Cell Adhesion Molecules
Adhesins, Escherichia coli
Intercellular Adhesion Molecule-1
Microscopy, Atomic Force
Vascular Cell Adhesion Molecule-1
Coated Materials, Biocompatible
Prostheses and Implants
Focal Adhesion Kinase 1
Focal Adhesion Protein-Tyrosine Kinases
Microscopy, Electron, Scanning
Bacterial Outer Membrane Proteins
Hydrophobic and Hydrophilic Interactions
Molecular Sequence Data
Neural Cell Adhesion Molecules
Amino Acid Sequence
Cell Adhesion Molecules, Neuronal
Colony Count, Microbial
Gene Expression Regulation, Bacterial
Lymphocyte Function-Associated Antigen-1
Neural Cell Adhesion Molecule L1
Focal Adhesion Kinase 2
Junctional Adhesion Molecules
Receptors, Lymphocyte Homing
Role of antibodies against Bordetella pertussis virulence factors in adherence of Bordetella pertussis and Bordetella parapertussis to human bronchial epithelial cells. (1/5458)Immunization with whole-cell pertussis vaccines (WCV) containing heat-killed Bordetella pertussis cells and with acellular vaccines containing genetically or chemically detoxified pertussis toxin (PT) in combination with filamentous hemagglutinin (FHA), pertactin (Prn), or fimbriae confers protection in humans and animals against B. pertussis infection. In an earlier study we demonstrated that FHA is involved in the adherence of these bacteria to human bronchial epithelial cells. In the present study we investigated whether mouse antibodies directed against B. pertussis FHA, PTg, Prn, and fimbriae, or against two other surface molecules, lipopolysaccharide (LPS) and the 40-kDa outer membrane porin protein (OMP), that are not involved in bacterial adherence, were able to block adherence of B. pertussis and B. parapertussis to human bronchial epithelial cells. All antibodies studied inhibited the adherence of B. pertussis to these epithelial cells and were equally effective in this respect. Only antibodies against LPS and 40-kDa OMP affected the adherence of B. parapertussis to epithelial cells. We conclude that antibodies which recognize surface structures on B. pertussis or on B. parapertussis can inhibit adherence of the bacteria to bronchial epithelial cells, irrespective whether these structures play a role in adherence of the bacteria to these cells. (+info)
Role of Bordetella pertussis virulence factors in adherence to epithelial cell lines derived from the human respiratory tract. (2/5458)During colonization of the respiratory tract by Bordetella pertussis, virulence factors contribute to adherence of the bacterium to the respiratory tract epithelium. In the present study, we examined the roles of the virulence factors filamentous hemagglutinin (FHA), fimbriae, pertactin (Prn), and pertussis toxin (PT) in the adherence of B. pertussis to cells of the human bronchial epithelial cell line NCI-H292 and of the laryngeal epithelial cell line HEp-2. Using B. pertussis mutant strains and purified FHA, fimbriae, Prn, and PT, we demonstrated that both fimbriae and FHA are involved in the adhesion of B. pertussis to laryngeal epithelial cells, whereas only FHA is involved in the adherence to bronchial epithelial cells. For PT and Prn, no role as adhesion factor was found. However, purified PT bound to both bronchial and laryngeal cells and as such reduced the adherence of B. pertussis to these cells. These data may imply that fimbriae play a role in infection of only the laryngeal mucosa, while FHA is the major factor in colonization of the entire respiratory tract. (+info)
Enhanced adhesion of Pasteurella multocida to cultured turkey peripheral blood monocytes. (3/5458)Capsular hyaluronic acid (HA) mediates adhesion of serogroup A strains of Pasteurella multocida to elicited turkey air sac macrophages (TASM). In contrast, freshly isolated turkey peripheral blood monocytes (TPBM) do not bind serogroup A strains. Following culture of TPBM for 6 days in chamber slides, adhesion of the bacteria to TPBM increased gradually. Incubation in chamber slides coated with entactin-collagen IV-laminin (ECL) attachment matrix or exposure to phorbol myristate acetate (PMA) further enhanced the adhesion of P. multocida to TPBM. Addition of HA, but not Arg-Gly-Asp peptide, to TPBM culture inhibited bacterial adherence similarly to the inhibition previously reported for TASM. Exposure of TPBM to monoclonal antibody directed against HA-binding cell surface proteoglycan (CD44) decreased binding of P. multocida. Collectively, these findings indicate that P. multocida adhesion to TPBM is mediated by capsular HA and can be increased by culture on ECL attachment matrix or PMA exposure. Additionally, the findings suggest that the capsular mucopolysaccharide of serogroup A strains of P. multocida recognizes an isoform of CD44 expressed on cultured TPBM. (+info)
