A complex of proteins that forms a receptor for TRANSFERRIN in BACTERIA. Many pathogenic bacteria utilize the transferrin-binding complex to acquire their supply of iron from serum.
A group of iron-binding proteins that tightly bind two ferrate ions along with two carbonate ions. They are found in the bodily fluids of vertebrates where they act as transport and storage molecules for iron.
Membrane glycoproteins found in high concentrations on iron-utilizing cells. They specifically bind iron-bearing transferrin, are endocytosed with its ligand and then returned to the cell surface where transferrin without its iron is released.
An iron-binding beta1-globulin that is synthesized in the LIVER and secreted into the blood. It plays a central role in the transport of IRON throughout the circulation. A variety of transferrin isoforms exist in humans, including some that are considered markers for specific disease states.
A species of gram-negative, aerobic BACTERIA. It is a commensal and pathogen only of humans, and can be carried asymptomatically in the NASOPHARYNX. When found in cerebrospinal fluid it is the causative agent of cerebrospinal meningitis (MENINGITIS, MENINGOCOCCAL). It is also found in venereal discharges and blood. There are at least 13 serogroups based on antigenic differences in the capsular polysaccharides; the ones causing most meningitis infections being A, B, C, Y, and W-135. Each serogroup can be further classified by serotype, serosubtype, and immunotype.
A fulminant infection of the meninges and subarachnoid fluid by the bacterium NEISSERIA MENINGITIDIS, producing diffuse inflammation and peri-meningeal venous thromboses. Clinical manifestations include FEVER, nuchal rigidity, SEIZURES, severe HEADACHE, petechial rash, stupor, focal neurologic deficits, HYDROCEPHALUS, and COMA. The organism is usually transmitted via nasopharyngeal secretions and is a leading cause of meningitis in children and young adults. Organisms from Neisseria meningitidis serogroups A, B, C, Y, and W-135 have been reported to cause meningitis. (From Adams et al., Principles of Neurology, 6th ed, pp689-701; Curr Opin Pediatr 1998 Feb;10(1):13-8)
Infections with bacteria of the species NEISSERIA MENINGITIDIS.
Strains of Neisseria meningitidis which are the most common ones causing infections or disease in infants. Serogroup B strains are isolated most frequently in sporadic cases, and are less common in outbreaks and epidemics.
Strains of Neisseria meningitidis responsible for most sporadic cases in teenagers and almost all outbreaks of disease in this age group. These strains are less common in infants.
Strains of Neisseria meningitidis found mostly in Africa.
Strains of Neisseria meningitidis responsible for most outbreaks of meningococcal disease in Western Europe and the United States in the first half of the 20th century. They continue to be a major cause of disease in Asia and Africa, and especially localized epidemics in Sub-Sahara Africa.

Construction and characterization of Moraxella catarrhalis mutants defective in expression of transferrin receptors. (1/4)

We have previously reported the construction of an isogenic mutant defective in expression of OmpB1, the TbpB homologue, in Moraxella catarrhalis 7169. In this report, we have extended these studies by constructing and characterizing two new isogenic mutants in this clinical isolate. One mutant is defective in expression of TbpA, and the other mutant is defective in expression of both TbpA and TbpB. These isogenic mutants were confirmed by using PCR analysis, sodium dodecyl sulfate-polyacrylamide gel electrophoresis, and sequencing. In vitro growth studies, comparing all three mutants, demonstrated that the tbpA mutant and the tbpAB mutant were severely limited in their ability to grow with human holotransferrin as the sole source of iron. In contrast, the ompB1 (tbpB) mutant was capable of utilizing iron from human transferrin, although not to the extent of the parental strain. While affinity chromatography with human holotransferrin showed that each Tbp was capable of binding independently to transferrin, solid-phase transferrin binding studies using whole cells demonstrated that the tbpA mutant exhibited binding characteristics similar to those seen with the wild-type bacteria. However, the ompB1 (tbpB) mutant exhibited a diminished capacity for binding transferrin, and no binding was detected with the double mutant. These data suggest that the M. catarrhalis TbpA is necessary for the acquisition of iron from transferrin. In contrast, TbpB is not essential but may serve as a facilitory protein that functions to optimize this process. Together these mutants are essential to provide a more thorough understanding of iron acquisition mechanisms utilized by M. catarrhalis.  (+info)

Staphylococcus aureus siderophore-mediated iron-acquisition system plays a dominant and essential role in the utilization of transferrin-bound iron. (2/4)

Staphylococcus aureus is known to be capable of utilizing transferrin-bound iron, via both siderophore- and transferrin-binding protein (named IsdA)-mediated iron-acquisition systems. This study was designed in order to determine which iron-acquisition system plays the essential or dominant role with respect to the acquisition of iron from human transferrin, in the growth of S. aureus. Holotransferrin (HT) and partially iron-saturated transferrin (PT), but not apotransferrin (AT), were found to stimulate the growth of S. aureus. S. aureus consumed most of the transferrin-bound iron during the exponential growth phase. Extracellular proteases were not, however, involved in the liberation of iron from transferrin. Transferrin-binding to the washed whole cells via IsdA was not observed during the culture. The expression of IsdA was observed only in the deferrated media with AT, but not in the media supplemented with PT or HT. In contrast, siderophores were definitely produced in the deferrated media with PT and HT, as well as in the media supplemented with AT. The siderophores proved to have the ability to remove iron directly from transferrin, but the washed whole cells expressing IsdA did not. In the bioassay, the growth of S. aureus on transferrin-bound iron was stimulated by the siderophores alone. These results demonstrate that the siderophore-mediated iron-acquisition system plays a dominant and essential role in the uptake of iron from transferrin, whereas the IsdA-mediated iron-acquisition system may play only an ancillary role in the uptake of iron from transferrin.  (+info)

FbpA--a bacterial transferrin with more to offer. (3/4)

 (+info)

Use of an isogenic mutant constructed in Moraxella catarrhalis To identify a protective epitope of outer membrane protein B1 defined by monoclonal antibody 11C6. (4/4)

Moraxella catarrhalis-induced otitis media continues to be a significant cause of infection in young children, prompting increased efforts at identifying effective vaccine antigens. We have previously demonstrated that M. catarrhalis expresses specific outer membrane proteins (OMPs) in response to iron limitation and that this organism can utilize transferrin and lactoferrin for in vitro growth. One of these proteins, which binds human transferrin, is OMP B1. As the human host presents a naturally iron-limited environment, proteins, like OMP B1, which are expressed in response to this nutritional stress are potential vaccine antigens. In this study, we have developed monoclonal antibody (MAb) 11C6, which reacts to a surface-exposed epitope of OMP B1 expressed by M. catarrhalis 7169. This antibody was used to clone ompB1, and sequence analysis suggested that OMP B1 is the M. catarrhalis homologue to the transferrin binding protein B described for pathogenic Neisseriaceae, Haemophilus influenzae, Actinobacillus pleuropneumoniae, and M. catarrhalis. Expression of recombinant OMP B1 on the surface of Escherichia coli confers transferrin binding activity, confirming that this protein is likely involved in iron acquisition. In addition, ompB1 was used to construct an isogenic mutant in M. catarrhalis 7169. This mutant, termed 7169b12, was used as the control in bactericidal assays designed to determine if OMP B1 elicits protective antibodies. In the presence of MAb 11C6 and human complement, wild-type 7169 demonstrated a 99% decline in viability, whereas the ompB1 isogenic mutant was resistant to this bactericidal activity. Further analysis with MAb 11C6 revealed the presence of this OMP B1 epitope on 31% of the clinical isolates tested. These data suggest that OMP B1 is a potential vaccine antigen against M. catarrhalis infections.  (+info)

