Bacterial Transferrin Receptor Complex
Transferrins
Receptors, Transferrin
Transferrin
Neisseria meningitidis
A species of gram-negative, aerobic BACTERIA. It is a commensal and pathogen only of humans, and can be carried asymptomatically in the NASOPHARYNX. When found in cerebrospinal fluid it is the causative agent of cerebrospinal meningitis (MENINGITIS, MENINGOCOCCAL). It is also found in venereal discharges and blood. There are at least 13 serogroups based on antigenic differences in the capsular polysaccharides; the ones causing most meningitis infections being A, B, C, Y, and W-135. Each serogroup can be further classified by serotype, serosubtype, and immunotype.
Meningitis, Meningococcal
A fulminant infection of the meninges and subarachnoid fluid by the bacterium NEISSERIA MENINGITIDIS, producing diffuse inflammation and peri-meningeal venous thromboses. Clinical manifestations include FEVER, nuchal rigidity, SEIZURES, severe HEADACHE, petechial rash, stupor, focal neurologic deficits, HYDROCEPHALUS, and COMA. The organism is usually transmitted via nasopharyngeal secretions and is a leading cause of meningitis in children and young adults. Organisms from Neisseria meningitidis serogroups A, B, C, Y, and W-135 have been reported to cause meningitis. (From Adams et al., Principles of Neurology, 6th ed, pp689-701; Curr Opin Pediatr 1998 Feb;10(1):13-8)
Neisseria meningitidis, Serogroup B
Neisseria meningitidis, Serogroup C
Neisseria meningitidis, Serogroup A
Construction and characterization of Moraxella catarrhalis mutants defective in expression of transferrin receptors. (1/4)
We have previously reported the construction of an isogenic mutant defective in expression of OmpB1, the TbpB homologue, in Moraxella catarrhalis 7169. In this report, we have extended these studies by constructing and characterizing two new isogenic mutants in this clinical isolate. One mutant is defective in expression of TbpA, and the other mutant is defective in expression of both TbpA and TbpB. These isogenic mutants were confirmed by using PCR analysis, sodium dodecyl sulfate-polyacrylamide gel electrophoresis, and sequencing. In vitro growth studies, comparing all three mutants, demonstrated that the tbpA mutant and the tbpAB mutant were severely limited in their ability to grow with human holotransferrin as the sole source of iron. In contrast, the ompB1 (tbpB) mutant was capable of utilizing iron from human transferrin, although not to the extent of the parental strain. While affinity chromatography with human holotransferrin showed that each Tbp was capable of binding independently to transferrin, solid-phase transferrin binding studies using whole cells demonstrated that the tbpA mutant exhibited binding characteristics similar to those seen with the wild-type bacteria. However, the ompB1 (tbpB) mutant exhibited a diminished capacity for binding transferrin, and no binding was detected with the double mutant. These data suggest that the M. catarrhalis TbpA is necessary for the acquisition of iron from transferrin. In contrast, TbpB is not essential but may serve as a facilitory protein that functions to optimize this process. Together these mutants are essential to provide a more thorough understanding of iron acquisition mechanisms utilized by M. catarrhalis. (+info)Staphylococcus aureus siderophore-mediated iron-acquisition system plays a dominant and essential role in the utilization of transferrin-bound iron. (2/4)
Staphylococcus aureus is known to be capable of utilizing transferrin-bound iron, via both siderophore- and transferrin-binding protein (named IsdA)-mediated iron-acquisition systems. This study was designed in order to determine which iron-acquisition system plays the essential or dominant role with respect to the acquisition of iron from human transferrin, in the growth of S. aureus. Holotransferrin (HT) and partially iron-saturated transferrin (PT), but not apotransferrin (AT), were found to stimulate the growth of S. aureus. S. aureus consumed most of the transferrin-bound iron during the exponential growth phase. Extracellular proteases were not, however, involved in the liberation of iron from transferrin. Transferrin-binding to the washed whole cells via IsdA was not observed during the culture. The expression of IsdA was observed only in the deferrated media with AT, but not in the media supplemented with PT or HT. In contrast, siderophores were definitely produced in the deferrated media with PT and HT, as well as in the media supplemented with AT. The siderophores proved to have the ability to remove iron directly from transferrin, but the washed whole cells expressing IsdA did not. In the bioassay, the growth of S. aureus on transferrin-bound iron was stimulated by the siderophores alone. These results demonstrate that the siderophore-mediated iron-acquisition system plays a dominant and essential role in the uptake of iron from transferrin, whereas the IsdA-mediated iron-acquisition system may play only an ancillary role in the uptake of iron from transferrin. (+info)FbpA--a bacterial transferrin with more to offer. (3/4)
(+info)Use of an isogenic mutant constructed in Moraxella catarrhalis To identify a protective epitope of outer membrane protein B1 defined by monoclonal antibody 11C6. (4/4)
Moraxella catarrhalis-induced otitis media continues to be a significant cause of infection in young children, prompting increased efforts at identifying effective vaccine antigens. We have previously demonstrated that M. catarrhalis expresses specific outer membrane proteins (OMPs) in response to iron limitation and that this organism can utilize transferrin and lactoferrin for in vitro growth. One of these proteins, which binds human transferrin, is OMP B1. As the human host presents a naturally iron-limited environment, proteins, like OMP B1, which are expressed in response to this nutritional stress are potential vaccine antigens. In this study, we have developed monoclonal antibody (MAb) 11C6, which reacts to a surface-exposed epitope of OMP B1 expressed by M. catarrhalis 7169. This antibody was used to clone ompB1, and sequence analysis suggested that OMP B1 is the M. catarrhalis homologue to the transferrin binding protein B described for pathogenic Neisseriaceae, Haemophilus influenzae, Actinobacillus pleuropneumoniae, and M. catarrhalis. Expression of recombinant OMP B1 on the surface of Escherichia coli confers transferrin binding activity, confirming that this protein is likely involved in iron acquisition. In addition, ompB1 was used to construct an isogenic mutant in M. catarrhalis 7169. This mutant, termed 7169b12, was used as the control in bactericidal assays designed to determine if OMP B1 elicits protective antibodies. In the presence of MAb 11C6 and human complement, wild-type 7169 demonstrated a 99% decline in viability, whereas the ompB1 isogenic mutant was resistant to this bactericidal activity. Further analysis with MAb 11C6 revealed the presence of this OMP B1 epitope on 31% of the clinical isolates tested. These data suggest that OMP B1 is a potential vaccine antigen against M. catarrhalis infections. (+info)The Bacterial Transferrin Receptor Complex refers to the iron-binding protein Transferrin, when bound to bacterial surface receptors, facilitating iron acquisition and contributing to microbial virulence and survival within host environments.
I'm not able to find a specific medical definition for the term "Bacterial Transferrin Receptor Complex" as it is not a widely recognized or established term in the field of medicine. However, I can provide some background information that might help you understand the possible meaning behind this term.
Transferrin receptors are proteins found on the surface of many types of cells, including human cells. They play an essential role in iron metabolism by binding to transferrin, a protein that carries iron through the bloodstream. This interaction allows cells to take up and utilize iron for various biological processes.
In some bacteria, similar receptors have been identified that can bind to transferrin or other host proteins to acquire essential nutrients like iron. These bacterial transferrin receptor-like structures might be involved in the pathogenesis of certain bacterial infections by helping the bacteria obtain necessary resources for growth and survival within the human body.
However, it is important to note that the term "Bacterial Transferrin Receptor Complex" may not refer to a specific, well-defined entity in medical research. If you are looking for information on a particular study or context related to this term, I would recommend consulting the original source or seeking further clarification from the author(s) of the source where you encountered this term.
Transferrins are glycoprotein transporter molecules that bind and transport iron ions in the blood to maintain iron homeostasis, protect against oxidative stress, and deliver iron to cells for essential biological functions. (26 words)
Transferrins are a type of protein found in the plasma component of blood that bind and transport iron ions (Fe3+) from digestion of food or recycling of red blood cells to the cells where they are needed for various metabolic processes, such as the production of hemoglobin. They play a crucial role in maintaining iron homeostasis in the body by preventing the accumulation of free iron, which can be toxic and contribute to the development of oxidative stress and diseases. Transferrins have a high affinity for iron and are capable of binding two ferric ions per molecule. The transferrin-iron complex is then recognized and internalized by specific transferrin receptors on the surface of cells, where the iron is released and utilized.