Genetic characterization of a new type IV-A pilus gene cluster found in both classical and El Tor biotypes of Vibrio cholerae. (4/5458)The Vibrio cholerae genome contains a 5.4-kb pil gene cluster that resembles the Aeromonas hydrophila tap gene cluster and other type IV-A pilus assembly operons. The region consists of five complete open reading frames designated pilABCD and yacE, based on the nomenclature of related genes from Pseudomonas aeruginosa and Escherichia coli K-12. This cluster is present in both classical and El Tor biotypes, and the pilA and pilD genes are 100% conserved. The pilA gene encodes a putative type IV pilus subunit. However, deletion of pilA had no effect on either colonization of infant mice or adherence to HEp-2 cells, demonstrating that pilA does not encode the primary subunit of a pilus essential for these processes. The pilD gene product is similar to other type IV prepilin peptidases, proteins that process type IV signal sequences. Mutational analysis of the pilD gene showed that pilD is essential for secretion of cholera toxin and hemagglutinin-protease, mannose-sensitive hemagglutination (MSHA), production of toxin-coregulated pili, and colonization of infant mice. Defects in these functions are likely due to the lack of processing of N termini of four Eps secretion proteins, four proteins of the MSHA cluster, and TcpB, all of which contain type IV-A leader sequences. Some pilD mutants also showed reduced adherence to HEp-2 cells, but this defect could not be complemented in trans, indicating that the defect may not be directly due to a loss of pilD. Taken together, these data demonstrate the effectiveness of the V. cholerae genome project for rapid identification and characterization of potential virulence factors. (+info)
Molecular basis for the enterocyte tropism exhibited by Salmonella typhimurium type 1 fimbriae. (5/5458)Salmonella typhimurium exhibits a distinct tropism for mouse enterocytes that is linked to their expression of type 1 fimbriae. The distinct binding traits of Salmonella type 1 fimbriae is also reflected in their binding to selected mannosylated proteins and in their ability to promote secondary bacterial aggregation on enterocyte surfaces. The determinant of binding in Salmonella type 1 fimbriae is a 35-kDa structurally distinct fimbrial subunit, FimHS, because inactivation of fimHS abolished binding activity in the resulting mutant without any apparent effect on fimbrial expression. Surprisingly, when expressed in the absence of other fimbrial components and as a translational fusion protein with MalE, FimHS failed to demonstrate any specific binding tropism and bound equally to all cells and mannosylated proteins tested. To determine if the binding specificity of Salmonella type 1 fimbriae was determined by the fimbrial shaft that is intimately associated with FimHS, we replaced the amino-terminal half of FimHS with the corresponding sequence from Escherichia coli FimH (FimHE) that contains the receptor binding domain of FimHE. The resulting hybrid fimbriae bearing FimHES on a Salmonella fimbrial shaft exhibited binding traits that resembled that of Salmonella rather than E. coli fimbriae. Apparently, the quaternary constraints imposed by the fimbrial shaft on the adhesin determine the distinct binding traits of S. typhimurium type 1 fimbriae. (+info)
P fimbriae and other adhesins enhance intestinal persistence of Escherichia coli in early infancy. (6/5458)Resident and transient Escherichia coli strains were identified in the rectal flora of 22 Pakistani infants followed from birth to 6 months of age. All strains were tested for O-antigen expression, adhesin specificity (P fimbriae, other mannose-resistant adhesins or type 1 fimbriae) and adherence to the colonic cell line HT-29. Resident strains displayed higher mannose-resistant adherence to HT-29 cells, and expressed P fimbriae (P = 0.0036) as well as other mannose-resistant adhesins (P = 0.012) more often than transient strains. In strains acquired during the first month of life, P fimbriae were 12 times more frequent in resident than in transient strains (P = 0.0006). The O-antigen distribution did not differ between resident and transient strains, and none of the resident P-fimbriated strains belonged to previously recognized uropathogenic clones. The results suggest that adhesins mediating adherence to intestinal epithelial cells, especially P fimbriae, enhance the persistence of E. coli in the large intestine of infants. (+info)
