Bacteriophage PRD1: Bacteriophage and type species in the genus Tectivirus, family TECTIVIRIDAE. They are specific for Gram-negative bacteria.Tectiviridae: A family of lipid-containing bacteriophages with double capsids which infect both gram-negative and gram-positive bacteria. It has one genus, Tectivirus.Bacteriophages: Viruses whose hosts are bacterial cells.Corticoviridae: A family of icosahedral, lipid-containing, non-enveloped bacteriophages containing one genus (Corticovirus).Bacteriophage T4: Virulent bacteriophage and type species of the genus T4-like phages, in the family MYOVIRIDAE. It infects E. coli and is the best known of the T-even phages. Its virion contains linear double-stranded DNA, terminally redundant and circularly permuted.Viral Proteins: Proteins found in any species of virus.DNA, Viral: Deoxyribonucleic acid that makes up the genetic material of viruses.Bacteriophage lambda: A temperate inducible phage and type species of the genus lambda-like viruses, in the family SIPHOVIRIDAE. Its natural host is E. coli K12. Its VIRION contains linear double-stranded DNA with single-stranded 12-base 5' sticky ends. The DNA circularizes on infection.Coliphages: Viruses whose host is Escherichia coli.Escherichia coli: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.Capsid Proteins: Proteins that form the CAPSID of VIRUSES.Capsid: The outer protein protective shell of a virus, which protects the viral nucleic acid.Bacteriophage T7: Virulent bacteriophage and type species of the genus T7-like phages, in the family PODOVIRIDAE, that infects E. coli. It consists of linear double-stranded DNA, terminally redundant, and non-permuted.Salmonella typhimurium: A serotype of Salmonella enterica that is a frequent agent of Salmonella gastroenteritis in humans. It also causes PARATYPHOID FEVER.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Lysogeny: The phenomenon by which a temperate phage incorporates itself into the DNA of a bacterial host, establishing a kind of symbiotic relation between PROPHAGE and bacterium which results in the perpetuation of the prophage in all the descendants of the bacterium. Upon induction (VIRUS ACTIVATION) by various agents, such as ultraviolet radiation, the phage is released, which then becomes virulent and lyses the bacterium.T-Phages: A series of 7 virulent phages which infect E. coli. The T-even phages T2, T4; (BACTERIOPHAGE T4), and T6, and the phage T5 are called "autonomously virulent" because they cause cessation of all bacterial metabolism on infection. Phages T1, T3; (BACTERIOPHAGE T3), and T7; (BACTERIOPHAGE T7) are called "dependent virulent" because they depend on continued bacterial metabolism during the lytic cycle. The T-even phages contain 5-hydroxymethylcytosine in place of ordinary cytosine in their DNA.Bacteriophage mu: A temperate coliphage, in the genus Mu-like viruses, family MYOVIRIDAE, composed of a linear, double-stranded molecule of DNA, which is able to insert itself randomly at any point on the host chromosome. It frequently causes a mutation by interrupting the continuity of the bacterial OPERON at the site of insertion.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Bacteriophage phi 6: Virulent bacteriophage and sole member of the genus Cystovirus that infects Pseudomonas species. The virion has a segmented genome consisting of three pieces of doubled-stranded DNA and also a unique lipid-containing envelope.Bacteriophage phi X 174: The type species of the genus MICROVIRUS. A prototype of the small virulent DNA coliphages, it is composed of a single strand of supercoiled circular DNA, which on infection, is converted to a double-stranded replicative form by a host enzyme.Bacteriophage P2: A species of temperate bacteriophage in the genus P2-like viruses, family MYOVIRIDAE, which infects E. coli. It consists of linear double-stranded DNA with 19-base sticky ends.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Adenoviruses, Human: Species of the genus MASTADENOVIRUS, causing a wide range of diseases in humans. Infections are mostly asymptomatic, but can be associated with diseases of the respiratory, ocular, and gastrointestinal systems. Serotypes (named with Arabic numbers) have been grouped into species designated Human adenovirus A-F.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.BooksCrystallography, X-Ray: The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Receptors, Virus: Specific molecular components of the cell capable of recognizing and interacting with a virus, and which, after binding it, are capable of generating some signal that initiates the chain of events leading to the biological response.DNA Replication: The process by which a DNA molecule is duplicated.Deoxyribonucleotides: A purine or pyrimidine base bonded to a DEOXYRIBOSE containing a bond to a phosphate group.Phenylglyoxal: A reagent that is highly selective for the modification of arginyl residues. It is used to selectively inhibit various enzymes and acts as an energy transfer inhibitor in photophosphorylation.Bacillus Phages: Viruses whose host is Bacillus. Frequently encountered Bacillus phages include bacteriophage phi 29 and bacteriophage phi 105.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Open Reading Frames: A sequence of successive nucleotide triplets that are read as CODONS specifying AMINO ACIDS and begin with an INITIATOR CODON and end with a stop codon (CODON, TERMINATOR).Chloroform: A commonly used laboratory solvent. It was previously used as an anesthetic, but was banned from use in the U.S. due to its suspected carcinogenicity.Culture Media: Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.Temperature: The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.Chrysophyta: A family of microscopic freshwater EUKARYOTA, commonly known as golden algae. They share many features with the BROWN ALGAE but are planktonic rather than benthic. Though most are photosynthetic, they are not considered truly autotrophic since they can become facultatively heterotrophic in the absence of adequate light. In this state they can feed on BACTERIA or DIATOMS.Bioreactors: Tools or devices for generating products using the synthetic or chemical conversion capacity of a biological system. They can be classical fermentors, cell culture perfusion systems, or enzyme bioreactors. For production of proteins or enzymes, recombinant microorganisms such as bacteria, mammalian cells, or insect or plant cells are usually chosen.Sodium Chloride: A ubiquitous sodium salt that is commonly used to season food.Agar: A complex sulfated polymer of galactose units, extracted from Gelidium cartilagineum, Gracilaria confervoides, and related red algae. It is used as a gel in the preparation of solid culture media for microorganisms, as a bulk laxative, in making emulsions, and as a supporting medium for immunodiffusion and immunoelectrophoresis.Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.MEDLINE: The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).Serial Publications: Publications in any medium issued in successive parts bearing numerical or chronological designations and intended to be continued indefinitely. (ALA Glossary of Library and Information Science, 1983, p203)Biological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.Salivary Gland Calculi: Calculi occurring in a salivary gland. Most salivary gland calculi occur in the submandibular gland, but can also occur in the parotid gland and in the sublingual and minor salivary glands.Molecular Biology: A discipline concerned with studying biological phenomena in terms of the chemical and physical interactions of molecules.Virion: The infective system of a virus, composed of the viral genome, a protein core, and a protein coat called a capsid, which may be naked or enclosed in a lipoprotein envelope called the peplos.Virus Assembly: The assembly of VIRAL STRUCTURAL PROTEINS and nucleic acid (VIRAL DNA or VIRAL RNA) to form a VIRUS PARTICLE.Virus Replication: The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.Bunyaviridae: A family of viruses, mainly arboviruses, consisting of a single strand of RNA. Virions are enveloped particles 90-120 nm diameter. The complete family contains over 300 members arranged in five genera: ORTHOBUNYAVIRUS; HANTAVIRUS; NAIROVIRUS; PHLEBOVIRUS; and TOSPOVIRUS.

