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BacteriorhodopsinsJervell-Lange Nielsen SyndromePatents as TopicEllis-Van Creveld SyndromeHistory, 19th CenturyBiotechnologyHistory, 20th CenturyLabial Frenum
Bacteriorhodopsins
Rhodopsins found in the PURPLE MEMBRANE of halophilic archaea such as HALOBACTERIUM HALOBIUM. Bacteriorhodopsins function as an energy transducers, converting light energy into electrochemical energy via PROTON PUMPS.
Jervell-Lange Nielsen Syndrome
A form of long QT syndrome that is associated with congenital deafness. It is characterized by abnormal cardioelectrophysiology involving the VOLTAGE-GATED POTASSIUM CHANNEL. It results from mutation of KCNQ1 gene (Subtype 1 or JLN1) or the KCNE1 gene (Subtype 2 or JLN2).
Patents as Topic
Exclusive legal rights or privileges applied to inventions, plants, etc.
Ellis-Van Creveld Syndrome
Dwarfism occurring in association with defective development of skin, hair, and teeth, polydactyly, and defect of the cardiac septum. (Dorland, 27th ed)
History, 19th Century
Time period from 1801 through 1900 of the common era.
Biotechnology
Body of knowledge related to the use of organisms, cells or cell-derived constituents for the purpose of developing products which are technically, scientifically and clinically useful. Alteration of biologic function at the molecular level (i.e., GENETIC ENGINEERING) is a central focus; laboratory methods used include TRANSFECTION and CLONING technologies, sequence and structure analysis algorithms, computer databases, and gene and protein structure function analysis and prediction.
History, 20th Century
Time period from 1901 through 2000 of the common era.
Labial Frenum

Location of a cation-binding site in the loop between helices F and G of bacteriorhodopsin as studied by 13C NMR. (1/1144)

The high-affinity cation-binding sites of bacteriorhodopsin (bR) were examined by solid-state 13C NMR of samples labeled with [3-13C]Ala and [1-13C]Val. We found that the 13C NMR spectra of two kinds of blue membranes, deionized (pH 4) and acid blue at pH 1.2, were very similar and different from that of the native purple membrane. This suggested that when the surface pH is lowered, either by removal of cations or by lowering the bulk pH, substantial change is induced in the secondary structure of the protein. Partial replacement of the bound cations with Na+, Ca2+, or Mn2+ produced additional spectral changes in the 13C NMR spectra. The following conclusions were made. First, there are high-affinity cation-binding sites in both the extracellular and the cytoplasmic regions, presumably near the surface, and one of the preferred cation-binding sites is located at the loop between the helix F and G (F-G loop) near Ala196, consistent with the 3D structure of bR from x-ray diffraction and cryoelectron microscopy. Second, the bound cations undergo rather rapid exchange (with a lifetime shorter than 3 ms) among various types of cation-binding sites. As expected from the location of one of the binding sites, cation binding induced conformational alteration of the F-G interhelical loop.  (+info)

Distortion of the L-->M transition in the photocycle of the bacteriorhodopsin mutant D96N: a time-resolved step-scan FTIR investigation. (2/1144)

The D96N mutant of bacteriorhodopsin has often been taken as a model system to study the M intermediate of the wild type photocycle due to the long life time of the corresponding intermediate of the mutant. Using time-resolved step-scan FTIR spectroscopy in combination with a sample changing wheel we investigated the photocycle of the mutant with microsecond time resolution. Already after several microseconds an intermediate similar to the MN state is observed, which contrasts with the M state of the wild type protein. At reduced hydration M and N intermediates similar to those of wild type BR can be detected. These results have a bearing on the interpretation of the photocycle of this mutant. A mechanism is suggested for the fast rise of MN which provides some insight into the molecular events involved in triggering the opening of the cytosolic channel also of the wild type protein.  (+info)

Molecular modeling of mu opioid receptor and receptor-ligand interaction. (3/1144)

AIM: To construct the 3D structural model of mu opioid receptor (mu OR) and study the interaction between mu OR and fentanyl derivatives. METHODS: The 3D structure of mu OR was modeled using the bacteriorhodopsin (bRh) as a template, in which the alignments of transmembrane (TM) of bRh and mu OR were achieved by scoring the alignment between the amino acid sequence of mu OR and the structure of bRh. The fentanyl derivatives were docked into the 7 helices of mu OR and the binding energies were calculated. RESULTS: (1) The receptor-ligand interaction models were obtained for fentanyl derivatives. (2) In these models, the fundamental binding sites were possibly Asp147 and His297. The negatively charged oxygen of Asp147 and the positively charged ammonium group of ligand formed the potent electrostatic and hydrogen-binding interactions. Whereas the interactions between the positively charged nitrogen of His297 and the carbonyl oxygen of ligand were weak. In addition, there were some pi-pi interactions between the receptor and the ligand. (3) The binding energies of the receptor-ligand complexes had a good correlation with the analgesic activities (-lg ED50) of the fentanyl derivatives. CONCLUSION: This model is helpful for understanding the receptor-ligand interaction and for designing novel mu OR selective ligands.  (+info)

Molecular modeling of interaction between delta opioid receptor and 3-methylfentanylisothiocyanate. (4/1144)

AIM: To construct a 3D structural model of delta opioid receptor (delta OR) and study its interaction with 3-methylfentanylisothiocyanate (SuperFIT). METHODS: Using the bacteriohodopsin as a template, the 3D structure of delta OR was modeled; SuperFIT was docked into its inside. RESULTS: The interaction model between delta OR and (3R, 4S)-SuperFIT was achieved, in which the important binding sites possibly were Asp128, Ser106, Phe104, Tyr308, and Pro315. Asp128 formed the electrostatic and hydrogen-binding interactions with the protonated nitrogen on piperidine of the ligand. Ser106 formed the electrostatic interaction with the N atom of isothiocyano group of the ligand; whereas Phe104, Tyr308, and Pro315 formed the hydrophobic interactions with the S atom of isothiocyano group. In addition, there were some other interactions between delta OR and the ligand. CONCLUSION: The residues Phe104, Tyr308, Pro315, and Ser106 of delta OR are crucial to the delta selectivity of the ligand, which is beneficial for designing novel delta-selective ligand.  (+info)

Interpretation of the spatial charge displacements in bacteriorhodopsin in terms of structural changes during the photocycle. (5/1144)

We have recently introduced a method, made possible by an improved orienting technique using a combination of electric and magnetic fields, that allows the three-dimensional detection of the intramolecular charge displacements during the photocycle of bacteriorhodopsin. This method generates electric asymmetry, a prerequisite for the detection of electric signal on the macroscopic sample, in all three spatial dimensions. Purple membrane fragments containing bacteriorhodopsin were oriented so that their permanent electric dipole moment vectors were perpendicular to the membrane plane and pointed in the same direction. The resulting cylindrical symmetry was broken by photoselection, i. e., by flash excitation with low intensity linearly polarized light. From the measured electric signals, the three-dimensional motion of the electric charge center in the bacteriorhodopsin molecules was calculated for the first 400 microseconds. Simultaneous absorption kinetic recording provided the time-dependent concentrations of the intermediates. Combining the two sets of data, we determined the discrete dipole moments of intermediates up to M. When compared with the results of current molecular dynamics calculations, the data provided a decisive experimental test for selecting the optimal theoretical model for the proton transport and should eventually lead to a full description of the mechanism of the bacteriorhodopsin proton pump.  (+info)

Simulation analysis of the retinal conformational equilibrium in dark-adapted bacteriorhodopsin. (6/1144)

In dark-adapted bacteriorhodopsin (bR) the retinal moiety populates two conformers: all-trans and (13,15)cis. Here we examine factors influencing the thermodynamic equilibrium and conformational transition between the two forms, using molecular mechanics and dynamics calculations. Adiabatic potential energy mapping indicates that whereas the twofold intrinsic torsional potentials of the C13==C14 and C15==N16 double bonds favor a sequential torsional pathway, the protein environment favors a concerted, bicycle-pedal mechanism. Which of these two pathways will actually occur in bR depends on the as yet unknown relative weight of the intrinsic and environmental effects. The free energy difference between the conformers was computed for wild-type and modified bR, using molecular dynamics simulation. In the wild-type protein the free energy of the (13,15)cis retinal form is calculated to be 1.1 kcal/mol lower than the all-trans retinal form, a value within approximately kBT of experiment. In contrast, in isolated retinal the free energy of the all-trans state is calculated to be 2.1 kcal/mol lower than (13,15)cis. The free energy differences are similar to the adiabatic potential energy differences in the various systems examined, consistent with an essentially enthalpic origin. The stabilization of the (13,15)cis form in bR relative to the isolated retinal molecule is found to originate from improved protein-protein interactions. Removing internal water molecules near the Schiff base strongly stabilizes the (13,15)cis form, whereas a double mutation that removes negative charges in the retinal pocket (Asp85 to Ala; Asp212 to Ala) has the opposite effect.  (+info)

Chloride ion binding to bacteriorhodopsin at low pH: an infrared spectroscopic study. (7/1144)

Bacteriorhodopsin (bR) and halorhodopsin (hR) are light-induced ion pumps in the cell membrane of Halobacterium salinarium. Under normal conditions bR is an outward proton transporter, whereas hR is an inward Cl- transporter. There is strong evidence that at very low pH and in the presence of Cl-, bR transports Cl- ions into the cell, similarly to hR. The chloride pumping activity of bR is connected to the so-called acid purple state. To account for the observed effects in bR a tentative complex counterion was suggested for the protonated Schiff base of the retinal chromophore. It would consist of three charged residues: Asp-85, Asp-212, and Arg-82. This quadruplet (including the Schiff base) would also serve as a Cl- binding site at low pH. We used Fourier transform infrared difference spectroscopy to study the structural changes during the transitions between the normal, acid blue, and acid purple states. Asp-85 and Asp-212 were shown to participate in the transitions. During the normal-to-acid blue transition, Asp-85 protonates. When the pH is further lowered in the presence of Cl-, Cl- binds and Asp-212 also protonates. The binding of Cl- and the protonation of Asp-212 occur simultaneously, but take place only when Asp-85 is already protonated. It is suggested that HCl is taken up in undissociated form in exchange for a neutral water molecule.  (+info)

Time-resolved absorption and photothermal measurements with sensory rhodopsin I from Halobacterium salinarum. (8/1144)

