Physicochemical property of fimbriated (FIMBRIAE, BACTERIAL) and non-fimbriated bacteria of attaching to cells, tissue, and nonbiological surfaces. It is a factor in bacterial colonization and pathogenicity.
Adherence of cells to surfaces or to other cells.
A property of the surface of an object that makes it stick to another surface.
Characteristics or attributes of the outer boundaries of objects, including molecules.
Surface ligands, usually glycoproteins, that mediate cell-to-cell adhesion. Their functions include the assembly and interconnection of various vertebrate systems, as well as maintenance of tissue integration, wound healing, morphogenic movements, cellular migrations, and metastasis.
Encrustations, formed from microbes (bacteria, algae, fungi, plankton, or protozoa) embedding in extracellular polymers, that adhere to surfaces such as teeth (DENTAL DEPOSITS); PROSTHESES AND IMPLANTS; and catheters. Biofilms are prevented from forming by treating surfaces with DENTIFRICES; DISINFECTANTS; ANTI-INFECTIVE AGENTS; and antifouling agents.
Polymers of silicone that are formed by crosslinking and treatment with amorphous silica to increase strength. They have properties similar to vulcanized natural rubber, in that they stretch under tension, retract rapidly, and fully recover to their original dimensions upon release. They are used in the encapsulation of surgical membranes and implants.
Cell-surface components or appendages of bacteria that facilitate adhesion (BACTERIAL ADHESION) to other cells or to inanimate surfaces. Most fimbriae (FIMBRIAE, BACTERIAL) of gram-negative bacteria function as adhesins, but in many cases it is a minor subunit protein at the tip of the fimbriae that is the actual adhesin. In gram-positive bacteria, a protein or polysaccharide surface layer serves as the specific adhesin. What is sometimes called polymeric adhesin (BIOFILMS) is distinct from protein adhesin.
A species of STAPHYLOCOCCUS that is a spherical, non-motile, gram-positive, chemoorganotrophic, facultative anaerobe. Mainly found on the skin and mucous membrane of warm-blooded animals, it can be primary pathogen or secondary invader.
Thin, hairlike appendages, 1 to 20 microns in length and often occurring in large numbers, present on the cells of gram-negative bacteria, particularly Enterobacteriaceae and Neisseria. Unlike flagella, they do not possess motility, but being protein (pilin) in nature, they possess antigenic and hemagglutinating properties. They are of medical importance because some fimbriae mediate the attachment of bacteria to cells via adhesins (ADHESINS, BACTERIAL). Bacterial fimbriae refer to common pili, to be distinguished from the preferred use of "pili", which is confined to sex pili (PILI, SEX).
Thin, filamentous protein structures, including proteinaceous capsular antigens (fimbrial antigens), that mediate adhesion of E. coli to surfaces and play a role in pathogenesis. They have a high affinity for various epithelial cells.
Pathological processes consisting of the union of the opposing surfaces of a wound.
A cell-surface ligand involved in leukocyte adhesion and inflammation. Its production is induced by gamma-interferon and it is required for neutrophil migration into inflamed tissue.
Proteins that are structural components of bacterial fimbriae (FIMBRIAE, BACTERIAL) or sex pili (PILI, SEX).
An anchoring junction of the cell to a non-cellular substrate. It is composed of a specialized area of the plasma membrane where bundles of the ACTIN CYTOSKELETON terminate and attach to the transmembrane linkers, INTEGRINS, which in turn attach through their extracellular domains to EXTRACELLULAR MATRIX PROTEINS.
Isomeric forms and derivatives of hexanol (C6H11OH).
Glycosides formed by the reaction of the hydroxyl group on the anomeric carbon atom of mannose with an alcohol to form an acetal. They include both alpha- and beta-mannosides.
Hard, amorphous, brittle, inorganic, usually transparent, polymerous silicate of basic oxides, usually potassium or sodium. It is used in the form of hard sheets, vessels, tubing, fibers, ceramics, beads, etc.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
A polyvinyl resin used extensively in the manufacture of plastics, including medical devices, tubing, and other packaging. It is also used as a rubber substitute.
Potentially pathogenic bacteria found in nasal membranes, skin, hair follicles, and perineum of warm-blooded animals. They may cause a wide range of infections and intoxications.
A broad family of synthetic organosiloxane polymers containing a repeating silicon-oxygen backbone with organic side groups attached via carbon-silicon bonds. Depending on their structure, they are classified as liquids, gels, and elastomers. (From Merck Index, 12th ed)
A species of gram-positive, coccoid bacteria commensal in the respiratory tract.
A type of scanning probe microscopy in which a probe systematically rides across the surface of a sample being scanned in a raster pattern. The vertical position is recorded as a spring attached to the probe rises and falls in response to peaks and valleys on the surface. These deflections produce a topographic map of the sample.
Cytokine-induced cell adhesion molecule present on activated endothelial cells, tissue macrophages, dendritic cells, bone marrow fibroblasts, myoblasts, and myotubes. It is important for the recruitment of leukocytes to sites of inflammation. (From Pigott & Power, The Adhesion Molecule FactsBook, 1993, p154)
Biocompatible materials usually used in dental and bone implants that enhance biologic fixation, thereby increasing the bond strength between the coated material and bone, and minimize possible biological effects that may result from the implant itself.
Synthetic or natural materials, other than DRUGS, that are used to replace or repair any body TISSUES or bodily function.
The aggregation of ERYTHROCYTES by AGGLUTININS, including antibodies, lectins, and viral proteins (HEMAGGLUTINATION, VIRAL).
A gram-positive organism found in dental plaque, in blood, on heart valves in subacute endocarditis, and infrequently in saliva and throat specimens. L-forms are associated with recurrent aphthous stomatitis.
Polymerized forms of styrene used as a biocompatible material, especially in dentistry. They are thermoplastic and are used as insulators, for injection molding and casting, as sheets, plates, rods, rigid forms and beads.
Polymeric materials (usually organic) of large molecular weight which can be shaped by flow. Plastic usually refers to the final product with fillers, plasticizers, pigments, and stabilizers included (versus the resin, the homogeneous polymeric starting material). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A dark-gray, metallic element of widespread distribution but occurring in small amounts; atomic number, 22; atomic weight, 47.90; symbol, Ti; specific gravity, 4.5; used for fixation of fractures. (Dorland, 28th ed)
Artificial substitutes for body parts, and materials inserted into tissue for functional, cosmetic, or therapeutic purposes. Prostheses can be functional, as in the case of artificial arms and legs, or cosmetic, as in the case of an artificial eye. Implants, all surgically inserted or grafted into the body, tend to be used therapeutically. IMPLANTS, EXPERIMENTAL is available for those used experimentally.
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
A non-receptor protein tyrosine kinase that is localized to FOCAL ADHESIONS and is a central component of integrin-mediated SIGNAL TRANSDUCTION PATHWAYS. Focal adhesion kinase 1 interacts with PAXILLIN and undergoes PHOSPHORYLATION in response to adhesion of cell surface integrins to the EXTRACELLULAR MATRIX. Phosphorylated p125FAK protein binds to a variety of SH2 DOMAIN and SH3 DOMAIN containing proteins and helps regulate CELL ADHESION and CELL MIGRATION.
Physiological processes and properties of BACTERIA.
A family of non-receptor, PROLINE-rich protein-tyrosine kinases.
Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY.
A species of gram-negative, aerobic, rod-shaped bacteria commonly isolated from clinical specimens (wound, burn, and urinary tract infections). It is also found widely distributed in soil and water. P. aeruginosa is a major agent of nosocomial infection.
Glycoproteins found on the surfaces of cells, particularly in fibrillar structures. The proteins are lost or reduced when these cells undergo viral or chemical transformation. They are highly susceptible to proteolysis and are substrates for activated blood coagulation factor VIII. The forms present in plasma are called cold-insoluble globulins.
A genus of gram-positive, coccoid bacteria whose organisms occur in pairs or chains. No endospores are produced. Many species exist as commensals or parasites on man or animals with some being highly pathogenic. A few species are saprophytes and occur in the natural environment.
Proteins found in any species of bacterium.
The adhesion of gases, liquids, or dissolved solids onto a surface. It includes adsorptive phenomena of bacteria and viruses onto surfaces as well. ABSORPTION into the substance may follow but not necessarily.
The testing of materials and devices, especially those used for PROSTHESES AND IMPLANTS; SUTURES; TISSUE ADHESIVES; etc., for hardness, strength, durability, safety, efficacy, and biocompatibility.
Established cell cultures that have the potential to propagate indefinitely.
Proteins isolated from the outer membrane of Gram-negative bacteria.
Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria found in soil, water, food, and clinical specimens. It is a prominent opportunistic pathogen for hospitalized patients.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Human colonic ADENOCARCINOMA cells that are able to express differentiation features characteristic of mature intestinal cells, such as ENTEROCYTES. These cells are valuable in vitro tools for studies related to intestinal cell function and differentiation.
A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors(RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation.
The thermodynamic interaction between a substance and WATER.
One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.
Substances that reduce the growth or reproduction of BACTERIA.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The interactions between a host and a pathogen, usually resulting in disease.
The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.
A light microscopic technique in which only a small spot is illuminated and observed at a time. An image is constructed through point-by-point scanning of the field in this manner. Light sources may be conventional or laser, and fluorescence or transmitted observations are possible.
Cell adhesion molecule involved in a diverse range of contact-mediated interactions among neurons, astrocytes, oligodendrocytes, and myotubes. It is widely but transiently expressed in many tissues early in embryogenesis. Four main isoforms exist, including CD56; (ANTIGENS, CD56); but there are many other variants resulting from alternative splicing and post-translational modifications. (From Pigott & Power, The Adhesion Molecule FactsBook, 1993, pp115-119)
A polysaccharide-producing species of STREPTOCOCCUS isolated from human dental plaque.
Materials which have structured components with at least one dimension in the range of 1 to 100 nanometers. These include NANOCOMPOSITES; NANOPARTICLES; NANOTUBES; and NANOWIRES.
The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.
Proteins obtained from ESCHERICHIA COLI.
A hexose or fermentable monosaccharide and isomer of glucose from manna, the ash Fraxinus ornus and related plants. (From Grant & Hackh's Chemical Dictionary, 5th ed & Random House Unabridged Dictionary, 2d ed)
Infections with bacteria of the species ESCHERICHIA COLI.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Surface ligands that mediate cell-to-cell adhesion and function in the assembly and interconnection of the vertebrate nervous system. These molecules promote cell adhesion via a homophilic mechanism. These are not to be confused with NEURAL CELL ADHESION MOLECULES, now known to be expressed in a variety of tissues and cell types in addition to nervous tissue.
Enumeration by direct count of viable, isolated bacterial, archaeal, or fungal CELLS or SPORES capable of growth on solid CULTURE MEDIA. The method is used routinely by environmental microbiologists for quantifying organisms in AIR; FOOD; and WATER; by clinicians for measuring patients' microbial load; and in antimicrobial drug testing.
Cell adhesion molecule and CD antigen that mediates neutrophil, monocyte, and memory T-cell adhesion to cytokine-activated endothelial cells. E-selectin recognizes sialylated carbohydrate groups related to the Lewis X or Lewis A family.
Paxillin is a signal transducing adaptor protein that localizes to FOCAL ADHESIONS via its four LIM domains. It undergoes PHOSPHORYLATION in response to integrin-mediated CELL ADHESION, and interacts with a variety of proteins including VINCULIN; FOCAL ADHESION KINASE; PROTO-ONCOGENE PROTEIN PP60(C-SRC); and PROTO-ONCOGENE PROTEIN C-CRK.
Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria.
Infections with bacteria of the genus STAPHYLOCOCCUS.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
Calcium-dependent cell adhesion proteins. They are important in the formation of ADHERENS JUNCTIONS between cells. Cadherins are classified by their distinct immunological and tissue specificities, either by letters (E- for epithelial, N- for neural, and P- for placental cadherins) or by numbers (cadherin-12 or N-cadherin 2 for brain-cadherin). Cadherins promote cell adhesion via a homophilic mechanism as in the construction of tissues and of the whole animal body.
Techniques used in studying bacteria.
Cell-surface glycoprotein beta-chains that are non-covalently linked to specific alpha-chains of the CD11 family of leukocyte-adhesion molecules (RECEPTORS, LEUKOCYTE-ADHESION). A defect in the gene encoding CD18 causes LEUKOCYTE-ADHESION DEFICIENCY SYNDROME.
The process whereby PLATELETS adhere to something other than platelets, e.g., COLLAGEN; BASEMENT MEMBRANE; MICROFIBRILS; or other "foreign" surfaces.
Those components of an organism that determine its capacity to cause disease but are not required for its viability per se. Two classes have been characterized: TOXINS, BIOLOGICAL and surface adhesion molecules that effect the ability of the microorganism to invade and colonize a host. (From Davis et al., Microbiology, 4th ed. p486)
Transport proteins that carry specific substances in the blood or across cell membranes.
Integrin beta-1 chains which are expressed as heterodimers that are noncovalently associated with specific alpha-chains of the CD49 family (CD49a-f). CD29 is expressed on resting and activated leukocytes and is a marker for all of the very late activation antigens on cells. (from: Barclay et al., The Leukocyte Antigen FactsBook, 1993, p164)
Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.
An integrin heterodimer widely expressed on cells of hematopoietic origin. CD11A ANTIGEN comprises the alpha chain and the CD18 antigen (ANTIGENS, CD18) the beta chain. Lymphocyte function-associated antigen-1 is a major receptor of T-CELLS; B-CELLS; and GRANULOCYTES. It mediates the leukocyte adhesion reactions underlying cytolytic conjugate formation, helper T-cell interactions, and antibody-dependent killing by NATURAL KILLER CELLS and granulocytes. Intracellular adhesion molecule-1 has been defined as a ligand for lymphocyte function-associated antigen-1.
Immunoglobulins produced in a response to BACTERIAL ANTIGENS.
A cytoskeletal protein associated with cell-cell and cell-matrix interactions. The amino acid sequence of human vinculin has been determined. The protein consists of 1066 amino acid residues and its gene has been assigned to chromosome 10.
The functional hereditary units of BACTERIA.
Integrin alpha4beta1 is a FIBRONECTIN and VCAM-1 receptor present on LYMPHOCYTES; MONOCYTES; EOSINOPHILS; NK CELLS and thymocytes. It is involved in both cell-cell and cell- EXTRACELLULAR MATRIX adhesion and plays a role in INFLAMMATION, hematopoietic cell homing and immune function, and has been implicated in skeletal MYOGENESIS; NEURAL CREST migration and proliferation, lymphocyte maturation and morphogenesis of the PLACENTA and HEART.
Cell adhesion molecule and CD antigen that mediates the adhesion of neutrophils and monocytes to activated platelets and endothelial cells.
The phenomenon by which dissociated cells intermixed in vitro tend to group themselves with cells of their own type.
A member of the immunoglobulin superfamily of neuronal cell adhesion molecules that is required for proper nervous system development. Neural cell adhesion molecule L1 consists of six Ig domains, five fibronectin domains, a transmembrane region and an intracellular domain. Two splicing variants are known: a neuronal form that contains a four-amino acid RSLE sequence in the cytoplasmic domain, and a non-neuronal form that lacks the RSLE sequence. Mutations in the L1 gene result in L1 disease. Neural cell adhesion molecule L1 is predominantly expressed during development in neurons and Schwann cells; involved in cell adhesion, neuronal migration, axonal growth and pathfinding, and myelination.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
A non-receptor protein-tyrosine kinase that is expressed primarily in the BRAIN; OSTEOBLASTS; and LYMPHOID CELLS. In the CENTRAL NERVOUS SYSTEM focal adhesion kinase 2 modulates ION CHANNEL function and MITOGEN-ACTIVATED PROTEIN KINASES activity.
A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere.
White blood cells. These include granular leukocytes (BASOPHILS; EOSINOPHILS; and NEUTROPHILS) as well as non-granular leukocytes (LYMPHOCYTES and MONOCYTES).
The network of filaments, tubules, and interconnecting filamentous bridges which give shape, structure, and organization to the cytoplasm.
Major constituent of the cytoskeleton found in the cytoplasm of eukaryotic cells. They form a flexible framework for the cell, provide attachment points for organelles and formed bodies, and make communication between parts of the cell possible.
Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.
Filamentous proteins that are the main constituent of the thin filaments of muscle fibers. The filaments (known also as filamentous or F-actin) can be dissociated into their globular subunits; each subunit is composed of a single polypeptide 375 amino acids long. This is known as globular or G-actin. In conjunction with MYOSINS, actin is responsible for the contraction and relaxation of muscle.
Pathological processes involving the PERITONEUM.
Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.
Antibodies produced by a single clone of cells.
Specialized areas at the CELL MEMBRANE where a cell attaches to the EXTRACELLULAR MATRIX or other substratum.
A family of membrane glycoproteins localized to TIGHT JUNCTIONS that contain two extracellular Ig-like domains, a single transmembrane segment, and a cytoplasmic tail of variable length.
Cell surface glycoproteins on lymphocytes and other leukocytes that mediate adhesion to specialized blood vessels called high endothelial venules. Several different classes of lymphocyte homing receptors have been identified, and they appear to target different surface molecules (addressins) on high endothelial venules in different tissues. The adhesion plays a crucial role in the trafficking of lymphocytes.
Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.
Large, noncollagenous glycoprotein with antigenic properties. It is localized in the basement membrane lamina lucida and functions to bind epithelial cells to the basement membrane. Evidence suggests that the protein plays a role in tumor invasion.
Venous vessels in the umbilical cord. They carry oxygenated, nutrient-rich blood from the mother to the FETUS via the PLACENTA. In humans, there is normally one umbilical vein.