Solution structure of bacteriophage PRD1 vertex complex. (1/32)

Bacteriophage PRD1 is a prototype of viruses with an internal membrane. The icosahedral capsid and major coat protein share structural similarity with the corresponding structures of adenovirus. The present study further explores similarities between these viruses, considering the 5-fold vertex assemblies. The vertex structure of bacteriophage PRD1 consists of proteins P2, P5, and P31. The vertex complex mediates host cell binding and controls double-stranded DNA delivery. Quaternary structures and interactions of purified spike proteins were studied by synchrotron radiation x-ray solution scattering. Low resolution models of the vertex proteins P5, P2, and P31 were reconstructed ab initio from the scattering data. Protein P5 is a long trimer that resembles the adenovirus spike protein pIV. The receptor-binding protein P2 is a 15.5-nm long, thin monomer and does not have an adenovirus counterpart. P31 forms a pentameric base with a maximum diameter of 8.5 nm, which is thinner than the adenovirus penton pIII. P5 further polymerize into a nonameric form ((P5(3))(3)). In the presence of P31, P5 associates into a P5(6):P31 complex. The constructed models of these assemblies provided support for a model of vertex assembly onto the virion. Although similar in overall architecture, clear differences between PRD1 and adenovirus spike assemblies have been revealed.  (+info)

Combined EM/X-ray imaging yields a quasi-atomic model of the adenovirus-related bacteriophage PRD1 and shows key capsid and membrane interactions. (2/32)

BACKGROUND: The dsDNA bacteriophage PRD1 has a membrane inside its icosahedral capsid. While its large size (66 MDa) hinders the study of the complete virion at atomic resolution, a 1.65-A crystallographic structure of its major coat protein, P3, is available. Cryo-electron microscopy (cryo-EM) and three-dimensional reconstruction have shown the capsid at 20-28 A resolution. Striking architectural similarities between PRD1 and the mammalian adenovirus indicate a common ancestor. RESULTS: The P3 atomic structure has been fitted into improved cryo-EM reconstructions for three types of PRD1 particles: the wild-type virion, a packaging mutant without DNA, and a P3-shell lacking the membrane and the vertices. Establishing the absolute EM scale was crucial for an accurate match. The resulting "quasi-atomic" models of the capsid define the residues involved in the major P3 interactions, within the quasi-equivalent interfaces and with the membrane, and show how these are altered upon DNA packaging. CONCLUSIONS: The new cryo-EM reconstructions reveal the structure of the PRD1 vertex and the concentric packing of DNA. The capsid is essentially unchanged upon DNA packaging, with alterations limited to those P3 residues involved in membrane contacts. These are restricted to a few of the N termini along the icosahedral edges in the empty particle; DNA packaging leads to a 4-fold increase in the number of contacts, including almost all copies of the N terminus and the loop between the two beta barrels. Analysis of the P3 residues in each quasi-equivalent interface suggests two sites for minor proteins in the capsid edges, analogous to those in adenovirus.  (+info)

The lytic enzyme of bacteriophage PRD1 is associated with the viral membrane. (3/32)

Bacteriophage PRD1 encodes two proteins (P7 and P15) that are associated with a muralytic activity. Protein P15 is a soluble beta-1,4-N-acetylmuramidase that causes phage-induced host cell lysis. We demonstrate here that P15 is also a structural component of the PRD1 virion and that it is connected to the phage membrane. Small viral membrane proteins P20 and P22 modulate incorporation of P15 into the virion and may connect it to the phage membrane. The principal muralytic protein involved in PRD1 DNA entry seems to be the putative lytic transglycosylase protein P7, as the absence of protein P15 did not delay initiation of phage DNA replication in the virus-host system used. The incorporation of two different lytic enzymes into virions may reflect the broad host range of bacteriophage PRD1.  (+info)

The small viral membrane-associated protein P32 is involved in bacteriophage PRD1 DNA entry. (4/32)

The lipid-containing bacteriophage PRD1 infects a variety of gram-negative cells by injecting its linear double-stranded DNA genome into the host cell cytoplasm, while the protein capsid is left outside. The virus membrane and several structural proteins are involved in phage DNA entry. In this work we identified a new infectivity protein of PRD1. Disruption of gene XXXII resulted in a mutant phenotype defective in phage reproduction. The absence of the protein P32 did not compromise the particle assembly but led to a defect in phage DNA injection. In P32-deficient particles the phage membrane is unable to undergo a structural transformation from a spherical to a tubular form. Since P32(-) particles are able to increase the permeability of the host cell envelope to a degree comparable to that found with wild-type particles, we suggest that the tail-tube formation is needed to eject the DNA from the phage particle rather than to reach the host cell interior.  (+info)

A direct transposon insertion tool for modification and functional analysis of viral genomes. (5/32)

Advances in DNA transposition technology have recently generated efficient tools for various types of functional genetic analyses. We demonstrate here the power of the bacteriophage Mu-derived in vitro DNA transposition system for modification and functional characterization of a complete bacterial virus genome. The linear double-stranded DNA genome of Escherichia coli bacteriophage PRD1 was studied by insertion mutagenesis with reporter mini-Mu transposons that were integrated in vitro into isolated genomic DNA. After introduction into bacterial cells by electroporation, recombinant transposon-containing virus clones were identified by autoradiography or visual blue-white screening employing alpha-complementation of E. coli beta-galactosidase. Additionally, a modified transposon with engineered NotI sites at both ends was used to introduce novel restriction sites into the phage genome. Analysis of the transposon integration sites in the genomes of viable recombinant phage generated a functional map, collectively indicating genes and genomic regions essential and nonessential for virus propagation. Moreover, promoterless transposons defined the direction of transcription within several insert-tolerant genomic regions. These strategies for the analysis of viral genomes are of a general nature and therefore may be applied to functional genomics studies in all prokaryotic and eukaryotic cell viruses.  (+info)

The receptor binding protein P2 of PRD1, a virus targeting antibiotic-resistant bacteria, has a novel fold suggesting multiple functions. (6/32)

