AnatomyOrganismsChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesTechnology, Industry, AgricultureInformation Science
BacteriocinsPediococcusLactobacillusPyocinsNisinListeriaLactobacillaceaeGram-Positive Asporogenous RodsAntibiosisLactococcusColicinsGram-Positive BacteriaLactobacillus acidophilusAmino Acid SequenceMolecular Sequence DataLactococcus lactisLeuconostocEnterococcus faeciumListeria monocytogenesStreptococcus mutansEnterococcus faecalisAnti-Bacterial AgentsHafnia alveiMicrobial Sensitivity TestsStreptococcusBacteriaYogurtClostridium perfringensEnterococcusSequence Homology, Amino AcidGenes, BacterialBacterial ProteinsFood PreservationMitomycinsSequence AlignmentBacteriophagesSpheroplastsDNA, BacterialBase SequenceBacillusGene Expression Regulation, Bacterial
Bacteriocins
Substances elaborated by specific strains of bacteria that are lethal against other strains of the same or related species. They are protein or lipopolysaccharide-protein complexes used in taxonomy studies of bacteria.
Pediococcus
A genus of gram-positive, facultatively anaerobic bacteria whose growth is dependent on the presence of a fermentable carbohydrate. No endospores are produced. Its organisms are found in fermenting plant products and are nonpathogenic to plants and animals, including humans.
Lactobacillus
A genus of gram-positive, microaerophilic, rod-shaped bacteria occurring widely in nature. Its species are also part of the many normal flora of the mouth, intestinal tract, and vagina of many mammals, including humans. Pathogenicity from this genus is rare.
Pyocins
Bacteriocins elaborated by mutant strains of Pseudomonas aeruginosa. They are protein or protein-lipopolysaccharide complexes lethal to other strains of the same or related species.
Nisin
A 34-amino acid polypeptide antibiotic produced by Streptococcus lactis. It has been used as a food preservative in canned fruits and vegetables, and cheese.
Listeria
A genus of bacteria which may be found in the feces of animals and man, on vegetation, and in silage. Its species are parasitic on cold-blooded and warm-blooded animals, including man.
Lactobacillaceae
A family of gram-positive bacteria found regularly in the mouth and intestinal tract of man and other animals, in food and dairy products, and in fermenting vegetable juices. A few species are highly pathogenic.
Gram-Positive Asporogenous Rods
A gram-positive, non-spore-forming group of bacteria comprising organisms that have morphological and physiological characteristics in common.
Antibiosis
A natural association between organisms that is detrimental to at least one of them. This often refers to the production of chemicals by one microorganism that is harmful to another.
Lactococcus
A genus of gram-positive, coccoid bacteria mainly isolated from milk and milk products. These bacteria are also found in plants and nonsterile frozen and dry foods. Previously thought to be a member of the genus STREPTOCOCCUS (group N), it is now recognized as a separate genus.
Colicins
Bacteriocins elaborated by strains of Escherichia coli and related species. They are proteins or protein-lipopolysaccharide complexes lethal to other strains of the same species.
Gram-Positive Bacteria
Bacteria which retain the crystal violet stain when treated by Gram's method.
Lactobacillus acidophilus
A species of gram-positive, rod-shaped bacteria isolated from the intestinal tract of humans and animals, the human mouth, and vagina. This organism produces the fermented product, acidophilus milk.
Amino Acid Sequence
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Lactococcus lactis
A non-pathogenic species of LACTOCOCCUS found in DAIRY PRODUCTS and responsible for the souring of MILK and the production of LACTIC ACID.
Leuconostoc
A genus of gram-positive, facultatively anaerobic bacteria whose growth is dependent on the presence of a fermentable carbohydrate. It is nonpathogenic to plants and animals, including humans.
Enterococcus faecium
A species of gram-positive, coccoid bacteria whose organisms are normal flora of the intestinal tract. Unlike ENTEROCOCCUS FAECALIS, this species may produce an alpha-hemolytic reaction on blood agar and is unable to utilize pyruvic acid as an energy source.
Listeria monocytogenes
A species of gram-positive, rod-shaped bacteria widely distributed in nature. It has been isolated from sewage, soil, silage, and from feces of healthy animals and man. Infection with this bacterium leads to encephalitis, meningitis, endocarditis, and abortion.
Streptococcus mutans
A polysaccharide-producing species of STREPTOCOCCUS isolated from human dental plaque.
Enterococcus faecalis
A species of gram-positive, coccoid bacteria commonly isolated from clinical specimens and the human intestinal tract. Most strains are nonhemolytic.
Anti-Bacterial Agents
Substances that reduce the growth or reproduction of BACTERIA.
Hafnia alvei
The type species for the genus HAFNIA. It is distinguished from other biochemically similar bacteria by its lack of acid production on media containing sucrose. (From Bergey's Manual of Determinative Bacteriology, 9th ed)
Microbial Sensitivity Tests
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
Streptococcus
A genus of gram-positive, coccoid bacteria whose organisms occur in pairs or chains. No endospores are produced. Many species exist as commensals or parasites on man or animals with some being highly pathogenic. A few species are saprophytes and occur in the natural environment.
Bacteria
One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.
Yogurt
A slightly acid milk food produced by fermentation due to the combined action of Lactobacillus acidophilus and Streptococcus thermophilus.
Clostridium perfringens
The most common etiologic agent of GAS GANGRENE. It is differentiable into several distinct types based on the distribution of twelve different toxins.
Enterococcus
A genus of gram-positive, coccoid bacteria consisting of organisms causing variable hemolysis that are normal flora of the intestinal tract. Previously thought to be a member of the genus STREPTOCOCCUS, it is now recognized as a separate genus.
Sequence Homology, Amino Acid
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
Genes, Bacterial
The functional hereditary units of BACTERIA.
Bacterial Proteins
Proteins found in any species of bacterium.
Food Preservation
Procedures or techniques used to keep food from spoiling.
Mitomycins
A group of methylazirinopyrroloindolediones obtained from certain Streptomyces strains. They are very toxic antibiotics used as ANTINEOPLASTIC AGENTS in some solid tumors. PORFIROMYCIN and MITOMYCIN are the most useful members of the group.
Sequence Alignment
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
Bacteriophages
Viruses whose hosts are bacterial cells.
Spheroplasts
Cells, usually bacteria or yeast, which have partially lost their cell wall, lost their characteristic shape and become round.
DNA, Bacterial
Deoxyribonucleic acid that makes up the genetic material of bacteria.
Base Sequence
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Bacillus
A genus of BACILLACEAE that are spore-forming, rod-shaped cells. Most species are saprophytic soil forms with only a few species being pathogenic.
Gene Expression Regulation, Bacterial
Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria.

Effect of a staphylococcin on Neisseria gonorrhoeae. (1/1664)

Phage group 2 staphylococcal strain UT0002 contains a large 56S virulence plasmid with genes that code for both exfoliative toxin and a specific staphylococcin termed Bac R(1). Four penicillinase-producing strains and three penicillin-susceptible strains of Neisseria gonorrhoeae were killed by Bac R(1). After 30 min of growth of the penicillin-resistant TR1 strain in 62.5 arbitrary units of Bac R(1) per ml, loss of viability was approximately 90%, and, after 5 h, an approximately 99.99% loss of viability was observed. Lysis did not accompany cell death, and 84% of the Bac R(1) added to the growth medium was adsorbed to the gonococcal cells. The extracellular supernatant fluid from a substrain of staphylococcal strain UT0002 cured of the plasmid for Bac R(1) production had no lethal effect on the gonococcal strains. Bac R(1) was also shown to have bactericidal activity against an L-form of N. meningitidis, indicating that the outer envelope of a neisserial cell is not needed for bacteriocin activity. Ten different normal human sera were unable to neutralize Bac R(1) activity. The bacteriocin lacks adsorption specificity. It binds to but does not kill Escherichia coli cells, indicating that the cell envelope of gram-negative organisms can provide protection against the staphylococcin.  (+info)

Temperature and pH conditions that prevail during fermentation of sausages are optimal for production of the antilisterial bacteriocin sakacin K. (2/1664)

Sakacin K is an antilisterial bacteriocin produced by Lactobacillus sake CTC 494, a strain isolated from Spanish dry fermented sausages. The biokinetics of cell growth and bacteriocin production of L. sake CTC 494 in vitro during laboratory fermentations were investigated by making use of MRS broth. The data obtained from the fermentations was used to set up a predictive model to describe the influence of the physical factors temperature and pH on microbial behavior. The model was validated successfully for all components. However, the specific bacteriocin production rate seemed to have an upper limit. Both cell growth and bacteriocin activity were very much influenced by changes in temperature and pH. The production of biomass was closely related to bacteriocin activity, indicating primary metabolite kinetics, but was not the only factor of importance. Acidity dramatically influenced both the production and the inactivation of sakacin K; the optimal pH for cell growth did not correspond to the pH for maximal sakacin K activity. Furthermore, cells grew well at 35 degrees C but no bacteriocin production could be detected at this temperature. L. sake CTC 494 shows special promise for implementation as a novel bacteriocin-producing sausage starter culture with antilisterial properties, considering the fact that the temperature and acidity conditions that prevail during the fermentation process of dry fermented sausages are optimal for the production of sakacin K.  (+info)

The specific genes for lantibiotic mutacin II biosynthesis in Streptococcus mutans T8 are clustered and can be transferred en bloc. (3/1664)

Mutacin II is a ribosomally synthesized peptide lantibiotic produced by group II Streptococcus mutans. DNA sequencing has revealed that the mutacin II biosynthetic gene cluster consists of seven specific open reading frames: a regulator (mutR), the prepromutacin structural gene (mutA), a modifying protein (mutM), an ABC transporter (mutT), and an immunity cluster (mutFEG). Transformations of a non-mutacin-producing strain, S. mutans UA159, and a mutacin I-producing strain, S. mutans UA140, with chromosomal DNA from S. mutans T8 with an aphIII marker inserted upstream of the mutacin II structural gene yielded transformants producing mutacin II and mutacins I and II, respectively.  (+info)

Identification and cloning of an Erwinia carotovora subsp. carotovora bacteriocin regulator gene by insertional mutagenesis. (4/1664)

Avirulent Erwinia carotovora subsp. carotovora CGE234-M403 produces two types of bacteriocin. For the purpose of cloning the bacteriocin genes of strain CGE234M403, a spontaneous rifampin-resistant mutant of this strain, M-rif-11-2, was isolated. By Tn5 insertional mutagenesis using M-rif-11-2, a mutant, TM01A01, which produces the high-molecular-weight bacteriocin but not the low-molecular-weight bacteriocin was obtained. By thermal asymmetric interlaced PCR, the DNA sequence from the Tn5 insertion site and the DNA sequence of a contiguous 1,280-bp region were determined. One complete open reading frame (ORF), designated ORF2, was identified within the sequenced fragment. The 3' end of another ORF, ORF1, was located upstream of ORF2. A noncoding region and a putative promoter were located between ORF1 and ORF2. Downstream from ORF2, the 5' end of another ORF (ORF3) was found. Deduction from the nucleotide sequence indicated that ORF2 encodes a protein of 99 amino acids, which showed high homology with Yersinia enterocolitica Yrp, a regulator of enterotoxin (Y-ST) production; Escherichia coli host factor 1, required for Qbeta-replicase; and Azorhizobium caulinodans NrfA, required for the expression of nifA. ORF2 was designated brg, bacteriocin regulator gene. A fragment containing ORF2 and its promoter was amplified and cloned into pBR322 and pHSG415r, and the recombinant plasmids, pBYL1 and pHYL1, were transferred into E. coli DH5. Plasmid pBYL1 was reisolated and transferred into the insertion mutant TM01A01. Transformants carrying the plasmid, which was reisolated and designated pBYL1, re-produced the low-molecular-weight bacteriocin.  (+info)

Escherichia coli outer membrane protein TolC is involved in production of the peptide antibiotic microcin J25. (5/1664)

A Tn5 insertion in tolC eliminated microcin J25 production. The mutation had little effect on the expression of the microcin structural gene and presumably acted by blocking microcin secretion. The tolC mutants carrying multiple copies of the microcin genes were less immune to the microcin. TolC is thus likely a component of a microcin export complex containing the McjD immunity protein, an ABC exporter.  (+info)

Inactivation of the dlt operon in Staphylococcus aureus confers sensitivity to defensins, protegrins, and other antimicrobial peptides. (6/1664)

Positively charged antimicrobial peptides with membrane-damaging activity are produced by animals and humans as components of their innate immunity against bacterial infections and also by many bacteria to inhibit competing microorganisms. Staphylococcus aureus and Staphylococcus xylosus, which tolerate high concentrations of several antimicrobial peptides, were mutagenized to identify genes responsible for this insensitivity. Several mutants with increased sensitivity were obtained, which exhibited an altered structure of teichoic acids, major components of the Gram-positive cell wall. The mutant teichoic acids lacked D-alanine, as a result of which the cells carried an increased negative surface charge. The mutant cells bound fewer anionic, but more positively charged proteins. They were sensitive to human defensin HNP1-3, animal-derived protegrins, tachyplesins, and magainin II, and to the bacteria-derived peptides gallidermin and nisin. The mutated genes shared sequence similarity with the dlt genes involved in the transfer of D-alanine into teichoic acids from other Gram-positive bacteria. Wild-type strains bearing additional copies of the dlt operon produced teichoic acids with higher amounts of D-alanine esters, bound cationic proteins less effectively and were less sensitive to antimicrobial peptides. We propose a role of the D-alanine-esterified teichoic acids which occur in many pathogenic bacteria in the protection against human and animal defense systems.  (+info)

Membrane topology of the lactococcal bacteriocin ATP-binding cassette transporter protein LcnC. Involvement of LcnC in lactococcin a maturation. (7/1664)

Many non-lantibiotic bacteriocins of lactic acid bacteria are produced as precursors with N-terminal leader peptides different from those present in preproteins exported by the general sec-dependent (type II) secretion pathway. These bacteriocins utilize a dedicated (type I) secretion system for externalization. The secretion apparatus for the lactococcins A, B, and M/N (LcnA, B, and M/N) from Lactococcus lactis is composed of the two membrane proteins LcnC and LcnD. LcnC belongs to the ATP-binding cassette transporters, whereas LcnD is a protein with similarities to other accessory proteins of type I secretion systems. This paper shows that the N-terminal part of LcnC is involved in the processing of the precursor of LcnA. By making translational fusions of LcnC to the reporter proteins beta-galactosidase (LacZ) and alkaline phosphatase (PhoA*), it was shown that both the N- and C-terminal parts of LcnC are located in the cytoplasm. As the N terminus of LcnC is required for LcnA maturation and is localized in the cytoplasm, we conclude that the processing of the bacteriocin LcnA to its mature form takes place at the cytosolic side of the cytoplasmic membrane.  (+info)

Effects of antibiotics on metabolism of peptidoglycan, protein, and lipids in Bifidobacterium bifidum subsp. pennsylvanicus. (8/1664)

The formation of cell envelope components of Bifidobacterium bifidum subsp. pennsylvanicus was studied by measuring the incorporation of [(3)H]glycine, (14)C-labeled fatty acids, and N-benzoyl-[(14)C]glucosamine into the membrane protein, membrane lipids, and cell wall peptidoglycan, respectively. Inhibition of peptidoglycan synthesis by antibiotics (penicillin G, vancomycin, d-cycloserine, and bacitracin) and by the omission of glucosamine-containing growth factors caused a marked decrease in glycine incorporation into cellular as well as membrane protein, which was accompanied by a considerable enhancement of fatty acid incorporation. The uncoupling of protein and lipid synthesis led to the release of marked amounts of lipids from the cell under these conditions. Arrestment of protein synthesis by antibiotics (chloramphenicol, tetracycline, and actinomycin D) decreased peptidoglycan and lipid synthesis only partially, but did not lead to lipid release. Mg(2+) deficiency of the medium caused about 60% inhibition of growth and lipid synthesis, but protein synthesis and especially peptidoglycan synthesis were much less inhibited. Staphylococcin 1580 arrested the growth and also the synthesis of protein and peptidoglycan. However, the synthesis and turnover of lipids were considerably increased and a release of large amounts of lipids was observed. Peptidoglycan and cellular protein did not show any turnover either during normal growth or after the inhibition of cell wall and protein synthesis.  (+info)

