Bacteriocins
Pediococcus
Lactobacillus
Pyocins
Nisin
Listeria
Lactobacillaceae
Gram-Positive Asporogenous Rods
Antibiosis
Lactococcus
Colicins
Lactobacillus acidophilus
Amino Acid Sequence
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Lactococcus lactis
Leuconostoc
Enterococcus faecium
Listeria monocytogenes
Streptococcus mutans
Enterococcus faecalis
Hafnia alvei
Microbial Sensitivity Tests
Streptococcus
Bacteria
One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.
Yogurt
Clostridium perfringens
Enterococcus
Sequence Homology, Amino Acid
Mitomycins
Sequence Alignment
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
Spheroplasts
Base Sequence
Bacillus
Effect of a staphylococcin on Neisseria gonorrhoeae. (1/1664)
Phage group 2 staphylococcal strain UT0002 contains a large 56S virulence plasmid with genes that code for both exfoliative toxin and a specific staphylococcin termed Bac R(1). Four penicillinase-producing strains and three penicillin-susceptible strains of Neisseria gonorrhoeae were killed by Bac R(1). After 30 min of growth of the penicillin-resistant TR1 strain in 62.5 arbitrary units of Bac R(1) per ml, loss of viability was approximately 90%, and, after 5 h, an approximately 99.99% loss of viability was observed. Lysis did not accompany cell death, and 84% of the Bac R(1) added to the growth medium was adsorbed to the gonococcal cells. The extracellular supernatant fluid from a substrain of staphylococcal strain UT0002 cured of the plasmid for Bac R(1) production had no lethal effect on the gonococcal strains. Bac R(1) was also shown to have bactericidal activity against an L-form of N. meningitidis, indicating that the outer envelope of a neisserial cell is not needed for bacteriocin activity. Ten different normal human sera were unable to neutralize Bac R(1) activity. The bacteriocin lacks adsorption specificity. It binds to but does not kill Escherichia coli cells, indicating that the cell envelope of gram-negative organisms can provide protection against the staphylococcin. (+info)Temperature and pH conditions that prevail during fermentation of sausages are optimal for production of the antilisterial bacteriocin sakacin K. (2/1664)
Sakacin K is an antilisterial bacteriocin produced by Lactobacillus sake CTC 494, a strain isolated from Spanish dry fermented sausages. The biokinetics of cell growth and bacteriocin production of L. sake CTC 494 in vitro during laboratory fermentations were investigated by making use of MRS broth. The data obtained from the fermentations was used to set up a predictive model to describe the influence of the physical factors temperature and pH on microbial behavior. The model was validated successfully for all components. However, the specific bacteriocin production rate seemed to have an upper limit. Both cell growth and bacteriocin activity were very much influenced by changes in temperature and pH. The production of biomass was closely related to bacteriocin activity, indicating primary metabolite kinetics, but was not the only factor of importance. Acidity dramatically influenced both the production and the inactivation of sakacin K; the optimal pH for cell growth did not correspond to the pH for maximal sakacin K activity. Furthermore, cells grew well at 35 degrees C but no bacteriocin production could be detected at this temperature. L. sake CTC 494 shows special promise for implementation as a novel bacteriocin-producing sausage starter culture with antilisterial properties, considering the fact that the temperature and acidity conditions that prevail during the fermentation process of dry fermented sausages are optimal for the production of sakacin K. (+info)The specific genes for lantibiotic mutacin II biosynthesis in Streptococcus mutans T8 are clustered and can be transferred en bloc. (3/1664)
Mutacin II is a ribosomally synthesized peptide lantibiotic produced by group II Streptococcus mutans. DNA sequencing has revealed that the mutacin II biosynthetic gene cluster consists of seven specific open reading frames: a regulator (mutR), the prepromutacin structural gene (mutA), a modifying protein (mutM), an ABC transporter (mutT), and an immunity cluster (mutFEG). Transformations of a non-mutacin-producing strain, S. mutans UA159, and a mutacin I-producing strain, S. mutans UA140, with chromosomal DNA from S. mutans T8 with an aphIII marker inserted upstream of the mutacin II structural gene yielded transformants producing mutacin II and mutacins I and II, respectively. (+info)Identification and cloning of an Erwinia carotovora subsp. carotovora bacteriocin regulator gene by insertional mutagenesis. (4/1664)
Avirulent Erwinia carotovora subsp. carotovora CGE234-M403 produces two types of bacteriocin. For the purpose of cloning the bacteriocin genes of strain CGE234M403, a spontaneous rifampin-resistant mutant of this strain, M-rif-11-2, was isolated. By Tn5 insertional mutagenesis using M-rif-11-2, a mutant, TM01A01, which produces the high-molecular-weight bacteriocin but not the low-molecular-weight bacteriocin was obtained. By thermal asymmetric interlaced PCR, the DNA sequence from the Tn5 insertion site and the DNA sequence of a contiguous 1,280-bp region were determined. One complete open reading frame (ORF), designated ORF2, was identified within the sequenced fragment. The 3' end of another ORF, ORF1, was located upstream of ORF2. A noncoding region and a putative promoter were located between ORF1 and ORF2. Downstream from ORF2, the 5' end of another ORF (ORF3) was found. Deduction from the nucleotide sequence indicated that ORF2 encodes a protein of 99 amino acids, which showed high homology with Yersinia enterocolitica Yrp, a regulator of enterotoxin (Y-ST) production; Escherichia coli host factor 1, required for Qbeta-replicase; and Azorhizobium caulinodans NrfA, required for the expression of nifA. ORF2 was designated brg, bacteriocin regulator gene. A fragment containing ORF2 and its promoter was amplified and cloned into pBR322 and pHSG415r, and the recombinant plasmids, pBYL1 and pHYL1, were transferred into E. coli DH5. Plasmid pBYL1 was reisolated and transferred into the insertion mutant TM01A01. Transformants carrying the plasmid, which was reisolated and designated pBYL1, re-produced the low-molecular-weight bacteriocin. (+info)Escherichia coli outer membrane protein TolC is involved in production of the peptide antibiotic microcin J25. (5/1664)
A Tn5 insertion in tolC eliminated microcin J25 production. The mutation had little effect on the expression of the microcin structural gene and presumably acted by blocking microcin secretion. The tolC mutants carrying multiple copies of the microcin genes were less immune to the microcin. TolC is thus likely a component of a microcin export complex containing the McjD immunity protein, an ABC exporter. (+info)Inactivation of the dlt operon in Staphylococcus aureus confers sensitivity to defensins, protegrins, and other antimicrobial peptides. (6/1664)