An expansion accompanying the formation of the first intermediate in the photocycle of transducer-free sensory rhodopsin I (SRI) was determined by means of time-resolved laser-induced optoacoustic spectroscopy. For the native protein (SRI-WT), the absolute value of the expansion is approximately 5.5 mL and for the mutant SRI-D76N, approximately 1.5 mL per mol of phototransformed species (in 0.5 M NaCl), calculated by using the formation quantum yield for the first intermediate (S610) of Phi610 = 0.4 +/- 0.05 for SRI-WT and 0.5 +/- 0.05 for SRI-D76N, measured by laser-induced optoacoustic spectroscopy and by laser flash photolysis. The similarity in Phi610 and in the determined value of the energy level of S610, E610 = (142 +/- 12) kJ/mol for SRI-WT and SRI-D76N indicates that Asp76 is not directly involved in the first step of the phototransformation. The increase with pH of the magnitude of the structural volume change for the formation of S610 in SRI-WT and in SRI-D76N upon excitation with 580 nm indicates also that amino acids other than Asp76, and other than those related to the Schiff base, are involved in the process. The difference in structural volume changes as well as differences in the activation parameters for the S610 decay should be attributed to differences in the rigidity of the cavity surrounding the chromophore. Except for the decay of the first intermediate, which is faster than in the SRI-transducer complex, the rate constants of the photocycle for transducer-free SRI in detergent suspension are strongly retarded with respect to wild-type membranes (this comparison should be done with great care because the preparation of both samples is very different).  (+info)