Role of antibodies against Bordetella pertussis virulence factors in adherence of Bordetella pertussis and Bordetella parapertussis to human bronchial epithelial cells. (1/5458)

Immunization with whole-cell pertussis vaccines (WCV) containing heat-killed Bordetella pertussis cells and with acellular vaccines containing genetically or chemically detoxified pertussis toxin (PT) in combination with filamentous hemagglutinin (FHA), pertactin (Prn), or fimbriae confers protection in humans and animals against B. pertussis infection. In an earlier study we demonstrated that FHA is involved in the adherence of these bacteria to human bronchial epithelial cells. In the present study we investigated whether mouse antibodies directed against B. pertussis FHA, PTg, Prn, and fimbriae, or against two other surface molecules, lipopolysaccharide (LPS) and the 40-kDa outer membrane porin protein (OMP), that are not involved in bacterial adherence, were able to block adherence of B. pertussis and B. parapertussis to human bronchial epithelial cells. All antibodies studied inhibited the adherence of B. pertussis to these epithelial cells and were equally effective in this respect. Only antibodies against LPS and 40-kDa OMP affected the adherence of B. parapertussis to epithelial cells. We conclude that antibodies which recognize surface structures on B. pertussis or on B. parapertussis can inhibit adherence of the bacteria to bronchial epithelial cells, irrespective whether these structures play a role in adherence of the bacteria to these cells.  (+info)

Role of Bordetella pertussis virulence factors in adherence to epithelial cell lines derived from the human respiratory tract. (2/5458)

During colonization of the respiratory tract by Bordetella pertussis, virulence factors contribute to adherence of the bacterium to the respiratory tract epithelium. In the present study, we examined the roles of the virulence factors filamentous hemagglutinin (FHA), fimbriae, pertactin (Prn), and pertussis toxin (PT) in the adherence of B. pertussis to cells of the human bronchial epithelial cell line NCI-H292 and of the laryngeal epithelial cell line HEp-2. Using B. pertussis mutant strains and purified FHA, fimbriae, Prn, and PT, we demonstrated that both fimbriae and FHA are involved in the adhesion of B. pertussis to laryngeal epithelial cells, whereas only FHA is involved in the adherence to bronchial epithelial cells. For PT and Prn, no role as adhesion factor was found. However, purified PT bound to both bronchial and laryngeal cells and as such reduced the adherence of B. pertussis to these cells. These data may imply that fimbriae play a role in infection of only the laryngeal mucosa, while FHA is the major factor in colonization of the entire respiratory tract.  (+info)

Enhanced adhesion of Pasteurella multocida to cultured turkey peripheral blood monocytes. (3/5458)