Roles of Pseudomonas aeruginosa las and rhl quorum-sensing systems in control of twitching motility. (7/5458)Pseudomonas aeruginosa is a ubiquitous environmental bacterium and an important human pathogen. The production of several virulence factors by P. aeruginosa is controlled through two quorum-sensing systems, las and rhl. We have obtained evidence that both the las and rhl quorum-sensing systems are also required for type 4 pilus-dependent twitching motility and infection by the pilus-specific phage D3112cts. Mutants which lack the ability to synthesize PAI-1, PAI-2, or both autoinducers were significantly or greatly impaired in twitching motility and in susceptibility to D3112cts. Twitching motility and phage susceptibility in the autoinducer-deficient mutants were partially restored by exposure to exogenous PAI-1 and PAI-2. Both twitching motility and infection by pilus-specific phage are believed to be dependent on the extension and retraction of polar type 4 pili. Western blot analysis of whole-cell lysates and enzyme-linked immunosorbent assays of intact cells were used to measure the amounts of pilin on the cell surfaces of las and rhl mutants relative to that of the wild type. It appears that PAI-2 plays a crucial role in twitching motility and phage infection by affecting the export and assembly of surface type 4 pili. The ability of P. aeruginosa cells to adhere to human bronchial epithelial cells was also found to be dependent on the rhl quorum-sensing system. Microscopic analysis of twitching motility indicated that mutants which were unable to synthesize PAI-1 were defective in the maintenance of cellular monolayers and migrating packs of cells. Thus, PAI-1 appears to have an essential role in maintaining cell-cell spacing and associations required for effective twitching motility. (+info)
Cell surface-associated lipoteichoic acid acts as an adhesion factor for attachment of Lactobacillus johnsonii La1 to human enterocyte-like Caco-2 cells. (8/5458)The influence of pH on the adhesion of two Lactobacillus strains to Caco-2 human intestinal cells was investigated. One strain, Lactobacillus johnsonii La1, was adherent at any pH between 4 and 7. The other one, L. acidophilus La10, did not attach to this cell line under the same experimental conditions. On the basis of these results, we used the monoclonal antibody technique as a tool to determine differences on the surface of these bacteria and to identify a factor for adhesion. Mice were immunized with live La1, and the hybridomas produced by fusion of spleen cells with ONS1 cells were screened for the production of antibodies specific for L. johnsonii La1. A set of these monoclonal antibodies was directed against a nonproteinaceous component of the L. johnsonii La1 surface. It was identified as lipoteichoic acid (LTA). This molecule was isolated, chemically characterized, and tested in adhesion experiments in the same system. The adhesion of L. johnsonii La1 to Caco-2 cells was inhibited in a concentration-dependent way by purified LTA as well as by L. johnsonii La1 culture supernatant that contained LTA. These results showed that the mechanism of adhesion of L. johnsonii La1 to human Caco-2 cells involves LTA. (+info)
Examples of how 'Tissue Adhesions' is used in the medical field:
1. In gastrointestinal surgery, tissue adhesions can form between the intestines and other organs, leading to bowel obstruction, inflammation, or other complications.
2. In cardiovascular surgery, tissue adhesions can form between the heart and surrounding tissues, causing impaired heart function and increasing the risk of postoperative complications.
3. In gynecological surgery, tissue adhesions can form between the uterus and other pelvic organs, leading to pain, bleeding, and infertility.
4. In oncologic surgery, tissue adhesions can form between cancerous tissues and surrounding normal tissues, making it difficult to remove the tumor completely.
5. In chronic diseases such as endometriosis, tissue adhesions can form between the uterus and other pelvic structures, leading to pain and infertility.