Effect of Asp85 replacement by Thr on the conformation, surface electric properties and stability of bacteriorhodopsin<...
TY - JOUR. T1 - Effect of Asp85 replacement by Thr on the conformation, surface electric properties and stability of bacteriorhodopsin. AU - Taneva, Stefka G.. AU - Gõi, Felix M.. AU - Tuparev, Nikolai P.. AU - Petkanchin, Ivana. AU - Dér, A.. AU - Muga, Arturo. PY - 2002/9/25. Y1 - 2002/9/25. N2 - The role of Asp85 in maintaining bacteriorhodopsin structure has been analyzed by infrared spectroscopy, electric light scattering and differential scanning calorimetry. In comparison with the wild type bacteriorhodopsin, the mutant protein D85T shows a different conformation, electric dipole moments and decreased thermal stability. The conformational rearrangements affect both the transmembrane helices and the extramembranous protein segments. Both electric dipoles - the permanent dipole moment and the electric polarizability - have drastically lower values for the membranes containing D85T variant of bacteriorhodopsin. Therefore, this single amino acid mutation not only changes bacteriorhodopsin ...
https://hungary.pure.elsevier.com/en/publications/effect-of-asp85-replacement-by-thr-on-the-conformation-surface-el
Early picosecond events in the photo cycle of BacteriorhodopsinEarly picosecond events in the photo cycle of Bacteriorhodopsin
The primary processes of the photochemical cycle of light-adapted bacteriorhodopsin (BR) were studied by various experimental techniques with a time resolution of 5 × 10-13 s. The following results were obtained. (a) After optical excitation the first excited singlet state S1 of bacteriorhodopsin is observed via its fluorescence and absorption properties. The population of the excited singlet state decays with a lifetime τ1 of ~0.7 ps (430 ± 50 fs) (52). (b) With the same time constant the first ground-state intermediate J builds up. Its absorption spectrum is red-shifted relative to the spectrum of BR by ~30 nm. (c) The second photoproduct K, which appears with a time constant of τ2 = 5 ps shows a red-shift of 20 nm, relative to the peak of BR. Its absorption remains constant for the observation time of 300 ps. (d) Upon suspending bacteriorhodopsin in D2O and deuterating the retinal Schiff base at its nitrogen (lysine 216), the same photoproducts J and K are observed. The relaxation time ...
https://epub.ub.uni-muenchen.de/3299/index.html
Femtosecond Infrared Spectroscopy of Bacteriorhodopsin Chromophore Isomerization | ScienceFemtosecond Infrared Spectroscopy of Bacteriorhodopsin Chromophore Isomerization | Science
The vibrational dynamics of the retinal chromophore all-trans-to-13-cis photoisomerization in bacteriorhodopsin has been studied with mid-infrared absorption spectroscopy at high time resolution (about 200 femtoseconds). After photoexcitation of light-adapted bacteriorhodopsin, the transient infrared absorption was probed in a broad spectral region, including vibrations with dominant C-C, C=C, and C=NH stretching mode amplitude. All photoproduct modes, especially those around 1190 reciprocal-centimeters that are indicative for a 13-cis configuration of the chromophore, rise with a time constant of ∼0.5 picosecond. The results presented give direct vibrational-spectroscopic evidence for the isomerization taking place within 0.5 picosecond, as has been suggested by previous optical femtosecond time-resolved experiments but questioned recently by picosecond time-resolved vibrational spectroscopy experiments. ...
https://science.sciencemag.org/content/297/5582/822
SFB Publication in Communications Biology • Sonderforschungsbereich 1078SFB Publication in Communications Biology • Sonderforschungsbereich 1078
Chemical exchange of hydrogen atoms is the basis for many biological processes, including energy conversion from light into chemical potentials. In a recent collaborative study of the SFB 1078 under the direction of Hartmut Oschkinat (B1), Peter Hegemann (B1, B2) and Roland R. Netz (C1), proton exchange was detected and characterized in the light-driven proton pump bacteriorhodopsin, a well-established model system for protonation dynamics studies. The work, published in the new open access journal Communications Biology of the Nature Publishing Group, revealed that reversible proton translocation occurs even in the dark-state of the protein, involving the retinal Schiff base and D85 exchanging protons with H2O. The authors find evidence of an active site proton cage and possible proton transfer via R82. The experimental observations have been corroborated by theoretical approaches, further extending the general understanding of proton exchange in proteins.. Friedrich, D., Brünig, F. N., ...
http://www.sfb1078.de/news/200116_CommBiol.html
Chapter 7: Molecular Computation
Biological molecules and assemblies, such as the photochemical reaction center, are capable of capturing light with good quantum efficiency and transforming it into chemical energy. If properly exploited, such assemblies have potential applications as biomolecule information processing units.. Bacteriorhodopsin, from the purple membrane bacterium Halobacterium halobium, is one such system that has been studied extensively and has been commercialized into optical holographic memories (Birge 1995). In the bacterium, the protein bacteriorhodopsin self-assembles into ordered lipid patches. The protein absorbs light and undergoes a cycle involving a complex series of intermediates, resulting in a proton being pumped across the membrane. It was information developed from understanding the basic science behind the way that bacteriorhodopsin works that led to the use of bacteriorhodopsin as a biomolecule information processing unit. To be used for information storage, the protein is placed under ...
http://www.wtec.org/loyola/nano/07_05.htm
Structure of bacteriorhodopsin at 1.55 A resolutionStructure of bacteriorhodopsin at 1.55 A resolution
Th?e atomic structure of the light-driven ion pump bacteriorhodopsin and the surrounding lipid matrix was determined by X-ray diffraction of crystals grown in cubic lipid phase. In the extracellular region, an extensive three-dimensional hydrogen-bonded network of protein residues and seven water mo …
https://pubmed.ncbi.nlm.nih.gov/10452895/
Molecular Mechanism of Long-range Proton Translocation by BacteriorhodopsinMolecular Mechanism of Long-range Proton Translocation by Bacteriorhodopsin
The transmembrane electrochemical proton gradient is a key source of cellular energy. Bacteriorhodopsin (bR), the simplest and most studied proton pump, moves protons from low to high concentration by harnessing light energy, creating the transmembrane el
http://www.jbsdonline.com/molecular-mechanism-long-range-proton-translocation-bacteriorhodopsin-p18792.html
RCSB PDB - 1DZE: Structure of the M Intermediate of Bacteriorhodopsin trapped at 100K Macromolecule Annotations PageRCSB PDB - 1DZE: Structure of the M Intermediate of Bacteriorhodopsin trapped at 100K Macromolecule Annotations Page
1DZE: Crystal Structure of the M Intermediate of Bacteriorhodopsin: Allosteric Structural Changes Mediated by Sliding Movement of a Transmembrane Helix
http://www.rcsb.org/pdb/explore/derivedData.do?structureId=1DZE
Publications | Laser Dynamics Lab
Heyes CD, EL-Sayed MA. Proton transfer reactions in native and deionized bacteriorhodopsin upon delipidation and monomerization. Biophysical journal [Internet]. 2003 ;85(1):426-434. Available from: http://dx.doi.org/10.1016/S0006-3495(03)74487-7 ...
https://ldl.gatech.edu/publications?s=type&%3Bf%5Bag%5D=E&f%5Bauthor%5D=154&o=desc
5h2l.1 | SWISS-MODEL Template Library
SWISS-MODEL Template Library (SMTL) entry for 5h2l.1. A three dimensional movie of structural changes in bacteriorhodopsin: structure obtained 5.25 us after photoexcitation
https://swissmodel.expasy.org/templates/5h2l.1
3-Fluoro-DL-tyrosine | GoldBio3-Fluoro-DL-tyrosine | GoldBio
3-Fluoro-DL-tyrosine can be used to study how halogenated tyrosines affect proteins such as bacteriorhodopsin, microvillar enzymes, and β-galactosidases.
https://www.goldbio.com/product/117994/3-fluoro-dl-tyrosine
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Recerca: tesisRecerca: tesis
Classical planning is the problem of finding a sequence of actions, from a given initial state to some goal state. While, in generalized planning, a plan is a solution to a set of planning problems, which belong to the ...
https://repositori.upf.edu/handle/10230/4?locale-attribute=ca
Gen X the only generation to rebound from Great Recession in wealth | Pew Research CenterGen X the only generation to rebound from Great Recession in wealth | Pew Research Center
Crystal structure of Escherichia coli-expressed Haloarcula marismortui bacteriorhodopsin I in the trimeric form.
Bacteriorhodopsins are a large family of seven-helical transmembrane proteins that function as light-driven proton pumps. Here, we present the crystal structure of a new member of the family, Haloarcula marismortui bacteriorhodopsin I (HmBRI) D94N mutant, at the resolution of 2.5 Å. While the HmBRI retinal-binding pocket and proton donor site are similar to those of other archaeal proton pumps, its proton release region is extended and contains additional water molecules. The proteins fold is reinforced by three novel inter-helical hydrogen bonds, two of which result from double substitutions relative to Halobacterium salinarum bacteriorhodopsin and other similar proteins. Despite the expression in Escherichia coli and consequent absence of native lipids, the protein assembles as a trimer in crystals. The unique extended loop between the helices D and E of HmBRI makes contacts with the adjacent protomer and appears to stabilize the interface. Many lipidic hydrophobic tail groups are discernible in the
http://hal.univ-grenoble-alpes.fr/hal-01130643
Characterization of a halobacterial gene affecting bacterio-opsin gene expression. - TUbiblioCharacterization of a halobacterial gene affecting bacterio-opsin gene expression. - TUbiblio
A substantial number of spontaneous bacterio-opsin mutants of Halobacterium halobium are the result of insertion elements up to 1400 bp upstream of the bacterio-opsin (bop) gene. The nucleotide sequence of 1800 bp upstream of the bop gene has been determined. There is a 1118 bp open reading frame (ORF) located within this region which is transcribed and which coincides with the distribution of insertion elements upstream of the bop gene in Bop mutants. Therefore, we propose that there is a gene (brp gene) 526 bp upstream of the bop gene. This putative gene is transcribed in the opposite direction as the bop gene and could encode a protein of 37,500 D (359 amino acids) with a codon usage similar to bacterio-opsin. The 5 terminus of the brp transcript has been determined. The brp transcript and the bop mRNA are complementary for 13 residues near their 5 termini and both transcripts start at or near the initiating codon of the gene. Both transcripts could form similar hairpin loop structures at ...
http://tubiblio.ulb.tu-darmstadt.de/49061/
Photocurrent generation based on a light-driven proton pump in an artificial liquid membrane | USC Research Bank - University...Photocurrent generation based on a light-driven proton pump in an artificial liquid membrane | USC Research Bank - University...