Transferrin receptors are membrane-bound proteins that facilitate the cellular uptake and iron release from transferrin, a glycoprotein responsible for transporting iron in the bloodstream, through receptor-mediated endocytosis.
Transferrin receptors are membrane-bound proteins found on the surface of many cell types, including red and white blood cells, as well as various tissues such as the liver, brain, and placenta. These receptors play a crucial role in iron homeostasis by regulating the uptake of transferrin, an iron-binding protein, into the cells.
Transferrin binds to two ferric ions (Fe3+) in the bloodstream, forming a complex known as holo-transferrin. This complex then interacts with the transferrin receptors on the cell surface, leading to endocytosis of the transferrin-receptor complex into the cell. Once inside the cell, the acidic environment within the endosome causes the release of iron ions from the transferrin molecule, which can then be transported into the cytoplasm for use in various metabolic processes.
After releasing the iron, the apo-transferrin (iron-free transferrin) is recycled back to the cell surface and released back into the bloodstream, where it can bind to more ferric ions and repeat the cycle. This process helps maintain appropriate iron levels within the body and ensures that cells have access to the iron they need for essential functions such as DNA synthesis, energy production, and oxygen transport.
In summary, transferrin receptors are membrane-bound proteins responsible for recognizing and facilitating the uptake of transferrin-bound iron into cells, playing a critical role in maintaining iron homeostasis within the body.
Transferrin is a glycoprotein that binds and transports iron ions in the blood to maintain iron homeostasis, protect against iron-induced oxidative stress, and deliver iron for erythropoiesis.
Transferrin is a glycoprotein that plays a crucial role in the transport and homeostasis of iron in the body. It's produced mainly in the liver and has the ability to bind two ferric (Fe3+) ions in its N-lobe and C-lobe, thus creating transferrin saturation.
This protein is essential for delivering iron to cells while preventing the harmful effects of free iron, which can catalyze the formation of reactive oxygen species through Fenton reactions. Transferrin interacts with specific transferrin receptors on the surface of cells, particularly in erythroid precursors and brain endothelial cells, to facilitate iron uptake via receptor-mediated endocytosis.
In addition to its role in iron transport, transferrin also has antimicrobial properties due to its ability to sequester free iron, making it less available for bacterial growth and survival. Transferrin levels can be used as a clinical marker of iron status, with decreased levels indicating iron deficiency anemia and increased levels potentially signaling inflammation or liver disease.
Neisseria meningitidis is a gram-negative, aerobic diplococcus that can cause life-threatening invasive diseases such as meningitis and septicemia, often residing asymptomatically in the human nasopharynx.
Neisseria meningitidis is a Gram-negative, aerobic, bean-shaped diplococcus bacterium. It is one of the leading causes of bacterial meningitis and sepsis (known as meningococcal disease) worldwide. The bacteria can be found in the back of the nose and throat of approximately 10-25% of the general population, particularly in children, teenagers, and young adults, without causing any symptoms or illness. However, when the bacterium invades the bloodstream and spreads to the brain or spinal cord, it can lead to life-threatening infections such as meningitis (inflammation of the membranes surrounding the brain and spinal cord) and septicemia (blood poisoning).
Neisseria meningitidis is classified into 12 serogroups based on the chemical structure of their capsular polysaccharides. The six major serogroups that cause most meningococcal disease worldwide are A, B, C, W, X, and Y. Vaccines are available to protect against some or all of these serogroups.
Meningococcal disease can progress rapidly, leading to severe symptoms such as high fever, headache, stiff neck, confusion, nausea, vomiting, and a rash consisting of purple or red spots. Immediate medical attention is required if someone experiences these symptoms, as meningococcal disease can cause permanent disabilities or death within hours if left untreated.
Meningococcal meningitis is a severe bacterial infection causing inflammation of the membranes surrounding the brain and spinal cord (meninges), primarily caused by the Neisseria meningitidis bacteria, which can lead to potentially life-threatening complications if not promptly diagnosed and treated.
Meningococcal meningitis is a specific type of bacterial meningitis caused by the bacterium Neisseria meningitidis, also known as meningococcus. Meningitis refers to the inflammation of the meninges, which are the protective membranes covering the brain and spinal cord. When this inflammation is caused by the meningococcal bacteria, it is called meningococcal meningitis.
There are several serogroups of Neisseria meningitidis that can cause invasive disease, with the most common ones being A, B, C, W, and Y. The infection can spread through respiratory droplets or direct contact with an infected person's saliva or secretions, especially when they cough or sneeze.
Meningococcal meningitis is a serious and potentially life-threatening condition that requires immediate medical attention. Symptoms may include sudden onset of fever, severe headache, stiff neck, nausea, vomiting, confusion, and sensitivity to light. In some cases, a rash may also develop, characterized by small purple or red spots that do not blanch when pressed with a glass.
Prevention measures include vaccination against the different serogroups of Neisseria meningitidis, maintaining good personal hygiene, avoiding sharing utensils, cigarettes, or other items that may come into contact with an infected person's saliva, and promptly seeking medical care if symptoms develop.
Meningococcal infections are acute bacterial illnesses caused by the gram-negative diplococcus Neisseria meningitidis, which can manifest as meningitis, septicemia, or less commonly as pneumonia, arthritis, and pericarditis.
Meningococcal infections are caused by the bacterium Neisseria meningitidis, also known as meningococcus. These infections can take several forms, but the most common are meningitis (inflammation of the membranes surrounding the brain and spinal cord) and septicemia (bloodstream infection). Meningococcal infections are contagious and can spread through respiratory droplets or close contact with an infected person. They can be serious and potentially life-threatening, requiring prompt medical attention and treatment with antibiotics. Symptoms of meningococcal meningitis may include fever, headache, stiff neck, and sensitivity to light, while symptoms of septicemia may include fever, chills, rash, and severe muscle pain. Vaccination is available to prevent certain strains of meningococcal disease.
Neisseria meningitidis, Serogroup B is a subtype of the bacterium Neisseria meningitidis that expresses a polysaccharide capsule composed of unique sialic acid residues and can cause invasive meningococcal disease, including meningitis and septicemia.
Neisseria meningitidis, Serogroup B is a subtype of the bacterium Neisseria meningitidis, also known as meningococcus. This bacterium can cause serious infections such as meningitis (inflammation of the lining of the brain and spinal cord) and septicemia (blood poisoning).
Serogroup B is one of the five main serogroups of Neisseria meningitidis, which are classified based on the chemical structure of their capsular polysaccharides. Serogroup B strains are responsible for a significant proportion of invasive meningococcal disease cases in many parts of the world.
The availability of vaccines that protect against some but not all serogroups of Neisseria meningitidis has led to efforts to develop effective vaccines against Serogroup B strains, which have been challenging due to their chemical structure and variability. In recent years, several vaccines targeting Serogroup B have been developed and licensed for use in various countries.
Neisseria meningitidis, Serogroup C is a gram-negative bacterium that can cause invasive meningococcal disease, including meningitis and sepsis, with a distinct polysaccharide capsular antigen enabling serogroup classification, specifically as group C among the five primary serogroups (A, B, C, W, Y).
Neisseria meningitidis, Serogroup C is a type of bacteria that can cause serious infections in humans. It is also known as meningococcus and is part of a group of bacteria called meningococci. These bacteria can be divided into several serogroups based on the chemical structure of their outer coat. Serogroup C is one of these groups and is responsible for causing a significant number of invasive meningococcal diseases worldwide.
The bacterium Neisseria meningitidis, Serogroup C can cause serious infections such as meningitis (inflammation of the membranes surrounding the brain and spinal cord) and septicemia (blood poisoning). These infections can be life-threatening and require prompt medical attention.
The bacteria are spread through close contact with an infected person, such as coughing or kissing. It can also be transmitted through respiratory droplets or saliva. The bacteria can colonize the nasopharynx (the upper part of the throat behind the nose) without causing any symptoms, but in some cases, they can invade the bloodstream and cause serious infections.
Vaccination is available to protect against Neisseria meningitidis, Serogroup C infection. The vaccine is recommended for people at increased risk of infection, such as those traveling to areas where the disease is common or those with certain medical conditions that weaken the immune system.
Neisseria meningitidis, Serogroup W-135 is a gram-negative bacterium that can cause invasive meningococcal disease, including meningitis and sepsis, and is classified under serogroup W based on the chemical structure of its capsular polysaccharide.
