the nose, throat, and airways. It can lead to breathing problems, paralysis, heart failure, or death.. Pertussis (whooping cough) causes coughing so severe that it interferes with eating, drinking, or breathing. These spells can last for weeks and can lead to pneumonia, seizures (convulsions), brain damage, and death.. Diphtheria and pertussis are spread from person to person. Tetanus enters the body through a cut or wound.. The diphtheria, tetanus acellular, and pertussis adult vaccine (also called Tdap) is used to help prevent these diseases in people who are at least 10 years old. Most people in this age ...
The European Pharmacopoeia (Ph. Eur.) Commission is seeking public feedback on its proposal to replace the Histamine sensitisation test in mice (HIST) with a standardised CHO cell clustering assay for residual pertussis toxin testing, in general chapter 2.6.33 Residual pertussis toxin and irreversibility of pertussis toxoid and in ten individual monographs on vaccines containing acellular pertussis.. Published in the April 2018 issue of Pharmeuropa, this consultation will run until June 2018. Interested parties are invited to provide their comments through the Procedure for commenting on Pharmeuropa drafts.. ...
|EM>Bordetella pertussis|/EM>, |EM>Bordetella parapertussis|/EM> and |EM>Bordetella bronchiseptica|/EM> are closely related Gram-negative Beta-proteobacteria that colonizes the respiratory tracts of mammals. |EM>B. parapertussis|/EM> causes whooping cough in a wide range of animals. D-Alanine is a necessary precursor in the biosynthesis of cell [...]
The quantitative determination of pertussis-toxin-sensitive guanine-nucleotide-binding proteins (G-proteins) in cell membranes is still a problem. Pertussis-toxin-catalysed [32P]ADP-ribosylation strongly relies on the substrate quality of the alpha-subunits and is influenced by the concentration of nucleotides, beta gamma-subunits, the physicochemical properties of the membranes influencing the availability of Gi alpha for pertussis toxin, and covalent modification of Gi alpha. Quantification of immunoreactive material on Western blots can be only imprecisely performed by two-dimensional densitometry. In order to generate a method for quantification of pertussis-toxin-sensitive G-proteins in membranes we have developed a fast and sensitive radioimmunoassay. The C-terminal decapeptide of retinal transducin alpha (KENLKDCGLF) was 125I-labelled and used as tracer. Polyclonal antiserum (DS 4) was raised against this peptide. Gi alpha proteins ...
(CIDRAP News) Health officials in California recently reported another infant death from pertussis, as more states report rising numbers of pertussis cases.The San Diego County Health and Human Services agency announced on Jul 29 that a 1-month-old baby boy died of pertussis on Jul 27 at Rady Childrens Hospital-San Diego. The boys death is prompting new calls from health officials for parents to have themselves and their children vaccinated.
The lipoglycoproteins of the WNT family act on seven transmembrane-spanning Class Frizzled receptors. Here, we show that WNT-5A evokes a proliferative response in a mouse microglia-like cell line (N13), which is sensitive to pertussis toxin, thus implicating the involvement of heterotrimeric G proteins of the G(i/o) family. We continue to show that WNT-5A stimulation of N13 membranes and permeabilized cells evokes the exchange of GDP for GTP of pertussis toxin-sensitive G proteins employing [gamma-(35)S]GTP assay and activity state-specific antibodies to GTP-bound G(i) proteins. Our functional analysis of the PTX-sensitivity of WNT-induced G protein activation and PCR analysis of G protein and FZD expression patterns suggest that WNT-5A stimulation leads to the activation of G(i2/3) proteins in N13 cells possibly mediated by FZD(5), the predominant FZD expressed ...
In the 1990s, the US replaced whole cell pertussis vaccines with acellular pertussis vaccines over safety concerns. A research letter to Journal of the American Medical Association reports that the switch might be responsible for a recent rising number of pertussis cases (whooping cough) in children. Compared with whole cell...
GTP-binding regulatory proteins (G proteins) regulate various biological functions, but their participation in controlling coronary microvascular tone has not been established yet. The goal of the present study was to elucidate the role of pertussis toxin (PTX)-sensitive G protein in regulating coronary microvascular tone during autoregulation and ischemia. In 42 open-chest dogs, coronary arterial microvessels on the surface of the left ventricle were directly observed by epi-illuminated fluorescence microangiography using a floating objective system. PTX (300 ng/mL) was superfused onto the surface of the left ventricle for 2 hours to block Gi and G(o) protein in epimyocardial coronary microvessels in vivo. PTX superfusion caused no change in the resting diameters of microvessels and significantly blocked the vasoconstriction induced by BHT 920 (a selective alpha 2-agonist). After pretreatment with PTX or its vehicle, the left anterior descending coronary artery (LAD) was occluded by a ...
Looking for Bordetella avium? Find out information about Bordetella avium. A nonsporulating, gram-negative coccobacillus that causes respiratory infections in birds Explanation of Bordetella avium
Previous studies on immortalized B lymphoblasts from patients with EH and enhanced Na+-H+ exchanger activity have revealed an enhanced activation of PTX-sensitive G proteins.7 This conclusion was mainly based on two findings. First, HT lymphoblasts displayed enhanced [Ca2+]i signals upon stimulation with platelet-activating factor and somatostatin. Pretreatment with PTX strongly reduced these agonist-evoked Ca2+ signals, and the residual Ca2+ responses were no longer different between NT and HT cell lines. Second, both receptor-mediated stimulation and direct (by mastoparan-7) stimulation of GTPγS binding to PTX-sensitive G proteins were significantly increased in HT lymphoblasts.7 Unfortunately, B lymphoblasts apparently do not express functional receptors that are selectively coupled to PTX-insensitive G proteins, eg, Gq or Gs. Therefore, our proposal of a selective enhancement of signal transduction via PTX-sensitive G proteins in HT cell lines was based on circumstantial evidence but could ...
TY - JOUR. T1 - The effect of pertussis toxin on the growth of vascular smooth muscle cells stimulated by serum or platelet-derived growth factor. AU - Zhang, L. M.. AU - Newman, W. H.. AU - Castresana, Manuel R. AU - Hildebrandt, J. D.. PY - 1994/1/1. Y1 - 1994/1/1. N2 - The involvement of a G(i)- or G(o)-related G-protein as a regulator of the growth of guinea pig thoracic aorta smooth muscle (TASM) cells was studied by investigating the effects of pertussis toxin (PTX) on the growth of these cells. PTX treatment decreased the growth rate of TASM cells by 70-100%. This effect was apparent within 24 h after exposure in the toxin and persisted for at least 10 days after starting the treatment. The effect of the toxin appeared to be the result of the inactivation of a G-protein because 1) TASM cell membranes contained a 40-kilodalton substrate for the toxin in in vitro assays that was absent in membranes prepared from cells pretreated with toxin; and 2) the effect required ...
SPRINGFIELD, Ill. - As we enter flu season, and with reports of increased number of pertussis cases in some Illinois counties, Illinois Department of Public Health Director Dr. Damon T. Arnold is reminding people of the importance of vaccinations and preventive measures that should be used to avoid getting sick.. "Some northern Illinois counties are reporting an increased number of pertussis, or whooping cough, cases this year compared to 2007. This is a good reminder why vaccinations are so important," said Dr. Arnold. "Its also important to do simple things like cover your mouth with a tissue if you cough or sneeze. If you dont have a tissue, try to cough or sneeze into your sleeve. Thoroughly washing your hands with soap and warm water will also prevent the spread of disease. Doing all these things will help keep you and your loved ones healthy.". Lake County and Chicago are reporting an increased number of pertussis cases this year while other counties, ...