Class II bacteriocin - WikipediaClass II bacteriocin - Wikipedia
Class II bacteriocins are a class of small peptides that inhibit the growth of various bacteria. Many Gram-positive bacteria produce ribosomally synthesized antimicrobial peptides, termed bacteriocins. Bacteriocins for which disulfide bonds are the only modification to the peptide are Class II bacteriocins. One important and well studied class of bacteriocins is the class IIa or pediocin-like bacteriocins produced by lactic acid bacteria. All class IIa bacteriocins are produced by food-associated strains, isolated from a variety of food products of industrial and natural origins, including meat products, dairy products and vegetables. Class IIa bacteriocins are all cationic, display anti-Listeria activity, and kill target cells by permeabilizing the cell membrane. Class IIa bacteriocins contain between 37 and 48 residues. Based on their primary structures, the peptide chains of class IIa bacteriocins may be divided roughly into two regions: a hydrophilic, cationic and highly conserved N-terminal ...
https://en.wikipedia.org/wiki/Class_II_bacteriocin
Class IIa bacteriocins from lactic acid bacteria: Antibacterial activity and food preservation<...
TY - JOUR. T1 - Class IIa bacteriocins from lactic acid bacteria. T2 - Antibacterial activity and food preservation. AU - Ennahar, Saǐd. AU - Sonomoto, Kenji. AU - Ishizaki, Ayaaki. N1 - Funding Information: Financial support for research in the authors laboratory and the preparation of this manuscript, as well as a fellowship for S. E. were kindly provided by the Japan Society for the Promotion of Science.. PY - 1999. Y1 - 1999. N2 - In the last decade, a variety of ribosomally synthesized antimicrobial peptides, or bacteriocins, produced by lactic acid bacteria have been identified and characterized. As a result of these studies, insight has been gained into various fundamental aspects of biology and biochemistry such as bacteriocin processing and secretion, mechanisms of cell immunity, and structure-function relationships. In parallel, there has been a growing awareness that bacteriocins may be developed into useful antimicrobial food additives. Class IIa bacteriocins can be considered as ...
https://kyushu-u.pure.elsevier.com/ja/publications/class-iia-bacteriocins-from-lactic-acid-bacteria-antibacterial-ac
The Group I Strain of Streptococcus mutans, UA140, Produces Both the Lantibiotic Mutacin I and a Nonlantibiotic Bacteriocin,...The Group I Strain of Streptococcus mutans, UA140, Produces Both the Lantibiotic Mutacin I and a Nonlantibiotic Bacteriocin,...
In this study, we determined the nature of the two antimicrobial substances produced by S. mutans strain UA140; one is identical to mutacin I produced by strain CH43, and the other is a two-peptide nonlantibiotic bacteriocin, which we named mutacin IV. The two peptides of mutacin IV, NlmA and NlmB, are encoded by two genes in a single operon located on contig 450 in the S. mutansgenome database. nlmA encodes a prepeptide of 67 aa, consisting of a 23-aa leader peptide with a double-glycine cleavage site and a 44-aa mature peptide. nlmB encodes a prepeptide of 71 aa consisting of a 22-aa leader peptide, also with a double-glycine processing signal, and a 49-aa mature peptide. The fact that the calculated molecular mass of the mature NlmA and NlmB peptides matches the measured molecular mass of the purified mutacin IV peptides suggests that neither peptide is posttranslationally modified.. The production of lantibiotic mutacin I and nonlantibiotic mutacin IV in UA140 appeared to be regulated by ...
https://aem.asm.org/content/67/1/15?ijkey=f418d264a7510a5a9beb60967e7ce23e421bdf20&keytype2=tf_ipsecsha
eCite - An isolate of Haemophilus haemolyticus produces a bacteriocin-like substance that inhibits the growth of nontypeable...eCite - An isolate of Haemophilus haemolyticus produces a bacteriocin-like substance that inhibits the growth of nontypeable...
An isolate of |i|Haemophilus haemolyticus|/i| produces a bacteriocin-like substance that inhibits the growth of nontypeable |i|Haemophilus influenzae|/i|
http://ecite.utas.edu.au/114980
Microbiology Society Journals | Formicin - a novel broad-spectrum two-component lantibiotic produced by Bacillus...Microbiology Society Journals | Formicin - a novel broad-spectrum two-component lantibiotic produced by Bacillus...
Bacteriocins represent a rather underutilized class of antimicrobials despite often displaying activity against many drug-resistant pathogens. Lantibiotics are a post-translationally modified class of bacteriocins, characterized by the presence of lanthionine and methyllanthionine bridges. In this study, a novel two-peptide lantibiotic was isolated and characterized. Formicin was isolated from Bacillus paralicheniformis APC 1576, an antimicrobial-producing strain originally isolated from the intestine of a mackerel. Genome sequencing allowed for the detection of the formicin operon and, from this, the formicin structural genes were identified, along with those involved in lantibiotic modification, transport and immunity. The identified bacteriocin was subsequently purified from the bacterial supernatant. Despite the degree of conservation seen amongst the entire class of two-peptide lantibiotics, the formicin peptides are unique in many respects. The formicin α peptide is far less hydrophobic than any
http://mic.microbiologyresearch.org/content/journal/micro/10.1099/mic.0.000340
Bacteriocins | Riley LabBacteriocins | Riley Lab
The Role of Bacteriocins in Mediating Bacterial Competitive Interactions. Explaining the coexistence of competing species is a major challenge in community ecology. In bacterial systems, competition is often driven by the production of bacteriocins, which are narrow-spectrum proteinaceous toxins that serve to kill closely related species, providing the producer better access to limited resources. Bacteriocin producers have been shown to competitively exclude sensitive, nonproducing strains. However, the dynamics between bacteriocin producers, each lethal to its competitor, are largely unknown. In this study, we used in vitro, in vivo and in silico models to study competitive interactions between bacteriocin producers. Two Escherichia coli strains were generated, each carrying a DNA-degrading bacteriocin (colicins E2 and E7). Using reporter-gene assays, we showed that each DNase bacteriocin is not only lethal to its opponent but, at lower doses, can also induce the expression of its opponents ...
http://www.bio.umass.edu/biology/riley/node/73
ORBi: Browsing ORBiORBi: Browsing ORBi
in PLoS ONE (2013), 8(12), Background: Lantibiotics are heat-stable peptides characterized by the presence of thioether amino acid lanthionine and methyllanthionine. They are capable to inhibit the growth of Gram-positive bacteria ... [more ▼]. Background: Lantibiotics are heat-stable peptides characterized by the presence of thioether amino acid lanthionine and methyllanthionine. They are capable to inhibit the growth of Gram-positive bacteria, including Listeria monocytogenes, Staphylococcus aureus or Bacillus cereus, the causative agents of food-borne diseases or nosocomial infections. Lantibiotic biosynthetic machinery is encoded by gene cluster composed by a structural gene that codes for a pre-lantibiotic peptide and other genes involved in pre-lantibiotic modifications, regulation, export and immunity. Methodology/Findings: Bacillus amyloliquefaciens GA1 was found to produce an antimicrobial peptide, named amylolysin, active on an array of Gram-positive bacteria, including methicillin ...
http://orbi.ulg.ac.be/browse?type=author&value=Terrak%2C+Mohammed+p002422
ScholarWorks at University of Montana - University of Montana Conference on Undergraduate Research (UMCUR): Alternative roles...ScholarWorks at University of Montana - University of Montana Conference on Undergraduate Research (UMCUR): Alternative roles...
Bacteriocins are multi-protein assemblies that bear striking resemblance to bacteriophage (virus) tails. Bacteriocins are an extracellular contractile injection system that kill closely related bacteria by puncturing their cell membrane. Mounting evidence suggests that besides interbacterial competition, bacteriocins also mediate interactions between bacteria and diverse eukaryotic hosts by assembling extracellular hexagonal-bacteriocin arrays composed of numerous bacteriocin particles. Pseudomonas aeruginosa is an opportunistic bacterial pathogen that produces bacteriocins called R2 pyocins which lyse susceptible bacteria. Based on homology to other contractile injection systems, we hypothesize that P. aeruginosa produces bacteriocin arrays that modulate host responses during infection. We have developed a method to quantify R2 pyocins utilizing the lysis of susceptible strains of P. aeruginosa. We are currently applying this quantification method to optimize the production and purification of pyocins
https://scholarworks.umt.edu/umcur/2020/lifesciences_poster/9/
Effect of Hydrostatic Pressure and Electroporation on Bactericidal Efficiency in Combination with Bacteriocins and Lysozyme....
The bactericidal efficiency of ultrahigh hydrostatic pressure (UMP) and pulsed electric field (PEF) were studied in combination with two acteriocins, nisin A and pediocin AcH, and lysozyme. Several Gram-positive and Gram-negative bacterial species and strains associated with food spoilage and foodborne diseases were tested. The results showed that both UHP and PEF inflict lethal and sublethal injury to Gram-positive and Gram-negative bacterial cells. As the sublethally-injured cells became sensitive to the bactericidal action of the two bacteriocins and lysozyme, the combination of the UHP and PEF treatment, along with bacteriocin and lysozyme resulted in greater viability loss than when only the UHP or PEF are used. In general, under the study conditions, UHP and bacteriocins produced more viability loss than PEF with and without bacteriocins. By combining bacteriocins and lysozyme, UHP at 30,000 psi for 1 min produced viability loss of 13.8 logs in Listeria monocytogenes Scott A and 6.3 logs in
http://oai.dtic.mil/oai/oai?verb=getRecord&metadataPrefix=html&identifier=ADA315125
Genetic Characterization and Heterologous Expression of Brochocin-C, an Antibotulinal, Two-Peptide Bacteriocin Produced by...Genetic Characterization and Heterologous Expression of Brochocin-C, an Antibotulinal, Two-Peptide Bacteriocin Produced by...
Brochocin-C is a two-peptide class IIb bacteriocin (18) with a broad spectrum that compares favorably with the antibacterial spectrum of nisin, inhibiting the outgrowth of Bacillus andClostridium spores, including spores of C. botulinum. This is exceptional because the structure of brochocin-C is not comparable to that of nisin. Nisin does not require a receptor to permeabilize the membranes of sensitive cells, and it inhibits gram-negative bacteria pretreated with EDTA (32). Brochocin-C was also active against E. coli and S. choleraesuis cells treated with EDTA, although the degree of inhibition that we observed for nisin and brochocin-C was less than that reported for nisin by Stevens et al. (32). This suggests that brochocin-C also does not require a receptor to be active. Plasmid pJKM64 is lethal in E. coli when Sec-dependent production of brochocin-C is introduced, and this provides further evidence that brochocin-C is active in E. coli and does not need a receptor. Thermophilin 13 is a ...
https://aem.asm.org/content/64/12/4757
Lantibiotic mersacidin elisa and antibodyLantibiotic mersacidin elisa and antibody
Shop Lantibiotic mersacidin ELISA Kit, Recombinant Protein and Lantibiotic mersacidin Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
https://www.mybiosource.com/protein_family.php?root=lantibiotic-mersacidin
In vitro evaluation of bacteriocinlike inhibitory substances produced by lactic acid bacteria isolated during traditional...
TY - JOUR. T1 - In vitro evaluation of bacteriocinlike inhibitory substances produced by lactic acid bacteria isolated during traditional sicilian cheese making. AU - Macaluso, Giusi. AU - Gaglio, Raimondo. AU - Scatassa, Maria Luisa. AU - Mancuso, Isabella. AU - Macaluso, Giusi. AU - Fiorenza, Gerlando. PY - 2016. Y1 - 2016. N2 - Bacteriocins are antimicrobial proteins produced by bacteria that inhibit the growth of other bacteria with a bactericidal or bacteriostatic mode of action. Many lactic acid bacteria (LAB) produce a high diversity of different bacteriocins. Bacteriocinogenic LAB are generally recognised as safe (GRAS) and useful to control the frequent development of pathogens and spoilage microorganisms. For this reason they are commonly used as starter cultures in food fermentations. In this study, the authors describe the results of a screening on 699 LAB isolated from wooden vat surfaces, raw milk and traditional Sicilian cheeses, for the production of bacteriocin-like inhibitory ...
https://pure.unipa.it/it/publications/in-vitro-evaluation-of-bacteriocinlike-inhibitory-substances-prod-3
Anticancer and antimicrobial potential of enterocin 12a from Enterococcus faecium | SpringerLinkAnticancer and antimicrobial potential of enterocin 12a from Enterococcus faecium | SpringerLink
Increase in the number of infections caused by Gram-negative bacteria in neutropenic cancer patients has prompted the search for novel therapeutic agents having dual anticancer and antimicrobial properties. Bacteriocins are cationic proteins of prokaryotic origin that have emerged as one of the most promising alternative antimicrobial agents with applications as food preservatives and therapeutic agents. Apart from their antimicrobial activities, bacteriocins are also being explored for their anticancer potential. In this study, a broad-spectrum, cell membrane-permeabilizing enterocin with a molecular weight of 65 kDa was purified and characterized from the culture supernatant of vaginal Enterococcus faecium 12a. Enterocin 12a inhibited multidrug-resistant strains of various Gram-negative pathogens such as Salmonella enterica, Shigella flexneri, Vibrio cholerae, Escherichia coli and Gram-positive, Listeria monocytogenes, but had no activities against different strains of gut lactobacilli. The mass
https://rd.springer.com/article/10.1186/s12866-021-02086-5?error=cookies_not_supported&code=6337fbc0-6d82-4f84-aa53-c5d91472cf80
Dzung B. Diep | NMBUDzung B. Diep | NMBU
75. Arbulu S, Frantzen C, Lohans CT, Cintas LM, Herranz C, Holo H, Diep DB, Vederas JC, Hernández PE. Draft Genome Sequence of the Bacteriocin-Producing Strain Enterococcus faecium M3K31, Isolated from Griffon Vultures (Gyps fulvus subsp. fulvus). Genome Announc. 2016 Mar 24;4(2). pii: e00055-16.. 74. Askarian F, Ajayi C, Hanssen AM, van Sorge NM, Pettersen I, Diep DB, Sollid JU, Johannessen M. The interaction between Staphylococcus aureus SdrD and desmoglein 1 is important for adhesion to host cells. Sci Rep. 2016 Feb 29;6:22134.. 73.Mirkovic N, Polovic N, Vukotic G, Jovcic B, Miljkovic M, Radulovic Z, Diep DB, Kojic M. Lactococcus lactis LMG2081 Produces Two Bacteriocins, a Nonlantibiotic and a Novel Lantibiotic. Appl Environ Microbiol. 2016 Apr 4;82(8):2555-62.. 2015 (9).. 72. Hassan M, Brede DA, Diep DB, Nes IF, Lotfipour F, Hojabri Z. Efficient Inactivation of Multi-Antibiotics Resistant Nosocomial Enterococci by Purified Hiracin Bacteriocin. Adv Pharm Bull. 2015 Sep;5(3):393-401.. 71. ...
https://www.nmbu.no/ans/dzung.diep
Frontiers | Lectin-Like Bacteriocins | MicrobiologyFrontiers | Lectin-Like Bacteriocins | Microbiology
Bacteria produce a diverse array of antagonistic compounds to restrict growth of microbial rivals. Contributing to this warfare are bacteriocins: secreted antibacterial peptides, proteins and multi-protein complexes. These compounds typically eliminate competitors closely related to the producer. Lectin-like bacteriocins (LlpAs) constitute a distinct class of such proteins, produced by Pseudomonas as well as some other proteobacterial genera. LlpAs share a common architecture consisting of two B-lectin domains, followed by a short carboxy-terminal extension. Two surface-exposed moieties on susceptible Pseudomonas cells are targeted by the respective lectin modules. The carboxy-terminal domain binds D-rhamnose residues present in the lipopolysaccharide layer, whereas the amino-terminal domain interacts with a polymorphic external loop of the outer-membrane protein insertase BamA, hence determining selectivity. The absence of a toxin-immunity module as found in modular bacteriocins and other polymorphic
https://www.frontiersin.org/articles/10.3389/fmicb.2018.02706/full
We survey the feasibility of enterocin AS-48, a circular cationic peptide | Safety, pharmacokinetics, and pharmacodynamic...We survey the feasibility of enterocin AS-48, a circular cationic peptide | Safety, pharmacokinetics, and pharmacodynamic...
We survey the feasibility of enterocin AS-48, a circular cationic peptide produced by promastigotes as well as to axenic and intracellular amastigotes at low micromolar concentrations, with scarce cytotoxicity to macrophages. results provide a proof of mechanism for the search of fresh leishmanicidal bacteriocins, whose diversity constitutes an almost endless source for fresh constructions at moderate production cost and whose safe use on food preservation is well established. at low micromolar concentrations with scarce toxicity on the host cell. Furthermore, it was active on intracellular amastigotes without prior encapsulation, a rare feature in bacteriocins. This work provides a proof mechanism for the usage of membrane-active bacteriocins as a fresh band of leishmanicidal real estate agents, with little sponsor cytotoxicity and inexpensive costs of creation. Outcomes Leishmanicidal and cytotoxic actions of AS-48. The leishmanicidal actions of AS-48 had been assessed from the inhibition of ...
http://at-406.net/we-survey-the-feasibility-of-enterocin-as-48-a-circular-cationic-peptide/
Rational design of syn-safencin, a novel linear antimicrobial peptide derived from the circular bacteriocin safencin AS-48 |...Rational design of syn-safencin, a novel linear antimicrobial peptide derived from the circular bacteriocin safencin AS-48 |...