Neisseria meningitidis, Serogroup W-135 is a subtype of the bacterium Neisseria meningitidis, also known as meningococcus. This gram-negative diplococcus is a leading cause of bacterial meningitis and sepsis worldwide. The serogroups of N. meningitidis are defined based on the chemical structure of their capsular polysaccharides, which are essential virulence factors.
Serogroup W-135 is one of the six primary serogroups (A, B, C, W, X, and Y) that account for nearly all meningococcal disease cases globally. The W-135 serogroup has been associated with several outbreaks and sporadic cases of meningitis and sepsis, particularly in the African "meningitis belt," which stretches across the continent from Senegal to Ethiopia. However, it can also cause disease in other parts of the world, including Europe, America, and Asia.
The W-135 serogroup has been a concern due to its association with travel and pilgrimages, such as the Hajj in Saudi Arabia. The Hajj-associated meningococcal disease outbreaks led to the introduction of vaccination requirements for international travelers attending the pilgrimage.
Vaccines are available to protect against N. meningitidis Serogroup W-135, and they are often combined with other serogroups (e.g., MenACWY or MenQuad) to provide broader protection against multiple serogroups. These vaccines have been instrumental in controlling outbreaks and reducing the overall burden of meningococcal disease worldwide.
Neisseria meningitidis, Serogroup A is a gram-negative bacterium that can cause invasive meningococcal disease, primarily characterized by meningitis and sepsis, with a polysaccharide capsule composed of alpha (1→6)-linked N-acetylneuraminic acid and N-glycolylneuraminic acid residues.
Neisseria meningitidis, Serogroup A is a subtype of the bacterium Neisseria meningitidis, also known as meningococcus. This bacterium can cause serious infections such as meningitis (inflammation of the lining surrounding the brain and spinal cord) and septicemia (bloodstream infection).
The serogroup A designation refers to the antigenic structure of the polysaccharide capsule that surrounds the bacterium. There are several serogroups of Neisseria meningitidis, including A, B, C, Y, and W. Each serogroup has a distinct polysaccharide capsule, which can be identified using specific antibodies.
Serogroup A Neisseria meningitidis is a significant cause of epidemic meningitis, particularly in the "meningitis belt" of sub-Saharan Africa. Vaccines are available to protect against serogroup A meningococcal disease, and mass vaccination campaigns have been successful in reducing the incidence of epidemics in this region.
List of MeSH codes (D12.776.157)
... bacterial transferrin receptor complex MeSH D12.776.157.905.500.249.500 - transferrin-binding protein a MeSH D12.776.157.905. ... tnf receptor-associated factor 1 MeSH D12.776.157.057.500.750 - tnf receptor-associated factor 2 MeSH D12.776.157.057.500.875 ... tnf receptor-associated factor 3 MeSH D12.776.157.057.500.937 - tnf receptor-associated factor 5 MeSH D12.776.157.057.500.968 ... electron transport complex i MeSH D12.776.157.530.450.250.875.468 - electron transport complex iii MeSH D12.776.157.530.450.250 ...
List of MeSH codes (D12.776.543)
... bacterial transferrin receptor complex MeSH D12.776.543.750.850.249.500 - transferrin-binding protein a MeSH D12.776.543.750. ... receptor-cd3 complex, antigen, t-cell MeSH D12.776.543.750.705.816.824.825 - receptors, antigen, t-cell, alpha-beta MeSH ... receptor, erbb-2 MeSH D12.776.543.750.060.437 - receptor, erbb-3 MeSH D12.776.543.750.060.468 - receptor, igf type 1 MeSH ... receptor, igf type 1 MeSH D12.776.543.750.750.400.780.410 - receptor, igf type 2 MeSH D12.776.543.750.750.400.820 - receptors, ...
Transferrin
... bound to its receptor. Transferrin receptor complex. Transferrin is also associated with the innate immune system. ... It is found in the mucosa and binds iron, thus creating an environment low in free iron that impedes bacterial survival in a ... Two main transferrin receptors found in humans denoted as transferrin receptor 1 (TfR1) and transferrin receptor 2 (TfR2). ... Beta-2 transferrin Transferrin receptor Total iron-binding capacity Transferrin saturation Ferritin Optiferrin recombinant ...
Innate immune system
Increased levels of lactoferrin and transferrin inhibit bacterial growth by binding iron, an essential bacterial nutrient. The ... The binding of bacterial molecules to receptors on the surface of a macrophage triggers it to engulf and destroy the bacteria ... As with animals, plants attacked by insects or other pathogens use a set of complex metabolic responses that lead to the ... Gómez-Gómez L, Boller T (June 2000). "FLS2: an LRR receptor-like kinase involved in the perception of the bacterial elicitor ...
List of MeSH codes (D12.776.124)
... receptors, antigen, b-cell MeSH D12.776.124.486.485.950.500 - antigens, cd79 MeSH D12.776.124.790.106.050 - alpha 1- ... antigen-antibody complex MeSH D12.776.124.486.485.114.301 - antitoxins MeSH D12.776.124.486.485.114.301.138 - antivenins MeSH ... transferrin MeSH D12.776.124.790.651.114.071 - antibodies, anti-idiotypic MeSH D12.776.124.790.651.114.107 - antibodies, ... bacterial MeSH D12.776.124.486.485.114.107.288 - antistreptolysin MeSH D12.776.124.486.485.114.125 - antibodies, bispecific ...
Biosensor
There is very high selectivity for transferrin receptors because they are over-expressed in cancer cells. If cells have high ... Bacterial death rates in these bags were compared with rates in unexposed control bags of the same organism. The bacterial " ... A residue of the AgBP is identified in the neighborhood of the antigen in their complex. This residue is changed into a ... by Quartz crystal microbalances with nanoparticles and transferrin that would potentially attach to transferrin receptors on ...
Lactoferrin
... forms a reddish complex with iron; its affinity for iron is 300 times higher than that of transferrin. The affinity ... The lactoferrin receptor plays an important role in the internalization of lactoferrin; it also facilitates absorption of iron ... Lactoferrin's primary role is to sequester free iron, and in doing so remove essential substrate required for bacterial growth ... Exons of the lactoferrin gene in oxen have a similar size to the exons of other genes of the transferrin family, whereas the ...
Gallium scan
Gallium (III) (Ga3+) binds to transferrin, leukocyte lactoferrin, bacterial siderophores, inflammatory proteins, and cell- ... Somatostatin receptors are overexpressed in many NETs, so that the 68Ga DOTA conjugated peptide is preferentially taken up in ... The gallium-67 is then complexed with citric acid to form gallium citrate. The half-life of gallium-67 is 78 hours. It decays ... and for this reason can be used in leukopenic patients with bacterial infection (here it attaches directly to bacterial ...
Siderophore
The iron(III) complex is then reduced to iron(II) and the iron is transferred to nicotianamine, which although very similar to ... Transferrin is present in the serum at approximately 30 μM, and contains two iron-binding sites, each with an extremely high ... With bacterial vascular diseases, the infection is spread within the plants through the xylem. Once within the plant, the ... Siderophores are then recognized by cell specific receptors on the outer membrane of the cell. In fungi and other eukaryotes, ...
Protein moonlighting
The complex phenotypes of several disorders are suspected to be caused by the involvement of moonlighting proteins. The protein ... Other proteins like bacterial spore coat, a slime mold cyst protein, and epidermis differentiation-specific protein, contain ... Moreover, in case of its iron import activities it can traffic into cells holo-transferrin as well as the related molecule ... Many proteins that moonlight are enzymes; others are receptors, ion channels or chaperones. The most common primary function of ...
Zebrafish
Sex determination of common laboratory strains was shown to be a complex genetic trait, rather than to follow a simple ZW or XY ... In a glucocorticoid receptor-defective mutant with reduced exploratory behavior, fluoxetine rescued the normal exploratory ... D. rerio has three transferrins, all of which cluster closely with other vertebrates. When close relatives mate, progeny may ... Zebrafish models for a wide range of bacterial, viral and parasitic pathogens have already been established; for example, the ...
FepA
... is an integral bacterial outer membrane porin protein that belongs to outer membrane receptor family and provides the ... Both steps occur independently of the TonB-ExbB-ExbD complex and the proton motive force it provides. In the periplasm, FeEnt ... This can also be seen with pathogenic bacteria inside its host, where iron is bound tightly by haemoglobin, transferrin, ... The ferric enterobactin receptor FepA recognises the catecholate part of ferric enterobactin (FeEnt), and transports it across ...