Bordetella are small Gram-negative coccobacilli, of which Bordetella pertussis is the most important human pathogen. It is the cause of whooping cough, which is one of the 10 leading causes of childhood death. Transmission of this highly infectious organism is primarily by aerosolized droplets.Clinical features-presentation varies with age, immunization and previous infection: (1) infants-apnoea, cyanosis, and paroxysmal cough; (2) nonimmunized children-cough, increasing in severity with distressing, repeated, forceful expirations followed by a gasping inhalation (the whoop); (3) children immunized in infancy-whooping, vomiting, sputum production; (4) adults-cough, post-tussive vomiting. Atypical mild illness is common. Complications include pneumonia, pulmonary hypertension, seizures and encephalopathy. Most deaths occur in those less than 2 months old....
Pertussis is an infection that causes severe coughing. The bacteria that causes the infection is called Bortella pertussis. Pertussis is called "whooping cough" because of the "whoop-like" sound that can be heard when someone who has is breathes in cold air. Pertussis typically starts with cold-like symptoms: a runny nose, mild fever, and a minor cough. After 1 to 2 weeks, the cough begins to get worse and lasts for many weeks. Sometimes the cough is so bad that one can throw up. A person catches pertussis if they come in close contact with another person who has it. A person who is infected with pertussis is most contagious during the first 2 weeks after the cough begins. Because the symptoms of pertussis in its early stage mimic a common cold, it is often not diagnosed or treated until more severe symptoms occur, putting many people at a high risk of infection. When a person who has ...
This study is the first descriptive epidemiologic study of a large case series of children with HHE. From July 31, 1996, when the first acellular pertussis vaccine was licensed for infants in the United States, to the end of our study period (December 31, 1998), acellular pertussis vaccines became the predominant pertussis-containing vaccines in the United States. During the time of our study (1996-1998), pertussis vaccination coverage rates were stable.11Concurrently, numbers of HHE reports to VAERS decreased from 99 in 1996 to 38 in 1998. This decrease could suggest that HHE occurs less frequently after vaccination with DTaP than after whole-cell pertussis, which is similar to what has been observed in clinical trials with respect to more common adverse events, such as injection site reactions, fever, and fussiness.12-16 Our finding of a decrease in HHE during a time of increasing DTaP usage is consistent with a summary by ...
Diphtheria, tetanus, and pertussis are serious diseases caused by bacteria. Diphtheria causes a thick coating in the nose, throat, and airways. It can lead to breathing problems, paralysis, heart failure, or death. Pertussis (whooping cough) causes coughing so severe that it interferes with eating, drinking, or...
Citation. Linz B, Ivanov YV, Preston A, Brinkac L, Parkhill J, Kim M, Harris SR, Goodfield LL, Fry NK, Gorringe AR, Nicholson TL, Register KB, Losada L, Harvill ET. Acquisition and Loss of Virulence-associated Factors During Genome Evolution and Speciation in Three Clades of Bordetella Species.. BMC Genomics. 2016 Sep 30; 17: 767.. External Citation. Abstract. The genus Bordetella consists of nine species that include important respiratory pathogens such as the classical species B. bronchiseptica, B. pertussis and B. parapertussis and six more distantly related and less extensively studied species. Here we analyze sequence diversity and gene content of 128 genome sequences from all nine species with focus on the evolution of virulence-associated factors.. ...
Rats were immunized with crude Ascaris extracts together with Bordetella pertussis organisms and the homocytotropic antibody titers were estimated by homologous PCA. Rats injected with 1 mg of crude extract produced homocytotropic antibodies giving and average PCA titer of 1:80. A second injection of 100 µg of the extract given 6 days later, without B. pertussis vaccine, caused a considerable increase in the PCA titer. The crude extract was fractionated by DEAE-cellulose chromatography and the fractions were tested in P-K type reactions. The homocytotropic antibodies produced in rats immunized with the crude extract demonstrated a tendency to react with the fractions displaying a negative charge at pH 8.. The capacity of rats to produce Hc antibodies to part of the antigenic components present in the crude extract but not against others was demonstrated when rats were immunized separately with isolated fractions.. ...
The purpose of this study is to evaluate the safety and immunogenicity of a new live attenuated vaccine against whooping-cough. It is a phase1, single centre, dose-escalating, placebo-controlled study on a genetically modified B. pertussis strain given as a single intranasal dose to healthy adult male volunteers.. Effective vaccines are needed to protect young infants (from 0 to 6 months, today the most vulnerable age group), preferably after a single administration very early in life. The successful outcome of this project would constitute an important milestone towards nasal vaccination of infants, possibly at birth with a novel, single-dose pertussis vaccine. Our ultimate aim is to protect infants in the most vulnerable age group, before the regular vaccination schedule using already available vaccines is applied. The ultimate aim is thus not to replace current vaccination schedules with available vaccines, but to add a first nasal vaccination to protect very early in ...
In vivo administration of pertussis toxin is often used to study the involvement of guanine nucleotide binding proteins in signal transduction. Especially when it is administered in the brain the effect is often poor. This could be due to the fact that pertussis toxin does not reach the area of interest. To evaluate the extent to which pertussis toxin is distributed in rat brain after intraventricular injection, different techniques were used. Immunohistochemical studies with an antibody against pertussis toxin showed that immunoreactivity was limited to periventricular brain structures less than 0.5 mm from the lumen. The highest immunoreactivity was seen 16-24 h after injection. After 96 h the labeling was very weak. The proportion of guanine nucleotide binding proteins that were ADP-ribosylated by in vivo injection of pertussis toxin into the ventricles as assessed by in vitro [32P]-back-ADP-ribosylation was very low 48 h ...
We present a previously healthy 6-month-old boy who was admitted to our hospital with lethargy, hypotonia and focal clonic seizures 6 days following diptheria, tetanus toxoid and whole-cell pertussis
Tetanus, diphtheria, and pertussis are serious diseases caused by bacteria. Tetanus (lockjaw) causes painful tightening of the muscles, usually all over the body. It can lead to locking of the jaw so the victim cannot open the mouth or swallow. Tetanus leads to death in about 1 out of 10 cases. Diphtheria causes a...
Epidemic curve of a pertussis outbreak, September 2010-April 2011, Japan. A) Suspected cases of pertussis. B) Laboratory-confirmed cases of Bordetella pertuss
Acellular pertussis vaccine is safe for routine immunization in early childhood, claim researchers from the Centers for Disease Control and Prevention (CDC) in Pediatrics. An association has long been noted between the previously used diphtheria-tetanus toxoids-pertussis (DTP) vaccine and seizures, but limited population studies have evaluated the risk with the diphtheria-tetanus-acellular pertussis (DTaP) vaccine that has replaced DTP. The authors did a retrospective study of data from seven managed care organizations that are part of the Vaccine Safety Datalink project and compared the incidence of seizures in "exposure" periods (0 to 3 days after DTaP vaccination) and control periods in children aged 6 weeks to 23 months. A total of 7,191 seizure events occurred among the 433,654 subjects, but the incidence was not higher during the exposure periods ...