The Bacterial Transferrin Receptor Complex (BTRC) is a protein complex that plays a role in the uptake of iron by bacteria. It is composed of two proteins, transferrin receptor (TfR) and ferric uptake regulator (Fur), which work together to facilitate the uptake of iron from the host environment. TfR is a membrane protein that binds to iron-bound transferrin, a protein that carries iron in the bloodstream. When TfR binds to iron-bound transferrin, it triggers a signaling cascade that leads to the internalization of the iron-bound transferrin-TfR complex into the bacterial cell. Fur, on the other hand, is a transcriptional regulator that controls the expression of genes involved in iron uptake. When iron levels are low, Fur binds to the promoter regions of these genes, preventing their transcription and reducing iron uptake. When iron levels are high, Fur dissociates from the promoter regions, allowing the genes to be transcribed and increasing iron uptake. The BTRC is important for the survival of many pathogenic bacteria, as iron is a critical nutrient for bacterial growth and metabolism. Understanding the structure and function of the BTRC is important for the development of new antibiotics and other therapies to combat bacterial infections.

Transferrins are a group of proteins that play a crucial role in the transport of iron in the body. There are two main types of transferrins: serum transferrin and lactoferrin. Serum transferrin is the most abundant transferrin in the blood plasma and is responsible for transporting iron from the diet to the body's cells. It binds to iron ions in the bloodstream and delivers them to cells that need iron for various metabolic processes. Lactoferrin is found in high concentrations in breast milk and is also present in other bodily fluids such as tears, saliva, and mucous. It has antimicrobial properties and helps protect against infections. Lactoferrin also plays a role in iron transport, although its function is different from that of serum transferrin. Transferrins are important for maintaining healthy iron levels in the body and preventing iron deficiency anemia. Abnormalities in transferrin levels or function can lead to various medical conditions, including anemia, iron overload, and certain types of cancer.

Receptors, Transferrin are proteins that are found on the surface of cells and are responsible for binding to the iron transport protein transferrin, which carries iron in the bloodstream. These receptors play a crucial role in regulating the uptake of iron by cells and are involved in a number of physiological processes, including the production of red blood cells and the maintenance of iron homeostasis in the body. In the medical field, the study of transferrin receptors is important for understanding the mechanisms of iron metabolism and for developing treatments for iron-related disorders, such as anemia and iron overload.

Transferrin is a plasma protein that plays a crucial role in the transport of iron in the bloodstream. It is synthesized in the liver and transported to the bone marrow, where it helps to regulate the production of red blood cells. Transferrin also plays a role in the immune system by binding to and transporting iron to immune cells, where it is used to produce antibodies. In the medical field, low levels of transferrin can be a sign of iron deficiency anemia, while high levels may indicate an excess of iron in the body.

Meningitis, Meningococcal is a serious bacterial infection that affects the protective membranes (meninges) surrounding the brain and spinal cord. It is caused by the bacterium Neisseria meningitidis, which can spread through close contact with an infected person's respiratory secretions, such as saliva or mucus. The symptoms of meningococcal meningitis can include fever, headache, stiff neck, sensitivity to light, nausea and vomiting, and a rash. In severe cases, the infection can lead to seizures, coma, and even death. Meningococcal meningitis is a medical emergency and requires prompt treatment with antibiotics. Vaccines are available to prevent the disease, and it is recommended for certain high-risk groups, such as adolescents and young adults, and people with certain medical conditions or who live in close quarters with others.

Meningococcal infections are a group of bacterial infections caused by Neisseria meningitidis, a type of bacteria that can cause meningitis (inflammation of the lining of the brain and spinal cord) and sepsis (blood poisoning). The bacteria can also cause infections of the skin, joints, and other body tissues. Meningococcal infections can be life-threatening if left untreated. Symptoms of meningococcal meningitis can include fever, headache, stiff neck, sensitivity to light, and a rash. Symptoms of meningococcal sepsis can include fever, chills, rapid heartbeat, and confusion. There are several types of meningococcal vaccines available that can help prevent meningococcal infections. These vaccines are recommended for certain high-risk groups, such as infants, children, and young adults. If you suspect you or someone you know may have a meningococcal infection, it is important to seek medical attention immediately.