Bacteriocins hold unprecedented promise as a largely untapped source of antibiotic alternatives in the age of multidrug resistance. Here, we describe the first approach to systematically design variants of a novel AS-48 bacteriocin homologue, which we have termed safencin AS-48, from Bacillus safensis, to gain insights into engineering improved activity of bacteriocins. A library of synthetic peptides in which systematic amino acid substitutions to vary the periodicity and abundance of polar, acidic, aliphatic, and hydrophobic residues were generated for a total of 96 novel peptide variants of a single bacteriocin candidate. Using this method, we identified nine synthetic safencin (syn-safencin) variants with broad and potent antimicrobial activities with minimal inhibitory concentrations (MIC) as low as 250 nM against E. coli, P. aeruginosa, X. axonopodis, and S. pyogenes with minimal cytotoxicity to mammalian cells. It is anticipated that the strategies we have developed will serve as general guides
https://www.nature.com/articles/s41429-018-0032-4?error=cookies_not_supported&code=0ddd4e1d-9515-4a80-aaa6-952f65573086
Genomic analyses of pneumococci reveal a wide diversity of bacteriocins - including pneumocyclicin, a novel circular...
BACKGROUND: One of the most important global pathogens infecting all age groups is Streptococcus pneumoniae (the pneumococcus). Pneumococci reside in the paediatric nasopharynx, where they compete for space and resources, and one competition strategy is to produce a bacteriocin (antimicrobial peptide or protein) to attack other bacteria and an immunity protein to protect against self-destruction. We analysed a collection of 336 diverse pneumococcal genomes dating from 1916 onwards, identified bacteriocin cassettes, detailed their genetic composition and sequence diversity, and evaluated the data in the context of the pneumococcal population structure. RESULTS: We found that all genomes maintained a blp bacteriocin cassette and we identified several novel blp cassettes and genes. The composition of the bacteriocin/immunity region of the blp cassette was highly variable: one cassette possessed six bacteriocin genes and eight putative immunity genes, whereas another cassette had only one of each. Both
https://www.ndm.ox.ac.uk/publications/535611
Biosynthesis of the RiPP trojan horse nucleotide antibiotic microcin C is directed by the N-formyl of the peptide precursor<...Biosynthesis of the RiPP trojan horse nucleotide antibiotic microcin C is directed by the N-formyl of the peptide precursor<...
TY - JOUR. T1 - Biosynthesis of the RiPP trojan horse nucleotide antibiotic microcin C is directed by the N-formyl of the peptide precursor. AU - Dong, Shi Hui. AU - Kulikovsky, Alexey. AU - Zukher, Inna. AU - Estrada, Paola. AU - Dubiley, Svetlana. AU - Severinov, Konstantin. AU - Nair, Satish K.. PY - 2019/1/1. Y1 - 2019/1/1. N2 - Microcin C7 (McC) is a peptide antibiotic modified by a linkage of the terminal isoAsn amide to AMP via a phosphoramidate bond. Post-translational modification on this ribosomally produced heptapeptide precursor is carried out by MccB, which consumes two equivalents of ATP to generate the N-P linkage. We demonstrate that MccB only efficiently processes the precursor heptapeptide that retains the N-formylated initiator Met (fMet). Binding studies and kinetic measurements evidence the role of the N-formyl moiety. Structural data show that the N-formyl peptide binding results in an ordering of residues in the MccB crossover loop, which dictates specificity in ...
https://www.researchwithrutgers.com/en/publications/biosynthesis-of-the-ripp-trojan-horse-nucleotide-antibiotic-micro
Bio-preservative Activities of Partially Purified Bacteriocin Extracts of Lactobacillus mindensis TMW and Lactobacillus tucceti...Bio-preservative Activities of Partially Purified Bacteriocin Extracts of Lactobacillus mindensis TMW and Lactobacillus tucceti...
The preservative potentials of lactic acid bacteria (LAB) recovered from some Nigerian traditional fermented foods were assessed by inoculating 0.1 ml aliquots of suitable dilutions of the food samples on De Man Rogosa Sharpe (MRS) agar fortified with 50mg of nystatin. The isolates were assessed for their ability to produce bacteriocin using Agar Well Diffusion assay method. By using (GTG)5-PCR and 16s rDNA sequencing tools, two bacteriocin-producing LAB namely Lactobacillus tucceti CECT 5920 and Lactobacillus mindensis TMW were identified. Both LAB isolates had equal level of bacteriocin activity. Studies on inhibitory activity of partially purified bacteriocin extracts showed that temperature of 35°C had maximum effect on bacteriocin antimicrobial activity of L. tucceti CECT 5920 against Staphylococcus aureus NCTC 8325 and Escherichia coli 0157:H7, while pH had same effects on both LAB isolates against the test bacteria. Maximum tolerance of acidic medium was exhibited by both LAB isolates at ...
https://www.journalejnfs.com/index.php/EJNFS/article/view/27010
Regulation of Bacteriocin Production in Streptococcus mutans by the Quorum-Sensing System Required for Development of Genetic...Regulation of Bacteriocin Production in Streptococcus mutans by the Quorum-Sensing System Required for Development of Genetic...
Two-component signal transduction systems that respond to the presence of inducer peptide pheromones are known to regulate a variety of processes: bacteriocin production, competence for transformation, biofilm formation, and virulence (30). The results presented here and those from previous studies (14, 15) show that S. mutans uses one and the same TCSTS to control at least three of these at first sight unrelated processes. Mutants in comA, comC, and comDE are competence deficient (14), form biofilms that are different from those formed by wild-type strains (15), and do not produce bacteriocins (this study; 32, 36).. Unlike competence, which exhibits an optimum during a short interval of the exponential phase (data not shown) (19, 23), expression of nlmAB′-lacZ was lowest in this period but reached a maximum in the stationary phase. Since both activities are controlled by the same regulatory system, the question arises as to how this differential regulation is established. The key to the ...
https://jb.asm.org/content/187/12/3980
Consortium receives funding to discover, develop and manufacture new antibiotics - Scienmag: Latest Science and Health NewsConsortium receives funding to discover, develop and manufacture new antibiotics - Scienmag: Latest Science and Health News
The consortium will develop new antibiotics/antimicrobials, which have similar capabilities. The team will work with bacteriocins, potent toxins produced by bacteria to kill other, closely-related strains. Bacteriocins are naturally active in the human body but have not evolved to function as effective drugs in the clinic.. If a way can be found to convert bacteriocins into effective antibiotics, they offer excellent potential for use to address the growing problem of antibiotic resistance and the threat this poses to human and animal health around the world.. The consortium will take a model bacteriocin, discovered by University of Plymouth staff, and enhance its performance in terms of range of action, stability and potency. The aim is to generate derivatives which show drug-like properties without compromising the bacteriocins original potent bacteria-killing abilities. The manufacture of the derivatives will then be scaled-up into commercially attractive production systems.. Mathew Upton, ...
https://scienmag.com/consortium-receives-funding-to-discover-develop-and-manufacture-new-antibiotics/
Bacteriocin - WikipediaBacteriocin - Wikipedia
Cotter PD, Hill C, Ross RP (2006). Whats in a name? Class distinction for bacteriocins. Nature Reviews Microbiology. 4 (2). doi:10.1038/nrmicro1273-c2. is author reply to comment on article :Cotter PD, Hill C, Ross RP (2005). Bacteriocins: developing innate immunity for food. Nature Reviews Microbiology. 3 (?): 777-88. doi:10.1038/nrmicro1273. PMID 16205711. HENG, C. K. N., WESCOMBE, P. A., BURTON, J. P., JACK, R. W., & TAGG, J. R. (2007). The diversity of bacteriocins in Gram-positive bacteria. In: Bacteriocins: Ecology and Evolution. 1st ed., Riley, M. A. & Chavan, M. A., Eds. Springer, Hildberg, p. 45-83. Nissen-Meyer, J; Rogne, P; Oppegård, C; Haugen, HS; Kristiansen, PE (2013-08-12). Structure-function relationships of the non-lanthionine-containing peptide (class II) bacteriocins produced by gram-positive bacteria. Curr Pharm Biotechnol. 10: 19-37. PMID 19149588. NETZ D. J., POHL , BECK-SICKINGER A. G., SELMER , PIERIK , SAHL H. G. (2002). Biochemical characterisation and genetic ...
https://en.wikipedia.org/wiki/Bacteriocin
Molecular analysis of the replication region of the pCIZ2 plasmid from the multiple bacteriocin producer strain Enterococcus...
The sequence analysis of the 7383 bp plasmid pCIZ2 from |i|Enterococcus faecium|/i| L50 enabled the identification of a DNA region involved in its replication. The structural organization of the pCIZ2 replication region is highly similar to those of well-known theta-replicating plasmids. It contains an untranslated region, the putative replication origin (|i|ori|/i|), constituted by two sets of direct repeats of 12 and 22 bp (iterons), and followed by three open-reading frames (|i|orf8|/i| to |i|orf10|/i|). |i|orf8|/i| encodes the replication initiation protein (RepE). The transcriptional start site of the replication locus was identified 13 nucleotides upstream of the |i|repE|/i| start codon. A two-dimensional agarose gel electrophoresis analysis revealed pCIZ2 intermediates profile typical of the theta-type replication mechanism. Subcloning of different DNA fragments of the pCIZ2 replication region in |i|Escherichia coli|/i| and, subsequently, in the plasmidless |i|E. faecium|/i| L50/14-2 allowed the
https://hal-normandie-univ.archives-ouvertes.fr/hal-02180982
Determining the Virulence Properties of Escherichia coli ST131 Containing Bacteriocin-Encoding Plasmids Using Short- and Long...Determining the Virulence Properties of Escherichia coli ST131 Containing Bacteriocin-Encoding Plasmids Using Short- and Long...
Escherichia coli ST131 is a clinical challenge due to its multidrug resistant profile and successful global spread. They are often associated with complicated infections, particularly urinary tract infections (UTIs). Bacteriocins play an important role to outcompete other microorganisms present in the human gut. Here, we characterized bacteriocin-encoding plasmids found in ST131 isolates of patients suffering from a UTI using both short- and long-read sequencing. Colicins Ia, Ib and E1, and microcin V, were identified among plasmids that also contained resistance and virulence genes. To investigate if the potential transmission range of the colicin E1 plasmid is influenced by the presence of a resistance gene, we constructed a strain containing a plasmid which had both the colicin E1 and blaCMY-2 genes. No difference in transmission range was found between transformant and wild-type strains. However, a statistically significantly difference was found in adhesion and invasion ability. ...
https://www.rug.nl/research/portal/publications/determining-the-virulence-properties-of-escherichia-coli-st131-containing-bacteriocinencoding-plasmids-using-short-and-longread-sequencing-and-comparing-them-with-those-of-other-e-coli-lineages
Diamond Publications - Search Results
Abstract: How ultra-high-affinity protein protein interactions retain high specificity is still poorly understood. The interaction between colicin DNase domains and their inhibitory immunity (Im) proteins is an ultra-high-affinity interaction that is essential for the neutralisation of endogenous DNase catalytic activity and for protection against exogenous DNase bacteriocins. The colicin DNase-Im interaction is a model system for the study of high-affinity protein protein interactions. However, despite the fact that closely related colicin-like bacteriocins are widely produced by Gram-negative bacteria, this interaction has only been studied using colicins from Escherichia coli. In this work, we present the first crystal structures of two pyocin DNase-Im complexes from Pseudomonas aeruginosa, pyocin S2 DNase-ImS2 and pyocin AP41 DNase-ImAP41. These structures represent divergent DNase Im subfamilies and are important in extending our understanding of protein protein interactions for this ...
https://publications.diamond.ac.uk/pubman/searchpublicationsadvanced?sort=beamlineTechnicalAreaSortString&authorId=7427&dir=asc&advancedsearch=1&publicationStates%5B4%5D.selected=true
Rev. Microbiol. - vol.30 número4Rev. Microbiol. - vol.30 número4
Production of bacteriocin-like inhibitory substances (BLIS) by Streptococcus salivarius strains isolated from the tongue and throat of children with and without sore throat ...
http://www.scielo.br/scielo.php?script=sci_issuetoc&pid=0001-371419990004&lng=es&nrm=iso
The lantibiotic peptide labyrinthopeptin A1 demonstrates broad anti-HIV and anti-HSV activity with potential for microbicidal...The lantibiotic peptide labyrinthopeptin A1 demonstrates broad anti-HIV and anti-HSV activity with potential for microbicidal...
Lantibiotics are peptides, produced by bacteria, that contain the noncanonicalamino acid lanthionine and many of them exhibit antibacterial activities. The labyrinthopeptin A1 (LabyA1) is a prototype peptide of a novel class of carbacyclic lantibiotics. Here, we extensively evaluated its broad-spectrum activity against HIV and HSV in vitro, studied its mechanism of action and evaluated potential microbicidal applications. LabyA1 exhibited a consistent and broad anti-HIV activity (EC(50)s:0.70-3.3 mu M) and anti-HSV activity (EC(50)s:0.29-2.8 mu M) in cell cultures. LabyA1 also inhibited viral cell-cell transmission between persistently HIV-infected T cells and uninfected CD4(+) T cells (EC50:2.5 mu M) and inhibited the transmission of HIV captured by DC-SIGN(+)-cells to uninfected CD4(+) T cells (EC50:4.1 mu M). Time-of-drug addition studies revealed that LabyA1 acts as an entry inhibitor against HIV and HSV. Cellular and virus binding studies combined with SPR/FLIPR technology showed that ...
https://repository.uantwerpen.be/link/irua/109642
Antibacterial Activity of Lactic Acid Bacteria to Improve Shelf Life of Raw Meat - 文献詳細 - Ceek.jp AltmetricsAntibacterial Activity of Lactic Acid Bacteria to Improve Shelf Life of Raw Meat - 文献詳細 - Ceek.jp Altmetrics
Lactic Acid Bacteria (LAB) are generally recognized as safe. It has been used to increase the shelf-life of fermented products, and its antimicrobial action is based on the metabolites secretions, such as lactic acid, hydrogen peroxide, reuterin, bacteriocins and the like-bacteriocins substances. It has been proven that LAB are able to inhibit deteriorating bacteria of raw meat, but improper handling of live cultures could lead to spoilage. So, the use of their bacteriocins, small antimicrobial peptides, could be an alternative. Besides reducing the number of spoilage bacteria, it seeks to inhibit pathogenic bacteria such as Salmonella, enterohemorrhagic Escherichia coli and Listeria. The food industry uses few bacteriocins and now bacterial resistance has been reported. For that reason, the search of novel bacteriocins produced by LAB is a priority. Moreover, the natural microbiota of meat could be a reservoir of LAB.
http://altmetrics.ceek.jp/article/www.jstage.jst.go.jp/article/bio/24/4/24_185/_article/-char/ja/
Download Lantibiotics And Related PeptidesDownload Lantibiotics And Related Peptides
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Hiracin-JM79 immunity factor elisa and antibodyHiracin-JM79 immunity factor elisa and antibody
Shop Hiracin-JM79 immunity factor ELISA Kit, Recombinant Protein and Hiracin-JM79 immunity factor Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
https://www.mybiosource.com/protein_family.php?root=hiracin-jm79-immunity-factor
Genetical identification of intibacterial agents producing microorganisms and analysis of bacteriocins and killer toxins...Genetical identification of intibacterial agents producing microorganisms and analysis of bacteriocins and killer toxins...
Research on naturally occurring antibacterial agents has attracted considerable scientific attention worldwide over the last twenty years. Instead of chemical food additives, it is possible to use natural antimicrobials released by lactic acid bacteria and yeast. The pure antimicrobials produced by microorganisms or the microorganisms that produce these substances can be used for food bio-preservation or as probiotics in medicine and veterinary medicine. Searching for lactic acid bacteria and yeast in natural foods and researching their application possibilities are relevant worldwide. Depending on the environment, microorganisms adapt, resulting in different strains that can produce antibacterial substances with different properties. Such substances are bacteriocins, produced by lactic acid bacteria and killer toxins, produced by yeast [1, 2]. The aim of this work is genotyping of microorganisms, isolated from cottage cheese, obtained from local milk products producers, which shows ...
https://www.vdu.lt/cris/handle/20.500.12259/99013
Supplementary MaterialsFigure S1: Sequence alignment of BovA-like peptides. and cerecin perecin. | healthweblognews.info
Supplementary MaterialsFigure S1: Sequence alignment of BovA-like peptides. and cerecin perecin. (DOCX) pone.0097121.s006.docx (14K) GUID:?1C8CF4AE-D623-47A1-B72C-E0F9ACA2104D Desk S3: MS analysis of disulfide substitution mutants of bovicin HJ50-like lantibiotics. (DOCX) pone.0097121.s007.docx (14K) GUID:?E15E4680-DDEC-449D-A1DF-6B67DED929CA Data Availability StatementThe authors concur that all data fundamental the findings are fully obtainable without restriction. The cerecin biosynthesis gene cluster from B. cereus As 1.348 was submitted to GenBank with an accession amount of KJ504103 as well as the thuricin biosynthesis gene cluster in B. thuringiensis As 1.013 was submitted with an accession amount of KJ504104. Abstract Lantibiotics are ribosomally-synthesized and modified peptides with potent antimicrobial actions posttranslationally. Finding of book lantibiotics continues to be accelerated using the soaring launch of genomic info of microorganisms greatly. As a distinctive course II ...
http://healthweblognews.info/supplementary-materialsfigure-s1-sequence-alignment-of-bova-like-peptides-and-cerecin-perecin/
Lachnobacterium bovis Whitford et al. ATCC ® BAA-151™Lachnobacterium bovis Whitford et al. ATCC ® BAA-151™
Lachnobacterium bovis ATCC ® BAA-151™ Designation: LRC 5382 TypeStrain=True Application: Produces bacteriocin-like inhibitory substance
https://www.atcc.org/en/Products/Cells_and_Microorganisms/Bacteria/Alphanumeric_Genus__Species/BAA-151.aspx?slp=1