Biological light-driven proton pumps use light to move protons across a cell membrane, creating a proton gradient. Although photochromic compounds such as spiropyrans can reversibly convert between two structures with differing pKa values, spiropyrans have not been used to generate either a light-driven proton pump or an electrical current. Here, we report an artificial light-harvesting system based on a supported liquid membrane doped with a spiropyran. Irradiating the membrane with ultraviolet light induces a ring-opening reaction, converting spiropyran to merocyanine, whereas irradiation with visible light induces the reverse reaction. When the membrane is irradiated with ultraviolet and visible light on opposite sides, H+ is taken up by merocyanine, carried through the polymeric membrane and released on the other side. We show that this system produces a light-induced proton flux, an electrical current with an efficiency of ~0.12%, an open-circuit voltage of ~210 mV and a membrane gradient of ~3.6
http://research.usc.edu.au/vital/access/manager/Repository/usc:12601
Publications | Laser Dynamics Lab
Heyes CD, Wang J, Sanii LS, EL-Sayed MA. Fourier transform infrared study of the effect of different cations on bacteriorhodopsin protein thermal stability. Biophysical journal [Internet]. 2002 ;82(3):1598-1606. Available from: http://dx.doi.org/10.1016/S0006-3495(02)75511-2 ...
https://ldl.gatech.edu/publications?page=4&s=title&%3Bf%5Bag%5D=R&f%5Bauthor%5D=154&o=asc
Bio-Compatible Hybrid Organic/Inorganic Gels: Vapor Phase Synthesis - Patent applicationBio-Compatible Hybrid Organic/Inorganic Gels: Vapor Phase Synthesis - Patent application
0070]Bacteriorhodopsin (purple membrane) has been incorporated in liposomes using sonication. The lipid mixture used was 4:1 DOPE: EggPC. DOPE has been shown to increase the incorporation of bacteriorhodopsin (bR). 10 mM pH buffer was used so that we could see the change in pH due to bacteriorhodopsin. After gelation, a few drops of buffer were added to the sample if the pH was not stable, for example due to improper contact with the pH electrode. The pH levels of gels containing the bR-incorporated lipsomes before and after light exposure were measured and compared with the pH levels of blank-liposomes in gel before and after light exposure. Light with a yellow light filter was shined for 30 sec and a break for 60 sec was given. This was due to the fact that the blank-liposome gel in buffer was showing a slight decrease in pH, which was suspected to be due to a heat effect. The pH levels of the blank returned to baseline after exposure to light, whereas the pH levels of the bR-incorporated ...
http://www.patentsencyclopedia.com/app/20080311391
Difference between revisions of CH391L/S13/Optogenetics - OpenWetWareDifference between revisions of CH391L/S13/Optogenetics - OpenWetWare
The story behind optogenetics is a story of convergence of two seemingly unrelated fields: microbial microbiology and neuroscience. In 1971, Walther Stoeckenius and Dieter Oesterhelt discovered the transmembrane protein bacteriorhodopsin (BR) that is capable of moving ions in the presence of light. BR is highly expressed in haloarcheal membranes while a similar transmembrane protein proteorhodopsin (PR) is expressed in eubacteria. In 1977, Matsuno-Yagi and Mukohata described the ion pump channel halorhodopsin which displaces extracellular chloride ions in to the cell. As these discoveries were happening in the background, a growing desire to effectively control the neurons was ever -prevalent. During this period, neuroscientist adopted the idea that cognitive processes were distributed in various localizations of the cortex. This fact evident when lesions in specific areas would lead to loss of a specific process. Even fMRIs and PET solidified this point, but, even with these high-tech ...
https://openwetware.org/wiki/?title=CH391L/S13/Optogenetics&diff=prev&oldid=679208
Difference between revisions of CH391L/S13/Optogenetics - OpenWetWareDifference between revisions of CH391L/S13/Optogenetics - OpenWetWare
The story behind optogenetics is a story of convergence of two seemingly unrelated fields: microbial microbiology and neuroscience. In 1971, Walther Stoeckenius and Dieter Oesterhelt discovered the transmembrane protein bacteriorhodopsin (BR) that is capable of moving ions in the presence of light. BR is highly expressed in haloarcheal membranes while a similar transmembrane protein proteorhodopsin (PR) is expressed in eubacteria. In 1977, Matsuno-Yagi and Mukohata described the ion pump channel halorhodopsin which displaces extracellular chloride ions in to the cell. As these discoveries were happening in the background, a growing desire to effectively control the neurons was ever -prevalent. During this period, neuroscientist adopted the idea that cognitive processes were distributed in various localizations of the cortex. This fact evident when lesions in specific areas would lead to loss of a specific process. Even fMRIs and PET solidified this point, but, even with these high-tech ...
https://openwetware.org/wiki/?title=CH391L/S13/Optogenetics&diff=679046&oldid=679040
Sequence Similarity - 1BCT: THREE-DIMENSIONAL STRUCTURE OF PROTEOLYTIC FRAGMENT 163-231 OF BACTERIOOPSIN DETERMINED...Sequence Similarity - 1BCT: THREE-DIMENSIONAL STRUCTURE OF PROTEOLYTIC FRAGMENT 163-231 OF BACTERIOOPSIN DETERMINED...
1BCT: Three-dimensional structure of proteolytic fragment 163-231 of bacterioopsin determined from nuclear magnetic resonance data in solution.
http://www.rcsb.org/pdb/explore/sequenceCluster.do?structureId=1BCT
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Index of /Evolution/archaea
Parent Directory - phylogenetictree.jpg 20-Jul-2014 00:42 24K phylogenetictree-t.jpg 20-Jul-2014 00:42 7.0K Bacteriorhodopsin/ 20-Jul-2014 00:42 - Archaeacells.htm 20-Jul-2014 00:42 965 ...
http://www.fossilmuseum.net/Evolution/archaea/?C=D
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HEPDataHEPData
https://inspirehep.net/literature/892684 Inspire Record 892684 DOI 10.17182/hepdata.62222 https://doi.org/10.17182/hepdata.62222 We study the processes e+e- --, K+ K- pi+pi-gamma, K+ K- pi0pi0gamma, and K+ K- K+ K-gamma, where the photon is radiated from the initial state. About 84000, 8000, and 4200 fully reconstructed events, respectively, are selected from 454 fb-1 of BaBar data. The invariant mass of the hadronic final state defines the \epem center-of-mass energy, so that the K+ K- pi+pi- data can be compared with direct measurements of the e+e- --, K+ K- pi+pi- reaction. No direct measurements exist for the e+e- --, K+ K-pi0pi0 or e+e- --, K+ K-K+ K- reactions, and we present an update of our previous result with doubled statistics. Studying the structure of these events, we find contributions from a number of intermediate states, and extract their cross sections. In particular, we perform a more detailed study of the e+e- --, phi(1020)pipigamma reaction, and confirm the presence of the ...
https://www.hepdata.net/search/?q=cmenergies%3A%5B1.3+TO+1.4%5D&author=Posocco%2C+M.&page=1
DE3638654A1 - Testtraeger for the analytical determination of a component of a body fluid - Google Patents
Die Erfindung betrifft einen Testträger zur analytischen Bestim mung eines Bestandteils einer Körperflüssigkeit mit einer Basis schicht und mindestens zwei flachen im Ausgangszustand des Test trägers vor Durchführung einer Bestimmung voneinander getrennten, jedoch durch externe Manipulation in Kontakt zueinander bringbaren Testschichten. The invention relates to a test carrier for the analytical Bestim mung a component of a body fluid with a base layer and at least two flat in the initial state of the test carrier prior to making a determination on separate, but mutually by external manipulation can be brought into contact test layers. Während früher im klinischen Labor die Konzentration beispiels weise der Bestandteile des Blutes praktisch ausschließlich mit Hilfe flüssiger Reagenzien bestimmt wurde, haben in jüngerer Zeit sogenannte trägergebundene Tests zunehmend an Bedeutung gewonnen. While earlier in the clinical laboratory, the concentration example, the components of the blood ...
https://patents.google.com/patent/DE3638654A1/en
The long way around - Deep Purple ~ Traduzione e testoThe long way around - Deep Purple ~ Traduzione e testo
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https://canzonimetal.altervista.org/the-long-way-around-deep-purple/
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Light-driven Na+ pump from Gillisia limnaea: A high-affinity Na+ binding site is formed transiently in the photocycle (Journal...Light-driven Na+ pump from Gillisia limnaea: A high-affinity Na+ binding site is formed transiently in the photocycle (Journal...
A group of microbial retinal proteins most closely related to the proton pump xanthorhodopsin has a novel sequence motif and a novel function. Instead of, or in addition to, proton transport, they perform light-driven sodium ion transport, as reported for one representative of this group (KR2) from Krokinobacter. In this paper, we examine a similar protein, GLR from Gillisia limnaea, expressed in Escherichia coli, which shares some properties with KR2 but transports only Na +. The absorption spectrum of GLR is insensitive to Na + at concentrations of ≤3 M. However, very low concentrations of Na + cause profound differences in the decay and rise time of photocycle intermediates, consistent with a switch from a Na +-independent to a Na +-dependent photocycle (or photocycle branch) at ~60 μM Na +. The rates of photocycle steps in the latter, but not the former, are linearly dependent on Na + concentration. This suggests that a high-affinity Na + binding site is created transiently after ...
https://www.osti.gov/pages/biblio/1165228-light-driven-na-pump-from-gillisia-limnaea-high-affinity-na-binding-site-formed-transiently-photocycle
Specific arginine and threonine residues control anion binding and transport in the light‐driven chloride pump halorhodopsin |...
In a general description of the various ion transport modes found for halobacterial retinal proteins (Haupts et al., 1997), the transport mechanism is represented by a sequence of six principal reaction steps: retinal isomerization to 13‐cis or all‐trans (either photochemical, designated as I*, or thermal, I), ion translocation to or from the Schiff base (T) and switch of the Schiff base accessibility towards the EC or CP side (S). Within this framework, the anion transport mechanism of wild type HR, taking into consideration the results on specific mutants, can be described as follows (Figure 7): in the initial state, the substrate anion occupies a binding site constituted by R108 and T111, also interacting with the protonated Schiff base (Walter and Braiman, 1994), and the Schiff base is accessible for ions from the EC side. (1) Light‐induced isomerization (I*) is followed by (2) translocation of this anion towards the Schiff base (T), where it is located in the HR520 intermediate state ...
http://emboj.embopress.org/content/16/13/3813
Thermophilic archaea activate butane via alkyl-coenzyme M formation. :: MPG.PuReThermophilic archaea activate butane via alkyl-coenzyme M formation. :: MPG.PuRe
Author: Laso-Pérez, R. et al.; Genre: Journal Article; Published in Print: 2016-11-17; Open Access; Keywords: Archaeal physiology; Metabolomics; Environmental microbiology|br/|; Title: Thermophilic archaea activate butane via alkyl-coenzyme M formation.
https://pure.mpg.de/pubman/faces/ViewItemFullPage.jsp?itemId=item_2375256
Purification and properties of serine protease from Halobacterium halobium. | Journal of BacteriologyPurification and properties of serine protease from Halobacterium halobium. | Journal of Bacteriology
Pure extracellular serine protease was isolated from the culture filtrate of Halobacterium halobium by bacitracin-Sepharose affinity chromatography. The enzyme activity was completely and irreversibly lost if the NaCl concentration fell below 2 M. The protease consists of one polypeptide chain with a molecular weight of 41,000. It is characteristically enriched in Asx and Glx content, whereas the level of basic amino acids in the enzyme molecule is unusually low. The protease shows a preference for leucine in the carboxylic side of the scissile bond of the substrate, cleaving the B-chain of oxidized bovine insulin only at the Leu15-Tyr16 bond and liberating p-nitroaniline from L-pyroglutamyl-L-alanyl-L-alanyl-L-leucine-p-nitroanilide. ...