Capsular hyaluronic acid (HA) mediates adhesion of serogroup A strains of Pasteurella multocida to elicited turkey air sac macrophages (TASM). In contrast, freshly isolated turkey peripheral blood monocytes (TPBM) do not bind serogroup A strains. Following culture of TPBM for 6 days in chamber slides, adhesion of the bacteria to TPBM increased gradually. Incubation in chamber slides coated with entactin-collagen IV-laminin (ECL) attachment matrix or exposure to phorbol myristate acetate (PMA) further enhanced the adhesion of P. multocida to TPBM. Addition of HA, but not Arg-Gly-Asp peptide, to TPBM culture inhibited bacterial adherence similarly to the inhibition previously reported for TASM. Exposure of TPBM to monoclonal antibody directed against HA-binding cell surface proteoglycan (CD44) decreased binding of P. multocida. Collectively, these findings indicate that P. multocida adhesion to TPBM is mediated by capsular HA and can be increased by culture on ECL attachment matrix or PMA exposure. Additionally, the findings suggest that the capsular mucopolysaccharide of serogroup A strains of P. multocida recognizes an isoform of CD44 expressed on cultured TPBM.  (+info)

Genetic characterization of a new type IV-A pilus gene cluster found in both classical and El Tor biotypes of Vibrio cholerae. (4/5458)

The Vibrio cholerae genome contains a 5.4-kb pil gene cluster that resembles the Aeromonas hydrophila tap gene cluster and other type IV-A pilus assembly operons. The region consists of five complete open reading frames designated pilABCD and yacE, based on the nomenclature of related genes from Pseudomonas aeruginosa and Escherichia coli K-12. This cluster is present in both classical and El Tor biotypes, and the pilA and pilD genes are 100% conserved. The pilA gene encodes a putative type IV pilus subunit. However, deletion of pilA had no effect on either colonization of infant mice or adherence to HEp-2 cells, demonstrating that pilA does not encode the primary subunit of a pilus essential for these processes. The pilD gene product is similar to other type IV prepilin peptidases, proteins that process type IV signal sequences. Mutational analysis of the pilD gene showed that pilD is essential for secretion of cholera toxin and hemagglutinin-protease, mannose-sensitive hemagglutination (MSHA), production of toxin-coregulated pili, and colonization of infant mice. Defects in these functions are likely due to the lack of processing of N termini of four Eps secretion proteins, four proteins of the MSHA cluster, and TcpB, all of which contain type IV-A leader sequences. Some pilD mutants also showed reduced adherence to HEp-2 cells, but this defect could not be complemented in trans, indicating that the defect may not be directly due to a loss of pilD. Taken together, these data demonstrate the effectiveness of the V. cholerae genome project for rapid identification and characterization of potential virulence factors.  (+info)

Molecular basis for the enterocyte tropism exhibited by Salmonella typhimurium type 1 fimbriae. (5/5458)

Salmonella typhimurium exhibits a distinct tropism for mouse enterocytes that is linked to their expression of type 1 fimbriae. The distinct binding traits of Salmonella type 1 fimbriae is also reflected in their binding to selected mannosylated proteins and in their ability to promote secondary bacterial aggregation on enterocyte surfaces. The determinant of binding in Salmonella type 1 fimbriae is a 35-kDa structurally distinct fimbrial subunit, FimHS, because inactivation of fimHS abolished binding activity in the resulting mutant without any apparent effect on fimbrial expression. Surprisingly, when expressed in the absence of other fimbrial components and as a translational fusion protein with MalE, FimHS failed to demonstrate any specific binding tropism and bound equally to all cells and mannosylated proteins tested. To determine if the binding specificity of Salmonella type 1 fimbriae was determined by the fimbrial shaft that is intimately associated with FimHS, we replaced the amino-terminal half of FimHS with the corresponding sequence from Escherichia coli FimH (FimHE) that contains the receptor binding domain of FimHE. The resulting hybrid fimbriae bearing FimHES on a Salmonella fimbrial shaft exhibited binding traits that resembled that of Salmonella rather than E. coli fimbriae. Apparently, the quaternary constraints imposed by the fimbrial shaft on the adhesin determine the distinct binding traits of S. typhimurium type 1 fimbriae.  (+info)

P fimbriae and other adhesins enhance intestinal persistence of Escherichia coli in early infancy. (6/5458)

Resident and transient Escherichia coli strains were identified in the rectal flora of 22 Pakistani infants followed from birth to 6 months of age. All strains were tested for O-antigen expression, adhesin specificity (P fimbriae, other mannose-resistant adhesins or type 1 fimbriae) and adherence to the colonic cell line HT-29. Resident strains displayed higher mannose-resistant adherence to HT-29 cells, and expressed P fimbriae (P = 0.0036) as well as other mannose-resistant adhesins (P = 0.012) more often than transient strains. In strains acquired during the first month of life, P fimbriae were 12 times more frequent in resident than in transient strains (P = 0.0006). The O-antigen distribution did not differ between resident and transient strains, and none of the resident P-fimbriated strains belonged to previously recognized uropathogenic clones. The results suggest that adhesins mediating adherence to intestinal epithelial cells, especially P fimbriae, enhance the persistence of E. coli in the large intestine of infants.  (+info)

Roles of Pseudomonas aeruginosa las and rhl quorum-sensing systems in control of twitching motility. (7/5458)

Pseudomonas aeruginosa is a ubiquitous environmental bacterium and an important human pathogen. The production of several virulence factors by P. aeruginosa is controlled through two quorum-sensing systems, las and rhl. We have obtained evidence that both the las and rhl quorum-sensing systems are also required for type 4 pilus-dependent twitching motility and infection by the pilus-specific phage D3112cts. Mutants which lack the ability to synthesize PAI-1, PAI-2, or both autoinducers were significantly or greatly impaired in twitching motility and in susceptibility to D3112cts. Twitching motility and phage susceptibility in the autoinducer-deficient mutants were partially restored by exposure to exogenous PAI-1 and PAI-2. Both twitching motility and infection by pilus-specific phage are believed to be dependent on the extension and retraction of polar type 4 pili. Western blot analysis of whole-cell lysates and enzyme-linked immunosorbent assays of intact cells were used to measure the amounts of pilin on the cell surfaces of las and rhl mutants relative to that of the wild type. It appears that PAI-2 plays a crucial role in twitching motility and phage infection by affecting the export and assembly of surface type 4 pili. The ability of P. aeruginosa cells to adhere to human bronchial epithelial cells was also found to be dependent on the rhl quorum-sensing system. Microscopic analysis of twitching motility indicated that mutants which were unable to synthesize PAI-1 were defective in the maintenance of cellular monolayers and migrating packs of cells. Thus, PAI-1 appears to have an essential role in maintaining cell-cell spacing and associations required for effective twitching motility.  (+info)

Cell surface-associated lipoteichoic acid acts as an adhesion factor for attachment of Lactobacillus johnsonii La1 to human enterocyte-like Caco-2 cells. (8/5458)

The influence of pH on the adhesion of two Lactobacillus strains to Caco-2 human intestinal cells was investigated. One strain, Lactobacillus johnsonii La1, was adherent at any pH between 4 and 7. The other one, L. acidophilus La10, did not attach to this cell line under the same experimental conditions. On the basis of these results, we used the monoclonal antibody technique as a tool to determine differences on the surface of these bacteria and to identify a factor for adhesion. Mice were immunized with live La1, and the hybridomas produced by fusion of spleen cells with ONS1 cells were screened for the production of antibodies specific for L. johnsonii La1. A set of these monoclonal antibodies was directed against a nonproteinaceous component of the L. johnsonii La1 surface. It was identified as lipoteichoic acid (LTA). This molecule was isolated, chemically characterized, and tested in adhesion experiments in the same system. The adhesion of L. johnsonii La1 to Caco-2 cells was inhibited in a concentration-dependent way by purified LTA as well as by L. johnsonii La1 culture supernatant that contained LTA. These results showed that the mechanism of adhesion of L. johnsonii La1 to human Caco-2 cells involves LTA.  (+info)

Examples of how 'Tissue Adhesions' is used in the medical field:

1. In gastrointestinal surgery, tissue adhesions can form between the intestines and other organs, leading to bowel obstruction, inflammation, or other complications.
2. In cardiovascular surgery, tissue adhesions can form between the heart and surrounding tissues, causing impaired heart function and increasing the risk of postoperative complications.
3. In gynecological surgery, tissue adhesions can form between the uterus and other pelvic organs, leading to pain, bleeding, and infertility.
4. In oncologic surgery, tissue adhesions can form between cancerous tissues and surrounding normal tissues, making it difficult to remove the tumor completely.
5. In chronic diseases such as endometriosis, tissue adhesions can form between the uterus and other pelvic structures, leading to pain and infertility.
6. Tissue adhesions can also form within the skin, causing keloids or other types of scarring.

Treatment options for tissue adhesions depend on the location, size, and severity of the adhesions, as well as the underlying cause. Some common treatment options include:

1. Surgical removal of adhesions: This involves surgically removing the fibrous bands or scar tissue that are causing the adhesions.
2. Steroid injections: Injecting steroids into the affected area can help reduce inflammation and shrink the adhesions.
3. Physical therapy: Gentle stretching and exercise can help improve range of motion and reduce stiffness in the affected area.
4. Radiofrequency ablation: This is a minimally invasive procedure that uses heat to break down and remove the fibrous bands causing the adhesions.
5. Laser therapy: Laser therapy can be used to break down and remove the fibrous bands causing the adhesions, or to reduce inflammation and promote healing.
6. Natural remedies: Some natural remedies such as turmeric, ginger, and omega-3 fatty acids have anti-inflammatory properties and may help reduce inflammation and improve symptoms.

Preventing tissue adhesions is not always possible, but there are some measures that can be taken to reduce the risk of their formation. These include:

1. Proper wound care: Keeping wounds clean and dry, and using sterile dressings can help prevent infection and reduce the risk of adhesion formation.
2. Minimizing trauma: Avoiding unnecessary trauma to the affected area can help reduce the risk of adhesion formation.
3. Gentle exercise: Gentle exercise and stretching after surgery or injury can help improve range of motion and reduce stiffness in the affected area.
4. Early mobilization: Early mobilization after surgery or injury can help reduce the risk of adhesion formation.
5. Avoiding smoking: Smoking can impede wound healing and increase the risk of adhesion formation, so avoiding smoking is recommended.
6. Using anti-adhesive agents: Applying anti-adhesive agents such as silicone or hydrogel to the affected area after surgery or injury can help reduce the risk of adhesion formation.