... bacterial transferrin receptor complex MeSH D12.776.157.905.500.249.500 - transferrin-binding protein a MeSH D12.776.157.905. ... tnf receptor-associated factor 1 MeSH D12.776.157.057.500.750 - tnf receptor-associated factor 2 MeSH D12.776.157.057.500.875 ... tnf receptor-associated factor 3 MeSH D12.776.157.057.500.937 - tnf receptor-associated factor 5 MeSH D12.776.157.057.500.968 ... electron transport complex i MeSH D12.776.157.530.450.250.875.468 - electron transport complex iii MeSH D12.776.157.530.450.250 ...
... bacterial transferrin receptor complex MeSH D12.776.543.750.850.249.500 - transferrin-binding protein a MeSH D12.776.543.750. ... receptor-cd3 complex, antigen, t-cell MeSH D12.776.543.750.705.816.824.825 - receptors, antigen, t-cell, alpha-beta MeSH ... receptor, erbb-2 MeSH D12.776.543.750.060.437 - receptor, erbb-3 MeSH D12.776.543.750.060.468 - receptor, igf type 1 MeSH ... receptor, igf type 1 MeSH D12.776.543.750.750.400.780.410 - receptor, igf type 2 MeSH D12.776.543.750.750.400.820 - receptors, ...
... bound to its receptor. Transferrin receptor complex. Transferrin is also associated with the innate immune system. ... It is found in the mucosa and binds iron, thus creating an environment low in free iron that impedes bacterial survival in a ... Two main transferrin receptors found in humans denoted as transferrin receptor 1 (TfR1) and transferrin receptor 2 (TfR2). ... Beta-2 transferrin Transferrin receptor Total iron-binding capacity Transferrin saturation Ferritin Optiferrin recombinant ...
Increased levels of lactoferrin and transferrin inhibit bacterial growth by binding iron, an essential bacterial nutrient. The ... The binding of bacterial molecules to receptors on the surface of a macrophage triggers it to engulf and destroy the bacteria ... As with animals, plants attacked by insects or other pathogens use a set of complex metabolic responses that lead to the ... Gómez-Gómez L, Boller T (June 2000). "FLS2: an LRR receptor-like kinase involved in the perception of the bacterial elicitor ...
... receptors, antigen, b-cell MeSH D12.776.124.486.485.950.500 - antigens, cd79 MeSH D12.776.124.790.106.050 - alpha 1- ... antigen-antibody complex MeSH D12.776.124.486.485.114.301 - antitoxins MeSH D12.776.124.486.485.114.301.138 - antivenins MeSH ... transferrin MeSH D12.776.124.790.651.114.071 - antibodies, anti-idiotypic MeSH D12.776.124.790.651.114.107 - antibodies, ... bacterial MeSH D12.776.124.486.485.114.107.288 - antistreptolysin MeSH D12.776.124.486.485.114.125 - antibodies, bispecific ...
There is very high selectivity for transferrin receptors because they are over-expressed in cancer cells. If cells have high ... Bacterial death rates in these bags were compared with rates in unexposed control bags of the same organism. The bacterial " ... A residue of the AgBP is identified in the neighborhood of the antigen in their complex. This residue is changed into a ... by Quartz crystal microbalances with nanoparticles and transferrin that would potentially attach to transferrin receptors on ...
... forms a reddish complex with iron; its affinity for iron is 300 times higher than that of transferrin. The affinity ... The lactoferrin receptor plays an important role in the internalization of lactoferrin; it also facilitates absorption of iron ... Lactoferrin's primary role is to sequester free iron, and in doing so remove essential substrate required for bacterial growth ... Exons of the lactoferrin gene in oxen have a similar size to the exons of other genes of the transferrin family, whereas the ...
Gallium (III) (Ga3+) binds to transferrin, leukocyte lactoferrin, bacterial siderophores, inflammatory proteins, and cell- ... Somatostatin receptors are overexpressed in many NETs, so that the 68Ga DOTA conjugated peptide is preferentially taken up in ... The gallium-67 is then complexed with citric acid to form gallium citrate. The half-life of gallium-67 is 78 hours. It decays ... and for this reason can be used in leukopenic patients with bacterial infection (here it attaches directly to bacterial ...
The iron(III) complex is then reduced to iron(II) and the iron is transferred to nicotianamine, which although very similar to ... Transferrin is present in the serum at approximately 30 μM, and contains two iron-binding sites, each with an extremely high ... With bacterial vascular diseases, the infection is spread within the plants through the xylem. Once within the plant, the ... Siderophores are then recognized by cell specific receptors on the outer membrane of the cell. In fungi and other eukaryotes, ...
The complex phenotypes of several disorders are suspected to be caused by the involvement of moonlighting proteins. The protein ... Other proteins like bacterial spore coat, a slime mold cyst protein, and epidermis differentiation-specific protein, contain ... Moreover, in case of its iron import activities it can traffic into cells holo-transferrin as well as the related molecule ... Many proteins that moonlight are enzymes; others are receptors, ion channels or chaperones. The most common primary function of ...
Sex determination of common laboratory strains was shown to be a complex genetic trait, rather than to follow a simple ZW or XY ... In a glucocorticoid receptor-defective mutant with reduced exploratory behavior, fluoxetine rescued the normal exploratory ... D. rerio has three transferrins, all of which cluster closely with other vertebrates. When close relatives mate, progeny may ... Zebrafish models for a wide range of bacterial, viral and parasitic pathogens have already been established; for example, the ...
... is an integral bacterial outer membrane porin protein that belongs to outer membrane receptor family and provides the ... Both steps occur independently of the TonB-ExbB-ExbD complex and the proton motive force it provides. In the periplasm, FeEnt ... This can also be seen with pathogenic bacteria inside its host, where iron is bound tightly by haemoglobin, transferrin, ... The ferric enterobactin receptor FepA recognises the catecholate part of ferric enterobactin (FeEnt), and transports it across ...
5-trisphosphate receptor to regulate intracellular Ca2+ signaling; Oct-1 to form the coactivator complex OCA-S, which is ... "The macrophage cell surface glyceraldehyde-3-phosphate dehydrogenase is a novel transferrin receptor". The Journal of ... Bacterial GAPDH from Mycoplasma and Streptococcus and fungal GAPDH from Paracoccidioides brasiliensis are known to bind with ... "Characterization of glyceraldehyde-3-phosphate dehydrogenase as a novel transferrin receptor". The International Journal of ...
... also acts as a transferrin receptor. Transferrin-bound ferric iron is recognized by these transferrin receptors, triggering a ... Iron in such complexes can cause damage as described above. To prevent that kind of damage, all life forms that use iron bind ... Although this mechanism is an elegant response to short-term bacterial infection, it can cause problems when it goes on so long ... "Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary ...
Transferrin, on the other hand, has a pI of 5.9, so it cannot be easily separated by this method. A difference in pI of at ... Every intact antibody can bind to cell receptors or other proteins with its Fc region. MAbs approved by the FDA for cancer ... There may also be bacterial contamination and, as a result, endotoxins that are secreted by the bacteria. Depending on the ... Monoclonal antibodies are more expensive to manufacture than small molecules due to the complex processes involved and the ...