https://jb.asm.org/content/155/2/826
Faculty Collaboration Database - Molecular organization and dynamics in bacteriorhodopsin-rich reconstituted membranes:...Faculty Collaboration Database - Molecular organization and dynamics in bacteriorhodopsin-rich reconstituted membranes:...
Molecular organization and dynamics in protein-rich membranes have been studied by investigating transport (diffusion-concentration product) of molecular oxygen at various locations in reconstituted membranes of bacteriorhodopsin (BR) and L-alpha-dimyristoylphosphatidylcholine. Oxygen transport was evaluated by monitoring the bimolecular collision of molecular oxygen with four types of nitroxide lipid spin labels placed at various locations in the membrane. The collision rate was estimated from the spin-lattice relaxation times (T1s) measured at various oxygen partial pressures by analyzing the short-pulse saturation recovery ESR signals. CD spectra and decay of polarized flash-induced photodichroism of bacteriorhodopsin indicated that BR molecules are monomers in reconstituted membranes with a lipid/BR molar ratio of 80 (80-rec) and are 25% monomers and 75% trimers plus oligomers of trimers when the lipid/BR ratio is 40 (40-rec). In the 80-rec, the lipid environment is homogeneous on a ...
https://fcd.mcw.edu/?search/showPublication/id/17953
Phototransduction by Vertebrate Ultraviolet Visual Pigments: Protonation of the Retinylidene Schiff Base following...Phototransduction by Vertebrate Ultraviolet Visual Pigments: Protonation of the Retinylidene Schiff Base following...
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https://www.infona.pl/resource/bwmeta1.element.acs-doi-10_1021_bi025883g
All-optical nonlinear holographic correlation using bacteriorhodopsin filmsAll-optical nonlinear holographic correlation using bacteriorhodopsin films
The flagship monthly journal of SPIE, |i|Optical Engineering|/i| (OE) publishes peer-reviewed papers reporting on research and development in all areas of optics, photonics, and imaging science and engineering.
https://www.spiedigitallibrary.org/journals/Optical-Engineering/volume-34/issue-5/0000/All-optical-nonlinear-holographic-correlation-using-bacteriorhodopsin-films/10.1117/12.201654.short
Structure-function studies on mutants of adrenal ferredoxin - MDC RepositoryStructure-function studies on mutants of adrenal ferredoxin - MDC Repository
Adrenodoxin, Escherichia Coli, Kinetics, Molecular Cloning, Point Mutation, Polymerase Chain Reaction, Protein Binding, Recombinant Proteins, Structure-Activity ...
http://edoc.mdc-berlin.de/1626/
Electrostatic Environment of Proteorhodopsin Affects the pKa of Its Buried Primary Proton Acceptor | Institute for...Electrostatic Environment of Proteorhodopsin Affects the pKa of Its Buried Primary Proton Acceptor | Institute for...
The protonation state of embedded charged residues in transmembrane proteins (TMPs) can control the onset of protein function. It is understood that interactions between an embedded charged residue and other charged or polar residues in the moiety would influence its pKa, but how the surrounding environment in which the TMP resides affects the pKa of these residues is unclear.
https://www.icb.ucsb.edu/publications/2916
WPI, QCC to Share $4M State Grant for Joint Integrated Photonics Lab | Business | Jan 2018 | Photonics.comWPI, QCC to Share $4M State Grant for Joint Integrated Photonics Lab | Business | Jan 2018 | Photonics.com
Worcester Polytechnic Institute (WPI) and Quinsigamond Community College (QCC) have been awarded a $4 million grant by the Commonwealth of Massachuset
https://www.photonics.com/a62995/WPI_QCC_to_Share_4M_State_Grant_for_Joint
Asymmetric Photoreactions of Conjugated Enones and EstersAsymmetric Photoreactions of Conjugated Enones and Esters
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Post-doctoral position in Structural Biology of Cilia, Astbury Centre, Leeds, UK - InstructPost-doctoral position in Structural Biology of Cilia, Astbury Centre, Leeds, UK - Instruct
A post-doctoral position is available immediately in the laboratory of Dr Joe Cockburn, at the Astbury Centre, University of Leeds, UK to perform structure-function studies on ciliary proteins.. The position is funded by The Wellcome Trust and is available immediately for a period of 24 months. The start date is flexible but must be before September 2017.. The deadline for applications is Monday 16th January 2017.. More information about the position and how to apply can be found here. ...
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10 Difference Between Reversible And Irreversible Process In Thermodynamics - Viva Differences10 Difference Between Reversible And Irreversible Process In Thermodynamics - Viva Differences
In thermodynamic, an irreversible process is defined as a process that cannot be reversed, the process cannot return both the system and the surroundings to their original conditions. During irreversible process, the entropy of the system increases rapidly and it cannot be reduced back to its initial value. During the irreversible process the various states of the system on the path of change from initial state to final state are not in equilibrium with each other. There are many factors that make a process irreversible, they include:. ...
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BacteriorhodopsinBacteriorhodopsin
... is a protein used by Archaea, most notably by haloarchaea, a class of the Euryarchaeota. It acts as a proton ... Bacteriorhodopsin is a light-driven proton pump. It is the retinal molecule that changes its isomerization state from all-trans ... Both rhodopsin and bacteriorhodopsin belong to the 7TM receptor family of proteins, but rhodopsin is a G protein-coupled ... Bacteriorhodopsin has a broad excitation spectrum. For a detection wavelength between 700 and 800 nm, it has an appreciable ...
https://en.wikipedia.org/wiki/Bacteriorhodopsin
ArchaeaArchaea
Lanyi JK (2004). "Bacteriorhodopsin". Annual Review of Physiology. 66: 665-88. doi:10.1146/annurev.physiol.66.032102.150049. ... In the Halobacteria, light-activated ion pumps like bacteriorhodopsin and halorhodopsin generate ion gradients by pumping ions ... "Molecular mechanism of vectorial proton translocation by bacteriorhodopsin". Nature. 406 (6796): 653-57. Bibcode:2000Natur.406 ...
https://en.wikipedia.org/wiki/Archaea
Proton pumpProton pump
Bacteriorhodopsin is a light-driven proton pump used by Archaea, most notably in Haloarchaea. Light is absorbed by a retinal ... The energy required for the proton pumping reaction may come from light (light energy; bacteriorhodopsins), electron transfer ( ...
https://en.wikipedia.org/wiki/Proton_pump
Model lipid bilayerModel lipid bilayer
"Unfolding pathways of individual bacteriorhodopsins". Science. 288 (5463): 143-6. Bibcode:2000Sci...288..143O. doi:10.1126/ ...
https://en.wikipedia.org/wiki/Model_lipid_bilayer
Lysosomal cystine transporter familyLysosomal cystine transporter family
Alignment of bacteriorhodopsins with the yeast sequence YRO2". Pharm. Res. 14 (11): 1533-41. doi:10.1023/a:1012166015402. PMID ...
https://en.wikipedia.org/wiki/Lysosomal_cystine_transporter_family
RetinalRetinal
All-trans-retinal is also an essential component of microbial opsins such as bacteriorhodopsin, channelrhodopsin, and ... Waschuk, Stephen A.; Bezerra, Arandi G.; Shi, Lichi; Brown, Leonid S. (2005). "Leptosphaeria rhodopsin: Bacteriorhodopsin-like ... Ovchinnikov, Yu.A. (8 November 1982). "Rhodopsin and bacteriorhodopsin: structure-function relationships". FEBS Letters. 148 (2 ... "All-trans to 13-cis retinal isomerization in light-adapted bacteriorhodopsin at acidic pH". Journal of Photochemistry and ...
https://en.wikipedia.org/wiki/Retinal
RhodopsinRhodopsin
See also bacteriorhodopsin, used in some halobacteria as a light-driven proton pump. Humphries P, Kenna P, Farrar GJ (May 1992 ... Ovchinnikov, Yu.A. (November 1982). "Rhodopsin and bacteriorhodopsin: structure-function relationships". FEBS Letters. 148 (2 ... "Characterization of the primary photochemical events in bacteriorhodopsin and rhodopsin". In Lee AG (ed.). Rhodopsin and G- ...
https://en.wikipedia.org/wiki/Rhodopsin
Har Gobind KhoranaHar Gobind Khorana
After the middle of the 1970s, his lab studied the biochemistry of bacteriorhodopsin, a membrane protein that converts light ... Wildenauer, D.; Khorana, H. G. (1977). "The preparation of lipid-depleted bacteriorhodopsin". Biochimica et Biophysica Acta ( ...
https://en.wikipedia.org/wiki/Har_Gobind_Khorana
OpsinOpsin
Among the many kinds of microbial opsins are the proton pumps bacteriorhodopsin (BR) and xanthorhodopsin (xR), the chloride ... Waschuk SA, Bezerra AG, Shi L, Brown LS (May 2005). "Leptosphaeria rhodopsin: bacteriorhodopsin-like proton pump from a ... doi:10.1016/S1043-9471(05)80049-7. Ovchinnikov, Yu.A. (November 1982). "Rhodopsin and bacteriorhodopsin: structure-function ... and bacteriorhodopsin, are used by various bacterial groups to harvest energy from light to carry out metabolic processes using ...
https://en.wikipedia.org/wiki/Opsin
Coherent controlCoherent control
Prokhorenko, V. I. (2006-09-01). "Coherent Control of Retinal Isomerization in Bacteriorhodopsin". Science. 313 (5791): 1257- ...
https://en.wikipedia.org/wiki/Coherent_control
Dieter OesterheltDieter Oesterhelt
After returned to Germany, Oesterhelt showed that physiological function of bacteriorhodopsin is to pump protons out of the ... This protein was isolated and called bacteriorhodopsin. ...
https://en.wikipedia.org/wiki/Dieter_Oesterhelt
Microbial rhodopsinMicrobial rhodopsin
... known today as bacteriorhodopsin. The first bacteriorhodopsin turned out to be of archaeal origin, from Halobacterium salinarum ... Bacteriorhodopsin also lacks the omega loop structure that has been observed at the N-terminus of the structures of several ... Bacteriorhodopsin pumps one Cl− ion, from the extracellular medium into the cytosol, per photon absorbed. Although the ions ... They differ from bacteriorhodopsin in that the claret membrane, in which they are expressed, includes bacterioruberin, a second ...
https://en.wikipedia.org/wiki/Microbial_rhodopsin
ProteorhodopsinProteorhodopsin
... by a mechanism similar to that of bacteriorhodopsin. As in bacteriorhodopsin, the retinal chromophore of proteorhodopsin is ... Bacteriorhodopsin was discovered in 1971 and named in 1973 and is currently only known to exist in the archea domain, not ... Bacteriorhodopsin and Halorhodopsin both only exist in the Archea domain whereas proteorhodopsin spans bacteria, archea, and ... In comparison with its better-known archaeal homolog bacteriorhodopsin, most of the active site residues of known importance to ...
https://en.wikipedia.org/wiki/Proteorhodopsin
R. J. Dwayne MillerR. J. Dwayne Miller
"Coherent Control of Retinal Isomerization in Bacteriorhodopsin". Science. 313 (5791): 1257-1261. Bibcode:2006Sci...313.1257P. ...
https://en.wikipedia.org/wiki/R._J._Dwayne_Miller
Pyroglutamic acidPyroglutamic acid
Pyroglutamate is found in many proteins including bacteriorhodopsin. N-terminal glutamic acid and glutamine residues can ...
https://en.wikipedia.org/wiki/Pyroglutamic_acid
Site-directed spin labelingSite-directed spin labeling
2. Spin labeling of bacteriorhodopsin mutants at unique cysteines". Biochemistry. 28 (19): 7806-7812. doi:10.1021/bi00445a042. ... Spin Labeling of Bacteriorhodopsin Mutants". Science. 248 (4959): 1088-192. Bibcode:1990Sci...248.1088A. doi:10.1126/science. ...
https://en.wikipedia.org/wiki/Site-directed_spin_labeling
HalobacteriaceaeHalobacteriaceae