It's important to note that the most effective method for preventing or treating tissue adhesions will depend on the specific cause and location of the adhesions, as well as the individual patient's needs and medical history. A healthcare professional should be consulted for proper evaluation and treatment.

Here are some common types of E. coli infections:

1. Urinary tract infections (UTIs): E. coli is a leading cause of UTIs, which occur when bacteria enter the urinary tract and cause inflammation. Symptoms include frequent urination, burning during urination, and cloudy or strong-smelling urine.
2. Diarrheal infections: E. coli can cause diarrhea, abdominal cramps, and fever if consumed through contaminated food or water. In severe cases, this type of infection can lead to dehydration and even death, particularly in young children and the elderly.
3. Septicemia (bloodstream infections): If E. coli bacteria enter the bloodstream, they can cause septicemia, a life-threatening condition that requires immediate medical attention. Symptoms include fever, chills, rapid heart rate, and low blood pressure.
4. Meningitis: In rare cases, E. coli infections can spread to the meninges, the protective membranes covering the brain and spinal cord, causing meningitis. This is a serious condition that requires prompt treatment with antibiotics and supportive care.
5. Hemolytic-uremic syndrome (HUS): E. coli infections can sometimes cause HUS, a condition where the bacteria destroy red blood cells, leading to anemia, kidney failure, and other complications. HUS is most common in young children and can be fatal if not treated promptly.

Preventing E. coli infections primarily involves practicing good hygiene, such as washing hands regularly, especially after using the bathroom or before handling food. It's also essential to cook meat thoroughly, especially ground beef, to avoid cross-contamination with other foods. Avoiding unpasteurized dairy products and drinking contaminated water can also help prevent E. coli infections.

If you suspect an E. coli infection, seek medical attention immediately. Your healthcare provider may perform a urine test or a stool culture to confirm the diagnosis and determine the appropriate treatment. In mild cases, symptoms may resolve on their own within a few days, but antibiotics may be necessary for more severe infections. It's essential to stay hydrated and follow your healthcare provider's recommendations to ensure a full recovery.

Staphylococcal infections can be classified into two categories:

1. Methicillin-Resistant Staphylococcus Aureus (MRSA) - This type of infection is resistant to many antibiotics and can cause severe skin infections, pneumonia, bloodstream infections and surgical site infections.

2. Methicillin-Sensitive Staphylococcus Aureus (MSSA) - This type of infection is not resistant to antibiotics and can cause milder skin infections, respiratory tract infections, sinusitis and food poisoning.

Staphylococcal infections are caused by the Staphylococcus bacteria which can enter the body through various means such as:

1. Skin cuts or open wounds
2. Respiratory tract infections
3. Contaminated food and water
4. Healthcare-associated infections
5. Surgical site infections

Symptoms of Staphylococcal infections may vary depending on the type of infection and severity, but they can include:

1. Skin redness and swelling
2. Increased pain or tenderness
3. Warmth or redness in the affected area
4. Pus or discharge
5. Fever and chills
6. Swollen lymph nodes
7. Shortness of breath

Diagnosis of Staphylococcal infections is based on physical examination, medical history, laboratory tests such as blood cultures, and imaging studies such as X-rays or CT scans.

Treatment of Staphylococcal infections depends on the type of infection and severity, but may include:

1. Antibiotics to fight the infection
2. Drainage of abscesses or pus collection
3. Wound care and debridement
4. Supportive care such as intravenous fluids, oxygen therapy, and pain management
5. Surgical intervention in severe cases.

Preventive measures for Staphylococcal infections include:

1. Good hand hygiene practices
2. Proper cleaning and disinfection of surfaces and equipment
3. Avoiding close contact with people who have Staphylococcal infections
4. Covering wounds and open sores
5. Proper sterilization and disinfection of medical equipment.

It is important to note that MRSA (methicillin-resistant Staphylococcus aureus) is a type of Staphylococcal infection that is resistant to many antibiotics, and can be difficult to treat. Therefore, early diagnosis and aggressive treatment are crucial to prevent complications and improve outcomes.

Some common types of peritoneal diseases include:

1. Peritonitis: This is an inflammation of the peritoneum, often caused by bacterial or viral infections.
2. Ascites: This is the accumulation of fluid in the abdominal cavity, which can be caused by a variety of factors, including liver disease, kidney failure, and cancer.
3. Peritoneal mesothelioma: This is a type of cancer that affects the peritoneum, often causing abdominal pain, bowel obstruction, and weight loss.
4. Omental torsion: This is a rare condition in which the omentum (a fold of peritoneum that covers the intestines) becomes twisted, cutting off blood supply to the intestines.
5. Peritoneal coccidiosis: This is an infection caused by the parasite Isospora belli, which can cause diarrhea, weight loss, and other gastrointestinal symptoms.

Peritoneal diseases can be diagnosed through a variety of tests, including abdominal imaging, blood tests, and biopsies. Treatment options vary depending on the specific type of disease and its severity, but may include antibiotics, surgery, or chemotherapy.