Cross-immunity and immune mimicry as mechanisms of resistance to the lantibiotic lacticin 3147. - PubMed - NCBICross-immunity and immune mimicry as mechanisms of resistance to the lantibiotic lacticin 3147. - PubMed - NCBI
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
https://www.ncbi.nlm.nih.gov/pubmed/19183281?dopt=Abstract
Peptide BacteriocinsPeptide Bacteriocins
The a- and p-peptides of enterocin 1071 and lactococcin G and Q have putative amphiphilic a-helices in their N-terminal and mid region (residues 3-27 in a and 8-25 in p) as judged by displaying their sequences on an Ed-mundson a-helical wheel 6, 8, 9 . The non-polar amino acids are found almost exclusively on one side of the helix while the polar residues are found on the opposite side. CD structural studies of the lactococcin G a- and p-peptides and fragments thereof show that the a- and.... ...
https://www.americorpshealth.biz/peptide-bacteriocins/
Lantibiotic lichenicidin A2 - Creative PeptidesLantibiotic lichenicidin A2 - Creative Peptides
Creative Peptides offers Lantibiotic lichenicidin A2 for your research. We also provide custom peptide synthesis, process development, GMP manufacturing.
https://www.creative-peptides.com/product/lantibiotic-lichenicidin-a2-item-af2072-31044.html
OPAL - OHIO PRIVATE ACADEMIC LIBRARIES / Muskingum
The Diversity of Bacteriocins in Gram-Negative Bacteria -- Molecular Evolution of Bacteriocins in Gram-Negative Bacteria -- The Diversity of Bacteriocins in Gram-Positive Bacteria -- Peptide and Protein Antibiotics from the Domain Archaea: Halocins and Sulfolobicins -- The Ecological and Evolutionary Dynamics of Model Bacteriocin Communities -- Bacteriocins Role in Bacterial Communication ...
https://cat.opal-libraries.org/search~S16?/jBacteria+--+classification./jbacteria+classification/-3%2C-1%2C0%2CB/frameset&FF=jbacteriocins&1%2C1%2C
Three-Dimensional Structure in Lipid Micelles of the Pediocin-like Antimicrobial Peptide Sakacin P and a Sakacin P Variant That...Three-Dimensional Structure in Lipid Micelles of the Pediocin-like Antimicrobial Peptide Sakacin P and a Sakacin P Variant That...
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https://www.infona.pl/resource/bwmeta1.element.acs-doi-10_1021_bi034572i
Search Articles | University of Toronto Libraries
in patients with indwelling medical devices. The present study examined the effects of different kinds of bacteriocins, which are ribosomally synthesized antimicrobial peptides produced by certain bacteria, on biofilms formed by a clinical ...
https://query.library.utoronto.ca/index.php/search/q?kw=SubjectTerms:Plankton%20-%20drug%20effects
Use of Bacteriocins For Promoting Plant Growth and Disease Resistance - MCGILL UNIVERSITYUse of Bacteriocins For Promoting Plant Growth and Disease Resistance - MCGILL UNIVERSITY
A method for promoting plant growth and/or disease resistance comprising applying a purified polypeptide that is a bacteriocin and that possesses plant growth and/or disease resistance promoting activ
https://www.freepatentsonline.com/y2008/0248953.html
Whats the matter with M.D.s?Whats the matter with M.D.s?
Also, some antibiotic-resistant bacteria are actually less virulent than the sensitive bacteria, again implying a cost to the host for holding on to the plasmid. These resistant bacteria are often crowded out by the normal bacterial flora of the body. However, if the body is exposed to antibiotic, the sensitive bacteria die off, and the resistant bacteria are able to grow out and express their virulence.. Antibiotic resistance is certainly a matter of natural selection, but its more than just that. For example, all it takes in an ICU to have an outbreak of certain resistant strains is for one inoculum to be brought in. That inoculum will spread and its resistance plasmids will be exchanged with the non-resistant bacteria (and, dare I say, emerge:). Granted, if there is a selective pressure (the use of the antibiotic to which the resistant bacteria is resistant), that spread will happen a lot faster, but it will still happen to some extent even without the selection. Also, even a small number ...
https://freethoughtblogs.com/pharyngula/2007/02/21/whats-the-matter-with-mds/
Examiner PhD Production and characterization of Bacteriocins from Lactic acid bacteria University of Agriculture, PK -...Examiner PhD Production and characterization of Bacteriocins from Lactic acid bacteria University of Agriculture, PK -...
Powered by Pure, Scopus & Elsevier Fingerprint Engine™ © 2021 Elsevier B.V. We use cookies to help provide and enhance our service and tailor content. By continuing you agree to the use of cookies. ...
https://pure.ulster.ac.uk/en/activities/examiner-phd-production-and-characterization-of-bacteriocins-from
Activation of the expression of the microcin C51 operon upon glucose starvation of cells at the exponential growth phase,...Activation of the expression of the microcin C51 operon upon glucose starvation of cells at the exponential growth phase,...
Read Activation of the expression of the microcin C51 operon upon glucose starvation of cells at the exponential growth phase, Russian Journal of Genetics on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
https://www.deepdyve.com/lp/springer_journal/activation-of-the-expression-of-the-microcin-c51-operon-upon-glucose-HSmknuPnYj
Properties of the Functioning of the Promoter of the Microcin C51 Operon under Different Conditions of Escherichia coliCell...Properties of the Functioning of the Promoter of the Microcin C51 Operon under Different Conditions of Escherichia coliCell...
Read Properties of the Functioning of the Promoter of the Microcin C51 Operon under Different Conditions of Escherichia coliCell Growth, Russian Journal of Genetics on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
https://www.deepdyve.com/lp/springer_journal/properties-of-the-functioning-of-the-promoter-of-the-microcin-c51-qwmqIzcEk8
American Institute of Mathematical SciencesAmerican Institute of Mathematical Sciences
In this paper we analyze the population dynamics of bacteria competing by anti-bacterial toxins (bacteriocins). Three types of bacteria involved in these dynamics can be distinguished: toxin producers, resistant bacteria and sensitive bacteria. Their interplay can be regarded as a Rock-Scissors-Paper - game (RSP). Here, this is modeled by a reasonable three-dimensional Lotka- Volterra ($L$V) type differential equation system. In contrast to earlier approaches to modeling the RSP game such as replicator equations, all interaction terms have negative signs because the interaction between the three different types of bacteria is purely competitive, either by toxification or by competition for nutrients. The model allows one to choose asymmetric parameter values. Depending on parameter values, our model gives rise to a stable steady state, a stable limit cycle or a heteroclinic orbit with three fixed points, each fixed point corresponding to the existence of only one bacteria type. An alternative ...
http://aimsciences.org/journal/1531-3492/2007/8/1
Background Lantibiotics are lanthionine-containing, post-translationally modified antimicrobial peptides. thermodenitrificans...
Background Lantibiotics are lanthionine-containing, post-translationally modified antimicrobial peptides. thermodenitrificans NG80-2 and Geobacillus sp. G11MC16 have become conserved extremely. Both LanAs are 100% similar as well as the homology between these, as well as the connected B and Cs certainly, and the related G. kaustophilus HTA426 protein over is certainly discussed. It was mentioned how the lanB of Geobacillus sp. G11MC16 can be evidently frameshifted (G11MC16DRAFT_2955 (176aa) and G11MC16DRAFT_2954 (848aa)) but that is not the situation in G. thermodenitrificans NG80-2 (GTNG_0266). Recognition of book Staphylococcus-connected lantibiotic gene clustersThe staphylococci are non-sporeforming, nonmotile Firmicutes. The genus Staphylococcus consists of 33 species, many of that are live and safe normally about your skin and mucous membranes of human beings and additional organisms. However, staphylococci may also result in a wide selection of illnesses either through toxin creation or ...
http://biodigestor.net/?p=2122
Pharmaceuticals | Free Full-Text | Lysostaphin: A Staphylococcal Bacteriolysin with Potential Clinical ApplicationsPharmaceuticals | Free Full-Text | Lysostaphin: A Staphylococcal Bacteriolysin with Potential Clinical Applications
Lysostaphin is an antimicrobial agent belonging to a major class of antimicrobial peptides and proteins known as the bacteriocins. Bacteriocins are bacterial antimicrobial peptides which generally exhibit bactericidal activity against other bacteria. Bacteriocin production is a self-protection mechanism that helps the microorganisms to survive in their natural habitats. Bacteriocins are currently distributed into three main classes. Staphylococcins are bacteriocins produced by staphylococci, which are Gram-positive bacteria of medical and veterinary importance. Lysostaphin is the only class III staphylococcin described so far. It exhibits a high degree of antistaphylococcal bacteriolytic activity, being inactive against bacteria of all other genera. Infections caused by staphylococci continue to be a problem worldwide not only in healthcare environments but also in the community, requiring effective measures for controlling their spread. Since lysostaphin kills human and animal staphylococcal pathogens,
http://www.mdpi.com/1424-8247/3/4/1139
The synergistic antibacterial effect of bacteriocin produced by Lactobacillus casei ATCC 39392 and iron oxide nanoparticles ...The synergistic antibacterial effect of bacteriocin produced by Lactobacillus casei ATCC 39392 and iron oxide nanoparticles ...
Bacteriocins are antimicrobial proteins, which show antagonistic effects on pathogenic bacteria. The most important problems of bacteriocins are low stability and specific antibacterial activities. Using the antibacterial activity of nanoparticles in combination with bacteriocins is a new strategy against pathogenic bacteria. This study aimed to investigate the combined effects of iron oxide nanoparticles (IONPs) and bacteriocins produced by Lactobacillus casei ATCC 39392 against selected foodborne pathogens. Iron oxide nanoparticles (IONPs) were synthesized by hydrothermal method and characterized using a field-emission scanning electron microscope, transmission electron microscope, and dynamic light scattering analysis. Minimum inhibitory concentration and antibacterial activity of bacteriocins produced by L. casei ATCC 39392 alone, and in the combination of (IONPs) evaluated against selected foodborne pathogens including; Listeria monocytogenes PTCC1294, Bacillus cereus PTCC1857, Staphylococcus
http://www.ijmcm.ir/article_678910.html
Bacteriocinogenic plasmids | definition of bacteriocinogenic plasmids by Medical dictionaryBacteriocinogenic plasmids | definition of bacteriocinogenic plasmids by Medical dictionary
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http://medical-dictionary.thefreedictionary.com/bacteriocinogenic+plasmids
The unusual BLIS activities of Streptococcus salivarius strain PirieThe unusual BLIS activities of Streptococcus salivarius strain Pirie
Most streptococcal species are essentially non-pathogenic and are part of the normal commensal microflora of the mouth, skin, intestine, and upper respiratory tract of humans (and other animals). Streptococcus salivarius is a predominant oral streptococcal species in humans that is thought to play an important role in the maintenance of a healthy oral microbial ecosystem. A notable characteristic of this species is that they commonly produce Bacteriocin-like Inhibitory Substances (BLIS). Streptococcus salivarius strain Pirie resembles strain K12, the prototype BLIS-producing S. salivarius, in that it inhibits all nine standard indicators when tested in a streptococcal bacteriocin fingerprinting scheme. Another similarity to strain K12 is the presence of the class I bacteriocins salivaricin A genes in strain Pirie. However, strain Pirie differs from strain K12 in having a broader spectrum of inhibitory activity against other members of the commensal oral microflora, including most strains of S. ...
https://ourarchive.otago.ac.nz/handle/10523/3874
Identification, Purification and Characterization of Laterosporulin, a Novel Bacteriocin Produced by Brevibacillus sp. Strain...Identification, Purification and Characterization of Laterosporulin, a Novel Bacteriocin Produced by Brevibacillus sp. Strain...
Background Bacteriocins are antimicrobial peptides that are produced by bacteria as a defense mechanism in complex environments. Identification and characterization of novel bacteriocins in novel strains of bacteria is one of the important fields in bacteriology. Methodology/Findings The strain GI-9 was identified as Brevibacillus sp. by 16 S rRNA gene sequence analysis. The bacteriocin produced by strain GI-9, namely, laterosporulin was purified from supernatant of the culture grown under optimal conditions using hydrophobic interaction chromatography and reverse-phase HPLC. The bacteriocin was active against a wide range of Gram-positive and Gram-negative bacteria. MALDI-TOF experiments determined the precise molecular mass of the peptide to be of 5.6 kDa and N-terminal sequencing of the thermo-stable peptide revealed low similarity with existing antimicrobial peptides. The putative open reading frame (ORF) encoding laterosporulin and its surrounding genomic region was fished out from the draft
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0031498
Chimeras of mature pediocin PA-1 fused to the signal peptide of enterocin P permits the cloning, production, and expression of...Chimeras of mature pediocin PA-1 fused to the signal peptide of enterocin P permits the cloning, production, and expression of...
Chimeras of pediocin PA-1 (PedA-1), a bacteriocin produced by Pediococcus acidilactici PLBH9, fused to the signal peptide of enterocin P (EntP), a sec-dependent bacteriocin produced by Enterococcus faecium P13, permitted the production of PedA-1 in Lactococcus lactis. Chimeric genes encoding the EntP signal peptide (SP(entP)) fused to mature PedA-1 (pedA), with or without its immunity gene (pedB), were cloned into the expression vector pMG36c to generate the recombinant plasmids pMPP9 (SP(entP):pedA) and pMPP14i (SP(entP):pedA + pedB). Transformation of competent L. lactis subsp. lactis IL1403, L. lactis subsp. cremoris NZ9000, and L. lactis subsp. lactis DPC5598 with the recombinant plasmids has permitted the detection and quantitation of PedA-1 and the coproduction of nisin A and PedA-1 in supernatants of producer cells with specific anti-PedA-1 antibodies and a noncompetitive indirect enzyme-linked immunosorbent assay. Recombinant L. lactis hosts carrying pMPP9 or pMPP14i displayed ...
http://epubs.surrey.ac.uk/826010/
Biomolecules | Free Full-Text | A Microplate Growth Inhibition Assay for Screening Bacteriocins against Listeria monocytogenes...Biomolecules | Free Full-Text | A Microplate Growth Inhibition Assay for Screening Bacteriocins against Listeria monocytogenes...
Lactic acid bacteria (LAB) have historically been used in food fermentations to preserve foods and are generally-recognized-as-safe (GRAS) by the FDA for use as food ingredients. In addition to lactic acid; some strains also produce bacteriocins that have been proposed for use as food preservatives. In this study we examined the inhibition of Listeria monocytogenes 39-2 by neutralized and non-neutralized bacteriocin preparations (Bac+ preps) produced by Lactobacillus curvatus FS47; Lb. curvatus Beef3; Pediococcus acidilactici Bac3; Lactococcus lactis FLS1; Enterococcus faecium FS56-1; and Enterococcus thailandicus FS92. Activity differences between non-neutralized and neutralized Bac+ preps in agar spot assays could not readily be attributed to acid because a bacteriocin-negative control strain was not inhibitory to Listeria in these assays. When neutralized and non-neutralized Bac+ preps were used in microplate growth inhibition assays against L. monocytogenes 39-2 we observed some differences
http://www.mdpi.com/2218-273X/5/2/1178
Determinants encoding fimbriae type 1 in fecal Escherichia coli are associated with increased frequency of bacteriocinogeny |...Determinants encoding fimbriae type 1 in fecal Escherichia coli are associated with increased frequency of bacteriocinogeny |...
To screen whether E. coli strains encoding type 1 fimbriae, isolated from fecal microflora, produce bacteriocins more often relative to fimA-negative E. coli strains of similar origin. PCR assays were used to detect presence of genes encoding 30 bacteriocin determinants (23 colicin- and 7 microcin-encoding genes) and 18 virulence determinants in 579 E. coli strains of human and animal origin isolated from hospitals and animal facilities in the Czech and Slovak Republic. E. coli strains were also classified into phylogroups (A, B1, B2 and D). fimA-negative E. coli strains (defined as those possessing none of the 18 tested virulence determinants) were compared to fimA-positive E. coli strains (possessing fimA as the only detected virulence determinant). Strains with identified bacteriocin genes were more commonly found among fimA-positive E. coli strains (35.6 %) compared to fimA-negative E. coli strains (21.9 %, p | 0.01) and this was true for both colicin and microcin
https://bmcmicrobiol.biomedcentral.com/articles/10.1186/s12866-015-0530-5
Lantibiotics | definition of Lantibiotics by Medical dictionaryLantibiotics | definition of Lantibiotics by Medical dictionary
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https://medical-dictionary.thefreedictionary.com/Lantibiotics
AbstractAbstract
Author: Pooja Rani, Navreet Kaur Saini, Anjali Gagneja, Manpreet Kaur. Category: [Download PDF]. Abstract:. Bacteriocins are antimicrobial metabolites produced by lactic acid bacteria, which are being used as additives to prevent microbial spoilage of food items. Bacteriocins in free form are degraded by the enzymes present in the fruit juices. Encapsulation matrix protects the bacteriocin from food components. The present study was designed to elucidate the effectiveness of calcium alginate entrapped bacteriocin of Lactobacillus acidophilus in preservation of fruit juices. Calcium alginate gel was chosen as immobilization matrix because it is cheap, abundant and bio safe. Bacteriocin of Lactobacillus acidophilus NCDC 343 showed wide spectrum of antimicrobial activity against pathogenic and food spoilage microorganisms. It inhibited the growth of Staphylococcus aureus, Erwinia sp., Bacillus subtilis, Pseudomonas fluorescens, Leuconostoc mesenteroids and Listeria monocytogenes. Immobilized ...