6. Tissue adhesions can also form within the skin, causing keloids or other types of scarring.
Treatment options for tissue adhesions depend on the location, size, and severity of the adhesions, as well as the underlying cause. Some common treatment options include:
1. Surgical removal of adhesions: This involves surgically removing the fibrous bands or scar tissue that are causing the adhesions.
2. Steroid injections: Injecting steroids into the affected area can help reduce inflammation and shrink the adhesions.
3. Physical therapy: Gentle stretching and exercise can help improve range of motion and reduce stiffness in the affected area.
4. Radiofrequency ablation: This is a minimally invasive procedure that uses heat to break down and remove the fibrous bands causing the adhesions.
5. Laser therapy: Laser therapy can be used to break down and remove the fibrous bands causing the adhesions, or to reduce inflammation and promote healing.
6. Natural remedies: Some natural remedies such as turmeric, ginger, and omega-3 fatty acids have anti-inflammatory properties and may help reduce inflammation and improve symptoms.
Preventing tissue adhesions is not always possible, but there are some measures that can be taken to reduce the risk of their formation. These include:
1. Proper wound care: Keeping wounds clean and dry, and using sterile dressings can help prevent infection and reduce the risk of adhesion formation.
2. Minimizing trauma: Avoiding unnecessary trauma to the affected area can help reduce the risk of adhesion formation.
3. Gentle exercise: Gentle exercise and stretching after surgery or injury can help improve range of motion and reduce stiffness in the affected area.
4. Early mobilization: Early mobilization after surgery or injury can help reduce the risk of adhesion formation.
5. Avoiding smoking: Smoking can impede wound healing and increase the risk of adhesion formation, so avoiding smoking is recommended.
6. Using anti-adhesive agents: Applying anti-adhesive agents such as silicone or hydrogel to the affected area after surgery or injury can help reduce the risk of adhesion formation.
It's important to note that the most effective method for preventing or treating tissue adhesions will depend on the specific cause and location of the adhesions, as well as the individual patient's needs and medical history. A healthcare professional should be consulted for proper evaluation and treatment.
Here are some common types of E. coli infections:
1. Urinary tract infections (UTIs): E. coli is a leading cause of UTIs, which occur when bacteria enter the urinary tract and cause inflammation. Symptoms include frequent urination, burning during urination, and cloudy or strong-smelling urine.
2. Diarrheal infections: E. coli can cause diarrhea, abdominal cramps, and fever if consumed through contaminated food or water. In severe cases, this type of infection can lead to dehydration and even death, particularly in young children and the elderly.
3. Septicemia (bloodstream infections): If E. coli bacteria enter the bloodstream, they can cause septicemia, a life-threatening condition that requires immediate medical attention. Symptoms include fever, chills, rapid heart rate, and low blood pressure.
4. Meningitis: In rare cases, E. coli infections can spread to the meninges, the protective membranes covering the brain and spinal cord, causing meningitis. This is a serious condition that requires prompt treatment with antibiotics and supportive care.
5. Hemolytic-uremic syndrome (HUS): E. coli infections can sometimes cause HUS, a condition where the bacteria destroy red blood cells, leading to anemia, kidney failure, and other complications. HUS is most common in young children and can be fatal if not treated promptly.
Preventing E. coli infections primarily involves practicing good hygiene, such as washing hands regularly, especially after using the bathroom or before handling food. It's also essential to cook meat thoroughly, especially ground beef, to avoid cross-contamination with other foods. Avoiding unpasteurized dairy products and drinking contaminated water can also help prevent E. coli infections.
If you suspect an E. coli infection, seek medical attention immediately. Your healthcare provider may perform a urine test or a stool culture to confirm the diagnosis and determine the appropriate treatment. In mild cases, symptoms may resolve on their own within a few days, but antibiotics may be necessary for more severe infections. It's essential to stay hydrated and follow your healthcare provider's recommendations to ensure a full recovery.
Staphylococcal infections can be classified into two categories:
1. Methicillin-Resistant Staphylococcus Aureus (MRSA) - This type of infection is resistant to many antibiotics and can cause severe skin infections, pneumonia, bloodstream infections and surgical site infections.