Bacteriophage PRD1 is unusual, with an internal lipid membrane, but has striking resemblances to adenovirus that include receptor binding spikes. The PRD1 vertex complex contains P2, a 590 residue monomer that binds to receptors on antibiotic-resistant strains of E. coli and so is the functional counterpart to adenovirus fiber. P2 structures from two crystal forms, at 2.2 and 2.4 A resolution, reveal an elongated club-shaped molecule with a novel beta propeller "head" showing pseudo-6-fold symmetry. An extended loop with another novel fold forms a long "tail" containing a protruding proline-rich "fin." The head and fin structures are well suited to recognition and attachment, and the tail is likely to trigger the processes of vertex disassembly, membrane tube formation, and subsequent DNA injection.  (+info)

The unique vertex of bacterial virus PRD1 is connected to the viral internal membrane. (7/32)

Icosahedral double-stranded DNA (dsDNA) bacterial viruses are known to package their genomes into preformed procapsids via a unique portal vertex. Bacteriophage PRD1 differs from the more commonly known icosahedral dsDNA phages in that it contains an internal lipid membrane. The packaging of PRD1 is known to proceed via preformed empty capsids. Now, a unique vertex has been shown to exist in PRD1. We show in this study that this unique vertex extends to the virus internal membrane via two integral membrane proteins, P20 and P22. These small membrane proteins are necessary for the binding of the putative packaging ATPase P9, via another capsid protein, P6, to the virus particle.  (+info)

Probing the ability of the coat and vertex protein of the membrane-containing bacteriophage PRD1 to display a meningococcal epitope. (8/32)

Bacteriophage PRD1 is an icosahedral dsDNA virus with a diameter of 740 A and an outer protein shell composed of 720 copies of major coat protein P3. Spike complexes at the vertices are composed of a pentameric base (protein P31) and a spike structure (proteins P5 and P2) where the N-terminal region of the trimeric P5 is associated with the base and the C-terminal region of P5 is associated with receptor-binding protein P2. The functionality of proteins P3 and P5 was investigated using insertions and deletions. It was observed that P3 did not tolerate changes whereas P5 tolerated changes much more freely. These properties support the hypothesis that viruses have core structures and functions, which remain stable over time, as well as other elements, responsible for host interactions, which are evolutionally more fluid. The insertional probe used was the apex of exposed loop 4 of group B meningococcal outer membrane protein PorA, a medically important subunit vaccine candidate. It was demonstrated that the epitope could be displayed on the virus surface as part of spike protein P5.  (+info)