List of bacterial vaginosis microbiota Naito M, Hirakawa H, Yamashita A, Ohara N, Shoji M, Yukitake H, et al. (August 2008). " ... P. gingivalis can also degrade transferrin within host cells which provides the organism with an abundant iron source needed to ... January 2011). "The C5a receptor impairs IL-12-dependent clearance of Porphyromonas gingivalis and is required for induction of ... be associated with modulating β2 integrin adhesive activity for uptake by monocytes using the CD14/TLR2/PI3K signaling complex ...
... receptor, erbb-2 MeSH D12.776.624.664.700.790 - receptor, erbb-3 MeSH D12.776.624.664.700.800 - receptor, macrophage colony- ... electron transport complex iii MeSH D12.776.556.579.374.375.977 - nitrate reductase (nad(p)h) MeSH D12.776.556.579.374.375.988 ... transferrin MeSH D12.776.377.715.548.114 - antibodies MeSH D12.776.377.715.548.114.071 - antibodies, anti-idiotypic MeSH ... D12.776.377.715.548.114.107 - antibodies, archaeal MeSH D12.776.377.715.548.114.125 - antibodies, bacterial MeSH D12.776. ...
... the canine transferrin receptor. CPV2 has a high rate of evolution, possibly due to a rate of nucleotide substitution that is ... The fluids are typically a mix of a sterile, balanced electrolyte solution, with an appropriate amount of B-complex vitamins, ... Bacterial myocarditis has also been reported secondarily to sepsis. Dogs with CPV are at risk of intussusception, a condition ... and the success of new strains seems to depend on extending the range of hosts affected and improved binding to its receptor, ...
Complexes of zinc are mostly 4- or 6- coordinate, although 5-coordinate complexes are known. Zinc(I) compounds are very rare. ... In blood plasma, zinc is bound to and transported by albumin (60%, low-affinity) and transferrin (10%). Because transferrin ... The U.S. Food and Drug Administration (FDA) states that zinc damages nerve receptors in the nose, causing anosmia. Reports of ... One reported case of chronic ingestion of 425 pennies (over 1 kg of zinc) resulted in death due to gastrointestinal bacterial ...
... iron is stored in a protein complex as ferritin or the related complex hemosiderin. Apoferritin binds to free ferrous iron and ... H and M subunits of eukaryotic ferritin and all subunits of bacterial and archaeal ferritin are H-type and have ferroxidase ... Mizuno S, Mihara T, Miyaoka T, Inagaki T, Horiguchi J (March 2005). "CSF iron, ferritin and transferrin levels in restless legs ... Experimental COVID-19 vaccines have been produced that display the spike protein's receptor binding domain on the surface of ...
In blood plasma, zinc is bound to and transported by albumin (60%, low-affinity) and transferrin (10%). Because transferrin ... including complex I, complex III, and α-ketoglutarate dehydrogenase), the dysregulation of calcium homeostasis, glutamatergic ... ISBN 978-1-4288-1893-4. Hershfinkel, M; Silverman WF; Sekler I (2007). "The Zinc Sensing Receptor, a Link Between Zinc and Cell ... "The Role of Copper and Zinc Toxicity in Innate Immune Defense against Bacterial Pathogens". The Journal of Biological Chemistry ...
... including both soluble receptors and cell surface receptors (PGRP-LE and LC, respectively). Imd signalling culminates in the ... Disruption of the complex by mutations in either the PDZ domains or the target proteins reduces the efficiency of signaling. ... There are three transferrin orthologs, all of which are dramatically divergent from those known in chordate models. A March ... The transposable P elements, also known as transposons, are segments of bacterial DNA that are transferred into the fly genome ...
Receptor mediated Graves' disease Myasthenia gravis Type 3 hypersensitivity / Immune complex Foreign Henoch-Schönlein purpura ... C-reactive protein Ceruloplasmin C3 Ferritin Fibrin Haptoglobin Hemopexin Orosomucoid Negative Serum albumin Transferrin ... Post-streptococcal glomerulonephritis Serum sickness Arthus reaction Autoimmune Systemic lupus erythematosus Subacute bacterial ... Anaphylatoxin receptors C3a receptor C5a receptor (CD88) C5AR2 Fc receptor Fc-gamma receptors (FcγR) FcγRI (CD64) FcγRIIA ( ...
Staley, T. E.; Bush, L. J. (January 1985). "Receptor Mechanisms of the Neonatal Intestine and Their Relationship to ... The iron-binding glycoproteins lactoferrin and transferrin in bovine colostrum assist in attacking pathogens by impacting their ... "due to tremendous bacterial loads". Salmonella was also detected in 15% of unpasteurised samples. Pasteurisation reduces the ... with irregular oral intake of complex milk nutrients through the gastrointestinal tract. This transition puts high demands on ...
Spontaneous bacterial peritonitis can develop where there is ascites present. This is a frequent development in children but ... Anaemia (iron resistant microcytic hypochromic type) may be present due to transferrin loss. Dyspnea may be present due to ... "Podocyte protease activated receptor 1 stimulation in mice produces focal segmental glomerulosclerosis mirroring human disease ... "Mutations in multiple components of the nuclear pore complex cause nephrotic syndrome". Journal of Clinical Investigation. 128 ...
... estrogen receptor - estrogen receptor negative - estrogen receptor positive - estrogen receptor test - estrogen replacement ... bacterial toxin - barium enema - barium solution - barium swallow - Barrett's esophagus - basal cell - basal cell carcinoma - ... transferrin-CRM107 - transitional cell - transitional cell carcinoma - transperineal biopsy - transrectal biopsy - transrectal ... boronophenylalanine-fructose complex - bortezomib - Bowen's disease - BPH - brachial plexopathy - brachial plexus - ...
Streckfus C, Bigler L, Tucci M, Thigpen JT (2000). "A preliminary study of CA15-3, c-erbB-2, epidermal growth factor receptor, ... In 2010 Jou, et al., found that patients diagnosed with oral squamous cell carcinoma had elevated levels transferrin in saliva ... Matsubara K, Irie T, Uekama K (February 1997). "Spectroscopic characterization of the inclusion complex of a luteinizing ... either by spitting or interrupting the bioconversion of dietary nitrate to nitrite in the mouth with anti-bacterial mouthwash, ...
... bacterial transferrin receptor complex MeSH D12.776.157.905.500.249.500 - transferrin-binding protein a MeSH D12.776.157.905. ... tnf receptor-associated factor 1 MeSH D12.776.157.057.500.750 - tnf receptor-associated factor 2 MeSH D12.776.157.057.500.875 ... tnf receptor-associated factor 3 MeSH D12.776.157.057.500.937 - tnf receptor-associated factor 5 MeSH D12.776.157.057.500.968 ... electron transport complex i MeSH D12.776.157.530.450.250.875.468 - electron transport complex iii MeSH D12.776.157.530.450.250 ...
Bacterial Transferrin Receptor Complex Entry term(s). Transferrin Binding Protein Complex, Bacterial Transferrin-Binding ... Transferrin Binding Protein Complex, Bacterial. Transferrin-Binding Protein Complex, Bacterial. Tree number(s):. D12.776. ... Bacterial Transferrin Receptor Complex - Preferred Concept UI. M0404226. Scope note. A complex of proteins that forms a ... A complex of proteins that forms a receptor for TRANSFERRIN in BACTERIA. Many pathogenic bacteria utilize the transferrin- ...
Bacterial Secretion Systems G6.99.112.104 D5.500.890.500 G6.590.110.104 Bacterial Transferrin Receptor Complex D12.776.97.141 ... Receptor, ErbB-2 D23.101.840.642 D23.101.140.642 Receptor, ErbB-3 D23.101.840.721 D23.101.140.721 Receptor, ErbB-4 D23.101. ... Receptor, Adenosine A1 D12.776.543.750.810.700.100 Receptor, Adenosine A2A D12.776.543.750.810.700.200.100 Receptor, Adenosine ... Receptor, Notch2 D12.776.930.670.750 D12.776.930.770.750 Receptor, PAR-1 D12.776.543.750.705.675.892.790 Receptor, Serotonin, 5 ...