2. Methicillin-Sensitive Staphylococcus Aureus (MSSA) - This type of infection is not resistant to antibiotics and can cause milder skin infections, respiratory tract infections, sinusitis and food poisoning.
Staphylococcal infections are caused by the Staphylococcus bacteria which can enter the body through various means such as:
1. Skin cuts or open wounds
2. Respiratory tract infections
3. Contaminated food and water
4. Healthcare-associated infections
5. Surgical site infections
Symptoms of Staphylococcal infections may vary depending on the type of infection and severity, but they can include:
1. Skin redness and swelling
2. Increased pain or tenderness
3. Warmth or redness in the affected area
4. Pus or discharge
5. Fever and chills
6. Swollen lymph nodes
7. Shortness of breath
Diagnosis of Staphylococcal infections is based on physical examination, medical history, laboratory tests such as blood cultures, and imaging studies such as X-rays or CT scans.
Treatment of Staphylococcal infections depends on the type of infection and severity, but may include:
1. Antibiotics to fight the infection
2. Drainage of abscesses or pus collection
3. Wound care and debridement
4. Supportive care such as intravenous fluids, oxygen therapy, and pain management
5. Surgical intervention in severe cases.
Preventive measures for Staphylococcal infections include:
1. Good hand hygiene practices
2. Proper cleaning and disinfection of surfaces and equipment
3. Avoiding close contact with people who have Staphylococcal infections
4. Covering wounds and open sores
5. Proper sterilization and disinfection of medical equipment.
It is important to note that MRSA (methicillin-resistant Staphylococcus aureus) is a type of Staphylococcal infection that is resistant to many antibiotics, and can be difficult to treat. Therefore, early diagnosis and aggressive treatment are crucial to prevent complications and improve outcomes.
Some common types of peritoneal diseases include:
1. Peritonitis: This is an inflammation of the peritoneum, often caused by bacterial or viral infections.
2. Ascites: This is the accumulation of fluid in the abdominal cavity, which can be caused by a variety of factors, including liver disease, kidney failure, and cancer.
3. Peritoneal mesothelioma: This is a type of cancer that affects the peritoneum, often causing abdominal pain, bowel obstruction, and weight loss.
4. Omental torsion: This is a rare condition in which the omentum (a fold of peritoneum that covers the intestines) becomes twisted, cutting off blood supply to the intestines.
5. Peritoneal coccidiosis: This is an infection caused by the parasite Isospora belli, which can cause diarrhea, weight loss, and other gastrointestinal symptoms.
Peritoneal diseases can be diagnosed through a variety of tests, including abdominal imaging, blood tests, and biopsies. Treatment options vary depending on the specific type of disease and its severity, but may include antibiotics, surgery, or chemotherapy.
Bacterial adhesion in aquatic system
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Fluidic force microscopy
YadA bacterial adhesin protein domain
Leukocyte adhesion deficiency
Trimeric autotransporter adhesin
David B. Dusenbery
Membrane vesicle trafficking
Filamentous haemagglutinin adhesin
Rocky Mountain spotted fever
AP-1 transcription factor
Index of biochemistry articles
Embryonal fyn-associated substrate
Carbohydrate mediated bacterial adhesion - PubMed
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Binding Properties and Adhesion-Mediating Regions of the Major Sheath Protein of Treponema denticola ATCC 35405 - PMC
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Bacterial adhesion not inhibited by ion-releasing bioactive glass filler. | Dent Mater;33(6): 723-734, 2017 06. | MEDLINE
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Group A Streptococcal (GAS) Infections: Background, Pathophysiology, Etiology
Health Research Library | 2010 | Cranberry Institute
The Physiological Burden of Prolonged PPE Use on Healthcare Workers during Long Shifts | Blogs | CDC
- 1. Bacterial adherence and biofilm formation on medical implants: a review. (nih.gov)
- In the process of adhesion, bacteria often carry proteins on their surface, adhesins, that bind to specific components of tissue cells or the extracellular matrix. (nih.gov)