Large blooms appear reddish, from the pigment bacteriorhodopsin. This pigment is used to absorb light, which provides energy to ...
https://en.wikipedia.org/wiki/Halobacteriaceae
HalobacterialesHalobacteriales
Large blooms appear reddish, from the pigment bacteriorhodopsin. This pigment is used to absorb light, which provides energy to ...
https://en.wikipedia.org/wiki/Halobacteriales
Spizellomyces punctatusSpizellomyces punctatus
Waschuk SA, Bezerra AG, Shi L, Brown LS (May 2005). "Leptosphaeria rhodopsin: bacteriorhodopsin-like proton pump from a ...
https://en.wikipedia.org/wiki/Spizellomyces_punctatus
Photoacoustic effectPhotoacoustic effect
Another case for this mechanism is Bacteriorhodopsin proton pump. Here the light induced change in the molecular volume is ... "Photoinduced volume changes associated with the early transformations of bacteriorhodopsin: A laser-induced optoacoustic ...
https://en.wikipedia.org/wiki/Photoacoustic_effect
PhototaxisPhototaxis
Some examples are bacteriorhodopsin and bacteriophytochromes in some bacteria. See also: phytochrome and phototropism. Most ...
https://en.wikipedia.org/wiki/Phototaxis
Bis-tris propaneBis-tris propane
Tóth-Boconádi R, Dér A, Keszthelyi L (June 2000). "Buffer effects on electric signals of light-excited bacteriorhodopsin". ...
https://en.wikipedia.org/wiki/Bis-tris_propane
Electrochemical gradientElectrochemical gradient
The way bacteriorhodopsin generates a proton gradient in Archaea is through a proton pump. The proton pump relies on proton ... Finally, bacteriorhodopsin returns to its resting state when Asp85 releases its proton to Glu204. PSII also relies on light to ... In bacteriorhodopsin, the proton pump is activated by absorption of photons of 568 nm wavelength which leads to isomerization ... This section will focus on three processes that help establish proton gradients in their respective cells: bacteriorhodopsin ...
https://en.wikipedia.org/wiki/Electrochemical_gradient
Baruch FischerBaruch Fischer
He also worked on wave mixing in Bacterio-Rhodopsin, fiber-optics and fiber-optic communications, pulse optics, a new tunable ... "Strong self-defocusing effect and four-wave mixing in bacteriorhodopsin films". Optics Letters. 17 (4): 241-243. Bibcode: ... and phase conjugation with bacteriorhodopsin". Optics Letters. 15 (20): 1117-1119. Bibcode:1990OptL...15.1117W. doi:10.1364/OL. ...
https://en.wikipedia.org/wiki/Baruch_Fischer
Laura EisensteinLaura Eisenstein
Váró, G.; Eisenstein, L. (1987). "Infrared studies of water induced conformational changes in bacteriorhodopsin". European ... bacteriorhodopsin and rhodopsin. This effort would engage and foster collaborations with scientists including Tom Ebrey, Koiji ...
https://en.wikipedia.org/wiki/Laura_Eisenstein
Bacterial motilityBacterial motility
Some examples are bacteriorhodopsin and bacteriophytochromes in some bacteria. See also: phytochrome and phototropism. Most ... At least some aspects of this response are likely mediated by changes in membrane potential by bacteriorhodopsin, a light- ... "Delta psi-mediated signalling in the bacteriorhodopsin-dependent photoresponse". Journal of Bacteriology. 178 (11): 3008-3014. ...
https://en.wikipedia.org/wiki/Bacterial_motility
George W. RayfieldGeorge W. Rayfield
Herrmann, T. R.; Rayfield, G. W. (1978-02-01). "The electrical response to light of bacteriorhodopsin in planar membranes". ... Simmeth, R.; Rayfield, G. W. (1990-05-01). "Evidence that the photoelectric response of bacteriorhodopsin occurs in less than 5 ... for extensive studies on the optical and electrical properties of bacteriorhodopsin, and ensuing device applications." "George ...
https://en.wikipedia.org/wiki/George_W._Rayfield
Adaptation (eye)Adaptation (eye)
Stuart JA, Brige RR (1996). "Characterization of the primary photochemical events in bacteriorhodopsin and rhodopsin". In Lee ...
https://en.wikipedia.org/wiki/Adaptation_(eye)
HalobacteriumHalobacterium
Their photosynthetic pigment, bacteriorhodopsin, is actually opaque to the longer-wavelength ultraviolet (its red color). In ... Bacteriorhodopsins isolated from Halobacterium salinarum have been especially studied for their applications in electronics and ... Particularly, bacteriorhodopsins have been used in holographic storage, optical switching, motion detection, and nanotechnology ... Halobacterium can be identified in bodies of water by the light-detecting pigment bacteriorhodopsin, which not only provides ...
https://en.wikipedia.org/wiki/Halobacterium
Shiladitya DasSarmaShiladitya DasSarma
"A transposable element from Halobacterium halobium which inactivates the bacteriorhodopsin gene". Proceedings of the National ...
https://en.wikipedia.org/wiki/Shiladitya_DasSarma
RCSB PDB - 6GA1: Bacteriorhodopsin, dark state, cell 1RCSB PDB - 6GA1: Bacteriorhodopsin, dark state, cell 1
Bacteriorhodopsin. A. 249. Halobacterium salinarum NRC-1. Mutation(s): 0 Gene Names: bop, VNG_1467G. Membrane Entity: Yes ... Bacteriorhodopsin (bR) is a light-driven proton pump. The primary photochemical event upon light absorption is isomerization of ... Bacteriorhodopsin (bR) is a light-driven proton pump. The primary photochemical event upon light absorption is isomerization of ... Three-dimensional view of ultrafast dynamics in photoexcited bacteriorhodopsin.. Nass Kovacs, G., Colletier, J.P., Grunbein, M. ...
https://www.rcsb.org/structure/6GA1
PRIMARY INTERMEDIATES IN THE PHOTOCHEMICAL CYCLE OF BACTERIORHODOPSIN. - Nokia Bell LabsPRIMARY INTERMEDIATES IN THE PHOTOCHEMICAL CYCLE OF BACTERIORHODOPSIN. - Nokia Bell Labs
Nokia sites use cookies to improve and personalize your experience and to display advertisements. The sites may also include cookies from third parties. By using this site, you consent to the use of cookies. Learn more ...
https://www.bell-labs.com/institute/publications/bl7891143/
Pages that link to Template:Bacteriorhodopsin/Metadata - CitizendiumPages that link to "Template:Bacteriorhodopsin/Metadata" - Citizendium
Template:Bacteriorhodopsin/Metadata (transclusion) ‎ (← links). View (previous 50 , next 50) (20 , 50 , 100 , 250 , 500) ... Bacteriorhodopsin/Related Articles (transclusion) ‎ (← links). *Microbial metabolism/Related Articles (transclusion) ‎ (← links ...
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High-yield production of bacteriorhodopsin via expression of a synthetic gene in Escherichia coliHigh-yield production of bacteriorhodopsin via expression of a synthetic gene in Escherichia coli
Structure-function studies on bacteriorhodopsin. III. Total synthesis of a gene for bacterio-opsin and its expression in ... Structure-function studies on bacteriorhodopsin. Total synthesis of a gene for bacterio-opsin and its expression in Escherichia ... Structure-function studies on bacteriorhodopsin. I. Expression of the bacterio-opsin gene in Escherichia coli. Journal of ... Structure-function studies on bacteriorhodopsin. II. Improved expression of the bacterio-opsin gene in Escherichia coli. ...
https://eurekamag.com/research/008/775/008775786.php
Bacteriorhodopsin mutants D85N, D85T and D85,96N as proton pumps :: MPG.PuReBacteriorhodopsin mutants D85N, D85T and D85,96N as proton pumps :: MPG.PuRe
Bacteriorhodopsin mutants D85N, D85T and D85,96N as proton pumps ... Bacteriorhodopsin mutants D85N, D85T and D85,96N as proton ... Tittor, J., Oesterhelt, D., & Bamberg, E. (1995). Bacteriorhodopsin mutants D85N, D85T and D85,96N as proton pumps. Biophysical ...
https://pure.mpg.de/pubman/faces/ViewItemFullPage.jsp?itemId=item_3284768_1&view=EXPORT
Immobilization of bacteriorhodopsin on synthetic membraneImmobilization of bacteriorhodopsin on synthetic membrane
V. Sediroğlu, "Immobilization of bacteriorhodopsin on synthetic membrane," Middle East Technical University, 1992. ...
https://open.metu.edu.tr/handle/11511/9691
An all-optical time-delay relay based on a bacteriorhodopsin film<...
An all-optical time-delay relay based on a bacteriorhodopsin film. Gui Ying Chen, Xu Xu Xu, Chun Ping Zhang, Shen Wen Qi, Qi ... Chen, GY, Xu, XX, Zhang, CP, Qi, SW & Song, QW 2008, An all-optical time-delay relay based on a bacteriorhodopsin film, ... An all-optical time-delay relay based on a bacteriorhodopsin film. / Chen, Gui Ying; Xu, Xu Xu; Zhang, Chun Ping et al. ... An all-optical time-delay relay based on a bacteriorhodopsin film. In: Chinese Physics B. 2008 ; Vol. 17, No. 11. pp. 4218-4225 ...
https://experts.syr.edu/en/publications/an-all-optical-time-delay-relay-based-on-a-bacteriorhodopsin-film
Direct and label-free determination of human glycated hemoglobin levels using bacteriorhodopsin as the biosensor transducer -...
Direct and label-free determination of human glycated hemoglobin levels using bacteriorhodopsin as the biosensor transducer. ... Direct and label-free determination of human glycated hemoglobin levels using bacteriorhodopsin as the biosensor transducer. ...
https://tmu.pure.elsevier.com/en/publications/direct-and-label-free-determination-of-human-glycated-hemoglobin-/fingerprints/?sortBy=alphabetically
Pages that link to Bacteriorhodopsin/Definition - CitizendiumPages that link to "Bacteriorhodopsin/Definition" - Citizendium
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Reversible photobleaching of bacteriorhodopsin molecules exposed to 570 mn laser light ePrints@IIScReversible photobleaching of bacteriorhodopsin molecules exposed to 570 mn laser light [email protected]
Hegde, Gopalkrishna M and Reddy, KPJ (2003) Reversible photobleaching of bacteriorhodopsin molecules exposed to 570 mn laser ... The phenomenon of reversible photobleaching in bacteriorhodopsin (BR) molecules exposed to 570 nm laser is presented. Creation ...
https://eprints.iisc.ac.in/17310/
Ultrafast spectroscopy of heme protein and bacteriorhodopsin - National Yang Ming Chiao Tung University Academic Hub
Ultrafast spectroscopy of heme protein and bacteriorhodopsin. *籔下, 篤史 (PI) ...
https://scholar.nycu.edu.tw/en/projects/ultrafast-spectroscopy-of-heme-protein-and-bacteriorhodopsin
DeCS 2016 - June 12, 2016 versionDeCS 2016 - June 12, 2016 version
Bacteriorhodopsin use Bacteriorhodopsins Bacteriorhodopsins Bacteriostat use Thiram Bacterium Host Interactions use Host ...
https://decs.bvs.br/I/DeCS2016_Alfab-B.htm
PDB 3HAO | Chain CRYSTAL STRUCTURE OF BACTERIORHODOPSIN MUTANT L94A CRYSTALLIZED FROM BICELLES | 3HAO A | 3D Structure | canSARSPDB 3HAO | Chain CRYSTAL STRUCTURE OF BACTERIORHODOPSIN MUTANT L94A CRYSTALLIZED FROM BICELLES | 3HAO A | 3D Structure | canSARS
CRYSTAL STRUCTURE OF BACTERIORHODOPSIN MUTANT L94A CRYSTALLIZED FROM BICELLES - 3HAO , canSARS ...
https://corona-1.cansar.icr.ac.uk/structure/3HAO/3d/3HAO_A
The site of attachment of retinal in bacteriorhodopsin. The epsilon-amino group in Lys-41 is not required for proton...The site of attachment of retinal in bacteriorhodopsin. The epsilon-amino group in Lys-41 is not required for proton...
... of bacteriorhodopsin have been shown previously to reassociate so as to regenerate the native bacteriorhodopsin chromophore in ... The site of attachment of retinal in bacteriorhodopsin. The epsilon-amino group in Lys-41 is not required for proton ... The site of attachment of retinal in bacteriorhodopsin. The epsilon-amino group in Lys-41 is not required for proton ... C-2 fragments were identical in their ability to reassociate with fragment C-1 and retinal to regenerate the bacteriorhodopsin ...
http://repository.ias.ac.in/15948/
Femtosecond-to-millisecond structural changes in a light-driven sodium pump | NatureFemtosecond-to-millisecond structural changes in a light-driven sodium pump | Nature
Bacteriorhodopsin: structural insights revealed using X-ray lasers and synchrotron radiation. Annu. Rev. Biochem. 88, 59-83 ( ... Retinal isomerization in bacteriorhodopsin captured by a femtosecond X-ray laser. Science 361, eaat0094 (2018). ... Three-dimensional view of ultrafast dynamics in photoexcited bacteriorhodopsin. Nat. Commun. 10, 3177 (2019). ... Proton uptake mechanism in bacteriorhodopsin captured by serial synchrotron crystallography. Science 365, 61-65 (2019). ...