Pertussis infection has been suspected to be a potential causal factor in the development of atopic disease because of the effect of pertussis immunization on specific IgE antibodies. Although several studies found a positive association between pertussis infection and atopic disorders, this relationship has not yet been studied in a population stratified by vaccination status. To assess the association between pertussis infection and atopic disorders in pertussis-unvaccinated children and in pertussis-vaccinated children. Using data from a previously conducted study on the relationship between the diphtheria-tetanus-pertussis-(inactivated) poliomyelitis vaccination in the first year of life and atopic disorders, the study population of 1872 8-12 yr old was divided into children pertussis-unvaccinated and children pertussis-vaccinated in the first year of ...
To the Editor: Due to their lower rate of adverse events, acellular pertussis vaccines (diphtheria-tetanus-acellular pertussis; DTaP) replaced whole cell vaccin
... ! Azitrobac is a macrolide antibiotic of azalides group. Azitrobac inhibits RNA-dependent protein synthesis of sensitive microorganisms. It active against gram-positive bacteria: Staphylococcus aureus, Streptococcus spp. (including Streptococcus pneumoniae, Streptococcus pyogenes group A); gram-negative bacteria: Haemophilus influenzae, Haemophilus parainfluenzae, Haemophilus ducreyi, Moraxella catarrhalis, Escherichia coli, Bordetella pertussis, Bordetella parapertussis, Borrelia burgdorferi, Neisseria gonorrhoeae, Campylobacter spp., Legionella pneumophila; anaerobic bacteria: Bacteroides fragilis.
Both calcitonin and prostaglandin E2 (PGE2) stimulate adenylate cyclase activity in the human breast cancer cell line (T 47D). The maximum cyclic AMP response to calcitonin exceeds that of PGE2. When maximal concentrations of the two hormones were added simultaneously to the cells, the amount of cyclic AMP generated was less than that seen with calcitonin alone. When cells were treated with the protein toxin of Bordetella pertussis (islet-activating protein; IAP) which inactivates the inhibitory regulatory component (Ni) of adenylate cyclase, there was no change in basal or calcitonin-responsive adenylate cyclase in intact cells. However, the PGE2 response was augmented at all dose levels, and this effect was dependent on the concentration of IAP. Moreover, in cells pretreated with IAP, simultaneous addition of PGE2 and calcitonin resulted in additivity rather than in inhibition of cyclic AMP production. The additivity of the response to calcitonin and PGE2 ...
Dr. Diamond responded: Ingredients. The acellular pertussis vaccines is now recommended to be given at least once to all adults . There is no recommendation for more than 1 adult booster, but i would not be surprised to see it given for every booster (7-10 yrs) in the future.The other differences are related to the specific type of antigens and quatity in each vaccine.Antigens are the material that triggers your immunity.
Free, official coding info for 2018 ICD-10-CM A37.11 - includes detailed rules, notes, synonyms, ICD-9-CM conversion, index and annotation crosswalks, DRG grouping and more.
Methane is metabolized principally by methanotrophs and methanogens in the global carbon cycle. Methanotrophs consume methane as the only source of carbon, while methanogens produce methane as a metabolic byproduct. Methylotrophs, which are microorganisms that can obtain energy for growth by oxidizing one-carbon compounds, such as methanol and methane, are situated between methanotrophs and methanogens. Methanogens can obtain energy for growth by converting a limited number of substrates to methane under anaerobic conditions. Three types of methanogenic pathways are known: CO2 to methane [MD:M00567], methanol to methane [MD:M00356], and acetate to methane [MD:M00357]. Methanogens use 2-mercaptoethanesulfonate (CoM; coenzyme M) as the terminal methyl carrier in methanogenesis and have four enzymes for CoM biosynthesis [MD:M00358]. Coenzyme B-Coenzyme M heterodisulfide reductase (Hdr), requiring for the final reaction steps of methanogenic pathway, is divided into two types: cytoplasmic HdrABC in ...
Bordetella bronchiseptica ATCC ® 4617™ Designation: NRRL B-140 TypeStrain=False Application: Assay of colistimethate sodium Assay of colistin colimycin Assay of polymyxin B Susceptibility disc testing colistin colimycin Susceptibility disc testing polymyxin B Pharmaceutical and Personal Care
Tetanus-diphtheria-acellular pertussis (Tdap) vaccine is recommended for all pregnant women in the U.S. as the key medical intervention to protect newborn infants from pertussis (whooping cough). However, the safety of giving the Tdap vaccine to pregnant women has not been fully determined. According to a new study the Tdap vaccine is safe for both mothers and infants ...
Respiratory infections are common causes of morbidity and mortality. Chlamydia pneumoniae, Mycoplasma pneumoniae and Bordetella pertussis cause respiratory infection, often with similar symptoms. Molecular diagnostic methods are preferred since these bacteria are difficult to culture. The aim of this thesis was to evaluate and improve the diagnostics and knowledge of the epidemiology of these bacteria.. A real-time polymerase chain reaction (PCR) method targeting the IS481 element present in the genome of B. pertussis was compared to culture and serology results, and a duplex real-time PCR method was constructed for detecting C. pneumoniae and M. pneumoniae, which was compared to two endpoint PCR methods. Both real-time PCR methods showed high sensitivity and specificity.. Typing of 624 M. pneumoniae samples, collected from 1996 to 2017 from four counties, was performed by P1 typing and multiple-locus variable number tandem repeat analysis ...
Chronic stimulation of beta-adrenoceptors leads to increased mRNA and protein levels of pertussis toxin (PTX)-sensitive guanine nucleotide-binding proteins (G proteins) in the heart. In the present study the time course is reported of the effect of isoprenaline infusions on myocardial mRNA levels of Gi alpha-2, Gi alpha-3, G(o) alpha, Gs alpha, and G beta and myocardial levels of PTX-sensitive G proteins. Rats were treated by subcutaneous infusions, with osmotic minipumps, of 0.9% NaCl, isoprenaline (2.4 mg/kg/day), propranolol (9.9 mg/kg/day), or a combination thereof for 1, 2, 3, 4, or 8 days, and two groups were treated with NaCl or isoprenaline for 13 or 26 days. Additional groups of rats were treated with 0.24 or 0.07 mg/kg/day for 4 days to determine the dose dependency of the effects of isoprenaline. mRNA concentrations were determined by standardized slot blotting with 32P-labeled cDNA or cRNA probes. In isoprenaline-treated rats, mRNA levels of all members of the Gi alpha/G(o) alpha ...
TY - JOUR. T1 - The effect of pertussis vaccine on reaginic antibody formation and histamine response in children. AU - Gifford, C. G.. AU - Villacorte, G.. AU - Bewtra, A. K.. AU - Townley, R. G.. PY - 1976/1/1. Y1 - 1976/1/1. UR - http://www.scopus.com/inward/record.url?scp=0017287337&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0017287337&partnerID=8YFLogxK. M3 - Article. AN - SCOPUS:0017287337. VL - 57. SP - No.30. JO - Journal of Allergy and Clinical Immunology. JF - Journal of Allergy and Clinical Immunology. SN - 0091-6749. IS - 3. ER - ...
What is the Tetanus, Diphtheria, Acellular Pertussis (Tdap) Vaccine? The Tdap vaccine is designed to protect adolescents and adults from te...
With the pertussis outbreak in California nearing a 60-year high in the number of cases reported, the CDCs Advisory Committee on Immunization Practices, or ACIP, has voted to recommend the off-label use of tetanus, diphtheria and acellular pertussis, or Tdap, vaccine in two specific patient groups.