http://emergentresearch.org/abstract.php?article_id=1805
Biosynthesis and Transport of the Lantibiotic Mutacin 1140 Produced by Streptococcus mutansBiosynthesis and Transport of the Lantibiotic Mutacin 1140 Produced by Streptococcus mutans
Escano, Jerome; Stauffer, Byron; Brennan, Jacob; Bullock, Monica; Smith, Leif (2015). Biosynthesis and Transport of the Lantibiotic Mutacin 1140 Produced by Streptococcus mutans. Journal of Bacteriology. Available electronically from http : / /hdl .handle .net /1969 .1 /183340. ...
https://oaktrust.library.tamu.edu/handle/1969.1/183340
EMDB-20648: CryoEM Structure of Pyocin R2 - postcontracted - baseplate - YorodumiEMDB-20648: CryoEM Structure of Pyocin R2 - postcontracted - baseplate - Yorodumi
R-type bacteriocins are minimal contractile nanomachines that hold promise as precision antibiotics. Each bactericidal complex uses a collar to bridge a hollow tube with a contractile sheath loaded in a metastable state by a baseplate scaffold. Fine-tuning of such nucleic acid-free protein machines for precision medicine calls for an atomic description of the entire complex and contraction mechanism, which is not available from baseplate structures of the (DNA-containing) T4 bacteriophage. Here we report the atomic model of the complete R2 pyocin in its pre-contraction and post-contraction states, each containing 384 subunits of 11 unique atomic models of 10 gene products. Comparison of these structures suggests the following sequence of events during pyocin contraction: tail fibres trigger lateral dissociation of baseplate triplexes; the dissociation then initiates a cascade of events leading to sheath contraction; and this contraction converts chemical energy into mechanical force to drive the ...
https://pdbj.org/emnavi/quick.php?id=emdb-20648
Pediocins: The bacteriocins of Pediococci. Sources, production, properties and applications | Microbial Cell Factories | Full...Pediocins: The bacteriocins of Pediococci. Sources, production, properties and applications | Microbial Cell Factories | Full...
In general, pediocin production displays primary metabolite kinetics with the rate of production paralleled the growth rate [5, 36, 56, 58, 74-76]. Pediocin AcH from P. acidilactici H, was detected in the fermentation broth in much higher amounts after the culture pH had reached 4.0 and growth entered the late exponential phase. Even after the cells had reached the stationary phase (18 hours), considerable amounts of pediocin were produced [5]. Anastasiadou et al. [36] presented kinetic studies of production of pediocin SA-1 from P. acidilactici and pediocin SM-1 from P. pentosaceus [56] at different dissolved oxygen levels. Under semi aerobic conditions, that supported the highest specific pediocin production rates, specific production rates followed the specific growth rates and production of both pediocins followed the trend of biomass production. In both cases, production ceased once the stationary phase of growth was reached. Maximum pediocin SA-1 levels were detected at 14 hours (160 ...
https://microbialcellfactories.biomedcentral.com/articles/10.1186/1475-2859-8-3
Isolation and Partial Characterization of the Streptococcus Mutans Type AII Lantibiotic Mutacin K8 - PubMedIsolation and Partial Characterization of the Streptococcus Mutans Type AII Lantibiotic Mutacin K8 - PubMed
Streptococcus mutans strain K8 was shown to produce a newly identified type AII lantibiotic, mutacin K8. The mutacin K8-encoding muk locus consists of 13 ORFs, three of which (mukA1, A2 and A3) have close homology to scnA, the structural gene encoding the Streptococcus pyogenes lantibiotic SA-FF22, …
https://pubmed.ncbi.nlm.nih.gov/17464078/
Effect of Bacteriocins (from Bifidobacterium Spp.)on Prevalence of some Aeromonas and Pseudomonas Species in Minced Meat during...Effect of Bacteriocins (from Bifidobacterium Spp.)on Prevalence of some Aeromonas and Pseudomonas Species in Minced Meat during...
Effect of Bacteriocins (from Bifidobacterium Spp) on Prevalence of some Aeromonas and Pseudomonas Species in Minced Meat during Cold Storage The effect of bifidin (1.6%)..
https://www.scitechnol.com/peer-review/effect-of-bacteriocins-from-bifidobacterium-sppon-prevalence-of-some-aeromonas-and-pseudomonas-species-in-minced-meat-during-cold--JSi4.php?article_id=4479
Evolutionary genomics of Staphylococcus aureus: Insights into the origin of methicillin-resistant strains and the toxic shock...Evolutionary genomics of Staphylococcus aureus: Insights into the origin of methicillin-resistant strains and the toxic shock...
RD1 (≈40 kb; 35 ORFs) has several noteworthy features, including a cluster of six genes encoding serine protease homologues with 49-93% identity to each other, a group of 8 genes encoding proteins involved in bacteriocin production and resistance, contiguous genes for leukotoxins D and E, and genes encoding proteins with 49% amino acid identity to restriction modification type Ic proteins made by Streptococcus thermophilus. The bacteriocin genes were present in 9 of 36 strains analyzed, and the genes for leukotoxins D and E were present in 17 strains. The entire serine protease gene cluster was absent in three strains. RD1 was highly variable in gene content among the 36 strains examined, with 5 major variants identified.. RD2 (≈50 kb; 50 ORFs) is the staphylococcal chromosomal cassette mec (SCCmec) and was present only in MRSA strains. There was considerable variation in the gene content of RD2 among the 11 MRSA strains (Fig. 3). However, all MRSA strains had 13 of the ORFs present in RD2 ...
https://www.pnas.org/content/98/15/8821?ijkey=71b7c2ddceed8ab0db61246edf74c482b0a60aad&keytype2=tf_ipsecsha
Collaborations :: Oragenics, Inc. (OGEN)Collaborations :: Oragenics, Inc. (OGEN)
Our ECC with Intrexon grants us access to use their advanced transgene and cell engineering platforms for the development and production of lantibiotics, a class of peptide antibiotics that are naturally produced in Gram-positive bacteria and contain the characteristic polycyclic thioether amino acids lanthionine and methyllanthonine (collectively, the Lantibiotics Program).. View ECC - Lantibiotics ». ...
https://www.oragenics.com/collaborations
Maturation of the Translation Inhibitor Microcin C | Journal of BacteriologyMaturation of the Translation Inhibitor Microcin C | Journal of Bacteriology
FIG. 4. The aminopropyl group increases the efficiency of AspRS inhibition by processed McC. (A) E. coli S30 extracts were incubated in the presence of different concentrations of McC or the McC derivative lacking the aminopropyl group for a time period sufficient for complete processing. Next, the tRNAAsp aminoacylation reaction was carried out. The amounts of aminoacylated tRNAAsp (measured by determining the incorporation of [C14]Asp in trichloroacetic acid-precipitable material) are shown. See reference 10 for experimental details. The curves are representative of curves obtained in three independent experiments. (B) Structural modeling of the interaction of processed McC with E. coli AspRS: surface representation of E. coli AspRS (PDB code 1c0a) (4) residues within 10 Å of bound aspartyl-AMP and modeled processed McC (both shown using ball-and-stick representation). Distances between the modeled position of the propylamine nitrogen atom and side chain oxygen atoms of Glu482 and Asp475 are ...
https://jb.asm.org/content/191/7/2380/figures-only
What will be the future antibiotics | ORDO NEWSWhat will be the future antibiotics | ORDO NEWS
ORDO NEWS) - Scientists from the Institute of Bioorganic Chemistry. MM Shemyakina and Yu. A. Ovchinnikov of the Russian Academy of Sciences, MIPT and HSE studied the interaction of a known natural antibiotic with its target using molecular modeling. These data will help to develop effective new types of antibiotics.. The overuse of antibiotics leads to the rapid development of bacterial resistance, which poses a threat to human health around the world. Therefore, the search and development of new classes of antibacterial agents with a mode of action that is not used today is extremely relevant. In microbiology, small antimicrobial proteins called lantibiotics are known to have bactericidal potential.. Nisin, the best studied lantibiotic, was discovered even before Alexander Flemings discovery of penicillin. Nisin has never been used in clinical practice due to instability in the human body. However, it has been widely used as a food preservative since 1953 without any signs of developing ...
https://ordonews.com/what-will-be-the-future-antibiotics/
Fighting biofilms with lantibiotics and other groups of bacteriocinsFighting biofilms with lantibiotics and other groups of bacteriocins
Biofilms are sessile communities of bacteria typically embedded in an extracellular polymeric matrix. Bacterial cells embedded in biofilms are inherently recalcitrant to antimicrobials, compared to cells existing in a planktonic state, and are notoriously difficult to eradicate once formed. Avenues to tackle biofilms thus far have largely focussed on attempting to disrupt the initial stages of biofilm formation, including adhesion and maturation of the biofilm. Such an approach is advantageous as the concentrations required to inhibit formation of biofilms are generally much lower than removing a fully established biofilm. The crisis of antibiotic resistance in clinical settings worldwide has been further exacerbated by the ability of certain pathogenic bacteria to form biofilms. Perhaps the most notorious biofilm formers described from a clinical viewpoint have been methicillin-resistant Staphylococcus aureus (MRSA), Staphylococcus epidermidis, Pseudomonas aeruginosa, Gardnerella vaginalis and ...
https://cora.ucc.ie/handle/10468/6723
Selection and Characterization of Bacteriocin-Producing Lactobacillus sp. AP 116 from the Intestine of Pig for Potential...Selection and Characterization of Bacteriocin-Producing Lactobacillus sp. AP 116 from the Intestine of Pig for Potential...
Selection and Characterization of Bacteriocin-Producing Lactobacillus sp. AP 116 from the Intestine of Pig for Potential Probiotics - antimicrobial activity;bacteriocin;probiotics;alternatives;Lactobacillus;
http://www.koreascience.or.kr/article/ArticleFullRecord.jsp?cn=CSSPBQ_2012_v32n1_31
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Structural Basis for Type VI Secretion Effector Recognition by a Cognate Immunity ProteinStructural Basis for Type VI Secretion Effector Recognition by a Cognate Immunity Protein
The type VI secretion system (T6SS) has emerged as an important mediator of interbacterial interactions. A T6SS from Pseudomonas aeruginosa targets at least three effector proteins, \(\underline t\)ype VI \(\underline s\)ecretion \(\underline e\)xported 1-3 (Tse1-3), to recipient Gram-negative cells. The Tse2 protein is a cytoplasmic effector that acts as a potent inhibitor of target cell proliferation, thus providing a pronounced fitness advantage for P. aeruginosa donor cells. P. aeruginosa utilizes a dedicated immunity protein, \(\underline t\)ype VI \(\underline s\)ecretion \(\underline i\)mmunity 2 (Tsi2), to protect against endogenous and intercellularly-transferred Tse2. Here we show that Tse2 delivered by the T6SS efficiently induces quiescence, not death, within recipient cells. We demonstrate that despite direct interaction of Tsi2 and Tse2 in the cytoplasm, Tsi2 is dispensable for targeting the toxin to the secretory apparatus. To gain insights into the molecular basis of Tse2 ...
https://dash.harvard.edu/handle/1/10121033
Nucleotide polymorphism in microcin V plasmids. | Riley LabNucleotide polymorphism in microcin V plasmids. | Riley Lab
DNA sequence polymorphism was determined for the microcin V gene cluster encoded on the microcin V plasmids of 12 natural isolates of Escherichia coli. These microcin V gene clusters are similar in DNA sequence, with only 10 of the 683 bp polymorphic. Further, the levels and patterns of microcin V gene cluster polymorphism differ from those of a chromosomal region, trpORF2, sequenced from each of the host isolates. These contrasting levels and patterns of polymorphism suggest that the microcin V gene cluster has experienced an evolutionary history different from that of the host ...
http://www.bio.umass.edu/biology/riley/node/173
A sub-population of group A Streptococcus elicits a population-wide production of bacteriocins to establish dominance in the...A sub-population of group A Streptococcus elicits a population-wide production of bacteriocins to establish dominance in the...
By downloading, copying, or making any use of the images located on this website (Site) you acknowledge that you have read and understand, and agree to, the terms of this Image Usage Agreement, as well as the terms provided on the Legal Notices webpage, which together govern your use of the images as provided below. If you do not agree to such terms, do not download, copy or use the images in any way, unless you have written permission signed by an authorized Pacific Biosciences representative.. Subject to the terms of this Agreement and the terms provided on the Legal Notices webpage (to the extent they do not conflict with the terms of this Agreement), you may use the images on the Site solely for (a) editorial use by press and/or industry analysts, (b) in connection with a normal, peer-reviewed, scientific publication, book or presentation, or the like. You may not alter or modify any image, in whole or in part, for any reason. You may not use any image in a manner that misrepresents the ...
https://www.pacb.com/publications/a-sub-population-of-group-a-streptococcus-elicits-a-population-wide-production-of-bacteriocins-to-establish-dominance-in-the-host/
Results for cd07474Results for cd07474
Peptidase S8 family domain in Vpr-like proteins. The maturation of the peptide antibiotic (lantibiotic) subtilin in Bacillus subtilis ATCC 6633 includes posttranslational modifications of the propeptide and proteolytic cleavage of the leader peptide. Vpr was identified as one of the proteases, along with WprA, that are capable of processing subtilin. Asp, Ser, His triadPeptidases S8 or Subtilases are a serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values. ...
http://bioinf.umbc.edu/DMDM/generatelogo.php?domain=Peptidases_S8_subtil&accession=cd07474&prot=13124785
TIGR03740TIGR03740
Model TIGR03731 represents the family of all lantibiotics related to gallidermin, including epidermin, mutatin, and nisin. This protein family describes the ATP-binding subunit of a gallidermin/epidermin class lantibiotic protection transporter. It is largely restricted to gallidermin-family lantibiotic biosynthesis and export cassettes, but also occurs in orphan transporter cassettes in species that lack candidate lantibiotic precursor and synthetase genes ...
http://www.jcvi.org/cgi-bin/tigrfams/HmmReportPage.cgi?acc=TIGR03740
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AID 1307019 - Potency index, ratio of chloromycin MIC to compound MIC for Bacillus subtilis ATCC6633 - PubChemAID 1307019 - Potency index, ratio of chloromycin MIC to compound MIC for Bacillus subtilis ATCC6633 - PubChem
BioAssay record AID 1307019 submitted by ChEMBL: Potency index, ratio of chloromycin MIC to compound MIC for Bacillus subtilis ATCC6633.
https://pubchem.ncbi.nlm.nih.gov/bioassay/1307019
Remediated Sequence - 3ZG4: NMR structure of the catalytic domain from E. faecium L,D- transpeptidase Sequence Report...Remediated Sequence - 3ZG4: NMR structure of the catalytic domain from E. faecium L,D- transpeptidase Sequence Report...
3ZG4: The Structure of Enterococcus Faecium L,D---Transpeptidase Acylated by Ertapenem Provides Insight Into the Inactivation Mechanism.
http://www.rcsb.org/pdb/explore/remediatedSequence.do?structureId=3ZG4
Ιατρικά Άρθρα Αλέξανδρος Γ. Σφακιανάκης: Cerebrospinal Fluid Levels of 14-3-3 Gamma: What Does It Tell Us About Sporadic...
Clinical diagnosis of Creutzfeldt-Jakob disease (CJD) can be supported by the analysis of Tau and 14-3-3 in the cerebrospinal fluid (CSF). In this short report, we report about a retrospective analysis performed on 2,296 routinely collected CSF samples, and 44 samples with a ratio of phosphoTau181/Tau 100,000 AU/mL, while 10 out of 12 suspected CJD samples with 14-3-3 CSF levels between 50,000-100,000 AU/mL were CJD positive. All samples with 14-3-3 levels between 15,000 and 50,000 AU/mL were not CJD cases but disorders with complex neuropathology. In conclusion, our data suggests that in CSF samples with a phospho-Tau-181/Tau ratio Pharmacology 2017;100:243- ...
http://iatrikisfakianakis.blogspot.com/2017/07/cerebrospinal-fluid-levels-of-14-3-3.html
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pldA - Phospholipase A1 precursor - Escherichia coli (strain K12) - pldA gene & proteinpldA - Phospholipase A1 precursor - Escherichia coli (strain K12) - pldA gene & protein
Has broad substrate specificity including hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities. Strong expression leads to outer membrane breakdown and cell death; is dormant in normal growing cells. Required for efficient secretion of bacteriocins.
https://www.uniprot.org/uniprot/P0A921
Slow Release vs Fast Release Protein - MrSupplement.com.auSlow Release vs Fast Release Protein - MrSupplement.com.au
Learn more about the evolution of fast and slow protein supplements and how they differentially affect muscle protein synthesis and breakdown...
https://www.mrsupplement.com.au/slow-release-vs-fast-release-protein
BUY TINACTIN LIQUID AEROSOL 0.72MG/GM BCN FARMA, S.L PRICE & SIDE EFFECTSBUY TINACTIN LIQUID AEROSOL 0.72MG/GM BCN FARMA, S.L PRICE & SIDE EFFECTS
Using TINACTIN LIQUID AEROSOL 0.72MG/GM during pregnancy may raise the risk of children developing some disorder (commpon for some such kind of drugs), however it depends upon how TINACTIN LIQUID AEROSOL 0.72MG/GM ingredients pass through placenta and may have effect on baby - Strength of TINACTIN LIQUID AEROSOL 0.72MG/GM is major factor in determination of such side effects, The possible danger in pregnancy are under research. BCN FARMA, S.L Canada publish leaflet about TINACTIN LIQUID AEROSOL 0.72MG/GM every update to describe possible risks of using TINACTIN LIQUID AEROSOL 0.72MG/GM side effect in pregnancy and pregnant women. You may download BCN FARMA, S.L issued leaflet regarding side effects of TINACTIN LIQUID AEROSOL 0.72MG/GM - TOLNAFTATE. Pregnancy Side Effects can be easily know by Atc code of TINACTIN LIQUID AEROSOL 0.72MG/GM ATC CODE.. ...