- The major sheath (or surface) protein (Msp) of T. denticola is implicated in adhesion of bacteria to host cells and tissue proteins and is likely to be an important virulence factor. (nih.gov)
- CGD occurs when white blood cells called phagocytes are unable to kill certain bacteria and fungi, making people highly susceptible to some bacterial and fungal infections. (nih.gov)
- The adhesion of four species of oral bacteria ( Streptococcus mutans , Streptococcus oralis , Aggregatibacter actinomycetemcomitas , and Veilonella parvula ) was studied on surfaces with or without the artificial saliva coating. (nih.gov)
- The ability of Vaccinum macrocarpon, the North American cranberry, to prevent bacterial adhesion has been used to advantage in the prevention of urinary tract infections and has recently been described for the prevention of adhesion of bacteria responsible for oral infections and stomach ulcers. (cranberryinstitute.org)
- This report documents the ability of cranberry juice to reduce nonspecific adhesion of bacteria to the borosilicate glass microscope slides used in an immunoarray biosensor format. (cranberryinstitute.org)
- Pathogenic bacteria express pili (also called 'fimbriae') on their surface for adhesion to their target cell: Shown here is an enterotoxigenic E. coli (ETEC) expressing CFA/I pili. (bu.edu)
- Physicochemical property of fimbriated ( FIMBRIAE, BACTERIAL ) and non-fimbriated bacteria of attaching to cells, tissue, and nonbiological surfaces. (nih.gov)
Leukocyte adhesion d15
- Leukocyte adhesion deficiency type 1 is a disorder that causes the immune system to malfunction, resulting in a form of immunodeficiency. (medlineplus.gov)
- Starting from birth, people with leukocyte adhesion deficiency type 1 develop serious bacterial and fungal infections. (medlineplus.gov)
- One of the first signs of leukocyte adhesion deficiency type 1 is a delay in the detachment of the umbilical cord stump after birth. (medlineplus.gov)
- but, in infants with leukocyte adhesion deficiency type 1, this separation usually occurs at three weeks or later. (medlineplus.gov)
- In leukocyte adhesion deficiency type 1, bacterial and fungal infections most commonly occur on the skin and mucous membranes such as the moist lining of the nose and mouth. (medlineplus.gov)
- A hallmark of leukocyte adhesion deficiency type 1 is the lack of pus formation at the sites of infection. (medlineplus.gov)
- Life expectancy in individuals with leukocyte adhesion deficiency type 1 is often severely shortened. (medlineplus.gov)
- Leukocyte adhesion deficiency type 1 is estimated to occur in 1 per million people worldwide. (medlineplus.gov)
- Mutations in the ITGB2 gene cause leukocyte adhesion deficiency type 1. (medlineplus.gov)
- ITGB2 gene mutations that cause leukocyte adhesion deficiency type 1 lead to the production of a β2 subunit that cannot bind with other subunits to form β2 integrins. (medlineplus.gov)
- Cox DP, Weathers DR. Leukocyte adhesion deficiency type 1: an important consideration in the clinical differential diagnosis of prepubertal periodontitis. (medlineplus.gov)
- Harris ES, Weyrich AS, Zimmerman GA. Lessons from rare maladies: leukocyte adhesion deficiency syndromes. (medlineplus.gov)
- Canine Leukocyte Adhesion Deficiency (CLAD) is not very common among dogs. (petcarerx.com)
- Canine Leukocyte Adhesion Deficiency (CLAD) is an uncommon genetic condition that affects dogs, specifically those of the Irish Setters breed. (petcarerx.com)
- Dog Leukocyte Adhesion Deficiency is caused by a genetic mutation in the ITGB2 gene. (petcarerx.com)
- The design and synthesis of inhibitors of bacterial adhesion has the potential to create new therapeutics for the prevention and possibly treatment of bacterial infections. (nih.gov)
- The persistent issue of bacterial and fungal colonization of artificial implantable materials and the decreasing efficacy of conventional systemic antibiotics used to treat implant-associated infections has led to the development of a wide range of antifouling and antibacterial strategies. (mdpi.com)
- People with CVID experience frequent bacterial and viral infections of the upper airway, sinuses, and lungs. (nih.gov)
- Even when several UTIs in a row are due to E. coli, slight differences in the bacterial strains indicate distinct infections. (nih.gov)