A cell-free system has been developed from cells of an Escherichia coli strain, carrying cloned genes 1 (DNA polymerase) and 8 (terminal protein) of bacteriophage PRD1, that catalyzes protein-primed DNA synthesis. DNA synthesis in vitro is entirely dependent upon the addition of PRD1 DNA-terminal protein complex as template, Mg²⁺, and four deoxyribonucleoside triphosphates. The origin and direction of PRD1 DNA replication in vitro were determined by restriction enzyme analysis of ³²P-labeled PRD1 DNA synthesized in this system. Replication starts at either end of the linear PRD1 DNA template. Analysis by alkaline sucrose gradient centrifugation and alkaline agarose gel electrophoresis of DNA synthesized in vitro showed that full-length PRD1 DNA is synthesized. DNA elongation in this system is inhibited by the drug aphidicolin. On the other hand, DNA initiation is inhibited by phenylglyoxal, an arginine-specific α-dicarbonyl reagent. In vitro studies have also demonstrated that linear ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Capsid protein that self-associates to form 11 pentons, building the T=13 laevo capsid in association with 160 hexamers of gp23* and one dodecamer of gp20.
1N7U: The Receptor Binding Protein P2 of PRD1, a Virus Targeting Antibiotic-Resistant Bacteria, Has a Novel Fold Suggesting Multiple Functions.
Virus particles Monoliths Ion exchang echromatography Virus purification Bacteriophage PRD1 Bacteriophage phi05_2302
i.e. production rate, and observe the changes in Moreover, his work leaves open the questions of what causes the variation and whether it is evolutionarily significant. My work follows up on Delbrucks, except that I chose to look at a different, but closely related life history trait, lysis time. Earlier work has shown that there is a direct correlation between lysis time and burst size: the longer the phage waits to lyse the cell, the more babies it can produce. So it makes a good proxy for burst size, as well as an interesting life history trait in its own right. Plus, we now have the genetic techniques to manipulate the phages genome and dissect the causes of variation: to wit, the ability to manipulate the holin protein structure and to alter the strength of the promoter that controls holin production. All we need is a way of observing lysis time for individual cells. Enter the microscope-mounted perfusion chamber! Here is the setup ...
PRD is a medicine available in a number of countries worldwide. A list of US medications equivalent to PRD is available on the Drugs.com website.
Effect of correction on averaged PRD1 sub-tomograms. (A) Fourier shell correlation between averaged maps obtained from aligned sub-tomograms split in two datase
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Backing up a step though, if youre trying to throw away whole triangles whose vertices have some color that matches a shader-determined criteria, then it would be much more efficient to kill the triangle in the vertex shader rather than in every single fragment (pixel or sample) generated by the triangle. Theres no discard in the vertex shader, but you can mimic this by just moving each vertex behind the near clip plane. If youre using a perspective projection, heres one way to do that ...
Vertex Pharmaceuticals Incorporated (NASDAQ:VRTX) reported consolidated financial results for the quarter ended March 31, 2017. Vertex also reiterated guid
Accounting Consultancy Pte Ltd is located at Vertex, 33 Ubi Avenue 3, Tel 8616 8610, view Accounting Consultancy Pte Ltd location, products and services on Streetdirectory Map
A^{(2)}_{2n},A^{(2)}_{2n-1},B^{(1)}_n,C^{(1)}_n,D^{(1)}_{n}$ Lie algebras. By the method, we solve these models with the trivial K matrix and find that our results agree with that obtained by analytical ...
stipuliform lithographer Lithosiidae nonhousekeeping clinkery polyoxide vertices Amphrysian henhouse colberter hambergite unmaintained exterritorial pinned reversedly selectionism ungraveled bardash Linguata uncompromisingly crood witheredly alban aryballus cleeky [email protected] ...
The present invention relates to a Gram-negative glycosaminoglycan gene and methods of making and using same. The present invention relates to recombinant Gram-positive host cells containing a Gram-ne
Human adenoviruses (HAdVs) are nonenveloped proteinaceous particles containing a linear double-stranded DNA genome. HAdVs cause a spectrum of pathologies in all populations regardless of health standards. Following repeat exposure to multiple HAdV types, we develop robust and long-lived humoral and cellular immune responses that provide life-long protection from de novo infections and persistent HAdV. How HAdVs, anti-HAdV antibodies and antigen presenting cells (APCs) interact to influence infection is still incompletely understood. In our study, we used physical, pharmacological, biochemical, fluorescence and electron microscopy, molecular and cell biology approaches to dissect the impact of immune-complexed HAdV (IC-HAdV) on human monocyte-derived dendritic cells (MoDCs). We show that IC-HAdV generate stabilized complexes of ~200 nm that are efficiently internalized by, and aggregate in, MoDCs. By comparing IC-HAdV, IC-empty capsid, IC-Ad2ts1 (a HAdV-C2 impaired in endosomal escape due to a ...
Epstein-Barr virus (EBV) is a human herpesvirus with a linear double-stranded DNA genome that is carried asymptomatically by most people. Symptomless primary infection is usual in childhood, establishing a lifelong carrier state where the virus persists as a latent infection of circulating B cells. The virus replicates recurrently in oropharyngeal epithelial cells, with consequent shedding of virus in saliva transmitting infection....
To diagnose PRD, the veterinary ophthalmologist examines the retina with an instrument called an indirect ophthalmoscope. Changes in the retinal blood vessel pattern, the optic nerve head and the reflective substance within the dogs eye (called the tapetum) are classic signs of PRD.. However, PRD will progress at different rates in different breeds. In some breeds PRD causes little or no early changes, and the eyes of these dogs may appear normal until they are in the later stages of the disease. This variation makes it difficult for the vet to determine just how long any particular dog will continue seeing.. There is no possible treatment for PRD, although a number of vitamin therapies have been suggested. At this time, none of the vitamin treatments have been scientifically proven to be effective, so use of vitamins must be deemed a naturopathic remedy rather than a medical treatment.. Cataracts may occur in some patients with PRD, and generally occur later in the disease. Formation of ...
Advanced specialist practitioner in the late effects of pelvic radiation Liz Walne, who is leading on the project, explained: "While radiotherapy is becoming increasingly effective as a treatment, for some patients, being cured of cancer can come at a sacrifice to their quality of life.. "For too long, both patients and clinicians have accepted the symptoms of PRD as a trade-off As a result, symptoms are under reported, not properly assessed and mismanaged.". Liz continued: "Through our pilot specialist service, our aim is to identify and treat PRD to resolve or improve symptoms and thereby improve quality of life. We want the project to provide a foundation on which to develop a business case for permanent funding for the service, including all relevant trusts, once a better understanding of it is achieved.". Dan Hill, Rosemere Cancer Foundations chief officer, said: "We are proud to support such an important pilot project that is raising awareness of and seeking to treat PRD, a condition that ...
b) The classical abhidhammic theory of matter primarily deals with 28 supposed elemental qualities which are never found alone, but are always combined in or associated with quasi-atomic particles called "rūpakalāpas." The naïve realism underlying this philosophy is manifest, and furthermore has been scientifically obsolete for centuries. As an example the four ("ultimately real") secondary material qualities supposedly present in all rūpakalāpas-color, odor, flavor, and nutritional essence-will be very briefly considered. The formulators of the theory evidently did not perceive that color, as such, exists only in the mind and is merely a symbolic interpretation of a certain bandwidth of electromagnetic radiation; and that furthermore the hypothetical rūpakalāpa is much smaller than the smallest wavelength of visible light. An individual rūpakalāpa, unless, perhaps, it could somehow be identified with a photon, could be endowed with color only potentially and even then in a very ...