Positively charged antimicrobial peptides with membrane-damaging activity are produced by animals and humans as components of their innate immunity against bacterial infections and also by many bacteria to inhibit competing microorganisms. Staphylococcus aureus and Staphylococcus xylosus, which tolerate high concentrations of several antimicrobial peptides, were mutagenized to identify genes responsible for this insensitivity. Several mutants with increased sensitivity were obtained, which exhibited an altered structure of teichoic acids, major components of the Gram-positive cell wall. The mutant teichoic acids lacked D-alanine, as a result of which the cells carried an increased negative surface charge. The mutant cells bound fewer anionic, but more positively charged proteins. They were sensitive to human defensin HNP1-3, animal-derived protegrins, tachyplesins, and magainin II, and to the bacteria-derived peptides gallidermin and nisin. The mutated genes shared sequence similarity with the dlt genes involved in the transfer of D-alanine into teichoic acids from other Gram-positive bacteria. Wild-type strains bearing additional copies of the dlt operon produced teichoic acids with higher amounts of D-alanine esters, bound cationic proteins less effectively and were less sensitive to antimicrobial peptides. We propose a role of the D-alanine-esterified teichoic acids which occur in many pathogenic bacteria in the protection against human and animal defense systems. (+info)Membrane topology of the lactococcal bacteriocin ATP-binding cassette transporter protein LcnC. Involvement of LcnC in lactococcin a maturation. (7/1664)
Many non-lantibiotic bacteriocins of lactic acid bacteria are produced as precursors with N-terminal leader peptides different from those present in preproteins exported by the general sec-dependent (type II) secretion pathway. These bacteriocins utilize a dedicated (type I) secretion system for externalization. The secretion apparatus for the lactococcins A, B, and M/N (LcnA, B, and M/N) from Lactococcus lactis is composed of the two membrane proteins LcnC and LcnD. LcnC belongs to the ATP-binding cassette transporters, whereas LcnD is a protein with similarities to other accessory proteins of type I secretion systems. This paper shows that the N-terminal part of LcnC is involved in the processing of the precursor of LcnA. By making translational fusions of LcnC to the reporter proteins beta-galactosidase (LacZ) and alkaline phosphatase (PhoA*), it was shown that both the N- and C-terminal parts of LcnC are located in the cytoplasm. As the N terminus of LcnC is required for LcnA maturation and is localized in the cytoplasm, we conclude that the processing of the bacteriocin LcnA to its mature form takes place at the cytosolic side of the cytoplasmic membrane. (+info)Effects of antibiotics on metabolism of peptidoglycan, protein, and lipids in Bifidobacterium bifidum subsp. pennsylvanicus. (8/1664)
The formation of cell envelope components of Bifidobacterium bifidum subsp. pennsylvanicus was studied by measuring the incorporation of [(3)H]glycine, (14)C-labeled fatty acids, and N-benzoyl-[(14)C]glucosamine into the membrane protein, membrane lipids, and cell wall peptidoglycan, respectively. Inhibition of peptidoglycan synthesis by antibiotics (penicillin G, vancomycin, d-cycloserine, and bacitracin) and by the omission of glucosamine-containing growth factors caused a marked decrease in glycine incorporation into cellular as well as membrane protein, which was accompanied by a considerable enhancement of fatty acid incorporation. The uncoupling of protein and lipid synthesis led to the release of marked amounts of lipids from the cell under these conditions. Arrestment of protein synthesis by antibiotics (chloramphenicol, tetracycline, and actinomycin D) decreased peptidoglycan and lipid synthesis only partially, but did not lead to lipid release. Mg(2+) deficiency of the medium caused about 60% inhibition of growth and lipid synthesis, but protein synthesis and especially peptidoglycan synthesis were much less inhibited. Staphylococcin 1580 arrested the growth and also the synthesis of protein and peptidoglycan. However, the synthesis and turnover of lipids were considerably increased and a release of large amounts of lipids was observed. Peptidoglycan and cellular protein did not show any turnover either during normal growth or after the inhibition of cell wall and protein synthesis. (+info)
Class II bacteriocin - Wikipedia
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Molecular analysis of the replication region of the pCIZ2 plasmid from the multiple bacteriocin producer strain Enterococcus...
Determining the Virulence Properties of Escherichia coli ST131 Containing Bacteriocin-Encoding Plasmids Using Short- and Long...
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The lantibiotic peptide labyrinthopeptin A1 demonstrates broad anti-HIV and anti-HSV activity with potential for microbicidal...
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Hiracin-JM79 immunity factor elisa and antibody
Genetical identification of intibacterial agents producing microorganisms and analysis of bacteriocins and killer toxins...
Supplementary MaterialsFigure S1: Sequence alignment of BovA-like peptides. and cerecin perecin. | healthweblognews.info
Lachnobacterium bovis Whitford et al. ATCC ® BAA-151™
Cross-immunity and immune mimicry as mechanisms of resistance to the lantibiotic lacticin 3147. - PubMed - NCBI
Peptide Bacteriocins
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Activation of the expression of the microcin C51 operon upon glucose starvation of cells at the exponential growth phase,...
Properties of the Functioning of the Promoter of the Microcin C51 Operon under Different Conditions of Escherichia coliCell...
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Background Lantibiotics are lanthionine-containing, post-translationally modified antimicrobial peptides. thermodenitrificans...
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Determinants encoding fimbriae type 1 in fecal Escherichia coli are associated with increased frequency of bacteriocinogeny |...
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Bacteriocin
Colicins are bacteriocins found in the Gram-negative E. coli. Similar bacteriocins (CLBs, colicin-like bacteriocins) occur in ... Wikimedia Commons has media related to Bacteriocin. Bagel Bacteriocin Database BACTIBASE Database Bacteriocins at the US ... They are the longest studied bacteriocins. They are a diverse group of bacteriocins and do not include all the bacteriocins ... The class I bacteriocins are small peptide inhibitors and include nisin and other lantibiotics. The class II bacteriocins are ...
Bacteriocin IId
... though it lacks sequence homology with bacteriocins AS-48. Bacteriocin uses components of the mannose phosphotransferase system ... Bacteriocin AS-48 is encoded by the pheromone-responsive plasmid pMB2, and acts on the plasma membrane in which it opens pores ... Bacteriocin AS-48 is a cyclic peptide antibiotic produced by the eubacteria Enterococcus faecalis (Streptococcus faecalis) that ... González C, Langdon GM, Bruix M, Gálvez A, Valdivia E, Maqueda M, Rico M (October 2000). "Bacteriocin AS-48, a microbial cyclic ...