- One of the most common chronic bacterial oral infections, periodontitis, affects the supporting structures of the teeth. (medscape.com)
- As a result, setters dogs with CLAD are unable to mount an effective immune response, making them more susceptible to bacterial, fungal, and viral infections. (petcarerx.com)
- Dogs with CLAD are treated with antibiotics for bacterial infections. (petcarerx.com)
- Animate and inanimate surfaces play a key role within the diffusion of Covid-19 and more generally of virus and bacterial infections. (frontiersin.org)
- Strategies to prevent bacterial adhesion on biomaterials -- 8. (stanford.edu)
- 0.05) adhesion to all the cell lines and clones tested, when compared to the non-pathogenic strain HPTx30a. (nih.gov)
- Bacterial meningitis in the United States in 1995. (cdc.gov)
- However, due to the extremely short lifetime of these radicals, the disinfection efficiency is limited by the successful transport of ROS to bacterial surfaces. (nih.gov)
- Furthermore, interactions between collector surfaces and cells can be explained by electrostatic forces, with negatively charged SRHA reducing and positively charged α-Fe2O3 enhancing bacterial deposition significantly. (nih.gov)
- We are examining the architecture of bacterial adhesion pili and investigating small molecules that disrupt their assembly and/or function. (bu.edu)
- Structural polymorphism of bacterial adhesion pili. (bu.edu)
- Impact of an alpha helix and a cysteine-cysteine disulfide bond on the resistance of bacterial adhesion pili to stress. (bu.edu)
- The adhesion is further dependent on bacterial pathogenicity and the gastric cell line. (nih.gov)
- Relevance of MUC1 mucin variable number of tandem repeats polymorphism in H pylori adhesion to gastric epithelial cells. (nih.gov)
- Biofilms, bacterial communities of cells encased by a self-produced matrix, exhibit a variety of three-dimensional structures. (elifesciences.org)
- Here, we study channel formation and focus on the role of the adhesion of the biofilm matrix to the substrate in Pseudomonas aeruginosa biofilms grown under constant flow in microfluidic channels. (elifesciences.org)
- With few exceptions, bacterial deposition studies in a parallel plate (PP) flow chamber have revealed increasing cell adhesion with IS. (nih.gov)
- E. coli source sub-group isolates were evaluated for the presence of genes associated with adhesion (afa/draBC, iha, agn43, eaeA and fimH), toxin production (hlyA, stx1, stx2), capsular polysaccharide synthesis (kpsMTII) and siderophores (iroNE.coli, chuA). (usda.gov)
- Additional, but more limited, research of cranberry because of its inhibition of bacterial adhesion and antioxidant properties has been conducted for other infectious diseases and other conditions. (nih.gov)
- In addition, affected infants often have inflammation of the umbilical cord stump (omphalitis) due to a bacterial infection. (medlineplus.gov)
- Objective: We sought to assess the effect of mild steel welding fumes (MS-WF) on PAFR-dependent pneumococcal adhesion and infection to human airway cells in vitro and on pneumococcal airway infection in a mouse model. (cdc.gov)
- Pneumococcal adhesion and infection of A549, BEAS-2B, and primary human bronchial airway cells were assessed by means of quantitative bacterial culture and expressed as colony-forming units (CFU). (cdc.gov)
- In A549 and BEAS-2B cells MS-WF increased pneumococcal adhesion and infection and PAFR protein expression. (cdc.gov)
- Both CV-3988 and N-acetylcysteine reduced MS-WF-stimulated pneumococcal adhesion and infection of airway cells. (cdc.gov)
- Conclusions: Hypersusceptibility of welders to pneumococcal pneumonia is in part mediated by the capacity of welding fumes to increase PAFR-dependent pneumococcal adhesion and infection of lower airway cells. (cdc.gov)
- The role of bacterial hydrophobicity in infection : bacterial adhesion and phagocytic ingestion. (who.int)
- Importantly, the bacterial phenotype is significantly altered in response to the inherent differences between the nasopharynx and the middle ear space. (nih.gov)
- Enzyme linked immunosorbent assay (ELISA)-based adhesion assays were performed to measure the adhesion of different H pylori strains (HP26695 and HPTx30a) to gastric carcinoma cell lines (GP202 and MKN45) and GP202 clones expressing recombinant MUC1 with different VNTR lengths. (nih.gov)