vertex and segment objects used by polygon. vertex.php This package can be used to perform different types of geometric operations with polygons. It provides generic polygon and vertex classes that support mixing lines and arc segments between vertices. Polygons may be self-intersecting. It provides means to perform boolean operations AND and OR (Intersect and Union) with the shapes and...
The UC College of Medicine is continuing its upward path in cutting-edge research to enhance discovery sciences and facilitate translation of these discoveries to improve health and clinical care while recruiting new faculty. The new undergraduate program fosters scientific curiosity and investigation for our students. We are creating an environment of advanced clinical care that surpasses any in the region.. ...
A graph is called cubic if three edges meet at each vertex. Simple graphs permit only a single edge to link two distinct vertices, multigraphs allow more than one edge to link two distinct vertices, pseudographs also allow a vertex to link to itself (i.e., form a self-loop.) A graph is an abstraction: a set of symmetrical relations (edges) between pairs of members of a set (the set of vertices). For example, the friendships (edges) between persons (vertices) listed in a phonebook. Such an abstraction has no geometry until we make some decisions not specified in the graph itself in order to place (embed) its vertices and edges in 3D space, or on the Euclidean plane, or on some other surface or in some other space. Sometimes a given graph can be embedded in a space in fundamentally different ways, e.g., a left-handed and a right-handed version. The embedding, not the graph itself, is our guide to these important practical details. See Topics in Trivalent Graphs by Marijke van Gans for a clear ...
Vertex Pharmaceuticals Incorporated (NASDAQ:VRTX) weekly options are pricing in a move of +/- $10 with Implied VOL currently in the 28th percentile over th
BOSTON--(BUSINESS WIRE)-- Vertex Pharmaceuticals Incorporated (Nasdaq: VRTX) today announced the planned initiation of two Phase 2 studies to evaluate the ...
Predicted price for today: 156.08 Accuracy and performance of Vertex Pharmaceuticals Incorporated (VRTX) stock prediction using Deep Learning.
Vertex Pharmaceuticals said it would seek regulatory approval later this year for an experimental cystic-fibrosis drug that helped produce a statistically significant improvement in patients lung function compared with placebo in two late-stage studies.
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ENGLISH ABSTRACT: The domination number of a graph is the cardinality of a smallest subset of its vertex set with the property that each vertex of the graph is in the subset or adjacent to a vertex in the subset. This ...
1. 20x=y2 2. (x-3)squared =1/2(y+1) 3. y2+14y+4x+45=0 Find an equation of the parabola that satisfies the given conditions Focus F(0-4), directrix y=4 Find the vertices, the foci and the equations of the asymptotes.
Holin se v organizmu presnovi zlasti do trimetilamina, ki ima vonj po ribah. Velika količina zaužitega holina lahko zato povzroči neprijeten telesni vonj. Pri določeni genetski motnji, trimetilaminuriji, bolniki niso zmožni nadalje razgraditi trimetilamina in posledica je močan telesni vonj po ribah. Pri ublažitvi telesnega vonja pomaga dieta, ki vsebuje čim manj holina.. ...
The motivation for focusing on a specific virus is often its importance in terms of impact on human interests. The chlorella viruses are a notable exception and 40 years of research has made them the undisputed model system for large icosahedral dsDNA viruses infecting eukaryotes. Their status has changed from inconspicuous and rather odd with no ecological relevance to being the Phycodnaviridae type strain possibly affecting humans and human cognitive functioning in ways that remain to be understood. The Van Etten legacy is the backbone for research on Phycodnaviridae. After highlighting some of the peculiarities of chlorella viruses, we point to some issues and questions related to the viruses we choose for our research, our prejudices, what we are still missing, and what we should be looking for.
Titering of Bacterial Viruses Related protocols: Preparation of Phage Stocks Commonly Used Media for Phage Growth Agar Overlay Technique When an individual bacterial virus grows in a bacterial host suspended in a top agar lawn, its progeny infect and lyse the surrounding host cells. This causes the appearance of a hole or plaque in…
DNA transport in Streptococcus pneumoniaewas studied using donor molecules labelled either at the 3′ or at the 5′ end, on one strand only. In contrast to 5′ end label, 3′ end label was not taken up...
The efficacy of PRD125 in blunting the continual expansion of the intestinal and hepatic pools of EC in Lal−/− mice is best illustrated by comparing the data for the treated mutants with those previously reported for Lal−/−:Soat2−/− mice (Lopez et al., 2014). In those studies, the hepatic EC concentrations in the Lal−/−:Soat2−/− mice versus their Lal−/−:Soat2+/+ littermates, all at 52 days of age, were 15.2 versus 54.3 mg/g, respectively. The corresponding values for LAL mutants given PRD125 versus their untreated Lal−/− mice controls were 23.4 and 56.5 mg/g, respectively (Fig. 3C). In the Lal−/− mice given PRD125, liver mass was 28% less than that in the untreated Lal−/− mice (Fig. 3A). This marked contraction in liver weight was comparable to that manifested in the Lal−/−:Soat2−/− mice (34%) (Lopez et al., 2014). From these sets of data, it can be calculated that the percentage reduction in whole liver cholesterol content (mg/organ) in the ...
GRAPH vertices="5" edges="5", ,VERTEX id="1", ,COORDINATE, 1 1 ,/COORDINATE, ,/VERTEX, ,VERTEX id="2", ,COORDINATE, 2 1 ,/COORDINATE, ,/VERTEX, ,VERTEX id="3", ,COORDINATE, 3 1 ,/COORDINATE, ,/VERTEX, ,VERTEX id="4", ,COORDINATE, 1 2 ,/COORDINATE, ,/VERTEX, ,VERTEX id="5", ,COORDINATE, 2 2 ,/COORDINATE, ,/VERTEX, ,EDGE source="1" target="2"/, ,EDGE source="2" target="3"/, ,EDGE source="1" target="4"/, ,EDGE source="2" target="5"/, ,EDGE source="2" target="3"/, ,/GRAPH ...
The Pax3/7 genes, also known as Pax group III, encode proteins with a PRD domain and a complete PRD-type homeodomain. There are two genes in human, one in amphioxus and three in Drosophila (prd, gsb, gsbn ...
Holin je u vodi rastvoran esencijalni nutrijent.[4][5][6][7] On se obično svrstava u B-kompleks vitamina. Holin se normalno javlja u obliku raznih kvaternarnih amonijum soli koje sadrže N,N,N-trimetiletanolamonijum katjon.. Katjon holina se javlja kao čeona grupa fosfatidilholina i sfingomijelina, dve klase fosfolipida koje su široko rasprostranjene u ćelijskim membranama. Holin je prekursorni molekul za neurotransmiter acetilholin koji ima veliki broj funkcija, kao što su memorija i kontrola mišića.. Holin se mora uneti putem hrane da bi telo ostalo zdravo.[8] On se koristi u sintezi gradivnih komponenti ćelijskih membrana.[9]. ...
Hi there, right now Im in the middle of translating a shader from GPU assembler to glsl. Ive just started with glsl a week ago, and all the stuff Ive read about it is this article Article At NeHe\s and some of the links provided there, so please dont flame too hard if this is just some simple thing Im over looking :) Its a vertex shader for bone animation, 4 bones per vertex. In the assebler version it indexes the required matrix for the transformations like so: ATTRIB index =
Happier news greeted shareholders of Vertex Pharmaceuticals this morning, after data from "an ongoing Phase 2 study of VX-809 and KALYDECO ... showed significant improvements in lung function ... among adults with cystic fibrosis." This "statistically significant" clinical data promoted two analysts, ISI Group and JMP Securities, to up their ratings on Vertex to buy.. ISI crunched the numbers and concluded Vertex is worth $68 a share. JMP jumped even farther ahead and set a new price target of $100. Whichever number you believe, both analysts are looking smart this morning, as the shares leaped nearly 50% in response to the news (and the buy ratings). But are there any more gains in store?. Perhaps. You see, even at 39 times earnings, Vertex doesnt look that expensive relative to Street expectations for the company. On average, analysts see this company growing earnings at upward of 50% per year over the next five years. Thats more than fast enough to justify the P/E if Vertex can hit the ...