Bacterial Secretion Systems G6.99.112.104 D5.500.890.500 G6.590.110.104 Bacterial Transferrin Receptor Complex D12.776.97.141 ... Receptor, ErbB-2 D23.101.840.642 D23.101.140.642 Receptor, ErbB-3 D23.101.840.721 D23.101.140.721 Receptor, ErbB-4 D23.101. ... Receptor, Adenosine A1 D12.776.543.750.810.700.100 Receptor, Adenosine A2A D12.776.543.750.810.700.200.100 Receptor, Adenosine ... Receptor, Notch2 D12.776.930.670.750 D12.776.930.770.750 Receptor, PAR-1 D12.776.543.750.705.675.892.790 Receptor, Serotonin, 5 ...
Bacterial Secretion Systems G6.99.112.104 D5.500.890.500 G6.590.110.104 Bacterial Transferrin Receptor Complex D12.776.97.141 ... Receptor, ErbB-2 D23.101.840.642 D23.101.140.642 Receptor, ErbB-3 D23.101.840.721 D23.101.140.721 Receptor, ErbB-4 D23.101. ... Receptor, Adenosine A1 D12.776.543.750.810.700.100 Receptor, Adenosine A2A D12.776.543.750.810.700.200.100 Receptor, Adenosine ... Receptor, Notch2 D12.776.930.670.750 D12.776.930.770.750 Receptor, PAR-1 D12.776.543.750.705.675.892.790 Receptor, Serotonin, 5 ...
Bacterial Processes G6.99.112 G6.590.110 Bacterial Shedding G7.700.85 G7.75 Bacterial Transferrin Receptor Complex D12.776. ... Receptors, Transferrin D12.776.543.750.800 Receptors, Tumor Necrosis Factor, Member 14 D12.776.543.750.925.850 D12.776.543.750. ... Receptor Aggregation G4.299.780 G4.774 Receptor Cross-Talk G4.299.785 G4.794 Receptor Protein-Tyrosine Kinases D12.776.543.750. ... 60 D12.776.543.750.630 Receptor Tyrosine Kinase-like Orphan Receptors D12.776.543.750.60.233 D12.776.543.750.630.233 Receptor, ...
Bacterial Processes G6.99.112 G6.590.110 Bacterial Shedding G7.700.85 G7.75 Bacterial Transferrin Receptor Complex D12.776. ... Receptors, Transferrin D12.776.543.750.800 Receptors, Tumor Necrosis Factor, Member 14 D12.776.543.750.925.850 D12.776.543.750. ... Receptor Aggregation G4.299.780 G4.774 Receptor Cross-Talk G4.299.785 G4.794 Receptor Protein-Tyrosine Kinases D12.776.543.750. ... 60 D12.776.543.750.630 Receptor Tyrosine Kinase-like Orphan Receptors D12.776.543.750.60.233 D12.776.543.750.630.233 Receptor, ...
Bacterial Transferrin Receptor Complex [D12.776.097.120.300] * Fimbriae Proteins [D12.776.097.120.425] ... Bacterial Proteins [D12.776.097] * Antigens, Bacterial [D12.776.097.025] * Adhesins, Bacterial [D12.776.097.025.050] * Adhesins ... Bacterial Proteins [D12.776.097] * Bacterial Outer Membrane Proteins [D12.776.097.120] * Adhesins, Bacterial [D12.776.097.120. ... Adhesin, Bacterial Adhesins, Fimbrial Bacterial Adhesin Bacterial Adhesins Fimbrial Adhesins Registry Number. 0. Previous ...
Maiden MC, van Rensburg MJ, Bray JE, Earle SG, Ford SA, Jolley KA, MLST revisited: the gene-by-gene approach to bacterial ... The hemoglobin receptor is detected more frequently among isolates involved with disease than among those involved with ... We tested the virulence of these isolates in a relevant animal model, transgenic mice expressing the human transferrin (13). ... lacked the hpuA and hpuB genes that mediate heme-iron acquisition from hemoglobin and hemoglobin-haptoglobin complexes. However ...
Pathogenic bacteria exploit transferrin receptor transcytosis to penetrate the blood-brain barrier. ... complex on BCVs to authenticate the precise recognition and selection of TfR vesicles to fuse with and facilitate bacterial ... Toll-like receptor signals emanating from bacteria-containing vesicles (BCVs) trigger K33-linked polyubiquitination at Lys168 ... Meningitis is among the most serious diseases, but the mechanisms by which major meningitis-causing bacterial pathogens cross ...
Transferrin and the blood brain barrier. Transferrin, an iron binding protein that facilitates iron uptake in cells, is an ... After interacting with CARD-CARD, NOD2 may bind/activate RIP2/RICK and this active NOD2:RIP2 complex then stimulates MAPK (JNK ... NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation. Nat. Med. Dec 6 ... Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) is an intracellular pattern recognition receptor (PRR) ...
Bacterial Outer Membrane Proteins. *Bacterial Proton-Translocating ATPases. *Bacterial Transferrin Receptor Complex ...
The receptor-holotoxin complex is endocytosed.. * The complex moves to Golgi apparatus and then to the endoplasmic reticulum. ... Bacterial shedding usually ceases within 4 weeks of the onset of illness; rarely, it can persist for months. Appropriate ... transferrin and lactoferrin). Many bacteria can secrete iron chelating compounds, or siderophores, which chelate iron from the ... Treatment of bacterial enteritis. Pediatr Infect Dis J. 1998 May. 17(5):420-1. [QxMD MEDLINE Link]. ...
M catarrhalis also expresses specific proteins for iron uptake that act as receptors for transferrin and lactoferrin. ... Bacterial infection in chronic obstructive pulmonary disease in 2000: a state-of-the-art review. Clin Microbiol Rev. 2001 Apr. ... produce a protein that confers resistance to complement by interfering with the formation of the membrane attack complex. ... Efficacy and safety of moxifloxacin for community-acquired bacterial pneumonia based on pharmacokinetic analysis. J Infect ...
Catecholamine stress hormones are in a position to bind transferrin and lactoferrin, to kind direct complexes with ferric iron ... This capability of stress hormones to mediate bacterial iron acquisition from transferrin and lactoferrin has been proposed to ... Endotoxin recognition molecules MD-2 and toll-like receptor 4 also may be thought-about as potential targets for therapeutic ... Gonococcal transferrin-binding protein 2 facilitates however just isnt essential for transferrin utilization. The iron-binding ...
Residues shown to affect transferrin binding are indicated and were used when modeling the complex with transferrin. b. SAXS ... These receptors are used specifically by Neisseria to pirate iron from the abundant human iron binding protein, transferrin, ... Bacterial amyloids contribute to biofilm formation and stability. Tooth decay is the most common infectious disease in the ... Figure 2. Models for the Neisserial TbpB and human transferrin complex and for the fully assembled iron import complex from ...
Intracellular Delivery of a Planar DNA Origami Structure by the Transferrin-Receptor Internalization Pathway. Small, 12(19), ... Structure and Function of the Bacterial Protein Toxin Phenomycin. Structure, 28(5), 528-539.e9. https://doi.org/10.1016/j.str. ... a quantum leap for self-assembly of complex structures. Chemical Society Reviews, 40. https://doi.org/10.1039/c1cs15057j ... transferrin and other metal-binding proteins. Nature Chemistry, 6(9), 804-809. https://doi.org/10.1038/nchem.2003 ...
The obesogenic diet shapes the microbiome prior to the development of obesity, leading to altered bacterial metabolite ... Hepatocyte nuclear factor 4alpha controls iron metabolism and regulates Transferrin receptor 2 in mouse liver. J Biol Chem. ... Multidomain integration in the structure of the HNF-4alpha nuclear receptor complex. Nature. 2013;495:394-8. ... a Study design of bacterial transplantation. b Weights of germ-free mice on either HFD or LFD that have been transplanted with ...
... iron-trans- ferrin complexes, and waste metabolites as well as potential toxins produced dur- ing substrate metabolism. As ... Inactivation and Detoxification of Xenobiotic receptor-related endocytic processes can be Compounds and Metabolites used as ... such as NH4 produced from bacter- ial metabolism in the gut). In addition to the blood supply from the portal vein, the liver ... targets to probe specific receptor- Xenobiotics are compounds that have no nutrient value (cannot be used by the body mediated ...
OBJECTIVES: The clinical use of soluble transferrin receptor (sTfR) as an iron status indicator is hindered by a lack of assay ... Both simple and complex inequality metrics, with the maternal mortality ratios (MMRs), were then calculated using the ... We used a dataset of metabolic characteristics from a de-identified set of known bacterial strains that the Special ... RESULTS: Bacterial (cases, 93%; controls, 72%), viral (63%, 56%), and protozoal (50%, 38%) pathogens were commonly detected ( ...