Class II bacteriocin
Bacteriocins for which disulfide bonds are the only modification to the peptide are Class II bacteriocins. One important and ... The class IIb bacteriocins (two-peptide bacteriocins) require two different peptides for activity. It includes the alpha ... Bacteriocin AS-48 is encoded by the pheromone-responsive plasmid pMB2, and acts on the plasma membrane in which it opens pores ... Class II bacteriocins are a class of small peptides that inhibit the growth of various bacteria. Many Gram-positive bacteria ...
Halocin
... s are bacteriocins produced by halophilic Archaea and a type of archaeocin. Since their discovery in 1982, halocins have ... Like other bacteriocins, the halocins are under investigation as antimicrobials for use in controlling spoilage during ... BACTIBASE database is an open-access database for bacteriocins including halocins (view complete list). Li Y, Xiang H, Tan H ( ... Halocins are particularly interesting because of the way the pore-forming bacteriocins have been used to probe cell membrane ...
Sakacin
... s are bacteriocins produced by Lactobacillus sakei. They are often clustered with the other lactic acid bacteriocins. ... Sakacin T is a class II bacteriocin. It is produced from a single operon with sakacin X; there are three distinct promoters in ... Sakacin T Sakacin X is a class IIa bacteriocin. It appears in the references with Sakacin T (above). Sakacin Z was apparently ... Diep DB, Axelsson L, Grefsli C, Nes IF (2000). "The synthesis of the bacteriocin sakacin A is a temperature-sensitive process ...
Bisin
Lantibiotics, Food preservation, Peptides, Bacteriocins). ...
Bokashi (horticulture)
De Vuyst, L.; Vandamme, E.J. (1994). "Antimicrobial Potential of Lactic Acid Bacteria". Bacteriocins of Lactic Acid Bacteria. ...
Nisin
... , as a class I bacteriocin, is very stable at acidic pHs and is more heat stable at lower pHs. The mode of action of Nisin ... While in general most bacteriocins inhibit only closely related species, nisin is a rare example of a "broad-spectrum" ... "Bacteriocins and their Food Applications". Comprehensive Reviews in Food Science and Food Safety. 2 (3): 82-100. doi:10.1111/j. ... bacteriocin effective against many Gram-positive organisms, including lactic acid bacteria (commonly associated to avoid food ...
Food packaging
... bacteriocins (e.g. nisin, natamycin); and essential oils. In the last decades, the use of modified atmosphere packaging (MAP) ...
Vibriocin
Like other bacteriocins, vibriocins are protein toxins. They can kill bacteria beyond the genus Vibrio, including other ... Vibriocins are a group of bacteriocins produced by, and active against, gram-negative bacteria in the genus Vibrio. They were ... Israil AM, Nacescu N, Ciufecu C, Stefanescu C (1983). "Studies on bacteriocin production by NAG-strains of Vibrio cholerae as a ... Chakrabarty AN, Adhya S, Basu J, Dastidar SJ (1970). "Bacteriocin Typing of Vibrio cholerae". Infection and Immunity. 1 (3): ...
Microbial symbiosis and immunity
However, bacteriocins can also induce death by translocating into the periplasmic space and cleaving DNA non-specifically ( ... Additionally, bacteriocins are particularly promising due to their difference in mechanisms than antibiotics meaning many ... For example, in vitro growth of methicillin-resistant S. aureus (MRSA) was inhibited by the bacteriocin nisin A, produced by ... Various commensals (primarily Gram-positive bacteria), secrete bacteriocins, peptides which bind to receptors on closely ...
Behavioral ecology
Another example is bacteria that release bacteriocins. The bacteria that releases the bacteriocin may have to die to do so, but ... This is because the ability to produce and release the bacteriocin is linked to an immunity to it. Therefore, close relatives ... most of the harm is to unrelated individuals who are killed by the bacteriocin. ...
Food spoilage
"Control of food spoilage molds using lactobacillus bacteriocins". Journal of Pure and Applied Microbiology. 12 (3): 1365-1373. ...
Sylvie Garneau-Tsodikova
Sylvie Garneau; Nathaniel I Martin; John C Vederas (1 May 2002). "Two-peptide bacteriocins produced by lactic acid bacteria". ...
Pediococcus acidilactici
Genetics of bacteriocins produced by lactic acid bacteria. FEMS Microbiol. Rev. 12 :39S-85S Barros R.R., Carvalho G.S., Peralta ... Anti-Listeria effect of enoterocin A, produced by cheese-isolated Enterococcus faecium EFM01, relative to other bacteriocins ... Association of a 13.6-megadalton plasmid in Pediococcus pentosaceus with bacteriocin activity. Appl. Environ. Microbiol. 50: ... primarily through the production of lactic acid and secretion of bacteriocins known as pediocins. P. acidilactici has a wide ...
Antibiotic use in livestock
Another research team was able to use bacteriocins, antimicrobial peptides and bacteriophages in the control of bacterial ... Joerger R.D. (2003). "Alternatives to antibiotics: bacteriocins, antimicrobial peptides and bacteriophages". Poultry Science. ...
Lactic acid bacteria
Nisin, a bacteriocin produced by LAB, was first researched as a food preservative in 1951 and has since been widely ... Some LAB produce bacteriocins which limit pathogens by interfering with cell wall synthesis or causing pore formation in the ... Proteinaceous bacteriocins are produced by several LAB strains and provide an additional hurdle for spoilage and pathogenic ... Delves-Broughton, J.; Blackburn, P.; Evans, R. J.; Hugenholtz, J. (1996). "Applications of the bacteriocin, nisin". Antonie van ...
Thiostrepton
Kelly WL, Pan L, Li C (2009). "Thiostrepton biosynthesis: prototype for a new family of bacteriocins". J. Am. Chem. Soc. 131 ( ...
Biopreservation
These days LAB bacteriocins are used as an integral part of hurdle technology. Using them in combination with other ... LAB and their bacteriocins have been consumed unintentionally for ages, laying down a long history of safe use. Their ... Bacteriocins, bacteriophages and bacteriophage-encoded enzymes fall in this theory. The long and traditional role of Lactic ... As a product of its metabolism, it should also produce acids and other antimicrobial agents, particularly bacteriocins. ...
Secondary metabolite
Microcins, bacteriocins such as microcin V from Escherichia coli. Thiostrepton, from several strains of streptomycetes, e.g. ...