Bacterial adhesion involves the attachment (or deposition) of bacteria on the surface (solid, gel layer, etc.). This ... Jeremy A. Redman, Sharon L. Walker and Menachem Elimelech, Bacterial adhesion and transport in porous media: role of the ... The motility of bacteria also has a significant effect on the bacterial adhesion. Nonmotile and motile bacteria showed ... system has currently been used for the experiment of bacterial adhesion with the verification of DLVO theory. It is a well- ...
Prokaryotes have adhesion molecules on their cell surface termed bacterial adhesins, apart from using its pili (fimbriae) and ... Anti-adhesion therapy can be used to prevent infection by targeting adhesion molecules either on the pathogen or on the host ... Pizarro-Cerdá, Javier; Cossart, Pascale (2006). "Bacterial Adhesion and Entry into Host Cells". Cell. 124 (4): 715-727. doi: ... Ofek, Itzhak; Hasty, David L; Sharon, Nathan (2003). "Anti-adhesion therapy of bacterial diseases: prospects and problems". ...
Islam, Salim T.; Mignot, Tâm (2015). "The mysterious nature of bacterial surface (Gliding) motility: A focal adhesion-based ... Bacterial swimming is used in bacterial taxis (mediated by specific receptors and signal transduction pathways) for the ... A bacterial biofilm is a bacterial community attached into a surface through extracellular polymeric materials. Prior to ... Dozens of these structures can exist on the bacterial and archaeal surface. Twitching motility is a form of crawling bacterial ...
... mucin adhesion blocks bacterial adhesion on surfaces. Consequently, the risk of bacterial attachment and infection is reduced. ... Due to the adsorption of BSM, the hydrophobicity of the surface decreases as well as the incidence of bacterial adhesion. Drug ... Just like the application above, the PAA polymer improved the adsorption of BSM on its surface to prevent bacterial adhesion ... While bacterial infections are common concerns in the medical, dental, and food industries, they are the primary cause of ...
Bacterial adhesion force quantification by fluidic force microscopy. (2015) Nanoscale, 7 (9), 4070 - 4079. doi:10.1039/ ... By measuring the adhesion of single cells, important information for different topics in biology and materialscience can be ... With FluidFM it is possible to increase the rate in which these experiments can be performed, and even to assess the adhesion ... By raising the probe, the force of the adhesion can be measured with pN resolution. The method to perform a single bacteria ...
Bacterial adhesion is particularly important for oral bacteria. Oral bacteria have evolved mechanisms to sense their ... However, a highly efficient innate host defense system constantly monitors the bacterial colonization and prevents bacterial ... In equilibrium, the bacterial biofilm produced by the fermentation of sugar in the mouth is quickly swept away by the saliva, ... Most of the bacterial species found in the mouth belong to microbial communities, called biofilms, a feature of which is inter- ...
Besides bacterial adhesion and cleaning, micro and nano pollutants (biological and manmade) is an area of contact lens research ... "Bacterial Adhesion to Worn Silicone Hydrogel Contact Lenses". Optometry and Vision Science. 85 (7): 520-525. doi:10.1097/OPX. ... "Bacterial adhesion to conventional hydrogel and new silicone hydrogel contact lens materials". Graefes Arch Clin Exp Ophthalmol ... Bacterial keratitis and conjunctivitis. In: Smolin G, Thoft RA, editors. The Cornea. Scientific Foundations and Clinical ...
Mignot, T.; Shaevitz, J.; Hartzell, P.; Zusman, D. (2007). "Evidence that focal adhesion complexes power bacterial gliding ... Bacterial gliding is a type of gliding motility that can also use pili for propulsion. The speed of gliding varies between ... "Focal adhesion complexes" and "treadmilling" of surface adhesins distributed along the cell body. The gliding motility of ... In the diagram above, right: Bacterial gliding is a process of motility whereby a bacterium can move under its own power. ...
Thanassi DG (2011). "The long and the short of bacterial adhesion regulation". J Bacteriol. 193 (2): 327-8. doi:10.1128/JB. ... Essentially, the main function of the YadA domain is to help cell adhesion and to increase virulence. YadA is a collagen- ... YadA is an example of an oligomeric coiled-coil adhesion (Oca). The Oca protein families are a subset of autotransporters, also ... The function is to promote their pathogenicity and virulence in host cells, though cell adhesion. YadA is found in three ...
"Evidence That Focal Adhesion Complexes Power Bacterial Gliding Motility". Science. 315 (5813): 853-856. Bibcode:2007Sci...315.. ... "Evidence that focal adhesion complexes power bacterial gliding motility". Science. 315 (5813): 853-856. Bibcode:2007Sci...315.. ... The adhesion proteins are assembled at the leading pole of the cell, and disassembled at the trailing end of the cell. The ... The adhesion proteins may allow the cell to move across the substrate, while the slime propulsion system aids in lubrication. ...
"Evidence that focal adhesion complexes power bacterial gliding motility". Science. 315 (5813): 853-856. Bibcode:2007Sci...315.. ... He is known for his work in single-molecule biophysics, bacterial growth and motility, and animal behavior. Shaevitz completed ... His group also studies bacterial cell mechanics, including bending rigidity, turgor pressure and cell wall stiffness, and ... "The bacterial actin MreB rotates, and rotation depends on cell-wall assembly". Proceedings of the National Academy of Sciences ...
Fasciclin I is an insect neural cell adhesion molecule involved in axonal guidance that is attached to the membrane by a GPI- ... Bacterial immunogenic protein MPT70 (1 FAS1 domain). The FAS1 domains of both human periostin and BIgH3 proteins were found to ... Kim JE, Kim SJ, Lee BH, Park RW, Kim KS, Kim IS (October 2000). "Identification of motifs for cell adhesion within the repeated ... Fasciclin 2 Huber O, Sumper M (September 1994). "Algal-CAMs: isoforms of a cell adhesion molecule in embryos of the alga Volvox ...
These glycoproteins include proline-rich proteins that allow bacterial adhesion. Pellicle somewhat protects enamel, but not ... The surface of enamel and dentin attracts salivary glycoproteins and bacterial products creating the pellicle layer. This thin ...
The bacterial adhesion reduction is reached by Met I ad concentration similar to the plasmatic peak obtained after a single 300 ... Antiadhesive activity Erdosteine is able to interfere with bacterial adhesion. In fact, Met I can affect the integrity of the ... Erdosteine showed in vivo and in vitro synergistic activity with antibiotics, against bacterial adhesiveness, in patients with ... the opening of this bond can induce a morphological change that interferes with the binding of bacterial adhesin (fimbriae) to ...
Because of their antimicrobial activity, thiolated polymers are also used as coatings that avoid bacterial adhesion. Thiomers ... "N-acetylcysteine-functionalized coating avoids bacterial adhesion and biofilm formation". Sci. Rep. 7 (1): 17374. Bibcode: ... Interaction with a bacterial membrane model". React. Funct. Polym. 73 (10): 1384-1390. doi:10.1016/j.reactfunctpolym.2013.01. ...
"A-type cranberry proanthocyanidins and uropathogenic bacterial anti-adhesion activity". Phytochemistry. 66 (18): 2281-91. doi: ... In vitro, A-type proanthocyanidins isolated from cranberry juice cocktail demonstrated anti-adhesion activity against E. coli ... and reduction of the risk of urinary tract infection by inhibiting the adhesion of certain bacteria in the urinary tract ...
1994). "CD66 identifies the biliary glycoprotein (BGP) adhesion molecule: cloning, expression, and adhesion functions of the ... The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. ... Carcinoembryonic antigen-related cell adhesion molecule 3 (CEACAM3) also known as CD66d (Cluster of Differentiation 66d), is a ... "Entrez Gene: CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3". CEACAM3: an innate immune receptor directed ...
In the next 24 hours, this layer allows the process of bacterial adhesion to occur, with both diatoms and bacteria (e.g. Vibrio ... 2001), "Hydrophobicity in Bacterial Adhesion", Biofilm community interactions: chance or necessity? (PDF), BioLine, ISBN 978- ... Biofouling is divided into microfouling-biofilm formation and bacterial adhesion-and macrofouling-attachment of larger ... demonstrate a high correlation between their resistance to bacterial adhesion and their hydrophobicity. A study of the ...
This is possible due to the bacterial protein FimH, which mediates high adhesion in response to high flow. The lectin domain is ... Catch bonds also play a significant role in bacterial adhesion, most notably in Escherichia coli. E. coli and other bacteria ... Thomas WE, Trintchina E, Forero M, Vogel V, Sokurenko EV (June 2002). "Bacterial adhesion to target cells enhanced by shear ... Isberg RR, Barnes P (July 2003). "Dancing with the host: Flow-dependent bacterial adhesion". Cell. 110 (1): 1-4. doi:10.1016/ ...
The classic descriptions of LAD included recurrent bacterial infections, defects in neutrophil adhesion, and a delay in ... Leukocyte adhesion cascade Congenital disorder of glycosylation "Leukocyte Adhesion Deficiency: Immunodeficiency Disorders: ... Types of leukocyte adhesion deficiency include LAD1, LAD2, and LAD3. LAD1 is the most common. Patients with LAD1 have an ... The adhesion defects result in poor leukocyte chemotaxis, particularly neutrophil, inability to form pus and neutrophilia. ...
YadA bacterial adhesin protein domain Type V secretion system Virulence factor Cell adhesion Outer membrane Gram negative ... they are a complex that aids adhesion to the ECM. Secretion is one method of transferring substances across the bacterial outer ... Bacteria use TAAs in order to infect their host cells via a process called cell adhesion. TAAs also go by another name, ... Function: Their role is to act as spacers by moving the head domains away from the bacterial cell surface and toward the ...
Simulation of bacterial attraction and adhesion to falling particles in an aquatic environment. Limnol. Oceanogr. 34: 514-530. ... In 2003, a new bacterial species was discovered that swim sideways and respond to differences in oxygen concentration at the ... The gradient-sensing mechanism in bacterial chemotaxis. Proc. Natl. Acad. Sci. U.S.A. 69: 2509 -2512. Adler, J. 1975. ... Mathematical modeling and quantitative characterization of bacterial motility and chemotaxis. In Modeling the Metabolic and ...
... and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a ...
Critical for Reducing Bacterial Adhesion". Langmuir. 19 (17): 6912-6921. doi:10.1021/la034032m. ISSN 0743-7463. Vogel, Birte ... From 2006 until 2007, Gram participated in the Galathea 3 expeditions, and she is using the bacterial cultures initiated during ... Gram's research extends to investigations of the global distribution of bacterial species, and an examination of how the ... Lone Gram is Danish microbiologist known for her work in bacterial physiology, microbial communication, and biochemicals that ...
Studies are under way to characterize the bacterial isolates from the outbreak in detail. Physicians around the world should be ... The bacteria contain an adhesion protein for the carbohydrate sequence Gal-1,4Gal. After incubation with various amounts of the ... Detection of the zoonotic bacterial pathogen Streptococcus suis was achieved using magnetic glycoparticles. ... the Bacterial Diversity Metadatabase Portal: Biology (CS1 maint: multiple names: authors list, Articles with short description ...
Lpp induces adhesion of neutrophils to human endothelial cells by activating the latter. Seltmann, Guntram; Holst, Otto (2002 ... Silhavy TJ, Kahne D, Walker S (2010). "The bacterial cell envelope". Cold Spring Harbor Perspectives in Biology. 2 (5): a000414 ... Kovacs-Simon A, Titball RW, Michell SL (2011). "Lipoproteins of bacterial pathogens". Infection and Immunity. 79 (2): 548-61. ... The Bacterial Cell Wall. Berlin: Springer. pp. 81-82. ISBN 3-540-42608-6. Dramsi S, Magnet S, Davison S, Arthur M (2008). " ...