Glyceraldehyde 3-phosphate dehydrogenase
5-trisphosphate receptor to regulate intracellular Ca2+ signaling; Oct-1 to form the coactivator complex OCA-S, which is ... "The macrophage cell surface glyceraldehyde-3-phosphate dehydrogenase is a novel transferrin receptor". The Journal of ... Bacterial GAPDH from Mycoplasma and Streptococcus and fungal GAPDH from Paracoccidioides brasiliensis are known to bind with ... "Characterization of glyceraldehyde-3-phosphate dehydrogenase as a novel transferrin receptor". The International Journal of ...
Human iron metabolism
... also acts as a transferrin receptor. Transferrin-bound ferric iron is recognized by these transferrin receptors, triggering a ... Iron in such complexes can cause damage as described above. To prevent that kind of damage, all life forms that use iron bind ... Although this mechanism is an elegant response to short-term bacterial infection, it can cause problems when it goes on so long ... "Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary ...
Monoclonal antibody
Transferrin, on the other hand, has a pI of 5.9, so it cannot be easily separated by this method. A difference in pI of at ... Every intact antibody can bind to cell receptors or other proteins with its Fc region. MAbs approved by the FDA for cancer ... There may also be bacterial contamination and, as a result, endotoxins that are secreted by the bacteria. Depending on the ... Monoclonal antibodies are more expensive to manufacture than small molecules due to the complex processes involved and the ...
Porphyromonas gingivalis
List of bacterial vaginosis microbiota Naito M, Hirakawa H, Yamashita A, Ohara N, Shoji M, Yukitake H, et al. (August 2008). " ... P. gingivalis can also degrade transferrin within host cells which provides the organism with an abundant iron source needed to ... January 2011). "The C5a receptor impairs IL-12-dependent clearance of Porphyromonas gingivalis and is required for induction of ... be associated with modulating β2 integrin adhesive activity for uptake by monocytes using the CD14/TLR2/PI3K signaling complex ...
List of MeSH codes (D12.776)
... receptor, erbb-2 MeSH D12.776.624.664.700.790 - receptor, erbb-3 MeSH D12.776.624.664.700.800 - receptor, macrophage colony- ... electron transport complex iii MeSH D12.776.556.579.374.375.977 - nitrate reductase (nad(p)h) MeSH D12.776.556.579.374.375.988 ... transferrin MeSH D12.776.377.715.548.114 - antibodies MeSH D12.776.377.715.548.114.071 - antibodies, anti-idiotypic MeSH ... D12.776.377.715.548.114.107 - antibodies, archaeal MeSH D12.776.377.715.548.114.125 - antibodies, bacterial MeSH D12.776. ...
Canine parvovirus
... the canine transferrin receptor. CPV2 has a high rate of evolution, possibly due to a rate of nucleotide substitution that is ... The fluids are typically a mix of a sterile, balanced electrolyte solution, with an appropriate amount of B-complex vitamins, ... Bacterial myocarditis has also been reported secondarily to sepsis. Dogs with CPV are at risk of intussusception, a condition ... and the success of new strains seems to depend on extending the range of hosts affected and improved binding to its receptor, ...
Zinc
Complexes of zinc are mostly 4- or 6- coordinate, although 5-coordinate complexes are known. Zinc(I) compounds are very rare. ... In blood plasma, zinc is bound to and transported by albumin (60%, low-affinity) and transferrin (10%). Because transferrin ... The U.S. Food and Drug Administration (FDA) states that zinc damages nerve receptors in the nose, causing anosmia. Reports of ... One reported case of chronic ingestion of 425 pennies (over 1 kg of zinc) resulted in death due to gastrointestinal bacterial ...
Zinc in biology
In blood plasma, zinc is bound to and transported by albumin (60%, low-affinity) and transferrin (10%). Because transferrin ... including complex I, complex III, and α-ketoglutarate dehydrogenase), the dysregulation of calcium homeostasis, glutamatergic ... ISBN 978-1-4288-1893-4. Hershfinkel, M; Silverman WF; Sekler I (2007). "The Zinc Sensing Receptor, a Link Between Zinc and Cell ... "The Role of Copper and Zinc Toxicity in Innate Immune Defense against Bacterial Pathogens". The Journal of Biological Chemistry ...
Drosophila melanogaster
... including both soluble receptors and cell surface receptors (PGRP-LE and LC, respectively). Imd signalling culminates in the ... Disruption of the complex by mutations in either the PDZ domains or the target proteins reduces the efficiency of signaling. ... There are three transferrin orthologs, all of which are dramatically divergent from those known in chordate models. A March ... The transposable P elements, also known as transposons, are segments of bacterial DNA that are transferred into the fly genome ...
Ferritin
... iron is stored in a protein complex as ferritin or the related complex hemosiderin. Apoferritin binds to free ferrous iron and ... H and M subunits of eukaryotic ferritin and all subunits of bacterial and archaeal ferritin are H-type and have ferroxidase ... Mizuno S, Mihara T, Miyaoka T, Inagaki T, Horiguchi J (March 2005). "CSF iron, ferritin and transferrin levels in restless legs ... Experimental COVID-19 vaccines have been produced that display the spike protein's receptor binding domain on the surface of ...
Colostrum
Staley, T. E.; Bush, L. J. (January 1985). "Receptor Mechanisms of the Neonatal Intestine and Their Relationship to ... The iron-binding glycoproteins lactoferrin and transferrin in bovine colostrum assist in attacking pathogens by impacting their ... "due to tremendous bacterial loads". Salmonella was also detected in 15% of unpasteurised samples. Pasteurisation reduces the ... with irregular oral intake of complex milk nutrients through the gastrointestinal tract. This transition puts high demands on ...
Outline of immunology
Receptor mediated Graves' disease Myasthenia gravis Type 3 hypersensitivity / Immune complex Foreign Henoch-Schönlein purpura ... C-reactive protein Ceruloplasmin C3 Ferritin Fibrin Haptoglobin Hemopexin Orosomucoid Negative Serum albumin Transferrin ... Post-streptococcal glomerulonephritis Serum sickness Arthus reaction Autoimmune Systemic lupus erythematosus Subacute bacterial ... Anaphylatoxin receptors C3a receptor C5a receptor (CD88) C5AR2 Fc receptor Fc-gamma receptors (FcγR) FcγRI (CD64) FcγRIIA ( ...
Nephrotic syndrome
Spontaneous bacterial peritonitis can develop where there is ascites present. This is a frequent development in children but ... Anaemia (iron resistant microcytic hypochromic type) may be present due to transferrin loss. Dyspnea may be present due to ... "Podocyte protease activated receptor 1 stimulation in mice produces focal segmental glomerulosclerosis mirroring human disease ... "Mutations in multiple components of the nuclear pore complex cause nephrotic syndrome". Journal of Clinical Investigation. 128 ...
Index of oncology articles
... estrogen receptor - estrogen receptor negative - estrogen receptor positive - estrogen receptor test - estrogen replacement ... bacterial toxin - barium enema - barium solution - barium swallow - Barrett's esophagus - basal cell - basal cell carcinoma - ... transferrin-CRM107 - transitional cell - transitional cell carcinoma - transperineal biopsy - transrectal biopsy - transrectal ... boronophenylalanine-fructose complex - bortezomib - Bowen's disease - BPH - brachial plexopathy - brachial plexus - ...
Saliva testing
Streckfus C, Bigler L, Tucci M, Thigpen JT (2000). "A preliminary study of CA15-3, c-erbB-2, epidermal growth factor receptor, ... In 2010 Jou, et al., found that patients diagnosed with oral squamous cell carcinoma had elevated levels transferrin in saliva ... Matsubara K, Irie T, Uekama K (February 1997). "Spectroscopic characterization of the inclusion complex of a luteinizing ... either by spitting or interrupting the bioconversion of dietary nitrate to nitrite in the mouth with anti-bacterial mouthwash, ...
Receptors, Transferrin | Profiles RNS
Bacterial Transferrin Receptor Complex. publications Timeline , Most Recent This graph shows the total number of publications ... written about "Receptors, Transferrin" by people in this website by year, and whether "Receptors, Transferrin" was a major or ... "Receptors, Transferrin" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Below are the most recent publications written about "Receptors, Transferrin" by people in Profiles. ...
List of MeSH codes (D12.776.157) - Wikipedia
... bacterial transferrin receptor complex MeSH D12.776.157.905.500.249.500 - transferrin-binding protein a MeSH D12.776.157.905. ... tnf receptor-associated factor 1 MeSH D12.776.157.057.500.750 - tnf receptor-associated factor 2 MeSH D12.776.157.057.500.875 ... tnf receptor-associated factor 3 MeSH D12.776.157.057.500.937 - tnf receptor-associated factor 5 MeSH D12.776.157.057.500.968 ... electron transport complex i MeSH D12.776.157.530.450.250.875.468 - electron transport complex iii MeSH D12.776.157.530.450.250 ...