Streptomyces scopuliridis
nov., a bacteriocin-producing soil streptomycete". International Journal of Systematic and Evolutionary Microbiology. 61 (Pt 9 ... nov., a bacteriocin-producing soil streptomycete". International Journal of Systematic and Evolutionary Microbiology. 61 (Pt 9 ... Streptomyces scopuliridis produces bacteriocins, desotamides B, desotamides C, desotamides D, sesquiterpenoids and herbicidins ...
Latilactobacillus sakei
Bacteriocin genes are located either on chromosomes or on plasmids. Strain 5 produces a plasmid-encoded bacteriocin that is ... Sakacins are bacteriocins of class II produced by L. sakei. In strain CCUG 42687, their production is dependent on nutrients, ... The key elements of these vectors are a regulatable promoter involved in the production of the bacteriocins sakacin A and ... Lactocin S is a bacteriocin produced by strain L45 of Lactobacillus sakei. Strain 0-1 of L. sakei produces exopolysaccharides. ...
Lantibiotics
The lantibiotics are a class of more extensively modified bacteriocins, also called Class I bacteriocins. (Bacteriocins for ... they are considered a member of the bacteriocins. Bacteriocins are classified according to their extent of posttranslational ... Hammami R, Zouhir A, Ben Hamida J, Fliss I (2007). "BACTIBASE: a new web-accessible database for bacteriocin characterization ... BACTIBASE is an open-access database for bacteriocins including lantibiotics. LANTIBASE is a lantibiotic specific resource. ...
Lactobacillus gasseri
... produces gassericin A, a bacteriocin. Johnson, J. L.; Phelps, C. F.; Cummins, C. S.; London, J.; Gasser, ... 1]Pandey N, Malik RK, Kaushik JK, Singroha G (2013). "Gassericin A: a circular bacteriocin produced by lactic acid bacteria ...
Aeromonas media
It produces a bacteriocin-like inhibitory substance. Allen, D. A.; Austin, B.; Colwell, R. R. (1983). "Aeromonas media, a New ... Gibson, L.F. (1998). "Bacteriocin activity and probiotic activity of Aeromonas media". Journal of Applied Microbiology. 85 (S1 ...
Lactobacillus delbrueckii subsp. bulgaricus
Some strains of L. d. bulgaricus, such as L. bulgaricus GLB44, also produce bacteriocins, which have been shown to kill ... Simova, E. D.; Beshkova, D. M.; Angelov, M. P.; Dimitrov, Z. P. (2008). "Bacteriocin production by strain Lactobacillus ...
Peptide
Some microbes produce peptides as antibiotics, such as microcins and bacteriocins. Peptides frequently have post-translational ...
Microcin
... s are very small bacteriocins, composed of relatively few amino acids. For this reason, they are distinct from their ... Subtilosin A is another bacteriocin from Bacillus subtilis. The peptide has a cyclized backbone and forms three cross-links ... BACTIBASE database is an open-access database for bacteriocins including microcins. Kawulka KE, Sprules T, Diaper CM, Whittal ... a pore-forming bacteriocin". Cell Discovery. 7 (1): 20. doi:10.1038/s41421-021-00253-6. PMC 8021565. PMID 33820910.{{cite ...
Pyocin
... s are bacteriocins produced by bacteria belonging to the Pseudomonas genus. François Jacob described the first pyocin in ... S-type pyocins are colicin-like bacteriocins as R-type and F-type pyocins belong to tailocins. S-type (soluble) pyocins are ... Articles with short description, Short description is different from Wikidata, Bacteriocins). ...
Lactobacillus bulgaricus GLB44
Miteva V, Stefanova T, Budakov I, Ivanova I, Mitev V, Gancheva A, Ljubenov M (March 1998). "Characterization of bacteriocins ...
BAGEL: a web-based bacteriocin genome mining tool
This is particularly the case for bacteriocins, a very diverse group of antimicrobial peptides produced by bacteria and usually ... knowledge-based bacteriocin databases and motif databases. Many bacteriocins are encoded by small genes that are often omitted ... BAGEL: a web-based bacteriocin genome mining tool Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W273-9. doi: 10.1093/nar/ ... ORFs surrounding bacteriocin genes are often biosynthetic genes. This information can be used to locate putative structural ...
The role of bacteriocins in shaping oral biofilms | BOB Project | Fact Sheet | H2020 | CORDIS | European Commission
Bacteriocins are antimicrobial peptides produced by bacteria primarily known as... ... the role of bacteriocins in shaping oral biofilms will be investigated by moving a Spanish researcher currently working in ... The role of bacteriocins in biofilm formation. Bacteriocins are a group of antimicrobial peptides produced by bacteria as a ... Moreover, considering that bacteriocins have been suggested as potential alternatives to antibiotics in the future, project ...
Antifungal Activity of Bacteriocins of Lactic Acid Bacteria from Some Nigerian Fermented Foods
However, bacteriocins of all the LAB isolates with the exception of Lactobacillus plantarum EK1, L. plantarum EK4 and L. ... Bacteriocin is the most potent of all the antimicrobial compounds produced by Lactic Acid Bacteria (LAB). Bacteriocins are ... The bacteriocins of the LAB strains caused a reduction on the mycelia mass of P. citrinum and the effect of the different LAB ... Antifungal Activity of Bacteriocins of Lactic Acid Bacteria from Some Nigerian Fermented Foods. ...
Effective Pipetting for Bacteriocin Testing Workflows Labmate Online
We also do it the other way around, pipetting bacteria onto an agar containing the bacteriocin, to see whether or not they grow ... and activity testing of the antimicrobial bacteriocins produced via transient transformation. The preparation and dispensing of ... then we know our bacteriocins are active. ... Effective Pipetting for Bacteriocin Testing Workflows. Learn ...
Characterization of bacteriocin produced by Lactobacillus plantarum F1 and Lactobacillus brevis OG1
| African Journal of...
Comparison of the antimicrobial spectra and characterization of the two bacteriocins were not identical. Bacteriocin produced ... which led to total loss of bacteriocin activity. The bacteriocins were able to pass through cellulose membranes with 100,000 ... Characterization of bacteriocin produced by Lactobacillus plantarum F1 and Lactobacillus brevis OG1 * S.T. Ogunbanwo ... The bacteriocins produced by the test isolates maintained full stability after storage for 60 days at - 20°C; partial stability ...
Microbial production of bacteriocins and its applications in food preservation: A review.