- However, the concentration of ions released by both materials appeared not sufficient to inhibit bacterial growth . (bvsalud.org)
- The formation of the wrinkles and folds is triggered by a mechanical buckling instability, controlled by biofilm growth rate and the film's adhesion to the substrate. (elifesciences.org)
- All bacterial species adhered better to a highly crystalline membrane (around 1 log 10 CFU/mL difference), both with and without artificial saliva coating. (nih.gov)
- Intervention with bacterial adhesion by multivalent carbohydrates. (nih.gov)
- Clean-catch urine samples collected at baseline and post intervention were tested for anti-adhesion activity utilizing a mannose-resistant human red blood cell hemagglutination assay specific for P-fimbriated E. coli. (herbal.guide)
- This FOA will also encourage the conduct of human intervention studies that identify inter-individual variability among various racial and ethnic groups in the production of bacterial metabolites and determine their efficacy in cancer prevention. (nih.gov)
- Prevention of nonspecific bacterial cell adhesion in immunoassays by use of cranberry juice. (cranberryinstitute.org)
- A randomized, double-blind, placebo-controlled trial to assess the bacterial anti-adhesion effects of cranberry extract beverages. (herbal.guide)
- In this study, we examined the ex vivo urinary anti-adhesion activity of low-calorie cranberry extract beverages in both a pilot study (n = 10) and a randomized, double-blind, placebo controlled clinical trial (n = 59). (herbal.guide)
- Results from the pilot study indicated that ex vivo anti-adhesion activity for both cranberry treatments were higher (p (herbal.guide)
- Therefore, acute beverage consumption of cranberry extract and/or juice provides ex vivo anti-adhesion activity, which may help to improve urinary tract health. (herbal.guide)
- Cell surface carbohydrates in cell adhesion. (nih.gov)
- As originally described by Lancefield, beta-hemolytic streptococci can be divided into many groups based on the antigenic differences in group-specific polysaccharides located in the bacterial cell wall. (medscape.com)
- 0.05) adhesion to the GP202 cell line, when compared to the MKN45 cell line. (nih.gov)
- Bacterial meningitis in the United States, 1986: report of a multistate surveillance study. (cdc.gov)
- Antibodies to the N-region or V-region polypeptides, but not antibodies to the rC-Msp fragment, blocked adhesion of T. denticola ATCC 35405 cells to a range of host protein molecules. (nih.gov)
- There were no differences observed in anti-adhesion activity between CJEB and LCJC, indicating similar bioactivity. (herbal.guide)
- The three-dimensional folding gives rise to hollow channels that rapidly increase the effective volume occupied by the biofilm and facilitate bacterial movement inside them. (elifesciences.org)
- These results suggest that the N-terminal half of Msp carries epitopes that are surface exposed and that are involved in mediating adhesion. (nih.gov)
- Bacterial properties were determined using the microbial adhesion to solvents (MATS) assay, and bacterial surface free energy (SFE) was measured spectrophotometrically. (nih.gov)
- The results indicated that the degree of crystallinity (78.6% vs. 34.2%, with average crystallite size 50.54 nm vs. 32.86 nm) is the principal feature promoting the adhesion strength, through lower nanoscale roughness and possibly higher surface stiffness. (nih.gov)
- We see that pilin subunits must rotate to form a helical filament, after exiting linearly from the bacterial surface. (bu.edu)
- To evaluate the influence of MUC1 mucin variable number of tandem repeats (VNTR) variability on H pylori adhesion to gastric cells. (nih.gov)
- Specific immune response in the respiratory tract after administration of an oral polyvalent bacterial vaccine. (who.int)
- In this study, we analyzed the early stages of bacterial adhesion on two commercial dense polytetrafluoroethylene (d-PTFE) membranes in order to identify microstructural features that led to different adhesion strengths. (nih.gov)
- A ubiquitous organism, S pyogenes is the most common bacterial cause of acute pharyngitis , accounting for 15-30% of cases in children and 5-10% of cases in adults. (medscape.com)
- Handbook of bacterial adhesion : : principles, methods, and applications / edited by Yuehuei H. An and Richard J. Friedman. (who.int)