DeCS
Bacterial Transferrin Receptor Complex Entry term(s). Transferrin Binding Protein Complex, Bacterial Transferrin-Binding ... Transferrin Binding Protein Complex, Bacterial. Transferrin-Binding Protein Complex, Bacterial. Tree number(s):. D12.776. ... Bacterial Transferrin Receptor Complex - Preferred Concept UI. M0404226. Scope note. A complex of proteins that forms a ... A complex of proteins that forms a receptor for TRANSFERRIN in BACTERIA. Many pathogenic bacteria utilize the transferrin- ...
MH DELETED MN ADDED MN
Bacterial Secretion Systems G6.99.112.104 D5.500.890.500 G6.590.110.104 Bacterial Transferrin Receptor Complex D12.776.97.141 ... Receptor, ErbB-2 D23.101.840.642 D23.101.140.642 Receptor, ErbB-3 D23.101.840.721 D23.101.140.721 Receptor, ErbB-4 D23.101. ... Receptor, Adenosine A1 D12.776.543.750.810.700.100 Receptor, Adenosine A2A D12.776.543.750.810.700.200.100 Receptor, Adenosine ... Receptor, Notch2 D12.776.930.670.750 D12.776.930.770.750 Receptor, PAR-1 D12.776.543.750.705.675.892.790 Receptor, Serotonin, 5 ...
MH DELETED MN ADDED MN
Bacterial Secretion Systems G6.99.112.104 D5.500.890.500 G6.590.110.104 Bacterial Transferrin Receptor Complex D12.776.97.141 ... Receptor, ErbB-2 D23.101.840.642 D23.101.140.642 Receptor, ErbB-3 D23.101.840.721 D23.101.140.721 Receptor, ErbB-4 D23.101. ... Receptor, Adenosine A1 D12.776.543.750.810.700.100 Receptor, Adenosine A2A D12.776.543.750.810.700.200.100 Receptor, Adenosine ... Receptor, Notch2 D12.776.930.670.750 D12.776.930.770.750 Receptor, PAR-1 D12.776.543.750.705.675.892.790 Receptor, Serotonin, 5 ...
MH DELETED MN ADDED MN
Bacterial Secretion Systems G6.99.112.104 D5.500.890.500 G6.590.110.104 Bacterial Transferrin Receptor Complex D12.776.97.141 ... Receptor, ErbB-2 D23.101.840.642 D23.101.140.642 Receptor, ErbB-3 D23.101.840.721 D23.101.140.721 Receptor, ErbB-4 D23.101. ... Receptor, Adenosine A1 D12.776.543.750.810.700.100 Receptor, Adenosine A2A D12.776.543.750.810.700.200.100 Receptor, Adenosine ... Receptor, Notch2 D12.776.930.670.750 D12.776.930.770.750 Receptor, PAR-1 D12.776.543.750.705.675.892.790 Receptor, Serotonin, 5 ...
MH DELETED MN ADDED MN
Bacterial Processes G6.99.112 G6.590.110 Bacterial Shedding G7.700.85 G7.75 Bacterial Transferrin Receptor Complex D12.776. ... Receptors, Transferrin D12.776.543.750.800 Receptors, Tumor Necrosis Factor, Member 14 D12.776.543.750.925.850 D12.776.543.750. ... Receptor Aggregation G4.299.780 G4.774 Receptor Cross-Talk G4.299.785 G4.794 Receptor Protein-Tyrosine Kinases D12.776.543.750. ... 60 D12.776.543.750.630 Receptor Tyrosine Kinase-like Orphan Receptors D12.776.543.750.60.233 D12.776.543.750.630.233 Receptor, ...
MH DELETED MN ADDED MN
Bacterial Processes G6.99.112 G6.590.110 Bacterial Shedding G7.700.85 G7.75 Bacterial Transferrin Receptor Complex D12.776. ... Receptors, Transferrin D12.776.543.750.800 Receptors, Tumor Necrosis Factor, Member 14 D12.776.543.750.925.850 D12.776.543.750. ... Receptor Aggregation G4.299.780 G4.774 Receptor Cross-Talk G4.299.785 G4.794 Receptor Protein-Tyrosine Kinases D12.776.543.750. ... 60 D12.776.543.750.630 Receptor Tyrosine Kinase-like Orphan Receptors D12.776.543.750.60.233 D12.776.543.750.630.233 Receptor, ...
Plus it
... reported that lcn2 containing the iron complex of the bacterial siderophore donates iron to cells via the lcn2 receptor (lcn2R/ ... The donation of iron to the cell leads to a decrease in transferrin receptor (TfR1) expression and an increase in ferritin ... Internalization of lcn2 and its receptor leads to the uptake of iron from the siderophore-iron complex. ... The expression of the lcn2 receptor (lcn2R/24p3R) that has been shown to mediate lcn2-induced cell death (Devireddy et al., ...
Adhesins, Bacterial | Profiles RNS
Bacterial Outer Membrane Proteins. *Adhesins, Bacterial. *Bacterial Transferrin Receptor Complex. *Fimbriae Proteins ... Most fimbriae (FIMBRIAE, BACTERIAL) of gram-negative bacteria function as adhesins, but in many cases it is a minor subunit ... "Adhesins, Bacterial" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... This graph shows the total number of publications written about "Adhesins, Bacterial" by people in this website by year, and ...
MeSH Browser
Bacterial Transferrin Receptor Complex [D12.776.097.120.300] * Fimbriae Proteins [D12.776.097.120.425] ... Bacterial Proteins [D12.776.097] * Antigens, Bacterial [D12.776.097.025] * Adhesins, Bacterial [D12.776.097.025.050] * Adhesins ... Bacterial Proteins [D12.776.097] * Bacterial Outer Membrane Proteins [D12.776.097.120] * Adhesins, Bacterial [D12.776.097.120. ... Adhesin, Bacterial Adhesins, Fimbrial Bacterial Adhesin Bacterial Adhesins Fimbrial Adhesins Registry Number. 0. Previous ...
Neisseria meningitidis Serogroup X in Sub-Saharan Africa - Volume 22, Number 4-April 2016 - Emerging Infectious Diseases...
Maiden MC, van Rensburg MJ, Bray JE, Earle SG, Ford SA, Jolley KA, MLST revisited: the gene-by-gene approach to bacterial ... The hemoglobin receptor is detected more frequently among isolates involved with disease than among those involved with ... We tested the virulence of these isolates in a relevant animal model, transgenic mice expressing the human transferrin (13). ... lacked the hpuA and hpuB genes that mediate heme-iron acquisition from hemoglobin and hemoglobin-haptoglobin complexes. However ...
SCMM Research Project | Welcome to Jawaharlal Nehru University
"Studies on regulation of mammalian iron transporter transferrin receptor by catecholamines". Council of Scientific and ... National Biosciences Award to work on project entitled "Functional characterization of unique bacterial gyrase in the malaria ... of DNA replication and non-replication function of two putative homologues of Plasmodium falciparum Origin Recognition Complex ... Investigation on regulation of transferrin receptor by insulin. Indian Council of Medical Research (2007-09). ...
Cancers | Free Full-Text | ACAP1 Deficiency Predicts Inferior Immunotherapy Response in Solid Tumors
... such as transferrin receptor and integrin β1 (CD29) [8,9,10,11]. Cell surface transferrin receptor is required for B and T cell ... It also interacts with Akt to form a protein complex, acting as an adaptor for the endocytic recycling of intracellular cargos ... It also binds to NOD1/NOD2 and then inhibits NF-κB activation in response to the stimulation of bacterial components in ... Neckers, L.M.; Yenokida, G.; James, S.P. The role of the transferrin receptor in human B lymphocyte activation. J. Immunol. ...
Pesquisa | Biblioteca Virtual em Saúde - BRASIL
Pathogenic bacteria exploit transferrin receptor transcytosis to penetrate the blood-brain barrier. ... complex on BCVs to authenticate the precise recognition and selection of TfR vesicles to fuse with and facilitate bacterial ... Toll-like receptor signals emanating from bacteria-containing vesicles (BCVs) trigger K33-linked polyubiquitination at Lys168 ... Meningitis is among the most serious diseases, but the mechanisms by which major meningitis-causing bacterial pathogens cross ...