Bacteriocins, a heterogeneous group of bioactive bacterial peptides or proteins, are ribosomally synthesized that inhibit or ... Classification of Bacteriocins. Bacteriocins are classified into different groups (Table 2). Class I bacteriocins (lantibiotics ... Table 6: Potential applications of bacteriocin in various formulations sector.. Bacteriocin Toxicity. Bacteriocins have been ... non-modified bacteriocins; class III, large (,10000) heat-labile bacteriocins; and class IV, complex bacteriocins, carrying ...
Constructing Social Reality Glossary - Annenberg Learner
Changes in cell surface and metabolism associated with strains of Listeria monocytogenes displaying different sensitivities to...
It is possible that this may result in reduced activity of the bacteriocin in resistant cell membranes as a-helical stucture is ... Mutants of the L. monocytogenes 873 isolate, resistant to the class IIa bacteriocin, leucocin A, were generated at the start of ... It is conceivable that more fluid membranes could also impact on decreased stability of pore formation by the bacteriocin. ... The high frequencies of resistance to class Ha bacteriocins have however sparked concern regarding their adequacy as potential ...
Synergy between circular bacteriocin AS-48 and ethambutol against mycobacterium tuberculosis - GHTM
Synergy between circular bacteriocin AS-48 and ethambutol against mycobacterium tuberculosis. *Autores: Aguilar-Pérez C, Garcia ... In summary, bacteriocin AS-48 has an interesting antimycobacterial activity in vitro and low cytotoxicity, so further studies ... Bacteriocin AS-48 is an antibacterial peptide produced by Enterococcus faecalis, active against several Gram-positive bacteria ... Synergy between circular bacteriocin AS-48 and ethambutol against mycobacterium tuberculosis. ...
Bacteriocin-encoding genes and ExPEC virulence determinants are associated in human fecal Escherichia coli strains | BMC...
Bacteriocin synthesis appears to modulate the ability of E. coli strains to reside in the human intestine and/or the virulence ... The occurrence of bacteriocin-encoding genes was found to be positively correlated with the occurrence of E. coli virulence ... The occurrence of bacteriocin-encoding genes and ExPEC virulence determinants correlate positively in E. coli strains of human ... Altogether, 17 virulence determinants and 31 bacteriocin-encoding genes were tested in each of them. ...
View of Antibacterial activity of bacteriocin produced by Bacillus velezensis BUU004, herb extracts and their combination for...
EN (en)
Bacteriocin from epidemic Listeria strains alters the host intestinal microbiota to favor infection.. ... To our knowledge, these results therefore identify LLS as the first bacteriocin described in L. monocytogenes and associate ... Listeriolysin S is a bacteriocin specifically produced in the intestine of orally infected mice and necessary for Listeria ... is a bacteriocin highly expressed in the intestine of orally infected mice that alters the host intestinal microbiota and ...
Download Bacteriocins: Ecology And Evolution 2007
JoF | Free Full-Text | Candida spp./Bacteria Mixed Biofilms
IMSEAR at SEARO: Bacteriocin production in Salmonella.
peptalk-2017 - Syngulon - Bacteriocin-based technologies
Bivariate Data and Analysis Glossary - Annenberg Learner
H. Abriouel | Semantic Scholar
Application of bacteriocins in the control of foodborne pathogenic and spoilage bacteria.. *A. Gálvez, R. López, H. Abriouel, E ... Bacteriocin-based strategies for food biopreservation.. *A. Gálvez, H. Abriouel, R. López, N. ben Omar ... Diversity of enterococcal bacteriocins and their grouping in a new classification scheme.. *C. Franz, M. V. van Belkum, W. ... Diversity and applications of Bacillus bacteriocins.. *H. Abriouel, C. Franz, N. ben Omar, A. Gálvez ...
bacteriocin Archives - International Scientific Association for Probiotics and Prebiotics (ISAPP)
This month, ISAPP board member and former president Professor Colin Hill received a prestigious award from University College Cork (Ireland), where he has worked since 1992: The UCC Career Achievement Research Award. The prize honours leading researchers whose influential work has been recognized globally.. Hills research interests lie in molecular microbiology-specifically, issues around infection. His team was the first to discover lacticin 3147 and thuricin CD, two examples of a class of anti-microbials produced by bacteria that kill bacteria. He is also a leading scientist exploring the human virome: his team developed tools for gut virome analysis, performed phage therapy in vivo, and increased the number of known phage genomes by tens of thousands. Hill is the inventor on 23 patents, has published over 570 research articles, and to date, has secured over €25 million worth of research funding. His publications and citations put him in the top 1% of researchers worldwide.. Hill has served ...
Frontiers | Colicins and Salmocins - New Classes of Plant-Made Non-antibiotic Food Antibacterials
Potential Markets for Bacteriocins as Food Antibacterials. Bacteriocins such as colicins and salmocins are promising ... Table 1. Bacteriocins versus antibiotics: major biological differences and market potential of bacteriocins. ... 2018). Plant-made Salmonella bacteriocins salmocins for control of Salmonella pathovars. Sci. Rep. 8:4078. doi: 10.1038/s41598- ... The generation of bacteriocin-transgenic N. benthamiana was published in Schulz et al. (2015) and Schneider et al. (2018). ...
Inhibitory effect of streptococci on the growth of M. catarrhalis strains and the diversity of putative bacteriocin-like gene...
We observed that a set of bacteriocin-like genes in the genome of S. mitis is greatly poorer in comparison with S. pneumoniae ... so we examined the genomes of our strains for the presence of bacteriocin-like peptides encoding genes. ... one; moreover, in one S. mitis strain we found no bacteriocin-like genes. It could mean that there are probably some additional ... From: Inhibitory effect of streptococci on the growth of M. catarrhalis strains and the diversity of putative bacteriocin-like ...
Table - 15th International Workshop on Campylobacter, Helicobacter and Related Organisms - Volume 16, Number 7-July 2010 -...
Bacteriocin reduces colonization. Hanan et al. (10). Lytic bacteriophage therapy. UK. 2 log reduction in cecal levels of birds. ... Use of bacteriocins. USA. 5-6 log reduction in cecal contents, 3 d prior to slaughter. Svetoch and Stern (7). ... Potentials for bacteriocin development to control Campylobacter in broilers. In: Proceedings of the 15th International Workshop ...
Bacterial Secretome Analysis in Hunt for Novel Bacteriocins with Ability to Control Xanthomonas citri subsp. Citri
Results: The two bacteriocins showed an activity up to 55ºC that were sensitive to proteases suggesting being protein in nature ... Varieties of means have been used to minimize its devastating effects, but no attention has been given to bacteriocins. ... Objectives: Here and for the first time, we report the isolation and characterization of two novel bacteriocins. Materials and ... The effects of varieties of carbon, nitrogen and phosphate sources were evaluated on both bacterial growth and bacteriocin ...