Hi I have currently used a vertex buffer to render one quad using 4 vertices and a triangle strip using using memcpy(vtxQuad, vtx, sizeof(vtx) ); Where vtx i...
I am learning how to use Vertex and Index buffers with shaders. I am still very new the concept and I am working on a big project course atm.Basically I...
Let G=(V,E) be a graph with vertex set V and edge set E. A vertex v∈Vve-dominates every edge incident to it as well as every edge adjacent to these incident ...
If the MoveTo row is the first row in the section, the Y cell represents the y-coordinate of the first vertex of a path. If the MoveTo row appears between two rows, the Y cell represents the y-coordinate of the first vertex after the break in the path. ...
Hi All,I recently picked up an OCZ Agility 4 SSD, 256 GB. My current setup has a 1TB HDD and a 90GB vertex 2. The OS is on the vertex 2 as well as a game I play frequently. The 1TB HDD has random othe...
Im sure the intentions of whoever wrote the press release were good . . . but . . . it is quite a stretch. Still, interesting that it made it into Google News. The research the author discusses has nothing to do with Crossfit. The press release does, however, attempt to associate a high-fat diet (promoted by some Crossfitters as healthy than other diets) with lower incidence of cardiovascular disease by comparing incidence of disease between residents of Switzerland and Australian aboriginals living in modern Australia. The claim was that a high-fat dining Swiss have less cardiovascular disease than the presumed low-fat dining Australian Aboriginals and that, therefore, high-fat diets are healthier than low-fat diets.. I have not looked up the statistics for the Swiss, but Australian Aboriginals have been suffering increasing rates of cardiovascular disease over at least the last 30 years. Few modern Aboriginals are likely to be following a traditional Aboriginal diet. It is extremely unlikely ...
In a line graph L(G), each vertex of degree k in the original graph G creates k(k-1)/2 edges in the line graph. For many types of analysis this means high-degree nodes in G are over-represented in the line graph L(G). For instance, consider a random walk on the vertices of the original graph G. This will pass along some edge e with some frequency f. On the other hand, this edge e is mapped to a unique vertex, say v, in the line graph L(G). If we now perform the same type of random walk on the vertices of the line graph, the frequency with which v is visited can be completely different from f. If our edge e in G was connected to nodes of degree O(k), it will be traversed O(k2) more frequently in the line graph L(G). Put another way, the Whitney graph isomorphism theorem guarantees that the line graph almost always encodes the topology of the original graph G faithfully but it does not guarantee that dynamics on these two graphs have a simple relationship. One solution is to construct a weighted ...
At PRD Tech, we are committed to be the technology leaders in promoting a cleaner environment, by providing innovative solutions to the industries that are meaningful, cheaper, smarter, cost effective, and technologically feasible. Our main goal is to enable the ease of implementation of environmental control technologies, that will also allow the industries maintain their profitable operations.
Sergey Edunov created GIRAPH-1100: ------------------------------------- Summary: Multiple mutation requests to one vertex result in failure Key: GIRAPH-1100 URL: https://issues.apache.org/jira/browse/GIRAPH-1100 Project: Giraph Issue Type: Bug Reporter: Sergey Edunov Assignee: Sergey Edunov The scenario is simple: You send multiple addEdgeRequest() where the source vertex of new edge does not exist (typical scenario for adding reverse edges). If two of these requests happen to arrive in the single SendPartitionMutationsRequest, giraph is unable to handle it: FATAL 2016-07-26 17:59:09,563 [netty-server-worker-6] org.apache.giraph.graph.GraphTaskManager - uncaughtException: OverrideExceptionHandler on thread netty-server-worker-6, msg = readFields: Already has vertex id 977939745592684, exiting... java.lang.IllegalStateException: readFields: Already has vertex id 977939745592684 at ...
p>An evidence describes the source of an annotation, e.g. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc.,/p> ,p>,a href="/manual/evidences">More…,/a>,/p> ...
We show that the shadow vertex simplex algorithm can be used to solve linear programs in strongly polynomial time with respect to the number n of variables, the number m of constraints, and 1/\delta, where \delta is a parameter that measures the flatness of the vertices of the polyhedron. This extends our recent result that the shadow vertex algorithm finds paths of polynomial length (w.r.t. n, m, and 1/delta) between two given vertices of a polyhedron [4]. Our result also complements a recent result due to Eisenbrand and Vempala [6] who have shown that a certain version of the random edge pivot rule solves linear programs with a running time that is strongly polynomial in the number of variables n and 1/\delta, but independent of the number m of constraints. Even though the running time of our algorithm depends on m, it is significantly faster for the important special case of totally unimodular linear programs, for which 1/delta\le n and which have only O(n^2) constraints ...
The Division of Cardiovascular Health and Disease is recognized for its long-standing commitment to patient care, education and research.
The UC College of Medicine is continuing its upward path in cutting-edge research to enhance discovery sciences and facilitate translation of these discoveries to improve health and clinical care while recruiting new faculty. The new undergraduate program fosters scientific curiosity and investigation for our students. We are creating an environment of advanced clinical care that surpasses any in the region.. ...
The UC College of Medicine is continuing its upward path in cutting-edge research to enhance discovery sciences and facilitate translation of these discoveries to improve health and clinical care while recruiting new faculty. The new undergraduate program fosters scientific curiosity and investigation for our students. We are creating an environment of advanced clinical care that surpasses any in the region.. ...
The UC College of Medicine is continuing its upward path in cutting-edge research to enhance discovery sciences and facilitate translation of these discoveries to improve health and clinical care while recruiting new faculty. The new undergraduate program fosters scientific curiosity and investigation for our students. We are creating an environment of advanced clinical care that surpasses any in the region.. ...
Suhail Masadeh, DPM is a member of the University of Cincinnati College of Medicine and Associate Professor of Surgery; Director, Division of Podiatric Medicine & Surgery
Working model of vertex ring assembly. See text for details. Solid black arrows indicate a strict hierarchical requirement for vertex enrichment. Dotted arrows
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Not to take the spotlight from Warren Marshall (and Kenneth Hurley), but I felt it may be interesting to provide another Vertex Buffer implementation for discussion. I use the following implementation as a simple interface for accessing vertex buffers. The objective was to create an easy to use interface that I could code against regardless if I use OpenGL or DirectX. Although I only provide the Direct X implementation, the OpenGL uses vertex arrays... I opted not to provide the OpenGL implementation due to the previous COTD regarding Direct X. The code submitted is free to use as you please. However I request that you check the D3D implementation and modify it as needed. It is basic and does the job for my needs. I do not claim that this is the most efficient code or most elegant way to solve the problem. Id quickly like to thank ALL of the people who have submitted COTD entries. A lot of them have proven to be useful, regardless if they had been flawed or not. There are many times someone ...