http://buymedicinesx.com/buy-tinactin-liquid-aerosol-0-72mggm-price-side-effects-atc/
ارزیابی بررسی اثرات مکمل نوکلئوتیدی جیره و پروبیوتیک پدیوکوکوس اسیدی لاکتیکی بر شاخص های رشد، بیوشیمیایی و ایمنی سرم خون و...
این تحقیق با هدف بررسی اثرات مکمل نوکلوتیدی جیره و پروبیوتیک P. acidilactici بر عملکرد رشد، برخی از شاخص- های ایمنی و بیوشیمیایی سرم خون، و همچنین مقاومت در برابر باکتری آئروموناس هیدروفیلا در ماهی قزل آلای رنگین کمان انجام گرفت. نه تیمار غذایی حاوی سه سطح از مکمل نوکلوتیدی (0، 1 و 3 گرم بر کیلوگرم غذا) و سه سطح از P. acidilactici (0 و 1، 3 گرم بر کیلوگرم غذا) بر اساس طرح فاکتوریل 3×3 طراحی شد. هر یک از جیره- ها به طور تصادفی برای سه گروه (تکرار) 30 تایی از ماهی- های قزل آلای رنگین کمان (با میانگین وزن اولیه 1/62±63/4 گرم) در نظر گرفته شد. در پایان دوره هشت هفته -ای آزمایش، برخی از شاخص- های
https://journal.ut.ac.ir/article_63827.html
A Comparison of Reversible Versus Irreversible Protein Glutathionylati by Danyelle M. Townsend, Volodymyr I. Lushchak et al.A Comparison of Reversible Versus Irreversible Protein Glutathionylati by Danyelle M. Townsend, Volodymyr I. Lushchak et al.
Glutathionylation is generally a reversible posttranslational modification that occurs to cysteine residues that have been exposed to reactive oxygen species (P-SSG). This cyclical process can regulate various clusters of proteins, including those involved in critical cellular signaling functions. However, certain conditions can favor the formation of dehydroamino acids, such as 2,3-didehydroalanine (2,3-dehydroalanine, DHA) and 2,3-didehydrobutyrine (2,3-dehydrobutyrine), which can act as Michael acceptors. In turn, these can form Michael adducts with glutathione (GSH), resulting in the formation of a stable thioether conjugate, an irreversible process referred to as nonreducible glutathionylation. This is predicted to be prevalent in nature, particularly in more slowly turning over proteins. Such nonreducible glutathionylation can be distinguished from the more facile cycling signaling processes and is predicted to be of gerontological, toxicological, pharmacological, and oncological relevance. Here,
https://touroscholar.touro.edu/nymc_fac_pubs/51/
TCDB » SEARCHTCDB » SEARCH
9.B.81 The MceB Immunity Protein (MceB) Family. The MceB protein of Klebsiella pneumoniae protects the cells against the toxic endogenous MceE protein, the precursor of microcin E492, and against this exogenous microcin (Bieler et al., 2006; Lagos et al., 1999; 2001). Its mechanism of action is not known, but it is a cytoplasmic membrane protein with three putative TMSs. ...
http://tcdb.org/search/result.php?tc=9.B.81
BacteriocinBacteriocin
Colicins are bacteriocins found in the Gram-negative E. coli. Similar bacteriocins (CLBs, colicin-like bacteriocins) occur in ... Wikimedia Commons has media related to Bacteriocin. Bagel Bacteriocin Database BACTIBASE Database Bacteriocins at the US ... They are the longest studied bacteriocins. They are a diverse group of bacteriocins and do not include all the bacteriocins ... The class I bacteriocins are small peptide inhibitors and include nisin and other lantibiotics. The class II bacteriocins are ...
https://en.wikipedia.org/wiki/Bacteriocin
Bacteriocin IIdBacteriocin IId
... though it lacks sequence homology with bacteriocins AS-48. Bacteriocin uses components of the mannose phosphotransferase system ... Bacteriocin AS-48 is encoded by the pheromone-responsive plasmid pMB2, and acts on the plasma membrane in which it opens pores ... Bacteriocin AS-48 is a cyclic peptide antibiotic produced by the eubacteria Enterococcus faecalis (Streptococcus faecalis) that ... González C, Langdon GM, Bruix M, Gálvez A, Valdivia E, Maqueda M, Rico M (October 2000). "Bacteriocin AS-48, a microbial cyclic ...
https://en.wikipedia.org/wiki/Bacteriocin_IId
Class II bacteriocinClass II bacteriocin
Bacteriocins for which disulfide bonds are the only modification to the peptide are Class II bacteriocins. One important and ... The class IIb bacteriocins (two-peptide bacteriocins) require two different peptides for activity. It includes the alpha ... Bacteriocin AS-48 is encoded by the pheromone-responsive plasmid pMB2, and acts on the plasma membrane in which it opens pores ... Class II bacteriocins are a class of small peptides that inhibit the growth of various bacteria. Many Gram-positive bacteria ...
https://en.wikipedia.org/wiki/Class_II_bacteriocin
HalocinHalocin
... s are bacteriocins produced by halophilic Archaea and a type of archaeocin. Since their discovery in 1982, halocins have ... Like other bacteriocins, the halocins are under investigation as antimicrobials for use in controlling spoilage during ... BACTIBASE database is an open-access database for bacteriocins including halocins (view complete list). Li Y, Xiang H, Tan H ( ... Halocins are particularly interesting because of the way the pore-forming bacteriocins have been used to probe cell membrane ...
https://en.wikipedia.org/wiki/Halocin
SakacinSakacin
... s are bacteriocins produced by Lactobacillus sakei. They are often clustered with the other lactic acid bacteriocins. ... Sakacin T is a class II bacteriocin. It is produced from a single operon with sakacin X; there are three distinct promoters in ... Sakacin T Sakacin X is a class IIa bacteriocin. It appears in the references with Sakacin T (above). Sakacin Z was apparently ... Diep DB, Axelsson L, Grefsli C, Nes IF (2000). "The synthesis of the bacteriocin sakacin A is a temperature-sensitive process ...
https://en.wikipedia.org/wiki/Sakacin
BisinBisin
Lantibiotics, Food preservation, Peptides, Bacteriocins). ...
https://en.wikipedia.org/wiki/Bisin
Bokashi (horticulture)Bokashi (horticulture)
De Vuyst, L.; Vandamme, E.J. (1994). "Antimicrobial Potential of Lactic Acid Bacteria". Bacteriocins of Lactic Acid Bacteria. ...
https://en.wikipedia.org/wiki/Bokashi_(horticulture)
NisinNisin
... , as a class I bacteriocin, is very stable at acidic pHs and is more heat stable at lower pHs. The mode of action of Nisin ... While in general most bacteriocins inhibit only closely related species, nisin is a rare example of a "broad-spectrum" ... "Bacteriocins and their Food Applications". Comprehensive Reviews in Food Science and Food Safety. 2 (3): 82-100. doi:10.1111/j. ... bacteriocin effective against many Gram-positive organisms, including lactic acid bacteria (commonly associated to avoid food ...
https://en.wikipedia.org/wiki/Nisin
Food packagingFood packaging
... bacteriocins (e.g. nisin, natamycin); and essential oils. In the last decades, the use of modified atmosphere packaging (MAP) ...
https://en.wikipedia.org/wiki/Food_packaging
VibriocinVibriocin
Like other bacteriocins, vibriocins are protein toxins. They can kill bacteria beyond the genus Vibrio, including other ... Vibriocins are a group of bacteriocins produced by, and active against, gram-negative bacteria in the genus Vibrio. They were ... Israil AM, Nacescu N, Ciufecu C, Stefanescu C (1983). "Studies on bacteriocin production by NAG-strains of Vibrio cholerae as a ... Chakrabarty AN, Adhya S, Basu J, Dastidar SJ (1970). "Bacteriocin Typing of Vibrio cholerae". Infection and Immunity. 1 (3): ...
https://en.wikipedia.org/wiki/Vibriocin
Microbial symbiosis and immunityMicrobial symbiosis and immunity
However, bacteriocins can also induce death by translocating into the periplasmic space and cleaving DNA non-specifically ( ... Additionally, bacteriocins are particularly promising due to their difference in mechanisms than antibiotics meaning many ... For example, in vitro growth of methicillin-resistant S. aureus (MRSA) was inhibited by the bacteriocin nisin A, produced by ... Various commensals (primarily Gram-positive bacteria), secrete bacteriocins, peptides which bind to receptors on closely ...
https://en.wikipedia.org/wiki/Microbial_symbiosis_and_immunity
Behavioral ecologyBehavioral ecology
Another example is bacteria that release bacteriocins. The bacteria that releases the bacteriocin may have to die to do so, but ... This is because the ability to produce and release the bacteriocin is linked to an immunity to it. Therefore, close relatives ... most of the harm is to unrelated individuals who are killed by the bacteriocin. ...
https://en.wikipedia.org/wiki/Behavioral_ecology
Food spoilageFood spoilage
"Control of food spoilage molds using lactobacillus bacteriocins". Journal of Pure and Applied Microbiology. 12 (3): 1365-1373. ...
https://en.wikipedia.org/wiki/Food_spoilage
Sylvie Garneau-TsodikovaSylvie Garneau-Tsodikova
Sylvie Garneau; Nathaniel I Martin; John C Vederas (1 May 2002). "Two-peptide bacteriocins produced by lactic acid bacteria". ...
https://en.wikipedia.org/wiki/Sylvie_Garneau-Tsodikova
Pediococcus acidilacticiPediococcus acidilactici
Genetics of bacteriocins produced by lactic acid bacteria. FEMS Microbiol. Rev. 12 :39S-85S Barros R.R., Carvalho G.S., Peralta ... Anti-Listeria effect of enoterocin A, produced by cheese-isolated Enterococcus faecium EFM01, relative to other bacteriocins ... Association of a 13.6-megadalton plasmid in Pediococcus pentosaceus with bacteriocin activity. Appl. Environ. Microbiol. 50: ... primarily through the production of lactic acid and secretion of bacteriocins known as pediocins. P. acidilactici has a wide ...
https://en.wikipedia.org/wiki/Pediococcus_acidilactici
Antibiotic use in livestockAntibiotic use in livestock
Another research team was able to use bacteriocins, antimicrobial peptides and bacteriophages in the control of bacterial ... Joerger R.D. (2003). "Alternatives to antibiotics: bacteriocins, antimicrobial peptides and bacteriophages". Poultry Science. ...
https://en.wikipedia.org/wiki/Antibiotic_use_in_livestock
Lactic acid bacteriaLactic acid bacteria
Nisin, a bacteriocin produced by LAB, was first researched as a food preservative in 1951 and has since been widely ... Some LAB produce bacteriocins which limit pathogens by interfering with cell wall synthesis or causing pore formation in the ... Proteinaceous bacteriocins are produced by several LAB strains and provide an additional hurdle for spoilage and pathogenic ... Delves-Broughton, J.; Blackburn, P.; Evans, R. J.; Hugenholtz, J. (1996). "Applications of the bacteriocin, nisin". Antonie van ...
https://en.wikipedia.org/wiki/Lactic_acid_bacteria
ThiostreptonThiostrepton
Kelly WL, Pan L, Li C (2009). "Thiostrepton biosynthesis: prototype for a new family of bacteriocins". J. Am. Chem. Soc. 131 ( ...
https://en.wikipedia.org/wiki/Thiostrepton
BiopreservationBiopreservation
These days LAB bacteriocins are used as an integral part of hurdle technology. Using them in combination with other ... LAB and their bacteriocins have been consumed unintentionally for ages, laying down a long history of safe use. Their ... Bacteriocins, bacteriophages and bacteriophage-encoded enzymes fall in this theory. The long and traditional role of Lactic ... As a product of its metabolism, it should also produce acids and other antimicrobial agents, particularly bacteriocins. ...
https://en.wikipedia.org/wiki/Biopreservation
Secondary metaboliteSecondary metabolite
Microcins, bacteriocins such as microcin V from Escherichia coli. Thiostrepton, from several strains of streptomycetes, e.g. ...
https://en.wikipedia.org/wiki/Secondary_metabolite
Streptomyces scopuliridisStreptomyces scopuliridis
nov., a bacteriocin-producing soil streptomycete". International Journal of Systematic and Evolutionary Microbiology. 61 (Pt 9 ... nov., a bacteriocin-producing soil streptomycete". International Journal of Systematic and Evolutionary Microbiology. 61 (Pt 9 ... Streptomyces scopuliridis produces bacteriocins, desotamides B, desotamides C, desotamides D, sesquiterpenoids and herbicidins ...
https://en.wikipedia.org/wiki/Streptomyces_scopuliridis
Latilactobacillus sakeiLatilactobacillus sakei
Bacteriocin genes are located either on chromosomes or on plasmids. Strain 5 produces a plasmid-encoded bacteriocin that is ... Sakacins are bacteriocins of class II produced by L. sakei. In strain CCUG 42687, their production is dependent on nutrients, ... The key elements of these vectors are a regulatable promoter involved in the production of the bacteriocins sakacin A and ... Lactocin S is a bacteriocin produced by strain L45 of Lactobacillus sakei. Strain 0-1 of L. sakei produces exopolysaccharides. ...
https://en.wikipedia.org/wiki/Latilactobacillus_sakei
LantibioticsLantibiotics
The lantibiotics are a class of more extensively modified bacteriocins, also called Class I bacteriocins. (Bacteriocins for ... they are considered a member of the bacteriocins. Bacteriocins are classified according to their extent of posttranslational ... Hammami R, Zouhir A, Ben Hamida J, Fliss I (2007). "BACTIBASE: a new web-accessible database for bacteriocin characterization ... BACTIBASE is an open-access database for bacteriocins including lantibiotics. LANTIBASE is a lantibiotic specific resource. ...
https://en.wikipedia.org/wiki/Lantibiotics
Lactobacillus gasseriLactobacillus gasseri
... produces gassericin A, a bacteriocin. Johnson, J. L.; Phelps, C. F.; Cummins, C. S.; London, J.; Gasser, ... 1]Pandey N, Malik RK, Kaushik JK, Singroha G (2013). "Gassericin A: a circular bacteriocin produced by lactic acid bacteria ...
https://en.wikipedia.org/wiki/Lactobacillus_gasseri
Aeromonas mediaAeromonas media
It produces a bacteriocin-like inhibitory substance. Allen, D. A.; Austin, B.; Colwell, R. R. (1983). "Aeromonas media, a New ... Gibson, L.F. (1998). "Bacteriocin activity and probiotic activity of Aeromonas media". Journal of Applied Microbiology. 85 (S1 ...
https://en.wikipedia.org/wiki/Aeromonas_media
Lactobacillus delbrueckii subsp. bulgaricusLactobacillus delbrueckii subsp. bulgaricus
Some strains of L. d. bulgaricus, such as L. bulgaricus GLB44, also produce bacteriocins, which have been shown to kill ... Simova, E. D.; Beshkova, D. M.; Angelov, M. P.; Dimitrov, Z. P. (2008). "Bacteriocin production by strain Lactobacillus ...
https://en.wikipedia.org/wiki/Lactobacillus_delbrueckii_subsp._bulgaricus
PeptidePeptide
Some microbes produce peptides as antibiotics, such as microcins and bacteriocins. Peptides frequently have post-translational ...
https://en.wikipedia.org/wiki/Peptide
MicrocinMicrocin
... s are very small bacteriocins, composed of relatively few amino acids. For this reason, they are distinct from their ... Subtilosin A is another bacteriocin from Bacillus subtilis. The peptide has a cyclized backbone and forms three cross-links ... BACTIBASE database is an open-access database for bacteriocins including microcins. Kawulka KE, Sprules T, Diaper CM, Whittal ... a pore-forming bacteriocin". Cell Discovery. 7 (1): 20. doi:10.1038/s41421-021-00253-6. PMC 8021565. PMID 33820910.{{cite ...
https://en.wikipedia.org/wiki/Microcin
PyocinPyocin
... s are bacteriocins produced by bacteria belonging to the Pseudomonas genus. François Jacob described the first pyocin in ... S-type pyocins are colicin-like bacteriocins as R-type and F-type pyocins belong to tailocins. S-type (soluble) pyocins are ... Articles with short description, Short description is different from Wikidata, Bacteriocins). ...
https://en.wikipedia.org/wiki/Pyocin
Lactobacillus bulgaricus GLB44Lactobacillus bulgaricus GLB44
Miteva V, Stefanova T, Budakov I, Ivanova I, Mitev V, Gancheva A, Ljubenov M (March 1998). "Characterization of bacteriocins ...
https://en.wikipedia.org/wiki/Lactobacillus_bulgaricus_GLB44
BAGEL: a web-based bacteriocin genome mining toolBAGEL: a web-based bacteriocin genome mining tool
This is particularly the case for bacteriocins, a very diverse group of antimicrobial peptides produced by bacteria and usually ... knowledge-based bacteriocin databases and motif databases. Many bacteriocins are encoded by small genes that are often omitted ... BAGEL: a web-based bacteriocin genome mining tool Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W273-9. doi: 10.1093/nar/ ... ORFs surrounding bacteriocin genes are often biosynthetic genes. This information can be used to locate putative structural ...
https://pubmed.ncbi.nlm.nih.gov/16845009/
The role of bacteriocins in shaping oral biofilms | BOB Project | Fact Sheet | H2020 | CORDIS | European CommissionThe role of bacteriocins in shaping oral biofilms | BOB Project | Fact Sheet | H2020 | CORDIS | European Commission
Bacteriocins are antimicrobial peptides produced by bacteria primarily known as... ... the role of bacteriocins in shaping oral biofilms will be investigated by moving a Spanish researcher currently working in ... The role of bacteriocins in biofilm formation. Bacteriocins are a group of antimicrobial peptides produced by bacteria as a ... Moreover, considering that bacteriocins have been suggested as potential alternatives to antibiotics in the future, project ...
https://cordis.europa.eu/project/id/101029099
Antifungal Activity of Bacteriocins of Lactic Acid Bacteria from Some Nigerian Fermented FoodsAntifungal Activity of Bacteriocins of Lactic Acid Bacteria from Some Nigerian Fermented Foods
However, bacteriocins of all the LAB isolates with the exception of Lactobacillus plantarum EK1, L. plantarum EK4 and L. ... Bacteriocin is the most potent of all the antimicrobial compounds produced by Lactic Acid Bacteria (LAB). Bacteriocins are ... The bacteriocins of the LAB strains caused a reduction on the mycelia mass of P. citrinum and the effect of the different LAB ... Antifungal Activity of Bacteriocins of Lactic Acid Bacteria from Some Nigerian Fermented Foods. ...
https://scialert.net/fulltext/?doi=jm.2010.1070.1082&org=245#ref
Effective Pipetting for Bacteriocin Testing Workflows Labmate OnlineEffective Pipetting for Bacteriocin Testing Workflows Labmate Online
We also do it the other way around, pipetting bacteria onto an agar containing the bacteriocin, to see whether or not they grow ... and activity testing of the antimicrobial bacteriocins produced via transient transformation. The preparation and dispensing of ... then we know our bacteriocins are active. ... Effective Pipetting for Bacteriocin Testing Workflows. Learn ...
https://www.labmate-online.com/news/laboratory-products/3/integra-biosciences-ag/effective-pipetting-for-bacteriocin-testing-workflows/57369
Characterization of bacteriocin produced by Lactobacillus plantarum F1 and Lactobacillus brevis OG1 | African Journal of...Characterization of bacteriocin produced by Lactobacillus plantarum F1 and Lactobacillus brevis OG1 | African Journal of...