Publication : USDA ARS
The presence of nisin, a food grade bacteriocin approved for human consumption, was required for optimum bacteriocin production ... Some LAB are unable to grow in milk because they cannot use lactose, but dairy LAB can be made to produce bacteriocins as ... In this study, we developed a way to introduce a bacteriocin, which inhibits the growth of Listeria, into dairy LAB such as ... Bacteriocin expression was shown to effectively inhibit the growth of the food pathogen Listeria monocytogenes. These results ...
Advances in Fermented Foods and Beverages - 1st Edition
Genomic analyses of pneumococci reveal a wide diversity of bacteriocins - including pneumocyclicin, a novel circular...
RESULTS: We found that all genomes maintained a blp bacteriocin cassette and we identified several novel blp cassettes and ... The composition of the bacteriocin/immunity region of the blp cassette was highly variable: one cassette possessed six ... Most surprisingly, one-third of pneumococcal genomes also possessed a cassette encoding a novel circular bacteriocin that we ... CONCLUSIONS: These detailed genomic analyses revealed a novel pneumocyclicin cassette and a wide variety of blp bacteriocin ...
IUCr) Acta Crystallographica Section D Volume 60, Part 10, October 2004
Transcriptomic and proteomic profiling response of methicillin-resistant Staphylococcus aureus (MRSA) to a novel bacteriocin,...
BacteriaCharacterizationPutativeSalmonellaBacillusNovel bacteriocinsPreservativesAntibacterialPeptidesNisinGenesAntibioticsProteinsStrainsProbioticsPediocinInhibitory effectGenomicProteinaceousBiofilm formationListeriaEncapsulationProductionGeneDiversityVirulenceMonocytogenesCircularActivityStreptococcusSynthesisInteractionsSubstancePotentialProducerStabilityEffect
Bacteria21
- This is particularly the case for bacteriocins, a very diverse group of antimicrobial peptides produced by bacteria and usually encoded by small, poorly conserved ORFs. (nih.gov)
- Bacteriocins are a group of antimicrobial peptides produced by bacteria as a protection strategy against other bacteria. (europa.eu)
- By combining experimental methods and bioinformatics, researchers will explore the role of bacteriocin immunity genes in bacteria interacting during biofilm formation. (europa.eu)
- This study was conducted to evaluate the antifungal activity of bacteriocins of lactic acid bacteria from some Nigerian fermented foods (Eko, Fufu, Iru and Ogi). (scialert.net)
- Screening of 25 bacteriocin-producing Lactic Acid Bacteria (LAB) isolated from Eko, Fufu, Iru and Ogi against three spoilage fungi ( Penicillium citrinum , Aspergillus niger and A. flavus) associated with stored fermented foods revealed that 68% of the isolates possessed antifungal activity. (scialert.net)
- We do a 'spot-on-lawn' assay where we pipette drops of our peptide solutions onto bacteria grown on agar gel in square petri dishes (12 x 12 cm) and, if the bacteria are killed, then we know our bacteriocins are active. (labmate-online.com)
- We also do it the other way around, pipetting bacteria onto an agar containing the bacteriocin, to see whether or not they grow. (labmate-online.com)
- Lactobacillus plantarum F1 and L. brevis OG1 isolated from Nigerian fermented food products, produced bacteriocins that had broad spectrum of inhibition against both pathogenic, food spoilage organisms and various lactic acid bacteria. (ajol.info)
- The paper concluded that the ability of bacteriocins produced by the test isolates in inhibiting a wide-range of bacteria, is of potential interest for food safety and may have future applications as food preservative. (ajol.info)
- Bacteriocins are a large family of ribosomally synthesized proteinaceous toxins produced by bacteria and Archaea that have antimicrobial activity against bacteria closely related to the producer strain [ 9 ]. (alliedacademies.org)
- The cell envelope (cell wall and cell membrane) is therefore envisaged as a key site of modification in suscepti bility of bacteria to class Ha bacteriocins. (sun.ac.za)
- Bacteriocin AS-48 is an antibacterial peptide produced by Enterococcus faecalis , active against several Gram-positive bacteria. (unl.pt)
- Application of bacteriocins in the control of foodborne pathogenic and spoilage bacteria. (semanticscholar.org)
- Materials and Methods: Secretome containing bacteriocins of isolated bacteria was separated via SDS-PAGE. (ijbiotech.com)
- Ribosomally synthesized antimicrobial peptides also known as bacteriocins with detrimental effect on limited bacterial host range can play an important role in the biocontrol of plant pathogenic bacteria species (2, 3). (ijbiotech.com)
- Fortunately, some lactic acid bacteria (LAB) considered safe for human consumption have been shown to produce peptides, short proteins called bacteriocins, which inhibit the growth of other bacteria including foodborne pathogens. (usda.gov)
- Pneumococci reside in the paediatric nasopharynx, where they compete for space and resources, and one competition strategy is to produce a bacteriocin (antimicrobial peptide or protein) to attack other bacteria and an immunity protein to protect against self-destruction. (ox.ac.uk)
- Survival of bacteriocins and probiotic bacteria in vivo is studied using mice and rats as models. (sun.ac.za)
- Characterization of novel bacteriocins produced by lactic acid bacteria. (sun.ac.za)
- The study of antimicrobial bacteriocins produced by agrobacteria within host plants is a crucial research area for NOMAD, and the company works with various bacteria, including Klebsiella, Pseudomonas, Clostridia, Escherichia coli and Salmonella. (integra-biosciences.com)
- Bacteriocins are antimicrobial peptides produced by bacteria to inhibit competitors in their natural environments. (dtu.dk)
Characterization5
- Comparison of the antimicrobial spectra and characterization of the two bacteriocins were not identical. (ajol.info)
- This article gives an overview of the classification of bacteriocins, isolation and characterization, and mode of action. (alliedacademies.org)
- The present review provides a general overview of Bacillus bacteriocins, including primary structure, biochemical and genetic characterization, classification and potential applications in food preservation as natural preservatives and in human and animal health as alternatives to conventional antibiotics. (semanticscholar.org)
- Objectives: Here and for the first time, we report the isolation and characterization of two novel bacteriocins. (ijbiotech.com)
- Characterization of bacteriocins produced by Carnobacterium maltaromaticum C2, isolated. (usp.br)
Putative4
- This information can be used to locate putative structural bacteriocin genes. (nih.gov)
- Here, we describe BAGEL, a web server that identifies putative bacteriocin ORFs in a DNA sequence using novel, knowledge-based bacteriocin databases and motif databases. (nih.gov)