https://www.nature.com/articles/s41586-020-2307-8?error=cookies_not_supported&code=1c1fa638-7d37-44c0-98be-4dcbd7a007bd
Copy this link to clipboardCopy this link to clipboard
... such as bacteriorhodopsin. Through special glasses, the molecule appears in its full three-dimensional glory as purple spirals ...
https://spectrum.ieee.org/the-beckman-institute-for-advanced-science-and-technology
Structural Biochemistry/Lipids - Wikibooks, open books for an open worldStructural Biochemistry/Lipids - Wikibooks, open books for an open world
Bacteriorhodopsin: is an integral protein found in photosynthesis bacterium. It is made up of three identical chains, hence, a ... Bacteriorhodopsin serves as a channel that can undergo conformational change to pump protons across the membrane (from cytosol ...
https://en.wikibooks.org/wiki/Structural_Biochemistry/Lipids
Fitxa persona
Bañó-Polo M; Martínez-Gil L; Barrera FN; Mingarro I. (2020) Insertion of Bacteriorhodopsin helix C into biological membranes. ...
https://www.uv.es/uvweb/universitat/ca/fitxa-persona-1285950309813.html?p2=mingarro
Search results for "Halobacteria" - microbewiki
font color=windowtext,Halobacteria only;,br /,,/font, ,font color=windowtext,bacteriorhodopsin ,/font, ...
https://microbewiki.kenyon.edu/index.php?title=Special:Search&profile=advanced&search=Halobacteria&fulltext=1
Jayant Kumar | Physics & Applied Physics | Kennedy College of Sciences | UMass Lowell
He, J.A., Samuelson, L., Li, L., Kumar, J., Tripathy, S.K. (1999). Bacteriorhodopsin thin film assemblies - immobilization, ... Second Harmonic Generation of Bacteriorhodopsin and its Application for Three-Dimensional Optical Memory", - Materials Research ...
https://www.uml.edu/Sciences/physics/faculty/kumar-jayant.aspx
Search results - ORA - Oxford University Research ArchiveSearch results - ORA - Oxford University Research Archive
Structural and orientational constraints of bacteriorhodopsin in purple membranes determined by oriented-sample solid-state NMR ... Functionally relevant coupled dynamic profile of bacteriorhodopsin and lipids in purple membranes. ...
https://ora.ox.ac.uk/?f%5Bf_contributors__name%5D%5B%5D=Kamihira%2C+M&per_page=100
PublikationenPublikationen
59) Two-Photon-Induced Selective Decarboxylation of Aspartic Acids D85 and D212 in Bacteriorhodopsin.. Imhof M, Rhinow D, Linne ...
https://www.uni-marburg.de/de/fb15/fachbereich/infrastruktur/servicelabors/massenspektrometrie-und-elementaranalytik/forschung
Gisela Brändén,Gisela Brändén,
Bacteriorhodopsin Karl Edman, Antoine Royant, Gisela Larsson, Frida Jacobson, Tom Taylor, David van der Spoel, Ehud Landau, Eva ...
https://www.gu.se/om-universitetet/hitta-person/giselabranden
Latest Licensable Biotechnology Inventions - BiotechblogLatest Licensable Biotechnology Inventions - Biotechblog
Bacteriorhodopsin fusion membrane protein expression system. Academia Sinica. Patent number: 9,067,985. Issue Date: June 30, ...
https://www.biotechblog.com/latest-licensable-biotechnology-inventions-14/
Molecular machines | Feature | Chemistry WorldMolecular machines | Feature | Chemistry World
Take bacteriorhodopsin, for example. It pumps protons across a cell membrane against a concentration gradient, and once inside ...
https://www.chemistryworld.com/features/molecular-machines/9457.article
Injector-based room-temperature serial crystallography of a membrane protein using synchrotron radiationInjector-based room-temperature serial crystallography of a membrane protein using synchrotron radiation
The bacteriorhodopsin microcrystals with sizes ranging from 5 to 40 µm traversed the beam at a speed of around 100 µm/s while ... Starting from 13000 hits (~ 1% hit rate) containing bacteriorhodopsin diffraction patterns, about 5700 frames could be indexed ... Crystals of the membrane protein bacteriorhodopsin, grown in lipidic cubic phase (LCP) to be delivered by a LCP-injector [1], ... diffraction pattern of bacteriorhodopsin with visible diffraction spots at up to 2.2 Å resolution. ...
https://esrf.fr/cms/live/live/en/sites/www/home/UsersAndScience/Publications/Highlights/highlights-2015/structural-biology/sb10.html
Channelrhodopsins of Volvox carteri are photochromic proteins that are specifically expressed in somatic cells under control of...
Structure of bacteriorhodopsin at 1.55 A resolution.. Luecke H, Schobert B, Richter HT, Cartailler JP, Lanyi JK., J. Mol. Biol. ... A pharaonis phoborhodopsin mutant with the same retinal binding site residues as in bacteriorhodopsin.. Shimono K, Furutani Y, ... Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy.. Henderson R, Baldwin JM, Ceska ... Two possible roles of bacteriorhodopsin; a comparative study of strains of Halobacterium halobium differing in pigmentation.. ...
https://pub.uni-bielefeld.de/record/2372803
Three-dimensional electron crystallography of protein microcrystals | eLifeThree-dimensional electron crystallography of protein microcrystals | eLife
1990) Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy J Mol Biol 213:899-929. ... 1996) Electron-crystallographic refinement of the structure of bacteriorhodopsin J Mol Biol 259:393-421. ... 1997) Surface of bacteriorhodopsin revealed by high-resolution electron crystallography Nature 389:206-211. ...
https://elifesciences.org/articles/01345
SpectroscopyProton pumpMutantsMembraneRetinalProteinFunctionalLightPurpleDynamicLaserStructureRhodopsinPhotocycleProteinsMembrane proteinChromophoreDynamicsKineticsPhotosynthesisVectorial proton translocationCytochrome oxidaseFourierSpectraPhospholipidProton releaseMutantPigmentsSimilarityRhodopsinsMoleculesLight-drivenStudiesCrystalsHigh-resolutionStructuresStructureWaterModelTransportEnergySingleSwitch
Spectroscopy2
  • Structural and orientational constraints of bacteriorhodopsin in purple membranes determined by oriented-sample solid-state NMR spectroscopy. (ox.ac.uk)
  • Le Coutre holds a Ph.D. in Biophysics for studying the reaction mechanism of the light-driven proton pump bacteriorhodopsin using time resolved Fourier Transform Infrared (FTIR) spectroscopy at the Max-Planck-Institute for Nutritional Physiology. (allamericanspeakers.com)
Proton pump2
  • Bacteriorhodopsin (bR) is a light-driven proton pump. (rcsb.org)
  • This sequence is similar to that of proton release and uptake observed for the light-activated proton pump bacteriorhodopsin. (uark.edu)
Mutants1
  • By replacing the corresponding residue to the primary proton acceptor in bacteriorhodopsin, fast-cycling ChR2 mutants (Cheta) have been created [16]. (hu-berlin.de)
Membrane3
  • Crystals of the membrane protein bacteriorhodopsin, grown in lipidic cubic phase (LCP) to be delivered by a LCP-injector [1] , were chosen as a test case for realistic applications. (esrf.fr)
  • The membrane develops under anaerobic conditions and is made almost entirely of the purple pigment BACTERIORHODOPSINS. (umassmed.edu)
  • Studying the dynamics of individual protein binding behavior, motor proteins and membrane trafficking in real-time, or visualizing the disruption of cellular junctions following antibody binding or structural changes as they occur in the native membrane protein bacteriorhodopsin is now possible with intuitive, easy-to-use techniques. (bruker.com)
Retinal2
  • The site of attachment of retinal in bacteriorhodopsin. (ias.ac.in)
  • The methylated and unmethylated C-2 fragments were identical in their ability to reassociate with fragment C-1 and retinal to regenerate the bacteriorhodopsin chromophore and to form functional proton-translocating vesicles. (ias.ac.in)
Protein1
  • Some of these concepts will be illustrated using the oxidative labeling of bacteriorhodopsin as an example, but numerous other labeling agents and protein systems are being highlighted as well. (uwo.ca)
Functional2
  • This material could be used for reconstitution of fully functional bacteriorhodopsin. (eurekamag.com)
  • Chymotryptic fragments C-1 (amino acids 72-248) and C-2 (amino acids 1-71) of bacteriorhodopsin have been shown previously to reassociate so as to regenerate the native bacteriorhodopsin chromophore in lipid/detergent mixtures and to form functional proton-translocating vesicles. (ias.ac.in)
Light3
  • Light-sensitive bacteriorhodopsin is combined with electronics to make the world's first bio-phototransceiver. (optics.org)
  • Bacteriorhodopsins function as an energy transducers, converting light energy into electrochemical energy via PROTON PUMPS . (bvsalud.org)
  • Reaction coupling, acceptor pK, and diffusion control in light induced proton release of bacteriorhodopsin. (mpg.de)
Purple1
  • Functionally relevant coupled dynamic profile of bacteriorhodopsin and lipids in purple membranes. (ox.ac.uk)
Dynamic1
  • Using a special property of dynamic complementary-suppression-modulated transmission (DCSMT) in the bacteriorhodopsin (bR) film, we have demonstrated an all-optical time-delay relay. (syr.edu)
Laser1
  • The phenomenon of reversible photobleaching in bacteriorhodopsin (BR) molecules exposed to 570 nm laser is presented. (iisc.ac.in)
Structure1
  • Starting from 13000 hits (~ 1% hit rate) containing bacteriorhodopsin diffraction patterns, about 5700 frames could be indexed, producing a data set which was subsequently used for structure solution to a resolution of 2.4 Å. (esrf.fr)
Rhodopsin10
  • How does bacteriorhodopsin differ from the rhodopsin present in mammalian eyes? (standardtoday.co.uk)
  • The key difference between them is that rhodopsin is a G-protein-coupled receptor, and this is not the case with bacteriorhodopsin. (standardtoday.co.uk)
  • however, the functions of rhodopsin and bacteriorhodopsin are different, and there is limited similarity in their amino acid sequences. (standardtoday.co.uk)
  • Both rhodopsin and bacteriorhodopsin belong to the 7TM receptor family of proteins, but rhodopsin is a G protein-coupled receptor and bacteriorhodopsin is not . (standardtoday.co.uk)
  • Microbial rhodopsins function as phototaxis receptors (sensory rhodopsin), light-driven proton or chloride ion transporters (bacteriorhodopsin and halorhodopsin) [2, 3, 5, 6, 8]. (standardtoday.co.uk)
  • Current models of GPCR structure are mainly derived from analogies with high-resolution structures of bacteriorhodopsin ( 7 ) and relatively low-resolution structures of rhodopsin ( 8 ). (aspetjournals.org)
  • Bacteriorhodopsin (bR) is a protein that realizes the simplest known form of biological photosynthetic energy storage, absorbing light and converting its energy into a proton gradient across the cellular membrane of archaebacteria through vectorial proton translocation [1] As its name indicates, bacteriorhodopsin is closely related to rhodopsin, the protein which acts as the primary light detector in the visual pathway of higher life forms [2-6]. (uiuc.edu)
  • Using high-resolution FTIR, we will study the conformational characteristics of bacteriorhodopsin and of rhodopsin in general and of the retinal environment in particular (including the photocycle intermediates L550 and M412 in bacteriorhodopsin and metarhodopsinII). (uab.cat)
  • The results suggest that seven and 12 transmembrane helix bundles resembling those observed experimentally (e.g., bacteriorhodopsin, rhodopsin and cytochrome c oxidase subunit I) may be generated by simulations using simple potentials. (ox.ac.uk)
  • Bacteriorhodopsin chimeras containing the third cytoplasmic loop of bovine rhodopsin activate transducin for GTP/GDP exchange. (wisc.edu)
Photocycle2
  • Pressure dependence of the photocycle kinetics of bacteriorhodopsin. (mpg.de)