We have been intrigued by the parallels between PRD1 and adenovirus since we discovered striking similarities in their overall structure in earlier studies," says structural biologist Roger M. Burnett, Ph.D., a professor at The Wistar Institute and senior author on the Nature Structural Biology study. "Our results reveal that PRD1 also has similarities to simpler viruses and reinforce the idea that there is a continuum of viral architectures running through viruses that infect such different hosts as bacteria, plants, and animals, including humans. An appreciation of these parallels is important, as findings in one viral system may provide valuable insights into another. We have also learned more about membranes, which are very hard to study with conventional techniques, and see now how they can be involved in packaging viral DNA ...
Vertex Pharmaceuticals Incorporated (VRTX) today announced an access agreement with NHS England for all currently licensed Vertex cystic fibrosis (CF) medicines and any future indications of these medicines. This means that within 30 days patients with CF in England ages 2 years and older who have two
Vertex Pharmaceuticals wowed the cystic fibrosis community earlier this year with its new drug that improves lung function for patients with a rare form
We initiate the first systematic study of the NP-hard Cluster Vertex Deletion (CVD) problem (unweighted and weighted) in terms of fixed-parameter algorithmics. In the unweighted case, one searches for
Role of chronic stress and depression in periodontal diseases (pages 127-138). Kimberly R. Warren, Teodor T. Postolache, Maureen E. Groer, Omar Pinjari, Deanna L. Kelly and Mark A. Reynolds. Version of Record online: 9 DEC 2013 , DOI: 10.1111/prd.12036. ...
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This course allowed me indeed to think of math as a useful tool because there were many concepts I hardly knew or didnt know at all and now I am able to apply them easily. For example I did not really know how to compute a vertexs coordonates, or how to establish if a quadratic function has a ...
Press Release Marketing will give you the best bang for the buck. Many a struggling business has been saved by sending out PRs to stimulate business. All of our News Channels are Bona-Fide News Sites, and will give your SEO a boost.. A Press Release should be written by a professional, Once it is released, it goes viral, so you want to have the best Press Release possible. Our PR Distribution Package includes writing the PR, unlike other News Sites that do not include the writing.. For PR Premo Package Info: http://prdpressreleasedistribution.com/. ...
Press Release Marketing will give you the best bang for the buck. Many a struggling business has been saved by sending out PRs to stimulate business. All of our News Channels are Bona-Fide News Sites, and will give your SEO a boost.. A Press Release should be written by a professional, Once it is released, it goes viral, so you want to have the best Press Release possible. Our PR Distribution Package includes writing the PR, unlike other News Sites that do not include the writing.. For PR Premo Package Info: http://prdpressreleasedistribution.com/. ...
Some notes on the Sugihara&Iri 1994 topology-based algorithm for incremental construction of the voronoi diagram for point sites.. (A) We start with initial VD for point sites that have already been inserted. We want to insert a new site, shown as a yellow sphere.. (B) We then find the VD face to which the new vertex belongs. Among the vertices that bound this face we search for a seed-vertex, shown in pink. This is the vertex that is closest to the new generator.. (C) From the seed vertex, we search for more vertices that should be deleted(red). The vertices should form a tree (a connected, acyclic graph). Vertices that are closer to the new site than to any other site should be deleted. However due to floating-point errors its not possible to blindly rely on an inCircle() predicate for finding the delete-tree. Its necessary to also enforce the correct topology, namely (i) the delete-vertices should form a tree, and (ii) for any incident face, the delete-vertices are connected. This ensures ...
A perfect elimination ordering in a graph is an ordering of the vertices of the graph such that, for each vertex v, v and the neighbors of v that occur after v in the order form a clique. A graph is chordal if and only if it has a perfect elimination ordering.[3] Rose, Lueker & Tarjan (1976) (see also Habib et al. 2000) show that a perfect elimination ordering of a chordal graph may be found efficiently using an algorithm known as lexicographic breadth-first search. This algorithm maintains a partition of the vertices of the graph into a sequence of sets; initially this sequence consists of a single set with all vertices. The algorithm repeatedly chooses a vertex v from the earliest set in the sequence that contains previously unchosen vertices, and splits each set S of the sequence into two smaller subsets, the first consisting of the neighbors of v in S and the second consisting of the non-neighbors. When this splitting process has been performed for all vertices, the sequence of sets has one ...
In a big win for Cambridge-based Vertex Pharmaceuticals, the US Food and Drug Administration today approved the companys drug Kalydeco (ivacaftor) to treat a rare form of cystic fibrosis. The drug is approved for patients ages 6 and over who carry the G551D gene mutation, and the news follows the approval last year of Vertexs hepatitis C drug Incivek.
Its not too often that you see a biotech company establish a truly differentiated product portfolio with multi-billion dollar potential and minimal competition, but Vertex (Nasdaq:VRTX) seems to be doing exactly that. This one-time specialist in virology is already well on the way to more than $5 billion in potential revenue, and could ultimately see nearly double that amount if clinical trials go the right way. This may ultimately put the company in the "nice problem to have" category of figuring out how to reinvest the proceeds and determining whether or not further investments in the hepatitis C program are worthwhile ...
Vertex I-Supra C+ Sumps are dropped shipped directly from the manufacturer. Due to their size we are unable to have them on hand in our warehouse. Drop ship items do not ship today as indicated above, however the order with the manufacturer wil
Vertex Pharmaceuticals Inc (VRTX.O) said on Sunday that it expected full-year 2017 revenue from its Orkambi cystic fibrosis treatment of $1.1 billion to $1.3 billion and revenue from its Kalydeco treatment of $690 million to $710 million.
... ,It is a comprehensive modular implant system with multiple fixation options designed to better treat each patient-specific anatomy.,medicine,medical supply,medical supplies,medical product
Some notes on a problem with .ase models with more than 1024 polygons and smoothing groups not lighting properly for both vertex lighting and lightmaps.
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GB virus C (GBV-C), which is highly prevalent among HIV/AIDS, seemed to slow the HIV disease progression. The HIV/GBV-C co-infected individuals may represent an interesting model for the investigation of the role played by HIV infection and/or the immune system in driving the evolution of the GBV-C viral populations. The present study investigated the prevalence and population dynamics of GB virus C in HIV infected individuals representing 13 geographic regions of Hubei Province of China. Approximately 37% of HIV-1 infected individuals were infected with GBV-C and genotype 3 is appeared to be predominant. Utilizing the 196 complete E2 nucleotide sequence data from 10 HIV/GBV-C infected individuals and employing coalescence based phylogenetic approaches; the present study has investigated the intra-host dynamics of GBV-C. The results revealed patient-specific unique GBV-C viral lineages and each viral lineage showed the evidence of rapid population expansion in respective HIV-1 infected patients, thus
VERTEX PHARMACEUTICALS INC.. Telaprevir sales have declined faster than Cambridge-based Vertex anticipated. A second-generation hepatitis C drug is in the works.. With it sights set on solving a different illness, Vertex Pharmaceuticals Inc., is selling off royalty rights to the sale of its hepatitis C treatment in overseas markets to the Belgian drug company Janssen Pharmaceutica NV for $152 million.. The royalty exchange is another sign of how fast Vertex is moving on from the drug, telaprevir, after sales of the treatment plummeted in the face of new competition.. While Vertex has a second-generation hepatitis C drug in the works, its new focus is developing a treatment for cystic fibrosis.. The money from Janssen will be used to advance its work on drugs for cystic fibrosis and other conditions, Vertex said in a statement.. Last month, the Cambridge biotech said it would cut 17 percent of its workforce, including 175 jobs in Massachusetts, and return $4.4 million in state tax incentives it ...