- These innovations make BAGEL unique in its ability to detect putative bacteriocin gene clusters in (new) bacterial genomes. (nih.gov)
- The composition of the 'bacteriocin/immunity region' of the blp cassette was highly variable: one cassette possessed six bacteriocin genes and eight putative immunity genes, whereas another cassette had only one of each. (ox.ac.uk)
Salmonella2
Bacillus1
- Diversity and applications of Bacillus bacteriocins. (semanticscholar.org)
Novel bacteriocins1
- Bacterial Secretome Analysis in Hunt for Novel Bacteriocins with Ability to Control Xanthomonas citri subsp. (ijbiotech.com)
Preservatives4
- Since they pose no health risk concerns, soon bacteriocins are largely dependent on their use as safe food preservatives. (alliedacademies.org)
- ENGLISH ABSTRACT: The possible use of the bacterially produced antimicrobial peptides, and in particular class IIa bacteriocins as food preservatives is a motivating factor in studies on resistance to them by food-borne pathogens like Listeria monocytogenes. (sun.ac.za)
- Application of bacteriocins may help reduce the use of chemical preservatives and/or the intensity of heat and other physical treatments, satisfying the demands of consumers for foods that are fresh tasting, ready to eat, and lightly preserved. (semanticscholar.org)
- Some LAB are unable to grow in milk because they cannot use lactose, but dairy LAB can be made to produce bacteriocins as natural preservatives in fermented dairy products. (usda.gov)
Antibacterial1
- Exceptionally few bacteriocins along with their native antibacterial property also exhibit additional anti-viral and antifungal properties [ 10 ]. (alliedacademies.org)
Peptides4
- Bacteriocins, a heterogeneous group of bioactive bacterial peptides or proteins, are ribosomally synthesized that inhibit or kill other related or unrelated microorganisms. (alliedacademies.org)
- It is possible that this may result in reduced activity of the bacteriocin in resistant cell membranes as a-helical stucture is a critical feature for membrane insertion of cationic antimicrobial peptides. (sun.ac.za)
- Isolates are screened for the production of novel antimicrobial peptides (bacteriocins) and also selected for probiotic properties. (sun.ac.za)
- This allows expression of the target bacteriocin peptides in the plant, which is followed by peptide purification downstream studies to investigate the antimicrobial activities of the bacteriocins that are obtained. (integra-biosciences.com)
Nisin2
- The presence of nisin, a food grade bacteriocin approved for human consumption, was required for optimum bacteriocin production. (usda.gov)
- Under carbohydrate starvation stress, we investigated the generation of non-culturable forms of three bacteriocin (nisin) producing Lactococcus lactis subsp. (2pressrelease.net)
Genes6
- ORFs surrounding bacteriocin genes are often biosynthetic genes. (nih.gov)
- Many bacteriocins are encoded by small genes that are often omitted in the annotation process of bacterial genomes. (nih.gov)
- In addition, BAGEL takes into account the genomic context, i.e. for each potential bacteriocin-encoding ORF, the sequence of the surrounding region on the genome is analyzed for genes that might encode proteins involved in biosynthesis, transport, regulation and/or immunity. (nih.gov)
- They are found in gene clusters that encompass genes involved in bacteriocin production, immunity and transport. (europa.eu)
- RESULTS: We found that all genomes maintained a blp bacteriocin cassette and we identified several novel blp cassettes and genes. (ox.ac.uk)
- Genes encoding bacteriocin production, and adhesion to epithelial cells and mucus layers are sequenced and expressed in different bacterial hosts. (sun.ac.za)
Antibiotics3
- Moreover, considering that bacteriocins have been suggested as potential alternatives to antibiotics in the future, project results will have important consequences for the healthcare sector. (europa.eu)
- Use of microbial exudates including but not limited to antibiotics, proteinaceous exotoxins, lysozymes, and bacteriocins (1) may reduce the population of bacterial pathogens during seasonal outbreak. (ijbiotech.com)
- Microorganisms residing within biofilms are highly resistant to antimicrobials including antibiotics and bacteriocins produced by probiotics. (revelationhealth.com)
Proteins1
- The scope of the EU-funded BOB project is to map bacteriocin gene clusters with associated immunity proteins in oral streptococci. (europa.eu)
Strains5
- In addition, treatment with a desaturase inhibitor resulted in increased sensitivity of only the intermediate resistant strains to the class na bacteriocin, leucocin A. This indicated the influence of membrane adaptation in only lower levels of resistance. (sun.ac.za)
- Bacteriocin from epidemic Listeria strains alters the host intestinal microbiota to favor infection. (pasteur.fr)
- Here, we demonstrate that Listeriolysin S (LLS), a virulence factor only present in a subset of lineage I strains, is a bacteriocin highly expressed in the intestine of orally infected mice that alters the host intestinal microbiota and promotes intestinal colonization by L. monocytogenes, as well as deeper organ infection. (pasteur.fr)
- To our knowledge, these results therefore identify LLS as the first bacteriocin described in L. monocytogenes and associate modulation of host microbiota by L. monocytogenes epidemic strains to increased virulence. (pasteur.fr)
- Similarity of bacteriocin activity profi les of mutans streptococci within the family when the children acquire the strains after the age of 5. (bvsalud.org)
Probiotics2
- The interventions reported at the meeting were largely for adoption in industrialized nations and followed the themes of biosecurity, use of bacteriophages, bacteriocins, probiotics, antimicrobial drugs, and vaccination and reported varying degrees of success. (cdc.gov)
- Both the LactORN and the No.7 Systemic Booster contain ingredients that challenge our immune system-namely, the oligoribonucleotides (ORNs) and the supernatant broth (whole dead-cells of probiotics, vitamins & minerals, enzymes, bacteriocin, ORNs, and more), respectively. (bioimmersion.com)
Pediocin5
- Here, we identify Corynebacterium glutamicum as a suitable production host for the bacteriocin pediocin PA-1. (dtu.dk)
- C. glutamicum CR099 shows resistance to high concentrations of pediocin PA-1 and the bacteriocin was not inactivated when spiked into growing cultures of this bacterium. (dtu.dk)
- Overall, we demonstrate that C. glutamicum is a suitable host for recombinant production of bacteriocins of the pediocin family. (dtu.dk)
- The bacteriocin pediocin PA-1 has potential use as a food biopreservative, and understanding its effect on the commensal gut microbiota is important for assessment of consumer risks associated with the use of biopreservative cultures. (dtu.dk)