Golgi complex( Brugger et al. Darby MPO)-mediated resource( MDCK) pre-mRNAs are that there are steps from the cell-death, ... tight TCF7 results among the several centrosomes been in ligand PER give the T of gradient complex, on both the signaling and ... reticulum is alone receptor, also. There conjugates no renewable element, but there processes a interaction. If this is urinary ... These gene roles reviewed to cyclin-dependent hypoxanthine from the transferrin. The download manual of structural kinesiology ...
This effect was due to the partial restoration of the expression in the liver of the genes encoding the FGF21 FGFR1 receptor ... 44 obese subjects supplemented with curcumin complexed with. phosphatidylserine in phytosome form. ↑BW loss ↑Enhance body fat ... Pichia anomalia and Bacillus megateriumdcmb, are all biologically relevant bacterial strains capable of degrading curcumin [23 ... The human body also has proteins (transferrin, ferritin, caeruloplasmin and lactoferrin), with antioxidant properties and ...
This is followed by viraemia (Sykes, 2014). Via the transferrin receptor, CPV-2 enters cells with a high division rate (Parker ... Feline respiratory tract infection - how to choose between PCR and bacterial culture. 30. May 2023. ... These include myocarditis, hepatitis, chronic immune complex disease and meningoencephalitis (Berns and Parrish, 2007). Since ... Canine and feline parvoviruses can use human or feline transferrin receptors to bind, enter, and infect cells. J Virol. 2001; ...
Have shown that iron oxide labeling of HeLa and MSCs resulted in a transient decrease in transferrin receptor-1 (TfR-1) mRNA ... Commonly, one mRNA is produced from a complex transcription unit in some cell types, and an alter- native mRNA is made in other ... Fkrex group of plasma membrane-bound receptors called the TollIL-1R family plays a key role in leukocyte responses to bacterial ... The insulin receptor is a disulfide-bonded dimer of α β pairs even when insulin is not bound. [2] O. 320 C. American Philosophi ...
Sickness behavior is a behavioral complex induced by infections and immune trauma and mediated by pro-inflammatory cytokines. ... soluble interleukin-2 and transferrin receptor in major depression. J Affect Disord. 1995, 34: 301-309. 10.1016/0165-0327(95) ... which otherwise would activate bacterial production [34]. Iron is one of the nutrients employed by bacteria for bacterial ... Such a prolonged sickness behavior complex is likely to be dysfunctional [26] as is the case in more chronic infections and ( ...
Transferrin receptor 2 is crucial for iron sensing in human hepatocytes. American Journal of Physiology: Gastrointestinal and ... Identification of an iron-hepcidin complex. Farnaud, S., Rapisarda, C., Bui, T.T.T., Drake, A.F., Cammack, R. and Evans, R.W. ... Bacterial lipopolysaccharide directly stimulates cortisol secretion in human adrenal cells. Endocrine Research. 28 (4), pp. 357 ... Transferrin receptor 2 is crucial for iron sensing in human hepatocytes. Rapisarda, C., Puppi, J., Hughes, R.D., Dhawan, A., ...
The ebook of receptors your Abstract indicated for at least 10 links, or for also its dietary space if it deteriorates shorter ... To sign a full failure of this growth, we are caused a complex and Cardiac ventricular product( Drug of implantable temperature ... Second Messenger Systems: guidelines in which an 31-AUG-2008 Anaesthesia triggers displayed in therapy to an bacterial septal ... 2002 March-April; bad): 110-6. bacteria decreasing wide transferrin function of epidemic disease. ebook Birational Geometry of ...
urinary tract infections Bacterial Urinary Tract Infections Bacterial urinary tract infections (UTIs) can involve the urethra, ... B-complex vitamins at twice the recommended daily allowance are given parenterally for the first 3 days, usually with vitamin A ... Measurement of serum albumin, total lymphocyte count, CD4+ T lymphocytes, transferrin, and response to skin antigens may help ... C-reactive protein or soluble interleukin-2 receptor should be measured when the cause of undernutrition is unclear; these ...
  • A complex of proteins that forms a receptor for TRANSFERRIN in BACTERIA. (bvsalud.org)
  • M catarrhalis also expresses specific proteins for iron uptake that act as receptors for transferrin and lactoferrin. (medscape.com)
  • In eukaryotic cells, chromatin comprises a complex consisting of DNA, RNA, and proteins where covalent modifications correlate with regulation of gene expression [ 1 ]. (biomedcentral.com)
  • The human leukocyte antigen ( HLA ) is a gene complex that encodes the major histocompatibility complex ( MHC ) proteins . (amboss.com)
  • The assembly of protein complexes and compositional lipid patterning act together to endow cells with the plasticity required to maintain compositional heterogeneity with respect to individual proteins. (biomedcentral.com)
  • The PM provides an environment in which macromolecules interact efficiently, including the clustering of proteins in oligomeric complexes via protein-protein or protein-lipid interactions, the docking and anchoring of protein complexes for regulatory reactions and other precisely orchestrated processes [ 1 ]. (biomedcentral.com)
  • Many pathogenic bacteria utilize the transferrin-binding complex to acquire their supply of iron from serum. (bvsalud.org)
  • Cell-surface components or appendages of bacteria that facilitate adhesion (BACTERIAL ADHESION) to other cells or to inanimate surfaces. (wakehealth.edu)
  • Most fimbriae (FIMBRIAE, BACTERIAL) of gram-negative bacteria function as adhesins, but in many cases it is a minor subunit protein at the tip of the fimbriae that is the actual adhesin. (wakehealth.edu)
  • It is best in case of planktonic micro organism and less efficient in the eradicating of encapsulated bacteria and bacterial L-varieties. (wagergun.com)
  • It induces both local effects in the gut, as well as alterations in distant organs through stimuli generated by bacteria, structural bacterial components, and microbial metabolites [ 7 ]. (biomedcentral.com)
  • Catecholamine stress hormones are in a position to bind transferrin and lactoferrin, to kind direct complexes with ferric iron, and to scale back ferric to ferrous iron with subsequent liberation from transferrin (Sandrini et al. (wagergun.com)
  • This capability of stress hormones to mediate bacterial iron acquisition from transferrin and lactoferrin has been proposed to perform in biofilm formation in intravenous lines by the Gram-optimistic bacterium S. (wagergun.com)
  • It operates based on inherited cellular receptors that respond to broad pathogen -related patterns and common threat signals. (amboss.com)
  • ELAC1 has been in the use and may as define as an RNase Z. In pyrophosphates subfamilies are transcribed from coupling tubules in the function by a two receptor chromatin that appears ultraviolet from protein threatening( reviewed in Popow et al. (evakoch.com)
  • Whole-genome sequencing of Neisseria meningitidis serogroup X isolates from sub-Saharan Africa and Europe showed that serogroup X emergence in sub-Saharan Africa resulted from expansion of particular variants within clonal complex 181. (cdc.gov)
  • Cyclic epidemics spanned the meningitis belt and were caused mainly by isolates of N. meningitidis serogroup A that belonged to several genetic lineages called clonal complexes (CCs). (cdc.gov)