NOD2 Antibody (2D9) - BSA Free (NB100-524): Novus Biologicals
Transferrin and the blood brain barrier. Transferrin, an iron binding protein that facilitates iron uptake in cells, is an ... After interacting with CARD-CARD, NOD2 may bind/activate RIP2/RICK and this active NOD2:RIP2 complex then stimulates MAPK (JNK ... NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation. Nat. Med. Dec 6 ... Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) is an intracellular pattern recognition receptor (PRR) ...
Frontiers | Hacker within! Ehrlichia chaffeensis Effector Driven Phagocyte Reprogramming Strategy
The mechanisms involve induction of transferrin receptor expression on the surface and disruption of Janus kinase (Jak) and ... PcG proteins fall into two functionally distinct protein complexes, Polycomb repressive complex (PRC) 1 and 2, and are involved ... It is established that bacterial pathogens exploit host PTM machinery to promote bacterial survival and replication. Many ... 2) Both ehrlichial TRPs and Wnt5a can interact with the unknown receptor and LRP6 co-receptor and activate canonical Wnt ...
Bacteriocins | Profiles RNS
Metallocene-based bioactive agents
... suggesting that the labelled protein could be transported via the transferrin receptor. Overall, the work in this thesis ... The ligands of the compounds show promising cytotoxicity and selectivity, whereas the bimetallic complexes are less active, but ... the compounds showed little activity against a panel of bacterial pathogens. This suggested a fundamental harmacological issue ... The first study utilizes Fc as a bridge between two biologically-active molecules, biotin, a receptor targeting moiety, and ...
SH3YL1 cooperates with ESCRT-I in the sorting and degradation of the EGF receptor | Journal of Cell Science | The Company of...
Mouse anti-transferrin receptor monoclonal antibody (H68.4; 1:100) was from Zymed Laboratories. Mouse anti-DYKDDDDK (FLAG) ... whereas others such as mannose 6-phosphate receptors and some bacterial toxins enter the trans-Golgi network. In the third ... In this study, we confirmed a previous finding that a component of the ESCRT-I complex, Vps37B, is a binding partner of SH3YL1 ... 1A, lower panels). In contrast, SH3YL1-mCherry did not overlap with transferrin receptor, a recycling endosome marker (Fig. S1A ...
Shigella Infection: Practice Essentials, Pathophysiology, Etiology
The receptor-holotoxin complex is endocytosed.. * The complex moves to Golgi apparatus and then to the endoplasmic reticulum. ... Bacterial shedding usually ceases within 4 weeks of the onset of illness; rarely, it can persist for months. Appropriate ... transferrin and lactoferrin). Many bacteria can secrete iron chelating compounds, or siderophores, which chelate iron from the ... Treatment of bacterial enteritis. Pediatr Infect Dis J. 1998 May. 17(5):420-1. [QxMD MEDLINE Link]. ...
Natural combinatorial genetics and prolific polyamine production enable siderophore diversification in Serratia plymuthica |...
Bacterial siderophores are small molecules with unmatched capacity to scavenge iron from proteins and the extracellular milieu ... The ability of bacteria to synthesize proprietary siderophores may have increased bacterial evolutionary fitness; one way that ... Knocking out SchF0, an enzyme involved in the assembly of enterobactin alone, significantly reduced bacterial fitness. This ... study shows the natural occurrence of serratiochelins, photobactin, enterobactin, and aerobactin in a single bacterial species ...
October | 2021 | DNA-PK Cell Signaling
Together with its putative receptor, receptor for advanced glycation end product, we demonstrate their check details ... Complex patterns of DNA binding were noted for extended PBD dimers. Modelling of DNA strand cross-linking by PBD dimers ... "Upregulation of Zip14 contributes to hepatic zinc (Zn) and non-transferrin-bound iron (Fe) uptake during infection and ... activity of PBD-biaryl conjugates was determined by inability to excise covalently bound drug molecules from bacterial duplex ...
Patent Docs: August 2022
Examples of such genes include bacterial-recognizing Toll-like receptors TLR4 and TLR5 and within these genes site proximal to ... Another important adaptation is the capacity to withstand hypoxic conditions, and in this regard the transferrin receptor 1 ... Penguin Genetics Suggests Complex History. By Kevin E. Noonan --. Penguins are unique among bird species, having lost the ... Finally, the transferrin gene has undergone positive selection in penguins, which the authors speculate reflects resistance to ...
Moraxella catarrhalis Infection: Background, Pathophysiology and Etiology, Epidemiology
M catarrhalis also expresses specific proteins for iron uptake that act as receptors for transferrin and lactoferrin. ... Bacterial infection in chronic obstructive pulmonary disease in 2000: a state-of-the-art review. Clin Microbiol Rev. 2001 Apr. ... produce a protein that confers resistance to complement by interfering with the formation of the membrane attack complex. ... Efficacy and safety of moxifloxacin for community-acquired bacterial pneumonia based on pharmacokinetic analysis. J Infect ...
Ultrasound Microbubble Treatment Enhances Clathrin-Mediated Endocytosis and Fluid-Phase Uptake through Distinct Mechanisms |...
Tracking the abundance of TfR on the cell surface and the internalization of its ligand transferrin revealed that USMB acutely ... for the internalization of receptor-bound macromolecules such as Transferrin Receptor (TfR), and distinct mechanism(s) that ... These studies have revealed a complex regulation of cargo receptor and CCP dynamics by lipids such as phosphatidic acid [18], ... a bacterial pore-forming toxin. Ca2+ influx through SLO pores leads to lysosome exocytosis, part of the repair mechanism ...
Glycan Profiling | LecChip - Lectin Microarray | GK-LECCHIP | Biomedica
bi-antennary complex-type N-glycan with outer Gal and bisecting GlcNAc, no affinity for fully sialylated N-type ... A unique N-glycan on human transferrin in CSF: a possible biomarker for iNPH. S. Futakawa, K. Nara, M. Miyajima, A. Kuno, H. ... Binding sugars: from natural lectins to synthetic receptors and engineered neolectins.. Arnaud, J., Audfray, A., Imberty, A., ... Lectin microarray reveals binding profiles of Lactobacillus casei strains in a comprehensive analysis of bacterial cell wall ...
Medicinal & Biomolecular Chemistry - McMaster Experts
Hydrophobic Interactions in Complexes of Antimicrobial Peptides with Bacterial Polysaccharides Journal Articles ... Dopamine receptor modulation by Pro-Leu-Gly-NH2 analogs possessing cyclic amino acid residues at the C-terminal position ... HUMAN TRANSFERRIN, ASIALOTRANSFERRIN AND THE INTERMEDIATE FORMS Journal Articles * High throughput screening identifies novel ... Single amino acid chelate complexes of the M(CO)3+ core for correlating fluorescence and radioimaging studies (M = 99mTc or Re) ...
Pediatric Common Variable Immunodeficiency Workup: Laboratory Studies, Imaging Studies, Other Tests
... transferrin receptors (CD71), and major histocompatibility complex (MHC) class II molecules (HLA-DR). Detection of activation ... Bacteriophage PhiX174 (a bacterial virus noninfective in humans) has been shown to be a potent, safe, and useful antigen; it ... Salzer U, Grimbacher B. TACItly changing tunes: farewell to a yin and yang of BAFF receptor and TACI in humoral immunity? New ... Reduced class-switched memory B cells; hypogammaglobulinemia; reduced binding of C3d-containing immune complexes and EBV-gp350 ...
Mechanism Of Pathogenicity - Blog
Catecholamine stress hormones are in a position to bind transferrin and lactoferrin, to kind direct complexes with ferric iron ... This capability of stress hormones to mediate bacterial iron acquisition from transferrin and lactoferrin has been proposed to ... Endotoxin recognition molecules MD-2 and toll-like receptor 4 also may be thought-about as potential targets for therapeutic ... Gonococcal transferrin-binding protein 2 facilitates however just isnt essential for transferrin utilization. The iron-binding ...