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The Pest Management Regulatory Agency (PMRA) invites the public to submit written comments on the proposed registration decision for cyantraniliprole and Ference Insecticide.
Continued Productivity in Research. Vertex continues to focus its research efforts in the areas of infectious diseases, including viral infections - such as influenza - and bacterial infections, inflammatory diseases, cancer and neurological disorders, including pain. Vertex expects additional development candidates for the treatment of one or more of these diseases to emerge from research in 2012. The company will report full-year 2011 financial results and financial guidance on February 2, 2012 . Webcast. Vertex Pharmaceuticals will webcast its corporate presentation at the 30th Annual J.P. Morgan Healthcare Conference on January 9, 2012 at 11:00 a.m. PT ( 2:00 p.m. ET ). A link to the live webcast will be available via Vertexs website, www.vrtx.com, in the Events & Presentations section. An archived webcast of the presentation will be available on Vertexs website through January 23, 2012 . About Vertex. Vertex creates new possibilities in medicine. Our team discovers, develops and ...
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A subtree P of a given tree T is a bottom-up subtree of T if, for each internal vertex u of P, all the children of u in T are also vertices of P. Our problem is deciding if a pattern tree P of m vertices is a bottom-up subtree of a text tree T of n vertices, m ,= n, and, in the affirmative case, finding all the occurrences of P in T. If the vertices are labeled, the labels in the corresponding positions in P and T must match. We consider unordered rooted trees with labeled vertices, which are reconducted to simpler ordered trees through an ordering algorithm. Processing time depends on the label format. If the labels are single characters of a constant or of an n-integer alphabet \Sigma (respectively, ,\Sigma, = constant, or \Sigma is composed of integers in the range [1 \div n]), the problem is solved in O(m +\log n) time and \Theta(m) additional space, after a preprocessing of T is done in \Theta(n) time and \Theta(n) additional space. The number of occurrences of P in T does not appear in the ...
11 October 2002 00:00 in CM221. "Consider the d-dimensional lattice Z^d where each vertex is `open or `closed with probability p or 1-p respectively. An open vertex v is connected by an edge to the closest open vertex w such that the dth co-ordinates of v and w satisfy w(d) = v(d) -1. In case of non-uniqueness of such a vertex w, we choose any one of the closest vertices with equal probability and independently of the other random mechanisms. It is shown that this random graph is a tree almost surely for d=2 or 3 and it is an infinite collection of distinct trees for d >=4. In addition, for any dimension, we show that there is no bi-infinite path in the tree ...
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From BioPortfolio: After years of negotiations, NHS England has signed an agreement with Vertex Pharmaceuticals to make the company’s suite of cystic fibrosis medicines avai...
A team of Chinese and Danish researchers has identified 500 new species of gut-residing microorganisms and 800 new bacterial viruses which could attack them. The findings could lead to promising new t...
 Quadratic Functions Ex) Graph (sketch) f(x)=(x-3) 2 +5  Vertex:  Opens:  Axis of Symmetry Equation of a Quadratic Function in Vertex Form f(x)=a(x-h) 2 +k  Vertex:Axis of Symmetry:  a:
... they are translated, they are moved through a system of internal membranes before being distributed throughout the rest of the cell. At some point in the process, they are modified to their functional form ...
Caldentey J, Hänninen AL, Bamford DH (1994). "Gene XV of bacteriophage PRD1 encodes a lytic enzyme with muramidase activity". ... Rydman PS, Bamford DH (2003). "Identification and mutational analysis of bacteriophage PRD1 holin protein P35". J Bacteriol. ... "Identification and functional analysis of the Rz/Rz1-like accessory lysis genes in the membrane-containing bacteriophage PRD1 ... mobile arms and membrane-capsid interactions in the bacteriophage PRD1 capsid". Nature Structural Biology. 9 (10): 756-63. doi: ...
Rydman, Pia S.; Bamford, Dennis H. (2003-07-01). "Identification and mutational analysis of bacteriophage PRD1 holin protein ... The PRD1 Phage P35 Holin (P35 Holin) Family (TC# 1.E.5) is a member of Holin Superfamily III. The prototype for this family is ... The reaction catalyzed by P35 holin is: autolysin (in) → autolysin (out) Bacteriophage Phage typing Holin Lysin Transporter ... The original text was at "1.E.5 The PRD1 Phage P35 Holin (P35 Holin) Family".. ...
Benson SD, Bamford JK, Bamford DH, Burnett RM (1999). "Viral evolution revealed by bacteriophage PRD1 and human adenovirus coat ... The largest bacteriophage known is Klebsiella Phage vB_KleM-RaK2 which has a genome of 346 kilobases. A recently proposed clade ... Several dsDNA bacteriophages and the herpesviruses encode a powerful ATP driven DNA translocating machine that encapsidates a ... To a lesser extent this gene is also found in T4-like bacteriophages suggesting a common ancestor for these two groups of ...
For example, the bacteriophage PRD1, Paramecium bursaria Chlorella algal virus, and mammalian adenovirus have been placed in ... classified bacteriophage Bam35 - Proc. Natl. Acad. Sci. U.S.A. 103, 3669 (2006); 102, 18944 (2005); Structure 13, 1819 (2005) ... Some viruses, such as bacteriophages, have developed more complicated structures due to constraints of elasticity and ... An elongated icosahedron is a common shape for the heads of bacteriophages. Such a structure is composed of a cylinder with a ...
Thermus thermophilus bacteriophage p23-77 Thermus thermophilus phagein in93 Family: Tectiviridae Genus: Tectivirus Bacillus ... phage AP50 Bacillus phage Bam35 Enterobacteria phage PRD1 Thermus phage P37-14 Genus: Unassigned Bacillus phage phiNS11 Family ...
... bacteriophage p2 MeSH B04.123.205.320 --- bacteriophage phi x 174 MeSH B04.123.205.350 --- bacteriophage prd1 MeSH B04.123. ... bacteriophage p22 MeSH B04.123.900.150 --- bacteriophage prd1 MeSH B04.265.600.400 --- harvey murine sarcoma virus MeSH B04.265 ... bacteriophage phi x 174 MeSH B04.123.660.535 --- bacteriophage pf1 MeSH B04.123.660.550 --- bacteriophage phi 6 MeSH B04.123. ... bacteriophage p1 MeSH B04.123.150.500.305 --- bacteriophage p2 MeSH B04.123.150.500.350 --- bacteriophage t4 MeSH B04.123. ...
... this has become known as the PRD1-adenovirus lineage. Although most members of this group are icosahedral, a few families such ... "Insights into Virus Evolution and Membrane Biogenesis from the Structure of the Marine Lipid-Containing Bacteriophage PM2". ...
Protein-primed replication of the bacteriophage PRD1 genome in vitro: Development of in vitro DNA replication system and ... Protein-primed replication of the bacteriophage PRD1 genome in vitro: Development of in vitro DNA replication system and ... Protein-primed replication of the bacteriophage PRD1 genome in vitro: Development of in vitro DNA replication system and ... The origin and direction of PRD1 DNA replication in vitro were determined by restriction enzyme analysis of ³²P-labeled PRD1 ...
Caldentey J, Hänninen AL, Bamford DH (1994). "Gene XV of bacteriophage PRD1 encodes a lytic enzyme with muramidase activity". ... Rydman PS, Bamford DH (2003). "Identification and mutational analysis of bacteriophage PRD1 holin protein P35". J Bacteriol. ... "Identification and functional analysis of the Rz/Rz1-like accessory lysis genes in the membrane-containing bacteriophage PRD1 ... mobile arms and membrane-capsid interactions in the bacteriophage PRD1 capsid". Nature Structural Biology. 9 (10): 756-63. doi: ...
The same viral jelly-roll fold has also been described at least for bacteriophage PRD1 (family Tectiviridae) (Benson et al., ... Bacteriophage PM2 infects Gram-negative bacteria. Currently, PM2 does not share any significant sequence similarity to any ... PM2 is the first bacteriophage in which the presence of lipids in the virion was demonstrated. Since only one genus ...