Achoo!. Feel like a sneeze or cough coming on? Cover it in a cloth or tissue paper, or even your sleeves, and wash your hands, admonishes the Centers for Disease Control and Prevention (CDC) - and for good reasons, too! Microbial pathogenic agents of a variety of respiratory illnesses, both viral [ranging from the common cold (rhinovirus); influenza (orthomyxovirus); parainfluenza viruses, respiratory syncytial virus (RSV), and human metapneumovirus (all paramyxoviruses); severe acute respiratory syndrome (SARS-Coronavirus)] as well as bacterial [such as those responsible for pneumonia (Streptococcus pneumoniae), whooping cough (Bordetella pertussis), and tuberculosis (Mycobacterium tuberculosis)] are often transmitted by cough, sneeze, and/or unclean hands/palms carrying these germs on their surfaces.. Continue reading. ...
African trypanosomes of the Trypanosoma brucei species are extra-cellular parasites that cause human African trypanosomiasis (HAT) as well as infections in game animals and livestock. Trypanosomes are known to evade the immune response of their mammalian host by continuous antigenic variation of their surface coat. Here, we aim to demonstrate that in addition, trypanosomes (i) cause the loss of various B cell populations, (ii) disable the hosts capacity to raise a long-lasting specific protective anti-parasite antibody response, and (iii) abrogate vaccine-induced protective response to a non-related human pathogen such as Bordetella pertussis. Using a mouse model for T. brucei, various B cell populations were analyzed by FACS at different time points of infection. The results show that during early onset of a T. brucei infection, spleen remodeling results in the rapid loss of the IgM(+) marginal zone (IgM(+)MZ) B cell population characterized as ...
This comes as the Illinois Department of Public Health on Tuesday alerted residents statewide to a series of pertussis outbreaks. "We note the recommendations of health officials that the best thing people can do to keep themselves and their families healthy during a possible outbreak is to get vaccinated," said Denise Scarpelli, Illinois market pharmacy director for Walgreens. "In addition to children, who are the most vulnerable, those who care for or are in contact with children should also be immunized. We hope that through greater access to immunizations, we can keep our communities healthy and help limit the spread of the virus.". McHenry County has reported an outbreak of more than 200 whooping cough cases, a county record, which it said is affecting more than 30 area schools. Last week, officials in Lake County issued an alert urging residents to be aware of signs and symptoms that can be associated with whooping cough (coughing, vomiting, spasms), as a growing number of cases now ...
Achoo!. Feel like a sneeze or cough coming on? Cover it in a cloth or tissue paper, or even your sleeves, and wash your hands, admonishes the Centers for Disease Control and Prevention (CDC) - and for good reasons, too! Microbial pathogenic agents of a variety of respiratory illnesses, both viral [ranging from the common cold (rhinovirus); influenza (orthomyxovirus); parainfluenza viruses, respiratory syncytial virus (RSV), and human metapneumovirus (all paramyxoviruses); severe acute respiratory syndrome (SARS-Coronavirus)] as well as bacterial [such as those responsible for pneumonia (Streptococcus pneumoniae), whooping cough (Bordetella pertussis), and tuberculosis (Mycobacterium tuberculosis)] are often transmitted by cough, sneeze, and/or unclean hands/palms carrying these germs on their surfaces.. Continue reading. ...
A stimulating paper from Mohrs and colleagues that shows that IL-4 and IFN-g signaling during Heligmosomoides polygyrus or Toxoplasma gondii respectively, is: i) widespread throughout the LN, ii) independent of direct cell contact and, iii) is not a limiting factor in B cell maturation or helper T cell differentiation. These results are challenging in view of our own data that show that during LN responses to alum-precipitated protein antigens IL-4 is dispensable for the early induction, but not for the maintenance, of Th2-features including B cell maturation or helper T cell differentiation more. In addition, previous work from our laboratory has shown that Th1 and Th2 characteristics start to develop during T cell priming to alum-precipitated protein mixed with killed Bordetella pertussis. This suggests that cytokines in these circumstances do not act globally in the LN, and that Th2 response to hapten-protein can proceed in a node where there is ...
Pertussis, a highly contagious but vaccine preventable disease also known as whooping cough, is on the rise across North America, including here in Simcoe Muskoka. But why is pertussis resurfacing, you might ask? There is a natural cyclical increase of pertussis every 4 to 6 years, but decreased immunity of previously vaccinated adults is another explanation for the increase in cases.. Alberta, British Columbia, New Brunswick and parts of Ontario are experiencing significant outbreaks of pertussis. Even more concerning is that the United States is on the verge of the worst outbreak of pertussis since 1959, with more than 22,000 cases and 13 deaths reported since January. A bacterial infection of the respiratory tract, pertussis is largely preventable through vaccination. The pertussis vaccine is part of the routine childhood immunization schedule. In Ontario, this vaccination is publically ...
In March 1991 the Supreme Board of Health issued new recommendations for immunization of children which are basically similar to those issued in 1989, but were partially reformulated. Again, BCG vaccination is not generally recommended and should be given only to individuals at high risk of contracting the disease. It is therefore not listed any more in the general recommendations (A) but only mentioned under special vaccinations (B). Special indications for BCG vaccination were clearly reformulated. Vaccinations against diphtheria-tetanus or pertussis-diphtheria-tetanus are recommended as usual, an oral pertussis vaccine is presently not available and an acellular pertussis vaccine is under study. Booster vaccinations at school entry will be performed with a low dose of diphtheria-toxoid to avoid local side reactions.
4 or more doses of any diphtheria and tetanus toxoids and pertussis vaccines including diphtheria and tetanus toxoids, and any acellular pertussis vaccine (DTP/DTaP/DT ...
with a reduced reaction rate. Current research is directed toward development of a vaccine consisting principally of one or more of the bacterial components thought to provide protection. Prominent candidate antigens include filamentous hemagglutinin and lymphocytosis promoting factor (pertussis toxin). However, several years will be necessary to complete development and to document the potency, safety, and efficacy of a new vaccine. VACCINE USAGE The standard single-dose volume of DTP, DT, Td, single-antigen adsorbed preparations of pertussis vaccine, tetanus toxoid, and diphtheria toxoid, and the nonadsorbed tetanus toxoid is 0.5 ml. Adsorbed preparations should be administered intramuscularly (IM). Vaccine administration by jet injection may be associated with more frequent local reactions. (See also: ACIP: General recommendations on immunization. MMWR 1983;32:1-8,13-7.) Primary Immunization Children 6 weeks through 6 years old (up to the seventh birthday) (Table 1). One ...
Citation: Brockmeier, S., Register, K.B. 2007. Expression of the dermonecrotic toxin by Bordetella bronchiseptica is not necessary for predisposing to infection with toxigenic Pasteurella multocida. Veterinary Microbiology. 125(3-4):284-289. Interpretive Summary: Infection with Bordetella bronchiseptica predisposes pigs to infection with Pasteurella multocida, and coinfection with these agents is often found in cases of progressive atrophic rhinitis, a disease which causes deformed growth of the pigs snout. There are several potential mechanisms by which B. bronchiseptica could predispose to infection with P. multocida. B. bronchiseptica produces a toxin called the dermonecrotic toxin, or DNT, which induces damage to swine nasal tissue and causes pneumonia and could play a role in increased colonization by P. multocida. This experiment was designed to determine whether a strain of B. bronchiseptica which does not produce DNT is still capable ...
Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine Adsorbed, • Adacel is a vaccine indicated for active booster immunization against tetanus, diphtheria and pertussis. Adacel is approved for use as a single dose in persons 10 through 64 years of age
In fact, the whole question of vaccine detoxification has never been systematically investigated.. Listed in order of increasing severity, observed adverse reactions include irritability, persistent, unusually high pitch crying, somnolence, seizures, a shock-like "hypotensive, hyporesponsive" state, and encephalopathy. Since the neurologic picture is not specific for pertussis vaccination, its temporal relationship to the vaccination is that critical variable for determining causation.. Menckes and Kinsbourne went on to say that although the majority of seizures following pertussis vaccination were associated with fever, it was the consensus of the neurologists attending the workshop, that they did not represent febrile convulsions but that they were in fact non-benign convulsions.. The incidence of post-vaccine encephalopathy was difficult to ascertain. Quoting a British study by Miller published in the British Medical Journal in 1981, Menkes and Kinsbourne stated: "…The ...
DTPP Vaccine Suspension for injectionWhat is this medicine?DIPHTHERIA TOXOID, TETANUS TOXOID, ACELLULAR PERTUSSIS VACCINE, DTaP; INACTIVATED POLIOVIRUS VAC
VAERS ID 209245-1: "This subject is a three month old female, who suffered a fatal head injury while enrolled in a comparative post marketing safety study of Daptacel (diptheria and tetanus toxoids and acellular pertussis vaccine absorbed) administered with other recommended vaccines according to the US standard of care. The subject received one dose of study vaccine: the last dose prior to the event was given on 01/14/2003. The subject ""expired instantly due to blunt head injuries in motor vehicle accident described as ""auto vs. fixed object, ejected,"" 18 days post immunization and expired the same day. No other information was reported. Death Certificate has been received. Autopsy has been performed but report not yet received. The event of fatal head injury was reported by the investigator as unrelated to the study product. The autopsy report states accident automobile, death. Follow up on 09/30/2003: ""Autopsy Report received by medical affairs on 09/16/2003. This three-month-old ...
VAERS ID 209245-1: "This subject is a three month old female, who suffered a fatal head injury while enrolled in a comparative post marketing safety study of Daptacel (diptheria and tetanus toxoids and acellular pertussis vaccine absorbed) administered with other recommended vaccines according to the US standard of care. The subject received one dose of study vaccine: the last dose prior to the event was given on 01/14/2003. The subject ""expired instantly due to blunt head injuries in motor vehicle accident described as ""auto vs. fixed object, ejected,"" 18 days post immunization and expired the same day. No other information was reported. Death Certificate has been received. Autopsy has been performed but report not yet received. The event of fatal head injury was reported by the investigator as unrelated to the study product. The autopsy report states accident automobile, death. Follow up on 09/30/2003: ""Autopsy Report received by medical affairs on 09/16/2003. This three-month-old ...
Monkeys and mice surviving cerebral infection with yellow fever virus of relatively avirulent strains have been found to resist maximal intracerebral doses of yellow fever virus of a highly neurotropic strain. Such animals, however, do not resist more than very small doses of intracerebrally inoculated virus of Eastern equine encephalomyelitis. Animals immunized by extraneural routes, on the other hand, are not uniformly resistant to neural infection with neurotropic yellow fever virus. Monkeys which have undergone systemic infection with virus of the avirulent 17D strain or of several jungle strains resist only small intracerebral doses of neurotropic virus; while mice, even when possessed of very high serum-antibody levels as the result of intraperitoneal hyperimmunization, manifest only an irregular resistance to intracerebral challenge inocula. The difference in the resistance of neurally and extraneurally immunized animals is not related to similar differences in the levels of protective ...
These vaccines can protect your baby from 7 childhood diseases: : 1. Diphtheria : Signs and symptoms include a thick coating in the back of the throat that can make it hard to breathe. : Diphtheria can lead to breathing problems, paralysis and heart ...
By Sandra Yin May 19, 2011 (Baltimore, Maryland) - The protective power of the diphtheria, tetanus, acellular pertussis vaccination (DTaP) wanes with time, according to a study presented here at the National Foundation for Infectious Diseases 14th Annual Conference on Vaccine Research. "The most surprising finding is that the vaccine wanes as much as it ...
Canine influenza (also known as CIV) is an upper respiratory virus spread from other dogs only. Two strains of this virus are known H3N2 and H3N8, both strains have been found in the Northwestern Ohio area. This virus is airborne and highly contagious and is most commonly contracted in places such as dog parks, boarding, and grooming facilities. Like Bordetella, canine influenza can cause a harsh cough but has the potential for more severe effects and a longer lasting illness compared to Bordetella. Some dogs can develop pneumonia secondary to canine influenza. This vaccine is recommended for all dogs but is required for all our boarding and grooming pets ...
There are two treatment options depending on the severity of the disease. In the most common mild (uncomplicated) form of the disease, antibiotics may or may not be used. Treating the mild case does not shorten the length in which the animal will be a potential spreader of the disease. In addition, bronchodilators like aminophylline or cough suppressants may also be used in treatment of mild cases. In more severe (complicated) cases where the animal is not eating, running a fever, or showing signs of pneumonia, antibiotics are often used. The most common ones are doxycycline or trimethoprim-sulfa. However, many other choices are also available. Steroids or cough suppressants are not usually recommended because of the risk of immunosuppression with steroids and the need to continue to clear extra fluid or mucous in pneumonia patients. Bronchodilators and even aerosol therapy can be used. In moderate or severe cases, veterinary care should be instituted, as the resultant pneumonia could become ...
Bordetella vaccine is given to aid in the prevention of "Kennel Cough", the most prevalent upper respiratory problem in dogs in the United States. The condition is also known as tracheobronchitis, canine infectious tracheobronchitis, Bordetellosis, or Bordetella. It is highly contagious in dogs. The disease is found worldwide and will infect a very high percentage of dogs in their lifetime ...
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Eight collie-cross pups, eight weeks old, were inoculated intramuscularly with an aluminum hydroxide adjuvanted preparation of killed Bordetella bronchiseptica; the inoculation was repeated after two weeks. Two weeks after the second inoculation, the vaccinated dogs and a control group of four unvaccinated animals were placed in contact with a group of five pups of similar age which had been experimentally infected with a pathogenic strain of B bronchiseptica by an aerosol method. All four unvaccinated control dogs as well as all five experimentally infected dogs developed a respiratory disease characterised by persistent coughing. Six of the vaccinated dogs remained free from clinical respiratory disease while disease was less severe and of shorter duration in the remaining two than in controls. Only slight changes were found in the lungs of vaccinated animals at necropsy while in the controls there was a severe tracheobronchitis. There was a marked reduction in the numbers ...