BACTERIALactoferrinClathrin-mediated endocytosisProteinsUptakeAdhesinsBiologically activeLigandBindEscherichiaPutativeSerumDescriptorNeisseriaFerritinAntagonistsPathogensCharacterizationInsulinIsolatesVitroSpeciesStructuralMechanismChromatinDrugsTherapeuticInfectionsHelicobacterCellMoietiesImmuneSurvivalStudyCellsBindingMechanismsStructureHumanActiveInvolvesMajorFormationDiverseComponentsRoleActivation
BACTERIA8
- A complex of proteins that forms a receptor for TRANSFERRIN in BACTERIA. (bvsalud.org)
- Many pathogenic bacteria utilize the transferrin-binding complex to acquire their supply of iron from serum. (bvsalud.org)
- Cell-surface components or appendages of bacteria that facilitate adhesion (BACTERIAL ADHESION) to other cells or to inanimate surfaces. (wakehealth.edu)
- Most fimbriae (FIMBRIAE, BACTERIAL) of gram-negative bacteria function as adhesins, but in many cases it is a minor subunit protein at the tip of the fimbriae that is the actual adhesin. (wakehealth.edu)
- They are protein or lipopolysaccharide-protein complexes used in taxonomy studies of bacteria. (uams.edu)
- Some bacteria have evolved extraordinary ways to synthesize proprietary siderophores that require the expression of specialized TonB-dependent receptors (TBDRs) to allow for efficient siderophore uptake by the producer and its relatives [ 15 ]. (biomedcentral.com)
- It is best in case of planktonic micro organism and less efficient in the eradicating of encapsulated bacteria and bacterial L-varieties. (wagergun.com)
- It induces both local effects in the gut, as well as alterations in distant organs through stimuli generated by bacteria, structural bacterial components, and microbial metabolites [ 7 ]. (biomedcentral.com)
Lactoferrin6
- M catarrhalis also expresses specific proteins for iron uptake that act as receptors for transferrin and lactoferrin. (medscape.com)
- Catecholamine stress hormones are in a position to bind transferrin and lactoferrin, to kind direct complexes with ferric iron, and to scale back ferric to ferrous iron with subsequent liberation from transferrin (Sandrini et al. (wagergun.com)
- This capability of stress hormones to mediate bacterial iron acquisition from transferrin and lactoferrin has been proposed to perform in biofilm formation in intravenous lines by the Gram-optimistic bacterium S. (wagergun.com)
- Lactoferrin binding protein B (LbpB) is a bi-lobed outer membrane-bound lipoprotein that comprises part of the lactoferrin (Lf) receptor complex in Neisseria meningitidis and other Gram-negative pathogens. (ucalgary.ca)
- Lactoferrin that was not bound to its cognate receptor was able to bind and neutralize lipopolysaccharide. (springer.com)
- Lactoferrin (Lf) is an 80-kDa glycoprotein that belongs to the transferrin family and is abundant in the colostrum and milk of mammals. (springer.com)
Clathrin-mediated endocytosis1
- Cells constitutively utilize several distinct mechanisms of endocytosis, including clathrin-mediated endocytosis (CME) for the internalization of receptor-bound macromolecules such as Transferrin Receptor (TfR), and distinct mechanism(s) that mediate the majority of fluid-phase endocytosis. (plos.org)
Proteins4
- Despite its small genome and limited number of effector proteins, Ehrlichia efficiently establishes an intracellular infection and avoids immune defenses in vertebrate and invertebrate hosts through complex molecular and cellular reprogramming strategies. (frontiersin.org)
- Bacterial siderophores are small molecules with unmatched capacity to scavenge iron from proteins and the extracellular milieu, where it mostly occurs as insoluble Fe 3+ . (biomedcentral.com)
- In eukaryotic cells, chromatin comprises a complex consisting of DNA, RNA, and proteins where covalent modifications correlate with regulation of gene expression [ 1 ]. (biomedcentral.com)
- I am also interested in determining the electrochemical properties of proteins, containing redox active metal centers (Hemoglobin, myoglobin, Hemoglobin-haptoglobin complex etc.) using spectroelectrochemical technique. (ecu.edu)
Uptake2
- 2010). Free iron can then be used for bacterial development through other specific iron uptake techniques. (wagergun.com)
- Upon Fe3+ uptake, transferrins undergo a large scale conformational transition: the apo structure with an opening of the interdomain cleft is transformed into the closed holo structure, implying initial Fe3+ binding in the open form. (lookformedical.com)
Adhesins3
- Adhesins, Bacterial" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)
- This graph shows the total number of publications written about "Adhesins, Bacterial" by people in this website by year, and whether "Adhesins, Bacterial" was a major or minor topic of these publications. (wakehealth.edu)
- Below are the most recent publications written about "Adhesins, Bacterial" by people in Profiles. (wakehealth.edu)
Biologically active2
- Mass spectrometry-guided optimization and characterization of a biologically active transferrin-lysozyme model drug conjugate. (umassmed.edu)
- The first study utilizes Fc as a bridge between two biologically-active molecules, biotin, a receptor targeting moiety, and chlorambucil, a chemotherapeutic, to give a novel trifunctional anticancer compound. (sfu.ca)
Ligand4
- They specifically bind iron-bearing transferrin, are endocytosed with its ligand and then returned to the cell surface where transferrin without its iron is released. (umassmed.edu)
- Tracking the abundance of TfR on the cell surface and the internalization of its ligand transferrin revealed that USMB acutely enhances the rate of CME. (plos.org)
- tight TCF7 results among the several centrosomes been in ligand PER give the T of gradient complex, on both the signaling and docking sphingolipids, at a DNA modification addition. (erik-mill.de)
- Taking advantage of the diverse γδ TCR repertoire or other ligand-receptor interactions, γδ T cells can recognize a broad spectrum of tumor-associated antigens (TAAs) in a major histocompatibility complex (MHC)-independent manner, thereby activating downstream pleiotropic effects. (explorationpub.com)
Bind1
- IRPs bind to IREs when iron levels are depleted, resulting in either inhibition of translation of ferritin mRNA and of other transcripts that contain an IRE in the 5′-untranslated regions (UTR) or stabilization of the transferrin receptor mRNA and possibly other transcripts that contain IREs in the 3′ UTR. (nih.gov)
Escherichia1
- We adapted a broth microdilution method for determining chlorhexidine MICs, poured panels, established quality control ranges, and tested Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, and Enterobacter cloacae complex isolates collected at three U.S. sites. (cdc.gov)
Putative2
- Programme Support on Molecular Parasitology" to work on the project entitled "Characterization of DNA replication and non-replication function of two putative homologues of Plasmodium falciparum Origin Recognition Complex" Department of Biotechnology (DBT) (2011-2016). (jnu.ac.in)
- Together with its putative receptor, receptor for advanced glycation end product, we demonstrate their check details involvement in TNT direction guidance. (nartpathway.com)
Serum3
- The fourth type of metallocene conjugate in this work installed ruthenocene-like tags to aromatic amino-acid side chains of human serum transferrin. (sfu.ca)
- In this study, we evaluated serum hepcidin, transferrin saturation, ferritin, IL-6, IL-1, and hemoglobin levels in M. arthritidis injected C3H/HeJ (TLR2 +/+ , TLR4 -/- ) mice and C3H/HeSnJ (TLR2 +/+ , TLR4 +/+ ) mice over a 21 day period. (biomedcentral.com)
- Both mice had an increase in serum ferritin but a decrease in serum transferrin saturation. (biomedcentral.com)
Descriptor1
- Receptors, Transferrin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
Neisseria1
- Whole-genome sequencing of Neisseria meningitidis serogroup X isolates from sub-Saharan Africa and Europe showed that serogroup X emergence in sub-Saharan Africa resulted from expansion of particular variants within clonal complex 181. (cdc.gov)
Ferritin3
- IRP binding stabilizes the mRNA that encodes the transferrin receptor and represses the translation of transcripts that contain IREs near the 5′ end of the ferritin H and L chains. (nih.gov)
- In previous years, our laboratory identified and characterized the cis and trans elements mediating iron-dependent alterations in the abundance of ferritin and the transferrin receptor. (nih.gov)
- IREs are RNA stem-loops found in the 5′ end of ferritin mRNA and the 3′ end of transferrin receptor mRNA. (nih.gov)
Antagonists1
- Tyagi R.K. Mechanisms of inhibition of transcriptional activity of androgen receptor by antagonists/endocrine disruptors CSIR , (2003-2006). (jnu.ac.in)
Pathogens1
- Despite a design that aimed to allow the quinolone activity to be unencumbered by the Fc group, while allowing for ROS generation, the compounds showed little activity against a panel of bacterial pathogens. (sfu.ca)
Characterization1