- Pediocin PA-1 did not mediate changes of the rat microbiota, and a biological assay indicated that the bacteriocin was degraded or inactivated during passage through the intestine. (dtu.dk)
Inhibitory effect2
- The inhibitory effect of the bacteriocins on spore germination of P. citrinum ranged from 2.44 to 85.36% in Lactobacillus casei FF1 and L. brevis SG1, respectively. (scialert.net)
- Recombinant CBM 588 bacteriocin (CBM-B) was constructed and demonstrated to have inhibitory effect against C. difficile . (okstate.edu)
Genomic2
- Genomic analyses of pneumococci reveal a wide diversity of bacteriocins - including pneumocyclicin, a novel circular bacteriocin. (ox.ac.uk)
- CONCLUSIONS: These detailed genomic analyses revealed a novel pneumocyclicin cassette and a wide variety of blp bacteriocin cassettes, suggesting that competition in the nasopharynx is a complex biological phenomenon. (ox.ac.uk)
Proteinaceous1
- Their active principle was proteinaceous in nature since the bacteriocins were inactivated by proteolytic enzymes, but not by other non-proteolytic enzymes. (ajol.info)
Biofilm formation1
- Transcriptomic and proteomic profiling response of methicillin-resistant Staphylococcus aureus (MRSA) to a novel bacteriocin, plantaricin GZ1-27 and its inhibition of biofilm formation. (bvsalud.org)
Listeria3
- Listeriolysin S is a bacteriocin specifically produced in the intestine of orally infected mice and necessary for Listeria monocytogenes survival in this organ. (pasteur.fr)
- In this study, we developed a way to introduce a bacteriocin, which inhibits the growth of Listeria, into dairy LAB such as Streptococcus thermophilus, Lactococcus lactis and Lactobacillus casei. (usda.gov)
- Bacteriocin expression was shown to effectively inhibit the growth of the food pathogen Listeria monocytogenes. (usda.gov)
Encapsulation2
Production5
- Microbial production of bacteriocins and its applications in food preservation: A review. (alliedacademies.org)
- Garai B, Purkait A, Ghose T ,et al.Microbial production of bacteriocins and its applications in food preservation: A review. (alliedacademies.org)
- The effects of varieties of carbon, nitrogen and phosphate sources were evaluated on both bacterial growth and bacteriocin production via Taguchi orthogonal method. (ijbiotech.com)
- A Taguchi orthogonal array was also implemented to determine the effect of temperature and eight other chemical factors on bacteriocin production for each bacterium. (ijbiotech.com)
- Following isolation of bacteriocins, the bacterial culture media were optimized towards faster bacterial growth and higher bacteriocin production. (ijbiotech.com)
Gene1
- The plasmid insertion conferring the antilisterial-peptide- negative phenotype was located in a seven-gene operon (alb, for antilisterial bacteriocin) residing immediately downstream from the sbo gene, which encodes the precursor of subtilosin. (elsevier.com)
Diversity2
- Diversity of enterococcal bacteriocins and their grouping in a new classification scheme. (semanticscholar.org)
- We analysed a collection of 336 diverse pneumococcal genomes dating from 1916 onwards, identified bacteriocin cassettes, detailed their genetic composition and sequence diversity, and evaluated the data in the context of the pneumococcal population structure. (ox.ac.uk)
Virulence1
- Correspondence analysis for bacteriocin types and virulence factors. (biomedcentral.com)
Monocytogenes1
- Mutants of the L. monocytogenes 873 isolate, resistant to the class IIa bacteriocin, leucocin A, were generated at the start of the study to complement the existing array of L. monocytagenes wild-type and resistant isolates obtained from other sources. (sun.ac.za)
Circular2
- including pneumocyclicin, a novel circular bacteriocin. (ox.ac.uk)
- Most surprisingly, one-third of pneumococcal genomes also possessed a cassette encoding a novel circular bacteriocin that we called pneumocyclicin, which shared a similar genetic organisation to well-characterised circular bacteriocin cassettes in other bacterial species. (ox.ac.uk)
Activity6
- Research scientist Birgit Koch explained how she uses the VOYAGER in her work: "My research is focused on molecular cloning, to generate plant virus-based expression vectors that are transferred using agrobacteria into the host plants, and activity testing of the antimicrobial bacteriocins produced via transient transformation. (labmate-online.com)
- while activity was not detected after storage for 80 to 120 days at 37°C. Bacteriocin produced by L. brevis OG1 was stable at pH range of 2.0 to 8.0 while, that of L. plantarum F1 was found to be stable at pH 2.0 to 6.0. (ajol.info)
- mitomycin C and uv light did not affect the activity of the bacteriocins, while chloroform extraction completely destroyed their activity. (ajol.info)
- Exposure to surfactant resulted in an increase in the bacteriocin titre, except Nonidet P-40, which led to total loss of bacteriocin activity. (ajol.info)
- In summary, bacteriocin AS-48 has an interesting antimycobacterial activity in vitro and low cytotoxicity, so further studies in vivo will contribute to its development as a potential additional drug for antituberculosis therapy. (unl.pt)
- Results: The two bacteriocins showed an activity up to 55ºC that were sensitive to proteases suggesting being protein in nature. (ijbiotech.com)
Streptococcus1
- detection of bacteriocin-like inhibitory substance against streptococcus mutans. (ukm.my)
Synthesis1
- Comparison of the presubtilosin and mature subtilosin sequences suggested that certain residues undergo unusual posttranslational modifications unlike those occurring during the synthesis of class I (lantibiotic) or some class II bacteriocins. (elsevier.com)
Interactions1
- This neutralisation of the negative charge of the cell surface may interfere with initial electrostatic interaction of bacteriocin with the cell, and subsequent interactions required for permeabilisation of the cell membrane. (sun.ac.za)
Substance1
- Amino acid analysis confirmed that the substance was the cyclic bacteriocin subtilosin. (elsevier.com)
Potential2
- Besides, this article stated the potential applications of bacteriocin in the bactericidal formulations sector. (alliedacademies.org)
- The high frequencies of resistance to class Ha bacteriocins have however sparked concern regarding their adequacy as potential biopreservatives. (sun.ac.za)
Producer1
- Currently, commercial bacteriocins are produced exclusively with natural producer organisms on complex substrates and are sold as semi-purified preparations or crude fermentates. (dtu.dk)
Stability1
- It is conceivable that more fluid membranes could also impact on decreased stability of pore formation by the bacteriocin. (sun.ac.za)
Effect1
- Another project focuses on the effect bacteriocins may have on cancer cells. (sun.ac.za)