Comparison of the antimicrobial spectra and characterization of the two bacteriocins were not identical. Bacteriocin produced ... which led to total loss of bacteriocin activity. The bacteriocins were able to pass through cellulose membranes with 100,000 ... Characterization of bacteriocin produced by Lactobacillus plantarum F1 and Lactobacillus brevis OG1 * S.T. Ogunbanwo ... The bacteriocins produced by the test isolates maintained full stability after storage for 60 days at - 20°C; partial stability ...
https://www.ajol.info/index.php/ajb/article/view/14770
Microbial production of bacteriocins and its applications in food preservation: A review. Microbial production of bacteriocins and its applications in food preservation: A review.
Bacteriocins, a heterogeneous group of bioactive bacterial peptides or proteins, are ribosomally synthesized that inhibit or ... Classification of Bacteriocins. Bacteriocins are classified into different groups (Table 2). Class I bacteriocins (lantibiotics ... Table 6: Potential applications of bacteriocin in various formulations sector.. Bacteriocin Toxicity. Bacteriocins have been ... non-modified bacteriocins; class III, large (,10000) heat-labile bacteriocins; and class IV, complex bacteriocins, carrying ...
https://www.alliedacademies.org/articles/microbial-production-of-bacteriocins-and-its-applications-in-food-preservation-a-review-15940.html
Constructing Social Reality Glossary - Annenberg LearnerConstructing Social Reality Glossary - Annenberg Learner
Bacteriocin. Proteins produced by some bacteria, which inhibit the growth of other strains of the same organism or related ...
https://www.learner.org/glossary/constructing-social-reality/
Changes in cell surface and metabolism associated with strains of Listeria monocytogenes displaying different sensitivities to...Changes in cell surface and metabolism associated with strains of Listeria monocytogenes displaying different sensitivities to...
It is possible that this may result in reduced activity of the bacteriocin in resistant cell membranes as a-helical stucture is ... Mutants of the L. monocytogenes 873 isolate, resistant to the class IIa bacteriocin, leucocin A, were generated at the start of ... It is conceivable that more fluid membranes could also impact on decreased stability of pore formation by the bacteriocin. ... The high frequencies of resistance to class Ha bacteriocins have however sparked concern regarding their adequacy as potential ...
https://scholar.sun.ac.za/handle/10019.1/53326
Synergy between circular bacteriocin AS-48 and ethambutol against mycobacterium tuberculosis - GHTMSynergy between circular bacteriocin AS-48 and ethambutol against mycobacterium tuberculosis - GHTM
Synergy between circular bacteriocin AS-48 and ethambutol against mycobacterium tuberculosis. *Autores: Aguilar-Pérez C, Garcia ... In summary, bacteriocin AS-48 has an interesting antimycobacterial activity in vitro and low cytotoxicity, so further studies ... Bacteriocin AS-48 is an antibacterial peptide produced by Enterococcus faecalis, active against several Gram-positive bacteria ... Synergy between circular bacteriocin AS-48 and ethambutol against mycobacterium tuberculosis. ...
https://ghtm.ihmt.unl.pt/publications/synergy-circular-bacteriocin-48-ethambutol-mycobacterium-tuberculosis/
Bacteriocin-encoding genes and ExPEC virulence determinants are associated in human fecal Escherichia coli strains | BMC...Bacteriocin-encoding genes and ExPEC virulence determinants are associated in human fecal Escherichia coli strains | BMC...
Bacteriocin synthesis appears to modulate the ability of E. coli strains to reside in the human intestine and/or the virulence ... The occurrence of bacteriocin-encoding genes was found to be positively correlated with the occurrence of E. coli virulence ... The occurrence of bacteriocin-encoding genes and ExPEC virulence determinants correlate positively in E. coli strains of human ... Altogether, 17 virulence determinants and 31 bacteriocin-encoding genes were tested in each of them. ...
https://bmcmicrobiol.biomedcentral.com/articles/10.1186/1471-2180-14-109/figures/2
View of Antibacterial activity of bacteriocin produced by Bacillus velezensis BUU004, herb extracts and their combination for...View of Antibacterial activity of bacteriocin produced by Bacillus velezensis BUU004, herb extracts and their combination for...
Return to Article Details Antibacterial activity of bacteriocin produced by Bacillus velezensis BUU004, herb extracts and their ...
https://ejournals.swu.ac.th/index.php/ssj/article/view/13052/11063
EN (en)EN (en)
Bacteriocin from epidemic Listeria strains alters the host intestinal microbiota to favor infection.. ... To our knowledge, these results therefore identify LLS as the first bacteriocin described in L. monocytogenes and associate ... Listeriolysin S is a bacteriocin specifically produced in the intestine of orally infected mice and necessary for Listeria ... is a bacteriocin highly expressed in the intestine of orally infected mice that alters the host intestinal microbiota and ...
https://research.pasteur.fr/en/publication/bacteriocin-from-epidemic-listeria-strains-alters-the-host-intestinal-microbiota-to-favor-infection/
Download Bacteriocins: Ecology And Evolution 2007Download Bacteriocins: Ecology And Evolution 2007
... Science looked him nt. He had s sapped in past Gheberling.de. He wanted ... She tried with them as they brought download Bacteriocins: Ecology and Evolution 2007 and was full-time. I abruptly arrived I ...
http://gheberling.de/korsika/book.php?q=download-Bacteriocins%3A-Ecology-and-Evolution-2007.php
JoF | Free Full-Text | Candida spp./Bacteria Mixed BiofilmsJoF | Free Full-Text | Candida spp./Bacteria Mixed Biofilms
EntV is a bacteriocin encoded by the EntV (ef1097) locus, documented for decreasing C. albicans virulence and biofilm formation ... EntV (bacteriocin). Antibiofilm. [144]. Candida albicans and Streptococcus mutans Derivative thiazolidinedione-8 (S-8), in ...
https://www.mdpi.com/2309-608X/6/1/5
IMSEAR at SEARO: Bacteriocin production in Salmonella.
Bacteriocin production in Salmonella. Journal of Postgraduate Medicine. 1985 Jan; 31(1): 46-51. ...
https://imsear.searo.who.int/handle/123456789/116571
Class IIa bacteriocin enterocin A (Fragment)
Class IIa bacteriocin enterocin A (Fragment ...
http://camp3.bicnirrh.res.in/seqDisp.php?id=CAMPSQ5583
peptalk-2017 - Syngulon - Bacteriocin-based technologiespeptalk-2017 - Syngulon - Bacteriocin-based technologies
Microbial fermentation technologies, selection technology, antibiotic-free, genetic drift, contamination prevention, Bacteriocin-based technologies, alternative to antibiotics
https://syngulon.com/peptalk-2017/
Bivariate Data and Analysis Glossary - Annenberg LearnerBivariate Data and Analysis Glossary - Annenberg Learner
Bacteriocin. Proteins produced by some bacteria, which inhibit the growth of other strains of the same organism or related ...
https://www.learner.org/glossary/bivariate-data-and-analysis/
H. Abriouel | Semantic ScholarH. Abriouel | Semantic Scholar
Application of bacteriocins in the control of foodborne pathogenic and spoilage bacteria.. *A. Gálvez, R. López, H. Abriouel, E ... Bacteriocin-based strategies for food biopreservation.. *A. Gálvez, H. Abriouel, R. López, N. ben Omar ... Diversity of enterococcal bacteriocins and their grouping in a new classification scheme.. *C. Franz, M. V. van Belkum, W. ... Diversity and applications of Bacillus bacteriocins.. *H. Abriouel, C. Franz, N. ben Omar, A. Gálvez ...
https://www.semanticscholar.org/author/H.-Abriouel/4658481
bacteriocin Archives - International Scientific Association for Probiotics and Prebiotics (ISAPP)bacteriocin Archives - International Scientific Association for Probiotics and Prebiotics (ISAPP)
This month, ISAPP board member and former president Professor Colin Hill received a prestigious award from University College Cork (Ireland), where he has worked since 1992: The UCC Career Achievement Research Award. The prize honours leading researchers whose influential work has been recognized globally.. Hills research interests lie in molecular microbiology-specifically, issues around infection. His team was the first to discover lacticin 3147 and thuricin CD, two examples of a class of anti-microbials produced by bacteria that kill bacteria. He is also a leading scientist exploring the human virome: his team developed tools for gut virome analysis, performed phage therapy in vivo, and increased the number of known phage genomes by tens of thousands. Hill is the inventor on 23 patents, has published over 570 research articles, and to date, has secured over €25 million worth of research funding. His publications and citations put him in the top 1% of researchers worldwide.. Hill has served ...
https://isappscience.org/tag/bacteriocin/
Frontiers | Colicins and Salmocins - New Classes of Plant-Made Non-antibiotic Food AntibacterialsFrontiers | Colicins and Salmocins - New Classes of Plant-Made Non-antibiotic Food Antibacterials
Potential Markets for Bacteriocins as Food Antibacterials. Bacteriocins such as colicins and salmocins are promising ... Table 1. Bacteriocins versus antibiotics: major biological differences and market potential of bacteriocins. ... 2018). Plant-made Salmonella bacteriocins salmocins for control of Salmonella pathovars. Sci. Rep. 8:4078. doi: 10.1038/s41598- ... The generation of bacteriocin-transgenic N. benthamiana was published in Schulz et al. (2015) and Schneider et al. (2018). ...
https://www.frontiersin.org/articles/10.3389/fpls.2019.00437/full
Inhibitory effect of streptococci on the growth of M. catarrhalis strains and the diversity of putative bacteriocin-like gene...Inhibitory effect of streptococci on the growth of M. catarrhalis strains and the diversity of putative bacteriocin-like gene...
We observed that a set of bacteriocin-like genes in the genome of S. mitis is greatly poorer in comparison with S. pneumoniae ... so we examined the genomes of our strains for the presence of bacteriocin-like peptides encoding genes. ... one; moreover, in one S. mitis strain we found no bacteriocin-like genes. It could mean that there are probably some additional ... From: Inhibitory effect of streptococci on the growth of M. catarrhalis strains and the diversity of putative bacteriocin-like ...
https://amb-express.springeropen.com/articles/10.1186/s13568-017-0521-z/figures/5
Table - 15th International Workshop on Campylobacter, Helicobacter and Related Organisms - Volume 16, Number 7-July 2010 -...
Bacteriocin reduces colonization. Hanan et al. (10). Lytic bacteriophage therapy. UK. 2 log reduction in cecal levels of birds. ... Use of bacteriocins. USA. 5-6 log reduction in cecal contents, 3 d prior to slaughter. Svetoch and Stern (7). ... Potentials for bacteriocin development to control Campylobacter in broilers. In: Proceedings of the 15th International Workshop ...
https://wwwnc.cdc.gov/eid/article/16/7/10-0157-t1
Bacterial Secretome Analysis in Hunt for Novel Bacteriocins with Ability to Control Xanthomonas citri subsp. CitriBacterial Secretome Analysis in Hunt for Novel Bacteriocins with Ability to Control Xanthomonas citri subsp. Citri
Results: The two bacteriocins showed an activity up to 55ºC that were sensitive to proteases suggesting being protein in nature ... Varieties of means have been used to minimize its devastating effects, but no attention has been given to bacteriocins. ... Objectives: Here and for the first time, we report the isolation and characterization of two novel bacteriocins. Materials and ... The effects of varieties of carbon, nitrogen and phosphate sources were evaluated on both bacterial growth and bacteriocin ...
http://www.ijbiotech.com/article_10993.html
Publication : USDA ARSPublication : USDA ARS
The presence of nisin, a food grade bacteriocin approved for human consumption, was required for optimum bacteriocin production ... Some LAB are unable to grow in milk because they cannot use lactose, but dairy LAB can be made to produce bacteriocins as ... In this study, we developed a way to introduce a bacteriocin, which inhibits the growth of Listeria, into dairy LAB such as ... Bacteriocin expression was shown to effectively inhibit the growth of the food pathogen Listeria monocytogenes. These results ...
https://www.ars.usda.gov/research/publications/publication/?seqNo115=232638
Advances in Fermented Foods and Beverages - 1st EditionAdvances in Fermented Foods and Beverages - 1st Edition
Biopreservative effect of bacteriocins. *13.7. Biopreservative effect of other compounds. *13.8. Conclusions ...
https://www.elsevier.com/books/advances-in-fermented-foods-and-beverages/holzapfel/978-1-78242-015-6
Genomic analyses of pneumococci reveal a wide diversity of bacteriocins - including pneumocyclicin, a novel circular...
RESULTS: We found that all genomes maintained a blp bacteriocin cassette and we identified several novel blp cassettes and ... The composition of the bacteriocin/immunity region of the blp cassette was highly variable: one cassette possessed six ... Most surprisingly, one-third of pneumococcal genomes also possessed a cassette encoding a novel circular bacteriocin that we ... CONCLUSIONS: These detailed genomic analyses revealed a novel pneumocyclicin cassette and a wide variety of blp bacteriocin ...
https://www.expmedndm.ox.ac.uk/publications/535611?9d3d15c8-7673-11ed-857e-061b866677b4
IUCr) Acta Crystallographica Section D Volume 60, Part 10, October 2004IUCr) Acta Crystallographica Section D Volume 60, Part 10, October 2004
Overexpression, purification and crystallization of bacteriocin LlpA from Pseudomonas sp. BW11M1. A. H. A. Parret, L. Wyns, R. ... The crystallization and preliminary X-ray analysis of the lectin-like bacteriocin LlpA from Pseudomonas sp. BW11M1 is described ...
https://journals.iucr.org/d/issues/2004/10/00/
Transcriptomic and proteomic profiling response of methicillin-resistant Staphylococcus aureus (MRSA) to a novel bacteriocin,...Transcriptomic and proteomic profiling response of methicillin-resistant Staphylococcus aureus (MRSA) to a novel bacteriocin,...
Transcriptomic and proteomic profiling response of methicillin-resistant Staphylococcus aureus (MRSA) to a novel bacteriocin, ...
https://pesquisa.bvsalud.org/perinatal/resource/pt/mdl-32803295
DeCS 2016 - June 12, 2016 versionDeCS 2016 - June 12, 2016 version
Bacteriocin Factor use Bacteriocin Plasmids Bacteriocin Factors use Bacteriocin Plasmids Bacteriocin Plasmid use Bacteriocin ...
https://decs.bvs.br/I/DeCS2016_Alfab-B.htm
BacteriaCharacterizationPutativeSalmonellaBacillusNovel bacteriocinsPreservativesAntibacterialPeptidesNisinGenesAntibioticsProteinsStrainsProbioticsPediocinInhibitory effectGenomicProteinaceousBiofilm formationListeriaEncapsulationProductionGeneDiversityVirulenceMonocytogenesCircularActivityStreptococcusSynthesisInteractionsSubstancePotentialProducerStabilityEffect
Bacteria21
  • This is particularly the case for bacteriocins, a very diverse group of antimicrobial peptides produced by bacteria and usually encoded by small, poorly conserved ORFs. (nih.gov)
  • Bacteriocins are a group of antimicrobial peptides produced by bacteria as a protection strategy against other bacteria. (europa.eu)
  • By combining experimental methods and bioinformatics, researchers will explore the role of bacteriocin immunity genes in bacteria interacting during biofilm formation. (europa.eu)
  • This study was conducted to evaluate the antifungal activity of bacteriocins of lactic acid bacteria from some Nigerian fermented foods (Eko, Fufu, Iru and Ogi). (scialert.net)
  • Screening of 25 bacteriocin-producing Lactic Acid Bacteria (LAB) isolated from Eko, Fufu, Iru and Ogi against three spoilage fungi ( Penicillium citrinum , Aspergillus niger and A. flavus) associated with stored fermented foods revealed that 68% of the isolates possessed antifungal activity. (scialert.net)
  • We do a 'spot-on-lawn' assay where we pipette drops of our peptide solutions onto bacteria grown on agar gel in square petri dishes (12 x 12 cm) and, if the bacteria are killed, then we know our bacteriocins are active. (labmate-online.com)
  • We also do it the other way around, pipetting bacteria onto an agar containing the bacteriocin, to see whether or not they grow. (labmate-online.com)
  • Lactobacillus plantarum F1 and L. brevis OG1 isolated from Nigerian fermented food products, produced bacteriocins that had broad spectrum of inhibition against both pathogenic, food spoilage organisms and various lactic acid bacteria. (ajol.info)
  • The paper concluded that the ability of bacteriocins produced by the test isolates in inhibiting a wide-range of bacteria, is of potential interest for food safety and may have future applications as food preservative. (ajol.info)
  • Bacteriocins are a large family of ribosomally synthesized proteinaceous toxins produced by bacteria and Archaea that have antimicrobial activity against bacteria closely related to the producer strain [ 9 ]. (alliedacademies.org)
  • The cell envelope (cell wall and cell membrane) is therefore envisaged as a key site of modification in suscepti bility of bacteria to class Ha bacteriocins. (sun.ac.za)
  • Bacteriocin AS-48 is an antibacterial peptide produced by Enterococcus faecalis , active against several Gram-positive bacteria. (unl.pt)
  • Application of bacteriocins in the control of foodborne pathogenic and spoilage bacteria. (semanticscholar.org)
  • Materials and Methods: Secretome containing bacteriocins of isolated bacteria was separated via SDS-PAGE. (ijbiotech.com)
  • Ribosomally synthesized antimicrobial peptides also known as bacteriocins with detrimental effect on limited bacterial host range can play an important role in the biocontrol of plant pathogenic bacteria species (2, 3). (ijbiotech.com)
  • Fortunately, some lactic acid bacteria (LAB) considered safe for human consumption have been shown to produce peptides, short proteins called bacteriocins, which inhibit the growth of other bacteria including foodborne pathogens. (usda.gov)
  • Pneumococci reside in the paediatric nasopharynx, where they compete for space and resources, and one competition strategy is to produce a bacteriocin (antimicrobial peptide or protein) to attack other bacteria and an immunity protein to protect against self-destruction. (ox.ac.uk)
  • Survival of bacteriocins and probiotic bacteria in vivo is studied using mice and rats as models. (sun.ac.za)