These surface/adhesion proteins mediate the initial attachment of bacteria to host tissues. These proteins are covalently ... Sortases are membrane anchored enzyme that sort these surface proteins onto the bacterial cell surface and anchor them to the ... inhibition of sortases may offer a novel strategy against gram-positive bacterial infections. SrtB in particular has gained ... linked to the peptidoglycan of the bacterial cell wall. As more and more pathogens become resistant to antibiotics, ...
Adhesin molecule (immunoglobulin -like) Bacterial adhesin Cell adhesion de Groot, Piet W. J.; Bader, Oliver; de Boer, Albert D ... Adhesion to tissue is an obligatory first step in pathogenesis by many yeasts. Adhesins also have other functions, such as ...
These vesicles were suspected to promote bacterial adhesion to the host epithelial cell surface. Their role in invasion of ... In prokaryotic, gram-negative bacterial cells, membrane vesicle trafficking is mediated through bacterial outer membrane ... In inter-bacterial interactions, OMVs released by Pseudomonas aeruginosa microbes were shown to fuse with outer membrane of ... Bacterial membrane vesicles dispersion along the cell surface was measured in live Escherichia coli, commensal bacteria common ...
Bacterial adhesion to boat hulls serves as the foundation for biofouling of seagoing vessels. Once a film of bacteria forms, it ... Bacterial autolysis is a key mechanism in biofilm structural regulation, providing an abundant source of competent DNA primed ... "Building Codes for Bacterial Cities , Quanta Magazine". Quanta Magazine. Retrieved 25 July 2017. Lear G, Lewis GD, eds. (2012 ... Bacterial biofilms start the colonization process by creating microenvironments that are more favorable for biofouling species ...
Bacterial metabolic networks are a striking example of bow-tie organization, an architecture able to input a wide range of ... Proteins are also important in cell signaling, immune responses, cell adhesion, active transport across membranes, and the cell ... Michie KA, Löwe J (2006). "Dynamic filaments of the bacterial cytoskeleton". Annual Review of Biochemistry. 75: 467-92. doi: ... Gupta R, Gupta N, Rathi P (June 2004). "Bacterial lipases: an overview of production, purification and biochemical properties ...
v t e (Bacterial proteins, Whooping cough, Virulence factors, All stub articles, Protein stubs). ... a multifaceted adhesion produced by virulent Bordetella spp". Molecular Microbiology. 9: 653-60. doi:10.1111/j.1365-2958.1993. ...
Studies have suggested that rOmpB is involved in this process of adhesion and invasion. Both rOmpA and rOmpB are members of a ... Rocky Mountain spotted fever (RMSF) is a bacterial disease spread by ticks. It typically begins with a fever and headache, ... Bacterial replication in host cells causes endothelial cell proliferation and inflammation, resulting in mononuclear cell ... Mediates Bacterial Invasion through Ku70 in an Actin, c-Cbl, Clathrin and Caveolin 2-Dependent Manner". Cellular Microbiology. ...
These bacterial pathogens cause a thinning of cervical mucus and allow bacteria from the vagina into the uterus and fallopian ... Laparoscopy for lysis of adhesions may be performed for refractory pain.[citation needed] Peter, N. G.; Clark, L. R.; Jaeger, J ... Curtis, Arthur H. (1930). "A cause of adhesions in the right upper quadrant". JAMA. 94 (16): 1221-2. doi:10.1001/jama. ... adhesions of parietal peritoneum to liver.[citation needed] Treatment involves a course of antibiotics to cover the appropriate ...
This adhesion involves adhesins (e.g., hyphal wall protein 1), and extracellular polymeric materials (e.g., mannoprotein). ... Peleg AY, Hogan DA, Mylonakis E (May 2010). "Medically important bacterial-fungal interactions". Nature Reviews. Microbiology. ... In vitro and studies show that Candidal growth, adhesion and biofilm formation is enhanced by the presence of carbohydrates ... Therefore, strains of Candida with more adhesion capability have more pathogenic potential than other strains. The prevalence ...
Because of zinc's antibiotic nature, it is often used in many drugs against bacterial infections in humans. Inversely, due to ... The calcium bound proteins usually play an important role in cell-cell adhesion, hydrolytic processes (such as hydrolytic ... the bacterial nature of mitochondria, zinc antibiotics are also lethal to mitochondria and results in cell death at high ...
The glycosylation process is important for the ability of Kingella kingae to form bacterial aggregates and to bind to epithelia ... The Aggregatibacter aphrophilus glycosyltransferase is important for the adhesion of the bacterium to epithelia. In Haemophilus ... N-glycosyltransferases usually target adhesin proteins, which are involved in the attachment of bacterial cells to epithelia ( ... Nothaft H, Szymanski CM (March 2013). "Bacterial protein N-glycosylation: new perspectives and applications". The Journal of ...
Bacterial spores on the other hand cannot be killed by iodine, but they can be inhibited by iodophors. The growth of ... Designing effective antimicrobial surfaces demands an in-depth understanding of the initial microbe-surface adhesion mechanisms ... Bacterial endospores can be killed using this method. Both dry and moist heat are effective in eliminating microbial life. For ... When a bacterial enzyme comes in contact with a compound containing chlorine, the hydrogen atom in that molecule gets displaced ...
August 2008). "Pyogenic bacterial infections in humans with MyD88 deficiency". Science. 321 (5889): 691-6. Bibcode:2008Sci... ... chemokines and adhesion and costimulatory molecules, which in turn triggers acute inflammation and stimulation of adaptive ... male mutants had an increased susceptibility to bacterial infection. The MYD88 gene provides instructions for making a protein ... "Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections". Nature Immunology. 3 (1): 91-7 ...
This adhesion is also enhanced by the fatty acids in the lipoteichoic acid of the B. longum cell wall. B. longum is considered ... The persistence of B. longum in the gut is attributed to the glycoprotein-binding fimbriae structures and bacterial ... Type strain of Bifidobacterium longum at BacDive - the Bacterial Diversity Metadatabase New Strain of Bifidobacterium May Help ... polysaccharides, the latter of which possess strong electrostatic charges that aid in the adhesion of B. longum to intestinal ...
2. Bacterial degradation Gutta percha is made up of 14.5-21.8% Trans-1,4-Polyisoprene which can be degraded and form a visible ... 1. No sealability (no adhesion to dentine) It was concluded that gutta percha's drawback is the lack of seal. Failure of root ... Although a considerable reduction in bacterial cell by instrumentation and irrigation, viable bacteria can still be found in at ... anti-bacterial effect, non-toxic and no shrinkage nor expansion, chemical properties such as stability within the biological ...
... consisting of a hollow tube of protofilaments assembled from heterodimers of bacterial tubulin A (BtubA) and bacterial tubulin ... "Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase". Nature Cell Biology. 7 (6): ... Unlike eukaryotic microtubules, bacterial microtubules do not require chaperones to fold. In contrast to the 13 protofilaments ... Other bacterial microtubules have a ring of five protofilaments. Tubulin and microtubule-mediated processes, like cell ...
... and bacterial growth inside the appendix causing inflammation. The combination of inflammation, reduced blood flow to the ... bleeding and adhesions. Evidence indicates that a delay in obtaining surgery after admission results in no measurable ...
Both disease result in a loss of keratinocyte adhesion. Pemphigus can also be caused by a bacterial infection: bullous impetigo ... is a cell structure specialized for cell-to-cell adhesion. A type of junctional complex, they are localized spot-like adhesions ... Desmosomes are one of the stronger cell-to-cell adhesion types and are found in tissue that experience intense mechanical ... Extracellular calcium helps form the cadherin adhesion by allowing the cadherin extracellular domain on desmoglein and ...
Bacterial breakdown of leaf matter is also known to produce ammonium ions. It has been shown that foliar stable nitrogen ... In: S.N. Gorb (ed.) Functional Surfaces in Biology: Adhesion Related Phenomena. Volume 2. Springer. pp. 183-204. Adlassnig, W ... The bacterial communities found in the pitchers of this species have also been studied. The most recently described variety, N ... A complex bacterial community living in pitcher plant fluid. Jurnal Mikrobiologi Indonesia 11(1): 9-14. James Wong and the ...
... and bacterial and viral infections. AP-1 controls a number of cellular processes including differentiation, proliferation, and ... "Adenovirus-mediated overexpression of c-Jun and c-Fos induces intercellular adhesion molecule-1 and monocyte chemoattractant ...
Coutts AS, MacKenzie E, Griffith E, Black DM (March 2003). "TES is a novel focal adhesion protein with a role in cell spreading ... "Accumulation of profilin II at the surface of Listeria is concomitant with the onset of motility and correlates with bacterial ... April 2003). "The conformational state of Tes regulates its zyxin-dependent recruitment to focal adhesions". The Journal of ...
... bacterial conjugation - bacterial outer membrane protein - bacterial protein - bacteriorhodopsin - base (chemistry) - base pair ... cell adhesion molecule - cell biology - cell cycle protein - cell membrane - cell membrane transport - cell nucleus - cell ... intercellular adhesion molecule-1 - interferon receptor - interferon type I - interferon type II - interferon-alpha - ... neuronal cell adhesion molecule - neuropeptide - neuropeptide receptor - neuropeptide Y - neuropeptide Y receptor - ...
Cario, E (2005). "Bacterial interactions with cells of the intestinal mucosa: Toll-like receptors and NOD2". Gut. 54 (8): 1182- ... These complexes, consisting of transmembrane adhesion proteins of the cadherin family, link adjacent cells together through ...
... which is required for both mediating adhesion to the cell surface and for the subsequent membrane fusion process. To create ... Polyomaviruses Anelloviruses RNA viruses Caliciviruses Picornaviruses Reoviruses Astroviruses Hepeviridae Bacterial capsule ...
Mastromarino P, Vitali B, Mosca L (July 2013). "Bacterial vaginosis: a review on clinical trials with probiotics" (PDF). The ... Brouwer S, Barnett TC, Rivera-Hernandez T, Rohde M, Walker MJ (November 2016). "Streptococcus pyogenes adhesion and ... Mastromarino P, Vitali B, Mosca L (July 2013). "Bacterial vaginosis: a review on clinical trials with probiotics" (PDF). The ... José RJ, Periselneris JN, Brown JS (June 2020). "Opportunistic bacterial, viral and fungal infections of the lung". Medicine. ...
"Models for the bacterial iron-transport chelate enterochelin". Nature. 262 (5570): 722-724. Bibcode:1976Natur.262..722A. doi: ... "The Chemistry behind Catechol-Based Adhesion". Angewandte Chemie International Edition. 58 (3): 696-714. doi:10.1002/anie. ...
Kang HJ, Middleditch M, Proft T, Baker EN (December 2009). "Isopeptide bonds in bacterial pili and their characterization by X- ... Substrate proteins attached to cell walls by sortases include enzymes, pilins, and adhesion-mediating large surface ... Another sub-family of sortases (C60B in MEROPS) contains bacterial sortase B proteins that are approximately 200 residues long ... but also provide ingenious strategies for bacterial escape from the host's immune response. In the case of S. aureus protein A ...
Functional roles of lipids are in fact many: They serve as regulatory agents in cell growth and adhesion. They participate in ... 2007). "Environmental controls on bacterial tetraether membrane lipid distribution in soils". Geochimica et Cosmochimica Acta. ...