  • We adapted a broth microdilution method for determining chlorhexidine MICs, poured panels, established quality control ranges, and tested Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, and Enterobacter cloacae complex isolates collected at three U.S. sites. (cdc.gov)
  • Chlorhexidine MICs were determined for 535 isolates including 129 S. aureus, 156 E. coli, 142 K. pneumoniae, and 108 E. cloacae complex isolates. (cdc.gov)
  • Adhesins, Bacterial" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)
  • reticulum is alone receptor, also. (erik-mill.de)
  • amino-terminal download supports to follow triple and also active fractions appearing on the complex reticulum. (evakoch.com)
  • 2010). Free iron can then be used for bacterial development through other specific iron uptake techniques. (wagergun.com)
  • Some strains produce a protein that confers resistance to complement by interfering with the formation of the membrane attack complex. (medscape.com)
  • Gonococcal transferrin-binding protein 2 facilitates however just isn't essential for transferrin utilization. (wagergun.com)
  • reaction Because of obstructive hypotheses by derivative complexes and the protein of the part, it alters Randomized also other to splint about the Acids improved for PATIENT heart exercise. (augenta.net)
  • Cytopathic results are changes in host cells due toA) viral infections.B) protozoan infections.C) fungal infections.D) bacterial infections.E) helminthic infections. (wagergun.com)
  • Sickness behavior is a behavioral complex induced by infections and immune trauma and mediated by pro-inflammatory cytokines. (biomedcentral.com)
  • Sickness behavior is a behavioral complex that is typically induced by acute infections and tissue injury in many mammalian species. (biomedcentral.com)
  • Via the transferrin receptor, CPV-2 enters cells with a high division rate (Parker et al. (laboklin.com)
  • Sertoli cells have receptors for FSH. (medicosplexus.com)
  • In HCMV-infected cells, particular subsets of CDK-cyclin complexes are downregulated/suppressed (CDK4-cyclin D, CDK6-cyclin D, CDK2-cyclin A) or upregulated/turned on (CDK1-cyclin B, CDK2-cyclin E), leading to an early on S stage arrest termed pseudomitosis [11] eventually. (niepokorny.org)
  • With the Isotonix Daily Essentials Packets, you can be sure that you're giving your body the essential vitamins, minerals and nutrients it needs, thanks to four essential supplements - Isotonix OPC-3, Isotonix Multivitamin, Isotonix Activated B-Complex and Isotonix Calcium Plus - in one, convenient serving to promote long-term health and optimal nutrition. (etnad3.com)
  • To provide the energy you need to function throughout the day, each packet includes Isotonix Activated B-Complex, which delivers metabolically active forms of several vitamins and minerals. (etnad3.com)
  • other specificity is tiny gene activity and distribution browser through the kinase of the R-RasGAP complex ileal to suitable or through the functionality of RhoA. (evakoch.com)
  • Activated forms are important because traditional forms of vitamins B6, B12 and folic acid found in most other B-complex products must undergo chemical changes in order to be utilized by the body. (etnad3.com)
  • The obesogenic diet shapes the microbiome prior to the development of obesity, leading to altered bacterial metabolite production which predisposes the host to obesity. (biomedcentral.com)
  • This graph shows the total number of publications written about "Adhesins, Bacterial" by people in this website by year, and whether "Adhesins, Bacterial" was a major or minor topic of these publications. (wakehealth.edu)
  • receptors and dileucine-: TLR1 photosynthesis cell in New Zealand 1945 -1960: family understood in bovine RELB of the Associations for the peptidyl of Master of Arts. (evakoch.com)
  • Most conserved parameter in human and bacterial Cytochrome C who has 50% identity of amino acid sequence with that of human is Tertiary structure. (medicosplexus.com)
  • Two outer membrane proteins, TbpA (receptor and transporter) and TbpB (a lipoprotein co-receptor) work in concert to bind and extract iron specifically from human transferrin (hTF), making them primary targets for both drug and vaccine development. (nih.gov)
  • Insertion of proteins and lipopolysaccharide into the bacterial outer membrane. (nih.gov)
  • Protein import and export across the bacterial outer membrane. (nih.gov)
  • Pathogenic Neisseria are responsible for causing gonorrhoea, meningococcal septicaemia, and bacterial meningitis. (nih.gov)
  • Whole-genome sequencing of Neisseria meningitidis serogroup X isolates from sub-Saharan Africa and Europe showed that serogroup X emergence in sub-Saharan Africa resulted from expansion of particular variants within clonal complex 181. (cdc.gov)
  • To aid these efforts, we determined the crystal structures of (1) TbpA in complex with hTF and (2) TbpB alone, identifying key residues and extracellular loops important for therapeutic development. (nih.gov)
  • Nearly 75% of host iron is found in erythrocyte hemoglobin, with the remainder either stored intracellularly as ferritin or bound tightly to extracellular proteins such as transferrin. (medscape.com)
  • A complex containing protein, located on a cell membrane, capable of being stimulated by drugs in the extracellular fluid, and translating that stimulation into an intracellular response. (unboundmedicine.com)
  • Small extracellular vesicles containing transferrin receptors were first reported in 1983 by Johnstone and colleagues while culturing reticulocytes [ 10 ]. (biomedcentral.com)
  • After affinity maturation, several engineered lipocalin variants were identified that bind murine TfR in a non-competitive manner with the natural ligand (transferrin â Fe3+ ), among those an Anticalin - dubbed FerryCalin - exhibiting a dissociation constant (KD ) of 3.8â nM. (bvsalud.org)
  • 4. Ligand substitution of receptor targeted DNA complexes affects gene transfer into hepatoma cells. (nih.gov)
  • The selection is a valuable reference for readers interested in membrane proteins, receptor ligand interactions, and monoclonal antibodies. (elsevier.com)
  • The transferrin receptor (TfR) mediates transcytosis across the blood-brain barrier (BBB), which offers a promising approach for the non-invasive delivery of therapeutics into the brain parenchyma. (bvsalud.org)
  • The cell-to-cell signaling and regulating effects of chemokines, e.g., on inflammation or hematopoiesis, are mediated through chemokine receptors, which can be blocked with specific antagonist drugs. (unboundmedicine.com)
  • CCR5 and CXCR4 are chemokine receptors that are also receptors for HIV. (unboundmedicine.com)
  • KEGG pathway analysis revealed that genes associated with TNF signaling, NF-KB signaling, and Th17 signaling were up-regulated, and genes associated with chemokine signaling and B cell receptor signaling were down regulated. (biomedcentral.com)
  • The transferrin receptor participates in stealing iron from host transferrin, a glycoprotein that binds iron. (nih.gov)
  • We recently discovered an important key to how nascent iron-sulfur clusters are targeted to recipient proteins by the chaperone-cochaperone complex composed of HSPA9, HSC20, the scaffold ISCU bearing a newly formed iron-sulfur cluster, and recipient proteins, which contain LYR motifs to which HSC20 binds. (nih.gov)
  • CD4 receptors on T4 lymphocytes are the sites to which HIV binds, producing infection. (unboundmedicine.com)
  • A molecule whose structure mimics a cellular receptor, and binds those agents (e.g., cytokines, drugs or hormones) that normally bind to the receptor. (unboundmedicine.com)
  • A receptor on phagocytes (neutrophils, monocytes, and macrophages) that binds Fc fragments of immunoglobulins G and E. (unboundmedicine.com)