  • Characterization of novel bacteriocins produced by lactic acid bacteria. (sun.ac.za)
  • The study of antimicrobial bacteriocins produced by agrobacteria within host plants is a crucial research area for NOMAD, and the company works with various bacteria, including Klebsiella, Pseudomonas, Clostridia, Escherichia coli and Salmonella. (integra-biosciences.com)
  • Bacteriocins are antimicrobial peptides produced by bacteria to inhibit competitors in their natural environments. (dtu.dk)
Characterization5
  • Comparison of the antimicrobial spectra and characterization of the two bacteriocins were not identical. (ajol.info)
  • This article gives an overview of the classification of bacteriocins, isolation and characterization, and mode of action. (alliedacademies.org)
  • The present review provides a general overview of Bacillus bacteriocins, including primary structure, biochemical and genetic characterization, classification and potential applications in food preservation as natural preservatives and in human and animal health as alternatives to conventional antibiotics. (semanticscholar.org)
  • Objectives: Here and for the first time, we report the isolation and characterization of two novel bacteriocins. (ijbiotech.com)
  • Characterization of bacteriocins produced by Carnobacterium maltaromaticum C2, isolated. (usp.br)
Putative4
  • This information can be used to locate putative structural bacteriocin genes. (nih.gov)
  • Here, we describe BAGEL, a web server that identifies putative bacteriocin ORFs in a DNA sequence using novel, knowledge-based bacteriocin databases and motif databases. (nih.gov)
  • These innovations make BAGEL unique in its ability to detect putative bacteriocin gene clusters in (new) bacterial genomes. (nih.gov)
  • The composition of the 'bacteriocin/immunity region' of the blp cassette was highly variable: one cassette possessed six bacteriocin genes and eight putative immunity genes, whereas another cassette had only one of each. (ox.ac.uk)
Salmonella2
  • IMSEAR at SEARO: Bacteriocin production in Salmonella. (who.int)
  • Bacteriocin production in Salmonella. (who.int)
Bacillus1
Novel bacteriocins1
  • Bacterial Secretome Analysis in Hunt for Novel Bacteriocins with Ability to Control Xanthomonas citri subsp. (ijbiotech.com)
Preservatives4
  • Since they pose no health risk concerns, soon bacteriocins are largely dependent on their use as safe food preservatives. (alliedacademies.org)
  • ENGLISH ABSTRACT: The possible use of the bacterially produced antimicrobial peptides, and in particular class IIa bacteriocins as food preservatives is a motivating factor in studies on resistance to them by food-borne pathogens like Listeria monocytogenes. (sun.ac.za)
  • Application of bacteriocins may help reduce the use of chemical preservatives and/or the intensity of heat and other physical treatments, satisfying the demands of consumers for foods that are fresh tasting, ready to eat, and lightly preserved. (semanticscholar.org)
  • Some LAB are unable to grow in milk because they cannot use lactose, but dairy LAB can be made to produce bacteriocins as natural preservatives in fermented dairy products. (usda.gov)
Antibacterial1
  • Exceptionally few bacteriocins along with their native antibacterial property also exhibit additional anti-viral and antifungal properties [ 10 ]. (alliedacademies.org)
Peptides4
  • Bacteriocins, a heterogeneous group of bioactive bacterial peptides or proteins, are ribosomally synthesized that inhibit or kill other related or unrelated microorganisms. (alliedacademies.org)
  • It is possible that this may result in reduced activity of the bacteriocin in resistant cell membranes as a-helical stucture is a critical feature for membrane insertion of cationic antimicrobial peptides. (sun.ac.za)
  • Isolates are screened for the production of novel antimicrobial peptides (bacteriocins) and also selected for probiotic properties. (sun.ac.za)
  • This allows expression of the target bacteriocin peptides in the plant, which is followed by peptide purification downstream studies to investigate the antimicrobial activities of the bacteriocins that are obtained. (integra-biosciences.com)
Nisin2
  • The presence of nisin, a food grade bacteriocin approved for human consumption, was required for optimum bacteriocin production. (usda.gov)
  • Under carbohydrate starvation stress, we investigated the generation of non-culturable forms of three bacteriocin (nisin) producing Lactococcus lactis subsp. (2pressrelease.net)
Genes6
  • ORFs surrounding bacteriocin genes are often biosynthetic genes. (nih.gov)
  • Many bacteriocins are encoded by small genes that are often omitted in the annotation process of bacterial genomes. (nih.gov)
  • In addition, BAGEL takes into account the genomic context, i.e. for each potential bacteriocin-encoding ORF, the sequence of the surrounding region on the genome is analyzed for genes that might encode proteins involved in biosynthesis, transport, regulation and/or immunity. (nih.gov)
  • They are found in gene clusters that encompass genes involved in bacteriocin production, immunity and transport. (europa.eu)
  • RESULTS: We found that all genomes maintained a blp bacteriocin cassette and we identified several novel blp cassettes and genes. (ox.ac.uk)
  • Genes encoding bacteriocin production, and adhesion to epithelial cells and mucus layers are sequenced and expressed in different bacterial hosts. (sun.ac.za)
Antibiotics3
  • Moreover, considering that bacteriocins have been suggested as potential alternatives to antibiotics in the future, project results will have important consequences for the healthcare sector. (europa.eu)
  • Use of microbial exudates including but not limited to antibiotics, proteinaceous exotoxins, lysozymes, and bacteriocins (1) may reduce the population of bacterial pathogens during seasonal outbreak. (ijbiotech.com)
  • Microorganisms residing within biofilms are highly resistant to antimicrobials including antibiotics and bacteriocins produced by probiotics. (revelationhealth.com)
Proteins1
  • The scope of the EU-funded BOB project is to map bacteriocin gene clusters with associated immunity proteins in oral streptococci. (europa.eu)
Strains5
  • In addition, treatment with a desaturase inhibitor resulted in increased sensitivity of only the intermediate resistant strains to the class na bacteriocin, leucocin A. This indicated the influence of membrane adaptation in only lower levels of resistance. (sun.ac.za)
  • Bacteriocin from epidemic Listeria strains alters the host intestinal microbiota to favor infection. (pasteur.fr)
  • Here, we demonstrate that Listeriolysin S (LLS), a virulence factor only present in a subset of lineage I strains, is a bacteriocin highly expressed in the intestine of orally infected mice that alters the host intestinal microbiota and promotes intestinal colonization by L. monocytogenes, as well as deeper organ infection. (pasteur.fr)
  • To our knowledge, these results therefore identify LLS as the first bacteriocin described in L. monocytogenes and associate modulation of host microbiota by L. monocytogenes epidemic strains to increased virulence. (pasteur.fr)
  • Similarity of bacteriocin activity profi les of mutans streptococci within the family when the children acquire the strains after the age of 5. (bvsalud.org)
Probiotics2
  • The interventions reported at the meeting were largely for adoption in industrialized nations and followed the themes of biosecurity, use of bacteriophages, bacteriocins, probiotics, antimicrobial drugs, and vaccination and reported varying degrees of success. (cdc.gov)
  • Both the LactORN and the No.7 Systemic Booster contain ingredients that challenge our immune system-namely, the oligoribonucleotides (ORNs) and the supernatant broth (whole dead-cells of probiotics, vitamins & minerals, enzymes, bacteriocin, ORNs, and more), respectively. (bioimmersion.com)
Pediocin5
  • Here, we identify Corynebacterium glutamicum as a suitable production host for the bacteriocin pediocin PA-1. (dtu.dk)
  • C. glutamicum CR099 shows resistance to high concentrations of pediocin PA-1 and the bacteriocin was not inactivated when spiked into growing cultures of this bacterium. (dtu.dk)
  • Overall, we demonstrate that C. glutamicum is a suitable host for recombinant production of bacteriocins of the pediocin family. (dtu.dk)
  • The bacteriocin pediocin PA-1 has potential use as a food biopreservative, and understanding its effect on the commensal gut microbiota is important for assessment of consumer risks associated with the use of biopreservative cultures. (dtu.dk)
  • Pediocin PA-1 did not mediate changes of the rat microbiota, and a biological assay indicated that the bacteriocin was degraded or inactivated during passage through the intestine. (dtu.dk)
Inhibitory effect2
  • The inhibitory effect of the bacteriocins on spore germination of P. citrinum ranged from 2.44 to 85.36% in Lactobacillus casei FF1 and L. brevis SG1, respectively. (scialert.net)
  • Recombinant CBM 588 bacteriocin (CBM-B) was constructed and demonstrated to have inhibitory effect against C. difficile . (okstate.edu)
Genomic2
  • Genomic analyses of pneumococci reveal a wide diversity of bacteriocins - including pneumocyclicin, a novel circular bacteriocin. (ox.ac.uk)
  • CONCLUSIONS: These detailed genomic analyses revealed a novel pneumocyclicin cassette and a wide variety of blp bacteriocin cassettes, suggesting that competition in the nasopharynx is a complex biological phenomenon. (ox.ac.uk)
Proteinaceous1
  • Their active principle was proteinaceous in nature since the bacteriocins were inactivated by proteolytic enzymes, but not by other non-proteolytic enzymes. (ajol.info)
Biofilm formation1
  • Transcriptomic and proteomic profiling response of methicillin-resistant Staphylococcus aureus (MRSA) to a novel bacteriocin, plantaricin GZ1-27 and its inhibition of biofilm formation. (bvsalud.org)
Listeria3
  • Listeriolysin S is a bacteriocin specifically produced in the intestine of orally infected mice and necessary for Listeria monocytogenes survival in this organ. (pasteur.fr)
  • In this study, we developed a way to introduce a bacteriocin, which inhibits the growth of Listeria, into dairy LAB such as Streptococcus thermophilus, Lactococcus lactis and Lactobacillus casei. (usda.gov)
  • Bacteriocin expression was shown to effectively inhibit the growth of the food pathogen Listeria monocytogenes. (usda.gov)
Encapsulation2
  • Bacteriocins and probiotic cells are protected from the hostile environment in the gut by encapsulation into nanofibers and nanoparticles. (sun.ac.za)
  • Encapsulation of bacteriocins and probiotic cells in nanofibers and nanoparticles prepared from different polymers. (sun.ac.za)
Production5
  • Microbial production of bacteriocins and its applications in food preservation: A review. (alliedacademies.org)
  • Garai B, Purkait A, Ghose T ,et al.Microbial production of bacteriocins and its applications in food preservation: A review. (alliedacademies.org)
  • The effects of varieties of carbon, nitrogen and phosphate sources were evaluated on both bacterial growth and bacteriocin production via Taguchi orthogonal method. (ijbiotech.com)
  • A Taguchi orthogonal array was also implemented to determine the effect of temperature and eight other chemical factors on bacteriocin production for each bacterium. (ijbiotech.com)
  • Following isolation of bacteriocins, the bacterial culture media were optimized towards faster bacterial growth and higher bacteriocin production. (ijbiotech.com)
Gene1
  • The plasmid insertion conferring the antilisterial-peptide- negative phenotype was located in a seven-gene operon (alb, for antilisterial bacteriocin) residing immediately downstream from the sbo gene, which encodes the precursor of subtilosin. (elsevier.com)
Diversity2
  • Diversity of enterococcal bacteriocins and their grouping in a new classification scheme. (semanticscholar.org)
  • We analysed a collection of 336 diverse pneumococcal genomes dating from 1916 onwards, identified bacteriocin cassettes, detailed their genetic composition and sequence diversity, and evaluated the data in the context of the pneumococcal population structure. (ox.ac.uk)
Virulence1
  • Correspondence analysis for bacteriocin types and virulence factors. (biomedcentral.com)
Monocytogenes1
  • Mutants of the L. monocytogenes 873 isolate, resistant to the class IIa bacteriocin, leucocin A, were generated at the start of the study to complement the existing array of L. monocytagenes wild-type and resistant isolates obtained from other sources. (sun.ac.za)
Circular2
  • including pneumocyclicin, a novel circular bacteriocin. (ox.ac.uk)
  • Most surprisingly, one-third of pneumococcal genomes also possessed a cassette encoding a novel circular bacteriocin that we called pneumocyclicin, which shared a similar genetic organisation to well-characterised circular bacteriocin cassettes in other bacterial species. (ox.ac.uk)
Activity6
  • Research scientist Birgit Koch explained how she uses the VOYAGER in her work: "My research is focused on molecular cloning, to generate plant virus-based expression vectors that are transferred using agrobacteria into the host plants, and activity testing of the antimicrobial bacteriocins produced via transient transformation. (labmate-online.com)
  • while activity was not detected after storage for 80 to 120 days at 37°C. Bacteriocin produced by L. brevis OG1 was stable at pH range of 2.0 to 8.0 while, that of L. plantarum F1 was found to be stable at pH 2.0 to 6.0. (ajol.info)
  • mitomycin C and uv light did not affect the activity of the bacteriocins, while chloroform extraction completely destroyed their activity. (ajol.info)
  • Exposure to surfactant resulted in an increase in the bacteriocin titre, except Nonidet P-40, which led to total loss of bacteriocin activity. (ajol.info)
  • In summary, bacteriocin AS-48 has an interesting antimycobacterial activity in vitro and low cytotoxicity, so further studies in vivo will contribute to its development as a potential additional drug for antituberculosis therapy. (unl.pt)
  • Results: The two bacteriocins showed an activity up to 55ºC that were sensitive to proteases suggesting being protein in nature. (ijbiotech.com)
Streptococcus1
  • detection of bacteriocin-like inhibitory substance against streptococcus mutans. (ukm.my)
Synthesis1
  • Comparison of the presubtilosin and mature subtilosin sequences suggested that certain residues undergo unusual posttranslational modifications unlike those occurring during the synthesis of class I (lantibiotic) or some class II bacteriocins. (elsevier.com)
Interactions1
  • This neutralisation of the negative charge of the cell surface may interfere with initial electrostatic interaction of bacteriocin with the cell, and subsequent interactions required for permeabilisation of the cell membrane. (sun.ac.za)
Substance1
  • Amino acid analysis confirmed that the substance was the cyclic bacteriocin subtilosin. (elsevier.com)
Potential2
  • Besides, this article stated the potential applications of bacteriocin in the bactericidal formulations sector. (alliedacademies.org)
  • The high frequencies of resistance to class Ha bacteriocins have however sparked concern regarding their adequacy as potential biopreservatives. (sun.ac.za)
Producer1
  • Currently, commercial bacteriocins are produced exclusively with natural producer organisms on complex substrates and are sold as semi-purified preparations or crude fermentates. (dtu.dk)
Stability1
  • It is conceivable that more fluid membranes could also impact on decreased stability of pore formation by the bacteriocin. (sun.ac.za)
Effect1
  • Another project focuses on the effect bacteriocins may have on cancer cells. (sun.ac.za)
JoF | Free Full-Text | Candida spp./Bacteria Mixed Biofilms
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The role of bacteriocins in shaping oral biofilms | BOB Project | Fact Sheet | H2020 | CORDIS | European Commission
The role of bacteriocins in shaping oral biofilms | BOB Project | Fact Sheet | H2020 | CORDIS | European Commission (cordis.europa.eu)
H. Abriouel | Semantic Scholar
H. Abriouel | Semantic Scholar (semanticscholar.org)
Frontiers | Colicins and Salmocins - New Classes of Plant-Made Non-antibiotic Food Antibacterials
Frontiers | Colicins and Salmocins - New Classes of Plant-Made Non-antibiotic Food Antibacterials (frontiersin.org)
Recently Published GRAS Notices and FDA Letters | FDA
Recently Published GRAS Notices and FDA Letters | FDA (fda.gov)
IUCr) Acta Crystallographica Section D Volume 60, Part 10, October 2004
IUCr) Acta Crystallographica Section D Volume 60, Part 10, October 2004 (journals.iucr.org)
Lactobacillus curvatus UFV-NPAC1 and other lactic acid bacteria isolated from calabresa, a fermented meat product, present high...
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Frontiers | Turn Up the Heat-Food and Clinical Escherichia coli Isolates Feature Two Transferrable Loci of Heat Resistance
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Bacillus Coagulans: MedlinePlus Supplements
Bacillus Coagulans: MedlinePlus Supplements (medlineplus.gov)
Mgr. Juraj Bosák, Ph.D. - Publications | Masaryk University
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YSP Research Projects - UC Davis School of Education
YSP Research Projects - UC Davis School of Education (education.ucdavis.edu)
Staff Members
Staff Members (in.bgu.ac.il)
Antifungal Activity of Bacteriocins of Lactic Acid Bacteria from Some Nigerian Fermented Foods
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Spring 2017- GMN Global Food Safety Forum: Perspectives on Packaging
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Bioline International Official Site (site up-dated regularly)
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Sunstar Innovation Grant
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Establishing recombinant production of pediocin PA-1 in <i>Corynebacterium glutamicum<...
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Microbial production of bacteriocins and its applications in food preservation: A review.
Microbial production of bacteriocins and its applications in food preservation: A review. (alliedacademies.org)
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Vol 35 (2018)
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Diversity | Free Full-Text | Genome Sequence of Dickeya solani, a New soft Rot Pathogen of Potato, Suggests its Emergence May...
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