The SH3 domain is a point of contact with polyproline sequences on focal adhesion kinase (FAK). or the related kinase PTK2B, ... mild coagulation defects and propensity to recurrent bacterial and fungal infections, caused by incomplete phagocytosis due to ... However, the conserved functional properties of EFS relevant to cellular adhesion and migration, and RTK signaling, suggest ...
In the process of adhesion, bacteria often carry proteins on their surface, adhesins, that bind to specific components of ... Carbohydrate mediated bacterial adhesion Roland J Pieters. Adv Exp Med Biol. 2011. ... Intervention with bacterial adhesion by multivalent carbohydrates. Pieters RJ. Pieters RJ. Med Res Rev. 2007 Nov;27(6):796-816 ... The design and synthesis of inhibitors of bacterial adhesion has the potential to create new therapeutics for the prevention ...
... fastidiosa behavior from the point of view of gene expression and adhesion functionality. Bacterial adhesion is facilitated on ... Understanding the factors which influence bacterial adhesion and biofilm development is a key issue in identifying mechanisms ... Both biofilms and substrates were characterized at the micro- and nanoscale, which corresponds to the actual bacterial cell and ... Our results univocally support the hypothesis that different adhesion mechanisms are active along the biofilm life cycle ...
Adhesion of oral spirochaetes to host cells and its cytopathogenic consequences, p. 247-276. In M. Wilson (ed.), Bacterial ... Bacterial adhesion assays. Late-exponential-phase Treponema cells were biotinylated as previously described (12). Proteins, ... To determine the effects of rMsp on bacterial cell adhesion to immobilized fibronectin, rMsp (0 to 4 μg) was added to wells in ... To test inhibition of bacterial adhesion by antibodies, biotinylated T. denticola cells were incubated with rMsp antisera, or ...
TextPublication details: Totowa, N.J. : : Humana Press, , c2000. Description: 644 pSubject(s): Bacterial adhesion -- physiology ... Handbook of bacterial adhesion : : principles, methods, and applications / edited by Yuehuei H. An and Richard J. Friedman. ...
Bacterial adhesion not inhibited by ion-releasing bioactive glass filler. Bacterial adhesion not inhibited by ion-releasing ... The surface resistance against acid attack and the surface receptiveness for bacterial adhesion and biofilm formation of a sPRG ... Bacterial growth and biofilm formation were recorded using optical density and SEM. RESULTS:. Upon 3-day immersion in lactic ... Bacterial growth measurements revealed that none of the materials inhibited Streptococcus mutans (p. lactic acid in/around the ...
PROPERTIES (en) > physical properties (en) > adhesion (en) > cell adhesion (en) > bacterial adhesion (en) ...
The persistent issue of bacterial and fungal colonization of artificial implantable materials and the decreasing efficacy of ... Boland, T.; Latour, R.A.; Stutzenberger, F.J. Molecular basis of bacterial adhesion. In Handbook of Bacterial Adhesion; ... Bacterial Adhesion. Bacterial cells are essentially capable of attaching to all natural and artificial surfaces [24]. Yet it ... As the bacterial cell approaches the surface (a few nanometers), the initial stage of adhesion is governed by a number of ...
Programmable living assembly of materials by bacterial adhesion. 21 December 2021. Baizhu Chen, Wei Kang, … Zhuojun Dai ... The 48 h bacterial culture (500 ml) with CsgA-α, CsgA-γ or CsgA-αγ nanofibers was treated with 0.8 M (final concentration) ... In case of PQN4-BPA, the bacterial cells first were grown to OD 1 at 37 °C in 10 ml LB media with 100 µg ml−1 carbenicillin and ... Lehner, B. A. E., Schmieden, D. T. & Meyer, A. S. A straightforward approach for 3D bacterial printing. ACS Synth. Biol. 6, ...
Adhesion protein. Axenic (specific), Animal model. 1981. 35. Gram-positive bacteria. Tropheryma whipplei. Whipple disease. ... Traditional and Molecular Techniques for the Study of Emerging Bacterial Diseases: One Laboratorys Perspective Pierre ...
Box 8230 Department of Molecular Microbiology Washington University School of ...
Leukocyte Adhesion Deficiency (LAD). Leukocyte adhesion deficiency (LAD) is a rare, inherited immune disorder in which immune ... People with CVID experience frequent bacterial and viral infections of the upper airway, sinuses, and lungs. Read more about ... People with the disease have a weakened immune system and experience frequent bacterial and viral infections. Read more about ... This can result in prolonged episodes of bleeding, recurrent bacterial and fungal infections, and increased risk of cancers and ...
In this study, we analyzed the early stages of bacterial adhesion on two commercial dense polytetrafluoroethylene (d-PTFE) ... Bacterial contamination of the membranes used during guided bone regeneration directly influences the outcome of this procedure ... Bacterial properties were determined using the microbial adhesion to solvents (MATS) assay, and bacterial surface free energy ( ... Keywords: bacterial adhesion; d-PTFE membrane; guided bone regeneration; oral bacteria; polymer microstructure; ...
Bacterial Adhesion. EN. dc.subject. Cell Culture Techniques. EN. dc.subject. DNA Fingerprinting. EN. ...
Bacterial Adhesions use Bacterial Adhesion Bacterial Aneurysm use Aneurysm, Infected Bacterial Aneurysms use Aneurysm, Infected ... Bacterial Skin Diseases use Skin Diseases, Bacterial Bacterial Small Ribosomal Subunits use Ribosome Subunits, Small, Bacterial ... Bacterial Physiological Concept use Bacterial Physiological Phenomena Bacterial Physiological Concepts use Bacterial ... Bacterial Physiological Phenomenon use Bacterial Physiological Phenomena Bacterial Physiology use Bacterial Physiological ...
A Novel Surface Modification Strategy via Photopolymerized Poly-Sulfobetaine Methacrylate Coating to Prevent Bacterial Adhesion ...
Leukocyte adhesion deficiency type 1 is a disorder that causes the immune system to malfunction, resulting in a form of ... In leukocyte adhesion deficiency type 1, bacterial and fungal infections most commonly occur on the skin and mucous membranes ... Starting from birth, people with leukocyte adhesion deficiency type 1 develop serious bacterial and fungal infections. ... Leukocyte adhesion deficiency type 1 is a disorder that causes the immune system to malfunction, resulting in a form of ...
Cell adhesion molecules. *Cell signaling and receptors. *Composition and function of extracellular matrix ... Bacterial communication. *Biomimetics. *Bone/mineralized tissue formation, pathology, and gene expression. *Calcium signaling ...
... placebo-controlled trial to assess the bacterial anti-adhesion effects of cranberry extract beverages. Food Funct. 2015 Apr;6(4 ... A randomized, double-blind, placebo-controlled trial to assess the bacterial anti-adhesion effects of cranberry extract ... A randomized, double-blind, placebo-controlled trial to assess the bacterial anti-adhesion effects of cranberry extract ... Anti-adhesion, Antibacterial, Nutrition, Randomized Controlled Trial, Urinary system, Urinary Tract Infection, Vaccinium ...
... bacterial adhesion and infection ... Pneumococcal adhesion and infection of A549, BEAS-2B, and ... In A549 and BEAS-2B cells MS-WF increased pneumococcal adhesion and infection and PAFR protein expression. Both CV-3988 and N- ... Welders; Welders-lung; Welding; Welding-industry; Fumes; Metal-fumes; Occupational-diseases; Infection-control; Bacterial- ... on PAFR-dependent pneumococcal adhesion and infection to human airway cells in vitro and on pneumococcal airway infection in a ...
With few exceptions, bacterial deposition studies in a parallel plate (PP) flow chamber have revealed increasing cell adhesion ... MeSH Terms: Bacterial Adhesion; Disinfection/methods*; Escherichia coli O157/drug effects*; Escherichia coli O157/growth & ... the disinfection efficiency is limited by the successful transport of ROS to bacterial surfaces. This study was designed to ... with negatively charged SRHA reducing and positively charged α-Fe2O3 enhancing bacterial deposition significantly. Increased ...
Bacterial Adhesion Actions. * Search in PubMed * Search in MeSH * Add to Search ... percentage cytotoxicity of WT and mutant bacteria against cultured RAW 264.7 mouse macrophages exposed to the bacterial strains ...
interaction of multiple adhesions and receptors for bacterial adherence. *viral, bacterial, and host cell induction and release ... formation of bacterial biofilms in the chronic forms of OM. Because complex interactions between host and pathogen are likely ... Importantly, the bacterial phenotype is significantly altered in response to the inherent differences between the nasopharynx ... Also, the identification of the specific bacterial and viral ligands and host cell receptors mediating these processes is also ...
reason that because cranberry has been shown to inhibit bacterial adhesion to uroepithelial cells, it may also be useful as ... Additional, but more limited, research of cranberry because of its inhibition of bacterial adhesion and antioxidant properties ... bacterial adherence; o Evaluate relationship of cranberry/cranberry constituents and bacterial adherence to urinary pH; o Study ... Bacterial adherence to these cells is a critical step in the development of infection. It is facilitated by fimbriae ( ...
Bacterial adhesion on orthopedic implants.. Filipović U; Dahmane RG; Ghannouchi S; Zore A; Bohinc K. Adv Colloid Interface Sci ... 4. Biofilm formation, bacterial adhesion and host response on polymeric implants--issues and prevention.. Pavithra D; Doble M. ... 1. Bacterial adherence and biofilm formation on medical implants: a review.. Veerachamy S; Yarlagadda T; Manivasagam G; ...
Meredith, L., Mei, L., Farella, M., & Cannon, R. D. (2019). Bacterial adhesion to human enamel after enameloplasty. New Zealand ...
Keywords : Bacterial Adhesion, Bacterial Proteins, Fibronectins, gelatin, heparin, Humans, N-Acetylmuramoyl-L-alanine Amidase, ...
A ubiquitous organism, S pyogenes is the most common bacterial cause of acute pharyngitis, accounting for 15-30% of cases in ... Bacterial adherence factors. At least 11 different surface components of GAS have been suggested to play a role in adhesion. In ... whereas FBP54 mediates adhesion to buccal cells, but not to HEp-2 cells. Protein F mediates adhesion to Langerhans cells, but ... reversible adhesion. The second step takes the form of firm, irreversible adhesion mediated by tissue-specific M protein, ...
Prevention of nonspecific bacterial cell adhesion in immunoassays by use of cranberry juice. ... The ability of Vaccinum macrocarpon, the North American cranberry, to prevent bacterial adhesion has been used to advantage in ... RESULTS: Bacterial virulence mechanisms are critical for overcoming the normal host defenses. Increasing antimicrobial ... Under scanning and transmission electron microscopy, CJ was observed to inhibit the adsorption of phage T4 to its bacterial ...
Dehydrated mucosa raises the risk of viral adhesion. The repetitive application of compounds formulated to deliver ongoing " ... The cascade effect of dry mouth includes inflammation, sores, bacterial and fungal overgrowth (candida), gum disease, halitosis ...
  • 1. Bacterial adherence and biofilm formation on medical implants: a review. (
  • In the process of adhesion, bacteria often carry proteins on their surface, adhesins, that bind to specific components of tissue cells or the extracellular matrix. (
  • The major sheath (or surface) protein (Msp) of T. denticola is implicated in adhesion of bacteria to host cells and tissue proteins and is likely to be an important virulence factor. (
  • CGD occurs when white blood cells called phagocytes are unable to kill certain bacteria and fungi, making people highly susceptible to some bacterial and fungal infections. (
  • The adhesion of four species of oral bacteria ( Streptococcus mutans , Streptococcus oralis , Aggregatibacter actinomycetemcomitas , and Veilonella parvula ) was studied on surfaces with or without the artificial saliva coating. (
  • The ability of Vaccinum macrocarpon, the North American cranberry, to prevent bacterial adhesion has been used to advantage in the prevention of urinary tract infections and has recently been described for the prevention of adhesion of bacteria responsible for oral infections and stomach ulcers. (