Bordetella bronchiseptica, SEM - Stock Image C032/2756 - Science Photo LibraryBordetella bronchiseptica, SEM - Stock Image C032/2756 - Science Photo Library

... which is one of the characteristic virulence factors of B. pertussis. It is related to Bordetella pertussis, the obligate human ... of Bordetella bronchiseptica, Gram-negative, aerobic, motile, coccobacillus prokaryote (bacterium). Bordetella bronchiseptica ... B. bronchiseptica does not express pertussis toxin, which is one of the characteristic virulence factors of B. pertussis. ... which is one of the characteristic virulence factors of B. pertussis. It is related to Bordetella pertussis, the obligate human ...
more infohttp://www.sciencephoto.com/media/799575/view

Bordetella - WikipediaBordetella - Wikipedia

"Phosphorylated BvgA is sufficient for transcriptional activation of virulence-regulated genes in Bordetella pertussis". EMBO J ... Other bacteria recycle this molecule back into the cytoplasm, but in Bordetella and Neisseria gonorrhoeae, it is released into ... In these conditions, some, but not all of the virulence factors associated with the Bvg+ phase are expressed, suggesting this ... and Clinical Manifestations of Respiratory Infections Due to Bordetella pertussis and Other Bordetella Subspecies". Clin ...
more infohttps://en.wikipedia.org/wiki/Bordetella

0288 Complete genome sequence of a clinical Bordetella pertussis isolate from Brazil0288 Complete genome sequence of a clinical Bordetella pertussis isolate from Brazil

... including the three human pathogens Bordetella pertussis, Bordetella parapertussis an... ... The genus Bordetella consists of Gram-negative β-proteobacteria, ... Sequences required for expression of Bordetella pertussis virulence factors share homology with prokaryotic signal transduction ... The B. pertussis Bz181 strain is deposited in the Collection of Bacteria of the Environment and Health at the Oswaldo Cruz ...
more infohttp://memorias.ioc.fiocruz.br/issues/current-issue/item/2271-0288_complete-genome-sequence-of-a-clinical-bordetella-pertussis-isolate-from-brazil

Bordetella adenylate cyclase toxin: the role of cell interaction in toxin functio - Joshua EbyBordetella adenylate cyclase toxin: the role of cell interaction in toxin functio - Joshua Eby

... is necessary for disease caused by Bordetella pertussis, which has reemerged in the United States over the last two decad... ... by AC toxin and show that these mechanisms affect the function of the toxin and determine its role as a virulence factor. ... and important because the bacterium first encounters these cells upon infection. These studies will shed light upon the ... 2012) Role of CD11b/CD18 in the process of intoxication by the adenylate cyclase toxin of Bordetella pertussis. Infect Immun 80 ...
more infohttp://grantome.com/grant/NIH/K08-AI081900-05

Changes in the genomic content of circulating Bordetella pertussis strains isolated from the Netherlands, Sweden, Japan and...Changes in the genomic content of circulating Bordetella pertussis strains isolated from the Netherlands, Sweden, Japan and...

... pertussis strains, and represent 84.8% of all CDSs found in the 171 B. pertussis strains. A total of 64 regions of difference ... pertussis isolates from different countries. The CGH microarray analysis estimated the core genome of B. pertussis, to consist ... pertussis. Our results show that B. pertussis is a dynamic organism that continues to evolve. ... In an attempt to gain insight into the genomic make-up of B. pertussis over the last 60 years, we used an oligonucleotide DNA ...
more infohttps://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-11-64

Rapid Identification of Bordetella pertussis Pertactin Gene Variants Using LightCycler Real-Time Polymerase Chain Reaction...Rapid Identification of Bordetella pertussis Pertactin Gene Variants Using LightCycler Real-Time Polymerase Chain Reaction...

... have been characterized in Bordetella pertussis strains isolated in Europe and the United States. It has been suggested that ... The method is simple and reliable and provides an alternative for sequencing in pertussis research. ... the divergence of the pertactin types of clinical isolates from those of the B. pertussis vaccine strains is a result of ... pertussis bacteria to vaccine-induced immunity. Pertactin, a 69-kDa outer membrane protein, is an important virulence factor of ...
more infohttps://wwwnc.cdc.gov/eid/article/7/6/01-0606_article

Bordetella pertussis - WikipediaBordetella pertussis - Wikipedia

Unlike B. bronchiseptica, B. pertussis is not motile. Its virulence factors include pertussis toxin, filamentous hæmagglutinin ... B. pertussis infects its host by colonizing lung epithelial cells. The bacterium contains a surface protein, filamentous ... 16: Pertussis Parkhill J, et al. (2003). "Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella ... Bordetella pertussis is a Gram-negative, aerobic, pathogenic, encapsulated coccobacillus of the genus Bordetella, and the ...
more infohttps://en.wikipedia.org/wiki/Bordetella_pertussis

Toxins  | Free Full-Text | Serine Protease Autotransporters of Enterobacteriaceae (SPATEs): Biogenesis and Function | HTMLToxins | Free Full-Text | Serine Protease Autotransporters of Enterobacteriaceae (SPATEs): Biogenesis and Function | HTML

Emsley, P.; Charles, I.G.; Fairweather, N.F.; Isaacs, N.W. Structure of Bordetella pertussis virulence factor P.69 pertactin. ... In gram-negative bacteria, heme-acquisition occurs by two distinct mechanisms. In one mechanism, bacteria directly bind heme or ... Hbp: Hemoglobin protease from E. coli (PDB entry 1WXR) [5], Prn: Bordetella pertussis Pertactin (PDB entry 1DAB) [4], VacA: ... Hbp: Hemoglobin protease from E. coli (PDB entry 1WXR) [5], Prn: Bordetella pertussis Pertactin (PDB entry 1DAB) [4], VacA: ...
more infohttp://www.mdpi.com/2072-6651/2/6/1179/htm