- National Biosciences Award to work on project entitled "Functional characterization of unique bacterial gyrase in the malaria parasite Plasmodium falciparum with codon optimization and screening some novel gyrase inhitors" Department of Biotechnology (DBT) (2011-2014). (jnu.ac.in)
Insulin1
- Investigation on regulation of transferrin receptor by insulin. (jnu.ac.in)
Isolates2
- Cyclic epidemics spanned the meningitis belt and were caused mainly by isolates of N. meningitidis serogroup A that belonged to several genetic lineages called clonal complexes (CCs). (cdc.gov)
- Chlorhexidine MICs were determined for 535 isolates including 129 S. aureus, 156 E. coli, 142 K. pneumoniae, and 108 E. cloacae complex isolates. (cdc.gov)
Vitro1
- Although the transfection efficiency of chitosan-DNA microparticles was typically lower than that of DNA complexed with lipid-based reagents, in vitro transfection results indicated that HEK293 cells take up chitosan-DNA microparticles more efficiently compared to HeLa and mouse fibroblastic 3T3 cell lines. (ualberta.ca)
Species2
- This study shows the natural occurrence of serratiochelins, photobactin, enterobactin, and aerobactin in a single bacterial species and illuminates the interplay between siderophore biosynthetic pathways and polyamine production, indicating routes of molecular diversification. (biomedcentral.com)
- Sickness behavior is a behavioral complex that is typically induced by acute infections and tissue injury in many mammalian species. (biomedcentral.com)
Structural3
- Alternative structural state of transferrin. (lookformedical.com)
- Relative to its homolog, transferrin-binding protein B (TbpB), there currently is little evidence for its role in iron acquisition and relatively little structural and biophysical information on its interaction with Lf. (ucalgary.ca)
- γδ T cells express unique T cell receptor (TCR) γ and TCR δ chains, with structural and functional heterogeneity. (explorationpub.com)
Mechanism2
- Transferrins, the mechanism of iron release by ovotransferrin. (lookformedical.com)
- In the structure, both empty iron binding clefts are in the open conformation, lending weight to the theory that Fe(3+) binding or release in transferrin proceeds via a mechanism that involves domain opening and closure. (lookformedical.com)
Chromatin1
- Studies to decipher the functional implications of nuclear receptors docking onto the mitotic chromatin" Council of Scientific and Industrial Research (CSIR) , (2010-13). (jnu.ac.in)
Drugs3
- The assembled CPV-like nanoparticles were found to withstand conjugation with chemotherapeutic drugs, remain intact following their purification and internalise within 2 hours through TfRs receptors. (biomedcentral.com)
- Traditional strategies towards the tissue-specific drug delivery utilise cytotoxic drugs attached to targeting moieties (e.g. towards TfRs receptors mediating cell-specific targeting and internalisation). (biomedcentral.com)
- Misuse and overuse of antimicrobials in the treatment of human diseases and in animal husbandry can lead to bacterial resistance against clinically relevant drugs [ 4 ]. (hindawi.com)
Therapeutic1
- Tyagi RK, Modulatory effects of herbal drug ingredient(s) on transcription factor Pregnane & Xenobiotic Receptor (PXR): Evaluation for therapeutic potency and health safety assessment. (jnu.ac.in)
Infections3
- Cytopathic results are changes in host cells due toA) viral infections.B) protozoan infections.C) fungal infections.D) bacterial infections.E) helminthic infections. (wagergun.com)
- Most of the classes of antibiotics used for the treatment of bacterial infections in humans are also used in animals [ 3 ]. (hindawi.com)
- Sickness behavior is a behavioral complex induced by infections and immune trauma and mediated by pro-inflammatory cytokines. (biomedcentral.com)
Helicobacter1
- Helicobacter pylori is a gram-negative spiral bacterial, has been associated with peptic ulcers, gastritis, duodenitis, and is believed to be the causative agent of gastric cancer. (walshmedicalmedia.com)
Cell3
- M. arthritidis mitogen (MAM), a superantigen produced by M. arthritidis , activates T cells by forming a complex between the major histocompatability complex II on antigen presenting cells and the T cell receptor on CD4+ T lymphocytes. (biomedcentral.com)
- MAM superantigen activates T cells by forming a complex between the major histocompatability complex (MHC) II molecule on antigen presenting cells and the Vβ chain segments of the T cell receptor (TCR) on CD4+T cells [ 1 ]. (biomedcentral.com)
- Efforts have been made to increase drug carrier targeting efficiency by attaching cell receptor-targeted ligands to the particle surface [ 7 ]. (biomedcentral.com)
Moieties1
- In the second study, Fc and receptor targeting moieties, biotin or estrone, were appended to an antimetastatic Ru(III) scaffold. (sfu.ca)
Immune2
- In this study, we have constructed and analysed an immune transcriptome following bacterial challenge of the Indian tasar wild silkmoth, Antheraea mylitta , an economically important lepidopteran cultivated for silk production. (biomedcentral.com)
- MAM is a unique superantigen in that it also interacts with Toll like receptor (TLR) 4 and 2 found on cells of the innate immune system [ 2 ]. (biomedcentral.com)
Survival1
- Iron is essential for bacterial survival. (biomedcentral.com)
Study2
- Mass spectrometry study of a transferrin-based protein drug reveals the key role of protein aggregation for successful oral delivery. (umassmed.edu)
- In this study, a combination of crosslinking and deuterium exchange coupled to mass spectrometry, information-driven computational docking, bio-layer interferometry, and site-directed mutagenesis was used to probe LbpB:hLf complexes. (ucalgary.ca)
Cells3
- These methods involve the use of genetically modified viruses to deliver the genetic material (11, 12), non-viral gene transfers including the direct physical introduction of the genetic material into cells (13-15) and formation of DNA complexes with inorganic salts, polycations, or lipids to transfer the DNA into the cells (16-18). (ualberta.ca)
- Because CPV has naturally high affinity to transferrin receptors (TfRs), which are often over-expressed on tumor cells, CPV might be used for specific targeting of tumour cells directly. (biomedcentral.com)
- Via the transferrin receptor, CPV-2 enters cells with a high division rate (Parker et al. (laboklin.com)
Binding3
- Gonococcal transferrin-binding protein 2 facilitates however just isn't essential for transferrin utilization. (wagergun.com)
- Binding of the trimeric TRAIL to its receptors TRAIL-R1 and TRAIL-R2 induces caspase activation and apoptosis [ 4 ], either through the extrinsic pathway alone or recruiting the intrinsic apoptotic pathway [ 5 ]. (biomedcentral.com)
- The Lf N-lobe is also capable of binding to negatively charged regions of the LbpB C-lobe and possibly other sites such that a variety of higher order complexes are formed. (ucalgary.ca)
Mechanisms1
- They have devised complex regulatory mechanisms responding to Fe 2+ unavailability that induce the expression of a series of genes to produce small iron chelators, termed siderophores [ 5 , 6 , 7 ], secrete them, and take up their iron-bound forms. (biomedcentral.com)
Structure1
- Circular Dichroism studies indicate that holo-transferrin maintains its secondary structure following modification, suggesting that the labelled protein could be transported via the transferrin receptor. (sfu.ca)
Human1
- Unlike cow milk, human milk contains lacto-N-biose (LNB), which is used as a substrate by bifidobacteria capable of using complex human milk oligosaccharides, such as B . infantis [ 6 ] . (encyclopedia.pub)
Active1
- The ligands of the compounds show promising cytotoxicity and selectivity, whereas the bimetallic complexes are less active, but still more cytotoxic than the parent Ru(III) complex. (sfu.ca)
Involves1
- The formation of a 1:1 complex of iron-loaded Lf and LbpB involves an interaction between the Lf C-lobe and LbpB N-lobe, comparable to TbpB, consistent with a potential role in iron acquisition. (ucalgary.ca)
Major1
- This graph shows the total number of publications written about "Receptors, Transferrin" by people in this website by year, and whether "Receptors, Transferrin" was a major or minor topic of these publications. (umassmed.edu)
Formation1
- Some strains produce a protein that confers resistance to complement by interfering with the formation of the membrane attack complex. (medscape.com)
Diverse1
- 5 gastric to clear contrast of gamma receptors, diverse nucleases and photovoltaic adipocytes( Shalaby et al. (erik-mill.de)
Components1
- Unlike liposomes, dendrimers, metal and semiconductor nanoparticles, the nanoparticles made of biopolymers, such as bacterial spores, viruses and alike are naturally uniform in size and offer precise control for the surface-displayed targeting groups and their components. (biomedcentral.com)
Role2
Activation1
- Tyagi R.K. Investigation into androgen-independent activation of androgen receptor in prostate cancer. (jnu.ac.in)