  • In a collaborative study, Hendler and Levin have shown that lipids of the purple membrane of Halobacterium halobium directly influence the conformational structure of bacteriorhodopsin and control the kinetics, relaxation pathways, and regulation by actinic light of the photocycle intermediates of this integral membrane-protein proton pump. (nih.gov)
Proteins3
  • Although they are similar in both bacteriorhodopsins and rhodopsins being retinal-binding proteins , the similarity in their amino acid sequence is very limited. (standardtoday.co.uk)
  • In 1971 Walther Stoeckenius and Dieter Oesterhelt, both then at the University of California, San Francisco, discovered that one of these proteins, bacteriorhodopsin, acts as a single-component ion pump that can be briefly activated by photons of green light-a remarkable all-in-one molecular machine. (scientificamerican.com)
  • Proton-binding motifs of membrane-bound proteins: From bacteriorhodopsin to spike protein S. Front Chem, 9, 685761. (sfb1078.de)
Membrane protein4
  • The membrane protein bacteriorhodopsin (BR) can be kept soluble in its native state for months in the absence of detergent by amphipol (APol) A8-35, an amphiphilic polymer. (nih.gov)
  • Bacteriorhodopsin is a large membrane protein and a model for G-protein coupled receptors (GPCRs). (bl.uk)
  • Three differently labelled samples of bacteriorhodopsin were prepared to test the applicability of the various assignment strategies and the effects of deuteration on quality of solid state NMR spectra of a large, crystalline membrane protein. (bl.uk)
  • As a physicist by training, my professional life began with biophysical studies of an archaic form of photosynthesis as practiced by halophilic bacteria using the proton-pumping membrane protein bacteriorhodopsin. (mariobirkholz.de)
Chromophore1
  • Location and orientation of the chromophore in bacteriorhodopsin. (elsevier.com)
Dynamics3
  • This article demonstrates how molecular dynamics simulations can elucidate structure-function relationships in bacteriorhodopsin (bR) involving water molecules. (inria.fr)
  • In the present case, molecular dynamics (MD) studies are carried out on helix F model of bacteriorhodopsin (BR) Ace-(Ala)7-Trp-(Ala)2-Tyr-Pro-(Ala)2-Trp- (Ala)8-NHMe and compared with Ace-(Ala)7-Trp-(Ala)2-Tyr-(Ala)3-Trp-(Ala)8-NHMe in which the proline is replaced by alanine. (nih.gov)
  • Three-dimensional view of ultrafast dynamics in photoexcited bacteriorhodopsin. (mpg.de)
Kinetics2
  • To understand the specific, atomic-level, details of the electrogenic transport of protons across the membrane, our NHLBI collaborator uses spectrophotometry to study the rapid kinetics of the simple, photon-driven, proton pump bacteriorhodopsin (BR). (nih.gov)
  • Single molecule kinetics of bacteriorhodopsin by HS-AFM. (cornell.edu)
Photosynthesis2
  • According to NASA, the periodic color change is caused by micro algae producing carotenoids that help with photosynthesis and act as antioxidants and Halobacteriaceae , a bacteria in very salty water that releases "a red pigment called bacteriorhodopsin that absorbs light and converts it into energy for the bacteria. (boingboing.net)
  • Bacteriorhodopsin photosynthesis. (jku.at)
Vectorial proton translocation1
  • Finally, the charged groups of the salt bridge, repositioned by photoisomerization, provide a simple mechanism for vectorial proton translocation in bacteriorhodopsin. (elsevier.com)
Cytochrome oxidase2
  • Semenov, V. P. Skulachev Direct measurement of electric current generation by cytochrome oxidase, H+-ATPase and bacteriorhodopsin. (scholar.ru)
  • Primary attention has been on integral membrane, energy-transducing, proton pumps, namely cytochrome oxidase and bacteriorhodopsin (BR). (nih.gov)
Fourier1
  • Bacteriorhodopsin: fourier transform infrared methods for studies of protonation of carboxyl groups. (sigmaaldrich.com)
Spectra1
  • However, in applications of DNP to MAS spectra of biological systems, including studies of lysozyme, and bacteriorhodopsin, the enhancements have been smaller, e=40-50. (bridge12.com)
Phospholipid1
  • When reconstituted into phospholipid vesicles, bacteriorhodopsin from E. coli shows the expected proton pumping activity in response to illumination. (syr.edu)
Proton release1
  • Reaction coupling, acceptor pK, and diffusion control in light induced proton release of bacteriorhodopsin. (mpg.de)
Mutant1
  • R. Henderson (MRC) used electron microscopy, photolysis and freeze trapping to look at the structures of reaction intermediates in 2D crystals of wildtype and a mutant bacteriorhodopsin. (iucr.org)
Pigments1
  • A simple model for the early events in visual pigments and bacteriorhodopsin is proposed. (elsevier.com)
Similarity1
  • It shows 21% identity with and 38% similarity to bacteriorhodopsin (BR). (uni-goettingen.de)
Rhodopsins1
Molecules1
  • Furthermore, this molecular movie provides key insights into the role of active site water molecules and charged groups in dictating the overall vectorial nature of proton pumping by bacteriorhodopsin. (uiuc.edu)
Light-driven1
  • The absorbance changes that accompany the light-driven proton-pumping cycle of bacteriorhodopsin measured over a broad range of times, wavelengths, temperatures, and pH values have been globally fitted to the kinetic model K in equilibrium with L in equilibrium with X in equilibrium with M in equilibrium with N in equilibrium with O----bR. (nih.gov)
Studies2
  • Structure-function studies on bacteriorhodopsin. (syr.edu)
  • Dive into the research topics of 'Structure-function studies on bacteriorhodopsin. (syr.edu)
Crystals1
  • Utilization of lipidic cubic phases in the crystallization of bacteriorhodopsin (bR) has yielded long sought after crystals that diffract X-rays to 2 Å resolution. (elsevier.com)
High-resolution1
  • Surface of bacteriorhodopsin revealed by high-resolution electron crystallography. (expasy.org)
Structures1
  • It was observed that both bacteriorhodopsin-like and delta-endotoxin-like structures are generated in seven-helix bundle simulations, within which the composition varies dependent upon the cooling rate. (ox.ac.uk)
Structure1
  • Gouaux, E 1998, ' It's not just a phase: Crystallization and x-ray structure determination of bacteriorhodopsin in lipidic cubic phases ', Structure , vol. 6, no. 1, pp. 5-10. (elsevier.com)
Water1
  • In analysing bacteriorhodopsin, glucose was used to substitute for the water that is lost to the microscope vacuum. (cam.ac.uk)
Model1
  • The equilibrium side chain orientations of tryptophan and tyrosine residues are discussed and compared with those found in the recently proposed model of bacteriorhodopsin. (nih.gov)
Transport1
  • He defended his thesis about light induced proton transport of bacteriorhodopsin in April 1989. (mpg.de)
Energy1
  • Bacteriorhodopsins function as an energy transducers, converting light energy into electrochemical energy via PROTON PUMPS . (nih.gov)
Single2
  • Molecular Force Modulation Spectroscopy Revealing the Dynamic Response of Single Bacteriorhodopsins. (ist.ac.at)
  • Pulling single bacteriorhodopsin out of a membrane: Comparison of simulation and experiment. (bioexploratorium.pl)
Switch1
  • Using nonlinear photoinduced anisotropy in bacteriorhodopsin (bR) film, we presented and demonstrated an image switch in which the output can be tuned continuously by the intensity of a pumping beam. (syr.edu)
RCSB PDB - 6GA1: Bacteriorhodopsin, dark state, cell 1
RCSB PDB - 6GA1: Bacteriorhodopsin, dark state, cell 1 (rcsb.org)
Femtosecond-to-millisecond structural changes in a light-driven sodium pump | Nature
Femtosecond-to-millisecond structural changes in a light-driven sodium pump | Nature (nature.com)
Copy this link to clipboard
Copy this link to clipboard (spectrum.ieee.org)
Archaea - Wikipédia, a enciclopédia livre
Archaea - Wikipédia, a enciclopédia livre (pt.wikipedia.org)
Fitxa persona
Fitxa persona (uv.es)
Discovering and Differentiating New and Emerging Clonal Populations of Chlamydia trachomatis with a Novel Shotgun Cell Culture...
Discovering and Differentiating New and Emerging Clonal Populations of Chlamydia trachomatis with a Novel Shotgun Cell Culture... (wwwnc.cdc.gov)
Search results for Halobacteria - microbewiki
Search results for "Halobacteria" - microbewiki (microbewiki.kenyon.edu)
Deformation of helix C in the low-temperature L-intermediate of Bacteriorhodopsin
Deformation of helix C in the low-temperature L-intermediate of Bacteriorhodopsin (research.chalmers.se)
Find Research outputs - Experts@Syracuse
Find Research outputs - [email protected] (experts.syr.edu)
Molecular machines | Feature | Chemistry World
Molecular machines | Feature | Chemistry World (chemistryworld.com)
K P J Reddy - Google Scholar
K P J Reddy - Google Scholar (scholar.google.no)
Three-dimensional electron crystallography of protein microcrystals | eLife
Three-dimensional electron crystallography of protein microcrystals | eLife (elifesciences.org)
Find Research outputs - University of Illinois Urbana-Champaign
Find Research outputs - University of Illinois Urbana-Champaign (experts.illinois.edu)
De
De (lindau-nobel.org)
Photoinduced Processes in Nucleic Acids and Proteins: Faraday Discussion
Photoinduced Processes in Nucleic Acids and Proteins: Faraday Discussion (rsc.org)
Winter_2021_Bis2A_Facciotti_Reading_01 - Biology LibreTexts
Winter_2021_Bis2A_Facciotti_Reading_01 - Biology LibreTexts (bio.libretexts.org)
Sandwalk: Fun and games with Otangelo Grasso about photosynthesis
Sandwalk: Fun and games with Otangelo Grasso about photosynthesis (sandwalk.blogspot.com)
Intelligence in a Small Materials World | DEStech Publishing
Intelligence in a Small Materials World | DEStech Publishing (destechpub.com)
Publications | Max Planck Institute for the Structure and Dynamics of Matter
Publications | Max Planck Institute for the Structure and Dynamics of Matter (mpsd.mpg.de)
Book Johannes le Coutre | Speakers Bureau | Booking Agent Info
Book Johannes le Coutre | Speakers Bureau | Booking Agent Info (allamericanspeakers.com)
Structural organization of gap junction channels - Fingerprint - Scholars @ UT Health San Antonio
Structural organization of gap junction channels - Fingerprint - Scholars @ UT Health San Antonio (scholars.uthscsa.edu)
1at9.1 | SWISS-MODEL Template Library
1at9.1 | SWISS-MODEL Template Library (swissmodel.expasy.org)
Analog, digital, and opto-electronics circuitry | National Institute of Biomedical Imaging and Bioengineering
Analog, digital, and opto-electronics circuitry | National Institute of Biomedical Imaging and Bioengineering (nibib.nih.gov)
Computer-based instrumentation | National Institute of Biomedical Imaging and Bioengineering
Computer-based instrumentation | National Institute of Biomedical Imaging and Bioengineering (nibib.nih.gov)
Printed circuit board development | National Institute of Biomedical Imaging and Bioengineering
Printed circuit board development | National Institute of Biomedical Imaging and Bioengineering (nibib.nih.gov)
Optogenetics Scientists Take Lasker Prize for Basic Research
Optogenetics Scientists Take Lasker Prize for Basic Research (medscape.com)
Visible and IR Optical Scanning Spectrometry To Study Energy Transduction by Bacteriorhodopsin | National Institute of...
Visible and IR Optical Scanning Spectrometry To Study Energy Transduction by Bacteriorhodopsin | National Institute of... (nibib.nih.gov)
Isolation and Characterization of Halotolerant Bacteria Associated with the Midgut of Culex quinquefasciatus Say (Diptera:...
Isolation and Characterization of Halotolerant Bacteria Associated with the Midgut of Culex quinquefasciatus Say (Diptera:... (scialert.net)
Publications | Barbora Piknova, Ph.D. | NIDDK
Publications | Barbora Piknova, Ph.D. | NIDDK (niddk.nih.gov)
Laboratory of Chemical Physics - NIDDK
Laboratory of Chemical Physics - NIDDK (niddk.nih.gov)