  • In addition, we seek to understand the role of iron-sulfur cluster assembly in regulation of mitochondrial iron homeostasis, and to understand the pathogenesis of diseases such as Friedreich ataxia, ISCU myopathy, sideroblastic anemia, and numerous types of neonatal acidosis in which mitochondrial iron cluster biogenesis is impaired.We have identified mammalian homologues of over twenty proteins involved in bacterial and yeast iron-sulfur cluster biogenesis. (nih.gov)
  • This limitation occurs because most of the iron in human body is sequestered in hemoproteins (i.e., hemoglobin, myoglobin) or iron-chelating proteins involved in iron transport (transferrin and lactoferrin). (medscape.com)
  • Cyclic epidemics spanned the meningitis belt and were caused mainly by isolates of N. meningitidis serogroup A that belonged to several genetic lineages called clonal complexes (CCs). (cdc.gov)
  • Many of the session's six presenters either combine multiple methods or use traditional methods in new and unique ways to examine the heterogeneous, dynamic molecular complexes that lie at the heart of many biological phenomena. (nih.gov)
  • 17. Self-assembled ternary complexes of plasmid DNA, low molecular weight polyethylenimine and targeting peptide for nonviral gene delivery into neurons. (nih.gov)
  • Interaction Between Hyaluronic Acid and Its Receptors INTERACTION BETWEEN HYALURONIC ACID AND ITS RECEPTORS (CD44, RHAMM) REGULATES THE ACTIVITY OF INFLAMMATION AND CANCER Topic Editor: David Naor, Hebrew University of Jerusalem, Israel The biological outcome of Hyaluronan (also hyaluronic acid, abbreviated HA) interaction with its CD44 or RHAMM receptors recently attracted much attention within the scientific community owing to a Nature article by Tian X et al. (pdfhost.io)
  • The peroxisomal proliferating-activated receptors (PPARs) are lipid-sensing transcription factors that have a role in embryonic development, but are primarily known for modulating energy metabolism, lipid storage, and transport, as well as inflammation and wound healing. (westminster.ac.uk)
  • [ 6 ] Escherichia coli , Klebsiella pneumoniae, and Salmonella species secrete iron chelators, known as siderophores, to compete with transferrin for available iron. (medscape.com)
  • In vitro evidence suggests that increased iron availability promotes bacterial growth and virulence. (medscape.com)
  • Herein, we have discovered that biomolecular condensates of biologically active human serum transferrin (Tf) can effectively prevent surface-induced fibrillation and preserve the native-like conformation of phase-separated Tf over a period of 30 days. (bvsalud.org)
  • An EM 3D reconstruction of the TbpA-TbpB-hTF complex, along with our crystal structures and SAXS analysis, allows us to provide the first glimpse of what the iron import machinery may look at the cell surface during infection. (nih.gov)
  • NLCs were broadly studied as delivery systems for a variety of therapeutic and cosmetic applications for parenteral, topical, oral, ophthalmic, and pulmonary administration for management of central nervous system diseases, inflammatory diseases, skin conditions, bacterial and fungal infection, as well as the administration of local anesthetics [3] . (cd-bioparticles.net)
  • Receptors, primarily on white blood cells, that bind with epitopes on foreign antigens, stimulating an immune response. (unboundmedicine.com)
  • Any of at least six receptors that bind dopamine in the brain. (unboundmedicine.com)
  • Iron is transported as heme into the bacterial cell for use as a nutrient. (medscape.com)
  • The iron-regulatory hormone hepcidin is highly upregulated during malaria and controls the availability of iron, a critical nutrient for bacterial growth. (haematologica.org)
  • A biochemical and structural understanding of TOM complex interactions and implications for human health and disease. (nih.gov)
  • Afterwards, we surveyed the various biological functions of transferrin, such as Fe3+ binding, receptor binding, antibacterial activity, growth, differentiation, and coagulation, followed by the application of transferrin-modified NPs in the development of drug delivery systems for cancer therapy. (bvsalud.org)
  • We then overviewed the transferrin structure and its direct interaction with NPs to explore transferrin stability and its iron ion (Fe3+) release behavior. (bvsalud.org)
  • Deciphering this structure, Noinaj said, "represents a significant advancement in our knowledge of iron import by bacterial pathogens" and offers new data that will be useful for vaccine and drug development. (nih.gov)
  • In the present study, shotgun proteomic analyses of immunoprecipitated mouse brain Kv4.2 channel complexes unexpectedly identified the voltage-gated Na⁺ channel accessory subunit Navβ1. (nih.gov)
  • 3. A powerful cooperative interaction between a fusogenic peptide and lipofectamine for the enhancement of receptor-targeted, non-viral gene delivery via integrin receptors. (nih.gov)
  • Clathrin-mediated endocytosis, which depends on the AP2 complex, plays an essential role in many cellular and developmental processes in mammalian cells. (biologists.com)
  • Any of the markers on T lymphocytes and other white blood cells that, along with major histocompatibility complex (MHC) genes, is responsible for the recognition of antigens. (unboundmedicine.com)
  • Epitope analysis using the SPOT technique revealed a sequential epitope in a surface region of TfR remote from the transferrin-binding site. (bvsalud.org)
  • Due to the fast kon rate and short complex half-life, as evidenced by real-time surface plasmon resonance (SPR) measurements, FerryCalin, or one of its related mutants, shows characteristics as a potential vehicle for the brain delivery of biopharmaceuticals. (bvsalud.org)
  • 13. Receptor-mediated gene delivery using polyethylenimine (PEI) coupled with polypeptides targeting FGF receptors on cells surface. (nih.gov)
  • Any of the proteins on the surface of T lymphocytes that enhance the response of the T-cell receptor to foreign antigens and stimulate signals from the receptor to the cytoplasm. (unboundmedicine.com)
  • A receptor that produces a sensation such as touch, temperature, or pain that can be localized in or on the surface of the body. (unboundmedicine.com)
  • Cryo-EM structure of the bacterial Ton motor subcomplex ExbB-ExbD provides information on structure and stoichiometry. (nih.gov)
  • Structure of the NPr:EIN(Ntr) Complex: Mechanism for Specificity in Paralogous Phosphotransferase Systems. (nih.gov)
  • 15. Further studies on targeted DNA transfer to cells using a highly efficient delivery system of biotinylated transferrin and biotinylated polylysine complexed to streptavidin. (nih.gov)
  • The virus uses these receptors to gain entry into T cells, macrophages, and other CD4 + cells. (unboundmedicine.com)
  • In vitro, abrogation of cFLIP cleavage sensitizes cells to tumor necrosis factor(TNF)-induced necroptosis and apoptosis by favoring complex-II formation. (sfb1530.de)
  • We show that the adhesive, self-healing and antimicrobial hydrogel is suitable for the unique scratching and bacterial environment of AD skin. (nature.com)
  • A receptor located in the skin. (unboundmedicine.com)
  • Hurley also presented data from his own group and collaborators, including Gerhard Hummer (NIDDK), on the endosomal-sorting complex required for transport (ESCRT). (nih.gov)
  • A presynaptic receptor in the central nervous system that controls the release of histamine and other neurotransmitters, including acetylcholine, dopamine, and norepinephrine. (unboundmedicine.com)
  • Identification of Navβ1 in mouse brain Kv4.2 channel complexes. (nih.gov)
  • Structural insight into the role of the Ton complex in energy transduction. (nih.gov)