Filamentous haemagglutinin adhesin - WikipediaFilamentous haemagglutinin adhesin - Wikipedia

One notable bacterium that produces filamentous hæmagglutinin adhesin is Bordetella pertussis, which uses this protein as a ... virulence factor.. ... filamentous protein that serves as a dominant attachment factor ...
more infohttps://en.wikipedia.org/wiki/Filamentous_haemagglutinin_adhesin

Complete genome sequence of Vibrio fischeri: A symbiotic bacterium with pathogenic congeners | PNASComplete genome sequence of Vibrio fischeri: A symbiotic bacterium with pathogenic congeners | PNAS

... produced by Bordetella pertussis and Neisseria meningitides, indicating that bacterial virulence factors not only are context ... in other bacteria they play a role in obtaining genes encoding virulence factors or resistance to environmental stresses (15, ... The TCP Genes in V. fischeri. In V. cholerae, the TCP is an important virulence factor (28). The genes encoding its synthesis ... Such studies within the genus Vibrio may help reveal not only the evolutionary origins of host-targeted virulence factors, but ...
more infohttps://www.pnas.org/content/102/8/3004?ijkey=9d02d3e4633c34dbb47a847928342f4533db2341&keytype2=tf_ipsecsha

The Comprehensive Sourcebook of Bacterial Protein Toxins - 4th EditionThe Comprehensive Sourcebook of Bacterial Protein Toxins - 4th Edition

... produced by Bordetella pertussis, the causative agent of whooping cough. CyaA is an essential virulence factor from B. ... pertussis, and belongs to the large family of RTX (Repeat in ToXins) cytolysins produced by diverse Gram-negative bacteria. By ... is the Head of the Anaerobic Bacteria and Toxins Unit and the Director of the National Reference Center for Anaerobic Bacteria ... Bacterial toxins are involved in the pathogenesis of many bacteria, some of which are responsible for severe diseases in human ...
more infohttps://www.elsevier.com/books/the-comprehensive-sourcebook-of-bacterial-protein-toxins/alouf/978-0-12-800188-2

Structural Organization of Virulence-Associated Plasmids of Yersinia pestis | Journal of BacteriologyStructural Organization of Virulence-Associated Plasmids of Yersinia pestis | Journal of Bacteriology

It also has been found in an array of bacterial virulence factors, such as the Bordetella pertussis adherence factor ... which mediates the uptake of the bacteria into macrophages without triggering an oxidative burst, thus protecting the bacteria ... 1993) Attachment factors of Bordetella pertussis: mimicry of eukaryotic cell recognition molecules. Trends Microbiol. 1:192-196 ... 1994) Bordetella pertussis filamentous hemagglutinin interacts with a leukocyte signal transduction complex and stimulates ...
more infohttps://jb.asm.org/content/180/19/5192?ijkey=9c1d02ba16e8ada3f27fdfd6f74bdad2b38c3d27&keytype2=tf_ipsecsha

A cocktail of humanized anti-pertussis toxin antibodies limits disease in murine and baboon models of whooping cough | Science...A cocktail of humanized anti-pertussis toxin antibodies limits disease in murine and baboon models of whooping cough | Science...

Pertussis toxin and extracytoplasmic adenylate cyclase as virulence factors of Bordetella pertussis. J. Infect. Dis. 150, 219- ... B. pertussis strain D420 was isolated from a critically ill infant in Texas in 2002 (22). Bacteria were maintained on Regan- ... Pertussis toxin plays an early role in respiratory tract colonization by Bordetella pertussis. Infect. Immun. 71, 6358-6366 ( ... The antibodies both bind to the key virulence factor pertussis toxin at distinct sites, mitigating its damaging effects. In ...
more infohttps://stm.sciencemag.org/content/7/316/316ra195.full

PPT - NONSPECIFIC  DEFENSES  OF THE HOST PowerPoint Presentation - ID:4234348PPT - NONSPECIFIC DEFENSES OF THE HOST PowerPoint Presentation - ID:4234348

Sometimes these factors are referred to as bacterial invasins. *Still other bacteria such as Bordetella pertussis and ... protecting the bacteria during the early stages of infection or until they develop a full complement of virulence factors ... These systems involve various types of non-toxin virulence factors. * ... Mechanical Factors. The intact skin consists of the dermis, an inner thicker portion composed of connective tissue, and the ...
more infohttp://www.slideserve.com/heinz/nonspecific-defenses-of-the-host

View source for Haemophilus pertussis (Whooping Cough) - microbewikiView source for Haemophilus pertussis (Whooping Cough) - microbewiki

Another quick test consists of using monoclonal antibodies against the bacteriums virulence factors: lipo-oligosaccharide and ... Heamophilus pertussis or Bordetella pertussis. It was first isolated in 1906 by Jules Bordet. B. pertussis is an ... Bordetella pertussis is pyrogenic, mitogenic, and toxic and can activate and induce tumor necrosis factor production in ... Virulence factors=== ====Ahesins==== Filamentous hemagglutinin (FHA) is required for B. pertussiss tracheal colonization. ...
more infohttps://microbewiki.kenyon.edu/index.php?title=Haemophilus_pertussis_

Bordetella bronchiseptica, SEM - Stock Image - C032/2757 - Science Photo LibraryBordetella bronchiseptica, SEM - Stock Image - C032/2757 - Science Photo Library

... of Bordetella bronchiseptica, Gram-negative, aerobic, motile, coccobacillus prokaryote (bacterium). Bordetella bronchiseptica ... which is one of the characteristic virulence factors of B. pertussis. It is related to Bordetella pertussis, the obligate human ... B. bronchiseptica does not express pertussis toxin, which is one of the characteristic virulence factors of B. pertussis. ... bacterium). Bordetella bronchiseptica typically infects the respiratory tracts of smaller mammals (cats, dogs, rabbits). It ...
more infohttps://www.sciencephoto.com/media/799576/view/bordetella-bronchiseptica-sem

Genes, Epigenetics & Chronic Illness: Why Wheat is Dietary Suspect #1Genes, Epigenetics & Chronic Illness: Why Wheat is Dietary Suspect #1

... their expression is influenced by factors such as the presence or absence of key dietary nutrients and anti-nutrient ... the immunodominant sequence in the Bordetella pertussis bacteria (whooping cough). Pertactin is considered a highly immunogenic ... virulence factor, and is used in vaccines to amplify the adaptive immune response.. It is possible the immune system may ... The implications of these findings are rather extraordinary: epigenetic and not genetic factors are primary in determining ...
more infohttp://www.prohealth.com/me-cfs/library/showArticle.cfm?libid=17644

Peggy Cotter, PhD | Department of Microbiology and ImmunologyPeggy Cotter, PhD | Department of Microbiology and Immunology