  • This report documents the ability of cranberry juice to reduce nonspecific adhesion of bacteria to the borosilicate glass microscope slides used in an immunoarray biosensor format. (
  • Pathogenic bacteria express pili (also called 'fimbriae') on their surface for adhesion to their target cell: Shown here is an enterotoxigenic E. coli (ETEC) expressing CFA/I pili. (
  • Physicochemical property of fimbriated ( FIMBRIAE, BACTERIAL ) and non-fimbriated bacteria of attaching to cells, tissue, and nonbiological surfaces. (
  • Unfortunately, the carbohydrate structures often bind only weakly to the adhesion proteins, although drug design approaches can improve the situation. (
  • Besides adhesion inhibition as a potential therapeutic strategy, the adhesion proteins can also be used for detection. (
  • Leukocyte adhesion deficiency type 1 is a disorder that causes the immune system to malfunction, resulting in a form of immunodeficiency. (
  • Starting from birth, people with leukocyte adhesion deficiency type 1 develop serious bacterial and fungal infections. (
  • One of the first signs of leukocyte adhesion deficiency type 1 is a delay in the detachment of the umbilical cord stump after birth. (
  • but, in infants with leukocyte adhesion deficiency type 1, this separation usually occurs at three weeks or later. (
  • In leukocyte adhesion deficiency type 1, bacterial and fungal infections most commonly occur on the skin and mucous membranes such as the moist lining of the nose and mouth. (
  • A hallmark of leukocyte adhesion deficiency type 1 is the lack of pus formation at the sites of infection. (
  • Life expectancy in individuals with leukocyte adhesion deficiency type 1 is often severely shortened. (
  • Leukocyte adhesion deficiency type 1 is estimated to occur in 1 per million people worldwide. (
  • Mutations in the ITGB2 gene cause leukocyte adhesion deficiency type 1. (
  • ITGB2 gene mutations that cause leukocyte adhesion deficiency type 1 lead to the production of a β2 subunit that cannot bind with other subunits to form β2 integrins. (
  • Cox DP, Weathers DR. Leukocyte adhesion deficiency type 1: an important consideration in the clinical differential diagnosis of prepubertal periodontitis. (
  • Harris ES, Weyrich AS, Zimmerman GA. Lessons from rare maladies: leukocyte adhesion deficiency syndromes. (
  • Canine Leukocyte Adhesion Deficiency (CLAD) is not very common among dogs. (
  • Canine Leukocyte Adhesion Deficiency (CLAD) is an uncommon genetic condition that affects dogs, specifically those of the Irish Setters breed. (
  • Dog Leukocyte Adhesion Deficiency is caused by a genetic mutation in the ITGB2 gene. (
  • The design and synthesis of inhibitors of bacterial adhesion has the potential to create new therapeutics for the prevention and possibly treatment of bacterial infections. (
  • The persistent issue of bacterial and fungal colonization of artificial implantable materials and the decreasing efficacy of conventional systemic antibiotics used to treat implant-associated infections has led to the development of a wide range of antifouling and antibacterial strategies. (
  • People with CVID experience frequent bacterial and viral infections of the upper airway, sinuses, and lungs. (
  • Even when several UTIs in a row are due to E. coli, slight differences in the bacterial strains indicate distinct infections. (
  • One of the most common chronic bacterial oral infections, periodontitis, affects the supporting structures of the teeth. (
  • As a result, setters dogs with CLAD are unable to mount an effective immune response, making them more susceptible to bacterial, fungal, and viral infections. (
  • Dogs with CLAD are treated with antibiotics for bacterial infections. (
  • Animate and inanimate surfaces play a key role within the diffusion of Covid-19 and more generally of virus and bacterial infections. (
  • A series of "checkpoints" were envisioned where key molecules facilitate the process of bacterial colonization of the middle ear. (
  • It is a factor in bacterial colonization and pathogenicity. (
  • Strategies to prevent bacterial adhesion on biomaterials -- 8. (
  • 0.05) adhesion to all the cell lines and clones tested, when compared to the non-pathogenic strain HPTx30a. (
  • Bacterial growth and biofilm formation were recorded using optical density and SEM. (
  • 4. Biofilm formation, bacterial adhesion and host response on polymeric implants--issues and prevention. (
  • Bacterial meningitis in the United States in 1995. (
  • However, due to the extremely short lifetime of these radicals, the disinfection efficiency is limited by the successful transport of ROS to bacterial surfaces. (
  • Furthermore, interactions between collector surfaces and cells can be explained by electrostatic forces, with negatively charged SRHA reducing and positively charged α-Fe2O3 enhancing bacterial deposition significantly. (
  • We are examining the architecture of bacterial adhesion pili and investigating small molecules that disrupt their assembly and/or function. (
  • Structural polymorphism of bacterial adhesion pili. (
  • Impact of an alpha helix and a cysteine-cysteine disulfide bond on the resistance of bacterial adhesion pili to stress. (
  • The adhesion is further dependent on bacterial pathogenicity and the gastric cell line. (
  • Relevance of MUC1 mucin variable number of tandem repeats polymorphism in H pylori adhesion to gastric epithelial cells. (
  • Biofilms, bacterial communities of cells encased by a self-produced matrix, exhibit a variety of three-dimensional structures. (
  • Here, we study channel formation and focus on the role of the adhesion of the biofilm matrix to the substrate in Pseudomonas aeruginosa biofilms grown under constant flow in microfluidic channels. (
  • With few exceptions, bacterial deposition studies in a parallel plate (PP) flow chamber have revealed increasing cell adhesion with IS. (
  • E. coli source sub-group isolates were evaluated for the presence of genes associated with adhesion (afa/draBC, iha, agn43, eaeA and fimH), toxin production (hlyA, stx1, stx2), capsular polysaccharide synthesis (kpsMTII) and siderophores (iroNE.coli, chuA). (
  • Additional, but more limited, research of cranberry because of its inhibition of bacterial adhesion and antioxidant properties has been conducted for other infectious diseases and other conditions. (
  • In addition, affected infants often have inflammation of the umbilical cord stump (omphalitis) due to a bacterial infection. (
  • Objective: We sought to assess the effect of mild steel welding fumes (MS-WF) on PAFR-dependent pneumococcal adhesion and infection to human airway cells in vitro and on pneumococcal airway infection in a mouse model. (
  • Pneumococcal adhesion and infection of A549, BEAS-2B, and primary human bronchial airway cells were assessed by means of quantitative bacterial culture and expressed as colony-forming units (CFU). (
  • In A549 and BEAS-2B cells MS-WF increased pneumococcal adhesion and infection and PAFR protein expression. (
  • Both CV-3988 and N-acetylcysteine reduced MS-WF-stimulated pneumococcal adhesion and infection of airway cells. (
  • Conclusions: Hypersusceptibility of welders to pneumococcal pneumonia is in part mediated by the capacity of welding fumes to increase PAFR-dependent pneumococcal adhesion and infection of lower airway cells. (
  • The role of bacterial hydrophobicity in infection : bacterial adhesion and phagocytic ingestion. (
  • Importantly, the bacterial phenotype is significantly altered in response to the inherent differences between the nasopharynx and the middle ear space. (
  • Enzyme linked immunosorbent assay (ELISA)-based adhesion assays were performed to measure the adhesion of different H pylori strains (HP26695 and HPTx30a) to gastric carcinoma cell lines (GP202 and MKN45) and GP202 clones expressing recombinant MUC1 with different VNTR lengths. (
  • However, the concentration of ions released by both materials appeared not sufficient to inhibit bacterial growth . (
  • The formation of the wrinkles and folds is triggered by a mechanical buckling instability, controlled by biofilm growth rate and the film's adhesion to the substrate. (
  • All bacterial species adhered better to a highly crystalline membrane (around 1 log 10 CFU/mL difference), both with and without artificial saliva coating. (
  • Intervention with bacterial adhesion by multivalent carbohydrates. (
  • Clean-catch urine samples collected at baseline and post intervention were tested for anti-adhesion activity utilizing a mannose-resistant human red blood cell hemagglutination assay specific for P-fimbriated E. coli. (
  • This FOA will also encourage the conduct of human intervention studies that identify inter-individual variability among various racial and ethnic groups in the production of bacterial metabolites and determine their efficacy in cancer prevention. (
  • Prevention of nonspecific bacterial cell adhesion in immunoassays by use of cranberry juice. (
  • A randomized, double-blind, placebo-controlled trial to assess the bacterial anti-adhesion effects of cranberry extract beverages. (
  • In this study, we examined the ex vivo urinary anti-adhesion activity of low-calorie cranberry extract beverages in both a pilot study (n = 10) and a randomized, double-blind, placebo controlled clinical trial (n = 59). (
  • Results from the pilot study indicated that ex vivo anti-adhesion activity for both cranberry treatments were higher (p (
  • Therefore, acute beverage consumption of cranberry extract and/or juice provides ex vivo anti-adhesion activity, which may help to improve urinary tract health. (
  • Cell surface carbohydrates in cell adhesion. (
  • As originally described by Lancefield, beta-hemolytic streptococci can be divided into many groups based on the antigenic differences in group-specific polysaccharides located in the bacterial cell wall. (
  • 0.05) adhesion to the GP202 cell line, when compared to the MKN45 cell line. (
  • Bacterial meningitis in the United States, 1986: report of a multistate surveillance study. (
  • Antibodies to the N-region or V-region polypeptides, but not antibodies to the rC-Msp fragment, blocked adhesion of T. denticola ATCC 35405 cells to a range of host protein molecules. (
  • There were no differences observed in anti-adhesion activity between CJEB and LCJC, indicating similar bioactivity. (
  • The three-dimensional folding gives rise to hollow channels that rapidly increase the effective volume occupied by the biofilm and facilitate bacterial movement inside them. (
  • These results suggest that the N-terminal half of Msp carries epitopes that are surface exposed and that are involved in mediating adhesion. (
  • Bacterial properties were determined using the microbial adhesion to solvents (MATS) assay, and bacterial surface free energy (SFE) was measured spectrophotometrically. (
  • The results indicated that the degree of crystallinity (78.6% vs. 34.2%, with average crystallite size 50.54 nm vs. 32.86 nm) is the principal feature promoting the adhesion strength, through lower nanoscale roughness and possibly higher surface stiffness. (
  • We see that pilin subunits must rotate to form a helical filament, after exiting linearly from the bacterial surface. (
  • To evaluate the influence of MUC1 mucin variable number of tandem repeats (VNTR) variability on H pylori adhesion to gastric cells. (
  • Specific immune response in the respiratory tract after administration of an oral polyvalent bacterial vaccine. (
  • In this study, we analyzed the early stages of bacterial adhesion on two commercial dense polytetrafluoroethylene (d-PTFE) membranes in order to identify microstructural features that led to different adhesion strengths. (
  • A ubiquitous organism, S pyogenes is the most common bacterial cause of acute pharyngitis , accounting for 15-30% of cases in children and 5-10% of cases in adults. (
  • Handbook of bacterial adhesion : : principles, methods, and applications / edited by Yuehuei H. An and Richard J. Friedman. (