One of the main virulence factors produced by Bordetella pertussis and Bordetella bronchiseptica is filamentous hemagglutinin ( ... We are especially interested in 1) how and why bacteria differentially regulate the expression of virulence factor-encoding ... In Bordetella, expression of all known protein virulence factor-encoding genes is controlled by a sensory transduction system ... pseudomallei genome function as virulence factors, analogous to Bordetella FHA. Instead, we discovered that these proteins ...
more infohttps://www.med.unc.edu/microimm/directory/peggy-cotter/

DTap-IPV-Hib Vaccine Linked to SeizuresDTap-IPV-Hib Vaccine Linked to Seizures

... five components of the bordetella pertussis bacteria, filamentous haemagglutinin (the component of the bacteria which causes ... a highly immunogenic virulence factor), three types of inactivated polio virus, types 1, 2 and 3, a component of Haemophilus ... is the one we chose to vaccinate our children with due to my sons heart condition and the risk and prevalence of pertussis. We ...
more infohttps://ecochildsplay.com/2012/02/26/dtap-ipv-hib-vaccine-linked-to-seizures/

Significant Gene Order and Expression Differences in Bordetella pertussis Despite Limited Gene Content Variation | Journal of...Significant Gene Order and Expression Differences in Bordetella pertussis Despite Limited Gene Content Variation | Journal of...

Surprisingly, genes for two virulence factors, pertactin (prn) and filamentous hemagglutinin (fhaB), had higher transcript ... pertussis strain surveyed indicates that such genes are not essential for survival of the bacterium but may be important for ... Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica. ... and Bordetella pertussis is an obligate pathogen of humans.. B. pertussis causes whooping cough, a significant source of ...
more infohttps://jb.asm.org/content/188/7/2375?ijkey=6d1817eaa40c82b773285121d61c0ec67c7a2bae&keytype2=tf_ipsecsha

Subtilase cytotoxin (SubAB) - CFGparadigmsSubtilase cytotoxin (SubAB) - CFGparadigms

... pertussis toxin (Ptx); and (iii) Shiga toxin (Stx). In each case, these AB5 toxins are key virulence factors of the bacteria ... pertussis toxin (Ptx) is produced by Bordetella pertussis, and shiga toxin (Stx) is produced by Shiga toxigenic E. coli (STEC) ... Bordetella pertussis (Ptx); Shiga toxigenic E. coli [STEC] and Shigella dysenteriae (Stx). A fourth sub-family, subtilise ...
more infohttp://functionalglycomics.org/CFGparadigms/index.php?title=Subtilase_cytotoxin_

Anthraniloyl-derived nucleotides as potent and selective adenylyl cyclase inhibitors  - University of Regensburg Publication...Anthraniloyl-derived nucleotides as potent and selective adenylyl cyclase inhibitors - University of Regensburg Publication...

The immobile and aerobic bacterium Bordetella pertussis secretes the key virulence factor, the adenylyl cyclase toxin CyaA. ... Das immobile und aerobe Bakterium Bordetella pertussis sondert den wichtigen krankheitsbestimmenden Faktor, das Adenylyl- ...
more infohttps://epub.uni-regensburg.de/13416/

Wheat - why its not good 29% of Americans diet is wheat - Page 2 - Cuisine and Cooking Forum - Forums of Pravda.RuWheat - why it's not good 29% of American's diet is wheat - Page 2 - Cuisine and Cooking Forum - Forums of Pravda.Ru

... the immunodominant sequence in the Bordetella pertussis bacteria (whooping cough). Pertactin is considered a highly immunogenic ... virulence factor, and is used in vaccines to amplify the adaptive immune response. It is possible the immune system may confuse ... However, determining the factors associated with greater or lesser degrees of susceptibility to gliadins intrinsically toxic ... Consequently, any dietary or environmental factor which facilitates synthesis of MMPs is not a good thing for cardiovascular ...
more infohttps://engforum.pravda.ru/index.php?/topic/216274-wheat-why-its-not-good-29-of-americans-diet-is-wheat/page-2

Pathogen genomics and microbiota (8 entities) | Institut PasteurPathogen genomics and microbiota (8 entities) | Institut Pasteur

Bordetella Pertussis (Whooping Cough); Corynebacterium Diphtheriae (Diphtheria); Strain Taxonomies; Antibiotic Resistance; ... Carmen Buchrieser - Biology of Intracellular Bacteria. Legionella; Genomics; Virulence Factors; Cell Biology of Infection ... Klebsiella Pneumoniae (Urinary Tract, Respiratory and Blood Infections); Bordetella Pertussis (Whooping Cough); Corynebacterium ... Efficacy of cancer treatment: two bacteria in the microbiota identified. *Esrrb transcription factor plays a key role in ...
more infohttps://www.pasteur.fr/en/our-missions/strategic-plan-2019-2023/emerging-infectious-diseases/pathogen-genomics-and-microbiota-8-entities

Subtilase cytotoxin (SubAB) - CFGparadigmsSubtilase cytotoxin (SubAB) - CFGparadigms

... pertussis toxin (Ptx); and (iii) Shiga toxin (Stx). In each case, these AB5 toxins are key virulence factors of the bacteria ... pertussis toxin (Ptx) is produced by Bordetella pertussis, and shiga toxin (Stx) is produced by Shiga toxigenic E. coli (STEC) ... Bordetella pertussis (Ptx); Shiga toxigenic E. coli [STEC] and Shigella dysenteriae (Stx). A fourth sub-family, subtilise ...
more infohttp://functionalglycomics.org/CFGparadigms/index.php/Subtilase_cytotoxin_
  • In an attempt to gain insight into the genomic make-up of B. pertussis over the last 60 years, we used an oligonucleotide DNA microarray to compare the genomic contents of a collection of 171 strains of B. pertussis isolates from different countries. (biomedcentral.com)
  • Bordetella species, with the exception of B. petrii, are obligate aerobes, as well as highly fastidious, or difficult to culture. (wikipedia.org)
  • Bacteria initially adhere to ciliated epithelial cells in the nasopharynx, and this interaction with epithelial cells is mediated by a series of protein adhesins. (wikipedia.org)
  • Unlike most other Bordetella toxins, tracheal cytotoxin is expressed constitutively, being a normal product of the breakdown of the bacterial cell wall. (wikipedia.org)
  • The initial catarrhal phase of infection produces symptoms similar to those of the common cold, and during this period, large numbers of bacteria can be recovered from the pharynx. (wikipedia.org)
  • Thereafter, the bacteria proliferate and spread further into the respiratory tract, where the secretion of toxins causes ciliostasis and facilitates the entry of bacteria to tracheal/bronchial ciliated cells. (wikipedia.org)
  • The expression of many Bordetella adhesins and toxins is controlled by the two-component regulatory system BvgAS. (wikipedia.org)
  • Other bacteria recycle this molecule back into the cytoplasm, but in Bordetella and Neisseria gonorrhoeae, it is released into the environment. (wikipedia.org)
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